Sample records for iraldo michela melis

  1. Geology of volcanogenic massive sulfide deposit near Meli ...

    African Journals Online (AJOL)

    VMS) deposit near Meli/Rahwa, northern Ethiopia are presented in the paper. The study area forms part of Neoproterozoic basement of northern Ethiopia and southern part of the Arabian Nubian Shield (ANS). Selected surface rock samples of ...

  2. Preliminary approach of the MELiSSA loop energy balance (United States)

    Poulet, Lucie; Lamaze, Brigitte; Lebrun, Jean

    Long duration missions, such as the establishment of permanent bases on the lunar surface or the travel to Mars, require a huge amount of life support consumables (e.g. food, water and oxygen). Current rockets are at the moment unable to launch such a mass from Earth. Consequently Regenerative Life Support Systems are necessary to sustain long-term manned space mission to increase recycling rates and so reduce the launched mass. Thus the European and Canadian research has been concentrating on the MELiSSA (Micro-Ecological Life Support System Alternative) project over the last 20 years. MELiSSA is an Environmental Controlled Life Support System (ECLSS), i.e. a closed regenerative loop inspired of a lake ecosystem. Using light as a source of energy, MELiSSA's goal is the recovery of food, water and oxygen from CO2 and organic wastes, using microorganisms and higher plants. The architecture of a ECLSS depends widely on the mission scenario. To compare several ECLSS architectures and in order to be able to evaluate them, ESA is developing a multi criteria evaluation tool: ALISSE (Advanced LIfe Support System Evaluator). One of these criteria is the energy needed to operate the ECLSS. Unlike other criteria like the physical mass, the energy criterion has not been investigated yet and needs hence a detailed analysis. It will consequently be the focus of this study. The main objective of the work presented here is to develop a dynamic tool able to estimate the energy balance for several configurations of the MELiSSA loop. The first step consists in establishing the energy balance using concrete figures from the MELiSSA Pilot Plant (MPP). This facility located at the Universitat Autonoma de Barcelona (UAB) is aimed at the ground demonstration of the MELiSSA loop. The MELiSSA loop is structured on several subsystems; each of them is characterized by supplies, exhausts and process reactions. For the purpose of this study (i.e. a generic tool) the solver EES (Engineering

  3. Preliminary study of the space adaptation of the MELiSSA life support system (United States)

    Mas-Albaigès, Joan L.; Duatis, Jordi; Podhajsky, Sandra; Guirado, Víctor; Poughon, Laurent

    MELiSSA (Micro-Ecological Life Support System Alternative) is an European Space Agency (ESA) project focused on the development of a closed regenerative life support system to aid the development of technologies for future life support systems for long term manned planetary missions, e.g. a lunar base or missions to Mars. In order to understand the potential evolution of the MELiSSA concept towards its future use in the referred manned planetary mission context the MELiSSA Space Adaptation (MSA) activity has been undertaken. MSA's main objective is to model the different MELiSSA compartments using EcosimPro R , a specialized simulation tool for life support applications, in order to define a preliminary MELiSSA implementation for service in a man-tended lunar base scenario, with a four-member crew rotating in six-month increments, and performing the basic LSS functions of air revitalization, food production, and waste and water recycling. The MELiSSA EcosimPro R Model features a dedicated library for the different MELiSSA elements (bioreactors, greenhouse, crew, interconnecting elements, etc.). It is used to dimension the MELiSSA system in terms of major parameters like mass, volume and energy needs, evaluate the accuracy of the results and define the strategy for a progressive loop closure from the initial required performance (approx.100 The MELiSSA configuration(s) obtained through the EcosimPro R simulation are further analysed using the Advanced Life Support System Evaluation (ALISSE) metric, relying on mass, energy, efficiency, human risk, system reliability and crew time, for trade-off and optimization of results. The outcome of the MSA activity is, thus, a potential Life Support System architecture description, based on combined MELiSSA and other physico-chemical technologies, defining its expected performance, associated operational conditions and logistic needs.

  4. MELiSSA Food Characterization general approach and current status (United States)

    Weihreter, Martin; Chaerle, Laury; Secco, Benjamin; Molders, Katrien; van der Straeten, Dominique; Duliere, Eric; Pieters, Serge; Maclean, Heather; Dochain, Denis; Quinet, Muriel; Lutts, Stanley; Graham, Thomas; Stasiak, Michael; Rondeau Vuk, Theresa; Zheng, Youbin; Dixon, Mike; Laniau, Martine; Larreture, Alain; Timsit, Michel; Aronne, Giovanna; Barbieri, Giancarlo; Buonomo, Roberta; Veronica; Paradiso, Roberta; de Pascale, Stafania; Galbiati, Massimo; Troia, A. R.; Nobili, Matteo; Bucchieri, Lorenzo; Page, Valérie; Feller, Urs; Lasseur, Christophe

    Higher plants play an important role in closed ecological life support systems as oxygen pro-ducers, carbon dioxide and water recyclers, and as a food source. For an integration of higher plant chambers into the MELiSSA (Micro Ecological Life Support System Alternative) loop, a detailed characterization and optimization of the full food production and preparation chain is needed. This implies the prediction and control of the nutritional quality of the final products consumed by the crew, the prediction of the wastes quality and quantity produced along the chain for further waste treatment (MELiSSA waste treatment) and the optimization of overall efficiencies. To reach this goal several issues have to be studied in an integrated manner: the physiological responses of crops to a range of environmental parameters, crop yield efficiencies and respective ratio and composition of edible and inedible biomass, the processability and storability of the produced food and last but not least composition of wastes in view of further degradation (fiber content). Within the Food Characterization (FC) project several compar-ative plant growth bench tests were carried out to obtain preliminary data regarding these aspects. Four pre-selected cultivars of each of the four energy-rich crops with worldwide usage -wheat, durum wheat, potato and soybean -were grown under well-characterized environmental conditions. The different cultivars of each species are screened for their performance in view of a closed loop application by parameter ranking. This comprises the characterization of edi-ble/inedible biomass ratio, nutritional quality, processability and overall performance under the specific conditions of hydroponic cultivation and artificial illumination. A second closely linked goal of the FC project is to develop a mechanistic physiological plant model, which will ease the integration of higher plants compartments in the MELiSSA concept by virtue of its predictive abilities

  5. MELiSSA celebrates 25 years of research into life support

    International Nuclear Information System (INIS)


    MELiSSA (Micro-Ecological Life Support System Alternative) is a collaborative project with the European Space Agency ESA and various other scientific partners. The objective of MELiSSA is to develop a system that is able to provide manned space missions with food, drinking water and oxygen autonomously in space. Drinkable water and oxygen are currently being made in the international space station ISS by filtering waste water and by electrolysing water. However, such physiochemical technologies do not offer a solution for food. The MELiSSA project intends to reuse waste products, which include CO2, water, stools and urine from the astronauts, and even the perspiration moisture in the cabin and to transfer these into food through the use of micro-organisms.

  6. Cystobasidiomycetes yeasts from Patagonia (Argentina): description of Rhodotorula meli sp. nov. from glacial meltwater. (United States)

    Libkind, Diego; Sampaio, José Paulo; van Broock, Maria


    A basidiomycetous yeast, strain CRUB 1032(T), which formed salmon-pink colonies, was isolated from glacial meltwater in Patagonia, Argentina. Morphological, physiological and biochemical characterization indicated that this strain belonged to the genus Rhodotorula. Molecular taxonomic analysis based on the 26S rDNA D1/D2 domain and internal transcribed spacer region sequences showed that strain CRUB 1032(T) represents an undescribed yeast species, for which the name Rhodotorula meli sp. nov. is proposed (type strain is CRUB 1032(T)=CBS 10797(T)=JCM 15319(T)). Phylogenetic analysis showed that Rhodotorula lamellibrachii was the closest known species, which, together with R. meli, formed a separate cluster related to the Sakaguchia clade within the Cystobasidiomycetes. Additional Patagonian yeast isolates of the class Cystobasidiomycetes are also investigated in the present work.

  7. Surviving space flight: case study on MELiSSA's CIII nitrifying compartment (United States)

    Ilgrande, Chiara; Lasseur, Christophe; Mastroleo, Felice; Paille, Christel; Leys, Natalie; Morozova, Julia; Ilyin, Vyacheslav; Clauwaert, Peter; Christiaens, Marlies E. R.; Lindeboom, Ralph E. F.; Vlaeminck, Siegfried; Prat, Delphine; Arroyo, Jose M. C.; Conincx, Ilse; Van Hoey, Olivier; Roume, Hugo; Udert, Kai; Sas, Benedikt


    Space synthetic biology offers key opportunities for long-term space missions. Planets mining, terraformation, space medicine and Life Support technologies would all benefit from an integrative biological approach. However, space is a harsh environment for life: microgravity, temperature, UV and cosmic radiation can affect the health and functionality of microorganisms and plants, possibly preventing the optimal performance of the systems. The European Space Agency's Life Support System (MELiSSA) has been developed as a model for future long term Space missions and Space habitation. MELiSSA is a 5 compartment artificial ecosystem with microorganisms and higher, that aims at completely recycling gas, liquid and solid waste. In this study, the survival and functional activity after Lower Earth Orbit conditions of microbial nitrogen conversions, relevant for MELiSSA's CIII compartment, was tested. Synthetic communities containing Nitrosomonas europeae, Nitrosomonas ureae, Nitrobacter winogradskyi, Nitrospira moscoviensis and Cupriavidus pinatubonensis were exposed to the Lower Earth Orbit conditions of the International Space Station (ISS) for 7 days. Nitrosomonas europeae, Nitrobacter winogradskyi, Cupriavidus pinatubonensis, and three mixed communities (a urine nitrification sludge, a sludge containing aerobic ammonia oxidizing bacteria and anammox bacteria (OLAND), and an aquaculture sludge containing ammonia oxidizing archaea) were exposed to Lower Earth Orbit conditions for 44 days. Survival after both space flights was demonstrated because nitritation, nitratation, denitrification and anammox activity could be restored at a rate comparable to ground storage conditions. Our results validate the potential survival feasibility and suggest future space applications for N-related microorganisms.

  8. Análisis y propuesta de mejora del Hotel Meliá en Alicante




    [ES] El proyecto, que a continuación se desarrolla, es un análisis estratégico y propuesta de mejora de un hotel. Con el fin de aplicar la teoría a una empresa concreta, se ha tomado como objeto de estudio, al Hotel Meliá Alicante, por ser un hotel legendario y de gran renombre en la zona de Alicante tanto por su arquitectura como por su alta categoría. En una primera aproximación al sector, se describe éste a través de sus principales características, las variables que condicionan su evoluci...

  9. MELiSSA third compartment: Nitrosomonas europaea and Nitrobacter winogradskyi axenic cultures in bioreactors (United States)

    Cruvellier, Nelly; Lasseur, Christophe; Poughon, Laurent; Creuly, Catherine; Dussap, Gilles

    Nitrogen is a key element for the life and its balance on Earth is regulated by the nitrogen cycle. This loop includes several steps among which nitrification that permits the transformation of the ammonium into nitrate. The MELiSSA loop is an artificial ecosystem designed for life support systems (LSS). It is based on the carbon and nitrogen cycles and the recycling of the non-edible part of the higher plants and the waste produced by the crew. In this order, all the wastes are collected in the first compartment to degrade them into organic acids and CO2. These compounds are joining the second compartment which is a photoheterotrophic compartment where at the outlet an organic-free medium containing ammonium is produced. This solution will be the substrate of the third compartment where nitrification is done. This compartment has to oxidize the ammonium into nitrate, and this biological reaction needs two steps. In the MELiSSA loop, the nitrification is carried out by two bacteria: Nitrosomonas europaea ATCC® 19718™ which is oxidizing ammonia into nitrite and Nitrobacter winogradskyi ATCC® 25391™ which is producing nitrate from nitrite in the third compartment. These two bacteria are growing in axenic conditions on a fixed bed bioreactor filled with Biostyr® beads. The nitrogen compounds are controlled by Ionic Chromatography and colorimetric titration for each sample. The work presented here deals with the culture of both bacteria in pure cultures and mixed cultures in stirred and aerated bioreactors of different volumes. The first aim of our work is the characterization of the bacteria growth in bioreactors and in the nitrifying fixed-bed column. The experimental results confirm that the growth is slow; the maximal growth rate in suspended cultures is 0.054h-1 for Nitrosomonas europaea and 0.022h-1 for Nitrobacter winogradskyi. Mixed cultures are difficult to control and operate but one could be done for more than 500 hours. The characterization of the

  10. The influence of quorum sensing in compartment II of the MELiSSA loop (United States)

    Condori, Sandra; Mastroleo, Felice; Wattiez, Ruddy; Leys, Natalie

    MELiSSA (Micro-Ecological Life Support System Alternative) has been conceived as a 5 compartments microorganisms and higher plants recycling system for long haul space flights. Rhodospirillum rubrum S1H colonizes compartment II. Previous work reported that continuous culture of the bacterium in a photobioreactor could lead to thick biofilm formation, leading to bioreactor arrest. Our aim is to investigate the unknown quorum sensing (QS) system of R. rubrum S1H, specifically under MELiSSA relevant culture conditions meaning light anaerobic (LAN) and using acetate as carbon source. In that purpose an autoinducer synthase gene (Rru_A3396) knockout mutant was constructed by allelic exchange generating strain M68. In addition phenotypic comparison between wild type (WT) and M68 was performed. Results of thin layer chromatography assay where Agrobacterium tumefaciens NT1 have been used as reporter strain showed that WT produces acyl-homoserine lactones (AHLs) from C4 to C12 acyl carbon chain length; however, in M68 no AHLs were detected confirming that gene Rru_A3396 (named rruI) encodes an autoinducer synthase. Interestingly under a low shear or static environment M68 showed cell aggregation similar as reported in a closely related bacterium Rhodobacter sphaeroides (cerI mutant). In contrast to WT, M68 did not form biofilm and exhibited a decreased motility and pigment content. M68 vs wild type transcriptomics results showed that 326 genes were statistically significant differentially expressed. Downregulation of genes related to photosynthesis e.g., reaction center subunits, light harvesting complex and photosynthetic assembly proteins was observed. Similar results were obtained for preliminary proteomic analysis. Results obtained showed that in R. rubrum S1H the AHL-based QS system regulates almost 8% of the genome which is linked to biofilm formation among other biological processes described above. Since strain M68 could not be used in compartment II due to its less

  11. Production characteristics of lettuce Lactuca sativa L. in the frame of the first crop tests in the Higher Plant Chamber integrated into the MELiSSA Pilot Plant (United States)

    Tikhomirova, Natalia; Lawson, Jamie; Stasiak, Michael; Dixon, Mike; Paille, Christel; Peiro, Enrique; Fossen, Arnaud; Godia, Francesc

    Micro-Ecological Life Support System Alternative (MELiSSA) is an artificial closed ecosystem that is considered a tool for the development of a bioregenerative life support system for manned space missions. One of the five compartments of MELiSSA loop -Higher Plant Chamber was recently integrated into the MELiSSA Pilot Plant facility at Universitat Aut`noma deo Barcelona. The main contributions expected by integration of this photosynthetic compartment are oxygen, water, vegetable food production and CO2 consumption. Production characteristics of Lactuca sativa L., as a MELiSSA candidate crop, were investigated in this work in the first crop experiments in the MELiSSA Pilot Plant facility. The plants were grown in batch culture and totaled 100 plants with a growing area 5 m long and 1 m wide in a sealed controlled environment. Several replicates of the experiments were carried out with varying duration. It was shown that after 46 days of lettuce cultivation dry edible biomass averaged 27, 2 g per plant. However accumulation of oxygen in the chamber, which required purging of the chamber, and decrease in the food value of the plants was observed. Reducing the duration of the tests allowed uninterrupted test without opening the system and also allowed estimation of the crop's carbon balance. Results of productivity, tissue composition, nutrient uptake and canopy photosynthesis of lettuce regardless of test duration are discussed in the paper.

  12. Preliminary Modelling of Mass Flux at the Surface of Plant Leaves within the MELiSSA Higher Plant Compartments (United States)

    Holmberg, Madeleine; Paille, Christel; Lasseur, Christophe

    The ESA project Micro Ecological Life Support System Alternative (MELiSSA) is an ecosystem of micro-organisms and higher plants, constructed with the objective of being operated as a tool to understand artificial ecosystems to be used for a long-term or permanent manned planetary base (e.g. Moon or Mars). The purpose of such a system is to provide for generation of food, water recycling, atmospheric regeneration and waste management within defined standards of quality and reliability. As MELiSSA consists of individual compartments which are connected to each other, the robustness of the system is fully dependent on the control of each compartment, as well as the flow management between them. Quality of consumables and reliability of the ecosystem rely on the knowledge, understanding and control of each of the components. This includes the full understanding of all processes related to the higher plants. To progress in that direction, this paper focuses on the mechanical processes driving the gas and liquid exchanges between the plant leaf and its environment. The process responsible for the mass transfer on the surface of plant leaves is diffusion. The diffusion flux is dependent on the behaviour of the stoma of the leaf and also on the leaf boundary layer (BL). In this paper, the physiology of the leaf is briefly examined in order to relate parameters such as light quality, light quantity, CO2 concentration, temperature, leaf water potential, humidity, vapour pressure deficit (VPD) gradients and pollutants to the opening or closing of stomata. The diffusion process is described theoretically and the description is compared to empirical approaches. The variables of the BL are examined and the effect airflow in the compartment has on the BL is investigated. Also presented is the impact changes in different environmental parameters may have on the fluid exchanges. Finally, some tests, to evaluate the accuracy of the concluded model, are suggested.

  13. Effects of the Extraterrestrial Environment on Plants: Recommendations for Future Space Experiments for the MELiSSA Higher Plant Compartment

    Directory of Open Access Journals (Sweden)

    Silje A. Wolff


    Full Text Available Due to logistical challenges, long-term human space exploration missions require a life support system capable of regenerating all the essentials for survival. Higher plants can be utilized to provide a continuous supply of fresh food, atmosphere revitalization, and clean water for humans. Plants can adapt to extreme environments on Earth, and model plants have been shown to grow and develop through a full life cycle in microgravity. However, more knowledge about the long term effects of the extraterrestrial environment on plant growth and development is necessary. The European Space Agency (ESA has developed the Micro-Ecological Life Support System Alternative (MELiSSA program to develop a closed regenerative life support system, based on micro-organisms and higher plant processes, with continuous recycling of resources. In this context, a literature review to analyze the impact of the space environments on higher plants, with focus on gravity levels, magnetic fields and radiation, has been performed. This communication presents a roadmap giving directions for future scientific activities within space plant cultivation. The roadmap aims to identify the research activities required before higher plants can be included in regenerative life support systems in space.

  14. The MELiSSA GreenMOSS Study: Preliminary Design Considerations for a Greenhouse Module on the Lunar Surface (United States)

    Lobascio, Cesare; Paille, Christel; Lamantea, Matteo Maria; Boscheri, Giorgio; Rossetti, Vittorio

    Extended human presence on an extraterrestrial planetary surface will be made possible by the development of life support systems affordable in the long term. The key elements to support the goal will be the maximization of closure of air and water cycles, as well as the development of cost-effective and reliable hardware, including a careful strategic effort toward reduction of spare parts and consumables. Regenerative life support systems likely represent the final step toward long term sustainability of a space crew, allowing in situ food production and regeneration of organic waste. Referring to the MELiSSA loop, a key element for food production is the Higher Plant Compartment. The paper focuses on the preliminary design of a Greenhouse at the lunar South Pole, as performed within the “Greenhouse Module for Space System” (GreenMOSS) study, under a contract from the European Space Agency. The greenhouse is in support to a relatively small crew for provision of an energetic food complement. Resources necessary for the greenhouse such as water, carbon dioxide and nitrogen are assumed available, as required. The relevant mass and energy balances for incoming resources should be part of future studies, and should help integrate this element with the interfacing MELISSA compartments. Net oxygen production and harvested crop biomass from the greenhouse system will be quantified. This work presents the results of the two major trade-offs performed as part of this study: artificial vs natural illumination and monocrop vs multicrop solutions. Comparisons among possible design solutions were driven by the ALiSSE metric as far as practicable within this preliminary stage, considering mass and power parameters. Finally, the paper presents the mission duration threshold for determining the convenience of the designed solution with respect to other resources provision strategies

  15. Ungaretti tradutor discreto e a analogia entre os poetas árcades Tomás Antônio Gonzaga e Giovanni Meli

    Directory of Open Access Journals (Sweden)

    Lucia Wataghin


    Full Text Available Será apresentada e discutida a interessante analogia, sugerida por Giuseppe Ungaretti, entre a poesia de T.A. Gonzaga e a poesia em dialeto siciliano de um outro árcade, Giovanni Meli, seu contemporâneo. Em seguida, a partir das traduções realizadas por G. Ungaretti (1946. G. Vegezzi-Ruscalla (1844, E. de Monglave e P. Chalas (1825 da lira Tu não verás, Marília..., de T.A. Gonzaga, serão comentados aspectos do poema e de sua recepção em épocas e países diferentes.

  16. Strategic implications of corporate social responsibility in hotel industry: A comparative research between NH Hotels and Meliá Hotels International

    Directory of Open Access Journals (Sweden)

    Marina Mattera


    Full Text Available The hospitality industry serves millions of people globally and is a multibillion-dollar industry with a significant growth expectation in the upcoming years. The Spanish tourism industry is one of the most developed sectors of the nation, being one of the main contributors to the country’s GDP. On a world wide scale, and specifically in the European context, there is a rising awareness for firms’ actions to be responsible towards the environment and the community in which they operate. Based on “triple bottom line” guidelines, companies’ mission in such a context is achieving competitive advantage by means of a business model considering three key aspects: people, profit, and planet. Considering the hospitality industry’s characteristics, it becomes essential to fulfill these new requirements to achieve sustainable competitive advantages. This exploratory study will outline which are the best practices of two main Spanish hotel corporations: NH Hotels and Meliá Hotels International. By pointing out actions undertaken by the most important firms of the sector, they can serve as an example and be replicated by other firms, thus increasing sustainability practices, improving understanding of triple bottom line, minimizing negative social as well as environmental footprint, and enhancing positive firms’ impacts in their operating contexts. DOI: 10.18870/hlrc.v2i4.85

  17. Valoración de métodos convencionales y no convencionales para el control del taladrador de las meliáceas en América


    Ruiz, Bayron Alexander; Tamayo, Juan Carlos; Martínez, Melida; Medina, Henry Hernán; Salcedo, Eduardo; Hernández, Efrén; Palacios, Carlos Alexis; Silva, José Antonio; González, Ricardo


    En el presente artículo de revisión se hace una recapitulación de investigaciones recientes que se han realizado con el propósito de disminuir el efecto negativo producido por los insectos Hypsipyla grandella e Hypsipyla robusta (taladrador de los brotes tiernos) en plántulas pertenecientes a la familia de las meliáceas, destacando la caoba (Swietenia macrophylla) y el cedro (Cedrela odorata), consideradas de suma importancia comercial por su estructura y calidad de la madera en la industria ...

  18. Efeito de extratos aquosos de meliáceas sobre Bemisia tabaci biótipo B em tomateiro Effect of aqueous extracts of meliaceous plants on Bemisia tabaci B biotype on tomato plants

    Directory of Open Access Journals (Sweden)



    Full Text Available Comparou-se a bioatividade de extratos aquosos a 3% (p/v de três meliáceas, Melia azedarach L. (frutos verdes, Trichilia pallida Swartz (ramos e Azadirachta indica A. Juss (sementes, em relação à mosca branca Bemisia tabaci (Gennadius biótipo B, criada em tomateiro. No primeiro experimento os extratos foram aplicados sobre ovos e sobre ninfas com três dias de idade, avaliando-se a mortalidade e a duração das fases de ovo e de ninfa. No segundo experimento os extratos foram aplicados apenas sobre as ninfas, avaliando-se a mortalidade nessa fase e a longevidade e fecundidade dos adultos. Em relação à fase de ovo, o extrato de T. pallida foi o que provocou maior mortalidade, seguindo-se os de A. indica e M. azedarach. A maior mortalidade ninfal foi constatada com o extrato de A. indica, seguindo-se os de T. pallida e M. azedarach. Nenhum dos extratos afetou a duração das fases de ovo e de ninfa, assim como a longevidade e fecundidade.The objective of this research was to compare the effect of aqueous extracts of fresh fruits of Melia azedarach L., twigs of Trichilia pallida Swartz and seeds of zadirachta indica A. Juss, on eggs and nymphs of silverleaf whitefly Bemisia tabaci (Gennadius B biotype reared on tomato plants. The extracts were tested at a concentration of 3%. In the first experiment, the extracts were applied on eggs and 3-day-old nymphs. Records were taken on mortality, duration of egg and nymphal stages. In the second experiment the extracts were applied on 3-day-old nymphs and records were taken on nymphal mortality, adult longevity and fecundity. The extracts of T. pallida were the most effective on eggs, followed by A. indica and M. azedarach. The extracts of A. indica were the most effective on nymphs followed by T. pallida and M. azedarach. In both experiments, the duration of egg and nymph stages, longevity and fecundity were not affected by the extracts.

  19. Organik Gübre Kullanımının Yaygınlaştırılmasında Biogaz Üniteli Süt ve Besi Üretim Çiftlikleri Vasıtası ile ile Sözleşmeli Çiftçilik Modelinin Uygulanabilirliği

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    Jülide ERKMEN


    Full Text Available Ülkemizde mevcut süt ve besi işletmelerinin hayvansal yem ve maliyet girdilerinde problem yaşamaları, hayvansal yem üreticisinin ise hasat ettiği ürünü çoğu zaman elden çıkaramaması ekonomisi tarım ve hayvancılığa dayalı bölgelerde önemli bir sorun olarak karşımıza çıkmaktadır. Bununla birlikte biyogaz üniteli süt ve besi üretim çiftliklerinin biyogaz ünitelerinden elde edilen organik gübrenin yakın çevredeki hayvan yemi üreten çiftçiye dağıtılması ve karşılığında üretilen hayvansal yemin alınması suretiylegerçekleştirilecek sözleşmeli çiftçilik modeli, hem organik gübrenin yaygınlaştırılmasında hem de çevresel kirliliğe sebep olan hayvansal atık probleminin ortadan kaldırılmasında güçlü bir rol oynayacaktır. Ayrıca mevcut süt ve besi işletmeleri ile hayvansal yem üreticileri entegre edilerek üretilecek gübre yakın çevrede kullanılacağından paketleme ve pazarlama giderlerini ve ürünlerin elde kalma ihtimalini ortadan kaldıracaktır. Sonuç itibariyle özellikle kırsal bölgelerde biyogaz ünitesinin kurulumu ile organik gübrenin kullanımı teşvik edilecek, yapılacak sözleşme ile yine bu bölgelerde kimyasal gübrenin kullanımı önlenmiş olunacaktır

  20. Geology of volcanogenic massive sulfide deposit near Meli ...

    African Journals Online (AJOL)


    9.96 wt%. Fe2O3, 9.34-9.7 wt% CaO, 8.88-15.72 wt% MgO, 0.69-2.18 wt% Na2O, 1.7-2.31 wt% K2O, 0.29-. 0.81 wt% TiO2, 0.13-0.24 wt% MnO and 0.13-0.64 wt% P2O5. Similarly, intermediate metavolcanic rocks show variation from 60.65- ...

  1. Geology of volcanogenic massive sulfide deposit near Meli ...

    African Journals Online (AJOL)


    rocks where hydrothermal solutions interaction is more intense (Fig 3). A brecciated, possibly the vent, observed in the field, is also highly altered showing chloritization and sericitization. These alterations are assumed to be the result of the reaction of Fe-Si-Ca -rich hydrothermal fluid and the host rocks, and is common in ...

  2. Krytyka nowoczesnych stosunków społecznych jako podstawa ponowoczesnej sztuki życia – egzystencjalny wymiar dzieła Michela Foucault [The Critique of Modern Social Relations as the Foundation of the Postmodern Art of Life – the Existential Dimension of the Work of Michel Foucault

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    Markus Lipowicz


    Full Text Available The aim of the present article is to reveal the essential connection of MichelFoucault’s critical attitude regarding social relationships with the formation of thepostmodern ethos of making out of the human life an artwork. It will be shown thatthe main object of Foucault’s critique are the relations of power and knowledge inthe Christian priesthood and their modern transformation in nonreligious institutions.From this point of view, mainly based on the philosophy of Friedrich Nietzsche,the Christian ethics occur to be an accumulation of techniques of disciplinizationand normalization. This attitude towards Christianity and modernity leads to thepostmodern ethos of making out of life an artwork. This notion is mainly based onthe antique Greek and Roman philosophy, where instead of obeying to universalethical principles the human being struggled to be his own master. Therefore thepostmodern existence tries to be beyond all traditional boundaries, which resultsin the danger of neglecting the historical fact, that Christianity was and still is animportant institution of the Western Civilization.

  3. MeB5O8(Me-Li, Na, K, NH4)-H2NCONHCOCH3-H2O system at 25 deg C

    International Nuclear Information System (INIS)

    Skvortsov, V.G.; Fedorov, Yu.A.; Molodkin, A.K.; Tsekhanskij, R.S.


    Using the methods of isothermal solubility, densi- and refractometry, systems MB 5 O 8 (M-Li, Na, K, NH 4 )-acetylcarbamide - H 2 O at 25 deg C have been studied. It is ascertained, that the systems investigated are of simple eutonic type

  4. Ab initio study of spectroscopic properties of bimetallic molecules MeB (where Me=Li, Na, K, Br, Cs, Fr) using CCSD(T) and MRCI methods

    International Nuclear Information System (INIS)

    Cukovicova, M.; Cernusak, I.


    For our study we have chosen a series of diatomic molecules MeB (where Me = Li, Na, K, Rb, Cs, Fr). These molecules present experimentally unknown species, hence we were motivated to predict theoretically potential energy curves, equilibrium bond lengths, harmonic frequencies, constants of anharmonicity, dipole moments and dissociation energies for the ground and low-lying excited states using high level ab initio techniques. Based on previous state averaged MRCI calculations in ANO-S basis set of NaB and KB molecules, we have focused on four lowest-lying electronic states, ground state 3Π and excited states 1Σ+, 1Π and 3Σ+. All four states dissociate to the atoms in ground states 2P1/2(B) and 2S1/2(Me). 3Π, 1Σ+, 1Π and 3Σ+ electronic states we investigated employing CCSD(T) method using relativistic ANO-RCC basis set. Our calculations include scalar relativistic effects via the second order one-component (spin-free) Douglas-Kroll-Hess Hamiltonian. Relativistic effects become remarkable in the case of heavy atoms, hence properties of CsB and FrB molecules may differ from trend of properties in row from LiB to FrB. Spectroscopic properties of particular state were obtained from the analysis of the potential energy curves using VIBROT and DUNHAM programs.

  5. Strategic Implications of Corporate Social Responsibility in Hotel Industry:  A Comparative Research between NH Hotels and Meliá Hotels


    Mattera, Marina; Moreno Melgarejo, Alberto


    The hospitality industry serves millions of people globally and is a multibillion-dollar industry with a significant growth expectation in the upcoming years. The Spanish tourism industry is one of the most developed sectors of the nation, being one of the main contributors to the country’s GDP. On a world wide scale, and specifically in the European context, there is a rising awareness for firms’ actions to be responsible towards the environment and the community in which they operate. Based...

  6. Strategic Implications of Corporate Social Responsibility in Hotel Industry: A Comparative Research between NH Hotels and Meliá Hotels International (United States)

    Mattera, Marina; Moreno-Melgarejo, Alberto


    The hospitality industry serves millions of people globally and is a multibillion-dollar industry with a significant growth expectation in the upcoming years. The Spanish tourism industry is one of the most developed sectors of the nation, being one of the main contributors to the country's GDP. On a world wide scale, and specifically in the…

  7. Diseño de una herramienta de medición del impacto de la Responsabilidad Social Corporativa en una compañía hotelera, aplicado al caso práctico de Meliá Hotels International.


    Pericás Franco, José


    La información relativa a la sostenibilidad ocupa de cada vez más un espacio importante en los informes anuales de las compañías hoteleras. El presente trabajo indaga en la relación entre la comunicación de la Responsabilidad Social Corporativa hacia los grupos de interés, la obtención y proceso de los datos contenidos en los informes de sostenibilidad, y las tecnologías que permiten la automatización de los indicadores de sostenibilidad en el ámbito hotelero. Con el fin de contextualizar los...

  8. MeB/sub 5/O/sub 8/(Me-Li, Na, K, NH/sub 4/)-H/sub 2/NCONHCOCH/sub 3/-H/sub 2/O system at 25 deg C

    Energy Technology Data Exchange (ETDEWEB)

    Skvortsov, V G; Fedorov, Yu A; Molodkin, A K; Tsekhanskij, R S


    Using the methods of isothermal solubility, densi- and refractometry, systems MB/sub 5/O/sub 8/ (M-Li, Na, K, NH/sub 4/)-acetylcarbamide - H/sub 2/O at 25 deg C have been studied. It is ascertained, that the systems investigated are of simple eutonic type.

  9. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 28; Issue 6. A skeletochronological study of growth, longevity, and age at sexual maturity in a population of Rana latastei (Amphibia, Anura). Fabio M Guarino Silvia Lunardi Michela Carlomagno Stefano Mazzotti. Articles Volume 28 Issue 6 December 2003 pp 775-782 ...

  10. Computer-Aided Design of Drugs on Emerging Hybrid High Performance Computers (United States)


    8.00 Obaidur Rahaman, Trilce P. Estrada, Douglas J. Doren, Michela Taufer, Charles L. Brooks, Roger S. Armen . Evaluation of Several Two-Step Scoring...Parallel and Distributed Processing Symposium (IPDPS), . 2011/04/18 00:00:00, . : , 08/15/2011 9.00 T. Estrada, R. Armen , M. Taufer. Automatic Selection

  11. Toxicogenomic Response of Rhodospirillum rubrum S1H to the Micropollutant Triclosan▿


    Pycke, Benny F. G.; Vanermen, Guido; Monsieurs, Pieter; De Wever, Heleen; Mergeay, Max; Verstraete, Willy; Leys, Natalie


    In the framework of the Micro-Ecological Life Support System Alternative (MELiSSA) project, a pilot study was performed to identify the effects of triclosan on the MELiSSA carbon-mineralizing microorganism Rhodospirillum rubrum S1H. Triclosan is a biocide that is commonly found in human excrement and is considered an emerging pollutant in wastewater and the environment. Chronic exposure to MELiSSA-relevant concentrations (≥25 μg liter−1) of triclosan resulted in a significant extension of the...

  12. Antioxidant benzophenones and xanthones from the root bark of ...

    African Journals Online (AJOL)

    Antioxidant benzophenones and xanthones from the root bark of Garcinia smeathmannii. Alain Meli Lannang, Justin Komguem, Fernande Ngounou Ngninzeko, Jean Gustave Tangmouo, David Lontsi, Asma Ajaz, Muhammad Iqbal Choudhary, Beiban Luc Sondengam, Atta -ur-Rahman ...

  13. Moc jako aspekt terapeutického vztahu v rámci gestalt přístupu


    Krčmářová, Barbora


    The diploma thesis is focused on a phenomenon of power in therapy relationship in way of Gestalt approach. It's based on a relationship concept between psychotherapist and client which is a fundamental factor in psychoteraphy change. The power is perceived in accordance with Michela Foucalt's theory as a natural and necessary relational phenomenon. In Gestalt approach intentions we pursue ways, in which the psychoterapist is aware his power, how he gets in touch and how he deals with it. Dipl...

  14. Development of a microbiological ammonium to nitrate recycling bioreactor for space capsules

    International Nuclear Information System (INIS)

    Pycke, B.


    Since 1988, the Expertise group of Molecular and Cellular Biology (MCB) is an important partner in the development of the Micro-Ecological Life Support System Alternative (MELiSSA). The MELiSSA was designed to allow a small crew to survive on an Antarctic, lunar or Mars outpost, and is a joint research project currently fostered by the European Space Agency, ESA. The MELiSSA functions through a series of five interconnected compartments, of which four are microbial bioreactors and was engineered to degrade organic waste, regenerate the outpost's atmosphere and water, and provide the crew with an additional vegetarian diet. The bioreactor of the third compartment provides the edible cyanobacteria and plants of the fourth compartment with nitrate instead of ammonium as a source of nitrogen. The two bacteria responsible for the biological transformation of ammonium to nitrate (nitrification) are Nitrosomonas europaea and Nitrobacter winogradskyi. Since all MELiSSA-reactors are to be relied on for a period of several years, reactor operation is to be studied exhaustively to allow optimal process- and reactor performance. Therefore, a pilot reactor for the third compartment was engineered and constructed at the Universitat Autonoma de Barcelona (UAB), where the pilot plant of the MELiSSA is installed. The reactor was able to perform nitrification with high efficiency for the entire trial period of nearly five years and was the subject of this study. Collaboration between the unit of MCB and researchers at Universitat Autonoma de Barcelona (UAB) allowed the development and validation of a mathematical model for the third compartment of the MELiSSA. A mathematical model will allow optimizing reactor operation and reactor performance even further. A Real-Time Quantitative Polymerase Chain Reaction (Q-PCR) was developed at MCB that allowed the quantitative assessment of the relative distribution of the two autotrophic nitrifying bacterial species along the reactor's packed

  15. Pengaruh Hardiness terhadap Employee Engagement pada PNS Kementerian Pekerjaan Umum




    131301101 Employee engagement merupakan keadaan positif yang muncul bersama terkait dengan pekerjaan yang berhubungan dengan kesejahteraan yang ditandai dengan vigour, dedication, dan absorption. Salah satu faktor untuk mempengaruhi employee engagement adalah kepribadian, hardiness. Hardiness terdiri dari commitment, control,dan challenge dinilai sebagai salah satu bentuk kepribadian yang baik saat menghadapi keadaan yang penuh tekanan atau sumber stres. Penelitian ini dilakukan untuk meli...

  16. Bulletin of the Chemical Society of Ethiopia - Vol 20, No 2 (2006)

    African Journals Online (AJOL)

    Antioxidant benzophenones and xanthones from the root bark of Garcinia smeathmannii · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Alain Meli Lannang, Justin Komguem, Fernande Ngounou Ngninzeko, Jean Gustave Tangmouo, David Lontsi, Asma Ajaz, ...

  17. Browse Title Index

    African Journals Online (AJOL)

    Items 901 - 917 of 917 ... ... of deficit-irrigated maize in a semi-arid region of Ethiopia. Abstract PDF. M Yenesew, K Tilahun. Vol 11, No 4 (2011), Young children feeding and Zinc levels of complementary foods in Western Cameroon, Abstract PDF. SMM Kana, JK Kikafunda, FC Meli, I Gouado, PHA Zollo, D Oberleas, E Tetanye.

  18. Machine Learning wins the Higgs Challenge

    CERN Multimedia

    Abha Eli Phoboo


    The winner of the four-month-long Higgs Machine Learning Challenge, launched on 12 May, is Gábor Melis from Hungary, followed closely by Tim Salimans from the Netherlands and Pierre Courtiol from France. The challenge explored the potential of advanced machine learning methods to improve the significance of the Higgs discovery.   Winners of the Higgs Machine Learning Challenge: Gábor Melis and Tim Salimans (top row), Tianqi Chen and Tong He (bottom row). Participants in the Higgs Machine Learning Challenge were tasked with developing an algorithm to improve the detection of Higgs boson signal events decaying into two tau particles in a sample of simulated ATLAS data* that contains few signal and a majority of non-Higgs boson “background” events. No knowledge of particle physics was required for the challenge but skills in machine learning - the training of computers to recognise patterns in data – were essential. The Challenge, hosted by Ka...

  19. Revision of J3Gen and Validity of the Attacks by Peinado et al.

    Directory of Open Access Journals (Sweden)

    Alberto Peinado


    Full Text Available This letter is the reply to: Remarks on Peinado et al.’s Analysis of J3Gen by J. Garcia-Alfaro, J. Herrera-Joancomartí and J. Melià-Seguí published in Sensors 2015, 15, 6217–6220. Peinado et al. cryptanalyzed the pseudorandom number generator proposed by Melià-Seguí et al., describing two possible attacks. Later, Garcia-Alfaro claimed that one of this attack did not hold in practice because the assumptions made by Peinado et al. were not correct. This letter reviews those remarks, showing that J3Gen is anyway flawed and that, without further information, the interpretation made by Peinado et al. seems to be correct.

  20. North Spain (Burgos wild mammals ectoparasites

    Directory of Open Access Journals (Sweden)

    Domínguez G.


    Full Text Available Twenty-seven species of arthropods were collected from 105 wild mammals, six wolves Canis lupus (Linnaeus, 1758 included. A total of 87 animals (82,8 % harboured some ectoparasites. Ticks were found in 60 % of the samples, fleas in 51.4 %, chewing-lice in 3.8 %, and others (Mesostigmata and hippoboscids in 3.8 %. Moreover, 42.5 % were single infestation and 57.5 % mixed. Some of the species were new records for a host in spanish country such as Trichodectes canis (De Géer, 1778, Ixodes trianguliceps (Birula, 1895, Ceralophyllus (Monopsyllus S. sciurorum (Schrank, 1803 and Paraceras melis melis (Walker, 1856 on several mammals. Two species were new records for Spain: Chaetopsylla matina (Jordan, 1925 and Archaeopsylla erinacei erinacei (Bouché, 1835.

  1. Use of oral contraceptives in the management of acne


    Melis, Gian; Paoletti,Anna Maria; ORRU' ,; MAROTTO ,; PILLONI,; PERSEU,; Lello,Stefano


    Gian Benedetto Melis, Marisa Orrù, Maria Francesca Marotto, Monica Pilloni, Mariagrazia Perseu, Stefano Lello, Anna Maria PaolettiClinica Ginecologica Ostetrica e di Fisiopatologia della Riproduzione Umana, Universita' di Cagliari, Azienda Ospedaliero Universitaria di Cagliari, Cagliari, ItalyAbstract: The pathogenesis of acne (the most common disorder involving the sebaceous gland) originates from increased sebum production by the sebaceous gland followed by colonization o...

  2. 76 FR 40772 - Additional Designation of Entities Pursuant to Executive Order 13382 (United States)



  3. Model Pembatasan Beban Pencemar Untuk Pengelolaan Kualitas Sungai Citarum


    harsono, eko


    Daerah tangkapan (DAS) Citarum hulu mempunyai luas sekitar 177.100 ha, meli-puti kota Bandung dan kabupaten Bandung yang terletak di danau tua. Sungai Ci-tarum selain kegunaannya sebagai buangan limbah pabrik dan penduduk disekitar sungai, juga berfungsi sebagai penggerak listrik dan perikanan (jarring apung) di waduk Saguling dihilinya. Oleh karena kompleksnya pemanfaatan sungai ini, maka diperlukan suatu pendekatan pengelolaan di DAS Citarum tersebut. Penelitian ini tujuannya adalah untuk m...

  4. Enantioselective synthesis of C{sub 9}-C{sub 1}3 fragment of erythromycin B; Sintesis enantioselectiva del fragmento C{sub 9}-C{sub 1}3 de la eritromicina B

    Energy Technology Data Exchange (ETDEWEB)

    Dominguez, E.; Carretero, J.C. [Departamento de Quimica Organica, Universidad Autonoma, Madrid (Spain)


    A stereo controlled synthesis of the enantiomerically pure C{sub 9}-C{sub 1}3 fragment of erythromycin B is described. The process takes place in 15 steps from (R)-phenylsulfonyl p-tolylsulfinyl methane and butyraldehyde (16% overall yield). The key steps, corresponding to the formation of the chiral centers, are based on the iterative synthesis of gamma-hydroxivinylsulfones and further syb-sterereoselective addition of MeLi to their protected derivatives. 8 refs.



    Awal Isgiyanto


    Penelitian ini bertujuan untuk menemukan informasi diagnostik dari kesalahan jawaban peserta pada Ujian Nasional (UN) Matematika. Informasi diagnostik yang ditemukan meli-puti atribut yang mendasari butir soal, ketidaktuntasan atribut, dan jenis kesalahan yang dilakukan oleh peserta. Penelitian ini merupakan diagnosis post-hoc, yang digambarkan sebagai pende-katan retrofitting. Analisis butir soal dan respons butir pada UN mata pelajaran matematika untuk menemukan informasi diag-nostik pada k...

  6. Micropollutants in closed life-support systems: the case of triclosan, a biocide excreted via urine (United States)

    Mastroleo, Felice; Pycke, Benny; Boon, Nico; de Wever, Heleen; Hendrickx, Larissa; Mastroleo, Felice; Wattiez, Ruddy; Mergeay, Max; Verstraete, Willy

    OBJECTIVES: The impact of triclosan on the growth and physiology of the bacterium Rhodospirillum rubrum was studied in the frame of the regenerative life-support system, Micro- Ecological Life Support System Alternative (MELiSSA). A wide range of compounds, such as steroid hormones, pharmaceuticals and personal care products, might enter the life support system via the excrements that are to be treated and recycled. Triclosan was chosen as the first compound to be tested because MELiSSA is a closed system, which is consequently particularly sensitive to compounds inhibiting the microbial metabolism. Because triclosan is increasingly used as an antimicrobial biocide in hygienic formulations (such as toothpaste, mouthwash, deodorants, etc.) and due to its chemical stability, it is considered an emerging pollutant in terrestrial ecosystems. METHODS: In a first phase, the triclosan concentration expected in the life-support system was estimated, the Minimal Inhibitory Concentration (MIC) was determined via plating, and the effect on growth kinetics was assessed by comparing growth parameters in the Gompertz model. In a second phase, the secondary effects of triclosan on cell physiology and gene expression were studied through flow-cytometry and microarray analyses, respectively. RESULTS: Based on the pharmacokinetic data from literature, the predicted concentration range is estimated to be 6-25µg/L triclosan in the Rhodospirillum rubrum compartment of the MELiSSA. The minimal inhibitory concentration of triclosan was determined to be 71 µg/L after 7 days of exposure on Sistrom medium. Upon exposure to 50-200µg/L triclosan, triclosan-resistant mutants of Rhodospirillum rubrum arose spontaneously at high frequency (3.1 ∗ 10 - 4). Analysis of the growth kinetics of the wild-type revealed that triclosan causes an important elongation of the lag-phase and a decrease in growth rate. At concentrations higher than 75mg/L(LD = 500mg/L), triclosan is bactericidal to wild

  7. Advanced anaerobic bioconversion of lignocellulosic waste for the melissa life support system (United States)

    Lissens, G.; Verstraete, W.; Albrecht, T.; Brunner, G.; Creuly, C.; Dussap, G.; Kube, J.; Maerkl, H.; Lasseur, C.

    The feasibility of nearly-complete conversion of lignocellulosic waste (70% food crops, 20% faecal matter and 10% green algae) into biogas was investigated in the context of the MELiSSA loop (Micro-Ecological Life Support System Alternative). The treatment comprised a series of processes, i.e. a mesophilic laboratory scale CSTR (continuously stirred tank reactor), an upflow biofilm reactor, a fiber liquefaction reactor employing the rumen bacterium Fibrobacter succinogenes and a hydrothermolysis system in near-critical water. By the one-stage CSTR, a biogas yield of 75% with a specific biogas production of 0.37 l biogas g-1 VSS (volatile suspended solids) added at a RT (hydraulic retention time) of 20-25 d was obtained. Biogas yields could not be increased considerably at higher RT, indicating the depletion of readily available substrate after 25 d. The solids present in the CSTR-effluent were subsequently treated in two ways. Hydrothermal treatment (T ˜ 310-350C, p ˜ 240 bar) resulted in effective carbon liquefaction (50-60% without and 83% with carbon dioxide saturation) and complete sanitation of the residue. Application of the cellulolytic Fibrobacter succinogenes converted remaining cellulose contained in the CSTR-effluent into acetate and propionate mainly. Subsequent anaerobic digestion of the hydrothermolysis and the Fibrobacter hydrolysates allowed conversion of 48-60% and 30%, respectively. Thus, the total process yielded biogas corresponding with conversions up to 90% of the original organic matter. It appears that particularly mesophilic digestion in conjunction with hydrothermolysis offers interesting features for (nearly) the MELiSSA system. The described additional technologies show that complete and hygienic carbon and energy recovery from human waste within MELiSSA is technically feasible, provided that the extra energy needed for the thermal treatment is guaranteed.

  8. Estrategia de manejo de plagas en el cultivo del filodendro (PHILODENDRON scandens).


    Odalis Corbea Suárez; Moisés Figueroa Hernández; Manuel Pérez Quintana


    Se evaluaron Estrategias de  Manejo de plagas que contribuyeron a la recuperación de la estética del Philodendron  scandens    en el Hotel Meliá Varadero. Se estimuló y protegió la presencia de biorreguladores  con  la reducción de la carga tóxica. Durante los años 2001 al 2004 se realizaron estudios de las características del ecosistema tales como la interacción de los factores bió...

  9. Preclinical Testing of Novel Oxytocin Receptor Activators in Models of Autism Phenotypes (United States)


    higher incidence of autism observed in male versus female children . BALB/cByJ Cohort 1 (n ¼ 6 per treatment group; 6e7 weeks of age) was tested for acute...Veenstra-Vanderweele, J., 2011. A systematic review of medical treatments for children with autism spectrum disorders. Pediatrics 127, e1312ee1321. Melis...R.L., Leserman, J., Jarskog, L.F., Penn, D.L., 2011. Intranasal oxytocin reduces psychotic symptoms and improves theory of mind and social perception

  10. Prototipo de dispositivo de medida de rendimiento en running basado en acelerómetro triaxial y comunicación a dispositivo móvil




    [ES] Debido al creciente número de practicantes del deporte conocido de forma vulgar como ‘running’, se ha abierto un gran mercado para las aplicaciones y dispositivos relacionados con la monitorización de esta actividad. La aplicación desarrollada mediante Android, establecerá comunicación con los sensores alojados en el ‘CC2541 SensorTag’ para estudiar su viabilidad como posible puente para la fabricación de posteriores sistemas de medida de rendimiento. Melià De La Asunci...

  11. Satisfacción laboral y síndrome de Burnout en enfermeras del Servicio de Emergencia y Cuidados Críticos del Hospital San Bartolomé: 2010


    Broncano Vargas, Yrma Nilda


    Objetivo: Establecer la relación entre la satisfacción laboral y la prevalencia de Síndrome de Burnout en enfermeras del Hospital San Bartolomé. Material y Métodos: Enfoque cuantitativo, descriptivo, prospectivo, transversal y correlacional. La muestra estuvo constituida por 45 enfermeras de los servicios de Emergencia y Cuidados críticos en el mes de agosto 2010. Se utilizó la ficha de datos sociolaborales, el cuestionario de satisfacción laboral S21/26 de J.L. Meliá y cuestionario para la e...

  12. A Comparative Reference Study for the Validation of HLA-Matching Algorithms in the Search for Allogeneic Hematopoietic Stem Cell Donors and Cord Blood Units (United States)


    donors and cord blood units W. Bochtler1, L. Gragert2, Z. I. Patel3, J. Robinson3,4, D. Steiner5, J. A. Hofmann6, J. Pingel6, A. Baouz7, A. Melis8, J...cord blood units for individual patients is of primary importance. This challenging search process is routinely performed in a donor registry or cord...term ‘ donor ’ to refer to donors of HSCs from bone marrow or peripheral blood and cord blood units and the term ‘ donor registry’ shall include cord blood


    Directory of Open Access Journals (Sweden)

    Oscar Parada-Pérez


    Full Text Available The company hotel Cuban faces the challenge of the competitiveness and the client’s satisfaction in an environment that demands of actions that they assure the quality. This article has as objective to show the application of a procedure for the evaluation of the standards of quality of the offer in the restaurant buffet La Casona of the Hotel Meliá Santiago de Cuba. The results achieved by the application of the procedure allow to perfect the process of taking of decisions and it contributes to the efficiency of the hotel and the elevation of the quality of the service. 

  14. Co-rumination, anxiety, and maladaptive cognitive schemas: when friendship can hurt

    Directory of Open Access Journals (Sweden)

    Carlucci L


    Full Text Available Leonardo Carlucci, Ines D’Ambrosio, Marco Innamorati, Aristide Saggino, Michela Balsamo Department of Psychological Sciences, Health and Territory, “G. d’Annunzio” University, Chieti, Italy Background: This study investigated maladaptive cognitive schemas as mediators of the relationship between co-rumination and anxiety. Methods: Self-report measures of co-rumination, trait cognitive and somatic anxiety, and early maladaptive cognitive schemas were provided to a nonclinical sample of 461 young adults. Mediation of co-rumination and trait somatic and cognitive anxiety by each early maladaptive schema domain was tested using nonparametric, bootstrap-based resampling. Results: Significant associations between co-rumination and trait and cognitive anxiety were mediated by schema domains related to Rejection and Disconnection, Overvigilance and Inhibition, and Impaired Autonomy. The association between co-rumination and somatic anxiety was mediated by domains related to Rejection and Disconnection and Impaired Autonomy. Conclusion: The results of this study showed that those who engage in co-rumination, potentially resulting in clinical levels of anxiety, might benefit from treatment that focuses on themes of rejection sensitivity and belonging, beliefs about autonomy, and when the anxiety is more cognitive, treatment that focuses on hypercriticalness and emotional inhibition too. Keywords: anxiety, communication, domain, mediation, adults

  15. Université de Genève

    CERN Multimedia


    Ecole de physique - Département de physique nucléaire et corspusculaire 24, quai Ernest-Ansermet 1211 GENÈVE 4 Tél: (022) 379 62 73 - Fax: (022) 379 69 92 Wednesday 17 décembre 2008 PARTICLE PHYSICS SEMINAR at 17.00 hrs – Stückelberg Auditorium Bent crystals: a long story and its new frontiers by Dr Michela Prest / Universita degli Studi dell’Insubria, sede di Como When a particle physicist hears the world "crystal", he usually thinks of calorimeters, silicon detectors, a state of matter. When he hears the word "magnet", he thinks of bulky, heavy objects. In 1976, E. H. Tsyganov experimentally demonstrated how a bent crystal 1 mm thick, a couple of mm wide and a few cm high can steer particles as a dipole of several tens of Tesla. Crystals and the channelling phenomena have been studied for around 30 years. Hadron beam collimation has been immediately identified as their main application and the understanding of the physics of crystals and their experimental stu...

  16. La Contabilità pratica prima di Luca Pacioli: Origine della Partita Doppia

    Directory of Open Access Journals (Sweden)

    Carlo Antinori


    El trabajo prosigue con un estudio comparativo de las prácticas contables previas a la publicación del Tractatus XI de Luca Pacioli, contenido en su Summa de Arithmetica, seguidas en las principales regiones italianas: Venecia y sus territorios, Milán y la Lombardía, Génova y la Liguria, la Emilia-Romaña y la Toscana. Se describen las particularidades de los distintos tipos de contabilidad surgidos en cada una de estas regiones, señalando las similitudes y diferencias entre cada uno de ellos, así como sus respectivas aproximaciones a la partida doble. El artículo se detiene especialmente en la asignación que Federico Melis hace en exclusiva a la Toscana como descubridora de la contabilidad por partida doble. A estos efectos, estudia las características que Luca Pacioli atribuye a este método contable, por considerar que las mismas constituyen el paradigma de la partida doble. Luego se pasa revista a las diferencias existentes entre el modelo pacioliano y el propuesto por Federico Melis, diferencias que se considera son debidas a un excesivo provincianismo de este autor, empeñado en atribuir a la Toscana la paternidad de la contabilidad por partida doble, cuando en realidad parece que este método fue desarrollado casi simultáneamente en diversas regiones italianas.

  17. Insight into the radiotolerance of the life support bacterium Rhodospirillum rubrum S1H by means of phenotypic and transcriptomic methods (United States)

    Mastroleo, Felice; Monsieurs, Pieter; Leys, Natalie

    The MELiSSA life support system from the European Space Agency is targeting the produc-tion of oxygen, water and food by recycling organic waste. Among different types of pro-cesses, MELiSSA uses several interconnected bioreactors inhabited by microorganisms and higher plants (Hendrickx et al., 2006; Mergeay et al., 1988). Because this loop is foreseen to be functional in space where it will be exposed to higher doses and different spectra of ionizing radiation, it was decided to screen the radiotolerance of the organisms used. In this study, the radiotolerance (i.e. tolerance to ionizing radiation) of the photosynthetic bacterium Rho-dospirillum rubrum S1H was investigated. In this test, first the effect of low energy Cobalt-60 gamma rays, were tested. To assess the radiotolerance of bacterium S1H, the survival rate after increasing exposure was determined. R. rubrum S1H appeared relatively radiosensitive, as the radiation dose at which 90% of the population was killed (D10 value) was 4 times lower than the model bacterium Escherichia coli. It was demonstrate that the culture medium has an impact on radiation tolerance. This survival curve also permitted to select a number of sub-lethal ionizing radiation doses (¡ D10 ), that were used to analyze the gene expression response of R. rubrum S1H after gamma irradiation. The microarray transcriptome analysis results ob-tained from different doses and different culture medium showed a significant response of the bacterium to sublethal doses. Potential marker genes for ionizing radiation stress in R. rubrum S1H were identified. By quantitative PCR, it was shown that the expression of these marker genes increased with the recovery time after exposure to ionizing radiation. In other words, the radiation tolerance and the response of R. rubrum S1H to low energy Cobalt-60 gamma ionizing radiation was characterized. Therefore to ensure MELiSSA process robustness during extended space exploration mission, it is advised that

  18. Looking at the stability of life-support microorganisms in space : the MELGEN activity highlights the cyanobacterium Arthrospira sp. PCC8005 (United States)

    Morin, Nicolas

    The MELGEN activity (MELiSSA Genetic Stability Study) mainly covers the molecular aspects of the regenerative life-support system MELiSSA (Micro-Ecological Life Support System Alternative) of the European Space Agency (ESA). The general objective of MELGEN is to establish and validate methods and the related hardware in order to detect genetic instability and microbial contaminants in the MELISSA compartments. This includes (1) a genetic description of the MELISSA strains, (2) studies of microbial behavior and genetic stability in bioreactors and (3) the detection of chemical, genetical and biological contamination and their effect on microbial metabolism. Selected as oxygen producer and complementary food source, the cyanobacterium Arthrospira sp. PCC8005 plays a major role within the MELiSSA loop. As the genomic information on this organism was insufficient, sequencing of its genome was proposed at the French National Sequencing Center, Genoscope, as a joint effort between ESA and different laboratories. So far, a preliminary assembly of 16 contigs representing circa 6.3 million basepairs was obtained. Even though the finishing of the genome is on its way, automatic annotation of the contigs has already been performed on the MaGe annotation platform, and curation of the sequence is currently being carried out, with a special focus on biosynthesis pathways, photosynthesis, and maintenance processes of the cell. According to the index of repetitiveness described by Haubold and Wiehe (2006), we discovered that the genome of Arthrospira sp. is among the 50 most repeated bacterial genomes sequenced to date. Thanks to the sequencing project, we have identified and catalogued mobile genetics elements (MGEs) dispersed throughout the unique chromosome of this cyanobacterium. They represent a quite large proportion of the genome, as genes identified as putative transposases are indeed found in circa 5 Results : We currently have a first draft of the complete genome of

  19. Mutant strains of Spirulina (Arthrospira) platensis to increase the efficiency of micro-ecological life support systems (United States)

    Brown, Igor

    The European Micro-Ecological Life Support System Alternative (MELiSSA) is an advanced idea for organizing a bioregenerative system for long term space flights and extraterrestrial settlements (Hendrickx, De Wever et al., 2005). Despite the hostility of both lunar and Martian environments to unprotected life, it seems possible to cultivate photosynthetic bacteria using closed bioreactors illuminated and heated by solar energy. Such reactors might be employed in critical processes, e.g. air revitalization, foodcaloric and protein source, as well as an immunomodulators production. The MELiSSA team suggested cyanobacterium Spirulina as most appropriate agent to revitalize air and produce a simple "fast" food. This is right suggestion because Spirulina was recently shown to be an oxygenic organism with the highest level of O2 production per unit mass (Ananyev et al., 2005). Chemical composition of Spirulina includes proteins (55Aiming to make Spirulina cultivation in life support systems like MELiSSA more efficient, we selected Spirulina mutant strains with increased fraction of methionine in the biomass of this cyanobacterium and compared the effect of parental wild strain of Spirulina and its mutants on the tendency of such experimental illnesses as radiationinduced lesions and hemolythic anemia. Results: It was found that mutant strains 198B and 27G contain higher quantities of total protein, essential amino acids, c-phycocyanin, allophycocyanin and chlorophyll a than parental wild strain of S. platensis. The strain 198B is also characterized with increased content of carotenoids. Revealed biochemical peculiarities of mutant strains suggest that these strains can serve as an additional source of essential amino acids as well as phycobiliproteins and carotenoids for the astronauts. Feeding animals suffering from radiation-induced lesions, c-phycocyanin, extracted from strain 27G, led to a correction in deficient dehydrogenase activity and energy-rich phosphate levels

  20. Kamu Hastaneleri Birlikleri verimlilik değerlendirmesinde verimlilik karnesi uygulaması


    Uçkun, Nurullah; Şahin, Ümit


    663 sayılı Kanun Hükmünde Kararname ile organizasyon ve yönetim yapısı değişen Sağlık Bakanlığına bağlı hastanelerin yönetimi, Bakanlık düzeyinde yapılandırılan Türkiye Kamu Hastaneleri Kurumu (TKHK) ve bu Kuruma bağlı olarak görev yapacak il düzeyinde oluşan Genel Sekreterliklere bağlı olacak şekilde planlanmış ve Aralık 2012 itibarı ile fiili uygulamaya geçilmiştir.  TKHK bağlı Genel Sekreterlik ve Genel Sekreterliklere bağlı hastanelerin sözleşmeli olarak atanan yöneticilerinin performans ...

  1. Saul Fia

    Directory of Open Access Journals (Sweden)

    Gonçal Mayos


    Full Text Available Reseña de: Saul fia (El hijo de Saúl, Año 2015, Duración 107 min., País Hungría, Director László Nemes, Guión László Nemes, Clara Royer, Música László Melis, Fotografía Mátyás Erdély; Reparto: Géza Röhrig,  Levente Molnár,  Urs Rechn,  Sándor Zsótér,  Todd Charmont,  Björn Freiberg,  Uwe Lauer,  Attila Fritz,  Kamil Dobrowolski,  Christian Harting;  Productora Laokoon Filmgroup.

  2. A comparative study of helminths of raccoon dogs (Nyctereutes procynoides and red foxes (Vulpes vulpes sharing the same territory

    Directory of Open Access Journals (Sweden)

    Rolf Karl Schuster


    Full Text Available Objective: To compare the helminth fauna of raccoon dogs (Nyctereutes procynoides and red foxes (Vulpes vulpes originating from the Uckermark distict, a rural area in the northeastern part of Germany. Methods: Internal organs of 101 legally hunted raccoon dogs and 144 red foxes were examined for helminths by helminthological dissection. Results: In total, 18 helminth species were detected of which 14 were present in raccoon dogs and 17 were detected in red foxes. In both host species, Mesocestoides litteratus, Uncinaria stenocephala and Toxocara canis occurred in comparably high prevalences. Significant differences in prevalence were seen in Isthmiophora melis and Alaria alata that were more often diagnosed in raccoon dogs and Taenia polyacantha that was more frequent in red foxes. Echinococcus multilocularis was present in both hosts in low prevalence. Conclusions: Both canid hosts sharing the same territories have a similar helminth spectrum. Differences in prevalence and abundance can be explained with distinct.

  3. On the nature of Ni···Ni interaction in a model dimeric Ni complex. (United States)

    Kamiński, Radosław; Herbaczyńska, Beata; Srebro, Monika; Pietrzykowski, Antoni; Michalak, Artur; Jerzykiewicz, Lucjan B; Woźniak, Krzysztof


    A new dinuclear complex (NiC(5)H(4)SiMe(2)CHCH(2))(2) (2) was prepared by reacting nickelocene derivative [(C(5)H(4)SiMe(2)CH=CH(2))(2)Ni] (1) with methyllithium (MeLi). Good quality crystals were subjected to a high-resolution X-ray measurement. Subsequent multipole refinement yielded accurate description of electron density distribution. Detailed inspection of experimental electron density in Ni···Ni contact revealed that the nickel atoms are bonded and significant deformation of the metal valence shell is related to different populations of the d-orbitals. The existence of the Ni···Ni bond path explains the lack of unpaired electrons in the complex due to a possible exchange channel.

  4. Thermogravimetric method of estimation of uranyl cation state in melts of alkali metal chlorides and their mixtures

    International Nuclear Information System (INIS)

    Vorobej, M.P.; Desyatnik, V.N.


    The thermogravimetric method was used to study the chloridizing of uranium oxides in molten media. The study of the uranium oxide chloridizing served as a basis for evaluating comparatively, using the DTA method, the uranyl-cation state in a melt. Using the alkali metals as example, it was shown that the decomposition of the frozen uranium oxychlorides proceeds with the formation of intermediate chlorouranates. The final product of the thermolysis are uranates Me 2 U 2 O 7 (Me-Li, Na, K, Rb, Cs). The time and the conditions of the change of uranium oxides to the oxyanion [UO 2 Cl 4 ] 2- were determined as a function of the chloridizing agent. The method can be employed for evaluating uranyl-ions in molten media where they are used as electrolytes in the extraction of uranium dioxide

  5. Discovery of a sexual stage in Trichophyton onychocola, a presumed geophilic dermatophyte isolated from toenails of patients with a history of T. rubrum onychomycosis

    DEFF Research Database (Denmark)

    Hubka, Vit; Nissen, Christoffer V; Jensen, Rasmus Hare


    Trichophyton onychocola is a recently described geophilic dermatophyte that has been isolated from a toenail of Czech patient with a history of onychomycosis due to T. rubrum and clinical suspicion of relapse. In this study, we report a similar case from Denmark in an otherwise healthy 56-year......-old man. The patient had a history of great toenail infection caused by T. rubrum in 2004 and presented with suspected relapse in 2011 and 2013. Trichophyton onychocola was the only microbial agent isolated at the second visit in 2013 and the identification was confirmed by DNA sequencing. Direct...... and the two isolates were successfully mated. The mating experiments with related heterothallic species T. thuringiense and Arthroderma melis were negative. The sexual state showed all typical signs of arthroderma-morph and is described by using optical as well as scanning electron microscopy. The sexual...

  6. Optimal management of nail disease in patients with psoriasis

    Directory of Open Access Journals (Sweden)

    Piraccini BM


    Full Text Available Bianca Maria Piraccini, Michela Starace Division of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy Abstract: Psoriasis is a common skin disease, with nail involvement in approximately 80% of patients. Nail psoriasis is often associated with psoriatic arthropathy. Involvement of the nails does not always have relationship with the type, gravity, extension, or duration of skin psoriasis. Nail psoriasis can occur at any age and all parts of the nails and the surrounding structures can be affected. Two clinical patterns of nail manifestations have been seen due to psoriasis: nail matrix involvement or nail bed involvement. In the first case, irregular and deep pitting, red spots of the lunula, crumbling, and leukonychia are seen; in the second case, salmon patches, onycholysis with erythematous border, subungual hyperkeratosis, and splinter hemorrhages are observed. These clinical features are more visible in fingernails than in toenails, where nail abnormalities are not diagnostic and are usually clinically indistinguishable from other conditions, especially onychomycosis. Nail psoriasis causes, above all, psychosocial and aesthetic problems, but many patients often complain about functional damage. Diagnosis of nail psoriasis is clinical and histopathology is necessary only in selected cases. Nail psoriasis has an unpredictable course but, in most cases, the disease is chronic and complete remissions are uncommon. Sun exposure does not usually improve and may even worsen nail psoriasis. There are no curative treatments. Treatment of nail psoriasis includes different types of medications, from topical therapy to systemic therapy, according to the severity and extension of the disease. Moreover, we should not underestimate the use of biological agents and new therapy with lasers or iontophoresis. This review offers an investigation of the different treatment options for nail

  7. Odpowiedź na pytanie

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    Michel Foucault


    Full Text Available Prezentowany artykuł Michela Foucaulta został opublikowany w 1963 roku. Foucault rozwija w nim koncepcję archeologii wiedzy – metody analizy historycznych dyskursów, którą zaprezentuje w sześć lat później w książce o tym właśnie tytule. Artykuł powstał na kanwie pytania wybranego przez autora spośród zadanych mu przez redakcję „Esprit”, które dotyczyło możliwości pojęciowego opracowania przymusu systemu dyskursywnego przy jednoczesnym zaakcentowaniu nieciągłości w jego obrębie a tym samym możliwości twórczego działania w historii ducha. A także, czy tak sformułowana aporia zakładałaby z konieczności zgodę na przymus systemu lub afirmację siły zdolnej do przekształcenia go za pomocą zewnętrznej przemocy? Tekst jest wprawką do sformułowania dojrzałej teorii dyskursu, rodzajem autoanalizy, która pozwala Foucaultowi powiązać własną metodę historyczną z „progresywistyczną polityką” myśli i rozwiązać w ten sposób dylemat pełnej determinacji i wolnego sprawstwa obecny w rozważaniach wielu strukturalistów.

  8. Alexithymia, impulsiveness, and psychopathology in nonsuicidal self-injured adolescents

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    Gatta M


    Full Text Available Michela Gatta,1 Francesco Dal Santo,1 Alessio Rago,1 Andrea Spoto,2 Pier Antonio Battistella1 1Childhood Adolescence Family Unit, Ulss 16 – Padua University, 2Department of General Psychology, Padua University, Padova, Italy Introduction: Nonsuicidal self-injury (NSSI is a multifaceted phenomenon and a major health issue among adolescents. A better understanding of self-injury comorbidities is crucial to improve our ability to assess, treat, and prevent NSSI.Purpose: This study aimed at analyzing some of the psychobehavioral correlates of NSSI: psychological problems, alexithymia, impulsiveness, and sociorelational aspects.Patients and methods: This was a case–control study. The clinical sample (n=33 included adolescents attending our unit for NSSI and other issues; the controls (n=79 were high-school students. Data were collected using six questionnaires: Youth Self-Report, Barratt’s Impulsiveness Scale, Toronto Alexithymia Scale, Children’s Depression Inventory, Symptom Checklist-90-R, and Child Behavior Checklist.Results: Cases scored significantly higher in all questionnaires. Habitual self-injurers scored higher on impulsiveness and alexithymia. The gesture’s repetition seems relevant to the global clinical picture: habitual self-injurers appear more likely to seek help from the sociosanitary services. We found a difference between the self-injurers’ and their parents’ awareness of the disorder.Conclusion: Habitual self-injurers show signs of having difficulty with assessing the consequences of their actions (nonplanning impulsiveness and the inability to manage their feelings. Given the significantly higher scores found for cases than for controls on all the psychopathological scales, NSSI can be seen as a cross-category psychiatric disorder, supporting the Diagnostic and Statistical Manual of Mental Disorders decision to include it as a pathological entity in its own right. Keywords: NSSI, self-cutting, psychiatric

  9. Itinerari nella Weltliteratur: Norma e letteratura

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    a cura di Silvia Lafuente


    Full Text Available  This section consists of seven contributions from the 2012 Giornate di Studio, which have been taking place at the University of Florence since 2009: Silvia Lafuente, "Forme d’oralità costruiscono la modernità letteraria argentina nelle prime decadi del ‘900"; Arianna Fiore, "La junta luz di Juan Gelman: un oratorio contro il silenzio"; Carolina Argenta, "Oltre la Generazione del Sessanta: la poesia di Susana Thénon"; Salomé Vuelta García, "I proverbi nella traduzione italiana di La Familia de Pascual Duarte di Camilo José Cela; Andrea Carmelo Spadola, "Bilinguismo / Translinguismo nell’opera poetica di César Moro"; Coral García Rodríguez, "La formazione di una identità europea  attraverso il linguaggio: l’apolide Jorge Semprún, oppure lo spagnolo delle tre patrie"; Michela Graziani, "Trasformismi jazz nella cultura portoghese del ‘900".During the IV Giornata di Studio, the concepts of «norm» and «deviation» in literary language were discussed from a variety of standpoints: linguistic, literary, cultural, historical and social. The various lines of research chosen by the authors of the seven contributions to LEA highlight the potential of literary language in linguistic and intellectual experiences within cultural contexts. In the light of this perspective, the seven contributions offer a number of itineraries for the interpretation of modern literature from Argentina, Peru, Portugal and Spain. This section was edited by Silvia Lafuente. 

  10. Biocompatible nanocomposite for PET/MRI hybrid imaging

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    Locatelli E


    Full Text Available Erica Locatelli,1 Larraitz Gil,2 Liron Limor Israel,3 Lorena Passoni,4,5 Maria Naddaka,1 Andrea Pucci,1 Torsten Reese,6 Vanessa Gomez-Vallejo,2 Paolo Milani,5,7 Michela Matteoli,4,8 Jordi Llop,2 Jean Paul Lellouche,3 Mauro Comes Franchini11Department of Industrial Chemistry “Toso Montanari”. University of Bologna, Italy; 2Radiochemistry Department, Molecular Imaging Unit, CIC biomaGUNE, San Sebastián, Guipúzcoa, Spain; 3Department of Chemistry, Nanomaterials Research Centre, Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel; 4Department of Medical Biotechnology and Translational Medicine, University of Milano, Italy; 5Fondazione Filarete, Milano, Italy; 6Imaging Department, Molecular Imaging Unit, CIC biomaGUNE, San Sebastián, Guipúzcoa, Spain; 7CIMAINA and Department of Physics, University of Milano, Italy; 8Humanitas Clinical and Research Center, Rozzano, ItalyAbstract: A novel nanocarrier system was designed and developed with key components uniquely structured at the nanoscale for early cancer diagnosis and treatment. In order to perform magnetic resonance imaging, hydrophilic superparamagnetic maghemite nanoparticles (NPs were synthesized and coated with a lipophilic organic ligand. Next, they were entrapped into polymeric NPs made of biodegradable poly(lactic-co-glycolic acid linked to polyethylene glycol. In addition, resulting NPs have been conjugated on their surface with a 2,2'-(7-(4-((2-aminoethylamino-1-carboxy-4-oxobutyl-1,4,7-triazonane-1,4-diyldiacetic acid ligand for subsequent 68Ga incorporation. A cell-based cytotoxicity assay has been employed to verify the in vitro cell viability of human pancreatic cancer cells exposed to this nanosystem. Finally, in vivo positron emission tomography-computerized tomography biodistribution studies in healthy animals were performed.Keywords: maghemite nanoparticles, organic coating, polymeric nanoparticles, magnetic resonance imaging

  11. Impulsivity, gender, and the platelet serotonin transporter in healthy subjects

    Directory of Open Access Journals (Sweden)

    Donatella Marazziti


    Full Text Available Donatella Marazziti, Stefano Baroni, Irene Masala, Francesca Golia, Giorgio Consoli, Gabriele Massimetti, Michela Picchetti, Mario Catena Dell’Osso, Gino Giannaccini, Laura Betti, Antonio Lucacchini, Antonio CiapparelliDipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, ItalyAbstract: The present study explored the possible relationships between impulsivity, gender, and a peripheral serotonergic marker, the platelet serotonin (5-HT transporter (SERT, in a group of 32 healthy subjects. The impulsivity was measured by means of the Barratt Impulsivity Scale, version 11 (BIS-11, a widely used self-report questionnaire, and the platelet SERT was evaluated by means of the specific binding of 3H-paroxetine (3H-Par to platelet membranes, according to standardized protocols. The results showed that women had a higher BIS-11 total score than men, and also higher scores of two factors of the same scale: the motor impulsivity and the cognitive complexity. The analysis of the correlations revealed that the density of the SERT proteins, as measured by the maximum binding capacity (Bmax of 3H-Par, was significantly and positively related to the cognitive complexity factor, but only in men. Men showed also a significant and negative correlation with the dissociation constant, Kd, of (3H-Par binding, and the motor impulsivity factor. These findings suggest that women are generally more impulsive than men, but that the 5-HT system is more involved in the impulsivity of men than in that of women.Keywords: impulsivity, gender, serotonin transporter, Barratt Impulsivity Scale, platelets, 3H-paroxetine

  12. Tris(bis(trimethylsilyl)amido)uranium: Compounds with tri-, tetra-, and penta-valent uranium

    Energy Technology Data Exchange (ETDEWEB)

    Stewart, J.L.


    This trivalent uranium compound, serves as a precursor to new tri-, tetra-, and penta-valent uranium species. The geometry about the U atom is pyramidal. Lewis-base coordination compounds of U(N(SiMe/sub 3/)/sub 2/)/sub 3/ with a one-to-one- ratio of Lewis base to uranium were isolated with pyridine, 4-dimethylamino-pyridine, 2,6-Me/sub 2/-C/sub 6/H/sub 3/NC, and TPO. Two-to-one coordination compounds were obtained with t-butylnitrile and t-butylisocyanide. Compounds with more sterically demanding bases could not be isolated. The expected decrease in U-N(SiMe/sub 3/)/sub 2/ bond length with increase in oxidation state is not observed. Reaction of ClU(N(SiMe/sub 3/)/sub 2/)/sub 3/and Li(NH(p-tolyl)) yields the uranium (IV) dimer, U/sub 2/(N(SiMe/sub 3/)/sub 2/)/sub 4/( 2/. Reaction with 2,4,6-triemethylaniline produces a dimer. Analogous substitution products could not be obtained with aniline or p-toluidine. t-Bu/sub 3/CO/sup /minus//, t-Bu/sub 2/CHO/sup /minus//, and t-Bu/sub 3/SiO/sup /minus// are used to synthesize new tetravalent, mononuclear uranium compounds. Reaction of ClU(tritox)/sub 3/ with alkyllithium reagents leads to isolation of RU(tritox)/sub 3/. The reaction of U(ditox)/sub 4/ with MeLi affords the addition product U(ditox)/sub 4/(Me)Li, whose crystal structure is described. Preparation of uranium silox compounds is reported. 97 refs., 26 figs., 39 tabs.

  13. Tris[bis(trimethylsilyl)amido]uranium: Compounds with tri-, tetra-, and penta-valent uranium

    International Nuclear Information System (INIS)

    Stewart, J.L.


    This trivalent uranium compound, serves as a precursor to new tri-, tetra-, and penta-valent uranium species. The geometry about the U atom is pyramidal. Lewis-base coordination compounds of U[N(SiMe 3 ) 2 ] 3 with a one-to-one- ratio of Lewis base to uranium were isolated with pyridine, 4-dimethylamino-pyridine, 2,6-Me 2 -C 6 H 3 NC, and TPO. Two-to-one coordination compounds were obtained with t-butylnitrile and t-butylisocyanide. Compounds with more sterically demanding bases could not be isolated. The expected decrease in U-N(SiMe 3 ) 2 bond length with increase in oxidation state is not observed. Reaction of ClU[N(SiMe 3 ) 2 ] 3 and Li[NH(p-tolyl)] yields the uranium (IV) dimer, U 2 [N(SiMe 3 ) 2 ] 4 [μ-N(p-tolyl)] 2 . Reaction with 2,4,6-triemethylaniline produces a dimer. Analogous substitution products could not be obtained with aniline or p-toluidine. t-Bu 3 CO/sup /minus//, t-Bu 2 CHO/sup /minus//, and t-Bu 3 SiO/sup /minus// are used to synthesize new tetravalent, mononuclear uranium compounds. Reaction of ClU(tritox) 3 with alkyllithium reagents leads to isolation of RU(tritox) 3 . The reaction of U(ditox) 4 with MeLi affords the addition product U(ditox) 4 (Me)Li, whose crystal structure is described. Preparation of uranium silox compounds is reported. 97 refs., 26 figs., 39 tabs

  14. Effect of halophilic conditions in stabilisation of RNA structure and function at high temperature under radiations. (United States)

    Maurel, M.-C.

    We have already shown the structural integrity of tRNA at high temperature - 82C for 30h - in high salt concentrations (Tehei et al, 2002). Stability were also performed by measuring the residual specific tRNA charge capacity after heat treatment for 30 h at 82C. RNA molecules are selected (in vitro selection) at high temperature at high salt concentration. We are undergoing studies of such molecules submitted to several stressful conditions, in particular high radiations. These studies provide support for the importance of salt to protect macromolecules against severe cosmic conditions. These could be useful for searching traces of life in planetary objects and space exploration. References : ElAmri, C., Baron, M-H., Maurel, M.-C. ``Adenine adsorption onto and release from meteorite specimens assessed by Surface Enhanced Raman Spectroscopy ''. Journal of Raman Spectroscopy (2004) in press. Meli, M., Vergne, J. and Maurel, M-C. "In vitro selection of adenine-dependent hairpin ribozymes" J. Biol. Chem., (2003), 278, 11, 9835-9842. ElAmri, C., Baron, M-H., Maurel, M.-C. ``Adenine in mineral samples : development of a methodology based on Surface Enhanced Raman Spectroscopy (SERS) for picomole detections ''. Spectrochimica Acta, A, 59, 2645-2654. Tehei, M., Franzetti, B., Maurel, M-C., Vergne, J., Hountondji, C. , Zaccai, G. ``Salt and the Search for Traces of Life '', Extremophiles, (2002), 6 : 427-430. Meli, M., Vergne, J., Décout, J.L., and Maurel, M-C. ``Adenine-Aptamer Complexes. A bipartite RNA site which binds the adenine nucleic base '', J. Biol. Chem., (2002), 277, 3, 2104-2111.

  15. Comparative study on diagonal equivalent methods of masonry infill panel (United States)

    Amalia, Aniendhita Rizki; Iranata, Data


    Infrastructure construction in earthquake prone area needs good design process, including modeling a structure in a correct way to reduce damages caused by an earthquake. Earthquakes cause many damages e.g. collapsed buildings that are dangerous. An incorrect modeling in design process certainly affects the structure's ability in responding to load, i.e. an earthquake load, and it needs to be paid attention to in order to reduce damages and fatalities. A correct modeling considers every aspect that affects the strength of a building, including stiffness of resisting lateral loads caused by an earthquake. Most of structural analyses still use open frame method that does not consider the effect of stiffness of masonry panel to the stiffness and strength of the whole structure. Effect of masonry panel is usually not included in design process, but the presence of this panel greatly affects behavior of the building in responding to an earthquake. In worst case scenario, it can even cause the building to collapse as what has been reported after great earthquakes worldwide. Modeling a structure with masonry panel as consideration can be performed by designing the panel as compression brace or shell element. In designing masonry panel as a compression brace, there are fourteen methods popular to be used by structure designers formulated by Saneinejad-Hobbs, Holmes, Stafford-Smith, Mainstones, Mainstones-Weeks, Bazan-Meli, Liauw Kwan, Paulay and Priestley, FEMA 356, Durani Luo, Hendry, Al-Chaar, Papia and Chen-Iranata. Every method has its own equation and parameters to use, therefore the model of every method was compared to results of experimental test to see which one gives closer values. Moreover, those methods also need to be compared to the open frame to see if they can result values within limits. Experimental test that was used in comparing all methods was taken from Mehrabi's research (Fig. 1), which was a prototype of a frame in a structure with 0.5 scale and the

  16. Ocular surface disease in patients with glaucoma or ocular hypertension treated with either BAK-preserved latanoprost or BAK-free travoprost

    Directory of Open Access Journals (Sweden)

    Gregory Katz


    Full Text Available Gregory Katz1, Clark L Springs2, E Randy Craven3, Michela Montecchi-Palmer41Huron Ophthalmology, Ypsilanti, MI, USA; 2Indiana University Eye Care, Indianapolis, IN, USA; 3Specialty Eye Care, Denver, CO, USA; 4Alcon Research Ltd., Fort Worth, TX, USAPurpose: The preservative benzalkonium chloride (BAK may adversely affect ocular surface health. This study evaluated symptoms of ocular surface disease (OSD in patients previously treated with a BAK-preserved therapy to lower their intraocular pressure, who either continued that therapy or switched to a BAK-free therapy.Methods: Eligible adult patients with ocular hypertension or open-angle glaucoma that had been controlled with BAK-preserved latanoprost 0.005% monotherapy (Xalatan® for at least one month and had a score of ≥ 13 (0 = none, 100 = most severe on the Ocular Surface Disease Index (OSDI questionnaire were entered into this prospective, double-masked, randomized, active-controlled, multicenter trial. By random assignment, patients either continued with BAK-preserved latanoprost 0.005% or transitioned to BAK-free travoprost 0.004% (Travatan Z® ophthalmic solution. OSDI scores were assessed again after six and 12 weeks.Results: For the 678 evaluable patients, mean change in OSDI score from baseline to week 12 favored the travoprost 0.004% BAK-free group, but was not statistically different between groups (P = 0.10. When patients with mild OSD at baseline were assessed after 12 weeks, the mean OSDI score was significantly lower (P = 0.04 in the BAK-free travoprost 0.004% group (score = 11.6 ± 10.8 units than in the BAK-preserved latanoprost 0.005% group (score = 14.4 ± 11.9 units, and a significantly larger percentage (P < 0.01 improved to normal OSDI scores in the BAK-free travoprost 0.004% group (62.9% of group than in the BAK-preserved latanoprost 0.005% group (47.0% of group. Patients pretreated with BAK-preserved latanoprost 0.005% for >24 months were significantly more likely (P

  17. Nanotechnology versus stem cell engineering: in vitro comparison of neurite inductive potentials

    Directory of Open Access Journals (Sweden)

    Morano M


    Full Text Available Michela Morano,1,* Sandra Wrobel,2,3,* Federica Fregnan,1 Ofra Ziv-Polat,4 Abraham Shahar,4 Andreas Ratzka,2 Claudia Grothe,2,3 Stefano Geuna,1 Kirsten Haastert-Talini2,3 1Department of Clinical and Biological Sciences, Università Degli Studi di Torino, Orbassano, Piemonte, Italy; 2Institute of Neuroanatomy, Hannover Medical School, Hannover, Lower-Saxony, Germany; 3Center for Systems Neuroscience (ZSN, Hannover, Lower-Saxony, Germany; 4NVR Research Ltd, Ness-Ziona, Israel *These authors contributed equally to this work and share first authorship Purpose: Innovative nerve conduits for peripheral nerve reconstruction are needed in order to specifically support peripheral nerve regeneration (PNR whenever nerve autotransplantation is not an option. Specific support of PNR could be achieved by neurotrophic factor delivery within the nerve conduits via nanotechnology or stem cell engineering and transplantation.Methods: Here, we comparatively investigated the bioactivity of selected neurotrophic factors conjugated to iron oxide nanoparticles (np-NTFs and of bone marrow-derived stem cells genetically engineered to overexpress those neurotrophic factors (NTF-BMSCs. The neurite outgrowth inductive activity was monitored in culture systems of adult and neonatal rat sensory dorsal root ganglion neurons as well as in the cell line from rat pheochromocytoma (PC-12 cell sympathetic culture model system.Results: We demonstrate that np-NTFs reliably support numeric neurite outgrowth in all utilized culture models. In some aspects, especially with regard to their long-term bioactivity, np-NTFs are even superior to free NTFs. Engineered NTF-BMSCs proved to be less effective in induction of sensory neurite outgrowth but demonstrated an increased bioactivity in the PC-12 cell culture system. In contrast, primary nontransfected BMSCs were as effective as np-NTFs in sensory neurite induction and demonstrated an impairment of neuronal differentiation in the PC-12

  18. Treatment of secondary hyperparathyroidism: the clinical utility of etelcalcetide

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    Cozzolino M


    Full Text Available Mario Cozzolino,1 Andrea Galassi,1 Ferruccio Conte,1 Michela Mangano,1 Luca Di Lullo,2 Antonio Bellasi1,3 1Department of Health Sciences, Renal Division, University of Milan, ASST Santi Paolo e Carlo, San Paolo Hospital, Milan, 2U.O.C. Nefrologia e Dialisi, Ospedale L. Parodi Delfino, Colleferro, Roma, 3Sant’Anna Hospital, ASST-Lariana, Como, Italy Abstract: Secondary hyperparathyroidism (SHPT, a very frequent, severe, and worsening complication of chronic kidney disease, is characterized by high serum parathyroid hormone (PTH, parathyroid gland hyperplasia, and disturbances in mineral metabolism. Clinically, SHPT shows renal osteodystrophy, vascular calcification, cardiovascular damage, and fatal outcome. Calcium-sensing receptor (CaSR is the main physiological regulator of PTH secretion; its activation by calcium rapidly inhibits PTH. Another important player in regulating mineral metabolism is vitamin D receptor (VDR, which is under the influence of vitamin D and influences the intestinal absorption of calcium and phosphate, PTH gene expression, and bone calcium mobilization. Serum phosphate levels influence fibroblast growth factor 23 (FGF-23 production, a phosphatonin that modulates serum phosphate reabsorption, PTH synthesis, and vitamin D production. Current therapeutic approaches consist of 1 phosphate intake control by diet or phosphate binders, 2 vitamin D by VDR activation, and 3 calcimimetic agents that activate CaSR. Recently, a new long-acting peptide (etelcalcetide belonging to the calcimimetics class was approved for intravenous use in hemodialysis patients with SHPT. Etelcalcetide binds directly to CaSR, by a sulfide bond, inhibiting the production and secretion of PTH by parathyroid glands. After intravenous administration in rats, etelcalcetide is quickly distributed to the tissues and eliminated by kidneys, while in uremic animals the nonrenal excretion is only 1.2%. In hemodialysis patients, the treatment itself is the

  19. Clinical evaluation of the efficacy and safety of a medical device in various forms containing Triticum vulgare for the treatment of venous leg ulcers – a randomized pilot study

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    Romanelli M


    Full Text Available Marco Romanelli,1 Michela Macchia,1 Salvatore Panduri,1 Battistino Paggi,1 Giorgio Saponati,2 Valentina Dini1 1Wound Healing Research Unit, Dermatology Division, Department of Clinical and Experimental Medicine, University of Pisa, 2ISPharm srl, Lucca, Italy Abstract: This study was carried out to assess the efficacy and tolerability of the topical application of an aqueous extract of Triticum vulgare (TV in different vehicles (cream, impregnated gauzes, foam, hydrogel, and dressing gel for the treatment of venous lower leg ulcers. Fifty patients were randomized to receive one of the five investigational vehicles. Treatment was performed up to complete healing or to a maximum of 29 days. The wound size reduction from baseline was the primary efficacy variable, which was measured by means of a noninvasive laser scanner instrument for wound assessment. In all groups, apart from the foam group, a similar trend toward the reduction of the surface area was observed. The cream showed the greatest effect on the mean reduction of the lesion size. At last visit, six ulcers were healed: two in the cream group, three in the gauze group, and one in the dressing gel group. In the patients treated with the cream, the gauzes, the hydrogel, and the dressing gel, the reduction of lesion size was 40%–50%; the reduction was smaller in the foam group. No impact in terms of age on the healing process was found. The Total Symptoms Score decreased in all groups during the study; a greater efficacy in terms of signs/symptoms was observed in the patients treated with the gauzes. In the dressing gel group, one patient had an infection of the wound after 3 weeks of treatment and 2 of colonization, leading to a systemic antibiotic treatment. The events were judged as nonrelated to the device used. On the basis of the results, it could be argued that the medical device may be useful in the treatment of chronic venous ulcers. Keywords: venous leg ulcers, Triticum vulgare

  20. Trauma. Die Spirale zwischenmenschlicher Gewalt aus feministisch-psychotherapeutischer Perspektive Trauma—The Spiral of Interpersonal Violence from a Feminist-Psychoanalytic Perspective

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    Christina Kleiser


    Full Text Available Die Psychotherapeutin Michaela Huber hat auf knapp sechshundert Seiten ein gleichermaßen sensibles wie engagiertes „Standardwerk“ der Traumabehandlung geschrieben. Die Zuerkennung dieser Auszeichnung durch das Österreichische Netzwerk für Traumatherapie erfolgt zu Recht. Vom Standpunkt der so genannten empathischen Abstinenz aus vermittelt Huber auf anspruchsvolle, doch durchweg gut verständliche Weise, wie ein Trauma entsteht und wirkt, was man sich unter einer Traumabehandlung vorzustellen hat und worauf es ankommt, wenn die komplexe Dynamik zwischen Täter, Täterin, Opfern und Überlebenden zwischenmenschlicher Gewalt durchbrochen werden soll. Geschrieben hat sie für Betroffene und deren Angehörige, für Fachkolleginnen und -kollegen sowie für alle in irgendeiner Form an der Thematik Interessierten. All jenen, die sich etwa aus philosophischer, kultur-, literatur-, geschichtswissenschaftlicher und/oder geschlechtertheoretischer Perspektive mit dem Phänomen des Traumas beschäftigen, seien die in zwei Teilbänden versammelten Erfahrungen, Erkenntnisse und Ergebnisse der jüngsten Psychotraumatologie als Grundlagenlektüre nahe gelegt.The psychotherapist Michela Huber has written an almost 600 page “standard work” of trauma therapy that is as sensitive as it is engaged. The deserved distinction was awarded by the Austrian Network for Trauma Therapy. From the standpoint of so-called empathetic abstinence, Huber explains in a demanding yet understandable manner how trauma occurs and what its effects are, what one can expect of trauma therapy and what needs to take place if the complex dynamic of interpersonal violence between perpetrator, victim, and survivor is to be broken. She wrote for victims and their families, for colleagues, and for all those who are interested in the subject in any form. The two-volume collection of the experiences, incite, and results of the most recent psychotraumatology is a strongly recommended read

  1. Illness denial questionnaire for patients and caregivers

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    Rossi Ferrario S


    Full Text Available Silvia Rossi Ferrario,1 Ines Giorgi,2 Paola Baiardi,3 Laura Giuntoli,4 Gianluigi Balestroni,1 Paola Cerutti,1 Marina Manera,2 Paola Gabanelli,2 Valentina Solara,5 Roberta Fornara,6 Michela Luisetti,1 Pierangela Omarini,1 Giovanna Omarini,1 Giulio Vidotto4 1Psychology Unit, Istituti Clinici Scientifici Maugeri SpA SB, Veruno, NO, Italy; 2Psychology Unit, 3Scientific Direction, Istituti Clinici Scientifici Maugeri SpA SB, Pavia, Italy; 4Department of General Psychology, University of Padova, Padova, Italy; 5Department of Neurology, ALS Centre, “Maggiore della Carita`” University Hospital, Novara, Italy; 6Psychology Unit, SS Trinità Hospital, Borgomanero, NO, Italy Purpose: Interest in assessing denial is still present, despite the criticisms concerning its definition and measurement. We tried to develop a questionnaire (Illness Denial Questionnaire, IDQ assessing patients’ and caregivers’ denial in relation to their illness/disturbance. Patients and methods: After a preliminary study, a final version of 24 dichotomous items (true/false was selected. We hypothesized a theoretical model with three dimensions: denial of negative emotions, resistance to change, and conscious avoidance, the first two composing the actual Denial and the last representing an independent component of the illness denial behavior. The IDQ was administered to 400 subjects (219 patients and 181 caregivers together with the Anxiety–Depression Questionnaire – Reduced form (AD-R, in order to assess concurrent validity. Confirmatory factor analysis (CFA, internal consistency indices (Cronbach’s α and McDonald’s ω, and test–retest analysis were performed. Results: CFA and internal consistency indices (Cronbach’s α: 0.87–0.96 indicated a clear and meaningful three-factor structure of IDQ, for both patients and caregivers. Further analyses showed good concurrent validity, with Denial and its subscale negatively associated with anxiety and depression and

  2. New strategies to ensure good patient–physician communication when treating adolescents and young adults with cancer: the proposed model of the Milan Youth Project

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    Magni MC


    Full Text Available Maria Chiara Magni,1 Laura Veneroni,1 Carlo Alfredo Clerici,2 Tullio Proserpio,3 Giovanna Sironi,1 Michela Casanova,1 Stefano Chiaravalli,1 Maura Massimino,1 Andrea Ferrari1 1Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy; 2Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; 3Pastoral Care Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy Abstract: Adolescence is a particularly complex time of life, entailing physiological, psychological, and social changes that further the individual's cognitive, emotional, and social growth. Being diagnosed with cancer at this time can have important consequences on an individual's emotional and physical development, and adolescent and young adult cancer patients have particular medical and psychosocial needs. Patient–physician communications are important in any clinical relationship, but fundamental in the oncological sphere because their quality can affect the patient–physician relationship, the therapeutic alliance, and patient compliance. A major challenge when dealing with adolescent and young adult patients lies in striking the right balance between their need and right to understand their disease, treatment, and prognosis, and the need for them to remain hopeful and to protect their emotional sensitivity. We herein describe the activities of the Youth Project of the Istituto Nazionale Tumori in Milan, Italy in order to share a possible model of interaction with these special patients and the tactics our group has identified to help them communicate and share their thoughts. This model implies not only the involvement of a multidisciplinary team, including psychologists and spirituality experts, but also the constitution of dedicated creative activities to give patients the opportunity to express feelings they would otherwise never feel at ease putting into words. These efforts seek the goal to minimize the potentially

  3. Monitoring diffuse degassing in monogentic volcanic field during magmatic reactivation: the case of El Hierro (Canary Islands, Spain) (United States)

    Morales-Ocaña, C.; Feldman, R. C.; Pointer, Z. R.; Rodríguez, F.; Asensio-Ramos, M.; Melián, G.; Padrón, E.; Hernández, P. A.; Pérez, N. M.


    El Hierro (278 km2), the younger, smallest and westernmost island of the Canarian archipelago, is a 5-km-high edifice constructed by rapid constructive and destructive processes in 1.12 Ma, with a truncated trihedron shape and three convergent ridges of volcanic cones. It experienced a submarine eruption from 12 October, 2011 and 5 March 2012, off its southern coast that was the first one to be monitored from the beginning in the Canary Islands. As no visible emanations occur at the surface environment of El Hierro, diffuse degassing studies have become a useful geochemical tool to monitor the volcanic activity in this volcanic island. Diffuse CO2 emission has been monitored at El Hierro Island since 1998 in a yearly basis, with much higher frequency in the period 2011-2012. At each survey, about 600 sampling sites were selected to obtain a homogeneous distribution. Measurements of soil CO2 efflux were performed in situ following the accumulation chamber method. During pre-eruptive and eruptive periods, the diffuse CO2 emission released by the whole island experienced significant increases before the onset of the submarine eruption and the most energetic seismic events of the volcanic-seismic unrest (Melián et al., 2014. J. Geophys. Res. Solid Earth, 119, 6976-6991). The soil CO2 efflux values of the 2017 survey ranged from non-detectable to 53.1 g m-2 d-1. Statistical-graphical analysis of the data show two different geochemical populations; background (B) and peak (P) represented by 77.6% and 22.4% of the total data, respectively, with geometric means of 1.8 and 9.2 g m-2 d-1, respectively. Most of the area showed B values while the P values were mainly observed at the interception center of the three convergent ridges and the north of the island. To estimate the diffuse CO2 emission for the 2017 survey, we ran about 100 sGs simulations. The estimated 2017 diffuse CO2 output released to atmosphere by El Hierro was at 1,150 ± 42 t d-1, value higher than the

  4. Eighteen years of geochemical monitoring at the oceanic active volcanic island of El Hierro (Canary Islands, Spain) (United States)

    Asensio-Ramos, María; Alonso, Mar; Sharp, Emerson; Woods, Hannah; Barrancos, José; Pérez, Nemesio M.


    We report herein the latest results of a diffuse CO2 efflux survey at El Hierro volcanic system carried out during the summer period of 2015 to constrain the total CO2 output from the studied area a during post-eruptive period. El Hierro Island (278 km2) is the youngest and the SW-most of the Canary Islands. On July 16, 2011, a seismic-volcanic crisis started with the occurrence of more than 11,900 seismic events and significant deformation along the island. On October 10, 2011, the dominant character of seismicity changed dramatically from discrete earthquakes to continuous tremor, a clear indication that magma was rapidly approaching the surface immediately before the onset of the eruption, October 12. Eruption was declared over on 5 March, 2012. In order to monitor the volcanic activity of El Hierro Island, from 1998 to 2015 diffuse CO2 emission studies have been performed at El Hierro volcanic system in a yearly basis (˜600 observation sites) according to the accumulation chamber method. Spatial distribution maps were constructed following the sequential Gaussian simulation (sGs) procedure. To quantify the total CO2 emission from the studied area, 100 simulations for each survey have been performed. During the eruption period, soil CO2 efflux values range from non-detectable (˜0.5 g m-2 d-1) up to 457 g m-2 d-1, reaching in November 27, 2011, the maximum CO2 output estimated value of all time series, 2,398 t d-1, just before the episodes of maximum degassing observed as vigorous bubbling at the sea surface and an increment in the amplitude of the tremor signal. During the 2015 survey, soil CO2 efflux values ranged from non-detectable up to 41 g m-2 d-1. The spatial distribution of diffuse CO2 emission values seemed to be controlled by the main volcano structural features of the island. The total diffuse CO2 output released to atmosphere was estimated at 575 ± 24 t d-1, value slightly higher that the background CO2 emission estimated at 422 t d-1 (Melián et

  5. Fermentation as a first step in carbon and nutrient recovery in regenerative life support systems (United States)

    Luther, Amanda; Lasseur, Christophe; Rebeyre, Pierre; Clauwaert, Peter; Rabaey, Korneel; Ronsse, Frederik; Zhang, Dong Dong; López Barreiro, Diego; Prins, Wolter


    Long term manned space missions, such as the establishment of a base on Mars, will require a regenerative means of supplying the basic resources (i.e., food, water, oxygen) necessary to support human life. The MELiSSA-loop is a closed loop compartmentalized artificial aquatic ecosystem designed to recover water, carbon, and nutrients from solid organic wastes (e.g., inedible food waste and feces) for the regeneration of food and oxygen for humans. The first step in this loop is a strictly anaerobic fermentation unit operated as a membrane bioreactor. In this step the aim is to maximize the hydrolysis of complex organic compounds into simple molecules (CO2, ammonia, volatile fatty acids, …) which can be consumed by plants and bacteria downstream to produce food again. Optimal steady state fermentation of a standardized homogeneous mixture of beets, lettuce, wheat straw, toilet paper, feces, and water was demonstrated to recover approximately 50% of the influent carbon as soluble organics in the effluent through anaerobic fermentation. Approximately 10% of the influent COD was converted to CO2, with the remaining ~40% retained as a mixture of undigested solids and biomass. Approximately 50% of the influent nitrogen was recovered in the effluent, 97% of which was in the form of ammonia. Similar results have been obtained at both lab and pilot scale. With only 10% of the carbon driven to CO2 through this fermentation, a major challenge at this moment for the MELiSSA-loop is closing the carbon cycle, by completely oxidizing the carbon in the organic waste and non-edible parts of the plant into CO2 for higher plants and algae to fix again for food production. To further improve the overall degradation we are investigating the integration of a high temperature and pressure, sub- or near critical water conditions to improve the degradation of fibrous material with the addition of an oxidant (hydrogen peroxide, H2O2) under sub- or near critical conditions to further

  6. Social y culturalmente ambiguos: criollos-mestizos de Tucumán, siglo XVII Socially and culturally ambiguous: criollo-mestizo population of Tucumán (Argentina, 17th century

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    Estela Noli


    Full Text Available Este artículo analiza la influencia de las sociedades indígenas sobre los descendientes de conquistadores españoles, los criollos. Se estudiará el caso de Juan Jordán de Trejo y los impedimentos presentados por una facción del cabildo de San Miguel de Tucumán a su admisión como teniente de gobernador. Este individuo descendía de una familia encomendera de Tafí, llamada Melián de Leguizamo y Guevara, pero pertenecía a una rama no favorecida del linaje y se desempeñaba como administrador de ese pueblo. Se indagará sobre las características de su mestizaje en el que destaca, a modo de espejo -de la españolización u occidentalización de los indios-, el manejo fluido de la lengua indígena, el conocimiento de las sociedades prehispánicas y sus territorios y el analfabetismo. Se analizará su rol como mediador interétnico (passeur culturel y las ventajas y obstáculos de este perfil en distintas coyunturas para el desempeño social y político en el grupo dominante.This article analyzes the influence of indigenous societies on the descendants of Spanish conquistadors, known as criollos. The subject is approached through a case study which shows how a faction of San Miguel de Tucumán town council (cabildo tried to prevent the admission of Juan Jordán de Trejo as deputy governor (teniente de gobernador. He belonged to the Melián de Leguizamo y Guevara family, owners of encomiendas in Tafí, but his lower lineage made him served as the town's administrator. Specific characteristics of his intercultural persona resembling a mirror image -referred to as Spanishization or Westernization of the Indians- will be studied, including his fluency in the indigenous language, his knowledge of pre-Hispanic societies and their territories and his illiteracy. His role as interethnic mediator (passeur culturel, and the advantages and drawbacks such a profile presents at different junctures, for social and political participation in the dominant

  7. Efeitos da aplicação tópica do mel de Melipona subnitida em feridas infectadas de ratos

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    Diego Felipe Sampaio Alves

    Full Text Available OBJETIVO: Avaliar efeitos do uso tópico do mel da abelha silvestre Melipona subnitida na evolução de feridas infectadas de pele. MÉTODO: Ratos Wistar foram distribuídos aleatoriamente em grupos de 6, anestesiados com tiopental sódico 20mg/Kg IP e cetamina 30mg/Kg IM e submetidos a exérese de segmento de 1 cm² de pele total do dorso. Os ratos do grupo C (não infectado foram tratados com solução salina sobre a ferida diariamente e no grupo MEL (não infectado as feridas foram tratadas com mel uma vez por dia. Nos grupos C/I e MEL/I as feridas foram inoculadas com solução polimicrobiana. Culturas foram feitas 24 horas após. Caracterizada a infecção, as feridas foram tratadas com solução salina e mel, respectivamente. No terceiro dia de tratamento foi feita nova cultura. Após epitelização foi contado o tempo de cicatrização e as feridas foram biopsiadas para histopatologia e dosagem de TNF-α, IL-1β e IL-6 no tecido. RESULTADOS: O tempo médio de cicatrização do grupo MEL/I foi menor que nos demais grupos (P<0,05. Verificou-se que a densidade de colágeno, leucócitos, fibroblastos e dosagem de citocinas (especialmente TNF foi maior no grupo infectado e tratado com mel que nos demais grupos. Houve significante redução de bactérias Gram-negativas e positivas nas feridas após o tratamento com mel. CONCLUSÃO: O uso tópico de mel de Melipona subnitida em feridas infectadas da pele de ratos estimulou a resposta imunológica, reduziu a infecção e o tempo de cicatrização.

  8. Preliminary investigations of the rhizosphere nature of hydroponically grown lettuces (United States)

    Antunes, Inês; Paille, Christel; Lasseur, Christophe

    Due to capabilities of current launchers, future manned exploration beyond the Earth orbit will imply long journeys and extended stays on planet surfaces. For this reason, it is of a great importance to develop a Regenerative Life Support System that enables the crew to be, to a very large extent, metabolic consumables self-sufficient. In this context, the European Space Agency, associated with a scientific and engineering con-sortium, initiated in 1989 the Micro-Ecological Life Support System Alternative (MELiSSA) project. This concept, inspired on a terrestrial ecosystem (i.e. a lake), comprises five intercon-nected compartments inhabited by micro-organisms and higher-plants aiming to produce food, fresh water, and oxygen from organic waste, carbon dioxide, and minerals. Given the important role of the higher-plant compartment for the consumption of carbon dioxide and the production of oxygen, potable water, and food, it was decided to study the microbial communities present in the root zone of the plants (i.e. the rhizosphere), and their synergistic and antagonistic influences in the plant growth. This understanding is important for later investigations concerning the technology involved in the higher plant compartment, since the final goal is to integrate this compartment inside the MELiSSA loop and to guarantee a healthy and controlled environment for the plants to grow under reduced-gravity conditions. To perform a preliminary assessment of the microbial populations of the root zone, lettuces were grown in a hydroponic system and their growth was characterized in terms of nutrient uptake, plant diameter, and plant wet and dry weights. In parallel, the microbial population, bacteria and fungi, present in the hydroponic medium and also inside and outside the roots were analyzed in terms of quantity and nature. The goal of this presentation is to give a preliminary review in the plant root zone of the micro-organisms communities and as well their proportions

  9. Synthesis of mono- and geminal dimetalated carbanions of bis(phenylsulfonyl)methane using alkali metal bases and structural comparisons with lithiated bis(phenylsulfonyl)imides. (United States)

    MacDougall, Dugald J; Kennedy, Alan R; Noll, Bruce C; Henderson, Kenneth W


    The alpha,alpha'-stabilized carbanion complexes [(PhSO2)2CHLi.THF]1, [(PhSO2)2CHNa.THF]2 and [(PhSO2)2CHK]3 were prepared by the direct deprotonation of bis(phenylsulfonyl)methane I in THF with one molar equivalent of MeLi, BuNa and BnK respectively. The geminal dianionic complexes [(PhSO2)2CLi2.THF]4, [(PhSO2)2CNa2.0.55THF]5 and [(PhSO2)2CK2]6 were similarly prepared by the reaction of I with two molar equivalents of MeLi, BuNa and BnK respectively in THF. NMR and MS solution studies of 1-3 are consistent with the formation of charge-separated species in DMSO media. Solutions studies of 4-6, in conjunction with trapping experiments, indicate that the dianions deprotonate DMSO and regenerate the monoanions 1-3. Crystallographic analysis of 1 revealed a 1D chain polymer in which the metal centers are chelated by the bis(sulfonyl) ligands and connect to neighboring units through Li-O(S) interactions. An unexpected feature of 1 is that the polymeric chains are homochiral, since the chelating ligands of the backbone adopt the same relative configuration. Also, the phenyl substituents of each chelate in 1 are oriented in a cisoid manner. The sodium derivative 2 adopts a related solid-state structure, where enantiomeric pairs of chains combine to give a 1D ribbon motif. The lithium bis(phenylsulfonyl)imides [(PhSO2)2NLi.THF]9 and [(PhSO2)2NLi.Pyr2]10 were also prepared and structurally characterized. In the solid state 9 has a similar connectivity to that found for 1 but with heterochiral chains. In comparison, the more highly solvated complex 10 forms a 1D polymeric arrangement without chelation of the ligands and with the phenyl substituents oriented in a transoid fashion.

  10. Early steroid sulfurization in surface sediments of a permanently stratified lake (Ace Lake, Antarctica) (United States)

    Kok, Marika D.; Rijpstra, W. Irene C.; Robertson, Lisette; Volkman, John K.; Sinninghe Damstéé, Jaap S.


    Surface sediments (0-25 cm) from Ace Lake (eastern Antarctica), a saline euxinic lake, were analyzed to study the early incorporation of reduced inorganic sulfur species into organic matter. The apolar fractions were shown to consist predominantly of dimeric (poly)sulfide linked C 27-C 29 steroids. These steroid moieties were identified by GC-MS analysis of the apolar fractions after cleavage of polysulfide linkages using MeLi and MeI and after desulfurisation. The polar fractions contained the oligomeric analogues. The S-bound steroids are most likely formed by sulfur incorporation into steroidal ketones formed from Δ 5 sterols by biohydrogenation by anaerobic bacteria. The concentrations of these sulfurised steroids increased with depth in the sediment. The sulfurisation reaction is completed in 1000-3000 years. Despite a wide range of functionalised lipids present in these sediments that are potentially available for sulfurisation, there is a very strong preference for the incorporation of sulfur into steroidal compounds. A predominance of sulfurised C 27 steroids contrasted with the distribution of free sterols, which showed a strong predominance of C 29 sterols. This indicates that the incorporation of sulfur is biased towards C 27 sterols. The results demonstrate that intermolecular sulfurisation of organic matter can occur in surface sediments at low temperatures and in the absence of light.

  11. Fenntarthatóság a beszerzésben = Sustainable purchasing


    Vörösmarty, Gyöngyi; Dobos, Imre


    Tanulmányunk a fenntarthatóság beszerzésben való értelmezésével kapcsolatos vizsgálatához szeretne hozzájárulni. A Versenyképesség Kutatás korábbi fázisában a fenntarthatóság beszerzésben való megjelenésével, lehetséges értelmezéseivel, tartalmi elemeivel, azok strukturálásával és azokkal a motivációs tényezőkkel foglalkoztunk, mely a kezdeményezések hátterében állt. Az akkori eredményekre építve szeretnénk a témát folytatni. Áttekintjük a szakirodalom legutóbbi elemzésünk óta született eredm...

  12. Modelo para la Predicción Energética de una Instalación Hotelera

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    Adriana V. Acosta


    Full Text Available Resumen: Este artículo describe la obtención y validación de un modelo de predicción energética para el hotel Meliá Habana de la ciudad Habana en Cuba. El modelo obtenido emplea el método de series de tiempo radiantes para la determinación de la carga térmica de los bloques habitacionales de la instalación. El modelo es implementado en el lenguaje de programación MatLab®. La validación experimental del modelo se realiza con mediciones reales del consumo energético diario del hotel. El valor de uso del modelo obtenido es apreciable para estudios de comportamiento energético y para la implementación de estrategias avanzadas de control. Palabras clave: Modelado, Control de la Energía, Coeficientes de Temperatura, Validación

  13. A metabolomics strategy to assess the combined toxicity of polycyclic aromatic hydrocarbons (PAHs) and short-chain chlorinated paraffins (SCCPs). (United States)

    Wang, Feidi; Zhang, Haijun; Geng, Ningbo; Ren, Xiaoqian; Zhang, Baoqin; Gong, Yufeng; Chen, Jiping


    The combined toxicity of mixed chemicals is usually evaluated according to several specific endpoints, and other potentially toxic effects are disregarded. In this study, we provided a metabolomics strategy to achieve a comprehensive understanding of toxicological interactions between mixed chemicals on metabolism. The metabolic changes were quantified by a pseudotargeted analysis, and the types of combined effects were quantitatively discriminated according to the calculation of metabolic effect level index (MELI). The metabolomics strategy was used to assess the combined effects of polycyclic aromatic hydrocarbons (PAHs) and short-chain chlorinated paraffins (SCCPs) on the metabolism of human hepatoma HepG2 cells. Our data suggested that exposure to a combination of PAHs and SCCPs at human internal exposure levels could result in an additive effect on the overall metabolism, whereas diverse joint effects were observed on various metabolic pathways. The combined exposure could induce a synergistic up-regulation of phospholipid metabolism, an additive up-regulation of fatty acid metabolism, an additive down-regulation of tricarboxylic acid cycle and glycolysis, and an antagonistic effect on purine metabolism. SCCPs in the mixture acted as the primary driver for the acceleration of phospholipid and fatty acid metabolism. Lipid metabolism disorder caused by exposure to a combination of PAHs and SCCPs should be an important concern for human health. Copyright © 2017 Elsevier Ltd. All rights reserved.

  14. Working with Space and Shape in Early Childhood Education: Experiences in Collaboration

    Directory of Open Access Journals (Sweden)

    Karina Luiza da Silva Fernandes


    Full Text Available This report shows the experience of a work conducted with the Meli-Melo puzzle in two early childhood education classes at two different schools in the state of São Paulo, Brazil. With the work’s activities as a starting point, aspects related to space and shape, as well as quantities and measures, were approached. Children from two and a half to five years old participated in the playful activities, which had the following goals: to develop spatial and geometric skills, to allow measuring actions, to favor dialogue and to boost group work experience. There were several activities, like handling the pieces, assembling images freely or according with outlines and models, assembling three-dimensional figures, and the length game. The following questions were considered in the evaluation of the work: how was the children’s participation in large groups and small groups? How did children of different age groups engage in the different proposals? Which activities were easier or more difficult for each group? Which behaviors and conversations showed us new knowledge? The fulfillment of the planned activities showed that the children had several hypotheses regarding shapes and that they were able to identify similarities and differences, use geometry vocabulary, and discuss their thoughts, particularly when working in small groups, which favored the participation of nearly all children. We believe the work reported has allowed learnings and a contact with mathematics in early childhood education.

  15. Cyanobacteria to Link Closed Ecological Systems and In-Situ Resources Utilization Processes (United States)

    Brown, Igor

    Introduction: A major goal for the Vision of Space Exploration is to extend human presence across the solar sys-tem. With current technology, however, all required consumables for these missions (propellant, air, food, water) as well as habitable volume and shielding to support human explorers will need to be brought from Earth. In-situ pro-duction of consumables (In-Situ Resource Utilization-ISRU) will significantly facilitate current plans for human ex-ploration and colonization of the solar system, especially by reducing the logistical overhead such as recurring launch mass. The production of oxygen from lunar materials is generally recognized as the highest priority process for lunar ISRU, for both human metabolic and fuel oxidation needs. The most challenging technology developments for future lunar settlements may lie in the extraction of elements (O, Fe, Mn, Ti, Si, etc) from local rocks and soils for life support, industrial feedstock and the production of propellants. With few exceptions (e.g., Johannson, 1992), nearly all technology development to date has employed an ap-proach based on inorganic chemistry (e.g. Allen et al., 1996). None of these technologies include concepts for inte-grating the ISRU system with a bioregenerative life support system and a food production systems. Bioregenerative life support efforts have recently been added to the Constellation ISRU development program (Sanders et al, 2007). Methods and Concerns: The European Micro-Ecological Life Support System Alternative (MELiSSA) is an ad-vanced concept for organizing a bioregenerative system for long term space flights and extraterrestrial settlements (Hendrickx, De Wever et al., 2005). However the MELiSSA system is a net consumer of ISRU products without a net return to in-situ technologies, e.g.. to extract elements as a result of complete closure of MELiSSA. On the other hand, the physical-chemical processes for ISRU are typically massive (relative to the rate of oxygen

  16. Proteome-wide analysis and diel proteomic profiling of the cyanobacterium Arthrospira platensis PCC 8005.

    Directory of Open Access Journals (Sweden)

    Sabine Matallana-Surget

    Full Text Available The filamentous cyanobacterium Arthrospira platensis has a long history of use as a food supply and it has been used by the European Space Agency in the MELiSSA project, an artificial microecosystem which supports life during long-term manned space missions. This study assesses progress in the field of cyanobacterial shotgun proteomics and light/dark diurnal cycles by focusing on Arthrospira platensis. Several fractionation workflows including gel-free and gel-based protein/peptide fractionation procedures were used and combined with LC-MS/MS analysis, enabling the overall identification of 1306 proteins, which represents 21% coverage of the theoretical proteome. A total of 30 proteins were found to be significantly differentially regulated under light/dark growth transition. Interestingly, most of the proteins showing differential abundance were related to photosynthesis, the Calvin cycle and translation processes. A novel aspect and major achievement of this work is the successful improvement of the cyanobacterial proteome coverage using a 3D LC-MS/MS approach, based on an immobilized metal affinity chromatography, a suitable tool that enabled us to eliminate the most abundant protein, the allophycocyanin. We also demonstrated that cell growth follows a light/dark cycle in A. platensis. This preliminary proteomic study has highlighted new characteristics of the Arthrospira platensis proteome in terms of diurnal regulation.

  17. Growth modelling of Nitrosomonas europaea ATCC® 19718 and Nitrobacter winogradskyi ATCC® 25391: A new online indicator of the partial nitrification. (United States)

    Cruvellier, Nelly; Poughon, Laurent; Creuly, Catherine; Dussap, C-Gilles; Lasseur, Christophe


    The aim of the present work was to study the growth of two nitrifying bacteria. For modelling the nitrifying subsystem of the MELiSSA loop, Nitrosomonas europaea ATCC® 19718 and Nitrobacter winogradskyi ATCC® 25931 were grown separately and in cocultures. The kinetic parameters of a stoichiometric mass balanced Pirt model were identified: μmax=0.054h(-1), decay rate b=0.003h(-1) and maintenance rate m=0.135gN-NH4(+)·gX(-1)·h(-1) for Nitrosomonas europaea; μmax=0.024h(-1), b=0.001h(-1) and m=0.467gN-NO2(-)·gX(-1)·h(-1) for Nitrobacter winogradskyi. A predictive structured model of nitrification in co-culture was developed. The online evolution of the addition of KOH is correlated to the nitritation; the dissolved oxygen concentration is correlated to both nitritation and nitratation. The model suitably represents these two variables so that transient partial nitrification is assessed. This is a clue for avoiding partial nitrification by predictive functional control. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. Huellas del universo guaraní en la memoria escrita del paraguayo Augusto Roa Bastos

    Directory of Open Access Journals (Sweden)

    Paco Tovar Blanco


    Full Text Available Marcel Dominguez (1868-1936 wrote on the history of Paraguay, valuing the traces of the indigenous peoples; Eloy Fariña Núñez (1885-1929 interpreted the poetic dimensions of the Guaraní universe, composing the "Secular Canto"; The anthropologists Kurt Unkel (1883-1945, Leon Cadogan (1899-1973 and Bertomeu Meliá (1932 showed an interest in those same people, exploring their roots and ways of life. In Augusto Roa Bastos’ works, an awareness of historical order, similar poetic dimensions and human reach is once again represented. All this is done through a language where, without "alibis or civilizing betrayals", he tells the good use of myths, allowing us to read the reality, all our reality. The genesis of the Guarani (1948, Son of Man (1960, (1993 confirm Roa’s success, a writer who speaks of his Guaraní legacy, Yo el Supremo (1974 and El Fiscal handles from his writing a colonial heritage and expiate with words of a common language the memory of Miguel Vera, the records of an anonymous compiler and the notes of the outlaw Felix Moral.

  19. A multiple index integrating different levels of organization. (United States)

    Cortes, Rui; Hughes, Samantha; Coimbra, Ana; Monteiro, Sandra; Pereira, Vítor; Lopes, Marisa; Pereira, Sandra; Pinto, Ana; Sampaio, Ana; Santos, Cátia; Carrola, João; de Jesus, Joaquim; Varandas, Simone


    Many methods in freshwater biomonitoring tend to be restricted to a few levels of biological organization, limiting the potential spectrum of measurable of cause-effect responses to different anthropogenic impacts. We combined distinct organisational levels, covering biological biomarkers (histopathological and biochemical reactions in liver and fish gills), community based bioindicators (fish guilds, invertebrate metrics/traits and chironomid pupal exuviae) and ecosystem functional indicators (decomposition rates) to assess ecological status at designated Water Framework Directive monitoring sites, covering a gradient of human impact across several rivers in northern Portugal. We used Random Forest to rank the variables that contributed more significantly to successfully predict the different classes of ecological status and also to provide specific cut levels to discriminate each WFD class based on reference condition. A total of 59 Biological Quality Elements and functional indicators were determined using this procedure and subsequently applied to develop the integrated Multiple Ecological Level Index (MELI Index), a potentially powerful bioassessment tool. Copyright © 2016 Elsevier Inc. All rights reserved.

  20. 8th European Conference on Rare Diseases & Orphan Products (ECRD 2016

    Directory of Open Access Journals (Sweden)

    Michael Schlander


    Full Text Available Table of contents O1 The European Social Preferences Measurement (ESPM study project: social cost value analysis, budget impact, commercial life cycle revenue management, and the economics of biopharmaceutical Research & Development (R&D Michael Schlander, Søren Holm, Erik Nord, Jeff Richardson, Silvio Garattini, Peter Kolominsky-Rabas, Deborah Marshall, Ulf Persson, Maarten Postma, Steven Simoens, Oriol de Solà Morales, Keith Tolley, Mondher Toumi, Harry Telser O2 Newborn Screening: the potential and the challenges James R Bonham O3 Untreatable disease outcomes - how would we measure them? Helmut Hintner, Anja Diem, Martin Laimer O4 Taking Integrated Care Forward: Experiences from Canada to inspire service provision for people living with rare disease in Europe Réjean Hébert O5 Listening to the patient’s voice: social media listening for safety and benefits in rare diseases Nabarun Dasgupta, Carrie E. Pierce, Melissa Jordan O6 Via Opta: Mobile apps making visually impaired patients’ lives easier Barbara Bori, Mohanad Fors, Emilie Prazakova O7 A report of the IRDiRC “Small Population Clinical Trial” Task Force Simon Day O8 HAE patient identification and diagnosis: An innovative, ‘game changing’ collaboration Thomas J. Croce Jr. O9 Co-creating with the community: primary packaging & administration for people with haemophilia Jonas Fransson, Philip Wood O10 Go with Gaucher, taking forward the next generation. How to involve young people to create a new generation of patient advocates Anne-Grethe Lauridsen, Joanne Higgs, Vesna Stojmirova Aleksovska P1 ODAK – Orphan Drug for Acanthamoeba Keratitis Christina Olsen, Ritchie Head, Antonio Asero, Vincenzo Papa, Christa van Kan, Loic Favennec, Silvana Venturella, Michela Salvador, Alan Krol P5 Rare Navigators help people living with rare diseases to manage the social – and healthcare systems Stephanie J. Nielsen, Birthe B. Holm P6 The eAcademy for Tay-Sachs & Sandhoff disease app

  1. Diffuse degassing He/CO2 ratio before and during the 2011-12 El Hierro submarine eruption, Canary Islands (United States)

    Padrón, Eleazar; Hernández, Pedro A.; Melián, Gladys V.; Barrancos, José; Padilla, Germán; Pérez, Nemesio M.; Dionis, Samara; Rodríguez, Fátima; Asensio-Ramos, María; Calvo, David


    El Hierro Island (278 km2) is the youngest and the SW-most of the Canary Islands. On July 16, 2011, a seismic-volcanic crisis started with the occurrence of more than 11,900 seismic events and significant deformation along the island, culminating with the eruption onset in October 12. Since at El Hierro Islands there are not any surface geothermal manifestation (fumaroles, etc), we have focused our studies on soil degassing surveys. Between July 2011 to March 2012, seventeen diffuse CO2 and He emissions soil gas surveys were undertaken at El Hierro volcanic system (600 observation sites) with the aim to investigate the relationship between their temporal variations and the volcanic activity (Padrón et al., 2013; Melián et al., 2014). Based on the diffuse He/CO2 emission ratio, a sharp increase before the eruption onset was observed, reaching the maximum value on September 26 (6.8×10-5), sixteen days before the occurrence of the eruption. This increase coincided with an increase in seismic energy release during the volcanic unrest and occurred together with an increase on the 3He/4He isotopic ratio in groundwaters from a well in El Hierro Island (Padrón et al., 2013; from 2-3 RA to 7.2 RA where RA = 3He/4He ratio in air), one month prior to the eruption onset. Early degassing of new gas-rich magma batch at depth could explain the observed increase on the He/CO2 ratio, causing a preferential partitioning of CO2 in the gas phase with respect to the He, due to the lower solubility of CO2 than that of He in basaltic magmas. During the eruptive period (October 2011-March 2012) the prevalence of a magmatic CO2-dominated component is evident, as indicated by the generally lower He/CO2 ratios and high 3He/4He values (Padrón et al., 2013). The onset of the submarine eruption might have produced a sudden release of volcanic gases, and consequently, a decrease in the volcanic gas pressure of the magma bodies moving beneath the island, reflected by a drastic decrease in

  2. Diffuse CO_{2} degassing monitoring of the oceanic active volcanic island of El Hierro, Canary Islands, Spain (United States)

    Hernández, Pedro A.; Norrie, Janice; Withoos, Yannick; García-Merino, Marta; Melián, Gladys; Padrón, Eleazar; Barrancos, José; Padilla, Germán; Rodríguez, Fátima; Pérez, Nemesio M.


    one, between October 24 and November 27, 2011, before the most energetic seismic events of the volcanic-seismic unrest (Melián et al., 2014. J. Geophys. Res. Solid Earth, 119, 6976-6991). The highest CO2 degassing rate measured in the last three years (1684 t/d) was observed during a seismo-volcanic unrest. This value decreased until close to background value (˜422 t/d, Melián et al., 2014) contemporaneously with the decline of the seismic activity during the first half of 2013. The last diffuse CO2 degassing survey was carried out in the summer of 2016, showing a emission rate of 854 t/d. Discrete surveys of diffuse CO2 emission have provided important information to optimize the early warning system in the volcano monitoring programs of El Hierro and to monitor the evolution of an ongoing volcanic eruption, even though is a submarine eruption.

  3. O trabalho com espaço e forma na educação infantil: Experiências em colaboração

    Directory of Open Access Journals (Sweden)

    Karina Luiza da Silva Fernandes


    Full Text Available This report shows the experience of a work conducted with the Meli-Melo puzzle in two early childhood education classes at two different schools in the state of São Paulo, Brazil. With the work’s activities as a starting point, aspects related to space and shape, as well as quantities and measures, were approached. Children from two and a half to five years old participated in the playful activities, which had the following goals: to develop spatial and geometric skills, to allow measuring actions, to favor dialogue and to boost group work experience. There were several activities, like handling the pieces, assembling images freely or according with outlines and models, assembling three-dimensional figures, and the length game. The following questions were considered in the evaluation of the work: how was the children’s participation in large groups and small groups? How did children of different age groups engage in the different proposals? Which activities were easier or more difficult for each group? Which behaviors and conversations showed us new knowledge? The fulfillment of the planned activities showed that the children had several hypotheses regarding shapes and that they were able to identify similarities and differences, use geometry vocabulary, and discuss their thoughts, particularly when working in small groups, which favored the participation of nearly all children. We believe the work reported has allowed learnings and a contact with mathematics in early childhood education. Este relato apresenta a experiência de um trabalho com o quebra-cabeça “Meli-Melô” em duas turmas de educação infantil em Unidades Educacionais do interior de São Paulo, Brasil. A partir das atividades, trabalhamos aspectos relativos a espaço e forma e grandezas e medidas. As propostas de caráter lúdico foram realizadas com crianças de dois anos e meio a cinco anos, tendo como objetivos: desenvolver habilidades espaciais e geom

  4. Molecular exploration of the highly radiation resistant cyanobacterium Arthrospira sp. PCC 8005 (United States)

    Badri, Hanène; Leys, Natalie; Wattiez, Ruddy

    Arthrospira (Spirulina) is a photosynthetic cyanobacterium able to use sunlight to release oxygen from water and remove carbon dioxide and nitrate from water. In addition, it is suited for human consumption (edible). For these traits, the cyanobacterium Arthrospira sp. PCC 8005 was selected by the European Space Agency (ESA) as part of the life support system MELiSSA for recycling oxygen, water, and food during future long-haul space missions. However, during such extended missions, Arthrospira sp. PCC 8005 will be exposed to continuous artificial illumination and harmful cosmic radiation. The aim of this study was to investigate how Arthrospira will react and behave when exposed to such stress environment. The cyanobacterium Arthrospira sp. PCC 8005 was exposed to high gamma rays doses in order to unravel in details the response of this bacterium following such stress. Test results showed that after acute exposure to high doses of 60Co gamma radiation upto 3200 Gy, Arthrospira filaments were still able to restart photosynthesis and proliferate normally. Doses above 3200 Gy, did have a detrimental effect on the cells, and delayed post-irradiation proliferation. The photosystem activity, measured as the PSII quantum yield immediately after irradiation, decreased significantly at radiation doses above 3200 Gy. Likewise through pigment content analysis a significant decrease in phycocyanin was observed following exposure to 3200 Gy. The high tolerance of this bacterium to 60Co gamma rays (i.e. ca. 1000x more resistant than human cells for example) raised our interest to investigate in details the cellular and molecular mechanisms behind this amazing resistance. Optimised DNA, RNA and protein extraction methods and a new microarray chip specific for Arthrospira sp. PCC 8005 were developed to identify the global cellular and molecular response following exposure to 3200 Gy and 5000 Gy A total of 15,29 % and 30,18 % genes were found differentially expressed in RNA

  5. Low Earth orbit journey and ground simulations studies point out metabolic changes in the ESA life support organism Rhodospirillum rubrum (United States)

    Mastroleo, Felice; Leys, Natalie; Benotmane, Rafi; Vanhavere, Filip; Janssen, Ann; Hendrickx, Larissa; Wattiez, Ruddy; Mergeay, Max

    MELiSSA (Micro-Ecological Life Support System Alternative) is a project of closed regenerative life support system for future space flights developed by the European Space Agency. It consists of interconnected processes (i.e. bioreactors, higher plant compartments, filtration units,..) targeting the total recycling of organic waste into oxygen, water and food. Within the MELiSSA loop, the purple non-sulfur alpha-proteobacterium R. rubrum ATCC25903 is used to convert fatty acids released from the upstream raw waste digesting reactor to CO2 and biomass, and to complete the mineralization of aminoacids into NH4+ that will be forwarded to the nitrifying compartment. Among the numerous challenges of the project, the functional stability of the bioreactors in long term and under space flight conditions is of paramount importance for the efficiency of the life support system and consequently the crew safety. Therefore, the physiological and metabolic changes induced by space flight were investigated for R. rubrum. The bacterium grown on solid medium during 2 different 10-day space flights to the ISS (MES- SAGE2, BASE-A experiments) were compared to cells grown on Earth 1 g gravity or modeled microgravity and normal Earth radiation or simulated space flight radiation conditions in order to relate each single stress to its respective cellular response. For simulating the radiation environment, pure gamma and neutron sources were combined, while simulation of changes in gravity where performed using the Random Positioning Machine technology. Transcriptome analysis using R. rubrum total genome DNA-chip showed up-regulation of genes involved in oxidative stress response after a 10-day mission inside the ISS, without loss of viability. As an example, alkyl hydroperoxide reductase, thioredoxin reductase and bacterioferritin genes are least 2 fold induced although the radiation dose experienced by the bacterium (4 mSv) is very low compared to its radiotolerance (D10 = 100 Sv


    Directory of Open Access Journals (Sweden)

    Alfredo Eugenio Leal Santana


    Full Text Available El presente trabajo constituye la concepción y realización de un esquema de conmutaciónautomática de líneas de entrada al ocurrir fallas en ellas, basado en autómatas programablesy aplicable principalmente a subestaciones del tipo distribuidoras aunque puede serimplementado en otros tipos de subestaciones para otros esquemas de conmutación. Elesquema permite además la reconfiguración automática al restablecerse el servicio normala la subestación.Se implementa además la posibilidad del control remoto del esquema como elementosubordinado al actual Sistema de Telemando o del SCADA pudiendo además serimplementado en el futuro como parte de cualquiera de estos Sistemas.La implementación de estos esquemas permite una mayor confiabilidad en la operación delas instalaciones y una mayor seguridad y rapidez en la conmutación de las líneas lo queeleva la calidad del servicio que se brinda a los consumidores. La utilización de autómatasprogramables permite una mejor coordinación con las automáticas propias de los consumidorese incluso la posibilidad de que futuros clientes puedan decidir la inclusión o no de estasautomáticas propias en sus nuevas inversiones.Este esquema se encuentra instalado y en servicio desde el mes de abril del presente año enla subestación distribuidora Monte Barreto, la cual brinda servicio a una extensa zona turísticay de negocios con instalaciones como los hoteles Comodoro, Meliá Havana, Neptuno-Tritóne inmobiliarias arrendadas a instituciones extranjeras.  The present paper constitutes the conception and realization of a layout for the automaticcommutation of entrance lines when happening faults in them, based on ProgrammableLogic Controller and applicable mainly to substations of the type distributors, although itcan be implemented in other types of substations for other commutation layouts. This onealso allows the automatic reconfiguration when recovering the normal service to thesubstation.It is

  7. Subcritical and supercritical water oxidation of organic, wet wastes for carbon cycling in regenerative life support systems (United States)

    Ronsse, Frederik; Lasseur, Christophe; Rebeyre, Pierre; Clauwaert, Peter; Luther, Amanda; Rabaey, Korneel; Zhang, Dong Dong; López Barreiro, Diego; Prins, Wolter; Brilman, Wim


    For long-term human spaceflight missions, one of the major requirements is the regenerative life support system which has to be capable of recycling carbon, nutrients and water from both solid and liquid wastes generated by the crew and by the local production of food through living organisms (higher plants, fungi, algae, bacteria, …). The European Space Agency's Life Support System, envisioned by the MELiSSA project, consists of a 5 compartment artificial ecosystem, in which the waste receiving compartment (so-called compartment I or briefly 'CI') is based on thermophilic fermentation. However, as the waste generated by the crew compartment and food production compartment contain typical plant fibres (lignin, cellulose and hemicellulose), these recalcitrant fibres end up largely unaffected in the digestate (sludge) generated in the C-I compartment. Therefore, the C-I compartment has to be supplemented with a so-called fibre degradation unit (in short, FDU) for further oxidation or degradation of said plant fibres. A potential solution to degrading these plant fibres and other recalcitrant organics is their oxidation, by means of subcritical or supercritical water, into reusable CO2 while retaining the nutrients in an organic-free liquid effluent. By taking advantage of the altered physicochemical properties of water above or near its critical point (647 K, 22.1 MPa) - including increased solubility of non-polar compounds and oxygen, ion product and diffusivity - process conditions can be created for rapid oxidation of C into CO2. In this research, the oxidizer is provided as a hydrogen peroxide solution which, at elevated temperature, will dissociated into O2. The purpose of this study is to identify ideal process conditions which (a) ensure complete oxidation of carbon, (b) retaining the nutrients other than C in the liquid effluent and (c) require as little oxidizer as possible. Experiments were conducted on a continuous, tubular heated reactor and on batch

  8. An extremely bulky tris(pyrazolyl)methanide: a tridentate ligand for the synthesis of heteroleptic magnesium(II) and ytterbium(II) alkyl, hydride, and iodide complexes. (United States)

    Lalrempuia, Ralte; Stasch, Andreas; Jones, Cameron


    The tris(pyrazolyl)methane compound HC(3-Ad-5-Mepz)3 [1, 3-Ad-5-Mepz=3-(1-adamantyl)-5-methylpyrazolyl] and its regioisomer, HC(3-Ad-5-Mepz)2 (3-Me-5-Adpz), were synthesized and crystallographically characterized. Deprotonation of 1 with MeLi afforded the lithium complex [{κ(3) -N-C(3-Ad-5-Mepz)3 }Li(thf)], which incorporates a tris(pyrazolyl)methanide ligand of unprecedented bulk. Reaction of 1 with MeMgI gave the ionic coordination complex [{κ(3) -N-HC(3-Ad-5-Mepz)3 }MgMe]I, which was readily deprotonated to afford the neutral compound [{κ(3) -N-C(3-Ad-5-Mepz)3 }MgMe]. The related magnesium butyl compound [{κ(3) -N-C(3-Ad-5-Mepz)3 }MgBu] was prepared from the reaction of 1 and MgBu2 . Treating this with LiAlH4 or LiAlD4 led to rare examples of terminal magnesium hydride/deuteride complexes, [{κ(3) -N-C(3-Ad-5-Mepz)3 }MgH/D]. All neutral magnesium alkyl and hydride compounds were crystallographically authenticated. Reaction of [{κ(3) κN-C(3-Ad-5-Mepz)3 }Li(thf)] with [YbI2 (thf)2 ] yielded the first structurally characterized f-block tris(pyrazolyl)methanide complex, [{κ(3) -N-C(3-Ad-5-Mepz)3 }YbI(thf)]. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. Precursor life science experiments and closed life support systems on the Moon (United States)

    Rodriguez, A.; Paille, C.; Rebeyre, P.; Lamaze, B.; Lobo, M.; Lasseur, C.

    Nowadays the Moon is not only a scientific exploration target but also potentially also a launch pad for deeper space exploration. Establishing an extended human presence on the Moon could reduce the cost of further space exploration, and gather the technical and scientific experience that would make possible the next steps of space exploration, namely manned-missions to Mars. To enable the establishment of such a Moon base, a reliable and regenerative life support system (LSS) is required: without any recycling of metabolic consumables (oxygen, water and food), a 6-person crew during the course of one year would require a supply of 12t from Earth (not including water for hygiene purposes), with a prohibitive associated cost! The recycling of consumables is therefore mandatory for a combination of economic, logistical and also safety reasons. Currently the main regenerative technologies used, namely water recycling in the ISS, are physical-chemical but they do not solve the issue of food production. In the European Space Agency, for the last 15 years, studies are being performed on several life support topics, namely in air revitalisation, food, water and waste management, contaminants, monitoring and control. Ground demonstration, namely the MELiSSA Pilot Plant and Concordia Station, and simulation studies demonstrated the studies feasibility and the recycling levels are promising. To be able to build LSS in a Moon base, the temperature amplitude, the dust and its 14-day night, which limits solar power supply, should be regarded. To reduce these technical difficulties, a landing site should be carefully chosen. Considering the requirements of a mission to the Moon and within the Aurora programme phase I, a preliminary configuration for a regenerative LSS can be proposed as an experiment for a precursor mission to the Moon. An overview of the necessary LSS to a Moon base will be presented, identifying Moon?s specific requirements and showing preliminary

  10. Diversity of Flea (Siphonaptera) Parasites on Red Foxes (Vulpes vulpes) in Romania. (United States)

    Foley, P; Foley, J; Sándor, A D; Ionica, A M; Matei, I A; D'Amico, G; Gherman, C M; Dom A, C; Mihalca, A D


    Red foxes (Vulpes vulpes (L.)) are widespread across Europe, tolerant of synanthropic ecosystems, and susceptible to diseases potentially shared with humans and other animals. We describe flea fauna on red foxes in Romania, a large, ecologically diverse country, in part because fleas may serve as an indicator of the risk of spillover of vector-borne disease. We found 912 individual fleas of seven species on the 305 foxes assessed, for an infestation prevalence of 49.5%. Mean flea load per fox was 5.8 (range 0-44 fleas), and flea detections were most abundant in fall and early spring. Fleas included generalists (Ctenocephalides canis (Curtis), 32.6% of all fleas), Ct. felis (Bouché, 0.1%), and Pulex irritans L. (29.9%), the fox specialist Chaetopsylla globiceps (Taschenberg, 32.5%), mesocarnivore fleas Paraceras melis Walker (3.2%) and Ch. trichosa Kohaut (1.5%), and the small mammal flea Ctenophthalmus assimilis (Taschenberg, 0.1%), which is rarely or never reported from carnivores. There were significantly more female than male Ch. globiceps, Ct. canis, and Pu. irritans, and these three species were the most broadly distributed geographically. Diversity indices suggested reduced diversity in mountainous areas above 700 m. When compared to other flea studies on foxes in Europe, Romania had flea diversity near the median of reports, which was unexpected given Romania's high ecological diversity. Notably absent prey specialists, compared to other studies, include Archaeopsylla erinacei (Bouché) and Spilopsyllus cuniculi (Dale). Further studies of possible disease agents in fox fleas could help elucidate possible risks of vector-borne disease in foxes, domestic animals, and humans as well. © The Authors 2017. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email:


    Directory of Open Access Journals (Sweden)

    Bonaci Carmen Giorgiana


    Full Text Available Our paper contributes to the literature on international accounting by focusing on the standard setting process. As documented by research literature, accounting regulation can enhance corporate governance (Melis and Carta, 2010, corporate reporting being expected to reduce information asymmetry. Based on accounting research and trade literature we first synthesize recent evolutions in the international accounting arena. We therefore position our study within current realities significantly marked by uncertainty in relation to the world wide globalization process. The objective of our paper is to perform an analysis that would help assess further developments of the convergence project. This is done by looking at the current status of the projects being developed under the IASB –FASB collaboration, as well as by developing a comparison between IFRS and US GAAP. The employed research methodology relies on analyzing data provided through the IASB and the FASB’s websites, as well as other official documents being issued by the two Boards. The assessment of the projects was done by reviewing exposure documents and monitoring the Boards’ deliberations, while the developed comparison requires accounting regulations content analysis. Concluding upon the Boards’ ongoing projects, we might identify areas in which convergence seems to be quite close (such as revenue recognition and leasing, but also areas in which convergence becomes even more challenging (such as financial instruments or the particular case of offsetting. Similar to other studies being developed within accounting research and trade literature (SEC 2011: 8 we may conclude that, generally, US GAAP present more detailed, specific requirements than IFRS.

  12. The central globular domain of the nucleocapsid protein of human immunodeficiency virus type 1 is critical for virion structure and infectivity. (United States)

    Ottmann, M; Gabus, C; Darlix, J L


    The nucleocapsid protein NCp7 of human immunodeficiency virus type 1 (HIV-1) is a 72-amino-acid peptide containing two CCHC-type zinc fingers linked by a short basic sequence, 29RAPRKKG35, which is conserved in HIV-1 and simian immunodeficiency virus. The complete three-dimensional structure of NCp7 has been determined by 1H-nuclear magnetic resonance spectroscopy (N. Morellet, H. de Rocquigny, Y. Mely, N. Jullian, H. Demene, M. Ottmann, D. Gerard, J. L. Darlix, M. C. Fournié-Zaluski, and B. P. Roques, J. Mol. Biol. 235:287-301, 1994) and revealed a central globular domain where the two zinc fingers are brought in close proximity by the RAPRKKG linker. To examine the role of this globular structure and more precisely of the RAPRKKG linker in virion structure and infectivity, we generated HIV-1 DNA mutants in the RAPRKK sequence of NCp7 and analyzed the mutant virions produced by transfected cells. Mutations that probably alter the structure of NCp7 structure led to the formation of very poorly infectious virus (A30P) or noninfectious virus (P31L and R32G). In addition, the P31L mutant did not contain detectable amounts of reverse transcriptase and had an immature core morphology, as determined by electron microscopy. On the other hand, mutations changing the basic nature of NCp7 had poor effect. R29S had a wild-type phenotype, and the replacement of 32RKK34 by SSS (S3 mutant) resulted in a decrease by no more than 100-fold of the virus titer. These results clearly show that the RAPRKKG linker contains residues that are critical for virion structure and infectivity.

  13. The involvement of carbohydrate reserves in hydrogen photoproduction by the green alga Chlamydomonas reinhardtii

    International Nuclear Information System (INIS)

    Chochois, V.


    The unicellular green alga Chlamydomonas reinhardtii is able to produce hydrogen, using water as an electron donor, and sunlight as an energy source. Although this property offers interesting biotechnological perspectives, a major limitation is related to the sensitivity of hydrogenase to oxygen which is produced by photosynthesis. It had been previously shown that in conditions of sulfur deprivation, C. reinhardtii is able to produce hydrogen during several days (Melis et an. 2000). During this process, two pathways, one direct depending on photosystem II (PSII) activity and the other involving only the PSI, are involved, starch reserves being supposed to play a role in both of these pathways. The purpose of this phD thesis was to elucidate the mechanisms linking starch catabolism to the hydrogen photoproduction process. Firstly, the analysis of mutants affected in starch biosynthesis (sta6 and sta7) showed that if starch reserves are essential to the functioning of the indirect pathway, they are not involved in the direct one. Secondly, in order to identify metabolic steps and regulatory processes involved in starch breakdown, we developed a genetic approach based on the search of mutants affected in starch reserves mobilization. Eight mutant (std1 to std8) diversely affected in their ability to degrade starch after an accumulation phase have been isolated from an insertional mutant library of 15,000 clones. One of these mutants, std1, is affected in a kinase related to the DYRK family (dual-specificity tyrosine regulated serine threonine kinase). Although the targets of this putative kinase remain to be identified, the analysis of the granule bound proteome displayed profound alterations in the expression profile of starch phosphorylases, potentially involved in starch breakdown. STD1 represents the first starch catabolism regulator identified to date in plants. (author)


    Directory of Open Access Journals (Sweden)

    Slavko Obadov


    Full Text Available Re sults in sports with polystruc tu ral acyclic mo ve ments, in which tec hni cal charac te ri stics are pre do mi nant, are in clo se re la ti on ship with se lec tion of a pro per tec hnique af fec ting to a gre at ex tent the ac hi e ve ment of the de si red re sults. Ju do sport with abo ut 100 ba sic tec hni qu es, which can be ap plied in sports fi ght in se ve ral ways, are go ver ned by morp ho lo gi cal cha rac te ri stics of the fi g hters, the ir motor abi li ti es, as well as by the ir cog ni ti ve and con na ti ve cha rac te ri stics. Du ring the pro cess of le ar ning, espe ci ally advan ce ment in the de si red tec hni que, met hod of advan ce ment in this tec hni que is ex tre mely im por tant. One of the most ef fi ci ent ju do tec hni qu es in hand thro wing is Tai Otos hi. Ba sed on the mo ni to ring of ju do com pe ti tors in the re gion of Ser bia and wi der, it may be conclu ded that this tec hni que has rat her low usa ge. It must al so be no ted that fi g hters most of ten apply this tec hni que in cor rectly which af fects the ef fi ci ency of the per for man ce it self.

  15. Soybean cultivation for Bioregenerative Life Support Systems (BLSSs): The effect of hydroponic system and nitrogen source (United States)

    Paradiso, Roberta; Buonomo, Roberta; Dixon, Mike A.; Barbieri, Giancarlo; De Pascale, Stefania


    Soybean [Glycine max (L.) Merr.] is one of the plant species selected within the European Space Agency (ESA) Micro-Ecological Life Support System Alternative (MELiSSA) project for hydroponic cultivation in Biological Life Support Systems (BLSSs), because of the high nutritional value of seeds. Root symbiosis of soybean with Bradirhizobium japonicum contributes to plant nutrition in soil, providing ammonium through the bacterial fixation of atmospheric nitrogen. The aim of this study was to evaluate the effects of two hydroponic systems, Nutrient Film Technique (NFT) and cultivation on rockwool, and two nitrogen sources in the nutrient solution, nitrate (as Ca(NO3)2 and KNO3) and urea (CO(NH2)2), on root symbiosis, plant growth and seeds production of soybean. Plants of cultivar 'OT8914', inoculated with B. japonicum strain BUS-2, were grown in a growth chamber, under controlled environmental conditions. Cultivation on rockwool positively influenced root nodulation and plant growth and yield, without affecting the proximate composition of seeds, compared to NFT. Urea as the sole source of N drastically reduced the seed production and the harvest index of soybean plants, presumably because of ammonium toxicity, even though it enhanced root nodulation and increased the N content of seeds. In the view of large-scale cultivation for space colony on planetary surfaces, the possibility to use porous media, prepared using in situ resources, should be investigated. Urea can be included in the nutrient formulation for soybean in order to promote bacterial activity, however a proper ammonium/nitrate ratio should be maintained.

  16. New genome sequence data and molecular tools promote the use of photosynthetic and edible cyanobacteria in bioregenerative systems to support human space exploration. (United States)

    Leys, Natalie; Morin, Nicolas; Janssen, Paul; Mergeay, Max

    Cyanobacteria are daily used as nutritional supplements (e.g. Spirulina) and are considered for promising applications beyond Earth, in space, where they can play a crucial role in closed miniaturised biological waste recycling systems that are currently developed to support future long-term space missions. Cyanobacteria can be cultured with artificial light in controllable photobioreactors, and used for the efficient removal of CO2 from and production of O2 in the at-mosphere of the confined spacecraft, for removal of nitrate from waste water that is recycled to potable water, and as complementary food source. In this context, the filamentous cyanobac-terium Arthrospira sp. PCC 8005 was selected as part of the bio-regenerative life-support system MELiSSA from the European Space Agency. For bioprocess control and optimisation, the access to its genetic information and the development of molecular tools is crucial. Here we report on our efforts to determine the full genome of the cyanobacterium Arthrospira sp. PCC 8005. The obtained sequence data were analysed in detail to gain a better insight in the photosynthetic, nutritive, or potential toxic potential of this strain. In addition, the sensitivity of PCC 8005 to ionizing radiation was investigated because prolonged exposure of PCC 8005 to cosmic radiation in space might have a deleterious effect on its metabolism and oxygenic properties. To our knowledge, of the 6 different research groups across the globe trying to sequence Arthrospira strains, none of them, including us, were yet able to obtain a complete genome sequence. For Arthrospira sp. strain PCC 8005, we obtained 119 contigs (assembled in 16 scaffolds), representing 6,3 Mb, with 5,856 predicted protein-coding sequences (CDSs) and 176 genes encoding RNA. The PCC 8005 genome displays an unusual high number of large repeated sequences, covering around 8% of the genome, which likely hampered the sequenc-ing. The PCC 8005 genome is also ridden by mobile

  17. Resim-İş Eğitimi Anabilim Dalı Atölye (Grafik Dersinde Yazı ve Tipografi Öğretimi Uygulamaları / Practices of Writing and Typography Teaching at the Department of Fine Arts Education Workshop (Graphic Design Course

    Directory of Open Access Journals (Sweden)

    Şirin BENUĞUR


    Full Text Available Bu araştırmanın amacı, Eğitim Fakültesi Güzel Sanatlar Eğitimi Bölümü Resim İş Eğitimi ABD Anasanat Atölye (Grafik ve/veya Seçmeli Sanat Atölye (Grafik derslerinde tipografi eğitiminin nasıl gerçekleştirildiğini ortaya koymaktır. Araştırma tarama modelinde desenlenmiştir. Hazırlanan anket, 2007-2008 öğretim yılının bahar döneminde 24 üniversitede bu dersi veren/vermiş olan 45 öğretim elemanına uygulanmıştır. Ayrıca çalışma evreninden 7 öğretim elemanıyla yarı yapılandırılmış görüşme gerçekleştirilmiştir. Araştırma sonucunda sanat eğitimcisi yetiştirmede tipografi eğitiminin çok önemli ve gerekli olduğu, tipografi öğretimini planlarken farklı konu ve tekniklerden yararlanılarak uygulama yapılmasına, kuramsal bilgi vermeye, proje çalışmaları yaptırmaya, örneklerle konuyu açıklamaya, çesitli öğretim yöntem ve tekniklerinden yararlanmaya, tipografi öğretimini desteklemeye yönelik çeşitli etkinlikler gerçekleştirmeye önem verildiği belirlenmiştir. Tipografi öğretiminde öğrenciden, kaynak kitap ve ders saati süresinin yetersizliğinden kaynaklanan sorunlar yaşandığı belirlenmiştir. Yazı dersinin tipografi öğretimine temel oluşturacağını ifade eden öğretim elemanları, dersin içeriğinin alan uzmanları tarafından zenginleştirilmesine, ders süresinin arttırılmasına ve tipografi dersleriyle desteklenmesine yönelik önerilerde bulunmuşlardır.

  18. Preliminary results of Physiological plant growth modelling for human life support in space (United States)

    Sasidharan L, Swathy; Dussap, Claude-Gilles; Hezard, Pauline


    Human life support is fundamental and crucial in any kind of space explorations. MELiSSA project of European Space Agency aims at developing a closed, artificial ecological life support system involving human, plants and micro organisms. Consuming carbon dioxide and water from the life support system, plants grow in one of the chambers and convert it into food and oxygen along with potable water. The environmental conditions, nutrient availability and its consumption of plants should be studied and necessarily modeled to predict the amount of food, oxygen and water with respect to the environmental changes and limitations. The reliability of a completely closed system mainly depends on the control laws and strategies used. An efficient control can occur, only if the system to control is itself well known, described and ideally if the responses of the system to environmental changes are predictable. In this aspect, the general structure of plant growth model has been designed together with physiological modelling.The physiological model consists of metabolic models of leaves, stem and roots, of which concern specific metabolisms of the associated plant parts. On the basis of the carbon source transport (eg. sucrose) through stem, the metabolic models (leaf and root) can be interconnected to each other and finally coupled to obtain the entire plant model. For the first step, leaf metabolic model network was built using stoichiometric, mass and energy balanced metabolic equations under steady state approach considering all necessary plant pathways for growth and maintenance of leaves. As the experimental data for lettuce plants grown in closed and controlled environmental chambers were available, the leaf metabolic model has been established for lettuce leaves. The constructed metabolic network is analyzed using known stoichiometric metabolic technique called metabolic flux analysis (MFA). Though, the leaf metabolic model alone is not sufficient to achieve the

  19. Trimethylsilylcyclopentadienyl (cp{sup '}) uranium chemistry. Synthetic and structural studies of Cp{sup '}{sub 4}U and Cp{sup '}{sub 3}UX (X = Cl, I, Me)

    Energy Technology Data Exchange (ETDEWEB)

    Windorff, Cory J.; MacDonald, Matthew R.; Ziller, Joseph W.; Evans, William J. [Department of Chemistry, University of California, Irvine, CA (United States)


    Cp{sup '}{sub 4}U (Cp{sup '} = C{sub 5}H{sub 4}SiMe{sub 3}) was synthesized from: (a) KCp{sup '} and [Cp{sup '}{sub 3}U(THF)][BPh{sub 4}]; (b) Cp{sup '}{sub 3}U and Cp{sup '}{sub 2}Pb; and (c) [K(2.2.2-cryptand)][Cp{sup '}{sub 4}U] and AgBPh{sub 4}. The compound was identified by X-ray crystallography as a rare example of a structurally-characterized tetrakis(cyclopentadienyl)U{sup IV} complex. For comparison, the corresponding Th complex, Cp{sup '}{sub 4}Th, was isolated from the direct combination of ThBr{sub 4}(THF){sub 4} with excess KCp{sup '}. During the preparation of Cp{sup '}{sub 3}UMe, the precursor of the [Cp{sup '}{sub 3}U(THF)][BPh{sub 4}] reagent used above, it was discovered that the reaction of Cp{sup '}{sub 3}UCl and MeLi gives a mixture of Cp{sup '}{sub 3}UMe and Cp{sup '}{sub 3}UCl that can co-crystallize better than Cp{sup '}{sub 3}UMe in pure form. The Cp'{sub 3}UMe/Cp{sup '}{sub 3}UCl mixture forms single crystals suitable for X-ray crystallography and provides a new way to characterize the oil, Cp{sup '}{sub 3}UMe. Cp{sup '}{sub 3}UCl and Cp{sup '}{sub 3}UI were also crystallographically characterized for comparison with the Cp{sup '}{sub 3}UMe/Cp{sup '}{sub 3}UCl crystals. (copyright 2017 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  20. Use of oral contraceptives in the management of acne

    Directory of Open Access Journals (Sweden)

    Melis GB


    Full Text Available Gian Benedetto Melis, Marisa Orrù, Maria Francesca Marotto, Monica Pilloni, Mariagrazia Perseu, Stefano Lello, Anna Maria PaolettiClinica Ginecologica Ostetrica e di Fisiopatologia della Riproduzione Umana, Universita' di Cagliari, Azienda Ospedaliero Universitaria di Cagliari, Cagliari, ItalyAbstract: The pathogenesis of acne (the most common disorder involving the sebaceous gland originates from increased sebum production by the sebaceous gland followed by colonization of the hair follicle with Propionibacterium acnes, hyperkeratinization of the upper follicle, and release of inflammatory mediators into the skin. Androgens are the main stimulators of sebum production. Androgens originate from the gonads and adrenal glands, but can also be locally produced within the sebaceous gland from dehydroepiandrosterone sulfate. In the presence of high androgen levels, which can be either a normal pattern of adolescence or a consequence of gonadal or adrenal disease, overproduction of sebum triggers the pathogenesis of acne which, mainly in adolescent women, has deleterious psychological consequences. Estrogens exert the opposite action on sebum production, probably due to the reduction of androgen availability, a direct consequence of estrogen-related increased production of hepatic sex hormone-binding globulin (SHBG. The inhibition of the hypothalamus-pituitary axis induced by oral contraceptives is followed by reduced androgen production. Oral contraceptives containing ethinyl estradiol, which has strong estrogenic activity, amplify the hypoandrogenic effect via estrogen-related stimulation of SHBG. The hypoandrogenic effect of oral contraceptives is modulated by the progestin compound. Progestins derived from 19-nortestosterone bind androgenic receptors, whereas others exert antiandrogenic properties by antagonizing the binding of androgens to their receptors, reduce 5α-reductase, and do not bind SHBG. Through this last effect, SHBG is freely

  1. A hybridized membrane-botanical biofilter for improving air quality in occupied spaces (United States)

    Llewellyn, David; Darlington, Alan; van Ras, Niels; Kraakman, Bart; Dixon, Mike

    number of space-specific applications such as odors arising from aspects of the MELiSSA system and spacequalified small animal cages, our focus was on indoor air quality as the terrestrial application of this technology. This paper describes aspects of the development of this technology from conceptualization through laboratory trials to the design, construction and field trials of pre-market prototypes.

  2. İlköğretim Öğretmenlerinin İlköğretim Okullarında Yaşadıkları Yıldırma Durumları

    Directory of Open Access Journals (Sweden)

    Esengül ÇOMAK


    Full Text Available Bu araştırmada, ilköğretim okullarında görev yapan öğretmenlerin, maruz kaldıkları yıldırma durumları (mobbing incelenmiştir. Betimsel araştırma tekniklerine uygun olarak desenlenmiş araştırmada örneklemi, Adana ili merkez ilçelerindeki 21 ilköğretim okulunda görev yapan 381 öğretmen oluşturmuştur. Araştırmada öğretmenlerin yaşadıkları yıldırma durumları dört boyutta ele alınmıştır: Kendini gösterme ve iletişim, sosyal ilişkiler, itibara saldırı ile yaşam kalitesi ve mesleki durum. Araştırma sonucunda öğretmenlerin yaşadıkları yıldırma durumları cinsiyete ve öğretim kademesine göre anlamlı düzeyde farklılaşmamıştır. Sözleşmeli öğretmenler, kendini gösterme ve iletişim ile sosyal ilişkiler konusunda kadrolu öğretmenlerden daha fazla yıldırmaya maruz kalmaktadırlar. Sayısal branşlardaki öğretmenlerin yaşadıkları yıldırma durumları, kültür branşlarındaki öğretmenlerden fazladır. En fazla yıldırmaya maruz kalan öğretmenler 0-5 yıl kıdeme sahip olanlardır. 20-30 yaşlardaki öğretmenler, diğerlerine göre daha fazla yıldırmaya maruz kalmaktadırlar.

  3. Biological activity of Ruta chalepensis (Rutaceae and Sechium pittieri (Cucurbitaceae extracts on Hypsipyla grandella (Lepidoptera: Pyralidae larvae

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    Fernando Mancebo


    Full Text Available Biological activity of a plant extract (common rue, Ruta chalepensis and a semi purifíed fraction (from "tacaco cimarrón", Sechium pittieri on mahogany shootborer larvas (Hypsipyla grandella was studied. A randomized complete block design, with four replications, was used. H. grandella third instar larvas were exposed for 24 h to Cedrela odorata leaf discs dipped in several treatment dissolutions of each extract (0.1, 0.32, 1.0, 3.20, and 10%; afterwards, each larva was transferred to a flask containing an artificial diet and was allowed to complete its development. Variables measured included food consumption (foliar area eaten in 24 h, mortality, and developmental effects (developmental time for each larval instar and the pupa, and pupal weight. The common rue extract showed a clear antifeedant activity at a concentration as low as 0.32%, whereas the "tacaco cimarrón" fraction caused toxicity, especially at the two highest concentrations (3.20 and 10%.Se estudió la actividad biológica de un extracto de follaje de ruda (Ruta chalepensis y de una fracción semipurificada de "tacaco cimarrón" (Sechium pittieri sobre las larvas del gusano barrenador de las meliáceas (Hypsipyla grandella. Se utilizó un diseño de bloques completos al azar, con cuatro repeticiones. Durante 24 h se expusieron larvas de tercer estadio de H. grandella a discos de follaje de Cedrela odorata impregnados con cada tratamiento. Estos consistieron en disoluciones de cada extracto (0.1, 0.32, 1.0, 3.20 y 10%; posteriormente cada larva se transfirió a un frasco que contenía dieta artificial, donde se le permitió completar su desarrollo. Las variables de respuesta fueron el consumo de alimento (área foliar comida en 24 h, la mortalidad y efectos sobre el desarrollo (tiempo de desarrollo de cada estadio larval y de la pupa, y el peso de la pupa. El extracto de ruda causó fagodisuasión a una concentración de apenas 0.32%, mientras que la fracción de "tacaco cimarr

  4. Canadian advanced life support capacities and future directions (United States)

    Bamsey, M.; Graham, T.; Stasiak, M.; Berinstain, A.; Scott, A.; Vuk, T. Rondeau; Dixon, M.


    Canada began research on space-relevant biological life support systems in the early 1990s. Since that time Canadian capabilities have grown tremendously, placing Canada among the emerging leaders in biological life support systems. The rapid growth of Canadian expertise has been the result of several factors including a large and technically sophisticated greenhouse sector which successfully operates under challenging climatic conditions, well planned technology transfer strategies between the academic and industrial sectors, and a strong emphasis on international research collaborations. Recent activities such as Canada's contribution of the Higher Plant Compartment of the European Space Agency's MELiSSA Pilot Plant and the remote operation of the Arthur Clarke Mars Greenhouse in the Canadian High Arctic continue to demonstrate Canadian capabilities with direct applicability to advanced life support systems. There is also a significant latent potential within Canadian institutions and organizations with respect to directly applicable advanced life support technologies. These directly applicable research interests include such areas as horticultural management strategies (for candidate crops), growth media, food processing, water management, atmosphere management, energy management, waste management, imaging, environment sensors, thermal control, lighting systems, robotics, command and data handling, communications systems, structures, in-situ resource utilization, space analogues and mission operations. With this background and in collaboration with the Canadian aerospace industry sector, a roadmap for future life support contributions is presented here. This roadmap targets an objective of at least 50% food closure by 2050 (providing greater closure in oxygen, water recycling and carbon dioxide uptake). The Canadian advanced life support community has chosen to focus on lunar surface infrastructure and not low Earth orbit or transit systems (i.e. microgravity

  5. Selection and hydroponic growth of bread wheat cultivars for bioregenerative life support systems (United States)

    Page, V.; Feller, U.


    As part of the ESA-funded MELiSSA program, the suitability, the growth and the development of four bread wheat cultivars were investigated in hydroponic culture with the aim to incorporate such a cultivation system in an Environmental Control and Life Support System (ECLSS). Wheat plants can fulfill three major functions in space: (a) fixation of CO2 and production of O2, (b) production of grains for human nutrition and (c) production of cleaned water after condensation of the water vapor released from the plants by transpiration. Four spring wheat cultivars (Aletsch, Fiorina, Greina and CH Rubli) were grown hydroponically and compared with respect to growth and grain maturation properties. The height of the plants, the culture duration from germination to harvest, the quantity of water used, the number of fertile and non-fertile tillers as well as the quantity and quality of the grains harvested were considered. Mature grains could be harvested after around 160 days depending on the varieties. It became evident that the nutrient supply is crucial in this context and strongly affects leaf senescence and grain maturation. After a first experiment, the culture conditions were improved for the second experiment (stepwise decrease of EC after flowering, pH adjusted twice a week, less plants per m2) leading to a more favorable harvest (higher grain yield and harvest index). Considerably less green tillers without mature grains were present at harvest time in experiment 2 than in experiment 1. The harvest index for dry matter (including roots) ranged from 0.13 to 0.35 in experiment 1 and from 0.23 to 0.41 in experiment 2 with modified culture conditions. The thousand-grain weight for the four varieties ranged from 30.4 to 36.7 g in experiment 1 and from 33.2 to 39.1 g in experiment 2, while market samples were in the range of 39.4-46.9 g. Calcium levels in grains of the hydroponically grown wheat were similar to those from field-grown wheat, while potassium, magnesium

  6. Synthesis and structural characterisation of alkali metal complexes of heteroatom-stabilised 1,4- and 1,6-dicarbanions. (United States)

    Izod, Keith; Bowman, Lyndsey J; Wills, Corinne; Clegg, William; Harrington, Ross W


    A straightforward Peterson olefination reaction between either [{(Me(2)PhSi)(3)C}Li(THF)] or in situ-generated [(Me(3)Si)(2){Ph(2)P(BH(3))}CLi(THF)(n)] and paraformaldehyde gives the alkenes (Me(2)PhSi)(2)C[double bond, length as m-dash]CH(2) () and (Me(3)Si){Ph(2)P(BH(3))}C[double bond, length as m-dash]CH(2) (), respectively, in good yield. Ultrasonic treatment of with lithium in THF yields the lithium complex [{(Me(2)PhSi)(2)C(CH(2))}Li(THF)(n)](2) (), which reacts in situ with one equivalent of KOBu(t) in diethyl ether to give the potassium salt [{(Me(2)PhSi)(2)C(CH(2))}K(THF)](2) (). Similarly, ultrasonic treatment of with lithium in THF yields the lithium complex [[{Ph(2)P(BH(3))}(Me(3)Si)C(CH(2))]Li(THF)(3)](2).2THF (). The bis(phosphine-borane) [(Me(3)Si){Me(2)(H(3)B)P}CH(Me(2)Si)(CH(2))](2) () may be prepared by the reaction of [Me(2)P(BH(3))CH(SiMe(3))]Li with half an equivalent of ClSiMe(2)CH(2)CH(2)SiMe(2)Cl in refluxing THF. Metalation of with two equivalents of MeLi in refluxing THF yields the lithium complex [[{Me(2)P(BH(3))}(Me(3)Si)C{(SiMe(2))(CH(2))}]Li(THF)(3)](2) (), whereas metalation with two equivalents of MeK in cold diethyl ether yields the potassium complex [[{Me(2)P(BH(3))}(Me(3)Si)C{(SiMe(2))(CH(2))}](2)K(2)(THF)(4)](infinity) () after recrystallisation. X-Ray crystallography shows that, whereas the lithium complex crystallises as a discrete molecular species, the potassium complexes and crystallise as sheet and chain polymers, respectively.

  7. Selection and hydroponic growth of potato cultivars for bioregenerative life support systems (United States)

    Molders, K.; Quinet, M.; Decat, J.; Secco, B.; Dulière, E.; Pieters, S.; van der Kooij, T.; Lutts, S.; Van Der Straeten, D.


    As part of the ESA-funded MELiSSA program, Ghent University and the Université catholique de Louvain investigated the suitability, growth and development of four potato cultivars in hydroponic culture under controlled conditions with the aim to incorporate such cultivation system in an Environmental Control and Life Support System (ECLSS). Potato plants can fulfill three major functions in an ECLSS in space missions: (a) fixation of CO2 and production of O2, (b) production of tubers for human nutrition and (c) production of clean water after condensation of the water vapor released from the plants by transpiration. Four cultivars (Annabelle, Bintje, Desiree and Innovator) were selected and grown hydroponically in nutrient film technique (NFT) gullies in a growth chamber under controlled conditions. The plant growth parameters, tuber harvest parameters and results of tuber nutritional analysis of the four cultivars were compared. The four potato cultivars grew well and all produced tubers. The growth period lasted 127 days for all cultivars except for Desiree which needed 145 days. Annabelle (1.45 kg/m2) and Bintje (1.355 kg/m2) were the best performing of the four cultivars. They also produced two times more tubers than Desiree and Innovator. Innovator produced the biggest tubers (20.95 g/tuber) and Desiree the smallest (7.67 g/tuber). The size of Annabelle and Bintje potatoes were intermediate. Bintje plants produced the highest total biomass in term of DW. The highest non-edible biomass was produced by Desiree, which showed both the highest shoot and root DW. The manual length and width measurements were also used to predict the total tuber mass. The energy values of the tubers remained in the range of the 2010 USDA and Souci-Fachmann-Kraut food composition databases. The amount of Ca determined was slightly reduced compared to the USDA value, but close to the Souci-Fachmann-Kraut value. The concentration of Cu, Zn and P were high compared to both databases

  8. Negatywna seksualność jako bierna postawa społeczna

    Directory of Open Access Journals (Sweden)

    Marta Płonecka


    oporu wobec władzy nad ludzką seksualnością. Opisuję zjawisko biooporu i uwalniania cielesności na przykładzie pracy Krzysztofa Pacewicza o teoriach Michela Foucaulta i Giorgio Agambena. Analizuję kondycję edukacji seksualnej i ruchów antydyskryminacyjnych w Polsce w czasie teraźniejszym. Moja praca ma pokazać, że sekspozytywna postawa życiowa, czyli akceptacja siebie i innych oraz tworzenie bezprzemocowej przestrzeni umożliwia powszechną samoakceptację i samorozwój. Jest jednocześnie aktywną postawą społeczną, ponieważ wymaga zaangażowania intelektualnego i politycznego we wpływaniu na zastaną rzeczywistość. Uważam, że pozytywna seksualność, wspierana pozytywną edukacją seksualną i zaangażowaniem społecznym, to bardzo istotny element oporu wobec relacji władzy.

  9. Segnalazioni/Informes/Rapports/Reports

    Directory of Open Access Journals (Sweden)

    Emanuele Monegato


    , Barcelona, Anagrama, 2012, 434 pp. ISBN 978-84-339-2597-8 José “Cheche” Campos Dávila, Ajum decía mi abuela , Lima, Editorial San Marcos, 2011, 199 pp. ISBN 978-612-302-676-9 Joseph Gelfer (ed., 2012 Decoding the Countercultural Apocalypse, Oakville and Sheffield, Equinox Publishing Ltd, 2011, 203 pp ISBN 978-1-84553-639-8 Juan Pablo Sutherland, Cielo dandi. Escrituras y poéticas de estilo en América latina, Buenos Aires, Eterna Cadencia, 2011, 284 pp. ISBN 978-987-1673-46-9 Luigi Cimmino, Daniele Dottorini, Giorgio Pangaro, Dal cuore di tenebra all'Apocalisse. Francis Ford Coppola legge Joseph Conrad, Soveria Mannelli, Rubbettino Editore, 2011, 205 pp. ISBN 978-884-982-907-5 Mariacristina Cavecchi, Cerchi e cicli: sulle forme della memoria in Ulisse, Piccola Biblioteca Joyciana, Roma, Bulzoni, 2012, 96 pp. ISBN 978-88-7870-723-8 Mauro Giori (ed., Poetica e prassi della trasgressione in Luchino Visconti. 1935-1962 , Milano, Lampi di stampa, 2011, 346 pp. ISBN 978-88-488-1277-1 Michela Bassanelli e Gennaro Postiglione (eds., The Atlantikwall As Military Archeological Landscape / L’Atlantikwall come paesaggio di archeologia militare , Siracusa, LetteraVentidue, 2011, 207 pp. ISBN 978-88-6242-041-9 Neil Campbell e Alasdair Kean (eds., American Cultural Studies. An Introduction to American Culture , London, Routledge, 2011, 376 pp. ISBN 978-0-415-59871-2 Silvia Antosa (ed., Queer Crossings. Theories, Bodies, Texts , Milano Mimesis, 2012, 195 pp. ISBN 978-885-750-939-6 Silvia Antosa, Crossing Boundaries: Bodily Paradigms in Jeanette Winterson's Fiction . 1985-2000 , Roma, Aracne, 2008, 224 pp. ISBN 978-885-481-682-4 Silvia Gianni, Tendenze della critica letteraria e narrativa centroamericana degli ultimi anni , Roma, Aracne editrice, 2011, 361 pp. ISBN 978-88-548-4027-0 Silvia Ross, Tuscan Spaces. Literary Contstructions of Place, Toronto/Buffalo/London, University of Toronto Press, 2010, 224 pp. ISBN 978-1-4426-3998-0 Valentina Agostinis, Londra chiama. Otto

  10. Selected Abstracts of the 10th International Workshop on Neonatology; Cagliari (Italy; October 22-25, 2014

    Directory of Open Access Journals (Sweden)

    --- Various Authors


    (Italy ABS 9. Traffiking of thymosin beta-4 in the cellular compartments of HepG2 cells at different conditions • M. Piras, M. Piludu, G. Pichiri, P. Coni, T. Cabras, R. Ambu, M. Castagnola; Cagliari and Rome (Italy ABS 10. Thyroid carcinoma in sardinian children and adolescents is often associated with autoimmune thyroiditis • P. Coni, E. Tamponi, A. Lampis, G. Pinna, A.M. Nurchi, S. Farci, M.L. Lai; Cagliari (Italy ABS 11. Prolonging nephrogenesis in preterm infants: a new approach for the prevention of renal disease in adulthood? • A. Sanna, C. Gerosa, D. Fanni, P. Van Eyken, M. Castagnola, R. Ambu; Cagliari, Rome (Italy and Leuven (Belgium ABS 12. Human adrenal gland development: morphogenesis and molecular mechanisms • E. Obinu, V. Fanos, A. Dessì, R. Ambu; Cagliari (Italy ABS 13. Biometrics application for newborns safe identification in Neonatal Intensive Care Units • A. Casanova, S. Barra, M. De Marsico, D. Riccio, L. Barberini, M. Puddu, V. Fanos; Cagliari, Rome and Naples (Italy ABS 14. Metabolomics in neonatal hypoxic-ischemic encephalopathy (HIE: a proposal for a european multicenter study • P. Gancia, G. Pomero, A. Delogu, C. Dalmazzo, G. Palmas, V. Fanos; Cuneo and Cagliari (Italy ABS 15. Longitudinal evaluation of myocardial function in infants with Hypoxic-Ischemic Encephalopathy (HIE: preliminary data • F. Vitali, S. Galletti, A. Aceti, L. Ridolfi, G. Aquilano, M. Fabi, G. Faldella; Bologna (Italy ABS 16. Changes in podocyte number during intrauterine development • M. Desogus, A. Crobe, A. Sanna, C. Gerosa, C. Fanni, C. Loddo, M. Puddu, G. Ottonello, D. Fanni; Cagliari (Italy ABS 17. Efficacy of recombinant human erythropoietin in anemic pregnant women with heterozygous beta-thalassemia • S. Angioni, V. Mais, G.B. Melis; Cagliari (Italy ABS 18. WT1 expression in ontogenesis of human fetus • R. Ambu, L. Vinci, C. Gerosa, D. Fanni, E. Obinu, A. Faa, V. Fanos; Cagliari (Italy ABS 19. Brain hypothermia in perinatal arterial ischemic

  11. Hydroponic cultivation of soybean for Bioregenerative Life Support Systems (BLSSs) (United States)

    De Pascale, Stefania; De Micco, Veronica; Aronne, Giovanna; Paradiso, Roberta

    For long time our research group has been involved in experiments aiming to evaluate the possibility to cultivate plants in Space to regenerate resources and produce food. Apart from investigating the response of specific growth processes (at morpho-functional levels) to space factors (namely microgravity and ionising radiation), wide attention has been dedicated to agro-technologies applied to ecologically closed systems. Based on technical and human dietary requirements, soybean [Glycine max (L.) Merr.] is studied as one of the candidate species for hydroponic (soilless) cultivation in the research program MELiSSA (Micro-Ecological Life Support System Alternative) of the European Space Agency (ESA). Soybean seeds show high nutritional value, due to the relevant content of protein, lipids, dietary fiber and biologically active substances such as isoflavones. They can produce fresh sprouts or be transformed in several edible products (soymilk and okara or soy pulp). Soybean is traditionally grown in open field where specific interactions with soil microrganisms occur. Most available information on plant growth, seed productivity and nutrient composition relate to cultivated varieties (cultivars) selected for soil cultivation. However, in a space outpost, plant cultivation would rely on soilless systems. Given that plant growth, seed yield and quality strictly depend on the environmental conditions, to make successful the cultivation of soybean in space, it was necessary to screen all agronomic information according to space constraints. Indeed, selected cultivars have to comply with the space growth environment while providing a suitable nutritional quality to fulfill the astronauts needs. We proposed an objective criterion for the preliminary theoretical selection of the most suitable cultivars for seed production, which were subsequently evaluated in bench tests in hydroponics. Several Space-oriented experiments were carried out in a closed growth chamber to

  12. Matematik Dersinde İsteğe Bağlı Çevrimiçi Kısa Sınav Uygulanması Hakkında Öğrenci Görüşleri

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    Harun ÇİĞDEM


    Full Text Available Bu çalışmanın amacı öğrencilerin harmanlanmış öğretim kapsamında kullandıkları çevrimiçi quiz sistemi hakkındaki görüşlerinin ortaya konmasıdır. Harmanlanmış öğretim, yüz yüze öğretim ile web tabanlı öğrenme yönetim sisteminin birlikte kullanılmasıyla oluşturulmuştur. Betimsel yöntem desenindeki çalışma bir meslek yüksekokulunda Matematik-I dersini alan 204 öğrenci üzerinde gerçekleştirilmiştir. Dersler sınıf ortamında yürütülmüş ve intranet üzerinden öğrencilere powerpoint (ppt sunuları, ders notları ve quizler sunulmuştur. Çevrimiçi quizler ile ünite bazlı toplam 126 maddelik çoktan seçmeli test maddesi havuzundan öğrencilerin yararlanmaları sağlanmıştır. Dönem sonunda öğrencilerin çevrimiçi quizler hakkındaki görüşlerini belirlemek amacıyla Çevrimiçi Quiz Değerlendirme Formu kullanılmıştır. Hazırlanan form, 103 öğrenci tarafından cevaplanmıştır. Verilerin analizinde frekans, ortalama ve t testi kullanılmıştır. Öğrencilerin genel olarak çevrimiçi quiz konusunda kararsız kaldıkları belirlenmiştir. Bilgisayar sahibi olan öğrencilerin bilgisayar sahibi olmayanlara göre, evinde internet bağlantısı olan öğrencilerin evinde internet bağlantısı olmayan öğrencilere göre ve daha önce web tabanlı sınav deneyimi olan öğrencilerin, web tabanlı sınav konusunda herhangi bir deneyimi olmayan öğrencilere göre çevrimiçi quizler konusunda daha olumlu oldukları bulunmuştur. Çevrimiçi quiz uygulamasının soru bankasının oluşturulmasının özellikle Matematik dersi için oldukça zaman alıcı olduğu belirlenmiştir. Uygulamanın en önemli avantajları öğrenci quizlerini okumak için gereken zamanın azalması ve kaynakların etkin kullanılmasıdır.

  13. Agriculture for Space: People and Places Paving the Way

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    Wheeler Raymond M.


    Full Text Available Agricultural systems for space have been discussed since the works of Tsiolkovsky in the early 20th century. Central to the concept is the use of photosynthetic organisms and light to generate oxygen and food. Research in the area started in 1950s and 60s through the works of Jack Myers and others, who studied algae for O2 production and CO2 removal for the US Air Force and the National Aeronautics and Space Administration (NASA. Studies on algal production and controlled environment agriculture were also carried out by Russian researchers in Krasnoyarsk, Siberia beginning in 1960s including tests with human crews whose air, water, and much of their food were provided by wheat and other crops. NASA initiated its Controlled Ecological Life Support Systems (CELSS Program ca. 1980 with testing focused on controlled environment production of wheat, soybean, potato, lettuce, and sweetpotato. Findings from these studies were then used to conduct tests in a 20 m2, atmospherically closed chamber located at Kennedy Space Center. Related tests with humans and crops were conducted at NASA’s Johnson Space Center in the 1990s. About this same time, Japanese researchers developed a Controlled Ecological Experiment Facility (CEEF in Aomori Prefecture to conduct closed system studies with plants, humans, animals, and waste recycling systems. CEEF had 150 m2 of plant growth area, which provided a near-complete diet along with air and water regeneration for two humans and two goats. The European Space Agency MELiSSA Project began in the late 1980s and pursued ecological approaches for providing gas, water and materials recycling for space life support, and later expanded to include plant testing. A Canadian research team at the University of Guelph developed a research facility ca. 1994 for space crop research. The Canadian team eventually developed sophisticated canopy-scale hypobaric plant production chambers ca. 2000 for testing crops for space, and have

  14. Greenhouse Module for Space System: A Lunar Greenhouse Design

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    Zeidler Conrad


    Full Text Available In the next 10 to 20 years humankind will return to the Moon and/or travel to Mars. It is likely that astronauts will eventually build permanent settlements there, as a base for long-term crew tended research tasks. It is obvious that the crew of such settlements will need food to survive. With current mission architectures the provision of food for longduration missions away from Earth requires a significant number of resupply flights. Furthermore, it would be infeasible to provide the crew with continuous access to fresh produce, specifically crops with high water content such as tomatoes and peppers, on account of their limited shelf life. A greenhouse as an integrated part of a planetary surface base would be one solution to solve this challenge for long-duration missions. Astronauts could grow their own fresh fruit and vegetables in-situ to be more independent from supply from Earth. This paper presents the results of the design project for such a greenhouse, which was carried out by DLR and its partners within the framework of the Micro-Ecological Life Support System Alternative (MELiSSA program. The consortium performed an extensive system analysis followed by a definition of system and subsystem requirements for greenhouse modules. Over 270 requirements were defined in this process. Afterwards the consortium performed an in-depth analysis of illumination strategies, potential growth accommodations and shapes for the external structure. Five different options for the outer shape were investigated, each of them with a set of possible internal configurations. Using the Analytical Hierarchy Process, the different concept options were evaluated and ranked against each other. The design option with the highest ranking was an inflatable outer structure with a rigid inner core, in which the subsystems are mounted. The inflatable shell is wrapped around the core during launch and transit to the lunar surface. The paper provides an overview of the

  15. Can nitrification bring us to Mars? The role of microbial interactions on nitrogen recovery in life support systems (United States)

    Christiaens, Marlies E. R.; Lasseur, Christophe; Clauwaert, Peter; Boon, Nico; Ilgrande, Chiara; Vlaeminck, Siegfried


    Human habitation in space requires artificial environment recirculating fundamental elements to enable the highest degree of autonomy . The European Space Agency, supported by a large consortoium of European organisationsdevelop the Micro-Ecological Life Support System (MELiSSA) to transform the mission wastes waste (a.o. organic fibers, CO2, and urine) into water, oxygen, and food (Lasseur et al., 2010). Among these wastes, astronauts' urine has a high potential to provide nitrogen as a fertilizer for food production. As higher plant growth in space is typically proposed to be performed in hydroponics, liquid fertilizer containing nitrates is preferred. An Additional Unit for Water Treatment is developed for urine nitrification by means of a synthetic microbial community. The key players in this consortium are ureolytic bacteria to hydrolyse the main nitrogen source in urine, urea, to ammonium and carbon dioxide as well as oxidation of organic compounds present in urine, ammonium oxidizing bacteria (AOB) to convert ammonium to nitrite (nitritation), and the nitrate oxidizing bacteria (NOB) to produce nitrate (nitratation). Pure AOB strains Nitrosomonas ureae Nm10 and Nitrosomonas europaea ATCC 19718, pure NOB strains Nitrobacter winogradskyi Nb-255 and Nitrobacter vulgaris Z, and interactions within synthetic consortia of one AOB and one NOB or all together were tested. As the initial salinity of fresh urine can be as high as 30 mS/cm, the functionality of selected pure strains and synthetic consortia was evaluated by means of the nitritation and nitratation activity at varying NaCl salinities (5, 10, and 30 mS/cm). The nitritation activity of pure AOB strains was compared with the synthetic consortia. Both N. ureae and Ns. europaea benefit from the presence of Nb. winogradskyi as the ammonium oxidation rates of 1.7 ± 0.7 and 6.4 ± 0.6 mg N/L.d at 5 mS/cm, respectively, doubled. These results are in line with the findings of Perez et al (2015) observing a lower

  16. Satisfacción Laboral en Profesionales de Enfermería

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    Sonia Solano Aguilar


    Full Text Available Introducción: El objetivo principal de la investigación fue describir el grado de satisfacción laboral de las Enfermeras de Clínicas y Hospitales de Bucaramanga y área Metropolitana, para ello se identificaroncaracterísticas sociodemográficas, y características laborales del personal de enfermería. Materiales y Métodos : Se trato de un estudio descriptivo multicéntrico cuya muestra la conformaron 218 enfermeras que laboran en el sector público y privado de las Clínicas y Hospitales de Bucaramanga y su área Metropolitana. Se aplicó el cuestionario de satisfacción laboral S10/12 de J.L Meliá y J.M.Peiro (1998 modificado para incluir algunos aspectos descriptivos y factores intrínsecos de la teoría de Herzberg. Resultados: En cuanto al nivel educativo un gran porcentaje el 47.2% no ha realizado ningún tipo de estudio complementario al de su pregrado, el 25.7% ha realizado alguna especialización y el 24.8% diplomado; además solo el 1.8% ha realizado maestría y el 0.5% tiene doctorado. En el 67.9% la categoría laboral es general y el 27.5% es especialista. En cuanto a la jerarquía el 88.1% laboran como enfermeras de servicio y el 0.9% ejercen labores de supervisión. Los resultados también demuestran que los factores de ambiente y supervisión están dentro de una media del 5.2 y una desviación estándar de 1.3 lo que equivale a decir que las enfermeras están satisfechas; por otro lado el factor que genera mayor inconformidad es el de las prestaciones sociales con una media de 4.7 y una desviación estándar de 1.6. Discusión y Conclusiones: Los resultados del estudio en su mayoría de ítem demuestran que las personas están satisfechas, sin embargo a pesar de esto llama la atención que un porcentaje tan alto desee trabajar fuera del país. (Rev Cuid 2010;1(1:53-62.Palabras clave: satisfacción en el trabajo, personal de enfermería, motivación, condiciones de trabajo

  17. Distribución espacio-temporal de hormigas en un gradiente de luz, dentro de un sistema agroforestal de café, en Turrialba, Costa Rica

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    Edgar H Varón


    Full Text Available En los sistemas agroforestales de café (Coffea arabica L. de Mesoamérica es frecuente la presencia de árboles de sombra. Estos sistemas pueden albergar una rica entomofauna, incluyendo hormigas, la cuales podrían depredar a plagas claves en dichos sistemas. Sin embargo, se desconoce el papel de la sombra sobre la distribución y abundancia de dichas hormigas, lo cual podría sugerir pautas para manipular ciertas condiciones de su hábitat y lograr su conservación e incremento. Por tanto, se estudió el efecto de la sombra sobre la distribución espacial y temporal de tres especies de hormigas (Solenopsis geminata, Pheidole radoszkowskii y Crematogaster curvispinosa que pueden depredar a la broca del café, Hypothenemus hampei (Coleoptera: Scolytidae y al barrenador de las meliáceas, Hypsipyla grandella. Para ello se evaluó su abundancia a través de un gradiente de sol-sombra en un cafetal con cuatro parcelas alternas (desde pleno sol hasta sombra total, en Turrialba, Costa Rica. En la comunidad estudiada se recolectaron 28 especies de hormigas, de las cuales S. geminata fue la dominante (79 % del total de individuos, seguida por P. radoszkowskii (16 %. S. geminata y C. curvispinosa prefirieron las áreas soleadas, mientras que P. radoszkowskii no mostró una preferencia definida. Asimismo, en cuanto a su ubicación, S. geminata predominó en el suelo, mientras que P. radoszkowskii y C. curvispinosa lo hicieron en los arbustos de café.Temporal and spatial distribution of ants in a light gradient, in a coffee agroforestry system, Turrialba, Costa Rica. Shade trees are frequently present in coffee (Coffea arabica L. agroforestry systems of Mesoamerica. These systems can harbor a rich entomofauna, including ants, which could be predators of key pests in these systems. However, the role of shade on the distribution and abundance of these ants is unknown, yet such knowledge could suggest guidelines for manipulating certain environmental

  18. 5th National Congress of the Italian Society of Physiotherapy

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    Alessandro Aina


    , Aina Alessandro P3 Hamstring injuries: clinical assessment or image evaluation? Bonfanti M., Pasquetti M. P4 Effectiveness of the physical therapy treatment on pelvic floor muscles in pelvic girdle pain. A literature review Bortolami Arianna, Pillastrini Paolo, Vanti Carla P5 Scapulo-humeral muscles electromiographic activity during the elevation movement of the upper limb in subjects with rotator cuff lesion Brioschi D, Vitali M, Pedretti A, Fraschini G, Tettamanti A P6 Mechanical low back pain: secular trend and intervention topics of randomized controlled trials Castellini G, Gianola S, Bonovas S, Banfi G, Moja L P7 Quality of reporting in rehabilitation interventions for low back pain: a review of published randomised controlled trials Greta Castellini, Silvia Gianola, Pamela Frigerio, Michela Agostini, Rosa Bolotta, Davide Corbetta, Monica Gasparini, Paolo Gozzer, Erica Guariento, Linda Li, Valentina Pecoraro, Valeria Sirtori, Andrea Turolla, Andreano A, Lorenzo Moja P8 Power analysis and sample size reporting in rehabilitation of low back pain: review of randomized controlled trials included in Cochrane systematic review Castellini G, Gianola S, Bonovas S, Moja L P9 A core outcome set for clinical trials in non-specific low back pain Alessandro Chiarotto, Caroline B. Terwee, Maarten Boers, Raymond W. Ostelo P10 Roland & Morris Disability Questionnaire and Oswestry Disability Index: which has better measurement properties? A systematic review and meta-analysis Alessandro Chiarotto, Lara J. Maxwell, Caroline B. Terwee, George A. Wells, Peter Tugwell, Raymond W. Ostelo P11 Prevalence of myofascial trigger points in spinal pain disorders: systematic review and meta-analysis Alessandro Chiarotto, Ron Clijsen, Cesar Fernandez-de-las-Penas, Marco Barbero P12 Post-surgical scar rating scales in physiotherapy: a systematic review Ciceri Matteo, Rossetti Sara, Vercelli Stefano P13 Efficacy of action observation pre-operative training in functional recovery after hip and

  19. Selected Lectures of the 13th International Workshop on Neonatology; Cagliari (Italy; October 25th-28th, 2017

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    --- Various Authors



  20. EDITORIAL: Announcing the 2007 Measurement Science and Technology Outstanding Paper Awards (United States)

    Foss, John; Dewhurst, Richard; Fujii, Kenichi; Regtien, Paul


    Nanoscale Systems Integration Group, School of Electronics and Computer Science, University of Southampton, Southampton SO17 1BJ, UK The paper [2] describes a novel impedance spectroscopic measurement method for applications in the identification of biological cells. The frequency-dependent impedance is obtained in the frequency domain by applying a fast M-sequence transform (FMT), and a fast Fourier transform (FFT) in the time domain response. Using FMT, the evaluation takes place within a short timescale of the order of milliseconds. This technique is used in a microfluidic impedance cytometer, for the analysis of single biological cells in suspension. The theory of the technique is analysed in depth. It is then applied to an experimental system that characterizes the impedance spectrum of red blood cells within the microfluidic system. Measured spectra show good agreement with simulations. The paper has a short but excellent introduction, supported by a solid reference list of about 55 papers describing related work. Most of these papers are citations from 2000 onwards. This is followed by a detailed analysis of maximum length sequences and theory used for predictions of spectra. It then continues with a useful description of a cytometer that was used to confirm theoretical predictions of spectra. Results are at an early stage. The system is still under development, since there are issues arising from the fact that the particle flows during the acquisition of data, and is not static in the electric field as assumed by the model. Nevertheless, the paper possesses good clarity of the motivation behind the work, of the measurement techniques developed and of the potential relevance to applications in the life sciences. 2007 Award Winners—Precision Measurement Ultraprecision micro-CMM using a low force 3D touch probe A Küng, F Meli and R Thalmann Swiss Federal Office of Metrology (METAS), Lindenweg 50, CH-3003 Bern-Wabern, Switzerland The paper [3] describes a new three

  1. Almanca Öğretmen Adaylarının Almanca Konuşma Becerilerine İlişkin Yeterlik Düzeylerinin İncelenmesi Examining The Level Of Proficiency In German Speaking Skills Of Preservice German Teachers

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    Bahar İŞİGÜZEL


    zeyi Belirleme Anketi” kullanılmıştır. Diller İçin Avrupa Ortak Başvuru Metninde (OBM konuşma becerisi için belirlenmiş olan dil betimleyicileri ışığında hazırlanmış olan anket 65 maddeden ve 3 düzeyden (A temel, B bağımsız, C yetkin oluşmaktadır. Anketin Cronbach Alpha güvenirlik katsayıları A düzeyi için 0.96, B düzeyi için 0.94, C düzeyi için 0.93 ve anketin tüm düzeyler için 0.88 olarak hesaplanmıştır. Almanca öğretmen adaylarının ulaştıkları konuşma becerisi yeterlik düzeyleri A (temel düzey için ileri düzey, B (bağımsız ve C (yetkin düzeyleri için orta düzey olarak belirlenmiştir. Ayrıca Almanca konuşma becerisi düzeyleri ile cinsiyet, yaş, akademik ortalama, üniversite sınavında alınan test dili ve mezun oldukları lise türü gibi bağımsız değişkenler arasında sadece üniversite sınavında yapılan test dili ile anlamlı bir fark bulunmuştur. Cinsiyet, yaş, akademik ortalama ve mezun olduğu lise türü ile Almanca konuşma becerisi düzeyleri arasında anlamlı bir fark bulunmamıştır. Bu araştırmanın sonuçları açısından Almanca öğretmen adaylarının kendilerini genel konuşma becerisi yeterlilik düzeyleri açısından A (temel için ileri, B (bağımsız ve C (yetkin düzeylerinde orta düzey yeterlikte görmüş olsalar da, konuşma becerilerini geliştirebilmek için programlarında yer alan konuşma becerisi derslerine ek olarak Almanca öğretimi konusunda alanlarıyla ilişkili konuşma becerilerini geliştirici seçmeli dersler eklenmesinde fayda vardır.

  2. Use of geostationary satellite imagery in optical and thermal bands for the estimation of soil moisture status and land evapotranspiration (United States)

    Ghilain, N.; Arboleda, A.; Gellens-Meulenberghs, F.


    satellites is the close monitoring of the diurnal variation of the land surface temperature. This feature reinforced the statistical strength of empirical methods. An empirical method linking land surface morning heating rates and the fraction of the vegetation cover, also known as a ‘Triangle method' (Gillies et al, 1997) is examined. This method is expected to provide an estimation of a root-zone soil moisture index. The sensitivity of the method to wind speed, soil type, vegetation type and climatic region is explored. Moreover, the impact of the uncertainty of LST and FVC on the resulting soil moisture estimates is assessed. A first impact study of using remotely sensed soil moisture index in the energy balance model is shown and its potential benefits for operational monitoring of evapotranspiration are outlined. References García-Haro, F.J., F. Camacho-de Coca, J. Meliá, B. Martínez (2005) Operational derivation of vegetation products in the framework of the LSA SAF project. Proceedings of the EUMETSAT Meteorological Satellite Conference Dubrovnik (Croatia) 19-23 Septembre. Gellens-Meulenberghs, F., Arboleda, A., Ghilain, N. (2007) Towards a continuous monitoring of evapotranspiration based on MSG data. Proceedings of the symposium on Remote Sensing for Environmental Monitoring and Change Detection. IAHS series. IUGG, Perugia, Italy, July 2007, 7 pp. Ghilain, N., Arboleda, A. and Gellens-Meulenberghs, F., (2008) Improvement of a surface energy balance model by the use of MSG-SEVIRI derived vegetation parameters. Proceedings of the 2008 EUMETSAT meteorological satellite data user's conference, Darmstadt, Germany, 8th-12th September, 7 pp. Gillies R.R., Carlson T.N., Cui J., Kustas W.P. and Humes K. (1997), Verification of the triangle method for obtaining surface soil water content and energy fluxes from remote measurements of Normalized Difference Vegetation Index (NDVI) and surface radiant temperature, International Journal of Remote Sensing, 18, pp. 3145

  3. The LEADER program in Hungary and in Europe A LEADER program Magyarországon és Európában

    Directory of Open Access Journals (Sweden)

    Bogár ESZTER


    átterében? Napjainkban egyre nagyobb jelentőséget kap a mezőgazdaság, a vidék fellendítése. Tanulmányom során szekunder forrásfeldolgozás alapján a LEADER program kialakulásába, az eddigi tapasztalatok bemutatása által kicsit a jelenlegi helyzetbe szeretnék betekintést nyújtani. Az Európai Unió mezőgazdasági politikája – a Közös Agrárpolitika - 1957 óta folyamatosan változik. A 90-es évektől kezdve felismerték a fenntartható helyi fejlődés jelentőségét, mely figyelembe veszi a vidéki térségek környezeti, gazdasági, szociális és kulturális elemeit is [11]. Új fejlesztési módszerek kidolgozására került sor, bevonva a helyi közösségeket is a megoldások keresésébe. Így született meg az Európai Unió LEADER programja. Az Európai Unióban a LEADER program jelenleg a harmadik generációját éli. A LEADER lényege abban rejlik, hogy alulról jövő kezdeményezéseket támogat. Ezáltal a projektek a helyi lakosok tudásán és helyismeretén alapulnak, ebből következően az ő igényeiknek és a táj adottságainak megfelelő ötletek valósulhatnak meg. A LEADER- program fontossága messze túlmutat a Strukturális Alapokból kapott részesedésén (mindössze 1%, hiszen a támogatások többszörösét kitevő fejlesztéseket eredményez, mindazonáltal közösséget formáló erő. Több szakértő állítása szerint a LEADER- program sikertörténet és a vidékfejlesztés megvalósításának legjobb módja. A LEADER tehát nem különálló program, hanem az új vidékfejlesztési politika egyik eszköze, az új vidékfejlesztési alapból támogatva járul majd hozzá a fenntartható vidékfejlesztéshez.

  4. Selected Abstracts of the 11th International Workshop on Neonatology; Cagliari (Italy; October 26-31, 2015

    Directory of Open Access Journals (Sweden)

    --- Various Authors


    . Newborn with multiple bone fractures • A.L. Costa, A.R. Moreira, P. Soares, A.Vilan, N. Alegrete, C. Martins, S. Gama Sousa, M. Rodrigues, H. Guimarães • Porto and Vila Nova de Famalicão (Portugal ABS 9. Birthweight and maternal lifestyle in overweight/obese women: a case-control study • R. Bruno, G. Pedrielli, P. Elisabetta, V. Bertarini, I. Neri, F. Facchinetti • Modena (Italy ABS 10. Special fixation for transmission electron microscopy unmasks unexpected structural details within the renal stem/progenitor cell niche • L. Denk, W.W. Minuth • Regensburg (Germany ABS 11. Drug use among newborns admitted to NICUs: a multicentre study • L. Cuzzolin, R. Agostino • Rome and Verona (Italy ABS 12. Assessment of renal function in neonatology • J.R. Delanghe • Gent (Belgium ABS 13. The parental competence in neonatology • C.M. Cacciatore, M.R. Morales, G. Perricone, C. Polizzi, G. Sulliotti, A. Rizzo, D. Albino • Palermo (Italy ABS 14. Epidemiological, clinical, and microbiological aspects in newborns with neonatal infection (sepsis and unspecified neonatal infection treated at the Department of Neonatology of the Lithuanian University of Health Sciences during 2007-2013 • R. Dzikienė, R. Tamelienė, D. Stonienė, R. Vidmantė, J. Garčinskienė • Kaunas (Lithuania ABS 15. Metabolomics in obstetrics: future perspectives • R. Mereu, A. Meloni, L. Barberini, S.F. Deiana, A. Noto, G.B. Melis • Cagliari (Italy ABS 16. Single-blind randomized controlled clinical trial to evaluate the nutritional adequacy of a novel human milk fortifier derived from donkey milk for the nutrition of newborns with birthweight < 1,500 g or gestational age < 32 weeks • C. Rossi, C. Peila, M. Raia, S. De Antoni, A. Noto, F. Cesare Marincola, S. Corbu, V. Fanos, E. Bertino, A. Coscia • Cagliari and Turin (Italy ABS 17. The stem cell niche in the developing cerebral cortex • L. Vinci, A.G. Naccarato, S. Nati, G. Senes, R. Murru, C. Gerosa, E. Obinu, V. Pibiri, M

  5. Selected Abstracts of the 20th National Congress of the Italian Society of Perinatal Medicine (Società Italiana di Medicina Perinatale, SIMP; Catania (Italy; March 22-24, 2018; Session “Perinatal Miscellanea”

    Directory of Open Access Journals (Sweden)

    --- Various Authors


    Tommaso, L. Marozio, B. Acaia, R. Vicini, A. Pizzardi, M. Spitaleri, C. Benedetto, B. Zaina, R. D’Amico, F. FacchinettiABS 8. REPLACING CONVENTIONAL G-BANDING KAR­YO­TYPING BY ARRAY CGH IN A SELECTED FE­TAL POPULATION • G. Giunta, M.G. Matarazzo, I. Calì, V. Corica, S. Caruso, M.M. Panella, A. CianciABS 9. EARLY aEEG FINDINGS IN NEWBORNS TREATED WITH THERAPEUTIC HYPOTHERMIA FOR HYPOXIC-ISCHAEMIC ENCEPHALOPA­THY PREDICTS NEURODEVELOPMENTAL OUT­­COME AT 18 MONTHS • F. Altomare, E. Bonanno, C.D. Costabile, M. Lucente, G.A. Pingitore, G. ScarpelliABS 10. PREGNANCY OUTCOME IN GESTATIONAL HYPERTENSION: A SINGLE CENTER EX­PE­RI­ENCE • M. Barba, A. Lembo, S. Fruci, G. Del Sordo, F. Felici, S. Moresi, C. Martino, A. Lanzone, S. FerrazzaniABS 11. THE ROLE OF OBESITY AND GESTATIONAL DIABETES ON PLACENTAL EFFICIENCY AND FETAL OXYGENATION • C. Bianchi, E. Taricco, G. Anelli, C. Novielli, C. Mandò, M. Cardellicchio, I. CetinABS 12. A STRANGE CASE OF BIG PERINEAL MASS • T. Izzo, S. Faiola, M. Lanna, F. Savi, A. Turri, G. Pavone, M. Pellegrino, I. Cetin, M.A. RusticoABS 13. GIANT MYOMAS AND PRETERM LABOR/PRETERM BIRTH: IS MYOMECTOMY DURING PREGNANCY AN OPTION TO PREVENT THEM? • A. Vidiri, S. Gueli Alletti, E. Perrone, S. Buongiorno, A. Lanzone, G. Scambia, A.F. CavaliereABS 14. CAFFEY DISEASE: PRENATAL IDEN­TIFICATION OF A CASE • A. Turri, M. Pellegrino, G. Pavone, T. Izzo, S. Faiola, L. Spaccini, M. Mariani, M.M. Lanna, M.A. RusticoABS 15. PSYCHOLOGICAL IMPACT OF MISCARRIAGE • G. Impera, I. Melis, M. Agus, S. AngioniABS 16. PSYCHOLOGICAL BURDEN OF ROUTINE ULTRASOUND: WOMEN’S ANXIETY ACROSS THE THREE TRIMESTERS OF PREGNANCY • C. Cortivo, C. Businelli, S. Bembich, C. Vecchiet, A. Norcio, M. Quadrifoglio, I. Fantasia, L. Lobello, T. StampalijaABS 17. IMMIGRATION AND PREGNANCY OUTCOME: DISPARITIES IN A SELECTED AFRICAN POPULATION • S. Cascella, A. Comper, R. Bortolus, C. Bovo, G. ZanconatoABS 18. PRETERM BIRTH RISK AND IMMIGRATION: THE EXPERIENCE OF AN


    Directory of Open Access Journals (Sweden)

    Ali GÖÇER


    tarama tekniği kullanılmıştır. İncelenecek Türkçe öğrenci çalışma kitaplarının toplanacağı ilköğretim okulları, amaçlı ve tabakalamalı örnekleme yolu ile belirlenmiştir. Bu çerçevede 2008-2009 öğretim yılı sonunda Kayseri’de Melikgazi, Kocasinan ve Tomarza ilçelerinin her birinden 3 olmak üzere toplam 9 ilköğretim okulu belirlenmiştir. Okulların 6. ve 7. sınıflarında öğrenim gören öğrenciler arasından seçkisiz olarak 3’er öğrenci belirlenerek 6. ve 7. sınıf düzeyinde 27’şer olmak üzere toplam 54 Türkçe Öğrenci Çalışma Kitabı (ÖÇK toplanmıştır. Her sınıf düzeyinde bir seçmeli bir de zorunlu olmak üzere 4 tema seçilmiştir. Öğrenci çalışma kitaplarının belirlenen temalarında yer alan etkinliklerin gerçekleştirilme düzeyini belirlemek amacıyla her bir etkinlik incelenerek durum tespiti yapılmıştır. Elde edilen verilere göre, incelenen kitaplarındaki gerçekleştirilen etkinliklerin gerçekleştirilmeyenlerden oransal olarak fazla olsa da öğrenci çalışma kitaplarının işlevsel olarak kullanılmadığı kanaatine varılmıştır.

  7. Almanca Derslerinde Metne Dayalı Dil Bilgisi Öğretiminin On Birinci Sınıf Öğrencilerinin Dil Bilgisi Başarısına Etkisi Impact Of Teaching Grammar Through Text On 11th Grade Students’ Grammar Achievement In German Lessons

    Directory of Open Access Journals (Sweden)

    Bülent KIRMIZI


    ığını belirlemektir. Öğrencilerin belirlenen dil bilgisi konularındaki becerilerini ölçmek amacıyla yirmi sorudan oluşan çoktan seçmeli bir test hazırlanmıştır. Çalışmanın evreni, 2010-2011 eğitim-öğretim yılında Adana’da bulunan iki farklı Anadolu Lisesinin 179 (deney grubu 89 ve kontrol grubu 90 on birinci sınıf öğrencisinden oluşmaktadır. Araştırmaya dâhil edilen ve aralarında Almanca dil bilgisi bakımından anlamlı bir fark bulunmayan Piri Reis Anadolu Lisesi kontrol grubu; Adana Anadolu Lisesi de deney grubu olarak alınmıştır. Çalışmanın başlangıcında her iki gruba ön test uygulanmıştır. Uygulama materyali olarak da Deney grubu öğrencilerine “Grammatik Geschichten” (Aral & Haase, 2011 kitabından, hedef dil bilgisi kurallarına uygun metinler olan “Mein Alptraum” ve “die Lüge” adlı okuma parçaları seçilmiş ve bunlara dayalı olarak etkinlikler hazırlanarak deney grubuna on iki saat süresince uygulanmıştır. Her iki gruba son test uygulanarak toplanan verilerin analizinde SPSS 11,5 programı kullanılmıştır. Elde edilen veriler, t-testi kullanılarak çözümlenmiş ve sonuç olarak, deney grubundaki öğrencilerin kontrol grubundaki öğrencilere göre daha başarılı oldukları tespit edilmiştir. Almancanın ikinci yabancı dil olarak öğretiminde metinlerden daha fazla yararlanılmalıdır. Gramer öğretiminde metin odaklı yöntemle diğer yöntemler karşılaştırılmalı ve öğrenciler üzerindeki etkileri araştırılmalıdır.


    Directory of Open Access Journals (Sweden)

    Murat TUNCER


    ılarak tek faktörlü yapısında karar kılınmış, ölçeğin cronbach alfa katsayısı .84 bulunmuştur. Hazırlanan ölçek Tunceli Meslek Yüksekokulunun farklı bölümlerinde öğrenim gören 430 öğrenciye uygulanmıştır. Ölçek uygulamasıyla elde edilen verilerin analizinde Bağımsız gruplar t testi, Anova testi, Mann Whitney U testi, Kruskal Wallis H ve Tukey HSD testinden yararlanılmıştır. Analiz sonuçlarına göre Meslek yüksek okulu öğrencilerinin gelecek beklentileri arasında cinsiyet değişkeni göre kız öğrenciler lehine anlamlı fark bulunmuştur. Ayrıca öğrencilerin gelecek beklentileri arasında 3-4 kardeşe sahip öğrenciler ile 5 ve daha fazla kardeş sayısına sahip öğrenciler arasında da anlamlı fark bulunmuştur. Öğrencilerin gelecek beklentileri anlamında küreselleşme ve teknolojiye bağlı olarak yaşadıklarına inanılan belirsizliklerin giderilmesinde sektörle olan ilişkinin güçlendirilmesinin yarar getireceği düşünülmektedir. Bunun yanında seçmeli dersler ya da esnek eğitim modelleriyle eğitim alınan mesleki programın dışında meslek dallarında eğitim verilerek geleceğe daha hazır kılınmaları önerilmektedir.

  9. Reconstructing the post-LGM decay of the Eurasian Ice Sheets with Ice Sheet Models; data-model comparison and focus on the Storfjorden (Svalbard) ice stream dynamics history (United States)

    Petrini, Michele; Kirchner, Nina; Colleoni, Florence; Camerlenghi, Angelo; Rebesco, Michele; Lucchi, Renata G.; Forte, Emanuele; Colucci, Renato R.


    climate simulation. In this presentation, we will show work in progress, address open issues, and sketch future work. In particular, we invite the community to suggest possibilities for model-data comparison and integration. Liu, Z., Otto-Bliesner, B.L., He, F., Brady, E.C., Tomas, R., Clark, P.U., Carlson, A.E., Lynch-Stieglitz, J., Curry, W., Brook, E. and Erickson, D., 2009. Transient simulation of last deglaciation with a new mechanism for Bólling-Alleród warming. Science, 325(5938), pp.310-314. Lucchi, R.G., Camerlenghi, A., Rebesco, M., Colmenero-Hidalgo, E., Sierro, F.J., Sagnotti, L., Urgeles, R., Melis, R., Morigi, C., Bárcena, M.A. and Giorgetti, G., 2013. Postglacial sedimentary processes on the Storfjorden and Kveithola trough mouth fans: Significance of extreme glacimarine sedimentation. Global and planetary change, 111, pp.309-326. Martin, M.A., Winkelmann, R., Haseloff, M., Albrecht, T., Bueler, E., Khroulev, C. and Levermann, A., 2011. The Potsdam Parallel Ice Sheet Model (PISM-PIK)-Part 2: Dynamic equilibrium simulation of the Antarctic ice sheet. The Cryosphere, 5(3), pp.727-740. Pedrosa, M.T., Camerlenghi, A., De Mol, B., Urgeles, R., Rebesco, M. and Lucchi, R.G., 2011. Seabed morphology and shallow sedimentary structure of the Storfjorden and Kveithola trough-mouth fans (north west Barents Sea). Marine Geology, 286(1), pp.65-81. Pollard, D. and DeConto, R.M., 2012. Description of a hybrid ice sheet-shelf model, and application to Antarctica. Geoscientific Model Development, 5(5), pp.1273-1295. Rebesco, M., Liu, Y., Camerlenghi, A., Winsborrow, M., Laberg, J.S., Caburlotto, A., Diviacco, P., Accettella, D., Sauli, C., Wardell, N. and Tomini, I., 2011. Deglaciation of the western margin of the Barents Sea Ice Sheet-a swath bathymetric and sub-bottom seismic study from the Kveithola Trough. Marine Geology, 279(1), pp.141-147. Rebesco, M., Laberg, J., Pedrosa, M., Camerlenghi, A., Lucchi, R., Zgur, F. and Wardell, N., 2013. Onset and growth of Trough

  10. AAS 228: Day 1 morning (United States)

    Kohler, Susanna


    Kohler)The first press conference of the meeting featured four speakers discussing some of the latest developments in the field of exoplanet and brown dwarfs.Artists impression of the surface of a massive, planet-like body being devoured by a white dwarf. [A. Hara/C. Melis/W. M. Keck Observatory]First up was Carl Melis (UC San Diego), who discussed the discovery of a rocky exoplanetary body currently being shredded by a white dwarf. As the white dwarfs strong gravitational pull tears the body apart, we can observe the material pulled from its surface layers. These observations made by Keck Observatory and Hubble indicate that the body might have been Earth-like, with an outer surface of made up of limestone. Heres the press release.Next, Avi Shporer (NASA Jet Propulsion Laboratory) spoke about the first transiting brown dwarf found in K2 mission data. Stars like companionship, but the companions are usually other massive stars, or Jupiter-size or smaller planets. Companions with the mass and size of brown dwarfs are uncommon, leading to the term brown dwarf desert. The brown dwarf found by K2 marks the 12th transiting brown dwarf we have discovered.Jerome Orosz (San Diego State University) was up next, presenting the largest and longest-period circumbinary planet yet discovered. This planet is in an orbit with a 3-year period around a two-star binary system (think Tatooine!). This is the longest orbital period of any confirmed transiting exoplanet, and this Jupiter-sized planet, which is in the circumbinarys habitable zone, is the largest circumbinary planet weve observed. Heres the press release.Jerome Orosz on the largest and longest-period circumbinary planet found in Kepler data #aas228 #tatooine astrobites (@astrobites) June 13, 2016Finally, Sean Mills (University of Chicago) spoke about Kepler-108, a giant planet system in which the two exoplanets dont orbit within the same plane. This is detectable because the transits of these planets

  11. PREFACE: First Mediterranean Conference on Classical and Quantum Gravity (MCCQG 2009) (United States)

    Basilakos, Spyros; Cadoni, Mariano; Cavaglia, Marco; Christodoulakis, Theodosios; Vagenas, Elias C.


    , India) Liberati, Stefano (SISSA, Trieste, Italy) Lopez-Villarejo, Juan Jose (Dep. de Física Teorica, Univ. Autonoma de Madrid, Spain) Louko, Jorma (University of Nottingham, UK) Lusanna, Luca (Sezione INFN di Firenze, Italy) Majumdar, Archan S (S N Bose National Centre for Basic Sciences, India) Melis, Maurizio (Università di Cagliari and INFN, Italy) Menotti, Pietro (Department of Physics, University of Pisa, Italy) Mignemi, Salvatore (Università di Cagliari, Italy) Monni, Cristina (Università di Cagliari and INFN, Italy) Pani, Paolo (Università di Cagliari and INFN, Italy) Papazoglou, Antonios (ICG, University of Portsmouth, UK) Páramos, Jorge (Instituto de Plasmas e Fusāo Nuclear, IST, Portugal) Pavsic, Matej (Jozef Stefan Institute, Slovenia) Perivolaropoulos, Leandros (University of Ioannina, Greece) Plionis, Manolis (Institute of Astronomy & Astrophysics, National Observatory of Athens, Greece) Pons, Josep (Universitat de Barcelona, Spain) Pouri, Athina (University of Athens, Greece) Radicella, Ninfa (Polytechnic of Turin, Italy) Rocha, Jorge (IST, Portugal) Russo, Jorge (ICREA, Universitat de Barcelona, Spain) Sakai, Norisuke (Department of Mathematics, Tokyo Woman's Christian University, Japan) Sakellariadou, Mairi (Department of Physics, King's College University of London, UK) Salisbury, Donald (Austin College, USA and MPI for the History of Science, Germany) Shnir, Yakov (National University of Ireland, Maynooth and DIAS, Ireland) Skenderis, Kostas (Institute for Theoretical Physics, University of Amsterdam, Netherlands) Sotiriou, Thomas (DAMTP, Cambridge, UK) Sundermeyer, Kurt (Free University Berlin Institute for Theoretical Physics, Germany) Tartaglia, Angelo (DIFIS, Politecnico and INFN, Torino, Italy) Vagenas, Elias (RCAAM, Academy of Athens, Greece) Wallden, Petros (Raman Research Institute, India) Wang, Bin (Fudan University, China) Weinfurtner, Silke (University of British Columbia, Canada) Zampeli, Mando (National Technical University of

  12. Selected Abstracts of the 20th National Congress of the Italian Society of Perinatal Medicine (Società Italiana di Medicina Perinatale, SIMP; Catania (Italy; March 22-24, 2018; Session “Perinatal medicine”

    Directory of Open Access Journals (Sweden)

    --- Various Authors



  13. Control of the geomorphic evolution of an active crater: Popocatpetl (Mexico) 1994-2003. (United States)

    Andrés, N.; Zamorano, J. J.; Palacios, D.; Macias, J. L.; Sanjosé, J. J.


    . References.- Cruz-Reyna, S. de la; Meli, R.; Macías, J.L.; Castillo, F.; & Cabrera, B., 1998. Cyclical dome extrusions that by late 1997 filled one-third of crater capacity, In Smithsonian-GVP Monthly Reports, Popocatépetl, Smithsonian Institution. Bull. Glob. Volcanism Netw, (GVN) 23 (2), 2 - 4. Donnadieu, F.; Kelfoun, K.; Van Wyk de Vries, B.; Decchi, E.; & Merle, O., 2003. Digital photogrammetry as a tool in analogue modelling: applications to volcano instability, Journal of Volcanology and Geothermal Research, 123 (1-2), 161-180. Macías, J.L. & Siebe, C., 2005. Popocatépetl crater filled to the brim: significance for hazard evaluation, Journal of Volcanology and Geothermal Research (141) 327-330. Martín-Del Pozzo, A.L.; Cifuentes-Nava, G.; Cabral-Cano, E.; Bonifaz, F.; Correa, I.; & Mendiola, I.F., 2003. Timing magma ascent at Popocatepetl Volcano, Mexico, 2000-2001, Journal of Volcanology and Geothermal Research ,125, 107-120. Matiella, M.A.; Watson, I.M.; Delgado, H.; Rose, W.I.; , Cárdenas, L.; & Realmuro, V.J., 2008, Volcanic emissions from Popocatépetl volcano, Mexico, quantified using Moderate Resolution Imaging Spectroradiometer (MODIS) infrared data: A case study of the December 2000-January 2001 emissions, Journal of Volcanology and Geothermal Research, 170, 1-2, 76-85. Procter, J.N.; Platz, T.; & Cronin, S.J., 2006. A remnant summit lava dome and its influence on future eruptive hazards, Geophysical Research Abstracts, Vol. 8, 10211. Schilling, S.P.; Ramsey, D.W.; Messerich, J.A.; & Thompson, R.A., 2006. Map: Rebuilding Mount St. Helens. U.S. Geological Survey Scientific Investigations Map 2928. Tanarro, L. M.; Zamorano, J.J.; & Palacios, D., 2005. Glacier degradation and lahar formation on the Popocatépetl volcano (Mexico) during the last eruptive period (1994-2003), Zeitschrift Geomorphologie (140) 73-92. Zamorano, J.J., Gómez, A. 1996 "Análisis geomorfoloógico a detalle,1:10 000 del cráter del volcán Popocatépetl (1989-1996)" IV Reuni

  14. Selected Abstracts of the 12th International Workshop on Neonatology; Cagliari (Italy; October 19-22, 2016

    Directory of Open Access Journals (Sweden)

    --- Various Authors



  15. Selected Abstracts of the 9th International Workshop on Neonatology; Cagliari (Italy; October 23-26, 2013

    Directory of Open Access Journals (Sweden)

    --- Various Authors


    Full Text Available Selected Abstracts of the 9th International Workshop on Neonatology • LEARNED LESSONS, CHANGING PRACTICE AND CUTTING-EDGE RESEARCH • Cagliari (Italy • October 23rd-26th 2013The Workshop has been organized on behalf of Union of European Neonatal and Perinatal Societies, Union of Mediterranean Neonatal Societies, Italian Society of Neonatology, UNICEF, and under the High Patronage of the President of the Italian Republic. ABS 1. Aetiology and type of reference hospital for neonatal transport in Greece during 2012 • S. Mouskou, C. Varakis, D. Pyrros, N. Iacovidou; Athens (Greece ABS 2. Changes in neonatal outcomes of very low birth weight infants in Hospital of Lithuanian University of Health Sciences • K. Stuikiene, R. Tameliene, D. Stoniene, A. Kudreviciene, V. Ivanauskiene; Kaunas (Lithuania ABS 3. Autoimmune liver disease in childhood • Y. Gibo, D. Fanni, P. Van Eyken, S. Nemolato, G. Floris, C. Gerosa; Matsumoto (Japan, Leuven (Belgium and Cagliari (Italy ABS 4. Lactoferrin attenuates intestinal injury afther perinatal hypoxia and hypothermia • N. Barisic, G. Konstantinidis, V. Stojanovic, A. Doronjski, S. Spasojevic; Novi Sad (Serbia ABS 5. Osteopenia in prematurity: case report • K. Stuikiene, R. Tameliene, D. Stoniene, A. Kudreviciene, V. Ivanauskiene; Kaunas (Lithuania ABS 6. Neonatal Bartter syndrome: case report of a very unusual entity • A. Koutroumpa, K. Georgiou, H. Georgaki, F. Anatolitou; Athens (Greece ABS 7. Placental Growth Factor (PlGF and placental function • I. Atzeni, S.F. Deiana, A. Meloni, B. Piras, P. Zedda, S. Soddu, G. Parodo, G. Faa, G.B. Melis, A.M. Paoletti; Cagliari (Italy ABS 8. Neonatal ECMO: initial experience of Hospital de São João • G. Rocha, P. Soares, T. Henriques-Coelho, J. Correia-Pinto, J. Monteiro, H. Guimarães, R. Roncon-Albuquerque Jr; Porto (Portugal ABS 9. GCMS-based metabolomics analysis of urines in hypoxic neonatal piglets • C. Fattuoni, L. Barberini, N. Iacovidou, T

  16. AAS 228: Day 2 morning (United States)

    Kohler, Susanna


    extremely data-rich. The Galaxy Zoo project also suggests the promising prospect of synergizing the help from citizen scientists and machine learning in analyzing extremely large datasets.Extrasolar Planets: Atmospheres (by Leonardo dos Santos)Antonija Oklopi (Caltech) explains that Raman scattering of light, which works similarly to Rayleigh scattering (the process that makes Earths sky blue), can be used in the future to study the atmospheres of exoplanets. Her work is to create model spectra containing these features, from which we can learn about the presence and altitude of atmospheric clouds. Dr. Carl Melis (University of California, San Diego) studies the inner composition of exoplanets by looking at their remnants after they are destroyed by a dying star. His most recent work suggests that there is a differentiated pollution (from the core and the crust of a planet) in the disk orbiting of a white dwarf star. Samuel Grunblatt (University of Hawaii) introduces us to the main subject of his thesis: a hot-Jupiter observed by Keplers K2 mission transiting an evolved, red giant star. They used some pretty tricky data analysis in order to filter out the noise intrinsic to this type of star.Grunblatt shows the K2 transit before and after removal of granulation effects.Avi Shporer (JPL) asks the question: why are hot Jupiters so large? His research aims to study the correlation between stellar irradiation and planetary radius, and in order to have a more complete picture, they need to detect more gas giants on lower stellar irradiation regions. This idea gave rise to LCOGT K2 Warm Jupiter project, which recently discovered a brown dwarf in a long-period orbit around a Sun-like star. Paul Mason (New Mexico State University) proposes that the Milky Way is evolving to a more habitable galaxy, due to the expansion of the universe, the processing of heavier material inside stars, and the general decrease of ionizing radiation.Evolution of Galaxies (by Ben Cook)Tuesday mornings

  17. PREFACE: Fourth Meeting on Constrained Dynamics and Quantum Gravity (United States)

    Cadoni, Mariano; Cavaglia, Marco; Nelson, Jeanette E.


    Cagliari, Italy) Roberto De Pietri (Università di Parma, Italy) Giuseppe De Risi (Università di Bari, Italy) Hans-Thomas Elze (Univ. Federal do Rio de Janeiro, Brasil) Alessandro Fabbri (Università di Bologna, Italy) Sergey Fadeev (VNIIMS, Moscow, Russia) Serena Fagnocchi (Università di Bologna, Italy) Sara Farese (Universidad de Valencia, Spain) Alessandra Feo (Università di Parma, Italy) Dario Francia (Università di Roma Tor Vergata, Italy) Francesco Fucito (Università di Roma Tor Vergata, Italy) Dmitri Fursaev (JINR, Dubna, Russia) Daniel Galehouse (University of Akron, Ohio, USA) Remo Garattini (Università di Bergamo, Italy) Florian Girelli (Perimeter Institute, Waterloo, Canada) Luca Griguolo (Università di Parma, Italy) Daniel Grumiller (Universität Leipzig, Germany) Shinichi Horata (Hayama Center of Advanced Research, Japan) Giorgio Immirzi (Università di Perugia, Italy) Roman Jackiw (MIT, Cambridge, USA) Matyas Karadi (DAMTP, University of Cambridge, UK) Mikhail Katanaev (Steklov Mathematical Institute, Moscow, Russia) Claus Kiefer (Universität Koln, Germany) John Klauder (University of Florida, Gainesville, USA) Pavel Klepac (Masaryk University, Brno, Czech Republic) Jen-Chi Lee (National Chiao-Tung University, Taiwan) Carlos Leiva (Universidad de Tarapacá, Arica, Chile) Stefano Liberati (SISSA/ISAS, Trieste, Italy) Jorma Louko (University of Nottingham, UK) Luca Lusanna (INFN, Sezione di Firenze, Italy) Roy Maartens (University of Portsmouth, UK) Fotini Markopoulou (Perimeter Institute, Waterloo, Canada) Annalisa Marzuoli (Università di Pavia, Italy) Evangelos Melas (QMW, University of London, UK) Maurizio Melis (Università di Cagliary, Italy) Vitaly Melnikov (VNIIMS, Moscow, Russia) Guillermo A. Mena Marugan (CSIC, Madrid, Spain) Pietro Menotti (Università di Pisa, Italy) Salvatore Mignemi (Università di Cagliari, Italy) Aleksandar Mikovic (Universidade Lusófona, Lisboa, Portugal) Leonardo Modesto (Université de la Mediterranée, Marseille

  18. Astrobiology - The New Synthesis (United States)

    Sik, A.; Simon, T.

    to let acids and alkalis into their cells. - Halophiles: these species are identified from salt lakes, salt mines and salt crystals (some of these are 250 million years old). The salt concentration of their cytoplasm is extreme high so the outer salt can not enter. 2. Extremophiles and evolution Jelentősek az extremofilek evolúciós evolution as- pects vonatkozásai, mivel igen sok ősbaktériumot archaea találunk közöttük. A hagyományos nézet, mely szerint az élővilág a baktériumok bacteria és eukar- ióták eukaryotes birodalmára osztható, a 70-es évek végén (Woese et al), 80-as évek elején (Fox et al) ingott meg, amikor a 16S rRNS (az élővilág egyik legkonz- ervatívabb molekuláris szerkezete molecular structure) összehasonlító szekvenciav- izsgálatai comparative sequence analysis alapján kiderült: az ősbaktériumok különválasztása a legmagasabb rendszertani taxonomy level szinten is indokolt, tehát külön birodalmat separate domain képeznek. Az eddigi genomtérképezések genome sequencing során kiderült, hogy az ősbaktériumok egyes génjei csak eukar- iótákban találhatók meg, nagyobb részük pedig teljesen egyedi [14]. Újabb elméletek szerint az eubaktériumok és ősbaktériumok közös őstől származ- nak, az eukarióták pedig az ősbaktériumokból fejlődhettek ki [15]. Az ősbaktériumok az egyetemes őshöz (LUCA - "last universal common ancestor") legközelebb álló élő kövületek living fossils lehetnek. Luca: az RNS-világ RNS world, a ribo-organizmusok ribo organisms utáni első orga- nizmus, amelyben már kialakult a fehérjék proteins és a DNS DNS mai szerepe. Az ősbaktériumok tanulmányozásával tehát a közel 4 milliárd évvel ezelőtti földi körülményekre következtethetünk. Az utóbbi években a földkéregben felfedezett gazdag extremofil-társulások alapján megdőlni látszik az a hagyományos nézet, mely szerint Luca egy meleg felszíni pocsolyában tenyészett, s divatoss

  19. Bilimsel Toplantı Duyuruları

    Directory of Open Access Journals (Sweden)

    Adli Tıp Uzmanları Derneği ATUD


    .Ulusal Kongresi 26-\t28 Kasım 1999, Ankara Üniv.Tıp Fakültesi Morfoloji Binası-Ankara İletişim: Ankara Tabip Odası, Hanımeli Sok. No. 16/2 Sıhhiye-ANKARA Tel:229 55 70 24\tCezaevleri Sempozyumu 19 Aralık 1999, Adana İletişim: Türk Tabipleri Birliği Merkez Konseyi Dr. Ümit Erkol, TTB Merkez Konseyi Mithatpaşa Cad. No.62/18 Kızılay-ANKARA Tel:4l8 31 56 25\t15th Annual International Symposium on the Forensic Science 5-10 March 2000 Queensland, Australia Information: Michael Holohan, Australian and New Zealand Forensic Science Society, Queensland Branch 26\tInternational Conference on Forensic Science 2,\t5 May 2000, Dublin, Ireland Chairperson: Mr. Liam Fleury Tel: +353-1-6662936 Secretary: Dr. Tom Hannigan Tel: +353-1-6662950 FAX: +353-1-6662929 27\tThe Third Joint Meeting of the California Association of Criminalists and the Forensic Science Society (CAC/FSS May 8 - 12, 2000, Napa, CA. Telephone 510-223-7374. FAX 510-222-8887. Web 28\tIV. Adli Bilimler Kongresi 10-\t13 Mayıs 2000, İstanbul İ.Ü. İstanbul Tıp Fakültesi Adli Tıp AD ve Adli Tıp Uzmanları Derneği (ATUD İletişim: Dr. Eren Kaıpuzoğlu, İ.Ü. İstanbul Tıp Fakültesi Adli Tıp AD 34390, Çapa, İstanbul Tel :0-212-6361179 29\tDNA Forensics May 31-June 2, 2000, Cambridge Healthtech Institute 1037 Chestnut Street, Newton Upper Falls, MA 02164 Tel: 617-630-1300 Fax: 617-630-1325 E-Mail: 30\tAAFS Annual Meeting. Association for Crime Scene Reconstruction Training Conference 1999. 14-\t16 June 2000 Netherlands. ENFSI Forensic IT-working group meeting - Forensic IT meeting of ENFSI

  20. Selected Abstracts of the 13th International Workshop on Neonatology; Cagliari (Italy; October 25th-28th, 2017

    Directory of Open Access Journals (Sweden)

    --- Various Authors