Sample records for iraldo michela melis

  1. Michela Marzano (dir.), Dictionnaire de la violence


    Sessi, Frediano


    Énorme somme de plus de 1 530 pages, le tout récent Dictionnaire de la violence, dirigé par la philosophe Michela Marzano, constitue une référence parmi la centaine de dictionnaires existants édités par les PUF. Alors que nombre des encyclopédies proposées par la prestigieuse maison d’édition synthétisent des savoirs disciplinaires, l’ambition est ici de proposer un regard thématique exhaustif, à l’image du dictionnaire du racisme et de l’antiracisme attendu depuis quelques années. Dans un co...

  2. Michela/Miki: storia vera di un uomo che non si è mai sentito donna

    Directory of Open Access Journals (Sweden)

    Anna Paola Lacatena


    Full Text Available Quella raccontata da un paziente del Dipartimento Dipendenze Patologiche della ASL di Taranto, Michela prima e Miki poi, è la storia di un'infanzia difficile, consumata in una casa in cui la violenza e la scarsa attenzione nei confronti dei bisogni sono la cifra principale. La protagonista non accetta le sue sembianze femminili, non si sente donna, vive come se non lo fosse. Da subito, si percepisce uomo in un corpo femminile. Miki non è un personaggio frutto di fantasia, dove quest'ultima rischierebbe di essere superata per drammaticità dalla realtà. È una persona che non ha saputo né voluto coltivare una menzogna esistenziale. Inizialmente provandoci con tutta la rabbia verso la vita di cui Michela era capace e successivamente con la consapevolezza di non essere solo distruttività e rabbia. Il desiderio profondo di vedere realizzata la propria autenticità lo conduce al rifiuto di darsi in pasto all'annientamento completo decidendo, dopo un accumulo di sofferenze e rifiuti, di decidere chi e come essere nel mondo. Rifiutando il rifiuto, cercandosi profondamente, la sfida non è stata più contro il resto del mondo ma a favore di sé e, conseguentemente degli Altri.

  3. Bartolomé Meliá

    Directory of Open Access Journals (Sweden)


    Full Text Available Entrevista (en francés/Entretien Presentation Bartomeu Meliá est né à Porreres, Mayorque, Espagne en 1932. Jésuite, il est arrivé au Paraguay en 1954 où il a commencé l’étude de la langue et de la culture guarani avec le père Antonio Guasch comme professeur. Il a obtenu un doctorat de l’Université de Strasbourg en 1969 sur le thème « La création d’un langage chrétien dans les réductions des guarani au Paraguay ». Disciple et collaborateur de Don León Cardogan, Bartomeu Meliá a été professeu...

  4. Preliminary approach of the MELiSSA loop energy balance (United States)

    Poulet, Lucie; Lamaze, Brigitte; Lebrun, Jean

    Long duration missions, such as the establishment of permanent bases on the lunar surface or the travel to Mars, require a huge amount of life support consumables (e.g. food, water and oxygen). Current rockets are at the moment unable to launch such a mass from Earth. Consequently Regenerative Life Support Systems are necessary to sustain long-term manned space mission to increase recycling rates and so reduce the launched mass. Thus the European and Canadian research has been concentrating on the MELiSSA (Micro-Ecological Life Support System Alternative) project over the last 20 years. MELiSSA is an Environmental Controlled Life Support System (ECLSS), i.e. a closed regenerative loop inspired of a lake ecosystem. Using light as a source of energy, MELiSSA's goal is the recovery of food, water and oxygen from CO2 and organic wastes, using microorganisms and higher plants. The architecture of a ECLSS depends widely on the mission scenario. To compare several ECLSS architectures and in order to be able to evaluate them, ESA is developing a multi criteria evaluation tool: ALISSE (Advanced LIfe Support System Evaluator). One of these criteria is the energy needed to operate the ECLSS. Unlike other criteria like the physical mass, the energy criterion has not been investigated yet and needs hence a detailed analysis. It will consequently be the focus of this study. The main objective of the work presented here is to develop a dynamic tool able to estimate the energy balance for several configurations of the MELiSSA loop. The first step consists in establishing the energy balance using concrete figures from the MELiSSA Pilot Plant (MPP). This facility located at the Universitat Autonoma de Barcelona (UAB) is aimed at the ground demonstration of the MELiSSA loop. The MELiSSA loop is structured on several subsystems; each of them is characterized by supplies, exhausts and process reactions. For the purpose of this study (i.e. a generic tool) the solver EES (Engineering

  5. MELiSSA Food Characterization general approach and current status (United States)

    Weihreter, Martin; Chaerle, Laury; Secco, Benjamin; Molders, Katrien; van der Straeten, Dominique; Duliere, Eric; Pieters, Serge; Maclean, Heather; Dochain, Denis; Quinet, Muriel; Lutts, Stanley; Graham, Thomas; Stasiak, Michael; Rondeau Vuk, Theresa; Zheng, Youbin; Dixon, Mike; Laniau, Martine; Larreture, Alain; Timsit, Michel; Aronne, Giovanna; Barbieri, Giancarlo; Buonomo, Roberta; Veronica; Paradiso, Roberta; de Pascale, Stafania; Galbiati, Massimo; Troia, A. R.; Nobili, Matteo; Bucchieri, Lorenzo; Page, Valérie; Feller, Urs; Lasseur, Christophe

    Higher plants play an important role in closed ecological life support systems as oxygen pro-ducers, carbon dioxide and water recyclers, and as a food source. For an integration of higher plant chambers into the MELiSSA (Micro Ecological Life Support System Alternative) loop, a detailed characterization and optimization of the full food production and preparation chain is needed. This implies the prediction and control of the nutritional quality of the final products consumed by the crew, the prediction of the wastes quality and quantity produced along the chain for further waste treatment (MELiSSA waste treatment) and the optimization of overall efficiencies. To reach this goal several issues have to be studied in an integrated manner: the physiological responses of crops to a range of environmental parameters, crop yield efficiencies and respective ratio and composition of edible and inedible biomass, the processability and storability of the produced food and last but not least composition of wastes in view of further degradation (fiber content). Within the Food Characterization (FC) project several compar-ative plant growth bench tests were carried out to obtain preliminary data regarding these aspects. Four pre-selected cultivars of each of the four energy-rich crops with worldwide usage -wheat, durum wheat, potato and soybean -were grown under well-characterized environmental conditions. The different cultivars of each species are screened for their performance in view of a closed loop application by parameter ranking. This comprises the characterization of edi-ble/inedible biomass ratio, nutritional quality, processability and overall performance under the specific conditions of hydroponic cultivation and artificial illumination. A second closely linked goal of the FC project is to develop a mechanistic physiological plant model, which will ease the integration of higher plants compartments in the MELiSSA concept by virtue of its predictive abilities

  6. The MELiSSA Pilot Plant Facility: Objectives and Integration Strategy (United States)

    Gødia, F.; Pérez, J.; Albiol, J.; Lasseur, C.; Lamaze, B.; Ordónez, L.

    MELiSSA Micro-Ecological Life Support System Alternative is a closed artificial ecosystem intended as a tool for the development of a bio-regenerative life support system for long-term manned missions i e planetary base For its study and implementation the MELiSSA loop has been divided in five interconnected compartments organized in three different loops solid liquid and gas This compartments are microbial bioreactors and higher plant chambers The MELiSSA Pilot Plant facility an ESA External Laboratory located at Universitat Aut o noma of Barcelona has been conceived to achieve a preliminary terrestrial demonstration of the MELiSSA concept at pilot scale using animals as a model to substitute the crew The experience gained in the operation of such a facility will be highly relevant for planning future life support systems in Space In order to fulfill this challenging objective a number of steps have to be covered from the individual design of each compartment to the continuous operation of the complete loop with all compartments interconnected operating in sterile conditions in controlled conditions and in a biosafe manner A new site for the MELISSA Pilot Plant facility has been recently completed to host the final integration of the complete loop The contribution will cover the general design aspects of the loop including the current state of the different compartments and their interconnection with solid liquid and gas loops and the future plans of how these different elements will be integrated to achieve the final

  7. MELiSSA Pilot Plant: A facility for ground demonstration of a closed life support system (United States)

    Godia, Francesc; Fossen, Arnaud; Peiro, Enrique; Gerbi, Olivier; Dussap, Gilles; Leys, Natalie; Arnau, Carolina; Milian, Ernest

    MELiSSA (Micro Ecological Life Support System Alternative) is an international collaborative effort focused on the development of a Life Support System for long-term Space missions. The goals of the MELiSSA loop are the recovery of food, water and oxygen from wastes, i.e. CO2 and organic wastes, using light as a source of energy. It is conceived as a series of compartments, each one performing a specific function within this cycle, inspired in the terrestrial ecological systems. Each one of the compartments is colonized with specific bacteria or higher plants depending on its dedicated function. Therefore, its design and operational conditions should guarantee that only a given specific biological activity takes place in each compartment. Moreover, this has to be done in a controlled manner, both at the subsystems level (i.e., compartments) and at the overall system level (i.e., complete loop). In order to achieve the complete operation of such a Closed Ecological System, in a first step each compartment has to be developed at individual level, and its operation demonstrated under its associated control law. In a second step, the complete loop needs to be integrated by the connection of the different compartments in the gas, loop and solid phases. An extensive demonstration of MELiSSA loop under terrestrial conditions is a mandatory step in the process of its adaptation to space. This is the main goal of the MPP. The demonstration scenario for the MPP is the respiration equivalent of a human being, and production of 20 percent of the diet of one person. To serve this goal, the different compartments of the MELiSSA loop have been designed and sized at the pilot scale level, and further characterized. Nowadays, the focus of the MELiSSA Pilot Plant is on the integration of its compartments. To this end, the integration challenge is concentrated in three compartments devoted to the following functions: nitrification (Compartment 3, an axenic co-culture of Nitrosomonas

  8. Higher Plants in Space for MELiSSA -Literature Review and Future Directions (United States)

    Zabrodina, Marina; Kittang, Ann-Iren; Coelho, Liz Helena; Karoliussen, Irene; Aase Wolff, Silje; Iversen, Tor-Henning

    The human exploration of space requires the development of closed life support systems to regenerate oxygen, purify water, and produce food. MELiSSA (Micro-Ecological Life Support System Alternative) is a model system for advanced life support based on different microbial species and higher plants. The main objective of the LiRHiPliSMe (Literature Review of Higher Plants in Space for MELiSSA) project was to elaborate the preliminary roadmap for higher plant research activities for the MELiSSA project Phase 2 (Preliminary Space Experiments). The first task was to establish an understanding of the current knowledge concerning how higher plant will adapt to Moon/Mars physical factors different from Earth with focus on reduced gravity, space radiation, variations in magnetic field and combined effects of these factors. The literature related to how Moon/Mars physical factors can affect genetic processes, growth regulators, development, morphology, water and nutrients transport, gas exchange and metabolism of higher plants during one life cycle were collected. The possible effects of the space environment on the plant role as a food and on the mass balance in a Life Support System that includes a Higher Plant Compartment are reviewed. Based on this literature review there was made an assessment of where new or extended scientific knowledge about space factors effects on higher plant growth and development is needed. The requirements for research activities on higher plants in enclosed life support systems were identified. The required higher plant research activities for MELiSSA phase 2 both on ground and in space were placed in a timescale from the present until higher plants can be grown in closed life support systems on Moon and Mars.

  9. Surviving space flight: case study on MELiSSA's CIII nitrifying compartment (United States)

    Ilgrande, Chiara; Lasseur, Christophe; Mastroleo, Felice; Paille, Christel; Leys, Natalie; Morozova, Julia; Ilyin, Vyacheslav; Clauwaert, Peter; Christiaens, Marlies E. R.; Lindeboom, Ralph E. F.; Vlaeminck, Siegfried; Prat, Delphine; Arroyo, Jose M. C.; Conincx, Ilse; Van Hoey, Olivier; Roume, Hugo; Udert, Kai; Sas, Benedikt


    Space synthetic biology offers key opportunities for long-term space missions. Planets mining, terraformation, space medicine and Life Support technologies would all benefit from an integrative biological approach. However, space is a harsh environment for life: microgravity, temperature, UV and cosmic radiation can affect the health and functionality of microorganisms and plants, possibly preventing the optimal performance of the systems. The European Space Agency's Life Support System (MELiSSA) has been developed as a model for future long term Space missions and Space habitation. MELiSSA is a 5 compartment artificial ecosystem with microorganisms and higher, that aims at completely recycling gas, liquid and solid waste. In this study, the survival and functional activity after Lower Earth Orbit conditions of microbial nitrogen conversions, relevant for MELiSSA's CIII compartment, was tested. Synthetic communities containing Nitrosomonas europeae, Nitrosomonas ureae, Nitrobacter winogradskyi, Nitrospira moscoviensis and Cupriavidus pinatubonensis were exposed to the Lower Earth Orbit conditions of the International Space Station (ISS) for 7 days. Nitrosomonas europeae, Nitrobacter winogradskyi, Cupriavidus pinatubonensis, and three mixed communities (a urine nitrification sludge, a sludge containing aerobic ammonia oxidizing bacteria and anammox bacteria (OLAND), and an aquaculture sludge containing ammonia oxidizing archaea) were exposed to Lower Earth Orbit conditions for 44 days. Survival after both space flights was demonstrated because nitritation, nitratation, denitrification and anammox activity could be restored at a rate comparable to ground storage conditions. Our results validate the potential survival feasibility and suggest future space applications for N-related microorganisms.

  10. MELiSSA third compartment: Nitrosomonas europaea and Nitrobacter winogradskyi axenic cultures in bioreactors (United States)

    Cruvellier, Nelly; Lasseur, Christophe; Poughon, Laurent; Creuly, Catherine; Dussap, Gilles

    Nitrogen is a key element for the life and its balance on Earth is regulated by the nitrogen cycle. This loop includes several steps among which nitrification that permits the transformation of the ammonium into nitrate. The MELiSSA loop is an artificial ecosystem designed for life support systems (LSS). It is based on the carbon and nitrogen cycles and the recycling of the non-edible part of the higher plants and the waste produced by the crew. In this order, all the wastes are collected in the first compartment to degrade them into organic acids and CO2. These compounds are joining the second compartment which is a photoheterotrophic compartment where at the outlet an organic-free medium containing ammonium is produced. This solution will be the substrate of the third compartment where nitrification is done. This compartment has to oxidize the ammonium into nitrate, and this biological reaction needs two steps. In the MELiSSA loop, the nitrification is carried out by two bacteria: Nitrosomonas europaea ATCC® 19718™ which is oxidizing ammonia into nitrite and Nitrobacter winogradskyi ATCC® 25391™ which is producing nitrate from nitrite in the third compartment. These two bacteria are growing in axenic conditions on a fixed bed bioreactor filled with Biostyr® beads. The nitrogen compounds are controlled by Ionic Chromatography and colorimetric titration for each sample. The work presented here deals with the culture of both bacteria in pure cultures and mixed cultures in stirred and aerated bioreactors of different volumes. The first aim of our work is the characterization of the bacteria growth in bioreactors and in the nitrifying fixed-bed column. The experimental results confirm that the growth is slow; the maximal growth rate in suspended cultures is 0.054h-1 for Nitrosomonas europaea and 0.022h-1 for Nitrobacter winogradskyi. Mixed cultures are difficult to control and operate but one could be done for more than 500 hours. The characterization of the

  11. Isobaculum melis gen. nov., sp. nov., a Carnobacterium-like organism isolated from the intestine of a badger. (United States)

    Collins, Matthhew D; Hutson, Roger A; Foster, Geoffrey; Falsen, Enevold; Weiss, Norbert


    Phenotypic and phylogenetic studies were performed on a hitherto undescribed facultatively anaerobic, catalase-negative, gram-positive rod-shaped organism, strain M577-94T, isolated from the small intestine of a dead badger. It resembled carnobacteria in terms of its long-chain cellular fatty acid composition, but differed markedly from the latter in possessing a cell-wall murein based on L-lysine (type L-Lys-L-Thr-Gly). Comparative 16S rRNA gene sequencing showed that the unknown bacterium represents a new line closely related to, albeit distinct from, the genera Carnobacterium and Desemzia. On the basis of phylogenetic and phenotypic evidence, it is proposed that strain M577-94T be classified as Isobaculum melis gen. nov., sp. nov. The type strain of Isobaculum melis is CCUG 37660T (= DSM 13760T).

  12. Simulation of the MELiSSA closed loop system as a tool to define its integration strategy (United States)

    Poughon, L.; Farges, B.; Dussap, C. G.; Godia, F.; Lasseur, C.


    Inspired by a terrestrial ecosystem, Micro-Ecological Life Support System Alternative (MELiSSA) is a project focused on a closed-loop life support system intended for future long-term manned missions (Moon and Mars bases). Started by the ESA in 1989, this 5-compartment concept has evolved through a mechanistic engineering approach designed to acquire both theoretical and technical knowledge. In its current state of development, the project can now start to demonstrate the MELiSSA loop concept at pilot scale. Thus, an integration strategy for a MELiSSA Pilot Plant (MPP) has been defined, describing the different test phases and connections between compartments. The integration steps are due to be started in 2008 and completed with a complete operational loop in 2015. The ultimate objective is to achieve a closed liquid and gas loop fulfiling 100% of oxygen requirements and at least 20% of food requirements for one-man. Although the integration logic could start with the most advanced processes in terms of knowledge and hardware development, this logic needs to be expanded to encompass a high-level simulation policy. This simulation exercise will make it possible to run effective demonstrations of each independent process, followed by progressive coupling with other processes in operational conditions mirroring as far as possible the final configuration. The theoretical approach described in this paper is based on mass balance models of each MELiSSA compartment which are used to simulate each integration step and the complete MPP loop itself. These simulations will help identify criticalities in each integration step and check consistency between objectives, flows, recycling efficiencies and sizing of the pilot reactors. An MPP scenario compatible with current knowledge on the operation of the pilot reactors was investigated, and the theoretical performances of the system were compared against the objectives assigned to the MPP. This scenario makes it possible to

  13. Dynamic aspects and controllability of the MELiSSA project: a bioregenerative system to provide life support in space. (United States)

    Farges, Bérangère; Poughon, Laurent; Creuly, Catherine; Cornet, Jean-François; Dussap, Claude-Gilles; Lasseur, Christophe


    Manmade ecosystems differ from their prototype biosphere by the principle of control. The Earth Biosphere is sustainable by stochastic control and very large time constants. By contrast, in a closed ecosystem such as the micro-ecological life support system alternative (MELiSSA system) developed by the European Space Agency for space exploration, a deterministic control is a prerequisite of sustainable existence. MELiSSA is an integrated sum of interconnected biological subsystems. On one hand, all unit operations in charge of the elementary functions constitutive of the entire life support system are studied until a thorough understanding and mathematical modelling. On the other hand, the systemic approach of complex, highly branched systems with feedback loops is performed. This leads to study in the same perspective, with the same degree of accuracy and with the same language, waste degradation, water recycling, atmosphere revitalisation and food production systems prior to the integration of knowledge-based control models. This paper presents the mathematical modelling of the MELiSSA system and the interface between the control strategy of the entire system and the control of the bioreactors.

  14. The influence of quorum sensing in compartment II of the MELiSSA loop (United States)

    Condori, Sandra; Mastroleo, Felice; Wattiez, Ruddy; Leys, Natalie

    MELiSSA (Micro-Ecological Life Support System Alternative) has been conceived as a 5 compartments microorganisms and higher plants recycling system for long haul space flights. Rhodospirillum rubrum S1H colonizes compartment II. Previous work reported that continuous culture of the bacterium in a photobioreactor could lead to thick biofilm formation, leading to bioreactor arrest. Our aim is to investigate the unknown quorum sensing (QS) system of R. rubrum S1H, specifically under MELiSSA relevant culture conditions meaning light anaerobic (LAN) and using acetate as carbon source. In that purpose an autoinducer synthase gene (Rru_A3396) knockout mutant was constructed by allelic exchange generating strain M68. In addition phenotypic comparison between wild type (WT) and M68 was performed. Results of thin layer chromatography assay where Agrobacterium tumefaciens NT1 have been used as reporter strain showed that WT produces acyl-homoserine lactones (AHLs) from C4 to C12 acyl carbon chain length; however, in M68 no AHLs were detected confirming that gene Rru_A3396 (named rruI) encodes an autoinducer synthase. Interestingly under a low shear or static environment M68 showed cell aggregation similar as reported in a closely related bacterium Rhodobacter sphaeroides (cerI mutant). In contrast to WT, M68 did not form biofilm and exhibited a decreased motility and pigment content. M68 vs wild type transcriptomics results showed that 326 genes were statistically significant differentially expressed. Downregulation of genes related to photosynthesis e.g., reaction center subunits, light harvesting complex and photosynthetic assembly proteins was observed. Similar results were obtained for preliminary proteomic analysis. Results obtained showed that in R. rubrum S1H the AHL-based QS system regulates almost 8% of the genome which is linked to biofilm formation among other biological processes described above. Since strain M68 could not be used in compartment II due to its less

  15. Integration of a Higher Plant Chamber into the European Space Agency's MELiSSA Pilot Plant: The Canadian Role in Advanced Life Support Test-Bed Development (United States)

    Waters, Geoffrey; Lawson, Jamie; Gidzinski, Danuta; Stasiak, Michael; Dixon, Mike; Peiro, Enrique; Godia, Francesc; Paille, Christel; Fossen, Arnaud; Lamaze, Brigitte; Lasseur, Christophe

    The European Space Agency's Micro-Ecological Life Support System Alternative (MELiSSA) project has been conceived as a tool for developing the technology of future biological life support systems required for long-term human space exploration missions to the Moon or Mars. The main life support functions of MELiSSA are the recycling of waste (inedible plant biomass, human excrement), carbon dioxide and minerals and the production of food, fresh water and air revitalization. Based on the principle of an aquatic ecosystem, MELiSSA is comprised of four microbial compartments and a higher plant compartment integrated in a closed loop. Each compartment is studied, designed and demonstrated at laboratory scale before being scaled-up for subsequent integration into the MELISSA Pilot Plant (MPP) at the Universitat Aut`noma de Barcelona. Work related to higher plant cultivation systems, o which have been historically focussed at the University of Guelph's Controlled Environment Systems Research Facility (CESRF), has included design of the HPC for the MPP, the metabolic characterization of MELiSSA candidate crops and the validation of theoretical gas exchange and nutrient dynamic models, The presented paper will review some of the recent data and HPC design work of CESRF conducted as part of Canada's involvement in the MELiSSA program and its partnership in the development of the MPP terrestrial demonstration test-bed.

  16. Production characteristics of lettuce Lactuca sativa L. in the frame of the first crop tests in the Higher Plant Chamber integrated into the MELiSSA Pilot Plant (United States)

    Tikhomirova, Natalia; Lawson, Jamie; Stasiak, Michael; Dixon, Mike; Paille, Christel; Peiro, Enrique; Fossen, Arnaud; Godia, Francesc

    Micro-Ecological Life Support System Alternative (MELiSSA) is an artificial closed ecosystem that is considered a tool for the development of a bioregenerative life support system for manned space missions. One of the five compartments of MELiSSA loop -Higher Plant Chamber was recently integrated into the MELiSSA Pilot Plant facility at Universitat Aut`noma deo Barcelona. The main contributions expected by integration of this photosynthetic compartment are oxygen, water, vegetable food production and CO2 consumption. Production characteristics of Lactuca sativa L., as a MELiSSA candidate crop, were investigated in this work in the first crop experiments in the MELiSSA Pilot Plant facility. The plants were grown in batch culture and totaled 100 plants with a growing area 5 m long and 1 m wide in a sealed controlled environment. Several replicates of the experiments were carried out with varying duration. It was shown that after 46 days of lettuce cultivation dry edible biomass averaged 27, 2 g per plant. However accumulation of oxygen in the chamber, which required purging of the chamber, and decrease in the food value of the plants was observed. Reducing the duration of the tests allowed uninterrupted test without opening the system and also allowed estimation of the crop's carbon balance. Results of productivity, tissue composition, nutrient uptake and canopy photosynthesis of lettuce regardless of test duration are discussed in the paper.

  17. Base or nucleophile? DFT finally elucidates the origin of the selectivity between the competitive reactions triggered by MeLi or LDA on propanal. (United States)

    Marchois, J; Fressigné, C; Lecachey, B; Maddaluno, J


    The competition between basicity and nucleophilicity of two standard organolithium reagents was studied using DFT. Comparing the reactivity of solvated (MeLi)2 and (LDA)2 toward propanal finally explains why methyllithium adds onto the carbonyl while LDA deprotonates the α-position, in accord with experiment and Ireland's deprotonation TS.

  18. Bartomeu Meliá (coord.), Otras historias de la Independencia, Asunción, Taurus, 2011, 177 p.



    La celebración del bicentenario de la independencia en el Paraguay se inscribe, quizás algo paradójicamente, en el marco más amplio de los festejos regionales relativos al mismo tema, poniendo de manifiesto pero – en la vuelta de tuerca de un mismo movimiento – también eludiendo la pregunta sobre la actualidad de la independencia en el país. En el prólogo del libro que coordina, Bartomeu Meliá plantea esta cuestión para introducir luego siete artículos breves que intentan dar cuenta de la ind...

  19. Effects of the Extraterrestrial Environment on Plants: Recommendations for Future Space Experiments for the MELiSSA Higher Plant Compartment. (United States)

    Wolff, Silje A; Coelho, Liz H; Karoliussen, Irene; Jost, Ann-Iren Kittang


    Due to logistical challenges, long-term human space exploration missions require a life support system capable of regenerating all the essentials for survival. Higher plants can be utilized to provide a continuous supply of fresh food, atmosphere revitalization, and clean water for humans. Plants can adapt to extreme environments on Earth, and model plants have been shown to grow and develop through a full life cycle in microgravity. However, more knowledge about the long term effects of the extraterrestrial environment on plant growth and development is necessary. The European Space Agency (ESA) has developed the Micro-Ecological Life Support System Alternative (MELiSSA) program to develop a closed regenerative life support system, based on micro-organisms and higher plant processes, with continuous recycling of resources. In this context, a literature review to analyze the impact of the space environments on higher plants, with focus on gravity levels, magnetic fields and radiation, has been performed. This communication presents a roadmap giving directions for future scientific activities within space plant cultivation. The roadmap aims to identify the research activities required before higher plants can be included in regenerative life support systems in space.

  20. Effects of the Extraterrestrial Environment on Plants: Recommendations for Future Space Experiments for the MELiSSA Higher Plant Compartment

    Directory of Open Access Journals (Sweden)

    Silje A. Wolff


    Full Text Available Due to logistical challenges, long-term human space exploration missions require a life support system capable of regenerating all the essentials for survival. Higher plants can be utilized to provide a continuous supply of fresh food, atmosphere revitalization, and clean water for humans. Plants can adapt to extreme environments on Earth, and model plants have been shown to grow and develop through a full life cycle in microgravity. However, more knowledge about the long term effects of the extraterrestrial environment on plant growth and development is necessary. The European Space Agency (ESA has developed the Micro-Ecological Life Support System Alternative (MELiSSA program to develop a closed regenerative life support system, based on micro-organisms and higher plant processes, with continuous recycling of resources. In this context, a literature review to analyze the impact of the space environments on higher plants, with focus on gravity levels, magnetic fields and radiation, has been performed. This communication presents a roadmap giving directions for future scientific activities within space plant cultivation. The roadmap aims to identify the research activities required before higher plants can be included in regenerative life support systems in space.

  1. Evidence for a role of the host-specific flea (Paraceras melis in the transmission of Trypanosoma (Megatrypanum pestanai to the European badger.

    Directory of Open Access Journals (Sweden)

    Regina Lizundia

    Full Text Available We investigated the epidemiology of Trypanosoma pestanai infection in European badgers (Meles meles from Wytham Woods (Oxfordshire, UK to determine prevalence rates and to identify the arthropod vector responsible for transmission. A total of 245 badger blood samples was collected during September and November 2009 and examined by PCR using primers derived from the 18S rRNA of T. pestanai. The parasite was detected in blood from 31% of individuals tested. T. pestanai was isolated from primary cultures of Wytham badger peripheral blood mononuclear cells and propagated continually in vitro. This population was compared with cultures of two geographically distinct isolates of the parasite by amplified fragment length polymorphism (AFLP and PCR analysis of 18S rDNA and ITS1 sequences. High levels of genotypic polymorphism were observed between the isolates. PCR analysis of badger fleas (Paraceras melis collected from infected individuals at Wytham indicated the presence of T. pestanai and this was confirmed by examination of dissected specimens. Wet smears and Giemsa-stained preparations from dissected fleas revealed large numbers of trypanosome-like forms in the hindgut, some of which were undergoing binary fission. We conclude that P. melis is the primary vector of T. pestanai in European badgers.

  2. Strategic implications of corporate social responsibility in hotel industry: A comparative research between NH Hotels and Meliá Hotels International

    Directory of Open Access Journals (Sweden)

    Marina Mattera


    Full Text Available The hospitality industry serves millions of people globally and is a multibillion-dollar industry with a significant growth expectation in the upcoming years. The Spanish tourism industry is one of the most developed sectors of the nation, being one of the main contributors to the country’s GDP. On a world wide scale, and specifically in the European context, there is a rising awareness for firms’ actions to be responsible towards the environment and the community in which they operate. Based on “triple bottom line” guidelines, companies’ mission in such a context is achieving competitive advantage by means of a business model considering three key aspects: people, profit, and planet. Considering the hospitality industry’s characteristics, it becomes essential to fulfill these new requirements to achieve sustainable competitive advantages. This exploratory study will outline which are the best practices of two main Spanish hotel corporations: NH Hotels and Meliá Hotels International. By pointing out actions undertaken by the most important firms of the sector, they can serve as an example and be replicated by other firms, thus increasing sustainability practices, improving understanding of triple bottom line, minimizing negative social as well as environmental footprint, and enhancing positive firms’ impacts in their operating contexts. DOI: 10.18870/hlrc.v2i4.85

  3. Microbial ecology of the closed artificial ecosystem MELiSSA (Micro-Ecological Life Support System Alternative): reinventing and compartmentalizing the Earth's food and oxygen regeneration system for long-haul space exploration missions. (United States)

    Hendrickx, Larissa; De Wever, Heleen; Hermans, Veronik; Mastroleo, Felice; Morin, Nicolas; Wilmotte, Annick; Janssen, Paul; Mergeay, Max


    MELiSSA is a bioregenerative life support system designed by the European Space Agency (ESA) for the complete recycling of gas, liquid and solid wastes during long distance space exploration. The system uses the combined activity of different living organisms: microbial cultures in bioreactors, a plant compartment and a human crew. In this minireview, the development of a short-cut ecological system for the biotransformation of organic waste is discussed from a microorganism's perspective. The artificial ecological model--still in full development--that is inspired by Earth's own geomicrobiological ecosystem serves as an ideal study object on microbial ecology and will become an indispensable travel companion in manned space exploration.

  4. Questionando culturas e identidades, utopias e fatalidades: Reflexões de um sociólogo na solidão do quarto n.o 514 de um Meliá Confort

    Directory of Open Access Journals (Sweden)

    José Machado Pais


    Full Text Available Na solidão do quarto de um Meliá Confort, um sociólogo frustrado debate-se com um stress de ansiedade provocado pela responsabilidade de ter de comentar dois volumes de uma vultuosa obra. Desapontado com os apontamentos que alinhavara, decide refazer a comunicação inspirando-se no hic et nunc do seu descontentamento. Levado por uma curiosidade espontânea, o nosso sociólogo parte das contingências e banalidades do quotidiano para chegar a um mundo de significações, através de mediações entre o particular e o global, o individual e o colectivo, o subjectivo e o objectivo. O mundo (vivido que o rodeia parece desvendar-se, num espectro de culturas e de identidades, a partir do momento em que é sociologicamente problematizado (concebido. É possível desvelar o social através das imediaticidades do quotidiano? Pode ser que sim, pode ser que não. Tudo depende dos questionamentos sociológicos, capazes ou não de o recapturarem na sua aparente factilidade que é dada pelos traços epidérmicos da quotidianeidade.

  5. Efeito de extratos aquosos de meliáceas sobre Bemisia tabaci biótipo B em tomateiro Effect of aqueous extracts of meliaceous plants on Bemisia tabaci B biotype on tomato plants

    Directory of Open Access Journals (Sweden)



    Full Text Available Comparou-se a bioatividade de extratos aquosos a 3% (p/v de três meliáceas, Melia azedarach L. (frutos verdes, Trichilia pallida Swartz (ramos e Azadirachta indica A. Juss (sementes, em relação à mosca branca Bemisia tabaci (Gennadius biótipo B, criada em tomateiro. No primeiro experimento os extratos foram aplicados sobre ovos e sobre ninfas com três dias de idade, avaliando-se a mortalidade e a duração das fases de ovo e de ninfa. No segundo experimento os extratos foram aplicados apenas sobre as ninfas, avaliando-se a mortalidade nessa fase e a longevidade e fecundidade dos adultos. Em relação à fase de ovo, o extrato de T. pallida foi o que provocou maior mortalidade, seguindo-se os de A. indica e M. azedarach. A maior mortalidade ninfal foi constatada com o extrato de A. indica, seguindo-se os de T. pallida e M. azedarach. Nenhum dos extratos afetou a duração das fases de ovo e de ninfa, assim como a longevidade e fecundidade.The objective of this research was to compare the effect of aqueous extracts of fresh fruits of Melia azedarach L., twigs of Trichilia pallida Swartz and seeds of zadirachta indica A. Juss, on eggs and nymphs of silverleaf whitefly Bemisia tabaci (Gennadius B biotype reared on tomato plants. The extracts were tested at a concentration of 3%. In the first experiment, the extracts were applied on eggs and 3-day-old nymphs. Records were taken on mortality, duration of egg and nymphal stages. In the second experiment the extracts were applied on 3-day-old nymphs and records were taken on nymphal mortality, adult longevity and fecundity. The extracts of T. pallida were the most effective on eggs, followed by A. indica and M. azedarach. The extracts of A. indica were the most effective on nymphs followed by T. pallida and M. azedarach. In both experiments, the duration of egg and nymph stages, longevity and fecundity were not affected by the extracts.

  6. Kayıp verilerin varlığında çoktan seçmeli testlerde madde ve test parametrelerinin kestirilmesi: SBS örneği [Item and test parameters estimations for multiple choice tests in the presence of missing data: The case of SBS

    Directory of Open Access Journals (Sweden)

    Ergül DEMİR


    Full Text Available Bu çalışmada, kayıp verilerin varlığında, çoktan seçmeli testlerde, farklı kayıp veri yöntemleri kullanılarak kestirilen madde ve test parametreleri arasındaki ilişkilerin incelenmesi ve bu tür testlerde kullanılması uygun olan kayıp veri yöntemlerinin belirlenmesi amaçlanmıştır. Temel araştırma türünde, ilişkisel tarama modelinde bir araştırma olarak tasarlanan bu çalışmada, analizler 527517 yanıtlayıcıya yönelik SBS (Seviye Belirleme Sınavı 2011 Matematik Testi A Kitapçığı verileri üzerinde yürütülmüştür. Veri analizlerinde silmeye dayalı yöntemlerden ‘dizin silme yöntemi’, basit atama yöntemlerinden ‘0 atama’, ‘seri ortalamaları ataması’, ‘gözlem birimi ortalaması ataması’, ‘yakın noktalar ortalama ataması’, ‘yakın noktalar medyan ataması’, ‘doğrusal interpolasyon’ ve ‘dorusal eğilim noktası ataması’ yöntemleri, en çok olabilirlik yöntemlerinden ‘regresyon atama’, ‘beklenti-maksimizasyon algoritması’ ve ‘veri çoğaltma’ yöntemleri, çoklu veri atama yöntemlerinden ise ‘Markov zincirleri Monte Carlo’ yöntemi olmak üzere 12 farklı kayıp veri yöntemi kullanılmıştır. Elde edilen bulgular, kayıp verilerin ihmal edilebilir olmaması durumunda çoktan seçmeli testlere yönelik istatistiksel kestirimlerde, uygun bir kayıp veri yönteminin kullanılmasının gerekli olduğunu göstermektedir. Silmeye dayalı yöntemler ve 0 Atama yöntemi, bu tür veriler için uygun yöntemler değildir. Basit atama yöntemlerinin ise yanlı kestirimler üretme olasılığı yüksektir. En çok olabilirlik ve çoklu veri atama yöntemleri, bu tür verilerde kullanılması en uygun kayıp veri yöntemleri olarak değerlendirilmektedir.

  7. Meli moli轻奢有无限可能

    Institute of Scientific and Technical Information of China (English)




  8. Effects of the Extraterrestrial Environment on Plants: Recommendations for Future Space Experiments for the MELiSSA Higher Plant Compartment


    Silje A. Wolff; Coelho, Liz H.; Irene Karoliussen; Ann-Iren Kittang Jost


    Due to logistical challenges, long-term human space exploration missions require a life support system capable of regenerating all the essentials for survival. Higher plants can be utilized to provide a continuous supply of fresh food, atmosphere revitalization, and clean water for humans. Plants can adapt to extreme environments on Earth, and model plants have been shown to grow and develop through a full life cycle in microgravity. However, more knowledge about the long term effects of the ...

  9. Çoktan Seçmeli Testlerde Kayıp Veri Sorunu: SBS Örneği

    Directory of Open Access Journals (Sweden)

    Ergül DEMİR


    Full Text Available In this study, it’s aimed that situations and variables related with probabiltiy of missing values in multiplechoice tests. Type of this study is basic research and model of this study is exploratory qualitative research. In the SBS 2011 math test, 7 items were determined as ‘risky’ item considering the amount of missing data and missing data pattern and mechanism. These items were evaluated with detail by 13 experts working in the field of mathematics and measurement and evaluation. In the taking of expert opinion, feedback-form was used. In the form, there were 7 items defined as ‘risky’ item and basic descriptive statistics for each items and the distribution of responses were given choices. It was asked by the experts that they should evaluate each items according to feedback-form. These reviews and opinions were classified and analyzed as descriptively and thematically . According to expert opinions, missing data occur primarily depends on psychometric properties and qualification of the measurement instrument. Observing individual behavior which leads the missing value is difficult in measuring instruments which contains psychometrically problematic.

  10. 上海哈瓦那大酒店空调系统设计%Air conditioning system design for Gran Meliá Shanghai Hotel

    Institute of Scientific and Technical Information of China (English)

    潘涛; 张智力; 钱必华; 苏生



  11. Strategic Implications of Corporate Social Responsibility in Hotel Industry: A Comparative Research between NH Hotels and Meliá Hotels International (United States)

    Mattera, Marina; Moreno-Melgarejo, Alberto


    The hospitality industry serves millions of people globally and is a multibillion-dollar industry with a significant growth expectation in the upcoming years. The Spanish tourism industry is one of the most developed sectors of the nation, being one of the main contributors to the country's GDP. On a world wide scale, and specifically in the…

  12. Krytyka nowoczesnych stosunków społecznych jako podstawa ponowoczesnej sztuki życia – egzystencjalny wymiar dzieła Michela Foucault [The Critique of Modern Social Relations as the Foundation of the Postmodern Art of Life – the Existential Dimension of the Work of Michel Foucault

    Directory of Open Access Journals (Sweden)

    Markus Lipowicz


    Full Text Available The aim of the present article is to reveal the essential connection of MichelFoucault’s critical attitude regarding social relationships with the formation of thepostmodern ethos of making out of the human life an artwork. It will be shown thatthe main object of Foucault’s critique are the relations of power and knowledge inthe Christian priesthood and their modern transformation in nonreligious institutions.From this point of view, mainly based on the philosophy of Friedrich Nietzsche,the Christian ethics occur to be an accumulation of techniques of disciplinizationand normalization. This attitude towards Christianity and modernity leads to thepostmodern ethos of making out of life an artwork. This notion is mainly based onthe antique Greek and Roman philosophy, where instead of obeying to universalethical principles the human being struggled to be his own master. Therefore thepostmodern existence tries to be beyond all traditional boundaries, which resultsin the danger of neglecting the historical fact, that Christianity was and still is animportant institution of the Western Civilization.

  13. Atividade ovicida de extratos aquosos de meliáceas sobre a mosca branca Bemisia tabaci (Gennadius biótipo B em tomateiro Ovicidal activity of aqueous extracts of meliaceae on the silverleaf whitefly for tomato

    Directory of Open Access Journals (Sweden)

    Antonio Pancrácio de Souza


    Full Text Available A mosca branca Bemisia tabaci (Gennadius biótipo B atualmente é uma das principais pragas do tomateiro. O uso de extratos botânicos no controle desse inseto é uma alternativa promissora, mas que ainda precisa ser melhor pesquisada. O presente trabalho teve como objetivo determinar a bioatividade de extratos aquosos de folhas de Melia azedarach L. e de ramos de Trichilia pallida Swartz, sobre a mosca branca Bemisia tabaci (Gennadius biótipo B, criada em tomateiro. Foram realizados dois experimentos, avaliando-se a mortalidade e duração das fases de ovo e ninfa, após o tratamento da fase de ovo com os referidos extratos. No primeiro experimento, foram testadas as concentrações de 1 e 2% (p/v, acrescentando-se a concentração de 3% no segundo experimento. Em todos os tratamentos houve efeito ovicida, sendo o maior valor obtido com T. pallida a 3% (52,32%. Nos demais tratamentos, a mortalidade variou entre 16 e 37%. Os extratos aplicados sobre os ovos pouco afetaram a sobrevivência ninfal. Com exceção do tratamento com T. pallida a 2%, no primeiro experimento, em que a mortalidade ninfal foi de 26,42%, nos demais a mortalidade foi inferior a 16%. Em nenhum dos experimentos foi verificada alteração na duração dos períodos de incubação e ninfal.The silverleaf whitefly is today one of most important pests of tomato. The use of botanical extracts to control this insect is an interesting technique, but more research about it should be carried out. The objective of this work was to determine the bioactivity of aqueous extracts of Melia azedarach leaves and Trichilia pallida twigs on the silverleaf whitefly Bemisia tabaci (Gennadius biotype B, reared on tomato. Extracts were applied to eggs, and mortality and duration of egg and nymphal stages were evaluated in two experiments. In the first experiment, extracts were tested at concentrations of 1 and 2% (w/v and in the second experiment the concentration of 3% was added. The ovicidal effect was observed in all treatments. The highest value was obtained with the extract of T. pallida at 3% (52.32%. For the other treatments the mortality ranged between 16 and 37%. The extracts applied on eggs presented low effect on nymphs. With exception of T. pallida at 2%, in the first experiment, where the nymphal mortality was 26.42%, in the other treatments the values were lower than 16%. The duration of egg and nymph periods were not affected by the extracts.

  14. Optimal management of nail disease in patients with psoriasis


    Piraccini BM; Starace M


    Bianca Maria Piraccini, Michela Starace Division of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy Abstract: Psoriasis is a common skin disease, with nail involvement in approximately 80% of patients. Nail psoriasis is often associated with psoriatic arthropathy. Involvement of the nails does not always have relationship with the type, gravity, extension, or duration of skin psoriasis. Nail psoriasis can occur at any age and ...

  15. Dissolved oxygen, salinity, and temperature data from multiple ships using CTD casts in the South Pacific Ocean from 26 March 1985 to 19 December 1997 (NODC Accession 0000286) (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Dissolved oxygen, salinity, and temperature data were collected from the ALMIRANTE MONTT, CARLOS PORTE, SANTA MARGARITA II, MELI PULLI, IZISHI MARU, STELLA MARIS,...

  16. A time series study on the effects of heat on mortality and evaluation of heterogeneity into European and Eastern-Southern Mediterranean cities: results of EU CIRCE project


    Dörbudak, Zeynep; Leone, Michela; D'Ippoliti, Daniela; De Sario, Manuela; Analitis, Antonis; Menne, Bettina; Katsouyanni, Klea; de'Donato, Francesca K.; Basagana, Xavier; Ben Salah, Afif; Casimiro, Elsa; Iniguez, Carmen; Peretz, Chava; Wolf, Tanja; Michelozzi, Paola


    RESEARCH Open Access A time series study on the effects of heat on mortality and evaluation of heterogeneity into European and Eastern-Southern Mediterranean cities: results of EU CIRCE project Michela Leone1*, Daniela D’Ippoliti1, Manuela De Sario1, Antonis Analitis2, Bettina Menne3, Klea Katsouyanni2, Francesca K de’ Donato1, Xavier Basagana4,5,6, Afif Ben Salah7, Elsa Casimiro8, Zeynep Dörtbudak9, Carmen Iñiguez4,10,11, Chava Peretz12, Tanja Wolf3 and Paola Michelozzi1...

  17. The Sardinian Literary Spring: An Overview. A New Perspective on Italian Literature

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    Michele Broccia


    Full Text Available This article aims at presenting today’s Sardinian literary scene and how some novelists (Sergio Atzeni, Giulio Angioni, Salvatore Mannuzzu, Salvatore Niffoi, Marcello Fois, Giorgio Todde, Milena Agus, Francesco Abate, Flavio Soriga and Michela Murgia, during the last few decades, drawing their narrative subjects directly from the regional and local culture, are contributing to a new development in Italian literature. These authors’ novels often contain references to Sardinian linguistic, social, anthropological and historical facts. Their success has led literary critics to talk about a Sardinian Literary Spring or Sardinian Nouvelle Vague, i.e. a literary phenomenon, which is the expression of a deep-rooted Sardinian identity.

  18. Genome Sequence of the Edible Cyanobacterium Arthrospira sp. PCC 8005▿


    Janssen, P. J.; Morin, N.; Mergeay, M; Leroy, B.; Wattiez, R; Vallaeys, T.; Waleron, K.; Waleron, M.; Wilmotte, A.; Quillardet, P; de Marsac, N. Tandeau; Talla, E.; Zhang, C.-C.; Leys, N.


    We determined the genome sequence of Arthrospira sp. PCC 8005, a cyanobacterial strain of great interest to the European Space Agency for its nutritive value and oxygenic properties in the Micro-Ecological Life Support System Alternative (MELiSSA) biological life support system for long-term manned missions into space.

  19. Dicty_cDB: Contig-U00742-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ORKING DRAFT SEQU... 38 5.5 5 ( CR855214 ) Oryza sativa genomic DNA, chromosome 4, BAC clone... 36 5.5 5 ( AF338937 ) Lycaeides isolate J3 control region, part... 32 5.5 3 ( AY68943


    NARCIS (Netherlands)

    TANDON, VK; AGARWAL, [No Value; van Leusen, A.M.


    S-(+)-3-Hydroxytetrahydrofuran (1) on reaction with phenylglyoxallyl chloride (2) forms S-(+)-3-tetrahydrofuranyl benzoyformate (3) in 88% yield. Further reaction of the alpha-ketoester 3 with MeLi at - 95 degrees C followed by basic hydrolysis results in asymmetric synthesis of S-(+)-atrolactic aci

  1. Phenology of blue cactus moth Melitara prodenialis (Lepidoptera: Pyralidae) (United States)

    Native cactus plants (Opuntia stricta Haw. [Cactaceae]) were sampled weekly at St. Marks National Wildlife Refuge, St. Marks, Florida (30.16 - 30° 1' N, -84.21 - 84° 1' W) from September 2006 to September 2007 for the native blue cactus moth, Melitara prodenialis Walker (Lepidoptera: Pyralidae) Meli...

  2. Metabolic Effect Level Index Links Multivariate Metabolic Fingerprints to Ecotoxicological Effect Assessment. (United States)

    Riedl, Janet; Schreiber, René; Otto, Matthias; Heilmeier, Hermann; Altenburger, Rolf; Schmitt-Jansen, Mechthild


    A major goal of ecotoxicology is the prediction of adverse outcomes for populations from sensitive and early physiological responses. A snapshot of the physiological state of an organism can be provided by metabolic fingerprints. However, to inform chemical risk assessment, multivariate metabolic fingerprints need to be converted to readable end points suitable for effect estimation and comparison. The concentration- and time-dependent responsiveness of metabolic fingerprints to the PS-II inhibitor isoproturon was investigated by use of a Myriophyllum spicatum bioassay. Hydrophilic and lipophilic leaf extracts were analyzed with gas chromatography-mass spectrometry (GC-MS) and preprocessed with XCMS. Metabolic changes were aggregated in the quantitative metabolic effect level index (MELI), allowing effect estimation from Hill-based concentration-response models. Hereby, the most sensitive response on the concentration scale was revealed by the hydrophilic MELI, followed by photosynthetic efficiency and, 1 order of magnitude higher, by the lipophilic MELI and shoot length change. In the hydrophilic MELI, 50% change compares to 30% inhibition of photosynthetic efficiency and 10% inhibition of dry weight change, indicating effect development on different response levels. In conclusion, aggregated metabolic fingerprints provide quantitative estimates and span a broad response spectrum, potentially valuable for establishing adverse outcome pathways of chemicals in environmental risk assessment.

  3. Pengaruh Hardiness terhadap Employee Engagement pada PNS Kementerian Pekerjaan Umum




    131301101 Employee engagement merupakan keadaan positif yang muncul bersama terkait dengan pekerjaan yang berhubungan dengan kesejahteraan yang ditandai dengan vigour, dedication, dan absorption. Salah satu faktor untuk mempengaruhi employee engagement adalah kepribadian, hardiness. Hardiness terdiri dari commitment, control,dan challenge dinilai sebagai salah satu bentuk kepribadian yang baik saat menghadapi keadaan yang penuh tekanan atau sumber stres. Penelitian ini dilakukan untuk meli...

  4. Análisis de dos cadenas hoteleras. Un estudio comparativo de Nh Hoteles y Melia Hotels International



    Dentro del marco conceptual, el estudio de las empresas NH Hoteles y Meliá se divide en tres apartados:  Un examen teórico sobre el sector turístico y hotelero, así como la evolución histórica de los mismos y su influencia en la economía española.  Un análisis interno de las compañías NH y Meliá, donde se abordan diferentes apartados sobre su historia, oferta hotelera, formas de explotación, marcas, formas de distribución, estructura jurídica y organización empresarial.  Un anális...

  5. Machine Learning wins the Higgs Challenge

    CERN Multimedia

    Abha Eli Phoboo


    The winner of the four-month-long Higgs Machine Learning Challenge, launched on 12 May, is Gábor Melis from Hungary, followed closely by Tim Salimans from the Netherlands and Pierre Courtiol from France. The challenge explored the potential of advanced machine learning methods to improve the significance of the Higgs discovery.   Winners of the Higgs Machine Learning Challenge: Gábor Melis and Tim Salimans (top row), Tianqi Chen and Tong He (bottom row). Participants in the Higgs Machine Learning Challenge were tasked with developing an algorithm to improve the detection of Higgs boson signal events decaying into two tau particles in a sample of simulated ATLAS data* that contains few signal and a majority of non-Higgs boson “background” events. No knowledge of particle physics was required for the challenge but skills in machine learning - the training of computers to recognise patterns in data – were essential. The Challenge, hosted by Ka...

  6. North Spain (Burgos wild mammals ectoparasites

    Directory of Open Access Journals (Sweden)

    Domínguez G.


    Full Text Available Twenty-seven species of arthropods were collected from 105 wild mammals, six wolves Canis lupus (Linnaeus, 1758 included. A total of 87 animals (82,8 % harboured some ectoparasites. Ticks were found in 60 % of the samples, fleas in 51.4 %, chewing-lice in 3.8 %, and others (Mesostigmata and hippoboscids in 3.8 %. Moreover, 42.5 % were single infestation and 57.5 % mixed. Some of the species were new records for a host in spanish country such as Trichodectes canis (De Géer, 1778, Ixodes trianguliceps (Birula, 1895, Ceralophyllus (Monopsyllus S. sciurorum (Schrank, 1803 and Paraceras melis melis (Walker, 1856 on several mammals. Two species were new records for Spain: Chaetopsylla matina (Jordan, 1925 and Archaeopsylla erinacei erinacei (Bouché, 1835.

  7. The Invention of "The Invention of Hugo Cabret" (United States)

    Selznick, Brian


    "The Invention of Hugo Cabret" is a story about Georges Melies that the author began thinking about over 15 years ago and took about two-and-a-half years to complete. The book is about a boy named Hugo Cabret, an orphan living secretly in the walls of a train station in Paris who becomes involved in a mystery that ties him together with a mean old…

  8. Proteome-Wide Analysis and Diel Proteomic Profiling of the Cyanobacterium Arthrospira platensis PCC 8005



    The filamentous cyanobacterium Arthrospira platensis has a long history of use as a food supply and it has been used by the European Space Agency in the MELiSSA project, an artificial microecosystem which supports life during long-term manned space missions. This study assesses progress in the field of cyanobacterial shotgun proteomics and light/dark diurnal cycles by focusing on Arthrospira platensis. Several fractionation workflows including gel-free and gel-based protein/peptide fractionat...

  9. The Invention of "The Invention of Hugo Cabret" (United States)

    Selznick, Brian


    "The Invention of Hugo Cabret" is a story about Georges Melies that the author began thinking about over 15 years ago and took about two-and-a-half years to complete. The book is about a boy named Hugo Cabret, an orphan living secretly in the walls of a train station in Paris who becomes involved in a mystery that ties him together with a mean old…

  10. Neutral and cationic vanadium(III) alkyl and allyl complexes with a cyclopentadienyl-amine ancillary ligand

    NARCIS (Netherlands)

    Liu, GH; Beetstra, DJ; Meetsma, A; Hessen, B; Liu, Guohua; Beetstra, Dirk J.


    The (N,N-dimethylaminoethyl)cyclopentadienyI vanadium(III) complex [eta(5),eta(1)-C5H4(CH2)(2)-NMe2]VCl2(PMe3) (1), in which the pendant amine is coordinated to the metal center, was prepared by the reaction Of VCl3(PMe3)(2) with Li[C5H4(CH2)(2)NMe2] in THF. Reaction of 1 with 2 equiv of MeLi yields

  11. Effects of Opsonization and Gamma Interferon on Growth of Brucella Melitensis 16M in Mouse Peritoneal Macrophages In Vitro (United States)


    SUBTITLE Effects of Opsonization and Gamma Interferon on Growth of Brucella , melitensis 16M in Mouse Peritoneal Microphages rom In Vitro 3. REPORT...with Brucella melitensis 16M treated with complement- and/or antibody-rich serum. Mouse serum rich in antibody against Brucella lipopolysaccnaride...pathogens of humans and livestock. Brucella meli- tensis usually infects sheep, goats , and camels and is the most pathogenic species for humans (1). Like

  12. Transparens inom PR-verksamhet : En studie om PR-företagens förhållanden till öppenhet


    Ehrs, Olof


    Abstract Title: Transparency within Public Relations – A study about PR-companies understanding of openness Pages: 71 Authors: Olof Ehrs Tutor: Virginia Melián Course: Media and Communication Studies, Bachelor Degree. Period: Autumn 2011. University: The Department of Journalism, Media and Communication, JMK,at Stockholm University. Background and aim: The PR-industry is continuing to grow in Sweden. The increase of working consultancies has made it more difficult to define what PR-activities...

  13. General and Robust Strategies for Multifunctional Organic-Inorganic Nanocompositesvia Direct Growth of Monodisperse Nanocrystals Intimately and Permanently Connected with Polymers (United States)


    amphiphilic copolymer brushes: Poly( ethylene oxide )-graft-polystyrene. J. Polym. Sci. Part A: Polym. Chem. 44, 4361-4371 (2006). 2. Mora-Pale, M., Meli, L...results are summarized as follows. Recent research has witnessed tremendous advances in isotropic nanomaterials synthesis , which has provided access...nanocrystals of both fundamental and practical interest.(12, 13) Current emerging synthesis approaches, including template-assisted synthesis ,(14-16

  14. Standardization of Experimental Design for Crop Cultivation in Life Support Systems for Space Exploration (United States)

    Wolff, Silje Aase; Coelho, Liz Helena; Karoliussen, Irene; Kittang Jost, Ann-Iren

    Due to logistical challenges, long-term human space exploration missions require a life support system capable of regenerating all the essentials for survival. Higher plants can be utilized to provide a continuous supply of fresh food, fresh air, and clean water for humans. The extensive work performed have shown that higher plants are able to adapt to space conditions in low Earth orbit, at least from one generation from seed to seed. Since the hardware has turned out to be of great importance for the results in microgravity research, full environmental monitoring and control must be the standard for future experiments. Selecting a few model plants, including crop plants for life support, would further increase the comparability between studies. The European Space Agency (ESA) has developed the Micro-Ecological Life Support System Alternative (MELiSSA) program to develop a closed regenerative life support system, based on micro-organisms and higher plants, with continuous recycling of resources. In the present study, recommended standardization of the experimental design for future scientific work assessing the effects of graded gravity on plant metabolism will be presented. This includes the environmental conditions required for cultivation of the selected MEliSSA species (wheat, bread wheat, soybean and potato), as well as guidelines for sowing, plant handling and analysis. Keywords: microgravity; magnetic field; radiation; MELiSSA; Moon; Mars.

  15. Preliminary investigations of Spirulina effect on cancer cells: interest for long-term manned space missions (United States)

    Baatout, S.; Bekaert, S.; Hendrickx, L.; Derradji, H.; Mergeay, M.

    Background In view of long haul space exploration missions the development of regenerative life support systems is of crucial importance to increase the crew autonomy and decrease the cost associated to the mass embarked Therefore in the late 80 s the European Space Agency initiated the MELiSSA project Micro-Ecological Life Support System Alternative MELiSSA has been conceived as a micro-organisms and higher plant process enabling high recycling efficiency The cyanobacteria Arthrospira sp is occupying one of the MELiSSA compartments Its genome is now being sequenced and this will help to better understand or improve its food value as well as to have a look at its putative toxic potential Aim In this study we were interested in studying the threshold of intrinsic cytotoxic effects of Spirulina dry extract from Sigma containing washed and lyophilized mixed Arthrospira strains on human cancer cells and its cell type dependency Method For that purpose we used flow cytometry to estimate cell death apoptosis and necrosis in three human leukaemic cell lines HELA cervix carcinoma IM-9 multiple myeloma K562 chronic myelogenous leukaemia Cells were cultured in the presence of an aqueous extract of Spirulina concentrations ranging from 0 to 500 mu g ml for 15 to 40 hours Apoptosis and necrosis were evaluated by annexin-V-PI staining cell size and granularity Early apoptosis was monitored by analysing the maintenance of mitochondrial membrane potential DioC 6 3 and the

  16. Micropollutants in closed life-support systems: the case of triclosan, a biocide excreted via urine (United States)

    Mastroleo, Felice; Pycke, Benny; Boon, Nico; de Wever, Heleen; Hendrickx, Larissa; Mastroleo, Felice; Wattiez, Ruddy; Mergeay, Max; Verstraete, Willy

    OBJECTIVES: The impact of triclosan on the growth and physiology of the bacterium Rhodospirillum rubrum was studied in the frame of the regenerative life-support system, Micro- Ecological Life Support System Alternative (MELiSSA). A wide range of compounds, such as steroid hormones, pharmaceuticals and personal care products, might enter the life support system via the excrements that are to be treated and recycled. Triclosan was chosen as the first compound to be tested because MELiSSA is a closed system, which is consequently particularly sensitive to compounds inhibiting the microbial metabolism. Because triclosan is increasingly used as an antimicrobial biocide in hygienic formulations (such as toothpaste, mouthwash, deodorants, etc.) and due to its chemical stability, it is considered an emerging pollutant in terrestrial ecosystems. METHODS: In a first phase, the triclosan concentration expected in the life-support system was estimated, the Minimal Inhibitory Concentration (MIC) was determined via plating, and the effect on growth kinetics was assessed by comparing growth parameters in the Gompertz model. In a second phase, the secondary effects of triclosan on cell physiology and gene expression were studied through flow-cytometry and microarray analyses, respectively. RESULTS: Based on the pharmacokinetic data from literature, the predicted concentration range is estimated to be 6-25µg/L triclosan in the Rhodospirillum rubrum compartment of the MELiSSA. The minimal inhibitory concentration of triclosan was determined to be 71 µg/L after 7 days of exposure on Sistrom medium. Upon exposure to 50-200µg/L triclosan, triclosan-resistant mutants of Rhodospirillum rubrum arose spontaneously at high frequency (3.1 ∗ 10 - 4). Analysis of the growth kinetics of the wild-type revealed that triclosan causes an important elongation of the lag-phase and a decrease in growth rate. At concentrations higher than 75mg/L(LD = 500mg/L), triclosan is bactericidal to wild

  17. Advanced anaerobic bioconversion of lignocellulosic waste for the melissa life support system (United States)

    Lissens, G.; Verstraete, W.; Albrecht, T.; Brunner, G.; Creuly, C.; Dussap, G.; Kube, J.; Maerkl, H.; Lasseur, C.

    The feasibility of nearly-complete conversion of lignocellulosic waste (70% food crops, 20% faecal matter and 10% green algae) into biogas was investigated in the context of the MELiSSA loop (Micro-Ecological Life Support System Alternative). The treatment comprised a series of processes, i.e. a mesophilic laboratory scale CSTR (continuously stirred tank reactor), an upflow biofilm reactor, a fiber liquefaction reactor employing the rumen bacterium Fibrobacter succinogenes and a hydrothermolysis system in near-critical water. By the one-stage CSTR, a biogas yield of 75% with a specific biogas production of 0.37 l biogas g-1 VSS (volatile suspended solids) added at a RT (hydraulic retention time) of 20-25 d was obtained. Biogas yields could not be increased considerably at higher RT, indicating the depletion of readily available substrate after 25 d. The solids present in the CSTR-effluent were subsequently treated in two ways. Hydrothermal treatment (T ˜ 310-350C, p ˜ 240 bar) resulted in effective carbon liquefaction (50-60% without and 83% with carbon dioxide saturation) and complete sanitation of the residue. Application of the cellulolytic Fibrobacter succinogenes converted remaining cellulose contained in the CSTR-effluent into acetate and propionate mainly. Subsequent anaerobic digestion of the hydrothermolysis and the Fibrobacter hydrolysates allowed conversion of 48-60% and 30%, respectively. Thus, the total process yielded biogas corresponding with conversions up to 90% of the original organic matter. It appears that particularly mesophilic digestion in conjunction with hydrothermolysis offers interesting features for (nearly) the MELiSSA system. The described additional technologies show that complete and hygienic carbon and energy recovery from human waste within MELiSSA is technically feasible, provided that the extra energy needed for the thermal treatment is guaranteed.

  18. La tesis de Mariátegui sobre el carácter feudal de la economía colonial peruana Mariátegui's thesis on the feudal character of Peruvian colonial economy

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    David Sobrevilla


    Full Text Available José Carlos Mariátegui, en su "Esquema de la evolución económica" [del Perú], el primero de los 7 ensayos (1928, consideró que la economía colonial peruana era feudal. En nuestro libro El marxismo de Mariátegui y su aplicación a los '7 ensayos (2005', manifestamos que con la información disponible hoy, tal afirmación se había tornado insostenible. Por su parte, Antonio Melis señaló que la caracterización de Mariátegui podía ser discutida. En este artículo se examinan las observaciones planteadas por Melis. Se considera en primer lugar la posición de A. G. Frank, así como las reacciones que suscitó. Se exponen a continuación las razones en contra de la tesis de Mariátegui sobre el carácter feudal de la economía peruana colonial. Se examina luego la tesis de Ruggiero Romano sobre el feudalismo en general y sobre el iberoamericano en particular. Se realiza, por último, una consideración final.José Carlos Mariátegui, in his "Outline of economic evolution" [Peru], the first of the 7 ensayos (1928, considered Peru's colonial economy was feudal. In our book Mariátegui's Marxism and its application to '7 ensayos' (2005, we said that the information available today, such a claim had become untenable. For his part, Antonio Melis said Mariátegui's characterization could be discussed. This article discusses the observation raised by Melis. It considers the position of A. G. Frank, as well as the reactions to it. Then the reasons against Mariátegui's thesis are also considered. The thesis on feudalism in general and the Latin American one in particular is examined by Ruggiero Romano. A final one consideration is done as a conclusion.

  19. [Helminth findings in indigenous raccoon dogs Nyctereutes procyonoides (Gray, 1843)]. (United States)

    Thiess, A; Schuster, R; Nöckler, K; Mix, H


    Internal organs of 74 racoon dogs originating from the eastern districts of the Federal Land Brandenburg were subjected to a complete helminthological dissection. In addition, samples of diaphragma muscles from 46 further animals were examined for Trichinella larvae. Altogether 3 trematode- (Alaria alata, Isthmiophora melis, Metorchis bilis), 3 cestode- (Mesocestoides sp., Echinococcus multilocularis, Taenia polyacantha) and 7 nematode species (Capillaria aerophila, C. plica, Trichinella spiralis, Uncinaria stenocephala, Molineus patens, Crenosoma vulpis, Toxocara canis) could be identified. Thereby, the racoon dog has a comparable helminth spectrum as well known in red foxes. Differences in the frequency of the occurrence of helminths in both hosts can be explained by different food preferences.


    Institute of Scientific and Technical Information of China (English)


    Human cervical cancer is one of the most com-mon malignant neoplas m in women with a highdeath rate.It is characterized by a lot of factors andits pathological process is very complicated.In spiteof progress in the diagnosis and therapy of humancervical cancer,ti mely and accurate methods are ur-gently needed[1].Application of murine monoclonal antibodies(McAb)for the study of diagnosis and treat mentsfor human tumors is li mited by a number of fac-tors.Due to the progress in gene engineering andphage displ...

  1. Descripción matemática y simulación de sistemas de lodos activados para el tratamiento de aguas residuales


    Yamilé Martínez Ochoa; Agustín Benítez Hernández


    Se realiza la descripción matemática de la planta depuradora que brinda servicio a las instalaciones hoteleras del Complejo Turístico Sol-Meliá en Varadero. Basado en el esquema de tratamiento mediante lodos activados que opera en esta cadena hotelera, se desarrollan los modelos matemáticos que caracterizan a este proceso de depuración en estado estacionario, permitiendo simular mediante ordenadores el funcionamiento de esta instalación o de ot...

  2. Experimental and Theoretical Study on Cavitation Inception and Bubbly Flow Dynamics. Part 1. Design, Development and Operation of a Cavitation Susceptibility Meter. Part 2. Linearized Dynamics of Bubbly and Cavitating Flows with Bubble Dynamics Effects. (United States)


    want to express my deep gratitude to Prof. Rolf Sabersky, who was my temporary - but much caring - advisor during my first year, and to Prof. Renzo ...dielectric beamsplitter cube, MelIes Griot No. 03 BSC 015/079, 50.8 x 50.8 x 50.8mm, 2A flat, anti-reflection coated; " first piano -convex spherical glass...of the telescopic relay, Melles Griot No. 01 LPX 107/079, f = 50mmr, 4) = 20 rm, anti-reflection coated; * focusing and receiving piano -convex

  3. Reviews of recent publications

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    Full Text Available Edwards, Catherine, ed. Roman Presences: Receptions of Rome in European Culture, 1789-1945. Christina Ujma Gilman, Sander L. and Jurek Becker. A Life in Five Worlds. David Malcolm Rodden, John, ed. Conversations with Isabel Allende. Daniela Melis Schrift, Alan D., ed. Why Nietzsche Still? Reflections on Drama, Culture, and Politics. Jennifer Marston William Viegnes, Michel, ed. Hugo et la chimère. Recherches & Travaux 62. Kathryn M. Grossman Winston, Jane Bradley. Postcolonial Duras: Cultural Memory in Postwar France. Carol J. Murphy

  4. Side Notes on Three Lessons of Guido Calabresi

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    Guido Melis


    Full Text Available The essay offers some comments about three lectures given by the US Federal Judge Guido Calabresi in Macerata in 2012. The lessons relate to the organization of the federal courts in the United States, the form and the role of judicial decisions within a federal system and the considerations about the death penalty offered by a judge strongly contrary to it. According to Melis these lessons return in an extraordinarily vivid and precise way the structure of the judiciary system and at the same time the subjective experience of a judge.

  5. Building a new Rasch-based self-report inventory of depression

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    Balsamo M


    Full Text Available Michela Balsamo,1 Giuseppe Giampaglia,2 Aristide Saggino11DiSPUTer, Department of Psychological Sciences, Humanities and Territory, “G d'Annunzio” University, Chieti-Pescara, Italy; 2Department of Economics and Statistics, “Federico-II” University, Naples, ItalyAbstract: This paper illustrates a sequential item development process to create a new self-report instrument of depression refined with Rasch analysis from a larger pool of potential diagnostic items elicited through a consensus approach by clinical experts according to the latest edition of the Diagnostic and Statistical Manual of Mental Disorders criteria for major depression. A 51-item pool was administered to a sample of 529 subjects (300 healthy community-dwelling adults and 229 psychiatric outpatients. Item selection resulted in a 21-item set, named the Teate Depression Inventory, with an excellent Person Separation Index and no evidence of bias due to an item–trait interaction (χ2=147.71; df =168; P=0.48. Additional support for the unidimensionality, local independence, appropriateness of the response format, and discrimination ability between clinical and nonclinical subjects was provided. No substantial differential item functioning by sex was observed. The Teate Depression Inventory shows considerable promise as a unidimensional tool for the screening of depression. Finally, advantages and disadvantages of this methodology will be discussed in terms of subsequent possible mathematical analyses, statistical tests, and implications for clinical investigations.Keywords: depression, scale development, self-report scales, Rasch analysis

  6. Université de Genève

    CERN Multimedia


    Ecole de physique - Département de physique nucléaire et corspusculaire 24, quai Ernest-Ansermet 1211 GENÈVE 4 Tél: (022) 379 62 73 - Fax: (022) 379 69 92 Wednesday 17 décembre 2008 PARTICLE PHYSICS SEMINAR at 17.00 hrs – Stückelberg Auditorium Bent crystals: a long story and its new frontiers by Dr Michela Prest / Universita degli Studi dell’Insubria, sede di Como When a particle physicist hears the world "crystal", he usually thinks of calorimeters, silicon detectors, a state of matter. When he hears the word "magnet", he thinks of bulky, heavy objects. In 1976, E. H. Tsyganov experimentally demonstrated how a bent crystal 1 mm thick, a couple of mm wide and a few cm high can steer particles as a dipole of several tens of Tesla. Crystals and the channelling phenomena have been studied for around 30 years. Hadron beam collimation has been immediately identified as their main application and the understanding of the physics of crystals and their experimental stu...

  7. Mindful approach to University education

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    Broggi F


    Full Text Available Fiorenza Broggi,1 Monica Bomba,1 Michela Rimondini,2 Maura Mutti,1 Sara Pasta,1 Chiara Ricci,1 Luca Tagliabue,1 Silvia Valsecchi,1 Elide Monaco,1 Francesca Neri,1 Silvia Oggiano,2 Renata Nacinovich,1 1Department of Child and Adolescent Psychiatry, San Gerardo Hospital, University of Milano–Bicocca, Monza, 2Department of Clinical Psychology, University of Verona, Italy Abstract: A mindful approach to education and training could improve students’ reflective capacities and have positive effects on clinical practice because it facilitates a helping relationship. The main aims of this study were to investigate whether participation in a mindful-based University training was associated with increases in mindfulness skills as measured by the 5-Facet M Questionnaire, and to present the Italian validation of the questionnaire. Sixty-seven students from the course Neuro and Psychomotor Therapy were enrolled. They filled in the self-administered 5-Facet M Questionnaire before and 1 month after a mindfulness-based training, focused on role-playing and followed by a feedback group discussion. The Italian version of the 5-Facet M Questionnaire had good psychometric properties. The pre- and post-training analysis showed a significant increase in the subscale ‘Observing’. Findings suggest that role-playing and feedback group sessions are valid tools to improve students’ mindfulness skills. Keywords: mindfulness, role play, self-awareness, communication skills, insight, reflective capacities, feedback

  8. Decisional impairments in cocaine addiction, reward bias, and cortical oscillation “unbalance”

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    Balconi M


    Full Text Available Michela Balconi, Roberta Finocchiaro Research Unit in Affective and Social Neuroscience, Department of Psychology, Catholic University of the Sacred Heart, Milan, Italy Abstract: A vast amount of research has suggested that subjects with substance use disorder (SUD might have difficulty making advantageous decisions that opt in favor of a longer-term, larger reward than an immediate, smaller reward. The current research explored the impact of reward bias and cortical frontal asymmetry (left lateralization effect in SUD in response to a decisional task (Iowa Gambling Task. Fifty SUD participants and 40 controls (CG were tested using the Iowa Gambling Task. Electrophysiology (electroencephalography recording was performed during task execution. We measured left and right dorsolateral prefrontal cortex power activity. Behavioral responses (gain/loss options; frequency band modulation (asymmetry index for delta, theta, alpha, and beta band; and cortical source localization (standardized low-resolution brain electromagnetic tomography were considered. The SUD group opted in favor of the immediate reward option (loss more frequently than the long-term option (gain when compared to the CG. Secondly, SUD showed increased left-hemisphere activation in response to losing (with immediate reward choices in comparison with the CG. The left hemispheric unbalance effect and the “reward bias” were adduced to explain the decisional impairment in SUD. Keywords: drug addiction, cortical brain oscillations, left lateralization effect, reward mechanism, Iowa Gambling Task

  9. Determining a diagnostic cut-off on the Teate Depression Inventory

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    Balsamo M


    Full Text Available Michela Balsamo, Aristide SagginoDepartment of Psychological Sciences, Humanities and Territory, G. d’Annunzio University of Chieti-Pescara, Chieti, ItalyAbstract: A small but growing body of literature suggests that the Teate Depression ­Inventory (TDI may be an “objective” measure of depression compared with other commonly used scales. Furthermore, the TDI has strong psychometric properties in both clinical and nonclinical samples. The present study aimed to extend the use of TDI by identifying cut-off scores that could differentiate varying levels of depression severity in a group of clinically diagnosed depression disorder patients (N=125. Three receiver operating characteristic curve analyses indicated cut-off scores of 21 (sensitivity =0.86, specificity =0.94, and classification accuracy =0.90; 36 (sensitivity =0.84, specificity =0.96, and classification accuracy =0.92; and 50 (sensitivity =0.81, specificity =0.93, and classification accuracy =0.90, for minimal, mild, moderate, and severe depression, respectively. Results suggest that the TDI measures depression severity across a broad range with high test accuracy and may be appropriately used to screen for depression.Keywords: major depression, ROC curve, self-report scales, Rasch analysis, depression screening

  10. Design of a Regenerative Life Support System for a Moon Base. Preliminary Results. (United States)

    Duatis Juarez, Jordi; Guirado, Víctor; Lasseur, Christophe

    NTE-SENER has finalised a study under an ESA contract, to define a preliminary system design of an European Module to provide Environmental Control and Life Support to a potential Moon base. The design is based on current Life Support System technologies under development in Europe (MELiSSA, GWRU, Sabatier Reactor and UTU) along with contamination and microbial detection technologies (ANITA, MIDASS). The ECLSS is sized to provide water, air and up to the 40 As a support to the study a simulator has been developed to analyse the energy, volume and mass and the flow rates and efficiencies of the different components. The study applied the basics of the ALISSE criteria to evaluate the technologies taking as a source the results of the simulations. Detailed models of the different technologies have been developed including feedback from the pilot designs. The results of the study have showed up opportunities of improvement and many points that need to be further investigated. The technologies used in the study are based on the MELiSSA Pilot Plant reactors implementation and the results could affect their design in the near fu-ture in aspects such as carbon recycling, irrigation methods, energy consumption, technologies involved, etc.

  11. Insight into the radiotolerance of the life support bacterium Rhodospirillum rubrum S1H by means of phenotypic and transcriptomic methods (United States)

    Mastroleo, Felice; Monsieurs, Pieter; Leys, Natalie

    The MELiSSA life support system from the European Space Agency is targeting the produc-tion of oxygen, water and food by recycling organic waste. Among different types of pro-cesses, MELiSSA uses several interconnected bioreactors inhabited by microorganisms and higher plants (Hendrickx et al., 2006; Mergeay et al., 1988). Because this loop is foreseen to be functional in space where it will be exposed to higher doses and different spectra of ionizing radiation, it was decided to screen the radiotolerance of the organisms used. In this study, the radiotolerance (i.e. tolerance to ionizing radiation) of the photosynthetic bacterium Rho-dospirillum rubrum S1H was investigated. In this test, first the effect of low energy Cobalt-60 gamma rays, were tested. To assess the radiotolerance of bacterium S1H, the survival rate after increasing exposure was determined. R. rubrum S1H appeared relatively radiosensitive, as the radiation dose at which 90% of the population was killed (D10 value) was 4 times lower than the model bacterium Escherichia coli. It was demonstrate that the culture medium has an impact on radiation tolerance. This survival curve also permitted to select a number of sub-lethal ionizing radiation doses (¡ D10 ), that were used to analyze the gene expression response of R. rubrum S1H after gamma irradiation. The microarray transcriptome analysis results ob-tained from different doses and different culture medium showed a significant response of the bacterium to sublethal doses. Potential marker genes for ionizing radiation stress in R. rubrum S1H were identified. By quantitative PCR, it was shown that the expression of these marker genes increased with the recovery time after exposure to ionizing radiation. In other words, the radiation tolerance and the response of R. rubrum S1H to low energy Cobalt-60 gamma ionizing radiation was characterized. Therefore to ensure MELiSSA process robustness during extended space exploration mission, it is advised that

  12. Mutant strains of Spirulina (Arthrospira) platensis to increase the efficiency of micro-ecological life support systems (United States)

    Brown, Igor

    The European Micro-Ecological Life Support System Alternative (MELiSSA) is an advanced idea for organizing a bioregenerative system for long term space flights and extraterrestrial settlements (Hendrickx, De Wever et al., 2005). Despite the hostility of both lunar and Martian environments to unprotected life, it seems possible to cultivate photosynthetic bacteria using closed bioreactors illuminated and heated by solar energy. Such reactors might be employed in critical processes, e.g. air revitalization, foodcaloric and protein source, as well as an immunomodulators production. The MELiSSA team suggested cyanobacterium Spirulina as most appropriate agent to revitalize air and produce a simple "fast" food. This is right suggestion because Spirulina was recently shown to be an oxygenic organism with the highest level of O2 production per unit mass (Ananyev et al., 2005). Chemical composition of Spirulina includes proteins (55Aiming to make Spirulina cultivation in life support systems like MELiSSA more efficient, we selected Spirulina mutant strains with increased fraction of methionine in the biomass of this cyanobacterium and compared the effect of parental wild strain of Spirulina and its mutants on the tendency of such experimental illnesses as radiationinduced lesions and hemolythic anemia. Results: It was found that mutant strains 198B and 27G contain higher quantities of total protein, essential amino acids, c-phycocyanin, allophycocyanin and chlorophyll a than parental wild strain of S. platensis. The strain 198B is also characterized with increased content of carotenoids. Revealed biochemical peculiarities of mutant strains suggest that these strains can serve as an additional source of essential amino acids as well as phycobiliproteins and carotenoids for the astronauts. Feeding animals suffering from radiation-induced lesions, c-phycocyanin, extracted from strain 27G, led to a correction in deficient dehydrogenase activity and energy-rich phosphate levels

  13. Odpowiedź na pytanie

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    Michel Foucault


    Full Text Available Prezentowany artykuł Michela Foucaulta został opublikowany w 1963 roku. Foucault rozwija w nim koncepcję archeologii wiedzy – metody analizy historycznych dyskursów, którą zaprezentuje w sześć lat później w książce o tym właśnie tytule. Artykuł powstał na kanwie pytania wybranego przez autora spośród zadanych mu przez redakcję „Esprit”, które dotyczyło możliwości pojęciowego opracowania przymusu systemu dyskursywnego przy jednoczesnym zaakcentowaniu nieciągłości w jego obrębie a tym samym możliwości twórczego działania w historii ducha. A także, czy tak sformułowana aporia zakładałaby z konieczności zgodę na przymus systemu lub afirmację siły zdolnej do przekształcenia go za pomocą zewnętrznej przemocy? Tekst jest wprawką do sformułowania dojrzałej teorii dyskursu, rodzajem autoanalizy, która pozwala Foucaultowi powiązać własną metodę historyczną z „progresywistyczną polityką” myśli i rozwiązać w ten sposób dylemat pełnej determinacji i wolnego sprawstwa obecny w rozważaniach wielu strukturalistów.

  14. Optimal management of nail disease in patients with psoriasis

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    Piraccini BM


    Full Text Available Bianca Maria Piraccini, Michela Starace Division of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy Abstract: Psoriasis is a common skin disease, with nail involvement in approximately 80% of patients. Nail psoriasis is often associated with psoriatic arthropathy. Involvement of the nails does not always have relationship with the type, gravity, extension, or duration of skin psoriasis. Nail psoriasis can occur at any age and all parts of the nails and the surrounding structures can be affected. Two clinical patterns of nail manifestations have been seen due to psoriasis: nail matrix involvement or nail bed involvement. In the first case, irregular and deep pitting, red spots of the lunula, crumbling, and leukonychia are seen; in the second case, salmon patches, onycholysis with erythematous border, subungual hyperkeratosis, and splinter hemorrhages are observed. These clinical features are more visible in fingernails than in toenails, where nail abnormalities are not diagnostic and are usually clinically indistinguishable from other conditions, especially onychomycosis. Nail psoriasis causes, above all, psychosocial and aesthetic problems, but many patients often complain about functional damage. Diagnosis of nail psoriasis is clinical and histopathology is necessary only in selected cases. Nail psoriasis has an unpredictable course but, in most cases, the disease is chronic and complete remissions are uncommon. Sun exposure does not usually improve and may even worsen nail psoriasis. There are no curative treatments. Treatment of nail psoriasis includes different types of medications, from topical therapy to systemic therapy, according to the severity and extension of the disease. Moreover, we should not underestimate the use of biological agents and new therapy with lasers or iontophoresis. This review offers an investigation of the different treatment options for nail

  15. Psychological and behavioral disease during developmental age: the importance of the alliance with parents

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    Michela Gatta


    Full Text Available Michela Gatta1, Elisabetta Ramaglioni3, Jessica Lai3, Lorenza Svanellini3,  Irene Toldo1, Lara Del Col3, Cinzia Salviato3,  Andrea Spoto2,  Battistella Pier Antonio31Paediatrics Department, 2Department of General Psychology, University of Padua, Padua, Italy; 3Neuropsychiatric Unit for Children and Adolescents, Azienda ULSS 16, Padua, ItalyAbstract: The aim of the study is to analyze the clinician’s alliance with parents during the diagnostic process in relation to therapeutic compliance and clinical evolution of individuals aged 0–11 years. The sample was formed by 84 individuals aged 0 to 11 years (18 < 6 years, 66 aged 6 to 11 years; 62 males and 22 females who came to the Neuropsychiatric Unit for Children and Adolescents for a consultation regarding psychorelational and behavioral problems. Neuropsychiatric consultation took place in five diagnostic interviews with child and parents, separately. The last session was devoted to communication of psychiatric diagnosis (according to ICD 10 and therapeutic suggestions, if any. The clinician’s relationship with parents and patients’ participation were evaluated in terms of collaboration and quality of interaction, on the basis of pre-established criteria. Data about patients’ therapeutic compliance and clinical outcome were collected during a follow-up visit eight months after the last session. Results suggest that the better the alliance between parents and clinician, the higher the therapeutic compliance and the likelihood of a positive outcome for patients. Our data suggest that good communication with parents benefits child patients, both in terms of response to the parents’ need to report their children’s worrying behavior and as a response to the discomfort expressed by children when they come in for consultation.Keywords: psychopathology, developmental age, psychotherapy, alliance relationship, parental function

  16. Itinerari nella Weltliteratur: Norma e letteratura

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    a cura di Silvia Lafuente


    Full Text Available  This section consists of seven contributions from the 2012 Giornate di Studio, which have been taking place at the University of Florence since 2009: Silvia Lafuente, "Forme d’oralità costruiscono la modernità letteraria argentina nelle prime decadi del ‘900"; Arianna Fiore, "La junta luz di Juan Gelman: un oratorio contro il silenzio"; Carolina Argenta, "Oltre la Generazione del Sessanta: la poesia di Susana Thénon"; Salomé Vuelta García, "I proverbi nella traduzione italiana di La Familia de Pascual Duarte di Camilo José Cela; Andrea Carmelo Spadola, "Bilinguismo / Translinguismo nell’opera poetica di César Moro"; Coral García Rodríguez, "La formazione di una identità europea  attraverso il linguaggio: l’apolide Jorge Semprún, oppure lo spagnolo delle tre patrie"; Michela Graziani, "Trasformismi jazz nella cultura portoghese del ‘900".During the IV Giornata di Studio, the concepts of «norm» and «deviation» in literary language were discussed from a variety of standpoints: linguistic, literary, cultural, historical and social. The various lines of research chosen by the authors of the seven contributions to LEA highlight the potential of literary language in linguistic and intellectual experiences within cultural contexts. In the light of this perspective, the seven contributions offer a number of itineraries for the interpretation of modern literature from Argentina, Peru, Portugal and Spain. This section was edited by Silvia Lafuente. 

  17. Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs

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    Accardo A


    Full Text Available Antonella Accardo,1 Luigi Aloj,2 Michela Aurilio,2 Giancarlo Morelli,1 Diego Tesauro11Centro interuniversitario di Ricerca sui Peptidi Bioattivi (CIRPeB, Department of Pharmacy and Istituto di Biostrutture e Bioimmagini - Consiglio Nazionale delle Ricerche (IBB CNR, University of Naples “Federico II”, 2Department of Nuclear Medicine, Istituto Nazionale per lo Studio e la Cura dei Tumori, Fondazione “G. Pascale”, Napoli, ItalyAbstract: Active targeting by means of drug encapsulated nanoparticles decorated with targeting bioactive moieties represents the next frontier in drug delivery; it reduces drug side effects and increases the therapeutic index. Peptides, based on their chemical and biological properties, could have a prevalent role to direct drug encapsulated nanoparticles, such as liposomes, micelles, or hard nanoparticles, toward the tumor tissues. A considerable number of molecular targets for peptides are either exclusively expressed or overexpressed on both cancer vasculature and cancer cells. They can be classified into three wide categories: integrins; growth factor receptors (GFRs; and G-protein coupled receptors (GPCRs. Therapeutic agents based on nanovectors decorated with peptides targeting membrane receptors belonging to the GPCR family overexpressed by cancer cells are reviewed in this article. The most studied targeting membrane receptors are considered: somatostatin receptors; cholecystokinin receptors; receptors associated with the Bombesin like peptides family; luteinizing hormone-releasing hormone receptors; and neurotensin receptors. Nanovectors of different sizes and shapes (micelles, liposomes, or hard nanoparticles loaded with doxorubicin or other cytotoxic drugs and externally functionalized with natural or synthetic peptides are able to target the overexpressed receptors and are described based on their formulation and in vitro and in vivo behaviors.Keywords: receptors binding peptides, drug delivery

  18. Impulsivity, gender, and the platelet serotonin transporter in healthy subjects

    Directory of Open Access Journals (Sweden)

    Donatella Marazziti


    Full Text Available Donatella Marazziti, Stefano Baroni, Irene Masala, Francesca Golia, Giorgio Consoli, Gabriele Massimetti, Michela Picchetti, Mario Catena Dell’Osso, Gino Giannaccini, Laura Betti, Antonio Lucacchini, Antonio CiapparelliDipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, ItalyAbstract: The present study explored the possible relationships between impulsivity, gender, and a peripheral serotonergic marker, the platelet serotonin (5-HT transporter (SERT, in a group of 32 healthy subjects. The impulsivity was measured by means of the Barratt Impulsivity Scale, version 11 (BIS-11, a widely used self-report questionnaire, and the platelet SERT was evaluated by means of the specific binding of 3H-paroxetine (3H-Par to platelet membranes, according to standardized protocols. The results showed that women had a higher BIS-11 total score than men, and also higher scores of two factors of the same scale: the motor impulsivity and the cognitive complexity. The analysis of the correlations revealed that the density of the SERT proteins, as measured by the maximum binding capacity (Bmax of 3H-Par, was significantly and positively related to the cognitive complexity factor, but only in men. Men showed also a significant and negative correlation with the dissociation constant, Kd, of (3H-Par binding, and the motor impulsivity factor. These findings suggest that women are generally more impulsive than men, but that the 5-HT system is more involved in the impulsivity of men than in that of women.Keywords: impulsivity, gender, serotonin transporter, Barratt Impulsivity Scale, platelets, 3H-paroxetine

  19. Land and traditional knowledge: possible articulations in the indigenous school space

    Directory of Open Access Journals (Sweden)

    Antonio Jacó Brand


    Full Text Available Interferences are analyzed with regard to the historical processes of deterritorialization and territorial confinement among Kaiowá and Guarani populations in southern Mato Grosso, Brazil, on the production and re-signification of their traditional knowledge and wisdom and on possible difficulties in the eventual transition to school spaces. Foregrounded on Oliveira Filho (1999, Bhabha (2003, Sousa Santos (2005, Descola (1988, Melià; Grünberg and Grünberg (2008 and others, a review of the literature was undertaken as techno-methodological procedure with special reference to interviews with indigenous teachers. Partial results highlight the relevance of what happens inside the territory, especially the changes in social organization for processes related to traditional indigenous wisdom. Internal events, acknowledged as relevant spaces in the process, have had their importance reduced. Nevertheless, the indigenous way of reframing and translating their knowledge persists and pervades even the struggle against the historically imposed confinement.

  20. Prevalence of ectoparasitic arthropods on wild animals and cattle in the Las Merindades area (Burgos, Spain

    Directory of Open Access Journals (Sweden)

    Domínguez-Peñafiel G.


    Full Text Available This paper reports the prevalence of ectoparasitic arthropods in sampled groups of wild (n = 128; 16 species and domestic (n = 69; 3 species animals in the Las Merindades area of the Province of Burgos, Spain. The study revealed that wild animals were more infested and with a wider variety of ectoparasites than domestic animals. The parasitic prevalence was 67% for wild animals and 48% for livestock. In this way, 39% of animals were infected by ticks. Ixodes ricinus and Ixodes hexagonus were the most prevalent species whereas Dermacentor reticulatus showed affinity for the fox and wolf. The overall prevalence of parasitisation by fleas was 27%. Ctenophthalmus spp. showed the wider range host in wild animals, while Pulex irritans was the most frequent specie found. The parasitic prevalences by lice (Trichodectes melis, Trichodectes canis and Trichodectes mustelae and by mite (Neotrombicula spp., Laelaps agilis and Sarcoptes scabiei were 4% and 12%, respectively. In both cases only wild animals were found parasited.

  1. Helminth parasites of wild foxes (Vulpes vulpes L.) in The Netherlands. (United States)

    Borgsteede, F H


    To study the helminth fauna of wild foxes (Vulpes vulpes) in The Netherlands, material was collected from 139 foxes. The following parasites were found. Cestodes: Taenia spp. 53.3%, Hymenolepis spp. 1.5%; Trematodes: Alaria alata 10.9%, Cryptocotyle lingua 3.6%, Euparyphium melis 1.5%, Apophallus donicus 0.7%; Nematodes: Toxocara canis 73.7%, Uncinaria stenocephala 59.9%, Capillaria aerophila 46.8%, C. plica 23.5%, Molineus patens 5.1%, Crenosoma vulpis 4.5%, Strongyloides spp. 0.7%. The tapeworms Mesocestoides spp. and Echinococcus spp. were not seen. No relationship was observed between worm burden and sex, time of year or place of origin.

  2. Helminth parasites of the eurasian badger (Meles meles L.) in Spain: a biogeographic approach. (United States)

    Torres, J; Miquel, J; Motjé, M


    Eighty-five Eurasian badgers, Meles meles (Linnaeus, 1758), from four mainland biogeographic Spanish areas were analysed for helminths. Seventeen helminth species were found: Brachylaima sp., Euparyphium melis and Euryhelmis squamula (Trematoda), Atriotaenia incisa and Mesocestoides sp. (Cestoda) and Aelurostrongylus pridhami, Angiostrongylus vasorum, Aonchotheca putorii, Crenosoma melesi, Mastophorus muris, Molineus patens, Pearsonema plica, Physaloptera sibirica, Strongyloides sp., Trichinella sp., Uncinaria criniformis and Vigisospirura potekhina hugoti (Nematoda). In the Mediterranean area, Aonchotheca putorii, M. patens, Strongyloides sp., and U. criniformis were more prevalent in the occidental part, whereas Atriotaenia incisa and Mesocestoides sp. cestodes showed higher values on the continental slope. Metastrongyloid species (Aelurostrongylus pridhami, Angiostrongylus vasorum and Crenosoma melesi) were only detected in the occidental Mediterranean area. In contrast, spirurid species (Mastophorus muris and Vigisospirura potekhina hugoti) were almost restricted to the continental Mediterranean area. Helminthological differences between areas may result from the badger diet, abiotic factors and biocenosis present in each biogeographic area.

  3. Le Guaraní, patrimoine culturel immatériel du Paraguay : Théorie et pratique de la traduction d'après un manuscrit de 1651 du père Montoya



    Bartomeu MELIA est né à Porreres, Mayorque, Espagne en 1932. Jésuite, il est arrivé au Paraguay en 1954 où il a commencé l’étude de la langue et de la culture guarani avec le père Antonio Guasch comme professeur. Il a obtenu un doctorat de l’Université de Strasbourg en 1969 sur le thème « La création d’un langage chrétien dans les réductions des guarani au Paraguay ». Disciple et collaborateur de Don León Cardogan, Bartomeu Meliá a été professeur d’ethnographie et de culture guarani à l’Unive...

  4. 3 d -electron Heisenberg pyrochlore Mn2Sb2O7 (United States)

    Peets, Darren C.; Sim, Hasung; Avdeev, Maxim; Park, Je-Geun


    In frustrated magnetic systems, geometric constraints or the competition among interactions introduce extre-mely high degeneracy and prevent the system from readily selecting a low-temperature ground state. The most frustrated known spin arrangement is on the pyrochlore lattice, but nearly all magnetic pyrochlores have unquenched orbital angular momenta, constraining the spin directions through spin-orbit coupling. Pyrochlore Mn2Sb2O7 is an extremely rare Heisenberg pyrochlore system with directionally unconstrained spins and low chemical disorder. We show that it undergoes a spin-glass transition at 5.5 K, which is suppressed by disorder arising from Mn vacancies, indicating this ground state to be a direct consequence of the spins' interactions. The striking similarities to 3 d transition-metal pyrochlores with unquenched angular momenta suggests that the low spin-orbit coupling in the 3 d block makes Heisenberg pyrochlores far more accessible than previously imagined.



    Tomakin, Ercan


    ÖzetBu araştırmanın temel amacı YÖK'ün 2006-2007 eğitim-öğretim yılında,Türkiye'deki bütün Eğitim Fakülteleri'nin lisans programında uygulamaya koyduğuve zorunlu ders olarak okutacağı -Fakültemizde seçmeli ders olarak okuttuğumuz-Bilimsel Araştırma Yöntemleri (BAY) dersinin daha etkin, öğrenci-merkezli ve işlevselöğretilebilmesi için dikkate alınması gereken noktaları açıklamaktır. Bu yeni noktalarşunlardır: a) B...

  6. TIENDA DE LÁZARA [Material gráfico


    Fundación para la Etnografía y el Desarrollo de la Artesanía Canaria


    Antiguedad: SIGLO XX Calificación del suelo: RÚSTICO DE ASENTAMIENTO RURAL Clasificación del suelo: RÚSTICO Declaración BIC:No Desde hace 20 años esta tienda la llevan Lázara Rodríguez Nuez y su marido Bernardo Santana Melián. Los primeros tenderos fueron el matrimonio formado por José Rodríguez Rodríguez y Pino Nuez Jiménez, que comenzaron hacia el año 1940, cuando José había vuelto de Cuba, a donde emigró desde muy joven. En aquellos tiempos José también ejercía de barbero en e...

  7. Transmission-type SPR sensor based on coupling of surface plasmons to radiation modes using a dielectric grating

    Institute of Scientific and Technical Information of China (English)

    Changkui HU; Deming LIU


    A transmission-type surface plasmon resonance (SPR) sensor is presented. In the transmission-type SPR structure, surface plasmon waves are outcoupled to radia-tion modes by the use of dielectric grating on a thin-film layer of Ag. Compared with the traditional reflection-type SPR sensor, the new method provides larger detectable range, which might be useful to investigate thick targets such as in cell analysis. Theoretical simulations show that the structures provide high transmission efficiency for surface plasmon resonance and the devices present extre-mely linear sensing characteristics. Furthermore, it is found that the transmission efficiency and the refractive index detection sensitivity of the SPR sensor can be improved by the use of a lower refractive index glass prism.

  8. Immunopharmacology 2011: an updated report of clinical achievements and perspectives. (United States)

    Landys Chovel, Mario; Perea, Silvio; de los Ángeles Robinson, María; Rodeiro, Idania; Delgado, René; Ochoa, Rolando F; Hernández, Ana María


    On 26-30 June 2011 the Cuban Society of Pharmacology organized the Second International Congress on Immunopharmacology (Immunopharmacology 2011), held at the beautiful Convention Centre 'Plaza América' and the Meliá Varadero Hotel, in Varadero beach, Cuba. The main topics of the congress were immunopharmacology (including inflammation, cancer immunotherapy and immunomodulation), neuroimmunology, and the pharmacology of cytochrome P450 and transporters, among other relevant and updated related topics. Immunopharmacology 2011 offered an outstanding scientific program with the active contribution of 90 speakers from 23 foreign countries, as well as more than 170 Cuban researchers from the most important local institutions devoted to the development of immunology and pharmacology sciences.

  9. An expedient synthesis of linden ether. (United States)

    Serra, Stefano; Cominetti, Alessandra A


    We here describe a comprehensive study on the preparation of the intensive flavor 3,9-epoxy-p-mentha-1,4(8)-diene (1). Key steps of the presented synthesis are the selective addition of MeLi to the keto-ester 7, the regioselective cyclization of the obtained triol to give the ethers 4 and 8 and the selective dehydration of ether 4 through the use of POCI3 and pyridine. It is worth noting that the presented synthesis represents the first expedient and reliable entry to ether 1. Being present in linden honey, 1 is also known as linden ether and it has been regarded as a potential marker for the authentication of the linden honey origin. Therefore, ether 1 can be used as a useful reference standard for the analysis of the natural flavors, as we demonstrated by means of its identification in a sample ofunifloral linden honey.

  10. [Pd4(μ3-SbMe3)4(SbMe3)4]: A Pd(0) Tetrahedron with μ3-Bridging Trimethylantimony Ligands. (United States)

    Benjamin, Sophie L; Krämer, Tobias; Levason, William; Light, Mark E; Macgregor, Stuart A; Reid, Gillian


    The palladium(II) chlorostibine complex [PdCl2(SbMe2Cl)2]2 has a dimeric structure in the solid state, stabilized by hyper-coordination at the Lewis amphoteric Sb centers. Reaction with 8 equiv of MeLi forms [Pd4(μ3-SbMe3)4(SbMe3)4], whose structure comprises a tetrahedral Pd(0) core with four terminal SbMe3 ligands and four μ3-SbMe3 ligands, one capping each triangular Pd3 face. Density functional theory calculations, supported by energy decomposition analysis and the natural orbitals for chemical valence scheme, highlight significant donor and acceptor orbital contributions to the bonding between both the terminal and the bridging SbMe3 ligands and the Pd4 core.

  11. Experimental design and environmental parameters affect Rhodospirillum rubrum S1H response to space flight. (United States)

    Mastroleo, Felice; Van Houdt, Rob; Leroy, Baptiste; Benotmane, M Abderrafi; Janssen, Ann; Mergeay, Max; Vanhavere, Filip; Hendrickx, Larissa; Wattiez, Ruddy; Leys, Natalie


    In view of long-haul space exploration missions, the European Space Agency initiated the Micro-Ecological Life Support System Alternative (MELiSSA) project targeting the total recycling of organic waste produced by the astronauts into oxygen, water and food using a loop of bacterial and higher plant bioreactors. In that purpose, the alpha-proteobacterium, Rhodospirillum rubrum S1H, was sent twice to the International Space Station and was analyzed post-flight using a newly developed R. rubrum whole genome oligonucleotide microarray and high throughput gel-free proteomics with Isotope-Coded Protein Label technology. Moreover, in an effort to identify a specific response of R. rubrum S1H to space flight, simulation of microgravity and space-ionizing radiation were performed on Earth under identical culture set-up and growth conditions as encountered during the actual space journeys. Transcriptomic and proteomic data were integrated and permitted to put forward the importance of medium composition and culture set-up on the response of the bacterium to space flight-related environmental conditions. In addition, we showed for the first time that a low dose of ionizing radiation (2 mGy) can induce a significant response at the transcriptomic level, although no change in cell viability and only a few significant differentially expressed proteins were observed. From the MELiSSA perspective, we could argue the effect of microgravity to be minimized, whereas R. rubrum S1H could be more sensitive to ionizing radiation during long-term space exploration mission.

  12. Effect of halophilic conditions in stabilisation of RNA structure and function at high temperature under radiations. (United States)

    Maurel, M.-C.

    We have already shown the structural integrity of tRNA at high temperature - 82C for 30h - in high salt concentrations (Tehei et al, 2002). Stability were also performed by measuring the residual specific tRNA charge capacity after heat treatment for 30 h at 82C. RNA molecules are selected (in vitro selection) at high temperature at high salt concentration. We are undergoing studies of such molecules submitted to several stressful conditions, in particular high radiations. These studies provide support for the importance of salt to protect macromolecules against severe cosmic conditions. These could be useful for searching traces of life in planetary objects and space exploration. References : ElAmri, C., Baron, M-H., Maurel, M.-C. ``Adenine adsorption onto and release from meteorite specimens assessed by Surface Enhanced Raman Spectroscopy ''. Journal of Raman Spectroscopy (2004) in press. Meli, M., Vergne, J. and Maurel, M-C. "In vitro selection of adenine-dependent hairpin ribozymes" J. Biol. Chem., (2003), 278, 11, 9835-9842. ElAmri, C., Baron, M-H., Maurel, M.-C. ``Adenine in mineral samples : development of a methodology based on Surface Enhanced Raman Spectroscopy (SERS) for picomole detections ''. Spectrochimica Acta, A, 59, 2645-2654. Tehei, M., Franzetti, B., Maurel, M-C., Vergne, J., Hountondji, C. , Zaccai, G. ``Salt and the Search for Traces of Life '', Extremophiles, (2002), 6 : 427-430. Meli, M., Vergne, J., Décout, J.L., and Maurel, M-C. ``Adenine-Aptamer Complexes. A bipartite RNA site which binds the adenine nucleic base '', J. Biol. Chem., (2002), 277, 3, 2104-2111.

  13. Tris(bis(trimethylsilyl)amido)uranium: Compounds with tri-, tetra-, and penta-valent uranium

    Energy Technology Data Exchange (ETDEWEB)

    Stewart, J.L.


    This trivalent uranium compound, serves as a precursor to new tri-, tetra-, and penta-valent uranium species. The geometry about the U atom is pyramidal. Lewis-base coordination compounds of U(N(SiMe/sub 3/)/sub 2/)/sub 3/ with a one-to-one- ratio of Lewis base to uranium were isolated with pyridine, 4-dimethylamino-pyridine, 2,6-Me/sub 2/-C/sub 6/H/sub 3/NC, and TPO. Two-to-one coordination compounds were obtained with t-butylnitrile and t-butylisocyanide. Compounds with more sterically demanding bases could not be isolated. The expected decrease in U-N(SiMe/sub 3/)/sub 2/ bond length with increase in oxidation state is not observed. Reaction of ClU(N(SiMe/sub 3/)/sub 2/)/sub 3/and Li(NH(p-tolyl)) yields the uranium (IV) dimer, U/sub 2/(N(SiMe/sub 3/)/sub 2/)/sub 4/( 2/. Reaction with 2,4,6-triemethylaniline produces a dimer. Analogous substitution products could not be obtained with aniline or p-toluidine. t-Bu/sub 3/CO/sup /minus//, t-Bu/sub 2/CHO/sup /minus//, and t-Bu/sub 3/SiO/sup /minus// are used to synthesize new tetravalent, mononuclear uranium compounds. Reaction of ClU(tritox)/sub 3/ with alkyllithium reagents leads to isolation of RU(tritox)/sub 3/. The reaction of U(ditox)/sub 4/ with MeLi affords the addition product U(ditox)/sub 4/(Me)Li, whose crystal structure is described. Preparation of uranium silox compounds is reported. 97 refs., 26 figs., 39 tabs.

  14. Clinical evaluation of the efficacy and safety of a medical device in various forms containing Triticum vulgare for the treatment of venous leg ulcers – a randomized pilot study

    Directory of Open Access Journals (Sweden)

    Romanelli M


    Full Text Available Marco Romanelli,1 Michela Macchia,1 Salvatore Panduri,1 Battistino Paggi,1 Giorgio Saponati,2 Valentina Dini1 1Wound Healing Research Unit, Dermatology Division, Department of Clinical and Experimental Medicine, University of Pisa, 2ISPharm srl, Lucca, Italy Abstract: This study was carried out to assess the efficacy and tolerability of the topical application of an aqueous extract of Triticum vulgare (TV in different vehicles (cream, impregnated gauzes, foam, hydrogel, and dressing gel for the treatment of venous lower leg ulcers. Fifty patients were randomized to receive one of the five investigational vehicles. Treatment was performed up to complete healing or to a maximum of 29 days. The wound size reduction from baseline was the primary efficacy variable, which was measured by means of a noninvasive laser scanner instrument for wound assessment. In all groups, apart from the foam group, a similar trend toward the reduction of the surface area was observed. The cream showed the greatest effect on the mean reduction of the lesion size. At last visit, six ulcers were healed: two in the cream group, three in the gauze group, and one in the dressing gel group. In the patients treated with the cream, the gauzes, the hydrogel, and the dressing gel, the reduction of lesion size was 40%–50%; the reduction was smaller in the foam group. No impact in terms of age on the healing process was found. The Total Symptoms Score decreased in all groups during the study; a greater efficacy in terms of signs/symptoms was observed in the patients treated with the gauzes. In the dressing gel group, one patient had an infection of the wound after 3 weeks of treatment and 2 of colonization, leading to a systemic antibiotic treatment. The events were judged as nonrelated to the device used. On the basis of the results, it could be argued that the medical device may be useful in the treatment of chronic venous ulcers. Keywords: venous leg ulcers, Triticum vulgare

  15. New strategies to ensure good patient–physician communication when treating adolescents and young adults with cancer: the proposed model of the Milan Youth Project

    Directory of Open Access Journals (Sweden)

    Magni MC


    Full Text Available Maria Chiara Magni,1 Laura Veneroni,1 Carlo Alfredo Clerici,2 Tullio Proserpio,3 Giovanna Sironi,1 Michela Casanova,1 Stefano Chiaravalli,1 Maura Massimino,1 Andrea Ferrari1 1Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy; 2Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; 3Pastoral Care Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy Abstract: Adolescence is a particularly complex time of life, entailing physiological, psychological, and social changes that further the individual's cognitive, emotional, and social growth. Being diagnosed with cancer at this time can have important consequences on an individual's emotional and physical development, and adolescent and young adult cancer patients have particular medical and psychosocial needs. Patient–physician communications are important in any clinical relationship, but fundamental in the oncological sphere because their quality can affect the patient–physician relationship, the therapeutic alliance, and patient compliance. A major challenge when dealing with adolescent and young adult patients lies in striking the right balance between their need and right to understand their disease, treatment, and prognosis, and the need for them to remain hopeful and to protect their emotional sensitivity. We herein describe the activities of the Youth Project of the Istituto Nazionale Tumori in Milan, Italy in order to share a possible model of interaction with these special patients and the tactics our group has identified to help them communicate and share their thoughts. This model implies not only the involvement of a multidisciplinary team, including psychologists and spirituality experts, but also the constitution of dedicated creative activities to give patients the opportunity to express feelings they would otherwise never feel at ease putting into words. These efforts seek the goal to minimize the potentially

  16. Long-lasting corneal endothelial graft rejection successfully reversed after dexamethasone intravitreal implant

    Directory of Open Access Journals (Sweden)

    Giannaccare G


    Full Text Available Giuseppe Giannaccare, Michela Fresina, Alberto Pazzaglia, Piera Versura Ophthalmology Unit, Department of Experimental, Diagnostic and Specialty Medicine (DIMES, Alma Mater Studiorum University of Bologna, Sant’Orsola‑Malpighi Teaching Hospital, Bologna, Italy Abstract: Graft rejection is the most significant complication corneal transplantation and the leading indication for overall corneal transplantation. Corticosteroid therapy represents the mainstay of graft rejection treatment; however, the optimal route of administration of corticosteroid remains uncertain. We report herein for the first time the multimodal imaging of a case of long-lasting corneal endothelial graft rejection successfully reversed 3 months after dexamethasone intravitreal implant. A 29-year-old Asian female presented with a long-lasting corneal endothelial graft rejection in her left phakic eye. She underwent penetrating keratoplasty for advanced keratoconus 24 months before presentation. Hourly dexamethasone eyedrops, daily intravenous methylprednisolone, and one parabulbar injection of methylprednisolone acetate were administered during the 5 days of hospitalization. However, the clinical picture remained approximately unchanged despite therapy. By mutual agreement, we opted for the off-label injection of dexamethasone 0.7 mg intravitreal implant in order to provide therapeutic concentrations of steroid for a period of ~6 months. No other concomitant therapies were prescribed to the patient. Visual acuity measurement, slit lamp biomicroscopy, anterior segment photography, confocal microscopy, anterior segment optical coherence tomography, laser cell flare meter, intraocular pressure measurement, and ophthalmoscopy were performed monthly for the first postoperative 6 months. Three months after injection, both clinical and subclinical signs of rejection disappeared with a full recovery of visual acuity to 20/30 as before the episode. Currently, at the 12-month

  17. Illness denial questionnaire for patients and caregivers

    Directory of Open Access Journals (Sweden)

    Rossi Ferrario S


    Full Text Available Silvia Rossi Ferrario,1 Ines Giorgi,2 Paola Baiardi,3 Laura Giuntoli,4 Gianluigi Balestroni,1 Paola Cerutti,1 Marina Manera,2 Paola Gabanelli,2 Valentina Solara,5 Roberta Fornara,6 Michela Luisetti,1 Pierangela Omarini,1 Giovanna Omarini,1 Giulio Vidotto4 1Psychology Unit, Istituti Clinici Scientifici Maugeri SpA SB, Veruno, NO, Italy; 2Psychology Unit, 3Scientific Direction, Istituti Clinici Scientifici Maugeri SpA SB, Pavia, Italy; 4Department of General Psychology, University of Padova, Padova, Italy; 5Department of Neurology, ALS Centre, “Maggiore della Carita`” University Hospital, Novara, Italy; 6Psychology Unit, SS Trinità Hospital, Borgomanero, NO, Italy Purpose: Interest in assessing denial is still present, despite the criticisms concerning its definition and measurement. We tried to develop a questionnaire (Illness Denial Questionnaire, IDQ assessing patients’ and caregivers’ denial in relation to their illness/disturbance. Patients and methods: After a preliminary study, a final version of 24 dichotomous items (true/false was selected. We hypothesized a theoretical model with three dimensions: denial of negative emotions, resistance to change, and conscious avoidance, the first two composing the actual Denial and the last representing an independent component of the illness denial behavior. The IDQ was administered to 400 subjects (219 patients and 181 caregivers together with the Anxiety–Depression Questionnaire – Reduced form (AD-R, in order to assess concurrent validity. Confirmatory factor analysis (CFA, internal consistency indices (Cronbach’s α and McDonald’s ω, and test–retest analysis were performed. Results: CFA and internal consistency indices (Cronbach’s α: 0.87–0.96 indicated a clear and meaningful three-factor structure of IDQ, for both patients and caregivers. Further analyses showed good concurrent validity, with Denial and its subscale negatively associated with anxiety and depression and

  18. Ocular surface disease in patients with glaucoma or ocular hypertension treated with either BAK-preserved latanoprost or BAK-free travoprost

    Directory of Open Access Journals (Sweden)

    Gregory Katz


    Full Text Available Gregory Katz1, Clark L Springs2, E Randy Craven3, Michela Montecchi-Palmer41Huron Ophthalmology, Ypsilanti, MI, USA; 2Indiana University Eye Care, Indianapolis, IN, USA; 3Specialty Eye Care, Denver, CO, USA; 4Alcon Research Ltd., Fort Worth, TX, USAPurpose: The preservative benzalkonium chloride (BAK may adversely affect ocular surface health. This study evaluated symptoms of ocular surface disease (OSD in patients previously treated with a BAK-preserved therapy to lower their intraocular pressure, who either continued that therapy or switched to a BAK-free therapy.Methods: Eligible adult patients with ocular hypertension or open-angle glaucoma that had been controlled with BAK-preserved latanoprost 0.005% monotherapy (Xalatan® for at least one month and had a score of ≥ 13 (0 = none, 100 = most severe on the Ocular Surface Disease Index (OSDI questionnaire were entered into this prospective, double-masked, randomized, active-controlled, multicenter trial. By random assignment, patients either continued with BAK-preserved latanoprost 0.005% or transitioned to BAK-free travoprost 0.004% (Travatan Z® ophthalmic solution. OSDI scores were assessed again after six and 12 weeks.Results: For the 678 evaluable patients, mean change in OSDI score from baseline to week 12 favored the travoprost 0.004% BAK-free group, but was not statistically different between groups (P = 0.10. When patients with mild OSD at baseline were assessed after 12 weeks, the mean OSDI score was significantly lower (P = 0.04 in the BAK-free travoprost 0.004% group (score = 11.6 ± 10.8 units than in the BAK-preserved latanoprost 0.005% group (score = 14.4 ± 11.9 units, and a significantly larger percentage (P < 0.01 improved to normal OSDI scores in the BAK-free travoprost 0.004% group (62.9% of group than in the BAK-preserved latanoprost 0.005% group (47.0% of group. Patients pretreated with BAK-preserved latanoprost 0.005% for >24 months were significantly more likely (P

  19. Central airways remodeling in COPD patients

    Directory of Open Access Journals (Sweden)

    Pini L


    Full Text Available Laura Pini,1 Valentina Pinelli,2 Denise Modina,1 Michela Bezzi,3 Laura Tiberio,4 Claudio Tantucci1 1Unit of Respiratory Medicine, Department of Clinical and Experimental Sciences, University of Brescia, 2Department of Respiratory Medicine, Spedali Civili di Brescia, 3Department Bronchoscopy, Spedali Civili di Brescia, 4Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy Background: The contribution to airflow obstruction by the remodeling of the peripheral airways in chronic obstructive pulmonary disease (COPD patients has been well documented, but less is known about the role played by the large airways. Few studies have investigated the presence of histopathological changes due to remodeling in the large airways of COPD patients. Objectives: The aim of this study was to verify the presence of airway remodeling in the central airways of COPD patients, quantifying the airway smooth muscle (ASM area and the extracellular matrix (ECM protein deposition, both in the subepithelial region and in the ASM, and to verify the possible contribution to airflow obstruction by the above mentioned histopathological changes. Methods: Biopsies of segmental bronchi spurs were performed in COPD patients and control smoker subjects and immunostained for collagen type I, versican, decorin, biglycan, and alpha-smooth muscle actin. ECM protein deposition was measured at both subepithelial, and ASM layers. Results: The staining for collagen I and versican was greater in the subepithelial layer of COPD patients than in control subjects. An inverse correlation was found between collagen I in the subepithelial layer and both forced expiratory volume in 1 second and ratio between forced expiratory volume in 1 second and forced vital capacity. A statistically significant increase of the ASM area was observed in the central airways of COPD patients versus controls. Conclusion: These findings indicate that airway remodeling also affects

  20. Comparative study on diagonal equivalent methods of masonry infill panel (United States)

    Amalia, Aniendhita Rizki; Iranata, Data


    Infrastructure construction in earthquake prone area needs good design process, including modeling a structure in a correct way to reduce damages caused by an earthquake. Earthquakes cause many damages e.g. collapsed buildings that are dangerous. An incorrect modeling in design process certainly affects the structure's ability in responding to load, i.e. an earthquake load, and it needs to be paid attention to in order to reduce damages and fatalities. A correct modeling considers every aspect that affects the strength of a building, including stiffness of resisting lateral loads caused by an earthquake. Most of structural analyses still use open frame method that does not consider the effect of stiffness of masonry panel to the stiffness and strength of the whole structure. Effect of masonry panel is usually not included in design process, but the presence of this panel greatly affects behavior of the building in responding to an earthquake. In worst case scenario, it can even cause the building to collapse as what has been reported after great earthquakes worldwide. Modeling a structure with masonry panel as consideration can be performed by designing the panel as compression brace or shell element. In designing masonry panel as a compression brace, there are fourteen methods popular to be used by structure designers formulated by Saneinejad-Hobbs, Holmes, Stafford-Smith, Mainstones, Mainstones-Weeks, Bazan-Meli, Liauw Kwan, Paulay and Priestley, FEMA 356, Durani Luo, Hendry, Al-Chaar, Papia and Chen-Iranata. Every method has its own equation and parameters to use, therefore the model of every method was compared to results of experimental test to see which one gives closer values. Moreover, those methods also need to be compared to the open frame to see if they can result values within limits. Experimental test that was used in comparing all methods was taken from Mehrabi's research (Fig. 1), which was a prototype of a frame in a structure with 0.5 scale and the

  1. Simulated microgravity allows to demonstrate cell-to-cell communication in bacteria (United States)

    Mastroleo, Felice; van Houdt, Rob; Mergeay, Max; Hendrickx, Larissa; Wattiez, Ruddy; Leys, Natalie

    Through the MELiSSA project, the European Space Agency aims to develop a closed life support system for oxygen, water and food production to support human life in space in forth-coming long term space exploration missions. This production is based on the recycling of the missions organic waste, including CO2 and minerals. The photosynthetic bacterium Rhodospir-illum rubrum S1H is used in MELiSSA to degrade organics with light energy and is the first MELiSSA organism that has been studied in space related environmental conditions (Mastroleo et al., 2009). It was tested in actual space flight to the International Space Station (ISS) as well as in ground simulations of ISS-like ionizing radiation and microgravity. In the present study, R. rubrum S1H was cultured in liquid medium in 2 devices simulating microgravity conditions, i.e. the Rotating Wall Vessel (RWV) and the Random Positioning Machine (RPM). The re-sponse of the bacterium was evaluated at both the transcriptomic and proteomic levels using respectively a dedicated whole-genome microarray and high-throughput gel-free quantitative proteomics. Both at transcriptomic and proteomic level, the bacterium showed a significant response to cultivation in simulated microgravity. The response to low fluid shear modeled microgravity in RWV was different than to randomized microgravity in RPM. Nevertheless, both tests pointed out a change in and a likely interrelation between cell-to-cell communica-tion (i.e. quorum sensing) and cell pigmentation (i.e. photosynthesis) for R. rubrum S1H in microgravity conditions. A new type of cell-to-cell communication molecule in R. rubrum S1H was discovered and characterized. It is hypothised that the lack of convection currents and the fluid quiescence in (simulated) microgravity limits communications molecules to be spread throughout the medium. Cultivation in this new artificial environment of simulated micro-gravity has showed new properties of this well know bacterium

  2. Social y culturalmente ambiguos: criollos-mestizos de Tucumán, siglo XVII Socially and culturally ambiguous: criollo-mestizo population of Tucumán (Argentina, 17th century

    Directory of Open Access Journals (Sweden)

    Estela Noli


    Full Text Available Este artículo analiza la influencia de las sociedades indígenas sobre los descendientes de conquistadores españoles, los criollos. Se estudiará el caso de Juan Jordán de Trejo y los impedimentos presentados por una facción del cabildo de San Miguel de Tucumán a su admisión como teniente de gobernador. Este individuo descendía de una familia encomendera de Tafí, llamada Melián de Leguizamo y Guevara, pero pertenecía a una rama no favorecida del linaje y se desempeñaba como administrador de ese pueblo. Se indagará sobre las características de su mestizaje en el que destaca, a modo de espejo -de la españolización u occidentalización de los indios-, el manejo fluido de la lengua indígena, el conocimiento de las sociedades prehispánicas y sus territorios y el analfabetismo. Se analizará su rol como mediador interétnico (passeur culturel y las ventajas y obstáculos de este perfil en distintas coyunturas para el desempeño social y político en el grupo dominante.This article analyzes the influence of indigenous societies on the descendants of Spanish conquistadors, known as criollos. The subject is approached through a case study which shows how a faction of San Miguel de Tucumán town council (cabildo tried to prevent the admission of Juan Jordán de Trejo as deputy governor (teniente de gobernador. He belonged to the Melián de Leguizamo y Guevara family, owners of encomiendas in Tafí, but his lower lineage made him served as the town's administrator. Specific characteristics of his intercultural persona resembling a mirror image -referred to as Spanishization or Westernization of the Indians- will be studied, including his fluency in the indigenous language, his knowledge of pre-Hispanic societies and their territories and his illiteracy. His role as interethnic mediator (passeur culturel, and the advantages and drawbacks such a profile presents at different junctures, for social and political participation in the dominant

  3. Eighteen years of geochemical monitoring at the oceanic active volcanic island of El Hierro (Canary Islands, Spain) (United States)

    Asensio-Ramos, María; Alonso, Mar; Sharp, Emerson; Woods, Hannah; Barrancos, José; Pérez, Nemesio M.


    We report herein the latest results of a diffuse CO2 efflux survey at El Hierro volcanic system carried out during the summer period of 2015 to constrain the total CO2 output from the studied area a during post-eruptive period. El Hierro Island (278 km2) is the youngest and the SW-most of the Canary Islands. On July 16, 2011, a seismic-volcanic crisis started with the occurrence of more than 11,900 seismic events and significant deformation along the island. On October 10, 2011, the dominant character of seismicity changed dramatically from discrete earthquakes to continuous tremor, a clear indication that magma was rapidly approaching the surface immediately before the onset of the eruption, October 12. Eruption was declared over on 5 March, 2012. In order to monitor the volcanic activity of El Hierro Island, from 1998 to 2015 diffuse CO2 emission studies have been performed at El Hierro volcanic system in a yearly basis (˜600 observation sites) according to the accumulation chamber method. Spatial distribution maps were constructed following the sequential Gaussian simulation (sGs) procedure. To quantify the total CO2 emission from the studied area, 100 simulations for each survey have been performed. During the eruption period, soil CO2 efflux values range from non-detectable (˜0.5 g m-2 d-1) up to 457 g m-2 d-1, reaching in November 27, 2011, the maximum CO2 output estimated value of all time series, 2,398 t d-1, just before the episodes of maximum degassing observed as vigorous bubbling at the sea surface and an increment in the amplitude of the tremor signal. During the 2015 survey, soil CO2 efflux values ranged from non-detectable up to 41 g m-2 d-1. The spatial distribution of diffuse CO2 emission values seemed to be controlled by the main volcano structural features of the island. The total diffuse CO2 output released to atmosphere was estimated at 575 ± 24 t d-1, value slightly higher that the background CO2 emission estimated at 422 t d-1 (Melián et

  4. Fermentation as a first step in carbon and nutrient recovery in regenerative life support systems (United States)

    Luther, Amanda; Lasseur, Christophe; Rebeyre, Pierre; Clauwaert, Peter; Rabaey, Korneel; Ronsse, Frederik; Zhang, Dong Dong; López Barreiro, Diego; Prins, Wolter


    Long term manned space missions, such as the establishment of a base on Mars, will require a regenerative means of supplying the basic resources (i.e., food, water, oxygen) necessary to support human life. The MELiSSA-loop is a closed loop compartmentalized artificial aquatic ecosystem designed to recover water, carbon, and nutrients from solid organic wastes (e.g., inedible food waste and feces) for the regeneration of food and oxygen for humans. The first step in this loop is a strictly anaerobic fermentation unit operated as a membrane bioreactor. In this step the aim is to maximize the hydrolysis of complex organic compounds into simple molecules (CO2, ammonia, volatile fatty acids, …) which can be consumed by plants and bacteria downstream to produce food again. Optimal steady state fermentation of a standardized homogeneous mixture of beets, lettuce, wheat straw, toilet paper, feces, and water was demonstrated to recover approximately 50% of the influent carbon as soluble organics in the effluent through anaerobic fermentation. Approximately 10% of the influent COD was converted to CO2, with the remaining ~40% retained as a mixture of undigested solids and biomass. Approximately 50% of the influent nitrogen was recovered in the effluent, 97% of which was in the form of ammonia. Similar results have been obtained at both lab and pilot scale. With only 10% of the carbon driven to CO2 through this fermentation, a major challenge at this moment for the MELiSSA-loop is closing the carbon cycle, by completely oxidizing the carbon in the organic waste and non-edible parts of the plant into CO2 for higher plants and algae to fix again for food production. To further improve the overall degradation we are investigating the integration of a high temperature and pressure, sub- or near critical water conditions to improve the degradation of fibrous material with the addition of an oxidant (hydrogen peroxide, H2O2) under sub- or near critical conditions to further

  5. Preliminary investigations of the rhizosphere nature of hydroponically grown lettuces (United States)

    Antunes, Inês; Paille, Christel; Lasseur, Christophe

    Due to capabilities of current launchers, future manned exploration beyond the Earth orbit will imply long journeys and extended stays on planet surfaces. For this reason, it is of a great importance to develop a Regenerative Life Support System that enables the crew to be, to a very large extent, metabolic consumables self-sufficient. In this context, the European Space Agency, associated with a scientific and engineering con-sortium, initiated in 1989 the Micro-Ecological Life Support System Alternative (MELiSSA) project. This concept, inspired on a terrestrial ecosystem (i.e. a lake), comprises five intercon-nected compartments inhabited by micro-organisms and higher-plants aiming to produce food, fresh water, and oxygen from organic waste, carbon dioxide, and minerals. Given the important role of the higher-plant compartment for the consumption of carbon dioxide and the production of oxygen, potable water, and food, it was decided to study the microbial communities present in the root zone of the plants (i.e. the rhizosphere), and their synergistic and antagonistic influences in the plant growth. This understanding is important for later investigations concerning the technology involved in the higher plant compartment, since the final goal is to integrate this compartment inside the MELiSSA loop and to guarantee a healthy and controlled environment for the plants to grow under reduced-gravity conditions. To perform a preliminary assessment of the microbial populations of the root zone, lettuces were grown in a hydroponic system and their growth was characterized in terms of nutrient uptake, plant diameter, and plant wet and dry weights. In parallel, the microbial population, bacteria and fungi, present in the hydroponic medium and also inside and outside the roots were analyzed in terms of quantity and nature. The goal of this presentation is to give a preliminary review in the plant root zone of the micro-organisms communities and as well their proportions

  6. On the Chemical Evolution of Upper Mantle of the Early Earth—An Experimental Study on Melting of the Silicate Phase in Jilin Chondrite at High Pressures

    Institute of Scientific and Technical Information of China (English)

    谢鸿森; 方虹; 等


    Relatively old ages of chondrites(normally around 4.5Ga)suggest that their parent bodies did not experience any mely-fractionation under high temperature and high pressure conditions pertaining to the interior of terrestrial plaets.Therefore,it is reasonable to take chondrites as starting materials in the study of the chemical evolution of the early earth.The sillicate phase in the Jilin chondrite (H5)was chosen for this purpose because it possesses a chemical composition similar to that of the primitive mantle.The melting experiment was carried out at 20-30 k bar and has rsulted in a product which contains1-5% melts in addition to solid cryustal phase.The chemical composition of the melt phases and the partitioning of various elements between the coexisting silicate melts are geochemically similar to those of anatectic rocks on the earth.This can thus serve as the basis for discussing the chemical evolution of the early upper mantle.

  7. El poder en las organizaciones y su medición. El cuestionario de poder formal e informal

    Directory of Open Access Journals (Sweden)

    José Luis Meliá


    Full Text Available The mainpurpose of this papel´is to make a question naire for me asur ingrece ived power relationsin organization alsettings,and toverify the bifactorial structure of social power.The(ReceivedFormal-Informal Power Question-naire has iternsconcerning to the six bases of power defined by Raven(1989:legitimate, reward, coercion, expert, referent and informational, andtogeneral power. According to the Bifactorial The or y of SocialPower(Meliá,1984,these bases are group edintotwo dimensions: Formal and Informal Power. This questionnaire has showed as uitable reliabiliry and validity. The Bifactorial Theory of Social Power yields accurate and complex predictions regarding to th efactorial structure of the measurement, sorne objective indicators(Iike absolute and reIative hierarchiclevels,and sorne subjective indicators(suchascontact, communication and conflict. Four hundred and thirty-six social relations hipswere empirically analyzed foun dingsup portforall hypothesis.The Bifactorial Theory and itsassociate questionna ireal lows to obtain a new understanding of the organization albehaviour in the Role theory frame work

  8. Modelled microgravity cultivation modulates N-acylhomoserine lactone production in Rhodospirillum rubrum S1H independently of cell density. (United States)

    Mastroleo, Felice; Van Houdt, Rob; Atkinson, Steve; Mergeay, Max; Hendrickx, Larissa; Wattiez, Ruddy; Leys, Natalie


    The photosynthetic alphaproteobacterium Rhodospirillum rubrum S1H is part of the Micro-Ecological Life Support System Alternative (MELiSSA) project that is aiming to develop a closed life support system for oxygen, water and food production to support human life in space in forthcoming long-term space exploration missions. In the present study, R. rubrum S1H was cultured in a rotating wall vessel (RWV), simulating partial microgravity conditions on Earth. The bacterium showed a significant response to cultivation in simulated microgravity at the transcriptomic, proteomic and metabolic levels. In simulated microgravity conditions three N-acyl-l-homoserine lactones (C10-HSL, C12-HSL and 3-OH-C14-HSL) were detected in concentrations that were twice those detected under normal gravity, while no differences in cell density was detected. In addition, R. rubrum cultivated in modelled microgravity showed higher pigmentation than the normal gravity control, without change in culture oxygenation. When compared to randomized microgravity cultivation using a random positioning machine, significant overlap for the top differentially expressed genes and proteins was observed. Cultivation in this new artificial environment of simulated microgravity showed new properties of this well-known bacterium, including its first, to our knowledge, complete quorum-sensing-related N-acylhomoserine lactone profile.

  9. Prevalence of ectoparasitic arthropods on wild animals and cattle in the Las Merindades area (Burgos, Spain). (United States)

    Domínguez-Peñafiel, G; Giménez-Pardo, C; Gegúndez, Mi; Lledó, L


    This paper reports the prevalence of ectoparasitic arthropods in sampled groups of wild (n = 128; 16 species) and domestic (n = 69; 3 species) animals in the Las Merindades area of the Province of Burgos, Spain. The study revealed that wild animals were more infested and with a wider variety of ectoparasites than domestic animals. The parasitic prevalence was 67% for wild animals and 48% for livestock. In this way, 39% of animals were infected by ticks. Ixodes ricinus and Ixodes hexagonus were the most prevalent species whereas Dermacentor reticulatus showed affinity for the fox and wolf. The overall prevalence of parasitisation by fleas was 27%. Ctenophthalmus spp. showed the wider range host in wild animals, while Pulex irritans was the most frequent specie found. The parasitic prevalences by lice (Trichodectes melis, Trichodectes canis and Trichodectes mustelae) and by mite (Neotrombicula spp., Laelaps agilis and Sarcoptes scabiei) were 4% and 12%, respectively. In both cases only wild animals were found parasited.

  10. Cyanobacteria to Link Closed Ecological Systems and In-Situ Resources Utilization Processes (United States)

    Brown, Igor

    Introduction: A major goal for the Vision of Space Exploration is to extend human presence across the solar sys-tem. With current technology, however, all required consumables for these missions (propellant, air, food, water) as well as habitable volume and shielding to support human explorers will need to be brought from Earth. In-situ pro-duction of consumables (In-Situ Resource Utilization-ISRU) will significantly facilitate current plans for human ex-ploration and colonization of the solar system, especially by reducing the logistical overhead such as recurring launch mass. The production of oxygen from lunar materials is generally recognized as the highest priority process for lunar ISRU, for both human metabolic and fuel oxidation needs. The most challenging technology developments for future lunar settlements may lie in the extraction of elements (O, Fe, Mn, Ti, Si, etc) from local rocks and soils for life support, industrial feedstock and the production of propellants. With few exceptions (e.g., Johannson, 1992), nearly all technology development to date has employed an ap-proach based on inorganic chemistry (e.g. Allen et al., 1996). None of these technologies include concepts for inte-grating the ISRU system with a bioregenerative life support system and a food production systems. Bioregenerative life support efforts have recently been added to the Constellation ISRU development program (Sanders et al, 2007). Methods and Concerns: The European Micro-Ecological Life Support System Alternative (MELiSSA) is an ad-vanced concept for organizing a bioregenerative system for long term space flights and extraterrestrial settlements (Hendrickx, De Wever et al., 2005). However the MELiSSA system is a net consumer of ISRU products without a net return to in-situ technologies, e.g.. to extract elements as a result of complete closure of MELiSSA. On the other hand, the physical-chemical processes for ISRU are typically massive (relative to the rate of oxygen

  11. Proteome-wide analysis and diel proteomic profiling of the cyanobacterium Arthrospira platensis PCC 8005.

    Directory of Open Access Journals (Sweden)

    Sabine Matallana-Surget

    Full Text Available The filamentous cyanobacterium Arthrospira platensis has a long history of use as a food supply and it has been used by the European Space Agency in the MELiSSA project, an artificial microecosystem which supports life during long-term manned space missions. This study assesses progress in the field of cyanobacterial shotgun proteomics and light/dark diurnal cycles by focusing on Arthrospira platensis. Several fractionation workflows including gel-free and gel-based protein/peptide fractionation procedures were used and combined with LC-MS/MS analysis, enabling the overall identification of 1306 proteins, which represents 21% coverage of the theoretical proteome. A total of 30 proteins were found to be significantly differentially regulated under light/dark growth transition. Interestingly, most of the proteins showing differential abundance were related to photosynthesis, the Calvin cycle and translation processes. A novel aspect and major achievement of this work is the successful improvement of the cyanobacterial proteome coverage using a 3D LC-MS/MS approach, based on an immobilized metal affinity chromatography, a suitable tool that enabled us to eliminate the most abundant protein, the allophycocyanin. We also demonstrated that cell growth follows a light/dark cycle in A. platensis. This preliminary proteomic study has highlighted new characteristics of the Arthrospira platensis proteome in terms of diurnal regulation.

  12. Proteome-wide analysis and diel proteomic profiling of the cyanobacterium Arthrospira platensis PCC 8005. (United States)

    Matallana-Surget, Sabine; Derock, Jérémy; Leroy, Baptiste; Badri, Hanène; Deschoenmaeker, Frédéric; Wattiez, Ruddy


    The filamentous cyanobacterium Arthrospira platensis has a long history of use as a food supply and it has been used by the European Space Agency in the MELiSSA project, an artificial microecosystem which supports life during long-term manned space missions. This study assesses progress in the field of cyanobacterial shotgun proteomics and light/dark diurnal cycles by focusing on Arthrospira platensis. Several fractionation workflows including gel-free and gel-based protein/peptide fractionation procedures were used and combined with LC-MS/MS analysis, enabling the overall identification of 1306 proteins, which represents 21% coverage of the theoretical proteome. A total of 30 proteins were found to be significantly differentially regulated under light/dark growth transition. Interestingly, most of the proteins showing differential abundance were related to photosynthesis, the Calvin cycle and translation processes. A novel aspect and major achievement of this work is the successful improvement of the cyanobacterial proteome coverage using a 3D LC-MS/MS approach, based on an immobilized metal affinity chromatography, a suitable tool that enabled us to eliminate the most abundant protein, the allophycocyanin. We also demonstrated that cell growth follows a light/dark cycle in A. platensis. This preliminary proteomic study has highlighted new characteristics of the Arthrospira platensis proteome in terms of diurnal regulation.

  13. Helminth communities of the autochthonous mustelids Mustela lutreola and M. putorius and the introduced Mustela vison in south-western France. (United States)

    Torres, J; Miquel, J; Fournier, P; Fournier-Chambrillon, C; Liberge, M; Fons, R; Feliu, C


    This study presents the first comprehensive helminthological data on three sympatric riparian mustelids (the European mink Mustela lutreola, the polecat M. putorius and the American mink M. vison) in south-western France. One hundred and twenty-four specimens (45 M. lutreola, 37 M. putorius and 42 M. vison) from eight French departments were analysed. Globally, 15 helminth species were detected: Troglotrema acutum, Pseudamphistomum truncatum, Euryhelmis squamula, Euparyphium melis and Ascocotyle sp. (Trematoda), Taenia tenuicollis (Cestoda), Eucoleus aerophilus, Pearsonema plica, Aonchotheca putorii, Strongyloides mustelorum, Molineus patens, Crenosoma melesi, Filaroides martis and Skrjabingylus nasicola (Nematoda) and larval stages of Centrorhynchus species (Acanthocephala). The autochthonous European mink harboured the highest species richness (13 species) followed by the polecat with 11 species. The introduced American mink presented the most depauperate helminth community (nine species). The prevalence and worm burden of most of the helminths found in M. putorius and M. lutreola were also higher than those of M. vison. Some characteristics of their helminth communities were compared to relatively nearby populations (Spain) and other very distant populations (Belarus). This comparison emphasized M. patens as the most frequent parasite in all of the analysed mustelid populations. It was possible to conclude that the invasive M. vison contributes to the maintenance of the life cycle of the pathogenic T. acutum and S. nasicola helminths, with possible implications for the conservation of the endangered European mink.

  14. Trichophyton onychocola sp. nov. isolated from human nail. (United States)

    Hubka, Vit; Cmokova, Adela; Skorepova, Magdalena; Mikula, Peter; Kolarik, Miroslav


    A previously undescribed Trichophyton species was isolated from the nail of a 33-year-old man with a history of probable distal lateral subungual onychomycosis (without confirmation by mycological examination). The infection occurred for the first time five years earlier (in 2006) and affected the right great toenail, with complete clinical remission after treatment with ciclopirox olamine. This undescribed species was isolated during probable relapse in 2011, but its etiological significance was not confirmed, that is, direct microscopy was negative and additional clinical samples were not collected. The species is probably geophilic based on phylogenetic analysis (internal transcribed spacer [ITS] rDNA) and is most closely related to the anamorphic T. thuringiense, homothallic Arthroderma ciferrii (anamorph T. georgiae), and heterothallic A. melis. The new species is characterized by yellowish colonies, red reverse on several media, positive urease test, negative hair-perforation test, absence of growth at 34°C, absence of macroconidia, formation of one-celled clavate microconidia, and spiral hyphae. The species grows well on sterilized human hairs placed on agar medium without any additional nutrients and forms gymnothecium-like structures covered by peridial hyphae. The combination of unique micro- and macromorphological features and physiological and sequence data from four unlinked loci (ITS, benA, RPB2, and act1 gene) justified the proposal of a new species T. onychocola sp. nov.

  15. Finding Inspiration in the Protein Data Bank to Chemically Antagonize Readers of the Histone Code. (United States)

    Campagna-Slater, Valérie; Schapira, Matthieu


    Members of the Royal family of proteins are readers of the histone code that contain aromatic cages capable of recognizing specific sequences and lysine methylation states on histone tails. These binding modules play a key role in epigenetic signalling, and are part of a larger group of epigenetic targets that are becoming increasingly attractive for drug discovery. In the current study, pharmacophore representations of the aromatic cages forming the methyl-lysine (Me-Lys) recognition site were used to search the Protein Data Bank (PDB) for ligand binding pockets possessing similar chemical and geometrical features in unrelated proteins. The small molecules bound to these sites were then extracted from the PDB, and clustered based on fragments binding to the aromatic cages. The compounds collected are numerous and structurally diverse, but point to a limited set of preferred chemotypes; these include quaternary ammonium, sulfonium, and primary, secondary and tertiary amine moieties, as well as aromatic, aliphatic or orthogonal rings, and bicyclic systems. The chemical tool-kit identified can be used to design antagonists of the Royal family and related proteins. Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. Working with Space and Shape in Early Childhood Education: Experiences in Collaboration

    Directory of Open Access Journals (Sweden)

    Karina Luiza da Silva Fernandes


    Full Text Available This report shows the experience of a work conducted with the Meli-Melo puzzle in two early childhood education classes at two different schools in the state of São Paulo, Brazil. With the work’s activities as a starting point, aspects related to space and shape, as well as quantities and measures, were approached. Children from two and a half to five years old participated in the playful activities, which had the following goals: to develop spatial and geometric skills, to allow measuring actions, to favor dialogue and to boost group work experience. There were several activities, like handling the pieces, assembling images freely or according with outlines and models, assembling three-dimensional figures, and the length game. The following questions were considered in the evaluation of the work: how was the children’s participation in large groups and small groups? How did children of different age groups engage in the different proposals? Which activities were easier or more difficult for each group? Which behaviors and conversations showed us new knowledge? The fulfillment of the planned activities showed that the children had several hypotheses regarding shapes and that they were able to identify similarities and differences, use geometry vocabulary, and discuss their thoughts, particularly when working in small groups, which favored the participation of nearly all children. We believe the work reported has allowed learnings and a contact with mathematics in early childhood education.

  17. Studi Islam Indonesia: Bibliografi Disertasi Terpilih 1900-1979

    Directory of Open Access Journals (Sweden)

    Endy Saputro


    Full Text Available Menulis bibliografi ibarat melukis sebuah peta keilmuan, agar seorang sarjana paham dimana novelti riset yang akan dikajinya. Entah sejak kapan tradisi ini “hilang” dari dunia akademik di Indonesia; satu hal yang pasti Mely G. Tan dalam Metode-Metode Penelitian Masyarakat (1977 masih merekam beberapa bibliografi tentang Indonesia yang masih terbit di awal tahun 70-an. Di era serba digital ini, bibliografi telah tergantikan dengan kemunculan database elektronik yang memiliki fitur “pencarian” cepat, seperti Proquest, Ebsco atau Springer. Tidak seperti dulu yang mengharuskan seorang peneliti mengumpulkan data referensi secara manual, kini dengan berbagai citation manager software yang ada (EndNote, Mendeley, Zotero, RefWorks dan lain sebagainya, seorang peneliti dapat menyimpan-dan-memanggil kembali referensi secara cepat dan otomatis. Namun, fasilitas tersebut bukannya tanpa kelemahan. Daya jangkau akses peneliti masih berperan dalam proses penjaringan data referensi. Untuk itulah, usaha ini merupakan sebuah ikhtiar menghidupkan tradisi menulis bibiografi, dengan batas-kajian pada studi Islam Indonesia.

  18. A magyar hallgatók vállalkozásindító szándékát befolyásoló tényezők modellje - Ajzen tervezett magatartás elméletének kiterjesztése (Model of the Hungarian students’ business start-up intention influencing factors – Extending of Ajzen’s Theory of Planned Behavior)


    S. Gubik, Andrea


    A vállalkozási tevékenység a munkahelyteremtés és a gazdasági növekedés egyik döntő tényezője. Ennek a jövőbeli kedvező alakulását a fiatalok mai attitűdjei határozzák meg. Ha be tudjuk azonosítani a legfontosabb tényezőket, amelyek a fiatalok vállalkozásindítási szándékát befolyásolják, el tudjuk dönteni azt is, mely területen lehet és érdemes beavatkozni annak érdekében, hogy minél több új, életképes vállalkozás szülessen. A cikk a GUESSS kutatási projekt magyarországi adatbázis...

  19. A multiple index integrating different levels of organization. (United States)

    Cortes, Rui; Hughes, Samantha; Coimbra, Ana; Monteiro, Sandra; Pereira, Vítor; Lopes, Marisa; Pereira, Sandra; Pinto, Ana; Sampaio, Ana; Santos, Cátia; Carrola, João; de Jesus, Joaquim; Varandas, Simone


    Many methods in freshwater biomonitoring tend to be restricted to a few levels of biological organization, limiting the potential spectrum of measurable of cause-effect responses to different anthropogenic impacts. We combined distinct organisational levels, covering biological biomarkers (histopathological and biochemical reactions in liver and fish gills), community based bioindicators (fish guilds, invertebrate metrics/traits and chironomid pupal exuviae) and ecosystem functional indicators (decomposition rates) to assess ecological status at designated Water Framework Directive monitoring sites, covering a gradient of human impact across several rivers in northern Portugal. We used Random Forest to rank the variables that contributed more significantly to successfully predict the different classes of ecological status and also to provide specific cut levels to discriminate each WFD class based on reference condition. A total of 59 Biological Quality Elements and functional indicators were determined using this procedure and subsequently applied to develop the integrated Multiple Ecological Level Index (MELI Index), a potentially powerful bioassessment tool. Copyright © 2016 Elsevier Inc. All rights reserved.

  20. Türevli lıe halkaları


    ARSLAN, Berna


    Bu tezde, birleşmeli bir R halkasının türevlerinin oluşturduğu Der (R) Lie halkasının yapısı üzerine günümüze kadar yapılan çalışmalarda elde edilen bazı özelliklere yer verilmiştir. Bu tez beş bölümden oluşmaktadır. İlk bölümde, tez konusu tanıtılmış ve bu konu ile ilgili yapılmış olan çalışmaların kısa bir özeti verilmiştir. İkinci bölümde, bu tezi anlamada kolaylık sağlayacak bazı temel tanım ve özelliklere değinilmiştir. Üçüncü bölümde, Lie halka yapısının ve bu konudaki çalışmaların daha...

  1. 8th European Conference on Rare Diseases & Orphan Products (ECRD 2016

    Directory of Open Access Journals (Sweden)

    Michael Schlander


    Full Text Available Table of contents O1 The European Social Preferences Measurement (ESPM study project: social cost value analysis, budget impact, commercial life cycle revenue management, and the economics of biopharmaceutical Research & Development (R&D Michael Schlander, Søren Holm, Erik Nord, Jeff Richardson, Silvio Garattini, Peter Kolominsky-Rabas, Deborah Marshall, Ulf Persson, Maarten Postma, Steven Simoens, Oriol de Solà Morales, Keith Tolley, Mondher Toumi, Harry Telser O2 Newborn Screening: the potential and the challenges James R Bonham O3 Untreatable disease outcomes - how would we measure them? Helmut Hintner, Anja Diem, Martin Laimer O4 Taking Integrated Care Forward: Experiences from Canada to inspire service provision for people living with rare disease in Europe Réjean Hébert O5 Listening to the patient’s voice: social media listening for safety and benefits in rare diseases Nabarun Dasgupta, Carrie E. Pierce, Melissa Jordan O6 Via Opta: Mobile apps making visually impaired patients’ lives easier Barbara Bori, Mohanad Fors, Emilie Prazakova O7 A report of the IRDiRC “Small Population Clinical Trial” Task Force Simon Day O8 HAE patient identification and diagnosis: An innovative, ‘game changing’ collaboration Thomas J. Croce Jr. O9 Co-creating with the community: primary packaging & administration for people with haemophilia Jonas Fransson, Philip Wood O10 Go with Gaucher, taking forward the next generation. How to involve young people to create a new generation of patient advocates Anne-Grethe Lauridsen, Joanne Higgs, Vesna Stojmirova Aleksovska P1 ODAK – Orphan Drug for Acanthamoeba Keratitis Christina Olsen, Ritchie Head, Antonio Asero, Vincenzo Papa, Christa van Kan, Loic Favennec, Silvana Venturella, Michela Salvador, Alan Krol P5 Rare Navigators help people living with rare diseases to manage the social – and healthcare systems Stephanie J. Nielsen, Birthe B. Holm P6 The eAcademy for Tay-Sachs & Sandhoff disease app


    Directory of Open Access Journals (Sweden)

    Alfredo Eugenio Leal Santana


    Full Text Available El presente trabajo constituye la concepción y realización de un esquema de conmutaciónautomática de líneas de entrada al ocurrir fallas en ellas, basado en autómatas programablesy aplicable principalmente a subestaciones del tipo distribuidoras aunque puede serimplementado en otros tipos de subestaciones para otros esquemas de conmutación. Elesquema permite además la reconfiguración automática al restablecerse el servicio normala la subestación.Se implementa además la posibilidad del control remoto del esquema como elementosubordinado al actual Sistema de Telemando o del SCADA pudiendo además serimplementado en el futuro como parte de cualquiera de estos Sistemas.La implementación de estos esquemas permite una mayor confiabilidad en la operación delas instalaciones y una mayor seguridad y rapidez en la conmutación de las líneas lo queeleva la calidad del servicio que se brinda a los consumidores. La utilización de autómatasprogramables permite una mejor coordinación con las automáticas propias de los consumidorese incluso la posibilidad de que futuros clientes puedan decidir la inclusión o no de estasautomáticas propias en sus nuevas inversiones.Este esquema se encuentra instalado y en servicio desde el mes de abril del presente año enla subestación distribuidora Monte Barreto, la cual brinda servicio a una extensa zona turísticay de negocios con instalaciones como los hoteles Comodoro, Meliá Havana, Neptuno-Tritóne inmobiliarias arrendadas a instituciones extranjeras.  The present paper constitutes the conception and realization of a layout for the automaticcommutation of entrance lines when happening faults in them, based on ProgrammableLogic Controller and applicable mainly to substations of the type distributors, although itcan be implemented in other types of substations for other commutation layouts. This onealso allows the automatic reconfiguration when recovering the normal service to thesubstation.It is

  3. Diffuse degassing He/CO2 ratio before and during the 2011-12 El Hierro submarine eruption, Canary Islands (United States)

    Padrón, Eleazar; Hernández, Pedro A.; Melián, Gladys V.; Barrancos, José; Padilla, Germán; Pérez, Nemesio M.; Dionis, Samara; Rodríguez, Fátima; Asensio-Ramos, María; Calvo, David


    El Hierro Island (278 km2) is the youngest and the SW-most of the Canary Islands. On July 16, 2011, a seismic-volcanic crisis started with the occurrence of more than 11,900 seismic events and significant deformation along the island, culminating with the eruption onset in October 12. Since at El Hierro Islands there are not any surface geothermal manifestation (fumaroles, etc), we have focused our studies on soil degassing surveys. Between July 2011 to March 2012, seventeen diffuse CO2 and He emissions soil gas surveys were undertaken at El Hierro volcanic system (600 observation sites) with the aim to investigate the relationship between their temporal variations and the volcanic activity (Padrón et al., 2013; Melián et al., 2014). Based on the diffuse He/CO2 emission ratio, a sharp increase before the eruption onset was observed, reaching the maximum value on September 26 (6.8×10-5), sixteen days before the occurrence of the eruption. This increase coincided with an increase in seismic energy release during the volcanic unrest and occurred together with an increase on the 3He/4He isotopic ratio in groundwaters from a well in El Hierro Island (Padrón et al., 2013; from 2-3 RA to 7.2 RA where RA = 3He/4He ratio in air), one month prior to the eruption onset. Early degassing of new gas-rich magma batch at depth could explain the observed increase on the He/CO2 ratio, causing a preferential partitioning of CO2 in the gas phase with respect to the He, due to the lower solubility of CO2 than that of He in basaltic magmas. During the eruptive period (October 2011-March 2012) the prevalence of a magmatic CO2-dominated component is evident, as indicated by the generally lower He/CO2 ratios and high 3He/4He values (Padrón et al., 2013). The onset of the submarine eruption might have produced a sudden release of volcanic gases, and consequently, a decrease in the volcanic gas pressure of the magma bodies moving beneath the island, reflected by a drastic decrease in

  4. Molecular exploration of the highly radiation resistant cyanobacterium Arthrospira sp. PCC 8005 (United States)

    Badri, Hanène; Leys, Natalie; Wattiez, Ruddy

    Arthrospira (Spirulina) is a photosynthetic cyanobacterium able to use sunlight to release oxygen from water and remove carbon dioxide and nitrate from water. In addition, it is suited for human consumption (edible). For these traits, the cyanobacterium Arthrospira sp. PCC 8005 was selected by the European Space Agency (ESA) as part of the life support system MELiSSA for recycling oxygen, water, and food during future long-haul space missions. However, during such extended missions, Arthrospira sp. PCC 8005 will be exposed to continuous artificial illumination and harmful cosmic radiation. The aim of this study was to investigate how Arthrospira will react and behave when exposed to such stress environment. The cyanobacterium Arthrospira sp. PCC 8005 was exposed to high gamma rays doses in order to unravel in details the response of this bacterium following such stress. Test results showed that after acute exposure to high doses of 60Co gamma radiation upto 3200 Gy, Arthrospira filaments were still able to restart photosynthesis and proliferate normally. Doses above 3200 Gy, did have a detrimental effect on the cells, and delayed post-irradiation proliferation. The photosystem activity, measured as the PSII quantum yield immediately after irradiation, decreased significantly at radiation doses above 3200 Gy. Likewise through pigment content analysis a significant decrease in phycocyanin was observed following exposure to 3200 Gy. The high tolerance of this bacterium to 60Co gamma rays (i.e. ca. 1000x more resistant than human cells for example) raised our interest to investigate in details the cellular and molecular mechanisms behind this amazing resistance. Optimised DNA, RNA and protein extraction methods and a new microarray chip specific for Arthrospira sp. PCC 8005 were developed to identify the global cellular and molecular response following exposure to 3200 Gy and 5000 Gy A total of 15,29 % and 30,18 % genes were found differentially expressed in RNA

  5. Subcritical and supercritical water oxidation of organic, wet wastes for carbon cycling in regenerative life support systems (United States)

    Ronsse, Frederik; Lasseur, Christophe; Rebeyre, Pierre; Clauwaert, Peter; Luther, Amanda; Rabaey, Korneel; Zhang, Dong Dong; López Barreiro, Diego; Prins, Wolter; Brilman, Wim


    For long-term human spaceflight missions, one of the major requirements is the regenerative life support system which has to be capable of recycling carbon, nutrients and water from both solid and liquid wastes generated by the crew and by the local production of food through living organisms (higher plants, fungi, algae, bacteria, …). The European Space Agency's Life Support System, envisioned by the MELiSSA project, consists of a 5 compartment artificial ecosystem, in which the waste receiving compartment (so-called compartment I or briefly 'CI') is based on thermophilic fermentation. However, as the waste generated by the crew compartment and food production compartment contain typical plant fibres (lignin, cellulose and hemicellulose), these recalcitrant fibres end up largely unaffected in the digestate (sludge) generated in the C-I compartment. Therefore, the C-I compartment has to be supplemented with a so-called fibre degradation unit (in short, FDU) for further oxidation or degradation of said plant fibres. A potential solution to degrading these plant fibres and other recalcitrant organics is their oxidation, by means of subcritical or supercritical water, into reusable CO2 while retaining the nutrients in an organic-free liquid effluent. By taking advantage of the altered physicochemical properties of water above or near its critical point (647 K, 22.1 MPa) - including increased solubility of non-polar compounds and oxygen, ion product and diffusivity - process conditions can be created for rapid oxidation of C into CO2. In this research, the oxidizer is provided as a hydrogen peroxide solution which, at elevated temperature, will dissociated into O2. The purpose of this study is to identify ideal process conditions which (a) ensure complete oxidation of carbon, (b) retaining the nutrients other than C in the liquid effluent and (c) require as little oxidizer as possible. Experiments were conducted on a continuous, tubular heated reactor and on batch

  6. 褪黑激素受体亚型Mel1a在大弹涂鱼体内的分布%Localization of Melatonin Receptor Mel1a in Mudskipper (Boleophthalmus pectinirostris)

    Institute of Scientific and Technical Information of China (English)

    朱文博; 连惠波; 洪万树; 陈仕玺; 陈原; 王琼; 张其永


    Melatonin and its receptors are the essential regulators that transmit environmental stimulations to the brain in the verte-brates,and may also regulate the bi-monthly spawning of the mudskipper (Boleophthalmus pectinirostris) during the spawning season. However,the localization and tissue expression of melatonin receptors in mudskipper are lacking. In the present study, the expression of melatonin receptor subtype Meli, in retina,brain,pituitary,pineal gland,gonad,small intestine of the mudskipper was examined using immunohistochemistry. We found irnmuno-positive reaction to Melt, antibody in the photosensory cells,outer plexiform, internal nuclear and internal plexiform layers of the retina. The immuno-positive responses were also observed in the cerebellum, the optic tectum s stratum fibrosum marginale,stratum marginal,neurohypophysis,proximal pars distalis of the pituitary,the pineal vesicle,dorsal sac of the pineal gland,leydig cells,spermatogonia,spermatocytes,spermatid,follicle layer of ovary,the outside edge of columnar epithelium,and the muscular layer of the intestine. The extend expression of melatonin receptor,Mella,in the wide-range tissue types suggest that melatonin may be involved in the regulation of multiple physiological functions including the reproduction in the mudskipper. This study was a necessary step in the way to more precisely identify the sites of the melatonin receptor subtype Meli, in the fish,its regulation and respective roles.%运用免疫组织化学方法研究了褪黑激素受体亚型Mel1a在大弹涂鱼视网膜、脑部、垂体、松果体、性腺和小肠中的分布.结果表明,Mel1a分布于视网膜的感光细胞层、外丛状层、内核层和神经节细胞层;小脑分子层;视顶盖边缘层和视觉层;垂体的神经垂体和腺垂体的中外侧部;松果体终囊及背囊;精巢的间质细胞、精原细胞、精母细胞以及精子细胞;卵膜的滤泡细胞;小肠的柱状上皮细胞外沿和肌肉

  7. Low Earth orbit journey and ground simulations studies point out metabolic changes in the ESA life support organism Rhodospirillum rubrum (United States)

    Mastroleo, Felice; Leys, Natalie; Benotmane, Rafi; Vanhavere, Filip; Janssen, Ann; Hendrickx, Larissa; Wattiez, Ruddy; Mergeay, Max

    MELiSSA (Micro-Ecological Life Support System Alternative) is a project of closed regenerative life support system for future space flights developed by the European Space Agency. It consists of interconnected processes (i.e. bioreactors, higher plant compartments, filtration units,..) targeting the total recycling of organic waste into oxygen, water and food. Within the MELiSSA loop, the purple non-sulfur alpha-proteobacterium R. rubrum ATCC25903 is used to convert fatty acids released from the upstream raw waste digesting reactor to CO2 and biomass, and to complete the mineralization of aminoacids into NH4+ that will be forwarded to the nitrifying compartment. Among the numerous challenges of the project, the functional stability of the bioreactors in long term and under space flight conditions is of paramount importance for the efficiency of the life support system and consequently the crew safety. Therefore, the physiological and metabolic changes induced by space flight were investigated for R. rubrum. The bacterium grown on solid medium during 2 different 10-day space flights to the ISS (MES- SAGE2, BASE-A experiments) were compared to cells grown on Earth 1 g gravity or modeled microgravity and normal Earth radiation or simulated space flight radiation conditions in order to relate each single stress to its respective cellular response. For simulating the radiation environment, pure gamma and neutron sources were combined, while simulation of changes in gravity where performed using the Random Positioning Machine technology. Transcriptome analysis using R. rubrum total genome DNA-chip showed up-regulation of genes involved in oxidative stress response after a 10-day mission inside the ISS, without loss of viability. As an example, alkyl hydroperoxide reductase, thioredoxin reductase and bacterioferritin genes are least 2 fold induced although the radiation dose experienced by the bacterium (4 mSv) is very low compared to its radiotolerance (D10 = 100 Sv

  8. Chelate bis(imino)pyridine cobalt complexes: synthesis, reduction, and evidence for the generation of ethene polymerization catalysts by Li+ cation activation. (United States)

    Kleigrewe, Nina; Steffen, Winfried; Blömker, Tobias; Kehr, Gerald; Fröhlich, Roland; Wibbeling, Birgit; Erker, Gerhard; Wasilke, Julia-Christina; Wu, Guang; Bazan, Guillermo C


    Treatment of the bis(iminobenzyl)pyridine chelate Schiff-base ligand 8 (ligPh) with FeCl2 or CoCl2 yielded the corresponding (ligPh)MCl2 complexes 9 (Fe) and 10 (Co). The reaction of 10 with methyllithium or "butadiene-magnesium" resulted in reduction to give the corresponding (ligPh)Co(I)Cl product 11. Similarly, the bis(aryliminoethyl)pyridine ligand (ligMe) was reacted with CoCl2 to yield (ligMe)CoCl2 (12). Reduction to (ligMe)CoCl (13) was effected by treatment with "butadiene-magnesium". Complex 13 reacted with Li[B(C6F5)4] in toluene followed by treatment with pyridine to yield [(ligMe)Co+-pyridine] (15). The reaction of the Co(II) complexes 10 or 12 with ca. 3 molar equiv of methyllithium gave the cobalt(I) complexes 16 and 17, respectively. Treatment of the (ligMe)CoCH3 (17) with Li[B(C6F5)4] gave a low activity ethene polymerization catalyst. Likewise, complex 16 produced polyethylene (activity = 33 g(PE) mmol(cat)(-1) h(-1) bar(-1) at room temperature) upon treatment with a stoichiometric amount of Li[B(C6F5)4]. A third ligand (lig(OMe)) was synthesized featuring methoxy groups in the ligand backbone (22). Coordination to FeCl2 and CoCl2 yielded the desired compounds 23 and 24. Reaction with MeLi gave (ligOMe)CoMe (25/26). Treatment of 25/26 with excess B(C6F5)3 gave the eta6-arene cation complex 27, where one Co-N linkage was cleaved. Activation of 25/26 with Li[B(C6F5)4] again gave a catalytically active species.

  9. Removal of nitrate from liquid effluents with bio-nano hybrid materials (United States)

    Eroglu, Ela; Haniff Wahid, M.; Chen, Xianjue; Smith, Steven M.; Raston, Colin L.


    Microalgae are a group of microorganisms that are abundant in the environment and have been commonly used as a tool for sustainable green technologies including bioenergy production1,2, CO2 sequestration2, wastewater treatment3,4, and nutritional supplement5. We have recently developed a hybridization process between common microalgal cells (Chlorella vulgaris) and multi-layer graphene sheets4. Graphene has very strong adhesion energies6 with an ability to attach on the surface of microalgal cells, which results in a functional hybrid material. Initially dynamic thin films formed within a microfluidic platform, as a vortex fluidic device, were used to exfoliate multi-layer graphene from graphite flakes in water. This was followed by hybridizing the multi-layer graphene with microalgal cells. The resulting bio-nano hybrid material was particularly efficient for the removal of nitrate from liquid effluents without being toxic for the microalgal cells. Scanning electron microscopy, transmission electron microscopy, atomic force microscopy, and Raman spectroscopy techniques were used for the characterization of the formed graphene sheets, with the fluorescence microscopy and chlorophyll content analyzed for monitoring the viability and growth pattern of the microalgal cells. E. Eroglu and A. Melis, Biotechnol. Bioeng., 2009, 102(5), 1406-1415. É. C Francisco, D. B. Neves, E. Jacob-Lopes, and T. T. Franco, J. Chem. Technol. Biotechnol., 2010, 85, 395-403. E. Eroglu, V. Agarwal, M. Bradshaw, X. Chen, S.M. Smith, C.L. Raston and K.S. Iyer, Green Chem., 2012, 14(10), 2682 - 2685. M. H. Wahid, E. Eroglu, X. Chen, S.M. Smith, and C.L. Raston, Green Chem., 2012, doi:10.1039/C2GC36892G. P. Spolaore, C. Joannis-Cassan, E. Duran and A. Isambert, J. Biosci. Bioeng., 2006, 101, 87-96. S. P. Koenig, N. G. Boddeti, M. L. Dunn and J. S. Bunch, Nat. Nanotechnol., 2011, 6, 543-546.

  10. Noćne more Carlosa Fuentesa

    Directory of Open Access Journals (Sweden)

    Una Krizmanić Ožegović


    Full Text Available U Iraku se zvao Salim Abdul Husain i radio je za općinu kao čistač, u skupini kojoj je upravitelj dodijelio zadatak čišćenja nakon eksplozija. Umro je 2009. u Nizozemskoj pod drugim imenom: Carlos Fuentes. Salim i njegovi kolege, puni dosade i gnušanja, kao i svakoga drugog jadnog dana, čistili su tržnicu nakon što je eksplodirao tegljač s gorivom, zapalivši piliće, voće, povrće i pokojeg čovjeka. Meli su pažljivo i polako od straha da ne pokupe neki zaostali komad ljudskoga tijela. Uvijek su tražili netaknutu lisnicu ili možda zlatni lanac, prsten ili sat koji je još pokazivao vrijeme. U potrazi za posmrtnim dragocjenostima Salim nije imao sreće kao njegovi kolege. Trebao mu je novac za vizu kako bi otišao u Nizozemsku i pobjegao iz ovog vatrenoga užasa prepunoga smrti. Samo mu se jedanput posrećilo pa je našao prst s dragocjenim srebrnim prstenom, vrlo lijepim. Salim je poklopio prst stopalom, pažljivo se sagnuo i skinuo prsten s gađenjem. Prsten je završio na Salimovoj ruci, zadivljeno je promatrao dragi kamen i na kraju odustao od pomisli da ga proda. Može li se reći da je osjetio duboku duhovnu povezanost s prstenom?

  11. Precursor life science experiments and closed life support systems on the Moon (United States)

    Rodriguez, A.; Paille, C.; Rebeyre, P.; Lamaze, B.; Lobo, M.; Lasseur, C.

    Nowadays the Moon is not only a scientific exploration target but also potentially also a launch pad for deeper space exploration. Establishing an extended human presence on the Moon could reduce the cost of further space exploration, and gather the technical and scientific experience that would make possible the next steps of space exploration, namely manned-missions to Mars. To enable the establishment of such a Moon base, a reliable and regenerative life support system (LSS) is required: without any recycling of metabolic consumables (oxygen, water and food), a 6-person crew during the course of one year would require a supply of 12t from Earth (not including water for hygiene purposes), with a prohibitive associated cost! The recycling of consumables is therefore mandatory for a combination of economic, logistical and also safety reasons. Currently the main regenerative technologies used, namely water recycling in the ISS, are physical-chemical but they do not solve the issue of food production. In the European Space Agency, for the last 15 years, studies are being performed on several life support topics, namely in air revitalisation, food, water and waste management, contaminants, monitoring and control. Ground demonstration, namely the MELiSSA Pilot Plant and Concordia Station, and simulation studies demonstrated the studies feasibility and the recycling levels are promising. To be able to build LSS in a Moon base, the temperature amplitude, the dust and its 14-day night, which limits solar power supply, should be regarded. To reduce these technical difficulties, a landing site should be carefully chosen. Considering the requirements of a mission to the Moon and within the Aurora programme phase I, a preliminary configuration for a regenerative LSS can be proposed as an experiment for a precursor mission to the Moon. An overview of the necessary LSS to a Moon base will be presented, identifying Moon?s specific requirements and showing preliminary

  12. Efectos sobre el estado de ánimo en jóvenes tenistas de diferentes volúmenes de entrenamiento de alta intensidad

    Directory of Open Access Journals (Sweden)

    Manuel Moya


    Full Text Available El objetivo de este estudio fue analizar la influencia del incremento de la carga de entrenamiento por medio del método Repeated Sprint Ability (RSA sobre el estado de ánimo de jóvenes tenistas. Participaron 30 tenistas (15.78 ± 1.58 a ̃ nos en este programa de entrena- miento (7 semanas. Los sujetos fueron divididos en tres grupos: G1, volumen de entrenamiento de tenis más un incremento del 8.3% por medio de RSA; G2, ídem más un incremento de 16.6% de RSA; y G3, entrenamiento de tenis. El entrenamiento específico de tenis fue controlado e igualado, además se cumplimentó un cuestionario semanal para establecer el perfil de estado de ánimo (Balaguer, Fuentes, Meliá, García-Mérita & Pons, 1995. Los resultados mostraron variaciones en G1 y G2. Mientras en G1 las puntuaciones de los factores tensión y fatiga se incrementaron al final del programa ( p < .05, en G2 aumentaron las puntuaciones de tensión, depresión, hostilidad y fatiga al comienzo del programa, y se redujeron significativamente al final ( p < .05. En G3 no hubo modificaciones. La diferente evolución del estado de ánimo de los sujetos en función del volumen de entrenamiento de RSA realizado, muestra la necesidad de monitorizar la carga interna para ajustar este entrenamiento

  13. Consistencia y fluctuación de los estados de ánimo en un equipo de fútbol profesional durante una competición de play off

    Directory of Open Access Journals (Sweden)

    Ricardo de la Vega Marcos


    Full Text Available El objetivo de este estudio es describir los procesos de estado de ánimo de un equipo de fútbol profesional durante la competición, mediante la administración de tests específicos. Se ha evaluado mediante la versión corta española (15 items, Fuentes, García-Merita, Meliá y Balaguer, 1995 del Perfil de Estados de Ánimo (POMS, MacNair, Lorr and Droppelmann, 1971, un equipo de fútbol profesional de 2ª división B (Rayo Vallecano SAD, Madrid antes de la disputa de los cuatro partidos de la fase de play off de ascenso a 2ª A al final de la temporada regular de la Liga Española de Fútbol Profesional 2006-07. Los resultados han mostrado la ausencia de diferencias significativas en los valores de las cinco escalas del POMS (Depresión, Vigor, Cólera, Fatiga y Tensión recogidos antes de los cuatro partidos del play off, indicando la existencia de consistencia en los estados de ánimo del equipo durante la fase eliminatoria, y la ausencia de fluctuaciones significativas en los procesos de estado de ánimo a medio plazo. A pesar de esto, las representaciones gráficas de las medias del POMS muestran la existencia de tendencias hacia patrones distintos relacionados con las diversas escalas. Sugerimos que este método propuesto es útil para estudiar los procesos cognitivo-emocionales de los deportistas y de los equipos durante determinados tipos de competición, a la vez que asegura un nivel elevado de validez ecológica y provee información para efectuar intervenciones más efectivas y adaptadas a los equipos.

  14. Beyond the raccoon roundworm: The natural history of non-raccoon Baylisascaris species in the New World

    Directory of Open Access Journals (Sweden)

    Sarah G.H. Sapp


    Full Text Available A total of 10 species of Baylisascaris, a genus of ascaridoid nematodes, occur worldwide and 6 of them occur in the New World. Most of the Baylisascaris species have a similar life cycle with carnivorous mammals or marsupials serving as definitive hosts and a smaller prey host serving as paratenic (or intermediate hosts. However, one species in rodents is unique in that it only has one host. Considerable research has been conducted on B. procyonis, the raccoon roundworm, as it is a well-known cause of severe to fatal neurologic disease in humans and many wildlife species. However, other Baylisascaris species could cause larva migrans but research on them is limited in comparison. In addition to concerns related to the potential impacts of larva migrans on potential paratenic hosts, there are many questions about the geographic ranges, definitive and paratenic host diversity, and general ecology of these non-raccoon Baylisascaris species. Here, we provide a comprehensive review of the current knowledge of New World Baylisascaris species, including B. columnaris of skunks, B. transfuga and B. venezuelensis of bears, B. laevis of sciurids, B. devosi of gulonids, B. melis of badgers, and B. potosis of kinkajou. Discussed are what is known regarding the morphology, host range, geographic distribution, ecoepidemiology, infection dynamics in definitive and paratenic hosts, treatment, and control of these under-studied species. Also, we discuss the currently used molecular tools used to investigate this group of parasites. Because of morphologic similarities among larval stages of sympatric Baylisascaris species, these molecular tools should provide critical insight into these poorly-understood areas, especially paratenic and definitive host diversity and the possible risk these parasites pose to the health to the former group. This, paired with traditional experimental infections, morphological analysis, and field surveys will lead to a greater

  15. Beyond the raccoon roundworm: The natural history of non-raccoon Baylisascaris species in the New World. (United States)

    Sapp, Sarah G H; Gupta, Pooja; Martin, Melissa K; Murray, Maureen H; Niedringhaus, Kevin D; Pfaff, Madeleine A; Yabsley, Michael J


    A total of 10 species of Baylisascaris, a genus of ascaridoid nematodes, occur worldwide and 6 of them occur in the New World. Most of the Baylisascaris species have a similar life cycle with carnivorous mammals or marsupials serving as definitive hosts and a smaller prey host serving as paratenic (or intermediate) hosts. However, one species in rodents is unique in that it only has one host. Considerable research has been conducted on B. procyonis, the raccoon roundworm, as it is a well-known cause of severe to fatal neurologic disease in humans and many wildlife species. However, other Baylisascaris species could cause larva migrans but research on them is limited in comparison. In addition to concerns related to the potential impacts of larva migrans on potential paratenic hosts, there are many questions about the geographic ranges, definitive and paratenic host diversity, and general ecology of these non-raccoon Baylisascaris species. Here, we provide a comprehensive review of the current knowledge of New World Baylisascaris species, including B. columnaris of skunks, B. transfuga and B. venezuelensis of bears, B. laevis of sciurids, B. devosi of gulonids, B. melis of badgers, and B. potosis of kinkajou. Discussed are what is known regarding the morphology, host range, geographic distribution, ecoepidemiology, infection dynamics in definitive and paratenic hosts, treatment, and control of these under-studied species. Also, we discuss the currently used molecular tools used to investigate this group of parasites. Because of morphologic similarities among larval stages of sympatric Baylisascaris species, these molecular tools should provide critical insight into these poorly-understood areas, especially paratenic and definitive host diversity and the possible risk these parasites pose to the health to the former group. This, paired with traditional experimental infections, morphological analysis, and field surveys will lead to a greater understanding of


    Directory of Open Access Journals (Sweden)

    Bonaci Carmen Giorgiana


    Full Text Available Our paper contributes to the literature on international accounting by focusing on the standard setting process. As documented by research literature, accounting regulation can enhance corporate governance (Melis and Carta, 2010, corporate reporting being expected to reduce information asymmetry. Based on accounting research and trade literature we first synthesize recent evolutions in the international accounting arena. We therefore position our study within current realities significantly marked by uncertainty in relation to the world wide globalization process. The objective of our paper is to perform an analysis that would help assess further developments of the convergence project. This is done by looking at the current status of the projects being developed under the IASB –FASB collaboration, as well as by developing a comparison between IFRS and US GAAP. The employed research methodology relies on analyzing data provided through the IASB and the FASB’s websites, as well as other official documents being issued by the two Boards. The assessment of the projects was done by reviewing exposure documents and monitoring the Boards’ deliberations, while the developed comparison requires accounting regulations content analysis. Concluding upon the Boards’ ongoing projects, we might identify areas in which convergence seems to be quite close (such as revenue recognition and leasing, but also areas in which convergence becomes even more challenging (such as financial instruments or the particular case of offsetting. Similar to other studies being developed within accounting research and trade literature (SEC 2011: 8 we may conclude that, generally, US GAAP present more detailed, specific requirements than IFRS.

  17. PhD Dissertations

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    Redazione Reti Medievali (a cura di


    Full Text Available Report of PhD Dissertations. Federica Cengarle Le investiture feudali di Filippo Maria Visconti (1412-1447, Tesi di dottorato di ricerca in Storia medievale, Università degli Studi di Milano, 2005 Silvia Coazzin Liberi domini totius castri. L'aristocrazia rurale "minore" nel Senese e nella Toscana meridionale. Forme di egemonia, assetto sociale e patrimoniale di lignaggi, famiglie e gruppi consortili di castello (secc. XI-XIV, Tesi di dottorato di ricerca in Storia medievale, Università degli studi di Firenze, 2005 Maria Elena Cortese Signori e castelli. Famiglie aristocratiche, dominati signorili e trasformazioni insediative nel comitatus fiorentino (fine X-metà XII secolo, Tesi di dottorato di ricerca in Storia medievale, Università degli studi di Firenze, 2005 Patrizia Meli Gabriele Malaspina marchese di Fosdinovo: il condottiero ed il politico, Tesi di dottorato di ricerca in Storia medievale, Università degli studi di Firenze, 2005 Federica Pessotto La Morea franca. Economia e istituzioni tra Oriente e Occidente nei secoli XIII e XIV, Tesi di dottorato di ricerca in Istituzioni, Società e Religioni dal Tardoantico alla fine del Medioevo, Università degli studi di Torino, 2003 Lorenzo Pubblici Dal Caucaso al Mar d’Azov. L’impatto dell’invasione mongola nella Caucasia fra nomadismo e civiltà sedentaria (1204-1395, Tesi di dottorato di ricerca in Storia medievale, Università degli studi di Firenze, 2005 [01/05] Riccardo Rao "Comunia". Risorse collettive e patrimoniali dei maggiori comuni subalpini (secoli XII - inizio XIV, Tesi di dottorato di ricerca in Storia medioevale, Università degli Studi di Milano, 2005 Alessandro Soddu Feudalesimo e potere signorile in Sardegna nei secoli XI-XIV.  La signoria territoriale dei Malaspina, Tesi di dottorato di ricerca in Storia, Università "Pompeu Fabra" di Barcellona, 2004


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    Full Text Available El objetivo de este trabajo fue determinar marcadores palinológicos que permitieran caracterizar el origen geográfico y botánico de mieles provenientes de los departamentos de Boyacá, Cundinamarca, Santander y Magdalena. Se realizaron análisis meli- sopalinológicos de 184 muestras de miel procedentes de 131 apiarios. Se determinaron diferencias significativas entre tipos de mieles mediante un análisis discriminante y comparando la composición de especies entre las muestras. En total se encontraron 297 especies distribuidas en 69 familias, dentro de las cuales las más representativas fueron Mimosa sp., Cecropia sp., Eucalyptus sp., Piper sp. y Quercus humboldtii. Las familias más importantes fueron Fabaceae, Asteraceae,Myrtaceae, Rubiaceae, Fagaceae, y Melastomataceae. Se lograron determinar seis grupos de mieles diferenciadas por su origen geográfico: altiplano Cundiboyacense, Medio Chicamocha, Sumapaz, Bajo Chicamocha, Sierra Nevada de Santa Marta y provincia Comunera; también se encontraron diferencias entre las mieles de las regiones andinas y subandinas. Dentro de los tipos de mieles diferenciadas por origen botánico predominaron las mieles monoflorales de Trifolium pratense, Coffea arabica, Eucalyptus sp., Inga sp. y Heliocarpus americanus, mieles oligoflorales de asteráceas y mezclas de mielato de Q. humboldtii y néctar floral (Eucalyptus sp. tipo Brassicaceae, asteráceas. La información de este trabajo junto con la obtenida en análisis fisicoquímicos y sensoriales servirá de base para que los apicultores puedan solicitar la denominación de origen de estas mieles.

  19. Soybean cultivation for Bioregenerative Life Support Systems (BLSSs): The effect of hydroponic system and nitrogen source (United States)

    Paradiso, Roberta; Buonomo, Roberta; Dixon, Mike A.; Barbieri, Giancarlo; De Pascale, Stefania


    Soybean [Glycine max (L.) Merr.] is one of the plant species selected within the European Space Agency (ESA) Micro-Ecological Life Support System Alternative (MELiSSA) project for hydroponic cultivation in Biological Life Support Systems (BLSSs), because of the high nutritional value of seeds. Root symbiosis of soybean with Bradirhizobium japonicum contributes to plant nutrition in soil, providing ammonium through the bacterial fixation of atmospheric nitrogen. The aim of this study was to evaluate the effects of two hydroponic systems, Nutrient Film Technique (NFT) and cultivation on rockwool, and two nitrogen sources in the nutrient solution, nitrate (as Ca(NO3)2 and KNO3) and urea (CO(NH2)2), on root symbiosis, plant growth and seeds production of soybean. Plants of cultivar 'OT8914', inoculated with B. japonicum strain BUS-2, were grown in a growth chamber, under controlled environmental conditions. Cultivation on rockwool positively influenced root nodulation and plant growth and yield, without affecting the proximate composition of seeds, compared to NFT. Urea as the sole source of N drastically reduced the seed production and the harvest index of soybean plants, presumably because of ammonium toxicity, even though it enhanced root nodulation and increased the N content of seeds. In the view of large-scale cultivation for space colony on planetary surfaces, the possibility to use porous media, prepared using in situ resources, should be investigated. Urea can be included in the nutrient formulation for soybean in order to promote bacterial activity, however a proper ammonium/nitrate ratio should be maintained.

  20. Study on Main Constructive Species of Fengshui Woods in Zhongshan City%中山市风水林主要建群树种研究

    Institute of Scientific and Technical Information of China (English)

    修小娟; 孙红梅; 彭伯雄


    采用样方法对广东省中山市66个风水林进行调查,结果表明:保存完整及较完整的有41个,风水林评定等级为 A 级的有35个;中山市风水林植物种类丰富,共有维管植物149科388属603种,其中野生植物141科334属509种,栽培植物42科77属94种;主要建群树种有43科92属121种,其中以樟科、桃金娘科、大戟科、含羞草科、苏木科、芸香科、楝科为主,共56种;分布区类型以热带为主,共107种。%Zhongshan city has 66 Fengshui woods which located in 9 districts.Based on field investigation, there were 41 Fengshui woods that still remained intact,and 35 that were rated as A-class.The plant resources of Fengshui woods in Zhongshan are plentiful.There were 603 species of wild vascular plants belonging to 388 genera in 149 families,in which 121 species of the main constructive species belonging to 92 genera in 43 families,mainly including 56 species like Lauraceae,Myrtaceae,Euphorbiaceae,Mimosaceae,Caesalpiniaceae,Rutaceae,Meli-aceae,etc.The seed plant areal-type of Fengshui woods in Zhongshan city was mainly tropical element,and were insist of 107 species.

  1. MAQÂSHID AL-SYARÎ’AH AL-SYÂTHÎBÎ (Sebuah Upaya untuk Menyingkap Tujuan Asasi Formulasi Hukum Islam

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    Abdul Jalil Abdul Jalil


    Full Text Available Abstract: The al-Qur’ân is the only source of law by muslims believed to contain the rules guidelines and guidence to live in the word and the hereafter. Understand it (al-Qur’ân requires a skill as well expertise, especially in the filed of linguistics  (rule lughâwiyyah so as to understand the meaning of the word of god as defailed in the al-qur’ân. But god’s law is written in mushhaf sheets are also has the meaning that can be understood from what is implied  behind the text, a fundamental goal (maqâshid al-syarî’ah of legal provisions in nashshîyyah. In the article the author wants to give an alternative understanding of the idea of a reformer of islamic legal thought that al-Syâthîbî in maqâshid al-syarî’ah outlines in his monumental work. Entitled al-muwâfaqât fî usûl al-syarî’ah . Whit this idea, the observer of islamic law is expected in understanding the law of god is not mely because there is an assessment tekts, but also expected more attention to and consider the fundamental purpose of the establishment of law of god. Key Words: al-Qur’ân, maqâshid al-syarî’ah, al-Syâthîbi, dan mashlahah


    Institute of Scientific and Technical Information of China (English)

    吕永兴; 吴创之; 潘贤齐; 阴秀丽; 熊祖鸿


    Synthesis of liquefied petroleum gas (LPG) from reforming of biomass syngas using hybrid catalyst consisting of methanol synthesis catalyst (MeLi) and HZSM-5 zeolite was investigated. The results show that the best reaction temperature of bifunctional catalyst is 325℃ and the best range of reaction pressure is 2. 1-3. 6MPa, and the CO conversion achieved 83. 25% at 3251 , 2. IMPa, 2000h-1. The weight percentage content of target products achieved 83. 17% in organic products. Cu( 111) was assumed to be the active phase for DME synthesis, confirmed by X-ray diffraction (XRD) characterization.%以甲醇催化剂(MeLi)与HZSM-5型分子筛机械混合,制备LPG合成催化剂.通过对流化床制备的生物质气重整脱碳后进行合成LPG研究.结果表明,LPG合成最佳反应温度为325℃,最佳反应压力范围为2.1 ~ 3.6MPa.在325℃,2.1MPa,2000h-1条件下,CO单程转化率达83.25%,目标产物C3+C4占有机产物质量含量已达83.17%.通过XRD对催化剂反应前后进行表征,催化剂活性中心为Cu(111).通过计算,每吨干基木质生物质可产0.0786tLPG和联产电力607kWh.

  3. Soybean cultivar selection for Bioregenerative Life Support Systems (BLSS) - Theoretical selection (United States)

    De Micco, Veronica; Buonomo, Roberta; Paradiso, Roberta; De Pascale, Stefania; Aronne, Giovanna


    The development of plant-based Bioregenerative Life Support Systems (BLSS) is a requirement for the realization of long-duration exploratory-class manned missions in so far as they help fulfilling astronauts' needs including nutritional demands, air regeneration and psychological support. The program ESA - MELiSSA (European Space Agency - Micro-Ecological Life Support System Alternative) aims to conceive an artificial bioregenerative ecosystem based on both microorganisms and higher plants. Soybean is one of the four crops studied within this program as a candidate for cultivation in forthcoming BLSS. Within this project, the aim of this study was to develop a methodology for the selection of soybean candidate cultivars for BLSS. Our scope was to identify an objective and repeatable procedure to choose the best cultivar at each time, overcoming the variability of the market supply. This purpose was pursued with an approach based on a two-steps procedure: (a) the development of an objective criterion for the selection of the most suitable soybean cultivars (cultivated varieties) based on theoretical considerations and (b) the behaviour evaluation of the 4 best cultivars with a cultivation trial in a controlled environment. In this paper, we report the first phase of the selection procedure. We started with a literature survey to look for data about environmental needs, potential yields and nutritional traits of soybean cultivars already tested in cultivation trials (disregarding Gene Modified Organisms). Afterwards, a preliminary screening based on information about the main European companies and the most commercialized cultivars, as well as on the criteria suggested by ESA, allowed to select 93 cultivars among the 297 admitted in EU. Finally, an algorithm, based on the relevance of each considered characteristic, was created to attribute a score to each cultivar and to rank it for the identification of the best cultivars for subsequent cultivation trials.

  4. New genome sequence data and molecular tools promote the use of photosynthetic and edible cyanobacteria in bioregenerative systems to support human space exploration. (United States)

    Leys, Natalie; Morin, Nicolas; Janssen, Paul; Mergeay, Max

    Cyanobacteria are daily used as nutritional supplements (e.g. Spirulina) and are considered for promising applications beyond Earth, in space, where they can play a crucial role in closed miniaturised biological waste recycling systems that are currently developed to support future long-term space missions. Cyanobacteria can be cultured with artificial light in controllable photobioreactors, and used for the efficient removal of CO2 from and production of O2 in the at-mosphere of the confined spacecraft, for removal of nitrate from waste water that is recycled to potable water, and as complementary food source. In this context, the filamentous cyanobac-terium Arthrospira sp. PCC 8005 was selected as part of the bio-regenerative life-support system MELiSSA from the European Space Agency. For bioprocess control and optimisation, the access to its genetic information and the development of molecular tools is crucial. Here we report on our efforts to determine the full genome of the cyanobacterium Arthrospira sp. PCC 8005. The obtained sequence data were analysed in detail to gain a better insight in the photosynthetic, nutritive, or potential toxic potential of this strain. In addition, the sensitivity of PCC 8005 to ionizing radiation was investigated because prolonged exposure of PCC 8005 to cosmic radiation in space might have a deleterious effect on its metabolism and oxygenic properties. To our knowledge, of the 6 different research groups across the globe trying to sequence Arthrospira strains, none of them, including us, were yet able to obtain a complete genome sequence. For Arthrospira sp. strain PCC 8005, we obtained 119 contigs (assembled in 16 scaffolds), representing 6,3 Mb, with 5,856 predicted protein-coding sequences (CDSs) and 176 genes encoding RNA. The PCC 8005 genome displays an unusual high number of large repeated sequences, covering around 8% of the genome, which likely hampered the sequenc-ing. The PCC 8005 genome is also ridden by mobile

  5. A case study on the state–trait anxiety levels, general self-efficacy, and stress-control skills of undergraduate students having music educationMüzik eğitimi alan üniversite öğrencilerinin durumluk-sürekli kaygı düzeyleri, genel öz yeterlik ve stres kontrolü becerileri üzerine bir durum çalışması

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    Emre Üstün


    of individuals who didn’t have this education, that there was a positive effect of having the music education on individuals’ skills of self-efficacy and stress management, and that there was an improvement in those skills. It was also found that the music education has a significant impact on decreasing the state-trait anxiety levels, and increasing the self-efficacy and stress-management skills.   Özet İnsanlık tarih boyunca müziğin eğitici işlevine inanmış olup müziğe bir eğitim aracı olarak önemli bir yer ayırmıştır. Bireylerin başarılı olmalarını, hayal gücünü ve beyin gelişimini arttıran müzik eğitimi bireylere, topluma kazandıracağı olumlu niteliklerin verilmesini amaçlar. Eğitimin önemli bir boyutu olan müzik ile bireyler sadece bir alanda bilgilenmiş olarak değil, günümüz toplumlarının hızlı gelişimine de ayak uydurabilecek ve çok yönlü bireyler olarak yetişeceklerdir. Mesleki gelişim amacına ağırlık verilen günümüz üniversite eğitiminde akademik, kişisel ve sosyal yönleri ile çok yönlü bireyler yetiştirilmesi daha çok önem kazanmıştır. Müzik eğitimi, çok yönlü bireyler yetiştirilmesi anlayışına en uygun alanlardan birini oluşturmaktadır. Bilindiği gibi müzik bireysel, toplumsal, kültürel, ekonomik ve eğitimsel nitelikleri ile birçok işlevi olan çok yönlü bir olgudur. Bu yönleri ile bakıldığında müzik eğitimi vermeyi amaçlayan üniversitelerdeki uygulanan seçmeli müzik dersleri de öğrencilerin müziksel algılama yeteneğini ve müzik yaşamını yüksek düzeyde geliştirecektir. Bu durumdan yola çıkarak üniversitelerde verilen seçmeli müzik derslerinin bu dersi alan öğrenciler üzerinde kaygı, öz yeterlik ve stres durumlarında ki etkiyi ortaya çıkarması amaçlanmıştır. Üniversitesi programlarında yer alan seçmeli müzik derslerinin bu dersi alan öğrenciler üzerinde kaygı, genel öz yeterlik ve stres yönetimi d

  6. Water Treatment Unit Breadboard: Ground test facility for the recycling of urine and shower water for one astronaut (United States)

    Lindeboom, Ralph E. F.; Lamaze, Brigitte; Clauwaert, Peter; Christiaens, Marlies E. R.; Rabaey, Korneel; Vlaeminck, Siegfried; Vanoppen, Marjolein; Demey, Dries; Farinas, Bernabé Alonso; Coessens, Wout; De Paepe, Jolien; Dotremont, Chris; Beckers, Herman; Verliefde, Arne


    One of the major challenges for long-term manned Space missions is the requirement of a regenerative life support system. Average water consumption in Western Countries is >100 L d-1. Even when minimizing the amount of water available per astronauts to 13 L d-1, a mission of 6 crew members requires almost 30 ton of fresh water supplies per year. Note that the International Space Station (ISS) weighs approximately 400 ton. Therefore the development of an efficient water recovery system is essential to future Space exploration. The ISS currently uses a Vapor Compression Distillation (VCD) unit following the addition of chromic and sulphuric acid for the microbial stabilization of urine (Carter, Tobias et al. 2012), yielding a water recovery percentage of only 70% due to scaling control. Additionally, Vapor Compression Distillation of 1.5 L urine cap 1 d-1 has a significantly higher power demand with 6.5 W cap-1 compared to a combination of electrodialysis (ED) and reverse osmosis (RO) with 1.9 and 0.6 W cap-1 respectively (Udert and Wächter 2012). A Water Treatment Unit Breadboard (WTUB) has been developed which combines a physicochemical and biological treatment. The aim was to recover 90% of the water in urine, condensate and shower water produced by one crew member and this life support testbed facility was inspired by the MELiSSA loop concept, ESA's Life Support System. Our experimental results showed that: 1) using a crystallisation reactor prior to the nitrification reduced scaling risks by Ca2+- and Mg2+ removal 2) the stabilization of urine diluted with condensate resulted in the biological conversion of 99% of Total Kjeldahl nitrogen into nitrate in the biological nitrification reactor 3) salinity and nitrate produced could be removed by 60-80% by electrodialysis, 4) shower water contaminated with skin microbiota and Neutrogena soap ® could be mixed with electrodialysis diluate and filtered directly over a ceramic nanofiltration at 93% water recovery and 5

  7. Biological activity of Ruta chalepensis (Rutaceae and Sechium pittieri (Cucurbitaceae extracts on Hypsipyla grandella (Lepidoptera: Pyralidae larvae

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    Fernando Mancebo


    Full Text Available Biological activity of a plant extract (common rue, Ruta chalepensis and a semi purifíed fraction (from "tacaco cimarrón", Sechium pittieri on mahogany shootborer larvas (Hypsipyla grandella was studied. A randomized complete block design, with four replications, was used. H. grandella third instar larvas were exposed for 24 h to Cedrela odorata leaf discs dipped in several treatment dissolutions of each extract (0.1, 0.32, 1.0, 3.20, and 10%; afterwards, each larva was transferred to a flask containing an artificial diet and was allowed to complete its development. Variables measured included food consumption (foliar area eaten in 24 h, mortality, and developmental effects (developmental time for each larval instar and the pupa, and pupal weight. The common rue extract showed a clear antifeedant activity at a concentration as low as 0.32%, whereas the "tacaco cimarrón" fraction caused toxicity, especially at the two highest concentrations (3.20 and 10%.Se estudió la actividad biológica de un extracto de follaje de ruda (Ruta chalepensis y de una fracción semipurificada de "tacaco cimarrón" (Sechium pittieri sobre las larvas del gusano barrenador de las meliáceas (Hypsipyla grandella. Se utilizó un diseño de bloques completos al azar, con cuatro repeticiones. Durante 24 h se expusieron larvas de tercer estadio de H. grandella a discos de follaje de Cedrela odorata impregnados con cada tratamiento. Estos consistieron en disoluciones de cada extracto (0.1, 0.32, 1.0, 3.20 y 10%; posteriormente cada larva se transfirió a un frasco que contenía dieta artificial, donde se le permitió completar su desarrollo. Las variables de respuesta fueron el consumo de alimento (área foliar comida en 24 h, la mortalidad y efectos sobre el desarrollo (tiempo de desarrollo de cada estadio larval y de la pupa, y el peso de la pupa. El extracto de ruda causó fagodisuasión a una concentración de apenas 0.32%, mientras que la fracción de "tacaco cimarr

  8. Space Science is Alive with Art (United States)

    Pell, Sarah Jane; Vermeulen, Angelo


    The history of human space flight and analogue and ground-based space science is alive with art. Artists, scientists and engineers working together build upon diverse frameworks of understanding, but also share tools and processes of investigation. By jointly stepping into new worlds and territories - with common purpose and mutual respect for curiosity - there emerge opportunities for encounters that offer an alternative viewpoint on things. Artists can introduce a meta perspective (taking a step back and inquiring into the practice of research), a historical, conceptual or aesthetic view, all of which can invite those who are researchers, engineers and inventors toward new insight and discovery. Scientist’s methods of inquiry and their particular ways of dealing with natural phenomena and technology can also be a great source of inspiration for artists. Often with technical curiosity, artists can also contribute to concrete R&D just as science can directly impact art and inform aesthetics. So combined, the different philosophies, the experiments and the field work can lead to collaborative outcomes that are positively contributing to research, exploration and advancement. Artist and biologist Angelo Vermeulen has been working together with the European Space Agency (ESA) MELiSSA research program since 2009. In response to the ESA invitation to reflect on the development of future space habitats, Vermeulen set up SEAD (Space Ecologies Art & Design), a platform for artistic research on the transfer of terrestrial ecosystems to space to facilitate space settlement. Artist and diver Sarah Jane Pell has been working with the underwater technology and biotechnology community since 2003. She joined NASA’s Luna Gaia team and the League of New World Explorers analogue space subsea habitat exploration mission Atlantica in 2006. Current and future work by these, and similar partnerships, illustrates a dynamic culture of fieldwork, lab protocols/studio practice, research

  9. Productividad de lindero maderable de cedrela odorata1

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    Carlos J. Viera


    Full Text Available Productividad de lindero maderable de Cedrela odorata. Se estudió la producción de madera aserrada de linderos maderables sembrados en 1980 de Cedrela odorata con distanciamiento de 17 m entre plantas y sin ningún manejo. El estudio se llevó a cabo en el CIC-JAP La Fe, Ilama, Santa Bárbara a 750 msnm, 14° 59’ latitud norte y 88° 31’ longitud oeste, con precipitación promedio de 2.800 mm/año, los suelos son muy fértiles con alto contenido de bases cambiables, materia orgánica y micro nutrientes, no se presentan problemas de acidez, la topografía del terreno es inclinada con pendiente que varia de 10 a 20% aproximadamente. No se realizó un manejo agronómico a los árboles, por estar asociados con el cultivo de café, manejado técnicamente: prácticas de manejo de malezas y fertilización. Los IMA en altura y diámetros fueron de 1,09 m y 3,77 cm que se considera alto ya que es el promedio de 20 años, y una producción promedio por árbol de 596 pies tablar, para una proyección de un km de lindero con el distanciamiento del estudio, representaría un total de 35.164 pies tablar, con un ingreso bruto de Lps 316.476,00 a 386.804,00 de precio de madera puesta en finca (Lps 9.00 a 11,00 pies tablar que representa un ingreso extra sin afectar la producción de café, y aprovechar las calles internas con que cuenta la finca. Por la bifurcación que presentaron los árboles se dedujo que hubo ataque de barrenador de las meliáceas (Hypsipyla grandella Zeller.

  10. Frações de Trichilia pallens com atividade inseticida sobre Tuta absoluta Fractions of Trichilia pallens with insecticidal activity against Tuta absoluta

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    Uemerson Silva da Cunha


    Full Text Available Este trabalho teve o objetivo de identificar frações de extratos aquosos e orgânicos da meliácea Trichilia pallens, com atividade inseticida sobre a traça-do-tomateiro Tuta absoluta (Meyrick. Extratos aquosos liofilizados (EAL a 3% de folhas e ramos de T. pallens foram ressuspendidos em água e aplicados sobre folíolos de tomateiro infestados com lagartas recém-eclodidas. Com base na mortalidade aos 5 e 10 dias após a infestação (dai, os EAL de folhas foram mais eficientes que os de ramos. Numa segunda etapa, foram obtidos, por maceração, extratos de folhas a 1%, em hexano (HEX, diclorometano (DIC e metanol (MET como descrito anteriormente, tendo-se incluído acetona e água como controles. Entre os extratos, o DIC foi o mais promissor como fonte de substâncias com atividade inseticida sobre lagartas de T. absoluta. Na seqüência, por meio de partição líquido-líquido do extrato DIC de folhas, obtiveram-se as frações em HEX, MET, acetato de etila (AET, n-butanol (NBU e aquosa (AQ. Destas frações, a AQ a 0,1% do extrato em DIC foi considerada a mais promissora como fonte de substâncias com atividade inseticida sobre T. absoluta.This work aimed at identifying fractions of aqueous and organic extracts of the meliaceous Trichilia pallens with insecticidal activity against the tomato leafminer Tuta absoluta (Meyrick. Leaf and twig freeze-dried aqueous extracts (FDA of T. pallens were resuspended in water at a concentration of 3% and sprayed over tomato leaflets, which were infested with newly-hatched larvae. Larval mortality at 5 and 10 days after infestation (dai were higher for leaf extracts. In a second set of experiments, 1% leaf extracts were produced by maceration in hexane (HEX, dichloromethane (DIC and methanol (MET, and tested as described before, using acetone and water as controls. DIC extracts were the most promising as a source of substances with insecticidal activity against T. absoluta larvae, and were further

  11. 黄花草木樨对杂草的化感作用研究%The Allelopathy of Yellow Sweet Clover on Weeds

    Institute of Scientific and Technical Information of China (English)

    邬彩霞; 刘苏娇; 赵国琦; 徐俊


    为探讨黄花草木樨(Melilotus officinalis)水浸提液对田间常见杂草的化感抑制作用以及利用黄花草木樨化感作用进行生物除草的可行性,采用生物检测法研究黄花草木樨水浸提液对藜(Chenopodium album)、臭草(Meli-ca scabrosa)、籽粒苋(Amaranthush ypochondriacus)、稗草(Echinochloa crus-galli)、萹蓄(Pol ygonum aviculare)、山苦荬(Ixeris chinensis)、车前草(Plantago asiatica)等7种杂草种子萌发和幼苗生长的化感效应;同时测定黄花草木樨干草粉对田间杂草生物量的抑制效应.结果表明:黄花草木樨茎叶水浸提液处理能显著抑制籽粒苋、山苦荬、藜、稗草及车前草的种子萌发(P<0.05);能显著抑制藜、籽粒苋、稗草、山苦荬、车前草的幼苗生长(P<0.05);黄花草木樨干草粉能有效降低田间杂草生物量,且对田间杂草的抑制效应随施用量的增加而增强,在施用量达90g·m-2时,对田间杂草数量和干重的抑制均达到显著水平(P<0.05).因此,黄花草木樨的抑草能力具有选择性,对不同种杂草的作用方式和作用强度存在差异;黄花草木樨干草粉的施用量在90g·m-2及以上时,能显著降低田间杂草的数量及重量.

  12. Students’ perceptions about interactive white board used in physics classFizik dersinde öğrencilerin akıllı tahta kullanımı ile ilgili algıları

    Directory of Open Access Journals (Sweden)

    Cem Gürel


    Bu çalışmanın amacı ortaöğretim öğrencilerinin fizik dersinde akıllı tahtanın kullanımı ile ilgili algılarını ortaya koymaktır. Çalışmada Türkiye’nin Zonguldak ilindeki bir lisede Seçmeli Fizik dersini alan öğrencilerin bu derslerdeki akıllı tahta kullanımıyla ilgili algıları incelenmiştir. Çalıma, iki sınıfta akıllı tahta ile beyaz tahta-projeksiyon sistemlerinin kullanımlarının dönüşümlü olarak uygulanması şeklinde gerçekleştirilmiştir. Süreç ABAB modeli ile uygulanmış ve veriler nitel yöntem ve araçlar ile toplanmıştır. Çalışmada 16 kız ve 13 erkek olmak üzere toplam 29 öğrenciye uygulanan anketler ve derslerde tutulan günlükler ile elde edilen veriler kullanılmıştır. Günlük ve anketlerdeki sorular üç alanı ele almaktadır: (1 Faydalar, (2 Sınırlılıklar ve (3 Gelecek için tavsiyeler. Çalışmanın sonuçlarına göre, akıllı tahtanın çoklu ortam kullanımı ve çekici yönü ile öğrenciler tarafından ilgi uyarıcı bulunduğu ortaya çıkmıştır. Ayrıca, akıllı tahtanın gelecekteki kullanımları için tavsiyelerde de bulunulmuştur. Bu çalışmanın ortaya koyduğu verilerle eğitimciler akıllı tahtanın sınıflarda kullanımı ile ilgili bilgi edinebilecekler ve gelecekteki kullanıcılar akıllı tahta ile ilgili faydalı ipuçları bulabileceklerdir.

  13. Use of oral contraceptives in the management of acne

    Directory of Open Access Journals (Sweden)

    Melis GB


    Full Text Available Gian Benedetto Melis, Marisa Orrù, Maria Francesca Marotto, Monica Pilloni, Mariagrazia Perseu, Stefano Lello, Anna Maria PaolettiClinica Ginecologica Ostetrica e di Fisiopatologia della Riproduzione Umana, Universita' di Cagliari, Azienda Ospedaliero Universitaria di Cagliari, Cagliari, ItalyAbstract: The pathogenesis of acne (the most common disorder involving the sebaceous gland originates from increased sebum production by the sebaceous gland followed by colonization of the hair follicle with Propionibacterium acnes, hyperkeratinization of the upper follicle, and release of inflammatory mediators into the skin. Androgens are the main stimulators of sebum production. Androgens originate from the gonads and adrenal glands, but can also be locally produced within the sebaceous gland from dehydroepiandrosterone sulfate. In the presence of high androgen levels, which can be either a normal pattern of adolescence or a consequence of gonadal or adrenal disease, overproduction of sebum triggers the pathogenesis of acne which, mainly in adolescent women, has deleterious psychological consequences. Estrogens exert the opposite action on sebum production, probably due to the reduction of androgen availability, a direct consequence of estrogen-related increased production of hepatic sex hormone-binding globulin (SHBG. The inhibition of the hypothalamus-pituitary axis induced by oral contraceptives is followed by reduced androgen production. Oral contraceptives containing ethinyl estradiol, which has strong estrogenic activity, amplify the hypoandrogenic effect via estrogen-related stimulation of SHBG. The hypoandrogenic effect of oral contraceptives is modulated by the progestin compound. Progestins derived from 19-nortestosterone bind androgenic receptors, whereas others exert antiandrogenic properties by antagonizing the binding of androgens to their receptors, reduce 5α-reductase, and do not bind SHBG. Through this last effect, SHBG is freely

  14. Preliminary results of Physiological plant growth modelling for human life support in space (United States)

    Sasidharan L, Swathy; Dussap, Claude-Gilles; Hezard, Pauline


    Human life support is fundamental and crucial in any kind of space explorations. MELiSSA project of European Space Agency aims at developing a closed, artificial ecological life support system involving human, plants and micro organisms. Consuming carbon dioxide and water from the life support system, plants grow in one of the chambers and convert it into food and oxygen along with potable water. The environmental conditions, nutrient availability and its consumption of plants should be studied and necessarily modeled to predict the amount of food, oxygen and water with respect to the environmental changes and limitations. The reliability of a completely closed system mainly depends on the control laws and strategies used. An efficient control can occur, only if the system to control is itself well known, described and ideally if the responses of the system to environmental changes are predictable. In this aspect, the general structure of plant growth model has been designed together with physiological modelling.The physiological model consists of metabolic models of leaves, stem and roots, of which concern specific metabolisms of the associated plant parts. On the basis of the carbon source transport (eg. sucrose) through stem, the metabolic models (leaf and root) can be interconnected to each other and finally coupled to obtain the entire plant model. For the first step, leaf metabolic model network was built using stoichiometric, mass and energy balanced metabolic equations under steady state approach considering all necessary plant pathways for growth and maintenance of leaves. As the experimental data for lettuce plants grown in closed and controlled environmental chambers were available, the leaf metabolic model has been established for lettuce leaves. The constructed metabolic network is analyzed using known stoichiometric metabolic technique called metabolic flux analysis (MFA). Though, the leaf metabolic model alone is not sufficient to achieve the

  15. Selection and hydroponic growth of bread wheat cultivars for bioregenerative life support systems (United States)

    Page, V.; Feller, U.


    As part of the ESA-funded MELiSSA program, the suitability, the growth and the development of four bread wheat cultivars were investigated in hydroponic culture with the aim to incorporate such a cultivation system in an Environmental Control and Life Support System (ECLSS). Wheat plants can fulfill three major functions in space: (a) fixation of CO2 and production of O2, (b) production of grains for human nutrition and (c) production of cleaned water after condensation of the water vapor released from the plants by transpiration. Four spring wheat cultivars (Aletsch, Fiorina, Greina and CH Rubli) were grown hydroponically and compared with respect to growth and grain maturation properties. The height of the plants, the culture duration from germination to harvest, the quantity of water used, the number of fertile and non-fertile tillers as well as the quantity and quality of the grains harvested were considered. Mature grains could be harvested after around 160 days depending on the varieties. It became evident that the nutrient supply is crucial in this context and strongly affects leaf senescence and grain maturation. After a first experiment, the culture conditions were improved for the second experiment (stepwise decrease of EC after flowering, pH adjusted twice a week, less plants per m2) leading to a more favorable harvest (higher grain yield and harvest index). Considerably less green tillers without mature grains were present at harvest time in experiment 2 than in experiment 1. The harvest index for dry matter (including roots) ranged from 0.13 to 0.35 in experiment 1 and from 0.23 to 0.41 in experiment 2 with modified culture conditions. The thousand-grain weight for the four varieties ranged from 30.4 to 36.7 g in experiment 1 and from 33.2 to 39.1 g in experiment 2, while market samples were in the range of 39.4-46.9 g. Calcium levels in grains of the hydroponically grown wheat were similar to those from field-grown wheat, while potassium, magnesium

  16. The influence of age on health valuations: the older olds prefer functional independence while the younger olds prefer less morbidity

    Directory of Open Access Journals (Sweden)

    Hofman CS


    Full Text Available Cynthia S Hofman,1,2 Peter Makai,1 Han Boter,3 Bianca M Buurman,4 Anton J de Craen,5 Marcel GM Olde Rikkert,1 Rogier Donders,2 René JF Melis1 1Department of Geriatric Medicine, Radboud University Medical Center, Nijmegen, the Netherlands; 2Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands; 3Department of Epidemiology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; 4Department of Internal Medicine, Section of Geriatric Medicine, Academic Medical Center, Amsterdam, the Netherlands; 5Department of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, the Netherlands Background: To assess the effectiveness of geriatric interventions, The Older Persons and Informal Caregivers Survey – Composite Endpoint (TOPICS-CEP has been developed based on health valuations of older persons and informal caregivers. This study explored the influence of the raters’ age on the preference weights of TOPICS-CEP’s components.Methods: A vignette study was conducted with 200 raters (mean age ± standard deviation: 72.5±11.8 years; 66.5% female. Profiles of older persons were used to obtain the preference weights for all TOPICS-CEP components: morbidity, functional limitations, emotional wellbeing, pain experience, cognitive functioning, social functioning, self-perceived health, and self-perceived quality of life. The raters assessed the general wellbeing of these vignettes on a 0–10 scale. Mixed linear regression analysis with interaction terms was used to explore the effects of raters’ age on the preference weights.Results: Interaction effects between age and the TOPICS-CEP components showed that older raters gave significantly (P<0.05 more weight to functional limitations and social functioning and less to morbidities and pain experience, compared to younger raters.Conclusion: Researchers examining effectiveness in elderly care need to consider the

  17. Diffuse volcanic degassing and thermal energy release 2015 surveys from the summit cone of Teide volcano, Tenerife (Canary Islands, Spain) (United States)

    Melián, Gladys; Asensio-Ramos, María; Padilla, Germán; Alonso, Mar; Halliwell, Simon; Sharp, Emerson; Butters, Damaris; Ingman, Dylan; Alexander, Scott; Cook, Jenny; Pérez, Nemesio M.


    The summit cone of Teide volcano (Spain) is characterized by the presence of a weak fumarolic system, steamy ground, and high rates of diffuse CO2 degassing all around this area. The temperature of the fumaroles (83° C) corresponds to the boiling point of water at discharge conditions. Water is the major component of these fumarolic emissions, followed by CO2, N2, H2, H2S, HCl, Ar, CH4, He and CO, a composition typical of hydrothermal fluids. Previous diffuse CO2 surveys have shown to be an important tool to detect early warnings of possible impending volcanic unrests at Tenerife Island (Melián et al., 2012; Pérez et al., 2013). In July 2015, a soil and fumarole gas survey was undertaken in order to estimate the diffuse volcanic degassing and thermal energy release from the summit cone of Teide volcano. A diffuse CO2 emission survey was performed selecting 170 observation sites according to the accumulation chamber method. Soil CO2 efflux values range from non-detectable (˜0.5 g m-2d-1) up to 10,672 g m-2d-1, with an average value of 601 g m-2d-1. Spatial distribution maps were constructed following the sequential Gaussian simulation (sGs) procedure. Measurement of soil CO2 efflux allowed an estimation of 162 ± 14 t d-1 of deep seated derived CO2. To calculate the steam discharge associated with this volcanic/hydrothermal CO2 output, we used the average H2O/CO2 mass ratio equal to 1.19 (range, 0.44-3.42) as a representative value of the H2O/CO2 mass ratios for Teide fumaroles. The resulting estimate of the steam flow associated with the gas flux is equal to 193 t d-1. The condensation of this steam results in a thermal energy release of 5.0×1011J d-1 for Teide volcano or a total heat flow of 6 MWt. The diffuse gas emissions and thermal energy released from the summit of Teide volcano are comparable to those observed at other volcanoes. Sustained surveillance using these methods will be valuable for monitoring the activity of Teide volcano.

  18. A hybridized membrane-botanical biofilter for improving air quality in occupied spaces (United States)

    Llewellyn, David; Darlington, Alan; van Ras, Niels; Kraakman, Bart; Dixon, Mike

    number of space-specific applications such as odors arising from aspects of the MELiSSA system and spacequalified small animal cages, our focus was on indoor air quality as the terrestrial application of this technology. This paper describes aspects of the development of this technology from conceptualization through laboratory trials to the design, construction and field trials of pre-market prototypes.

  19. Abundance Trends and Status of the Little Colorado River Population of Humpback Chub: An Update Considering Data From 1989-2008 (United States)

    Coggins,, Lewis G.; Walters, Carl J.


    Mark-recapture methods have been used for the past two decades to assess trends in adult abundance and recruitment of the Little Colorado River (LCR) population of humpback chub. These methods indicate that the adult population declined through the 1980s and early 1990s but has been increasing for the past decade. Recruitment appears also to have increased, particularly in the 2003-4 period. Considering a range of assumed natural mortality-rates and magnitude of ageing error, it is unlikely that there are currently less than 6,000 adults or more than 10,000 adults. Our best estimate of the current adult (age 4 years or more) population is approximately 7,650 fish. Recent humpback chub assessments using the Age-Structured Mark-Recapture model (ASMR) and reported in 2006 (Melis and others, 2006) and 2008 (Coggins, 2008a,b) have provided abundance and recruitment trend estimates that have changed progressively over time as more data are considered by the model. The general pattern of change implies a less severe decline in adult abundance during the late 1980s through early 1990s, with attendant changes in recruitment supporting this demographic pattern. We have been concerned that these changes are not indicative of the true population and may be associated with a 'retrospective' bias as additional data are included in the ASMR model. To investigate this possibility, we developed a realistic individual-based simulation model (IBM) to generate replicate artificial data sets with similar characteristics to the true humpback chub data. The artificial data have known abundance trends and we analyzed these data with ASMR. On the basis of these simulations, we believe that errors in assigning age (and therefore brood-year) to fish based on their length are likely to have caused the retrospective bias pattern seen in the assessments and to have caused both less severe trends in the adult abundance estimates and progressively more severe downward bias in estimates of adult

  20. Canadian advanced life support capacities and future directions (United States)

    Bamsey, M.; Graham, T.; Stasiak, M.; Berinstain, A.; Scott, A.; Vuk, T. Rondeau; Dixon, M.


    Canada began research on space-relevant biological life support systems in the early 1990s. Since that time Canadian capabilities have grown tremendously, placing Canada among the emerging leaders in biological life support systems. The rapid growth of Canadian expertise has been the result of several factors including a large and technically sophisticated greenhouse sector which successfully operates under challenging climatic conditions, well planned technology transfer strategies between the academic and industrial sectors, and a strong emphasis on international research collaborations. Recent activities such as Canada's contribution of the Higher Plant Compartment of the European Space Agency's MELiSSA Pilot Plant and the remote operation of the Arthur Clarke Mars Greenhouse in the Canadian High Arctic continue to demonstrate Canadian capabilities with direct applicability to advanced life support systems. There is also a significant latent potential within Canadian institutions and organizations with respect to directly applicable advanced life support technologies. These directly applicable research interests include such areas as horticultural management strategies (for candidate crops), growth media, food processing, water management, atmosphere management, energy management, waste management, imaging, environment sensors, thermal control, lighting systems, robotics, command and data handling, communications systems, structures, in-situ resource utilization, space analogues and mission operations. With this background and in collaboration with the Canadian aerospace industry sector, a roadmap for future life support contributions is presented here. This roadmap targets an objective of at least 50% food closure by 2050 (providing greater closure in oxygen, water recycling and carbon dioxide uptake). The Canadian advanced life support community has chosen to focus on lunar surface infrastructure and not low Earth orbit or transit systems (i.e. microgravity

  1. Mobil tabanlı optik form değerlendirme sistemi

    Directory of Open Access Journals (Sweden)

    Asım Sinan YÜKSEL


    Full Text Available Ülkemizde ve dünyadaki eğitim sistemlerinde gerek öğrencilerin başarılarının değerlendirilmesinde gerekse öğrenci seçiminde çoktan seçmeli şıklar içeren optik formlar çok sık kullanılmaktadır. Optik formlar optik okuyucu cihazlar sayesinde optik işaret tanıma teknikleri kullanılarak değerlendirilmektedir. Bu tip cihazların pahalı olması, bu cihazlara erişimin sınırlı olması ve değerlendirme sonuçlarını bekleme süresinin uzun olması hem büyük şehirlerde hem de taşrada çalışan eğitimcilere zorluk çıkarmaktadır. Bu çalışmada eğitimcilerin sahip oldukları akıllı telefon ya da tabletleri aracılığı ile bir mekâna ya da optik cihaza bağlı kalmadan, hızlı bir şekilde öğrenci cevap formlarını değerlendirebilecekleri mobil bir yazılım geliştirilmiştir. Optik form tanıma, okuma ve değerlendirme işlemi eğitimcinin mobil telefonu ya da tableti aracılığı ile çektiği öğrencinin cevap formu görüntüsü üzerinde yapılmaktadır. Geliştirdiğimiz Android tabanlı mobil uygulama kullanıcı dostu bir arayüze sahip olup başarı oranı yüksektir ve bu alanda mobil ortamlarda çalışan ilk uygulama olma özelliğini taşımaktadır.

  2. Selection and hydroponic growth of potato cultivars for bioregenerative life support systems (United States)

    Molders, K.; Quinet, M.; Decat, J.; Secco, B.; Dulière, E.; Pieters, S.; van der Kooij, T.; Lutts, S.; Van Der Straeten, D.


    As part of the ESA-funded MELiSSA program, Ghent University and the Université catholique de Louvain investigated the suitability, growth and development of four potato cultivars in hydroponic culture under controlled conditions with the aim to incorporate such cultivation system in an Environmental Control and Life Support System (ECLSS). Potato plants can fulfill three major functions in an ECLSS in space missions: (a) fixation of CO2 and production of O2, (b) production of tubers for human nutrition and (c) production of clean water after condensation of the water vapor released from the plants by transpiration. Four cultivars (Annabelle, Bintje, Desiree and Innovator) were selected and grown hydroponically in nutrient film technique (NFT) gullies in a growth chamber under controlled conditions. The plant growth parameters, tuber harvest parameters and results of tuber nutritional analysis of the four cultivars were compared. The four potato cultivars grew well and all produced tubers. The growth period lasted 127 days for all cultivars except for Desiree which needed 145 days. Annabelle (1.45 kg/m2) and Bintje (1.355 kg/m2) were the best performing of the four cultivars. They also produced two times more tubers than Desiree and Innovator. Innovator produced the biggest tubers (20.95 g/tuber) and Desiree the smallest (7.67 g/tuber). The size of Annabelle and Bintje potatoes were intermediate. Bintje plants produced the highest total biomass in term of DW. The highest non-edible biomass was produced by Desiree, which showed both the highest shoot and root DW. The manual length and width measurements were also used to predict the total tuber mass. The energy values of the tubers remained in the range of the 2010 USDA and Souci-Fachmann-Kraut food composition databases. The amount of Ca determined was slightly reduced compared to the USDA value, but close to the Souci-Fachmann-Kraut value. The concentration of Cu, Zn and P were high compared to both databases

  3. Resim-İş Eğitimi Anabilim Dalı Atölye (Grafik Dersinde Yazı ve Tipografi Öğretimi Uygulamaları / Practices of Writing and Typography Teaching at the Department of Fine Arts Education Workshop (Graphic Design Course

    Directory of Open Access Journals (Sweden)

    Şirin BENUĞUR


    Full Text Available Bu araştırmanın amacı, Eğitim Fakültesi Güzel Sanatlar Eğitimi Bölümü Resim İş Eğitimi ABD Anasanat Atölye (Grafik ve/veya Seçmeli Sanat Atölye (Grafik derslerinde tipografi eğitiminin nasıl gerçekleştirildiğini ortaya koymaktır. Araştırma tarama modelinde desenlenmiştir. Hazırlanan anket, 2007-2008 öğretim yılının bahar döneminde 24 üniversitede bu dersi veren/vermiş olan 45 öğretim elemanına uygulanmıştır. Ayrıca çalışma evreninden 7 öğretim elemanıyla yarı yapılandırılmış görüşme gerçekleştirilmiştir. Araştırma sonucunda sanat eğitimcisi yetiştirmede tipografi eğitiminin çok önemli ve gerekli olduğu, tipografi öğretimini planlarken farklı konu ve tekniklerden yararlanılarak uygulama yapılmasına, kuramsal bilgi vermeye, proje çalışmaları yaptırmaya, örneklerle konuyu açıklamaya, çesitli öğretim yöntem ve tekniklerinden yararlanmaya, tipografi öğretimini desteklemeye yönelik çeşitli etkinlikler gerçekleştirmeye önem verildiği belirlenmiştir. Tipografi öğretiminde öğrenciden, kaynak kitap ve ders saati süresinin yetersizliğinden kaynaklanan sorunlar yaşandığı belirlenmiştir. Yazı dersinin tipografi öğretimine temel oluşturacağını ifade eden öğretim elemanları, dersin içeriğinin alan uzmanları tarafından zenginleştirilmesine, ders süresinin arttırılmasına ve tipografi dersleriyle desteklenmesine yönelik önerilerde bulunmuşlardır.

  4. Encapsulation of hydride by molecular main group metal clusters: manipulating the source and coordination sphere of the interstitial ion. (United States)

    Boss, Sally R; Coles, Martyn P; Eyre-Brook, Vicki; García, Felipe; Haigh, Robert; Hitchcock, Peter B; McPartlin, Mary; Morey, James V; Naka, Hiroshi; Raithby, Paul R; Sparkes, Hazel A; Tate, Christopher W; Wheatley, Andrew E H


    The sequential treatment of Lewis acids with N,N'-bidentate ligands and thereafter with ButLi has afforded a series of hydride-encapsulating alkali metal polyhedra. While the use of Me3Al in conjunction with Ph(2-C5H4N)NH gives Ph(2-C5H4N)NAlMe2 and this reacts with MeLi in thf to yield the simple 'ate complex Ph(2-C5H4N)NAlMe3Li.thf, the employment of an organolithium substrate capable of beta-hydride elimination redirects the reaction significantly. Whereas the use of ButLi has previously yielded a main group interstitial hydride in which H- exhibits micro6-coordination, it is shown here that variability in the coordination sphere of the encapsulated hydride may be induced by manipulation of the organic ligand. Reaction of (c-C6H11)(2-C5H4N)NH with Me3Al/ButLi yields [{(c-C6H11)(2-C5H4N)N}6HLi8]+[(But2AlMe2)2Li]-, which is best viewed as incorporating only linear di-coordination of the hydride ion. The guanidine 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine (hppH) in conjunction with Me2Zn/ButLi yields the micro8-hydride [(hpp)6HLi8]+[But3Zn]-.0.5PhMe. Formation of the micro8-hydride [(hpp)6HLi8]+[ButBEt3]- is revealed by employment of the system Et3B/ButLi. A new and potentially versatile route to interstitial hydrides of this class is revealed by synthesis of the mixed borohydride-lithium hydride species [(hpp)6HLi8]+[Et3BH]- and [(hpp)6HLi8]+[(Et3B)2H]- through the direct combination of hppLi with Et3BHLi.

  5. Negatywna seksualność jako bierna postawa społeczna

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    Marta Płonecka


    oporu wobec władzy nad ludzką seksualnością. Opisuję zjawisko biooporu i uwalniania cielesności na przykładzie pracy Krzysztofa Pacewicza o teoriach Michela Foucaulta i Giorgio Agambena. Analizuję kondycję edukacji seksualnej i ruchów antydyskryminacyjnych w Polsce w czasie teraźniejszym. Moja praca ma pokazać, że sekspozytywna postawa życiowa, czyli akceptacja siebie i innych oraz tworzenie bezprzemocowej przestrzeni umożliwia powszechną samoakceptację i samorozwój. Jest jednocześnie aktywną postawą społeczną, ponieważ wymaga zaangażowania intelektualnego i politycznego we wpływaniu na zastaną rzeczywistość. Uważam, że pozytywna seksualność, wspierana pozytywną edukacją seksualną i zaangażowaniem społecznym, to bardzo istotny element oporu wobec relacji władzy.

  6. Segnalazioni/Informes/Rapports/Reports

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    Emanuele Monegato


    , Barcelona, Anagrama, 2012, 434 pp. ISBN 978-84-339-2597-8 José “Cheche” Campos Dávila, Ajum decía mi abuela , Lima, Editorial San Marcos, 2011, 199 pp. ISBN 978-612-302-676-9 Joseph Gelfer (ed., 2012 Decoding the Countercultural Apocalypse, Oakville and Sheffield, Equinox Publishing Ltd, 2011, 203 pp ISBN 978-1-84553-639-8 Juan Pablo Sutherland, Cielo dandi. Escrituras y poéticas de estilo en América latina, Buenos Aires, Eterna Cadencia, 2011, 284 pp. ISBN 978-987-1673-46-9 Luigi Cimmino, Daniele Dottorini, Giorgio Pangaro, Dal cuore di tenebra all'Apocalisse. Francis Ford Coppola legge Joseph Conrad, Soveria Mannelli, Rubbettino Editore, 2011, 205 pp. ISBN 978-884-982-907-5 Mariacristina Cavecchi, Cerchi e cicli: sulle forme della memoria in Ulisse, Piccola Biblioteca Joyciana, Roma, Bulzoni, 2012, 96 pp. ISBN 978-88-7870-723-8 Mauro Giori (ed., Poetica e prassi della trasgressione in Luchino Visconti. 1935-1962 , Milano, Lampi di stampa, 2011, 346 pp. ISBN 978-88-488-1277-1 Michela Bassanelli e Gennaro Postiglione (eds., The Atlantikwall As Military Archeological Landscape / L’Atlantikwall come paesaggio di archeologia militare , Siracusa, LetteraVentidue, 2011, 207 pp. ISBN 978-88-6242-041-9 Neil Campbell e Alasdair Kean (eds., American Cultural Studies. An Introduction to American Culture , London, Routledge, 2011, 376 pp. ISBN 978-0-415-59871-2 Silvia Antosa (ed., Queer Crossings. Theories, Bodies, Texts , Milano Mimesis, 2012, 195 pp. ISBN 978-885-750-939-6 Silvia Antosa, Crossing Boundaries: Bodily Paradigms in Jeanette Winterson's Fiction . 1985-2000 , Roma, Aracne, 2008, 224 pp. ISBN 978-885-481-682-4 Silvia Gianni, Tendenze della critica letteraria e narrativa centroamericana degli ultimi anni , Roma, Aracne editrice, 2011, 361 pp. ISBN 978-88-548-4027-0 Silvia Ross, Tuscan Spaces. Literary Contstructions of Place, Toronto/Buffalo/London, University of Toronto Press, 2010, 224 pp. ISBN 978-1-4426-3998-0 Valentina Agostinis, Londra chiama. Otto


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    ştırmacının hazırladığı yarı yapılandırılmış görüşme formuyla elde edilmiş, NVivo 8 nitel veri analizi programıyla çözümlenmiştir. Çalışma sonucunda öğretmenlerin en fazla geleneksel yöntemlerden yazılı sınav, tamamlama-boşluk doldurma, çoktan seçmeli, doğru-yanlış türü ve eşleştirme sorularını; tamamlayıcı yöntemlerden ise performansa dayalı işlemler, projeler ve ürün seçki dosyasını kullandıkları belirlenmiştir. Yazılı sınav türünde öğrencilerin bildiklerini ifade edememeleri, tamamlama sorularında öğrencinin akıllarına geleni yazmaları, çoktan seçmeli, doğru yanlış ve eşleştirme sorularında ise öğrencilerin şansla doğru cevabı bulmaları gibi sorunların olduğu tespit edilmiştir. Performansa dayalı işlemler ve proje yöntemindeyse öğretmenler öğrencilerin ödevleri internetten hazır alma, ailelerden fazla yardım görme ve özgün bir ürün ortaya koyamama sorunuyla karşılaştıklarını belirtmişlerdir.Measurement and assessment methods, difficulties Ölçme-değerlendirme yöntemleri, karşılaşılan güçlükler.

  8. Selected Abstracts of the 10th International Workshop on Neonatology; Cagliari (Italy; October 22-25, 2014

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    --- Various Authors


    (Italy ABS 9. Traffiking of thymosin beta-4 in the cellular compartments of HepG2 cells at different conditions • M. Piras, M. Piludu, G. Pichiri, P. Coni, T. Cabras, R. Ambu, M. Castagnola; Cagliari and Rome (Italy ABS 10. Thyroid carcinoma in sardinian children and adolescents is often associated with autoimmune thyroiditis • P. Coni, E. Tamponi, A. Lampis, G. Pinna, A.M. Nurchi, S. Farci, M.L. Lai; Cagliari (Italy ABS 11. Prolonging nephrogenesis in preterm infants: a new approach for the prevention of renal disease in adulthood? • A. Sanna, C. Gerosa, D. Fanni, P. Van Eyken, M. Castagnola, R. Ambu; Cagliari, Rome (Italy and Leuven (Belgium ABS 12. Human adrenal gland development: morphogenesis and molecular mechanisms • E. Obinu, V. Fanos, A. Dessì, R. Ambu; Cagliari (Italy ABS 13. Biometrics application for newborns safe identification in Neonatal Intensive Care Units • A. Casanova, S. Barra, M. De Marsico, D. Riccio, L. Barberini, M. Puddu, V. Fanos; Cagliari, Rome and Naples (Italy ABS 14. Metabolomics in neonatal hypoxic-ischemic encephalopathy (HIE: a proposal for a european multicenter study • P. Gancia, G. Pomero, A. Delogu, C. Dalmazzo, G. Palmas, V. Fanos; Cuneo and Cagliari (Italy ABS 15. Longitudinal evaluation of myocardial function in infants with Hypoxic-Ischemic Encephalopathy (HIE: preliminary data • F. Vitali, S. Galletti, A. Aceti, L. Ridolfi, G. Aquilano, M. Fabi, G. Faldella; Bologna (Italy ABS 16. Changes in podocyte number during intrauterine development • M. Desogus, A. Crobe, A. Sanna, C. Gerosa, C. Fanni, C. Loddo, M. Puddu, G. Ottonello, D. Fanni; Cagliari (Italy ABS 17. Efficacy of recombinant human erythropoietin in anemic pregnant women with heterozygous beta-thalassemia • S. Angioni, V. Mais, G.B. Melis; Cagliari (Italy ABS 18. WT1 expression in ontogenesis of human fetus • R. Ambu, L. Vinci, C. Gerosa, D. Fanni, E. Obinu, A. Faa, V. Fanos; Cagliari (Italy ABS 19. Brain hypothermia in perinatal arterial ischemic

  9. Quel mode de liaison dans les corrélatives isomorphes « » et « autant...autant » ?

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    Roig Audrey


    Full Text Available Le débat sur l’identification du mode de liaison de prédications dans les structures corrélatives isomorphes (CI du type plus…plus et autant…autant a fait couler beaucoup d’encre ces vingt à trente dernières années. La question, semblerait-il, a aujourd’hui trouvé autant de réponses qu’il existe de solutions sensées : ainsi, si la liaison prédicationnelle est de nature subordonnante selon Riegel et alii (2004, Den Dikken (2005 et Stage (2009, elle a plus volontiers trait à la coordination pour Melis (1994, Muller (2008, Grevisse & Goosse (2011 ou Mouret (2013. Ces constructions témoigneraient plutôt de la possibilité de dissocier les composantes sémantique et syntaxique des structures langagières de l’avis d’Allaire (1982 ou Culicover & Jackendoff (1997, 1999, dans la mesure où elles se caractériseraient par la présentation d’une coordination syntaxique doublée d’une subordination sémantique. Ces trois options, contraires mais relayées chacune par une série d’arguments, conduisent notamment Abeillé & Borsley (2006 à admettre la coexistence de deux analyses en français, quand seule l’option de la liaison par subordination doit être retenue pour les CI en anglais. La complexité de trancher la question de l’identification du mode de liaison à l’œuvre dans les CI si l’on s’en tient à une typologie traditionnelle des jonctions prédicationnelles, a déjà été mise en évidence par des auteurs comme Abeillé & Borsley (2006 ou Hadermann et alii (2010, notamment. La résolution du problème de catégorisation des CI dans une appréhension plus classique des modes de liaison (subordination vs coordination reste pourtant possible, selon nous, mais elle suppose la réponse préalable, en amont, à un autre débat qui anime depuis longtemps les syntacticiens, à savoir celui de la définition du système organisant les jonctions prédicationnelles (section 2 : par exemple, qu’est-ce que la


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    İbrahim KARAHANCİ


    Full Text Available Bilimsel bir araştırma için vazgeçilmez olan nesnellik, akademik üslup çalışmalarını yakından ilgilendirmektedir. Dil bilimi, sistemli inceleme düzlem ve yöntemleriyle bu nesnelliği oluşturabilir. Belirli sıklık, dağılım ve birleşimler sonucunda oluşan üslup, özellikle sözcük ve cümle düzeyinde belirginleşmektedir. Bu dil birimleri, dilin mevcut olanakları içinde tercihe açıklık ve seçmeli dil değişkenliği göstermesi açısından zengin malzeme içeriğine sahiptir ve eserde yansıtılan özgün yapıyı -üslubu- doğrudan etkilemektedirler. Sözcük bilgisinin alt inceleme birimlerinden adlar ve sıfatlar, yaygın kullanım alanlarıyla önemli üslup belirleyicileri olarak öne çıkmaktadır. Adlarda özel / cins, tekil / çoğul / topluluk, soyut / somut / iş- oluş; sıfatlarda niteleme ve belirtme (gösterme özellikleri işlevsel ve kategorik inceleme alanları oluştururlar. Bunların metin bağlamında değerlendirilip sayısal verilerin somut aracılıklarıyla yorumlanması kapsamlı üslup tasviri için önemlidir. / The objectivity that is indispensable for a scientific research is closely related to academic style studies. Linguistics, with its systematic levels and methods can create this objectivity. The style that occurs as a result of certain frequencies, distributions and combinations become especially evident at the level of words and sentences. These language units have rich material content in terms of its preference for openness and selective language variability within the available possibilities of language, and directly influencing the originality of the author's work, style. Nouns and adjectives of sub-study units of lexicology stand out as important stylists with their widespread use. The features of nouns proper / common, singular / plural, collective, abstract / concrete, action-process; of adjectives qualification and assertion (representation form functional and categorical

  11. Occurrence of silicate melt, carbonate-rich melt and fluid during medium pressure anatexis of metapelitic gneisses (Oberpfalz, Bavaria) revealed by melt and fluid inclusions study (United States)

    Ferrero, Silvio; O'Brien, Patrick; Hecht, Lutz; Wunder, Bernd


    of a silicate melt and a carbonate-rich melt during anatexis at relatively shallow crustal levels, but this hypothesis needs to be further tested through re-homogenization experiments by piston cylinder means. References Bartoli, O., Cesare, B., Poli, S., Bodnar, R.J., Acosta-Vigil, A., Frezzotti, M.L. & Meli, S., 2013. Recovering the composition of melt and the fluid regime at the onset of crustal anatexis and S-type granite formation. Geology, 41, 115-118. Cesare, B., Ferrero, S., Salvioli-Mariani, E., Pedron, D. & Cavallo, A., 2009. Nanogranite and glassy inclusions: the anatectic melt in migmatites and granulites. Geology, 37, 627-630. Ferrero, S., Bartoli, O., Cesare, B., Salvioli Mariani, E., Acosta-Vigil, A., Cavallo, A., Groppo, C. & Battiston, S., 2012. Microstructures of melt inclusions in anatectic metasedimentary rocks. Journal of Metamorphic Geology, 30, 303-322. Ferrero, S., Braga, R., Berkesi, M., Cesare, B. & Laridhi Ouazaa, N., 2014. Production of Metaluminous melt during fluid-present anatexis: an example from the Maghrebian basement, La Galite Archipelago, central Mediterranean. Journal of Metamorphic Geology, DOI:10.1111/jmg.12068. Tanner, D.C. & Behrmann, J.H., 1995. The Variscan tectonics of the Moldanubian gneisses, Oberpfalzer Wald: a compressional history. Neues Jahrbuch fur Geologie und Palaontologie. Abhandlungen, 197, 331-355. Touret, J.L.R., 2009. Mantle to lower-crust fluid/melt transfer through granulite metamorphism. Russian Geology and Geophysics, 50, 1052-1062.

  12. Satisfacción Laboral en Profesionales de Enfermería

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    Sonia Solano Aguilar


    Full Text Available Introducción: El objetivo principal de la investigación fue describir el grado de satisfacción laboral de las Enfermeras de Clínicas y Hospitales de Bucaramanga y área Metropolitana, para ello se identificaroncaracterísticas sociodemográficas, y características laborales del personal de enfermería. Materiales y Métodos : Se trato de un estudio descriptivo multicéntrico cuya muestra la conformaron 218 enfermeras que laboran en el sector público y privado de las Clínicas y Hospitales de Bucaramanga y su área Metropolitana. Se aplicó el cuestionario de satisfacción laboral S10/12 de J.L Meliá y J.M.Peiro (1998 modificado para incluir algunos aspectos descriptivos y factores intrínsecos de la teoría de Herzberg. Resultados: En cuanto al nivel educativo un gran porcentaje el 47.2% no ha realizado ningún tipo de estudio complementario al de su pregrado, el 25.7% ha realizado alguna especialización y el 24.8% diplomado; además solo el 1.8% ha realizado maestría y el 0.5% tiene doctorado. En el 67.9% la categoría laboral es general y el 27.5% es especialista. En cuanto a la jerarquía el 88.1% laboran como enfermeras de servicio y el 0.9% ejercen labores de supervisión. Los resultados también demuestran que los factores de ambiente y supervisión están dentro de una media del 5.2 y una desviación estándar de 1.3 lo que equivale a decir que las enfermeras están satisfechas; por otro lado el factor que genera mayor inconformidad es el de las prestaciones sociales con una media de 4.7 y una desviación estándar de 1.6. Discusión y Conclusiones: Los resultados del estudio en su mayoría de ítem demuestran que las personas están satisfechas, sin embargo a pesar de esto llama la atención que un porcentaje tan alto desee trabajar fuera del país. (Rev Cuid 2010;1(1:53-62.Palabras clave: satisfacción en el trabajo, personal de enfermería, motivación, condiciones de trabajo

  13. Agriculture for Space: People and Places Paving the Way

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    Wheeler Raymond M.


    Full Text Available Agricultural systems for space have been discussed since the works of Tsiolkovsky in the early 20th century. Central to the concept is the use of photosynthetic organisms and light to generate oxygen and food. Research in the area started in 1950s and 60s through the works of Jack Myers and others, who studied algae for O2 production and CO2 removal for the US Air Force and the National Aeronautics and Space Administration (NASA. Studies on algal production and controlled environment agriculture were also carried out by Russian researchers in Krasnoyarsk, Siberia beginning in 1960s including tests with human crews whose air, water, and much of their food were provided by wheat and other crops. NASA initiated its Controlled Ecological Life Support Systems (CELSS Program ca. 1980 with testing focused on controlled environment production of wheat, soybean, potato, lettuce, and sweetpotato. Findings from these studies were then used to conduct tests in a 20 m2, atmospherically closed chamber located at Kennedy Space Center. Related tests with humans and crops were conducted at NASA’s Johnson Space Center in the 1990s. About this same time, Japanese researchers developed a Controlled Ecological Experiment Facility (CEEF in Aomori Prefecture to conduct closed system studies with plants, humans, animals, and waste recycling systems. CEEF had 150 m2 of plant growth area, which provided a near-complete diet along with air and water regeneration for two humans and two goats. The European Space Agency MELiSSA Project began in the late 1980s and pursued ecological approaches for providing gas, water and materials recycling for space life support, and later expanded to include plant testing. A Canadian research team at the University of Guelph developed a research facility ca. 1994 for space crop research. The Canadian team eventually developed sophisticated canopy-scale hypobaric plant production chambers ca. 2000 for testing crops for space, and have


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    Musa KAYA


    Full Text Available Language, whose importance in building up the national identity and culture as well as in maintaining them cannot be ignored, is an essential and irreplaceable instrument to transmit all material possessions and moral values to the next generations. Therefore, teaching Turkish language, which is the transmitter of Turkish culture, not only to the learners in Turkey but also to the Turkish children living abroad and to the foreign people who want to learn Turkish is of great importance. As a result of the study, it was found that Turkish language instruction was available as an elective language course in 44 universities and colleges in total in the whole USA, where approximately 500.000 Turks live currently. However, it was also revealed that Turkish language instruction was unavailable in schools providing primary and secondary education, and all of the activities concerning the instruction of Turkish language and culture were conducted by the lecturers and teachers living in the USA, where there were no teachers and lecturers appointed from Turkey yet. Milli kimlik ve kültürün teşekkülünde olduğu gibi onun yaşatılmasında da önemi göz ardı edilemeyecek olan dil, sahip olunan maddi ve manevi bütün değerlerin sonraki nesillere aktarılması bakımından vazgeçilemez ve yeri doldurulamaz bir araçtır. Bu sebeple Türk kültürünün taşıyıcısı olan Türkçenin sadece yurt içinde değil aynı zamanda yurt dışındaki Türk çocuklarına ve Türkçeyi öğrenmek isteyen yabancılara öğretimi büyük önem taşımaktadır. Yapılan araştırmada, yaklaşık 500 bin Türk’ün yaşadığı ABD’de toplam 44 üniversite ve kolejde Türkçenin seçmeli yabancı dil olarak öğretiminin yapıldığı, temel eğitim ve lise seviyesindeki okullarda Türkçe öğretiminin yapılamadığı; Türkçe ve Türk kültürü öğretimi ile ilgili faaliyetlerin ABD’de bulunan öğretim görevlileri ve öğretmenler tarafından ger

  15. Greenhouse Module for Space System: A Lunar Greenhouse Design

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    Zeidler Conrad


    Full Text Available In the next 10 to 20 years humankind will return to the Moon and/or travel to Mars. It is likely that astronauts will eventually build permanent settlements there, as a base for long-term crew tended research tasks. It is obvious that the crew of such settlements will need food to survive. With current mission architectures the provision of food for longduration missions away from Earth requires a significant number of resupply flights. Furthermore, it would be infeasible to provide the crew with continuous access to fresh produce, specifically crops with high water content such as tomatoes and peppers, on account of their limited shelf life. A greenhouse as an integrated part of a planetary surface base would be one solution to solve this challenge for long-duration missions. Astronauts could grow their own fresh fruit and vegetables in-situ to be more independent from supply from Earth. This paper presents the results of the design project for such a greenhouse, which was carried out by DLR and its partners within the framework of the Micro-Ecological Life Support System Alternative (MELiSSA program. The consortium performed an extensive system analysis followed by a definition of system and subsystem requirements for greenhouse modules. Over 270 requirements were defined in this process. Afterwards the consortium performed an in-depth analysis of illumination strategies, potential growth accommodations and shapes for the external structure. Five different options for the outer shape were investigated, each of them with a set of possible internal configurations. Using the Analytical Hierarchy Process, the different concept options were evaluated and ranked against each other. The design option with the highest ranking was an inflatable outer structure with a rigid inner core, in which the subsystems are mounted. The inflatable shell is wrapped around the core during launch and transit to the lunar surface. The paper provides an overview of the

  16. Hydroponic cultivation of soybean for Bioregenerative Life Support Systems (BLSSs) (United States)

    De Pascale, Stefania; De Micco, Veronica; Aronne, Giovanna; Paradiso, Roberta

    For long time our research group has been involved in experiments aiming to evaluate the possibility to cultivate plants in Space to regenerate resources and produce food. Apart from investigating the response of specific growth processes (at morpho-functional levels) to space factors (namely microgravity and ionising radiation), wide attention has been dedicated to agro-technologies applied to ecologically closed systems. Based on technical and human dietary requirements, soybean [Glycine max (L.) Merr.] is studied as one of the candidate species for hydroponic (soilless) cultivation in the research program MELiSSA (Micro-Ecological Life Support System Alternative) of the European Space Agency (ESA). Soybean seeds show high nutritional value, due to the relevant content of protein, lipids, dietary fiber and biologically active substances such as isoflavones. They can produce fresh sprouts or be transformed in several edible products (soymilk and okara or soy pulp). Soybean is traditionally grown in open field where specific interactions with soil microrganisms occur. Most available information on plant growth, seed productivity and nutrient composition relate to cultivated varieties (cultivars) selected for soil cultivation. However, in a space outpost, plant cultivation would rely on soilless systems. Given that plant growth, seed yield and quality strictly depend on the environmental conditions, to make successful the cultivation of soybean in space, it was necessary to screen all agronomic information according to space constraints. Indeed, selected cultivars have to comply with the space growth environment while providing a suitable nutritional quality to fulfill the astronauts needs. We proposed an objective criterion for the preliminary theoretical selection of the most suitable cultivars for seed production, which were subsequently evaluated in bench tests in hydroponics. Several Space-oriented experiments were carried out in a closed growth chamber to

  17. Can nitrification bring us to Mars? The role of microbial interactions on nitrogen recovery in life support systems (United States)

    Christiaens, Marlies E. R.; Lasseur, Christophe; Clauwaert, Peter; Boon, Nico; Ilgrande, Chiara; Vlaeminck, Siegfried


    Human habitation in space requires artificial environment recirculating fundamental elements to enable the highest degree of autonomy . The European Space Agency, supported by a large consortoium of European organisationsdevelop the Micro-Ecological Life Support System (MELiSSA) to transform the mission wastes waste (a.o. organic fibers, CO2, and urine) into water, oxygen, and food (Lasseur et al., 2010). Among these wastes, astronauts' urine has a high potential to provide nitrogen as a fertilizer for food production. As higher plant growth in space is typically proposed to be performed in hydroponics, liquid fertilizer containing nitrates is preferred. An Additional Unit for Water Treatment is developed for urine nitrification by means of a synthetic microbial community. The key players in this consortium are ureolytic bacteria to hydrolyse the main nitrogen source in urine, urea, to ammonium and carbon dioxide as well as oxidation of organic compounds present in urine, ammonium oxidizing bacteria (AOB) to convert ammonium to nitrite (nitritation), and the nitrate oxidizing bacteria (NOB) to produce nitrate (nitratation). Pure AOB strains Nitrosomonas ureae Nm10 and Nitrosomonas europaea ATCC 19718, pure NOB strains Nitrobacter winogradskyi Nb-255 and Nitrobacter vulgaris Z, and interactions within synthetic consortia of one AOB and one NOB or all together were tested. As the initial salinity of fresh urine can be as high as 30 mS/cm, the functionality of selected pure strains and synthetic consortia was evaluated by means of the nitritation and nitratation activity at varying NaCl salinities (5, 10, and 30 mS/cm). The nitritation activity of pure AOB strains was compared with the synthetic consortia. Both N. ureae and Ns. europaea benefit from the presence of Nb. winogradskyi as the ammonium oxidation rates of 1.7 ± 0.7 and 6.4 ± 0.6 mg N/L.d at 5 mS/cm, respectively, doubled. These results are in line with the findings of Perez et al (2015) observing a lower

  18. The comparison between two airborne LiDAR datasets to analyse debris flow initiation in north-western Iceland (United States)

    Morino, Costanza; Conway, Susan J.; Balme, Matthew R.; Jordan, Colm; Hillier, John; Sæmundsson, Þorsteinn; Argles, Tom


    different airborne LiDAR datasets has proven to be a powerful tool, not just in the topographic analysis of landscape, but also in the discrimination of the causes of potentially disastrous phenomena. This suggests new possibilities for using remote sensing analysis to mitigate the effects of natural hazards. References: [1] Rickenmann, D., 1999. Natural Hazards, 19 (1), 47-77. [2] Iverson, R.M., 1997. Reviews of Geophysics, 35 (3), 245-296. [3] Clague, J.J., Evans, S.G., Blown, I.G., 1985. Journal of Earth Sciences, 22 (10), 1492-1502. [4] Kanji, M.A., Cruz, P.T., Massad, F., 2008. Landslides, 5 (1), 71-82. [5] Johnson, A.M. and Rodine, J. R. 1984. Slope Instability. Wiley, New York, 257-361. [6] Coe, J.A., Glancy, P.A., Whitney, J.W., 1997. Geomorphology, 20, 11-28. [7] Griffiths, P.G., Webb, R.H., Melis, T.S., 2004. Journal of Geophysical Research, 109, 321-336. [8] Conway, S. J., Decaulne, A., Balme, M. R., Murray, J. B., Towner, M. C., 2010. Geomorphology, 114 (4), 556-572. [9] Decaulne, A., Sæmundsson, Þ., Pétursson, O., 2005. Geografiska Annaler: Series A, Physical Geography, 87A, 487-500.

  19. Gyroscope like molecules consisting of trigonal or square planar osmium rotators within three-spoked dibridgehead diphosphine stators: syntheses, substitution reactions, structures, and dynamic properties. (United States)

    Fiedler, Tobias; Bhuvanesh, Nattamai; Hampel, Frank; Reibenspies, Joseph H; Gladysz, John A


    Reactions of (NH4)2OsX6 (X = Cl, Br) with CO and the phosphines P((CH2)mCH[double bond, length as m-dash]CH2)3 (m = 6, a; 7, b; 8, c) give cis,cis,trans-Os(CO)2(X)2(P((CH2)mCH[double bond, length as m-dash]CH2)3)2 (46-73%). These are treated with Grubbs' catalyst (7 mol%, 0.0010 M, C6H5Cl). Subsequent hydrogenations (PtO2) yield the gyroscope like complexes cis,cis,trans-Os(CO)2(X)2(P((CH2)n)3P) (n = 2m + 2; X = Cl, 6a-c; Br, 7a-c ; 5-31%) and the isomers cis,cis,trans-Os(CO)2(X)2(P(CH2)n-1CH2)((CH2)n)(P(CH2)n-1CH2) (X = Cl, 6'ac; Br, 7'a-c;12-51%) derived from a combination of interligand and intraligand metatheses. Reductions of 6a,c, 6’b, and 7'b with C8K under CO atmospheres afford trans-Os(CO)3(P((CH2)n)3P) (9a,c, 79-82%) and trans-Os(CO)3(P(CH2)15CH2)((CH2)16)(P(CH2)15CH2) (9’b, 53-84%). Reaction of 9a and CF3SO3H yields the cationic hydride complex mer,trans-[Os(H)(CO)3(P((CH2)14)3P)](+) CF3SO3(-) (9a-H(+) CF3SO3(-); quantitative by NMR). Preparative reactions of 9a,c or 9'b and [H(OEt2)2](+) BArf(-) (BArf(-) = B(3,5-C6H3(CF3)2)4(-)) afford 9a,c-H(+) BArf(-) (80%) or 9'b-H(+) BArf(-) (68%). Reactions of 6a, 6’b, and 7a with MeLi or PhLi give cis,cis,trans-Os(CO)2(Me)2(P((CH2)14)3P) (11a, 98%), cis,cis,trans-Os(CO)2(Me)2(P(CH2)15CH2)((CH2)16)(P(CH2)15CH2) (98%), and cis,cis,trans-Os(CO)2(Ph)2(P((CH2)14)3P) (12a, 58%). NMR data for 6a–c, 7a–c, 9a,c, 9a,c-H(+) X(-), and 11a indicate that rotation of the OsLy moieties is fast on the NMR time scale at room temperature. In contrast, the phenyl groups in 12a act as "brakes" and two sets of (13)C NMR signals are observed for the methylene chains (2 : 1). The crystal structures of 6a–c, 7b,c, 7’a, 9a, 9a -H(+) BArf(-), 11a, and 12a are analyzed with respect to OsLy rotation in solution and the solid state.

  20. 5th National Congress of the Italian Society of Physiotherapy

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    Alessandro Aina


    , Aina Alessandro P3 Hamstring injuries: clinical assessment or image evaluation? Bonfanti M., Pasquetti M. P4 Effectiveness of the physical therapy treatment on pelvic floor muscles in pelvic girdle pain. A literature review Bortolami Arianna, Pillastrini Paolo, Vanti Carla P5 Scapulo-humeral muscles electromiographic activity during the elevation movement of the upper limb in subjects with rotator cuff lesion Brioschi D, Vitali M, Pedretti A, Fraschini G, Tettamanti A P6 Mechanical low back pain: secular trend and intervention topics of randomized controlled trials Castellini G, Gianola S, Bonovas S, Banfi G, Moja L P7 Quality of reporting in rehabilitation interventions for low back pain: a review of published randomised controlled trials Greta Castellini, Silvia Gianola, Pamela Frigerio, Michela Agostini, Rosa Bolotta, Davide Corbetta, Monica Gasparini, Paolo Gozzer, Erica Guariento, Linda Li, Valentina Pecoraro, Valeria Sirtori, Andrea Turolla, Andreano A, Lorenzo Moja P8 Power analysis and sample size reporting in rehabilitation of low back pain: review of randomized controlled trials included in Cochrane systematic review Castellini G, Gianola S, Bonovas S, Moja L P9 A core outcome set for clinical trials in non-specific low back pain Alessandro Chiarotto, Caroline B. Terwee, Maarten Boers, Raymond W. Ostelo P10 Roland & Morris Disability Questionnaire and Oswestry Disability Index: which has better measurement properties? A systematic review and meta-analysis Alessandro Chiarotto, Lara J. Maxwell, Caroline B. Terwee, George A. Wells, Peter Tugwell, Raymond W. Ostelo P11 Prevalence of myofascial trigger points in spinal pain disorders: systematic review and meta-analysis Alessandro Chiarotto, Ron Clijsen, Cesar Fernandez-de-las-Penas, Marco Barbero P12 Post-surgical scar rating scales in physiotherapy: a systematic review Ciceri Matteo, Rossetti Sara, Vercelli Stefano P13 Efficacy of action observation pre-operative training in functional recovery after hip and

  1. EDITORIAL: Announcing the 2007 Measurement Science and Technology Outstanding Paper Awards (United States)

    Foss, John; Dewhurst, Richard; Fujii, Kenichi; Regtien, Paul


    Nanoscale Systems Integration Group, School of Electronics and Computer Science, University of Southampton, Southampton SO17 1BJ, UK The paper [2] describes a novel impedance spectroscopic measurement method for applications in the identification of biological cells. The frequency-dependent impedance is obtained in the frequency domain by applying a fast M-sequence transform (FMT), and a fast Fourier transform (FFT) in the time domain response. Using FMT, the evaluation takes place within a short timescale of the order of milliseconds. This technique is used in a microfluidic impedance cytometer, for the analysis of single biological cells in suspension. The theory of the technique is analysed in depth. It is then applied to an experimental system that characterizes the impedance spectrum of red blood cells within the microfluidic system. Measured spectra show good agreement with simulations. The paper has a short but excellent introduction, supported by a solid reference list of about 55 papers describing related work. Most of these papers are citations from 2000 onwards. This is followed by a detailed analysis of maximum length sequences and theory used for predictions of spectra. It then continues with a useful description of a cytometer that was used to confirm theoretical predictions of spectra. Results are at an early stage. The system is still under development, since there are issues arising from the fact that the particle flows during the acquisition of data, and is not static in the electric field as assumed by the model. Nevertheless, the paper possesses good clarity of the motivation behind the work, of the measurement techniques developed and of the potential relevance to applications in the life sciences. 2007 Award Winners—Precision Measurement Ultraprecision micro-CMM using a low force 3D touch probe A Küng, F Meli and R Thalmann Swiss Federal Office of Metrology (METAS), Lindenweg 50, CH-3003 Bern-Wabern, Switzerland The paper [3] describes a new three

  2. Almanca Öğretmen Adaylarının Almanca Konuşma Becerilerine İlişkin Yeterlik Düzeylerinin İncelenmesi Examining The Level Of Proficiency In German Speaking Skills Of Preservice German Teachers

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    Bahar İŞİGÜZEL


    zeyi Belirleme Anketi” kullanılmıştır. Diller İçin Avrupa Ortak Başvuru Metninde (OBM konuşma becerisi için belirlenmiş olan dil betimleyicileri ışığında hazırlanmış olan anket 65 maddeden ve 3 düzeyden (A temel, B bağımsız, C yetkin oluşmaktadır. Anketin Cronbach Alpha güvenirlik katsayıları A düzeyi için 0.96, B düzeyi için 0.94, C düzeyi için 0.93 ve anketin tüm düzeyler için 0.88 olarak hesaplanmıştır. Almanca öğretmen adaylarının ulaştıkları konuşma becerisi yeterlik düzeyleri A (temel düzey için ileri düzey, B (bağımsız ve C (yetkin düzeyleri için orta düzey olarak belirlenmiştir. Ayrıca Almanca konuşma becerisi düzeyleri ile cinsiyet, yaş, akademik ortalama, üniversite sınavında alınan test dili ve mezun oldukları lise türü gibi bağımsız değişkenler arasında sadece üniversite sınavında yapılan test dili ile anlamlı bir fark bulunmuştur. Cinsiyet, yaş, akademik ortalama ve mezun olduğu lise türü ile Almanca konuşma becerisi düzeyleri arasında anlamlı bir fark bulunmamıştır. Bu araştırmanın sonuçları açısından Almanca öğretmen adaylarının kendilerini genel konuşma becerisi yeterlilik düzeyleri açısından A (temel için ileri, B (bağımsız ve C (yetkin düzeylerinde orta düzey yeterlikte görmüş olsalar da, konuşma becerilerini geliştirebilmek için programlarında yer alan konuşma becerisi derslerine ek olarak Almanca öğretimi konusunda alanlarıyla ilişkili konuşma becerilerini geliştirici seçmeli dersler eklenmesinde fayda vardır.

  3. Reconstructing the post-LGM decay of the Eurasian Ice Sheets with Ice Sheet Models; data-model comparison and focus on the Storfjorden (Svalbard) ice stream dynamics history (United States)

    Petrini, Michele; Kirchner, Nina; Colleoni, Florence; Camerlenghi, Angelo; Rebesco, Michele; Lucchi, Renata G.; Forte, Emanuele; Colucci, Renato R.


    climate simulation. In this presentation, we will show work in progress, address open issues, and sketch future work. In particular, we invite the community to suggest possibilities for model-data comparison and integration. Liu, Z., Otto-Bliesner, B.L., He, F., Brady, E.C., Tomas, R., Clark, P.U., Carlson, A.E., Lynch-Stieglitz, J., Curry, W., Brook, E. and Erickson, D., 2009. Transient simulation of last deglaciation with a new mechanism for Bólling-Alleród warming. Science, 325(5938), pp.310-314. Lucchi, R.G., Camerlenghi, A., Rebesco, M., Colmenero-Hidalgo, E., Sierro, F.J., Sagnotti, L., Urgeles, R., Melis, R., Morigi, C., Bárcena, M.A. and Giorgetti, G., 2013. Postglacial sedimentary processes on the Storfjorden and Kveithola trough mouth fans: Significance of extreme glacimarine sedimentation. Global and planetary change, 111, pp.309-326. Martin, M.A., Winkelmann, R., Haseloff, M., Albrecht, T., Bueler, E., Khroulev, C. and Levermann, A., 2011. The Potsdam Parallel Ice Sheet Model (PISM-PIK)-Part 2: Dynamic equilibrium simulation of the Antarctic ice sheet. The Cryosphere, 5(3), pp.727-740. Pedrosa, M.T., Camerlenghi, A., De Mol, B., Urgeles, R., Rebesco, M. and Lucchi, R.G., 2011. Seabed morphology and shallow sedimentary structure of the Storfjorden and Kveithola trough-mouth fans (north west Barents Sea). Marine Geology, 286(1), pp.65-81. Pollard, D. and DeConto, R.M., 2012. Description of a hybrid ice sheet-shelf model, and application to Antarctica. Geoscientific Model Development, 5(5), pp.1273-1295. Rebesco, M., Liu, Y., Camerlenghi, A., Winsborrow, M., Laberg, J.S., Caburlotto, A., Diviacco, P., Accettella, D., Sauli, C., Wardell, N. and Tomini, I., 2011. Deglaciation of the western margin of the Barents Sea Ice Sheet-a swath bathymetric and sub-bottom seismic study from the Kveithola Trough. Marine Geology, 279(1), pp.141-147. Rebesco, M., Laberg, J., Pedrosa, M., Camerlenghi, A., Lucchi, R., Zgur, F. and Wardell, N., 2013. Onset and growth of Trough


    Directory of Open Access Journals (Sweden)

    Ali GÖÇER


    tarama tekniği kullanılmıştır. İncelenecek Türkçe öğrenci çalışma kitaplarının toplanacağı ilköğretim okulları, amaçlı ve tabakalamalı örnekleme yolu ile belirlenmiştir. Bu çerçevede 2008-2009 öğretim yılı sonunda Kayseri’de Melikgazi, Kocasinan ve Tomarza ilçelerinin her birinden 3 olmak üzere toplam 9 ilköğretim okulu belirlenmiştir. Okulların 6. ve 7. sınıflarında öğrenim gören öğrenciler arasından seçkisiz olarak 3’er öğrenci belirlenerek 6. ve 7. sınıf düzeyinde 27’şer olmak üzere toplam 54 Türkçe Öğrenci Çalışma Kitabı (ÖÇK toplanmıştır. Her sınıf düzeyinde bir seçmeli bir de zorunlu olmak üzere 4 tema seçilmiştir. Öğrenci çalışma kitaplarının belirlenen temalarında yer alan etkinliklerin gerçekleştirilme düzeyini belirlemek amacıyla her bir etkinlik incelenerek durum tespiti yapılmıştır. Elde edilen verilere göre, incelenen kitaplarındaki gerçekleştirilen etkinliklerin gerçekleştirilmeyenlerden oransal olarak fazla olsa da öğrenci çalışma kitaplarının işlevsel olarak kullanılmadığı kanaatine varılmıştır.


    Directory of Open Access Journals (Sweden)

    Murat TUNCER


    ılarak tek faktörlü yapısında karar kılınmış, ölçeğin cronbach alfa katsayısı .84 bulunmuştur. Hazırlanan ölçek Tunceli Meslek Yüksekokulunun farklı bölümlerinde öğrenim gören 430 öğrenciye uygulanmıştır. Ölçek uygulamasıyla elde edilen verilerin analizinde Bağımsız gruplar t testi, Anova testi, Mann Whitney U testi, Kruskal Wallis H ve Tukey HSD testinden yararlanılmıştır. Analiz sonuçlarına göre Meslek yüksek okulu öğrencilerinin gelecek beklentileri arasında cinsiyet değişkeni göre kız öğrenciler lehine anlamlı fark bulunmuştur. Ayrıca öğrencilerin gelecek beklentileri arasında 3-4 kardeşe sahip öğrenciler ile 5 ve daha fazla kardeş sayısına sahip öğrenciler arasında da anlamlı fark bulunmuştur. Öğrencilerin gelecek beklentileri anlamında küreselleşme ve teknolojiye bağlı olarak yaşadıklarına inanılan belirsizliklerin giderilmesinde sektörle olan ilişkinin güçlendirilmesinin yarar getireceği düşünülmektedir. Bunun yanında seçmeli dersler ya da esnek eğitim modelleriyle eğitim alınan mesleki programın dışında meslek dallarında eğitim verilerek geleceğe daha hazır kılınmaları önerilmektedir.

  6. Selected Abstracts of the 11th International Workshop on Neonatology; Cagliari (Italy; October 26-31, 2015

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    --- Various Authors


    . Newborn with multiple bone fractures • A.L. Costa, A.R. Moreira, P. Soares, A.Vilan, N. Alegrete, C. Martins, S. Gama Sousa, M. Rodrigues, H. Guimarães • Porto and Vila Nova de Famalicão (Portugal ABS 9. Birthweight and maternal lifestyle in overweight/obese women: a case-control study • R. Bruno, G. Pedrielli, P. Elisabetta, V. Bertarini, I. Neri, F. Facchinetti • Modena (Italy ABS 10. Special fixation for transmission electron microscopy unmasks unexpected structural details within the renal stem/progenitor cell niche • L. Denk, W.W. Minuth • Regensburg (Germany ABS 11. Drug use among newborns admitted to NICUs: a multicentre study • L. Cuzzolin, R. Agostino • Rome and Verona (Italy ABS 12. Assessment of renal function in neonatology • J.R. Delanghe • Gent (Belgium ABS 13. The parental competence in neonatology • C.M. Cacciatore, M.R. Morales, G. Perricone, C. Polizzi, G. Sulliotti, A. Rizzo, D. Albino • Palermo (Italy ABS 14. Epidemiological, clinical, and microbiological aspects in newborns with neonatal infection (sepsis and unspecified neonatal infection treated at the Department of Neonatology of the Lithuanian University of Health Sciences during 2007-2013 • R. Dzikienė, R. Tamelienė, D. Stonienė, R. Vidmantė, J. Garčinskienė • Kaunas (Lithuania ABS 15. Metabolomics in obstetrics: future perspectives • R. Mereu, A. Meloni, L. Barberini, S.F. Deiana, A. Noto, G.B. Melis • Cagliari (Italy ABS 16. Single-blind randomized controlled clinical trial to evaluate the nutritional adequacy of a novel human milk fortifier derived from donkey milk for the nutrition of newborns with birthweight < 1,500 g or gestational age < 32 weeks • C. Rossi, C. Peila, M. Raia, S. De Antoni, A. Noto, F. Cesare Marincola, S. Corbu, V. Fanos, E. Bertino, A. Coscia • Cagliari and Turin (Italy ABS 17. The stem cell niche in the developing cerebral cortex • L. Vinci, A.G. Naccarato, S. Nati, G. Senes, R. Murru, C. Gerosa, E. Obinu, V. Pibiri, M


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    Emine ATMACA


    Full Text Available Kazak Türkçesi ağızlarının fonetik, gramatik ve leksikolojik açıdan ilmî olarak incelenmesine SSCB Dönemi’nde başlanmıştır. Sovyet Bilimler Akademisinin Kazak Bölümü, 1937 yılında Almatı eyaletinin Kegen, Narınkol’a, Güney Kazakistan eyaletinin Maktaaral ilçesine ve Karagandı eyaletinin Nura ilçesine üç ayrı uzman ekip göndererek ağız incelemelerini başlatmıştır. Bu çalışmalar, 1939 yılında Mangıstav, Torgay’da, 1940 yılında Sarısu, Aral, Orda’da devam etmiş ve bu bölgelerden pek çok ağız malzemesi derlenmiştir. Derlenen bu ağız malzemeleri, 1953 yılından sonra S. Amanjolov, J. Doskarayev, N. T. Savranbayev ve G. Musabayev gibi Kazak diyalekti uzmanlarının Kazak diyalektini sınıflandırma çalışmalarına kaynaklık etmiştir. Bu makalede, Kazak ağızlarını S. Amanjolov, a güney diyalekti b batı diyalekti ve c kuzeydoğu diyalekti olarak üçe; J. Doskarayev, Kazak Türkçesinde iki büyük ağız grubunun varlığına işaret ederek a güneydoğu ağız grubu b kuzeybatı ağız grubu olarak ikiye; N. T. Savranbayev fonetik özelliklerine göre a Kazakistan’ın kuzeyindeki ve batı eyaletlerindeki /ş/, /d/ diyalektler grubu b Kazakistan’ın güney ve güneydoğu eyaletlerindeki /ç/, /l/ diyalektler grubu olmak üzere ikiye; G. Musabayev, a değişmeli ağız b mahallî ağız olmak üzere iki gruba ayırma nedenleri ve sınıflandırmada kullandıkları yöntemler üzerinde durulmuştur. Scientific study of grammar, phonetics and lexicography dialects of the Kazakh language began in the Soviet period. Kazakh SSR Academy of Sciences has begun conducting research on dialects, sending in 1937, three separate groups of specialists in the villages and Kegen, Narınkol Almaty region, Maktaaral district of South Kazakhstan region and Nura District Karagandi area. This work, continued in 1939 in Mangistav and Torgay regions in 1940 in areas Sarısu, Aral and the Horde. In

  8. Ortaöğretim Müzik Dersine Yönelik Başarı Testinin Geliştirilmesi Developing The Achievement Test For The Secondary Education Music Course

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    Yakup Alper VARIŞ


    ında müzik derslerinin planlanması, programlanması, yapılandırılması, çeşitli açılarından düzenlenip geliştirilmesi ve bütünsel bir bakış açısıyla değerlendirilmesi bakımından öğrencilerin elde etmeleri beklenen kuramsal bilgilere ne derece ulaştıkları belirlenmelidir. Müzik kuramları eğitiminin ortaöğretim aşamasında kapsamca genişlemesi ve ilerlemesi göz önüne alındığında müzik derslerinde öğrencilerin bilişsel becerilerinin ölçülmesinin önemi belirgin bir biçimde ortaya çıkar. Bu nedenle, müzik derslerine yönelik akademik başarı testlerinin geliştirilmesinin gerekliliği ön plana çıkmaktadır. Bu araştırmanın amacı ortaöğretim düzeyinde müzik dersi alan öğrencilerin kazanmaları hedeflenen temel müzik bilgilerini ölçmeye yarayan, geçerlik ve güvenilirlik çalışması yapılmış bir başarı testi geliştirmektir. Kapsam geçerliği için uzman görüşlerine başvurulan ölçme aracının güvenirliği için başarı testi içerisindeki maddelerin çoktan seçmeli olması ve 1-0 madde yapısı göstermesi nedeniyle KR-20 iç tutarlılık katsayısı kullanılmış madde güçlük indeksi ile madde ayırt edicilik indeksleri hesaplanmıştır. Bu analizler için ITEMAN analiz programından yararlanılmıştır. Buna göre, ortalama madde güçlük ve ayırt edicilik indeksleri sırasıyla 0,411 ve 0,384 olarak belirlenmiştir. Uzman görüşleri ve madde analizi sonunda 25 maddeye indirgenen başarı testinin geçerliliğinin yüksek olduğu saptanmıştır. Güvenirlik çalışmaları 180 öğrenci üzerinde yapılmıştır. Analiz sonucunda ölçme aracının KR-20 güvenilirlik katsayısı 0,76 bulunmuştur. Sonuç olarak Ortaöğretim Müzik Dersi Başarı Testi’nin, ortaöğretim öğrencilerinin müzik dersindeki akademik başarılarını ölçmede kullanılabilecek yeterli düzeyde geçerlik ve güvenirlik değerlerine sahip bir ölçek olduğu saptanmıştır.

  9. Determining the Teacher Candidates’ Perceptions on Distance Education by Metaphors [Öğretmen Adaylarının Uzaktan Eğitime Yönelik Algılarının Metaforlar Yoluyla Belirlenmesi

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    Gül Kaleli Yılmaz


    olan 150 öğretmen adayı oluşturmaktadır. Bu öğretmen adaylarından 70’i lisans eğitimleri sırasında uzaktan eğitim yoluyla ders almış olan sınıf öğretmeni adaylarıdır. 80’i ise seçmeli ders olarak uzaktan eğitim isimli teorik dersi almış olan fen bilgisi öğretmeni adaylarıdır. Verilerin toplanması için araştırmaya katılan öğretmen adaylarından “Uzaktan eğitim… gibidir çünkü …” cümlesini tamamlamaları istenmiştir. Araştırmada veriler nitel veri analizi yöntemleri içerisinde yer alan içerik analizi tekniği kullanılarak analiz edilmiştir. Yapılan analizler sonucunda, öğretmen adaylarının uzaktan eğitime yönelik oluşturdukları metaforların ihtiyaca yönelik, çeşitlilik, isteğe bağlılık, gereklilik gibi farklı kategoriler altında toplandığı görülmüştür. Ayrıca bulgular incelendiğinde eş-zamanlı uzaktan eğitim yoluyla ders alan sınıf öğretmeni adaylarının, fen bilgisi öğretmeni adaylarına kıyasla daha olumsuz algılara sahip oldukları tespit edilmiştir. Eş-zamanlı uzaktan eğitim derslerinin 90 dakikalık blok dersler halinde yürütülmesi, öğretmen adaylarının ders dışında öğretmene soru sorma imkânı bulamayışı, derslerde zaman zaman teknik problemlerin yaşanması gibi faktörlerin olumsuz algıya neden olduğu fark edilmiştir. Uzaktan eğitime yönelik olumlu algı geliştirilebilmesi için; kısa süreli, uygulama öncesinde katılımcıların uzaktan eğitim uygulamaları hakkında bilgilendirildiği, öğretmen ve öğrencinin ders dışında da iletişim kurabildiği ve teknik problemlerin en aza indirildiği uzaktan eğitim ortamlarının tasarlanması önerilmektedir.

  10. AAS 228: Day 1 morning (United States)

    Kohler, Susanna


    Kohler)The first press conference of the meeting featured four speakers discussing some of the latest developments in the field of exoplanet and brown dwarfs.Artists impression of the surface of a massive, planet-like body being devoured by a white dwarf. [A. Hara/C. Melis/W. M. Keck Observatory]First up was Carl Melis (UC San Diego), who discussed the discovery of a rocky exoplanetary body currently being shredded by a white dwarf. As the white dwarfs strong gravitational pull tears the body apart, we can observe the material pulled from its surface layers. These observations made by Keck Observatory and Hubble indicate that the body might have been Earth-like, with an outer surface of made up of limestone. Heres the press release.Next, Avi Shporer (NASA Jet Propulsion Laboratory) spoke about the first transiting brown dwarf found in K2 mission data. Stars like companionship, but the companions are usually other massive stars, or Jupiter-size or smaller planets. Companions with the mass and size of brown dwarfs are uncommon, leading to the term brown dwarf desert. The brown dwarf found by K2 marks the 12th transiting brown dwarf we have discovered.Jerome Orosz (San Diego State University) was up next, presenting the largest and longest-period circumbinary planet yet discovered. This planet is in an orbit with a 3-year period around a two-star binary system (think Tatooine!). This is the longest orbital period of any confirmed transiting exoplanet, and this Jupiter-sized planet, which is in the circumbinarys habitable zone, is the largest circumbinary planet weve observed. Heres the press release.Jerome Orosz on the largest and longest-period circumbinary planet found in Kepler data #aas228 #tatooine astrobites (@astrobites) June 13, 2016Finally, Sean Mills (University of Chicago) spoke about Kepler-108, a giant planet system in which the two exoplanets dont orbit within the same plane. This is detectable because the transits of these planets

  11. Control of the geomorphic evolution of an active crater: Popocatpetl (Mexico) 1994-2003. (United States)

    Andrés, N.; Zamorano, J. J.; Palacios, D.; Macias, J. L.; Sanjosé, J. J.


    . References.- Cruz-Reyna, S. de la; Meli, R.; Macías, J.L.; Castillo, F.; & Cabrera, B., 1998. Cyclical dome extrusions that by late 1997 filled one-third of crater capacity, In Smithsonian-GVP Monthly Reports, Popocatépetl, Smithsonian Institution. Bull. Glob. Volcanism Netw, (GVN) 23 (2), 2 - 4. Donnadieu, F.; Kelfoun, K.; Van Wyk de Vries, B.; Decchi, E.; & Merle, O., 2003. Digital photogrammetry as a tool in analogue modelling: applications to volcano instability, Journal of Volcanology and Geothermal Research, 123 (1-2), 161-180. Macías, J.L. & Siebe, C., 2005. Popocatépetl crater filled to the brim: significance for hazard evaluation, Journal of Volcanology and Geothermal Research (141) 327-330. Martín-Del Pozzo, A.L.; Cifuentes-Nava, G.; Cabral-Cano, E.; Bonifaz, F.; Correa, I.; & Mendiola, I.F., 2003. Timing magma ascent at Popocatepetl Volcano, Mexico, 2000-2001, Journal of Volcanology and Geothermal Research ,125, 107-120. Matiella, M.A.; Watson, I.M.; Delgado, H.; Rose, W.I.; , Cárdenas, L.; & Realmuro, V.J., 2008, Volcanic emissions from Popocatépetl volcano, Mexico, quantified using Moderate Resolution Imaging Spectroradiometer (MODIS) infrared data: A case study of the December 2000-January 2001 emissions, Journal of Volcanology and Geothermal Research, 170, 1-2, 76-85. Procter, J.N.; Platz, T.; & Cronin, S.J., 2006. A remnant summit lava dome and its influence on future eruptive hazards, Geophysical Research Abstracts, Vol. 8, 10211. Schilling, S.P.; Ramsey, D.W.; Messerich, J.A.; & Thompson, R.A., 2006. Map: Rebuilding Mount St. Helens. U.S. Geological Survey Scientific Investigations Map 2928. Tanarro, L. M.; Zamorano, J.J.; & Palacios, D., 2005. Glacier degradation and lahar formation on the Popocatépetl volcano (Mexico) during the last eruptive period (1994-2003), Zeitschrift Geomorphologie (140) 73-92. Zamorano, J.J., Gómez, A. 1996 "Análisis geomorfoloógico a detalle,1:10 000 del cráter del volcán Popocatépetl (1989-1996)" IV Reuni

  12. PREFACE: First Mediterranean Conference on Classical and Quantum Gravity (MCCQG 2009) (United States)

    Basilakos, Spyros; Cadoni, Mariano; Cavaglia, Marco; Christodoulakis, Theodosios; Vagenas, Elias C.


    , India) Liberati, Stefano (SISSA, Trieste, Italy) Lopez-Villarejo, Juan Jose (Dep. de Física Teorica, Univ. Autonoma de Madrid, Spain) Louko, Jorma (University of Nottingham, UK) Lusanna, Luca (Sezione INFN di Firenze, Italy) Majumdar, Archan S (S N Bose National Centre for Basic Sciences, India) Melis, Maurizio (Università di Cagliari and INFN, Italy) Menotti, Pietro (Department of Physics, University of Pisa, Italy) Mignemi, Salvatore (Università di Cagliari, Italy) Monni, Cristina (Università di Cagliari and INFN, Italy) Pani, Paolo (Università di Cagliari and INFN, Italy) Papazoglou, Antonios (ICG, University of Portsmouth, UK) Páramos, Jorge (Instituto de Plasmas e Fusāo Nuclear, IST, Portugal) Pavsic, Matej (Jozef Stefan Institute, Slovenia) Perivolaropoulos, Leandros (University of Ioannina, Greece) Plionis, Manolis (Institute of Astronomy & Astrophysics, National Observatory of Athens, Greece) Pons, Josep (Universitat de Barcelona, Spain) Pouri, Athina (University of Athens, Greece) Radicella, Ninfa (Polytechnic of Turin, Italy) Rocha, Jorge (IST, Portugal) Russo, Jorge (ICREA, Universitat de Barcelona, Spain) Sakai, Norisuke (Department of Mathematics, Tokyo Woman's Christian University, Japan) Sakellariadou, Mairi (Department of Physics, King's College University of London, UK) Salisbury, Donald (Austin College, USA and MPI for the History of Science, Germany) Shnir, Yakov (National University of Ireland, Maynooth and DIAS, Ireland) Skenderis, Kostas (Institute for Theoretical Physics, University of Amsterdam, Netherlands) Sotiriou, Thomas (DAMTP, Cambridge, UK) Sundermeyer, Kurt (Free University Berlin Institute for Theoretical Physics, Germany) Tartaglia, Angelo (DIFIS, Politecnico and INFN, Torino, Italy) Vagenas, Elias (RCAAM, Academy of Athens, Greece) Wallden, Petros (Raman Research Institute, India) Wang, Bin (Fudan University, China) Weinfurtner, Silke (University of British Columbia, Canada) Zampeli, Mando (National Technical University of

  13. Selected Abstracts of the 9th International Workshop on Neonatology; Cagliari (Italy; October 23-26, 2013

    Directory of Open Access Journals (Sweden)

    --- Various Authors


    Full Text Available Selected Abstracts of the 9th International Workshop on Neonatology • LEARNED LESSONS, CHANGING PRACTICE AND CUTTING-EDGE RESEARCH • Cagliari (Italy • October 23rd-26th 2013The Workshop has been organized on behalf of Union of European Neonatal and Perinatal Societies, Union of Mediterranean Neonatal Societies, Italian Society of Neonatology, UNICEF, and under the High Patronage of the President of the Italian Republic. ABS 1. Aetiology and type of reference hospital for neonatal transport in Greece during 2012 • S. Mouskou, C. Varakis, D. Pyrros, N. Iacovidou; Athens (Greece ABS 2. Changes in neonatal outcomes of very low birth weight infants in Hospital of Lithuanian University of Health Sciences • K. Stuikiene, R. Tameliene, D. Stoniene, A. Kudreviciene, V. Ivanauskiene; Kaunas (Lithuania ABS 3. Autoimmune liver disease in childhood • Y. Gibo, D. Fanni, P. Van Eyken, S. Nemolato, G. Floris, C. Gerosa; Matsumoto (Japan, Leuven (Belgium and Cagliari (Italy ABS 4. Lactoferrin attenuates intestinal injury afther perinatal hypoxia and hypothermia • N. Barisic, G. Konstantinidis, V. Stojanovic, A. Doronjski, S. Spasojevic; Novi Sad (Serbia ABS 5. Osteopenia in prematurity: case report • K. Stuikiene, R. Tameliene, D. Stoniene, A. Kudreviciene, V. Ivanauskiene; Kaunas (Lithuania ABS 6. Neonatal Bartter syndrome: case report of a very unusual entity • A. Koutroumpa, K. Georgiou, H. Georgaki, F. Anatolitou; Athens (Greece ABS 7. Placental Growth Factor (PlGF and placental function • I. Atzeni, S.F. Deiana, A. Meloni, B. Piras, P. Zedda, S. Soddu, G. Parodo, G. Faa, G.B. Melis, A.M. Paoletti; Cagliari (Italy ABS 8. Neonatal ECMO: initial experience of Hospital de São João • G. Rocha, P. Soares, T. Henriques-Coelho, J. Correia-Pinto, J. Monteiro, H. Guimarães, R. Roncon-Albuquerque Jr; Porto (Portugal ABS 9. GCMS-based metabolomics analysis of urines in hypoxic neonatal piglets • C. Fattuoni, L. Barberini, N. Iacovidou, T

  14. PREFACE: Fourth Meeting on Constrained Dynamics and Quantum Gravity (United States)

    Cadoni, Mariano; Cavaglia, Marco; Nelson, Jeanette E.


    Cagliari, Italy) Roberto De Pietri (Università di Parma, Italy) Giuseppe De Risi (Università di Bari, Italy) Hans-Thomas Elze (Univ. Federal do Rio de Janeiro, Brasil) Alessandro Fabbri (Università di Bologna, Italy) Sergey Fadeev (VNIIMS, Moscow, Russia) Serena Fagnocchi (Università di Bologna, Italy) Sara Farese (Universidad de Valencia, Spain) Alessandra Feo (Università di Parma, Italy) Dario Francia (Università di Roma Tor Vergata, Italy) Francesco Fucito (Università di Roma Tor Vergata, Italy) Dmitri Fursaev (JINR, Dubna, Russia) Daniel Galehouse (University of Akron, Ohio, USA) Remo Garattini (Università di Bergamo, Italy) Florian Girelli (Perimeter Institute, Waterloo, Canada) Luca Griguolo (Università di Parma, Italy) Daniel Grumiller (Universität Leipzig, Germany) Shinichi Horata (Hayama Center of Advanced Research, Japan) Giorgio Immirzi (Università di Perugia, Italy) Roman Jackiw (MIT, Cambridge, USA) Matyas Karadi (DAMTP, University of Cambridge, UK) Mikhail Katanaev (Steklov Mathematical Institute, Moscow, Russia) Claus Kiefer (Universität Koln, Germany) John Klauder (University of Florida, Gainesville, USA) Pavel Klepac (Masaryk University, Brno, Czech Republic) Jen-Chi Lee (National Chiao-Tung University, Taiwan) Carlos Leiva (Universidad de Tarapacá, Arica, Chile) Stefano Liberati (SISSA/ISAS, Trieste, Italy) Jorma Louko (University of Nottingham, UK) Luca Lusanna (INFN, Sezione di Firenze, Italy) Roy Maartens (University of Portsmouth, UK) Fotini Markopoulou (Perimeter Institute, Waterloo, Canada) Annalisa Marzuoli (Università di Pavia, Italy) Evangelos Melas (QMW, University of London, UK) Maurizio Melis (Università di Cagliary, Italy) Vitaly Melnikov (VNIIMS, Moscow, Russia) Guillermo A. Mena Marugan (CSIC, Madrid, Spain) Pietro Menotti (Università di Pisa, Italy) Salvatore Mignemi (Università di Cagliari, Italy) Aleksandar Mikovic (Universidade Lusófona, Lisboa, Portugal) Leonardo Modesto (Université de la Mediterranée, Marseille

  15. AAS 228: Day 2 morning (United States)

    Kohler, Susanna


    extremely data-rich. The Galaxy Zoo project also suggests the promising prospect of synergizing the help from citizen scientists and machine learning in analyzing extremely large datasets.Extrasolar Planets: Atmospheres (by Leonardo dos Santos)Antonija Oklopi (Caltech) explains that Raman scattering of light, which works similarly to Rayleigh scattering (the process that makes Earths sky blue), can be used in the future to study the atmospheres of exoplanets. Her work is to create model spectra containing these features, from which we can learn about the presence and altitude of atmospheric clouds. Dr. Carl Melis (University of California, San Diego) studies the inner composition of exoplanets by looking at their remnants after they are destroyed by a dying star. His most recent work suggests that there is a differentiated pollution (from the core and the crust of a planet) in the disk orbiting of a white dwarf star. Samuel Grunblatt (University of Hawaii) introduces us to the main subject of his thesis: a hot-Jupiter observed by Keplers K2 mission transiting an evolved, red giant star. They used some pretty tricky data analysis in order to filter out the noise intrinsic to this type of star.Grunblatt shows the K2 transit before and after removal of granulation effects.Avi Shporer (JPL) asks the question: why are hot Jupiters so large? His research aims to study the correlation between stellar irradiation and planetary radius, and in order to have a more complete picture, they need to detect more gas giants on lower stellar irradiation regions. This idea gave rise to LCOGT K2 Warm Jupiter project, which recently discovered a brown dwarf in a long-period orbit around a Sun-like star. Paul Mason (New Mexico State University) proposes that the Milky Way is evolving to a more habitable galaxy, due to the expansion of the universe, the processing of heavier material inside stars, and the general decrease of ionizing radiation.Evolution of Galaxies (by Ben Cook)Tuesday mornings

  16. Astrobiology - The New Synthesis (United States)

    Sik, A.; Simon, T.

    to let acids and alkalis into their cells. - Halophiles: these species are identified from salt lakes, salt mines and salt crystals (some of these are 250 million years old). The salt concentration of their cytoplasm is extreme high so the outer salt can not enter. 2. Extremophiles and evolution Jelentősek az extremofilek evolúciós evolution as- pects vonatkozásai, mivel igen sok ősbaktériumot archaea találunk közöttük. A hagyományos nézet, mely szerint az élővilág a baktériumok bacteria és eukar- ióták eukaryotes birodalmára osztható, a 70-es évek végén (Woese et al), 80-as évek elején (Fox et al) ingott meg, amikor a 16S rRNS (az élővilág egyik legkonz- ervatívabb molekuláris szerkezete molecular structure) összehasonlító szekvenciav- izsgálatai comparative sequence analysis alapján kiderült: az ősbaktériumok különválasztása a legmagasabb rendszertani taxonomy level szinten is indokolt, tehát külön birodalmat separate domain képeznek. Az eddigi genomtérképezések genome sequencing során kiderült, hogy az ősbaktériumok egyes génjei csak eukar- iótákban találhatók meg, nagyobb részük pedig teljesen egyedi [14]. Újabb elméletek szerint az eubaktériumok és ősbaktériumok közös őstől származ- nak, az eukarióták pedig az ősbaktériumokból fejlődhettek ki [15]. Az ősbaktériumok az egyetemes őshöz (LUCA - "last universal common ancestor") legközelebb álló élő kövületek living fossils lehetnek. Luca: az RNS-világ RNS world, a ribo-organizmusok ribo organisms utáni első orga- nizmus, amelyben már kialakult a fehérjék proteins és a DNS DNS mai szerepe. Az ősbaktériumok tanulmányozásával tehát a közel 4 milliárd évvel ezelőtti földi körülményekre következtethetünk. Az utóbbi években a földkéregben felfedezett gazdag extremofil-társulások alapján megdőlni látszik az a hagyományos nézet, mely szerint Luca egy meleg felszíni pocsolyában tenyészett, s divatoss