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Sample records for involving ikkg nemo

  1. A comparative signaling cost analysis of Macro Mobility scheme in NEMO (MM-NEMO) with mobility management protocol

    Science.gov (United States)

    Islam, Shayla; Abdalla, Aisha H.; Habaebi, Mohamed H.; Latif, Suhaimi A.; Hassan, Wan H.; Hasan, Mohammad K.; Ramli, H. A. M.; Khalifa, Othman O.

    2013-12-01

    NEMO BSP is an upgraded addition to Mobile IPv6 (MIPv6). As MIPv6 and its enhancements (i.e. HMIPv6) possess some limitations like higher handoff latency, packet loss, NEMO BSP also faces all these shortcomings by inheritance. Network Mobility (NEMO) is involved to handle the movement of Mobile Router (MR) and it's Mobile Network Nodes (MNNs) during handoff. Hence it is essential to upgrade the performance of mobility management protocol to obtain continuous session connectivity with lower delay and packet loss in NEMO environment. The completion of handoff process in NEMO BSP usually takes longer period since MR needs to register its single primary care of address (CoA) with home network that may cause performance degradation of the applications running on Mobile Network Nodes. Moreover, when a change in point of attachment of the mobile network is accompanied by a sudden burst of signaling messages, "Signaling Storm" occurs which eventually results in temporary congestion, packet delays or even packet loss. This effect is particularly significant for wireless environment where a wireless link is not as steady as a wired link since bandwidth is relatively limited in wireless link. Hence, providing continuous Internet connection without any interruption through applying multihoming technique and route optimization mechanism in NEMO are becoming the center of attention to the current researchers. In this paper, we propose a handoff cost model to compare the signaling cost of MM-NEMO with NEMO Basic Support Protocol (NEMO BSP) and HMIPv6.The numerical results shows that the signaling cost for the MM-NEMO scheme is about 69.6 % less than the NEMO-BSP and HMIPv6.

  2. A comparative signaling cost analysis of Macro Mobility scheme in NEMO (MM-NEMO) with mobility management protocol

    International Nuclear Information System (INIS)

    Islam, Shayla; Abdalla, Aisha H; Habaebi, Mohamed H; Latif, Suhaimi A; Hassan, Wan H; Hasan, Mohammad K; Ramli, H A M; Khalifa, Othman O

    2013-01-01

    NEMO BSP is an upgraded addition to Mobile IPv6 (MIPv6). As MIPv6 and its enhancements (i.e. HMIPv6) possess some limitations like higher handoff latency, packet loss, NEMO BSP also faces all these shortcomings by inheritance. Network Mobility (NEMO) is involved to handle the movement of Mobile Router (MR) and it's Mobile Network Nodes (MNNs) during handoff. Hence it is essential to upgrade the performance of mobility management protocol to obtain continuous session connectivity with lower delay and packet loss in NEMO environment. The completion of handoff process in NEMO BSP usually takes longer period since MR needs to register its single primary care of address (CoA) with home network that may cause performance degradation of the applications running on Mobile Network Nodes. Moreover, when a change in point of attachment of the mobile network is accompanied by a sudden burst of signaling messages, ''Signaling Storm'' occurs which eventually results in temporary congestion, packet delays or even packet loss. This effect is particularly significant for wireless environment where a wireless link is not as steady as a wired link since bandwidth is relatively limited in wireless link. Hence, providing continuous Internet connection without any interruption through applying multihoming technique and route optimization mechanism in NEMO are becoming the center of attention to the current researchers. In this paper, we propose a handoff cost model to compare the signaling cost of MM-NEMO with NEMO Basic Support Protocol (NEMO BSP) and HMIPv6.The numerical results shows that the signaling cost for the MM-NEMO scheme is about 69.6 % less than the NEMO-BSP and HMIPv6

  3. RedNemo

    DEFF Research Database (Denmark)

    Alkan, Ferhat; Erten, Cesim

    2017-01-01

    is their erroneous nature; they contain false-positive interactions and usually many more false-negatives. Recently, several computational methods have been proposed for network reconstruction based on topology, where given an input PPI network the goal is to reconstruct the network by identifying false...... material including source code, useful scripts, experimental data and the results are available at http://webprs.khas.edu.tr/∼cesim/Red Nemo. tar.gz CONTACT: cesim@khas.edu.tr Supplementary information: Supplementary data are available at Bioinformatics online....

  4. Nemo-3 calorimeter electronics

    International Nuclear Information System (INIS)

    Bernaudin, P.; Cheikali, C.; Lavigne, B.; Richard, A.; Lebris, J.

    2000-11-01

    The calorimeter electronics of the NEMO-3 double beta decay experiment fulfills three functions: -energy measurement of the electrons by measuring the charge of the pulses, - time measurement, - fast first level triggering. The electronics of the 1940 Scintillator-PM modules is implemented as 40 '9U x 400 mm VME' boards of up to 51 channels. For each channel the analog signals conditioning is implemented as one SMD daughter board. Each board performs 12 bit charge measurements with 0.35 pC charge resolution, 12 bit time measurements with 50 ps time resolution and a fast analog multiplicity level for triggering. The total handling and conversion time for all the channels is less than 100 μs. The electronics will be presented as well as the test system. (authors)

  5. NEMO: A Stellar Dynamics Toolbox

    Science.gov (United States)

    Barnes, Joshua; Hut, Piet; Teuben, Peter

    2010-10-01

    NEMO is an extendible Stellar Dynamics Toolbox, following an Open-Source Software model. It has various programs to create, integrate, analyze and visualize N-body and SPH like systems, following the pipe and filter architecture. In addition there are various tools to operate on images, tables and orbits, including FITS files to export/import to/from other astronomical data reduction packages. A large growing fraction of NEMO has been contributed by a growing list of authors. The source code consist of a little over 4000 files and a little under 1,000,000 lines of code and documentation, mostly C, and some C++ and Fortran. NEMO development started in 1986 in Princeton (USA) by Barnes, Hut and Teuben. See also ZENO (ascl:1102.027) for the version that Barnes maintains.

  6. Expanding the substantial interactome of NEMO using protein microarrays.

    LENUS (Irish Health Repository)

    Fenner, Beau J

    2010-01-01

    Signal transduction by the NF-kappaB pathway is a key regulator of a host of cellular responses to extracellular and intracellular messages. The NEMO adaptor protein lies at the top of this pathway and serves as a molecular conduit, connecting signals transmitted from upstream sensors to the downstream NF-kappaB transcription factor and subsequent gene activation. The position of NEMO within this pathway makes it an attractive target from which to search for new proteins that link NF-kappaB signaling to additional pathways and upstream effectors. In this work, we have used protein microarrays to identify novel NEMO interactors. A total of 112 protein interactors were identified, with the most statistically significant hit being the canonical NEMO interactor IKKbeta, with IKKalpha also being identified. Of the novel interactors, more than 30% were kinases, while at least 25% were involved in signal transduction. Binding of NEMO to several interactors, including CALB1, CDK2, SAG, SENP2 and SYT1, was confirmed using GST pulldown assays and coimmunoprecipitation, validating the initial screening approach. Overexpression of CALB1, CDK2 and SAG was found to stimulate transcriptional activation by NF-kappaB, while SYT1 overexpression repressed TNFalpha-dependent NF-kappaB transcriptional activation in human embryonic kidney cells. Corresponding with this finding, RNA silencing of CDK2, SAG and SENP2 reduced NF-kappaB transcriptional activation, supporting a positive role for these proteins in the NF-kappaB pathway. The identification of a host of new NEMO interactors opens up new research opportunities to improve understanding of this essential cell signaling pathway.

  7. Study of the background neutron and gamma components of the ββ(0ν) decay in the NEMO2 prototype detector. Consequences for the NEMO3 detector

    International Nuclear Information System (INIS)

    Marquet, Christine

    1999-01-01

    Neutrinoless double beta decay ββ(0ν) is a test of physics beyond the Standard Model by involving the existence of a massive Majorana neutrino (ν = ν-bar). To try to observe such a process with a sensitivity of 0.1 eV on the neutrino effective mass ( ν >), NEMO collaboration build the NEMO3 detector, able to measure half-lives greater than 10 24 years, corresponding to a few detected events per year. For that, it is necessary to know and master all background sources. This work was first dedicated to the study of external (to the double beta source) background with crossing electrons recorded with NEMO2 prototype detector and then to the simulation of this background in NEMO3 detector. Comparison between NEMO2 data and results of gamma and neutron simulations for different shieldings, with and without neutron source, has allowed to determine background contributions of radon, thoron, 208 Tl contaminations in materials, photon flux produced in laboratory and neutrons. This study, which has required improvements in the MICAP neutron simulation code by developing a photon generator, proved that radiative capture of fast neutrons thermalized in the detector was the source of events in the energy domain of the ββ(0ν) signal. In order to reach the required sensitivity on ν > mass, it has been shown that both a neutron shielding and magnetic field are necessary for NEMO3 detector. (author) [fr

  8. Nor-ursodeoxycholic acid reverses hepatocyte-specific nemo-dependent steatohepatitis.

    Science.gov (United States)

    Beraza, Naiara; Ofner-Ziegenfuss, Lisa; Ehedego, Haksier; Boekschoten, Mark; Bischoff, Stephan C; Mueller, Michael; Trauner, Michael; Trautwein, Christian

    2011-03-01

    Hepatocyte-specific NEMO/NF-κB deleted mice (NEMO(Δhepa)) develop spontaneous non-alcoholic steatohepatitis (NASH). Free fatty acids and bile acids promote DR5 expression. TRAIL/NK cell-mediated activation of TRAIL-R2/DR5 plays an important role during acute injury in NEMO(Δhepa) mice. To inhibit the progression of NASH in the absence of hepatocyte-NEMO/NF-kB signaling. NEMOf/f and NEMO(Δhepa) mice were fed with a low-fat diet, and with two anticholestatic diets; UDCA and NorUDCA. The impact of these treatments on the progression of NASH was evaluated. We show that high expression of DR5 in livers from NEMO(Δhepa) mice is accompanied by an abundant presence of bile acids (BAs), misregulation of BA transporters and significant alteration of lipid metabolism-related genes. Additionally, mice lacking NEMO in hepatocytes spontaneously showed ductular response at young age. Unexpectedly, feeding of NEMO(Δhepa) mice with low-fat diet failed to improve chronic liver injury. Conversely, anti-cholestatic treatment with nor-ursodeoxycholic acid (NorUDCA), but not with ursodeoxycholic acid (UDCA), led to a significant attenuation of liver damage in NEMO(Δhepa) mice. The strong therapeutic effect of NorUDCA relied on a significant downregulation of LXR-dependent lipogenesis and the normalisation of BA metabolism through mechanisms involving cross-talk between Cyp7a1 and SHP. This was associated with the significant improvement of liver histology, NEMO(Δhepa)/NorUDCA-treated mice showed lower apoptosis and reduced CyclinD1 expression, indicating attenuation of the compensatory proliferative response to hepatocellular damage. Finally, fibrosis and ductular reaction markers were significantly reduced in NorUDCA-treated NEMO(Δhepa) mice. Overall, our work demonstrates the contribution of bile acids metabolism to the progression of NASH in the absence of hepatocyte-NF-kB through mechanisms involving DR5-apoptosis, inflammation and fibrosis. Our work suggests a potential

  9. Double hit of NEMO gene in preeclampsia.

    Directory of Open Access Journals (Sweden)

    Agata Sakowicz

    Full Text Available The precise etiology of preeclampsia is unknown. Family studies indicate that both genetic and environmental factors influence its development. One of these factors is NFkB, whose activation depends on NEMO (NFkB essential modulator. This is the first study to investigate the association between the existence of single nucleotide variant of the NEMO gene and the appearance of preeclampsia. A total of 151 women (72 preeclamptic women and 79 controls and their children were examined. Sanger sequencing was performed to identify variants in the NEMO gene in the preeclamptic mothers. The maternal identified variants were then sought in the studied groups of children, and in the maternal and child controls, using RFLP-PCR. Real-time RT-PCR was performed to assess NEMO gene expression in maternal blood, umbilical cord blood and placentas. The sequencing process indicated the existence of two different variants in the 3'UTR region of the NEMO gene of preeclamptic women (IKBKG:c.*368C>A and IKBKG:c.*402C>T. The simultaneous occurrence of the TT genotype in the mother and the TT genotype in the daughter or a T allele in the son increased the risk of preeclampsia development 2.59 fold. Additionally, we found that the configuration of maternal/fetal genotypes (maternal TT/ daughter TT or maternal TT/son T of IKBKG:c.*402C/T variant is associated with the level of NEMO gene expression. Our results showed that, the simultaneous occurrence of the maternal TT genotype (IKBKG:c.*402C>T variants and TT genotype in the daughter or T allele in the son correlates with the level of NEMO gene expression and increases the risk of preeclampsia development. Our observations may offer a new insight into the genetic etiology and pathogenesis of preeclampsia.

  10. Low background techniques for SuperNEMO

    International Nuclear Information System (INIS)

    Liu, Xin Ran; Mott, James

    2015-01-01

    The UK contribution to achieving the ultra-low background conditions required inside the detectors of the SuperNEMO experiment are described. A dedicated facility has been established for the screening and selection of materials through gamma ray spectroscopy using germanium detectors. Initial results from two detectors are shown. The radon level inside the SuperNEMO detector must be less than 150 μBq/m 3 in order to achieve the target sensitivity. A Radon Concentration Line (RnCL) has been developed capable of measuring radon levels in large gas volumes down to 5 μBq/m 3 , improving on standard state-of-the-art radon detectors by 3 orders of magnitude. The development, commissioning and first measurements of radon content using the RnCL are also presented. (paper)

  11. NEMO educational kit on micro-optics at the secondary school

    Science.gov (United States)

    Flores-Arias, M. T.; Bao-Varela, Carmen

    2014-07-01

    NEMO was the "Network of Excellence in Micro-Optics" granted in the "Sixth Framework Program" of the European Union. It aimed at providing Europe with a complete Micro-Optics food-chain, by setting up centers for optical modeling and design; measurement and instrumentation; mastering, prototyping and replication; integration and packaging and reliability and standardization. More than 300 researchers from 30 groups in 12 countries participated in the project. One of the objectives of NEMO was to spread excellence and disseminate knowledge on micro-optics and micro-photonics. To convince pupils, already from secondary school level on, about the crucial role of light and micro-optics and the opportunities this combination holds, several partners of NEMO had collaborate to create this Educational Kit. In Spain the partner involved in this aim was the "Microoptics and GRIN Optics Group" at the University of Santiago of Compostela (USC). The educational kits provided to the Secondary School were composed by two plastic cards with the following microoptical element: different kinds of diffractive optical elements or DOES and refractive optical elements or ROEs namely arrays of micro-lenses. The kit also included a DVD with a handbook for performing the experiments as well as a laser pointer source. This kit was distributed free of charge in the countries with partners in NEMO. In particular in Spain was offered to around 200 Secondary School Centers and only 80 answered accepting evaluate the kit.

  12. Spectral modeling of scintillator for the NEMO-3 and SuperNEMO detectors

    Energy Technology Data Exchange (ETDEWEB)

    Argyriades, J. [LAL, Universite Paris-Sud, CNRS/IN2P3, F-91405 Orsay (France); Arnold, R. [IPHC, Universite de Strasbourg, CNRS/IN2P3, F-67037 Strasbourg (France); Augier, C. [LAL, Universite Paris-Sud, CNRS/IN2P3, F-91405 Orsay (France); Baker, J. [INL, Idaho Falls, 83415 (United States); Barabash, A.S. [Institute of Theoretical and Experimental Physics, 117259 Moscow (Russian Federation); Bongrand, M.; Broudin-Bay, G. [LAL, Universite Paris-Sud, CNRS/IN2P3, F-91405 Orsay (France); Brudanin, V.B. [Joint Institute for Nuclear Research, 141980 Dubna (Russian Federation); Caffrey, A.J. [INL, Idaho Falls, 83415 (United States); Cebrian, S. [University of Zaragoza, C/ Pedro Cerbuna 12, 50009 Zaragoza (Spain); Chapon, A. [LPC Caen, ENSICAEN, Universite de Caen, CNRS/IN2P3, F-14032 Caen (France); Chauveau, E. [CNRS/IN2P3, Centre d' Etudes Nucleaires de Bordeaux Gradignan, UMR 5797, F-33175 Gradignan (France); Universite de Bordeaux, Centre d' Etudes Nucleaires de Bordeaux Gradignan, UMR 5797, F-33175 Gradignan (France); Dafni, Th. [University of Zaragoza, C/ Pedro Cerbuna 12, 50009 Zaragoza (Spain); Daraktchieva, Z. [University College London, WC1E 6BT London (United Kingdom); Diaz, J. [IFIC, CSIC - Universidad de Valencia, Valencia (Spain); Durand, D. [LPC Caen, ENSICAEN, Universite de Caen, CNRS/IN2P3, F-14032 Caen (France); Egorov, V.G. [Joint Institute for Nuclear Research, 141980 Dubna (Russian Federation); Evans, J.J. [University College London, WC1E 6BT London (United Kingdom); Fatemi-Ghomi, N. [University of Manchester, M13 9PL Manchester (United Kingdom); Flack, R. [University College London, WC1E 6BT London (United Kingdom)

    2011-01-01

    We have constructed a GEANT4-based detailed software model of photon transport in plastic scintillator blocks and have used it to study the NEMO-3 and SuperNEMO calorimeters employed in experiments designed to search for neutrinoless double beta decay. We compare our simulations to measurements using conversion electrons from a calibration source of {sup 207}Bi and show that the agreement is improved if wavelength-dependent properties of the calorimeter are taken into account. In this article, we briefly describe our modeling approach and results of our studies.

  13. Atmospheric muons in the NEMO Phase 1 detector at the Catania test site

    International Nuclear Information System (INIS)

    Margiotta, Annarita

    2006-01-01

    The NEMO Collaboration is involved in a long term R and D activity towards the construction of a km 3 telescope in the Mediterranean sea. It has dedicated special efforts in the development of technologies for a km 3 detector and in the search, characterization and monitoring of a deep sea site adequate for the installation of the Mediterranean km 3 . Now the NEMO Collaboration is involved in the Phase 1 of the project, planning to install a fully equipped deep-sea facility to test prototypes and develop new technologies for the detector. A full Monte Carlo simulation has been performed to analyse the response of a reduced-size detector to the passage of atmospheric muons. Preliminary steps of the simulation are presented in this work

  14. PORFIDO on the NEMO Phase 2 tower

    Energy Technology Data Exchange (ETDEWEB)

    Ciaffoni, Orlando; Cordelli, Marco; Habel, Roberto; Martini, Agnese; Trasatti, Luciano [INFN-Laboratori Nazionali di Frascati, Via E. Fermi 40, I-00044 Frascati (RM) (Italy)

    2014-11-18

    We have designed and built an underwater measurement system, PORFIDO (Physical Oceanography by RFID Outreach) to gather oceanographic data from the Optical Modules of a neutrino telescope with a minimum of disturbance to the main installation. PORFIDO is composed of a sensor glued to the outside of an Optical Module, in contact with seawater, and of a reader placed inside the sphere, facing the sensor. Data are transmitted to the reader through the glass by RFID and to shore in real time for periods of years. The sensor gathers power from the radio frequency, thus eliminating the need for batteries or connectors through the glass. We have deployed four PORFIDO probes measuring temperatures with the NEMO-KM3Net-Italy Phase 2 tower in april 2013. The four probes are operative and are transmitting temperature data from 3500 m depth.

  15. PORFIDO on the NEMO Phase 2 tower

    International Nuclear Information System (INIS)

    Ciaffoni, Orlando; Cordelli, Marco; Habel, Roberto; Martini, Agnese; Trasatti, Luciano

    2014-01-01

    We have designed and built an underwater measurement system, PORFIDO (Physical Oceanography by RFID Outreach) to gather oceanographic data from the Optical Modules of a neutrino telescope with a minimum of disturbance to the main installation. PORFIDO is composed of a sensor glued to the outside of an Optical Module, in contact with seawater, and of a reader placed inside the sphere, facing the sensor. Data are transmitted to the reader through the glass by RFID and to shore in real time for periods of years. The sensor gathers power from the radio frequency, thus eliminating the need for batteries or connectors through the glass. We have deployed four PORFIDO probes measuring temperatures with the NEMO-KM3Net-Italy Phase 2 tower in april 2013. The four probes are operative and are transmitting temperature data from 3500 m depth

  16. Advanced energy systems and technologies research in Finland. NEMO-2 Programme Annual Report 1996-1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-10-01

    Advanced energy technologies were linked to the national energy research in the beginning of 1988 when energy research was reorganised in Finland. The Ministry of Trade and Industry established several energy research programmes and NEMO was one of them. Major objectives of the programme were to assess the potential of new energy systems for the national energy supply system and to promote industrial activities. Within the NEMO 2 programme for the years 1993-1998, research was focused on a few promising technological solutions. In the beginning of 1995, the national energy research activities were passed on to the Technology Development Centre TEKES. The NEMO 2 programme is directed towards those areas that have particular potential for commercial exploitation or development. Emphasis is placed particularly on solar and wind energy, as well as supporting technologies, such as energy storage and hydrogen technology. Resources have been focused on three specific areas: arctic wind technology, wind turbine components, and the integration of solar energy into applications (including thin film solar cells). In Finland, the growth of the new energy technology industry is concentrated on these areas. The turnover of the Finnish industry has been growing considerably due to the national research activities and support of technology development. The sales have increased more than 10 times compared with the year 1987 and is now over 300 million FIM. The support to industries and their involvement in the program has grown considerably. In this report, the essential research projects of the programme during 1996-1997 are described. The total funding for these projects was about 30 million FIM per year, of which the TEKES`s share was about 40 per cent. The programme consists of 10 research projects, some 15 joint development projects, and 9 EU projects. In case the research projects and joint development projects are acting very closely, the description of the project is

  17. Advanced energy systems and technologies research in Finland. NEMO 2 annual report 1994-1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-31

    Advanced energy technologies were linked to the national energy research in beginning of 1988 when energy research was reorganised in Finland. The Ministry of Trade and Industry set up many energy research programmes and NEMO was one of them. Major objectives of the programme were to assess the potential of new energy systems for the national energy supply system and to promote industrial activities. Within the NEMO 2 programme for the years 1993-1998, research was focused on technological solutions. In the beginning of the 1995, the national energy research activities were passed on to the Technology Development Centre TEKES. The NEMO 2 programme is directed towards those areas that have particular potential for commercial exploitation or development. Emphasis is placed particularly on solar and wind energy, as well as supporting technologies such as energy storage and hydrogen technology. Resources has been focused on three specific areas: Arctic wind technology, wind turbine components, and the integration of solar energy into applications (including thin film solar cells). It seems that in Finland the growth of the new energy technology industry is focused on these areas. The sales of the industry have been growing considerable due to the national research activities and support of technology development. The sales have increased 6 - 7 times compared to the year 1987 and is now over 200 million FIM. The support to industries and their involvement in the program has grown more than 15 times compared to 1988. The total funding of the NEMO 2 program me was 30 million FIM in 1994 and 21 million FIM in 1995. The programme consists of 20 research projects, 15 joint development projects, and 5 EU projects. In this report, the essential research projects of the programme in 1994-1995 are described. The total funding for these projects was about 25 million FIM, of which the TEKES`s share was about half. When the research projects and joint development projects are

  18. Advanced energy systems and technologies research in Finland. NEMO-2 Programme Annual Report 1996-1997

    International Nuclear Information System (INIS)

    1998-01-01

    Advanced energy technologies were linked to the national energy research in the beginning of 1988 when energy research was reorganised in Finland. The Ministry of Trade and Industry established several energy research programmes and NEMO was one of them. Major objectives of the programme were to assess the potential of new energy systems for the national energy supply system and to promote industrial activities. Within the NEMO 2 programme for the years 1993-1998, research was focused on a few promising technological solutions. In the beginning of 1995, the national energy research activities were passed on to the Technology Development Centre TEKES. The NEMO 2 programme is directed towards those areas that have particular potential for commercial exploitation or development. Emphasis is placed particularly on solar and wind energy, as well as supporting technologies, such as energy storage and hydrogen technology. Resources have been focused on three specific areas: arctic wind technology, wind turbine components, and the integration of solar energy into applications (including thin film solar cells). In Finland, the growth of the new energy technology industry is concentrated on these areas. The turnover of the Finnish industry has been growing considerably due to the national research activities and support of technology development. The sales have increased more than 10 times compared with the year 1987 and is now over 300 million FIM. The support to industries and their involvement in the program has grown considerably. In this report, the essential research projects of the programme during 1996-1997 are described. The total funding for these projects was about 30 million FIM per year, of which the TEKES's share was about 40 per cent. The programme consists of 10 research projects, some 15 joint development projects, and 9 EU projects. In case the research projects and joint development projects are acting very closely, the description of the project is

  19. Development of quantum device simulator NEMO-VN1

    Science.gov (United States)

    Hien, Dinh Sy; Thi Luong, Nguyen; Hoang Minh, Le; Tien Phuc, Tran; Thanh Trung, Pham; Dong, Bui An; Thu Thao, Huynh Lam; Van Le Thanh, Nguyen; Tuan, Thi Tran Anh; Hoang Trung, Huynh; Thi Thanh Nhan, Nguyen; Viet Nga, Dinh

    2009-09-01

    We have developed NEMO-VN1 (NanoElectronic MOdelling), a new modelling tool that simulates a wide variety of quantum devices including Quantum Dot (QD), Resonant Tunneling Diode (RTD), Resonant Tunneling Transistor (RTT), Single Electron Transistor (SET), Molecular FET (MFET), Carbon Nanotube FET (CNTFET), Spin FET (SPINFET). It has a collection of models that allow user to trade off between calculation speed and accuracy. NEMO-VN1 also includes a graphic user interface of Matlab that enables parameter entry, calculation control, intuitive display of calculation results, and in-situ data analysis methods.

  20. Development of quantum device simulator NEMO-VN1

    International Nuclear Information System (INIS)

    Dinh Sy Hien; Nguyen Thi Luong; Le Hoang Minh; Tran Tien Phuc; Pham Thanh Trung; Bui An Dong; Huynh Lam Thu Thao; Nguyen Van Le Thanh; Thi Tran Anh Tuan; Huynh Hoang Trung; Nguyen Thi Thanh Nhan; Dinh Viet Nga

    2009-01-01

    We have developed NEMO-VN1 (NanoElectronic MOdelling), a new modelling tool that simulates a wide variety of quantum devices including Quantum Dot (QD), Resonant Tunneling Diode (RTD), Resonant Tunneling Transistor (RTT), Single Electron Transistor (SET), Molecular FET (MFET), Carbon Nanotube FET (CNTFET), Spin FET (SPINFET). It has a collection of models that allow user to trade off between calculation speed and accuracy. NEMO-VN1 also includes a graphic user interface of Matlab that enables parameter entry, calculation control, intuitive display of calculation results, and in-situ data analysis methods.

  1. Neutrino Physics without Neutrinos: Recent results from the NEMO-3 experiment and plans for SuperNEMO

    CERN Multimedia

    CERN. Geneva

    2015-01-01

    The observation of neutrino oscillations has proved that neutrinos have mass. This discovery has renewed and strengthened the interest in neutrinoless double beta decay experiments which provide the only practical way to determine whether neutrinos are Majorana or Dirac particles. The recently completed NEMO-3 experiment, located in the Laboratoire Souterrain de Modane in the Frejus Tunnel, was an experiment searching for neutrinoless double beta decays using a powerful technique for detecting a two-electron final state by employing an apparatus combining tracking, calorimetry, and the time-of-flight measurements. We will present latest results from NEMO-3 and will discuss the status of SuperNEMO, the next generation experiment that will exploit the same experimental technique to extend the sensitivity of the current search.

  2. Evaluation of QoS supported in Network Mobility NEMO environments

    International Nuclear Information System (INIS)

    Hussien, L F; Abdalla, A H; Habaebi, M H; Khalifa, O O; Hassan, W H

    2013-01-01

    Network mobility basic support (NEMO BS) protocol is an entire network, roaming as a unit which changes its point of attachment to the Internet and consequently its reachability in the network topology. NEMO BS doesn't provide QoS guarantees to its users same as traditional Internet IP and Mobile IPv6 as well. Typically, all the users will have same level of services without considering about their application requirements. This poses a problem to real-time applications that required QoS guarantees. To gain more effective control of the network, incorporated QoS is needed. Within QoS-enabled network the traffic flow can be distributed to various priorities. Also, the network bandwidth and resources can be allocated to different applications and users. Internet Engineering Task Force (IETF) working group has proposed several QoS solutions for static network such as IntServ, DiffServ and MPLS. These QoS solutions are designed in the context of a static environment (i.e. fixed hosts and networks). However, they are not fully adapted to mobile environments. They essentially demands to be extended and adjusted to meet up various challenges involved in mobile environments. With existing QoS mechanisms many proposals have been developed to provide QoS for individual mobile nodes (i.e. host mobility). In contrary, research based on the movement of the whole mobile network in IPv6 is still undertaking by the IETF working groups (i.e. network mobility). Few researches have been done in the area of providing QoS for roaming networks. Therefore, this paper aims to review and investigate (previous /and current) related works that have been developed to provide QoS in mobile network. Consequently, a new proposed scheme will be introduced to enhance QoS within NEMO environment, achieving by which seamless mobility to users of mobile network node (MNN)

  3. BAHAN AJAR MENULIS CERITA FABEL DENGAN STIMULUS FILM FINDING NEMO

    Directory of Open Access Journals (Sweden)

    Lia Noviana Qostantia

    2017-03-01

    Full Text Available This research objectives were (1 describing instructional material of writing fable story using stimulus of finding nemo movie and (2 describing instructional material feasibility of writing fable story using stimulus of Finding Nemo movie that obtained from expert test and practitioner (teacher and student test. The developed instructional material was complementary book of writing fable story for students with material, language, and book display that adjusted with student’s needs. Those objectives could be made as guidance in developing the instructional material which including material content feasibility, language, and complementary book display aspect. Tujuan penelitian ini adalah (1 mengembangkan bahan ajar menulis cerita fabel dengan stimulus film finding nemo, (2 mendeskripsikan kelayakan bahan ajar menulis cerita fabel dengan stimulus film Finding Nemo yang diperoleh dari uji ahli, uji praktisi guru, dan siswa. Bahan ajar yang dikembangkan berupa buku pelengkap menulis cerita fabel untuk siswa dengan materi, bahasa, dan penyajian buku yang disesuaikan dengan kebutuhan siswa. Tujuan tersebut dapat dijadikan panduan dalam mengembangkan bahan ajar yang mencakup aspek kelayakan isi materi, bahasa, dan penyajian buku pelengkap.

  4. Quantification of cellular NEMO content and its impact on NF-κB activation by genotoxic stress.

    Directory of Open Access Journals (Sweden)

    Byounghoon Hwang

    Full Text Available NF-κB essential modulator, NEMO, plays a key role in canonical NF-κB signaling induced by a variety of stimuli, including cytokines and genotoxic agents. To dissect the different biochemical and functional roles of NEMO in NF-κB signaling, various mutant forms of NEMO have been previously analyzed. However, transient or stable overexpression of wild-type NEMO can significantly inhibit NF-κB activation, thereby confounding the analysis of NEMO mutant phenotypes. What levels of NEMO overexpression lead to such an artifact and what levels are tolerated with no significant impact on NEMO function in NF-κB activation are currently unknown. Here we purified full-length recombinant human NEMO protein and used it as a standard to quantify the average number of NEMO molecules per cell in a 1.3E2 NEMO-deficient murine pre-B cell clone stably reconstituted with full-length human NEMO (C5. We determined that the C5 cell clone has an average of 4 x 10(5 molecules of NEMO per cell. Stable reconstitution of 1.3E2 cells with different numbers of NEMO molecules per cell has demonstrated that a 10-fold range of NEMO expression (0.6-6x10(5 molecules per cell yields statistically equivalent NF-κB activation in response to the DNA damaging agent etoposide. Using the C5 cell line, we also quantified the number of NEMO molecules per cell in several commonly employed human cell lines. These results establish baseline numbers of endogenous NEMO per cell and highlight surprisingly normal functionality of NEMO in the DNA damage pathway over a wide range of expression levels that can provide a guideline for future NEMO reconstitution studies.

  5. NEMO: Extraction and normalization of organization names from PubMed affiliations.

    Science.gov (United States)

    Jonnalagadda, Siddhartha Reddy; Topham, Philip

    2010-10-04

    Today, there are more than 18 million articles related to biomedical research indexed in MEDLINE, and information derived from them could be used effectively to save the great amount of time and resources spent by government agencies in understanding the scientific landscape, including key opinion leaders and centers of excellence. Associating biomedical articles with organization names could significantly benefit the pharmaceutical marketing industry, health care funding agencies and public health officials and be useful for other scientists in normalizing author names, automatically creating citations, indexing articles and identifying potential resources or collaborators. Large amount of extracted information helps in disambiguating organization names using machine-learning algorithms. We propose NEMO, a system for extracting organization names in the affiliation and normalizing them to a canonical organization name. Our parsing process involves multi-layered rule matching with multiple dictionaries. The system achieves more than 98% f-score in extracting organization names. Our process of normalization that involves clustering based on local sequence alignment metrics and local learning based on finding connected components. A high precision was also observed in normalization. NEMO is the missing link in associating each biomedical paper and its authors to an organization name in its canonical form and the Geopolitical location of the organization. This research could potentially help in analyzing large social networks of organizations for landscaping a particular topic, improving performance of author disambiguation, adding weak links in the co-author network of authors, augmenting NLM's MARS system for correcting errors in OCR output of affiliation field, and automatically indexing the PubMed citations with the normalized organization name and country. Our system is available as a graphical user interface available for download along with this paper.

  6. Naval EarthMap Observer (NEMO) science and naval products

    Science.gov (United States)

    Davis, Curtiss O.; Kappus, Mary E.; Gao, Bo-Cai; Bissett, W. Paul; Snyder, William A.

    1998-11-01

    A wide variety of applications of imaging spectrometry have been demonstrated using data from aircraft systems. Based on this experience the Navy is pursuing the Hyperspectral Remote Sensing Technology (HRST) Program to use hyperspectral imagery to characterize the littoral environment, for scientific and environmental studies and to meet Naval needs. To obtain the required space based hyperspectral imagery the Navy has joined in a partnership with industry to build and fly the Naval EarthMap Observer (NEMO). The NEMO spacecraft has the Coastal Ocean Imaging Spectrometer (COIS) a hyperspectral imager with adequate spectral and spatial resolution and a high signal-to- noise ratio to provide long term monitoring and real-time characterization of the coastal environment. It includes on- board processing for rapid data analysis and data compression, a large volume recorder, and high speed downlink to handle the required large volumes of data. This paper describes the algorithms for processing the COIS data to provide at-launch ocean data products and the research and modeling that are planned to use COIS data to advance our understanding of the dynamics of the coastal ocean.

  7. NEMO binds ubiquitinated TANK-binding kinase 1 (TBK1 to regulate innate immune responses to RNA viruses.

    Directory of Open Access Journals (Sweden)

    Lingyan Wang

    Full Text Available RIG-I-like receptors (RLR are intracellular sensors utilized by nearly all cell types for recognition of viral RNA, initiation of antiviral defense, and induction of type I interferons (IFN. TBK1 is a critical kinase implicated in RLR-dependent IFN transcription. Posttranslational modification of TBK1 by K63-linked ubiquitin is required for RLR driven signaling. However, the TBK1 ubiquitin acceptor sites and the function of ubiquitinated TBK1 in the signaling cascade are unknown. We now show that TBK1 is ubiquitinated on residues K69, K154, and K372 in response to infection with RNA virus. The K69 and K154 residues are critical for innate antiviral responses and IFN production. Ubiquitinated TBK1 recruits the downstream adaptor NEMO through ubiquitin binding domains. The assembly of the NEMO/TBK1 complex on the mitochondrial protein MAVS leads to activation of TBK1 kinase activity and phosphorylation of the transcription factor, interferon response factor 3. The combined results refine current views of RLR signaling, define the role of TBK1 polyubiquitination, and detail the mechanisms involved in signalosome assembly.

  8. GeNemo: a search engine for web-based functional genomic data.

    Science.gov (United States)

    Zhang, Yongqing; Cao, Xiaoyi; Zhong, Sheng

    2016-07-08

    A set of new data types emerged from functional genomic assays, including ChIP-seq, DNase-seq, FAIRE-seq and others. The results are typically stored as genome-wide intensities (WIG/bigWig files) or functional genomic regions (peak/BED files). These data types present new challenges to big data science. Here, we present GeNemo, a web-based search engine for functional genomic data. GeNemo searches user-input data against online functional genomic datasets, including the entire collection of ENCODE and mouse ENCODE datasets. Unlike text-based search engines, GeNemo's searches are based on pattern matching of functional genomic regions. This distinguishes GeNemo from text or DNA sequence searches. The user can input any complete or partial functional genomic dataset, for example, a binding intensity file (bigWig) or a peak file. GeNemo reports any genomic regions, ranging from hundred bases to hundred thousand bases, from any of the online ENCODE datasets that share similar functional (binding, modification, accessibility) patterns. This is enabled by a Markov Chain Monte Carlo-based maximization process, executed on up to 24 parallel computing threads. By clicking on a search result, the user can visually compare her/his data with the found datasets and navigate the identified genomic regions. GeNemo is available at www.genemo.org. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

  9. Disulfide-mediated stabilization of the IκB kinase binding domain of NF-κB essential modulator (NEMO).

    Science.gov (United States)

    Zhou, Li; Yeo, Alan T; Ballarano, Carmine; Weber, Urs; Allen, Karen N; Gilmore, Thomas D; Whitty, Adrian

    2014-12-23

    Human NEMO (NF-κB essential modulator) is a 419 residue scaffolding protein that, together with catalytic subunits IKKα and IKKβ, forms the IκB kinase (IKK) complex, a key regulator of NF-κB pathway signaling. NEMO is an elongated homodimer comprising mostly α-helix. It has been shown that a NEMO fragment spanning residues 44-111, which contains the IKKα/β binding site, is structurally disordered in the absence of bound IKKβ. Herein we show that enforcing dimerization of NEMO1-120 or NEMO44-111 constructs through introduction of one or two interchain disulfide bonds, through oxidation of the native Cys54 residue and/or at position 107 through a Leu107Cys mutation, induces a stable α-helical coiled-coil structure that is preorganized to bind IKKβ with high affinity. Chemical and thermal denaturation studies showed that, in the context of a covalent dimer, the ordered structure was stabilized relative to the denatured state by up to 3 kcal/mol. A full-length NEMO-L107C protein formed covalent dimers upon treatment of mammalian cells with H2O2. Furthermore, NEMO-L107C bound endogenous IKKβ in A293T cells, reconstituted TNF-induced NF-κB signaling in NEMO-deficient cells, and interacted with TRAF6. Our results indicate that the IKKβ binding domain of NEMO possesses an ordered structure in the unbound state, provided that it is constrained within a dimer as is the case in the constitutively dimeric full-length NEMO protein. The stability of the NEMO coiled coil is maintained by strong interhelix interactions in the region centered on residue 54. The disulfide-linked constructs we describe herein may be useful for crystallization of NEMO's IKKβ binding domain in the absence of bound IKKβ, thereby facilitating the structural characterization of small-molecule inhibitors.

  10. Epithelial NEMO/IKKγ limits fibrosis and promotes regeneration during pancreatitis.

    Science.gov (United States)

    Chan, Lap Kwan; Gerstenlauer, Melanie; Konukiewitz, Björn; Steiger, Katja; Weichert, Wilko; Wirth, Thomas; Maier, Harald Jakob

    2017-11-01

    Inhibitory κB kinase (IKK)/nuclear factor κB (NF-κB) signalling has been implicated in the pathogenesis of pancreatitis, but its precise function has remained controversial. Here, we analyse the contribution of IKK/NF-κB signalling in epithelial cells to the pathogenesis of pancreatitis by targeting the IKK subunit NF-κB essential modulator (NEMO) (IKKγ), which is essential for canonical NF-κB activation. Mice with a targeted deletion of NEMO in the pancreas were subjected to caerulein pancreatitis. Pancreata were examined at several time points and analysed for inflammation, fibrosis, cell death, cell proliferation, as well as cellular differentiation. Human samples were used to corroborate findings established in mice. In acute pancreatitis, NEMO deletion in the pancreatic parenchyma resulted in minor changes during the early phase but led to the persistence of inflammatory and fibrotic foci in the recovery phase. In chronic pancreatitis, NEMO deletion aggravated inflammation and fibrosis, inhibited compensatory acinar cell proliferation, and enhanced acinar atrophy and acinar-ductal metaplasia. Gene expression analysis revealed sustained activation of profibrogenic genes and the CXCL12/CXCR4 axis in the absence of epithelial NEMO. In human chronic pancreatitis samples, the CXCL12/CXCR4 axis was activated as well, with CXCR4 expression correlating with the degree of fibrosis. The aggravating effects of NEMO deletion were attenuated by the administration of the CXCR4 antagonist AMD3100. Our results suggest that NEMO in epithelial cells exerts a protective effect during pancreatitis by limiting inflammation and fibrosis and improving acinar cell regeneration. The CXCL12/CXCR4 axis is an important mediator of that effect and may also be of importance in human chronic pancreatitis. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  11. NEMO 2 - Be aware: Wind and solar are coming

    Energy Technology Data Exchange (ETDEWEB)

    Lund, P. [Helsinki Univ. of Technology, Otaniemi (Finland)

    1996-12-31

    Finnish research and development is well placed with respect to new renewable energy technologies in that there exists considerable expertise in specialized areas. For example, over 20 % of all power transmission equipment and generators used in wind energy systems world-wide are manufactured in Finland, while advanced instruments for monitoring wind speed are also highly regarded internationally. Moreover, unique wind technology for complex windy and freezing conditions have been developed. Finland has a 10 % share in the European photovoltaic market, and has competitive advantages in photovoltaic systems and applications, thin film solar cells, and automated electronic controlling systems. A unique solar energy storage system based on hydrogen technology demonstrates skills on overcoming the summer-winter syndrome of large-scale solar energy utilization. The annual turnover of the Finnish industries on solar and wind energy has increased from 5 million ECU in 1988 to almost 50 million ECU in 1996. The national R and D and D from 1988 onwards has played an important role in this context. Most of the research and development into new and renewable energy technologies in Finland has been carried out through the Advanced New Energy Systems and Technologies Research Programme (NEMO2) of Tekes

  12. Porcine deltacoronavirus nsp5 inhibits interferon-β production through the cleavage of NEMO.

    Science.gov (United States)

    Zhu, Xinyu; Fang, Liurong; Wang, Dang; Yang, Yuting; Chen, Jiyao; Ye, Xu; Foda, Mohamed Frahat; Xiao, Shaobo

    2017-02-01

    Porcine deltacoronavirus (PDCoV) causes acute enteric disease and mortality in seronegative neonatal piglets. Previously we have demonstrated that PDCoV infection suppresses the production of interferon-beta (IFN-β), while the detailed mechanisms are poorly understood. Here, we demonstrate that nonstructural protein 5 (nsp5) of PDCoV, the 3C-like protease, significantly inhibits Sendai virus (SEV)-induced IFN-β production by targeting the NF-κB essential modulator (NEMO), confirmed by the diminished function of NEMO cleaved by PDCoV. The PDCoV nsp5 cleavage site in the NEMO protein was identified as glutamine 231, and was identical to the porcine epidemic diarrhea virus nsp5 cleavage site, revealing the likelihood of a common target in NEMO for coronaviruses. Furthermore, this cleavage impaired the ability of NEMO to activate the IFN response and downstream signaling. Taken together, our findings reveal PDCoV nsp5 to be a newly identified IFN antagonist and enhance the understanding of immune evasion by deltacoronaviruses. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. Nemo-3 experiment assets and limitations. Perspective for the double β physics

    International Nuclear Information System (INIS)

    Augier, C.

    2005-06-01

    After an introduction to this report in Chapter 1, I present a status of our knowledge in neutrino physics in Chapter 2. Then, I detail in Chapter 3 all the choices made for the design and realisation of the NEMO 3 detector for the research of double beta decay process. Performance of the detector is presented, concerning both the capacity of the detector to identify the backgrounds and the ability to study all the ββ process. I also explain the methods chosen by the NEMO collaboration to reduce the radon activity inside the detector and to make this background negligible today. This chapter, which is written in English, is the 'Technical report of the NEMO 3 detector' and forms an independent report for the NEMO collaborators. I finish this report in Chapter 4 with a ten years prospect for experimental projects in physics, with both the SuperNEMO project and its experiment program, and also by comparing the most interesting experiments, CUORE and GERDA, showing as an example the effect of nuclear matrix elements on the neutrino effective mass measurement. (author)

  14. Review paper of gateway selection schemes for MANET of NEMO (MANEMO)

    International Nuclear Information System (INIS)

    Mahmood, Z; Hashim, A; Khalifa, O; Anwar, F; Hameed, S

    2013-01-01

    The fast growth of Internet applications brings with it new challenges for researchers to provide new solutions that guarantee better Internet access for mobile hosts and networks. The globally reachable, Home-Agent based, infrastructure Network Mobility (NEMO) and the local, multi-hop, and infrastructure-less Mobile Ad hoc Network (MANET) developed by Internet Engineering Task Force (IETF) support different topologies of the mobile networks. A new architecture was proposed by combining both topologies to obtain Mobile Ad Hoc NEMO (MANEMO). However, the integration of NEMO and MANET introduces many challenges such as network loops, sub-optimal route, redundant tunnel problem, absence of communication without Home Agent reachability, and exit router selection when multiple Exit Routers to the Internet exist. This paper aims to review the different proposed models that could be used to implement the gateway selection mechanism and it highlights the strengths as well as the limitations of these approaches

  15. Withaferin A disrupts ubiquitin-based NEMO reorganization induced by canonical NF-κB signaling

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, Shawn S. [McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, 6159 Wisconsin Institute for Medical Research, 1111 Highland Avenue, Madison, WI 53705 (United States); Medical Scientist Training Program, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, WI 53705 (United States); Cellular and Molecular Biology Program, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, WI 53705 (United States); Oberley, Christopher [McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, 6159 Wisconsin Institute for Medical Research, 1111 Highland Avenue, Madison, WI 53705 (United States); Hooper, Christopher P. [McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, 6159 Wisconsin Institute for Medical Research, 1111 Highland Avenue, Madison, WI 53705 (United States); Cellular and Molecular Biology Program, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, WI 53705 (United States); Grindle, Kreg [Department of Medicine, Division of Hematology and Oncology, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, WI 53705 (United States); Wuerzberger-Davis, Shelly [McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, 6159 Wisconsin Institute for Medical Research, 1111 Highland Avenue, Madison, WI 53705 (United States); Wolff, Jared [Department of Medicine, Division of Hematology and Oncology, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, WI 53705 (United States); and others

    2015-02-01

    The NF-κB family of transcription factors regulates numerous cellular processes, including cell proliferation and survival responses. The constitutive activation of NF-κB has also emerged as an important oncogenic driver in many malignancies, such as activated B-cell like diffuse large B cell lymphoma, among others. In this study, we investigated the impact and mechanisms of action of Withaferin A, a naturally produced steroidal lactone, against both signal-inducible as well as constitutive NF-κB activities. We found that Withaferin A is a robust inhibitor of canonical and constitutive NF-κB activities, leading to apoptosis of certain lymphoma lines. In the canonical pathway induced by TNF, Withaferin A did not disrupt RIP1 polyubiquitination or NEMO–IKKβ interaction and was a poor direct IKKβ inhibitor, but prevented the formation of TNF-induced NEMO foci which colocalized with TNF ligand. While GFP-NEMO efficiently formed TNF-induced foci, a GFP-NEMO{sup Y308S} mutant that is defective in binding to polyubiquitin chains did not form foci. Our study reveals that Withaferin A is a novel type of IKK inhibitor which acts by disrupting NEMO reorganization into ubiquitin-based signaling structures in vivo. - Highlights: • Withaferin A, a NF-κB inhibitor, disrupts signaling induced NEMO localization, a novel point of inhibition. • NEMO can be localized to distinct signaling foci after treatment with TNF. • ABC-type DLCBL cells can be sensitized to apoptosis after treatment with Withaferin A.

  16. Background constrains of the SuperNEMO experiment for neutrinoless double beta-decay searches

    Energy Technology Data Exchange (ETDEWEB)

    Povinec, Pavel P.

    2017-02-11

    The SuperNEMO experiment is a new generation of experiments dedicated to the search for neutrinoless double beta-decay, which if observed, would confirm the existence of physics beyond the Standard Model. It is based on the tracking and calorimetry techniques, which allow the reconstruction of the final state topology, including timing and kinematics of the double beta-decay transition events, offering a powerful tool for background rejection. While the basic detection strategy of the SuperNEMO detector remains the same as of the NEMO-3 detector, a number of improvements were accomplished for each of detector main components. Upgrades of the detector technologies and development of low-level counting techniques ensure radiopurity control of construction parts of the SuperNEMO detector. A reference material made of glass pellets has been developed to assure quality management and quality control of radiopurity measurements. The first module of the SuperNEMO detector (Demonstrator) is currently under construction in the Modane underground laboratory. No background event is expected in the neutrinoless double beta-decay region in 2.5 years of its operation using 7 kg of {sup 82}Se. The half-life sensitivity of the Demonstrator is expected to be >6.5·10{sup 24} y, corresponding to an effective Majorana neutrino mass sensitivity of |0.2−0.4| eV (90% C.L.). The full SuperNEMO experiment comprising of 20 modules with 100 kg of {sup 82}Se source should reach an effective Majorana neutrino mass sensitivity of |0.04−0.1| eV, and a half-life limit 1·10{sup 26} y. - Highlights: • SuperNEMO detector for 2β0ν-decay of {sup 82}Se should reach half-life limit of 10{sup 26} y. • Radiopurity of the SuperNEMO internal detector parts was checked down to 0.1 mBq/kg. • Reference material of glass pellets was developed for underground γ-spectrometry.

  17. Strategy of HPGe screening measurements in the SuperNEMO experiment

    Energy Technology Data Exchange (ETDEWEB)

    Perrot, Frédéric [Université de Bordeaux, Centre d' Etudes Nucléaires de Bordeaux Gradignan, UMR 5797, Chemin du Solarium, Le Haut-Vigneau, BP120, F-33175 Gradignan, France and CNRS/IN2P3, Centre d' Etudes Nucléaires de Bordeaux Gradignan, UMR 5797 (France); Collaboration: SuperNEMO Collaboration

    2013-08-08

    SuperNEMO is a double beta decay experiment that will use a tracko-calorimeter technique. The goal is to reach a sensitivity of T{sub 1/2}(0ν)>10{sup 26} y corresponding to an effective Majorana neutrino mass of 0.04-0.11 eV with 100 kg of {sup 82}Se. The general strategy of the HPGe screening measurements is described for the materials of the SuperNEMO demonstrator, regarding their radiopurity and their location. The two platforms, PRISNA and LSM, used for this screening are also briefly described.

  18. NEMO. Netherlands Energy demand MOdel. A top-down model based on bottom-up information

    International Nuclear Information System (INIS)

    Koopmans, C.C.; Te Velde, D.W.; Groot, W.; Hendriks, J.H.A.

    1999-06-01

    The title model links energy use to other production factors, (physical) production, energy prices, technological trends and government policies. It uses a 'putty-semiputty' vintage production structure, in which new investments, adaptations to existing capital goods (retrofit) and 'good-housekeeping' are discerned. Price elasticities are relatively large in the long term and small in the short term. Most predictions of energy use are based on either econometric models or on 'bottom-up information', i.e. disaggregated lists of technical possibilities for and costs of saving energy. Typically, one predicts more energy-efficiency improvements using bottom-up information than using econometric ('top-down') models. We bridged this so-called 'energy-efficiency gap' by designing our macro/meso model NEMO in such a way that we can use bottom-up (micro) information to estimate most model parameters. In our view, reflected in NEMO, the energy-efficiency gap arises for two reasons. The first is that firms and households use a fairly high discount rate of 15% when evaluating the profitability of energy-efficiency improvements. The second is that our bottom-up information ('ICARUS') for most economic sectors does not (as NEMO does) take account of the fact that implementation of new, energy-efficient technology in capital stock takes place only gradually. Parameter estimates for 19 sectors point at a long-term technological energy efficiency improvement trend in Netherlands final energy use of 0.8% per year. The long-term price elasticity is estimated to be 0.29. These values are comparable to other studies based on time series data. Simulations of the effects of the oil price shocks in the seventies and the subsequent fall of oil prices show that the NEMO's price elasticities are consistent with historical data. However, the present pace at which new technologies become available (reflected in NEMO) appears to be lower than in the seventies and eighties. This suggests that it

  19. Advanced energy systems and technologies (NEMO 2). Final report 1993-1998

    Energy Technology Data Exchange (ETDEWEB)

    Lund, P.; Konttinen, P. [eds.

    1998-12-31

    NEMO2 has been the major Finnish energy research programme on advanced energy systems and technologies during 1993-1998. The main objective of the programme has been to support industrial technology development but also to increase the utilisation of wind and solar energy in Finland. The main technology fields covered are wind and solar energy. In addition, the programme has supported projects on energy storage and other small-scale energy technologies such as fuel cells that support the main technology fields chosen. NEMO2 is one of the energy research programmes of the Technology Development Centre of Finland (TEKES). The total R and D funding over the whole programme period was FIM 130 million (ECU 22 million). The public funding of the total programme costs has been 43 %. The industrial participation has been strong. International co-operation has been an important aspect in NEMO2: the programme has stimulated 24 EU-projects and participation in several IEA co-operative tasks. International funding adds nearly 20 % to the NEMO2 R and D funding. (orig.)

  20. AlignNemo: a local network alignment method to integrate homology and topology.

    Directory of Open Access Journals (Sweden)

    Giovanni Ciriello

    Full Text Available Local network alignment is an important component of the analysis of protein-protein interaction networks that may lead to the identification of evolutionary related complexes. We present AlignNemo, a new algorithm that, given the networks of two organisms, uncovers subnetworks of proteins that relate in biological function and topology of interactions. The discovered conserved subnetworks have a general topology and need not to correspond to specific interaction patterns, so that they more closely fit the models of functional complexes proposed in the literature. The algorithm is able to handle sparse interaction data with an expansion process that at each step explores the local topology of the networks beyond the proteins directly interacting with the current solution. To assess the performance of AlignNemo, we ran a series of benchmarks using statistical measures as well as biological knowledge. Based on reference datasets of protein complexes, AlignNemo shows better performance than other methods in terms of both precision and recall. We show our solutions to be biologically sound using the concept of semantic similarity applied to Gene Ontology vocabularies. The binaries of AlignNemo and supplementary details about the algorithms and the experiments are available at: sourceforge.net/p/alignnemo.

  1. Advanced energy systems and technologies (NEMO 2). Final report 1993-1998

    International Nuclear Information System (INIS)

    Lund, P.; Konttinen, P.

    1998-01-01

    NEMO2 has been the major Finnish energy research programme on advanced energy systems and technologies during 1993-1998. The main objective of the programme has been to support industrial technology development but also to increase the utilisation of wind and solar energy in Finland. The main technology fields covered are wind and solar energy. In addition, the programme has supported projects on energy storage and other small-scale energy technologies such as fuel cells that support the main technology fields chosen. NEMO2 is one of the energy research programmes of the Technology Development Centre of Finland (TEKES). The total R and D funding over the whole programme period was FIM 130 million (ECU 22 million). The public funding of the total programme costs has been 43 %. The industrial participation has been strong. International co-operation has been an important aspect in NEMO2: the programme has stimulated 24 EU-projects and participation in several IEA co-operative tasks. International funding adds nearly 20 % to the NEMO2 R and D funding. (orig.)

  2. Cellular automaton and elastic net for event reconstruction in the NEMO-2 experiment

    International Nuclear Information System (INIS)

    Kovalenko, V.

    1997-01-01

    A cellular automaton for track searching and an elastic net for charged particle trajectory fitting are presented. The advantages of the methods are: simplicity of the algorithms, fast and stable convergence to real tracks, and a reconstruction efficiency close to 100%. Demonstration programs are available at http://nuweb.jinr.dubna.su/LNP/NEMO using a Java enabled browser. (orig.)

  3. Surface wave effects in the NEMO ocean model: Forced and coupled experiments

    Science.gov (United States)

    Breivik, Øyvind; Mogensen, Kristian; Bidlot, Jean-Raymond; Balmaseda, Magdalena Alonso; Janssen, Peter A. E. M.

    2015-04-01

    The NEMO general circulation ocean model is extended to incorporate three physical processes related to ocean surface waves, namely the surface stress (modified by growth and dissipation of the oceanic wavefield), the turbulent kinetic energy flux from breaking waves, and the Stokes-Coriolis force. Experiments are done with NEMO in ocean-only (forced) mode and coupled to the ECMWF atmospheric and wave models. Ocean-only integrations are forced with fields from the ERA-Interim reanalysis. All three effects are noticeable in the extratropics, but the sea-state-dependent turbulent kinetic energy flux yields by far the largest difference. This is partly because the control run has too vigorous deep mixing due to an empirical mixing term in NEMO. We investigate the relation between this ad hoc mixing and Langmuir turbulence and find that it is much more effective than the Langmuir parameterization used in NEMO. The biases in sea surface temperature as well as subsurface temperature are reduced, and the total ocean heat content exhibits a trend closer to that observed in a recent ocean reanalysis (ORAS4) when wave effects are included. Seasonal integrations of the coupled atmosphere-wave-ocean model consisting of NEMO, the wave model ECWAM, and the atmospheric model of ECMWF similarly show that the sea surface temperature biases are greatly reduced when the mixing is controlled by the sea state and properly weighted by the thickness of the uppermost level of the ocean model. These wave-related physical processes were recently implemented in the operational coupled ensemble forecast system of ECMWF.

  4. Modelling turbulent vertical mixing sensitivity using a 1-D version of NEMO

    Science.gov (United States)

    Reffray, G.; Bourdalle-Badie, R.; Calone, C.

    2015-01-01

    Through two numerical experiments, a 1-D vertical model called NEMO1D was used to investigate physical and numerical turbulent-mixing behaviour. The results show that all the turbulent closures tested (k+l from Blanke and Delecluse, 1993, and two equation models: generic length scale closures from Umlauf and Burchard, 2003) are able to correctly reproduce the classical test of Kato and Phillips (1969) under favourable numerical conditions while some solutions may diverge depending on the degradation of the spatial and time discretization. The performances of turbulence models were then compared with data measured over a 1-year period (mid-2010 to mid-2011) at the PAPA station, located in the North Pacific Ocean. The modelled temperature and salinity were in good agreement with the observations, with a maximum temperature error between -2 and 2 °C during the stratified period (June to October). However, the results also depend on the numerical conditions. The vertical RMSE varied, for different turbulent closures, from 0.1 to 0.3 °C during the stratified period and from 0.03 to 0.15 °C during the homogeneous period. This 1-D configuration at the PAPA station (called PAPA1D) is now available in NEMO as a reference configuration including the input files and atmospheric forcing set described in this paper. Thus, all the results described can be recovered by downloading and launching PAPA1D. The configuration is described on the NEMO site (PAPA">http://www.nemo-ocean.eu/Using-NEMO/Configurations/C1D_PAPA). This package is a good starting point for further investigation of vertical processes.

  5. Development of high performance and very low radioactivity scintillation counters for the SuperNEMO calorimeter

    International Nuclear Information System (INIS)

    Chauveau, E.

    2010-11-01

    SuperNEMO is a next generation double beta decay experiment which will extend the successful 'tracko-calo' technique employed in NEMO 3. The main characteristic of this type of detector is to identify not only double beta decays, but also to measure its own background components. The project aims to reach a sensitivity up to 10 26 years on the half-life of 82 Se. One of the main challenge of the Research and Development is to achieve an unprecedented energy resolution for the electron calorimeter, better than 8 % FWHM at 1 MeV. This thesis contributes to improve scintillators and photomultipliers performances and reduce their radioactivity, including in particular the development of a new photomultiplier in collaboration with Photonis. (author)

  6. Probing new physics models of neutrinoless double beta decay with SuperNEMO

    Energy Technology Data Exchange (ETDEWEB)

    Arnold, R. [CNRS/IN2P3, IPHC, Universite de Strasbourg, Strasbourg (France); Augier, C.; Bongrand, M.; Garrido, X.; Jullian, S.; Sarazin, X.; Simard, L. [CNRS/IN2P3, LAL, Universite Paris-Sud 11, Orsay (France); Baker, J.; Caffrey, A.J.; Horkley, J.J.; Riddle, C.L. [INL, Idaho Falls, ID (United States); Barabash, A.S.; Konovalov, S.I.; Umatov, V.I.; Vanyushin, I.A. [Institute of Theoretical and Experimental Physics, Moscow (Russian Federation); Basharina-Freshville, A.; Evans, J.J.; Flack, R.; Holin, A.; Kauer, M.; Richards, B.; Saakyan, R.; Thomas, J.; Vasiliev, V.; Waters, D. [University College London, London (United Kingdom); Brudanin, V.; Egorov, V.; Kochetov, O.; Nemchenok, I.; Timkin, V.; Tretyak, V.; Vasiliev, R. [Joint Institute for Nuclear Research, Dubna (Russian Federation); Cebrian, S.; Dafni, T.; Irastorza, I.G.; Gomez, H.; Iguaz, F.J.; Luzon, G.; Rodriguez, A. [University of Zaragoza, Zaragoza (Spain); Chapon, A.; Durand, D.; Guillon, B.; Mauger, F. [Universite de Caen, LPC Caen, ENSICAEN, Caen (France); Chauveau, E.; Hubert, P.; Hugon, C.; Lutter, G.; Marquet, C.; Nachab, A.; Nguyen, C.H.; Perrot, F.; Piquemal, F.; Ricol, J.S. [UMR 5797, Universite de Bordeaux, Centre d' Etudes Nucleaires de Bordeaux Gradignan, Gradignan (France); UMR 5797, CNRS/IN2P3, Centre d' Etudes Nucleaires de Bordeaux Gradignan, Gradignan (France); Deppisch, F.F.; Jackson, C.M.; Nasteva, I.; Soeldner-Rembold, S. [Univ. of Manchester (United Kingdom); Diaz, J.; Monrabal, F.; Serra, L.; Yahlali, N. [CSIC - Univ. de Valencia, IFIC (Spain); Fushima, K.I. [Tokushima Univ., Tokushima (Japan); Holy, K.; Povinec, P.P.; Simkovic, F. [Comenius Univ., FMFI, Bratislava (Slovakia); Ishihara, N. [KEK, Tsukuba, Ibaraki (Japan); Kovalenko, V. [CNRS/IN2P3, IPHC, Univ. de Strasbourg (France); Joint Inst. for Nuclear Research, Dubna (Russian Federation); Lamhamdi, T. [USMBA, Fes (Morocco); Lang, K.; Pahlka, R.B. [Univ. of Texas, Austin, TX (United States)] (and others)

    2010-12-15

    The possibility to probe new physics scenarios of light Majorana neutrino exchange and right-handed currents at the planned next generation neutrinoless double {beta} decay experiment SuperNEMO is discussed. Its ability to study different isotopes and track the outgoing electrons provides the means to discriminate different underlying mechanisms for the neutrinoless double {beta} decay by measuring the decay half-life and the electron angular and energy distributions. (orig.)

  7. Cellular automaton and elastic net for event reconstruction in the NEMO-2 experiment

    International Nuclear Information System (INIS)

    Kisel, I.; Kovalenko, V.; Laplanche, F.

    1997-01-01

    A cellular automaton for track searching combined with an elastic net for charged particle trajectory fitting is presented. The advantages of the methods are: the simplicity of the algorithms, the fast and stable convergency to real tracks, and a good reconstruction efficiency. The combination of techniques have been used with success for event reconstruction on the data of the NEMO-2 double-beta (ββ) decay experiments. (orig.)

  8. NEMO-SN-1 the first 'real-time' seafloor observatory of ESONET

    International Nuclear Information System (INIS)

    Favali, Paolo; Beranzoli, Laura; D'Anna, Giuseppe; Gasparoni, Francesco; Gerber, Hans W.

    2006-01-01

    The fruitful collaboration between Italian Research Institutions, particularly Istituto Nazionale di Fisica Nucleare (INFN) and Istituto Nazionale di Geofisica e Vulcanologia (INGV) together with Marine Engineering Companies, led to the development of NEMO-SN-1, the first European cabled seafloor multiparameter observatory. This observatory, deployed at 2060 m w.d. about 12 miles off-shore the Eastern coasts of Sicily (Southern Italy), is in real-time acquisition since January 2005 and addressed to different set of measurements: geophysical and oceanographic. In particular the SN-1 seismological data are integrated in the INGV land-based national seismic network, and they arrive in real-time to the Operative Centre in Rome. In the European Commission (EC) European Seafloor Observatory NETwork (ESONET) project, in connection to the Global Monitoring for Environment and Security (GMES) action plan, the NEMO-SN-1 site has been proposed as an European key area, both for its intrinsic importance for geo-hazards and for the availability of infrastructure as a stepwise development in GMES program. Presently, NEMO-SN-1 is the only ESONET site operative. The paper gives a description of SN-1 observatory with examples of data

  9. A Spectrum Handoff Scheme for Optimal Network Selection in NEMO Based Cognitive Radio Vehicular Networks

    Directory of Open Access Journals (Sweden)

    Krishan Kumar

    2017-01-01

    Full Text Available When a mobile network changes its point of attachments in Cognitive Radio (CR vehicular networks, the Mobile Router (MR requires spectrum handoff. Network Mobility (NEMO in CR vehicular networks is concerned with the management of this movement. In future NEMO based CR vehicular networks deployment, multiple radio access networks may coexist in the overlapping areas having different characteristics in terms of multiple attributes. The CR vehicular node may have the capability to make call for two or more types of nonsafety services such as voice, video, and best effort simultaneously. Hence, it becomes difficult for MR to select optimal network for the spectrum handoff. This can be done by performing spectrum handoff using Multiple Attributes Decision Making (MADM methods which is the objective of the paper. The MADM methods such as grey relational analysis and cost based methods are used. The application of MADM methods provides wider and optimum choice among the available networks with quality of service. Numerical results reveal that the proposed scheme is effective for spectrum handoff decision for optimal network selection with reduced complexity in NEMO based CR vehicular networks.

  10. Development of an optical simulation for the SuperNEMO calorimeter

    Science.gov (United States)

    Huber, Arnaud; SuperNEMO Collaboration

    2017-09-01

    The SuperNEMO double beta decay project is a modular tracker-calorimeter based experiment. The aim of this project is to reach a sensitivity of the order of 1026 years concerning the neutrinoless double beta decay half-life, corresponding to a Majorana neutrino mass of 50-100 meV. The main calorimeter of the SuperNEMO demonstrator is based on 520 Optical Modules made of large volume plastic scintillators (10L) coupled with large area photomultipliers (Hamamatsu R5912-MOD and R6594). The design of the calorimeter is optimized for the double beta decay detection and allows gamma tagging for background rejection. In large volumes of scintillators, a similar deposited energy by electrons or photons will give different visible energy and signal shapes due to different interactions inside the scintillator. The aim of the optical simulation, developed for SuperNEMO, is to model the Optical Module response on the energy and time performances, regarding the particle type.

  11. NEMO-SN1 observatory developments in view of the European Research Infrastructures EMSO and KM3NET

    Energy Technology Data Exchange (ETDEWEB)

    Favali, Paolo, E-mail: emsopp@ingv.i [Istituto Nazionale di Geofisica e Vulcanologia (INGV), Sect. Roma 2, Via di Vigna Murata 605, 00143 Roma (Italy); Beranzoli, Laura [Istituto Nazionale di Geofisica e Vulcanologia (INGV), Sect. Roma 2, Via di Vigna Murata 605, 00143 Roma (Italy); Italiano, Francesco [Istituto Nazionale di Geofisica e Vulcanologia (INGV), Sect. Palermo, Via Ugo La Malfa 153, 90146 Palermo (Italy); Migneco, Emilio; Musumeci, Mario; Papaleo, Riccardo [Istituto Nazionale di Fisica Nucleare (INFN), Laboratori Nazionali del Sud, Via di S. Sofia 62, 95125 Catania (Italy)

    2011-01-21

    NEMO-SN1 (Western Ionian Sea off Eastern Sicily), the first real-time multiparameter observatory operating in Europe since 2005, is one of the nodes of the upcoming European ESFRI large-scale research infrastructure EMSO (European Multidisciplinary Seafloor Observatory), a network of seafloor observatories placed at marine sites on the European Continental Margin. NEMO-SN1 constitutes also an important test-site for the study of prototypes of Kilometre Cube Neutrino Telescope (KM3NeT), another European ESFRI large-scale research infrastructure. Italian resources have been devoted to the development of NEMO-SN1 facilities and logistics, as with the PEGASO project, while the EC project ESONET-NoE is funding a demonstration mission and a technological test. EMSO and KM3NeT are presently in the Preparatory Phase as projects funded under the EC-FP7.

  12. Hypohidrotic ectodermal dysplasia and immunodeficiency with coincident NEMO and EDA Mutations

    Directory of Open Access Journals (Sweden)

    Michael D. Keller

    2011-11-01

    Full Text Available Ectodermal dysplasias (ED are uncommon genetic disorders resulting in abnormalities in ectodermally-derived structures. Though many ED-associated genes have been described, the NF-κB Essential Modulator (NEMO encoded by the IKBKG gene is unique in that mutations also result in severe humoral and cellular immunologic defects. We describe three unrelated kindreds with defects in both EDA and IKBKG resulting from an X-chromosome crossover. This demonstrates the importance of thorough immunologic consideration of patients with ED even when an EDA etiology is confirmed, and raises the possibility of a specific phenotype arising from coincident mutations in EDA and IKBKB.

  13. Radon emanation chamber: High sensitivity measurements for the SuperNEMO experiment

    Energy Technology Data Exchange (ETDEWEB)

    Soulé, B. [Université Bordeaux 1, Centre d' Etudes Nucléaires de Bordeaux Gradignan, UMR 5797, Chemin du Solarium, Le Haut-Vigneau, BP120, F-33175 Gradignan (France); Collaboration: SuperNEMO Collaboration; and others

    2013-08-08

    Radon is a well-known source of background in ββ0ν experiments due to the high Q{sub β} value of one of its daughter nucleus, {sup 214}Bi. The SuperNEMO collaboration requires a maximum radon contamination of 0.1 mBq/m{sup 3} inside its next-generation double beta decay detector. To reach such a low activity, a drastic screening process has been set for the selection of the detector's materials. In addition to a good radiopurity, a low emanation rate is required. To test this parameter, a Radon Emanation Setup is running at CENBG. It consists in a large emanation chamber connected to an electrostatic detector. By measuring large samples and having a low background level, this setup reaches a sensitivity of a few μ Bq. m{sup −2}. d{sup −1} and is able to qualify materials used in the construction of the SuperNEMO detector.

  14. Novel hypomorphic mutation in IKBKG impairs NEMO-ubiquitylation causing ectodermal dysplasia, immunodeficiency, incontinentia pigmenti, and immune thrombocytopenic purpura.

    Science.gov (United States)

    Ramírez-Alejo, Noé; Alcántara-Montiel, Julio C; Yamazaki-Nakashimada, Marco; Duran-McKinster, Carola; Valenzuela-León, Paola; Rivas-Larrauri, Francisco; Cedillo-Barrón, Leticia; Hernández-Rivas, Rosaura; Santos-Argumedo, Leopoldo

    2015-10-01

    NF-κB essential modulator (NEMO) is a component of the IKK complex, which participates in the activation of the NF-κB pathway. Hypomorphic mutations in the IKBKG gene result in different forms of anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) in males without affecting carrier females. Here, we describe a hypomorphic and missense mutation, designated c.916G>A (p.D306N), which affects our patient, his mother, and his sister. This mutation did not affect NEMO expression; however, an immunoprecipitation assay revealed reduced ubiquitylation upon CD40-stimulation in the patient's cells. Functional studies have demonstrated reduced phosphorylation and degradation of IκBα, affecting NF-κB recruitment into the nucleus. The patient presented with clinical features of ectodermal dysplasia, immunodeficiency, and immune thrombocytopenic purpura, the latter of which has not been previously reported in a patient with NEMO deficiency. His mother and sister displayed incontinentia pigmenti indicating that, in addition to amorphic mutations, hypomorphic mutations in NEMO can affect females. Copyright © 2015 Elsevier Inc. All rights reserved.

  15. Study of tracking detector of NEMO3 experiment - simulation of the measurement of the ultra low {sup 208}Tl radioactivity in the source foils used as neutrinoless double beta decay emitters in NEMO3 experiment; Etude du detecteur de traces de l'experience NEMO3. Simulation de la mesure de l'ultra-faible radioactivite en {sup 208}Tl des sources de l'experience NEMO3 candidates a la double desintegration {beta} sans emission de neutrino

    Energy Technology Data Exchange (ETDEWEB)

    Errahmane, K

    2001-04-01

    The purpose of NEMO3 experiment is the research of the neutrinoless double beta decay. This low energy process can sign the massive and Majorana nature of neutrino. This experiment, with a very low radioactive background and containing 10 kg of enriched isotopes, studies mainly {sup 100}Mo. Installed at the Frejus underground laboratory, NEMO3 is a cylindrical detector, which consists in very thin central source foils, in a tracking detector made up of vertical drift cells operating in Geiger mode, in a calorimeter and in a suitable shielding. This thesis is divided in two different parts. The first part is a full study of the features of the tracking detector. With a prototype composed of 9 drift cells, we characterised the longitudinal and transverse reconstruction of position of the ionisation created by a LASER. With the first 3 modules under operation, we used radioactive external neutron sources to measure the transverse resolution of ionisation position in a drift cell for high energy electrons. To study the vertex reconstruction on the source foil, sources of {sup 207}Bi, which produced conversion electrons, were used inside the 3 modules. The second part of this thesis, we show, with simulations, that we can measure, with NEMO3 detector itself, the ultra low level of contamination in {sup 208}Tl of the source foil, which comes from the natural radioactive chain of thorium. Using electron-photons channels, we can obtain the {sup 208}Tl activity in the sources. With an analysis on the energy and on the time of flight of particles, NEMO3 is able to reach a sensitivity of 20{mu}Bq/kg after only 2 months of measurement. This sensitivity is the maximum {sup 208}Tl activity, which we accepted for the sources in the NEMO3 proposal. (author)

  16. Design and assembly of the optical modules for phase-2 of the NEMO project

    Energy Technology Data Exchange (ETDEWEB)

    Leonora, E., E-mail: emanuele.leonora@ct.infn.it; Aiello, S.

    2013-10-11

    The NEMO collaboration team has undertaken a Phase-2 project, which aims at the realization and installation of a new infrastructure at the Capo Passero (Italy) deep-sea site at a depth of 3500 m. With this objective in mind, a fully equipped tower with 8-storey hosting two optical modules at each end is under construction. Following a well established procedure, 32 optical modules have been assembled. The optical module consists of a large area photomultiplier tube enclosed in a pressure resistant glass sphere with a diameter of 13 in. The photomultiplier is a R7081 type, produced by Hamamatsu, with a photocathode area with a diameter of 10 in. and 10 dynodes. Mechanical and optical contacts between the front of the photomultiplier tube and the glass surface are ensured by an optical bi-component silicone gel. A mu-metal cage is used to shield the photomultiplier against the influence of the Earth's magnetic field.

  17. Jules Verne's Captain Nemo and French Revolutionary Gustave Flourens:A Hidden Character Model?

    Directory of Open Access Journals (Sweden)

    Leonidas Kallivretakis

    2005-01-01

    Full Text Available This article treats the recent assumption made by Vernian specialist William Butcher that Jules Verne's most famous character, Captain Nemo, is based on the French revolutionary intellectual Gustave Flourens (1838-1871, son of the eminent physiologist J. P. M. Flourens. Gustave Flourens fought in the Cretan insurrection of 1866-1868, later participated in the republican opposition against Napoleon III's imperial regime, eventually became a friend of Karl Marx and was finally killed as a general of the Paris Commune. By comparing step-by-step Verne's inspiration and writing procedures with Flourens' unfolding activities and fame, it is concluded that there is little basis for such an assumption. The article includes also a brief account of the Cretan question in the nineteenth century and of the deep discord between Marx's and Flourens' respective analyses of the Eastern Question.

  18. NEMO on the shelf: assessment of the Iberia–Biscay–Ireland configuration

    Directory of Open Access Journals (Sweden)

    C. Maraldi

    2013-08-01

    Full Text Available This work describes the design and validation of a high-resolution (1/36° ocean forecasting model over the "Iberian–Biscay–Irish" (IBI area. The system has been set-up using the NEMO model (Nucleus for European Modelling of the Ocean. New developments have been incorporated in NEMO to make it suitable to open- as well as coastal-ocean modelling. In this paper, we pursue three main objectives: (1 to give an overview of the model configuration used for the simulations; (2 to give a broad-brush account of one particular aspect of this work, namely consistency verification; this type of validation is conducted upstream of the implementation of the system before it is used for production and routinely validated; it is meant to guide model development in identifying gross deficiencies in the modelling of several key physical processes; and (3 to show that such a regional modelling system has potential as a complement to patchy observations (an integrated approach to give information on non-observed physical quantities and to provide links between observations by identifying broader-scale patterns and processes. We concentrate on the year 2008. We first provide domain-wide consistency verification results in terms of barotropic tides, transports, sea surface temperature and stratification. We then focus on two dynamical subregions: the Celtic shelves and the Bay of Biscay slope and deep regions. The model–data consistency is checked for variables and processes such as tidal currents, tidal fronts, internal tides and residual elevation. We also examine the representation in the model of a seasonal pattern of the Bay of Biscay circulation: the warm extension of the Iberian Poleward Current along the northern Spanish coast (Navidad event in the winter of 2007–2008.

  19. Sea-ice evaluation of NEMO-Nordic 1.0: a NEMO-LIM3.6-based ocean-sea-ice model setup for the North Sea and Baltic Sea

    Science.gov (United States)

    Pemberton, Per; Löptien, Ulrike; Hordoir, Robinson; Höglund, Anders; Schimanke, Semjon; Axell, Lars; Haapala, Jari

    2017-08-01

    The Baltic Sea is a seasonally ice-covered marginal sea in northern Europe with intense wintertime ship traffic and a sensitive ecosystem. Understanding and modeling the evolution of the sea-ice pack is important for climate effect studies and forecasting purposes. Here we present and evaluate the sea-ice component of a new NEMO-LIM3.6-based ocean-sea-ice setup for the North Sea and Baltic Sea region (NEMO-Nordic). The setup includes a new depth-based fast-ice parametrization for the Baltic Sea. The evaluation focuses on long-term statistics, from a 45-year long hindcast, although short-term daily performance is also briefly evaluated. We show that NEMO-Nordic is well suited for simulating the mean sea-ice extent, concentration, and thickness as compared to the best available observational data set. The variability of the annual maximum Baltic Sea ice extent is well in line with the observations, but the 1961-2006 trend is underestimated. Capturing the correct ice thickness distribution is more challenging. Based on the simulated ice thickness distribution we estimate the undeformed and deformed ice thickness and concentration in the Baltic Sea, which compares reasonably well with observations.

  20. Oceanographic conditions in the NEMO region during the KM3NeT project (April 2006-May 2009)

    International Nuclear Information System (INIS)

    Sparnocchia, Stefania; Pietro Gasparini, Gian; Schroeder, Katrin; Borghini, Mireno

    2011-01-01

    An intense observational activity was conducted in the NEMO region, western Ionian Sea, 40 nm south-east of Capo Passero (Sicily), in the framework of the KM3NeT project. Several oceanographic cruises were performed from 2006 to 2009 and current measurements carried out. The new data describe the present status of the deep layer and its evolution after the occurrence of a notable change that affected the Eastern Mediterranean water masses and circulation during the 1990's. In particular, they evidence the presence of a newly formed water mass in the abyssal layer of the Ionian Sea, coming likely from the Adriatic. Deep currents in the region are quite energetic, as already known, and highly variable both spatially and in strength. They are organized in a cyclonic circuit, with a prevalent north-west direction corresponding to the NEMO site.

  1. Long term monitoring of the optical background in the Capo Passero deep-sea site with the NEMO tower prototype

    International Nuclear Information System (INIS)

    Adrian-Martinez, S.; Ardid, M.; Llorens Alvarez, C.D.; Saldana, M.; Aiello, S.; Giordano, V.; Leonora, E.; Longhitano, F.; Randazzo, N.; Sipala, V.; Ventura, C.; Ameli, F.; Biagioni, A.; De Bonis, G.; Fermani, P.; Lonardo, A.; Nicolau, C.A.; Simeone, F.; Vicini, P.; Anghinolfi, M.; Hugon, C.; Musico, P.; Orzelli, A.; Sanguineti, M.; Barbarino, G.; Barbato, F.C.T.; De Rosa, G.; Di Capua, F.; Garufi, F.; Vivolo, D.; Barbarito, E.; Beverini, N.; Calamai, M.; Maccioni, E.; Marinelli, A.; Terreni, G.; Biagi, S.; Cacopardo, G.; Cali, C.; Caruso, F.; Cocimano, R.; Coniglione, R.; Costa, M.; Cuttone, G.; D'Amato, C.; De Luca, V.; Distefano, C.; Gmerk, A.; Grasso, R.; Imbesi, M.; Kulikovskiy, V.; Larosa, G.; Lattuada, D.; Leismueller, K.P.; Litrico, P.; Migneco, E.; Miraglia, A.; Musumeci, M.; Orlando, A.; Papaleo, R.; Pulvirenti, S.; Riccobene, G.; Rovelli, A.; Sapienza, P.; Sciacca, V.; Speziale, F.; Spitaleri, A.; Trovato, A.; Viola, S.; Bouhadef, B.; Flaminio, V.; Raffaelli, F.; Bozza, C.; Grella, G.; Stellacci, S.M.; Calvo, D.; Real, D.; Capone, A.; Masullo, R.; Perrina, C.; Ceres, A.; Circella, M.; Mongelli, M.; Sgura, I.; Chiarusi, T.; D'Amico, A.; Deniskina, N.; Migliozzi, P.; Mollo, C.M.; Enzenhoefer, A.; Lahmann, R.; Ferrara, G.; Fusco, L.A.; Margiotta, A.; Pellegrino, C.; Spurio, M.; Lo Presti, D.; Pugliatti, C.; Martini, A.; Trasatti, L.; Morganti, M.; Pellegriti, M.G.; Piattelli, P.; Taiuti, M.

    2016-01-01

    The NEMO Phase-2 tower is the first detector which was operated underwater for more than 1 year at the ''record'' depth of 3500 m. It was designed and built within the framework of the NEMO (NEutrino Mediterranean Observatory) project. The 380 m high tower was successfully installed in March 2013 80 km offshore Capo Passero (Italy). This is the first prototype operated on the site where the Italian node of the KM3NeT neutrino telescope will be built. The installation and operation of the NEMO Phase-2 tower has proven the functionality of the infrastructure and the operability at 3500 m depth. A more than 1 year long monitoring of the deep water characteristics of the site has been also provided. In this paper the infrastructure and the tower structure and instrumentation are described. The results of long term optical background measurements are presented. The rates show stable and low baseline values, compatible with the contribution of 40 K light emission, with a small percentage of light bursts due to bioluminescence. All these features confirm the stability and good optical properties of the site. (orig.)

  2. Long term monitoring of the optical background in the Capo Passero deep-sea site with the NEMO tower prototype

    Energy Technology Data Exchange (ETDEWEB)

    Adrian-Martinez, S.; Ardid, M.; Llorens Alvarez, C.D.; Saldana, M. [Universitat Politecnica de Valencia, Instituto de Investigacion para la Gestion Integrada de las Zonas Costeras, Gandia (Spain); Aiello, S.; Giordano, V.; Leonora, E.; Longhitano, F.; Randazzo, N.; Sipala, V.; Ventura, C. [INFN Sezione Catania, Catania (Italy); Ameli, F.; Biagioni, A.; De Bonis, G.; Fermani, P.; Lonardo, A.; Nicolau, C.A.; Simeone, F.; Vicini, P. [INFN Sezione Roma, Rome (Italy); Anghinolfi, M.; Hugon, C.; Musico, P.; Orzelli, A.; Sanguineti, M. [INFN Sezione Genova, Genoa (Italy); Barbarino, G.; Barbato, F.C.T.; De Rosa, G.; Di Capua, F.; Garufi, F.; Vivolo, D. [INFN Sezione Napoli, Naples (Italy); Dipartimento di Scienze Fisiche Universita di Napoli, Naples (Italy); Barbarito, E. [INFN Sezione Bari, Bari (Italy); Dipartimento Interateneo di Fisica Universita di Bari, Bari (Italy); Beverini, N.; Calamai, M.; Maccioni, E.; Marinelli, A.; Terreni, G. [INFN Sezione Pisa, Polo Fibonacci, Pisa (Italy); Dipartimento di Fisica Universita di Pisa, Polo Fibonacci, Pisa (Italy); Biagi, S.; Cacopardo, G.; Cali, C.; Caruso, F.; Cocimano, R.; Coniglione, R.; Costa, M.; Cuttone, G.; D' Amato, C.; De Luca, V.; Distefano, C.; Gmerk, A.; Grasso, R.; Imbesi, M.; Kulikovskiy, V.; Larosa, G.; Lattuada, D.; Leismueller, K.P.; Litrico, P.; Migneco, E.; Miraglia, A.; Musumeci, M.; Orlando, A.; Papaleo, R.; Pulvirenti, S.; Riccobene, G.; Rovelli, A.; Sapienza, P.; Sciacca, V.; Speziale, F.; Spitaleri, A.; Trovato, A.; Viola, S. [INFN Laboratori Nazionali del Sud, Catania (Italy); Bouhadef, B.; Flaminio, V.; Raffaelli, F. [INFN Sezione Pisa, Polo Fibonacci, Pisa (Italy); Bozza, C.; Grella, G.; Stellacci, S.M. [INFN Gruppo Collegato di Salerno, Fisciano (Italy); Dipartimento di Fisica Universita di Salerno, Fisciano (Italy); Calvo, D.; Real, D. [CSIC-Universitat de Valencia, IFIC-Instituto de Fisica Corpuscular, Valencia (Spain); Capone, A.; Masullo, R.; Perrina, C. [INFN Sezione Roma, Rome (Italy); Dipartimento di Fisica Universita ' ' Sapienza' ' , Rome (Italy); Ceres, A.; Circella, M.; Mongelli, M.; Sgura, I. [INFN Sezione Bari, Bari (Italy); Chiarusi, T. [INFN Sezione Bologna, Bologna (Italy); D' Amico, A. [INFN Laboratori Nazionali del Sud, Catania (Italy); Nikhef, Science Park, Amsterdam (Netherlands); Deniskina, N.; Migliozzi, P.; Mollo, C.M. [INFN Sezione Napoli, Naples (Italy); Enzenhoefer, A.; Lahmann, R. [Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Erlangen Centre for Astroparticle Physics, Erlangen (Germany); Ferrara, G. [INFN Laboratori Nazionali del Sud, Catania (Italy); Dipartimento di Fisica e Astronomia Universita di Catania, Catania (Italy); Fusco, L.A.; Margiotta, A.; Pellegrino, C.; Spurio, M. [INFN Sezione Bologna, Bologna (Italy); Dipartimento di Fisica ed Astronomia Universita di Bologna, Bologna (Italy); Lo Presti, D.; Pugliatti, C. [INFN Sezione Catania, Catania (Italy); Dipartimento di Fisica e Astronomia Universita di Catania, Catania (Italy); Martini, A.; Trasatti, L. [INFN Laboratori Nazionali di Frascati, Frascati (Italy); Morganti, M. [INFN Sezione Pisa, Polo Fibonacci, Pisa (Italy); Accademia Navale di Livorno, Livorno (Italy); Pellegriti, M.G. [INFN Laboratori Nazionali del Sud, Catania (IT); Piattelli, P. [INFN Laboratori Nazionali del Sud, Catania (IT); Taiuti, M. [INFN Sezione Genova, Genoa (IT); Dipartimento di Fisica Universita di Genova, Genoa (IT)

    2016-02-15

    The NEMO Phase-2 tower is the first detector which was operated underwater for more than 1 year at the ''record'' depth of 3500 m. It was designed and built within the framework of the NEMO (NEutrino Mediterranean Observatory) project. The 380 m high tower was successfully installed in March 2013 80 km offshore Capo Passero (Italy). This is the first prototype operated on the site where the Italian node of the KM3NeT neutrino telescope will be built. The installation and operation of the NEMO Phase-2 tower has proven the functionality of the infrastructure and the operability at 3500 m depth. A more than 1 year long monitoring of the deep water characteristics of the site has been also provided. In this paper the infrastructure and the tower structure and instrumentation are described. The results of long term optical background measurements are presented. The rates show stable and low baseline values, compatible with the contribution of {sup 40}K light emission, with a small percentage of light bursts due to bioluminescence. All these features confirm the stability and good optical properties of the site. (orig.)

  3. Evaluation of the coupled COSMO-CLM+NEMO-Nordic model with focus on North and Baltic seas

    Science.gov (United States)

    Lenhardt, J.; Pham, T. V.; Früh, B.; Brauch, J.

    2017-12-01

    The region east of the Baltic Sea has been identified as a hot-spot of climate change by Giorgi, 2006, on the base of temperature and precipitation variability. For this purpose, the atmosphere model COSMO-CLM has been coupled to the ocean model NEMO, including the sea ice model LIM3, via the OASIS3-MCT coupler (Pham et al., 2014). The coupler interpolates heat, fresh water, momentum fluxes, sea level pressure and the fraction of sea ice at the interface in space and time. Our aim is to find an optimal configuration of the already existing coupled regional atmospheric-ocean model COSMO-CLM+NEMO-Nordic. So far results for the North- and Baltic seas show that the coupled run has large biases compared with the E-OBS reference data. Therefore, additional simulation evaluations are planned by the use of independent satellite observation data (e.g. Copernicus, EURO4M). We have performed a series of runs with the coupled COSMO-CLM+NEMO-Nordic model to find out about differences of model outputs due to different coupling time steps. First analyses of COSMO-CLM 2m temperatures let presume that different coupling time steps have an impact on the results of the coupled model run. Additional tests over a longer period of time are conducted to understand whether the signal-to-noise ratio could influence the bias. The results will be presented in our poster.

  4. Development and Pre-Operational Validation of NEMO Based Eddy Ressolving Regional Configuration for Gulf of Finland

    Science.gov (United States)

    Sofina, Ekaterina; Vankevich, Roman; Tatiana, Eremina

    2014-05-01

    At the present day RSHU the Operational Oceanographic System for the Gulf of Finland (GULFOOS) is in a trial operation. For the future development of the operational system, the quality of which also strongly depends on the hydrothermodynamic model spatial resolution. The new model configuration has been implemented, based on the international project NEMO (Nucleus for European Modelling of the Ocean). Based on NEMO toolbox a new eddy permitting z-coordinated configuration realized with horizontal resolution 30x15'' (~500 m) and 1 m vertical step. Chosen horizontal resolution enough to resolve typical submesoscale eddies in this basin where the internal Rossby radius is usually 2-4 km [1]. Verification performed with use all available measurements including vessel, ferry boxes, autonomous profilers, satellite SST. It was shown that submesoscale eddies and filaments generated by baroclinic instability of fronts in upper layers of the Gulf can change vertical stratification and deepening of the mixed layer. Increase in the model resolution leads to a clear improvement of the representation of the key hydro-physical fields: filaments propagation, local eddies. Obtained results confirm that model adequately reproduce general circulation and seasonal evolution of vertical water structure. It is shown that NEMO model initially designed for a global ocean can be used in regional operational application in case of highly stratified shallow basin with complex bathymetry. Computation efficiency of the system including 3DVar assimilation was enough for 24x7 operational task on 12 nodes of Intel based cluster. Proposed regional modeling system has potential to give information on non-observed physical quantities and to provide links between observations by identifying small-scale patterns and processes. References 1. Alenius P., Nekrasov A., Myrberg, K. The baroclinic Rossby-radius in the Gulf of Finland. Continental Shelf Research, 2003, 23, 563-573.

  5. Explicit representation and parametrised impacts of under ice shelf seas in the z∗ coordinate ocean model NEMO 3.6

    Directory of Open Access Journals (Sweden)

    P. Mathiot

    2017-07-01

    Full Text Available Ice-shelf–ocean interactions are a major source of freshwater on the Antarctic continental shelf and have a strong impact on ocean properties, ocean circulation and sea ice. However, climate models based on the ocean–sea ice model NEMO (Nucleus for European Modelling of the Ocean currently do not include these interactions in any detail. The capability of explicitly simulating the circulation beneath ice shelves is introduced in the non-linear free surface model NEMO. Its implementation into the NEMO framework and its assessment in an idealised and realistic circum-Antarctic configuration is described in this study. Compared with the current prescription of ice shelf melting (i.e. at the surface, inclusion of open sub-ice-shelf cavities leads to a decrease in sea ice thickness along the coast, a weakening of the ocean stratification on the shelf, a decrease in salinity of high-salinity shelf water on the Ross and Weddell sea shelves and an increase in the strength of the gyres that circulate within the over-deepened basins on the West Antarctic continental shelf. Mimicking the overturning circulation under the ice shelves by introducing a prescribed meltwater flux over the depth range of the ice shelf base, rather than at the surface, is also assessed. It yields similar improvements in the simulated ocean properties and circulation over the Antarctic continental shelf to those from the explicit ice shelf cavity representation. With the ice shelf cavities opened, the widely used three equation ice shelf melting formulation, which enables an interactive computation of melting, is tested. Comparison with observational estimates of ice shelf melting indicates realistic results for most ice shelves. However, melting rates for the Amery, Getz and George VI ice shelves are considerably overestimated.

  6. Failure of the Nemo trial: bumetanide is a promising agent to treat many brain disorders but not newborn seizures

    Directory of Open Access Journals (Sweden)

    Yehezkel eBen-Ari

    2016-04-01

    Full Text Available The diuretic bumetanide failed to treat acute seizures due to hypoxic ischemic encephalopathy (HIE in newborn babies and was associated with hearing loss (NEMO trial; 1. On the other hand, clinical and experimental observations suggest that the diuretic might provide novel therapy for many brain disorders including autistic spectrum disorder, schizophrenia, Rett syndrome and Parkinson disease. Here, we discuss the differences between the pathophysiology of severe recurrent seizures in the neonates and neurological and psychiatric disorders stressing the uniqueness of severe seizures in newborn in comparison to other disorders.

  7. South Atlantic meridional transports from NEMO-based simulations and reanalyses

    Science.gov (United States)

    Mignac, Davi; Ferreira, David; Haines, Keith

    2018-02-01

    The meridional heat transport (MHT) of the South Atlantic plays a key role in the global heat budget: it is the only equatorward basin-scale ocean heat transport and it sets the northward direction of the global cross-equatorial transport. Its strength and variability, however, are not well known. The South Atlantic transports are evaluated for four state-of-the-art global ocean reanalyses (ORAs) and two free-running models (FRMs) in the period 1997-2010. All products employ the Nucleus for European Modelling of the Oceans (NEMO) model, and the ORAs share very similar configurations. Very few previous works have looked at ocean circulation patterns in reanalysis products, but here we show that the ORA basin interior transports are consistently improved by the assimilated in situ and satellite observations relative to the FRMs, especially in the Argo period. The ORAs also exhibit systematically higher meridional transports than the FRMs, which is in closer agreement with observational estimates at 35 and 11° S. However, the data assimilation impact on the meridional transports still greatly varies among the ORAs, leading to differences up to ˜ 8 Sv and 0.4 PW in the South Atlantic Meridional Overturning Circulation and the MHTs, respectively. We narrow this down to large inter-product discrepancies in the western boundary currents (WBCs) at both upper and deep levels explaining up to ˜ 85 % of the inter-product differences in MHT. We show that meridional velocity differences, rather than temperature differences, in the WBCs drive ˜ 83 % of this MHT spread. These findings show that the present ocean observation network and data assimilation schemes can be used to consistently constrain the South Atlantic interior circulation but not the overturning component, which is dominated by the narrow western boundary currents. This will likely limit the effectiveness of ORA products for climate or decadal prediction studies.

  8. Intestinal exposure to PCB 153 induces inflammation via the ATM/NEMO pathway.

    Science.gov (United States)

    Phillips, Matthew C; Dheer, Rishu; Santaolalla, Rebeca; Davies, Julie M; Burgueño, Juan; Lang, Jessica K; Toborek, Michal; Abreu, Maria T

    2018-01-15

    Polychlorinated biphenyls (PCBs) are persistent organic pollutants that adversely affect human health. PCBs bio-accumulate in organisms important for human consumption. PCBs accumulation in the body leads to activation of the transcription factor NF-κB, a major driver of inflammation. Despite dietary exposure being one of the main routes of exposure to PCBs, the gut has been widely ignored when studying the effects of PCBs. We investigated the effects of PCB 153 on the intestine and addressed whether PCB 153 affected intestinal permeability or inflammation and the mechanism by which this occurred. Mice were orally exposed to PCB 153 and gut permeability was assessed. Intestinal epithelial cells (IECs) were collected and evaluated for evidence of genotoxicity and inflammation. A human IEC line (SW480) was used to examine the direct effects of PCB 153 on epithelial function. NF-кB activation was measured using a reporter assay, DNA damage was assessed, and cytokine expression was ascertained with real-time PCR. Mice orally exposed to PCB 153 had an increase in intestinal permeability and inflammatory cytokine expression in their IECs; inhibition of NF-кB ameliorated both these effects. This inflammation was associated with genotoxic damage and NF-кB activation. Exposure of SW480 cells to PCB 153 led to similar effects as seen in vivo. We found that activation of the ATM/NEMO pathway by genotoxic stress was upstream of NF-kB activation. These results demonstrate that oral exposure to PCB 153 is genotoxic to IECs and induces downstream inflammation and barrier dysfunction in the intestinal epithelium. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. Finding NEMO (novel electromaterial muscle oscillator): a polypyrrole powered robotic fish with real-time wireless speed and directional control

    International Nuclear Information System (INIS)

    McGovern, Scott; Alici, Gursel; Spinks, Geoffrey; Truong, Van-Tan

    2009-01-01

    This paper presents the development of an autonomously powered and controlled robotic fish that incorporates an active flexural joint tail fin, activated through conducting polymer actuators based on polypyrrole (PPy). The novel electromaterial muscle oscillator (NEMO) tail fin assembly on the fish could be controlled wirelessly in real time by varying the frequency and duty cycle of the voltage signal supplied to the PPy bending-type actuators. Directional control was achieved by altering the duty cycle of the voltage input to the NEMO tail fin, which shifted the axis of oscillation and enabled turning of the robotic fish. At low speeds, the robotic fish had a turning circle as small as 15 cm (or 1.1 body lengths) in radius. The highest speed of the fish robot was estimated to be approximately 33 mm s −1 (or 0.25 body lengths s −1 ) and was achieved with a flapping frequency of 0.6–0.8 Hz which also corresponded with the most hydrodynamically efficient mode for tail fin operation. This speed is approximately ten times faster than those for any previously reported artificial muscle based device that also offers real-time speed and directional control. This study contributes to previously published studies on bio-inspired functional devices, demonstrating that electroactive polymer actuators can be real alternatives to conventional means of actuation such as electric motors

  10. Finding NEMO (novel electromaterial muscle oscillator): a polypyrrole powered robotic fish with real-time wireless speed and directional control

    Science.gov (United States)

    McGovern, Scott; Alici, Gursel; Truong, Van-Tan; Spinks, Geoffrey

    2009-09-01

    This paper presents the development of an autonomously powered and controlled robotic fish that incorporates an active flexural joint tail fin, activated through conducting polymer actuators based on polypyrrole (PPy). The novel electromaterial muscle oscillator (NEMO) tail fin assembly on the fish could be controlled wirelessly in real time by varying the frequency and duty cycle of the voltage signal supplied to the PPy bending-type actuators. Directional control was achieved by altering the duty cycle of the voltage input to the NEMO tail fin, which shifted the axis of oscillation and enabled turning of the robotic fish. At low speeds, the robotic fish had a turning circle as small as 15 cm (or 1.1 body lengths) in radius. The highest speed of the fish robot was estimated to be approximately 33 mm s-1 (or 0.25 body lengths s-1) and was achieved with a flapping frequency of 0.6-0.8 Hz which also corresponded with the most hydrodynamically efficient mode for tail fin operation. This speed is approximately ten times faster than those for any previously reported artificial muscle based device that also offers real-time speed and directional control. This study contributes to previously published studies on bio-inspired functional devices, demonstrating that electroactive polymer actuators can be real alternatives to conventional means of actuation such as electric motors.

  11. NBodyLab: A Testbed for Undergraduates Utilizing a Web Interface to NEMO and MD-GRAPE2 Hardware

    Science.gov (United States)

    Johnson, V. L.; Teuben, P. J.; Penprase, B. E.

    An N-body simulation testbed called NBodyLab was developed at Pomona College as a teaching tool for undergraduates. The testbed runs under Linux and provides a web interface to selected back-end NEMO modeling and analysis tools, and several integration methods which can optionally use an MD-GRAPE2 supercomputer card in the server to accelerate calculation of particle-particle forces. The testbed provides a framework for using and experimenting with the main components of N-body simulations: data models and transformations, numerical integration of the equations of motion, analysis and visualization products, and acceleration techniques (in this case, special purpose hardware). The testbed can be used by students with no knowledge of programming or Unix, freeing such students and their instructor to spend more time on scientific experimentation. The advanced student can extend the testbed software and/or more quickly transition to the use of more advanced Unix-based toolsets such as NEMO, Starlab and model builders such as GalactICS. Cosmology students at Pomona College used the testbed to study collisions of galaxies with different speeds, masses, densities, collision angles, angular momentum, etc., attempting to simulate, for example, the Tadpole Galaxy and the Antenna Galaxies. The testbed framework is available as open-source to assist other researchers and educators. Recommendations are made for testbed enhancements.

  12. Correlating interleukin-12 stimulated interferon-γ production and the absence of ectodermal dysplasia and anhidrosis (EDA) in patients with mutations in NF-κB essential modulator (NEMO).

    Science.gov (United States)

    Haverkamp, Margje H; Marciano, Beatriz E; Frucht, David M; Jain, Ashish; van de Vosse, Esther; Holland, Steven M

    2014-05-01

    Patients with hypomorphic mutations in Nuclear Factor-κB Essential Modulator (NEMO) are immunodeficient (ID) and most display ectodermal dysplasia and anhidrosis (EDA). We compared cytokine production by NEMO-ID patients with and without EDA. PBMCs of NEMO-ID patients, four with EDA carrying E315A, C417R, D311N and Q403X, and three without EDA carrying E315A, E311_L333del and R254G, were cultured with PHA, PHA plus IL-12p70, LPS, LPS plus IFN-γ, TNF and IL-1β. The production of various cytokines was measured in the supernatants. Fifty-nine healthy individuals served as controls. PBMCs of NEMO-ID patients without EDA produce subnormal amounts of IFN-γ after stimulation with PHA, but normal amounts of IFN-γ after PHA plus IL-12p70. In contrast, IFN-γ production by patients with EDA was low in both cases. Patients with EDA also generate lower PHA-stimulated IL-10 and IL-1β than controls, whereas the production of these cytokines by patients without EDA was normal. Responses of PBMCs in NEMO-ID patients with EDA to PHA with and without IL-12p70 appear less robust than in NEMO-ID patients without EDA. This possibly indicates a better preserved NEMO function in our patients without EDA.

  13. Study of water masses variability in the Mediterranean Sea using in-situ data / NEMO-Med12 model.

    Science.gov (United States)

    Margirier, Félix; Testor, Pierre; Mortier, Laurent; Arsouze, Thomas; Bosse, Anthony; Houpert, Loic; Hayes, Dan

    2016-04-01

    In the past 10 years, numerous observation programs in the Mediterranean deployed autonomous platforms (moorings, argo floats, gliders) and thus considerably increased the number of in-situ observations and the data coverage. In this study, we analyse time series built with profile data on interannual scales. Sorting data in regional boxes, we follow the evolution of different water masses in the basin and generate indexes to characterize their evolution. We then put those indexes in relation with external (atmospheric) forcings and present an intercomparison with the NEMO-Med12 model to estimate both the skill of the model and the relevance of the data-sampling in reproducing the evolution of water masses properties.

  14. Measurement of the two neutrino double beta decay half-life of Zr-96 with the NEMO-3 detector

    Energy Technology Data Exchange (ETDEWEB)

    Argyriades, J. [LAL, Universite Paris-Sud 11, CNRS/IN2P3, F-91405 Orsay (France); Arnold, R. [IPHC, Universite de Strasbourg, CNRS/IN2P3, F-67037 Strasbourg (France); Augier, C. [LAL, Universite Paris-Sud 11, CNRS/IN2P3, F-91405 Orsay (France); Baker, J. [INL, Idaho National Laboratory, 83415 Idaho Falls (United States); Barabash, A.S. [ITEP, Institute of Theoretical and Experimental Physics, 117259 Moscow (Russian Federation); Basharina-Freshville, A. [University College London, WC1E 6BT London (United Kingdom); Bongrand, M. [LAL, Universite Paris-Sud 11, CNRS/IN2P3, F-91405 Orsay (France); Broudin-Bay, G. [Universite Bordeaux, CENBG, UMR 5797, F-33175 Gradignan (France); CNRS/IN2P3, Centre d' Etudes Nucleaires de Bordeaux Gradignan, UMR5797, F-33175 Gradignan (France); Brudanin, V. [JINR, Joint Institute for Nuclear Research, 141980 Dubna (Russian Federation); Caffrey, A.J. [INL, Idaho National Laboratory, 83415 Idaho Falls (United States); Chapon, A. [LPC, ENSICAEN, Universite de Caen, CNRS/IN2P3, F-14032 Caen (France); Chauveau, E. [Universite Bordeaux, CENBG, UMR 5797, F-33175 Gradignan (France); CNRS/IN2P3, Centre d' Etudes Nucleaires de Bordeaux Gradignan, UMR5797, F-33175 Gradignan (France); Daraktchieva, Z. [University College London, WC1E 6BT London (United Kingdom); Durand, D. [LPC, ENSICAEN, Universite de Caen, CNRS/IN2P3, F-14032 Caen (France); Egorov, V. [JINR, Joint Institute for Nuclear Research, 141980 Dubna (Russian Federation); Fatemi-Ghomi, N. [University of Manchester, M13 9PL Manchester (United Kingdom); Flack, R. [University College London, WC1E 6BT London (United Kingdom); Guillon, B. [LPC, ENSICAEN, Universite de Caen, CNRS/IN2P3, F-14032 Caen (France); Hubert, Ph. [Universite Bordeaux, CENBG, UMR 5797, F-33175 Gradignan (France); CNRS/IN2P3, Centre d' Etudes Nucleaires de Bordeaux Gradignan, UMR5797, F-33175 Gradignan (France); Jullian, S. [LAL, Universite Paris-Sud 11, CNRS/IN2P3, F-91405 Orsay (France)

    2010-12-08

    Using 9.4 g of {sup 96}Zr isotope and 1221 days of data from the NEMO-3 detector corresponding to 0.031 kg y, the obtained 2{nu}{beta}{beta} decay half-life measurement is T{sub 1/2}{sup 2{nu}=}[2.35{+-}0.14(stat){+-}0.16(syst)]x10{sup 19} yr. Different characteristics of the final state electrons have been studied, such as the energy sum, individual electron energy, and angular distribution. The 2{nu} nuclear matrix element is extracted using the measured 2{nu}{beta}{beta} half-life and is M{sup 2{nu}=}0.049{+-}0.002. Constraints on 0{nu}{beta}{beta} decay have also been set.

  15. Analysis of the data from the NEMO3 experiment and search for neutrinoless double beta decay - Study of systematic bias of the calorimeter and development of analysis tools

    International Nuclear Information System (INIS)

    Hugon, C.

    2012-11-01

    The NEMO3 experiment was researching the neutrinoless double-β (0ndb) decay by using various sources of double beta decay isotopes (mainly 100 Mo, 82 Se, 116 Cd and 130 Te for about 10 kg in total). The detector was located in the underground laboratory of Modane (Italy) in the halfway point of the Frejus tunnel. This experiment demonstrated that the 'tracko-calo' technology is really competitive and, in addition, it gives new results for the 2-neutrinos double-β (2ndb) decay and the (0ndb) decays research. Moreover it opened an new way for its successor SuperNEMO, which aim is to reach a mass of 100 kg of 82 Se (for a sensitivity of 10 26 years). The main goal of the thesis is to measure the 2ndb and 0ndb decay of the 100 Mo to the excited state 0 1 + of the 100 Ru thanks to the whole NEMO3 data, with new original methods of analysis and through the development of the collaboration analysis software. The results obtained for the ground states (gs) and excited states 2ndb of the 100 Mo are for the half-lives: T(2nbd, gs)=[7.05±0.01(stat)±0.54(syst)]*10 18 years and T(2ndb, 0 1 + )=[6.15±1.1(sta)±0.78]*10 20 years. Those results are compatibles with the last ones published by the collaboration. For the 0ndb(0 1 + ), this work gave a half-life of T(0ndb, 0 1 + ) > 2.6*10 23 years, improving significantly the last published results. Furthermore those methods also allowed to present a new and more exhaustive background noise model for this experiment. The second point of this work was to measure the systematics errors of the NEMO3 calorimeter, among others due to the wavelength of the NEMO3 calibration systems. This work was done using a new test bench based on LED. This bench also allowed to contribute to the development of the SuperNEMO calorimeter, especially in the time characteristic and the energy linearity measurement of the photomultiplier intended to the demonstrator of the experiments. (author)

  16. Van gen naar ziekte; incontinentia pigmenti en het NEMO-gen. [From gene to disease; incontinentia pigmenti and the NEMO-gene

    NARCIS (Netherlands)

    Oranje, A.P.; Arts, W.F.; Wagner, A.; van der Hout, A.H.; Simonsz, H.J.

    2005-01-01

    : Incontinentia pigmenti (IP; MIM308310) is a rare neurocutaneous X-dominant inherited disorder. Besides skin and neurological abnormalities, there is also ophthalmologic and dental involvement. The first stage is characterised by inflammation and apoptosis of the skin and central nervous system.

  17. Double-beta decay measurement of 100Mo to the excited 01+ state of 100Ru in the NEMO3 experiment - R/D program for SuperNEMO: development of a BiPo detector to measure ultra low contaminations in the source foils

    International Nuclear Information System (INIS)

    Chapon, A.

    2011-10-01

    The NEMO3 detector was designed for the study of double beta decay and in particular the search for neutrinoless double beta decay (ββ0ν). The quantity of 100 Mo in the detector (7 kg) allows also a competitive measurement of the two-neutrino double beta decay (ββ2ν) of 100 Mo to the excited 0 1 + state of 100 Ru (eeNγ channel). Monte-Carlo simulations of the effect and of all the possible sources of background have been studied in order to determine their contributions to the full NEMO3 experimental data (2003-2011). These one have then been analysed: the ββ2ν decay half-life has been measured, and a limit on the ββ0ν decay has been obtained. Moreover, the SuperNEMO experiment aims to reach a sensitivity up to 10 26 years on the half-life of neutrinoless double beta decay. The SuperNEMO detector radioactivity has to be as low as possible. Especially radio-purity levels of 2 μBq*kg -1 in 208 Tl and 10 μBq*kg -1 in 214 Bi are required for the source foils. The gamma-spectrometry can not measure such low contamination levels. Hence, a BiPo dedicated detector has been developed to measure 208 Tl and 214 Bi contaminations, identifying the Bi→Po→Pb β-α chains. A proof of principle has been performed and the detector background has been measured. Assuming these values, a full BiPo detector of 3.6 m 2 can achieve the required sensitivities for the SuperNEMO source foils within six months of measurement. (author)

  18. NEMO-SMO acoustic array: A deep-sea test of a novel acoustic positioning system for a km3-scale underwater neutrino telescope

    Science.gov (United States)

    Viola, S.; Ardid, M.; Bertin, V.; Enzenhöfer, A.; Keller, P.; Lahmann, R.; Larosa, G.; Llorens, C. D.; NEMO Collaboration; SMO Collaboration

    2013-10-01

    Within the activities of the NEMO project, the installation of a 8-floors tower (NEMO-Phase II) at a depth of 3500 m is foreseen in 2012. The tower will be installed about 80 km off-shore Capo Passero, in Sicily. On board the NEMO tower, an array of 18 acoustic sensors will be installed, permitting acoustic detection of biological sources, studies for acoustic neutrino detection and primarily acoustic positioning of the underwater structures. For the latter purpose, the sensors register acoustic signals emitted by five acoustic beacons anchored on the sea-floor. The data acquisition system of the acoustic sensors is fully integrated with the detector data transport system and is based on an “all data to shore” philosophy. Signals coming from hydrophones are continuously sampled underwater at 192 kHz/24 bit and transmitted to shore through an electro-optical cable for real-time analysis. A novel technology for underwater GPS time-stamping of data has been implemented and tested. The operation of the acoustic array will permit long-term test of sensors and electronics technologies that are proposed for the acoustic positioning system of KM3NeT.

  19. Captain Nemo/Lt-General Pitt Rivers and Cleopatra’s Needle — A Story of Flagships

    Directory of Open Access Journals (Sweden)

    Christopher Evans

    2005-11-01

    Full Text Available Recently re-reading Verne’s 20,000 Leagues Beneath the Sea for our children I was struck by the marked similarities between the novel’s elusive protagonist, Captain Nemo, and the renowned later 19th century British archaeologist, Lt.-General Pitt Rivers. Could they have been the same person? How could something so seemingly blatant have gone unnoticed? These questions are, of course, only raised in a spirit of academic tongue-in-check. Yet, in an ethos of ‘learning through amusement’ (itself directly relevant to the themes of this study, exploring the parallels between these two ‘heroic’ individuals provides insights into the nature of 19th century science, Victorian edification and disciplinary institutionalisation (e.g. Levine 1986. This eclectic contribution will, moreover, be introduced with the third component of its headline title – Cleopatra’s Needle – as this provides an appropriately quasinautical parable on the project of 19th century archaeology and the problem of ‘deep time’ (Murray 1993.

  20. Response of water temperature to surface wave effects in the Baltic Sea: simulations with the coupled NEMO-WAM model

    Science.gov (United States)

    Alari, Victor; Staneva, Joanna; Breivik, Øyvind; Bidlot, Jean-Raymond; Mogensen, Kristian; Janssen, Peter

    2016-04-01

    The effects of wind waves on the Baltic Sea water temperature has been studied by coupling the hydrodynamical model NEMO with the wave model WAM. The wave forcing terms that have been taken into consideration are: Stokes-Coriolis force, seastate dependent energy flux and sea-state dependent momentum flux. The combined role of these processes as well as their individual contributions on simulated temperature is analysed. The results indicate a pronounced effect of waves on surface temperature, on the distribution of vertical temperature and on upwellinǵs. In northern parts of the Baltic Sea a warming of the surface layer occurs in the wave included simulations. This in turn reduces the cold bias between simulated and measured data. The warming is primarily caused by sea-state dependent energy flux. Wave induced cooling is mostly observed in near coastal areas and is mainly due to Stokes-Coriolis forcing. The latter triggers effect of intensifying upwellings near the coasts, depending on the direction of the wind. The effect of sea-state dependent momentum flux is predominantly to warm the surface layer. During the summer the wave induced water temperature changes were up to 1 °C.

  1. Nemo Solus Satis Sapit: Trends of Research Collaborations in the Vietnamese Social Sciences, Observing 2008–2017 Scopus Data

    Directory of Open Access Journals (Sweden)

    Quan-Hoang Vuong

    2017-10-01

    Full Text Available “Nemo solus satis sapit”—no one can be wise enough on his own. This is particularly true when it comes to collaborations in scientific research. Concerns over this issue in Vietnam, a developing country with limited academic resources, led to an in-depth study on Vietnamese social science research, using Google Scholar and Scopus, during 2008–2017. The results showed that more than 90% of scientists had worked with colleagues to publish, and they had collaborated 13 times on average during the time limit of the data sample. These collaborations, both domestic and international, mildly boosted author performance. On the other hand, the modest number of publications by Vietnamese authors was reportedly linked to Vietnamese social scientists’ heavy reliance on collaborative work as non-leading co-authors: for an entire decade (2008–2017, the average author assumes the leading role merely in two articles, and hardly ever published alone. This implies that policy-makers ought to consider promoting institutional collaborations while also encouraging authors to acquire the experience of publishing solo.

  2. AMM15: a new high-resolution NEMO configuration for operational simulation of the European north-west shelf

    Science.gov (United States)

    Graham, Jennifer A.; O'Dea, Enda; Holt, Jason; Polton, Jeff; Hewitt, Helene T.; Furner, Rachel; Guihou, Karen; Brereton, Ashley; Arnold, Alex; Wakelin, Sarah; Castillo Sanchez, Juan Manuel; Mayorga Adame, C. Gabriela

    2018-02-01

    This paper describes the next-generation ocean forecast model for the European north-west shelf, which will become the basis of operational forecasts in 2018. This new system will provide a step change in resolution and therefore our ability to represent small-scale processes. The new model has a resolution of 1.5 km compared with a grid spacing of 7 km in the current operational system. AMM15 (Atlantic Margin Model, 1.5 km) is introduced as a new regional configuration of NEMO v3.6. Here we describe the technical details behind this configuration, with modifications appropriate for the new high-resolution domain. Results from a 30-year non-assimilative run using the AMM15 domain demonstrate the ability of this model to represent the mean state and variability of the region.Overall, there is an improvement in the representation of the mean state across the region, suggesting similar improvements may be seen in the future operational system. However, the reduction in seasonal bias is greater off-shelf than on-shelf. In the North Sea, biases are largely unchanged. Since there has been no change to the vertical resolution or parameterization schemes, performance improvements are not expected in regions where stratification is dominated by vertical processes rather than advection. This highlights the fact that increased horizontal resolution will not lead to domain-wide improvements. Further work is needed to target bias reduction across the north-west shelf region.

  3. Super-resolution microscopy reveals a preformed NEMO lattice structure that is collapsed in incontinentia pigmenti

    CSIR Research Space (South Africa)

    Scholefield, Janine

    2016-09-01

    Full Text Available Boucharlat4, Emmanuel Laplantine5, Asma Smahi6, Alain Israe¨l5, Fabrice Agou4 & Musa M. Mhlanga1,2,7 The NF-kB pathway has critical roles in cancer, immunity and inflammatory responses. Understanding the mechanism(s) by which mutations in genes involved...

  4. Thermodynamic and dynamic ice thickness contributions in the Canadian Arctic Archipelago in NEMO-LIM2 numerical simulations

    Science.gov (United States)

    Hu, Xianmin; Sun, Jingfan; Chan, Ting On; Myers, Paul G.

    2018-04-01

    Sea ice thickness evolution within the Canadian Arctic Archipelago (CAA) is of great interest to science, as well as local communities and their economy. In this study, based on the NEMO numerical framework including the LIM2 sea ice module, simulations at both 1/4 and 1/12° horizontal resolution were conducted from 2002 to 2016. The model captures well the general spatial distribution of ice thickness in the CAA region, with very thick sea ice (˜ 4 m and thicker) in the northern CAA, thick sea ice (2.5 to 3 m) in the west-central Parry Channel and M'Clintock Channel, and thin ( Program data at first-year landfast ice sites except at the northern sites with high concentration of old ice. At 1/4 to 1/12° scale, model resolution does not play a significant role in the sea ice simulation except to improve local dynamics because of better coastline representation. Sea ice growth is decomposed into thermodynamic and dynamic (including all non-thermodynamic processes in the model) contributions to study the ice thickness evolution. Relatively smaller thermodynamic contribution to ice growth between December and the following April is found in the thick and very thick ice regions, with larger contributions in the thin ice-covered region. No significant trend in winter maximum ice volume is found in the northern CAA and Baffin Bay while a decline (r2 ≈ 0.6, p < 0.01) is simulated in Parry Channel region. The two main contributors (thermodynamic growth and lateral transport) have high interannual variabilities which largely balance each other, so that maximum ice volume can vary interannually by ±12 % in the northern CAA, ±15 % in Parry Channel, and ±9 % in Baffin Bay. Further quantitative evaluation is required.

  5. Comparative study of sea ice dynamics simulations with a Maxwell elasto-brittle rheology and the elastic-viscous-plastic rheology in NEMO-LIM3

    Science.gov (United States)

    Raulier, Jonathan; Dansereau, Véronique; Fichefet, Thierry; Legat, Vincent; Weiss, Jérôme

    2017-04-01

    Sea ice is a highly dynamical environment characterized by a dense mesh of fractures or leads, constantly opening and closing over short time scales. This characteristic geomorphology is linked to the existence of linear kinematic features, which consist of quasi-linear patterns emerging from the observed strain rate field of sea ice. Standard rheologies used in most state-of-the-art sea ice models, like the well-known elastic-viscous-plastic rheology, are thought to misrepresent those linear kinematic features and the observed statistical distribution of deformation rates. Dedicated rheologies built to catch the processes known to be at the origin of the formation of leads are developed but still need evaluations on the global scale. One of them, based on a Maxwell elasto-brittle formulation, is being integrated in the NEMO-LIM3 global ocean-sea ice model (www.nemo-ocean.eu; www.elic.ucl.ac.be/lim). In the present study, we compare the results of the sea ice model LIM3 obtained with two different rheologies: the elastic-viscous-plastic rheology commonly used in LIM3 and a Maxwell elasto-brittle rheology. This comparison is focused on the statistical characteristics of the simulated deformation rate and on the ability of the model to reproduce the existence of leads within the ice pack. The impact of the lead representation on fluxes between ice, atmosphere and ocean is also assessed.

  6. Results of the BiPo-1 prototype for radiopurity measurements for the SuperNEMO double beta decay source foils

    Energy Technology Data Exchange (ETDEWEB)

    Argyriades, J. [LAL, Universite Paris-Sud, CNRS/IN2P3, F-91405 Orsay (France); Arnold, R. [IPHC, Universite de Strasbourg, CNRS/IN2P3, F-67037 Strasbourg (France); Augier, C. [LAL, Universite Paris-Sud, CNRS/IN2P3, F-91405 Orsay (France); Baker, J. [INL, Idaho Falls, ID 83415 (United States); Barabash, A.S. [Institute of Theoretical and Experimental Physics, 117259 Moscow (Russian Federation); Basharina-Freshville, A. [University College London, WC1E 6BT London (United Kingdom); Bongrand, M.; Bourgeois, C.; Breton, D.; Briere, M.; Broudin-Bay, G. [LAL, Universite Paris-Sud, CNRS/IN2P3, F-91405 Orsay (France); Brudanin, V.B. [Joint Institute for Neear Research, 141980 Dubna (Russian Federation); Caffrey, A.J. [INL, Idaho Falls, ID 83415 (United States); Carcel, S. [Instituto de Fisica Corpuscular, CSIC, Universidad de Valencia, Valencia (Spain); Cebrian, S. [Instituto de Fisica Nuclear y Altas Energias, Universidad de Zaragoza, Zaragoza (Spain); Chapon, A. [LPC Caen, ENSICAEN, Universite de Caen, CNRS/IN2P3, F-14032 Caen (France); Chauveau, E. [CNRS/IN2P3, Centre d' Etudes Nucleaires de Bordeaux Gradignan, UMR 5797, F-33175 Gradignan (France); Universite de Bordeaux, Centre d' Etudes Nucleaires de Bordeaux Gradignan, UMR 5797, F-33175 Gradignan (France); Dafni, Th. [Instituto de Fisica Nuclear y Altas Energias, Universidad de Zaragoza, Zaragoza (Spain); Diaz, J. [Instituto de Fisica Corpuscular, CSIC, Universidad de Valencia, Valencia (Spain); Durand, D. [LPC Caen, ENSICAEN, Universite de Caen, CNRS/IN2P3, F-14032 Caen (France)

    2010-10-01

    The development of BiPo detectors is dedicated to the measurement of extremely high radiopurity in {sup 208}Tl and {sup 214}Bi for the SuperNEMO double beta decay source foils. A modular prototype, called BiPo-1, with 0.8 m{sup 2} of sensitive surface area, has been running in the Modane Underground Laboratory since February, 2008. The goal of BiPo-1 is to measure the different components of the background and in particular the surface radiopurity of the plastic scintillators that make up the detector. The first phase of data collection has been dedicated to the measurement of the radiopurity in {sup 208}Tl. After more than one year of background measurement, a surface activity of the scintillators of A({sup 208}Tl)=1.5{mu}Bq/m{sup 2} is reported here. Given this level of background, a larger BiPo detector having 12 m{sup 2} of active surface area, is able to qualify the radiopurity of the SuperNEMO selenium double beta decay foils with the required sensitivity of A({sup 208}Tl)<2{mu}Bq/kg (90% C.L.) with a six month measurement.

  7. Suppression of nemo-like kinase by miR-71 in Echinococcus multilocularis.

    Science.gov (United States)

    Guo, Xiaola; Zhang, Xueyong; Yang, Jing; Jin, Xiaoliang; Ding, Juntao; Xiang, Haitao; Ayaz, Mazhar; Luo, Xuenong; Zheng, Yadong

    2017-12-01

    Echinococcus multilocularis metacestodes are a causative pathogen for alveolar echinococcosis in human beings, and have been found to express miRNAs including emu-miR-71. miR-71 is evolutionarily conserved and highly expressed across platyhelminths, but little is known about its role. Here it was shown that emu-miR-71 was differentially expressed in protoscoleces and was unlikely to be expressed in neoblasts. The results of the luciferase assay indicated that emu-miR-71 was able to bind in vitro to the 3'-UTR of emu-nlk, encoding a key regulator of cell division, causing significant downregulation of luciferase activity (p < 0.01) compared to the negative control and the construct with mutations in the binding site. Consistent with the decreased luciferase activity, transfection of emu-miR-71 mimics into protoscoleces notably repressed emu-NLK (p < 0.05). These results demonstrate the suppression of emu-nlk by emu-miR-71, potentially involved in the protoscolex development. Copyright © 2017 Elsevier Inc. All rights reserved.

  8. Nemo-like kinase as a negative regulator of nuclear receptor Nurr1 gene transcription in prostate cancer

    International Nuclear Information System (INIS)

    Wang, Jian; Yang, Zhi-Hong; Chen, Hua; Li, Hua-Hui; Chen, Li-Yong; Zhu, Zhu; Zou, Ying; Ding, Cong-Cong; Yang, Jing; He, Zhi-Wei

    2016-01-01

    Nurr1, a member of the orphan receptor family, plays an important role in several types of cancer. Our previous work demonstrated that increased expression of Nurr1 plays a significant role in the initiation and progression of prostate cancer (PCa), though the mechanisms for regulation of Nurr1 expression remain unknown. In this study, we investigated the hypothesis that Nemo-like kinase (NLK) is a key regulator of Nurr1 expression in PCa. Immunohistochemistry and Western blot analysis were used to evaluate levels of NLK and Nurr1 in prostatic tissues and cell lines. The effects of overexpression or knockdown of Nurr1 were evaluated in PCa cells through use of PCR, Western blots and promoter reporter assays. The role of Nurr1 promoter cis element was studied by creation of two mutant Nurr1 promoter luciferase constructs, one with a mutated NF-κB binding site and one with a mutated CREB binding site. In addition, three specific inhibitors were used to investigate the roles of these proteins in transcriptional activation of Nurr1, including BAY 11–7082 (NF-κB inhibitor), KG-501 (CREB inhibitor) and ICG-001 (CREB binding protein, CBP, inhibitor). The function of CBP in NLK-mediated regulation of Nurr1 expression was investigated using immunofluorescence, co-immunoprecipitation (Co-IP) and chromatin immunoprecipitation assays (ChIPs). NLK expression was inversely correlated with Nurr1 expression in prostate cancer tissues and cell lines. Overexpression of NLK suppressed Nurr1 promoter activity, leading to downregulation of Nurr1 expression. In contrast, knockdown of NLK demonstrated opposite results, leading to upregulation of Nurr1. When compared with the wild-type Nurr1 promoter, mutation of NF-κB- and CREB-binding sites of the Nurr1 promoter region significantly reduced the upregulation of Nurr1 induced by knockdown of NLK in LNCaP cells; treatment with inhibitors of CREB, CBP and NF-κB led to similar results. We also found that NLK directly interacts with CBP

  9. Hepatic tissue environment in NEMO-deficient mice critically regulates positive selection of donor cells after hepatocyte transplantation.

    Directory of Open Access Journals (Sweden)

    Michaela Kaldenbach

    Full Text Available BACKGROUND: Hepatocyte transplantation (HT is a promising alternative treatment strategy for end-stage liver diseases compared with orthotopic liver transplantation. A limitation for this approach is the low engraftment of donor cells. The deletion of the I-kappa B kinase-regulatory subunit IKKγ/NEMO in hepatocytes prevents nuclear factor (NF-kB activation and triggers spontaneous liver apoptosis, chronic hepatitis and the development of liver fibrosis and hepatocellular carcinoma. We hypothesized that NEMOΔhepa mice may therefore serve as an experimental model to study HT. METHODS: Pre-conditioned NEMOΔhepa mice were transplanted with donor-hepatocytes from wildtype (WT and mice deficient for the pro-apoptotic mediator Caspase-8 (Casp8Δhepa. RESULTS: Transplantation of isolated WT-hepatocytes into pre-conditioned NEMOΔhepa mice resulted in a 6-7 fold increase of donor cells 12 weeks after HT, while WT-recipients showed no liver repopulation. The use of apoptosis-resistant Casp8Δhepa-derived donor cells further enhanced the selection 3-fold after 12-weeks and up to 10-fold increase after 52 weeks compared with WT donors. While analysis of NEMOΔhepa mice revealed strong liver injury, HT-recipient NEMOΔhepa mice showed improved liver morphology and decrease in serum transaminases. Concomitant with these findings, the histological examination elicited an improved liver tissue architecture associated with significantly lower levels of apoptosis, decreased proliferation and a lesser amount of liver fibrogenesis. Altogether, our data clearly support the therapeutic benefit of the HT procedure into NEMOΔhepa mice. CONCLUSION: This study demonstrates the feasibility of the NEMOΔhepa mouse as an in vivo tool to study liver repopulation after HT. The improvement of the characteristic phenotype of chronic liver injury in NEMOΔhepa mice after HT suggests the therapeutic potential of HT in liver diseases with a chronic inflammatory phenotype and

  10. Search for evidence of lepton number violation by neutrinoless double beta decay process from 82Se and 150Nd in NEMO-3 experiment: Bi-Po decay study from thoron chain

    International Nuclear Information System (INIS)

    Lemiere, Y.

    2008-09-01

    The NEMO-3 experiment searches for a neutrinoless double beta decay signal (ββ0ν) with an expected sensitivity in terms of the half-life limit of the order of 10 24 years. The discovery of this signal, forbidden in the Standard Model, would imply the violation of leptonic number conservation and would allow to determine the nature of this particle (Dirac or Majorana) and measure the neutrino mass scale. The goal of this work is to study high energy events from 82 Se and 150 Nd ββ decay used in NEMO-3 detector. The first part of this work consists in the elaboration of a background model using NEMO-3 data. In the second part, the ββ2ν half-life and a lower limit of the ββ0ν half-life are computed using massive Majorana neutrino exchange hypothesis, we have got: T(0ν) > 1.44*10 22 years for 150 Nd and T(0ν) > 1.82*10 23 years for 82 Se. The upper limits for the effective mass of the Majorana neutrinos are also computed, we obtain: m ββ 150 Nd and m ββ 82 Se. In the last part, the measurement of some specific thallium contamination is performed thanks to the NEMO-3 capability to detect the 212 Bi-Po decay. The measured value of the surface contamination of the calorimeter is about (150 ± 30) μBq/m 3 . So the surface contamination is too low to intervene in the data analysis of NEMO-3 but appears important for next generation scintillators

  11. Study of the background of the neutrinoless double {beta} decay with the detector NEMO 2: contribution arising from the radon diffusion and internal pollution of the source {sup 214}Bi have been estimated; Etude du bruit de fond de la double-desintegration {beta} sans emission de neutrino dans le detecteur NEMO 2: contribution du radon ambiant et mesure de la pollution interne de la source en {sup 214}Bi

    Energy Technology Data Exchange (ETDEWEB)

    Mauger, F.

    1995-02-01

    The NEMO experiment is designed to understand the nature of the neutrino by studying the double beta decay of Mo-100 which is related to the Majorana neutrino effective mass. In this kind of experiment a good understanding of the different sources of background is crucial as only few events are expected per year at the required level of sensitivity. In this thesis we present the main theoretical and experimental aspects of the measurement of the neutrinoless double beta decay of Mo-100 with the prototype detector NEMO2. The goal of this study is to obtain a realistic interpretation of the few events detected at high energy in the two-electron channel as a background to neutrinoless double beta decay. In particular, the contribution arising from Bi-214 has been investigated. These events have been selected and analysed by means of the beta-alpha decays of Bi-214 into Pb-210. The events are characterized by a delayed track in the wire chamber and the corresponding signal is rather clean. The study has demonstrated the diffusion of Rn-222 into the detector and its contribution to Bi-214 pollution has been estimated. A measurement of the Bi-214 internal contamination of the source has been made as well as an estimation of the Bi-214 deposit due to Rn-222. As a result of this study it appears that, under the conditions of the NEMO2 experiment, the Bi and Rn contributions are of the same order of magnitude as the background induced at high energy by two-neutrino double beta decay. In conclusion, the backgrounds of the neutrinoless double beta decay of Mo-100 are well understood in the NEMO2 experiment leading to an extrapolation for the NEMO3 experiment. (authors).

  12. Development from the seafloor to the sea surface of the cabled NEMO-SN1 observatory in the Western Ionian Sea

    Science.gov (United States)

    Sparnocchia, Stefania; Beranzoli, Laura; Borghini, Mireno; Durante, Sara; Favali, Paolo; Giovanetti, Gabriele; Italiano, Francesco; Marinaro, Giuditta; Meccia, Virna; Papaleo, Riccardo; Riccobene, Giorgio; Schroeder, Katrin

    2015-04-01

    A prototype of cabled deep-sea observatory has been operating in real-time since 2005 in Southern Italy (East Sicily, 37°30' N - 15°06'E), at 2100 m water depth, 25 km from the harbor of the city of Catania. It is the first-established real-time node of the "European Multidisciplinary Seafloor and water column Observatory" (EMSO, http://www.emso-eu.org) a research infrastructure of the Sector Environment of ESFRI. In the present configuration it consists of two components: the multi-parametric station NEMO-SN1 (TSN branch) equipped with geophysical and environmental sensors for measurements at the seafloor, and the NEMO-OνDE station (TSS branch) equipped with 4 wideband hydrophones. A 28 km long electro-optical cable connects the observatory to a shore laboratory in the Catania harbor, hosting the data acquisition system and supplying power and data transmission to the underwater instrumentation. The NEMO-SN1 observatory is located in an area particularly suited to multidisciplinary studies. The site is one of the most seismically active areas of the Mediterranean (some of the strongest earthquakes occurred in 1169, 1693 and 1908, also causing very intense tsunami waves) and is close to Mount Etna, one of the largest and most active volcanoes in Europe. The deployment area is also a key site for monitoring deep-water dynamics in the Ionian Sea, connecting the Levantine basin to the southern Adriatic basin where intermediate and deep waters are formed, and finally to the western Mediterranean Sea via the Strait of Sicily. The observatory is being further developed under EMSO MedIT (http://www.emso-medit.it/en/), a structural enhancement project contributing to the consolidation and enhancement of the European research infrastructure EMSO in Italian Convergence Regions. In this framework, a new Junction Box will be connected to the TSN branch and will provide wired and wireless (acoustic connections) for seafloor platforms and moorings. This will allow the

  13. Implementation of the NEMO model for estimating the spread of leakage from chemical munitions in the Baltic Sea - the first approach

    Science.gov (United States)

    Andrzejewski, Jan

    2017-04-01

    After the Second World War, during the Potsdam Conference a decision about demilitarization of Germany was made, and as a consequence, ammunition including chemical warfare agents (CWA) was dumped into the basins of the Baltic Sea. This type of weapon was stored in metal barrels that were under strong influence of electrochemical oxidation, also known as corrosion. Several tens years later, scientists were wondering what consequences for marine ecosystem could a leakage from this weapon bring. Although over 70 years passed since the Second World War, the influence of potential leakage of the CWA has not been properly estimated. Thus, the main goal of this work is to estimate dangerous area caused by potential leakage using the NEMO (Nucleus for European Modelling of the Ocean) ocean model. The NEMO ocean model is developed by the European Consortium including research institutes from France, England and Italy. The first step of this work is to implement the model for the area of the Baltic Sea. It requires generation of horizontal and vertical grid, bathymetry, atmospheric forces and lateral boundary conditions. Implemented model will have to be checked - it means it will have to pass a validation process. The Baltic Sea is one of the best measured sea in the World - as a consequence a lot of data are freely available for researchers. After validation and tuning up the model, implementation of passive tracer is planned. Passive tracer is the prognostic variable that could represent concentration of potential leakage and does not have influence on the density of the model. Based on distribution of the passive tracer, dangerous areas in the locations of dumpsites will be assessed. The research work was funded by the European Union (European Regional Development Fund) under the Interreg Baltic Sea Region Programme 2014-2020, project #R013 DAIMON (Decision Aid for Marine Munitions).

  14. Measurement of the 2νββ decay of 100Mo to the excited 01+ state in the NEMO3 experiment

    International Nuclear Information System (INIS)

    Vala, L.

    2003-09-01

    The NEMO3 detector was designed for the study of double beta decay and in particular to search for the neutrinoless double beta decay process (0νββ). The intended sensitivity in terms of a half-life limit for the 0νββ decay is of the order of 10 25 y which corresponds to an effective neutrino mass m ν on the level of (0.3 - 0.1) eV. The 0νββ process is today the most promising test of the Majorana nature of the neutrino. The detector was constructed in the Modane Underground Laboratory (LSM) in France by an international collaboration including France, Russia, the Czech Republic, the USA, the UK, Finland, and Japan. The experiment has been taking data since May 2002. The quantity of 100 Mo in the detector (7 kg) allows an efficient measurement of the two-neutrino double beta decay (2νββ) of 100 Mo to the excited 0 1 + state (eeNγ channel). Monte-Carlo simulations of the effect and of all the relative sources of background have been produced in order to define a set of appropriate selection criteria. Both Monte-Carlo simulations and special runs with sources of 208 Tl and 214 Bi showed that the only significant background in the eeNγ channel comes from radon that penetrated inside the wire chamber of NEMO3. The experimental data acquired from May 2002 to May 2003 have been analysed in order to determine the signal from the 2νββ decay of 100 Mo to the excited 0 1 + state and the corresponding background level. The physical result, which was obtained at the level of four standard deviations, is given in the form of an interval of half-life values at 95% confidence level: [5.84*10 20 , 2.26*10 21 ] y for method A and [5.83*10 20 , 1.71*10 21 ] y for method B. (author)

  15. Measurement of the 2{nu}{beta}{beta} decay of {sup 100}Mo to the excited 0{sub 1}{sup +} state in the NEMO3 experiment

    Energy Technology Data Exchange (ETDEWEB)

    Vala, L

    2003-09-01

    The NEMO3 detector was designed for the study of double beta decay and in particular to search for the neutrinoless double beta decay process (0{nu}{beta}{beta}). The intended sensitivity in terms of a half-life limit for the 0{nu}{beta}{beta} decay is of the order of 10{sup 25} y which corresponds to an effective neutrino mass m{sub {nu}} on the level of (0.3 - 0.1) eV. The 0{nu}{beta}{beta} process is today the most promising test of the Majorana nature of the neutrino. The detector was constructed in the Modane Underground Laboratory (LSM) in France by an international collaboration including France, Russia, the Czech Republic, the USA, the UK, Finland, and Japan. The experiment has been taking data since May 2002. The quantity of {sup 100}Mo in the detector (7 kg) allows an efficient measurement of the two-neutrino double beta decay (2{nu}{beta}{beta}) of {sup 100}Mo to the excited 0{sub 1}{sup +} state (eeN{gamma} channel). Monte-Carlo simulations of the effect and of all the relative sources of background have been produced in order to define a set of appropriate selection criteria. Both Monte-Carlo simulations and special runs with sources of {sup 208}Tl and {sup 214}Bi showed that the only significant background in the eeN{gamma} channel comes from radon that penetrated inside the wire chamber of NEMO3. The experimental data acquired from May 2002 to May 2003 have been analysed in order to determine the signal from the 2{nu}{beta}{beta} decay of {sup 100}Mo to the excited 0{sub 1}{sup +} state and the corresponding background level. The physical result, which was obtained at the level of four standard deviations, is given in the form of an interval of half-life values at 95% confidence level: [5.84*10{sup 20}, 2.26*10{sup 21}] y for method A and [5.83*10{sup 20}, 1.71*10{sup 21}] y for method B. (author)

  16. NEMO. A novel techno-economic tool suite for simulating and optimizing solutions for grid integration of electric vehicles and charging stations

    Energy Technology Data Exchange (ETDEWEB)

    Erge, Thomas; Stillahn, Thies; Dallmer-Zerbe, Kilian; Wille-Haussmann, Bernhard [Frauenhofer Institut for Solar Energy Systems ISE, Freiburg (Germany)

    2013-07-01

    With an increasing use of electric vehicles (EV) grid operators need to predict energy flows depending on electromobility use profiles to accordingly adjust grid infrastructure and operation control accordingly. Tools and methodologies are required to characterize grid problems resulting from the interconnection of EV with the grid. The simulation and optimization tool suite NEMO (Novel E-MObility grid model) was developed within a European research project and is currently being tested using realistic showcases. It is a combination of three professional tools. One of the tools aims at a combined techno-economic design and operation, primarily modeling plants on contracts or the spot market, at the same time participating in balancing markets. The second tool is designed for planning grid extension or reinforcement while the third tool is mainly used to quickly discover potential conflicts of grid operation approaches through load flow analysis. The tool suite is used to investigate real showcases in Denmark, Germany and the Netherlands. First studies show that significant alleviation of stress on distribution grid lines could be achieved by few but intelligent restrictions to EV charging procedures.

  17. Design and Development of nEMoS, an All-in-One, Low-Cost, Web-Connected and 3D-Printed Device for Environmental Analysis

    Directory of Open Access Journals (Sweden)

    Francesco Salamone

    2015-06-01

    Full Text Available The Indoor Environmental Quality (IEQ refers to the quality of the environment in relation to the health and well-being of the occupants. It is a holistic concept, which considers several categories, each related to a specific environmental parameter. This article describes a low-cost and open-source hardware architecture able to detect the indoor variables necessary for the IEQ calculation as an alternative to the traditional hardware used for this purpose. The system consists of some sensors and an Arduino board. One of the key strengths of Arduino is the possibility it affords of loading the script into the board’s memory and letting it run without interfacing with computers, thus granting complete independence, portability and accuracy. Recent works have demonstrated that the cost of scientific equipment can be reduced by applying open-source principles to their design using a combination of the Arduino platform and a 3D printer. The evolution of the 3D printer has provided a new means of open design capable of accelerating self-directed development. The proposed nano Environmental Monitoring System (nEMoS instrument is shown to have good reliability and it provides the foundation for a more critical approach to the use of professional sensors as well as for conceiving new scenarios and potential applications.

  18. Design and development of nEMoS, an all-in-one, low-cost, web-connected and 3D-printed device for environmental analysis.

    Science.gov (United States)

    Salamone, Francesco; Belussi, Lorenzo; Danza, Ludovico; Ghellere, Matteo; Meroni, Italo

    2015-06-04

    The Indoor Environmental Quality (IEQ) refers to the quality of the environment in relation to the health and well-being of the occupants. It is a holistic concept, which considers several categories, each related to a specific environmental parameter. This article describes a low-cost and open-source hardware architecture able to detect the indoor variables necessary for the IEQ calculation as an alternative to the traditional hardware used for this purpose. The system consists of some sensors and an Arduino board. One of the key strengths of Arduino is the possibility it affords of loading the script into the board's memory and letting it run without interfacing with computers, thus granting complete independence, portability and accuracy. Recent works have demonstrated that the cost of scientific equipment can be reduced by applying open-source principles to their design using a combination of the Arduino platform and a 3D printer. The evolution of the 3D printer has provided a new means of open design capable of accelerating self-directed development. The proposed nano Environmental Monitoring System (nEMoS) instrument is shown to have good reliability and it provides the foundation for a more critical approach to the use of professional sensors as well as for conceiving new scenarios and potential applications.

  19. NEMO. A novel techno-economic tool suite for simulating and optimizing solutions for grid integration of electric vehicles and charging stations

    International Nuclear Information System (INIS)

    Erge, Thomas; Stillahn, Thies; Dallmer-Zerbe, Kilian; Wille-Haussmann, Bernhard

    2013-01-01

    With an increasing use of electric vehicles (EV) grid operators need to predict energy flows depending on electromobility use profiles to accordingly adjust grid infrastructure and operation control accordingly. Tools and methodologies are required to characterize grid problems resulting from the interconnection of EV with the grid. The simulation and optimization tool suite NEMO (Novel E-MObility grid model) was developed within a European research project and is currently being tested using realistic showcases. It is a combination of three professional tools. One of the tools aims at a combined techno-economic design and operation, primarily modeling plants on contracts or the spot market, at the same time participating in balancing markets. The second tool is designed for planning grid extension or reinforcement while the third tool is mainly used to quickly discover potential conflicts of grid operation approaches through load flow analysis. The tool suite is used to investigate real showcases in Denmark, Germany and the Netherlands. First studies show that significant alleviation of stress on distribution grid lines could be achieved by few but intelligent restrictions to EV charging procedures.

  20. Analysis method for the search for neutrinoless double beta decay in the NEMO3 experiment: study of the background and first results

    International Nuclear Information System (INIS)

    Etienvre, A.I.

    2003-04-01

    The NEMO3 detector, installed in the Frejus Underground Laboratory, is dedicated to the study of neutrinoless double beta decay: the observation of this process would sign the massive and Majorana nature of neutrino. The experiment consists in very thin central source foils (the total mass is equal to 10 kg), a tracking detector made of drift cells operating in Geiger mode, a calorimeter made of plastic scintillators associated to photomultipliers, a coil producing a 30 gauss magnetic field and two shields, dedicated to the reduction of the γ-ray and neutron fluxes. In the first part, I describe the implications of several mechanisms, related to trilinear R-parity violation, on double beta decay. The second part is dedicated to a detailed study of the tracking detector of the experiment: after a description of the different working tests, I present the determination of the characteristics of the tracking reconstruction (transverse and longitudinal resolution, by Geiger cell and precision on vertex determination, charge recognition). The last part corresponds to the analysis of the data taken by the experiment. On the one hand, an upper limit on the Tl 208 activity of the sources has been determined: it is lower than 68 mBq/kg, at 90% of confidence level. On the other hand, I have developed and tested on these data a method in order to analyse the neutrinoless double beta decay signal; this method is based on a maximum of likelihood using all the available information. Using this method, I could determine a first and very preliminary upper limit on the effective mass of the neutrino. (author)

  1. Impact of miR-208 and its Target Gene Nemo-Like Kinase on the Protective Effect of Ginsenoside Rb1 in Hypoxia/Ischemia Injuried Cardiomyocytes

    Directory of Open Access Journals (Sweden)

    Xu Yan

    2016-09-01

    Full Text Available Background/Aims: Ginsenoside Rb1 (GS-Rb1 is one of the most important active pharmacological extracts of the Traditional Chinese Medicine ginseng, with extensive evidence of its cardioprotective properties. Mir-208 has been shown to act as a biomarker of acute myocardial infarction in vivo studies including man. However the impact of miR-208 on the protective effect of GS-Rb1 in hypoxia/ischemia injured cardiomyocytes remains unclear. The current study aims to investigate the target gene of miR-208 and the impact on the protective effect of GS-Rb1 in hypoxia/ischemia (H/I injuried cardiomyocytes. Materials and Methods: Primary cultures of neonatal rat cardiomyocytes (NRCMs was subjected to the H/I conditions with or without GS-Rb1. Cell viability was calculated by MTT assay and confirmed by flow cytometry analysis. Mir-208 was then detected by qRT-PCR. Luciferase reporter assay was carried out to detect the target gene of Mir-208. Then the NRCMs were transfected with miR-208 mimics and inhibitors to evaluate the impact on cardioprotective properties of Rb1. Results: The miR-208 expression level was clearly upregulated in the H/I treated NRCMs accompanied by the percentage of the apoptotic cells which could be reversed by GS-Rb1 pretreatment. The nemo-like kinase (NLK mRNA and protein expression levels were decreased in H/I group measured by RT-PCR and western blotting. Luciferase activity assay was then carried out to identify that NLK may be a direct target of mir-208. MTT assay showed that miR-208 inhibitor slightly decreased the protective effect of Rb1 on the H/I impaired NRCMs. However, results showed no statistical difference. Conclusions: These findings proved that NLK was a direct target of mir-208 and miR-208 act indirectly during Rb1 protecting H/I impaired NRCMs and further researches were needed to explore the relationship that microRNAs and other signal pathways in the protective effect of GS-Rb1 on the hypoxia/ischemia injuries in

  2. Assessment of the sea-ice carbon pump: Insights from a three-dimensional ocean-sea-ice biogeochemical model (NEMO-LIM-PISCES

    Directory of Open Access Journals (Sweden)

    Sébastien Moreau

    2016-08-01

    Full Text Available Abstract The role of sea ice in the carbon cycle is minimally represented in current Earth System Models (ESMs. Among potentially important flaws, mentioned by several authors and generally overlooked during ESM design, is the link between sea-ice growth and melt and oceanic dissolved inorganic carbon (DIC and total alkalinity (TA. Here we investigate whether this link is indeed an important feature of the marine carbon cycle misrepresented in ESMs. We use an ocean general circulation model (NEMO-LIM-PISCES with sea-ice and marine carbon cycle components, forced by atmospheric reanalyses, adding a first-order representation of DIC and TA storage and release in/from sea ice. Our results suggest that DIC rejection during sea-ice growth releases several hundred Tg C yr−1 to the surface ocean, of which < 2% is exported to depth, leading to a notable but weak redistribution of DIC towards deep polar basins. Active carbon processes (mainly CaCO3 precipitation but also ice-atmosphere CO2 fluxes and net community production increasing the TA/DIC ratio in sea-ice modified ocean-atmosphere CO2 fluxes by a few Tg C yr−1 in the sea-ice zone, with specific hemispheric effects: DIC content of the Arctic basin decreased but DIC content of the Southern Ocean increased. For the global ocean, DIC content increased by 4 Tg C yr−1 or 2 Pg C after 500 years of model run. The simulated numbers are generally small compared to the present-day global ocean annual CO2 sink (2.6 ± 0.5 Pg C yr−1. However, sea-ice carbon processes seem important at regional scales as they act significantly on DIC redistribution within and outside polar basins. The efficiency of carbon export to depth depends on the representation of surface-subsurface exchanges and their relationship with sea ice, and could differ substantially if a higher resolution or different ocean model were used.

  3. Evaluation of an operational ocean model configuration at 1/12° spatial resolution for the Indonesian seas (NEMO2.3/INDO12) - Part 1: Ocean physics

    Science.gov (United States)

    Tranchant, Benoît; Reffray, Guillaume; Greiner, Eric; Nugroho, Dwiyoga; Koch-Larrouy, Ariane; Gaspar, Philippe

    2016-03-01

    INDO12 is a 1/12° regional version of the NEMO physical ocean model covering the whole Indonesian EEZ (Exclusive Economic Zone). It has been developed and is now running every week in the framework of the INDESO (Infrastructure Development of Space Oceanography) project implemented by the Indonesian Ministry of Marine Affairs and Fisheries. The initial hydrographic conditions as well as open-boundary conditions are derived from the operational global ocean forecasting system at 1/4° operated by Mercator Océan. Atmospheric forcing fields (3-hourly ECMWF (European Centre for Medium-Range Weather Forecast) analyses) are used to force the regional model. INDO12 is also forced by tidal currents and elevations, and by the inverse barometer effect. The turbulent mixing induced by internal tides is taken into account through a specific parameterisation. In this study we evaluate the model skill through comparisons with various data sets including outputs of the parent model, climatologies, in situ temperature and salinity measurements, and satellite data. The biogeochemical model results assessment is presented in a companion paper (Gutknecht et al., 2015). The simulated and altimeter-derived Eddy Kinetic Energy fields display similar patterns and confirm that tides are a dominant forcing in the area. The volume transport of the Indonesian throughflow (ITF) is in good agreement with the INSTANT estimates while the transport through Luzon Strait is, on average, westward but probably too weak. Compared to satellite data, surface salinity and temperature fields display marked biases in the South China Sea. Significant water mass transformation occurs along the main routes of the ITF and compares well with observations. Vertical mixing is able to modify the South and North Pacific subtropical water-salinity maximum as seen in T-S diagrams. In spite of a few weaknesses, INDO12 proves to be able to provide a very realistic simulation of the ocean circulation and water mass

  4. Parental involvement

    Directory of Open Access Journals (Sweden)

    Ezra S Simon

    2005-01-01

    Full Text Available Parent-Teacher Associations and other community groups can play a significant role in helping to establish and run refugee schools; their involvement can also help refugee adults adjust to their changed circumstances.

  5. Analysis method for the search for neutrinoless double beta decay in the NEMO3 experiment: study of the background and first results; Methode d'analyse pour la recherche de la double desintegration {beta} sans emission de neutrinos dans l'experience NEMO3. Etude du bruit de fond et premiers resultats

    Energy Technology Data Exchange (ETDEWEB)

    Etienvre, A I

    2003-04-15

    The NEMO3 detector, installed in the Frejus Underground Laboratory, is dedicated to the study of neutrinoless double beta decay: the observation of this process would sign the massive and Majorana nature of neutrino. The experiment consists in very thin central source foils (the total mass is equal to 10 kg), a tracking detector made of drift cells operating in Geiger mode, a calorimeter made of plastic scintillators associated to photomultipliers, a coil producing a 30 gauss magnetic field and two shields, dedicated to the reduction of the {gamma}-ray and neutron fluxes. In the first part, I describe the implications of several mechanisms, related to trilinear R-parity violation, on double beta decay. The second part is dedicated to a detailed study of the tracking detector of the experiment: after a description of the different working tests, I present the determination of the characteristics of the tracking reconstruction (transverse and longitudinal resolution, by Geiger cell and precision on vertex determination, charge recognition). The last part corresponds to the analysis of the data taken by the experiment. On the one hand, an upper limit on the Tl{sup 208} activity of the sources has been determined: it is lower than 68 mBq/kg, at 90% of confidence level. On the other hand, I have developed and tested on these data a method in order to analyse the neutrinoless double beta decay signal; this method is based on a maximum of likelihood using all the available information. Using this method, I could determine a first and very preliminary upper limit on the effective mass of the neutrino. (author)

  6. Analysis method for the search for neutrinoless double beta decay in the NEMO3 experiment: study of the background and first results; Methode d'analyse pour la recherche de la double desintegration {beta} sans emission de neutrinos dans l'experience NEMO3. Etude du bruit de fond et premiers resultats

    Energy Technology Data Exchange (ETDEWEB)

    Etienvre, A.I

    2003-04-15

    The NEMO3 detector, installed in the Frejus Underground Laboratory, is dedicated to the study of neutrinoless double beta decay: the observation of this process would sign the massive and Majorana nature of neutrino. The experiment consists in very thin central source foils (the total mass is equal to 10 kg), a tracking detector made of drift cells operating in Geiger mode, a calorimeter made of plastic scintillators associated to photomultipliers, a coil producing a 30 gauss magnetic field and two shields, dedicated to the reduction of the {gamma}-ray and neutron fluxes. In the first part, I describe the implications of several mechanisms, related to trilinear R-parity violation, on double beta decay. The second part is dedicated to a detailed study of the tracking detector of the experiment: after a description of the different working tests, I present the determination of the characteristics of the tracking reconstruction (transverse and longitudinal resolution, by Geiger cell and precision on vertex determination, charge recognition). The last part corresponds to the analysis of the data taken by the experiment. On the one hand, an upper limit on the Tl{sup 208} activity of the sources has been determined: it is lower than 68 mBq/kg, at 90% of confidence level. On the other hand, I have developed and tested on these data a method in order to analyse the neutrinoless double beta decay signal; this method is based on a maximum of likelihood using all the available information. Using this method, I could determine a first and very preliminary upper limit on the effective mass of the neutrino. (author)

  7. Involving women.

    Science.gov (United States)

    Agbo, J

    1994-01-01

    I am a primary health care (PHC) coordinator working with the May Day Rural project, a local NGO involved in integrated approaches and programs with rural communities in the Ga District of the Greater-Accra region in Ghana. When we talk about the community development approach we must first and foremost recognize that we are talking about women, because in the developing world frequent childbirths mean that her burden of mortality is higher than a man's; her workload is extremely heavy--whether in gardening, farming, other household duties, caring for the sick, or the rearing of children; she has a key role in PHC and community development, because men are always looking for greener pastures elsewhere, leaving the women behind. Women's concerns are critical in most health care projects and women and children are their main beneficiaries. Why not include women in the management team, project design, implementation and evaluation processes? That is what the May Day Rural project is practicing, encouraging women's participation and creating a relationship of trust. full text

  8. Toward variational assimilation of SARAL/Altika altimeter data in a North Atlantic circulation model at eddy-permitting resolution: assessment of a NEMO-based 4D-VAR system

    Science.gov (United States)

    Bouttier, Pierre-Antoine; Brankart, Jean-Michel; Candille, Guillem; Vidard, Arthur; Blayo, Eric; Verron, Jacques; Brasseur, Pierre

    2015-04-01

    In this project, the response of a variational data assimilation system based on NEMO and its linear tangent and adjoint model is investigated using a 4DVAR algorithm into a North-Atlantic model at eddy-permitting resolution. The assimilated data consist of Jason-2 and SARAL/AltiKA dataset collected during the 2013-2014 period. The main objective is to explore the robustness of the 4DVAR algorithm in the context of a realistic turbulent oceanic circulation at mid-latitude constrained by multi-satellite altimetry missions. This work relies on two previous studies. First, a study with similar objectives was performed based on academic double-gyre turbulent model and synthetic SARAL/AltiKA data, using the same DA experimental framework. Its main goal was to investigate the impact of turbulence on variational DA methods performance. The comparison with this previous work will bring to light the methodological and physical issues encountered by variational DA algorithms in a realistic context at similar, eddy-permitting spatial resolution. We also have demonstrated how a dataset mimicking future SWOT observations improves 4DVAR incremental performances at eddy-permitting resolution. Then, in the context of the OSTST and FP7 SANGOMA projects, an ensemble DA experiment based on the same model and observational datasets has been realized (see poster by Brasseur et al.). This work offers the opportunity to compare efficiency, pros and cons of both DA methods in the context of KA-band altimetric data, at spatial resolution commonly used today for research and operational applications. In this poster we will present the validation plan proposed to evaluate the skill of variational experiment vs. ensemble assimilation experiments covering the same period using independent observations (e.g. from Cryosat-2 mission).

  9. Phylogenetic and Physiological Diversity of Subseafloor Microbial Communities at Axial Seamount, Juan de Fuca Ridge: Summary of Results From the New Millenium Observatory (NeMO), 1998-2004

    Science.gov (United States)

    Baross, J. A.; Huber, J. A.; Mehta, M. P.; Opatkiewicz, A.; Bolton, S. A.; Butterfield, D. A.; Sogin, M. L.; Embley, R. W.

    2005-12-01

    Axial Seamount (45 ° 58' N; 130 ° 00' W) is an active submarine volcano located on the Juan de Fuca Ridge, approximately 300 miles off the coast of Oregon. Lying at the intersection of a seamount chain and a spreading axis, Axial is a unique study site from both the geological and biological perspective. In January of 1998, Axial experienced a week-long series of earthquakes, and subsequent water column and seafloor observations on the southeast portion of the caldera found temperature and chemical anomalies, extensive new seafloor lava flows, large "snow blower" type vents, and other characteristics commonly associated with diking-eruptive events. Due to its high activity and close proximity to shore, Axial was chosen as a site for a multi-year observatory (New Millenium Observatory, NeMO) to document changes and interactions between geology, chemistry, and biology on the mid-ocean ridge system. From 1998 through 2004, we extensively sampled diffuse vents at Axial Seamount to determine the physiological and phylogenetic diversity of subseafloor microbial communities and their relationship to the geochemical environment. Here we present a summary of those studies, including molecular-based phylogenetic surveys of bacteria, archaea, and potential nitrogen-fixing organisms, culturing results of thermophiles and hyperthermophiles from over 20 sites, and the distribution of one particular group of hyperthermophiles at diffuse vents throughout the caldera and how that distribution may be linked to the geochemical habitat. Results indicate that Axial supports a diverse subseafloor microbial community, including hydrogen and sulfur oxidizers, hyperthermophilic methane producers and heterotrophs, and many organisms with the potential to fix nitrogen. In addition, we find that the species composition of the microbial community changes in response to changes in the physical and chemical conditions at each vent site. The extent of seawater mixing with hydrothermal fluids

  10. Who and What Does Involvement Involve?

    DEFF Research Database (Denmark)

    Hansen, Jeppe Oute; Petersen, Anders; Huniche, Lotte

    2015-01-01

    This article gives an account of aspects of a multi-sited field study of involvement of relatives in Danish psychiatry. By following metaphors of involvement across three sites of the psychiatric systema family site, a clinical site and a policy sitethe first author (J.O.) investigated how...... theoretical perspective laid out by Ernesto Laclau and Chantal Mouffe, the aim of this study is to show how the dominant discourse about involvement at the political and clinical sites is constituted by understandings of mentally ill individuals and by political objectives of involvement. The analysis...... the responsibility toward the mental health of the ill individual as well as toward the psychological milieu of the family....

  11. Eye Involvement in TSC

    Science.gov (United States)

    ... eye involvement. Nonretinal and Retinal Eye Findings Facial angiofibromas may involve the eyelids of individuals with TSC, ... the hamartomas have many blood vessels (as are angiofibromas of the skin). Less than half of the ...

  12. Organizing Patient Involvement

    DEFF Research Database (Denmark)

    Brehm Johansen, Mette

    hospitals. During the last 25 years, patient involvement and quality improvement have become connected in Danish healthcare policy. However, the ideal of involving patients in quality improvement is described in very general terms and with only few specific expectations of how it is to be carried out...... in practice, as I show in the thesis. In the patient involvement literature, the difficulties of getting patient involvement in quality improvement to have in an impact on the planning and development of healthcare services is, for example, ascribed to conceptual vagueness of patient involvement, differences...... in perspectives, values and understandings between patients and healthcare professionals, or the lack of managerial attention and prioritization....

  13. JOINT INVOLVEMENT IN SYPHILIS

    Directory of Open Access Journals (Sweden)

    T. I. Zlobina

    2016-01-01

    Full Text Available Joint involvement in syphilis has been considered as casuistry in recent years. At the same time, the high incidence of primary syphilis and the notified cases of late neurosyphilis may suggest that joint involvement in this disease is by no means always verified. Traditionally there are two forms of syphilitic arthritis: primary synovial (involving the articular membranes and sac and primary bone (involving the articular bones and cartilages ones. The paper describes the authors' clinical case of the primary bone form of articular syphilis in a 34-year-old man. 

  14. Parent Involvement Handbook.

    Science.gov (United States)

    Caplan, Arna

    This handbook on parent involvement, designed to be used with preschool programs, was developed by the Jefferson County Public Schools in Lakewood, Colorado. Included are: (1) a general statement about parent involvement in an early childhood program, (2) a description of the Jefferson County Early Childhood Program, (3) a description of the…

  15. The Involved Ostrich

    DEFF Research Database (Denmark)

    Davies, Andrea; Dobscha, Susan; Geiger, Susi

    2008-01-01

    that the transition into parenthood can be difficult for men due to their lack of a physical connection to the pregnancy, a perception that the baby industry is not designed for them, the continuance of male stereotypes in the media, and also the time available to men to become involved in consumption activities......-natal data. Data revealed that men, according to their partner’s perceptions, used consumption as a virtual umbilical cord, although levels of consumption involvement varied from co-involvement for most purchases, to limited involvement, and/or involvement for ‘large’ items, particularly travel systems...... and technical items. This research also revealed that men partook in highly masculinized forms of “nesting,” and in general shunned pregnancy book reading; although some did engage in “research” activities such as searching the internet for product safety information. We conclude from this study...

  16. IDEA and Family Involvement

    Directory of Open Access Journals (Sweden)

    Mehmet Emin Öztürk

    2017-01-01

    Full Text Available Individuals with Disabilities Education Act (IDEA gives many rights to parents with special needs in terms of involvement and participation. Given the importance of family involvement in the special education process, and federal legislation that increasingly mandated and supported such involvement over time, considerable research has focused on the multiple ways that relationships between schools and families in the special education decision making process have played out. Educational professionals should create a positive climate for CLD families so that they feel more comfortable and therefore are able to participate more authentically and meaningfully.

  17. Parental Involvement in Education.

    Science.gov (United States)

    Blackstone, Tessa

    1979-01-01

    Arguments in favor of increased parental involvement, particularly in nursery education, are presented. Opposition to participation from parents and teachers is discussed and specific areas in which cooperation might be possible are suggested along with different levels of participation. (JMF)

  18. Cardiovascular involvement in myositis

    DEFF Research Database (Denmark)

    Diederichsen, Louise P

    2017-01-01

    PURPOSE OF REVIEW: The purpose of this review is to provide an update on cardiovascular involvement in idiopathic inflammatory myopathy (IIM). Studies from the past 18 months are identified and reviewed. Finally, the clinical impact of these findings is discussed. RECENT FINDINGS: Epidemiological...... on cardiac magnetic resonance (CMR) imaging suggests that CMR should be considered as a potentially viable diagnostic tool to evaluate the possibility of silent myocardial inflammation in IIM with normal routine noninvasive evaluation. SUMMARY: Updated literature on cardiovascular involvement in IIM has...... identified an increased risk for subclinical and clinical cardiovascular disease in these rare inflammatory muscle diseases....

  19. Who Involves Whom?

    Science.gov (United States)

    Ward, Clifford

    1979-01-01

    The author reviews the development of a parents' group at the Bradford Grange School (Manchester, United Kingdom) for ESN (educationally subnormal) children. Problems with the initial parents' group are pointed out, successful approaches are considered, and the importance of parent involvement is stressed. (SBH)

  20. PATTERNS AND FACTORS INVOLVED

    African Journals Online (AJOL)

    Between 1*' of July 1996 and 30'h of June 2000 a total of 3583 patients were registered at the accident and emergency unit of Nnamdi. Azikiwe ... The case files of these were reviewed with a view to ascertaining the causes and factors involved in the deaths of these patients. The .... H.I.V/AIDS related complications 23 6.8.

  1. Microorganisms involved in MIC

    Energy Technology Data Exchange (ETDEWEB)

    Sorensen, K. [Danish Technological Institute (Denmark)

    2011-07-01

    Microbiologically influenced corrosion (MIC) is a widespread problem that is difficult to detect and assess because of its complex mechanism. This paper presents the involvement of microorganisms in MIC. Some of the mechanisms that cause MIC include hydrogen consumption, production of acids, anode-cathode formation and electron shuttling. A classic bio-corrosive microorganism in the oil and gas industry is sulphate-reducing prokaryotes (SRP). Methanogens also increase corrosion rates in metals. Some of the phylogenetic orders detected while studying SRP and methanogens are archaeoglobales, clostridiales, methanosarcinales and methanothermococcus. There were some implications, such as growth of SRP not being correlated with growth of methanogens; methanogens were included in MIC risk assessment. A few examples are used to display how microorganisms are involved in topside corrosion and microbial community in producing wells. From the study, it can be concluded that, MIC risk assessment includes system data and empirical knowledge of the distribution and number of microorganisms in the system.

  2. Involved Node Radiation Therapy

    DEFF Research Database (Denmark)

    Maraldo, Maja V; Aznar, Marianne C; Vogelius, Ivan R

    2012-01-01

    PURPOSE: The involved node radiation therapy (INRT) strategy was introduced for patients with Hodgkin lymphoma (HL) to reduce the risk of late effects. With INRT, only the originally involved lymph nodes are irradiated. We present treatment outcome in a retrospective analysis using this strategy...... to 36 Gy). Patients attended regular follow-up visits until 5 years after therapy. RESULTS: The 4-year freedom from disease progression was 96.4% (95% confidence interval: 92.4%-100.4%), median follow-up of 50 months (range: 4-71 months). Three relapses occurred: 2 within the previous radiation field......, and 1 in a previously uninvolved region. The 4-year overall survival was 94% (95% confidence interval: 88.8%-99.1%), median follow-up of 58 months (range: 4-91 months). Early radiation therapy toxicity was limited to grade 1 (23.4%) and grade 2 (13.8%). During follow-up, 8 patients died, none from HL, 7...

  3. Reactors also involve people

    International Nuclear Information System (INIS)

    Hurt, H.B.

    1975-01-01

    As the nuclear industry develops it is to be hoped that high quality occupational health programs will evolve along with other sound operational procedures and practices. The immediate involvement of occupational health personnel may well afford a safety factor which will minimize the likelihood of either the selection of personnel not adequate for the full responsibilities of their work or the continuation in responsible positions of personnel who develop handicaps of either a physical or mental nature

  4. Involvement through photography.

    Science.gov (United States)

    Takai, J

    2016-12-01

    As a photographer living in Tokyo, I have been visiting Suetsugi village regularly to take photographs and show the printed photographs to the residents. What is the role of photography? What does it mean to be involved in the life of Suetsugi through photography? This article discusses some of the answers to these questions 5 years after the accident at Fukushima Daiichi nuclear power plant.

  5. Getting involved in research.

    Science.gov (United States)

    Banner, Davina; Grant, Lyle G

    2011-01-01

    The need for quality nursing research to promote evidence-based practice and optimize patient care is well recognized. This is particularly pertinent in cardiovascular nursing, where cardiovascular disease continues to be the leading cause of morbidity and mortality worldwide (World Health Organization, 2007). Across the spectrum of academic, clinical, and health care administration nursing roles, research remains fundamental to bridging theory, practice, and education (LoBiondo-Wood, Haber, Cameron, & Singh, 2009). Despite recognition of the importance of nursing research, the gap between research and practice continues to be an ongoing issue (Funk, Tornquist, & Champagne, 1995; Pettengill, Gillies, & Clark, 1994; Rizzuto, Bostrom, Suterm, & Chenitz, 1994; Rolfe, 1998). Nurses are appropriately situated to contribute to research that improves clinical outcomes and health service delivery. However, the majority of nurses in clinical practice do not have a significant research component structured into their nursing role. In this research column, the authors outline the importance of nurses being engaged in research and present some different levels of involvement that nurses may assume. A continuum of nursing research involvement includes asking researchable questions, being a savvy consumer of research evidence, finding your own level of research involvement, and aspiring to lead.

  6. Involvement Without Participation?

    DEFF Research Database (Denmark)

    Olsén, Peter

    2012-01-01

    The article presents a case study of a knowledge-intensive company that launched a 2-year project to improve their psychosocial working environment. All parties agreed on the project, and the methods used aimed to promote the involvement of the employees. Surprisingly, the psychosocial working...... environment did not improve; on the contrary, it deteriorated. The article highlights cultural and structural obstacles to the process, including an inadequate understanding of organisational learning and a narrow focus on market and competition. The endeavours did not consistently increase delegation...

  7. Involvement in Physical Activity

    Directory of Open Access Journals (Sweden)

    James Gavin

    2013-04-01

    Full Text Available A total of 1,096 adolescents participated in 123 focus groups regarding the perceived outcomes of their involvement in sports and physical activity (PA. The groups, segmented by grade level, sex, and school types, were conducted in both public and private high schools in Montreal, Quebec. We sought to understand, through the participants’ own words, their perception of the outcome matrix of involvement in sports and PA. Focus group questions emphasized changes that adolescents associated with such engagement. In particular, participants were asked how sports and PA might influence behaviors, emotional states, personal characteristics, and other outcomes. Twelve themes were identified in the responses: Positive Health and Physical Changes (18.5%, Activity-Related Positive Emotions (15.6%, and Personal Learning (11.3% were most prevalent in the discussions. A cluster of deeper personal changes thematically described as Self-Identity, Autonomy, and Positive Character Development accounted for another 16.5% of the responses. Relatively few commentaries emphasized negative effects (7.1%. Converting the proportions of qualitative data into a quantitative index allowed us to analyze potential differences in emphasis according to sex, age, and school type. Though a few significant findings emerged, the larger pattern was of a uniform perceptual map across the variables for this adolescent sample. Implications drawn from this investigation highlight the need to clearly articulate concrete pathways to positive nonphysical changes (e.g., mood states, autonomy, positive character development from engagements in sports and PA.

  8. Public interest group involvement

    International Nuclear Information System (INIS)

    Shelley, P.

    1986-01-01

    Including public interest groups in the siting process for nuclear waste disposal facilities is of great importance. Controversial sitings often result in litigation, but involving public interest groups early in the process will lessen the change of this. They act as surrogates for the general public and should be considered as members of the team. It is important to remember though, that all public interest groups are different. In choosing public panels such as public advisory committees, members should not be chosen on the basis of some quota. Opposition groups should not be excluded. Also, it is important to put the right person in charge of the committee. The goal of public involvement is to identify the conflicts. This must be done during the decision process, because conflicts must be known before they can be eliminated. Regarding litigation, it is important to ease through and around legal battles. If the siting process has integrity and a good faith effort has been shown, the court should uphold the effort. In addition, it is important to be negotiable and to eliminate shortcuts

  9. [Father involvement in childbirth].

    Science.gov (United States)

    Villalón, H; Toro, R; Riesco, I; Pinto, M; Silva, C

    2014-10-01

    Recent initiatives have promoted the participation of fathers in the early care of their children. To assess the results of a program to encourage parental involvement in childbirth. Parents of healthy term newborns were randomly allocated to participate either in the birth experience or control. The protocol included: to dry the skin, umbilical cord cutting off, weight, height, and finally give him/her to the mother for the skin-to-skin contact. Heart rate (HR), respiratory (RR) and temperature were evaluated one hour later. In the first outpatient clinic assessment, mothers completed a questionnaire. 127 fathers participated either in the birth experience or control. 62 followed the protocol and 65 the control. Both newborn groups were comparable. Also were fathers in age, education and rurality; mothers in primiparity. Significant differences: night care (37/62, 10/65 59.6% vs 15.4%, pfathers at birth, even belonging to a discouraging socio cultural environment.

  10. Fostering employee involvement.

    Science.gov (United States)

    Beecher, G P

    1997-11-01

    Every year, the ODA's Economics of Practice Committee, with the help of an independent consulting firm, carries out the Cost of Practice Monitor which tracks the various costs of running a dental practice in Ontario. This article is the result of a joint ODA-Arthur Andersen initiative to provide members with detailed information from the Monitor. Over the next year, there will be a series of articles published under the heading "Best practises for Ontario's Dental Practices." The article featured in this issue focuses on wage expenses in dental practices and how to foster employee involvement as a means of addressing cost-productivity issues. Furthermore, information relating to wage expenses may be used by practitioners to benchmark their practice against the average Ontario dental practice. Appendix C was developed for this purpose. Through benchmarking, the practitioner may gain insight into ways of evaluating their practice and in addressing issues that could improve the management of the practice. For a long time, concepts of best business practises were applied only to manufacturing organizations or large multi-national corporations but experience has demonstrated that these activities are universal to all organizations, including service companies, schools, government and not-for-profit organizations.

  11. Influence of Involvement in Sports on Students' Involvement in ...

    African Journals Online (AJOL)

    This study was carried out to establish whether students' involvement in sports activities affected their involvement in academic activities. Data were collected using a self-administered questionnaire and analysed using percentages and means. Spearman's correlation coefficient was used to test the hypotheses that guided ...

  12. Maternal Involvement and Academic Achievement.

    Science.gov (United States)

    Lopez, Linda C.; Holmes, William M.

    The potential impact of several maternal involvement behaviors on teachers' ratings of children's academic skills was examined through statistical analyses. Data, based on mothers' responses to selected questions concerning maternal involvement and on teachers' ratings on the Classroom Behavior Inventory, were obtained for 115 kindergarten…

  13. Parental Involvement and Academic Achievement

    Science.gov (United States)

    Goodwin, Sarah Christine

    2015-01-01

    This research study examined the correlation between student achievement and parent's perceptions of their involvement in their child's schooling. Parent participants completed the Parent Involvement Project Parent Questionnaire. Results slightly indicated parents of students with higher level of achievement perceived less demand or invitations…

  14. Esophageal involvement in eosinophilic gastroenteritis

    Energy Technology Data Exchange (ETDEWEB)

    Matzinger, M A; Daneman, A

    1983-02-01

    The radiologic appearance of esophageal involvement due to eosinophilic gastroenteritis in a 15-year-old boy is presented. The lower two thirds of the esophagus was narrowed and the peristalsis diminished. The mucosa appeared smooth. This is the fourth reported case of esophageal involvement in eosinophilic gastroenteritis.

  15. Religion, Convention, and Paternal Involvement.

    Science.gov (United States)

    Wilcox, W. Bradford

    2002-01-01

    Examines the influence of religious affiliation and attendance on the involvement of residential fathers in one-on-one activities, dinner with their families, and youth activities and found religious effects for each of these three measures. The study indicates that religion is related to paternal involvement in all three areas that were examined.…

  16. Ego involvement increases doping likelihood.

    Science.gov (United States)

    Ring, Christopher; Kavussanu, Maria

    2018-08-01

    Achievement goal theory provides a framework to help understand how individuals behave in achievement contexts, such as sport. Evidence concerning the role of motivation in the decision to use banned performance enhancing substances (i.e., doping) is equivocal on this issue. The extant literature shows that dispositional goal orientation has been weakly and inconsistently associated with doping intention and use. It is possible that goal involvement, which describes the situational motivational state, is a stronger determinant of doping intention. Accordingly, the current study used an experimental design to examine the effects of goal involvement, manipulated using direct instructions and reflective writing, on doping likelihood in hypothetical situations in college athletes. The ego-involving goal increased doping likelihood compared to no goal and a task-involving goal. The present findings provide the first evidence that ego involvement can sway the decision to use doping to improve athletic performance.

  17. GOVERNMENT INVOLVEMENT IN CONSUMPTION BEHAVIOUR

    Directory of Open Access Journals (Sweden)

    CRISTINA ZAMFIR

    2010-01-01

    Full Text Available In this article, we will follow the involvement that the government has,through its expenses, on the consumption behavior. The involvement that the government has inthe consumption behavior is made through fees and taxes that are applied on income. Fees andtaxes are applied to the different forms of income but in this article we will be focused only onthe influence of them on wages. In order to analyze the involvement of government expenses onconsumption behavior an utility model will be used.

  18. Black parental involvement in education

    African Journals Online (AJOL)

    Erna Kinsey

    The South African Schools Act of 1996 (SASA) provides formal power in education to parents as well as communities. ... Review of selected studies on parental involvement in ..... Anna, a Grade 11 teacher, summed up the feelings of the.

  19. Renal involvement in behcet's disease

    International Nuclear Information System (INIS)

    Ardalan, Mohammad Reza; Noshad, Hamid; Sadreddini, Shahram; Ebrahimi, Aliasghar; Molaeefard, Mahsheed; Somi, Mohammad Hossein; Shoja, Mohammadali Mohajel

    2009-01-01

    There are conflicting reports about the renal involvement in Behcet's disease (BD). In this study we aimed to study the frequency and type of renal involvement in a group of patients with BD in Azerbaijan province that is one of the prevalent areas of BD in Iran. All cases of BD were prospectively followed between June 2004 and January 2007, and evaluated for renal dys-function (serum creatinine > 1.7 mg/dL), glomerular hematuria and proteinuria. Those patients with proteinuria > 500 mg/day and serum creatinine level > 2 mg/dL, underwent renal biopsy. From a total number of 100 patients, six patients (6%) had obvious renal involvements. Four patients had glomerular hematuria and proteinuria. Renal biopsy in two of them revealed measangial proliferative glumerulonephritis with IgA deposit in one of them and membranoproliferative glumerolonephritis in another one. Two remaining patients had serum creatinine > 2 mg/dL without any hematuria or proteinuria. Serologic study for viral agents and collagen vascular disease were negative in all patients with renal involvements. In conclusion, renal involvement in BD is not infrequent, although in most cases it is mild in nature and may be missed. (author)

  20. Respiratory muscle involvement in sarcoidosis.

    Science.gov (United States)

    Schreiber, Tina; Windisch, Wolfram

    2018-07-01

    In sarcoidosis, muscle involvement is common, but mostly asymptomatic. Currently, little is known about respiratory muscle and diaphragm involvement and function in patients with sarcoidosis. Reduced inspiratory muscle strength and/or a reduced diaphragm function may contribute to exertional dyspnea, fatigue and reduced health-related quality of life. Previous studies using volitional and non-volitional tests demonstrated a reduced inspiratory muscle strength in sarcoidosis compared to control subjects, and also showed that respiratory muscle function may even be significantly impaired in a subset of patients. Areas covered: This review examines the evidence on respiratory muscle involvement and its implications in sarcoidosis with emphasis on pathogenesis, diagnosis and treatment of respiratory muscle dysfunction. The presented evidence was identified by a literature search performed in PubMed and Medline for articles about respiratory and skeletal muscle function in sarcoidosis through to January 2018. Expert commentary: Respiratory muscle involvement in sarcoidosis is an underdiagnosed condition, which may have an important impact on dyspnea and health-related quality of life. Further studies are needed to understand the etiology, pathogenesis and extent of respiratory muscle involvement in sarcoidosis.

  1. Inclusive Briefing and User Involvement

    DEFF Research Database (Denmark)

    Jensen, Per Anker

    2011-01-01

    Briefing is not just about specifying needs as requirements but also about evaluating how well design proposals fulfil needs and aspirations. Furthermore, briefing is not only about building design. Briefing starts at the preproject stage to create a basis for the project decision and can include...... by top management. The article describes the briefing processes and the methods for user involvement, identifies problem areas and points out possible improvements. The author was actively involved in the project as deputy project director, with responsibility for the briefing process, and is now...... includes a literature study on briefing and user involvement in building projects, and presents a case study of a major building project of a new headquarters and media centre for the Danish Broadcasting Corporation in Copenhagen. The building project was actively used as part of a corporate change process...

  2. Drug involvement in fatal overdoses

    Directory of Open Access Journals (Sweden)

    Christopher J. Ruhm

    2017-12-01

    Full Text Available Death certificate data from the Multiple Cause of Death (MCOD files were analyzed to better understand the drug categories most responsible for the increase in fatal overdoses occurring between 1999 and 2014. Statistical adjustment methods were used to account for the understatement in reported drug involvement occurring because death certificates frequently do not specify which drugs were involved in the deaths. The frequency of combination drug use introduced additional uncertainty and so a distinction was made between any versus exclusive drug involvement. Many results were sensitive to the starting and ending years chosen for examination. Opioid analgesics played a major role in the increased drug deaths for analysis windows starting in 1999 but other drugs, particularly heroin, became more significant for recent time periods. Combination drug use was important for all time periods and needs to be accounted for when designing policies to slow or reverse the increase in overdose deaths.

  3. User involvement in care work

    DEFF Research Database (Denmark)

    Dybbroe, Betina; Kamp, Annette

    In recent years user involvement has become a paradigm for transforming the health and social care sector. This development–also labelled empowerment, co-creation, partnership, patient-centeredness - is seen as a means to reform organizations in ways that enhance quality, economic cost effectiven...... forms of professionalism, and imply tensions in health and social care work.......In recent years user involvement has become a paradigm for transforming the health and social care sector. This development–also labelled empowerment, co-creation, partnership, patient-centeredness - is seen as a means to reform organizations in ways that enhance quality, economic cost...... addressed the way this paradigm affects the users, in specific sectors. However user involvement also affects working life. It may imply change and redistribution of tasks and identities between users and professionals, and may also transform the relations of care. In this paper we explore the possible...

  4. User interface and patient involvement.

    Science.gov (United States)

    Andreassen, Hege Kristin; Lundvoll Nilsen, Line

    2013-01-01

    Increased patient involvement is a goal in contemporary health care, and of importance to the development of patient oriented ICT. In this paper we discuss how the design of patient-user interfaces can affect patient involvement. Our discussion is based on 12 semi-structured interviews with patient users of a web-based solution for patient--doctor communication piloted in Norway. We argue ICT solutions offering a choice of user interfaces on the patient side are preferable to ensure individual accommodation and a high degree of patient involvement. When introducing web-based tools for patient--health professional communication a free-text option should be provided to the patient users.

  5. Strategy Innovation with Employee Involvement

    DEFF Research Database (Denmark)

    Friis, Ole Uhrskov; Koch, Christian

    2015-01-01

    The purpose of this article is to investigate how employees can be involved in strategy innovation processes and how new strategy practices (new tools and procedures) are used to change strategy praxis in order to sustain value creation. In the strategizing actions, we found that even...... if the managers still dominate, some processes of direct involvement of employees occur, in particular when employees are asked to supplement overall strategic goals and when they directly shape several sub-strategies. Strategy practices found include strategy planning, an open space workshop and organised...... strategy projects. Especially the latter two are important in facilitating the employee involvement. The case, however, also exhibits enterprise-situated praxises related to unplanned events, like the mitigation of taboos....

  6. Vertebral osteomyelitis without disc involvement

    Energy Technology Data Exchange (ETDEWEB)

    Kamani, I.; Syed, I.; Saifuddin, A. E-mail: asaifuddin@aol.com; Green, R.; MacSweeney, F

    2004-10-01

    Vertebral osteomyelitis is most commonly due to pyogenic or granulomatous infection and typically results in the combined involvement of the intervertebral disc and adjacent vertebral bodies. Non-infective causes include the related conditions of chronic recurrent multifocal osteomyelitis (CRMO) and SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome. Occasionally, these conditions may present purely within the vertebral body, resulting in various combinations of vertebral marrow oedema and sclerosis, destructive lesions of the vertebral body and pathological vertebral collapse, thus mimicking neoplastic disease. This review illustrates the imaging features of vertebral osteomyelitis without disc involvement, with emphasis on magnetic resonance imaging (MRI) findings.

  7. Multisystem involvement in neuromyelitis optica

    Directory of Open Access Journals (Sweden)

    Megan M Langille

    2015-01-01

    Full Text Available We describe a case of pediatric neuromyelitis optica (NMO with muscle and lung involvement in addition to central nervous system disease. Our patient initially presented with features of area postrema syndrome, then subsequently with optic neuritis. The patient also had recurrent hyperCKemia that responded to corticosteroids. Finally, axillary and hilar adenopathy with pulmonary consolidation were noted as well and responded to immunomodulation. Our case highlights multisystem involvement in NMO including non-infectious pulmonary findings which have not been described in the pediatric population previously.

  8. Guidance on accidents involving radioactivity

    International Nuclear Information System (INIS)

    1989-01-01

    This annex contains advice to Health Authorities on their response to accidents involving radioactivity. The guidance is in six parts:-(1) planning the response required to nuclear accidents overseas, (2) planning the response required to UK nuclear accidents a) emergency plans for nuclear installations b) nuclear powered satellites, (3) the handling of casualties contaminated with radioactive substances, (4) background information for dealing with queries from the public in the event of an accident, (5) the national arrangements for incident involving radioactivity (NAIR), (6) administrative arrangements. (author)

  9. Involving Employees in Strategy innovation

    DEFF Research Database (Denmark)

    Friis, Ole Uhrskov; Koch, Christian

    2011-01-01

    Strategy as a practice and continuous innovation approaches are combined to conceptualise dilemmas of short versus long term and to analyse a case of employee participation as a particular example of strategy innovation. The case is a medium size textile company developing its strategy involving ...... and Balanced Score Card consultancy, an ‘open space’ workshop and organized strategy projects. Especially the latter two are important in facilitating the employee involvement. The case however also exhibit enterprise situated praxis’s like mitigation of taboos....

  10. Extrapulmonary involvement in pediatric tuberculosis.

    Science.gov (United States)

    Kritsaneepaiboon, Supika; Andres, Mariaem M; Tatco, Vincent R; Lim, Cielo Consuelo Q; Concepcion, Nathan David P

    2017-09-01

    Tuberculosis in childhood is clinically challenging, but it is a preventable and treatable disease. Risk factors depend on age and immunity status. The most common form of pediatric tuberculosis is pulmonary disease, which comprises more than half of the cases. Other forms make up the extrapulmonary tuberculosis that involves infection of the lymph nodes, central nervous system, gastrointestinal system, hepatobiliary tree, and renal and musculoskeletal systems. Knowledge of the imaging characteristics of pediatric tuberculosis provides clues to diagnosis. This article aims to review the imaging characteristics of common sites for extrapulmonary tuberculous involvement in children.

  11. Putaminal involvement in Rasmussen encephalitis

    Energy Technology Data Exchange (ETDEWEB)

    Rajesh, Bhagavatheeswaran; Ashalatha, Radhakrishnan [Sree Chitra Tirunal Institute for Medical Sciences and Technology, Department of Neurology, Trivandrum, Kerala (India); Kesavadas, Chandrasekharan; Thomas, Bejoy [Sree Chitra Tirunal Institute for Medical Sciences and Technology, Department of Imaging Sciences and Interventional Radiology, Trivandrum, Kerala (India)

    2006-08-15

    Rasmussen encephalitis (RE) is a rare devastating disease of childhood causing progressive neurological deficits and intractable seizures, typically affecting one hemisphere. Characteristic MRI features include progressive unihemispheric focal cortical atrophy and grey- or white-matter high-signal changes and basal ganglion involvement, particularly of the caudate nucleus. To analyse the pattern of involvement of different brain structures in a series of patients with RE and to attempt clinical correlation. We reviewed the medical records and neuroimaging data of 12 patients diagnosed with RE satisfying the European Consensus Statement diagnostic criteria. The disease manifested as seizures in all patients and was refractory; epilepsia partialis continua was a notable feature (nine patients). Hemiparesis of varying grades was noted in all but one patient; none had extrapyramidal signs. Neuroimaging showed cortical involvement in the insular/periinsular regions in 11 patients. Caudate atrophy was noted in ten patients. Putaminal atrophy was seen in nine patients, six of whom had additional hyperintense signal changes. Our study highlights frequent putaminal atrophy and signal changes in RE, which suggests a more extensive basal ganglion involvement than emphasized previously. Recognition of putaminal changes may be a useful additional tool in the radiological diagnosis of RE. (orig.)

  12. Managing Parent Involvement during Crisis

    Science.gov (United States)

    Merriman, Lynette S.

    2008-01-01

    In the wake of 9/11, Hurricane Katrina, and the Virginia Tech shooting tragedy, it is no surprise that concern for students' safety is the primary reason attributed to parents' increased involvement. Parents and university administrators share in their commitment to student safety. However, college and university staff who assume responsibility…

  13. Patient involvement in hospital architecture

    DEFF Research Database (Denmark)

    Herriott, Richard

    2017-01-01

    the structure of the design process, identification and ranking of stakeholders, the methods of user-involvement and approaches to accessibility. The paper makes recommendations for a change of approach to user-participation in large-scale, long-duration projects. The paper adds new insight on an under...

  14. Community Involvement in TB Research

    NARCIS (Netherlands)

    M. van der Werf (Marloes); S.G. Heumann (Silke); E.M.H. Mitchell

    2011-01-01

    textabstractWhile communities at risk have been both drivers and partners in HIV research, their important role in TB research is yet to be fully realized. Involvement of communities in tuberculosis care and prevention is currently on the international agenda. This creates opportunities and

  15. Putaminal involvement in Rasmussen encephalitis

    International Nuclear Information System (INIS)

    Rajesh, Bhagavatheeswaran; Ashalatha, Radhakrishnan; Kesavadas, Chandrasekharan; Thomas, Bejoy

    2006-01-01

    Rasmussen encephalitis (RE) is a rare devastating disease of childhood causing progressive neurological deficits and intractable seizures, typically affecting one hemisphere. Characteristic MRI features include progressive unihemispheric focal cortical atrophy and grey- or white-matter high-signal changes and basal ganglion involvement, particularly of the caudate nucleus. To analyse the pattern of involvement of different brain structures in a series of patients with RE and to attempt clinical correlation. We reviewed the medical records and neuroimaging data of 12 patients diagnosed with RE satisfying the European Consensus Statement diagnostic criteria. The disease manifested as seizures in all patients and was refractory; epilepsia partialis continua was a notable feature (nine patients). Hemiparesis of varying grades was noted in all but one patient; none had extrapyramidal signs. Neuroimaging showed cortical involvement in the insular/periinsular regions in 11 patients. Caudate atrophy was noted in ten patients. Putaminal atrophy was seen in nine patients, six of whom had additional hyperintense signal changes. Our study highlights frequent putaminal atrophy and signal changes in RE, which suggests a more extensive basal ganglion involvement than emphasized previously. Recognition of putaminal changes may be a useful additional tool in the radiological diagnosis of RE. (orig.)

  16. Corporate Involvement in C AI

    Science.gov (United States)

    Baker, Justine C.

    1978-01-01

    Historic perspective of computer manufacturers and their contribution to CAI. Corporate CAI products and services are mentioned, as is a forecast for educational involvement by computer corporations. A chart of major computer corporations shows gross sales, net earnings, products and services offered, and other corporate information. (RAO)

  17. Parental Involvement in Norwegian Schools

    Science.gov (United States)

    Paulsen, Jan Merok

    2012-01-01

    This article examines findings on key challenges of school-parent relations in Norway. The review is based on recent large-scale studies on several issues, including formalized school-parent cooperation, parental involvement in the pedagogical discourse, and teacher perspectives on the parents' role in the school community. Findings suggest a…

  18. Parental involvement and educational achievement

    NARCIS (Netherlands)

    Driessen, G.; Smit, F.; Sleegers, P.

    2005-01-01

    Parental involvement is seen as an important strategy for the advancement of the quality of education. The ultimate objective of this is to expand the social and cognitive capacities of pupils. In addition, special attention is paid to the children of low-educated and ethnic minority parents.

  19. Eye involvement in haematological malignancies

    NARCIS (Netherlands)

    Riemens, J.A.

    2014-01-01

    This thesis describes the involvement of the eye in haematological malignancies and focuses on two topics; primary vitreoretinal lymphoma (PVRL) and ocular Graft-versus-Host Disease (GvHD). The aim of this thesis is first: to compare the efficacy of diverse treatment options of PVRL with regard to

  20. Lupus panniculitis involving the breast

    International Nuclear Information System (INIS)

    Sabate, Josep M.; Gomez, Antonio; Torrubia, Sofia; Salinas, Teresa; Clotet, Montse; Lerma, Enrique

    2006-01-01

    Lupus panniculitis is an unusual immunological disease that characteristically affects the subcutaneous fat and occurs in 2% of patients with systemic lupus erythematosus. We report a case of lupus panniculitis involving the breast, which represents a very uncommon location. Mammographically, it presented as a suspicious irregular mass involving the subcutaneous fat pad with skin thickening. High echogenicity constituted the most relevant sonographic finding. To the best of our knowledge, the magnetic resonance (MR) features have not been previously described. High signal intensity was found on both T1- and T2-weighted precontrast MR images. A dynamic contrast-enhanced study revealed a suspicious focal mass with irregular margins and rim enhancement, with a type 3 time-signal intensity curve. Differential diagnosis with carcinoma and fat necrosis and the value of core biopsy are discussed. (orig.)

  1. Multiobjective Optimization Involving Quadratic Functions

    Directory of Open Access Journals (Sweden)

    Oscar Brito Augusto

    2014-01-01

    Full Text Available Multiobjective optimization is nowadays a word of order in engineering projects. Although the idea involved is simple, the implementation of any procedure to solve a general problem is not an easy task. Evolutionary algorithms are widespread as a satisfactory technique to find a candidate set for the solution. Usually they supply a discrete picture of the Pareto front even if this front is continuous. In this paper we propose three methods for solving unconstrained multiobjective optimization problems involving quadratic functions. In the first, for biobjective optimization defined in the bidimensional space, a continuous Pareto set is found analytically. In the second, applicable to multiobjective optimization, a condition test is proposed to check if a point in the decision space is Pareto optimum or not and, in the third, with functions defined in n-dimensional space, a direct noniterative algorithm is proposed to find the Pareto set. Simple problems highlight the suitability of the proposed methods.

  2. DHA involvement in neurotransmission process

    OpenAIRE

    Vancassel Sylvie; Aïd Sabah; Denis Isabelle; Guesnet Philippe; Lavialle Monique

    2007-01-01

    The very high enrichment of the nervous system in the polyunsaturated fatty acids, arachidonic (AA, 20: 4n-6) and docosahexaenoic acids (DHA, 22: 6n-3), is dependant of the dietary availability of their respective precursors, linoleic (18: 2n-6) and_-linolenic acids (18: 3n-3). Inadequate amounts of DHA in brain membranes have been linked to a wide variety of abnormalities ranging from visual acuity and learning irregularities, to psychopathologies. However, the molecular mechanisms involved ...

  3. Stakeholder involvement - a japanese perspective

    International Nuclear Information System (INIS)

    Kobayashi, S.

    2004-01-01

    Traditional societal and cultural background of Japanese in general indicates the intrinsic difficulty in involving the public as stakeholders in the process of any type of decision making in policy matters. It is characterized by the long-taught virtue of harmonization and obedience to others. In addition, characteristic system of Japanese traditional industrial society, such as lifetime employment, seniority-based wage system, and enterprise-based labour union, encourages the loyalty to the employer/company, but not to the public. The public or ordinary citizens would seldom come out as stakeholders and express their true feelings or real opinions, even though younger generation is notably getting out from such a trend. On the other hand, it is a common practice in Japanese society for any business or administrative transactions to try to obtain 'consensus' among relevant parties concerned (stakeholders) by negotiations behind the curtain prior to the formal discussion. In this sense, 'stakeholders involvement' is accepted and practised as a matter of course, but mostly for actions between parties of equivalently influential status levels or between 'directly relevant' parties such as those between the different government agencies, between regulators and industries. The concept of 'Involving the public in decision making as stakeholders' is not yet fully understood nor accepted in Japan both by regulators and by the public so far as the issue of radiation protection is concerned. These situations are explained with some examples. (author)

  4. Ethics in research involving prisoners.

    Science.gov (United States)

    Pont, Jörg

    2008-01-01

    Research involving prisoners repeatedly went astray during the last century, culminating in the cruel medical experiments inside the Nazi concentration camps that gave rise to the Nuremberg Code. However, prisoners continued to become victims of scientific exploitation by the rapidly evolving biomedical research industry. The common roots of these abuses were the flawed philosophy that the needs of the society outweigh the needs of the individual and the researchers' view that prisoners are cheap, easy to motivate and stable research subjects. Prisoners are vulnerable to exploitation and abuse by research because their freedom for consent can easily be undermined, and because of learning disabilities, illiteracy and language barriers prevailing within prisoner populations. Therefore, penal laws of some countries supported by a number of internationally agreed documents prohibit research involving prisoners completely. However, prisoners must also be regarded as vulnerable to the specific health problems in prisons, e.g. transmissible diseases, mental disorders and suicide - problems that need to be addressed by research involving prisoners. Additionally, the participation of prisoner patients in research they directly can benefit from should be provided. Hence, it must be a common objective to find the right balance between protection from exploitation and access to research beneficial to prisoners.

  5. Stakeholder involvement in developing brochures

    International Nuclear Information System (INIS)

    Vargas, M.; Garing, K.; Waldrop, D.

    1994-01-01

    The Department of Energy's (DOE's) Office of Environmental Management involved stakeholders (i.e., people who perceive themselves to be affected by the DOE's activities) in a pre-decisional draft of a DOE public document-a practice that the public has called for if the DOE is to begin real public participation. Early and ongoing public input is key to realizing Environmental Management's goal of increasing public participation. The stakeholder review process employed in the development of this document, a brochure outlining public participation information, demonstrates that Environmental Management is open-quotes practicing what it preachesclose quotes about institutionalizing public participation in its program. environmental Management's objective for the brochure is to create a document that uses plain, direct language that encourages citizens to become involved in its decision making process. The information in the brochure provides the public with the information they need to become involved stakeholders. The breadth and volume of comments received assisted in the development of a brochure that includes many viewpoints

  6. Tingkat Kesetaraan Gender Ingkat Kesetaraan Gender Pada Industri Kulit Di Propinsi Daerah Istimewa Yogayakarta

    OpenAIRE

    Priyadi, Unggul; Astuti, Budi

    2009-01-01

    Leather industry is one of small industries in Special Yogyakarta Province which contributes Regional Gross Domestic Product (PDRB) and generates employment. This re¬search analyzes cross section data in 2000th using purposive sampling method for data col¬lecting. Data analysis is Gender Inequality and Equivalent Index (IKKG) and Logit Model. Based on the empirical analysis, conclusions of this research are: 1) IKKG of entrepreneur leathers who have Educational Elementary School (SD), SMP, an...

  7. DHA involvement in neurotransmission process

    Directory of Open Access Journals (Sweden)

    Vancassel Sylvie

    2007-05-01

    Full Text Available The very high enrichment of the nervous system in the polyunsaturated fatty acids, arachidonic (AA, 20: 4n-6 and docosahexaenoic acids (DHA, 22: 6n-3, is dependant of the dietary availability of their respective precursors, linoleic (18: 2n-6 and_-linolenic acids (18: 3n-3. Inadequate amounts of DHA in brain membranes have been linked to a wide variety of abnormalities ranging from visual acuity and learning irregularities, to psychopathologies. However, the molecular mechanisms involved remain unknown. Several years ago, we hypothesized that a modification of DHA contents of neuronal membranes by dietary modulation could change the neurotransmission function and then underlie inappropriate behavioural response. We showed that, in parallel to a severe loss of brain DHA concomitant to a compensatory substitution by 22:5n-6, the dietary lack of α-linolenic acid during development induced important changes in the release of neurotransmitters (dopamine, serotonin, acetylcholine in cerebral areas specifically involved in learning, memory and reward processes. Data suggested alteration of presynaptic storage process and dysregulations of reciprocal functional interactions between monoaminergic and cholinergic pathways. Moreover, we showed that recovery of these neurochemical changes was possible when the deficient diet was switched to a diet balanced in n-3 and n-6 PUFA before weaning. The next step is to understand the mechanism involved. Particularly, we focus on the study of the metabolic cooperation between the endothelial cell, the astrocyte and the neuron which regulate synaptic transmission.These works could contribute to the understanding of the link between some neuropsychiatric disorders and the metabolism of n-3 PUFA, through their action on neurotransmission.

  8. Relapsing polychondritis and airway involvement.

    Science.gov (United States)

    Ernst, Armin; Rafeq, Samaan; Boiselle, Phillip; Sung, Arthur; Reddy, Chakravarthy; Michaud, Gaetane; Majid, Adnan; Herth, Felix J F; Trentham, David

    2009-04-01

    To assess the prevalence and characteristics of airway involvement in relapsing polychondritis (RP). Retrospective chart review and data analysis of RP patients seen in the Rheumatology Clinic and the Complex Airway Center at Beth Israel Deaconess Medical Center from January 2004 through February 2008. RP was diagnosed in 145 patients. Thirty-one patients had airway involvement, a prevalence of 21%. Twenty-two patients were women (70%), and they were between 11 and 61 years of age (median age, 42 years) at the time of first symptoms. Airway symptoms were the first manifestation of disease in 17 patients (54%). Dyspnea was the most common symptom in 20 patients (64%), followed by cough, stridor, and hoarseness. Airway problems included the following: subglottic stenosis (n = 8; 26%); focal and diffuse malacia (n = 15; 48%); and focal stenosis in different areas of the bronchial tree in the rest of the patients. Twelve patients (40%) required and underwent intervention including balloon dilatation, stent placement, tracheotomy, or a combination of the above with good success. The majority of patients experienced improvement in airway symptoms after intervention. One patient died during the follow-up period from the progression of airway disease. The rest of the patients continue to undergo periodic evaluation and intervention. In this largest cohort described in the English language literature, we found symptomatic airway involvement in RP to be common and at times severe. The nature of airway problems is diverse, with tracheomalacia being the most common. Airway intervention is frequently required and in experienced hands results in symptom improvement.

  9. Behcet's disease involving the breast

    International Nuclear Information System (INIS)

    Soleto, Maria Jesus; Marcos, Lourdes

    2002-01-01

    Behcet's disease is a vasculitis of unknown origin that was traditionally defined by oral and genital ulcers and uveitis. We describe a case of a patient with a diagnosis of Behcet's syndrome who presented a palpable lesion in the right breast with inflammatory signs. X-ray findings posed a differential diagnosis between tumoral and inflammatory pathology. The pathological findings confirmed a small-vessel vasculitis. We found two reports of breast involvement by this disease in the literature. Our patient was studied by mammogram and sonogram which together with clinical history are important to prevent delay in diagnosis and unnecessary therapeutic procedures. (orig.)

  10. Neuronal involvement in cisplatin neuropathy

    DEFF Research Database (Denmark)

    Krarup-Hansen, A; Helweg-Larsen, Susanne Elisabeth; Schmalbruch, H

    2007-01-01

    of large dorsal root ganglion cells. Motor conduction studies, autonomic function and warm and cold temperature sensation remained unchanged at all doses of cisplatin treatment. The results of these studies are consistent with degeneration of large sensory neurons whereas there was no evidence of distal......Although it is well known that cisplatin causes a sensory neuropathy, the primary site of involvement is not established. The clinical symptoms localized in a stocking-glove distribution may be explained by a length dependent neuronopathy or by a distal axonopathy. To study whether the whole neuron...

  11. Neuronal involvement in cisplatin neuropathy

    DEFF Research Database (Denmark)

    Krarup-Hansen, A; Helweg-Larsen, Susanne Elisabeth; Schmalbruch, H

    2007-01-01

    Although it is well known that cisplatin causes a sensory neuropathy, the primary site of involvement is not established. The clinical symptoms localized in a stocking-glove distribution may be explained by a length dependent neuronopathy or by a distal axonopathy. To study whether the whole neuron...... of the foot evoked by a tactile probe showed similar changes to those observed in SNAPs evoked by electrical stimulation. At these doses, somatosensory evoked potentials (SEPs) from the tibial nerve had increased latencies of peripheral, spinal and central responses suggesting loss of central processes...

  12. Cardiopulmonary involvement in Fabry's disease.

    Science.gov (United States)

    Koskenvuo, Juha W; Kantola, Ilkka M; Nuutila, Pirjo; Knuuti, Juhani; Parkkola, Riitta; Mononen, Ilkka; Hurme, Saija; Kalliokoski, Riikka; Viikari, Jorma S; Wendelin-Saarenhovi, Maria; Kiviniemi, Tuomas O; Hartiala, Jaakko J

    2010-04-01

    Fabry's disease is an X-linked lysosomal storage disease caused by deficiency of alpha-galactosidase A enzyme activity. Decreased enzyme activity leads to accumulation of glycosphingolipid in different tissues, including endothelial and smooth-muscle cells and cardiomyocytes. There is controversial data on cardiopulmonary involvement in Fabry's disease, because many reports are based on small and selected populations with Fabry's disease. Furthermore, the aetiology of cardiopulmonary symptoms in Fabry's disease is poorly understood. We studied cardiopulmonary involvement in seventeen patients with Fabry's disease (20-65 years, 6 men) using ECG, bicycle stress, cardiac magnetic resonance imaging, spirometry, diffusing capacity and pulmonary high-resolution computed tomography (HRCT) tests. Cardiopulmonary symptoms were compared to observed parameters in cardiopulmonary tests. Left ventricular hypertrophy (LVH) and reduced exercise capacity are the most apparent cardiac changes in both genders with Fabry's disease. ECG parameters were normal when excluding changes related to LVH. Spirometry showed mild reduction in vital capacity and forced expiratory volume in one second (FEV I), and mean values in diffusing capacity tests were within normal limits. Generally, only slight morphological pulmonary changes were detected using pulmonary HRCT, and they were not associated with changes in pulmonary function. The self-reported amount of pulmonary symptoms associated only with lower ejection fraction (P routine cardiopulmonary evaluation in Fabry's disease using echocardiography is maybe enough when integrated to counselling for aerobic exercise training.

  13. Subfascial involvement in glomuvenous malformation

    Energy Technology Data Exchange (ETDEWEB)

    Shaikh, Raja; Alomari, Ahmad I.; Chaudry, Gulraiz [Boston Children' s Hospital, Division of Interventional Radiology, Boston, MA (United States); Mulliken, John B. [Boston Children' s Hospital, Division of Plastic Surgery, Boston, MA (United States); Fishman, Steven J. [Boston Children' s Hospital, Department of Surgery, Boston, MA (United States); Kozakewich, Harry P.W. [Boston Children' s Hospital, Department of Pathology, Boston, MA (United States)

    2014-07-15

    Glomuvenous malformation (GVM) is an inherited autosomal dominant trait. The lesions, which appear as bluish nodules or plaque-like cutaneous elevations, are usually tender and more firm than sporadic venous malformations. Conventionally, the lesions are thought to be limited to the cutaneous and subcutaneous tissue planes. The objective was to characterize the depth of involvement of GVM lesions. Magnetic resonance imaging (MRI) findings in GVM were retrospectively evaluated by two radiologists. The signal characteristics, tissue distribution, pattern of contrast enhancement of the lesions in GVM were documented. Thirty patients (19 female) aged 1-35 years (mean 18 years) were diagnosed with GVM based on clinical features (n = 20) and/or histopathological findings (n = 10). The lesions were present in the lower extremity (n = 15), upper extremity (n = 6), cervico-facial region (n = 6), pelvis (n = 2), and chest wall (n = 1). All patients had skin and subcutaneous lesions. Fifty percent of the patients (n = 15) demonstrated subfascial intramuscular (n = 15), intra-osseous (n = 1), and intra-articular involvement (n = 1). Contrary to the conventional belief that GVMs are generally limited to the skin and subcutaneous tissue, deep subfascial extension of the lesions is common. (orig.)

  14. Modeling interdisciplinary activities involving Mathematics

    DEFF Research Database (Denmark)

    Iversen, Steffen Møllegaard

    2006-01-01

    In this paper a didactical model is presented. The goal of the model is to work as a didactical tool, or conceptual frame, for developing, carrying through and evaluating interdisciplinary activities involving the subject of mathematics and philosophy in the high schools. Through the terms...... of Horizontal Intertwining, Vertical Structuring and Horizontal Propagation the model consists of three phases, each considering different aspects of the nature of interdisciplinary activities. The theoretical modelling is inspired by work which focuses on the students abilities to concept formation in expanded...... domains (Michelsen, 2001, 2005a, 2005b). Furthermore the theoretical description rest on a series of qualitative interviews with teachers from the Danish high school (grades 9-11) conducted recently. The special case of concrete interdisciplinary activities between mathematics and philosophy is also...

  15. Measuring Purchase‐decision involvement ,

    Directory of Open Access Journals (Sweden)

    Naser Azad

    2014-08-01

    Full Text Available Nowadays, increasing competition is forcing businesses to pay more attention on customer satisfaction providing strong customer services. Increased competition has also increased marketing activities. This paper presents an empirical investigation to determine important factors influencing purchase decision involvement in food industry in city of Tehran, Iran. The study designs a questionnaire in Likert scale, distributes it among 270 experts in food industry and, using principle component (PCA analysis, extracts important group of factors. The questionnaire consists of 27 questions, which is reduced to 23 questions because of sensitivity of the PCA to Skewness of data. Cronbach alpha is calculated as 0.81, which is well above the minimum acceptable level. The results indicate that there were four factors including individual differences, product validation, triggers and dependent behavior influencing purchasing decisions.

  16. Pulmonary involvement of secondary syphilis.

    Science.gov (United States)

    Ogawa, Yoshihiko; Imai, Yuichiro; Yoshihara, Shingo; Fujikura, Hiroyuki; Hirai, Nobuyasu; Sato, Masatoshi; Ogawa, Taku; Uno, Kenji; Kasahara, Kei; Yano, Hisakazu; Mikasa, Keiichi

    2018-01-01

    Pulmonary involvement in secondary syphilis is considered a rare occurrence; however, the number of cases has increased in the 2000s. This is likely due to the increased use of computed tomography scans and molecular diagnostic testing. We report a case of an HIV-positive man with pleural chest pain and bilateral subpleural nodules on chest computed tomography. His rapid plasma reagin and Treponema pallidum hemagglutination tests were positive, and the specimen of one of the pulmonary nodules obtained by transthoracic biopsy was positive for the polA gene of Treponema pallidum. Since clinical manifestations of syphilis are highly variable, clinicians should bear in mind that pleural chest pain with bilateral subpleural nodules can be caused by pulmonary syphilis.

  17. Kidney involvement in rheumatoid arthritis

    Directory of Open Access Journals (Sweden)

    P. Lazzarini

    2011-09-01

    Full Text Available Rheumatoid Arthritis (RA is a widespread disease and its renal involvement, relatively common, is clinically significant because worsens course and mortality of the primary disease. There is still no agreement on the prevalence of renal disorders in RA: data analysis originates from different sources, as death certificates, autopsies, clinical and laboratory findings and kidney biopsies, each with its limitations. Histoimmunological studies on bioptical specimens of patients with RA and kidney damage, led to clarify prevalent pathologies. In order of frequency: glomerulonephritis and amyloidosis (60-65% and 20-30% respectively, followed by acute or chronic interstitial nephritis. Kidney injury during RA includes secondary renal amyloidosis, nephrotoxic effects of antirheumatic drugs and nephropathies as extra-articular manifestations (rheumatoid nephropathy. Amyloidosis affects survival, increases morbidity and is the main cause of end stage renal disease in patients with RA and nephropathy. Strong association between RA activity and amyloidosis needs the use of immunosuppressive and combined therapies, to prevent this complication and reduce risk of dialysis. Long-lasting and combined RA pharmacotherapy involves various renal side effects. In this review we describe NSAIDs and DMARDs (Disease-Modifying Antirheumatic Drugs nephrotoxicity, particularly by gold compounds, D-penicillamine, cyclosporine A and methotrexate. Rare cases of IgA glomerulonephritis during immunomodulating therapy with leflunomide and TNF blocking receptor (etanercept are reported; real clinical significance of this drug-related nephropathy will be established by development of RA treatment. In RA nephropathies, mesangial glomerulonephritis is the most frequent histological lesion (35-60 % out of biopsies from patients with urinary abnormalities and/or kidney impairment, followed by minimal change glomerulopathy (3-14% and p-ANCA positive necrotizing crescentic

  18. Involve women at many levels.

    Science.gov (United States)

    Huq, N

    1995-03-01

    The organizers of the 1994 International Conference on Population and Development (ICPD) realize that slowing the rate of population growth requires the involvement of women at many levels. The planning processes in countries leading up to the ICPD were required to include women, and funds became available for women to attend regional and international preparatory meetings. National delegations at the ICPD also included many more women than the previous two world population conferences in 1974 and 1984. Space was also provided at the ICPD for the involvement of nongovernmental organizations. Naripokkho, a women's advocacy organization in Bangladesh, was therefore able to communicate its message at the conference. In preparation, the organization held consultations and workshops with grassroots women in thirteen regions of Bangladesh. Approximately one third of the women in the workshops had more children than they desired, many felt that they had to have at least two sons, poor services led women to discontinue contraceptive use, and very few women reported that a lack of access to contraception or method failure was responsible for their large families. It was also determined during the preparatory phase that environmental damage cannot be linked to population in a simplistic manner, history, politics, geography, business, and economics play important roles. Once at the ICPD, Naripokkho they negotiated and lobbied the governments to influence the ICPD program of action. Gains for women were made in both language and substance. Indeed, the program of action is the most progressive population document ever issued by a mainstream institution, gives women's goals new legitimacy, and is a powerful tool for groups working at the grassroots level. Governments must now be held to their commitments made in the program.

  19. Nail involvement in psoriatic arthritis

    Directory of Open Access Journals (Sweden)

    Piotr Sobolewski

    2017-07-01

    Full Text Available Nail psoriasis is considered a significant psychological and social problem causing functional impairment in affected patients. Nail changes hamper their daily and occupational activities and contribute to a worse quality of life. Almost 50% of patients with psoriasis vulgaris and up to 80% of patients with psoriatic arthritis are afflicted with nail lesions. The important correlation between psoriatic arthritis and nail changes is well established – the presence of the latter is a strong predictor of the development of arthritis. There is a broad spectrum of nail dystrophies associated with psoriasis, ranging from the common pitting, subungual hyperkeratosis and loosening of the nail plate to less frequent discolouration and splinter haemorrhages. Some of these symptoms are also observed in other nail diseases, and further diagnostics should be performed. The assessment tools NAPSI (Nail Psoriasis Severity Index, mNAPSI (Modified Nail Psoriasis Severity Index, and PNSS (Psoriasis Nail Severity Score are most commonly used to grade the severity of nail involvement in psoriasis and enable the evaluation of therapy effectiveness. The treatment of nail psoriasis is a major clinical challenge. It should be adjusted to the extent of dermal, articular and ungual lesions. Systemic therapies of psoriasis, especially biological agents, are most likely to be effective in treating nail psoriasis. However, as their use is limited in scope and safety, topical therapy remains a mainstay, and the combination of corticosteroids and vitamin D3 analogues is considered to be most helpful.

  20. Public involvement in nuclear decisions

    International Nuclear Information System (INIS)

    Ferte, J. De La

    1993-01-01

    Over the last two decades, the environment has gained an understandable degree of political prominence, drawing attention to the concept of direct participation of the public in decision-making. As part of that process, the first World Environmental Conference in Stockholm in 1972, the final act of the 1975 Helsinki Conference, the Global Nature Charter of the UN General Assembly of 1982 and the 1992 Rio conference have all increased the obligation of governments to inform their publics, and to give individuals and all categories of the public some degree of involvement in decisions that will directly affect their surroundings. The use of nuclear energy fits clearly into this process. Uncertainty in the public mind about the scientific foundation of nuclear-energy exploitation often motivates the public to intervene in the decision-making process, as does fear of catastrophic consequences. There can also be a specific reaction -crystallizing on nuclear energy - against uncontrolled technological and unlimited industrial development. In any event, there is a direct relationship between public pressure for participation and the perception of the ability - or inability - of the relevant authorities to act with a genuine sense of the wider interest. But, although the nuclear industry has often been taken as a scapegoat, the problems of public acceptance and government management that it raises are not substantially different from those in other branches of heavy industry, particularly in their social and environmental impacts. Indeed, in a large number of countries (France, Germany, the United Kingdom and the United States are examples) the mechanisms for public participation are broadly similar for both conventional industrial and nuclear installations

  1. Parent Involvement in Homework: A Research Synthesis

    Science.gov (United States)

    Patall, Erika A.; Cooper, Harris; Robinson, Jorgianne Civey

    2008-01-01

    New emphasis is being placed on the importance of parent involvement in children's education. In a synthesis of research on the effects of parent involvement in homework, a meta-analysis of 14 studies that manipulated parent training for homework involvement reveals that training parents to be involved in their child's homework results in (a)…

  2. Disagreement in Parental Reports of Father Involvement

    Science.gov (United States)

    Charles, Pajarita; Spielfogel, Jill; Gorman-Smith, Deborah; Schoeny, Michael; Henry, David; Tolan, Patrick

    2016-01-01

    Despite agreement on the value of father involvement in children’s lives, research has been limited due to the exclusion of fathers in studies, questionable validity of mothers’ reports on father involvement, and simple measures of fathering behavior. Our study extends previous research by comparing reports of father involvement using robust, multidimensional father involvement measures. Data from 113 fathers and 126 mothers reporting on 221 children were used to assess father involvement. Results indicate that fathers reported significantly higher levels of involvement than mothers reported. Findings from hierarchical linear models suggest that race/ethnicity and mothers’ reports of positive relationship quality were associated with smaller discrepancies in reports of father involvement, whereas nonmarried partnerships, older children, father residence, and biological status predicted larger discrepancies. Our study demonstrates the importance of obtaining father involvement reports directly from fathers and why father involvement should be assessed as a multidimensional construct to examine fathering behavior. PMID:29515272

  3. Trucks involved in fatal accidents factbook 2008.

    Science.gov (United States)

    2011-03-01

    This document presents aggregate statistics on trucks involved in traffic accidents in 2008. The : statistics are derived from the Trucks Involved in Fatal Accidents (TIFA) file, compiled by the : University of Michigan Transportation Research Instit...

  4. Buses involved in fatal accidents factbook 2007

    Science.gov (United States)

    2010-03-01

    This document presents aggregate statistics on buses involved in traffic accidents in 2007. The : statistics are derived from the Buses Involved in Fatal Accidents (BIFA) file, compiled by the : University of Michigan Transportation Research Institut...

  5. Trucks involved in fatal accidents factbook 2007.

    Science.gov (United States)

    2010-01-01

    This document presents aggregate statistics on trucks involved in traffic accidents in 2007. The : statistics are derived from the Trucks Involved in Fatal Accidents (TIFA) file, compiled by the : University of Michigan Transportation Research Instit...

  6. Quality assurance - how to involve the employees

    DEFF Research Database (Denmark)

    Jørgensen, Michael Søgaard

    1996-01-01

    An overview of strategies for involvement of employees in quality assurance developement and implementation.......An overview of strategies for involvement of employees in quality assurance developement and implementation....

  7. Involving Nepali academics in health research

    DEFF Research Database (Denmark)

    Neupane, Dinesh; van Teijlingen, E; Khanal, V

    2013-01-01

    Many academics from Nepal do not involve in research activities. There are several factors hindering the involvement such as inadequate human resources and lack of financial resources. Despite limited human and financial resources, we believe it is still possible to attract many Nepali academics...... in health research. This paper purposes some ideas to increase involvement of Nepali academics in health research....

  8. Cross-Cultural Issues in Parent Involvement.

    Science.gov (United States)

    Tran, Bach-Tuyet Pham; And Others

    Four papers address cultural issues related to the involvement of limited-English-proficient parents in public schools in the United States. "Cultural Issues in Indochinese Parent Involvement" (Bach-Tuyet (Pham) Tran) outlines the linguistic, social, and practical barriers to Indochinese immigrant parent involvement and makes suggestions for…

  9. Radiologic science students' perceptions of parental involvement.

    Science.gov (United States)

    DuBose, Cheryl; Barymon, Deanna; Vanderford, Virginia; Hensley, Chad; Shaver, Gary

    2014-01-01

    A new generation of students is in the classroom, and they are not always alone. Helicopter parents, those who hover around the student and attempt to ease life's challenges, are accompanying the students to radiologic science programs across the nation. To determine radiologic science students' perception regarding their parents' level of involvement in their lives. A survey focused on student perceptions of parental involvement inside and outside of the academic setting was completed by 121 radiologic science students at 4 institutional settings. The analysis demonstrates statistically significant relationships between student sex, age, marital status, and perceived level of parental involvement. In addition, as financial support increases, students' perception of the level of parental involvement also increases. Radiologic science students want their parents to be involved in their higher education decisions. Research indicates that students with involved parents are more successful, and faculty should be prepared for increased parental involvement in the future. Radiologic science students perceive their parents to be involved in their academic careers. Ninety-five percent of respondents believe that the financial support of their parent or parents contributes to their academic success. Sixty-five percent of participants are content with their parents' current level of involvement, while 11% wish their parents were more involved in their academic careers.

  10. Top Management Involvement in New Product Development

    DEFF Research Database (Denmark)

    Felekoglu, Burcu; Maier, Anja; Moultrie, James

    2010-01-01

    a broader conceptual space than this participation. This paper reviews the literature on top management involvement in new product development (NPD) and discusses relevance of different theoretical perspectives from other disciplines such as management, organisational behaviour and communication to analyse......Involvement of top managers in new product development (NPD) is a critical factor affecting NPD performance and frequently considered to be the participation of top management to certain activities in NPD or their NPD related behaviours. However, “Top management involvement in NPD” occupies...... antecedents, realisation and consequences of top management involvement in NPD. It is argued that top management has different involvement at different NPD levels: organisation level and project level. Resulting from this literature review, a tentative framework for top management involvement in NPD...

  11. How can stakeholder involvement be improved?

    International Nuclear Information System (INIS)

    2015-12-01

    Radioactive waste management is embedded in broader societal issues such as environment, risk management, sustainability, energy and health policy. In all these fields, there is an increasing demand for public involvement, participation or engagement. Guidance for public authorities also generally encourages greater involvement of the public. Involvement may take different forms at different phases and can include sharing information, consulting, dialoguing or deliberating on decisions with relevant stakeholders. Stakeholder involvement should be seen as a meaningful part of formulating and implementing public policy. There is no single technique for organising engagement. Initiatives should respond to their context and to stakeholders' particular needs. As the number of stakeholder involvement approaches and publications describing them continues to grow, new opportunities are opening up through social media, which has become an important tool for stakeholder involvement in recent years

  12. Does employee involvement work? Yes, sometimes.

    Science.gov (United States)

    Cotton, J L

    1997-12-01

    Employee involvement per se is not always effective for improving performance and/or employee attitudes. Rather, there are several different forms of employee involvement, some of which are effective, while others are not. This article describes seven forms of employee involvement, giving examples, and summarizes research findings for each form, concluding with a summary of which are the best and which are worst. This article also describes what is necessary for effective employee involvement, focusing on management commitment and training for both management and employees.

  13. Client Involvement in Home Care Practice

    DEFF Research Database (Denmark)

    Glasdam, Stinne; Henriksen, Nina; Kjær, Lone

    2013-01-01

    , political and administrative frames that rule home- care practice. Client involvement is shown within four constructed analytical categories: ‘Structural conditions of providing and receiving home care’; ‘Client involvement inside the home: performing a professional task and living an everyday life......’; ‘Client involvement outside the home: liberal business and mutual goal setting’; and ‘Converting a home to a working place: refurnishing a life’. The meaning of involvement is depending on which position it is viewed from. On the basis of this analysis, we raise the question of the extent to which...

  14. Liver involvement in Langerhans cell histiocytosis

    International Nuclear Information System (INIS)

    Wong, Adelaine; Ortiz-Neira, Clara L.; Abou Reslan, Walid; Kaura, Deepak; Sharon, Raphael; Anderson, Ronald; Pinto-Rojas, Alfredo

    2006-01-01

    Liver involvement in Langerhans cell histiocytosis (LCH) typically presents with hepatomegaly and other signs of liver dysfunction. We present an 11-month-old child having only minimally elevated liver enzymes as an indication of liver involvement. Using sonography as the initial diagnostic tool followed by MRI, LCH of the liver was revealed. A review of sonographic, CT, MRI and MR cholangiopancreatography findings in liver LCH is presented. We recommend that physicians consider sonography and MRI screening for liver involvement in patients with newly diagnosed LCH, as periportal involvement may be present with little or no liver function abnormality present, as in this patient. (orig.)

  15. Initial thoracic involvement in lymphoma. CT assessment

    International Nuclear Information System (INIS)

    Bustos, A.; Corredoira, J.; Ferreiros, J.; Cabeza, B.; Jorquera, M.; Pedrosa, I.; Martinez, R.; Fernandez, C.

    2002-01-01

    To analyze the initial thoracic involvement by CT in a consecutive series of patients with lymphoma. A retrospective analysis was made of thoracic CT studies made at the time of diagnosis of 259 patients with lymphoma. Mediastinal pulmonary, pleural, pericardial and chest wall involvement was assessed by CT. Of 259 patients (129 men y 130 women), 56 had Hodgkin's disease (HD) and 203 had non-Hodgkin lymphoma (NHL). Forty-two percent (42.5%, 110/259) of the patients had chest involvement on CT: 33 of 56 patients with HD (58.9%) and 77 of 203 patients with NHL (37.9%). All the patients with thoracic HD) and 71.4% of patients with thoracic NHL, had mediastinal lymph node involvement. of the patients with thoracic involvement 12.1% (4/33) of the patient with HD and 23.3% (18/77) of the patients with NHL had pulmonary involvement. Thoracic involvement on CT was more frequent in HD. Mediastinal lymph node involvement was the most common finding fundamentally in HD. Pulmonary disease always occurred in the presence of mediastinal lymph node involvement in HD but could occur as an isolated finding in NHL. (Author) 24 refs

  16. Parent Involvement: Turning Up the Heat

    Science.gov (United States)

    Wherry, John H.

    2004-01-01

    Research shows that parent involvement makes a significant difference in children's achievement, especially during elementary and middle school. Even though the school year is well underway, there is still plenty of time to make this your school's best year ever for parent involvement. Here are some of the most effective strategies I've come…

  17. Understanding the Value of Volunteer Involvement

    Science.gov (United States)

    Terry, Bryan; Harder, Amy; Pracht, Dale

    2011-01-01

    Volunteers can be an important resource of many nonprofit organizations. The ability to meet the mission, goals and objectives of nonprofit organizations often depends upon the effectiveness of volunteer involvement in direct service delivery or indirect program support. Volunteer involvement utilizes financial and non-financial resources of an…

  18. Pioneering partnerships: Resident involvement from multiple perspectives

    NARCIS (Netherlands)

    Baur, V.E.; Abma, T.A.; Boelsma, F.; Woelders, S.

    2013-01-01

    Resident involvement in residential care homes is a challenge due to shortcomings of consumerist and formal approaches such as resident councils. The PARTNER approach aims to involve residents through collective action to improve their community life and wellbeing. The purpose of this article is to

  19. Bullying Prevention and the Parent Involvement Model

    Science.gov (United States)

    Kolbert, Jered B.; Schultz, Danielle; Crothers, Laura M.

    2014-01-01

    A recent meta-analysis of bullying prevention programs provides support for social-ecological theory, in which parent involvement addressing child bullying behaviors is seen as important in preventing school-based bullying. The purpose of this manuscript is to suggest how Epstein and colleagues' parent involvement model can be used as a…

  20. Parent Education: A Perspective on Involvement.

    Science.gov (United States)

    Biro, Jean

    1979-01-01

    The article reviews ways in which parents of handicapped children can become involved with the schools, and two models (an oral program for deaf students in which parents are trained to provide language stimulation, and a program for autistic children involving parents in behavioral treatment) are described. (CL)

  1. Fathers' and Mothers' Involvement with Their Adolescents

    Science.gov (United States)

    Phares, Vicky; Fields, Sherecce; Kamboukos, Dimitra

    2009-01-01

    We explored mothers' and fathers' time spent with their adolescents and found that mothers reported spending more time with their adolescents than did fathers. Developmental patterns were found for some aspects of time involvement, with both mothers and fathers reporting higher involvement with younger adolescents. Ratings of time-spent were not…

  2. Methodological issues involved in conducting qualitative research ...

    African Journals Online (AJOL)

    The purpose of this article is to describe the methodological issues involved in conducting qualitative research to explore and describe nurses' experience of being directly involved with termination of pregnancies and developing guidelines for support for these nurses. The article points out the sensitivity and responsibility ...

  3. Buses involved in fatal accidents codebook 2008.

    Science.gov (United States)

    2011-03-01

    This report provides documentation for UMTRIs file of Buses Involved in Fatal Accidents (BIFA), 2008, : including distributions of the code values for each variable in the file. The 2008 BIFA file is a census of all : buses involved in a fatal acc...

  4. Buses involved in fatal accidents codebook 2007.

    Science.gov (United States)

    2009-12-01

    This report provides documentation for UMTRIs file of Buses Involved in Fatal Accidents (BIFA), 2007, : including distributions of the code values for each variable in the file. The 2007 BIFA file is a census of all : buses involved in a fatal acc...

  5. Community Involvement in Marine Protected Areas.

    Science.gov (United States)

    Kaza, Stephanie

    1988-01-01

    Lists several key concepts in developing successful interpretive programs for marine protected areas with community involvement. Identifies educational tools that help foster community involvement in conservation and management. Cites three model programs. Sets standards and goals for international success including leadership, education,…

  6. Patient involvement in Danish health care

    DEFF Research Database (Denmark)

    Vrangbaek, Karsten

    2015-01-01

    PURPOSE: The purpose of this paper is to investigate different types of patient involvement in Denmark, and to discuss the potential implications of pursuing several strategies for patient involvement simultaneously. DESIGN/METHODOLOGY/APPROACH: The paper presents a preliminary framework for anal......PURPOSE: The purpose of this paper is to investigate different types of patient involvement in Denmark, and to discuss the potential implications of pursuing several strategies for patient involvement simultaneously. DESIGN/METHODOLOGY/APPROACH: The paper presents a preliminary framework...... for analysis of patient involvement in health care. This framework is used to analyze key governance features of patient involvement in Denmark based on previous research papers and reports describing patient involvement in Danish health care. FINDINGS: Patient involvement is important in Denmark...... be identified when pursuing the strategies at the same time. RESEARCH LIMITATIONS/IMPLICATIONS: Because of the chosen research approach, the research results may lack generalizability. Therefore, researchers are encouraged to test the proposed framework further. PRACTICAL IMPLICATIONS: The paper includes...

  7. Addressing Measurement Issues Related to Bullying Involvement

    Science.gov (United States)

    Casper, Deborah M.; Meter, Diana J.; Card, Noel A.

    2015-01-01

    In this article, we address measurement issues related to select aspects of bullying involvement with the goal of moving psychometrically sound measurement practices toward applied bullying research. We first provide a nontechnical introduction to psychometric considerations in measuring bullying involvement, highlighting the importance of…

  8. Getting Involved in the IEP Process

    Science.gov (United States)

    Kowalski, Ellen; Lieberman, Lauren J.; Daggett, Sara

    2006-01-01

    Although, in many districts, physical educators are integral members of the Individualized Education Program (designed for students with disabilities such as Down syndrome and autism), in other districts, physical educators are only partially involved in the process or are not given the opportunity to be involved at all. However, the physical…

  9. Peer Involvement in Adolescent Dating Violence

    Science.gov (United States)

    Stephenson, Pam S.; Martsolf, Donna; Draucker, Claire Burke

    2013-01-01

    This study investigated the ways in which peers are involved in adolescent dating violence. Eighty-eight young adults aged 18-21 were interviewed and asked to reflect on aggressive dating relationships they experienced as teens. The researchers used grounded theory to analyze the data. Findings showed that male and female peers were involved in…

  10. Defining stakeholder involvement in participatory design processes

    NARCIS (Netherlands)

    Vink, P.; Imada, A.S.; Zink, K.J.

    2008-01-01

    A participatory approach could be used to implement work place or organizational improvements. However, the question is which participants should be involved and how. In this paper the theoretical involvement in different steps of a linear stepwise approach is described and compared with the latest

  11. Road accidents involving bicycles: configurations and injuries.

    Science.gov (United States)

    Orsi, Chiara; Montomoli, Cristina; Otte, Dietmar; Morandi, Anna

    2017-12-01

    This study analyzed the most common types of accident involving bicycles and compared the frequency of injuries. The data source was the database of German In-Depth Accident Study (GIDAS). Cases consist of bicycles and their riders involved in accidents between 2000 and 2010. In most collisions, the bicycle impacted with a car. The percentage of injured bicyclists was higher in collisions with a heavy vehicle and decreased when the bicycle impacted with lighter vehicles. A high percentage of injured bicyclists in single accidents was observed; the most severe injury was more frequently to head and extremities. Accidents involving a car and a bicycle with the right of way in a bicycle path represented about 20% of involved and injured bicyclists. The ten most frequent configurations represented about 60% of involved and injured bicyclists. These results contribute to understand the dangerous scenarios for bicyclists and to suggest preventive actions.

  12. Supporting Active User Involvment in Prototyping

    DEFF Research Database (Denmark)

    Grønbæk, Kaj

    1990-01-01

    The term prototyping has in recent years become a buzzword in both research and practice of system design due to a number of claimed advantages of prototyping techniques over traditional specification techniques. In particular it is often stated that prototyping facilitates the users' involvement...... in the development process. But prototyping does not automatically imply active user involvement! Thus a cooperative prototyping approach aiming at involving users actively and creatively in system design is proposed in this paper. The key point of the approach is to involve users in activities that closely couple...... development of prototypes to early evaluation of prototypes in envisioned use situations. Having users involved in such activities creates new requirements for tool support. Tools that support direct manipulation of prototypes and simulation of behaviour have shown promise for cooperative prototyping...

  13. User involvement in the innovation process

    DEFF Research Database (Denmark)

    Christensen, Dan Saugstrup

    2008-01-01

    User involvement in the innovation process is not a new phenomenon. However, combined with the growing individualisation of demand and with highly competitive and dynamic environments, user involvement in the innovation process and thereby in the design, development, and manufacturing process, can...... nevertheless provide a competitive advantage. This is the case as an intensified user involvement in the innovation process potentially results in a more comprehensive understanding of the user needs and requirements and the context within which these are required, and thereby provides the possibility...... of developing better and more suitable products. The theoretical framework of this thesis is based on user involvement in the innovation process and how user involvement in the innovation process can be deployed in relation to deriving and colleting user needs and requirements, and thereby serves...

  14. Comparing methods for involving users in ideation

    DEFF Research Database (Denmark)

    Nicolajsen, Hanne Westh; Scupola, Ada; Sørensen, Flemming

    2015-01-01

    workshop method (involving users and employees) is especially good at qualifying and further developing ideas. The findings suggest that methods for involving users in ideation should be carefully selected and combined to achieve optimum benefits and avoid potential disadvantages.......In this paper we discuss how users may be involved in the ideation phase of innovation. The study compares the use of a blog and three future workshops (students, employees and a mix of the two) in a library. Our study shows that the blog is efficient in giving the users voice whereas the mixed...

  15. Fathers' Leave, Fathers' Involvement and Child Development

    DEFF Research Database (Denmark)

    del Carmen Huerta, Maria; Lausten, Mette; Baxter, Jennifer

    involved’ perform better during the early years than their peers with less involved fathers. This paper analyses data of four OECD countries — Australia; Denmark; United Kingdom; United States — to describe how leave policies may influence father’s behaviours when children are young and whether...... their involvement translates into positive child cognitive and behavioural outcomes. This analysis shows that fathers’ leave, father’s involvement and child development are related. Fathers who take leave, especially those taking two weeks or more, are more likely to carry out childcare related activities when...

  16. User involvement in mental health rehabilitation

    DEFF Research Database (Denmark)

    Petersen, Kirsten; Hounsgaard, Lise; Borg, Tove

    2012-01-01

    reading, structural analysis, and critical interpretation. Findings: The study showed that user involvement in rehabilitation was experienced by the users as a struggle for self-determination and recognition. Being able to decide and to have influence on daily activities and everyday life, together...... with having goals to reach during rehabilitation, were viewed as valuable. Situations without influence or involving coercion were reported especially during periods of illness or hospitalization. Conclusions: The results of this study contribute to knowledge about user involvement from service users...

  17. Dual Headquarters Involvement in Multibusiness Firms

    DEFF Research Database (Denmark)

    Nell, Phillip Christopher; Kappen, Philip; Dellestrand, Henrik

    The strategy literature has shown that headquarters involve themselves into subsidiary operations to add value. Yet, little is known about the extent to which multiple headquarters do so. Therefore, we investigate antecedents of corporate and divisional headquarters’ involvement in innovation...... development projects of subsidiaries. Analyses of 85 innovation development projects reveal that dual innovation importance (innovation that is important for the division and the rest of the firm), and dual dual embeddedness (innovating subsidiary is embedded both within the division and in the rest...... of the firm) lead to greater dual headquarters involvement, especially when the innovation development network is large. The results contribute to the literature on complex parenting and theory of selective headquarters involvement....

  18. Involvement of methyltransferases enzymes during the energy

    African Journals Online (AJOL)

    Mgina

    INVOLVEMENT OF METHYLTRANSFERASES ENZYMES DURING THE. ENERGY METABOLISM OF ..... cell extract still exhibited relatively high methanogenesis with methanol (Fig ... product CH3-CoM into methane (see Fig. 1). The HS-CoM ...

  19. Lymphangioleiomyomatosis and tuberous sclerosis with pulmonary involvement

    International Nuclear Information System (INIS)

    Pedrosa, I.; Saiz, A.; Bustos, A.; Hernando, F.

    2000-01-01

    We present two cases of pulmonary lumphangioleiomyomatosis and one case of tuberous sclerosis with pulmonary involvement describing the most characteristic features according to plain chest X-ray and high-resolution computed tomography (HRCT). (Author) 14 refs

  20. Peer Effects and Academics’ Industry Involvement

    DEFF Research Database (Denmark)

    Aschhoff, Birgit; Grimpe, Christoph

    This study explores the interaction between professional imprinting and age in the context of industry-science collaboration. Specifically, we examine the impact of localized and personal peer effects on academics’ involvement with industry and how these effects are moderated by the career age...... of the scientist. We suggest that both localized and personal peer effects drive industry involvement but that the effects from such imprinting are more pronounced for younger researchers, suggesting that professional imprinting takes place in the early stages of a scientist’s academic career. Based on a sample...... of 330 German academics in the field of biotechnology and publication data from the Science Citation Index Expanded (SCIE), we find that scientists with industry-oriented co-authors are more likely to be involved with industry (personal peer effect). Moreover, we find that the scientist’s involvement...

  1. Strengthening primary healthcare through community involvement in ...

    African Journals Online (AJOL)

    Strengthening primary healthcare through community involvement in Cross River State, Nigeria: a descriptive study. Hilary Adie, Thomas Igbang, Akaninyene Otu, Ekanem Braide, Okpok Okon, Edet Ikpi, Charles Joseph, Alexander Desousa, Johannes Sommerfeld ...

  2. Healthcare decisions: a review of children's involvement.

    Science.gov (United States)

    Baston, Jenny

    2008-04-01

    Children's rights, their ability to consent to treatment and their involvement in healthcare decisions have received considerable attention in recent years. There is some evidence to suggest that when children are involved in the decision-making process, they retain a sense of control over their situation. However there are still unresolved issues related to a child's right to decide and nurses may be confused about the extent to which children can and should be involved in decision-making. A code of practice for involving children in decisions was first suggested in 2001 and there is still a need for a consistent, structured and robust method of ensuring that children are included in the decision-making process at all stages of their health care.

  3. Posttransplantation lymphoproliferative disease involving the pituitary gland.

    Science.gov (United States)

    Meriden, Zina; Bullock, Grant C; Bagg, Adam; Bonatti, Hugo; Cousar, John B; Lopes, M Beatriz; Robbins, Mark K; Cathro, Helen P

    2010-11-01

    Posttransplantation lymphoproliferative disorders (PTLD) are heterogeneous lesions with variable morphology, immunophenotype, and molecular characteristics. Multiple distinct primary lesions can occur in PTLD, rarely with both B-cell and T-cell characteristics. Lesions can involve both grafted organs and other sites; however, PTLD involving the pituitary gland has not been previously reported. We describe a patient who developed Epstein-Barr virus-negative PTLD 13 years posttransplantation involving the terminal ileum and pituitary, which was simultaneously involved by a pituitary adenoma. Immunohistochemistry of the pituitary lesion showed expression of CD79a, CD3, and CD7 with clonal rearrangements of both T-cell receptor gamma chain (TRG@) and immunoglobulin heavy chain (IGH@) genes. The terminal ileal lesion was immunophenotypically and molecularly distinct. This is the first report of pituitary PTLD and illustrates the potentially complex nature of PTLD. Copyright © 2010 Elsevier Inc. All rights reserved.

  4. Assessment of respiratory involvement in children with ...

    African Journals Online (AJOL)

    Background: Mucopolysaccharidosis (MPS) are classified into seven clinical types based on eleven known lysosomal enzyme deficiencies of glycosaminoglycan (GAG) metabolism. Respiratory involvement seen in most MPS types includes recurrent respiratory infections, upper and lower airway obstruction, tracheomalacia ...

  5. Community Involvement and Preception towards Malaria Prevention ...

    African Journals Online (AJOL)

    Community Involvement and Preception towards Malaria Prevention and Control Strategies in Rural Areas of Kersa District in Jimma Zone, Southwest Ethiopia. Wondimu Tesgera, Makonnen Aseffa, Bishaw Deboch, Wondwossen Kassahun ...

  6. Neurologic involvement in scleroderma: a systematic review.

    Science.gov (United States)

    Amaral, Tiago Nardi; Peres, Fernando Augusto; Lapa, Aline Tamires; Marques-Neto, João Francisco; Appenzeller, Simone

    2013-12-01

    To perform a systematic review of neurologic involvement in Systemic sclerosis (SSc) and Localized Scleroderma (LS), describing clinical features, neuroimaging, and treatment. We performed a literature search in PubMed using the following MeSH terms, scleroderma, systemic sclerosis, localized scleroderma, localized scleroderma "en coup de sabre", Parry-Romberg syndrome, cognitive impairment, memory, seizures, epilepsy, headache, depression, anxiety, mood disorders, Center for Epidemiologic Studies Depression (CES-D), SF-36, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Patient Health Questionnaire-9 (PHQ-9), neuropsychiatric, psychosis, neurologic involvement, neuropathy, peripheral nerves, cranial nerves, carpal tunnel syndrome, ulnar entrapment, tarsal tunnel syndrome, mononeuropathy, polyneuropathy, radiculopathy, myelopathy, autonomic nervous system, nervous system, electroencephalography (EEG), electromyography (EMG), magnetic resonance imaging (MRI), and magnetic resonance angiography (MRA). Patients with other connective tissue disease knowingly responsible for nervous system involvement were excluded from the analyses. A total of 182 case reports/studies addressing SSc and 50 referring to LS were identified. SSc patients totalized 9506, while data on 224 LS patients were available. In LS, seizures (41.58%) and headache (18.81%) predominated. Nonetheless, descriptions of varied cranial nerve involvement and hemiparesis were made. Central nervous system involvement in SSc was characterized by headache (23.73%), seizures (13.56%) and cognitive impairment (8.47%). Depression and anxiety were frequently observed (73.15% and 23.95%, respectively). Myopathy (51.8%), trigeminal neuropathy (16.52%), peripheral sensorimotor polyneuropathy (14.25%), and carpal tunnel syndrome (6.56%) were the most frequent peripheral nervous system involvement in SSc. Autonomic neuropathy involving cardiovascular and gastrointestinal systems was regularly described

  7. Parents’ Perceptions of Their Involvement in Schooling

    OpenAIRE

    Erdener, Mehmet Akif; Knoeppel, Robert C.

    2018-01-01

    Parent involvement has an influence on children’s educational engagementduring the elementary years. The objective of this study was to examine theperceptions of rural Turkish parents about their involvement in schooling withelementary school students based on Epstein’s (1995) six types of parentalinvolvement (parenting, communicating, volunteering, learning at home,decision-making, and collaborating with the community).  This study also investigated the differencesamong parent demographic ch...

  8. Patient empowerment and involvement in telemedicine

    DEFF Research Database (Denmark)

    Konge Nielsen, Marie; Johannessen, Helle

    2018-01-01

    Basic ideas of empowerment and user involvement in relation to telemedicine are presented, as is a case implying user resistance to telemedicine. Four logics of empowerment are employed to identify the underlying rationale of specific cases of telemedicine. The article concludes, that although...... telemedicine is acknowledged as relevant, the approach to it is often too mechanical to imply empowerment of the patient. Some patient groups may not feel safe by using telemedicine, and user involvement and empowerment will not be possible....

  9. Multiple Cranial Nerve Involvement In Cryptococcal Meningitis

    Directory of Open Access Journals (Sweden)

    Mahadevan A

    2000-01-01

    Full Text Available Cryptococcal meningitis is an uncommon cause of multiple cranial nerve palsies. This case report illustrates one such case of cryptococcal meningitis clinically manifesting with extensive cranial nerve involvement in an HIV seronegative individual. Histology revealed infiltration of the cranial nerves by cryptococci causing axonal disruption with secondary demyelination in the absence of any evidence of inflammation or vasculitis. We believe that axonal damage underlies the pathogenesis of cranial nerve involvement in cryptococcal meningitis.

  10. Ocular involvement in paediatric haemolytic uraemic syndrome.

    Science.gov (United States)

    Sturm, Veit; Menke, Marcel N; Landau, Klara; Laube, Guido F; Neuhaus, Thomas J

    2010-11-01

    The aim of this study was to estimate the frequency and severity of ocular involvement in paediatric patients with haemolytic uraemic syndrome (HUS). The study was designed as an institutional, retrospective, observational case series. Charts for all 87 paediatric patients with HUS treated at the University Children's Hospital Zurich between 1995 and 2007 were reviewed. Patients with ocular involvement were identified and clinical findings presented. Three of 69 examined patients with HUS showed ocular involvement. Ophthalmic findings in two children were consistent with bilateral Purtscher retinopathy, showing multiple haemorrhages, exudations and superficial retinal whitening. The third child presented with bilateral isolated central intraretinal haemorrhages as a milder form of ocular involvement. In one of the children with Purtscher retinopathy, laser photocoagulation was required for bilateral rubeosis irides and development of disc neovascularization. Longterm outcomes in the two severely affected children showed decreased visual acuity caused by partial atrophy of the optic nerves. In the milder case visual acuity was not impaired at any time. A minority of paediatric patients with HUS developed ocular involvement. Acute ocular findings varied in severity from isolated intraretinal haemorrhages to Purtscher-like retinopathy with retinal ischaemia. Longterm complications included the development of neovascularizations and consecutive optic nerve atrophy. Although ocular involvement in HUS seems to be rare, physicians should be aware of this complication because of its possible vision-endangering consequences. © 2009 The Authors. Journal compilation © 2009 Acta Ophthalmol.

  11. Lean Customer Involvement : A Multiple Case Study on the Effects of Kanban on Customer Involvement

    OpenAIRE

    Lundheim, Henning

    2012-01-01

    Customer involvement is an important, but challenging part of software development. Delays and failures can often be attributed to a lack of customer involvement. Different development methodologies provide different strategies for customer involvement, all with their own challenges. Kanban is a new development methodology quickly gaining popularity in the software development community. This thesis aims to answer the question: How does Kanban influence customer involvement? The main prob...

  12. Motivational Influences on Cognition: Task Involvement, Ego Involvement, and Depth of Information Processing.

    Science.gov (United States)

    Graham, Sandra; Golan, Shari

    1991-01-01

    Task involvement and ego involvement were studied in relation to depth of information processing for 126 fifth and sixth graders in 2 experiments. Ego involvement resulted in poorer word recall at deep rather than shallow information processing levels. Implications for the study of motivation are discussed. (SLD)

  13. Stakeholder involvement in Swedish nuclear waste management

    International Nuclear Information System (INIS)

    Elam, Mark; Sundqvist, Goeran

    2006-09-01

    This report concerning Swedish nuclear waste management has been produced as part of a cross national research project: CARL - A Social Science Research Project into the Effects of Stakeholder involvement on Decision-Making in Radioactive Waste Management. Besides Sweden, the participating countries are Belgium, Canada, Finland, Slovenia and United Kingdom. A social science research team, working for three years, is in the first phase conducting research in their own countries in order to produce 6 country reports. During the next years the focus will shift to comparisons of stakeholder involvement practices in the participating countries. The report addresses current practices of Swedish nuclear waste management and their historical development. The main focus is on past, current and emerging patterns of stakeholder involvement in the siting of a deep repository for the final disposal of Sweden's spent nuclear fuel. The general questions attended to in the report are: Who are the main stakeholders, and how have they emerged and gained recognition as such? What are the issues currently subject to stakeholder involvement and how have these been decided upon? How is stakeholder involvement organized locally and nationally and how has this changed over time? How has stakeholder involvement gained acceptance as an activity of value in the siting of major waste facilities? The report have attempted to show the development of stakeholder involvement in the siting of a final repository for Sweden's spent nuclear fuel as resembling something other than a straightforward linear process of improvement and refinement. Stakeholder involvement has developed, over the past 15 years or so, into something more like a patchwork of different shapes and forms. Some of the forces that may well contribute to the further elaboration of the patchwork of stakeholder involvement have been pointed out, contingently modifying once more its overall colour and orientation. Questions have been

  14. Stakeholder involvement in Swedish nuclear waste management

    Energy Technology Data Exchange (ETDEWEB)

    Elam, Mark; Sundqvist, Goeran [Goeteborg Univ. (Sweden). Section for Science and Technology Studies

    2006-09-15

    This report concerning Swedish nuclear waste management has been produced as part of a cross national research project: CARL - A Social Science Research Project into the Effects of Stakeholder involvement on Decision-Making in Radioactive Waste Management. Besides Sweden, the participating countries are Belgium, Canada, Finland, Slovenia and United Kingdom. A social science research team, working for three years, is in the first phase conducting research in their own countries in order to produce 6 country reports. During the next years the focus will shift to comparisons of stakeholder involvement practices in the participating countries. The report addresses current practices of Swedish nuclear waste management and their historical development. The main focus is on past, current and emerging patterns of stakeholder involvement in the siting of a deep repository for the final disposal of Sweden's spent nuclear fuel. The general questions attended to in the report are: Who are the main stakeholders, and how have they emerged and gained recognition as such? What are the issues currently subject to stakeholder involvement and how have these been decided upon? How is stakeholder involvement organized locally and nationally and how has this changed over time? How has stakeholder involvement gained acceptance as an activity of value in the siting of major waste facilities? The report have attempted to show the development of stakeholder involvement in the siting of a final repository for Sweden's spent nuclear fuel as resembling something other than a straightforward linear process of improvement and refinement. Stakeholder involvement has developed, over the past 15 years or so, into something more like a patchwork of different shapes and forms. Some of the forces that may well contribute to the further elaboration of the patchwork of stakeholder involvement have been pointed out, contingently modifying once more its overall colour and orientation. Questions

  15. [Xanthoma disseminatum with asymptomatic multisystem involvement].

    Science.gov (United States)

    Zinoun, M; Hali, F; Marnissi, F; Lazaar, S; Benchikhi, H

    2015-04-01

    Xanthogranulomas belong to non-Langerhans histiocytosis of the second group in the Histiocyte Society classification. They comprise a heterogeneous group of rare entities frequently involving cutaneous tropism. Xanthoma disseminatum belongs to this group of non-Langerhans histiocytosis. We report a case of xanthoma disseminatum (XD) in which localized skin and mucous impairment revealed multisystem involvement. A 28-year-old man presented with a two-year history of progressive yellow-orange and infiltrated xanthomatous papulonodular lesions of the face. Lesions of the oral mucosa and genital region were seen, with no functional repercussions. No ophthalmic or other complications were found. Histopathology showed a dense histiocytic infiltrate within the dermis with Touton giant cells, foamy multinucleated giant cells and inflammatory cells, without necrobiosis. Histiocytes were positive for CD68 but negative for CD1a. Gastric and lung involvement was seen and was confirmed at histology. Bone scintigraphy showed suspicious left ulnar hyperfixation suggesting bone involvement. No monoclonal gammopathy or diabetes insipidus was seen. Our patient was treated with corticosteroids 1mg/kg/day and thalidomide 100 mg/day. The outcome was marked by regression and exfiltration of the cutaneous lesions from the second week of treatment, with subsidence continuing at 3 months. This case involves a very rare form of xanthoma disseminatum. The localized facial skin lesions revealed multifocal non-Langerhans histiocytosis that was in fact asymptomatic. The diagnosis of XD was based on clinical, histological and immunohistochemical criteria. Xanthoma disseminatum is a non-Langerhans histiocytic proliferation first described by Montgomery in 1938. This rare entity is characterized by skin and mucous membrane xanthomatosis in which the facial involvement is common, together with diabetes insipidus and normal lipid metabolism. The prognosis is determined by the presence of mucosal

  16. [Pulmonary involvement in connective tissue disease].

    Science.gov (United States)

    Bartosiewicz, Małgorzata

    2016-01-01

    The connective tissue diseases are a variable group of autoimmune mediated disorders characterized by multiorgan damage. Pulmonary complications are common, usually occur after the onset of joint symptoms, but can also be initially presenting complaint. The respiratory system may be involved in all its component: airways, vessels, parenchyma, pleura and respiratory muscles. Lung involvement is an increasing cause of morbidity and mortality in the connective tissue diseases. Clinical course is highly variable - can range from mild to rapidly progressive, some processes are reversible, while others are irreversible. Thus, the identification of reversible disease , and separately progressive disease, are important clinical issues. The frequency, clinical presentation, prognosis and responce to therapy are different, depending on the pattern of involvement as well as on specyfic diagnostic method used to identify it. High- resolution computed tompography plays an important role in identifying patients with respiratory involvement. Pulmonary function tests are a sensitive tool detecting interstitial lung disease. In this article, pulmonary lung involvement accompanying most frequently apperaing connective tissue diseases - rheumatoid arthritis, systemic sclerosis, lupus erythematosus, polymyositis/dermatomyositis, Sjögrens syndrome and mixed connective tissue disaese are reviewed.

  17. Creating Learning at Conferences Through Participant Involvement

    DEFF Research Database (Denmark)

    Ravn, Ib; Elsborg, Steen

    as a forum for learning, mutual inspiration and "human co-flourishing." We offer five design principles that specify how conferences may involve participants more and hence increase their learning. In the research and development effort reported here, our team collaborated with conference organizers......The typical conference is brimming with PowerPoint presentations that leave very little time for participant involvement. Students of learning have long abandoned the transfer model that underlies this massive show of one-way communication. We propose an alternative theory of the conference...... in Denmark to introduce a variety of simple learning techniques related to the design principles at thirty real conferences of some 100-200 participants each. We present twelve of these techniques and the data evaluating them and conclude that by spending a fraction of the time at a conference on involving...

  18. Dual Headquarters Involvement in Subsidiary Innovation

    DEFF Research Database (Denmark)

    Dellestrand, Henrik; Kappen, Philip; Nell, Phillip Christopher

    2014-01-01

    The strategy and international business literature has identified the overall potential for headquarters to add value by allocating resources to subsidiary activities, but little is known about the extent to which multiple headquarters simultaneously involves itself in subsidiary operations....... The current paper takes on this neglected question by empirically investigating corporate and divisional headquarters direct involvement in innovation development projects at the subsidiary level. Analyses that draw upon 85 innovation development projects in 23 multinational enterprises reveal that dual...... of the developing subsidiary positively moderates the two aforementioned effects on dual headquarters involvement in innovation development. The results lend support for the notion that parenting in complex structures entails complex headquarters structures. Thus, the results question simplistic views...

  19. Meningeal involvement in Behcet's disease: MRI

    International Nuclear Information System (INIS)

    Guma, A.; Aguilera, C.; Pons, L.; Acebes, J.; Arruga, J.

    1998-01-01

    Behcet's disease is a multisystem disease that involves the central nervous system up to half of cases. Presentation with neurologic symptoms occurs in 5 % of cases and cerebral venous thrombosis is one of its major manifestations. A feature not previously reported is progressive meningeal thickening with involvement of both optic nerves. We report a patient with cerebral venous thrombosis, meningeal thickening and contrast enhancement on MRI. This patient had two other unusual features: positive antineutrophil cytoplasmic antibodies and later development of central diabetes insipidus. (orig.)

  20. Peer Involvement in University Students' Education

    Directory of Open Access Journals (Sweden)

    Zlatka Cugmas

    2016-12-01

    Full Text Available We investigated the correlations between peer involvement in students’ education and their self-perception, attachment style, relationships with peers, personality and well-being. We used the Inventory of parent and peer attachment (Armsden & Greenberg, 1987, Relationship questionnaire (Bartholomew & Horowitz, 1991, Questionnaire of the subjects’ self-perceptions (Cugmas, 2012 and The big five questionnaire (BFQ; Caprara et al, 2002. We developed the questionnaires of peer involvement and subjects’ well-being. Positive relationships with peers, secure attachment style, positive self-perceptions, some personal characteristics and well-being were positively associated with peer support, and negatively with peer pressure.

  1. Canadian involvement in international nuclear cooperation

    International Nuclear Information System (INIS)

    Jennekens, Jon.

    1981-01-01

    Since 1945 Canada has been actively involved in the development of an international consensus on measures to prevent the proliferation of nuclear weapons. In parallel with this involvement, Canada has entered into cooperation agreements with several countries under which nuclear materials, equipment and facilities have been supplied in connection with the medical, industrial, agricultural and electrical power applications of nuclear energy. This paper summarizes the actions taken by Canada to encourage the peaceful uses of nuclear energy and to avoid the spread of nuclear weapons [fr

  2. Langerhans Cell Histiocytosis Involving Maxilla and Mandible

    Directory of Open Access Journals (Sweden)

    M. Guna Shekhar

    2009-06-01

    Full Text Available Langerhans cell histiocytosis is a relatively rare unique disease process characterized by an abnormal proliferation of immature dendritic cells usually affecting children and young adults. Jaws are involved in less than 10% of children with the disease while mandibular involvement in young children is uncommon and bilateral affection is very rare. The purpose of this report is to describe a unique and very rare case of simultaneous and bilateral occurrence of Langerhans cell histiocytosis in both the jaws of a four-year-old boy.

  3. Canadian involvement in international nuclear cooperation

    International Nuclear Information System (INIS)

    Jennekens, J.

    1981-01-01

    Since 1945 Canada has been actively involved in the development of an international consensus on measures to prevent the proliferation of nuclear weapons. In parallel with this involvement, Canada has entered into cooperative agreements with several countries under which nuclear materials, equipment and facilities have been supplied in connection with the medical, industrial, agricultural and electrical power applications of nuclear energy. This paper summarizes the actions taken by Canada to encourage the peaceful uses of nuclear energy and to avoid the spread of nuclear weapons. (author)

  4. Justification of novel practices involving radiation exposure

    International Nuclear Information System (INIS)

    Webb, G.; Boal, T.; Mason, C.; Wrixon, T.

    2006-01-01

    The concept of 'justification' of practices has been one of the three basic principles of radiation protection for many decades. The principle is simple in essence - that any practice involving radiation exposure should do more good than harm. There is no doubt that the many uses of radiation in the medical field and in industry generally satisfy this principle, yielding benefits that could not be achieved using other techniques; examples include CT scanning and industrial radiography. However, even in the early period after the introduction of the justification principle, there were practices for which the decision on justification was not clear and for which different decisions were made by the authorities in different countries. Many of these involved consumer products such as luminous clocks and watches, telephone dials, smoke detectors, lightning preventers and gas mantles. In most cases, these practices were relatively small scale and did not involve large exposures of either individual workers or members of the public. Decisions on justification were therefore often made by the regulator without extensive national debate. Over recent years, several practices have been proposed and undertaken that involve exposure to radiation for purposes that were generally not envisaged when the current system of radiation protection was created. Some of these practices were reviewed during a recent symposium held in Dublin, Ireland and involve, for example, the x-raying of people for theft detection purposes, for detection of weapons or contraband, for the prediction of physical development of young athletes or dancers, for age determination, for insurance purposes and in cases of suspected child abuse. It is particularly in the context of such novel practices that the need has emerged for clearer international guidance on the application of the justification principle. This paper reviews recent activities of the IAEA with respect to these issues, including the

  5. Justification of novel practices involving radiation exposure

    Energy Technology Data Exchange (ETDEWEB)

    Webb, G. [Radiation Protection Consul tant, Brighton (United Kingdom); Boal, T.; Mason, C.; Wrixon, T. [International Atomic Energy Agency, Vienna (Austria)

    2006-07-01

    The concept of 'justification' of practices has been one of the three basic principles of radiation protection for many decades. The principle is simple in essence - that any practice involving radiation exposure should do more good than harm. There is no doubt that the many uses of radiation in the medical field and in industry generally satisfy this principle, yielding benefits that could not be achieved using other techniques; examples include CT scanning and industrial radiography. However, even in the early period after the introduction of the justification principle, there were practices for which the decision on justification was not clear and for which different decisions were made by the authorities in different countries. Many of these involved consumer products such as luminous clocks and watches, telephone dials, smoke detectors, lightning preventers and gas mantles. In most cases, these practices were relatively small scale and did not involve large exposures of either individual workers or members of the public. Decisions on justification were therefore often made by the regulator without extensive national debate. Over recent years, several practices have been proposed and undertaken that involve exposure to radiation for purposes that were generally not envisaged when the current system of radiation protection was created. Some of these practices were reviewed during a recent symposium held in Dublin, Ireland and involve, for example, the x-raying of people for theft detection purposes, for detection of weapons or contraband, for the prediction of physical development of young athletes or dancers, for age determination, for insurance purposes and in cases of suspected child abuse. It is particularly in the context of such novel practices that the need has emerged for clearer international guidance on the application of the justification principle. This paper reviews recent activities of the IAEA with respect to these issues, including the

  6. Customer Involvement in the Game Development Process

    Directory of Open Access Journals (Sweden)

    Kaja Prystupa-Rządca

    2015-01-01

    Full Text Available The creative industry is a fast developing sector of economy in many countries. Growing competition in this area has led many companies to implement strategy of users' involvement in product development in order to deliver products that are more aligned with customers’ needs. On the other hand, the attempt to align the customers’ expectations with artistic creativity may create tensions. Therefore, the aim of the research is to examine the methods of users’ involvement in product development and real impact of the users on project design. The obtained findings are based on two-year qualitative research project conducted in game development companies.

  7. Involving Customer Relations in Contextual Design

    DEFF Research Database (Denmark)

    Simonsen, Jesper

    1996-01-01

    This paper presents a case study in the form of a contextual design project, the aim of which was to design a system for a particular organization. The starting point in the case was a need in the organization for a specific system. The case involved an analysis of the organizations customer...... point of the design project, how the project was conducted, and which results it ended up with. This is followed by a discussion of the effects of, and lessons learned by, involving customer relations in contextual design....

  8. Spinal cord involvement in tuberculous meningitis.

    Science.gov (United States)

    Garg, R K; Malhotra, H S; Gupta, R

    2015-09-01

    To summarize the incidence and spectrum of spinal cord-related complications in patients of tuberculous meningitis. Reports from multiple countries were included. An extensive review of the literature, published in English, was carried out using Scopus, PubMed and Google Scholar databases. Tuberculous meningitis frequently affects the spinal cord and nerve roots. Initial evidence of spinal cord involvement came from post-mortem examination. Subsequent advancement in neuroimaging like conventional lumbar myelography, computed tomographic myelography and gadolinium-enhanced magnetic resonance-myelography have contributed immensely. Spinal involvement manifests in several forms, like tuberculous radiculomyelitis, spinal tuberculoma, myelitis, syringomyelia, vertebral tuberculosis and very rarely spinal tuberculous abscess. Frequently, tuberculous spinal arachnoiditis develops paradoxically. Infrequently, spinal cord involvement may even be asymptomatic. Spinal cord and spinal nerve involvement is demonstrated by diffuse enhancement of cord parenchyma, nerve roots and meninges on contrast-enhanced magnetic resonance imaging. High cerebrospinal fluid protein content is often a risk factor for arachnoiditis. The most important differential diagnosis of tuberculous arachnoiditis is meningeal carcinomatosis. Anti-tuberculosis therapy is the main stay of treatment for tuberculous meningitis. Higher doses of corticosteroids have been found effective. Surgery should be considered only when pathological confirmation is needed or there is significant spinal cord compression. The outcome in these patients has been unpredictable. Some reports observed excellent recovery and some reported unfavorable outcomes after surgical decompression and debridement. Tuberculous meningitis is frequently associated with disabling spinal cord and radicular complications. Available treatment options are far from satisfactory.

  9. Involving IDPs in the Darfur peace process

    Directory of Open Access Journals (Sweden)

    David Lanz

    2008-04-01

    Full Text Available The UN estimates that there are 2.4 millionIDPs in Darfur –over one third of the totalpopulation. There can be no meaningfulpeace process without their involvement.Giving IDPs a formal seat in official peacenegotiations is problematic but there areother ways to ensure their participation.

  10. Involving Families and Community through Gardening

    Science.gov (United States)

    Starbuck, Sara; Olthof, Maria

    2008-01-01

    Gardens are complex and require a variety of skills. Gross- and fine-motor activities, science concepts, language and literacy development, math, and community involvement are all part of the preschool gardening project the authors describe. They list gardening books for children and suggest container gardens for urban school settings. The authors…

  11. Interdisciplinary Collaboration: Librarian Involvement in Grant Projects

    Science.gov (United States)

    Brandenburg, Marci D.; Cordell, Sigrid Anderson; Joque, Justin; MacEachern, Mark P.; Song, Jean

    2017-01-01

    Librarians are excellent research collaborators, although librarian participation is not usually considered, thereby making access to research funds difficult. The University of Michigan Library became involved in the university's novel funding program, MCubed, which supported innovative interdisciplinary research on campus, primarily by funding…

  12. Parent Involvement, Technology, and Media: Now What?

    Science.gov (United States)

    Patrikakou, Eva N.

    2016-01-01

    The rapid technological advances, the expansion of online media use, and the declining cost of mobile technology have introduced a communication factor that has precipitously affected parent involvement and the relationship between parents and children. The present article explores ways through which technology and online media have affected…

  13. Crossing boundaries : Involving external parties in innovation

    NARCIS (Netherlands)

    Slot, J.H.

    2013-01-01

    To improve the return on investments in innovation, firms increasingly open up their new product development (NPD) processes by inviting external parties to participate. This dissertation focuses on the involvement of three different types of external parties in the NPD process: suppliers,

  14. Mergers and acquisitions involving equine veterinary practices.

    Science.gov (United States)

    Jackman, Brad R; McCafferty, Owen E

    2009-12-01

    This article discusses mergers and acquisitions involving equine veterinary practices. Combining practices can be professionally and economically advantageous but requires a great deal of thought, planning, and implementation. If due diligence is performed and true business teamwork is undertaken, the benefits can be enormous and rewarding.

  15. Games and gambling involvement among casino patrons.

    Science.gov (United States)

    LaPlante, Debi A; Afifi, Tracie O; Shaffer, Howard J

    2013-06-01

    A growing literature is addressing the nature of the relationships among gambling activity, gambling involvement, and gambling-related problems. This research suggests that among the general population, compared to playing any specific game, gambling involvement is a better predictor of gambling-related problems. To date, researchers have not examined these relationships among casino patrons, a population that differs from the general population in a variety of important ways. A survey of 1160 casino patrons at two Las Vegas resort casinos allowed us to determine relationships between the games that patrons played during the 12 months before their casino visit, the games that patrons played during their casino visit, and patrons' self-perceived history of gambling-related problems. Results indicate that playing specific gambling games onsite predicted (i.e., statistically significant odds ratios ranging from .5 to 4.51) self-perceived gambling-related problems. However, after controlling for involvement, operationally defined as the number of games played during the current casino visit and self-reported gambling frequency during the past 12 months, the relationships between games and gambling-related problems disappeared or were attenuated (i.e., odds ratios no longer statistically significant). These results extend the burgeoning literature related to gambling involvement and its relationship to gambling-related problems.

  16. Disseminated cutaneous histoplasmosis with laryngeal involvement ...

    African Journals Online (AJOL)

    Disseminated cutaneous histoplasmosis with laryngeal involvement in a setting of immune reconstitution inflammatory syndrome. ... Grocott-Gomori methenamine silver and Periodic acid–Schiff (PAS) stains revealed a relative paucity of intracellular, narrow-neck budding fungal organisms. Culture findings confirmed the ...

  17. The Personal Meaning of Participation: Enduring Involvement.

    Science.gov (United States)

    McIntyre, N.

    1989-01-01

    Examines the personal meaning of participation, discussing recreation and consumer behavior literature, the development of an instrument to measure the concept, and the relationship between commitment to camping and choice of campground setting. Personal meaning of participation seems to be best represented by the concept of enduring involvement.…

  18. Reassessing the structure of enduring leisure involvement

    Science.gov (United States)

    Jinhee Jun; Gerard T. Kyle; Symeon P. Vlachopoulos; Nicholas D. Theodorakis; James D. Absher; William E. Hammitt

    2012-01-01

    Using data collected from U.S. and Greek respondents, we tested an alternate conceptualization of enduring leisure involvement where identity was considered a key driver of other affective and conative outcomes. Rather than existing on the same temporal plane, as has been the tradition in the leisure literature, we observed that identity was an antecedent of the other...

  19. Is Parental Involvement Lower at Larger Schools?

    Science.gov (United States)

    Walsh, Patrick

    2010-01-01

    Parents who volunteer, or who lobby for improvements in school quality, are generally seen as providing a school-wide public good. If so, straightforward public-good theory predicts that free-riding will reduce average involvement at larger schools. This study uses longitudinal data to follow families over time, as their children move from middle…

  20. Trucks involved in fatal accidents codebook 2008.

    Science.gov (United States)

    2011-01-01

    This report provides documentation for UMTRIs file of Trucks Involved in Fatal Accidents : (TIFA), 2008, including distributions of the code values for each variable in the file. The 2008 : TIFA file is a census of all medium and heavy trucks invo...

  1. Spinal cord involvement in Balo's concentric sclerosis

    NARCIS (Netherlands)

    Kreft, Karim L.; Mellema, S. Jouke; Hintzen, Rogier Q.

    2009-01-01

    We present a patient with a history of myelitis, who had a steroid refractory attack of CNS inflammatory demyelinating disease that developed into cerebral concentric sclerosis of Balo after plasma exchange. The acute inflammatory disease involved the spinal cord, a phenomenon rarely demonstrated.

  2. Involvement of methyltransferases enzymes during the energy ...

    African Journals Online (AJOL)

    The methyl group transfer from dimethylsulfide (DMS), trimethylamine and methanol to 2-mercaptoethanesulfonic acid (coenzyme M) were investigated from cell extracts of Methanosarcina semesiae sp. nov. to evaluate whether the enzyme systems involved were constitutive or inductive. The extracts from cells grown on ...

  3. Epiphyseal involvement in unicameral bone cysts

    International Nuclear Information System (INIS)

    Capanna, R.; Ruggieri, P.; Biagini, R.; Horn, J. van

    1986-01-01

    Twelve patients are reported in whom a unicameral bone cyst was found to involve the epiphysis or apophysis across an open growth plate. Nine patients showed pathologic fracture. In four patients a growth disturbance was found. A varying amount of varus angulation was present in most cases. No patient had functional impairment. (orig.)

  4. Epiphyseal involvement in unicameral bone cysts

    Energy Technology Data Exchange (ETDEWEB)

    Capanna, R.; Ruggieri, P.; Biagini, R.; Horn, J. van

    1986-08-01

    Twelve patients are reported in whom a unicameral bone cyst was found to involve the epiphysis or apophysis across an open growth plate. Nine patients showed pathologic fracture. In four patients a growth disturbance was found. A varying amount of varus angulation was present in most cases. No patient had functional impairment.

  5. Comparison of Learner Involvement in Biology Laboratory ...

    African Journals Online (AJOL)

    Performance in the biology practical paper has been poor at Kenya national examinations in the past five years (1998-2002). This may imply a lack of emphasis on the teaching of biology through the process-based approach. This study investigated the level of learner involvement in biology practical investigations in ...

  6. Exploring genes and pathways involved in migraine

    NARCIS (Netherlands)

    Eising, E.

    2017-01-01

    The research in this thesis was aimed at identifying genes and molecular pathways involved in migraine. To this end, two gene expression analyses were performed in brain tissue obtained from transgenic mouse models for familial hemiplegic migraine (FHM), a monogenic subtype of migraine with aura.

  7. Family involvement and helping behavior in teams

    NARCIS (Netherlands)

    Brummelhuis, L.L. ten; Lippe, A.G. van der; Kluwer, E.S.

    2010-01-01

    Helping behavior at work has become increasingly important, with organizations making more and more use of cooperative work practices. The difficulty is that employees are facing growing demands beyond the workplace. This study investigates the mechanisms by which family involvement ( family

  8. Family involvement and helping behaviour in teams

    NARCIS (Netherlands)

    Brummelhuis, L.L. ten; Lippe, T. van der; Kluwer, E.S.

    2010-01-01

    Helping behavior at work has become increasingly important, with organizations making more and more use of cooperative work practices. The difficulty is that employees are facing growing demands beyond the workplace. This study investigates the mechanisms by which family involvement (family

  9. Job Involvement And Organizational Climate | MOGAJI | IFE ...

    African Journals Online (AJOL)

    This study was aimed at finding the relationship between job involvement and organizational climate. Data were collected from 600 subjects which include 150 junior workers (120 males and 30 females), 30 supervisors (27 males and 3 females) and 20 managers (18 males and 2 females) totalling 200 subjects from each of ...

  10. Motivation and involvement toward physical activity among ...

    African Journals Online (AJOL)

    This study investigates intrinsic and extrinsic factors that influence involvement of university students to participate in physical activity. 400 students comprising 200 men and 200 women were used as the main respondents were respond to the adapted Exercise Motivations Inventory questionnaire. It revealed that highest ...

  11. Student Involvement in Learning and School Achievement.

    Science.gov (United States)

    Anderson, Lorin W.

    The purpose of the study was to investigate the relationship between selected student characteristics, student involvement in learning, and achievement. Both naturalistic (n = 28, 27) and experimental studies were conducted. In the experimental study, two classes (n = 29, 26) learned a sequence of matrix arithmetic by mastery learning strategies.…

  12. Learning models of activities involving interacting objects

    DEFF Research Database (Denmark)

    Manfredotti, Cristina; Pedersen, Kim Steenstrup; Hamilton, Howard J.

    2013-01-01

    We propose the LEMAIO multi-layer framework, which makes use of hierarchical abstraction to learn models for activities involving multiple interacting objects from time sequences of data concerning the individual objects. Experiments in the sea navigation domain yielded learned models that were t...

  13. Analytical solution of population balance equation involving ...

    Indian Academy of Sciences (India)

    This paper presents an effective analytical simulation to solve population balance equation (PBE), involving particulate aggregation and breakage, by making use ... The domain part of the email address of all email addresses used by the office of Indian Academy of Sciences, including those of the staff, the journals, various ...

  14. Overview of airway involvement in tuberculosis

    International Nuclear Information System (INIS)

    Arora, Arundeep; Bhalla, Ashu Seith; Jana, Manisha; Sharma, Raju

    2013-01-01

    Pulmonary tuberculosis is a ubiquitous infection and a re-emerging medical and socioeconomic problem resulting in increasing mortality and morbidity, especially in Asian countries. We aim to review the spectrum of imaging findings in airway involvement in tuberculosis through characteristic radiological images and to assess the role of computed tomography and image-guided interventions in the diagnosis and management of pulmonary tuberculosis.

  15. Community Involvement in School Management in Portugal

    Science.gov (United States)

    Veloso, Luísa; Craveiro, Daniela; Rufino, Isabel

    2013-01-01

    This article discusses the ways in which the community is involved in Portuguese school management. It is based on an analysis of the external evaluation reports of 298 Portuguese schools for the academic years 2006-07, 2007-08 and 2008-09. The corpus analysed allowed the identification of two main aspects of the participation processes: (1) local…

  16. Involvement of Students in E-Learning

    Science.gov (United States)

    Al Ya, Marwa; Aziz, Sheikha A.; Mohyuddin, Muhammad Raheel; Al Balushi, Nabila

    2017-01-01

    The involvement of E-learning activities for students in the classroom play an important role in the teaching and learning process. In this paper, the authors describe how we collected information from 3-different Colleges/Universities in Oman forming an online study with regard to the use of internet, e-library, online book access, and…

  17. Choice, Empowerment, and Involvement: What Satisfies Parents?

    Science.gov (United States)

    Goldring, Ellen B.; Shapira, Rina

    1993-01-01

    Questionnaire responses from 337 parents in Israel examine the nature of interrelationships between parent satisfaction with public schools of choice and parent empowerment, parent involvement, and the congruence of parental expectation with school programs. Findings indicate the importance of socioeconomic status as a factor in these…

  18. Relative Effects of Psychological Flexibility, Parental Involvement ...

    African Journals Online (AJOL)

    A critical analysis and understanding of secondary students' experiences and of safety in public schools are currently lacking in the literature and warrant further research. This study investigated the relative effects of psychological flexibility, parental involvement and school climate on secondary school student's school ...

  19. Endotoxin content in endodontically involved teeth. 1975.

    Science.gov (United States)

    Schein, Benjamin; Schilder, Herbert

    2006-04-01

    Fluid was aspirated from the root canals of 40 endodontically involved teeth. This fluid was assayed for endotoxin with the limulus lysate test. Pulpless teeth contained greater concentrations of endotoxin than those with vital pulps. Symptomatic teeth also contained more endotoxin than asymptomatic teeth.

  20. Czech Companies Involved in the ARTEMIS Programme

    Czech Academy of Sciences Publication Activity Database

    Kadlec, Jiří

    -, special issue (2013), s. 4-5 ISSN 1210-9592 R&D Projects: GA MŠk(CZ) LE13020 Keywords : ARTEMIS JU * embedded systems * european technology platforms * FP7 * ICT * microelectronics * ENIAC JU Subject RIV: AF - Documentation, Librarianship, Information Studies http://library.utia.cas.cz/separaty/2013/ZS/kadlec-czech companies involved in the artemis programme.pdf

  1. 78 FR 27339 - Private Attorney Involvement

    Science.gov (United States)

    2013-05-10

    ... Pro Bono Task Force identified the benefits of integrated intake and referral systems that link... volunteers, the Pro Bono Task Force recommended that the resources the recipient uses to support the training... Involvement (PAI) rule to respond to Recommendation 2 of LSC's Pro Bono Task Force Report. The discussions in...

  2. Isolated posterior fossa involvement of progressive multifocal ...

    African Journals Online (AJOL)

    2017-11-14

    Nov 14, 2017 ... and the HIV pandemic has resulted in an increased prevalence of PML, affecting 3% – 7% of HIV- infected ... majority of HIV-infected patients with PML have CD4 lymphocyte counts < 200 cells/mm3. JC ... infrequent contrast enhancement.3 There is no involvement of the optic nerves or spinal cord. Isolated ...

  3. Temporomandibular joint involvement in psoriatic arthritis | Okkesim ...

    African Journals Online (AJOL)

    Psoriasis is a chronic, papulosquamous, and an inflammatory skin disease. It has been found that between 5% and 24% of patients develop psoriatic arthritis (PA) at the same time after or even prior to skin findings. The involvement of temporomandibular joint (TMJ) is a rare condition. In this report, a-46-year-old male ...

  4. Parental Involvement in Children's Independent Music Lessons

    Science.gov (United States)

    Upitis, Rena; Abrami, Philip C.; Brook, Julia; King, Matthew

    2017-01-01

    The purpose of the study was to examine types of parental involvement associated with independent music lessons. A self-report survey was designed to explore parent characteristics, parental goals, students' musical progress, the teacher-student relationship, the practice environment, and parent behaviours during practice sessions. The extent to…

  5. Local identities involving Jacobi elliptic functions

    Indian Academy of Sciences (India)

    systematize the local identities by deriving four local 'master identities' analogous to the ... involving Jacobi elliptic functions can be explicitly evaluated and a number of .... most of these integrals do not seem to be known in the literature. In §6 ...

  6. [Cardiac involvement in Churg-Strauss syndrome].

    Science.gov (United States)

    Brucato, Antonio; Maestroni, Silvia; Masciocco, Gabriella; Ammirati, Enrico; Bonacina, Edgardo; Pedrotti, Patrizia

    2015-09-01

    Churg-Strauss syndrome, recently renamed eosinophilic granulomatosis with polyangiitis (EGPA), is a rare form of systemic vasculitis, characterized by disseminated necrotizing vasculitis with extravascular granulomas occurring among patients with asthma and tissue eosinophilia. EGPA is classified as a small and medium-sized vessel vasculitis associated with antineutrophil cytoplasmic antibodies (ANCA) and the hypereosinophilic syndrome. Typical clinical features include asthma, sinusitis, transient pulmonary infiltrates and neuropathy. Blood eosinophils are often >1500/µl or more than 10% on the differential leukocyte count. Blood eosinophils should always be tested in unexplained cardiac disorders, and may normalize even after low doses of corticosteroids. ANCA are positive in 40-60% of cases, mainly anti-myeloperoxidase. Heart involvement occurs in approximately 15-60% of EGPA patients, especially those who are ANCA negative. Any cardiac structure can be involved, and patients present with myocarditis, heart failure, pericarditis, arrhythmia, coronary arteritis, valvulopathy, intracavitary cardiac thrombosis. Although cardiovascular involvement is usually an early manifestation, it can also occur later in the course of the disease. A significant proportion of patients with cardiac involvement is asymptomatic. In the absence of symptoms and major ECG abnormalities, cardiac involvement may be detected in nearly 40% of the patients. All patients with EGPA should be studied not only with a detailed history of cardiac symptoms and ECG, but also with echocardiography; if abnormalities are detected, a cardiac magnetic resonance study should be performed. Coronary angiography and endomyocardial biopsy should be reserved to selected cases. Heart involvement carries a poor prognosis and causes 50% of the deaths of these patients. It is often insidious and underestimated. Optimal therapy is therefore important and based on high-dose corticosteroids plus immunosuppressive

  7. Stakeholder Involvement in Swedish Nuclear Waste Management

    International Nuclear Information System (INIS)

    Elam, Mark; Sundqvist, Goeran

    2006-01-01

    The focus in this paper is on past, current and emerging patterns of stakeholder involvement in the siting of a deep repository for final disposal of Sweden's spent nuclear fuel. In particular, we concentrate on how the two municipalities of Oskarshamn and Oesthammar have acted as engaged stakeholders, and have gained recognition as such, in the siting process. In general: How has stakeholder involvement gained acceptance as an activity of value in the siting of major waste facilities? What are the issues currently subject to stakeholder involvement and how have these been decided upon? An effect of the history of nuclear activity in Oskarshamn and Oesthammar is that stakeholder involvement over a final repository can be divided into social and technical issues. Both municipalities have out of tradition, as part of their social acceptance of a new repository, been prepared to surrender extended involvement in key safety issues. They have been prepared to do this because they also see themselves being able to delegate these safety issues to the government authorities SSI and SKI. These two authorities have been acceptable to the two municipalities as their legitimate 'technological guardians'. As physical geology re-enters the siting process for a deep repository, Oskarshamn appear more prepared to break with tradition than Oesthammar. Oskarshamn are currently demanding transparency from SKB in relation to the exact technical and geological criteria they will use to choose between them and Oesthammar as a repository site. In contrast to Oesthammar, Oskarshamn are preparing with the expected help of SKI and SSI to dispute their geology and its relation to nuclear safety with SKB if they consider it necessary. If Oskarshamn act to draw safety issues in relation to alternative methods and sitings into the EIA process where might this lead? As environmental groups now enter the process (three groups were granted funding in the first round - 2005) the character of site

  8. Involving patients with E-health

    DEFF Research Database (Denmark)

    Nielsen, Karen Dam

    2015-01-01

    With e-health technologies, patients are invited as co-producers of data and information. The invitation sparks new expectations, yet often results in disappointments. With persistent ambitions to involve patients by means of e-health, it seems crucial to gain a better understanding of the nature......, sources and workings of the expectations that come with being invited. I analyse the use of an e-health system for ICD-patients, focusing on how patients sought to serve as information providers. Continuing STS-research on invisible work in technology use, I show how using the system involved complex work...... that understanding the dialogic dynamics and ‘overflows’ of information filtration work can help unpack the challenges of facilitating (patient) participation with e-health and other filtration devices....

  9. Understanding and encouraging volunteerism and community involvement.

    Science.gov (United States)

    Stukas, Arthur A; Snyder, Mark; Clary, E Gil

    2016-01-01

    Volunteerism and community involvement have been demonstrated to offer benefits both to communities and to volunteers themselves. However, not every method to encourage these behaviors is equally effective in producing committed volunteers. Drawing on relevant theoretical and empirical literatures, we identify features of efforts that are likely to produce intrinsically motivated other-oriented volunteers and those that may produce extrinsically motivated self-oriented volunteers. In particular, we explore ways to socialize young people to help and ways to build a sense of community focused on particular issues. We also examine requirements for community service and other approaches that highlight self-oriented benefits that volunteers may obtain. Finally, we return to a focus on the importance of intrinsic motivation for promoting sustained involvement in volunteers, even as we acknowledge that volunteers who come with extrinsic or self-oriented reasons can still offer much to communities and can be satisfied when their activities match their motivations.

  10. Public involvement in environmental surveillance at Hanford

    International Nuclear Information System (INIS)

    Hanf, R.W. Jr.; Patton, G.W.; Woodruff, R.K.; Poston, T.M.

    1994-08-01

    Environmental surveillance at the Hanford Site began during the mid-1940s following the construction and start-up of the nation's first plutonium production reactor. Over the past approximately 45 years, surveillance operations on and off the Site have continued, with virtually all sampling being conducted by Hanford Site workers. Recently, the US Department of Energy Richland Operations Office directed that public involvement in Hanford environmental surveillance operations be initiated. Accordingly, three special radiological air monitoring stations were constructed offsite, near hanford's perimeter. Each station is managed and operated by two local school teaches. These three stations are the beginning of a community-operated environmental surveillance program that will ultimately involve the public in most surveillance operations around the Site. The program was designed to stimulate interest in Hanford environmental surveillance operations, and to help the public better understand surveillance results. The program has also been used to enhance educational opportunities at local schools

  11. Spin versus helicity in processes involving transversity

    CERN Document Server

    Mekhfi, Mustapha

    2011-01-01

    We construct the spin formalism in order to deal in a direct and natural way with processes involving transversity which are now of increasing popularity. The helicity formalism which is more appropriate for collision processes of definite helicity has been so far used also to manage processes with transversity, but at the price of computing numerous helicity amplitudes generally involving unnecessary kinematical variables.In a second step we work out the correspondence between both formalisms and retrieve in another way all results of the helicity formalism but in simpler forms.We then compute certain processes for comparison.A special process:the quark dipole magnetic moment is shown to be exclusively treated within the spin formalism as it is directly related to the transverse spin of the quark inside the baryon.

  12. Endoplasmic reticulum involvement in yeast cell death

    International Nuclear Information System (INIS)

    Nicanor Austriaco, O.

    2012-01-01

    Yeast cells undergo programed cell death (PCD) with characteristic markers associated with apoptosis in mammalian cells including chromatin breakage, nuclear fragmentation, reactive oxygen species generation, and metacaspase activation. Though significant research has focused on mitochondrial involvement in this phenomenon, more recent work with both Saccharomyces cerevisiae and Schizosaccharomyces pombe has also implicated the endoplasmic reticulum (ER) in yeast PCD. This minireview provides an overview of ER stress-associated cell death (ER-SAD) in yeast. It begins with a description of ER structure and function in yeast before moving to a discussion of ER-SAD in both mammalian and yeast cells. Three examples of yeast cell death associated with the ER will be highlighted here including inositol starvation, lipid toxicity, and the inhibition of N-glycosylation. It closes by suggesting ways to further examine the involvement of the ER in yeast cell death.

  13. Involving stakeholders in evaluating environmental restoration technologies

    International Nuclear Information System (INIS)

    McCabe, G.H.; Serie, P.J.

    1993-02-01

    Involving citizens, interest groups, and regulators in environmental restoration and waste management programs is a challenge for government agencies and the organizations that support them. To be effective, such involvement activities must identify all individuals and groups who have a stake in the cleanup. Their participation must be early, substantive, and meaningful. Stockholders must be able to see how their input was considered and used, and feel that a good- faith effort was made to reconcile conflicting objectives. The Integrated Demonstration for Cleanup of Volatile Organic Compounds at Arid Sites (VOC-Arid ID) is a Department of Energy Office of Technology Development project located at Hanford. Along with technical evaluation of innovative cleanup technologies, the program is conducting an institutional assessment of regulatory and public acceptance of new technologies. Through a series of interviews and workshops, and use of a computerized information management tool, stakeholders are having a voice in the evaluation. Public and regulatory reaction has been positive

  14. Cortical areas involved in Arabic number reading.

    Science.gov (United States)

    Roux, F-E; Lubrano, V; Lauwers-Cances, V; Giussani, C; Démonet, J-F

    2008-01-15

    Distinct functional pathways for processing words and numbers have been hypothesized from the observation of dissociated impairments of these categories in brain-damaged patients. We aimed to identify the cortical areas involved in Arabic number reading process in patients operated on for various brain lesions. Direct cortical electrostimulation was prospectively used in 60 brain mappings. We used object naming and two reading tasks: alphabetic script (sentences and number words) and Arabic number reading. Cortical areas involved in Arabic number reading were identified according to location, type of interference, and distinctness from areas associated with other language tasks. Arabic number reading was sustained by small cortical areas, often extremely well localized (area (Brodmann area 45), the anterior part of the dominant supramarginal gyrus (Brodmann area 40; p area (Brodmann area 37; p areas.

  15. [Parotid involvement in Churg-Strauss syndrome].

    Science.gov (United States)

    Bonnet, R; Bertin, H; Delemazure, A S; Clairand, R; Mercier, J; Corre, P

    2014-06-01

    Churg-Strauss syndrome is a rare systemic vascularitis. This disease causes eosinophilic tissue infiltration. The most frequent manifestations are cortico-dependent asthma, mono- or polyneuropathy, paranasal sinus polyposis, and digestive and renal dysfunction. Salivary glands are very rarely involved. We describe a case of CSS in a patient presenting with bilateral parotid swelling. The morphological study of salivary glands revealed an unusual thickening of the salivary duct walls. Salivary gland involvement in Churg and Strauss syndrome can be difficult to demonstrate histologically; it does not usually present in the clinical foreground of the disease, and can be a source of misdiagnosis. The biopsy should be performed in the symptomatic gland, away from any previous corticoid treatment. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  16. Occupational risk involving students of health

    Directory of Open Access Journals (Sweden)

    Éder Oliveira Rocha

    2014-01-01

    Full Text Available Objective: To analyze the social representations of occupational risks involving students in the area of health. Method: Exploratory research with 160 students from nursing, medicine and dentistry, through interviews. The data were processed in ALCESTE 4.8 and lexical analysis done by descending hierarchical classification. Results: In four semantic classes, namely: occupational risks involving students in the area of health, the work environment and occupational risks, exposure to accidents with sharps and adoption of standard precautions as biosecurity measures. Conclusion: Students healthcare represent occupational risks, such as a concern for the prevention of cross infection in the workplace, should both professionals and students of health, adopt standard precautions and biosecurity measures in the environment work.

  17. Patient involvement in research priorities (PIRE)

    DEFF Research Database (Denmark)

    Piil, Karin; Jarden, Mary

    2016-01-01

    Introduction: Patient involvement in healthcare has expanded from the clinical practice setting to include collaboration during the research process. There has been a growing international interest in patient and public involvement in setting research priorities to reduce the risk of discrepancy...... between what patients with cancer and their relatives experience as important unanswered questions and those which are actually researched. This study aims to challenge the conventional research process by inviting patients with life-threatening cancer (primary malignant brain tumours or acute leukaemia......), relatives and patient organisations to join forces with clinical specialists and researchers to identify, discuss and prioritise supportive care and rehabilitation issues in future research. Methods and analysis: This is an exploratory qualitative study comprising two sets of three focus group interviews...

  18. Central nervous system involvement by multiple myeloma

    DEFF Research Database (Denmark)

    Jurczyszyn, Artur; Grzasko, Norbert; Gozzetti, Alessandro

    2016-01-01

    The multicenter retrospective study conducted in 38 centers from 20 countries including 172 adult patients with CNS MM aimed to describe the clinical and pathological characteristics and outcomes of patients with multiple myeloma (MM) involving the central nervous system (CNS). Univariate......, 97% patients received initial therapy for CNS disease, of which 76% received systemic therapy, 36% radiotherapy and 32% intrathecal therapy. After a median follow-up of 3.5 years, the median overall survival (OS) from the onset of CNS involvement for the entire group was 7 months. Untreated...... untreated patients and patients with favorable cytogenetic profile might be prolonged due to systemic treatment and/or radiotherapy. This article is protected by copyright. All rights reserved....

  19. Cranial nerve involvement in nasopharyngeal carcinoma

    International Nuclear Information System (INIS)

    Oezyar, E.; Atahan, I.L.; Akyol, F.H.; Guerkaynak, M.; Zorlu, A.F.

    1994-01-01

    Between 1975 and 1989, 23 nasopharyngeal carcinoma patients presenting with cranial nerve involvement (CNI) of one or more nerves at the time of diagnosis were treated and followed-up in our department. All patients were irradiated with curative intent, and total doses of 50 to 70 Gy (median 65 Gy) were delivered to the nasopharynx. Cranial nerves VI, III, V, IV, IX, and XII were the most commonly involved nerves. The total response rate of cranial nerves was 74% in a median follow-up time of 2 years, with the highest rate observed in the third and sixth cranial nerves. All complete responses except two were observed in the first month after radiotherapy. (author)

  20. Bladder Involvement in Stage I Endometriosis.

    Science.gov (United States)

    Brady, Paula C; Missmer, Stacey A; Laufer, Marc R

    2017-08-01

    Endometriosis-the ectopic implantation of endometrial-like tissue-affects 10% of adolescent females and adults. Bladder involvement, causing dysuria and hematuria, occurs in a very small number of endometriosis patients. The patient presented at age 12 years with dysuria and pelvic pain. Laparoscopy revealed stage I endometriosis. Postoperatively, she reported persistent dysuria and passage of tissue in her urine. Cystoscopy showed diffuse erythema; urine cytology revealed glandular and spindle cells suggestive of endometriosis. She was transitioned from oral contraceptives to an intranasal gonadotropin-releasing hormone agonist, with symptom resolution. Intravesicular endometriosis coinciding with stage I disease supports a mechanism of endometriosis dissemination other than direct bladder infiltration. Patients with endometriosis who complain of urinary symptoms warrant assessment, because intravesicular bladder involvement cannot be excluded using pelviscopy. Copyright © 2017 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.

  1. Challenges with social media for user involvement

    OpenAIRE

    Ståhlbröst, Anna

    2012-01-01

    Integrating social media into the innovation process can offer great opportunities for organizations striving for user involvement. Due to the spread of social media in all types of user groups it is, today, possible to engage users all around the world in innovation activities simultaneously. But even if social media usage in innovation activities offers great opportunities, it can be challenging to know how to use it to engage users in these processes. In this paper, the purpose is to discu...

  2. [The impact of socially involved films].

    Science.gov (United States)

    Mimoun, M

    1979-01-01

    During the past few years studies on linguistics and particularly on semiology have considerably renewed the approach and investigation methods in artistic expression. Ideology has several languages and expression systems (photography, painting, music, speech, architecture and so on). The film does not only carry an ideological content: besides the signification systems and the signs taken from other means of films. To consider only films which have the ostensible objective to urge the public to a political action as socially involved is wrong: any movie is socially involved. One must appreciate correctly and politically the place, role and level at which it intervenes in the framework of the ideological fight. Audiovisual alphabetization is essential for the progress of new ideas in the field of picture and sound. In the Third World, when they do exist, cinematographies rarely have the political power to consider such an action. Ideological impact depends mostly on the social, political and cultural environment. A movie is 1st questioned from the standpoint of the historical place and of the problems of the public. The example of Algerian cinematography as a socially involved one is given. At its origin, film-making in this country was working at informing the outside world of the meaning of the people's fight. Its goal was to capture the political and social reality in order to change it. Therefore the social involvement role of Algerian film-producing is tightly connected to the revolutionary process in which the whole country is engaged. Algerian film-producing is often understood as a propaganda cinematography. The stagnation or progress of a cinematography cannot be measured in relation to the universal mythical culture, but in relation to the social and cultural reality of the country where it originates. The present deepening of the reflection on film and ideology is a result of a recent accentuation of the ideologic fight.

  3. Measuring customer involvement in new service developments

    OpenAIRE

    Larbig-Wust, Christine

    2010-01-01

    Service marketing managers are being required to develop new services that succeed in the market and are valuable for customers. Services Marketing literature therefore stresses the need to innovate with customers and to integrate their view into the new service developed. However, consensus about the positive effects of customer involvement in new service development (NSD) has not been reached. Drawing on the theory of organisational knowledge creation and the concept of marketing orientatio...

  4. Radiologically- detectable sacroiliac involvement in behcet's disease

    International Nuclear Information System (INIS)

    Nadji, A.; Shabani, M.; Jamshidi, A.; Shahram, F.; Davatchi, F.

    2003-01-01

    Background: The association of Behcet's disease and ankylosing spondylitis is still a matter of debate. Objective: As the presence of sacroiliac joint involvement is an essential criterion in diagnosis of ankylosing spondylitis . We decided to determined the prevalence of sacroiliac joint involvement in Behcet's disease and compare it with that of a control group. Patients and Methods: We randomly selected two groups of 199 Behcet's disease patients and 168 non- Behcet's disease cases (the controls). All cases were over 20 years of ages. Standard anteroposterior radiographs of the sacroiliac joint were obtained and interpreted by two rheumatologists and a radiologists blinded to the diagnosis. To determined the severity of the condition, the following 5-point scale was employed: Normal (O), pseudo-widening (1), sclerosis (2), erosion (3), and bony fusion (4). The eliminate any doubt, only grades 3 and 4 were considered as sacroiliitis. Both group were separately evaluated for age (≤ 30, and ≥ 30), and gender. Results were compared using Chi square test. Results: The groups were matched for age and sex: There were 98 (49.2%) females in Behcet's disease vs. 91 (54.2%) in the control group (p=O.35). The mean ±SD age was 35±8.3 years in Behcet's disease and 35 ±10 in control group (p=1). The sacroiliac joint was involved in 9 (4.6%) patients in Behcet's disease and 7 (4.2%) patients in control group (p=O.93). Comparisons between the results of the unisexual cohorts revealed to significance either (p=O.68 for males, and p=O.64 for females). The age subdivisions (under- and over-30) again showed no significant difference (p=O.96 and p=O.69 for under- and over -30 patients, respectively). Conclusion: The presence of radiographic signs of sacroiliac joint involvement is not mandatory for the diagnosis of ankylosing spondylitis

  5. Justification: How to get referring physicians involved

    International Nuclear Information System (INIS)

    Remedios, D.

    2011-01-01

    Barriers to involvement of clinicians in the process of justification include an already overloaded knowledge base, lack of time, inconsistent guidance and disproportionate patient expectations. Strategies to improve referring physicians' input include education, use of imaging referral guidelines, clinical audit and regulation. This article discusses and reviews evidence for approaches to encourage greater participation in justification by clinicians. Approaches are best summarised by 'Awareness, appropriateness and audit'. (authors)

  6. Recent Experiments Involving Few-Nucleon Systems

    Science.gov (United States)

    Tornow, W.

    2014-08-01

    Recent experimental results are presented for reactions involving A = 3 to A = 6 nuclear systems. The emphasis is on unique data obtained at new experimental facilities. It is shown that the inertial confinement fusion facilities OMEGA and NIF provide a largely unexpected opportunity for experimental few-body physics to both obtain data of unprecedented quality and extend previous measurements to energies not accessible in the past. Whenever possible, data are compared to state-of-the-art theoretical calculations.

  7. Determinants of Parent Involvement in Romanian Schools

    OpenAIRE

    Diana Damean

    2010-01-01

    The paper is focused on exploring the factors that facilitate parent involvement in their child’s education and school life. A sample of 670 Romanian school principals from the Cross-National Survey of School Principals in South East Europe (SEE) countries 2008 was used. Two-step linear regressions were run in order to predict parent participation in school meetings, parent engagement in school activities and parent influence in school governance, as reported by school principals. The results...

  8. Electrical Breakdown Phenomena Involving Material Interfaces

    Science.gov (United States)

    2013-06-01

    create ozone through chemical reactions involving reactive species created by the electrical discharge [3]. The glow discharge breakdown in such...2. REPORT TYPE N/A 3. DATES COVERED - 4. TITLE AND SUBTITLE Investigation Of Pre-Ionization And Atmospheric Pulsed Discharge Plasma 5a...growth of the air discharge in the form of a conductive filament consisting of electrons and ions. This filament is created by temporal pulse that

  9. Family involvement and helping behaviour in teams

    OpenAIRE

    Brummelhuis, L.L. ten; Lippe, T. van der; Kluwer, E.S.

    2010-01-01

    Helping behavior at work has become increasingly important, with organizations making more and more use of cooperative work practices. The difficulty is that employees are facing growing demands beyond the workplace. This study investigates the mechanisms by which family involvement (family structure, family tasks, family support) affects helping behavior in teams. Based on a sample of 495 team members, the results show that having a supportive partner and performing care tasks increase helpi...

  10. Roentgenological semiotics of joint involvement in psoriasis

    International Nuclear Information System (INIS)

    Spuzyak, M.I.

    1986-01-01

    The paper is concerned with the results of an X-ray study of the osteoarticular system of 103 patients with arthropathic psoriasis. Four types of disease: psoriatic polyarthritis, psoriatic polyarthrosis, psoriatic arthropathy and a mixed or combined form (the combination of inflammatory and degenerative-dystrophic changes) - were defined on the basis of X-ray findings. Roentgenological semiotics of these forms of arthropathic psoriasis with the frequency of the involvement of some joints and elements of differential radiodiagnosis was proposed

  11. Children Involvement on Family Purchase Decision Making

    OpenAIRE

    Jostein, Revina Wintry

    2013-01-01

    Children take big involvement in family decision making process today. There are several factors that make this phenomenon happen, such as media influence. Currently, the development of information and communication technology is so fast, indirectly encourages all parties, including the children to be able to follow the changes. There are two main objectives that will be examined, related with all the stated problems at the previous section, which are to analyze which product category does ch...

  12. Multiple Cranial Nerve Involvement In Cryptococcal Meningitis

    OpenAIRE

    Mahadevan A; Kumar A; Santosh V; Satishchandra P; Shankar S.K

    2000-01-01

    Cryptococcal meningitis is an uncommon cause of multiple cranial nerve palsies. This case report illustrates one such case of cryptococcal meningitis clinically manifesting with extensive cranial nerve involvement in an HIV seronegative individual. Histology revealed infiltration of the cranial nerves by cryptococci causing axonal disruption with secondary demyelination in the absence of any evidence of inflammation or vasculitis. We believe that axonal damage underlies the pathogenesis of...

  13. Recent Experiments Involving Few-Nucleon Systems

    International Nuclear Information System (INIS)

    Tornow, W.

    2014-01-01

    Recent experimental results are presented for reactions involving A = 3 to A = 6 nuclear systems. The emphasis is on unique data obtained at new experimental facilities. It is shown that the inertial confinement fusion facilities OMEGA and NIF provide a largely unexpected opportunity for experimental few-body physics to both obtain data of unprecedented quality and extend previous measurements to energies not accessible in the past. Whenever possible, data are compared to state-of-the-art theoretical calculations. (author)

  14. Promoting principals' managerial involvement in instructional improvement.

    Science.gov (United States)

    Gillat, A

    1994-01-01

    Studies of school leadership suggest that visiting classrooms, emphasizing achievement and training, and supporting teachers are important indicators of the effectiveness of school principals. The utility of a behavior-analytic program to support the enhancement of these behaviors in 2 school principals and the impact of their involvement upon teachers' and students' performances in three classes were examined in two experiments, one at an elementary school and another at a secondary school. Treatment conditions consisted of helping the principal or teacher to schedule his or her time and to use goal setting, feedback, and praise. A withdrawal design (Experiment 1) and a multiple baseline across classrooms (Experiment 2) showed that the principal's and teacher's rates of praise, feedback, and goal setting increased during the intervention, and were associated with improvements in the academic performance of the students. In the future, school psychologists might analyze the impact of involving themselves in supporting the principal's involvement in improving students' and teachers' performances or in playing a similar leadership role themselves.

  15. Lung involvement in systemic connective tissue diseases

    Directory of Open Access Journals (Sweden)

    Plavec Goran

    2008-01-01

    Full Text Available Background/Aim. Systemic connective tissue diseases (SCTD are chronic inflammatory autoimmune disorders of unknown cause that can involve different organs and systems. Their course and prognosis are different. All of them can, more or less, involve the respiratory system. The aim of this study was to find out the frequency of respiratory symptoms, lung function disorders, radiography and high-resolution computerized tomography (HRCT abnormalities, and their correlation with the duration of the disease and the applied treatment. Methods. In 47 non-randomized consecutive patients standard chest radiography, HRCT, and lung function tests were done. Results. Hypoxemia was present in nine of the patients with respiratory symptoms (20%. In all of them chest radiography was normal. In five of these patients lung fibrosis was established using HRCT. Half of all the patients with SCTD had symptoms of lung involvement. Lung function tests disorders of various degrees were found in 40% of the patients. The outcome and the degree of lung function disorders were neither in correlation with the duration of SCTD nor with therapy used (p > 0.05 Spearmans Ro. Conclusion. Pulmonary fibrosis occurs in about 10% of the patients with SCTD, and possibly not due to the applied treatment regimens. Hypoxemia could be a sing of existing pulmonary fibrosis in the absence of disorders on standard chest radiography.

  16. Interstitial lung involvement in rheumatoid arthritis

    Directory of Open Access Journals (Sweden)

    David Vladimirovich Bestaev

    2014-01-01

    Full Text Available Rheumatoid arthritis (RA is a systemic autoimmune rheumatic disease of unknown etiology, characterized by chronic erosive arthritis and extraarticular manifestations. Pulmonary involvement is one of the common extraarticular manifestations of RA and may show itself as bronchial tree lesions, rheumatoid nodules, Caplan's syndrome, and lesions in the pleura or pulmonary interstitium (interstitial lung involvement (ILI. High-resolution computed tomography allows the diagnosis of ILI in RA in nearly 70% of cases although the incidence of ILI may be lower (4 to 30% depending on diagnostic methods and patient selection criteria. There are several histopathological types of ILI, the differential diagnosis of which can be troublesome. Usual interstitial pneumonia (UIP and nonspecific interstitial pneumonia are major types of RA-associated ILI. UIP-pattern ILI has a more severe course than ILI with other histological patterns. The clinical presentation of ILI may be complicated by the likely toxic effect of a number of disease-modifying antirheumatic drugs (DMARDs used to treat RA, such as methotrexate and leflunomide, and biological agents (BAs, tumor necrosis factor-α (TNF-α inhibitors. The pathogenesis of pulmonary involvement in RA and the role of synthetic DMARDs and BAs in the development of ILI call for further investigations.An extraarticular manifestation, such as ILI, affects the choice of treatment policy in patients with RA.The relevance of a study of ILI is beyond question. The paper discusses the state-of-the-art of investigations in this area.

  17. Kinases Involved in Both Autophagy and Mitosis.

    Science.gov (United States)

    Li, Zhiyuan; Zhang, Xin

    2017-08-31

    Both mitosis and autophagy are highly regulated dynamic cellular processes and involve various phosphorylation events catalysed by kinases, which play vital roles in almost all physiological and pathological conditions. Mitosis is a key event during the cell cycle, in which the cell divides into two daughter cells. Autophagy is a process in which the cell digests its own cellular contents. Although autophagy regulation has mainly been studied in asynchronous cells, increasing evidence indicates that autophagy is in fact tightly regulated in mitosis. Here in this review, we will discuss kinases that were originally identified to be involved in only one of either mitosis or autophagy, but were later found to participate in both processes, such as CDKs (cyclin-dependent kinases), Aurora kinases, PLK-1 (polo-like kinase 1), BUB1 (budding uninhibited by benzimidazoles 1), MAPKs (mitogen-activated protein kinases), mTORC1 (mechanistic target of rapamycin complex 1), AMPK (AMP-activated protein kinase), PI3K (phosphoinositide-3 kinase) and protein kinase B (AKT). By focusing on kinases involved in both autophagy and mitosis, we will get a more comprehensive understanding about the reciprocal regulation between the two key cellular events, which will also shed light on their related therapeutic investigations.

  18. Genetic Variations Involved in Vitamin E Status

    Directory of Open Access Journals (Sweden)

    Patrick Borel

    2016-12-01

    Full Text Available Vitamin E (VE is the generic term for four tocopherols and four tocotrienols that exhibit the biological activity of α-tocopherol. VE status, which is usually estimated by measuring fasting blood VE concentration, is affected by numerous factors, such as dietary VE intake, VE absorption efficiency, and VE catabolism. Several of these factors are in turn modulated by genetic variations in genes encoding proteins involved in these factors. To identify these genetic variations, two strategies have been used: genome-wide association studies and candidate gene association studies. Each of these strategies has its advantages and its drawbacks, nevertheless they have allowed us to identify a list of single nucleotide polymorphisms associated with fasting blood VE concentration and α-tocopherol bioavailability. However, much work remains to be done to identify, and to replicate in different populations, all the single nucleotide polymorphisms involved, to assess the possible involvement of other kind of genetic variations, e.g., copy number variants and epigenetic modifications, in order to establish a reliable list of genetic variations that will allow us to predict the VE status of an individual by knowing their genotype in these genetic variations. Yet, the potential usefulness of this area of research is exciting with regard to personalized nutrition and for future clinical trials dedicated to assessing the biological effects of the various isoforms of VE.

  19. Breast cancer with axillary lymph node involvement

    International Nuclear Information System (INIS)

    Belaid, A.; Kanoun, S.; Kallel, A.; Ghorbel, I.; Azoury, F.; Heymann, S.; Marsiglia, H.; Bourgier, C.; Belaid, A.; Ghorbel, I.; Kanoun, S.; Kallel, A.; Pichenot, C.; Verstraet, R.; Marsiglia, H.

    2010-01-01

    Breast cancer is the most frequent cancer of women in western countries. There are one million new cases per year in the world which represents 22% of all female cancers, and more than 370.000 deaths due to breast cancer per year (14% of cancer mortality). More than half of breast cancers are associated with axillary nodal involvement. Post-operative radiation therapy (XRT) is a crucial part of locoregional treatment in axillary nodal involvement breast cancer owing to a 15-years risk reduction of locoregional recurrence of 70% and to a 5.4% risk reduction of specific mortality. In 3D-conformal irradiation in such breast cancers, target volumes are chest wall when mastectomy was performed or breast and boost of tumor bed in case of breast conservative surgery, and supra-clavicular and/or axillary and/or internal mammary node areas. The main organs at risk are ipsilateral lung, heart and brachial plexus. The aim of this article is to describe epidemiologic, radio anatomic and prognostic features of axillary nodal involvement breast cancer and to propose guidelines for 3D-conformal treatment planning in locally advanced breast cancers. This review is illustrated by a case report. (authors)

  20. Kinases Involved in Both Autophagy and Mitosis

    Directory of Open Access Journals (Sweden)

    Zhiyuan Li

    2017-08-01

    Full Text Available Both mitosis and autophagy are highly regulated dynamic cellular processes and involve various phosphorylation events catalysed by kinases, which play vital roles in almost all physiological and pathological conditions. Mitosis is a key event during the cell cycle, in which the cell divides into two daughter cells. Autophagy is a process in which the cell digests its own cellular contents. Although autophagy regulation has mainly been studied in asynchronous cells, increasing evidence indicates that autophagy is in fact tightly regulated in mitosis. Here in this review, we will discuss kinases that were originally identified to be involved in only one of either mitosis or autophagy, but were later found to participate in both processes, such as CDKs (cyclin-dependent kinases, Aurora kinases, PLK-1 (polo-like kinase 1, BUB1 (budding uninhibited by benzimidazoles 1, MAPKs (mitogen-activated protein kinases, mTORC1 (mechanistic target of rapamycin complex 1, AMPK (AMP-activated protein kinase, PI3K (phosphoinositide-3 kinase and protein kinase B (AKT. By focusing on kinases involved in both autophagy and mitosis, we will get a more comprehensive understanding about the reciprocal regulation between the two key cellular events, which will also shed light on their related therapeutic investigations.

  1. Resident involvement in civilian tactical emergency medicine.

    Science.gov (United States)

    Ramirez, Mario Luis; Slovis, Corey M

    2010-07-01

    Tactical emergency medicine services (TEMS) has emerged as a specialized niche within the field of emergency medicine. With increasing demand for physician participation in civilian tactical teams, there will be efforts by residents to become involved at earlier points in their clinical training. This article discusses resident involvement with a civilian TEMS unit and provides five maxims for emergency physicians to better understand the difference between working in the emergency department or with emergency medical services vs. in a TEMS environment. Differences between TEMS and other trauma life support models, institutional and political barriers likely to be encountered by the resident, the value of preventive medicine and the role of the physician in long-term tactical operations, opportunities for subspecialty growth, and the role of operational security are all discussed in detail. Tactical emergency medicine is a specialty that utilizes the full array of the emergency physician's skill set. It is also a field that is ripe for continued expansion, but the resident looking to become involved with a team should be aware of the requirements necessary to do so and the obstacles likely to be encountered along the way. Copyright 2010 Elsevier Inc. All rights reserved.

  2. Public involvement in danish energy policy

    International Nuclear Information System (INIS)

    Refslund Poulsen, N.; Breinholt Larsen, F.

    1977-01-01

    A preliminary investigation on ''Public involvment in the Danish energy policy. The nuclear power issue'' was carried out as part of the project on ''Public involvment in decision-making related to science and technology'' performed by the Directorate for Science, Technology and Industry of the OECD in Paris. The historical development of Danish energy policy is briefly described. An account is given of the nuclear controversy, and the development of public opinion is outlined. The public debate has been very widespread and intense, by far the most comprehensive debate since that concerning the European Communities. Assuming that the development of public opinion reflects the relative success or failure of the contending parties, the opponents of nuclear energy seem to have done best. Opinion polls showed some marked deviations among the electorate according to different variables. The most striking were those observed in relation to sex, age, education, and political preferences. One chapter treats the attitude of public authorities to extended public involvment, and special accounts are given of the Energy Information Committee, and the Energy Council. Finally the prime movers of the nuclear debate are dealt with, in particular the Organization for Information on Nuclear Energy OOA, which opposes nuclear power. (B.P.)

  3. Adolescents' Psychological Well-Being and Perceived Parental Involvement: Implications for Parental Involvement in Middle Schools

    Science.gov (United States)

    Cripps, Kayla; Zyromski, Brett

    2009-01-01

    Adolescence is a critical period of development. Previous research suggests parent involvement in school directly impacts student success. However, different types of parental involvement and the efforts of middle school personnel to educate parents about these effective practices have received scant attention in the literature. The level and type…

  4. Bladder involvement in systemic lupus erythematosus

    Directory of Open Access Journals (Sweden)

    Eric Roger Wroclawski

    2009-12-01

    Full Text Available Objective: To study bladder involvement in systemic lupus erythematosus patients through clinical and laboratorial evaluation, ultrasonography, radiological and endoscopic examination. Methods: Thirty-nine patients, either outpatients or inpatients at the Department of Rheumatology of Hospital das Clínicas da Faculdade de Medicina from Universidade de São Paulo were evaluated as to clinical and laboratorial data. All patients were submitted to ultrasonographic evaluation of the upper urinary tract, radiological and endoscopic examinations of the middle and lower urinary tracts. Rresults: Mean age of patients varied between 13 and 62 years (median = 29 years. Thirty-six were females and three were males. The disease varied from 6 months to 22 years (median three years and one month. Clinical and laboratory activity of the disease was present in 30 patients. Twenty-two patients had the diagnosis of lupus established for three years or more. Twenty-five patients were asymptomatic and all had received corticosteroids for treatment at least once. Twenty-three received antimalarial drugs; ten received cytostatics, and seven patients received non-steroid anti-inflammatory drugs. Upper urinary tract ultrasonography was normal in all cases but one with staghorn calculus associated with neurogenic bladder secondary to neurological involvement by the disease. Vesicoureteral reflux was observed in two cases. Other two patients had significant post-voiding residual urine, both with neurogenic bladder secondary to nervous system involvement by lupus. The average bladder maximum capacity in an awaken patient was 342 mL, and was decreased in 18.9% of cases. This subgroup of patients presented a greater frequency of urinary symptoms and greater use of cytostatic drugs (Z > Z5%. A pathognomonic cystoscopic pattern of bladder involvement in systemic lupus erythematosus could not be established. Cystoscopic aspects similar to those seen in the initial or minor

  5. Scientists Involved in K-12 Education

    Science.gov (United States)

    Robigou, V.

    2004-12-01

    The publication of countless reports documenting the dismal state of science education in the 1980s, and the Third International Mathematics and Science Study (TIMMS) report (1996) called for a wider involvement of the scientific community in K-12 education and outreach. Improving science education will not happen without the collaboration of educators and scientists working in a coordinated manner and it requires a long-term, continuous effort. To contribute effectively to K-12 education all scientists should refer to the National Science Education Standards, a set of policies that guide the development of curriculum and assessment. Ocean scientists can also specifically refer to the COSEE recommendations (www.cosee.org) that led to the creation of seven regional Centers for Ocean Sciences Education Excellence. Scientists can get involved in K-12 education in a multitude of ways. They should select projects that will accommodate time away from their research and teaching obligations, their talent, and their interest but also contribute to the education reform. A few examples of effective involvement are: 1) collaborating with colleagues in a school of education that can lead to better education of all students and future teachers, 2) acting as a resource for a national program or a local science fair, 3) serving on the advisory board of a program that develops educational material, 4) speaking out at professional meetings about the value of scientists' involvement in education, 5) speaking enthusiastically about the teaching profession. Improving science education in addition to research can seem a large, overwhelming task for scientists. As a result, focusing on projects that will fit the scientist's needs as well as benefit the science reform is of prime importance. It takes an enormous amount of work and financial and personnel resources to start a new program with measurable impact on students. So, finding the right opportunity is a priority, and stepping

  6. Contrast enhanced ultrasound of splenic lymphoma involvement

    International Nuclear Information System (INIS)

    Goerg, Christian; Faoro, Charis; Bert, Tillmann; Tebbe, Johannes; Neesse, Albrecht; Wilhelm, Christian

    2011-01-01

    Objective: The aim of this study was to compare the value of contrast-enhanced ultrasonography (CEUS) with standard B-mode ultrasound (US) for diagnosis of splenic lymphoma involvement. Methods: From 04/2005 to 10/2008 n = 250 lymphoma patients were investigated by standard B-mode US. A homogeneous splenic echotexture was found in 199 patients (79%). To clarify the benefit of CEUS in this group a pilot series was performed with 16 of the 199 lymphoma patients. All patients with an abnormal splenic echotexture on standard B-Mode US (n = 51) including focal hypoechoic splenic lesions (n = 41) and an inhomogeneous splenic texture (n = 10) were studied by CEUS. CEUS data were retrospectively evaluated. The diagnoses included indolent lymphoma (n = 27), aggressive lymphoma (n = 14), and Hodgkin's disease (n = 10). Number and size of lesions were determined by B-mode US and CEUS. The visualisation of splenic lymphoma involvement by CEUS in comparison to B-mode US was classified as worse, equal, or better. Results: All patients with a homogeneous spleen on B-mode US (n = 16) had no visible focal lesions on CEUS. Study patients with focal lesions (n = 41) had a hypoechoic (n = 22) or isoechoic (n = 19) enhancement during the arterial phase, and a hypoechoic enhancement during the parenchymal phase (n = 41). The visualisation of focal splenic lymphoma was equal (n = 32), better (n = 6), or worse (n = 3). In all study patients with an inhomogeneous spleen on B-mode US (n = 10) no focal lesions were found by CEUS and the value of CEUS therefore was classified as worse. Conclusion: CEUS has no clear advantage for diagnosis of splenic lymphoma involvement.

  7. Contrast enhanced ultrasound of splenic lymphoma involvement

    Energy Technology Data Exchange (ETDEWEB)

    Goerg, Christian, E-mail: goergc@med.uni-marburg.de [Medizinische Universitaetsklinik, Baldingerstrasse, 35033 Marburg/Lahn (Germany); Faoro, Charis [Medizinische Universitaetsklinik, Baldingerstrasse, 35033 Marburg/Lahn (Germany); Bert, Tillmann [Zentralklinik Bad Berka GmbH, Robert-Koch-Allee 9, 99437 Bad Berka (Germany); Tebbe, Johannes [Klinikum Lippe-Detmold, Roentgenstrasse 18, 32756 Detmold (Germany); Neesse, Albrecht; Wilhelm, Christian [Medizinische Universitaetsklinik, Baldingerstrasse, 35033 Marburg/Lahn (Germany)

    2011-11-15

    Objective: The aim of this study was to compare the value of contrast-enhanced ultrasonography (CEUS) with standard B-mode ultrasound (US) for diagnosis of splenic lymphoma involvement. Methods: From 04/2005 to 10/2008 n = 250 lymphoma patients were investigated by standard B-mode US. A homogeneous splenic echotexture was found in 199 patients (79%). To clarify the benefit of CEUS in this group a pilot series was performed with 16 of the 199 lymphoma patients. All patients with an abnormal splenic echotexture on standard B-Mode US (n = 51) including focal hypoechoic splenic lesions (n = 41) and an inhomogeneous splenic texture (n = 10) were studied by CEUS. CEUS data were retrospectively evaluated. The diagnoses included indolent lymphoma (n = 27), aggressive lymphoma (n = 14), and Hodgkin's disease (n = 10). Number and size of lesions were determined by B-mode US and CEUS. The visualisation of splenic lymphoma involvement by CEUS in comparison to B-mode US was classified as worse, equal, or better. Results: All patients with a homogeneous spleen on B-mode US (n = 16) had no visible focal lesions on CEUS. Study patients with focal lesions (n = 41) had a hypoechoic (n = 22) or isoechoic (n = 19) enhancement during the arterial phase, and a hypoechoic enhancement during the parenchymal phase (n = 41). The visualisation of focal splenic lymphoma was equal (n = 32), better (n = 6), or worse (n = 3). In all study patients with an inhomogeneous spleen on B-mode US (n = 10) no focal lesions were found by CEUS and the value of CEUS therefore was classified as worse. Conclusion: CEUS has no clear advantage for diagnosis of splenic lymphoma involvement.

  8. Spent fuel transportation accident: a state's involvement

    International Nuclear Information System (INIS)

    Neuweg, M.

    1978-01-01

    On February 9, 1978 at 8:20 p.m., the duty officer for the Illinois Radiological Assistance Team was notified that a shipment containing uranium and plutonium was involved in an accident near Gibson City, Illinois on Route 54. It was reported that a pig containing an unknown amount of uranium and plutonium was involved. The Illinois District 6A State Police were called to the scene and secured the area. The duty officer in the meantime learned after numerous telephone calls, approximately 1 hour after the first notice was received, that the pig actually was a 48,000 pound cask containing 6 spent fuel rods and the tractor-trailer had split apart and was blocking one lane of the highway. The shipment had departed from Dresden Nuclear Power Station, Morris, Illinois, enroute to Babcox and Wilcox in Lynchburg, Virginia. Initial reports indicated the vehicle had split apart. Actually, the semi-trailer bed had buckled beneath the cask due to apparent excess stress. The cask remained entirely intact and was not damaged, but the state highway was closed to traffic. The State Radiological Assistance Team was dispatched and arrived on the scene at 12:45 a.m. Immediate radiation monitoring revealed a reading of 4 milliroentgen per hour at 10 feet from the cask. No contamination existed nor was anyone exposed to radiation unnecessarily. The cask was transferred to a Tri-State semi-trailer vehicle the following morning at approximately 6:30 a.m. At 9:30 a.m., February 10, the new vehicle was again enroute to its destination. This incident demonstrated typical occurrences involving transportation radiation accident: misinformation and/or lack of information on the initial response notification, inaccuracies of radiation monitorings at the scene of the accident, inconsistencies concerning the occurrences of the accident and unfamiliar terminology utilized by personnel first on the scene, i.e., pig, cask, vehicle split apart, etc

  9. Optimisation: how to develop stake holder involvement

    International Nuclear Information System (INIS)

    Weiss, W.

    2003-01-01

    The Precautionary Principle is an internationally recognised approach for dealing with risk situations characterised by uncertainties and potential irreversible damages. Since the late fifties, ICRP has adopted this prudent attitude because of the lack of scientific evidence concerning the existence of a threshold at low doses for stochastic effects. The 'linear, no-threshold' model and the 'optimisation of protection' principle have been developed as a pragmatic response for the management of the risk. The progress in epidemiology and radiobiology over the last decades have affirmed the initial assumption and the optimisation remains the appropriate response for the application of the precautionary principle in the context of radiological protection. The basic objective of optimisation is, for any source within the system of radiological protection, to maintain the level of exposure as low as reasonably achievable, taking into account social and economical factors. Methods tools and procedures have been developed over the last two decades to put into practice the optimisation principle with a central role given to the cost-benefit analysis as a means to determine the optimised level of protection. However, with the advancement in the implementation of the principle more emphasis was progressively given to good practice, as well as on the importance of controlling individual levels of exposure through the optimisation process. In the context of the revision of its present recommendations, the Commission is reenforcing the emphasis on protection of the individual with the adoption of an equity-based system that recognizes individual rights and a basic level of health protection. Another advancement is the role that is now recognised to 'stakeholders involvement' in the optimisation process as a mean to improve the quality of the decision aiding process for identifying and selecting protection actions considered as being accepted by all those involved. The paper

  10. Involvement of serotonin system in bullimia

    International Nuclear Information System (INIS)

    Marazziti, D.; Macchi, E.; Rotondo, A.; Placidi, G.F.; Cassano, G.B.

    1988-01-01

    Platelet 3 H-imipramine binding was investigated in 8 patients affected by bulimia according to DSM III criteria, and in 7 health volunteers. The Bmax /+ -/SD (fmol/mg protein) was 356 /+ -/ 53 in patients, and 1144 /+ -/ 134 in controls. The Kd /+ -/ SD (nM) was 1.35 /+ -/ 0.44 in patients, and 1.90 /+ -/ 0.72 in controls. There was a significant difference in Bmax values in the two groups, whereas no significant difference was observed in Kd values. This study suggests the possible involvement of the indoleamine system in bullimia

  11. Stakeholder involvement in decommissioning nuclear facilities

    International Nuclear Information System (INIS)

    2007-01-01

    Significant numbers of nuclear facilities will need to be decommissioned in the coming decades. In this context, NEA member countries are placing increasing emphasis on the involvement of stakeholders in the associated decision procedures. This study reviews decommissioning experience with a view to identifying stakeholder concerns and best practice in addressing them. The lessons learnt about the end of the facility life cycle can also contribute to better foresight in siting and building new facilities. This report will be of interest to all major players in the field of decommissioning, in particular policy makers, implementers, regulators and representatives of local host communities

  12. Stakeholder involvement in CSR strategy-making?

    DEFF Research Database (Denmark)

    Trapp, Leila

    2014-01-01

    A given characteristic of successful corporate social responsibility (CSR) programs is that they reflect stakeholder expectations and preferences for corporate behavior. This study examines the process by which this alignment is sought by CSR managers in the CSR strategy-making process. Through...... listening to others in the strategy-making process rather than directly involving others in decision-making. Also, because non-stakeholders, such as paid-for consultants, are found to be note-worthy influencers in the CSR strategy-making process, it is concluded that the process is not only a stakeholder...

  13. Involvement of serotonin system in bullimia

    Energy Technology Data Exchange (ETDEWEB)

    Marazziti, D.; Macchi, E.; Rotondo, A.; Placidi, G.F.; Cassano, G.B.

    1988-01-01

    Platelet /sup 3/H-imipramine binding was investigated in 8 patients affected by bulimia according to DSM III criteria, and in 7 health volunteers. The Bmax /+ -/SD (fmol/mg protein) was 356 /+ -/ 53 in patients, and 1144 /+ -/ 134 in controls. The Kd /+ -/ SD (nM) was 1.35 /+ -/ 0.44 in patients, and 1.90 /+ -/ 0.72 in controls. There was a significant difference in Bmax values in the two groups, whereas no significant difference was observed in Kd values. This study suggests the possible involvement of the indoleamine system in bullimia.

  14. Charge exchange processes involving iron ions

    International Nuclear Information System (INIS)

    Phaneuf, R.A.

    1985-01-01

    A review and evaluation is given of the experimental data which are available for charge exchange processes involving iron ions and neutral H, H 2 and He. Appropriate scaling laws are presented, and their accuracy estimated for these systems. A bibliography is given of available data sources, as well as of useful data compilations and review articles. A procedure is recommended for providing single approximate formulae to the fusion community to describe total cross sections for electron capture by partially-stripped Fe/sup q+/ ions in collisions with H, H 2 and He, based on the scaling relationships suggested by Janev and Hvelplund

  15. Nonleptonic B decays involving tensor mesons

    Energy Technology Data Exchange (ETDEWEB)

    Lopez Castro, G. [Departamento de Fisica, Cinvestav del IPN, Apdo. Postal 14-740, 07000 Mexico, D.F. (Mexico); Munoz, J.H. [Departamento de Fisica, Cinvestav del IPN, Apdo. Postal 14-740, 07000 Mexico, D.F. (Mexico)]|[Departamento de Fisica, Universidad del Tolima, A.A. 546, Ibague (Colombia)

    1997-05-01

    Two-body nonleptonic decays of B mesons into PT and VT modes are calculated using the nonrelativistic quark model of Isgur {ital et al.} The predictions obtained for B{r_arrow}{pi}D{sub 2}{sup {asterisk}},{rho}D{sub 2}{sup {asterisk}} are a factor of 3{endash}5 below present experimental upper limits. Interesting patterns are obtained for ratios of B decays involving mesons with different spin excitations and their relevance for additional tests of forms factor models are briefly discussed. {copyright} {ital 1997} {ital The American Physical Society}

  16. Giant Parotid Pleomorphic Adenoma Involving Parapharyngeal Space

    Directory of Open Access Journals (Sweden)

    Sukri Rahman

    2013-09-01

    Full Text Available AbstrakLatar belakang: Pleomorfik adenoma parotis merupakan tumor jinak kelenjar liur yang paling sering ditemukan, namun pleomorfik adenoma parotis yang sangat besar sehingga melibatkan ruang parafaring (RPF sangat jarang. Diagnosis ini sulit ditegakkan karena gejala klinisnya tidak khas. Penatalaksanaanya harus hati-hati mengingat banyak struktur vital yang beresiko mengalami trauma. Tujuan: Bagaimana menegakkan diagnosis dan penatalaksanaan pleomorfik adenoma parotis yang melibatkan RPF. Kasus: Seorang pasien perempuan 27 tahun ditegakkan diagnosis pleomorfik adenoma parotis kanan dengan melibatkan RPF. Terdapat pembengkakan pada leher yang bersifat asimtomatis dan gejala pendorongan faring dan laring yang menyebabkan disfonia, disfagia, dan defisit saraf kranial IX,X,XII. Penatalaksanaan: Pasien telah dilakukan operasi parotidektomi pendekatan transervikal–transparotid dengan preservasi arteri karotis eksterna dan saraf fasialis. Kesimpulan: Biopsi Aspirasi Jarum Halus (BAJAH dan radiologi merupakan pemeriksaan yang penting untuk menegakkan diagnosis. Penatalaksanaan pleomorfik adenoma parotis yang melibatkan RPF adalah bedah ekstirpasi komplit dengan beberapa pendekatan. .Kata kunci: tumor jinak kelenjar liur, pleomorfik adenoma, ruang parafaringAbstractBackground: Parotid pleomorphic adenoma is the most common benign salivary gland tumor, while giant parotid pleomorphic adenoma involving the parapharyngeal space (PPS is rare. It was difficult to diagnose because the clinical presentation of this tumor can be subtle. The management must be performed carefully due to anatomy relation to complex vital structure lead to traumatic injury highrisk. Purposes: How to make diagnosis and management parotid pleomorphic adenoma involving PPS. Case: A female 27 years old with diagnosis was giant parotid pleomorphic adenoma involving PPS. There was asymptomatic swelling of the neck and presence of pushing the pharynx and larynx medially causes

  17. User involvement competence for radical innovation

    DEFF Research Database (Denmark)

    Lettl, Christopher

    2007-01-01

    -assisted navigation systems. The case study analysis reveals that firms who closely interact with specific users benefit significantly for their radical innovation work. These users have a high motivation toward new solutions, are open to new technologies, possess diverse competencies, and are embedded into a very......One important market related capability for firms which seek to develop radical innovations is the competence to involve the 'right' users at the 'right' time in the 'right' form. While former studies have identified a rather passive role of users in the radical innovation process, this paper...

  18. User involvement competence for radical innovation

    DEFF Research Database (Denmark)

    Lettl, Christopher

    2007-01-01

    One important market related capability for firms which seek to develop radical innovations is the competence to involve the 'right' users at the 'right' time in the 'right' form. While former studies have identified a rather passive role of users in the radical innovation process, this paper......-assisted navigation systems. The case study analysis reveals that firms who closely interact with specific users benefit significantly for their radical innovation work. These users have a high motivation toward new solutions, are open to new technologies, possess diverse competencies, and are embedded into a very...

  19. Buried Waste Integrated Demonstration stakeholder involvement model

    International Nuclear Information System (INIS)

    Kaupanger, R.M.; Kostelnik, K.M.; Milam, L.M.

    1994-04-01

    The Buried Waste Integrated Demonstration (BWID) is a program funded by the US Department of Energy (DOE) Office of Technology Development. BWID supports the applied research, development, demonstration, and evaluation of a suite of advanced technologies that together form a comprehensive remediation system for the effective and efficient remediation of buried waste. Stakeholder participation in the DOE Environmental Management decision-making process is critical to remediation efforts. Appropriate mechanisms for communication with the public, private sector, regulators, elected officials, and others are being aggressively pursued by BWID to permit informed participation. This document summarizes public outreach efforts during FY-93 and presents a strategy for expanded stakeholder involvement during FY-94

  20. The mechanisms involved at the cell level

    International Nuclear Information System (INIS)

    Leblanc, G.; Pourcher, Th.; Perron, B.; Guillain, F.; Quemeneur, E.; Fritsch, P.

    2003-01-01

    The mechanisms responsible at the cell level for inducing toxic reactions after contamination are as yet only imperfectly known. Work still needs to be done for both contaminants that have a biological role, such as iodine, and those that do not, such as cadmium, uranium and plutonium. In particular, these mechanisms bring into play, in biological membranes, carriers which are the physiological partners responsible for material exchange with the environment or inside the body. As they lack absolute selectivity, these carriers, which are involved in the assimilation and accumulation of vital mineral elements, also have the ability to transport toxic elements and isotopes. (authors)

  1. Ion Channels Involved in Cell Volume Regulation

    DEFF Research Database (Denmark)

    Hoffmann, Else Kay

    2011-01-01

    regulatory ion channels involved, and the mechanisms (cellular signalling pathways) that regulate these channels. Finally, I shall also briefly review current investigations in these two cell lines that focuses on how changes in cell volume can regulate cell functions such as cell migration, proliferation......This mini review outlines studies of cell volume regulation in two closely related mammalian cell lines: nonadherent Ehrlich ascites tumour cells (EATC) and adherent Ehrlich Lettre ascites (ELA) cells. Focus is on the regulatory volume decrease (RVD) that occurs after cell swelling, the volume...

  2. Renal involvement in primary antiphospholipid syndrome.

    Science.gov (United States)

    Marcantoni, Carmelita; Emmanuele, Carmela; Scolari, Francesco

    2016-08-01

    Antiphospholipid syndrome is an autoimmune disorder characterized by recurrent venous or arterial thrombosis and/or pregnancy-related problems associated with persistently elevated levels of antiphospholipid antibodies. The kidney is a major target organ in both primary and secondary antiphospholipid syndrome. This review describes several aspects of the renal involvement in the primary form of the syndrome, in particular the histological pattern of the so-called antiphospholipid syndrome nephropathy (APSN). APSN is a vascular nephropathy characterized by small vessel vaso-occlusive lesions associated with fibrous intimal hyperplasia of interlobular arteries, recanalizing thrombi in arteries and arterioles, and focal atrophy, a constellation of morphological lesions suggestive of primary antiphospholipid syndrome.

  3. Systemic involvement in localized scleroderma/morphea.

    Science.gov (United States)

    Gorkiewicz-Petkow, Anna; Kalinska-Bienias, Agnieszka

    2015-01-01

    Localized scleroderma (LoSc), also known as morphea, is a rare fibrosing disorder of the skin and underlying tissues. Sclerosis is mainly limited to the skin, but subcutaneous tissue, fascia, and underlying muscles and bone may also be involved. In some cases, systemic manifestation with visceral abnormalities may occur. Several publications have focused on significant aspects of LoSc: genetics, immunity, epidemiology, scoring systems, and unification of classifications. Clinical studies featuring large cohorts with the disease published by various international study groups have been of great value in furthering the diagnostic and therapeutic management of LoSc. Copyright © 2015 Elsevier Inc. All rights reserved.

  4. National Parks and social involvement - an argument

    Directory of Open Access Journals (Sweden)

    J.A. Loader

    1994-08-01

    Full Text Available Discrimination, whether institutionalised or not, is described as the expression of prejudice, which, it is argued, is derived from projectionism, or the supposition that one's own perception coincides with reality and is therefore the only valid one. It is the result of naive ignorance of the world view(s by which human attitudes are shaped. By means of the ecologically congenial concepts of interrelatedness and holism, it is here argued as an alternative that social involvement is (or, should be an intrinsic part of conservation. A possible model for the purpose and some practical considerations are suggested.

  5. Cerebral involvement in acquired immunodeficiency syndrome (AIDS)

    International Nuclear Information System (INIS)

    Krestin, G.P.; Juergens, R.; Steinbrich, W.; Diederich, N.; Koeln Univ.

    1986-01-01

    Involvement of the central nervous system in acquired immune deficiency syndrome (AIDS) is usually due to opportunistic infections; these frequently offer a difficult differential diagnostic problem. Imaging methods play an important part in the elucidation of symptoms. CT and MR findings were analysed in 13 patients with AIDS and neurological symptoms. Some infections of the central nervous system (encephalitis of unknown aetiology, cytomegalic encephalitis, meningitis) may show cerebral atrophy or even no morphological changes. Toxoplasmosis and PML are the most common opportunistic infections typical changes on CT and MR may lead to diagnosis. MR offers advantages compared with CT in its higher sensitivity for the demonstration even of small lesions. (orig.) [de

  6. Involving Motion Graphics in Spatial Experience Design

    DEFF Research Database (Denmark)

    Steijn, Arthur

    2013-01-01

    elements such as e.g. space, tone, color, movement, time and timing. Developing this design model has two purposes. The first is as a tool for analyzing empirical examples or cases of where motion graphics is used in spatial experience design. The second is as a tool that can be used in the actual design...... process, and therefore it should be constructed as such. Since the development of the design model has this double focus, I involve design students in design laboratories related to my practice as a teacher in visual communication design and production design. I also reflect on how an initial design...

  7. Primary Mural Endocarditis Without Valvular Involvement.

    Science.gov (United States)

    Tahara, Mai; Nagai, Tomoo; Takase, Yoshiyuki; Takiguchi, Shunichi; Tanaka, Yoshiaki; Kunihara, Takashi; Arakawa, Junko; Nakaya, Kazuhiro; Hamabe, Akira; Gatate, Youdou; Kujiraoka, Takehiko; Tabata, Hirotsugu; Katsushika, Shuichi

    2017-03-01

    Primary mural endocarditis is an extremely rare infection in which nonvalvular endocardial involvement is seen without any cardiac structural abnormalities such as ventricular septal defects. The rapid and precise diagnosis of this disease remains challenging. We present 2 cases (67- and 47-year-old male patients) of pathologically confirmed primary mural endocarditis that could have been detected by initial transthoracic echocardiography in the emergency department. Transthoracic echocardiography and transesophageal echocardiography play critical roles in the early recognition and confirmation of primary mural endocarditis. © 2017 by the American Institute of Ultrasound in Medicine.

  8. Involvement of Autophagy in Coronavirus Replication

    Directory of Open Access Journals (Sweden)

    Paul Britton

    2012-11-01

    Full Text Available Coronaviruses are single stranded, positive sense RNA viruses, which induce the rearrangement of cellular membranes upon infection of a host cell. This provides the virus with a platform for the assembly of viral replication complexes, improving efficiency of RNA synthesis. The membranes observed in coronavirus infected cells include double membrane vesicles. By nature of their double membrane, these vesicles resemble cellular autophagosomes, generated during the cellular autophagy pathway. In addition, coronavirus infection has been demonstrated to induce autophagy. Here we review current knowledge of coronavirus induced membrane rearrangements and the involvement of autophagy or autophagy protein microtubule associated protein 1B light chain 3 (LC3 in coronavirus replication.

  9. Extracellular Molecules Involved in Cancer Cell Invasion

    International Nuclear Information System (INIS)

    Stivarou, Theodora; Patsavoudi, Evangelia

    2015-01-01

    Nowadays it is perfectly clear that understanding and eradicating cancer cell invasion and metastasis represent the crucial, definitive points in cancer therapeutics. During the last two decades there has been a great interest in the understanding of the extracellular molecular mechanisms involved in cancer cell invasion. In this review, we highlight the findings concerning these processes, focusing in particular on extracellular molecules, including extracellular matrix proteins and their receptors, growth factors and their receptors, matrix metalloproteinases and extracellular chaperones. We report the molecular mechanisms underlying the important contribution of this pool of molecules to the complex, multi-step phenomenon of cancer cell invasion

  10. Extracellular Molecules Involved in Cancer Cell Invasion

    Directory of Open Access Journals (Sweden)

    Theodora Stivarou

    2015-01-01

    Full Text Available Nowadays it is perfectly clear that understanding and eradicating cancer cell invasion and metastasis represent the crucial, definitive points in cancer therapeutics. During the last two decades there has been a great interest in the understanding of the extracellular molecular mechanisms involved in cancer cell invasion. In this review, we highlight the findings concerning these processes, focusing in particular on extracellular molecules, including extracellular matrix proteins and their receptors, growth factors and their receptors, matrix metalloproteinases and extracellular chaperones. We report the molecular mechanisms underlying the important contribution of this pool of molecules to the complex, multi-step phenomenon of cancer cell invasion.

  11. Peripheral nerve involvement in Bell's palsy

    Directory of Open Access Journals (Sweden)

    J. A. Bueri

    1984-12-01

    Full Text Available A group of patients with Bell's palsy were studied in order to disclose the presence of subclinical peripheral nerve involvement. 20 patients, 8 male and 12 female, with recent Bell's palsy as their unique disease were examined, in all cases other causes of polyneuropathy were ruled out. Patients were investigated with CSF examination, facial nerve latencies in the affected and in the sound sides, and maximal motor nerve conduction velocities, as well as motor terminal latencies from the right median and peroneal nerves. CSF laboratory examination was normal in all cases. Facial nerve latencies were abnormal in all patients in the affected side, and they differed significantly from those of control group in the clinically sound side. Half of the patients showed abnormal values in the maximal motor nerve conduction velocities and motor terminal latencies of the right median and peroneal nerves. These results agree with previous reports which have pointed out that other cranial nerves may be affected in Bell's palsy. However, we have found a higher frequency of peripheral nerve involvement in this entity. These findings, support the hypothesis that in some patients Bell's palsy is the component of a more widespread disease, affecting other cranial and peripheral nerves.

  12. Community involvement in dam breach exercises

    International Nuclear Information System (INIS)

    Cattanach, J.D.; Macdonald, E.G.; Mulligan, K.M.

    1993-01-01

    In 1986 British Columbia Hydro made a commitment to perform annual dam failure simulations based on the Emergency Preparedness Plans. Over the last 7 years nine such exercises have been completed. Each year the level of complexity of the exercises has increased, and along with it, the number of organizations outside of B.C. Hydro that participate in the exercise events has also increased. There has been a shift in attitudes, both internally and externally, towards these exercises. It is described how British Columbia Hydro was able to involve the communities downstream of its dams and encourage their participation in emergency planning and coordination. B.C. Hydro's process for involving a community in its emergency exercises starts with an invitation to the emergency coordinator in each affected community to attend an exercise planning meeting. Communities have occasionally declined to participate, the most common reasons being insufficiently developed emergency plans, budget prohibiting the cost of the exercise, or for political reasons. 2 refs., 1 tab

  13. Japan's involvement in oil sands development

    International Nuclear Information System (INIS)

    Sugiura, T.

    1994-01-01

    According to Japanese national policy, exploration and development by Japanese companies in overseas countries are promoted in order to ensure stable oil supplies. Japan Canada Oil Sands Limited (JACOS), part of the JAPEX group, was established during the 1978 world oil crisis to explore and develop Canadian oil sand resources in accordance with Japan's national policy. The JAPEX group, including JACOS, has invested $123 million in oil sands projects in Alberta. JAPEX's first involvement in oil sands was in the Primrose Project operated by Norcen in the Cold Lake area. Five years of cyclic steam stimulation pilot tests did not produce sufficiently good results to justify further operation. The second involvement was the PCEJ Project, a joint effort by four companies that are participating in a bitumen recovery test project in the Athabasca Deposit. JACOS holds 2,452 km 2 of oil sands leases in Alberta. Tests conducted since 1978 in the PCEJ Project include multiwell steam injection pilot tests, some of which showed promise. JACOS is also participating in steam assisted gravity drainage projects and in federal/provincial research programs. Obstacles identified in developing Alberta oil sands are the lack of a bitumen pipeline to Edmonton and the insufficient length of oil sands leases (currently 10 years), given the difficulties of oil sand development. 10 figs

  14. Involvement of hyaluronidases in colorectal cancer

    International Nuclear Information System (INIS)

    Bouga, Helen; Tsouros, Isidoros; Bounias, Dimitrios; Kyriakopoulou, Dora; Stavropoulos, Michael S; Papageorgakopoulou, Nikoletta; Theocharis, Dimitrios A; Vynios, Demitrios H

    2010-01-01

    Hyaluronidases belong to a class of enzymes that degrade, predominantly, hyaluronan. These enzymes are known to be involved in physiological and pathological processes, such as tumor growth, infiltration and angiogenesis, but their exact role in tumor promotion or suppression is not clear yet. Advanced colorectal cancer is associated with elevated amounts of hyaluronan of varying size. The aim of the present study was therefore to illuminate the importance of hyaluronidases in colon carcinoma progression. The patients' samples (macroscopically normal and cancerous) were subjected to sequential extraction with PBS, 4 M GdnHCl and 4 M GdnHCl - 1% Triton X-100. The presence of the various hyaluronidases in the extracts was examined by zymography and western blotting. Their expression was also examined by RT-PCR. Among hyaluronidases examined, Hyal-1, -2, -3 and PH-20 were detected. Their activity was higher in cancerous samples. Hyal-1 and Hyal-2 were overexpressed in cancerous samples, especially in advanced stages of cancer. Both isoforms were mainly extracted with PBS. Hyal-3 was observed only in the third extract of advanced stages of cancer. PH-20 was abundant in all three extracts of all stages of cancer. The expression of only Hyal-1 and PH-20 was verified by RT-PCR. A high association of hyaluronidases in colorectal cancer was observed. Each hyaluronidase presented different tissue distribution, which indicated the implication of certain isoforms in certain cancer stages. The results provided new evidence on the mechanisms involved in the progression of colorectal cancer

  15. Truck accident involving unirradiated nuclear fuel

    International Nuclear Information System (INIS)

    Carlson, R.W.; Fischer, L.E.

    1992-07-01

    In the early morning of Dec. 16, 1991, a severe accident occurred when a passenger vehicle traveling in the wrong direction collided with a tractor trailer carrying 24 nuclear fuel assemblies in 12 containers on Interstate 1-91 in Springfield, Massachusetts. This paper documents the mechanical circumstances of the accident and the physical environment to which the containers were exposed and the response of the containers and their contents. The accident involved four impacts where the truck was struck by the car, impacted on the center guardrail, impacted on the outer concrete barrier and came to rest against the center guardrail. The impacts were followed by a fire that began in the engine compartment, spread to the.tractor and cab, and eventually spread to the trailer and payload. The fire lasted for about three hours and the packages were involved in the fire for about two hours. As a result of the fire, the tractor-trailer was completely destroyed and the packages were exposed to flames with temperatures between 1300 degrees F and 1800 degrees F. The fuel assemblies remained intact during the accident and there was no release of any radioactive material during the accident. This was a very severe accident; however, the injuries were minor and at no time was the public health and safety at risk

  16. Cardiovascular Involvement in Children with Osteogenesis Imperfecta

    Science.gov (United States)

    Karamifar, Hamdollah; Ilkhanipoor, Homa; Ajami, Gholamhossein; Karamizadeh, Zohreh; Amirhakimi, Gholamhossein; Shakiba, Ali-Mohammad

    2013-01-01

    Objective Osteogenesis imperfecta is a hereditary disease resulting from mutation in type I procollagen genes. One of the extra skeletal manifestations of this disease is cardiac involvement. The prevalence of cardiac involvement is still unknown in the children with osteogenesis imperfecta. The present study aimed to investigate the prevalence of cardiovascular abnormalities in these patients. Methods 24 children with osteogenesis imperfecta and 24 normal children who were matched with the patients regarding sex and age were studied. In both groups, standard echocardiography was performed, and heart valves were investigated. Dimensions of left ventricle, aorta annulus, sinotubular junction, ascending and descending aorta were measured and compared between the two groups. Findings The results revealed no significant difference between the two groups regarding age, sex, ejection fraction, shortening fraction, mean of aorta annulus, sinotubular junction, ascending and descending aorta, but after correction based on the body surface area, dimensions of aorta annulus, sinotubular junction, ascending and descending aorta in the patients were significantly higher than those in the control group (P25 mmHg and one patient had pulmonary insufficiency with indirect evidence of pulmonary hypertension. According to Z scores of aorta annulus, sinotubular junction and ascending aorta, 5, 3, and 1 out of 24 patients had Z scores >2 respectively. Conclusion The prevalence of valvular heart diseases and aortic root dilation was higher in children with osteogenesis imperfecta. In conclusion, cardiovascular investigation is recommended in these children. PMID:24800009

  17. Comprehension of Action Negation Involves Inhibitory Simulation

    Directory of Open Access Journals (Sweden)

    Francesco eForoni

    2013-05-01

    Full Text Available Previous research suggests that action language is comprehended by activating the motor system. We report a study, investigating a critical question in this research field: Do negative sentences activate the motor system? Participants were exposed to sentences in the affirmation and negation forms while the zygomatic muscle activity on the left side of the face was continuously measured (Electromyography technique: EMG. Sentences were descriptions of emotional expressions that mapped either directly upon the zygomatic muscle (e.g., ‘I am smiling’ or did not (e.g., ‘I am frowning’. Reading sentences involving the negation of the activity of a specific muscle (zygomatic major - I am not smiling is shown to lead to the inhibition of this muscle. Reading sentences involving the affirmative form instead (I am smiling leads to the activation of zygomatic mucle. In contrast, sentences describing an activity that is irrelevant to the zygomatic muscle (e.g., ‘I am frowning’ or ‘I am not frowning’ produce no muscle activity. These results extend the range of simulation models to negation and by implication to an abstract domain. We discuss how this research contributes to the grounding of abstract and concrete concepts.

  18. Childhood AIDS: pulmonary involvement. Clinico radiological correlation

    International Nuclear Information System (INIS)

    Cinta, C.; Muro, D.; Perez, A.; Otero, M.C.

    1997-01-01

    To determine the different radiological findings in the lung of children presenting human ummunodeficiency virus (HIV) infection. We assess the different radiological patterns and their prevalence. The study deals with 58 children presenting HIV infection. All underwent plain chest radiography at some time during the course of their disease to determine the cause of different respiratory symptoms (dyspnea, fever, cough, etc.).Bronchial lavage was performed in all the children who required intubation due to severe respiratory distress. The results of chest X-ray were normal in 29 children despite the existence of pulmonary symptomatology. The other 29 patients presented pulmonary, including 21 cases of pneumonia (36,2%) in 16 patients, in seven of whom the pathogen was determined by blood culture. Four cases of Pneumocystis carinii (6.89%) were diagnosed by means of bronchial lavage. There were nine children with interstitial pneumonitis, five of the lym-phoid variant (8.62%) and four of unknown origin (6.89%). In contrast to the findings in adults, we have had no cases of pulmonary tuberculosis among our patients The rates of morbidity and mortality among HIV-infected children are associated with lung involvement. However, the prevalence has decreased progressively since the introduction of antiviral agents. Recurrent bacterial pneumonia and opportunistic Pneumocystis carinii infection are the most common types of acute pulmonary involvement. Interstitial pneumonitis usually develops a chronic course. (Author) 15 refs

  19. Fusion excitation functions involving transitional nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Rehm, K.E.; Jiang, C.L.; Esbensen, H. [and others

    1995-08-01

    Measurements of fusion excitation functions involving transitional nuclei {sup 78}Kr and {sup 100}Mo showed a different behavior at low energies, if compared to measurements with {sup 86}Kr and {sup 92}Mo. This points to a possible influence of nuclear structure on the fusion process. One way to characterize the structure of vibrational nuclei is via their restoring force parameters C{sub 2} which can be calculated from the energy of the lowest 2{sup +} state and the corresponding B(E2) value. A survey of the even-even nuclei between A = 28-150 shows strong variations in C{sub 2} values spanning two orders of magnitude. The lowest values for C{sub 2} are observed for {sup 78}Kr, {sup 104}Ru and {sup 124}Xe followed by {sup 74,76}Ge, {sup 74,76}Se, {sup 100}Mo and {sup 110}Pd. In order to learn more about the influence of {open_quotes}softness{close_quotes} on the sub-barrier fusion enhancement, we measured cross sections for evaporation residue production for the systems {sup 78}Kr + {sup 104}Ru and {sup 78}Kr + {sup 76}Ge with the gas-filled magnet technique. For both systems, fusion excitation functions involving the closed neutron shell nucleus {sup 86}Kr were measured previously. The data are presently being analyzed.

  20. Truck accident involving unirradiated nuclear fuel

    International Nuclear Information System (INIS)

    Carlson, R.W.; Fischer, L.E.

    1993-01-01

    In the early morning of Dec. 16, 1991, a severe accident occurred when a passenger vehicle traveling in the wrong direction collided with a tractor trailer carrying 24 unirradiated nuclear fuel assemblies in 12 containers on Interstate I-91 in Springfield, Massachusetts. This paper documents the mechanical circumstances of the accident and assesses the physical environment to which the containers were exposed and the response of the containers and their contents. The accident involved four impacts where the truck was struck by the car, impacted on the center guardrail, impacted on the outer concrete barrier and came to rest against the center guardrail. The impacts were followed by a fire that began in the engine compartment, spread to the tractor and cab, and eventually spread to the trailer and payload. The fire lasted for about three hours and the packages were involved in the fire for about two hours. As a result of the fire, the tractor-trailer was completely destroyed and the packages were exposed to flames with temperatures between 1,300 F and 1,800 F. The fuel assemblies remained intact during the accident and there was no release of any radioactive material during the accident. This was a very severe accident; however, the injuries were minor and at no time was the public health and safety at risk

  1. Lessons learned in NEPA public involvement

    International Nuclear Information System (INIS)

    Stevens, A.D.; Glore, D.M.

    1995-01-01

    'In recent years Uncle Sam has been asking citizens for their help in improving the environment. The government is learning that with public input it can better prioritize environmental problems and more effectively direct limited funding.' The National Environmental Policy Act (NEPA), like many other government regulations, is a 'living law.' Although there are agency and Council guidelines, it is practical application, based on past practices and case law that refines the Act's broad concepts. The specifics of how to meet requirements are constantly being honed and melded to fit the unique situational needs of an agency, a project, or a public. This fluidity presents a challenge for stakeholder involvement activities. Communication practioners and project managers may have room for creativity and customized approaches, but they also find less than clear direction on what it takes to successfully avoid challenges of non-compliance. Because of the continuing uncertainty on how to involve the public meaningfully, it is vital to share important lessons learned from NEPA projects. The following practical suggestions are derived primarily from experiences with the Department of Energy's first ever complex-wide and site-specific environmental impact statement (EIS)-the Programmatic Spent Nuclear Fuel Management and Idaho National Engineering Laboratory Environmental Restoration and Waste Management Programs EIS (SNF ampersand INEL EIS)

  2. Breadth and depth involvement: Understanding Internet gambling involvement and its relationship to gambling problems.

    Science.gov (United States)

    LaPlante, Debi A; Nelson, Sarah E; Gray, Heather M

    2014-06-01

    The "involvement effect" refers to the finding that controlling for gambling involvement often reduces or eliminates frequently observed game-specific associations with problem gambling. In other words, broader patterns of gambling behavior, particularly the number of types of games played over a defined period, contribute more to problem gambling than playing specific games (e.g., lottery, casino, Internet gambling). This study extends this burgeoning area of inquiry in three primary ways. First, it tests independently and simultaneously the predictive power of two gambling patterns: breadth involvement (i.e., the number of games an individual plays) and depth involvement (i.e., the number of days an individual plays). Second, it includes the first involvement analyses of actual betting activity records that are associated with clinical screening information. Third, it evaluates and compares the linearity of breadth and depth effects. We conducted analyses of the actual gambling activity of 1,440 subscribers to the bwin.party gambling service who completed an online gambling disorder screen. In all, 11 of the 16 games we examined had a significant univariate association with a positive screen for gambling disorder. However, after controlling for breadth involvement, only Live Action Internet sports betting retained a significant relationship with potential gambling-related problems. Depth involvement, though significantly related to potential problems, did not impact game-based gambling disorder associations as much as breadth involvement. Finally, breadth effects appeared steeply linear, with a slight quadratic component manifesting beyond four games played, but depth effects appeared to have a strong linear component and a slight cubic component.

  3. Comparison of Higher Fashion Involvement Group and Lower Fashion Involvement Group in Taiwan

    OpenAIRE

    Huang, Yu-Chiao

    2013-01-01

    Fashion collaboration becomes a common marketing strategy for many fashion brands in order to attract consumers’ attentions and stand out from competitors. The purpose of this dissertation is to explore the formation of consumers’ attitudes toward fashion collaboration. First, it intends to distinguish different types of consumers, which are higher fashion involvement and lower fashion involvement. Second, by utiliseing four different variables, which are prior attitudes, product fit, brand, ...

  4. Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis

    Science.gov (United States)

    Nakazawa, Seshiru; Oikawa, Daisuke; Ishii, Ryohei; Ayaki, Takashi; Takahashi, Hirotaka; Takeda, Hiroyuki; Ishitani, Ryuichiro; Kamei, Kiyoko; Takeyoshi, Izumi; Kawakami, Hideshi; Iwai, Kazuhiro; Hatada, Izuho; Sawasaki, Tatsuya; Ito, Hidefumi; Nureki, Osamu; Tokunaga, Fuminori

    2016-01-01

    Optineurin (OPTN) mutations cause neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and glaucoma. Although the ALS-associated E478G mutation in the UBAN domain of OPTN reportedly abolishes its NF-κB suppressive activity, the precise molecular basis in ALS pathogenesis still remains unclear. Here we report that the OPTN-UBAN domain is crucial for NF-κB suppression. Our crystal structure analysis reveals that OPTN-UBAN binds linear ubiquitin with homology to NEMO. TNF-α-mediated NF-κB activation is enhanced in OPTN-knockout cells, through increased ubiquitination and association of TNF receptor (TNFR) complex I components. Furthermore, OPTN binds caspase 8, and OPTN deficiency accelerates TNF-α-induced apoptosis by enhancing complex II formation. Immunohistochemical analyses of motor neurons from OPTN-associated ALS patients reveal that linear ubiquitin and activated NF-κB are partially co-localized with cytoplasmic inclusions, and that activation of caspases is elevated. Taken together, OPTN regulates both NF-κB activation and apoptosis via linear ubiquitin binding, and the loss of this ability may lead to ALS. PMID:27552911

  5. Stake holders involvement in emergency preparedness

    International Nuclear Information System (INIS)

    Oudiz, A.

    2002-01-01

    The management of a nuclear crisis involves many actors apart from the radiation protection and nuclear safety experts. More than stakeholders involvement, what is at stake is a better co-operation and mutual understanding amongst the various actors. This mutual understanding requires that a minimal common nuclear risk culture exists. Presently, in France, the representation of the nuclear risk is split into two clear-cut misconceptions: risk denial or catastrophe, with almost nothing in between. In order to contribute to building progressively a common nuclear risk culture, the information about the risk and its management needs to be discussed and criticized by various actors, including non institutional actors who play an important role for the diffusion of the risk culture. Hence, IPSN decided in year 2000 to elaborate a specific feature allowing information and debate on the nuclear risk and its short and long terms management. It will take the form of a CD-ROM, which is currently elaborated by a task group taking into account: - the 'social expectancies', as they have been identified by a sociologist, - the available documents about the nuclear risk, the crisis and its management, which were analysed. The analysis shows that there is a need for a new type of feature. The feature contains first a common bulk which addresses all types of nuclear accidents and then, specific developments for each type of accidents occurring in different nuclear installations. Specialists in CD-ROM design are involved in the project. It is very important to design the structure of the CD-ROM in such a way as it presents the technical information in an understandable manner for non-specialists. This CD-ROM, which should be widely distributed and will serve as a support for debates, may contribute to building up progressively a common risk culture. It should help to aim at a better mutual understanding between experts and lay people whose points of view about the nuclear risk

  6. Parent Involvement and Student Performance: The Influence of School Context

    Science.gov (United States)

    McNeal, Ralph B., Jr.

    2015-01-01

    Researchers focusing on parent involvement continue to concentrate their efforts on the relationship between involvement and student performance in isolation of the school context in which involvement occurs. This research outlines an ecology of involvement and how this social context affects parent involvement and student performance. Relying on…

  7. Apolipoprotein gene involved in lipid metabolism

    Science.gov (United States)

    Rubin, Edward; Pennacchio, Len A.

    2007-07-03

    Methods and materials for studying the effects of a newly identified human gene, APOAV, and the corresponding mouse gene apoAV. The sequences of the genes are given, and transgenic animals which either contain the gene or have the endogenous gene knocked out are described. In addition, single nucleotide polymorphisms (SNPs) in the gene are described and characterized. It is demonstrated that certain SNPs are associated with diseases involving lipids and triglycerides and other metabolic diseases. These SNPs may be used alone or with SNPs from other genes to study individual risk factors. Methods for intervention in lipid diseases, including the screening of drugs to treat lipid-related or diabetic diseases are also disclosed.

  8. Scaling Consumers' Purchase Involvement: A New Approach

    Directory of Open Access Journals (Sweden)

    Jörg Kraigher-Krainer

    2012-06-01

    Full Text Available A two-dimensional scale, called ECID Scale, is presented in this paper. The scale is based on a comprehensive model and captures the two antecedent factors of purchase-related involvement, namely whether motivation is intrinsic or extrinsic and whether risk is perceived as low or high. The procedure of scale development and item selection is described. The scale turns out to perform well in terms of validity, reliability, and objectivity despite the use of a small set of items – four each – allowing for simultaneous measurements of up to ten purchases per respondent. The procedure of administering the scale is described so that it can now easily be applied by both, scholars and practitioners. Finally, managerial implications of data received from its application which provide insights into possible strategic marketing conclusions are discussed.

  9. Endolymphatic sac involvement in bacterial meningitis

    DEFF Research Database (Denmark)

    Møller, Martin Nue; Brandt, Christian; Østergaard, Christian

    2015-01-01

    The commonest sequelae of bacterial meningitis are related to the inner ear. Little is known about the inner ear immune defense. Evidence suggests that the endolymphatic sac provides some protection against infection. A potential involvement of the endolymphatic sac in bacterial meningitis...... is largely unaccounted for, and thus the object of the present study. A well-established adult rat model of Streptococcus pneumoniae meningitis was employed. Thirty adult rats were inoculated intrathecally with Streptococcus pneumoniae and received no additional treatment. Six rats were sham...... days. Bacteria invaded the inner ear through the cochlear aquaduct. On days 5-6, the bacteria invaded the endolymphatic sac through the endolymphatic duct subsequent to invasion of the vestibular endolymphatic compartment. No evidence of direct bacterial invasion of the sac through the meninges...

  10. Interactive emergency communication involving persons in crisis.

    Science.gov (United States)

    Nordby, Halvor; Nøhr, Øyvind

    2009-01-01

    We studied the dialogue between telephone operators at medical emergency communication centres in Norway and parents of children later diagnosed with sudden infant death syndrome. The aim was to understand how the parents experienced the communication with the telephone operators. The qualitative method involved semi-structured interviews. We interviewed six respondents from urban areas and five from rural areas. An important finding was that all the parents were satisfied with the resuscitation instructions they received. It was also perceived as important that the emergency operators expressed empathy and care. We believe that it is not merely the quality of the resuscitation attempts that the operators' efforts should be measured against. It is also important that the operators provide good explanations and express emotional support. Our findings indicate that this will be enormously appreciated, even if callers do not feel that they are capable of performing optimum resuscitation.

  11. Complementarities Between Employee Involvement and Financial Participation

    DEFF Research Database (Denmark)

    Jones, Derek C.; Kalmi, Panu; Kato, Takao

    2016-01-01

    The authors investigate whether productivity is greater if firms use employee involvement (EI) in decision making and financial participation (FP) as complementary practices. Based on representative panel data from Finnish manufacturing firms, the study uses diverse specifications to examine...... different theoretical explanations of the productivity effects of complementarities. The authors find virtually no evidence to support the theory of complementarities when EI and FP are simply measured by their incidence. They do find some evidence for complementarities using cross-sectional data...... (controlling for several covariates that related work has found to be important for firm performance) and also when analyses use measures of the intensity of FP. In accounting for differences in empirical findings across varying settings, the findings suggest that outcomes depend on the institutional context...

  12. A fatal poisoning involving 2-fluorofentanyl

    DEFF Research Database (Denmark)

    Andreasen, Mette Findal; Hardlei, Tore Forsingdal; Rosendal, Ingrid

    Background/introduction: A fatal intoxication involving 2-fluorofentanyl, a potent synthetic opioid analgesic, is reported. This is the first serious case associated with 2-fluorofentanyl that to our knowledge have been reported. 2-fluorofentanyl is the common name for N-(2-fluorophenyl)-N-[1...... and gastric content samples were submitted for toxicological examination; all samples were screened by ultra-performance liquid chromatography high-resolution time-of-flight mass spectrometry (UPLC-HR-TOFMS) and quantified by specific UPLC-MS/MS methods. Powder recovered from the scene of death was identified......-mortem femoral blood concentrations found were: 2-fluorofentanyl 0.012 mg/kg (UPLC-MS/MS); alcohol production as the body was moderate decomposed; buprenorphine 0.0004 mg/kg (UPLC-MS/MS) prescribed; quetiapine 0.088 mg/kg (UPLC-MS/MS) prescribed; venlafaxine 0.089 mg...

  13. Peculiar chondroblastoma involving multiple tarsal bones

    International Nuclear Information System (INIS)

    Fukunaga, Masaharu; Asanuma, Kazuo; Irie, Takeo

    2010-01-01

    A case of peculiar chondroblastoma involving multiple tarsal bones in a 49-year-old woman is described. The patient presented with pain and swelling of the right foot. Radiographs revealed a lytic expansile lesion of medial, intermediate, and lateral cuneiform bones, navicular, cuboid, and tarsal bones of the right foot, indicating a malignant tumor. Biopsies demonstrated a diffuse proliferation of round cells with eccentric and indented nuclei with longitudinal grooves and eosinophilic cytoplasm. Atypia was prominent, but mitotic figures were rare. The stroma was chondroid with focal chicken-wire calcification. On electron microscopy, the tumor exhibited chondroblastic features. The patient is alive with the tumor 7 years after radiotherapy. The tumor is considered a chondroblastoma with low malignant potential. (orig.)

  14. Concrescent triplets involving primary anterior teeth

    Directory of Open Access Journals (Sweden)

    Urvashi Sharma

    2013-01-01

    Full Text Available Odontogenesis is a complex process wherein more than 200 genes are known to play a significant role in tooth development. An imbalance can lead to an abnormality in the number, size, shape or structure of the developing tooth/teeth. The presence of an extra dental lamina forms a supernumerary tooth. The supernumerary teeth are of two types: A rudimentary tooth where the supernumerary tooth does not resemble any tooth in the normal series or a supplemental tooth in which this anomalous tooth resembles one in the normal series. It is also very rare to encounter triple teeth in primary dentition. The union of these teeth may be through fusion, gemination, concrescence or a combination of fusion and gemination. Presented is a rare case of concrescence involving maxillary deciduous incisors and a supplemental tooth in a 7-year-old boy. The differential diagnosis, etiology, and complications of primary anterior triple teeth are discussed.

  15. Recurrent respiratory papillomatosis with pulmonary involvement

    International Nuclear Information System (INIS)

    Ikawa, Marcos Hiroyuki

    2008-01-01

    A five-year-old girl developed hoarseness with gradual worsening at the age of eight months. Three months later, she underwent bronchoscopy in which papillomas in the vocal cords, larynx and trachea were observed. Because of serious bronchospasm crises and respiratory failure, she needed several hospitalizations, definitive tracheostomy and multiple endoscopic procedures for papilloma excision. The most recent chest radiography (Figure A) and computed tomography (CT) scans (Figures B and C) showed a nodule inside the trachea and multiple pulmonary nodules, cysts and consolidations. The anatomopathological findings from curettage of the lesions revealed benign squamous-cell papillomas. Recurrent respiratory papillomatosis (RRP) is directly related to the human papillomavirus (HPV). Its spread to the lower airways is uncommon, with involvement of trachea and/or proximal bronchi in 5% of the patients, and extension to the lungs in only 1% of the cases. (author)

  16. Peculiar chondroblastoma involving multiple tarsal bones

    Energy Technology Data Exchange (ETDEWEB)

    Fukunaga, Masaharu [Jikei University School of Medicine, Department of Pathology, Tokyo (Japan); the Jikei University Daisan Hospital, Department of Pathology, Tokyo (Japan); Asanuma, Kazuo [Jikei University School of Medicine, Department of Orthopedic Surgery, Tokyo (Japan); Irie, Takeo [Jikei University School of Medicine, Department of Radiology, Tokyo (Japan)

    2010-07-15

    A case of peculiar chondroblastoma involving multiple tarsal bones in a 49-year-old woman is described. The patient presented with pain and swelling of the right foot. Radiographs revealed a lytic expansile lesion of medial, intermediate, and lateral cuneiform bones, navicular, cuboid, and tarsal bones of the right foot, indicating a malignant tumor. Biopsies demonstrated a diffuse proliferation of round cells with eccentric and indented nuclei with longitudinal grooves and eosinophilic cytoplasm. Atypia was prominent, but mitotic figures were rare. The stroma was chondroid with focal chicken-wire calcification. On electron microscopy, the tumor exhibited chondroblastic features. The patient is alive with the tumor 7 years after radiotherapy. The tumor is considered a chondroblastoma with low malignant potential. (orig.)

  17. Determinants of Parent Involvement in Romanian Schools

    Directory of Open Access Journals (Sweden)

    Diana Damean

    2010-12-01

    Full Text Available The paper is focused on exploring the factors that facilitate parent involvement in their child’s education and school life. A sample of 670 Romanian school principals from the Cross-National Survey of School Principals in South East Europe (SEE countries 2008 was used. Two-step linear regressions were run in order to predict parent participation in school meetings, parent engagement in school activities and parent influence in school governance, as reported by school principals. The results indicated that the level of parents’ organizations influence on school governance, school administration, and teaching methods is as important as the school background (size, location, budget, principal’s experience, and shares of vulnerable children.

  18. Tribal and stakeholder involvement in systems analysis

    International Nuclear Information System (INIS)

    McClure, L.; Swartz, G.; Cooley, C.

    1997-01-01

    Beginning in early 1995, U.S. Department of Energy began an experiment to link tribal and stakeholder representatives into technology assessment activities related to an Integrated Nonthermal Treatment System (INTS) study. The INTS study moved outside the framework of after-the-fact public involvement by providing the opportunity for technical and non-technical stakeholders alike to work together in the early predecision stages of the criteria development and assessment of options for innovative mixed waste treatment. The stakeholders gained an appreciation of the intense level of effort required to complete such an analysis. The engineers and scientists conducting the systems analyses had the opportunity (some for the first time) to learn more about tribal and stakeholder issues and how they might apply to the technical tasks related to technology assessment and selection

  19. Involving construction in the preliminary engineering process

    International Nuclear Information System (INIS)

    Mahoney, D.T. Jr.; Boccieri, S.V. Jr.

    1994-01-01

    With today's high cost associated with modifications in nuclear power plants, it is imperative that the authors continue to investigate ways to cut costs but at the same time improve efficiency and reduce radiation exposure to those directly associated with the implementation of modifications. The success associated with involving construction in the preliminary engineering process will not only cut costs and improve efficiency but will establish a Team Building concept to provide accountability to all those associated with the implementation of the task. This form of partnering focuses on the solutions rather than highlighting the difficulties. This paper will demonstrate techniques to implement such ideas and provide examples to corroborate actual successes already achieved

  20. Involvement of Endogenous Retroviruses in Prion Diseases

    Directory of Open Access Journals (Sweden)

    Yong-Sun Kim

    2013-08-01

    Full Text Available For millions of years, vertebrates have been continuously exposed to infection by retroviruses. Ancient retroviral infection of germline cells resulted in the formation and accumulation of inherited retrovirus sequences in host genomes. These inherited retroviruses are referred to as endogenous retroviruses (ERVs, and recent estimates have revealed that a significant portion of animal genomes is made up of ERVs. Although various host factors have suppressed ERV activation, both positive and negative functions have been reported for some ERVs in normal and abnormal physiological conditions, such as in disease states. Similar to other complex diseases, ERV activation has been observed in prion diseases, and this review will discuss the potential involvement of ERVs in prion diseases.

  1. Cerebral involvement in pseudoxanthoma elasticum; case report

    Directory of Open Access Journals (Sweden)

    Eylem Değirmenci

    2013-08-01

    Full Text Available Pseudoxanthoma elasticum (PXE is a rarely seen connective tissue disease which is characterized by progressive fragmentation and calcification of elastic fibers. Generally it is characterized by cutaneus, ocular and vascular system involvement and neurological complications are usually secondary to vascular insufficiency. 43 years old male patient had a progressive dysarthria, ataxia and vision loss which started many years ago referred to our clinic. Loose skin was seen on bilateral his axillar region and neck with atrophic, pale viola macular lesions on his body. There was “angiloid streaks” on fundus examination and skin biopsy showed calcified degenerated elastic fibers on middle and deep dermis. Diffuse white matter lesions were determined on cranial imaging. To keep in mind the diagnosis of rare diseases would be helpful in early diagnosis and treatment, reducing and even preventing systemic complications.

  2. Biomarkers for CNS involvement in pediatric lupus

    Science.gov (United States)

    Rubinstein, Tamar B; Putterman, Chaim; Goilav, Beatrice

    2015-01-01

    CNS disease, or central neuropsychiatric lupus erythematosus (cNPSLE), occurs frequently in pediatric lupus, leading to significant morbidity and poor long-term outcomes. Diagnosing cNPSLE is especially difficult in pediatrics; many current diagnostic tools are invasive and/or costly, and there are no current accepted screening mechanisms. The most complicated aspect of diagnosis is differentiating primary disease from other etiologies; research to discover new biomarkers is attempting to address this dilemma. With many mechanisms involved in the pathogenesis of cNPSLE, biomarker profiles across several modalities (molecular, psychometric and neuroimaging) will need to be used. For the care of children with lupus, the challenge will be to develop biomarkers that are accessible by noninvasive measures and reliable in a pediatric population. PMID:26079959

  3. CERTAIN PROPERTIES OF AN OPERATOR INVOLVING SUBORDINATION

    Directory of Open Access Journals (Sweden)

    Ajai P. Terwase

    2015-12-01

    Full Text Available The concept of subordination can be traced back to LindelÄof since 1909, but other mathematicians like Littlewood (1925 and Rogosinski (1939 introduced the term and developed the basic theories. Subordination now plays an important role in complex analysis. The idea of univalent subordination can be stated as follows: Let f and g be analytic in E. Then f is said to be subordinate to g, if g is univalent in E, f(0 = g(0 and every element of f(E is also an element of g(E. We denote the subordination by f≺ g. Here, we apply a lemma of Miller and Mocanu to obtain a series of best possible subordination theorems. We also make use of an operator studied by Cho and Srivastava, and by Cho and Kim in this particular work. Thus, in this research work, we consider properties of an operator aforementioned involving subordinations with new results briefly highlighted.

  4. Splenic Involvement in Hereditary Hemorrhagic Telangiectasia

    Directory of Open Access Journals (Sweden)

    Susumu Takamatsu

    2016-01-01

    Full Text Available A 33-year-old man who presented with prolonged epigastric pain was referred to our hospital. He had experienced recurrent epistaxis and had a family history of hereditary hemorrhagic telangiectasia. Computed tomography and magnetic resonance imaging revealed splenomegaly and a 9 cm hypervascular mass in his spleen. Computed tomography also showed a pulmonary arteriovenous malformation and heterogeneous enhancement of the liver parenchyma, suggesting the presence of arteriosystemic shunts and telangiectases. Based on these findings, the patient was definitely diagnosed with hereditary hemorrhagic telangiectasia according to Curaçao criteria. He underwent splenectomy, and his symptoms disappeared after surgery. Pathological examination of the resected specimen revealed that the hypervascular lesion of the spleen was not a tumor but was composed of abnormal vessels associated with hereditary hemorrhagic telangiectasia. Symptomatic splenic involvement may be a rare manifestation of hereditary hemorrhagic telangiectasia but can be revealed by imaging modalities.

  5. MicroRNA involvement in glioblastoma pathogenesis

    International Nuclear Information System (INIS)

    Novakova, Jana; Slaby, Ondrej; Vyzula, Rostislav; Michalek, Jaroslav

    2009-01-01

    MicroRNAs are endogenously expressed regulatory noncoding RNAs. Altered expression levels of several microRNAs have been observed in glioblastomas. Functions and direct mRNA targets for these microRNAs have been relatively well studied over the last years. According to these data, it is now evident, that impairment of microRNA regulatory network is one of the key mechanisms in glioblastoma pathogenesis. MicroRNA deregulation is involved in processes such as cell proliferation, apoptosis, cell cycle regulation, invasion, glioma stem cell behavior, and angiogenesis. In this review, we summarize the current knowledge of miRNA functions in glioblastoma with an emphasis on its significance in glioblastoma oncogenic signaling and its potential to serve as a disease biomarker and a novel therapeutic target in oncology.

  6. Placenta percreta with urinary bladder involvement

    International Nuclear Information System (INIS)

    Al-Ojaimi, Eftekhar H.; Subramaniam, Balameenakshi V.

    2004-01-01

    A 37-years old Pakistani lady, who had previously undergone one cesarean delivery and one uterine curettage, was admitted to the labor ward at 29 weeks of gestation with history of sudden severe painless vaginal bleeding from a sonographically diagnosed placenta pervia. An immediate cesarean was performed and a live male infant was delivered. The placenta was morbidly adherent to the lower uterine segment and attempts at removal caused torrential bleeding, necesstiating cesarean hysterectomy. In addition, attempts to dissect the bldder from lower uterine segment was unsuccessful and, hence, the diagnosis of placenta percreta with involvement of urinary bladder was made. A modified posterior approach to the hyterectomy was carried out, with subsequent good recovery. (author)

  7. RENAL INVOLVEMENT IN SUBJECTS WITH PERIPHERAL ATHEROSCLEROSIS

    International Nuclear Information System (INIS)

    FAWZY, A.; IBRAHIM, S.

    2008-01-01

    Ischemic nephropathy is an important cause of renal failure.Sub-clinical renal function abnormalities may exist in patients with extra renal atherosclerosis and may precede the onset of overt ischemic nephropathy. To assess the impact of extrarenal atherosclerosis on the kidney, the study evaluated renal function in 50 subjects with differing degrees of peripheral atherosclerosis without manifest clinical or laboratory signs of ischemic nephropathy and renovascular hypertension.All laboratory testing including total LDL and HDL-cholesterol, triglycerides, ultrasonography with Doppler analysis for the localization of peripheral vascular disease (carotid and lower limb arteries), and non-invasive evaluation of renal function by radionuclide studies of renal plasma flow (MAG3 clearance) and glomerular filtration (DTPA clearance) were determined as well as smoking habit was recorded. By combining sonographic data on arterial tree stenosis (ATS), the subjects were grouped according to the atherosclerotic vascular damage (ATS involvement). The results showed no change in plasma creatinine while DTPA clearance was increased from 91.58±26.53 to 93.47±24.82 ml/min/1.73 m. MAG3 clearance was progressively declined with the severity of vascular damage from 244.86 ± 60.60 to 173.59±58.74 ml/min/1.73 m.Stepwise, multiple regression analysis indicated that MAG3 clearance was best explained by ATS involvement (standardized B coefficient -0.40; P< 0.001), smoking habit (-0.34;P=0.004) and serum LDL-cholesterol (-0.24; P<0.035).It could be concluded that the renal hemodynamic profile in atherosclerotic patients might constitute functional evidence of the silent phase of ischemic renal disease. The findings suggest that renal function should be carefully assessed in patients with extrarenal atherosclerosis, particularly in those with classic cardiovascular risk factors

  8. Family doctors' involvement with families in Estonia

    Directory of Open Access Journals (Sweden)

    Lember Margus

    2004-10-01

    Full Text Available Abstract Background Family doctors should care for individuals in the context of their family. Family has a powerful influence on health and illness and family interventions have been shown to improve health outcomes for a variety of health problems. The aim of the study was to investigate the Estonian family doctors' (FD attitudes to the patients' family-related issues in their work: to explore the degree of FDs involvement in family matters, their preparedness for management of family-related issues and their self-assessment of the ability to manage different family-related problems. Methods A random sample (n = 236 of all FDs in Estonia was investigated using a postal questionnaire. Altogether 151 FDs responded to the questionnaire (response rate 64%, while five of them were excluded as they did not actually work as FDs. Results Of the respondents, 90% thought that in managing the health problems of patients FDs should communicate and cooperate with family members. Although most of the family doctors agreed that modifying of the health damaging risk factors (smoking, alcohol and drug abuse of their patients and families is their task, one third of them felt that dealing with these problems is ineffective, or perceived themselves as poorly prepared or having too little time for such activities. Of the respondents, 58% (n = 83 were of the opinion that they could modify also relationship problems. Conclusions Estonian family doctors are favourably disposed to involvement in family-related problems, however, they need some additional training, especially in the field of relationship management.

  9. Parent involvement when developing health education programmes

    Directory of Open Access Journals (Sweden)

    Holger Hassel

    2008-03-01

    Full Text Available

    Background: The problem of obesity in children and adults has been widely recognised and described in the literature [1]. There are several challenges leading to an augmentation of the problem. Firstly, the aetiology of overweight and obesity is not clear. Secondly, the long term effectiveness of prevention programmes is low. Only in some groups and for a short period of time an effect may be visible [2]. Thirdly, little is known about what children should learn when [3]. A proper concept of educating children in regard to healthy eating or physical activity does not exist. As far as we know an essential pre-requisite for health education programmes is that they are lifestyleoriented and easily transferable into daily family life [4]. For this, working together with the parents would be essential. The main goal of this article will be 1 to get a better understanding of what parents and nurses/ teachers want 2 to strengthen the point that this method is one way to involve the target groups and thus it is likely to increase the acceptance of health education programmes 3 to describe that focus group discussions are a useful tool to identify the opinions of the target group.

    Methods: In the frame of three projects, focus groups with nurses/ teachers and parents have been carried out.

    Results and Conclusions: Results from different focus group discussions with pedagogues and parents will be discussed and conclusions for health education programmes relevant to all key players involved will be identified.

  10. Temporomandibular joint involvement caused by Borrelia Burgdorferi.

    Science.gov (United States)

    Lesnicar, Gorazd; Zerdoner, Danijel

    2007-12-01

    Lyme borreliosis is an endemic disease in Slovenia with an incidence of around 150 patients per 100,000 inhabitants. Although the large joints are most typically affected in Lyme borreliosis, there are also periods of disease activity with arthritis or arthralgias involving smaller joints, including the temporo-mandibular joint. During the years between 2000 and 2003, two patients with Lyme borreliosis affecting the temporo-mandibular joints were treated. The patients presented with fatigue and pain in diverse muscle groups accompanied by arthralgia, which was most pronounced in the temporomandibular joint area. None of the patients were febrile or had joint effusions. Both patients were examined by means of biochemical and serological examinations for Borrelia burgdorferi using ELISA assay and Western blot test (both for IgM and IgG), plain radiographs, MR and CT scans, and scinti-scan of the temporo-mandibular joints They both had positive serum markers for an acute B. burgdorferi infection and were treated with intravenous ceftriaxone. None of the patients had clinical or laboratory signs of chronic Lyme disease activity two and four years following therapy, respectively. Roentgenographic and nuclear magnetic resonance imaging of the temporo-mandibular joints had not shown any persistent sign of acute inflammation. There are only few reports of patients with manifest temporo-mandibular joint involvement of Lyme borreliosis in the literature. This report emphasizes the importance of differential diagnosis of acute temporo-mandibular joint arthralgia, of early diagnosis of Lyme borreliosis, and of the necessity for prompt antibiotic treatment.

  11. Neurobiological mechanisms involved in sleep bruxism.

    Science.gov (United States)

    Lavigne, G J; Kato, T; Kolta, A; Sessle, B J

    2003-01-01

    Sleep bruxism (SB) is reported by 8% of the adult population and is mainly associated with rhythmic masticatory muscle activity (RMMA) characterized by repetitive jaw muscle contractions (3 bursts or more at a frequency of 1 Hz). The consequences of SB may include tooth destruction, jaw pain, headaches, or the limitation of mandibular movement, as well as tooth-grinding sounds that disrupt the sleep of bed partners. SB is probably an extreme manifestation of a masticatory muscle activity occurring during the sleep of most normal subjects, since RMMA is observed in 60% of normal sleepers in the absence of grinding sounds. The pathophysiology of SB is becoming clearer, and there is an abundance of evidence outlining the neurophysiology and neurochemistry of rhythmic jaw movements (RJM) in relation to chewing, swallowing, and breathing. The sleep literature provides much evidence describing the mechanisms involved in the reduction of muscle tone, from sleep onset to the atonia that characterizes rapid eye movement (REM) sleep. Several brainstem structures (e.g., reticular pontis oralis, pontis caudalis, parvocellularis) and neurochemicals (e.g., serotonin, dopamine, gamma aminobutyric acid [GABA], noradrenaline) are involved in both the genesis of RJM and the modulation of muscle tone during sleep. It remains unknown why a high percentage of normal subjects present RMMA during sleep and why this activity is three times more frequent and higher in amplitude in SB patients. It is also unclear why RMMA during sleep is characterized by co-activation of both jaw-opening and jaw-closing muscles instead of the alternating jaw-opening and jaw-closing muscle activity pattern typical of chewing. The final section of this review proposes that RMMA during sleep has a role in lubricating the upper alimentary tract and increasing airway patency. The review concludes with an outline of questions for future research.

  12. Employee suggestion programs: the rewards of involvement.

    Science.gov (United States)

    Mishra, J M; McKendall, M

    1993-09-01

    Successful ESPs are the products of a great deal of effort by managers, administrators, teams, individuals, and reviewers, who are all striving to achieve the goals of increased profitability and enhanced employee involvement. A review of the literature indicates that there are several prescriptions that will increase the likelihood of a successful ESP (see the box). Today's American business prophets sound ceaseless calls to arms in the name of "world class performance," "global competitiveness," "total quality management," and a variety of other buzz terms. A burgeoning industry has evolved that promises, through speeches, teleconferences, seminars, and consulting contracts, to teach American organizations how to achieve excellence. In the face of a sputtering economy and unrelenting competitive pressure, today's managers must translate these laudatory ideals into hands-on reality without sacrificing the firm's profit margin to experimentation. If any idea can help an organization achieve improvement through a workable program, then that idea and that program deserve real consideration. An ESP represents an opportunity to tap the intelligence and resourcefulness of an organization's employees, and by doing so, reap significant cost savings. Those companies and managers that have an ESP program uniformly list economic advantages first when describing the benefits of their employee suggestion programs. But there is another deeper and longer term benefit inherent in an ESP. These programs allow employees to become involved in their organization; they drive deaccession to lower levels, they give employees more responsibility, they foster creative approaches to work, and they encourage creativity in pursuit of company goals.(ABSTRACT TRUNCATED AT 250 WORDS)

  13. Potential for Australian involvement in ITER

    International Nuclear Information System (INIS)

    O'Connor, D. J.; Collins, G. A.; Hole, M. J.

    2006-01-01

    Full text: Full text: Fusion, the process that powers the sun and stars, offers a solution to the world's long-term energy needs: providing large scale energy production with zero greenhouse gas emissions, short-lived radio-active waste compared to conventional nuclear fission cycles, and a virtually limitless supply of fuel. Almost three decades of fusion research has produced spectacular progress. Present-day experiments have a power gain ratio of approximately 1 (ratio of power out to power in), with a power output in the 10's of megawatts. The world's next major fusion experiment, the International Thermonuclear Experimental Reactor (ITER), will be a pre-prototype power plant. Since announcement of the ITER site in June 2005, the ITER project, has gained momentum and political support. Despite Australia's foundation role in the field of fusion science, through the pioneering work of Sir Mark Oliphant, and significant contributions to the international fusion program over the succeeding years, Australia is not involved in the ITER project. In this talk, the activities of a recently formed consortium of scientists and engineers, the Australian ITER Forum will be outlined. The Forum is drawn from five Universities, ANSTO (the Australian Nuclear Science and Technology Organisation) and AINSE (the Australian Institute for Nuclear Science and Engineering), and seeks to promote fusion energy in the Australian community and negotiate a role for Australia in the ITER project. As part of this activity, the Australian government recently funded a workshop that discussed the ways and means of engaging Australia in ITER. The workshop brought the research, industrial, government and general public communities, together with the ITER partners, and forged an opportunity for ITER engagement; with scientific, industrial, and energy security rewards for Australia. We will report on the emerging scope for Australian involvement

  14. Suicide and Murder-Suicide Involving Aircraft.

    Science.gov (United States)

    Kenedi, Christopher; Friedman, Susan Hatters; Watson, Dougal; Preitner, Claude

    2016-04-01

    This is a systematic review of suicide and homicide-suicide events involving aircraft. In aeromedical literature and in the media, these very different events are both described as pilot suicide, but in psychiatry they are considered separate events with distinct risk factors. Medical databases, internet search engines, and aviation safety databases were searched in a systematic way to obtain relevant cases. Relevant articles were searched for additional references. There were 65 cases of pilot suicide and 6 cases of passengers who jumped from aircraft found. There were also 18 cases of homicide-suicide found involving 732 deaths. Pilots perpetrated 13 homicide-suicide events. Compared to non-aviation samples, a large percentage of pilot suicides in this study were homicide-suicides (17%). Homicide-suicide events occur extremely rarely. However, their impact in terms of the proportion of deaths is significant when compared to deaths from accidents. There is evidence of clustering where pilot suicides occur after by media reports of suicide or homicide-suicide. Five of six homicide-suicide events by pilots of commercial airliners occurred after they were left alone in the cockpit. This, along with a sixth incident in which active intervention by a Japan Air crew saved 147 lives, suggests that having two flight members in the cockpit is potentially protective. No single factor was associated with the risk for suicide or homicide-suicide. Factors associated with both events included legal and financial crises, occupational conflict, mental illness, and relationship stressors. Drugs and/or alcohol played a role in almost half of suicides, but not in homicide-suicides.

  15. Stakeholder involvement in the decommissioning of Dounreay

    International Nuclear Information System (INIS)

    Harrisson, Norman; LOVE, June; Murray, Marc

    2006-01-01

    The United Kingdom Atomic Energy Authority (UKAEA) was established in the 1950's to pioneer the development of nuclear energy within the UK. Today its primary mission is to decommission UK's former nuclear research sites and restore its environment in a way that is safe and secure, environmentally friendly, value for money and publicly Acceptable. UKAEA Dounreay celebrated its 50 birthday in 2005, having pioneered the development of fast reactor technology since 1955. Today the site is now leading the way in decommissioning. The Dounreay nuclear site licence covers an area of approximately 140 acres and includes 3 reactors: the Dounreay Material Test Reactor (DMTR), the Dounreay Fast Reactor (DFR), and the Prototype Fast Reactor (PFR). In addition there are 180 facilities on site which have supported the fast reactor programme, including a fuel reprocessing capability, laboratories and administration buildings. The reactors are now all in advanced stages of decommissioning. In October 2000 the Dounreay Site Restoration Plan (DSRP) was published to provide a framework for the site's restoration. The plan's objective was to reduce the site's hazards progressively by decontaminating and dismantling the plant, equipment and facilities, remediating contaminated ground and treating and packaging waste so it is suitable for long term storage or disposal. Whilst hailed as the most detailed plan integrating some 1500 activities and spanning 60 years it was criticised for having no stakeholder involvement. In response to this criticism, UKAEA developed a process for public participation over the following 2 years and launched its stakeholder engagement programme in October 2002. In order to provide a larger platform for the engagement process an advertisement was placed in the Scottish media inviting people to register as stakeholders in the Dounreay Site Restoration Plan. The stakeholder list now total over 1000. In October 2002 UKAEA launched their commitment to public

  16. Alzheimer Europe's position on involving people with dementia in research through PPI (patient and public involvement)

    DEFF Research Database (Denmark)

    Gove, Dianne; Diaz-Ponce, Ana; Georges, Jean

    2018-01-01

    This paper reflects Alzheimer Europe's position on PPI (patient and public involvement) in the context of dementia research and highlights some of the challenges and potential risks and benefits associated with such meaningful involvement. The paper was drafted by Alzheimer Europe in collaboration...... with members of INTERDEM and the European Working Group of People with Dementia. It has been formally adopted by the Board of Alzheimer Europe and endorsed by the Board of INTERDEM and by the JPND working group 'Dementia Outcome Measures - Charting New Territory'. Alzheimer Europe is keen to promote...

  17. [Pyodermatitis-pyostomatitis vegetans with nasal involvement].

    Science.gov (United States)

    Peuvrel, L; Barbarot, S; Gagey-Caron, V; Tessier, M-H; Cassagnau, E; Stalder, J-F

    2008-11-01

    Pyodermatitis-pyostomatitis vegetans (PPV) is a rare chronic disorder often associated with inflammatory bowel disease. We report an isolated case involving the oral, labial and nasal mucosa. A 28-year-old man, in good general condition, presented with a 2-year history of painless stomatitis. The physical examination revealed pustular and exophytic lesions of the jugal, gingival and palatine mucosa on an erythematous background, as well as some pustular and crusted lesions of the lower lip and nostrils. Histopathological analysis revealed epithelial hyperplasia and a suprabasal cleft with some signs of acantholysis and numerous neutrophils and eosinophils. Direct and indirect immunofluorescence assay was negative. There was no associated bowel disease. We concluded on a diagnosis of PPV of younger subjects. The lesions disappeared with oral corticosteroids but with steroid dependency. PPV is a rare dermatosis associated in more than 75% of cases with inflammatory bowel disease, usually ulcerative colitis. Lesions of the oral mucosa are a constant finding and are characterised by aseptic pustules on an erythematous background. Skin lesions are pustular and more or less exophytic. To our knowledge, there have been no reports to date of intranasal lesions of PPV.

  18. Romanian woman involvement in governance after 1990

    Directory of Open Access Journals (Sweden)

    Matei Elena

    2010-01-01

    Full Text Available This study highlights forms of gender inequality in post-communist Romania, generated by an unsustainable political algorithm which marginalizes women and fails to use their potential, both in politics and in formal and informal resistance, and maintains women's traditional duties as a type of environmental injustice. Having as a starting point the assertion that equality, as required by a democratic and developed country, plays a key role in society issues, the study analyses, using human geography pathway, a series of demographic data on Romanian women and attempts to explain the observed fluctuations, both at a national and regional level and correlates them with women's degree of representation in politics, governance. It aims and focuses at analyzing gender inequality through the women's participating in governance after 1990 and their overall effects and feedbacks on the society. The results show the paradox between the prevalence of female population both in number and as workforce and its unequal involvement in all governs of Romania's post-communist period and as a new EU member. The study also draws several priorities of women politics, to alleviate this type of injustice, which could help the future society development. .

  19. Radioactive contamination incidents involving protective clothing

    International Nuclear Information System (INIS)

    Reichelt, R.; Clay, M.; Eichorst, J.

    1996-10-01

    The study focuses on incidents at Department of Energy (DOE) facilities involving the migration of radioactive contaminants through protective clothing. The authors analyzed 68 occurrence reports for the following factors: (1) type of work; (2) working conditions; (3) type of anti-contamination (anti-C) material; (4) area of body or clothing contaminated; and (5) nature of spread of contamination. A majority of reports identified strenuous work activities such as maintenance, construction, or decontamination and decommissioning (D ampersand D) projects. The reports also indicated adverse working conditions that included hot and humid or cramped work environments. The type of anti-C clothing most often identified was cotton or water-resistant, disposable clothing. Most of the reports also indicated contaminants migrating through perspiration-soaked areas, typically in the knees and forearms. On the basis of their survey, the authors recommend the use of improved engineering controls and resilient, breathable, waterproof protective clothing for work in hot, humid, or damp areas where the possibility of prolonged contact with contamination cannot be easily avoided or controlled

  20. Filicide-suicide involving children with disabilities.

    Science.gov (United States)

    Coorg, Rohini; Tournay, Anne

    2013-06-01

    Filicide-suicide, or murder of a child by a parent followed by suicide, has an unknown incidence in both the general and disabled population. As there is no national database, the authors examined known associated factors and newspaper reports to characterize filicide-suicide victims and perpetrators involving children with disabilities. A newspaper search was conducted using LexisNexis and NewsBank: Access World News databases through the University of California, Irvine Library's Web site. Age, gender of child and parent, method used, and diagnoses of parent and child were recorded. Twenty-two news articles were found describing a total of 26 disabled children as victims of filicide-suicide between 1982 and 2010. Eighty-one percent of children killed were male, and 54% were autistic. Thirty percent of perpetrators had a reported mental illness. Male children or children with autism may be at risk for filicide-suicide, but accurate record keeping is needed to determine the incidence and risk factors and aid in its prevention in the disabled population.

  1. Neonatal gastrointestinal involvement and congenital cytomegalovirus

    Directory of Open Access Journals (Sweden)

    Alessandro Porta

    2016-11-01

    Full Text Available Cytomegalovirus (CMV is the most common cause of congenital viral infection, affecting 0.2 to 2.3% of all live births in developed countries. Very low birth weight and extremely low birth weight newborns are at higher risk of symptomatic CMV infection, most commonly secondary and acquired through breast milk. Gastrointestinal involvement is rare in acquired CMV infections, but it could be an important manifestation of postnatal infection in preterm infants admitted to neonatal intensive care units. Early onset of CMV gastrointestinal signs/symptoms is very rare. In a review of the literature it is described in 5 newborns in the first 24 hours of life, and 6 considering the onset in the first week of life. This review describes also a case report of congenital CMV in an immunocompetent newborn with onset of gastrointestinal signs immediately after birth: a possible association between viral infection and enteric manifestations was considered in the differential diagnosis. A review of the literature of the different case reports found has done, with description and comparison of the different patients and clinical presentations.

  2. Radioactive contamination incidents involving protective clothing

    Energy Technology Data Exchange (ETDEWEB)

    Reichelt, R.; Clay, M.; Eichorst, J.

    1996-10-01

    The study focuses on incidents at Department of Energy (DOE) facilities involving the migration of radioactive contaminants through protective clothing. The authors analyzed 68 occurrence reports for the following factors: (1) type of work; (2) working conditions; (3) type of anti-contamination (anti-C) material; (4) area of body or clothing contaminated; and (5) nature of spread of contamination. A majority of reports identified strenuous work activities such as maintenance, construction, or decontamination and decommissioning (D&D) projects. The reports also indicated adverse working conditions that included hot and humid or cramped work environments. The type of anti-C clothing most often identified was cotton or water-resistant, disposable clothing. Most of the reports also indicated contaminants migrating through perspiration-soaked areas, typically in the knees and forearms. On the basis of their survey, the authors recommend the use of improved engineering controls and resilient, breathable, waterproof protective clothing for work in hot, humid, or damp areas where the possibility of prolonged contact with contamination cannot be easily avoided or controlled.

  3. Husbands' involvement in abortion in Vietnam.

    Science.gov (United States)

    Johansson, A; Nga, N T; Huy, T Q; Dat, D D; Holmgren, K

    1998-12-01

    This study analyzes the involvement of men in abortion in Vietnam, where induced abortion is legal and abortion rates are among the highest in the world. Twenty men were interviewed in 1996 about the role they played in their wives' abortions and about their feelings and ethical views concerning the procedure. The results showed that both husbands and wives considered the husband to be the main decisionmaker regarding family size, which included the decision to have an abortion, but that, in fact, some women had undergone an abortion without consulting their husbands in advance. Parents and in-laws were usually not consulted; the couples thought they might object to the decision on moral grounds. Respondents' ethical perspectives on abortion are discussed. When faced with an unwanted pregnancy, the husbands adopted an ethics of care and responsibility toward family and children, although some felt that abortion was immoral. The study highlights the importance of understanding husbands' perspectives on their responsibilities and rights in reproductive decisionmaking and their ethical and other concerns related to abortion.

  4. Nitric oxide bioavailability dysfunction involves in atherosclerosis.

    Science.gov (United States)

    Chen, Jing-Yi; Ye, Zi-Xin; Wang, Xiu-Fen; Chang, Jian; Yang, Mei-Wen; Zhong, Hua-Hua; Hong, Fen-Fang; Yang, Shu-Long

    2018-01-01

    The pathological characteristics of atherosclerosis (AS) include lipid accumulation, fibrosis formation and atherosclerotic plaque produced in artery intima, which leads to vascular sclerosis, lumen stenosis and irritates the ischemic changes of corresponding organs. Endothelial dysfunction was closely associated with AS. Nitric oxide (NO) is a multifunctional signaling molecule involved in the maintenance of metabolic and cardiovascular homeostasis. NO is also a potent endogenous vasodilator and enters for the key processes that suppresses the formation vascular lesion even AS. NO bioavailability indicates the production and utilization of endothelial NO in organisms, its decrease is related to oxidative stress, lipid infiltration, the expressions of some inflammatory factors and the alteration of vascular tone, which plays an important role in endothelial dysfunction. The enhancement of arginase activity and the increase in asymmetric dimethylarginine and hyperhomocysteinemia levels all contribute to AS by intervening NO bioavailability in human beings. Diabetes mellitus, obesity, chronic kidney disease and smoking, etc., also participate in AS by influencing NO bioavailability and NO level. Here, we reviewed the relationship between NO bioavailability and AS according the newest literatures. Copyright © 2017. Published by Elsevier Masson SAS.

  5. Processes involved in solving mathematical problems

    Science.gov (United States)

    Shahrill, Masitah; Putri, Ratu Ilma Indra; Zulkardi, Prahmana, Rully Charitas Indra

    2018-04-01

    This study examines one of the instructional practices features utilized within the Year 8 mathematics lessons in Brunei Darussalam. The codes from the TIMSS 1999 Video Study were applied and strictly followed, and from the 183 mathematics problems recorded, there were 95 problems with a solution presented during the public segments of the video-recorded lesson sequences of the four sampled teachers. The analyses involved firstly, identifying the processes related to mathematical problem statements, and secondly, examining the different processes used in solving the mathematical problems for each problem publicly completed during the lessons. The findings revealed that for three of the teachers, their problem statements coded as `using procedures' ranged from 64% to 83%, while the remaining teacher had 40% of his problem statements coded as `making connections.' The processes used when solving the problems were mainly `using procedures', and none of the problems were coded as `giving results only'. Furthermore, all four teachers made use of making the relevant connections in solving the problems given to their respective students.

  6. STUDY OF CARDIAC INVOLVEMENT IN DIPHTHERIA

    Directory of Open Access Journals (Sweden)

    Bala Raju Gundam

    2016-07-01

    Full Text Available BACKGROUND Diphtheria still endemic in many developing countries and is responsible for high case fatality. Myocardial involvement is a serious complication of diphtheria and diphtheria myocarditis frequently complicated by arrhythmias causes sudden death if not managed properly. So, early and adequate administration of Anti-Diphtheritic Serum (ADS and frequent monitoring particularly 24 hrs. ECG monitoring is helpful to detect any serious cardiac arrhythmias. METHODS A prospective study on patients who were culture positive diagnosed on the basis of WHO definition were treated and analysed in respect to homographic details, immunisation strategy, and clinical features with particular attention to myocarditis. RESULTS In the study, common age group affected by diphtheria was 5 to 10 years. Incidence of myocarditis more in same age group. Out of 64 patients with myocarditis, 23 patients died. CONCLUSION Incidence of diphtheria has increased in the recent years. Commonly effected age group is 5 to 10 years and most of them are presented with asymptomatic myocarditis. Symptomatic diphtheritic myocarditis has high mortality rate even with aggressive management. Patient who presented with either LBBB alone are with combination of other conduction of abnormalities has high mortality rate.

  7. Severities of transportation accidents involving large packages

    Energy Technology Data Exchange (ETDEWEB)

    Dennis, A.W.; Foley, J.T. Jr.; Hartman, W.F.; Larson, D.W.

    1978-05-01

    The study was undertaken to define in a quantitative nonjudgmental technical manner the abnormal environments to which a large package (total weight over 2 tons) would be subjected as the result of a transportation accident. Because of this package weight, air shipment was not considered as a normal transportation mode and was not included in the study. The abnormal transportation environments for shipment by motor carrier and train were determined and quantified. In all cases the package was assumed to be transported on an open flat-bed truck or an open flat-bed railcar. In an earlier study, SLA-74-0001, the small-package environments were investigated. A third transportation study, related to the abnormal environment involving waterways transportation, is now under way at Sandia Laboratories and should complete the description of abnormal transportation environments. Five abnormal environments were defined and investigated, i.e., fire, impact, crush, immersion, and puncture. The primary interest of the study was directed toward the type of large package used to transport radioactive materials; however, the findings are not limited to this type of package but can be applied to a much larger class of material shipping containers.

  8. Uncertainties Involved in the Iopospheric Conductivity Estimation

    Directory of Open Access Journals (Sweden)

    Young-Sil Kwak

    2002-12-01

    Full Text Available Various uncertainties involved in ionospheric conductivity estimation utilizing the electron density profile obtained from the Sondrestrom incoherent scatter radar are examined. First, we compare the conductivity which is based on raw electron density and the one based on corrected electron density that takes into account the effects of the difference between the electron and ion temperatures and the Debye length. The corrected electron density yields higher Pedersen and Hall conductivities than the raw electron density does. Second, the dependence of collision frequency model on the conductivity estimation is examined. Below 110 km conductivity does not depend significantly on collision frequency models. Above 110 km, however, the collision models affect the conductivity estimation. Third, the influence of the electron and ion temperatures on the conductivity estimation is examined. Electron and ion temperatures carrying an error of about 10% do not seem to affect significantly the conductivity estimation. Fourth, also examined is the effect of the choice of the altitude range of integration in calculating the height-integrated conductivity, conductance. It has been demonstrated that the lower and upper boundaries of the integration are quite sensitive to the estimation of the Hall and Pedersen conductances, respectively.

  9. Evaluation of pemphigus cases involving oral mucosa.

    Science.gov (United States)

    Karagöz, Gizem; Bektaş-Kayhan, Kivanç; Ünür, Meral

    2014-09-01

    Pemphigus, defines a group of disorders in autoimmune etiology which could be life-threatening and clinical manifestations are mainly epithelial blistering affecting cutaneous and/or mucosal surfaces including oral mucosa. The aim of our study is to evaluate the clinical appearance of pemphigus with oral involvement by reported 15 pemphigus cases. This retrospective study of 15 cases of pemphigus obtained over a period of 7 years from 2006 to 2013 in Istanbul University, Dentistry Faculty, Oral Medicine and Surgery Department was designed. Age distribution of pemphigus was from 15 to 59 years with an average age of 41.3 years. Of the 15 patients, the male:female ratio was 1:2.75 (4 male, 11 female). The most common clinical various of pemphigus was pemphigus vulgaris, diagnosed in all patients. The buccal mucosa (34.3%) was the most commonly affected site followed by tongue (20%), gingiva (17.1%), palate (11.4%), lips (11.4%) and floor of mouth (5.7%). Our explanation of this conclusion, while speculative, is that socioeconomic situation related stress in males and hormonal changes like pregnancy and menostasis in females; systemic disease and using drugs; dental trauma and bruxism could be responsible for flare up in the disease.

  10. Coronary involvement in Churg-Strauss syndrome.

    Science.gov (United States)

    Dendramis, Gregory; Paleologo, Claudia; Piraino, Davide; Arrotti, Salvatore; Assennato, Pasquale

    2015-01-01

    Systemic autoimmune diseases are themselves a relevant and independent risk factor for atherosclerosis and coronary ectasia. We describe a case of a 58-year-old Caucasian man who was admitted to our department for unstable angina. History of asthma, paranasal sinus abnormality, and peripheral eosinophilia given a high suspicion of Churg-Strauss syndrome (CSS). Diagnosis was performed with 5 of the 6 American College of Rheumatology criteria. The knowledge that CSS is often associated with significant coronary artery involvement and the persistence of chest pain led us to performing immediately a coronary angiography. Coronary angiography showed diffuse ectasic lesions, chronic occlusion of left anterior descending artery with homocoronary collateral circulation from left circumflex artery and subocclusive stenosis in the proximal tract of posterior descending artery. The early recognition of CSS, an aggressive invasive diagnostic approach, and an early appropriate therapy are important to prevent the progressive and permanent cardiac damage in these patients. In the setting of a multidisciplinary approach, careful cardiac assessment is an essential step in CSS, even in mildly symptomatic patients. Copyright © 2015 Cardiological Society of India. Published by Elsevier B.V. All rights reserved.

  11. Radioactive contamination incidents involving protective clothing

    International Nuclear Information System (INIS)

    Reichelt, R.A.; Clay, M.E.; Eichorst, A.J.

    1998-01-01

    The study focuses on incidents at Department of Energy facilities involving the migration of radioactive contaminants through protective clothing. The authors analyzed 68 occurrence reports for the following factors: (1) type of work, (2) working conditions, (3) type of anti-contamination material; (4) area of body or clothing contaminated; and (5) nature of spread of contamination. A majority of reports identified strenuous work activities such as maintenance, construction, or decontamination and decommissioning projects. The reports also indicated adverse working conditions that included hot and humid or cramped work environments. The type of anti-contamination clothing most often identified was cotton or water-resistant disposable clothing. Most of the reports also indicated contaminants migrating through perspiration-soaked areas, typically in the knees and forearms. On the basis of their survey, the authors recommend the use of improved engineering controls and resilient, breathable, waterproof protective clothing for work in hot, humid, or damp areas where the possibility of prolonged contact with contamination cannot be easily avoided or controlled. 1 ref., 6 figs., 1 tab

  12. Stakeholder Involvement in Brazil. Appendix IX.4

    International Nuclear Information System (INIS)

    2016-01-01

    In response to public concerns about mining projects, mechanisms for stakeholder involvement in decisions concerning the licensing process of mining operations have been established. The most popular ones are the public hearings. The environmental regulatory body, Brazilian Institute of the Environment and Renewable Natural Resources (Instituto Brasileiro do Meio Ambiente e dos Recursos Naturais Renováveis, IBAMA), makes use of these events to inform the local community about impacts on the economic, physical and social issues caused by the operation of a mining project. However, by legislation, a uranium mining and processing plant is not regulated solely by the environmental regulator at the state and federal level. The Brazilian National Nuclear Energy Commission (Comissão Nacional de Energia Nuclear, CNEN) plays the key role as the nuclear regulatory body, and in many situations, it is perceived by local communities, where uranium mining projects are developed, as the main responsible party responding to regulatory issues regarding this type of operation. The situation gets even more complicated when it is seen that uranium mining and processing operations are state owned activities and the independency of the regulatory body (mainly the nuclear regulatory authority) is questioned, or at least put under scrutiny. It is not common for an ‘independent’ organization to be requested to provide regulatory oversight and this undermines the trust the communities may have on the regulatory process carried on regarding that specific operation

  13. DICOM involving XML path-tag

    Science.gov (United States)

    Zeng, Qiang; Yao, Zhihong; Liu, Lei

    2011-03-01

    Digital Imaging and Communications in Medicine (DICOM) is a standard for handling, storing, printing, and transmitting information in medical imaging. XML (Extensible Markup Language) is a set of rules for encoding documents in machine-readable form which has become more and more popular. The combination of these two is very necessary and promising. Using XML tags instead of numeric labels in DICOM files will effectively increase the readability and enhance the clear hierarchical structure of DICOM files. However, due to the fact that the XML tags rely heavily on the orders of the tags, the strong data dependency has a lot of influence on the flexibility of inserting and exchanging data. In order to improve the extensibility and sharing of DICOM files, this paper introduces XML Path-Tag to DICOM. When a DICOM file is converted to XML format, adding simple Path-Tag into the DICOM file in place of complex tags will keep the flexibility of a DICOM file while inserting data elements and give full play to the advantages of the structure and readability of an XML file. Our method can solve the weak readability problem of DICOM files and the tedious work of inserting data into an XML file. In addition, we set up a conversion engine that can transform among traditional DICOM files, XML-DCM and XML-DCM files involving XML Path-Tag efficiently.

  14. Gastrointestinal system involvement in systemic lupus erythematosus.

    Science.gov (United States)

    Li, Z; Xu, D; Wang, Z; Wang, Y; Zhang, S; Li, M; Zeng, X

    2017-10-01

    Systemic lupus erythematosus (SLE) is a multisystem disorder which can affect the gastrointestinal (GI) system. Although GI symptoms can manifest in 50% of patients with SLE, these have barely been reviewed due to difficulty in identifying different causes. This study aims to clarify clinical characteristics, diagnosis and treatment of the four major SLE-related GI system complications: protein-losing enteropathy (PLE), intestinal pseudo-obstruction (IPO), hepatic involvement and pancreatitis. It is a systematic review using MEDLINE and EMBASE databases and the major search terms were SLE, PLE, IPO, hepatitis and pancreatitis. A total of 125 articles were chosen for our study. SLE-related PLE was characterized by edema and hypoalbuminemia, with Technetium 99m labeled human albumin scintigraphy ( 99m Tc HAS) and alpha-1-antitrypsin fecal clearance test commonly used as diagnostic test. The most common site of protein leakage was the small intestine and the least common site was the stomach. More than half of SLE-related IPO patients had ureterohydronephrosis, and sometimes they manifested as interstitial cystitis and hepatobiliary dilatation. Lupus hepatitis and SLE accompanied by autoimmune hepatitis (SLE-AIH overlap) shared similar clinical manifestations but had different autoantibodies and histopathological features, and positive anti-ribosome P antibody highly indicated the diagnosis of lupus hepatitis. Lupus pancreatitis was usually accompanied by high SLE activity with a relatively high mortality rate. Early diagnosis and timely intervention were crucial, and administration of corticosteroids and immunosuppressants was effective for most of the patients.

  15. Severities of transportation accidents involving large packages

    International Nuclear Information System (INIS)

    Dennis, A.W.; Foley, J.T. Jr.; Hartman, W.F.; Larson, D.W.

    1978-05-01

    The study was undertaken to define in a quantitative nonjudgmental technical manner the abnormal environments to which a large package (total weight over 2 tons) would be subjected as the result of a transportation accident. Because of this package weight, air shipment was not considered as a normal transportation mode and was not included in the study. The abnormal transportation environments for shipment by motor carrier and train were determined and quantified. In all cases the package was assumed to be transported on an open flat-bed truck or an open flat-bed railcar. In an earlier study, SLA-74-0001, the small-package environments were investigated. A third transportation study, related to the abnormal environment involving waterways transportation, is now under way at Sandia Laboratories and should complete the description of abnormal transportation environments. Five abnormal environments were defined and investigated, i.e., fire, impact, crush, immersion, and puncture. The primary interest of the study was directed toward the type of large package used to transport radioactive materials; however, the findings are not limited to this type of package but can be applied to a much larger class of material shipping containers

  16. [Socioprofessional variables involved in mobbing in nursing].

    Science.gov (United States)

    Fornés-Vives, Joana; Martínez-Abascal Martínez, M Angeles; García-Banda García, Gloria

    2008-01-01

    To determine the type, frequency and cause of the most frequent hostile behaviors in a sample of nurses in the Balearic Islands and the socio-professional variables involved. We performed a cross-sectional descriptive study. The sample was composed of 464 members of the association of nurses of the Balearic Islands (392 women and 49 men). Age ranged from 25 to 65 years (mean: 35.11; SD: 9.62); 368 worked in public institutions and 71 in private centers. The instrument used was the Psychological Mobbing Questionnaire. A total of 17.2% of the nurses believed they had experienced mobbing at work (men: 22.4%; women: 14.5%). Significant differences were found according to age, but not according to institution. The most frequent hostile behavior was related to distortion of information, criticism of the purported victim, and lack of professional consideration. The perpetrators of mobbing were mainly, and very significantly, the bosses. According to these results, one in five nurses in the Balearic Islands has experienced mobbing in the workplace. However, because of the low response rate, caution should be exercised when generalizing these results. Nevertheless, health institutions should bear these findings in mind to ensure standards of behavior that do not jeopardize workers' health and dignity.

  17. Primary bone lymphoma with multiple vertebral involvement

    Directory of Open Access Journals (Sweden)

    Showkat Hussain Dar

    2013-01-01

    Full Text Available A 20-year-old student presented with 2 months history of fever and night sweats, 15 days history of low backache, progressive weakness of both limbs of 7 days duration, and urinary retention for last 24 h. Examination revealed a sensory level at D 10 dermatome and grade two power in both the lower limbs with absent reflexes. Examination of spine revealed a knuckle at T8 level, which was tender on palpation. MRI spine showed erosion of D11-12 and L1 in vertebral bodies with destruction of left pedicles, transverse processes and lamina, and a prominent psoas abscess. Post gadolinium study revealed ring-enhancing lesions in the D11-12 and L1 vertebrae as well as the dural sac. Fine needle aspiration cytology (FNAC and bone biopsy demonstrated a non-Hodgkin′s lymphoma (NHL, large cell high-grade of the spine (primary, which as per age is the youngest case of NHL ever reported in literature with multiple vertebral involvement.

  18. Identification and treatment of APS renal involvement.

    Science.gov (United States)

    Tektonidou, M G

    2014-10-01

    Renal involvement in antiphospholipid syndrome (APS), either primary or systemic lupus erythematosus (SLE)-related APS, includes renal artery stenosis or thrombosis, renal infarction, renal vein thrombosis and a small-vessel vaso-occlusive nephropathy defined as "antiphospholipid antibody (aPL)-associated nephropathy." aPL-associated nephropathy is characterized by acute lesions, thrombotic microangiopathy, and chronic lesions such as fibrous intimal hyperplasia, organizing thrombi with or without recanalization, fibrous occlusions of arteries or arterioles and focal cortical atrophy. Systemic hypertension, hematuria, proteinuria (ranging from mild to nephrotic level) and renal insufficiency represent the major clinical manifestations associated with aPL-associated nephropathy. Similar renal histologic and clinical characteristics have been described among all different groups of patients with positive aPL (primary APS, SLE-related APS, catastrophic APS and SLE/non-APS with positive aPL). In patients with aPL-associated nephropathy lesions in the absence of other causes associated with similar histological characteristics, aPL testing needs to be considered. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  19. Hyperphagia of hyperthyroidism: is neuropeptide Y involved?

    Science.gov (United States)

    Pétervári, Erika; Balaskó, Márta; Jech-Mihálffy, Andrea; Székely, Miklós

    2005-11-01

    The possible role of neuropeptide Y (NPY) was studied in rats with hypermetabolism and hyperphagia induced by thyroxine (50-100-200 microg/day s.c. for 3-4 weeks). Both metabolic rate and body temperature increased quickly with thyroxine treatment, while hyperphagia started to develop only after 2 weeks of treatment. The weight gain rate progressively decreased or stopped. The NPY-induced hyperphagia was not altered significantly during thyroxine treatment (in severe thyrotoxicosis it was rather suppressed); the fasting-induced hyperphagia was smaller than in controls following 1 week of treatment, and it became enhanced only after 3 weeks, when the deficit in body weight indicated a certain level of starvation already prior to the food deprivation. The NPY-antagonist D-Tyr27,36,D-Thr32-NPY27,36 suppressed this fasting-induced hyperphagia, suggesting that endogenous NPY is involved in this late phase. In conclusion, hyperthyroidism per se does not increase the NPY activity, instead the quickly developing hyperthermia may inhibit the NPY actions; NPY may, however, be activated by a concurrent hypermetabolism-induced starvation.

  20. Bacterial Extracellular Polysaccharides Involved in Biofilm Formation

    Directory of Open Access Journals (Sweden)

    Elena P. Ivanova

    2009-07-01

    Full Text Available Extracellular polymeric substances (EPS produced by microorganisms are a complex mixture of biopolymers primarily consisting of polysaccharides, as well as proteins, nucleic acids, lipids and humic substances. EPS make up the intercellular space of microbial aggregates and form the structure and architecture of the biofilm matrix. The key functions of EPS comprise the mediation of the initial attachment of cells to different substrata and protection against environmental stress and dehydration. The aim of this review is to present a summary of the current status of the research into the role of EPS in bacterial attachment followed by biofilm formation. The latter has a profound impact on an array of biomedical, biotechnology and industrial fields including pharmaceutical and surgical applications, food engineering, bioremediation and biohydrometallurgy. The diverse structural variations of EPS produced by bacteria of different taxonomic lineages, together with examples of biotechnological applications, are discussed. Finally, a range of novel techniques that can be used in studies involving biofilm-specific polysaccharides is discussed.

  1. Cranial involvement in sickle cell disease

    Energy Technology Data Exchange (ETDEWEB)

    Alkan, Ozlem, E-mail: yalinozlem@hotmail.com [Department of Radiology, Faculty of Medicine, Baskent University, Ankara (Turkey); Kizilkilic, Ebru, E-mail: ebru90@yahoo.com [Department of Hematology, Faculty of Medicine, Baskent University, Ankara (Turkey); Kizilkilic, Osman, E-mail: ebos90@hotmail.com [Department of Radiology, Faculty of Medicine, Baskent University, Ankara (Turkey); Yildirim, Tulin, E-mail: ytulin@hotmail.com [Department of Radiology, Faculty of Medicine, Baskent University, Ankara (Turkey); Karaca, Sibel, E-mail: sibelkaraca@hotmail.com [Department of Neurology, Faculty of Medicine, Baskent University, Ankara (Turkey); Yeral, Mahmut, E-mail: mahmutyeral@hotmail.com [Department of Hematology, Faculty of Medicine, Baskent University, Ankara (Turkey); Kasar, Mutlu, E-mail: mutlukasar@hotmail.com [Department of Hematology, Faculty of Medicine, Baskent University, Ankara (Turkey); Ozdogu, Hakan, E-mail: hakanozdogu@hotmail.com [Department of Hematology, Faculty of Medicine, Baskent University, Ankara (Turkey)

    2010-11-15

    Purpose: To evaluate cranial findings in patients with neurologically symptomatic sickle cell disease (SCD). Materials and methods: We studied 50 consecutive patients with SCD and neurologic symptoms. All patients underwent brain MR examinations: all 50 underwent classic MR imaging; 42, diffusion-weighted MR imaging; 10, MR angiography; four, MR venography; and three patients, digital subtraction angiography. Results: Of the 50 SCD patients, 19 (38%) had normal MR findings, and 31 (62%) showed abnormalities on brain MR images. Of the 50 patients, 16 (32%) had ischemic lesions; two (4%), subarachnoid hemorrhage; one (2%), moya-moya pattern; one (2%), posterior reversible encephalopathy; one (2%), dural venous sinus thrombosis; 12 (24%), low marrow signal intensity and thickness of the diploic space; 12 (24%), cerebral atrophy; and two (4%), osteomyelitis. Twenty-seven patients (54%) presented with headache, which was the most common clinical finding. Conclusions: The cranial involvement is one of the most devastating complications of SCD. Early and accurate diagnosis is important in the management of cranial complications of SCD.

  2. Genes involved in cell division in mycoplasmas

    Directory of Open Access Journals (Sweden)

    Frank Alarcón

    2007-01-01

    Full Text Available Bacterial cell division has been studied mainly in model systems such as Escherichia coli and Bacillus subtilis, where it is described as a complex process with the participation of a group of proteins which assemble into a multiprotein complex called the septal ring. Mycoplasmas are cell wall-less bacteria presenting a reduced genome. Thus, it was important to compare their genomes to analyze putative genes involved in cell division processes. The division and cell wall (dcw cluster, which in E. coli and B. subtilis is composed of 16 and 17 genes, respectively, is represented by only three to four genes in mycoplasmas. Even the most conserved protein, FtsZ, is not present in all mycoplasma genomes analyzed so far. A model for the FtsZ protein from Mycoplasma hyopneumoniae and Mycoplasma synoviae has been constructed. The conserved residues, essential for GTP/GDP binding, are present in FtsZ from both species. A strong conservation of hydrophobic amino acid patterns is observed, and is probably necessary for the structural stability of the protein when active. M. synoviae FtsZ presents an extended amino acid sequence at the C-terminal portion of the protein, which may participate in interactions with other still unknown proteins crucial for the cell division process.

  3. SWEDISH CRIME FICTION AS SOCIALLY INVOLVED LITERATURE

    Directory of Open Access Journals (Sweden)

    Monika Samsel-Chojnacka

    2011-01-01

    Full Text Available Swedish crime novel has been transforming for many years to become more socially involved. The ambition of many writers is not only to entertain the readers but also to participating in the social debate, criticizing the political and economical system, focusing on important issues such as violence against women, exploitation of working class by the privileged ruling class, the problems of a modern family and the situation of immigrants. Since the moment when in the mid 60’s two journalists Maj Sjöwall and Per Wahlöö decided to use popular literature to spread social matters many other Swedish writers have decided to follow their way. Some of them are journalists – like Liza Marklund, Börge Hellström and Anders Roslund or Stieg Larsson. Their novels as well as the ones written by Henning Mannkel on Kurt Wallander have become crucial evidence of changes of Swedish society in the past twenty years. Modern Swedish crime fiction illustrates the population in the model fashion that is the reason why it can become one of the interests of the sociology of literature.

  4. Consumer involvement profiles: An application of consumer involvement in mobile industry

    Directory of Open Access Journals (Sweden)

    Homa Rahbarian

    2014-04-01

    Full Text Available This paper investigates consumer involvement profile among people who intend to purchase mobile devises. The study considers the effects of various factors influencing on purchase intention including consumers’ personal characteristics such as age, gender, income as well as some external factors including advertisement. The study uses a questionnaire in Likert scale, originally developed by O’Cass (2000 [O’Cass, A. (2000. An assessment of consumers' product, purchase decision, advertising and consumption involvement in fashion clothing. Journal of Economic Psychology, 21, 545-576.]. The questionnaire has been distributed among 385 people, randomly who purchased mobile devices from a mall in city of Tehran, Iran. Using Pearson correlation test, the study has concluded that oral advertisement as well as consumer purchase involvement have positive and strong relationship with consumer’s purchase intention. In terms of age, people aged 20-30 maintained the highest purchase intention. In addition, in terms of gender, men had more purchase involvement than women did.

  5. A successful effort to involve stakeholders in a facility siting decision using LIPS with stakeholder involvement

    International Nuclear Information System (INIS)

    Merkhofer, L.; Conway, R.; Anderson, B.

    1995-01-01

    Local public opposition to federal bureaucratic decisions has resulted in public agencies rethinking the role of stakeholders in decision making. Efforts to include stakeholders directly in the decision-making process are on the increase. Unfortunately, many attempts to involve members of the public in decisions involving complex technical issues have failed. A key problem has been defining a meaningful role for the public in the process of arriving at a technical decision. This paper describes a successful effort by Sandia National Laboratories (SNL) in New Mexico to involve stakeholders in an important technical decision associated with its Environmental Restoration (ER) Project. The decision was where to locate a Corrective Action Management Unit (CAMU), a facility intended to consolidate and store wastes generated from the cleanup of hazardous waste sites. A formal priority setting process known as the Laboratory Integration Prioritization System (LIPS) was adapted to provide an approach for involving the public. Although rarely applied to stakeholder participation, the LIPS process proved surprisingly effective. It produced a consensus over a selected site and enhanced public trust and understanding of Project activities

  6. Public involvement in radioactive waste management decisions

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-04-01

    Current repository siting efforts focus on Yucca Mountain, Nevada, where DOE`s Office of Civilian Radioactive Waste Management (OCRWM) is conducting exploratory studies to determine if the site is suitable. The state of Nevada has resisted these efforts: it has denied permits, brought suit against DOE, and publicly denounced the federal government`s decision to study Yucca Mountain. The state`s opposition reflects public opinion in Nevada, and has considerably slowed DOE`s progress in studying the site. The Yucca Mountain controversy demonstrates the importance of understanding public attitudes and their potential influence as DOE develops a program to manage radioactive waste. The strength and nature of Nevada`s opposition -- its ability to thwart if not outright derail DOE`s activities -- indicate a need to develop alternative methods for making decisions that affect the public. This report analyzes public participation as a key component of this openness, one that provides a means of garnering acceptance of, or reducing public opposition to, DOE`s radioactive waste management activities, including facility siting and transportation. The first section, Public Perceptions: Attitudes, Trust, and Theory, reviews the risk-perception literature to identify how the public perceives the risks associated with radioactivity. DOE and the Public discusses DOE`s low level of credibility among the general public as the product, in part, of the department`s past actions. This section looks at the three components of the radioactive waste management program -- disposal, storage, and transportation -- and the different ways DOE has approached the problem of public confidence in each case. Midwestern Radioactive Waste Management Histories focuses on selected Midwestern facility-siting and transportation activities involving radioactive materials.

  7. Immune Responses Involved in Mycobacterium Tuberculosis Infection

    Directory of Open Access Journals (Sweden)

    Roghayeh Teimourpour

    2016-09-01

    Full Text Available Background and Objectives: Mycobacterium tuberculosis is the causative agent of tuberculosis (TB. Approximately one-third of the world's population is infected with M. tuberculosis. Despite the availability of drug and vaccine, it remains one of the leading causes of death in humans especially in developing countries. Epidemiological studies have indicated that only 10-30% of people exposed to tubercle bacillus are infected with M. tuberculosis, and at least 90% of the infected people finally do not acquire TB. The studies have indicated that the host efficient immune system has essential roles in the control of TB infection such that the highest rate of mortality and morbidity is seen in immunocompromised patients such as people infected with HIV. M. tuberculosis is an obligatory intracellular bacterium. It enters the body mainly through the respiratory tract and alveolar macrophages combat this pathogen most commonly. In addition to alveolar macrophages, various T-cell subpopulations need to be activated to overcome this bacterium's resistance to the host defense systems. CD4+ T cells, through production of several cytokines such as IFN-γ and TNF-α, and CD8+ T cells, through cytotoxic activities and induction of apoptosis in infected cells, play critical roles in inducing appropriate immune responses against M. tuberculosis. Although cell-mediated immunity is the cornerstone of host responses against TB and the recent studies have provided evidence for the importance of humoral and innate immune system in the control of TB, a profound understanding of the immune responses would provide a basis for development of new generations of vaccines and drugs. The present study addresses immune responses involved in M. tuberculosis infection.

  8. Joint involvement in Lö fgren's syndrome

    Directory of Open Access Journals (Sweden)

    O. N. Egorova

    2016-01-01

    Full Text Available Objective: to study the clinical, laboratory, and instrumental features of joint involvement in patients with Löfgren's syndrome.Patients and methods. Examinations were made in 125 patients, among whom there were 21 men and 104 women (male:female ratio, 1:5; mean age, 42±12 years (from 18 to 69 years, the referral diagnoses were erythema nodosum (EN, panniculitis or vasculitis.Results. All the patients complained of painful red indurations on the upper and lower extremities; there were also complaints of joint pain (83%, cough, weakness, hyperhidrosis, dyspnea, myalgia, and sore throat (55%, and subfebrile temperatures (50%. Arthralgias were noted in all the cases; 70% had arthritis that was observed manly in the ankle joints (62%. In all the patients, joint damage was concurrent with EN. Articular manifestations preceded EN in 35 (28% patients. Laboratory tests showed that the median erythrocyte sedimentation rate was 20 [14; 31] mm/hr and C-reactive protein (CRP was 10 [6; 21] mg/l. Elevated CRP levels were significantly more common in arthritis (p = 0.003 and nodular fusion (p=0.04 and directly related to the number of subcutaneous nodules (p=0.008; r=0.29. Chest computed tomography revealed intrathoracic lymphadenopathy in all the patients; ground glass lung tissue injury (Stage II was identified in 42% of cases. Joint damage did not depend on the X-ray stage of sarcoidosis. 54% of the patients took nonsteroidal anti-inflammatory drugs, 60% received hydroxychloroquine 600 mg/day, and 50% had glucocorticoids (GC 4–6 mg/day. 35% of the patients received combined therapy with GC and cyclophosphamide 200 mg/week or methotrexate 15 mg/week. Articular syndrome virtually completely regressed during a year. Arthralgias in the ankle persisted in a few (4% cases.

  9. Sclerosteosis involving the temporal bone: histopathologic aspects.

    Science.gov (United States)

    Nager, G T; Hamersma, H

    1986-01-01

    Sclerosteosis is a rare, potentially lethal, autosomal recessive, progressive craniotubular sclerosing bone dysplasia with characteristic facial and skeletal features. The temporal bone changes include a marked increase in overall size, extensive sclerosis, narrowing of the external auditory canal, and severe constriction of the internal auditory meatus, fallopian canal, eustachian tube, and middle ear cleft. Attenuation of the bony canals of the 9th, 10th, and 11th cranial nerves, reduction in size of the internal carotid artery, and severe obliteration of the sigmoid sinus and jugular bulb also occur. Loss of hearing, generally bilateral, is a frequent symptom. It often manifests in early childhood and initially is expressed as sound conduction impairment. Later, a sensorineural hearing loss and loss of vestibular nerve function often develop. Impairment of facial nerve function is another feature occasionally present at birth. In the beginning, a unilateral intermittent facial weakness may occur which eventually progresses to a bilateral permanent facial paresis. The histologic examination of the temporal bones from a patient with sclerosteosis explains the mechanisms involved in the progressive impairment of sound conduction and loss of cochlear, vestibular, and facial nerve function. There is a decrease of the arterial blood supply to the brain and an obstruction of the venous drainage from it. The histopathology reveals the obstacles to decompression of the middle ear cleft, ossicular chain, internal auditory and facial canals, and the risks, and in many instances the contraindications, to such procedures. On the other hand, decompression of the sigmoid sinus and jugular bulb should be considered as an additional life-saving procedure in conjunction with the prophylactic craniotomy recommended in all adult patients.

  10. Public involvement in radioactive waste management decisions

    International Nuclear Information System (INIS)

    1994-04-01

    Current repository siting efforts focus on Yucca Mountain, Nevada, where DOE's Office of Civilian Radioactive Waste Management (OCRWM) is conducting exploratory studies to determine if the site is suitable. The state of Nevada has resisted these efforts: it has denied permits, brought suit against DOE, and publicly denounced the federal government's decision to study Yucca Mountain. The state's opposition reflects public opinion in Nevada, and has considerably slowed DOE's progress in studying the site. The Yucca Mountain controversy demonstrates the importance of understanding public attitudes and their potential influence as DOE develops a program to manage radioactive waste. The strength and nature of Nevada's opposition -- its ability to thwart if not outright derail DOE's activities -- indicate a need to develop alternative methods for making decisions that affect the public. This report analyzes public participation as a key component of this openness, one that provides a means of garnering acceptance of, or reducing public opposition to, DOE's radioactive waste management activities, including facility siting and transportation. The first section, Public Perceptions: Attitudes, Trust, and Theory, reviews the risk-perception literature to identify how the public perceives the risks associated with radioactivity. DOE and the Public discusses DOE's low level of credibility among the general public as the product, in part, of the department's past actions. This section looks at the three components of the radioactive waste management program -- disposal, storage, and transportation -- and the different ways DOE has approached the problem of public confidence in each case. Midwestern Radioactive Waste Management Histories focuses on selected Midwestern facility-siting and transportation activities involving radioactive materials

  11. Evaluation of a Blog Based Parent Involvement Approach by Parents

    Science.gov (United States)

    Ozcinar, Zehra; Ekizoglu, Nihat

    2013-01-01

    Despite the well-known benefits of parent involvement in children's education, research clearly shows that it is difficult to effectively involve parents. This study aims to capture parents' views of a Blog Based Parent Involvement Approach (BPIA) designed to secure parent involvement in education by strengthening school-parent communication. Data…

  12. The Role of Father Involvement in Children's Later Mental Health.

    Science.gov (United States)

    Flouri, Eirini; Buchanan, Ann

    2003-01-01

    Explores links between father involvement at age 7 and emotional and behavioral problems at age 16, and between father involvement at age 16 and psychological distress at age 33. Father involvement at age 7 protected against psychological maladjustment in adolescents from non-intact families, and father involvement at age 16 protected against…

  13. Two Fatal Intoxications Involving Butyryl Fentanyl

    Science.gov (United States)

    Poklis, Justin; Poklis, Alphonse; Wolf, Carl; Hathaway, Cindie; Arbefeville, Elise; Chrostowski, Leszek; Devers, Kelly; Hair, Laura; Mainland, Mary; Merves, Michele; Pearson, Julia

    2016-01-01

    We present the case histories, autopsy findings and toxicology findings of two fatal intoxications involving the designer drug, butyryl fentanyl. The quantitative analysis of butyryl fentanyl in postmortem fluids and tissues was performed by an ultrahigh-performance liquid chromatography tandem mass spectrometry method. In the first case, butyryl fentanyl was the only drug detected with concentrations of 99 ng/mL in peripheral blood, 220 ng/mL in heart blood, 32 ng/mL in vitreous humor, 590 ng/mL in gastric contents, 93 ng/g in brain, 41 ng/g in liver, 260 ng/mL in bile and 64 ng/mL in urine. The cause of death was ruled fatal intoxication by butyryl fentanyl. In the second case, butyryl fentanyl was detected along with acetyl fentanyl, alprazolam and ethanol. The butyryl fentanyl concentrations were 3.7 ng/mL in peripheral blood, 9.2 ng/mL in heart blood, 9.8 ng/mL in vitreous humor, 4,000 ng/mL in gastric contents, 63 ng/g in brain, 39 ng/g in liver, 49 ng/mL in bile and 2 ng/mL in urine. The acetyl fentanyl concentrations were 21 ng/mL in peripheral blood, 95 ng/mL in heart blood, 68 ng/mL in vitreous humor, 28,000 ng/mL in gastric contents, 200 ng/g in brain, 160 ng/g in liver, 330 ng/mL in bile and 8 ng/mL in urine. In addition, the alprazolam concentration was 40 ng/mL and the ethanol concentration was 0.11 g/dL, both measured in peripheral blood. The cause of death in the second case was ruled a mixed drug intoxication. In both cases, the manner of death was accident. PMID:27339481

  14. Unilateral corneal leukoplakia without limbal involvement

    Directory of Open Access Journals (Sweden)

    Hirano K

    2015-05-01

    .0. Conclusion: Our case of unilateral corneal leukoplakia without limbal involvement was most likely caused by chronic irritation of the cornea by the eyelashes. Although it was totally removed with good recovery of vision, we continue to follow the patient because of the potential of malignant transformation. Keywords: corneal leukoplakia, hyperkeratosis, eyelashes, chronic friction

  15. KORELASI ANTARA EMPLOYEES INVOLVEMENT, TURNOVER SERTA PENGARUHNYA TERHADAP PRODUKTIVITAS

    Directory of Open Access Journals (Sweden)

    Purnawan Adi Wicaksono

    2012-02-01

    Full Text Available Praktek yang berkembang menyatakan bahwa employee involvement memiliki efek positif terhadap kinerja organisasi. Perubahan pada kultur organisasi dapat menimbulkan dampak berkurangnya absen, turnover, pengambilan keputusan yang lebih baik dan sebagainya. Sehingga menarik untuk diteliti apakah ada korelasi antara aplikasi perubahan organisasi yaitu employee involvement, turnover serta produktivitas Berdasarkan studi literatur didapatkan hubungan antara employee involvement dengan level turnover, serta hubungan turnover dengan produktivitas. Sehingga employee involvement dapat digunakan sebagai salah satu aspek menghitung produktivitas Keyword : employee involvement, turnover, produktivitas

  16. Early father's and mother's involvement and child's later educational outcomes.

    Science.gov (United States)

    Flouri, Eirini; Buchanan, Ann

    2004-06-01

    Few studies have investigated the individual long-term contributions that mothers and fathers make to their children's schooling. (1) To explore the role of early father involvement in children's later educational attainment independently of the role of early mother involvement and other confounds, (2) to investigate whether gender and family structure moderate the relationship between father's and mother's involvement and child's educational attainment, and (3) to explore whether the impact of father's involvement depends on the level of mother's involvement. The study used longitudinal data from the National Child Development Study. The initial sample were those 7,259 cohort members with valid data on mother involvement at age 7, father involvement at age 7, and school-leaving qualification by age 20. Of those, 3,303 were included in the final analysis. The measures were control variables, structural factors (family structure, sibship size and residential mobility), child factors (emotional/behavioural problems, cognitive ability and academic motivation), and father's and mother's involvement. Father involvement and mother involvement at age 7 independently predicted educational attainment by age 20. The association between parents' involvement and educational attainment was not stronger for sons than for daughters. Father involvement was not more important for educational attainment when mother involvement was low rather than high. Not growing up in intact two-parent family did not weaken the association between father's or mother's involvement and educational outcomes. Early father involvement can be another protective factor in counteracting risk conditions that might lead to later low attainment levels.

  17. Violence, victimization, criminal justice involvement, and substance use among drug-involved men.

    Science.gov (United States)

    Golder, Seana; Logan, T K

    2014-01-01

    This research identified three subgroups of drug-involved men based on severity of self-reported violence perpetration against intimate or nonintimate partners among a sample of 148 men selected from a subsample of participants in the Kentucky National Institute on Drug Abuse (NIDA) AIDS Cooperative Agreement. Men in the No Violence group accounted for approximately 19% of the total respondents, men in the Moderate Violence Severity and Extreme Violence Severity groups comprises 56% and 25% of the sample, respectively. Men in the Extreme Violence Severity group experienced significantly more psychological victimization as children and more frequent physical childhood abuse than did their peers. Men in the Extreme Violence Severity group reported having earlier involvement in the criminal justice system and lawbreaking behavior; they also reported higher frequency of marijuana and crack use. Implications for treatment and future research are presented.

  18. Job Satisfaction, Organizational Commitment and Job Involvement: The Mediating Role of Job Involvement.

    Science.gov (United States)

    Ćulibrk, Jelena; Delić, Milan; Mitrović, Slavica; Ćulibrk, Dubravko

    2018-01-01

    We conducted an empirical study aimed at identifying and quantifying the relationship between work characteristics, organizational commitment, job satisfaction, job involvement and organizational policies and procedures in the transition economy of Serbia, South Eastern Europe. The study, which included 566 persons, employed by 8 companies, revealed that existing models of work motivation need to be adapted to fit the empirical data, resulting in a revised research model elaborated in the paper. In the proposed model, job involvement partially mediates the effect of job satisfaction on organizational commitment. Job satisfaction in Serbia is affected by work characteristics but, contrary to many studies conducted in developed economies, organizational policies and procedures do not seem significantly affect employee satisfaction.

  19. Job Satisfaction, Organizational Commitment and Job Involvement: The Mediating Role of Job Involvement

    Science.gov (United States)

    Ćulibrk, Jelena; Delić, Milan; Mitrović, Slavica; Ćulibrk, Dubravko

    2018-01-01

    We conducted an empirical study aimed at identifying and quantifying the relationship between work characteristics, organizational commitment, job satisfaction, job involvement and organizational policies and procedures in the transition economy of Serbia, South Eastern Europe. The study, which included 566 persons, employed by 8 companies, revealed that existing models of work motivation need to be adapted to fit the empirical data, resulting in a revised research model elaborated in the paper. In the proposed model, job involvement partially mediates the effect of job satisfaction on organizational commitment. Job satisfaction in Serbia is affected by work characteristics but, contrary to many studies conducted in developed economies, organizational policies and procedures do not seem significantly affect employee satisfaction. PMID:29503623

  20. Consumer involvement profiles: An application of consumer involvement in mobile industry

    OpenAIRE

    Homa Rahbarian; Fattaneh Alizadeh Meshkani

    2014-01-01

    This paper investigates consumer involvement profile among people who intend to purchase mobile devises. The study considers the effects of various factors influencing on purchase intention including consumers’ personal characteristics such as age, gender, income as well as some external factors including advertisement. The study uses a questionnaire in Likert scale, originally developed by O’Cass (2000) [O’Cass, A. (2000). An assessment of consumers' product, purchase decision, advertising a...

  1. Involving South Asian patients in clinical trials.

    Science.gov (United States)

    Hussain-Gambles, M; Leese, B; Atkin, K; Brown, J; Mason, S; Tovey, P

    2004-10-01

    To investigate how South Asian patients conceptualise the notion of clinical trials and to identify key processes that impact on trial participation and the extent to which communication difficulties, perceptions of risk and attitudes to authority influence these decisions. Also to identify whether 'South Asian' patients are homogeneous in these issues, and which factors differ between different South Asian subgroups and finally how professionals regard the involvement of South Asian patients and their views on strategies to increase participation. A review of the literature on minority ethnic participation in clinical trials was followed by three qualitative interview studies. Interviews were taped and transcribed (and translated if required) and subjected to framework analysis. Face-to-face interviews were conducted with 25 health professionals; 60 South Asian lay people who had not taken part in a trial and 15 South Asian trial participants. Motivations for trial participation were identified as follows: to help society, to improve own health or that of family and friends, out of obligation to the doctor and to increase scientific knowledge. Deterrents were concerns about drug side-effects, busy lifestyles, language, previous bad experiences, mistrust and feelings of not belonging to British society. There was no evidence of antipathy amongst South Asians to the concept of clinical trials and, overall, the younger respondents were more knowledgeable than the older ones. Problems are more likely to be associated with service delivery. Lack of being approached was a common response. Lay-reported factors that might affect South Asian participation in clinical trials include age, language, social class, feeling of not belonging/mistrust, culture and religion. Awareness of clinical trials varied between each group. There are more similarities than differences in attitudes towards clinical trial participation between the South Asian and the general population

  2. Bioethical Principles of Biomedical Research Involving Animals

    Directory of Open Access Journals (Sweden)

    Bakir Mehić

    2011-08-01

    Full Text Available A major requirement both of national and international ethical codes for human experimentation, and of national legislation in many cases, is that new substances or devices should not be used for the first time on human beings unless previous tests on animals have provided a reasonable presumption of their safety. That is so called: Good Clinical Praxis (GCP. There are two international ethical codes intended principally for the guidance of countries or institutions that have not yet formulated their own ethical requirements for human experimentation: The Declaration of Helsinki of the World Medical Association and The Proposed International Guidelines for Biomedical Research Involving Human Subjects of the Council for International Organizations of Medical Sciences and the World Health Organization[1].Animal experimentation is fundamental to the biomedical sciences, not only for the advancement of specific vital processes, but also for the improvement of methods of prevention, diagnosis, and treatment of disease both in man and in animals. The use of animals is also indispensable for testing the potency and safety of biological substances used in human and veterinary medicine, as well as for determining the toxicity of the rapidly growing number of molecules that never existed before in nature and which may represent a hazard to health. This extensive exploitation by man of animals implies philosophical and moral problems that are not peculiar to their use for scientific purposes, and there are no objective ethical criteria by which to judge claims and counterclaims in such matters[2]. However, there is a consensus that „deliberate cruelty is repugnant”.While many countries have general laws or regulations imposing penalties for ill-treatment of animals, relatively few make specific provision for their use for scientific purposes. Because of differing legal systems and cultural backgrounds there are varying approaches to the use of

  3. psycho-social correlates of students' involvement in secret cults

    African Journals Online (AJOL)

    PROF EKWUEME

    as constituting general threat to peace in institutions of higher learning. (Fawole ... involvement in secret cults, and to investigate if peer group do influence students involvement in secret cults. .... be of benefit to students, teachers, parents,.

  4. Gift and sacrifice: parental involvement in Latino adolescents' education.

    Science.gov (United States)

    Ceballo, Rosario; Maurizi, Laura K; Suarez, Gloria A; Aretakis, Maria T

    2014-01-01

    Although myriad studies document the benefits of parental involvement in education on various indicators of children's academic performance, less research examines parental involvement among adolescents in low-income Latino families. Incorporating a multidimensional conceptualization of parental involvement, this study examined the relation between parental involvement and academic outcomes in a sample of 223 low-income, Latino adolescents. Results indicated that three types of parental involvement (gift/sacrifice, future discussions/academic socialization, and school involvement) had significant, positive associations with academic outcomes. Moreover, our results suggest that parents' stories about struggles with poverty and immigration are an important component of parental involvement, contributing to adolescents' desire to succeed academically and "give back" to parents. Additionally, our findings indicated that the positive relations between parental involvement and academic outcomes were stronger for immigrant youth and for those with higher endorsements of the Latino cultural value of respeto (respect).

  5. Knowledge, Perception and Level of Male Partner Involvement in ...

    African Journals Online (AJOL)

    AJRH Managing Editor

    establishing the level of male partner involvement and influence of couple knowledge and perception on male involvement in choice of ... access to care and provision of emotional and ..... although the male partners are key decision makers.

  6. The divided Electorate: Media Use and Political Involvement

    NARCIS (Netherlands)

    Aarts, Kees; Semetko, Holli A.; Semetko, H.

    2003-01-01

    Research examining media effects on political attitudes has put forth broadly conflicting explanations: media use diminishes knowledge and involvement and contributes to political cynicism and declining turnout; media use contributes to learning, political involvement, trust, efficacy, and

  7. Understanding the dynamics of parent involvement in schooling ...

    African Journals Online (AJOL)

    Understanding the dynamics of parent involvement in schooling within the poverty context. ... South African Journal of Education ... understand the realities and dynamics facing parents when attempting to be involved in their child\\'s schooling.

  8. Factors that Influence Male Involvement in Sexual and Reproductive ...

    African Journals Online (AJOL)

    Erah

    taken to involve men in reproductive health must therefore consider addressing these two factors. A review of the ... masculinity involve violence against women, alcohol consumption ..... the use of mass media and mobile phone technology.

  9. Export Marketing Involvement of African Small and Medium Size ...

    African Journals Online (AJOL)

    Export Marketing Involvement of African Small and Medium Size Enterprises: Tanzania's Fish Processing Industry. ... This study examined the Export marketing involvement of SMEs from the Least ... EMAIL FULL TEXT EMAIL FULL TEXT

  10. The relationship between cannabis involvement and suicidal thoughts and behaviors

    NARCIS (Netherlands)

    Delforterie, M.J.; Lynskey, M.T.; Huizink, A.C.; Creemers, H.E.; Grant, J.D.; Few, L.R.; Glowinski, A.L.; Statham, D.J.; Trull, T.J.; Bucholz, K.K.; Madden, P.A.F.; Martin, N.G.; Heath, A.C.; Agrawal, A.

    2015-01-01

    Background In the present study, we examined the relationship between cannabis involvement and suicidal ideation (SI), plan and attempt, differentiating the latter into planned and unplanned attempt, taking into account other substance involvement and psychopathology. Methods We used two

  11. A Low-involvement Choice Model for Consumer Panel Data

    OpenAIRE

    Brugha, Cathal; Turley, Darach

    1987-01-01

    The long overdue surge of interest in consumer behaviour texts in low-involvement purchasing has only begun to gather momemtum. It often takes the form of asking whether concepts usually associated with high-involvement purchasing can be applied, albeit in a modified form, to low-involvement purchasing. One such concept is evoked set, that is the range of brands deemed acceptable by a consumer in a particular product area. This has characteristically been associated with consumption involving...

  12. Parental Involvement in Children's Education : A Gendered Perspective

    OpenAIRE

    Stanikzai, Razia

    2013-01-01

    The importance of parental involvement as an enabling factor in children’s education is well evidenced. Teachers have a critical role in facilitating or hindering parents’ involvement in their children’s learning. The research project provides an analysis of what teachers view as parents’ role in their children’s education with an emphasis on gender-differentiated involvement. It also discusses the barriers to parents’ involvement as well as explores whether teachers understand the importance...

  13. Trust and Parents' Involvement in Schools of Choice

    Science.gov (United States)

    Strier, Michal; Katz, Hagai

    2016-01-01

    Education researchers and policymakers have been focusing for the last three decades on increasing parental involvement in schools. Their work focused on the positive effects that parental involvement has on varied aspects of school quality and functioning. In this study we examined "trust," a known predictor of parental involvement in…

  14. Arab Parents' Involvement in School Reform in Israel

    Science.gov (United States)

    Arar, Khalid; Abu-Asbah, Khaled; Nasra, Muhammed Abu

    2014-01-01

    Current research indicates that parental involvement positively influences children's academic success. This study investigates parental involvement in the Arab education system in Israel, highlighting involvement in the New Horizon reform. We interviewed school principals and parent committee chairpersons from 15 Arab schools. The study confirmed…

  15. Turkish Parents' Perceptions of Their Involvement in Schooling

    Science.gov (United States)

    Erdener, Mehmet Akif

    2013-01-01

    Parent involvement has an influence on children's educational engagement during the elementary years. The purpose of this study was to examine the perceptions of rural Turkish parents about their involvement in schooling with elementary school students based on Epstein's (1995) six types of parental involvement (parenting, communicating,…

  16. Parents' Perceptions of Their Involvement in Schooling

    Science.gov (United States)

    Erdener, Mehmet Akif; Knoeppel, Robert C.

    2018-01-01

    Parent involvement has an influence on children's educational engagement during the elementary years. The objective of this study was to examine the perceptions of rural Turkish parents about their involvement in schooling with elementary school students based on Epstein's (1995) six types of parental involvement (parenting, communicating,…

  17. Examining Understandings of Parent Involvement in Early Childhood Programs

    Science.gov (United States)

    Hilado, Aimee V.; Kallemeyn, Leanne; Phillips, Lauren

    2013-01-01

    The importance of parent involvement in children's development and learning is increasingly recognized in the research literature and in federal and state policies; however, no unified definition of parent involvement exists. This study examined different understandings and definitions of parent involvement in a sample of administrators of…

  18. Langerhans cell histiocytosis with involvement of the pons: case report

    Energy Technology Data Exchange (ETDEWEB)

    Vourtsi, A. [Xatzopoulou, Athens (Greece)]|[Department of Radiology, University of Athens Medical School, Athens (Greece); Papadopoulos, A.; Moulopoulos, L.A.; Vlahos, L. [Department of Radiology, University of Athens Medical School, Athens (Greece); Xenellis, J. [Department of Otorhinolaryngology, University of Athens Medical School, Athens (Greece)

    1998-03-01

    Central nervous system involvement is uncommon in Langerhans cell histiocytosis. The suprasellar region is more frequently affected. There have been few reports of involvement of the brain parenchyma shown on CT or MRI. We present a case of involvement of the pons, showing marked contrast enhancement on MRI. (orig.) With 2 figs., 17 refs.

  19. Langerhans cell histiocytosis with involvement of the pons: case report

    International Nuclear Information System (INIS)

    Vourtsi, A.; Papadopoulos, A.; Moulopoulos, L.A.; Vlahos, L.; Xenellis, J.

    1998-01-01

    Central nervous system involvement is uncommon in Langerhans cell histiocytosis. The suprasellar region is more frequently affected. There have been few reports of involvement of the brain parenchyma shown on CT or MRI. We present a case of involvement of the pons, showing marked contrast enhancement on MRI. (orig.)

  20. Adolescents' Perceptions of Their Fathers' Involvement: Significance to School Attitudes.

    Science.gov (United States)

    Flouri, Eirini; Buchanan, Ann; Bream, Victoria

    2002-01-01

    Based on data from 2,722 British adolescents, this study explores whether perceived father involvement can be associated with school attitudes. Multiple regression analysis showed that both father involvement and mother involvement contributed significantly and independently to positive school attitudes. Furthermore, the association between father…

  1. A typology of place attachment and activity involvement

    Science.gov (United States)

    Andrew J. Mowen; Alan R. Graefe; Randy J. Virden

    1998-01-01

    While previous research suggests that place attachment and activity involvement impact visitor perceptions, it has not examined the simultaneous effects of these affective constructs. This study develops a typology of both place attachment and activity involvement. It examines variations between attachment-involvement levels and visitor evaluations of quality. Results...

  2. Developing what customers really need : involving customers in innovations

    NARCIS (Netherlands)

    Weber, M.E.A.; Weggeman, M.C.D.P.; Aken, van J.E.

    2012-01-01

    Involving users in new product design and development is in itself not a new phenomenon. Academic research on the subject, however, is relatively new. Since this new millennium research on user involvement in innovations has multiplied, exhibiting that firms who actively involve users in their

  3. Gang Involvement and Membership among Homeless and Runaway Youth.

    Science.gov (United States)

    Yoder, Kevin A.; Whitbeck, Les B.; Hoyt, Dan R.

    2003-01-01

    Assessed the extent of gang involvement among homeless and runaway youth, comparing gang members, gang-involved youth (not members), and non-gang youth on several dimensions. Interview data indicated that 15.4 percent of the youth were gang members and 32.2 percent were involved in gangs. These youth reported more family problems and school…

  4. Insular Cortex Is Involved in Consolidation of Object Recognition Memory

    Science.gov (United States)

    Bermudez-Rattoni, Federico; Okuda, Shoki; Roozendaal, Benno; McGaugh, James L.

    2005-01-01

    Extensive evidence indicates that the insular cortex (IC), also termed gustatory cortex, is critically involved in conditioned taste aversion and taste recognition memory. Although most studies of the involvement of the IC in memory have investigated taste, there is some evidence that the IC is involved in memory that is not based on taste. In…

  5. Parental Childrearing Attitudes as Correlates of Father Involvement during Infancy

    Science.gov (United States)

    Gaertner, Bridget M.; Spinrad, Tracy L.; Eisenberg, Nancy; Greving, Karissa A.

    2007-01-01

    Using daily diary data to document involvement with infants at 6-8 months of age (n = 142) and 6 months later (n = 95), we examined relations between reported childrearing attitudes and resident fathers' relative (as compared to mothers') involvement with children. Fathers' authoritarian views related negatively to their relative involvement on…

  6. Extended Communication Efforts Involved with College Long-Distance Relationships

    Science.gov (United States)

    Firmin, Michael W.; Firmin, Ruth L.; Merical, Kaile Lorenzen

    2013-01-01

    The present phenomenological, qualitative research study involved in-depth interviews of all 16 female, sophomore students involved in respective distance relationships at a private, selective, comprehensive, Midwest university. Among other results found in the study, the present article focuses on communication dynamics involved with the…

  7. Teacher Training in Family Involvement: An Interpersonal Approach.

    Science.gov (United States)

    Coleman, Mick; Wallinga, Charlotte

    2000-01-01

    Discusses ways to develop family-school-community involvement, based on an early childhood teacher training course in family involvement. Discusses strategies for using Maslow's Hierarchy of Needs to facilitate family involvement interactions, and using student teachers' experiences for structuring reflective thought about family involvement…

  8. Aerial gamma ray and magnetic survey: Idaho Project, Nemo Detail Area, South Dakota. Final report

    International Nuclear Information System (INIS)

    1980-04-01

    During the month of August, 1979, EG and G geoMetrics collected 148 miles of high sensitivity airborne radiometric and magnetic data in western South Dakota. Data were collected on tranverse lines 1/4 mile apart and on two tie lines approximately 2 miles apart in one detail area within the Rapid City 1 0 x 2 0 sheet. All data were fully reduced and interpretated by geoMetrics and presented in two volumes. A relative dearth of geologic information seems to exist in this area. Paleozoic and Precambrian sedimentary, metamorphic, and igneous rocks appear to cover most of the region of study. Paleozoic rocks are primarily confined to the eastern side. A wide variety of Precambrian rocks are present as mapped. In addition to the standard data presentations and processing procedures, the data were examined for anomalous uranium valves and mappable geochemical subunits using the radiometric and magnetic data. Principal component analysis was performed on the radiometric data using standard deviation subunits defined by BFEC

  9. Not finding Nemo: limited reef-scale retention in a coral reef fish

    KAUST Repository

    Nanninga, Gerrit B.; Saenz Agudelo, Pablo; Zhan, Peng; Hoteit, Ibrahim; Berumen, Michael L.

    2015-01-01

    evidence of consistently high levels of self-recruitment and local retention at various spatial scales. These findings have, to a certain degree, created a paradigm shift toward the perception that large fractions of locally produced recruitment may

  10. Teuvincenone F Suppresses LPS-Induced Inflammation and NLRP3 Inflammasome Activation by Attenuating NEMO Ubiquitination

    OpenAIRE

    Xibao Zhao; Xibao Zhao; Debing Pu; Debing Pu; Zizhao Zhao; Huihui Zhu; Hongrui Li; Hongrui Li; Yaping Shen; Xingjie Zhang; Ruihan Zhang; Jianzhong Shen; Weilie Xiao; Weilie Xiao; Weilin Chen

    2017-01-01

    Inflammation causes many diseases that are serious threats to human health. However, the molecular mechanisms underlying regulation of inflammation and inflammasome activation are not fully understood which has delayed the discovery of new anti-inflammatory drugs of urgent clinic need. Here, we found that the natural compound Teuvincenone F, which was isolated and purified from the stems and leaves of Premna szemaoensis, could significantly inhibit lipopolysaccharide (LPS)–induced pro-inflamm...

  11. Teuvincenone F Suppresses LPS-Induced Inflammation and NLRP3 Inflammasome Activation by Attenuating NEMO Ubiquitination

    OpenAIRE

    Zhao, Xibao; Pu, Debing; Zhao, Zizhao; Zhu, Huihui; Li, Hongrui; Shen, Yaping; Zhang, Xingjie; Zhang, Ruihan; Shen, Jianzhong; Xiao, Weilie; Chen, Weilin

    2017-01-01

    Inflammation causes many diseases that are serious threats to human health. However, the molecular mechanisms underlying regulation of inflammation and inflammasome activation are not fully understood which has delayed the discovery of new anti-inflammatory drugs of urgent clinic need. Here, we found that the natural compound Teuvincenone F, which was isolated and purified from the stems and leaves of Premna szemaoensis, could significantly inhibit lipopolysaccharide (LPS)?induced pro-inflamm...

  12. Finding Difference: Nemo and Friends Opening the Door to Disability Theory

    Science.gov (United States)

    Preston, Daniel L.

    2010-01-01

    While middle school and high school students may have watched the Disney and Disney/Pixar films when they were younger, chances are they did not do so with a critical eye toward difference and disability, despite the fact that these films serve as excellent tools for teaching about difference. Recent estimates label 20% of the world's population…

  13. Not finding Nemo: limited reef-scale retention in a coral reef fish

    KAUST Repository

    Nanninga, Gerrit B.

    2015-02-03

    The spatial scale of larval dispersal is a key predictor of marine metapopulation dynamics and an important factor in the design of reserve networks. Over the past 15 yr, studies of larval dispersal in coral reef fishes have generated accumulating evidence of consistently high levels of self-recruitment and local retention at various spatial scales. These findings have, to a certain degree, created a paradigm shift toward the perception that large fractions of locally produced recruitment may be the rule rather than the exception. Here we examined the degree of localized settlement in an anemonefish, Amphiprion bicinctus, at a solitary coral reef in the central Red Sea by integrating estimates of self-recruitment obtained from genetic parentage analysis with predictions of local retention derived from a biophysical dispersal model parameterized with real-time physical forcing. Self-recruitment at the reef scale (c. 0.7 km2) was virtually absent during two consecutive January spawning events (1.4 % in 2012 and 0 % in 2013). Predicted levels of local retention at the reef scale varied temporally, but were comparatively low for both simulations (7 % in 2012 and 0 % in 2013). At the same time, the spatial scale of simulated dispersal was restricted to approximately 20 km from the source. Model predictions of reef-scale larval retention were highly dependent on biological parameters, underlining the need for further empirical validations of larval traits over a range of species. Overall, our findings present an urgent caution when assuming the potential for self-replenishment in small marine reserves.

  14. [Labor accidents involving the eyes: assessment of occupational risks involving nursing workers].

    Science.gov (United States)

    de Almeida, Cristiana Brasil; Pagliuca, Lorita Marlena Freitag; Leite, Ana Lourdes Almeida e Silva

    2005-01-01

    The study aimed at identifying nursing workers who were victims of eye accidents and the type of accident; describing the measures taken and proposing Health Education methods. A descriptive and exploratory study was carried out at a public maternity hospital from September 2002 to January 2003. Data were collected through direct observation of the environment and interviews with workers. Subjects were ten professionals (one nurse, two technicians and seven nursing auxiliaries) who were victims of work accidents involving the eye. The accidents were grouped according to the type of material that caused the trauma: chemical substances (4), medication (3), mechanical trauma (1), scalp (1) and urine (1). The results reveal that hospital workers are vulnerable to labor accidents because the environment presents biological, chemical and physical risks. An important step to prevent the occurrence of new accidents would be the prevention of human mistakes through permanent training and the use of protection glasses.

  15. Young, disadvantaged fathers' involvement with their infants: an ecological perspective.

    Science.gov (United States)

    Gavin, Loretta E; Black, Maureen M; Minor, Sherman; Abel, Yolanda; Papas, Mia A; Bentley, Margaret E

    2002-09-01

    To investigate fathers' involvement with their children using an ecological model, multiple respondents, and a comprehensive definition of fathers' involvement. The study's primary objectives were: (a) to describe the characteristics of fathers whose infants are born to low-income, urban, African-American adolescent mothers; (b) to describe the ways in which fathers are involved with their children; and (c) to identify factors associated with fathers' involvement. A total of 181 first-time mothers (aged parenting. Mothers provided the name of their infant's father; 109 (60%) of the fathers also agreed to participate. Baseline interviews of mothers, fathers, and grandmothers addressed demographic characteristics, relationships, and the father's involvement with his child. Three multivariate regression models were used to identify factors associated with paternal involvement, explaining 35% to 51% of the variability in father involvement. Regardless of the respondent (mother, father, or grandmother), paternal involvement was predicted most strongly by the quality of the parents' romantic relationship. The father's employment status, the maternal grandmother's education, and the father's relationship with the baby's maternal grandmother were also associated with paternal involvement. The study confirmed the value of an ecological perspective that uses multiple informants and a comprehensive definition of father involvement that includes multiple role functions. Efforts to increase paternal involvement should help young parents separate the father's relationship with their child from the romantic relationship between the mother and father, address the roles played by maternal grandmothers, and assist fathers to complete their education, and obtain and keep jobs.

  16. Patient involvement in mental health care: culture, communication and caution.

    Science.gov (United States)

    Tse, Samson; Tang, Jessica; Kan, Alice

    2015-02-01

    Patient or service user involvement in mental health services (MHS) is a hallmark of the recovery approach. In this viewpoint article, we review Tambuyzer et al. paper 'Patient involvement in mental health care: One size does not fit all' in order to express our opinion of their work. We also suggest specific actions that may enhance the implementation of patient involvement in MHS. We make three main points about Tambuyzer et al. model. First, the cultural dimension of patient involvement seems underemphasized in the model. Second, the model might be improved if the increasing role of communications technology in patient involvement is taken into consideration. Third, it is important to acknowledge that the process of patient involvement is not linear, and participation is not a homogeneous experience. We suggest that the model be expanded and that further work be carried out on the implementation of patient involvement in MHS. © 2012 John Wiley & Sons Ltd.

  17. Consumer involvement in dietary guideline development: opinions from European stakeholders.

    Science.gov (United States)

    Brown, Kerry A; Hermoso, Maria; Timotijevic, Lada; Barnett, Julie; Lillegaard, Inger Therese L; Řehůřková, Irena; Larrañaga, Ainhoa; Lončarević-Srmić, Azra; Andersen, Lene Frost; Ruprich, Jiří; Fernández-Celemín, Laura; Raats, Monique M

    2013-05-01

    The involvement of consumers in the development of dietary guidelines has been promoted by national and international bodies. Yet, few best practice guidelines have been established to assist with such involvement. Qualitative semi-structured interviews explored stakeholders' beliefs about consumer involvement in dietary guideline development. Interviews were conducted in six European countries: the Czech Republic, Germany, Norway, Serbia, Spain and the UK. Seventy-seven stakeholders were interviewed. Stakeholders were grouped as government, scientific advisory body, professional and academic, industry or non-government organisations. Response rate ranged from 45 % to 95 %. Thematic analysis was conducted with the assistance of NVivo qualitative software. Analysis identified two main themes: (i) type of consumer involvement and (ii) pros and cons of consumer involvement. Direct consumer involvement (e.g. consumer organisations) in the decision-making process was discussed as a facilitator to guideline communication towards the end of the process. Indirect consumer involvement (e.g. consumer research data) was considered at both the beginning and the end of the process. Cons to consumer involvement included the effect of vested interests on objectivity; consumer disinterest; and complications in terms of time, finance and technical understanding. Pros related to increased credibility and trust in the process. Stakeholders acknowledged benefits to consumer involvement during the development of dietary guidelines, but remained unclear on the advantage of direct contributions to the scientific content of guidelines. In the absence of established best practice, clarity on the type and reasons for consumer involvement would benefit all actors.

  18. Pattern of extranodal involvement in non hodgkin's lymphoma

    International Nuclear Information System (INIS)

    Bangash, M.H.; Hussain, I.; Zakaria, M.; Piracha, M.N.

    2014-01-01

    To study the anatomical and histomorphological pattern of extranodal non Hodgkins lymphoma (NHL). Study Design: Descriptive study Place and Duration of Study: The study was carried out at Oncology department Combined Military Hospital Rawalpindi during July 2012 to April 2013. Materials and Methods: All newly diagnosed patients of NHL with extranodal involvement were included in the study. They were categorized as primary extranodal or secondary extranodal lymphomas. Histological pattern and site of involvement were studied. Results: The male to female ratio was 2.2:1 (Male 31, Female 14), and the mean age was 48.16 years (SD=13.40). Primary extranodal involvement was seen in 55.6% of patients. Secondary extranodal involvement was seen in 44.4% of patients. Diffuse large B-cell lymphoma (DLBCL) was the most common type of NHL observed in both primary and secondary extranodal involvement. Gastrointestinal tract was the most common site for primary extranodal involvement and bone marrow was the most common site for secondary extranodal involvement. Conclusion: High frequency of primary extranodal involvement was noted in our study. DLBCL was the most common morphological type observed. Gastrointestinal tract and secondary bone marrow involvement were the most common anatomical sites for primary and secondary extranodal involvement respectively. (author)

  19. The Education Rights of Street-Involved Children

    Directory of Open Access Journals (Sweden)

    Sonja Grover

    2010-05-01

    Full Text Available This paper provides an overview of certain key aspects of the practical and legal situation of street-involved children globally. The inadequate protection of these children under both domestic and international law is addressed. The diversity of the population of street-involved children is considered as is the fact that this group is composed of both legally stateless and de facto stateless children. The relationship of street involvement to child labor, various health risks and victimization is discussed. The educational needs of older street-involved children are addressed including their right to participate in decision-making regarding aspects of educational service design and delivery. The overall objective of this paper is to encourage those who are involved in, or could impact upon educational policy to include street-involved children in their educational planning implementation and advocacy efforts.

  20. Consumer involvement in oral nutritional supplements purchasing behavior

    Directory of Open Access Journals (Sweden)

    Dwi Meilia Fitriyani

    2017-06-01

    Full Text Available The paper aimed to get insight of consumer involvement in purchasing behavior towards ONS (Oral Nutritional Supplements for children. By implementing an online survey with sample size of 100, the research investigated the factors (motivation and stimulus factor influencing consumer involvement and the causality between consumer involvement with the product knowledge as well as purchasing behavior. The research tool used was a 5-points Likert questionnaire in which respondents were asked to show their agreements about 40 items of 5 constructs. A partial least square - structural equation modeling by Smart-PLS software used to test the model. The results of this research also comes to conclusion that motivation and stimulus factor had significant affects on consumer involvement, consumer involvement had significant influence to product knowledge as well as ONS purchasing behavior, however product knowledge did not have significant affects on purchasing behavior. The results also showed that the product involvement has an important influence on consumers behavior.

  1. Professional involvement is associated with increased job satisfaction among dietitians.

    Science.gov (United States)

    Mortensen, Jenny K; Nyland, Nora K; Fullmer, Susan; Eggett, Dennis L

    2002-10-01

    This study explored a relationship between professional involvement and job satisfaction among dietitians. A random sample of 2,600 employed registered dietitians (RDs) received a 55-item questionnaire including a standardized measure of job satisfaction. The response rate was 67.3%; 50.8% were useable (n = 1,321). Ninety-two percent of RDs reported job satisfaction. The mean score was 68.8 +/- .28 (possible range: 18-90), with scores over 54 indicating job satisfaction. A positive relationship was found between job satisfaction and markers of professional involvement. Additionally, six characteristics related to professional involvement were: having had a mentor, being a mentor, self-assessed high professional involvement, full-time employment, high annual income, and increased hours worked per week. There was also a positive relationship between markers of professional involvement and employer support. We conclude that, overall, RDs are satisfied with their jobs and that greater professional involvement is related to greater job satisfaction.

  2. Treatment of periodontal abcess with Class II furcation involvement

    OpenAIRE

    Nur Rahmah; Arni Irawaty Djais

    2016-01-01

    Treatment of periodontal abscess with furcation involvement has its own challenges in achieving the success of periodontal treatment. Teeth with periodontal abscesses often indicate the presence of furcation involvement. Most periodontal abscess occurs in approximately 92.5% molar. Furcation involvement on tooth abscesses had a greater challenge to the success of periodontal therapy. A male patient aged 36 years came to the clinic with active periodontal disease. On examination, the teeth are...

  3. Langerhans cell histiocytosis involving central nervous system: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Moon, Won Jin; Park, Dong Woo; Lee, Seung Ro; Hahm, Chang Kok; Ju, Kyung Bin [Hanyang University College of Medicine, Seoul (Korea, Republic of); Kim, Sung Tae [Ulsan University College of Medicine, Seoul (Korea, Republic of)

    1997-01-01

    Langerhans cell histiocytosis(LCH) is a systemic disorder characterized by idiopathic proliferation of histiocytes in the reticuloendothelial system; CNS involvement outside the hypothalamus or pituitary gland is uncommon. We present a case of LCH involving the brainstem, cerebellum, and temporal lobes, and also showing hypothalamic involvement. The lesions were isointense or hypointense on T1WI and hyperintense on T2WI, and showed multifocal enhancing nodules on post-contrast CT and Gd-enhanced MRI.

  4. Consumer involvement in oral nutritional supplements purchasing behavior

    OpenAIRE

    Fitriyani, Dwi Meilia; Yuliati, Lilik Noor; Simanjuntak, Megawati

    2017-01-01

    The paper aimed to get insight of consumer involvement in purchasing behavior towards ONS (Oral Nutritional Supplements) for children. By implementing an online survey with sample size of 100, the research investigated the factors (motivation and stimulus factor) influencing consumer involvement and the causality between consumer involvement with the product knowledge as well as purchasing behavior. The research tool used was a 5-points Likert questionnaire in which respondents were asked to ...

  5. Parental Childrearing Attitudes as Correlates of Father Involvement During Infancy

    OpenAIRE

    Gaertner, Bridget M.; Spinrad, Tracy L.; Eisenberg, Nancy; Greving, Karissa A.

    2007-01-01

    Using daily diary data to document involvement with infants at 6 – 8 months of age (n = 142) and 6 months later (n = 95), we examined relations between reported childrearing attitudes and resident fathers' relative (as compared to mothers') involvement with children. Fathers' authoritarian views related negatively to their relative involvement on weekdays, and this relation held over time for caregiving and playing activities. Mothers' protective attitudes had concurrent negative associations...

  6. Ophaceous Gout Involving the Whole Spine: An Unusual Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Min Woo; Lee, Ji Hae; Cho, Woo Ho [Dept. of Radiology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul (Korea, Republic of)

    2012-02-15

    Gout is a relatively common, crystal deposition disease, in which monosodium urate crystals are deposited in joint and periarticular tissues of the extremities. Involvement of the spine is exceedingly rare. Most patients with spinal gout present with symptomatic spinal cord compression. Diffuse involvement of tophi deposition inside the spinal central canal has not been reported. We now present a case of chronic tophaceous gout with extensive spinal involvement that resulted in diffuse spinal cord compression and led to paraplegia.

  7. Ophaceous Gout Involving the Whole Spine: An Unusual Case Report

    International Nuclear Information System (INIS)

    Shin, Min Woo; Lee, Ji Hae; Cho, Woo Ho

    2012-01-01

    Gout is a relatively common, crystal deposition disease, in which monosodium urate crystals are deposited in joint and periarticular tissues of the extremities. Involvement of the spine is exceedingly rare. Most patients with spinal gout present with symptomatic spinal cord compression. Diffuse involvement of tophi deposition inside the spinal central canal has not been reported. We now present a case of chronic tophaceous gout with extensive spinal involvement that resulted in diffuse spinal cord compression and led to paraplegia.

  8. Safety Climate, Perceived Risk, and Involvement in Safety Management

    OpenAIRE

    Kouabenan , Dongo Rémi; Ngueutsa , Robert ,; Safiétou , Mbaye

    2015-01-01

    International audience; This article examines the relationship between safety climate, risk perception and involvement in safety management by first-line managers (FLM). Sixty-three FLMs from two French nuclear plants answered a questionnaire measuring perceived workplace safety climate, perceived risk, and involvement in safety management. We hypothesized that a positive perception of safety climate would promote substantial involvement in safety management, and that this effect would be str...

  9. Customer Segmentation by Factors Influencing Brand Loyalty and Customer Involvement

    OpenAIRE

    Tereza Vebrová; Kateřina Venclová; Stanislav Rojík

    2016-01-01

    Brand loyalty and customer involvement are two important concepts that help explain and understand a significant part of consumer shopping behavior. The aim of the present work is to identify factors influencing brand loyalty and customer involvement. A further aim is to consider subsequent segmentation of customers with respect to different degrees of brand loyalty and customer involvement. The research was focused on the field of Czech telecommunication services – mobile operators. Primary ...

  10. X-Ray semiotics of cranial involvement in endocrine diseases

    International Nuclear Information System (INIS)

    Spuzyak, M.I.; Kramnoj, I.E.; Belaya, L.M.; Tyazhelova, O.V.; Litvinenko, V.M.

    1992-01-01

    The incidence and type of X-ray semeiotics of the skull involvement were studied in 703 patients with endocrine diseases. Craniorgam analysis involved study of the thickness and structure of the vault bones, shape and size of the skull, status of the sutures, internal plate relief, changes of the base of the skull, of the sella turcica first of all, and facial bone. The characteristic X-ray symprom complexes of the involvement of the skull in some endocrine diseases were distinguished

  11. Fatal crashes involving large numbers of vehicles and weather.

    Science.gov (United States)

    Wang, Ying; Liang, Liming; Evans, Leonard

    2017-12-01

    Adverse weather has been recognized as a significant threat to traffic safety. However, relationships between fatal crashes involving large numbers of vehicles and weather are rarely studied according to the low occurrence of crashes involving large numbers of vehicles. By using all 1,513,792 fatal crashes in the Fatality Analysis Reporting System (FARS) data, 1975-2014, we successfully described these relationships. We found: (a) fatal crashes involving more than 35 vehicles are most likely to occur in snow or fog; (b) fatal crashes in rain are three times as likely to involve 10 or more vehicles as fatal crashes in good weather; (c) fatal crashes in snow [or fog] are 24 times [35 times] as likely to involve 10 or more vehicles as fatal crashes in good weather. If the example had used 20 vehicles, the risk ratios would be 6 for rain, 158 for snow, and 171 for fog. To reduce the risk of involvement in fatal crashes with large numbers of vehicles, drivers should slow down more than they currently do under adverse weather conditions. Driver deaths per fatal crash increase slowly with increasing numbers of involved vehicles when it is snowing or raining, but more steeply when clear or foggy. We conclude that in order to reduce risk of involvement in crashes involving large numbers of vehicles, drivers must reduce speed in fog, and in snow or rain, reduce speed by even more than they already do. Copyright © 2017 National Safety Council and Elsevier Ltd. All rights reserved.

  12. Partnering Research Involving Mentoring and Education (PRIME) in Prostate Cancer

    National Research Council Canada - National Science Library

    Price, Marva M

    2006-01-01

    Partnering Research Involving Mentoring and Education in Prostate Cancer (PRIME) is a partnership between two nursing schools, Duke University School of Nursing and North Carolina Central University (NCCU...

  13. Partnering Research Involving Mentoring and Education (PRIME) in Prostate Cancer

    National Research Council Canada - National Science Library

    Price, Marva M

    2008-01-01

    Partnering Research Involving Mentoring and Education in Prostate Cancer (PRIME) was a partnership between two nursing schools, Duke University School of Nursing and North Carolina Central University (NCCU...

  14. Veteran preferences for romantic partner involvement in depression treatment.

    Science.gov (United States)

    Hershenberg, Rachel; Mavandadi, Shahrzad; Klaus, Johanna R; Oslin, David W; Sayers, Steven L

    2014-01-01

    The objective was to examine Veterans' preferences for romantic partner involvement in depression treatment and patient characteristics that are associated with the likelihood of preferred involvement. One hundred seventy-nine Veterans who met criteria for major or minor depression reported if they wanted their partners to give them medication reminders, accompany them to appointments, and speak with their treatment provider. Greater depression severity and wanting a partner to be less critical and more encouraging were associated with greater preferences for involvement. Veterans may view their partners' involvement in depression treatment as one opportunity for partners to decrease blame or understand more about their problems. Published by Elsevier Inc.

  15. Twelfth cranial nerve involvement in Guillian Barre syndrome.

    Science.gov (United States)

    Nanda, Subrat Kumar; Jayalakshmi, Sita; Ruikar, Devashish; Surath, Mohandas

    2013-07-01

    Guillian Barre Syndrome (GBS) is associated with cranial nerve involvement. Commonest cranial nerves involved were the facial and bulbar (IXth and Xth). Involvement of twelfth cranial nerve is rare in GBS. We present a case of GBS in a thirteen years old boy who developed severe tongue weakness and wasting at two weeks after the onset of GBS. The wasting and weakness of tongue improved at three months of follow up. Brief review of the literature about XIIth cranial nerve involvement in GBS is discussed.

  16. Twelfth cranial nerve involvement in Guillian Barre syndrome

    OpenAIRE

    Subrat Kumar Nanda; Sita Jayalakshmi; Devashish Ruikar; Mohandas Surath

    2013-01-01

    Guillian Barre Syndrome (GBS) is associated with cranial nerve involvement. Commonest cranial nerves involved were the facial and bulbar (IXth and Xth). Involvement of twelfth cranial nerve is rare in GBS. We present a case of GBS in a thirteen years old boy who developed severe tongue weakness and wasting at two weeks after the onset of GBS. The wasting and weakness of tongue improved at three months of follow up. Brief review of the literature about XIIth cranial nerve involvement in GBS is...

  17. Twelfth cranial nerve involvement in Guillian Barre syndrome

    Directory of Open Access Journals (Sweden)

    Subrat Kumar Nanda

    2013-01-01

    Full Text Available Guillian Barre Syndrome (GBS is associated with cranial nerve involvement. Commonest cranial nerves involved were the facial and bulbar (IXth and Xth. Involvement of twelfth cranial nerve is rare in GBS. We present a case of GBS in a thirteen years old boy who developed severe tongue weakness and wasting at two weeks after the onset of GBS. The wasting and weakness of tongue improved at three months of follow up. Brief review of the literature about XIIth cranial nerve involvement in GBS is discussed.

  18. Partnering Research Involving Mentoring and Education (PRIME) in Prostate Cancer

    National Research Council Canada - National Science Library

    Price, Marva M

    2007-01-01

    Partnering Research Involving Mentoring and Education in Prostate Cancer (PRIME) is a partnership between two nursing schools, Duke University School of Nursing and North Carolina Central University (NCCU...

  19. 48 CFR 319.705-5 - Awards involving subcontracting plans.

    Science.gov (United States)

    2010-10-01

    ... SERVICES SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Subcontracting With Small Business, Small Disadvantaged Business, and Women-Owned Small Business Concerns 319.705-5 Awards involving subcontracting plans...

  20. Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation

    Science.gov (United States)

    Tokunaga, Fuminori; Nishimasu, Hiroshi; Ishitani, Ryuichiro; Goto, Eiji; Noguchi, Takuya; Mio, Kazuhiro; Kamei, Kiyoko; Ma, Averil; Iwai, Kazuhiro; Nureki, Osamu

    2012-01-01

    LUBAC (linear ubiquitin chain assembly complex) activates the canonical NF-κB pathway through linear polyubiquitination of NEMO (NF-κB essential modulator, also known as IKKγ) and RIP1. However, the regulatory mechanism of LUBAC-mediated NF-κB activation remains elusive. Here, we show that A20 suppresses LUBAC-mediated NF-κB activation by binding linear polyubiquitin via the C-terminal seventh zinc finger (ZF7), whereas CYLD suppresses it through deubiquitinase (DUB) activity. We determined the crystal structures of A20 ZF7 in complex with linear diubiquitin at 1.70–1.98 Å resolutions. The crystal structures revealed that A20 ZF7 simultaneously recognizes the Met1-linked proximal and distal ubiquitins, and that genetic mutations associated with B cell lymphomas map to the ubiquitin-binding sites. Our functional analysis indicated that the binding of A20 ZF7 to linear polyubiquitin contributes to the recruitment of A20 into a TNF receptor (TNFR) signalling complex containing LUBAC and IκB kinase (IKK), which results in NF-κB suppression. These findings provide new insight into the regulation of immune and inflammatory responses. PMID:23032187