WorldWideScience

Sample records for investigation site-specific work

  1. WAG 2 remedial investigation and site investigation site-specific work plan/health and safety checklist for the soil and sediment task

    International Nuclear Information System (INIS)

    Holt, V.L.; Burgoa, B.B.

    1993-12-01

    This document is a site-specific work plan/health and safety checklist (WP/HSC) for a task of the Waste Area Grouping 2 Remedial Investigation and Site Investigation (WAG 2 RI ampersand SI). Title 29 CFR Part 1910.120 requires that a health and safety program plan that includes site- and task-specific information be completed to ensure conformance with health- and safety-related requirements. To meet this requirement, the health and safety program plan for each WAG 2 RI ampersand SI field task must include (1) the general health and safety program plan for all WAG 2 RI ampersand SI field activities and (2) a WP/HSC for that particular field task. These two components, along with all applicable referenced procedures, must be kept together at the work site and distributed to field personnel as required. The general health and safety program plan is the Health and Safety Plan for the Remedial Investigation and Site Investigation of Waste Area Grouping 2 at the Oak Ridge National Laboratory, Oak Ridge, Tennessee (ORNL/ER-169). The WP/HSCs are being issued as supplements to ORNL/ER-169

  2. WAG 2 remedial investigation and site investigation site-specific work plan/health and safety checklist for the sediment transport modeling task

    International Nuclear Information System (INIS)

    Holt, V.L.; Baron, L.A.

    1994-05-01

    This site-specific Work Plan/Health and Safety Checklist (WP/HSC) is a supplement to the general health and safety plan (HASP) for Waste Area Grouping (WAG) 2 remedial investigation and site investigation (WAG 2 RI ampersand SI) activities [Health and Safety Plan for the Remedial Investigation and Site Investigation of Waste Area Grouping 2 at the Oak Ridge National Laboratory, Oak Ridge, Tennessee (ORNL/ER-169)] and provides specific details and requirements for the WAG 2 RI ampersand SI Sediment Transport Modeling Task. This WP/HSC identifies specific site operations, site hazards, and any recommendations by Oak Ridge National Laboratory (ORNL) health and safety organizations [i.e., Industrial Hygiene (IH), Health Physics (HP), and/or Industrial Safety] that would contribute to the safe completion of the WAG 2 RI ampersand SI. Together, the general HASP for the WAG 2 RI ampersand SI (ORNL/ER-169) and the completed site-specific WP/HSC meet the health and safety planning requirements specified by 29 CFR 1910.120 and the ORNL Hazardous Waste Operations and Emergency Response (HAZWOPER) Program Manual. In addition to the health and safety information provided in the general HASP for the WAG 2 RI ampersand SI, details concerning the site-specific task are elaborated in this site-specific WP/HSC, and both documents, as well as all pertinent procedures referenced therein, will be reviewed by all field personnel prior to beginning operations

  3. WAG 2 remedial investigation and site investigation site-specific work plan/health and safety checklist for the ecological assessment task, Kingfisher Study

    International Nuclear Information System (INIS)

    Holt, V.L.; Baron, L.A.

    1994-05-01

    This report provides specific details and requirements for the WAG 2 remedial investigation and site investigation Ecological Assessment Task, Kingfisher Study, including information that will contribute to safe completion of the project. The report includes historical background; a site map; project organization; task descriptions and hazard evaluations; controls; and monitoring, personal protective equipment, decontamination, and medical surveillance program requirements. The report also includes descriptions of site personnel and their certifications as well as suspected WAG 2 contaminants and their characteristics. The primary objective of the WAG 2 Kingfisher Study is to assess the feasibility of using kingfishers as biological monitors of contaminants on the Oak Ridge Reservation (ORR). Kingfisher sample collection will be used to determine the levels of contaminants and degree of bioaccumulation within a common piscivorous bird feeding on contaminated fish from streams on the ORR

  4. Final work plan : environmental site investigation at Sylvan Grove, Kansas.

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, L. M. (Environmental Science Division)

    2012-07-15

    In 1998, carbon tetrachloride was found above the maximum contaminant level (MCL) of 5 {micro}g/L in groundwater from one private livestock well at Sylvan Grove, Kansas, by the Kansas Department of Health and Environment (KDHE). The 1998 KDHE sampling was conducted under the U.S. Department of Agriculture (USDA) private well sampling program. The Commodity Credit Corporation (CCC), a USDA agency, operated a grain storage facility in Sylvan Grove from 1954 to1966. Carbon tetrachloride is the contaminant of primary concern at sites associated with former CCC/USDA grain storage operations. Sylvan Grove is located in western Lincoln County, approximately 60 mi west of Salina (Figure 1.1). To determine whether the former CCC/USDA facility at Sylvan Grove is a potential contaminant source and its possible relationship to the contamination in groundwater, the CCC/USDA has agreed to conduct an investigation, in accordance with the Intergovernmental Agreement between the KDHE and the Farm Service Agency (FSA) of the USDA. This Work Plan presents historical data related to previous investigations, grain storage operations, local private wells and public water supply (PWS) wells, and local geologic and hydrogeologic conditions at Sylvan Grove. The findings from a review of all available documents are discussed in Section 2. On the basis of the analyses of historical data, the following specific technical objectives are proposed for the site investigation at Sylvan Grove: (1) Evaluate the potential source of carbon tetrachloride at the former CCC/USDA facility; (2) Determine the relationship of potential contamination (if present) at the former CCC/USDA facility to contamination identified in 1998 in groundwater samples from one private well to the west; and (3) Delineate the extent of potential contamination associated with the former CCC/USDA facility. The detailed scope of work is outlined in Section 3. The results of the proposed work will provide the basis for determining

  5. Summary report of the experiences from TVO's site investigations

    International Nuclear Information System (INIS)

    Oehberg, A.; Saksa, P.; Ahokas, H.; Ruotsalainen, P.; Snellman, M.

    1994-09-01

    In 1992 Teollisuuden Voima Oy (TVO) completed preliminary site investigations for radioactive waste disposal at five sites in Finland. The aim of this report was the compilation of the experiences from TVO's site investigations. The main interest was focused on investigation strategies and the most important investigation methods for the conceptual modelling. The objective of the preliminary site investigations was to obtain data on the bedrock properties in order to evaluate the areas. The programme was divided into four stages, each stage having its own subobjective. The site-specific investigation programme for each site included a large common part and a small site-specific part. The strategies (objectives) and experiences from different disciplines, geology, hydrogeochemistry, geophysics and geohydrology, are presented in the report. The conceptual modelling work procedure including both bedrock and groundwater modelling is described briefly using the Olkiluoto site as an example. Each of the other areas has undergone similar phases of work. (52 refs., 45 figs., 5 tabs.)

  6. Summary report of the experiences from TVO's site investigations

    International Nuclear Information System (INIS)

    Oehberg, A.; Saksa, P.; Ahokas, H.; Ruotsalainen, P.; Snellman, M.

    1994-05-01

    Teollisuuden Voima Oy (TVO) has completed preliminary site investigations at five sites in Finland. At the end of 1992 TVO presented the final report to the authorities. The preliminary site investigation phase 1986-1992 was conducted according to the investigation programme compiled by TVO. The aim of this report was to compile a report on experiences from TVOs site investigations. The main interest was focused on investigation strategies and the most important investigation methods for the conceptual modelling. The objective of the preliminary site investigations was to obtain data on the bedrock properties in order to evaluate the areas. The programme was divided into four stages, each stage having its own sub-objective. The site-specific investigation programme for each site included a large common part and a small site-specific part. The strategies (objectives) and experiences from different disciplines, geology, hydrogeochemistry, geophysics and geohydrology, are presented in the report. The conceptual modelling work procedure including both bedrock and groundwater modelling is described briefly using the Olkiluoto site as an example. Each of the other areas has undergone similar phases of work. The uncertainties associated with conceptual modelling are also discussed. The usefulness of the investigation strategy and the investigation methods for conceptual modelling is discussed in the report. Some new equipment, methods or enhancements that have not yet been used in TVOs site investigations have become new tools in site characterisation and are briefly presented in the report. 52 refs, 35 figs, 1 tab

  7. Site investigations. Investigation methods and general execution programme

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-01-01

    SKB plans to commence site investigations in 2002. The present report is a broadening of the general programme and describes the execution of the investigations in so-called discipline-specific programmes for the disciplines geology, rock mechanics, thermal properties, hydrogeology, hydro geochemistry, transport properties of the rock and surface ecosystems. It also describes various technical aspects of drilling, which comprises a significant portion of the investigations. Based on this possible programme, site-specific programmes will then be prepared and adapted to the site-specific questions and conditions on the specific candidate area. The main product of the investigations is a site description. This document presents an integrated description of the site (geosphere and biosphere) and its regional environs with respect to current state and naturally ongoing processes. Provided that the initial site investigation shows that the site is still favourable, complete investigations are commenced. Primary investigation data are stored in SKB's database SICADA. The database's primary data mainly represent parameter values for single measurement points or limited measurement objects. Primary data are subjected to both discipline-specific and integrated analysis and interpretation in order to be able to subdivide the site into suitable geometric units and to assign discipline-specific properties to these geometric units. In this way a three-dimensional, primarily geo scientific, site-descriptive model of rock and ground is built. The site-descriptive model is represented with the aid of both geographic information systems (GIS) and above all SKB's CAD-based computer tool, Rock Visualization System (RVS). RVS is also used as an active instrument in the interpretation of information, especially to be able to judge the relative locations of different deformation zones. When the site has been selected, the investigations are focused on characterizing

  8. International workshop on site investigation and evaluation based on the siting process in Sweden

    International Nuclear Information System (INIS)

    Andersson, Johan; Stroem, A.

    2001-06-01

    SKB's goal is to commence surface based site investigations in 2002. Extensive preparations are now being made for this transition to the next phase in the siting process for the deep repository for spent nuclear fuel. The purpose of the international workshop on site characterisation held at Aespoe April 2001 was to: present the SKB site investigation and evaluation programme to a group of international experts; discuss whether the available toolbox of investigation methods for surface based site investigations is appropriate and state-of-the-art in an international perspective; and by working group sessions discuss the level of ambition in the programme for site investigation for each discipline. This report summarises the conclusions of the workshop in general terms. Many of the detailed comments and ideas obtained at the workshop have already inspired and will also directly inspire the on-going planning work for site characterisation. The core activity at the workshop was the work performed by working groups. They addressed what should be considered for a site characterisation programme, based on the generic planning made so far by SKB. The working groups also outlined site specific characterisation programmes for the sites suggested by SKB. The tasks were strictly confined to technical and scientific modelling issues. The working group chairmen presented the working group results at the workshop and have also submitted short memos to SKB. The present document is a compilation of these memos. The SKB generic programme as presented in the existing top level documents, 'Requirements and Criteria and Overall Programme', received general endorsement and was appreciated for being comprehensive and systematic. For example, it contains comprehensive lists of parameters to be measured. However, there is need for prioritisation and sequencing. This is actually included in the current planning process at SKB where the generic programme later this year will be adapted to

  9. SITE-94. Site specific base data for the performance assessment

    International Nuclear Information System (INIS)

    Geier, J.; Tiren, S.; Dverstorp, B.; Glynn, P.

    1996-06-01

    This report documents the site specific base data that were available, and the utilization of these data within SITE-94. A brief summary is given of SKB's preliminary site investigations for the Aespoe Hard Rock Laboratory (HRL), which were the main source of site-specific data for SITE-94, and an overview is given of the field methods and instrumentation for the preliminary investigations. A compilation is given of comments concerning the availability and quality of the data for Aespoe, and specific recommendations are given for future site investigations. It was found that the HRL pre-investigations produced a large quantity of data which were, for the most part, of sufficient quality to be valuable for a performance assessment. However, some problems were encountered regarding documentation, procedural consistency, positional information, and storage of the data from the measurements. 77 refs, 4 tabs

  10. Site investigations. Investigation methods and general execution programme

    International Nuclear Information System (INIS)

    2001-01-01

    SKB plans to commence site investigations in 2002. The present report is a broadening of the general programme and describes the execution of the investigations in so-called discipline-specific programmes for the disciplines geology, rock mechanics, thermal properties, hydrogeology, hydro geochemistry, transport properties of the rock and surface ecosystems. It also describes various technical aspects of drilling, which comprises a significant portion of the investigations. Based on this possible programme, site-specific programmes will then be prepared and adapted to the site-specific questions and conditions on the specific candidate area. The main product of the investigations is a site description. This document presents an integrated description of the site (geosphere and biosphere) and its regional environs with respect to current state and naturally ongoing processes. Provided that the initial site investigation shows that the site is still favourable, complete investigations are commenced. Primary investigation data are stored in SKB's database SICADA. The database's primary data mainly represent parameter values for single measurement points or limited measurement objects. Primary data are subjected to both discipline-specific and integrated analysis and interpretation in order to be able to subdivide the site into suitable geometric units and to assign discipline-specific properties to these geometric units. In this way a three-dimensional, primarily geo scientific, site-descriptive model of rock and ground is built. The site-descriptive model is represented with the aid of both geographic information systems (GIS) and above all SKB's CAD-based computer tool, Rock Visualization System (RVS). RVS is also used as an active instrument in the interpretation of information, especially to be able to judge the relative locations of different deformation zones. When the site has been selected, the investigations are focused on characterizing conditions at depth

  11. DbPTM 3.0: an informative resource for investigating substrate site specificity and functional association of protein post-translational modifications.

    Science.gov (United States)

    Lu, Cheng-Tsung; Huang, Kai-Yao; Su, Min-Gang; Lee, Tzong-Yi; Bretaña, Neil Arvin; Chang, Wen-Chi; Chen, Yi-Ju; Chen, Yu-Ju; Huang, Hsien-Da

    2013-01-01

    Protein modification is an extremely important post-translational regulation that adjusts the physical and chemical properties, conformation, stability and activity of a protein; thus altering protein function. Due to the high throughput of mass spectrometry (MS)-based methods in identifying site-specific post-translational modifications (PTMs), dbPTM (http://dbPTM.mbc.nctu.edu.tw/) is updated to integrate experimental PTMs obtained from public resources as well as manually curated MS/MS peptides associated with PTMs from research articles. Version 3.0 of dbPTM aims to be an informative resource for investigating the substrate specificity of PTM sites and functional association of PTMs between substrates and their interacting proteins. In order to investigate the substrate specificity for modification sites, a newly developed statistical method has been applied to identify the significant substrate motifs for each type of PTMs containing sufficient experimental data. According to the data statistics in dbPTM, >60% of PTM sites are located in the functional domains of proteins. It is known that most PTMs can create binding sites for specific protein-interaction domains that work together for cellular function. Thus, this update integrates protein-protein interaction and domain-domain interaction to determine the functional association of PTM sites located in protein-interacting domains. Additionally, the information of structural topologies on transmembrane (TM) proteins is integrated in dbPTM in order to delineate the structural correlation between the reported PTM sites and TM topologies. To facilitate the investigation of PTMs on TM proteins, the PTM substrate sites and the structural topology are graphically represented. Also, literature information related to PTMs, orthologous conservations and substrate motifs of PTMs are also provided in the resource. Finally, this version features an improved web interface to facilitate convenient access to the resource.

  12. Site-specific investigations of aquifer thermal energy storage for space and process cooling

    International Nuclear Information System (INIS)

    Brown, D.R.

    1991-01-01

    This paper reports on the Pacific Northwest Laboratory (PNL) that has completed three preliminary site-specific feasibility studies that investigated aquifer thermal energy storage (ATES) for reducing space and process cooling costs. Chilled water stored in an ATES system could be used to meet all or part of the process and/or space cooling loads at the three facilities investigated. Seasonal or diurnal chill ATES systems could be significantly less expensive than a conventional electrically-driven, load-following chiller system at one of the three sites, depending on the cooling water loop return temperature and presumed future electricity escalation rate. For the other two sites investigated, a chill ATES system would be economically competitive with conventional chillers if onsite aquifer characteristics were improved. Well flow rates at one of the sites were adequate, but the expected thermal recovery efficiency was too low. The reverse of this situation was found at the other site, where the thermal recovery efficiency was expected to be adequate, but well flow rates were too low

  13. Final Work Plan: Targeted Investigation at York, Nebraska

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, Lorraine M. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2016-08-01

    The targeted investigation at York will be implemented in phases, so that data collected and interpretations developed at each stage of the program can be evaluated to guide subsequent phases most effectively. Section 2 of this Work Plan presents a brief overview of the York site, its geologic and hydrologic setting, and the previous CCC/USDA investigations. Section 3, outlines the proposed technical program for the targeted investigation, and Section 4 describes the investigative methods to be employed. A community relations plan is in Section 5, and Section 6 includes health and safety information. In addition to this site-specific Work Plan, the Master Work Plan (Argonne 2002) developed by Argonne for CCC/USDA investigations in Nebraska should be consulted for complete details of the methods and procedures to be used at York.

  14. Forsmark site investigation. Programme for long-term observations of geosphere and biosphere after completed site investigations

    International Nuclear Information System (INIS)

    2007-06-01

    The site investigation at Forsmark was terminated the last of June, 2007. Hundreds of investigations have been conducted during a period of more than five years. Monitoring of a number of geoscientific parameters and biological objects has been one important part of the site investigation programme. Monitoring is defined as recurrent measurements of the same parameters/objects, so that time series are generated. Long-term monitoring of for example weather parameters, surface water discharge in brooks, and the groundwater head in a large number of boreholes has been conducted during the site investigations. Furthermore, repeated sampling of precipitation, surface water and groundwater in soil and rock for hydrochemical analyses has been carried out, and the groundwater flow in isolated borehole sections has been measured several times. Besides, some biological objects, for example rare bird species, have been invented each year of the site investigation. The measured parameters and the invented objects are characterized by a certain degree of time dependent variability, which is also site-specific. The aim of the monitoring is primarily to establish the 'undisturbed' conditions, the so called 'baseline'. If a deep repository is sited at Forsmark, many site-specific conditions will change, due to natural causes as well as to the construction works. Knowledge about the undisturbed conditions strengthens the ability to reveal and quantify such changes and to distinguish natural changes from those caused by the human activities. Another object of monitoring is to, by the study of the variability pattern of the monitored parameters, elevate the knowledge about the underlying, often complex causes governing the variations. In this way the description of site-specific conditions may be more precise and the prospects of modelling important processes are improved. After completion of the site investigations, a period of about two years will follow, when the investigation

  15. Forsmark site investigation. Programme for long-term observations of geosphere and biosphere after completed site investigations

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-06-15

    The site investigation at Forsmark was terminated the last of June, 2007. Hundreds of investigations have been conducted during a period of more than five years. Monitoring of a number of geoscientific parameters and biological objects has been one important part of the site investigation programme. Monitoring is defined as recurrent measurements of the same parameters/objects, so that time series are generated. Long-term monitoring of for example weather parameters, surface water discharge in brooks, and the groundwater head in a large number of boreholes has been conducted during the site investigations. Furthermore, repeated sampling of precipitation, surface water and groundwater in soil and rock for hydrochemical analyses has been carried out, and the groundwater flow in isolated borehole sections has been measured several times. Besides, some biological objects, for example rare bird species, have been invented each year of the site investigation. The measured parameters and the invented objects are characterized by a certain degree of time dependent variability, which is also site-specific. The aim of the monitoring is primarily to establish the 'undisturbed' conditions, the so called 'baseline'. If a deep repository is sited at Forsmark, many site-specific conditions will change, due to natural causes as well as to the construction works. Knowledge about the undisturbed conditions strengthens the ability to reveal and quantify such changes and to distinguish natural changes from those caused by the human activities. Another object of monitoring is to, by the study of the variability pattern of the monitored parameters, elevate the knowledge about the underlying, often complex causes governing the variations. In this way the description of site-specific conditions may be more precise and the prospects of modelling important processes are improved. After completion of the site investigations, a period of about two years will follow, when

  16. Site specific information in site selection

    International Nuclear Information System (INIS)

    Aeikaes, T.; Hautojaervi, A.

    1998-01-01

    The programme for the siting of a deep repository for final disposal of spent nuclear fuel was started already in 1983 and is carried out today by Posiva Oy which continues the work started by Teollisuuden Voima Oy. The programme aims at site selection by the end of the year 2000. The programme has progressed in successive interim stages with defined goals. After an early phase for site identification, five sites were selected in 1987 for preliminary site characterisation. Three of these were selected and judged to be best suited for the more detailed characterisation in 1992. An additional new site was included into the programme based on a separate feasibility study in the beginning of 1997. Since the year 1983 several safety assessments together with technical plans of the facility have been completed. When approaching the site selection the needs for more detailed consideration of the site specific properties in the safety assessment have been increased. The Finnish regulator STUK has published a proposal for general safety requirements for the final disposal of spent nuclear fuel in Finland. This set of requirements has been projected to be used in conjunction of the decision making by the end 2000. Based on the site evaluation all sites can provide a stable environment and there is evidence that the requirements for the longevity of the canister can be fulfilled at each site. In this manner the four candidate sites do not differ too much from each other. The main difference between the sites is in the salinity of the deep groundwater. The significance of differences in the salinity for the long-term safety cannot be defined yet. The differences may contribute to the discussion of the longevity of the bentonite buffer and also to the modelling of the groundwater flow and transport. The use of the geosphere as a transport barrier is basically culminated on the questions about sparse but fast flow routes and 'how bad channeling can be'. To answer these questions

  17. Remedial investigation/feasibility study work plan for the 300-FF-1 operable unit, Hanford Site, Richland, Washington

    International Nuclear Information System (INIS)

    1990-03-01

    Over 1,400 waste facilities have been identified on the Hanford Site. Most of the waste facilities are located within geographic areas on the Hanford Site that are referred to as the 100, 200, 300, 400, and 1100 areas. The purpose of this work plan is to document the project scoping process and to outline all remedial investigation/feasibility study (RI/FS) activities, to determine the nature and extent of the threat presented by releases of hazardous substances from the operable unit, and to evaluate proposed remedies for such releases. The goal of the 300-FF-1 remedial investigation (RI) is to provide sufficient information needed to conduct the feasibility study (FS), by determining the nature and extent of the threat to public health and the environment posed by releases of hazardous substances from 300-FF-1, and the performance of specific remedial technologies. 62 refs., 28 figs., 48 tabs

  18. Site description of Laxemar at completion of the site investigation phase. SDM-Site Laxemar

    Energy Technology Data Exchange (ETDEWEB)

    2009-12-15

    the waning stages of the Svecokarelian orogeny. The candidate area is circular-shaped with an area of 54 km2, and hosts the Laxemar subarea in its eastern part. The south-western part of the Laxemar subarea was selected as the focused area for the complete site investigation work, following the initial investigations at the site. Prior to the presentation of the SDM-Site report, three versions of a site descriptive model have been completed for the Laxemar-Simpevarp area and subjected to peer review. The last version, referred to as version Laxemar 1.2, constituted a preliminary site description that concluded the initial site investigation work and was presented in 2006. This preliminary site description formed the basis for a preliminary safety evaluation (PSE) of the Laxemar subarea, a preliminary repository layout, and the first evaluation of the long-term safety of this layout for a KBS-3 repository in the context of the SR-Can project. The final site descriptive model, SDM-Site Laxemar, builds on a coordinated geological model in 3D, into which other discipline-specific models have been integrated without any major conflicting interpretations. In particular, the bedrock thermal and strength properties of the bedrock at the site have been coupled to lithology and identified rock domains in the geological model and an integrated description has been devised that links the hydrogeology and the chemistry of the groundwater to hydraulic conductor domains (deformation zones) and hydraulic rock domains (and underlying fracture domains) and their division in depth zones. These mutually consistent results demonstrate that a fundamental understanding of the current state, properties and processes in Laxemar, from the surface down to potential repository depth, has been achieved. In addition, the properties of the area can be explained in the context of an understanding of its past evolution, throughout a long period of geological history. This integrated understanding of

  19. Site description of Laxemar at completion of the site investigation phase. SDM-Site Laxemar

    International Nuclear Information System (INIS)

    2009-12-01

    the waning stages of the Svecokarelian orogeny. The candidate area is circular-shaped with an area of 54 km 2 , and hosts the Laxemar subarea in its eastern part. The south-western part of the Laxemar subarea was selected as the focused area for the complete site investigation work, following the initial investigations at the site. Prior to the presentation of the SDM-Site report, three versions of a site descriptive model have been completed for the Laxemar-Simpevarp area and subjected to peer review. The last version, referred to as version Laxemar 1.2, constituted a preliminary site description that concluded the initial site investigation work and was presented in 2006. This preliminary site description formed the basis for a preliminary safety evaluation (PSE) of the Laxemar subarea, a preliminary repository layout, and the first evaluation of the long-term safety of this layout for a KBS-3 repository in the context of the SR-Can project. The final site descriptive model, SDM-Site Laxemar, builds on a coordinated geological model in 3D, into which other discipline-specific models have been integrated without any major conflicting interpretations. In particular, the bedrock thermal and strength properties of the bedrock at the site have been coupled to lithology and identified rock domains in the geological model and an integrated description has been devised that links the hydrogeology and the chemistry of the groundwater to hydraulic conductor domains (deformation zones) and hydraulic rock domains (and underlying fracture domains) and their division in depth zones. These mutually consistent results demonstrate that a fundamental understanding of the current state, properties and processes in Laxemar, from the surface down to potential repository depth, has been achieved. In addition, the properties of the area can be explained in the context of an understanding of its past evolution, throughout a long period of geological history. This integrated understanding

  20. RCRA facility investigation/corrective measures study work plan for the 200-UP-2 Operable Unit, Hanford Site, Richland, Washington

    International Nuclear Information System (INIS)

    1993-06-01

    The 200-UP-2 Operable Unit is one of two source operable units at the U Plant Aggregate Area at the Hanford Site. Source operable units include waste management units and unplanned release sites that are potential sources of radioactive and/or hazardous substance contamination. This work plan, while maintaining the title RFI/CMS, presents the background and direction for conducting a limited field investigation in the 200-UP-2 Operable Unit, which is the first part of the process leading to final remedy selection. This report discusses the background, prior recommendations, goals, organization, and quality assurance for the 200-UP-2 Operable Unit Work Plan. The discussion begins with a summary of the regulatory framework and the role of the work plan. The specific recommendations leading into the work plan are then addressed. Next, the goals and organization of the report are discussed. Finally, the quality assurance and supporting documentation are presented

  1. Site Safety Plan for Lawrence Livermore National Laboratory CERCLA investigations

    Energy Technology Data Exchange (ETDEWEB)

    Bainer, R.; Duarte, J.

    1993-07-01

    The safety policy of LLNL is to take every reasonable precaution in the performance of work to protect the environment and the health and safety of employees and the public, and to prevent property damage. With respect to hazardous agents, this protection is provided by limiting human exposures, releases to the environment, and contamination of property to levels that are as low as reasonably achievable (ALARA). It is the intent of this Plan to supply the broad outline for completing environmental investigations within ALARA guidelines. It may not be possible to determine actual working conditions in advance of the work; therefore, planning must allow the opportunity to provide a range of protection based upon actual working conditions. Requirements will be the least restrictive possible for a given set of circumstances, such that work can be completed in an efficient and timely fashion. Due to the relatively large size of the LLNL Site and the different types of activities underway, site-specific Operational Safety Procedures (OSPs) will be prepared to supplement activities not covered by this Plan. These site-specific OSPs provide the detailed information for each specific activity and act as an addendum to this Plan, which provides the general plan for LLNL Main Site operation.

  2. Hanford Site environmental management specification

    Energy Technology Data Exchange (ETDEWEB)

    Grygiel, M.L.

    1998-06-10

    The US Department of Energy, Richland Operations Office (RL) uses this Hanford Site Environmental Management Specification (Specification) to document top-level mission requirements and planning assumptions for the prime contractors involved in Hanford Site cleanup and infrastructure activities under the responsibility of the US Department of Energy, Office of Environmental Management. This Specification describes at a top level the activities, facilities, and infrastructure necessary to accomplish the cleanup of the Hanford Site and assigns this scope to Site contractors and their respective projects. This Specification also references the key National Environmental Policy Act of 1969 (NEPA), Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA), and safety documentation necessary to accurately describe the cleanup at a summary level. The information contained in this document reflects RL`s application of values, priorities, and critical success factors expressed by those involved with and affected by the Hanford Site project. The prime contractors and their projects develop complete baselines and work plans to implement this Specification. These lower-level documents and the data that support them, together with this Specification, represent the full set of requirements applicable to the contractors and their projects. Figure 1-1 shows the relationship of this Specification to the other basic Site documents. Similarly, the documents, orders, and laws referenced in this specification represent only the most salient sources of requirements. Current and contractual reference data contain a complete set of source documents.

  3. Hanford Site environmental management specification

    International Nuclear Information System (INIS)

    Grygiel, M.L.

    1998-01-01

    The US Department of Energy, Richland Operations Office (RL) uses this Hanford Site Environmental Management Specification (Specification) to document top-level mission requirements and planning assumptions for the prime contractors involved in Hanford Site cleanup and infrastructure activities under the responsibility of the US Department of Energy, Office of Environmental Management. This Specification describes at a top level the activities, facilities, and infrastructure necessary to accomplish the cleanup of the Hanford Site and assigns this scope to Site contractors and their respective projects. This Specification also references the key National Environmental Policy Act of 1969 (NEPA), Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA), and safety documentation necessary to accurately describe the cleanup at a summary level. The information contained in this document reflects RL's application of values, priorities, and critical success factors expressed by those involved with and affected by the Hanford Site project. The prime contractors and their projects develop complete baselines and work plans to implement this Specification. These lower-level documents and the data that support them, together with this Specification, represent the full set of requirements applicable to the contractors and their projects. Figure 1-1 shows the relationship of this Specification to the other basic Site documents. Similarly, the documents, orders, and laws referenced in this specification represent only the most salient sources of requirements. Current and contractual reference data contain a complete set of source documents

  4. Site description of Forsmark at completion of the site investigation phase. SDM-Site Forsmark

    Energy Technology Data Exchange (ETDEWEB)

    2008-12-15

    north-western part of the candidate area lacks hydraulically conductive, gently dipping fracture zones at potential repository depth and was selected as the target area for the complete site investigation work, following the initial investigations at the site. Prior to the presentation of the SDM-Site report, three versions of a site descriptive model have been completed for the Forsmark area and presented for peer review. The last version, referred to as version 1.2, was a preliminary site description that concluded the initial site investigation work and was presented in 2005. This preliminary site description formed the basis for a preliminary safety evaluation (PSE) of the Forsmark area, a preliminary repository layout (step D1), and the first evaluation of the long-term safety of this layout for KBS-3 repositories in the context of the SR-Can project. The final site descriptive model, SDM-Site, builds on a coordinated geological model in 3D, into which other discipline-specific models have been integrated without any major conflicting interpretations. In particular, the thermal properties of the bedrock at the site have been coupled to identified rock domains in the geological model and an integrated model that links the current stress regime, the hydrogeology and the chemistry of the groundwater to fracture domains and fracture zones in the geological model has evolved. These mutually consistent results demonstrate that a fundamental understanding of the current state of conditions and the on-going processes in the Forsmark area, from the surface down to potential repository depth, has been achieved. In addition, the properties of the area can be explained in the context of an understanding of the past evolution, throughout a long period of geological history. This integrated understanding of the area is presented in chapter 11 of this report and this chapter serves as an executive summary. A systematic assessment of the confidence in the model, including

  5. Site description of Forsmark at completion of the site investigation phase. SDM-Site Forsmark

    International Nuclear Information System (INIS)

    2008-12-01

    north-western part of the candidate area lacks hydraulically conductive, gently dipping fracture zones at potential repository depth and was selected as the target area for the complete site investigation work, following the initial investigations at the site. Prior to the presentation of the SDM-Site report, three versions of a site descriptive model have been completed for the Forsmark area and presented for peer review. The last version, referred to as version 1.2, was a preliminary site description that concluded the initial site investigation work and was presented in 2005. This preliminary site description formed the basis for a preliminary safety evaluation (PSE) of the Forsmark area, a preliminary repository layout (step D1), and the first evaluation of the long-term safety of this layout for KBS-3 repositories in the context of the SR-Can project. The final site descriptive model, SDM-Site, builds on a coordinated geological model in 3D, into which other discipline-specific models have been integrated without any major conflicting interpretations. In particular, the thermal properties of the bedrock at the site have been coupled to identified rock domains in the geological model and an integrated model that links the current stress regime, the hydrogeology and the chemistry of the groundwater to fracture domains and fracture zones in the geological model has evolved. These mutually consistent results demonstrate that a fundamental understanding of the current state of conditions and the on-going processes in the Forsmark area, from the surface down to potential repository depth, has been achieved. In addition, the properties of the area can be explained in the context of an understanding of the past evolution, throughout a long period of geological history. This integrated understanding of the area is presented in chapter 11 of this report and this chapter serves as an executive summary. A systematic assessment of the confidence in the model, including

  6. Hanford Site Environmental Management Specification

    International Nuclear Information System (INIS)

    DAILY, J.L.

    2001-01-01

    The US Department of Energy, Richland Operations Office (RL) has established a document hierarchy as part of its integrated management system. The Strategic Plan defines the vision, values, missions, strategic goals, high-level outcomes, and the basic strategies in achieving those outcomes. As shown in Figure 1-1, the Site Specification derives requirements from the Strategic Plan and documents the top-level mission technical requirements for the work involved in the RL Hanford Site cleanup and infrastructure activities under the responsibility of the U.S. Department of Energy, Office of Environmental Management (EM). It also provides the basis for all contract technical requirements. Since this is limited to the EM work, neither the Fast Flux Test Facility (FFTF) nor the Pacific Northwest National Laboratory (PNNL) non-EM science activities are included. Figure 1-1 also shows the relationship between this Site Specification and the other Site management and planning documents. Similarly, the documents, orders, and laws referenced in this document represent only the most salient sources of requirements. Current and contractual reference data contain a complete set of source documents

  7. The role of historical operations information for supporting remedial investigation work at the former Harshaw Chemical Site

    International Nuclear Information System (INIS)

    Johnson, R.; Peterson, J.; Picel, K.; Kolhoff, A.; Devaughn, J.

    2008-01-01

    In the early stages of hazardous, toxic, and radioactive waste (HTRW) site investigations, basic record searches are performed to help direct the agencies investigating contaminated sites to areas of concern and to identify contaminants of interest (COI). Plans developed on the basis of this preliminary research alone are often incomplete and result in unexpected discoveries either while in the field investigating the site or after the reports have been written. Many of the sites investigated under the Formerly Utilized Sites Remedial Action program (FUSRAP) have complex histories that are slowly uncovered over the life of the project. Because of programmatic constraints, nuances of these sites are often discovered late in their programs and result in increased expenditures in order to fully characterize the site, perform a robust feasibility study, and recommend appropriate alternatives for remediation. By identifying resources for public records, classified records, historic aerial photographs, and other sources of site-specific historical information, a process can be established to optimize the collection of information and to develop efficient and complete project plans. In many cases, interviews with past site employees are very useful tools. In combining what is found in the records, observed on historic aerial photographs, and heard from former employees and family members, teams investigating these sites can begin to compile sound and more complete conceptual site models (CSMs). The former Harshaw Chemical Site (HCS) illustrates this discovery process. HCS is part of FUSRAP. Preliminary investigations by the US Department of Energy (DOE) in the 1970s provided an initial CSM of activities that had taken place that may have resulted in contamination. The remedial investigation (RI) conducted by the US Army Corps of Engineers (USACE) was designed around this CSM. The RI work, however, identified a number of site conditions that were unexpected, including new

  8. When is there sufficient information from the Site Investigations?

    International Nuclear Information System (INIS)

    Andersson, Johan; Munier, Raymond; Stroem, Anders; Soederbaeck, Bjoern; Almen, Karl-Erik; Olsson, Lars

    2004-04-01

    SKB has started site investigations for a deep repository for spent nuclear fuel at two different sites in Sweden. The investigations should provide necessary information for a licence application aimed at starting underground exploration. The investigations and analyses of them are supposed to provide the broad knowledge base that is required to achieve the overall goals of the site investigation phase. The knowledge will be utilized to evaluate the suitability of investigated sites for the deep repository and must be comprehensive enough to: Show whether the selected site satisfies requirements on safety and technical aspects. Serve as a basis for adaptation of the deep repository to the characteristics of the site with an acceptable impact on society and the environment. Permit comparisons with other investigated sites. Furthermore, the investigations are discontinued when the reliability of the site description has reached such a level that the body of data for safety assessment and design is sufficient, or until the body of data shows that the rock does not satisfy the requirements. These objectives are valid, but do not provide sufficient and concrete guidance. For this reason SKB has conducted this project which should acquire concrete guidance on how to judge when the surface based Site Investigation Phase does not need to continue. After a general assessment of the problem, the following specific objectives of the current work were identified: Demonstrate concretely how the assessed uncertainties in a Site Description based on a specific level of investigations, together with expected feedback from Safety Assessment and Engineering, can be used to decide whether the site investigations are sufficient - or need to continue. This demonstration will be based on a practical application of relevant aspects of decision analysis tools. Highlight and make concrete the type of feedback to be expected from Safety Assessment and Engineering and show how this feedback

  9. When is there sufficient information from the Site Investigations?

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, Johan [JA Streamflow AB, Aelvsjoe (Sweden); Munier, Raymond; Stroem, Anders; Soederbaeck, Bjoern [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden); Almen, Karl-Erik [KEA Geo-konsult (Sweden); Olsson, Lars [Geostatistik AB, Tumba (Sweden)

    2004-04-01

    SKB has started site investigations for a deep repository for spent nuclear fuel at two different sites in Sweden. The investigations should provide necessary information for a licence application aimed at starting underground exploration. The investigations and analyses of them are supposed to provide the broad knowledge base that is required to achieve the overall goals of the site investigation phase. The knowledge will be utilized to evaluate the suitability of investigated sites for the deep repository and must be comprehensive enough to: Show whether the selected site satisfies requirements on safety and technical aspects. Serve as a basis for adaptation of the deep repository to the characteristics of the site with an acceptable impact on society and the environment. Permit comparisons with other investigated sites. Furthermore, the investigations are discontinued when the reliability of the site description has reached such a level that the body of data for safety assessment and design is sufficient, or until the body of data shows that the rock does not satisfy the requirements. These objectives are valid, but do not provide sufficient and concrete guidance. For this reason SKB has conducted this project which should acquire concrete guidance on how to judge when the surface based Site Investigation Phase does not need to continue. After a general assessment of the problem, the following specific objectives of the current work were identified: Demonstrate concretely how the assessed uncertainties in a Site Description based on a specific level of investigations, together with expected feedback from Safety Assessment and Engineering, can be used to decide whether the site investigations are sufficient - or need to continue. This demonstration will be based on a practical application of relevant aspects of decision analysis tools. Highlight and make concrete the type of feedback to be expected from Safety Assessment and Engineering and show how this feedback

  10. A working group`s conclusion on site specific flow and transport modelling

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, J. [Golder Associates AB (Sweden); Ahokas, H. [Fintact Oy, Helsinki (Finland); Koskinen, L.; Poteri, A. [VTT Energy, Espoo (Finland); Niemi, A. [Royal Inst. of Technology, Stockholm (Sweden). Hydraulic Engineering; Hautojaervi, A. [Posiva Oy, Helsinki (Finland)

    1998-03-01

    This document suggests a strategy plan for groundwater flow and transport modelling to be used in the site specific performance assessment analysis of spent nuclear fuel disposal to be used for the site selection planned by the year 2000. Considering suggested general regulations in Finland, as well as suggested regulations in Sweden and the approach taken in recent safety assessment exercises conducted in these countries, it is clear that in such an analysis, in addition to showing that the proposed repository is safe, there exist needs to strengthen the link between field data, groundwater flow modelling and derivation of safety assessment parameters, and needs to assess uncertainty and variability. The suggested strategy plan builds on an evaluation of different approaches to modelling the groundwater flow in crystalline basement rock, the abundance of data collected in the site investigation programme in Finland, and the modelling methodology developed in the programme so far. It is suggested to model the whole system using nested models, where larger scale models provide the boundary conditions for the smaller ones 62 refs.

  11. Thermal Site Descriptive Model. A strategy for the model development during site investigations. Version 1.0

    International Nuclear Information System (INIS)

    Sundberg, Jan

    2003-04-01

    Site investigations are in progress for the siting of a deep repository for spent nuclear fuel. As part of the planning work, strategies are developed for site descriptive modelling regarding different disciplines, amongst them the thermal conditions. The objective of the strategy for a thermal site descriptive model is to guide the practical implementation of evaluating site specific data during the site investigations. It is understood that further development may be needed. The model describes the thermal properties and other thermal parameters of intact rock, fractures and fracture zones, and of the rock mass. The methodology is based on estimation of thermal properties of intact rock and discontinuities, using both empirical and theoretical/numerical approaches, and estimation of thermal processes using mathematical modelling. The methodology will be used and evaluated for the thermal site descriptive modelling at the Aespoe Hard Rock Laboratory

  12. Site investigations for the disposal of spent fuel - investigation program

    International Nuclear Information System (INIS)

    Aeikaes, Timo

    1985-11-01

    The Industrial Power Company Ltd (TVO) is making preparations for the final disposal of spent nuclear fuel into the Finnish bedrock. The revised site investigation program for the years 1986-2010 is presented in this report. The objectives and activities in the near future are described in more detail. The main objectives and frame programs for the investigations in the more distant future are described. The program planning of these investigations are being developed in the preceding site investigations. The investigations for the site selection are divided into four phases: 1983-1985 selection of the investigation areas, preparations for the field investigations, drilling and investigations in a deep test borehole; 1986-1992 preliminary site investigations in 5-10 investigation areas; 1993-2000 detailed site investigations in 2-3 investigation areas. Site selection in the year 2000; 2001-2010 complementary investigations on the selected site. The first investigation phase will be carried out as planned. In this phase a 1001 m deep test borehole was drilled at Lavia in western Finland. With the investigations in the borehole and related development work, preparations were made for the future field investigations. The equipment and investigation methods are being developed during the site investigations. The equipment for taking groundwater samples and the unit for hydraulic testing have been developed. In the future the emphasis in the work will be in developing equipment for monitoring of the hydraulic head and measuring the volumetric flow. In groundwater sampling the present procedure can be improved by adding the test for the in-situ measurements. The results of the field investigations will be stored and processed in a centralized data base. The data base will transmit the results for the interpretation and then the interpreted results transmitted for model calculations and reporting. The cost estimate for the investigations in 1986-2010 is 110-125 million

  13. Site investigations: Strategy for rock mechanics site descriptive model

    International Nuclear Information System (INIS)

    Andersson, Johan; Christiansson, Rolf; Hudson, John

    2002-05-01

    As a part of the planning work for the Site Investigations, SKB has developed a Rock Mechanics Site Descriptive Modelling Strategy. Similar strategies are being developed for other disciplines. The objective of the strategy is that it should guide the practical implementation of evaluating site specific data during the Site Investigations. It is also understood that further development may be needed. This methodology enables the crystalline rock mass to be characterised in terms of the quality at different sites, for considering rock engineering constructability, and for providing the input to numerical models and performance assessment calculations. The model describes the initial stresses and the distribution of deformation and strength properties of the intact rock, of fractures and fracture zones, and of the rock mass. The rock mass mechanical properties are estimated by empirical relations and by numerical simulations. The methodology is based on estimation of mechanical properties using both empirical and heroretical/numerical approaches; and estimation of in situ rock stress using judgement and numerical modelling, including the influence of fracture zones. These approaches are initially used separately, and then combined to produce the required characterisation estimates. The methodology was evaluated with a Test Case at the Aespoe Hard Rock Laboratory in Sweden. The quality control aspects are an important feature of the methodology: these include Protocols to ensure the structure and coherence of the procedures used, regular meetings to enhance communication, feedback from internal and external reviewing, plus the recording of an audit trail of the development steps and decisions made. The strategy will be reviewed and, if required, updated as appropriate

  14. Site investigations: Strategy for rock mechanics site descriptive model

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, Johan [JA Streamflow AB, Aelvsjoe (Sweden); Christiansson, Rolf [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden); Hudson, John [Rock Engineering Consultants, Welwyn Garden City (United Kingdom)

    2002-05-01

    As a part of the planning work for the Site Investigations, SKB has developed a Rock Mechanics Site Descriptive Modelling Strategy. Similar strategies are being developed for other disciplines. The objective of the strategy is that it should guide the practical implementation of evaluating site specific data during the Site Investigations. It is also understood that further development may be needed. This methodology enables the crystalline rock mass to be characterised in terms of the quality at different sites, for considering rock engineering constructability, and for providing the input to numerical models and performance assessment calculations. The model describes the initial stresses and the distribution of deformation and strength properties of the intact rock, of fractures and fracture zones, and of the rock mass. The rock mass mechanical properties are estimated by empirical relations and by numerical simulations. The methodology is based on estimation of mechanical properties using both empirical and heroretical/numerical approaches; and estimation of in situ rock stress using judgement and numerical modelling, including the influence of fracture zones. These approaches are initially used separately, and then combined to produce the required characterisation estimates. The methodology was evaluated with a Test Case at the Aespoe Hard Rock Laboratory in Sweden. The quality control aspects are an important feature of the methodology: these include Protocols to ensure the structure and coherence of the procedures used, regular meetings to enhance communication, feedback from internal and external reviewing, plus the recording of an audit trail of the development steps and decisions made. The strategy will be reviewed and, if required, updated as appropriate.

  15. Execution programme for the initial site investigations at Simpevarp

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-10-01

    In the feasibility studies that were completed in 2001, eight sites were identified as potentially suitable for hosting a repository. All the identified sites meet the safety requirements with respect to bedrock conditions that could be checked at that time. The feasibility studies have revealed good potential when it comes to the technical and environmental aspects as well. Based on an integrated evaluation SKB proposed to start site investigations with test drillings at three sites; Simpevarp, Forsmark, and Tierp north. The site investigations have started at Simpevarp and Forsmark. The municipal council of Tierp rejected a site investigation in April 2002. The site investigations are divided into two main phases; initial and complete investigations. Initial Site Investigation is performed to identify the site within a specified area that is deemed to be most suitable for a deep repository and to determine whether the feasibility study's judgement of the suitability of the area holds up in the light of borehole data from repository depth. The Initial Site Investigation is expected to take about 3 years. If the assessment shows that the site has good potential to host a repository, Complete Site Investigation will follow for an expected duration of another 3 years. The purpose of the Complete Site Investigation is to gather all information required to select one of the sites as the main alternative and to apply for a permit for construction of the deep repository at that site. The site-specific programme gives an overview of the whole site investigation phase as well as a detailed description of the initial stage. The results of the initial investigations will determine whether Simpevarp is appropriate for further investigation, i.e. the Complete Site Investigation. This document summarizes the investigations that will be carried out at Simpevarp during the Initial Site Investigations. The document is a working document, which will be successively updated as

  16. Execution programme for the initial site investigations at Simpevarp

    International Nuclear Information System (INIS)

    2002-10-01

    In the feasibility studies that were completed in 2001, eight sites were identified as potentially suitable for hosting a repository. All the identified sites meet the safety requirements with respect to bedrock conditions that could be checked at that time. The feasibility studies have revealed good potential when it comes to the technical and environmental aspects as well. Based on an integrated evaluation SKB proposed to start site investigations with test drillings at three sites; Simpevarp, Forsmark, and Tierp north. The site investigations have started at Simpevarp and Forsmark. The municipal council of Tierp rejected a site investigation in April 2002. The site investigations are divided into two main phases; initial and complete investigations. Initial Site Investigation is performed to identify the site within a specified area that is deemed to be most suitable for a deep repository and to determine whether the feasibility study's judgement of the suitability of the area holds up in the light of borehole data from repository depth. The Initial Site Investigation is expected to take about 3 years. If the assessment shows that the site has good potential to host a repository, Complete Site Investigation will follow for an expected duration of another 3 years. The purpose of the Complete Site Investigation is to gather all information required to select one of the sites as the main alternative and to apply for a permit for construction of the deep repository at that site. The site-specific programme gives an overview of the whole site investigation phase as well as a detailed description of the initial stage. The results of the initial investigations will determine whether Simpevarp is appropriate for further investigation, i.e. the Complete Site Investigation. This document summarizes the investigations that will be carried out at Simpevarp during the Initial Site Investigations. The document is a working document, which will be successively updated as

  17. Prioritization to limit sampling and drilling in site investigations

    International Nuclear Information System (INIS)

    Burton, J.C.

    1992-01-01

    One of the major goals of the Environmental Research Division of Argonne National Laboratory is to develop and provide governmental agencies with technically sound, cost-effective frameworks for environmental site characterization and remedial programs. An example of the development of such a framework for preremedial site characterization is presented in this paper. Specifically, this paper presents portions of an expanded site investigation program developed for landfills suspected of containing hazardous waste. The work was sponsored by the New Mexico State Office of the US Department of Interior's Bureau of Land Management (BLM). The emphasis of the BLM program was on identifying initial characterization procedures that would decrease the need for sampling and drilling on a random grid

  18. Incorporating ecological risk assessment into remedial investigation/feasibility study work plans

    International Nuclear Information System (INIS)

    1994-06-01

    This guidance document (1) provides instructions on preparing the components of an ecological work plan to complement the overall site remedial investigation/feasibility study (RI/FS) work plan and (2) directs the user on how to implement ecological tasks identified in the plan. Under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA), as amended by the Superfund Amendments and Reauthorization Act of 1986 (SARA), and RI/FS work plan will have to be developed as part of the site-remediation scoping process. Specific guidance on the RI/FS process and the preparation of work plans has been developed by the US Environmental Protection Agency (EPA 1988a). This document provides guidance to US Department of Energy (DOE) staff and contractor personnel for incorporation of ecological information into environmental remediation planning and decision making at CERCLA sites

  19. Incorporating ecological risk assessment into remedial investigation/feasibility study work plans

    Energy Technology Data Exchange (ETDEWEB)

    1994-06-01

    This guidance document (1) provides instructions on preparing the components of an ecological work plan to complement the overall site remedial investigation/feasibility study (RI/FS) work plan and (2) directs the user on how to implement ecological tasks identified in the plan. Under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA), as amended by the Superfund Amendments and Reauthorization Act of 1986 (SARA), and RI/FS work plan will have to be developed as part of the site-remediation scoping process. Specific guidance on the RI/FS process and the preparation of work plans has been developed by the US Environmental Protection Agency (EPA 1988a). This document provides guidance to US Department of Energy (DOE) staff and contractor personnel for incorporation of ecological information into environmental remediation planning and decision making at CERCLA sites.

  20. Site-specific design optimization of wind turbines

    DEFF Research Database (Denmark)

    Fuglsang, P.; Bak, C.; Schepers, J.G.

    2002-01-01

    This article reports results from a European project, where site characteristics were incorporated into the design process of wind turbines, to enable site-specific design. Two wind turbines of different concept were investigated at six different sites comprising normal flat terrain, offshore...... and complex terrain wind farms. Design tools based on numerical optimization and aeroelastic calculations were combined with a cost model to allow optimization for minimum cost of energy. Different scenarios were optimized ranging from modifications of selected individual components to the complete design...... of a new wind turbine. Both annual energy yield and design-determining loads depended on site characteristics, and this represented a potential for site-specific design. The maximum variation in annual energy yield was 37% and the maximum variation in blade root fatigue loads was 62%. Optimized site...

  1. Work plan for the remedial investigation/feasibility study-environmental assessment for the Colonie site, Colonie, New York

    International Nuclear Information System (INIS)

    1990-06-01

    This work plan has been prepared to document the scoping and planning process performed by the US Department of Energy (DOE) to support remedial action activities at the Colonie site. The site is located in eastern New York State in the town of Colonie near the city of Albany. Remedial action of the Colonie site is being planned as part of DOE's Formerly Utilized Sites Remedial Action Program. The DOE is responsible for controlling the release of all radioactive and chemical contaminants from the site. Under the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), a remedial investigation/feasibility study (RI/FS) must be prepared to support the decision-making process for evaluating remedial action alternatives. This work plan contains a summary of information known about the site as of January 1988, presents a conceptual site model that identifies potential routes of human exposure to site containments, identifies data gaps, and summarizes the process and proposed studies that will be used to fill the data gaps. In addition, DOE activities must be conducted in compliance with the National Environmental Policy Act (NEPA), which requires consideration of the environmental consequences of a proposed action as part of its decision-making process. This work also describes the approach that will be used to evaluate potential remedial action alternatives and includes a description of the organization, project controls, and task schedules that will be employed to fulfill the requirements of both CERCLA and NEPA. 48 refs., 18 figs., 25 tabs

  2. Site-Specific PEGylation of Therapeutic Proteins

    Directory of Open Access Journals (Sweden)

    Jonathan K. Dozier

    2015-10-01

    Full Text Available The use of proteins as therapeutics has a long history and is becoming ever more common in modern medicine. While the number of protein-based drugs is growing every year, significant problems still remain with their use. Among these problems are rapid degradation and excretion from patients, thus requiring frequent dosing, which in turn increases the chances for an immunological response as well as increasing the cost of therapy. One of the main strategies to alleviate these problems is to link a polyethylene glycol (PEG group to the protein of interest. This process, called PEGylation, has grown dramatically in recent years resulting in several approved drugs. Installing a single PEG chain at a defined site in a protein is challenging. Recently, there is has been considerable research into various methods for the site-specific PEGylation of proteins. This review seeks to summarize that work and provide background and context for how site-specific PEGylation is performed. After introducing the topic of site-specific PEGylation, recent developments using chemical methods are described. That is followed by a more extensive discussion of bioorthogonal reactions and enzymatic labeling.

  3. Remedial investigation/feasibility study work plan for the 100-BC-2 operable unit, Hanford Site, Richland, Washington

    International Nuclear Information System (INIS)

    1993-05-01

    This work plan and attached supporting project plans establish the operable unit setting and the objectives, procedures, tasks, and schedule for conducting the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) remedial investigation/feasibility study (RI/FS) for the 100-BC-2 operable unit in the 100 Area of the Hanford Site. The 100 Area is one of four areas at the Hanford Site that are on the US Environmental Protection Agency's (EPA) National Priorities List under CERCLA. The 100-BC-2 operable unit is one of two source operable units in the 100-B/C Area (Figure ES-1). Source operable units are those that contain facilities and unplanned release sites that are potential sources of hazardous substance contamination. The 100-BC-2 source operable unit contains waste sites that were formerly in the 100-BC-2, 100-BC-3, and 100-BC-4 operable units. Because of their size and geographic location, the waste sites from these two operable units were added to 100-BC-2. This allows for a more efficient and effective investigation of the remaining 100-B/C Reactor area waste sites. The investigative approach to waste sites associated with the 100-BC-2 operable unit are listed in Table ES-1. The waste sites fall into three general categories: high priority liquid waste disposal sites, low priority liquid waste disposal sites, and solid waste burial grounds. Several sites have been identified as candidates for conducting an IRM. Two sites have been identified as warranting additional limited field sampling. The two sites are the 116-C-2A pluto crib, and the 116-C-2C sand filter

  4. Teachers' Occupation-Specific Work-Family Conflict

    Science.gov (United States)

    Cinamon, Rachel Gali; Rich, Yisrael; Westman, Mina

    2007-01-01

    To expand work-family conflict (WFC) research to specific occupations, this study investigated how work and family generic and occupation-specific stressors and support variables related to family interfering with work (F [right arrow] W) and work interfering with family (W [right arrow] F) among 230 Israeli high school teachers. Further expanding…

  5. Site 300 hazardous-waste-assessment project. Interim report: December 1981. Preliminary site reconnaissance and project work plan

    International Nuclear Information System (INIS)

    Raber, E.; Helm, D.; Carpenter, D.; Peifer, D.; Sweeney, J.

    1982-01-01

    This document was prepared to outline the scope and objectives of the Hazardous Waste Assessment Project (HWAP) at Site 300. This project was initiated in October, 1981, to investigate the existing solid waste landfills in an effort to satisfy regulatory guidelines and assess the potential for ground-water contamination. This involves a site-specific investigation (utilizing geology, hydrology, geophysics and geochemistry) with the goal of developing an effective ground-water quality monitoring network. Initial site reconnaissance work has begun and we report the results, to date, of our geologic hydrogeologic studies. All known solid waste disposal locations are underlain by rocks of either the Late Miocene Neroly Formation or the Cierbo Formation, both of which are dominantly sandstones interbedded with shale and claystone. The existence of a regional confined (artesian) aquifer, as well as a regional water-table aquifer is postulated for Site 300. Preliminary analysis has led to an understanding of directions and depths of regional ground-water flow

  6. Parameters of importance to determine during geoscientific site investigation

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, Johan [QuantiSci AB (Sweden); Almen, K.E. [KEA GEO-Konsult AB (Sweden); Ericsson, Lars O.; Karlsson, Fred; Stroem, A. [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden); Fredriksson, Anders [ADG Grundteknik AB (Sweden); Stanfors, R. [Roy Stanfors Consulting AB (Sweden)

    1998-06-01

    This document identifies and describes geo-scientific parameters that are of importance in order to carry out performance and safety assessments of a deep repository for spent nuclear fuel, based on the information that can be obtained from a site investigation. The document also discusses data needs for planning and design of the rock works and for description of other environmental aspects. Evaluation of the different parameters is discussed in the document as well. The document was produced by a working group consisting of the authors and various SKB staff and consultants, and comprises a step in the planning of a geo-scientific investigation programme at the sites where site investigations will be conducted. The goals of the work presented in this report can be derived directly from SKBs ongoing RD and D Programme. The programme stipulates that a geo-scientific site investigation programme must be available before a site investigation begins. This programme is supposed to specify the goals, measurement methods and evaluation methodology, as well as the acceptance criteria against which the site is evaluated. It is pointed out that site evaluation is a collective term for an interactive process consisting of different parts 65 refs, 15 figs, 12 tabs

  7. Site observational work plan for the UMTRA Project site at Falls City, Texas

    International Nuclear Information System (INIS)

    1995-06-01

    Produced by the US Department of Energy (DOE), this site observational work plan (SOWP) will be used to determine site-specific activities to comply with the US Environmental Protection Agency (EPA) ground water standards at this Uranium Mill Tailings Remedial Action (UMTRA) Project site. The purpose of the SOWP is to recommend a site-specific ground water compliance strategy at the Falls City UMTRA Project site. The Falls City SOWP presents a comprehensive summary of site hydrogeological data, delineates a conceptual model of the aquifer system, and discusses the origins of milling-related ground water contamination. It also defines the magnitude of ground water contamination, potential environmental and health risks associated with ground water contamination and data gaps, and targets a proposed compliance strategy

  8. Forsmark site investigation. Programme for further investigations of geosphere and biosphere

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-01-01

    Since the beginning of 2002, SKB (the Swedish Nuclear Fuel and Waste Management Co) has been conducting a site investigation in Forsmark in the municipality of Oesthammar for siting of the deep repository for spent nuclear fuel. An equivalent investigation is also being conducted at Simpevarp and Laxemar in Oskarshamn Municipality. SKB's goal is to submit an application under the Environmental Code and the Nuclear Activities Act for siting of the deep repository at one of these sites by the end of 2008/beginning of 2009. When the application is submitted, everything of importance for the deep repository's safety, constructability and environmental impact shall have been investigated and analyzed. The investigations shall also provide data as a basis for selecting a site and configuring the facility to suit conditions on the site.SKB submitted a programme for the initial site investigation in Forsmark at the end of 2001. The investigations described there have now been completed. This report describes the programme that has now been prepared for the remainder of the site investigation. The points of departure are the general goals for the Deep Repository Project during the site investigation phase, the data needed for evaluation of the site, plus experience and results from the work to date. The programme has been prepared with the support of investigation data as of August 2004. The investigations described here will, as before, be conducted with great consideration given to residents, property owners and natural and cultural values so that they are not unnecessarily exposed to impact or disturbances. Just as before, the programme will be continuously adapted to the knowledge that is gradually accumulated on the site. All important changes will be reported to the authorities and other concerned parties. The investigations that have been conducted (as of August 2004) and their results can be summarized in the following points: The surface characterization

  9. Forsmark site investigation. Programme for further investigations of geosphere and biosphere

    International Nuclear Information System (INIS)

    2005-01-01

    Since the beginning of 2002, SKB (the Swedish Nuclear Fuel and Waste Management Co) has been conducting a site investigation in Forsmark in the municipality of Oesthammar for siting of the deep repository for spent nuclear fuel. An equivalent investigation is also being conducted at Simpevarp and Laxemar in Oskarshamn Municipality. SKB's goal is to submit an application under the Environmental Code and the Nuclear Activities Act for siting of the deep repository at one of these sites by the end of 2008/beginning of 2009. When the application is submitted, everything of importance for the deep repository's safety, constructability and environmental impact shall have been investigated and analyzed. The investigations shall also provide data as a basis for selecting a site and configuring the facility to suit conditions on the site.SKB submitted a programme for the initial site investigation in Forsmark at the end of 2001. The investigations described there have now been completed. This report describes the programme that has now been prepared for the remainder of the site investigation. The points of departure are the general goals for the Deep Repository Project during the site investigation phase, the data needed for evaluation of the site, plus experience and results from the work to date. The programme has been prepared with the support of investigation data as of August 2004. The investigations described here will, as before, be conducted with great consideration given to residents, property owners and natural and cultural values so that they are not unnecessarily exposed to impact or disturbances. Just as before, the programme will be continuously adapted to the knowledge that is gradually accumulated on the site. All important changes will be reported to the authorities and other concerned parties. The investigations that have been conducted (as of August 2004) and their results can be summarized in the following points: The surface characterization of the

  10. Geological Site Descriptive Model. A strategy for the model development during site investigations

    Energy Technology Data Exchange (ETDEWEB)

    Munier, Raymond; Stenberg, Leif [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden); Stanfors, Roy [Roy Stanfors Consulting, Lund (Sweden); Milnes, Allan Geoffrey [GEA Consulting, Uppsala (Sweden); Hermanson, Jan [Golder Associates, Stockholm (Sweden); Triumf, Carl-Axel [Geovista, Luleaa (Sweden)

    2003-04-01

    The Swedish Nuclear Fuel and Waste Management Company (SKB) is at present conducting site investigations as a preliminary to building an underground nuclear waste disposal facility in Sweden. This report presents a methodology for constructing, visualising and presenting 3-dimensional geological models, based on data from the site investigations. The methodology integrates with the overall work-flow of the site investigations, from the collection of raw data to the complete site description, as proposed in several earlier technical reports. Further, it is specifically designed for interaction with SICADA - SKB's Site Characterisation Database - and RVS - SKB's Rock Visualisation System. This report is one in a series of strategy documents intended to demonstrate how modelling is to be performed within each discipline. However, it also has a wider purpose, since the geological site descriptive model provides the basic geometrical framework for all the other disciplines. Hence, the wider aim is to present a practical and clear methodology for the analysis and interpretation of input data for use in the construction of the geology-based 3D geometrical model. In addition to the various aspects of modelling described above, the methodology presented here should therefore also provide: guidelines and directives on how systematic interpretation and integration of geo-scientific data from the different investigation methods should be carried out; guidelines on how different geometries should be created in the geological models; guidelines on how the assignment of parameters to the different geological units in RVS should be accomplished; guidelines on the handling of uncertainty at different points in the interpretation process. In addition, it should clarify the relation between the geological model and other models used in the processes of site characterisation, repository layout and safety analysis. In particular, integration and transparency should be

  11. Geological Site Descriptive Model. A strategy for the model development during site investigations

    International Nuclear Information System (INIS)

    Munier, Raymond; Stenberg, Leif; Stanfors, Roy; Milnes, Allan Geoffrey; Hermanson, Jan; Triumf, Carl-Axel

    2003-04-01

    The Swedish Nuclear Fuel and Waste Management Company (SKB) is at present conducting site investigations as a preliminary to building an underground nuclear waste disposal facility in Sweden. This report presents a methodology for constructing, visualising and presenting 3-dimensional geological models, based on data from the site investigations. The methodology integrates with the overall work-flow of the site investigations, from the collection of raw data to the complete site description, as proposed in several earlier technical reports. Further, it is specifically designed for interaction with SICADA - SKB's Site Characterisation Database - and RVS - SKB's Rock Visualisation System. This report is one in a series of strategy documents intended to demonstrate how modelling is to be performed within each discipline. However, it also has a wider purpose, since the geological site descriptive model provides the basic geometrical framework for all the other disciplines. Hence, the wider aim is to present a practical and clear methodology for the analysis and interpretation of input data for use in the construction of the geology-based 3D geometrical model. In addition to the various aspects of modelling described above, the methodology presented here should therefore also provide: guidelines and directives on how systematic interpretation and integration of geo-scientific data from the different investigation methods should be carried out; guidelines on how different geometries should be created in the geological models; guidelines on how the assignment of parameters to the different geological units in RVS should be accomplished; guidelines on the handling of uncertainty at different points in the interpretation process. In addition, it should clarify the relation between the geological model and other models used in the processes of site characterisation, repository layout and safety analysis. In particular, integration and transparency should be promoted. The

  12. Site observational work plan for the UMTRA Project site at Spook, Wyoming

    International Nuclear Information System (INIS)

    1995-05-01

    The Spook, Wyoming, site observational work plan proposes site-specific activities to achieve compliance with Subpart B of 40 CFR Part 192 (1994) of the final US Environmental Protection Agency (EPA) ground water protection standards 60 FR 2854 (1995) at this Uranium Mill Tailing Remedial Action (UMTRA) Project site. This draft SOWP presents a comprehensive summary of existing site characterization data, a conceptual site model of the nature and extent of ground water contamination, exposure pathways, and potential impact to human health and the environment. Section 2.0 describes the requirements for meeting ground water standards at UMTRA Project sites. Section 3.0 defines past and current conditions, describes potential environmental and human health risks, and provides site-specific data that supports the selection of a proposed ground water compliance strategy. Section 4.0 provides the justification for selecting the proposed ground water compliance strategy based on the framework defined in the ground water programmatic environmental impact statement (PEIS)

  13. Radiation survey and management on the reconstructed radioactive work-site

    International Nuclear Information System (INIS)

    Yu Tao; Liang Shiqiang; Wang Youmei

    2004-12-01

    The experiences of radiation survey and administration in the prophase on reconstructed radioactive work-site are summarized. The advance works are to investigate the reconstructed work-site, settle working plans, devise inspecting flow charts, deal with something in time in the local and train the staffers. The works about prophasic decontaminating, removing and cleaning up the site have been finished, which have established the deep foundation to develop later task. (authors)

  14. Site-specific Probabilistic Analysis of DCGLs Using RESRAD Code

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jeongju; Yoon, Suk Bon; Sohn, Wook [KHNP CRI, Daejeon (Korea, Republic of)

    2016-10-15

    In general, DCGLs can be conservative (screening DCGL) if they do not take into account site specific factors. Use of such conservative DCGLs can lead to additional remediation that would not be required if the effort was made to develop site-specific DCGLs. Therefore, the objective of this work is to provide an example on the use of the RESRAD 6.0 probabilistic (site-specific) dose analysis to compare with the screening DCGL. Site release regulations state that a site will be considered acceptable for unrestricted use if the residual radioactivity that is distinguishable from background radiation results in a Total Effective Dose Equivalent (TEDE) to an average member of the critical group of less than the site release criteria, for example 0.25 mSv per year in U.S. Utilities use computer dose modeling codes to establish an acceptable level of contamination, the derived concentration guideline level (DCGL) that will meet this regulatory limit. Since the DCGL value is the principal measure of residual radioactivity, it is critical to understand the technical basis of these dose modeling codes. The objective this work was to provide example on nuclear power plant decommissioning dose analysis in a probabilistic analysis framework. The focus was on the demonstration of regulatory compliance for surface soil contamination using the RESRAD 6.0 code. Both the screening and site-specific probabilistic dose analysis methodologies were examined. Example analyses performed with the screening probabilistic dose analysis confirmed the conservatism of the NRC screening values and indicated the effectiveness of probabilistic dose analysis in reducing the conservatism in DCGL derivation.

  15. Site safety plan for Lawrence Livermore National Laboratory CERCLA investigations at site 300. Revision 2

    Energy Technology Data Exchange (ETDEWEB)

    Kilmer, J.

    1997-08-01

    Various Department of Energy Orders incorporate by reference, health and safety regulations promulgated by the Occupational Safety and Health Administration (OSHA). One of the OSHA regulations, 29 CFR 1910.120, Hazardous Waste Operations and Emergency Response, requires that site safety plans are written for activities such as those covered by work plans for Site 300 environmental investigations. Based upon available data, this Site Safety Plan (Plan) for environmental restoration has been prepared specifically for the Lawrence Livermore National Laboratory Site 300, located approximately 15 miles east of Livermore, California. As additional facts, monitoring data, or analytical data on hazards are provided, this Plan may need to be modified. It is the responsibility of the Environmental Restoration Program and Division (ERD) Site Safety Officer (SSO), with the assistance of Hazards Control, to evaluate data which may impact health and safety during these activities and to modify the Plan as appropriate. This Plan is not `cast-in-concrete.` The SSO shall have the authority, with the concurrence of Hazards Control, to institute any change to maintain health and safety protection for workers at Site 300.

  16. Preliminary site description Laxemar stage 2.1. Feedback for completion of the site investigation including input from safety assessment and repository engineering

    International Nuclear Information System (INIS)

    2006-09-01

    The Laxemar subarea is the focus for the complete site investigations in the Simpevarp area. The south and southwestern parts of the subarea (the so-called 'focused area') have been designated for focused studies during the remainder of the site investigations. This area, some 5.3 square kilometres in size, is characterised on the surface by an arc shaped body of quartz monzodiorite gently dipping to the north, flanked in the north and south by Aevroe granite. The current report documents work conducted during stage 2.1 of the site-descriptive modelling of the Laxemar subarea. The primary objective of the work performed is to provide feedback to the site investigations at Laxemar to ensure that adequate and timely data and information are obtained during the remaining investigation stage. The work has been conducted in cooperation with the site investigation team at Laxemar and representatives from safety assessment and repository engineering. The principal aim of this joint effort has been to safeguard that adequate data are collected that resolve the remaining issues/uncertainties which are of importance for repository layout and long-term safety. The proposed additional works presented in this report should be regarded as recommended additions and/or modifications in relation to the CSI programme published early 2006. The overall conclusion of the discipline-wise review of critical issues is that the CSI programme overall satisfies the demands to resolve the remaining uncertainties. This is interpreted to be partly a result of the close interaction between the site modelling team, site investigation team and the repository engineering teams, which has been in operation since early 2005. In summary, the performed interpretations and modelling have overall confirmed the version 1.2 results. The exception being Hydrogeology where the new Laxemar 2.1 borehole data suggest more favourable conditions in the south and west parts of the focused area compared with the

  17. Alternative approaches to improve site investigations

    International Nuclear Information System (INIS)

    Beach, R.B.; Silka, L.R.

    1992-01-01

    Common complaints about standard investigations at hazardous waste sites include high costs and long time frames. Investigations at military bases as part of the installation restoration program or base closures suffer additionally from nonuniformity of approach and results and redundancy of work effort conducted by multiple environmental contractors. The problems of high costs and long time frames can be minimized by the consistent use of alternative sampling methods (such as soil gas surveys) and the utilization of analytical screening procedures at both on-site and off-site laboratories. Acceptable data quality is maintained by several procedures. Incorporation of quality control measures (10 % frequency), such as matrix spikes and duplicates, into the alternative analytical techniques allows assessment of the data quality relative to predetermined data quality objectives (DQOs). Confirmation of the screening results (10% frequency) using standard US EPA methods, such as the contract laboratory program (CLP) statement of work (SOW), allows an additional evaluation of the data accuracy. Depending on the investigative objectives, knowledge based computer systems (expert systems,) could be used to improve uniformity of site evaluations. Several case histories will be presented demonstrating how soil gas surveys, screening analyses and standard analyses can be utilized to give increased site information in a reduced time frame and at a cost savings of 30 to 40%. One case history illustrates a screening technique developed by the author for polynuclear aromatics (semi-volatile organic compounds) that can be conducted at a cost savings of 90% relative to a standard US EPA method. A comparison of the phased investigative approach to one using an integrated field team is presented for fuel spill or UST areas

  18. Site Specific Waste Management Instructions for loading and shipment of category 3 investigation derived waste to ERDF

    International Nuclear Information System (INIS)

    Corriveau, C.E.; Wolf, D.M.

    1996-08-01

    This Site Specific Waste Management Instruction (SSWMI) provides guidance for management of containerized investigation-derived waste being loaded and transported to the Environmental Restoration Disposal Facility. The SSWMI outlines the waste management practices that will be performed in the field to implement federal, state, and US Department of Energy requirements. Additional guidance for waste packaging, marking, labeling and shipping is provided (US DOT rules in 49 CFR have precedence)

  19. Preliminary site description Laxemar stage 2.1. Feedback for completion of the site investigation including input from safety assessment and repository engineering

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-09-15

    The Laxemar subarea is the focus for the complete site investigations in the Simpevarp area. The south and southwestern parts of the subarea (the so-called 'focused area') have been designated for focused studies during the remainder of the site investigations. This area, some 5.3 square kilometres in size, is characterised on the surface by an arc shaped body of quartz monzodiorite gently dipping to the north, flanked in the north and south by Aevroe granite. The current report documents work conducted during stage 2.1 of the site-descriptive modelling of the Laxemar subarea. The primary objective of the work performed is to provide feedback to the site investigations at Laxemar to ensure that adequate and timely data and information are obtained during the remaining investigation stage. The work has been conducted in cooperation with the site investigation team at Laxemar and representatives from safety assessment and repository engineering. The principal aim of this joint effort has been to safeguard that adequate data are collected that resolve the remaining issues/uncertainties which are of importance for repository layout and long-term safety. The proposed additional works presented in this report should be regarded as recommended additions and/or modifications in relation to the CSI programme published early 2006. The overall conclusion of the discipline-wise review of critical issues is that the CSI programme overall satisfies the demands to resolve the remaining uncertainties. This is interpreted to be partly a result of the close interaction between the site modelling team, site investigation team and the repository engineering teams, which has been in operation since early 2005. In summary, the performed interpretations and modelling have overall confirmed the version 1.2 results. The exception being Hydrogeology where the new Laxemar 2.1 borehole data suggest more favourable conditions in the south and west parts of the focused area compared

  20. Nanoparticles for Site Specific Genome Editing

    Science.gov (United States)

    McNeer, Nicole Ali

    translate gene therapies for diseases of the blood and immune system to clinical practice. In addition, we have expanded the use of this technology to an additional nonhematopoietic model system: correction of the human cystic fibrosis transmembrane receptor gene in human bronchial epithelial cells. The work presented here represents (1) the first use of biodegradable nanoparticles for PNA delivery, (2) the first direct in vivo site-specific genome modification in human cells, and (3) the first use of triplex-PNA technology for site-specific genome editing in cystic fibrosis.

  1. Site-Specific Innovation

    DEFF Research Database (Denmark)

    Reeh, Henrik; Hemmersam, Peter

    2015-01-01

    Currently, cities across the Northern European region are actively redeveloping their former industrial harbours. Indeed, harbours areas are essential in the long-term transition from industrial to information and experience societies; harbours are becoming sites for new businesses and residences...... question is how innovation may contribute to urban life and site-specific qualities....

  2. Site-specific weed control technologies

    DEFF Research Database (Denmark)

    Christensen, Svend; Søgaard, Henning Tangen; Kudsk, Per

    2009-01-01

    Site-specific weed control technologies are defined as machinery or equipment embedded with technologies that detect weeds growing in a crop and, taking into account predefined factors such as economics, takes action to maximise the chances of successfully controlling them. In the article, we...... describe the basic parts of site specific weed control technologies, comprising of weed sensing systems, weed management models and precision weed control implements. A review of state-of-the-art technologies shows that several weed sensing systems and precision implements have been developed over the last...... of knowledge about the economic and environmental potential for increasing the resolution of weed control. The integration of site-specific information on weed distribution, weed species composition and density, and the effect on crop yield, is decisive for successful site-specific weed management.   Keywords...

  3. Corrective Action Investigation Plan for Corrective Action Unit 554: Area 23 Release Site, Nevada Test Site, Nevada

    International Nuclear Information System (INIS)

    Boehlecke, Robert F.

    2004-01-01

    This Corrective Action Investigation Plan (CAIP) contains project-specific information for conducting site investigation activities at Corrective Action Unit (CAU) 554: Area 23 Release Site, Nevada Test Site, Nevada. Information presented in this CAIP includes facility descriptions, environmental sample collection objectives, and criteria for the selection and evaluation of environmental samples. Corrective Action Unit 554 is located in Area 23 of the Nevada Test Site, which is 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 554 is comprised of one Corrective Action Site (CAS), which is: 23-02-08, USTs 23-115-1, 2, 3/Spill 530-90-002. This site consists of soil contamination resulting from a fuel release from underground storage tanks (USTs). Corrective Action Site 23-02-08 is being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives. Additional information will be obtained by conducting a corrective action investigation prior to evaluating corrective action alternatives and selecting the appropriate corrective action for this CAS. The results of the field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the Corrective Action Decision Document for CAU 554. Corrective Action Site 23-02-08 will be investigated based on the data quality objectives (DQOs) developed on July 15, 2004, by representatives of the Nevada Division of Environmental Protection; U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office; and contractor personnel. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 554. Appendix A provides a detailed discussion of the DQO methodology and the DQOs specific to CAS 23-02-08. The scope of the corrective action investigation

  4. ERDA test facilities, East Mesa Test Site. Geothermal resource investigations, Imperial Valley, California

    Energy Technology Data Exchange (ETDEWEB)

    1976-01-01

    Detailed specifications which must be complied with in the construction of the ERDA Test Facilities at the East Mesa Site for geothermal resource investigations in Imperial Valley, California are presented for use by prospective bidders for the construction contract. The principle construction work includes a 700 gpm cooling tower with its associated supports and equipment, pipelines from wells, electrical equipment, and all earthwork. (LCL)

  5. Demonstration of specific binding sites for 3H-RRR-alpha-tocopherol on human erythrocytes

    International Nuclear Information System (INIS)

    Kitabchi, A.E.; Wimalasena, J.

    1982-01-01

    Previous work from our laboratory demonstrated specific binding sites for 3 H-RRR-alpha-tocopherol ( 3 H-d alpha T) in membranes of rat adrenal cells. As tocopherol deficiency is associated with increased susceptibility of red blood cells to hemolysis, we investigated tocopherol binding sites in human RBCs. Erythrocytes were found to have specific binding sites for 3 H-d alpha T that exhibited saturability and time and cell-concentration dependence as well as reversibility of binding. Kinetic studies of binding demonstrated two binding sites--one with high affinity (Ka of 2.6 x 10(7) M-1), low capacity (7,600 sites per cell) and the other with low affinity (1.2 x 10(6) M-1), high capacity (150,000 sites per cell). In order to localize the binding sites further, RBCs were fractionated and greater than 90% of the tocopherol binding was located in the membranes. Similar to the findings in intact RBCs, the membranes exhibited two binding sites with a respective Ka of 3.3 x 10(7) M-1 and 1.5 x 10(6) M-1. Specificity data for binding demonstrated 10% binding for RRR-gamma-tocopherol, but not other tocopherol analog exhibited competition for 3 H-d alpha T binding sites. Instability data suggested a protein nature for these binding sites. Preliminary studies on Triton X-100 solubilized fractions resolved the binding sites to a major component with an Mr of 65,000 and a minor component with an Mr of 125,000. We conclude that human erythrocyte membranes contain specific binding sites for RRR-alpha-tocopherol. These sites may be of physiologic significance in the function of tocopherol on the red blood cell membrane

  6. Element-specific and site-specific ion desorption from adsorbed molecules by deep core-level photoexcitation at the K-edges

    CERN Document Server

    Baba, Y H

    2003-01-01

    This article reviews our recent works on the ion desorption from adsorbed and condensed molecules at low temperature following the core-level photoexcitations using synchrotron soft x-rays. The systems investigated here are adsorbed molecules with relatively heavy molecular weight containing third-row elements such as Si, P, S, and Cl. Compared with molecules composed of second-row elements, the highly element-specific and site-specific fragment-ion desorption were observed when we tune the photon energy at the dipole-allowed 1s -> sigma sup * (3p sup *) resonance. On the basis of the resonance Auger decay spectra around the 1s ionization thresholds, the observed highly specific ion desorption is interpreted by the localization of the excited electrons (here we call as 'spectator electrons') in the antibonding sigma sup * orbital. In order to separate the direct photo-induced process from the indirect processes triggered by the secondary electrons, the photon-stimulated ion desorption was also investigated in...

  7. Remedial Investigation of Hanford Site Releases to the Columbia River

    International Nuclear Information System (INIS)

    Lerch, J.A.

    2009-01-01

    In south-central Washington State, the Columbia River flows through the U.S. Department of Energy Hanford Site. A primary objective of the Hanford Site cleanup mission is protection of the Columbia River, through remediation of contaminated soil and groundwater that resulted from its weapons production mission. Within the Columbia River system, surface water, sediment, and biota samples related to potential Hanford Site hazardous substance releases have been collected since the start of Hanford operations. The impacts of Hanford Site hazardous substance releases to the Columbia River in areas upstream, within, and downstream of the Hanford Site boundary have been previously investigated as mandated by the U.S. Department of Energy requirements under the Atomic Energy Act. The impacts are now being assessed under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 via a remedial investigation. The Remedial Investigation Work Plan for Hanford Site Releases to the Columbia River has been developed and issued to initiate the remedial investigation. The work plan establishes a phased approach to characterize contaminants, assess current risks, and determine whether or not there is a need for any cleanup actions. Field investigation activities began in October 2008 and are anticipated to continue into Fall 2009 over a 120 mile stretch of the Columbia River. Information gained from performing this remedial investigation will ultimately be used to help make final regulatory decisions for cleaning up Hanford Site contamination that exists in and along the Columbia River. (authors)

  8. Geoscientific programme for investigation and evaluation of sites for the deep repository

    International Nuclear Information System (INIS)

    2000-08-01

    SKB's goal is to be able to commence site investigations in 2002. Extensive preparations are now being made for this transition to the next phase in the siting process for the deep repository. This report describes the investigation and evaluation programme, which is focused on a deep repository in accordance with the KBS-3 method for spent nuclear fuel. When areas for site investigations have been chosen, the programmes will be adapted to the site-specific conditions. The geoscientific work during the site investigation phase is supposed to provide the broad knowledge base that is required to evaluate the suitability of investigated sites for a deep repository. The material must be comprehensive enough to: show whether the selected site satisfies fundamental safety requirements; permit comparisons with other investigated sites; and serve as a basis for adaptation of the deep repository to the properties and characteristics of the site with an acceptable impact on society and the environment. The work is being carried out in consultation with municipalities, regulatory authorities and nearby residents. The main product of the investigations is a site description, which presents collected data and interpreted parameters that are of importance both for the overall scientific understanding of the site and for the analyses and assessments that are made of design and safety assessment with respect to the deep repository's layout and construction as well as its long-term performance and radiological safety. The site description should furthermore present an integrated description of the site (geosphere and biosphere) and its regional environs with respect to current state and naturally ongoing processes. A technical risk evaluation is carried out, by which is meant a description of uncertainties in calculations and the environmental impact of the civil engineering work. The main product of the safety assessment is a safety report, which analyzes whether long-term safety

  9. Geoscientific programme for investigation and evaluation of sites for the deep repository

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-08-01

    SKB's goal is to be able to commence site investigations in 2002. Extensive preparations are now being made for this transition to the next phase in the siting process for the deep repository. This report describes the investigation and evaluation programme, which is focused on a deep repository in accordance with the KBS-3 method for spent nuclear fuel. When areas for site investigations have been chosen, the programmes will be adapted to the site-specific conditions. The geoscientific work during the site investigation phase is supposed to provide the broad knowledge base that is required to evaluate the suitability of investigated sites for a deep repository. The material must be comprehensive enough to: show whether the selected site satisfies fundamental safety requirements; permit comparisons with other investigated sites; and serve as a basis for adaptation of the deep repository to the properties and characteristics of the site with an acceptable impact on society and the environment. The work is being carried out in consultation with municipalities, regulatory authorities and nearby residents. The main product of the investigations is a site description, which presents collected data and interpreted parameters that are of importance both for the overall scientific understanding of the site and for the analyses and assessments that are made of design and safety assessment with respect to the deep repository's layout and construction as well as its long-term performance and radiological safety. The site description should furthermore present an integrated description of the site (geosphere and biosphere) and its regional environs with respect to current state and naturally ongoing processes. A technical risk evaluation is carried out, by which is meant a description of uncertainties in calculations and the environmental impact of the civil engineering work. The main product of the safety assessment is a safety report, which analyzes whether long

  10. Remedial investigation/feasibility study work plan for the 100-FR-3 operable unit, Hanford Site, Richland, Washington

    International Nuclear Information System (INIS)

    1992-09-01

    Four areas of the Hanford Site (the 100, 200, 300, and 1100 Areas) have been included on the US Environmental Protection Agency's (EPA's) National Priorities List (NPL) under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). Figure 1-1 shows the location of these areas. Under the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement, Ecology et al. 1990a), signed by the Washington State Department of Ecology (Ecology), EPA, and the US Department of Energy (DOE), more than 1,000 inactive waste disposal and unplanned release sites on the Hanford Site have been grouped into a number of source and groundwater operable units. These operable units contain contamination in the form of hazardous waste, radioactive/hazardous mixed waste, and other CERCLA hazardous substances. This work plan and the attached supporting project plans establish the operable unit setting and the objectives, procedures, tasks, and schedule for conducting the CERCLA remedial investigation/feasibility study (RI/FS) for the 100-FR-3 operable unit. The 100-K Area consists of the 100-FR-3 groundwater operable unit and two source operable units. The 100-FR-3 operable unit includes all contamination found in the aquifer soils and water beneath the 100-F Area. Source operable units include facilities and unplanned release sites that are potential sources of contamination. A separate work plan has been initiated for the 100-FR-1 source operable unit (DOE-RL 1992a)

  11. Remedial investigation/feasibility study work plan for the 100-FR-1 operable unit, Hanford Site, Richland, Washington

    International Nuclear Information System (INIS)

    1992-08-01

    Four areas of the Hanford Site (the 100, 200,300, and 1100 Areas) have been included on the US Environmental Protection Agency's (EPA's) National Priorities List (NPL) under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). Under the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement, Ecology et al. 1990a), signed by the Washington State Department of Ecology (Ecology), EPA, and the US Department of Energy (DOE), more than 1,000 inactive waste disposal and unplanned release sites on the Hanford Site have been grouped into a number of source and groundwater operable units. These operable units contain contamination in the form of hazardous waste, radioactive/hazardous mixed waste, and other CERCLA hazardous substances. This work plan and the attached supporting project plans establish the objectives, procedures, tasks, and schedule for conducting the CERCLA remedial investigation/feasibility study (RI/FS) for the 100-FR-1 operable unit. The 100-FR-1 source operable unit is one of two source operable units in the 100-F Area. Source operable units include facilities and unplanned release sites that are potential sources of hazardous substance contamination. The groundwater affected or potentially affected by the entire 100-F Area is considered as a separate operable unit, the 100-FR-3 groundwater operable unit. A separate work plan has been initiated for the 100-FR-3 operable unit (DOE/RL 1992a)

  12. Final disposal of spent fuel in the Finnish bedrock. Scope and requirements for site-specific safety analysis

    International Nuclear Information System (INIS)

    1996-12-01

    The report is a summary of the research conducted in the period 1993 to 1996 into safety of spent fuel final disposal. The principal goal of the research in this period, as set in 1993, was to develop a strategy for site-specific safety analysis. At the same time efforts were to be continued to gather data and validate the technical approach for the analysis. The work aimed at having the data needed for the analysis available at the end of year 1998. A safety assessment update, TILA-96, prepared by VTT Energy, is published as a separate report. The assessment is based on the TVO-92 safety analysis, but takes into account the knowledge acquired after 1992 on safety aspects of the disposal system and the data gathered from the site investigations made by TVO and from the beginning of 1996, by Posiva. Since the site investigations are still ongoing and much of the data gathered still pending interpretation, only limited amount of new site-specific information has been available for the present assessment. (172 refs.)

  13. Remedial investigation/feasibility study work plan for the 100-BC-5 operable unit, Hanford Site, Richland, Washington

    International Nuclear Information System (INIS)

    1992-07-01

    Four areas of the Hanford Site (the 100, 200, 300, and 1100 Areas) have been included on the US Environmental Protection Agency's (EPA's) National Priorities List (NPL) under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). The Tri-Party Agreement requires that the cleanup programs at the Hanford Site integrate the requirements of CERCLA, RCRA, and Washington State's dangerous waste (the state's RCRA-equivalent) program. This work plan and the attached supporting project plans establish the operable unit setting and the objectives, procedures, tasks, and schedule for conducting the CERCLA remedial investigation/feasibility study (RI/FS) for the 100-BC-5 operable unit. The 100-B/C Area consists of the 100-BC-5 groundwater operable unit and four source operable units. The 100-BC-5 operable unit includes all contamination found in the aquifer soils and water beneath the 100-B/C Area. Source operable units include facilities and unplanned release sites that are potential sources of contamination

  14. Site observational work plan for the UMTRA Project site at Monument Valley, Arizona

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-03-01

    The site observational work plan (SOWP) for the Monument Valley, Arizona, US Department of Energy (DOE) Uranium Mill Tailings Remedial Action(UMTRA) Project site is one of the first site-specific documents developed to achieve ground water compliance at the site. This SOWP applies information about the Monument Valley site to a regulatory compliance framework that identifies strategies that could be used to meet ground water compliance. The compliance framework was developed in the UMTRA Ground Water programmatic environmental impact statement (DOE, 1996). The DOE`s goal is to implement a cost-effective site strategy that complies with the US Environmental Protection Agency (EPA) ground water standards and protects human health and the environment. The compliance strategy that emerges in the final version of the SOWP will be evaluated in the site-specific environmental assessment to determine potential environmental impacts and provide stakeholders a forum for review and comment. When the compliance strategy is acceptable, it will be detailed in a remedial action plan that will be subject to review by the state and/or tribe and concurrence by the US Nuclear Regulatory Commission (NRC). Information for the preparation of this SOWP indicates active remediation is the most likely compliance strategy for the Monument Valley site. Additional data are needed to determine the most effective remediation technology.

  15. Site observational work plan for the UMTRA Project site at Monument Valley, Arizona

    International Nuclear Information System (INIS)

    1996-03-01

    The site observational work plan (SOWP) for the Monument Valley, Arizona, US Department of Energy (DOE) Uranium Mill Tailings Remedial Action(UMTRA) Project site is one of the first site-specific documents developed to achieve ground water compliance at the site. This SOWP applies information about the Monument Valley site to a regulatory compliance framework that identifies strategies that could be used to meet ground water compliance. The compliance framework was developed in the UMTRA Ground Water programmatic environmental impact statement (DOE, 1996). The DOE's goal is to implement a cost-effective site strategy that complies with the US Environmental Protection Agency (EPA) ground water standards and protects human health and the environment. The compliance strategy that emerges in the final version of the SOWP will be evaluated in the site-specific environmental assessment to determine potential environmental impacts and provide stakeholders a forum for review and comment. When the compliance strategy is acceptable, it will be detailed in a remedial action plan that will be subject to review by the state and/or tribe and concurrence by the US Nuclear Regulatory Commission (NRC). Information for the preparation of this SOWP indicates active remediation is the most likely compliance strategy for the Monument Valley site. Additional data are needed to determine the most effective remediation technology

  16. Preliminary safety evaluation for the Laxemar subarea. Based on data and site descriptions after the initial site investigation stage

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, Johan [JA Streamflow AB, Aelvsjoe (Sweden)

    2006-03-15

    The main objectives of this Preliminary Safety Evaluation (PSE) of the Laxemar subarea have been to determine, with limited efforts, whether the feasibility study's judgement of the suitability of the candidate area with respect to long-term safety holds up in the light of the actual site investigation data; to provide feedback to continued site investigations and site-specific repository design and to identify site-specific scenarios and geoscientific issues for further analyses. The PSE focuses on comparing the attained knowledge of the sites with the suitability criteria as set out by SKB in 2000. These criteria both concern properties of the site judged to be necessary for safety and engineering (requirements) and properties judged to be beneficial (preferences). The findings are then evaluated in order to provide feedback to continued investigations and design work. The PSE does not aim at comparing sites and does not assess compliance with safety and radiation protection criteria. The latter is eventually done in coming Safety Assessments. This preliminary safety evaluation shows that, according to existing data, the Laxemar subarea meets all safety requirements. The evaluation also shows that the Laxemar subarea meets most of the safety preferences, but for some aspects of the site description further reduction of the uncertainties would enhance the safety case. Despite the stated concerns, there is no reason, from a safety point of view, not to continue the Site Investigations at the Laxemar subarea. There are uncertainties to resolve and the safety would eventually need to be verified through a proper safety assessment. Only some of the uncertainties noted in the Site Descriptive Model have safety implications and need further resolution for this reason. Furthermore, uncertainties may need resolving for other reasons, such as giving an adequate assurance of site understanding or assisting in optimising design. Notably, there are questions about the

  17. Preliminary safety evaluation for the Laxemar subarea. Based on data and site descriptions after the initial site investigation stage

    International Nuclear Information System (INIS)

    Andersson, Johan

    2006-03-01

    The main objectives of this Preliminary Safety Evaluation (PSE) of the Laxemar subarea have been to determine, with limited efforts, whether the feasibility study's judgement of the suitability of the candidate area with respect to long-term safety holds up in the light of the actual site investigation data; to provide feedback to continued site investigations and site-specific repository design and to identify site-specific scenarios and geoscientific issues for further analyses. The PSE focuses on comparing the attained knowledge of the sites with the suitability criteria as set out by SKB in 2000. These criteria both concern properties of the site judged to be necessary for safety and engineering (requirements) and properties judged to be beneficial (preferences). The findings are then evaluated in order to provide feedback to continued investigations and design work. The PSE does not aim at comparing sites and does not assess compliance with safety and radiation protection criteria. The latter is eventually done in coming Safety Assessments. This preliminary safety evaluation shows that, according to existing data, the Laxemar subarea meets all safety requirements. The evaluation also shows that the Laxemar subarea meets most of the safety preferences, but for some aspects of the site description further reduction of the uncertainties would enhance the safety case. Despite the stated concerns, there is no reason, from a safety point of view, not to continue the Site Investigations at the Laxemar subarea. There are uncertainties to resolve and the safety would eventually need to be verified through a proper safety assessment. Only some of the uncertainties noted in the Site Descriptive Model have safety implications and need further resolution for this reason. Furthermore, uncertainties may need resolving for other reasons, such as giving an adequate assurance of site understanding or assisting in optimising design. Notably, there are questions about the

  18. Identifying protein phosphorylation sites with kinase substrate specificity on human viruses.

    Directory of Open Access Journals (Sweden)

    Neil Arvin Bretaña

    Full Text Available Viruses infect humans and progress inside the body leading to various diseases and complications. The phosphorylation of viral proteins catalyzed by host kinases plays crucial regulatory roles in enhancing replication and inhibition of normal host-cell functions. Due to its biological importance, there is a desire to identify the protein phosphorylation sites on human viruses. However, the use of mass spectrometry-based experiments is proven to be expensive and labor-intensive. Furthermore, previous studies which have identified phosphorylation sites in human viruses do not include the investigation of the responsible kinases. Thus, we are motivated to propose a new method to identify protein phosphorylation sites with its kinase substrate specificity on human viruses. The experimentally verified phosphorylation data were extracted from virPTM--a database containing 301 experimentally verified phosphorylation data on 104 human kinase-phosphorylated virus proteins. In an attempt to investigate kinase substrate specificities in viral protein phosphorylation sites, maximal dependence decomposition (MDD is employed to cluster a large set of phosphorylation data into subgroups containing significantly conserved motifs. The experimental human phosphorylation sites are collected from Phospho.ELM, grouped according to its kinase annotation, and compared with the virus MDD clusters. This investigation identifies human kinases such as CK2, PKB, CDK, and MAPK as potential kinases for catalyzing virus protein substrates as confirmed by published literature. Profile hidden Markov model is then applied to learn a predictive model for each subgroup. A five-fold cross validation evaluation on the MDD-clustered HMMs yields an average accuracy of 84.93% for Serine, and 78.05% for Threonine. Furthermore, an independent testing data collected from UniProtKB and Phospho.ELM is used to make a comparison of predictive performance on three popular kinase-specific

  19. Identifying protein phosphorylation sites with kinase substrate specificity on human viruses.

    Science.gov (United States)

    Bretaña, Neil Arvin; Lu, Cheng-Tsung; Chiang, Chiu-Yun; Su, Min-Gang; Huang, Kai-Yao; Lee, Tzong-Yi; Weng, Shun-Long

    2012-01-01

    Viruses infect humans and progress inside the body leading to various diseases and complications. The phosphorylation of viral proteins catalyzed by host kinases plays crucial regulatory roles in enhancing replication and inhibition of normal host-cell functions. Due to its biological importance, there is a desire to identify the protein phosphorylation sites on human viruses. However, the use of mass spectrometry-based experiments is proven to be expensive and labor-intensive. Furthermore, previous studies which have identified phosphorylation sites in human viruses do not include the investigation of the responsible kinases. Thus, we are motivated to propose a new method to identify protein phosphorylation sites with its kinase substrate specificity on human viruses. The experimentally verified phosphorylation data were extracted from virPTM--a database containing 301 experimentally verified phosphorylation data on 104 human kinase-phosphorylated virus proteins. In an attempt to investigate kinase substrate specificities in viral protein phosphorylation sites, maximal dependence decomposition (MDD) is employed to cluster a large set of phosphorylation data into subgroups containing significantly conserved motifs. The experimental human phosphorylation sites are collected from Phospho.ELM, grouped according to its kinase annotation, and compared with the virus MDD clusters. This investigation identifies human kinases such as CK2, PKB, CDK, and MAPK as potential kinases for catalyzing virus protein substrates as confirmed by published literature. Profile hidden Markov model is then applied to learn a predictive model for each subgroup. A five-fold cross validation evaluation on the MDD-clustered HMMs yields an average accuracy of 84.93% for Serine, and 78.05% for Threonine. Furthermore, an independent testing data collected from UniProtKB and Phospho.ELM is used to make a comparison of predictive performance on three popular kinase-specific phosphorylation site

  20. Millennials at Work: Investigating the Specificity of Generation Y versus Other Generations

    Directory of Open Access Journals (Sweden)

    Florina PÎNZARU

    2016-06-01

    Full Text Available The present study intends to discuss the psychological profile of Generation Y versus other generations.The differences between Millennials and other generations are addressed in terms of values, personality characteristics, and reactions under stress. The topicality and relevance of the research theme are supported by the fact that most of the people who are currently employed in companies all over the world are members of the Generation Y. This situation requires a proper investigation of the characteristics and specificity of the so-called Millennials with a view to provide organizations with pertinent inputs for designing well-informed policies and for smoothly integrating Millennials in the workplace. To this end, Hogan Assessments personality inventories were applied online to more than 1000 persons from Generation Y (up to 29 years old and more than 3000 persons from other generations (above 29 years old. Among others, the findings show that Millennials are motivated by recognition, public acknowledgment, instant and frequent positive feedback and gratification. As they need balance between personal and professional life, as well as a comfortable environment, they require a flexible work schedule, resent staying after hours. Being motivated to become part of various social networks, work in various teams, Millennials are able to easily find satisfaction in missions that involve interactions with new persons coming from different cultures and geographical areas. They are motivated by work in a nonconformist environment without strict rules and traditional work approaches, they tend to challenge the status quo and they will not be patient to keep the same job many years.

  1. Remedial investigation/feasibility study work plan for the 100-KR-4 operable unit, Hanford Site, Richland, Washington

    International Nuclear Information System (INIS)

    1992-09-01

    Four areas of the Hanford Site (the 100, 200, 300, and 1100 Areas) have been included on the US Environmental Protection Agency's (EPA's) National Priorities List (NPL) under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). This work plan and the attached supporting project plans establish the operable unit setting and the objectives, procedures, tasks, and schedule for conducting the CERCLA remedial investigation/feasibility study (RI/FS) for the 100-KR-4 operable unit. The 100-K Area consists of the 100-KR-4 groundwater operable unit and three source operable units. The 100-KR-4 operable unit includes all contamination found in the aquifer soils and water beneath the 100-K Area. Source operable units include facilities and unplanned release sites that are potential sources of contamination

  2. Remedial investigation/feasibility study work plan for the 100-KR-4 operable unit, Hanford Site, Richland, Washington

    Energy Technology Data Exchange (ETDEWEB)

    1992-09-01

    Four areas of the Hanford Site (the 100, 200, 300, and 1100 Areas) have been included on the US Environmental Protection Agency`s (EPA`s) National Priorities List (NPL) under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). This work plan and the attached supporting project plans establish the operable unit setting and the objectives, procedures, tasks, and schedule for conducting the CERCLA remedial investigation/feasibility study (RI/FS) for the 100-KR-4 operable unit. The 100-K Area consists of the 100-KR-4 groundwater operable unit and three source operable units. The 100-KR-4 operable unit includes all contamination found in the aquifer soils and water beneath the 100-K Area. Source operable units include facilities and unplanned release sites that are potential sources of contamination.

  3. Geological and geotechnical investigations for nuclear power plants sites

    International Nuclear Information System (INIS)

    Alves, P.R.R.

    1984-09-01

    This dissertation presents a general methodology for the tasks of geological and geotechnical investigations, to be performed in the proposed sites for construction of nuclear Power Plants. In this work, items dealing with the standards applied to licensing of Nuclear Power Plants, with the selection process of sites and identification of geological and geotechnical parameters needed for the regional and local characterization of the area being studied, were incorporated. This dissertation also provides an aid to the writing of Technical Reports, which are part of the documentation an owner of a Nuclear Power Plant needs to submit to the Comissao Nacional de Energia Nuclear, to fulfill the nuclear installation licensing requirements. Moreover, this work can contribute to the planning of field and laboratory studies, needed to determine the parameters of the area under investigation, for the siting of Nuclear Power Plants. (Author) [pt

  4. The Application of TAPM for Site Specific Wind Energy Forecasting

    Directory of Open Access Journals (Sweden)

    Merlinde Kay

    2016-02-01

    Full Text Available The energy industry uses weather forecasts for determining future electricity demand variations due to the impact of weather, e.g., temperature and precipitation. However, as a greater component of electricity generation comes from intermittent renewable sources such as wind and solar, weather forecasting techniques need to now also focus on predicting renewable energy supply, which means adapting our prediction models to these site specific resources. This work assesses the performance of The Air Pollution Model (TAPM, and demonstrates that significant improvements can be made to only wind speed forecasts from a mesoscale Numerical Weather Prediction (NWP model. For this study, a wind farm site situated in North-west Tasmania, Australia was investigated. I present an analysis of the accuracy of hourly NWP and bias corrected wind speed forecasts over 12 months spanning 2005. This extensive time frame allows an in-depth analysis of various wind speed regimes of importance for wind-farm operation, as well as extreme weather risk scenarios. A further correction is made to the basic bias correction to improve the forecast accuracy further, that makes use of real-time wind-turbine data and a smoothing function to correct for timing-related issues. With full correction applied, a reduction in the error in the magnitude of the wind speed by as much as 50% for “hour ahead” forecasts specific to the wind-farm site has been obtained.

  5. Ecological risk assessment guidance for preparation of remedial investigation/feasibility study work plans

    International Nuclear Information System (INIS)

    Pentecost, E.D.; Vinikour, W.S.

    1993-08-01

    This guidance document (1) provides instructions on preparing the components of an ecological work plan to complement the overall site remedial assessment investigation/feasibility study (RI/FS) work plan and (2) directs the user on how to implement ecological tasks identified in the plan. Under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA), as amended by the Superfired Amendments and Reauthorization Act of 1986 (SARA), an RI/FS work plan win have to be developed as part of the site-remediation scoping the process. Specific guidance on the RI/FS process and the preparation of work plans has been developed by the US Environmental Protection Agency (EPA 1988a). This document provides guidance to US Department of Energy (DOE) staff and contractor personnel for incorporation of ecological information into environmental remediation planning and decision making at CERCLA sites. An overview analysis of early ecological risk assessment methods (i.e., in the 1980s) at Superfund sites was conducted by the EPA (1989a). That review provided a perspective of attention given to ecological issues in some of the first RI/FS studies. By itself, that reference is of somewhat limited value; it does, however, establish a basis for comparison of past practices in ecological risk with current, more refined methods

  6. [Organising an investigation site: a national training reference document].

    Science.gov (United States)

    Cornu, Catherine; David, Frédérique; Duchossoy, Luc; Hansel-Esteller, Sylvie; Bertoye, Pierre-Henri; Giacomino, Alain; Mouly, Stéphane; Diebolt, Vincent; Blazejewski, Sylvie

    2014-01-01

    Several surveys have shown a declining performance of French investigators in conducting clinical trials. This is partly due to insufficient and heterogeneous investigator training and site organisation. A multidisciplinary group was set up to propose solutions. We describe the tools developed to improve study site organisation. This working group was made up of clinical research experts from academia, industry, drug regulatory authorities, general practice, and consulting. Methods and tools were developed to improve site organisation. The proposed tools mainly focus on increasing investigators' awareness of their responsibilities, their research environment, the importance of a thorough feasibility analysis, and the implementation of active patient recruitment strategies. These tools should be able to improve site organisation and performances in conducting clinical trials. © 2014 Société Française de Pharmacologie et de Thérapeutique.

  7. Demand-specific work ability, poor health and working conditions in middle-aged full-time employees

    DEFF Research Database (Denmark)

    Nabe-Nielsen, Kirsten; Thielen, Karsten; Nygaard, Else

    2014-01-01

    -sectional questionnaire data from 3381 full-time employees responding to questions about vocational education, job demands and social support (working conditions), musculoskeletal pain (MSP) and major depression (MD) (poor health) and seven questions about difficulty managing different job demands (reduced demand......We investigated the prevalence of reduced demand-specific work ability, its association with age, gender, education, poor health, and working conditions, and the interaction between poor health and working conditions regarding reduced demand-specific work ability. We used cross...... was associated with six measures of reduced demand-specific work ability. We found no interaction between working conditions and poor health regarding reduced demand-specific work ability....

  8. Work site stress management: national survey results.

    Science.gov (United States)

    Fielding, J E

    1989-12-01

    The National Survey of Work Site Health Promotion Activities established baseline data on the frequency of nine types of health promotion activity at private work sites with more than 50 employees in the United States. Stress management activities were provided at 26.6% of work sites. Types of activities at those work sites with some stress management activity included group counseling (58.5%), individual counseling (39.3%), follow-up counseling (25.9%), special events (11.5%), providing information about stress (80.7%), providing a place to relax (64.8%), and making organizational changes to reduce employee stress (81.2%). Frequency of activities varied by industry type and by region of the country. Incidence of most types of activities did not increase as work site size increased, although the likelihood of having any of these activities did increase with work site size. Stress management activities were more likely to be present at work sites with a medical staff or health educator. An increase in output, productivity, or quality was the most frequently cited benefit (46.5%). Negative effects were reported at 2.6% of the work sites. Other health promotion activities found at the work sites surveyed included smoking cessation (61.8%), treatment and control of high blood pressure (36.7%), and weight control (34.7%). Employee Assistance Programs were responsible for stress management at 62% of the work sites with an Employee Assistance Program.

  9. Final Phase II report : QuickSite(R) investigation, Everest, Kansas.

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, L. M. (Environmental Research)

    2003-11-01

    this reason, the CCC/USDA is conducting an environmental site investigation to determine the source(s) and extent of the carbon tetrachloride contamination at Everest and to assess whether the contamination requires remedial action. The investigation at Everest is being performed by the Environmental Research Division of Argonne National Laboratory. Argonne is a nonprofit, multidisciplinary research center operated by the University of Chicago for the U.S. Department of Energy (DOE). The CCC/USDA has entered into an interagency agreement with DOE, under which Argonne provides technical assistance to the CCC/USDA with environmental site characterization and remediation at its former grain storage facilities. At these facilities, Argonne is applying its QuickSite{reg_sign} environmental site characterization methodology. This methodology has been applied successfully at a number of former CCC/USDA facilities in Kansas and Nebraska and has been adopted by the American Society for Testing and Materials (ASTM 1998) as standard practice for environmental site characterization. Phase I of the QuickSite{reg_sign} investigation examined the key geologic, hydrogeologic, and hydrogeochemical relationships that define potential contaminant migration pathways at Everest (Argonne 2001). Phase II of the QuickSite{reg_sign} investigation at Everest was undertaken with the primary goal of delineating and improving understanding of the distribution of carbon tetrachloride contamination in groundwater at this site and the potential source area(s) that might have contributed to this contamination. To address this goal, four specific technical objectives were developed to guide the Phase II field studies. Sampling of near-surface soils at the former Everest CCC/USDA facility that was originally planned for Phase I had to be postponed until October 2000 because of access restrictions. Viable vegetation was not available for sampling then. This period is termed the first session of Phase II

  10. Work plan for monitor well installation water and sediment sample collection aquifer testing and topographic surveying at the Riverton, Wyoming, UMTRA Project Site

    International Nuclear Information System (INIS)

    1995-06-01

    Investigations conducted during preparation of the site observational work plan (SOWP) at the Uranium Mill Tailings Remedial Action (UMTRA) Project site support a proposed natural flushing ground water compliance strategy, with institutional controls. However, additional site-specific data are needed to reduce uncertainties in order to confirm the applicability and feasibility of this proposed compliance strategy option. This proposed strategy will be analyzed in the site-specific environmental assessment. The purpose of this work plan is to summarize the data collection objectives to fill those data needs, describe the data collection activities that will be undertaken to meet those objectives, and elaborate on the data quality objectives which define the procedures that will be followed to ensure that the quality of these data meet UMTRA Project needs

  11. Realities of site investigation

    International Nuclear Information System (INIS)

    Beauheim, R.; Ben Benfahel, M.; Byrum, Ch.; Fedor, F.; Geier, J.; Nys, V.; Schelkes, K.; Selroos, J.O.; Szucs, I.; Whittaker, St.

    2007-01-01

    During the working session, Working Group C discussed the following questions proposed by the Scientific Programme Committee of AMIGO 2: - Provide a list of concrete examples of limitations and their reasons. In addressing these issues, consider the relation between what you can measure and what you would like to describe. - Can these limitations be handled by defensible uncertainty descriptions? - What has been your experience in predicting properties/responses and then making comparisons with subsequent measurements? How much 'after-fitting' was necessary? Did the exercise contribute to validation? What did it teach you about your abilities to characterise? - What are the realities of transferability of data between sites? What can actually be transferred (data, conceptual models, evaluation procedures) and what could not? - How have the experiences on possibilities and limitations influenced your investigation programme? - How are the limits in what can be achieved factored into safety assessment and engineering? (authors)

  12. Work plan for preliminary investigation of organic constituents in ground water at the New Rifle site, Rifle, Colorado. Revision 2

    International Nuclear Information System (INIS)

    1996-01-01

    A special study screening for Appendix 9 (40 CFR Part 264) analytes identified the New Rifle site as a target for additional screening for organic constituents. Because of this recommendation and the findings in a recent independent technical review, the US Department of Energy (DOE) has requested that the Technical Assistance Contractor (TAC) perform a preliminary investigation of the potential presence of organic compounds in the ground water at the New Rifle Uranium Mill Tailings Remedial Action (UMTRA) Project site, Rifle, Colorado. From 1958 to 1972, organic chemicals were used in large quantities during ore processing at the New Rifle site, and it is possible that some fraction was released to the environment. Therefore, the primary objective of this investigation is to determine whether organic chemicals used at the milling facility are present in the ground water. The purpose of this document is to describe the work that will be performed and the procedures that will be followed during installation of ground water well points at the New Rifle site. The selection of analytes and the procedures for collecting ground water samples for analysis of organic constituents are also described

  13. Demand-specific work ability, poor health and working conditions in middle-aged full-time employees.

    Science.gov (United States)

    Nabe-Nielsen, Kirsten; Thielen, Karsten; Nygaard, Else; Thorsen, Sannie Vester; Diderichsen, Finn

    2014-07-01

    We investigated the prevalence of reduced demand-specific work ability, its association with age, gender, education, poor health, and working conditions, and the interaction between poor health and working conditions regarding reduced demand-specific work ability. We used cross-sectional questionnaire data from 3381 full-time employees responding to questions about vocational education, job demands and social support (working conditions), musculoskeletal pain (MSP) and major depression (MD) (poor health) and seven questions about difficulty managing different job demands (reduced demand-specific work ability). Reduced demand-specific work ability varied from 9% to 19% among the 46-year old and from 11% to 21% among the 56-year old. Age was associated with two, gender with four, and education with all measures of reduced demand-specific work ability. MSP was associated with four and MD was associated with six measures of reduced demand-specific work ability. We found no interaction between working conditions and poor health regarding reduced demand-specific work ability. Copyright © 2014 Elsevier Ltd and The Ergonomics Society. All rights reserved.

  14. 29 CFR 1926.752 - Site layout, site-specific erection plan and construction sequence.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 8 2010-07-01 2010-07-01 false Site layout, site-specific erection plan and construction... Steel Erection § 1926.752 Site layout, site-specific erection plan and construction sequence. (a... strength or sufficient strength to support the loads imposed during steel erection. (c) Site layout. The...

  15. Work-related injuries and fatalities in the geotechnical site works.

    Science.gov (United States)

    Akboğa Kale, Özge; Eskişar, Tuğba

    2018-05-19

    Geotechnical site works are comprehensive, and they constitute the first step of the construction process. This study performs data mining of geotechnical works and analyzes the database for the root causes of accidents. The Occupational Safety and Health Administration (OSHA) was chosen for the 1984-2013 time frame with 247 cases. Descriptive statistical analyses were performed to discuss variables such as the end use of the work, project type and cost, soil type and condition, type and degree of injury, cause and type of accident, unsafe acts, and occupation and union status of the victim. The results showed that these accidents have a high frequency of recurrence and have a high severity level (54.3% fatalities). In addition, a total of 838 violations were recorded with penalties reaching 5 million US dollars. This study emphasizes that project-specific countermeasures should be taken regarding the root causes of accidents, leading to vigorous strategies to develop safety measures.

  16. Site Specific Vendor's License

    Data.gov (United States)

    Montgomery County of Maryland — This dataset contains information of a site-specific vendor's license which is required if an individual sells or offers to sell goods or services from a stationary...

  17. Site observational work plan for the UMTRA Project site at Riverton, Wyoming

    International Nuclear Information System (INIS)

    1994-09-01

    The site observational work plan (SOWP) for the Riverton, Wyoming, Uranium Mill Tailings Remedial Action (UMTRA) Project Site is the first document for the UMTRA Ground Water Project to address site-specific activities to meet compliance with the U.S. Environmental Protection Agency (EPA) proposed ground water standards (52 FR 36000 (1987)). In support of the activities the regulatory framework and drivers are presented along with a discussion of the relationship of this SOWP to other UMTRA Ground Water Project programmatic documents. A combination of the two compliance strategies that will be recommended for this site are no remediation with the application of alternate concentration levels (ACL) and natural flushing in conjunction with institutional controls. ACLs are to be applied to constituents that occur at concentrations above background levels but which are essential nutrients and occur within nutritional ranges and/or have very low toxicity and high dietary intake rates compared to the levels detected in the ground water. The essential premise of natural flushing is that ground water movement and natural attenuation processes will reduce the detected contamination to background levels within 1 00 years. These two recommended compliance strategies were evaluated by applying Riverton site-specific data to the compliance framework developed in the UMTRA Ground Water programmatic environmental impact statement. There are three aquifers beneath the site: a surficial unconfined aquifer, a middle semiconfined aquifer, and a deeper confined aquifer. The milling-related contamination at the site has affected both the surficial and semiconfined aquifers, although the leaky shale aquifers separating these units limits the downward migration of contamination into the semiconfined aquifer. A shale aquitard separates the semiconfined aquifer from the underlying confined aquifer which has not been contaminated by milling-related constituents

  18. Unveiled: Interrogating the Use of Applied Drama in Multiple and Specific Sites

    Science.gov (United States)

    Daboo, Jerri

    2007-01-01

    This article examines a view of site through postcolonial feminism to suggest that multiple and contradictory discourses of culture, location, gender and context are all vital in an understanding of a specific site when working with a community. These views are applied to a project undertaken with a group of Asian women in Britain exploring issues…

  19. Site-Specific Atmospheric Dispersion Characteristics of Korean Nuclear Power Plant Sites

    International Nuclear Information System (INIS)

    Han, M. H.; Kim, E. H.; Suh, K. S.; Hwang, W. T.; Choi, Y. G.

    2001-01-01

    Site-specific atmospheric dispersion characteristics have been analyzed. The northwest and the southwest wind prevail on nuclear sites of Korea. The annual isobaric surface averaged for twenty years around Korean peninsula shows that west wind prevails. The prevailing west wind is profitable in the viewpoint of radiation protection because three of four nuclear sites are located in the east side. Large scale field tracer experiments over nuclear sites have been conducted for the purpose of analyzing the atmospheric dispersion characteristics and validating a real-time atmospheric dispersion and dose assessment system FADAS. To analyze the site-specific atmospheric dispersion characteristics is essential for making effective countermeasures against a nuclear emergency

  20. RCRA facility investigation/corrective measures study work plan for the 100-HR-1 operable unit, Hanford Site, Richland, Washington

    International Nuclear Information System (INIS)

    1992-09-01

    Four areas of the Hanford Site (the 100, 200, 300, and 1100 Areas) have been included on the US. Environmental Protection Agency's (EPA's) National Priorities List (NPL) under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). Under the Hanford Federal Facility Agreement and Consent Order, signed by the Washington State Department of Ecology (Ecology), EPA, and the US Department of Energy (DOE), more than 1,000 inactive waste disposal and unplanned release sites on the Hanford Site have been grouped into a number of source and groundwater operable units. These operable units contain contamination in the form of hazardous waste, radioactive/hazardous mixed waste, and other CERCLA hazardous substances. This work plan and the attached supporting project plans establish the operable unit setting and the objectives, procedures, tasks, and schedule for conducting the RCRA facility investigation/corrective measures study (RFI/CMS) for the 100-HR-1 source operable unit. Source operable units include facilities and unplanned release sites that are potential sources of contamination. The 100-HR-3 operable unit underlies the D/DR and H Areas, the 600 Area between them, and the six source operable units these areas contain. The 100-HR-3 operable unit includes all contamination found in the aquifer soils and water within its boundary. Separate work plans have been initiated for the 100-HR-3 groundwater operable unit (DOE-RL 1992a) and the 100-DR-1 (DOE-RL 1992b) source operable units

  1. Statistical and Economic Techniques for Site-specific Nematode Management.

    Science.gov (United States)

    Liu, Zheng; Griffin, Terry; Kirkpatrick, Terrence L

    2014-03-01

    Recent advances in precision agriculture technologies and spatial statistics allow realistic, site-specific estimation of nematode damage to field crops and provide a platform for the site-specific delivery of nematicides within individual fields. This paper reviews the spatial statistical techniques that model correlations among neighboring observations and develop a spatial economic analysis to determine the potential of site-specific nematicide application. The spatial econometric methodology applied in the context of site-specific crop yield response contributes to closing the gap between data analysis and realistic site-specific nematicide recommendations and helps to provide a practical method of site-specifically controlling nematodes.

  2. Site-Specific Seismic Site Response Model for the Waste Treatment Plant, Hanford, Washington

    Energy Technology Data Exchange (ETDEWEB)

    Rohay, Alan C.; Reidel, Steve P.

    2005-02-24

    This interim report documents the collection of site-specific geologic and geophysical data characterizing the Waste Treatment Plant site and the modeling of the site-specific structure response to earthquake ground motions.

  3. Oskarshamn site investigation. Programme for further investigations of bedrock, soil, water and environment in Laxemar subarea

    International Nuclear Information System (INIS)

    2006-03-01

    SKB (the Swedish Nuclear Fuel and Waste Management Co), has been conducting a site investigation at Simpevarp and Laxemar in Oskarshamn for siting of a final repository for spent nuclear fuel. An equivalent investigation is being conducted in Forsmark in Ohmmeter's. The initial part of the site investigations had been completed for the both of the subareas Simpevarp and Laxemar in the autumn of 2004. Based on the results of these investigations, SKB preliminarily prioritized the Laxemar subarea for further investigations. A programme was presented for the first stage of the complete site investigation in the Laxemar subarea, along with the main features of the remainder of the site investigation. The programme included investigations up until the summer of 2005 and was particularly aimed at obtaining answers to several vital questions so that the subsequent investigations could be focused on the rock areas judged to be most suitable for a final repository. These investigations have now been completed. This report presents the programme for the remainder of the site investigation. The points of departure are the general goals for the Deep Repository Project during the site investigation phase, analyses and evaluations of data from completed investigations, and the needs for additional data to be able to evaluate the site as a siting alternative for the final repository. The account mainly covers the investigations on the site. All other work - analyses, site descriptive modelling, facility design, safety assessments and studies and assessments of consequences for the environment, human health and society - are only mentioned to the extent necessary in order to place the investigations in their context. The direction of the site investigation in Oskarshamn and the investigation programme presented in this report is based on SKB's preliminary decision to prioritize the Laxemar subarea for further investigations. A final decision on the direction of the site

  4. Site observational work plan for the UMTRA project site at Shiprock, New Mexico

    International Nuclear Information System (INIS)

    1994-09-01

    The site observational work plan (SOWP) for the Shiprock, New Mexico, Uranium Mill Tailings Remedial Action (UMTRA) Project Site is the initial document for developing site-specific activities to achieve regulatory compliance in the UMTRA Ground Water Project. The regulatory framework used to select the proposed ground water compliance strategies is presented along with a discussion of the relationship of this SOWP to other UMTRA Ground Water Project programmatic documents. The Shiprock site consists of two, interconnected hydrogeologic systems: the terrace system and the floodplain system. Separate compliance strategies are proposed for these two systems. The compliance strategy for the terrace aquifer is no remediation with the application of supplemental standards based on classification of the terrace aquifer as having Class III (limited-use) ground water. The compliance strategy for the floodplain aquifer is active remediation using a subsurface biological barrier. These strategies were selected by applying site-specific data to the compliance framework developed in the UMTRA Ground Water programmatic environmental impact statement (PEIS) (DOE, 1994a). The site conceptual model indicates that milling-related contamination has impacted the ground water in the terrace and floodplain aquifers. Ground water occurs in both aquifers in alluvium and in fractures in the underlying Cretaceous age Mancos Shale. A mound of ground water related to fluids from the milling operations is thought to exist in the terrace aquifer below the area where settling ponds were in use during the mill operations. Most of the water occurring in the floodplain aquifer is from recharge from the San Juan River

  5. Corrective Action Investigation Plan for Corrective Action Unit 137: Waste Disposal Sites, Nevada Test Site, Nevada

    International Nuclear Information System (INIS)

    Wickline, Alfred

    2005-01-01

    This Corrective Action Investigation Plan (CAIP) contains project-specific information including facility descriptions, environmental sample collection objectives, and criteria for conducting site investigation activities at Corrective Action Unit (CAU) 137: Waste Disposal Sites. This CAIP has been developed in accordance with the ''Federal Facility Agreement and Consent Order'' (FFACO) (1996) that was agreed to by the State of Nevada, the U.S. Department of Energy (DOE), and the U.S. Department of Defense. Corrective Action Unit 137 contains sites that are located in Areas 1, 3, 7, 9, and 12 of the Nevada Test Site (NTS), which is approximately 65 miles (mi) northwest of Las Vegas, Nevada (Figure 1-1). Corrective Action Unit 137 is comprised of the eight corrective action sites (CASs) shown on Figure 1-1 and listed below: (1) CAS 01-08-01, Waste Disposal Site; (2) CAS 03-23-01, Waste Disposal Site; (3) CAS 03-23-07, Radioactive Waste Disposal Site; (4) CAS 03-99-15, Waste Disposal Site; (5) CAS 07-23-02, Radioactive Waste Disposal Site; (6) CAS 09-23-07, Radioactive Waste Disposal Site; (7) CAS 12-08-01, Waste Disposal Site; and (8) CAS 12-23-07, Waste Disposal Site. The Corrective Action Investigation (CAI) will include field inspections, radiological surveys, geophysical surveys, sampling of environmental media, analysis of samples, and assessment of investigation results, where appropriate. Data will be obtained to support corrective action alternative evaluations and waste management decisions. The CASs in CAU 137 are being investigated because hazardous and/or radioactive constituents may be present in concentrations that could potentially pose a threat to human health and the environment. Existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives for the CASs. Additional information will be generated by conducting a CAI before evaluating and selecting corrective action

  6. Oskarshamn site investigation. Programme for further investigations of bedrock, soil, water and environment in Laxemar subarea

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-03-15

    SKB (the Swedish Nuclear Fuel and Waste Management Co), has been conducting a site investigation at Simpevarp and Laxemar in Oskarshamn for siting of a final repository for spent nuclear fuel. An equivalent investigation is being conducted in Forsmark in Ohmmeter's. The initial part of the site investigations had been completed for the both of the subareas Simpevarp and Laxemar in the autumn of 2004. Based on the results of these investigations, SKB preliminarily prioritized the Laxemar subarea for further investigations. A programme was presented for the first stage of the complete site investigation in the Laxemar subarea, along with the main features of the remainder of the site investigation. The programme included investigations up until the summer of 2005 and was particularly aimed at obtaining answers to several vital questions so that the subsequent investigations could be focused on the rock areas judged to be most suitable for a final repository. These investigations have now been completed. This report presents the programme for the remainder of the site investigation. The points of departure are the general goals for the Deep Repository Project during the site investigation phase, analyses and evaluations of data from completed investigations, and the needs for additional data to be able to evaluate the site as a siting alternative for the final repository. The account mainly covers the investigations on the site. All other work - analyses, site descriptive modelling, facility design, safety assessments and studies and assessments of consequences for the environment, human health and society - are only mentioned to the extent necessary in order to place the investigations in their context. The direction of the site investigation in Oskarshamn and the investigation programme presented in this report is based on SKB's preliminary decision to prioritize the Laxemar subarea for further investigations. A final decision on the direction of the site

  7. Vadose zone investigations at the Lawrence Livermore National Laboratory Superfund Site: An overview

    International Nuclear Information System (INIS)

    Iovenitti, J.L.; Nitao, J.J.; Bishop, D.J.

    1992-09-01

    Lawrence Livermore National Laboratory (LLNL)is investigating the fate and transport of vadose zone contaminants at their Livermore site in Livermore, California. The principal objectives of this work are to identify potential source areas at the Livermore site which require remediation, to prioritize those areas, and finally, to optimize the remediation process. Primary contaminants of interest for this investigation are volatile organic compounds (VOCs) and tritium. A fully integrated, three-part program, consisting of quantitative modeling, field studies, and laboratory measurements, is in progress. To evaluate and predict vadose zone contaminant migration, quantitative modeling is used. Our modeling capabilities are being enhanced through the development of a multicomponent,three-dimensional,nonaqueous phase liquid-liquid-vapor,nonisothermal flow and transport computer code. This code will be also used to evaluate vadose zone remediation requirements. Field studies to acquire LLNL site-specific soil (sediment) characteristics for computer code calibration and validation include subsurf ace lithologic and contaminant profiling, in situ soil moisture content, ground surface emission flux of VOCs and tritium, transpiration of tritium, and ground surface evapotranspiration of water. Multilevel vadose zone monitoring devices are used to monitor the gaseous and aqueous transport of contaminants

  8. Site observational work plan for the UMTRA Project site at Monument Valley, Arizona

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-01

    The site observational work plan (SOWP) for the Monument Valley, Arizona, US Department of Energy (DOE) Uranium Mill Tailings Remedial Action (UMTRA) Project site is one of the first site-specific documents developed to achieve ground water compliance at the site. This SOWP applies information about the Monument Valley site to a regulatory compliance framework that identifies strategies that could be used to meet ground water compliance. The compliance framework was developed in the UMTRA Ground Water programmatic environmental impact statement (DOE, 1995). The DOE`s goal is to implement a cost-effective site strategy that complies with the US Environmental Protection Agency (EPA) ground water standards and protects human health and the environment. The compliance strategy that emerges in the final version of the SOWP will assess potential environmental impacts and provide stakeholder a forum for review and comment. When the compliance strategy is acceptable, it will be detailed in a remedial action plan that will be subject to review by the state and/or tribe and concurrence by the US Nuclear Regulatory Commission (NRC). Information available for the preparation of this SOWP indicates active remediation is the most likely compliance strategy for the Monument Valley site. Additional data are needed to determine the most effective remediation technology.

  9. Site observational work plan for the UMTRA Project site at Monument Valley, Arizona

    International Nuclear Information System (INIS)

    1995-09-01

    The site observational work plan (SOWP) for the Monument Valley, Arizona, US Department of Energy (DOE) Uranium Mill Tailings Remedial Action (UMTRA) Project site is one of the first site-specific documents developed to achieve ground water compliance at the site. This SOWP applies information about the Monument Valley site to a regulatory compliance framework that identifies strategies that could be used to meet ground water compliance. The compliance framework was developed in the UMTRA Ground Water programmatic environmental impact statement (DOE, 1995). The DOE's goal is to implement a cost-effective site strategy that complies with the US Environmental Protection Agency (EPA) ground water standards and protects human health and the environment. The compliance strategy that emerges in the final version of the SOWP will assess potential environmental impacts and provide stakeholder a forum for review and comment. When the compliance strategy is acceptable, it will be detailed in a remedial action plan that will be subject to review by the state and/or tribe and concurrence by the US Nuclear Regulatory Commission (NRC). Information available for the preparation of this SOWP indicates active remediation is the most likely compliance strategy for the Monument Valley site. Additional data are needed to determine the most effective remediation technology

  10. Review of data types for the SKB site investigation programme

    Energy Technology Data Exchange (ETDEWEB)

    Klos, Richard

    2002-11-01

    SKB is currently undertaking a detailed site investigation programme (SIP) to characterise the geology and surface ecosystems in areas around potential sites for a planned repository for spent nuclear fuel. This report reviews site specific and generic data types needed to characterise biosphere processes relevant to the evaluation of long-term radiological safety in the context of assessments of future impacts arising from the deep geologic disposal of spent nuclear fuel. Focus is on the types of data that make up the different elements of radiological assessment models and how the data used relate to site-specific characteristics. The relevance of the SIP to the development of assessment models for long-term assessment is addressed, including the representation of the geosphere-biosphere interface. Reference to SKB's programme is made in order to determine how well the current programme will meet the needs of assessment models that will be developed and used in the assessment of long-term safety. The review also provides SSI with a basis for the planning of further SSI R and D work. The process, by which site-specific information is converted into a form suitable for use in numerical assessment models, can be quite complex. An overview of assessment model concepts is provided and the links between these and real-word site information considered. Focusing on the needs of assessment models, the review provides a summary of the main types of analyses and site-specific models that are needed for safety evaluations. Review of the SIP indicates that information from the programme feeds into a set of detailed site description models. However there is a gap between the descriptive components and the detailed model descriptions needed to configure numerical assessment models. Details of system evolution are not clearly dealt with in the programme. The SIP focuses on a detailed description of the site the present day. However, radiological impacts are not expected to

  11. Review of data types for the SKB site investigation programme

    International Nuclear Information System (INIS)

    Klos, Richard

    2002-11-01

    SKB is currently undertaking a detailed site investigation programme (SIP) to characterise the geology and surface ecosystems in areas around potential sites for a planned repository for spent nuclear fuel. This report reviews site specific and generic data types needed to characterise biosphere processes relevant to the evaluation of long-term radiological safety in the context of assessments of future impacts arising from the deep geologic disposal of spent nuclear fuel. Focus is on the types of data that make up the different elements of radiological assessment models and how the data used relate to site-specific characteristics. The relevance of the SIP to the development of assessment models for long-term assessment is addressed, including the representation of the geosphere-biosphere interface. Reference to SKB's programme is made in order to determine how well the current programme will meet the needs of assessment models that will be developed and used in the assessment of long-term safety. The review also provides SSI with a basis for the planning of further SSI R and D work. The process, by which site-specific information is converted into a form suitable for use in numerical assessment models, can be quite complex. An overview of assessment model concepts is provided and the links between these and real-word site information considered. Focusing on the needs of assessment models, the review provides a summary of the main types of analyses and site-specific models that are needed for safety evaluations. Review of the SIP indicates that information from the programme feeds into a set of detailed site description models. However there is a gap between the descriptive components and the detailed model descriptions needed to configure numerical assessment models. Details of system evolution are not clearly dealt with in the programme. The SIP focuses on a detailed description of the site the present day. However, radiological impacts are not expected to reach

  12. Intruder scenarios for site-specific waste classification

    International Nuclear Information System (INIS)

    Kennedy, W.E. Jr.

    1988-01-01

    The US Department of Energy (DOE) is currently revising its low-level radioactive waste (LLW) management requirements and guidelines for waste generated at its facilities that support defense missions. Specifically, draft DOE 5820.2A, Chapter 3, describes the purpose, policy, and requirements necessary for the management of defense LLW. The draft DOE policy calls for DOE LLW operations to be managed to protect the health and safety of the public, preserve the environment, and ensure that no remedial action will be necessary after termination of operations. The requirements and guidelines apply to radioactive wastes but are also intended to apply to mixed hazardous and radioactive wastes as defined in draft DOE 5400.5, Hazardous and Radioactive Mixed Waste. The basic approach used by DOE is to establish overall performance objectives in terms of ground-water protection and public radiation dose limits and to require site-specific performance assessments to determine compliance. As a result of these performance assessments, each site shall develop waste acceptance criteria that define the allowable quantities and concentrations of specific radioisotopes. Additional limitations on waste disposal design, waste form, and waste treatment shall also be developed on a site-specific basis. As a key step in the site-specific performance assessments, an evaluation must be conducted of potential radiation doses to intruders who may inadvertently move onto a closed DOE LLW disposal site after loss of institutional controls must be conducted. This paper describes the types of intruder scenarios that should be considered when performing this step of the site-specific performance assessment

  13. DOE site-specific threat assessment

    International Nuclear Information System (INIS)

    West, D.J.; Al-Ayat, R.A.; Judd, B.R.

    1985-01-01

    A facility manager faced with the challenges of protecting a nuclear facility against potential threats must consider the likelihood and consequences of such threats, know the capabilities of the facility safeguards and security systems, and make informed decisions about the cost-effectivness of safeguards and security upgrades. To help meet these challenges, the San Francisco Operations Office of the Department of Energy, in conjunction with the Lawrence Livermore Laboratory, has developed a site-specific threat assessment approach and a quantitative model to improve the quality and consistency of site-specific threat assessment and resultant security upgrade decisions at sensitive Department of Energy facilities. 5 figs

  14. Site specific atomic polarizabilities in endohedral fullerenes and carbon onions

    International Nuclear Information System (INIS)

    Zope, Rajendra R.; Baruah, Tunna; Bhusal, Shusil; Basurto, Luis; Jackson, Koblar

    2015-01-01

    We investigate the polarizability of trimetallic nitride endohedral fullerenes by partitioning the total polarizability into site specific components. This analysis indicates that the polarizability of the endohedral fullerene is essentially due to the outer fullerene cage and has insignificant contribution from the encapsulated unit. Thus, the outer fullerene cages effectively shield the encapsulated clusters and behave like Faraday cages. The polarizability of endohedral fullerenes is slightly smaller than the polarizability of the corresponding bare carbon fullerenes. The application of the site specific polarizabilities to C 60 @C 240 and C 60 @C 180 onions shows that, compared to the polarizability of isolated C 60 fullerene, the encapsulation of the C 60 in C 240 and C 180 fullerenes reduces its polarizability by 75% and 83%, respectively. The differences in the polarizability of C 60 in the two onions is a result of differences in the bonding (intershell electron transfer), fullerene shell relaxations, and intershell separations. The site specific analysis further shows that the outer atoms in a fullerene shell contribute most to the fullerene polarizability

  15. Site specific atomic polarizabilities in endohedral fullerenes and carbon onions

    Science.gov (United States)

    Zope, Rajendra R.; Bhusal, Shusil; Basurto, Luis; Baruah, Tunna; Jackson, Koblar

    2015-08-01

    We investigate the polarizability of trimetallic nitride endohedral fullerenes by partitioning the total polarizability into site specific components. This analysis indicates that the polarizability of the endohedral fullerene is essentially due to the outer fullerene cage and has insignificant contribution from the encapsulated unit. Thus, the outer fullerene cages effectively shield the encapsulated clusters and behave like Faraday cages. The polarizability of endohedral fullerenes is slightly smaller than the polarizability of the corresponding bare carbon fullerenes. The application of the site specific polarizabilities to C60@C240 and C60@C180 onions shows that, compared to the polarizability of isolated C60 fullerene, the encapsulation of the C60 in C240 and C180 fullerenes reduces its polarizability by 75% and 83%, respectively. The differences in the polarizability of C60 in the two onions is a result of differences in the bonding (intershell electron transfer), fullerene shell relaxations, and intershell separations. The site specific analysis further shows that the outer atoms in a fullerene shell contribute most to the fullerene polarizability.

  16. Site Characterization Work Plan for Gnome-Coach Site, New Mexico

    Energy Technology Data Exchange (ETDEWEB)

    DOE/NV

    2001-02-13

    Project Gnome was the first nuclear experiment conducted under the U.S. Atomic Energy Commission (AEC), predecessor to the U.S. Department of Energy (DOE), Plowshare Program. Gnome was part of a joint government-industry experiment focused on developing nuclear devices exclusively for peaceful purposes. The intent of the Gnome experiment was to evaluate the effects of a nuclear detonation in a salt medium. Historically, Project Gnome consisted of a single detonation of a nuclear device on December 10, 1961. Since the Gnome detonation, the AEC/DOE has conducted surface restoration, site reconnaissance, and decontamination and decommissioning activities at the site. In addition, annual groundwater sampling is performed under a long-term hydrological monitoring program begun in 1980. Coach, an experiment to be located near the Gnome project, was initially scheduled for 1963. Although construction and rehabilitation were completed for Coach, the experiment was canceled and never executed. Known collectively as Project Gnome-Coach, the site is situated within the Salado Formation approximately 25 miles east of Carlsbad, New Mexico, in Eddy County, and is comprised of nearly 680 acres, of which 60 acres are disturbed from the combined AEC/DOE operations. The scope of this work plan is to document the environmental objectives and the proposed technical site investigation strategies that will be utilized for the site characterization of the project. The subsurface at the Gnome-Coach site has two contaminant sources that are fundamentally different in terms of both their stratigraphic location and release mechanism. The goal of this characterization is to collect data of sufficient quantity and quality to establish current site conditions and to use the data to identify and evaluate if further action is required to protect human health and the environment and achieve permanent closure of the site. The results of these activities will be presented in a subsequent corrective

  17. Site specific modification of the human plasma proteome by methylglyoxal

    International Nuclear Information System (INIS)

    Kimzey, Michael J.; Kinsky, Owen R.; Yassine, Hussein N.; Tsaprailis, George; Stump, Craig S.; Monks, Terrence J.; Lau, Serrine S.

    2015-01-01

    Increasing evidence identifies dicarbonyl stress from reactive glucose metabolites, such as methylglyoxal (MG), as a major pathogenic link between hyperglycemia and complications of diabetes. MG covalently modifies arginine residues, yet the site specificity of this modification has not been thoroughly investigated. Sites of MG adduction in the plasma proteome were identified using LC–MS/MS analysis in vitro following incubation of plasma proteins with MG. Treatment of plasma proteins with MG yielded 14 putative MG hotspots from five plasma proteins (albumin [nine hotspots], serotransferrin, haptoglobin [2 hotspots], hemopexin, and Ig lambda-2 chain C regions). The search results revealed two versions of MG-arginine modification, dihydroxyimidazolidine (R + 72) and hydroimidazolone (R + 54) adducts. One of the sites identified was R257 in human serum albumin, which is a critical residue located in drug binding site I. This site was validated as a target for MG modification by a fluorescent probe displacement assay, which revealed significant drug dissociation at 300 μM MG from a prodan–HSA complex (75 μM). Moreover, twelve human plasma samples (six male, six female, with two type 2 diabetic subjects from both genders) were analyzed using multiple reaction monitoring (MRM) tandem mass spectrometry and revealed the presence of the MG-modified albumin R257 peptide. These data provide insights into the nature of the site-specificity of MG modification of arginine, which may be useful for therapeutic treatments that aim to prevent MG-mediated adverse responses in patients. - Highlights: • Methylglyoxal (MG) selectively modifies arginine sites in human plasma proteome. • Dihydroxyimidazolidine and hydroimidazolone adducts on serum albumin identified • MG modification on albumin R257 associated with loss of drug site I binding capacity • MRM-tandem mass spectrometry enables sensitive detection of albumin MG-R257. • Site-specific MG modification may

  18. Site specific modification of the human plasma proteome by methylglyoxal

    Energy Technology Data Exchange (ETDEWEB)

    Kimzey, Michael J.; Kinsky, Owen R. [Southwest Environmental Health Sciences Center, Department of Pharmacology & Toxicology, College of Pharmacy, The University of Arizona, Tucson, AZ 85721 (United States); Yassine, Hussein N. [Department of Medicine, The University of Arizona, Tucson, AZ 85721 (United States); Tsaprailis, George [Southwest Environmental Health Sciences Center, Department of Pharmacology & Toxicology, College of Pharmacy, The University of Arizona, Tucson, AZ 85721 (United States); Stump, Craig S. [Department of Medicine, The University of Arizona, Tucson, AZ 85721 (United States); Southern Arizona VA Health Care System, Tucson, AZ 85723 (United States); Monks, Terrence J. [Southwest Environmental Health Sciences Center, Department of Pharmacology & Toxicology, College of Pharmacy, The University of Arizona, Tucson, AZ 85721 (United States); Lau, Serrine S., E-mail: lau@pharmacy.arizona.edu [Southwest Environmental Health Sciences Center, Department of Pharmacology & Toxicology, College of Pharmacy, The University of Arizona, Tucson, AZ 85721 (United States)

    2015-12-01

    Increasing evidence identifies dicarbonyl stress from reactive glucose metabolites, such as methylglyoxal (MG), as a major pathogenic link between hyperglycemia and complications of diabetes. MG covalently modifies arginine residues, yet the site specificity of this modification has not been thoroughly investigated. Sites of MG adduction in the plasma proteome were identified using LC–MS/MS analysis in vitro following incubation of plasma proteins with MG. Treatment of plasma proteins with MG yielded 14 putative MG hotspots from five plasma proteins (albumin [nine hotspots], serotransferrin, haptoglobin [2 hotspots], hemopexin, and Ig lambda-2 chain C regions). The search results revealed two versions of MG-arginine modification, dihydroxyimidazolidine (R + 72) and hydroimidazolone (R + 54) adducts. One of the sites identified was R257 in human serum albumin, which is a critical residue located in drug binding site I. This site was validated as a target for MG modification by a fluorescent probe displacement assay, which revealed significant drug dissociation at 300 μM MG from a prodan–HSA complex (75 μM). Moreover, twelve human plasma samples (six male, six female, with two type 2 diabetic subjects from both genders) were analyzed using multiple reaction monitoring (MRM) tandem mass spectrometry and revealed the presence of the MG-modified albumin R257 peptide. These data provide insights into the nature of the site-specificity of MG modification of arginine, which may be useful for therapeutic treatments that aim to prevent MG-mediated adverse responses in patients. - Highlights: • Methylglyoxal (MG) selectively modifies arginine sites in human plasma proteome. • Dihydroxyimidazolidine and hydroimidazolone adducts on serum albumin identified • MG modification on albumin R257 associated with loss of drug site I binding capacity • MRM-tandem mass spectrometry enables sensitive detection of albumin MG-R257. • Site-specific MG modification may

  19. Multi-site pain and working conditions as predictors of work ability in a 4-year follow-up among food industry employees.

    Science.gov (United States)

    Neupane, S; Virtanen, P; Leino-Arjas, P; Miranda, H; Siukola, A; Nygård, C-H

    2013-03-01

    We investigated the separate and joint effects of multi-site musculoskeletal pain and physical and psychosocial exposures at work on future work ability. A survey was conducted among employees of a Finnish food industry company in 2005 (n = 1201) and a follow-up survey in 2009 (n = 734). Information on self-assessed work ability (current work ability on a scale from 0 to 10; 7 = poor work ability), multi-site musculoskeletal pain (pain in at least two anatomical areas of four), leisure-time physical activity, body mass index and physical and psychosocial exposures was obtained by questionnaire. The separate and joint effects of multi-site pain and work exposures on work ability at follow-up, among subjects with good work ability at baseline, were assessed by logistic regression, and p-values for the interaction derived. Compared with subjects with neither multi-site pain nor adverse work exposure, multi-site pain at baseline increased the risk of poor work ability at follow-up, allowing for age, gender, occupational class, body mass index and leisure-time physical activity. The separate effects of the work exposures on work ability were somewhat smaller than those of multi-site pain. Multi-site pain had an interactive effect with work environment and awkward postures, such that no association of multi-site pain with poor work ability was seen when work environment was poor or awkward postures present. The decline in work ability connected with multi-site pain was not increased by exposure to adverse physical or psychosocial factors at work. © 2012 European Federation of International Association for the Study of Pain Chapters.

  20. Remedial Investigation/Feasibility Study Work Plan for the 200-UP-1 Groundwater Operable Unit, Hanford Site, Richland, Washington

    International Nuclear Information System (INIS)

    1994-01-01

    This work plan identifies the objectives, tasks, and schedule for conducting a Remedial Investigation/Feasibility Study for the 200-UP-1 Groundwater Operable Unit in the southern portion of the 200 West Groundwater Aggregate Area of the Hanford Site. The 200-UP-1 Groundwater Operable Unit addresses contamination identified in the aquifer soils and groundwater within its boundary, as determined in the 200 West Groundwater Aggregate Area Management Study Report (AAMSR) (DOE/RL 1992b). The objectives of this work plan are to develop a program to investigate groundwater contaminants in the southern portion of the 200 West Groundwater Aggregate Area that were designated for Limited Field Investigations (LFIs) and to implement Interim Remedial Measures (IRMs) recommended in the 200 West Groundwater AAMSR. The purpose of an LFI is to evaluate high priority groundwater contaminants where existing data are insufficient to determine whether an IRM is warranted and collect sufficient data to justify and implement an IRM, if needed. A Qualitative Risk Assessment (QRA) will be performed as part of the LFI. The purpose of an IRM is to develop and implement activities, such as contaminant source removal and groundwater treatment, that will ameliorate some of the more severe potential risks of groundwater contaminants prior to the RI and baseline Risk Assessment (RA) to be conducted under the Final Remedy Selection (FRS) at a later date. This work plan addresses needs of a Treatability Study to support the design and implementation of an interim remedial action for the Uranium- 99 T c -Nitrate multi-contaminant IRM plume identified beneath U Plant

  1. Recent Developments in the Site-Specific Immobilization of Proteins onto Solid Supports

    Energy Technology Data Exchange (ETDEWEB)

    Camarero, J A

    2007-02-21

    Immobilization of proteins onto surfaces is of great importance in numerous applications, including protein analysis, drug screening, and medical diagnostics, among others. The success of all these technologies relies on the immobilization technique employed to attach a protein to the corresponding surface. Non-specific physical adsorption or chemical cross-linking with appropriate surfaces results in the immobilization of the protein in random orientations. Site-specific covalent attachment, on the other hand, leads to molecules being arranged in a definite, orderly fashion and allows the use of spacers and linkers to help minimize steric hindrances between the protein and the surface. The present work reviews the latest chemical and biochemical developments for the site-specific covalent attachment of proteins onto solid supports.

  2. Remedial investigation/feasibility study work plan for the 100-KR-1 operable unit, Hanford Site, Richland, Washington

    International Nuclear Information System (INIS)

    1992-07-01

    Four areas of the Hanford Site (the 100, 200, 300, and 1100 Areas) have been included on the US Environmental Protection Agency's (EPA's) National Priorities List (NPL) under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). Figure 1-1 shows the location of these areas. Under the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement, Ecology et al. 1990a), signed by the Washington State Department of Ecology (Ecology), EPA, and the US Department of Energy (DOE), more than 1,000 inactive waste disposal and unplanned release sites on the Hanford Site have been grouped into a number of source and groundwater operable units. These operable units contain contamination in the form of hazardous waste, radioactive/hazardous mixed waste, and other CERCLA hazardous substances. Also included in the Tri-Party Agreement are 55 Resource Conservation and Recovery Act (RCRA) treatment, storage, or disposal (TSD) facilities that will be closed or permitted to operate in accordance with RCRA regulations, under the authority of Chapter 173-303 Washington Administrative Code (WAC). Some of the TSD facilities are included in the operable units. This work plan and the attached supporting project plans establish the objectives, procedures, tasks, and schedule for conducting the CERCLA remedial investigation/feasibility study (RI/FS) for the 100-KR-1 operable unit. The 100-KR-1 source operable unit is one of three source operable units in the 100-K Area. Source operable units include facilities and unplanned release sites that are potential sources of hazardous substance contamination

  3. Site-specific evaluation of safety issues for high-level waste disposal in crystalline rocks. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Jobmann, M. (ed.) [DBE Technology GmbH, Peine (Germany)

    2016-03-31

    In the past, German research and development (R and D) activities regarding the disposal of radioactive waste, including spent nuclear fuel, focused mainly on domal rock salt because rock salt was the preferred host rock formation. In addition, generic R and D work regarding alternative host rocks (crystalline rocks and claystones) had been performed as well for a long time but with lower intensity. Around the year 2000, as a consequence of the moratorium on the Gorleben site, the Federal Government decided to have argillaceous rocks and crystalline rocks investigated in more detail. As Germany does not have any underground research and host rock characterization facilities, international cooperation received a high priority in the German R and D programme for high-level waste (HLW) disposal in order to increase the knowledge regarding alternative host rocks. Major cornerstones of the cooperation are joint projects and experiments conducted especially in underground research laboratories (URL) in crystalline rocks at the Grimsel Test Site (Switzerland) and the Hard Rock Laboratory (HRL) Aespoe(Sweden) and in argillaceous rocks at the URL Mont Terri (Switzerland) and Bure (France). In 2001, the topic of radioactive waste disposal was integrated into the agreement between the former Russian Ministry of Atomic Energy (Minatom, now Rosatom) and the German Ministry of Labor (BMWA), now Ministry of Economic Affairs and Energy (BMWi), on cooperation regarding R and D on the peaceful utilization of nuclear power (agreement on ''Wirtschaftlich-Technische Zusammenarbeit'' WTZ). The intention was to have a new and interesting opportunity for international R and D cooperation regarding HLW disposal in crystalline rocks and the unique possibility to perform site-specific work, to test the safety demonstration tools available, and to expand the knowledge to all aspects specific to these host rocks. Another motivation for joining this cooperation was the

  4. Savannah River Site's Site Specific Plan

    International Nuclear Information System (INIS)

    1991-01-01

    This Site Specific Plan (SSP) has been prepared by the Savannah River Site (SRS) in order to show the Environmental Restoration and Waste Management activities that were identified during the preparation of the Department of Energy-Headquarters (DOE-HQ) Environmental Restoration and Waste Management Five-Year Plan (FYP) for FY 1992--1996. The SSP has been prepared in accordance with guidance received from DOE-HQ. DOE-SR is accountable to DOE-HQ for the implementation of this plan. The purpose of the SSP is to develop a baseline for policy, budget, and schedules for the DOE Environmental Restoration and Waste Management activities. The plan explains accomplishments since the Fiscal Year (FY) 1990 plan, demonstrates how present and future activities are prioritized, identifies currently funded activities and activities that are planned to be funded in the upcoming fiscal year, and describes future activities that SRS is considering

  5. A summary of INSITE activities in tracking SKB's spent fuel repository site investigations from 2002-2009 and of advice provided to the regulatory authorities on the status of site understanding at the end of the surface-based investigations

    International Nuclear Information System (INIS)

    Chapman, Neil; Bath, Adrian; Geier, Joel; Ove Stephansson; Tiren, Sven; Tsang, Chin-Fu

    2010-11-01

    SSM and its predecessor SKI employed a team of earth scientists who followed and reviewed SKB's investigations of the potential spent nuclear fuel repository sites at Forsmark and Laxemar. This group was named INSITE (INdependent Site Investigation Tracking and Evaluation) and began its work in 2002 and completed its task with the review of the final versions SKB's site descriptive models, SDM-Site, in 2009. This report is a summary of INSITE's work over the eight-and-a-half year period of the site investigations and the lead-in and the wind-down to the work. It is intended to provide an outline and a record of how INSITE has worked and how its advice was generated and provided to SKI and, latterly, to SSM. Together with all the other documentation generated by INSITE, this report is intended to support the regulatory review of SKB's licence application for a spent nuclear fuel repository

  6. Site specific atomic polarizabilities in endohedral fullerenes and carbon onions

    Energy Technology Data Exchange (ETDEWEB)

    Zope, Rajendra R., E-mail: rzope@utep.edu; Baruah, Tunna [Department of Physics, The University of Texas at El Paso, El Paso, Texas 79958 (United States); Computational Science Program, The University of Texas at El Paso, El Paso, Texas 79958 (United States); Bhusal, Shusil; Basurto, Luis [Department of Physics, The University of Texas at El Paso, El Paso, Texas 79958 (United States); Jackson, Koblar [Physics Department and Science of Advanced Materials Ph.D. Program, Central Michigan University, Mt. Pleasant, Michigan 48859 (United States)

    2015-08-28

    We investigate the polarizability of trimetallic nitride endohedral fullerenes by partitioning the total polarizability into site specific components. This analysis indicates that the polarizability of the endohedral fullerene is essentially due to the outer fullerene cage and has insignificant contribution from the encapsulated unit. Thus, the outer fullerene cages effectively shield the encapsulated clusters and behave like Faraday cages. The polarizability of endohedral fullerenes is slightly smaller than the polarizability of the corresponding bare carbon fullerenes. The application of the site specific polarizabilities to C{sub 60}@C{sub 240} and C{sub 60}@C{sub 180} onions shows that, compared to the polarizability of isolated C{sub 60} fullerene, the encapsulation of the C{sub 60} in C{sub 240} and C{sub 180} fullerenes reduces its polarizability by 75% and 83%, respectively. The differences in the polarizability of C{sub 60} in the two onions is a result of differences in the bonding (intershell electron transfer), fullerene shell relaxations, and intershell separations. The site specific analysis further shows that the outer atoms in a fullerene shell contribute most to the fullerene polarizability.

  7. GSHSite: exploiting an iteratively statistical method to identify s-glutathionylation sites with substrate specificity.

    Directory of Open Access Journals (Sweden)

    Yi-Ju Chen

    Full Text Available S-glutathionylation, the covalent attachment of a glutathione (GSH to the sulfur atom of cysteine, is a selective and reversible protein post-translational modification (PTM that regulates protein activity, localization, and stability. Despite its implication in the regulation of protein functions and cell signaling, the substrate specificity of cysteine S-glutathionylation remains unknown. Based on a total of 1783 experimentally identified S-glutathionylation sites from mouse macrophages, this work presents an informatics investigation on S-glutathionylation sites including structural factors such as the flanking amino acids composition and the accessible surface area (ASA. TwoSampleLogo presents that positively charged amino acids flanking the S-glutathionylated cysteine may influence the formation of S-glutathionylation in closed three-dimensional environment. A statistical method is further applied to iteratively detect the conserved substrate motifs with statistical significance. Support vector machine (SVM is then applied to generate predictive model considering the substrate motifs. According to five-fold cross-validation, the SVMs trained with substrate motifs could achieve an enhanced sensitivity, specificity, and accuracy, and provides a promising performance in an independent test set. The effectiveness of the proposed method is demonstrated by the correct identification of previously reported S-glutathionylation sites of mouse thioredoxin (TXN and human protein tyrosine phosphatase 1b (PTP1B. Finally, the constructed models are adopted to implement an effective web-based tool, named GSHSite (http://csb.cse.yzu.edu.tw/GSHSite/, for identifying uncharacterized GSH substrate sites on the protein sequences.

  8. Occupational exposure to crystalline silica at Alberta work sites.

    Science.gov (United States)

    Radnoff, Diane; Todor, Maria S; Beach, Jeremy

    2014-01-01

    Although crystalline silica has been recognized as a health hazard for many years, it is still encountered in many work environments. Numerous studies have revealed an association between exposure to respirable crystalline silica and the development of silicosis and other lung diseases including lung cancer. Alberta Jobs, Skills, Training and Labour conducted a project to evaluate exposure to crystalline silica at a total of 40 work sites across 13 industries. Total airborne respirable dust and respirable crystalline silica concentrations were quite variable, but there was a potential to exceed the Alberta Occupational Exposure Limit (OEL) of 0.025 mg/m(3) for respirable crystalline silica at many of the work sites evaluated. The industries with the highest potentials for overexposure occurred in sand and mineral processing (GM 0.090 mg/m(3)), followed by new commercial building construction (GM 0.055 mg/m(3)), aggregate mining and crushing (GM 0.048 mg/m(3)), abrasive blasting (GM 0.027 mg/m(3)), and demolition (GM 0.027 mg/m(3)). For worker occupations, geometric mean exposure ranged from 0.105 mg/m(3) (brick layer/mason/concrete cutting) to 0.008 mg/m(3) (dispatcher/shipping, administration). Potential for GM exposure exceeding the OEL was identified in a number of occupations where it was not expected, such as electricians, carpenters and painters. These exposures were generally related to the specific task the worker was doing, or arose from incidental exposure from other activities at the work site. The results indicate that where there is a potential for activities producing airborne respirable crystalline silica, it is critical that the employer include all worker occupations at the work site in their hazard assessment. There appears to be a relationship between airborne total respirable dust concentration and total respirable dust concentrations, but further study is require to fully characterize this relationship. If this relationship holds true

  9. Geochemical investigation of UMTRAP designated site at Durango, Colorado

    International Nuclear Information System (INIS)

    Markos, G.; Bush, K.J.

    1983-09-01

    This report is the result of a geochemical investigation of the former uranium mill and tailings site at Durango, Colorado. This is one in a series of site specific geochemical investigations performed on the inactive uranium mill tailings included in the UMTRA Project. The objectives of the investigation are to characterize the geochemistry, to determine the contaminant distribution resulting from the former milling activities and tailings, and to infer chemical pathways and transport mechanisms from the contaminant distribution. The results will be used to model contaminant migration and to develop criteria for long-term containment media such as a cover system which is impermeable to contaminant migration. This report assumes a familiarity with the hydrologic conditions of the site and the geochemical concepts underlying the investigation. The results reported are based on a one-time sampling of waters and solid material from the background, the area adjacent to the site, and the site. The solid samples are water extracted remove easily soluble salts and acids extracted to remove cabonates and hydroxides. The water extracts and solid samples were analyzed for the major and trace elements. A limited number of samples were analyzed for radiological components. The report includes the methods of sampling, sample processing, analysis, and data interpretation. Three major conclusions are: (1) carbonate salts and low TDS characterize the tailings; (2) the adjacent area and raffinate ponds contain contaminants deposited by a single event of fluid permeation of the soils; and (3) the Animas River adjacent to the site has elevated gross alpha activity attributed to 226 Ra in the sediments derived from the tailings or milling activities

  10. Using a site-specific technical error to establish training responsiveness: a preliminary explorative study.

    Science.gov (United States)

    Weatherwax, Ryan M; Harris, Nigel K; Kilding, Andrew E; Dalleck, Lance C

    2018-01-01

    Even though cardiorespiratory fitness (CRF) training elicits numerous health benefits, not all individuals have positive training responses following a structured CRF intervention. It has been suggested that the technical error (TE), a combination of biological variability and measurement error, should be used to establish specific training responsiveness criteria to gain further insight on the effectiveness of the training program. To date, most training interventions use an absolute change or a TE from previous findings, which do not take into consideration the training site and equipment used to establish training outcomes or the specific cohort being evaluated. The purpose of this investigation was to retrospectively analyze training responsiveness of two CRF training interventions using two common criteria and a site-specific TE. Sixteen men and women completed two maximal graded exercise tests and verification bouts to identify maximal oxygen consumption (VO 2 max) and establish a site-specific TE. The TE was then used to retrospectively analyze training responsiveness in comparison to commonly used criteria: percent change of >0% and >+5.6% in VO 2 max. The TE was found to be 7.7% for relative VO 2 max. χ 2 testing showed significant differences in all training criteria for each intervention and pooled data from both interventions, except between %Δ >0 and %Δ >+7.7% in one of the investigations. Training nonresponsiveness ranged from 11.5% to 34.6%. Findings from the present study support the utility of site-specific TE criterion to quantify training responsiveness. A similar methodology of establishing a site-specific and even cohort specific TE should be considered to establish when true cardiorespiratory training adaptations occur.

  11. Site specific plan

    International Nuclear Information System (INIS)

    Hutchison, J.; Jernigan, G.

    1989-12-01

    The Environmental Restoration and Waste Management Five-Year Plan (FYP) covers the period for FY 1989 through FY 1995. The plan establishes a Department of Energy -- Headquarters (DOE-HQ) agenda for cleanup and compliance against which overall progress can be measured. The FYP covers three areas: Corrective Activities, Environmental Restoration, and Waste Management Operations. Corrective Activities are those activities necessary to bring active or standby facilities into compliance with local, state, and federal environmental regulations. Environmental restoration activities include the assessment and cleanup of surplus facilities and inactive waste sites. Waste management operations includes the treatment, storage, and disposal of wastes which are generated as a result of ongoing operations. This Site Specific Plan (SSP) has been prepared by the Savannah River Site (SRS) in order to show how environmental restoration and waste management activities that were identified during the preparation of the FYP will be implemented, tracked, and reported. The SSP describes DOE Savannah River (DOE-SR) and operating contractor, Westinghouse Savannah River Company (WSRC), organizations that are responsible, for undertaking the activities identified in this plan. The SSP has been prepared in accordance with guidance received from DOE-HQ. DOE-SR is accountable to DOE-HQ for the implementation of this plan. 8 refs., 46 figs., 23 tabs

  12. RCRA facility investigation/corrective measures study work plan for the 100-HR-3 operable unit, Hanford Site, Richland, Washington

    International Nuclear Information System (INIS)

    1992-09-01

    Four areas of the Hanford Site (the 100, 200, 300, and 1100 Areas) have been included on the US Environmental Protection Agency's (EPA's) National Priorities List (NPL) under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). Under the Hanford Federal Facility Agreement and Consent Order, signed by the Washington State Department of Ecology (Ecology), EPA, and the US Department of Energy (DOE), more than 1000 inactive waste disposal and unplanned release sites on the Hanford Site have been grouped into a number of source and groundwater operable units. These operable units contain contamination in the form of hazardous waste, radioactive/hazardous mixed waste, and other CERCLA hazardous substances. Also included in the Tri-Party Agreement are 55 Resource Conservation and Recovery Act (RCRA) treatment, storage, or disposal (TSD) facilities that will be closed or permitted to operate in accordance with RCRA regulations, under the authority of Chapter 173-303 Washington Administrative Code (WAC). Some of the TSD facilities are included in the operable units. This work plan and the attached supporting project plans establish the operable unit setting and the objectives, procedures, tasks, and schedule for conducting the RCRA facility investigation/corrective measures study (RFI/CMS) for the 100-HR-3 operable unit. The 100-HR-3 operable unit underlies the D/DR and H Areas, the 600 Area between them, and the six source operable units these areas contain. The 100-HR-3 operable unit includes all contamination found in the aquifer soils and water within its boundary. Source operable units include facilities and unplanned release sites that are potential sources of contamination. Separate work plans have been initiated for the 100-DR-1 (DOE-RL 1992a) and 100-HR-1 (DOE-RL 1992b) source operable units

  13. Remedial investigation/feasibility study work plan for the 100-BC-5 Operable Unit, Hanford Site, Richland, Washington

    International Nuclear Information System (INIS)

    1992-04-01

    Four areas of the Hanford Site (the 100, 200, 300 and 1100 Areas) have been included on the US Environmental Protection Agency's (EPA's) National Priorities List (NPL) under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). Figure 1-1 shows the location of these areas. Under the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement, Ecology et al. 1990a), signed by the Washington State Department of Ecology (Ecology), EPA, and the US Department of Energy (DOE), more than 1,000 inactive waste disposal and unplanned release sites on the Hanford Site have been grouped into a number of source and groundwater operable units. These operable units contain contamination in the form of hazardous waste, radioactive/hazardous mixed waste and other CERCLA hazardous substances. Also included in the Tri-Party Agreement are 55 Resource Conservation and Recovery Act (RCRA) treatment, storage, or disposal (TSD) facilities that will be closed or permitted to operate in accordance with RCRA regulations, under the authority of Chapter 173-303 Washington Administrative Code (WAC). Some of the TSD facilities are included in the operable units. This work plant and the attached supporting project plans establish the operable unit setting and the objectives, procedures, tasks, and schedule for conducting the CERCLA remedial investigation/feasibility study (RI/FS) for the 100-BC-5 operable unit. The 100-B/C Area consists of the 100-BC-5 groundwater operable unit and four source operable units. The 100-BC-5 operable unit includes all contamination found in the aquifer soils and water beneath the 100-B/C Area. Source operable units include facilities and unplanned release sites that are potential sources of contamination

  14. Site-specific electronic structure analysis by channeling EELS and first-principles calculations.

    Science.gov (United States)

    Tatsumi, Kazuyoshi; Muto, Shunsuke; Yamamoto, Yu; Ikeno, Hirokazu; Yoshioka, Satoru; Tanaka, Isao

    2006-01-01

    Site-specific electronic structures were investigated by electron energy loss spectroscopy (EELS) under electron channeling conditions. The Al-K and Mn-L(2,3) electron energy loss near-edge structure (ELNES) of, respectively, NiAl2O4 and Mn3O4 were measured. Deconvolution of the raw spectra with the instrumental resolution function restored the blunt and hidden fine features, which allowed us to interpret the experimental spectral features by comparing with theoretical spectra obtained by first-principles calculations. The present method successfully revealed the electronic structures specific to the differently coordinated cationic sites.

  15. Burn site groundwater interim measures work plan.

    Energy Technology Data Exchange (ETDEWEB)

    Witt, Jonathan L. (North Wind, Inc., Idaho Falls, ID); Hall, Kevin A. (North Wind, Inc., Idaho Falls, ID)

    2005-05-01

    This Work Plan identifies and outlines interim measures to address nitrate contamination in groundwater at the Burn Site, Sandia National Laboratories/New Mexico. The New Mexico Environment Department has required implementation of interim measures for nitrate-contaminated groundwater at the Burn Site. The purpose of interim measures is to prevent human or environmental exposure to nitrate-contaminated groundwater originating from the Burn Site. This Work Plan details a summary of current information about the Burn Site, interim measures activities for stabilization, and project management responsibilities to accomplish this purpose.

  16. CTCF Binding Sites in the Herpes Simplex Virus 1 Genome Display Site-Specific CTCF Occupation, Protein Recruitment, and Insulator Function.

    Science.gov (United States)

    Washington, Shannan D; Musarrat, Farhana; Ertel, Monica K; Backes, Gregory L; Neumann, Donna M

    2018-04-15

    There are seven conserved CTCF binding domains in the herpes simplex virus 1 (HSV-1) genome. These binding sites individually flank the latency-associated transcript (LAT) and the immediate early (IE) gene regions, suggesting that CTCF insulators differentially control transcriptional domains in HSV-1 latency. In this work, we show that two CTCF binding motifs in HSV-1 display enhancer blocking in a cell-type-specific manner. We found that CTCF binding to the latent HSV-1 genome was LAT dependent and that the quantity of bound CTCF was site specific. Following reactivation, CTCF eviction was dynamic, suggesting that each CTCF site was independently regulated. We explored whether CTCF sites recruit the polycomb-repressive complex 2 (PRC2) to establish repressive domains through a CTCF-Suz12 interaction and found that Suz12 colocalized to the CTCF insulators flanking the ICP0 and ICP4 regions and, conversely, was removed at early times postreactivation. Collectively, these data support the idea that CTCF sites in HSV-1 are independently regulated and may contribute to lytic-latent HSV-1 control in a site-specific manner. IMPORTANCE The role of chromatin insulators in DNA viruses is an area of interest. It has been shown in several beta- and gammaherpesviruses that insulators likely control the lytic transcriptional profile through protein recruitment and through the formation of three-dimensional (3D) chromatin loops. The ability of insulators to regulate alphaherpesviruses has been understudied to date. The alphaherpesvirus HSV-1 has seven conserved insulator binding motifs that flank regions of the genome known to contribute to the establishment of latency. Our work presented here contributes to the understanding of how insulators control transcription of HSV-1. Copyright © 2018 American Society for Microbiology.

  17. Site Specific Analyses of a Spent Nuclear Fuel Transportation Accident

    International Nuclear Information System (INIS)

    Biwer, B. M.; Chen, S. Y.

    2003-01-01

    The number of spent nuclear fuel (SNF) shipments is expected to increase significantly during the time period that the United States' inventory of SNF is sent to a final disposal site. Prior work estimated that the highest accident risks of a SNF shipping campaign to the proposed geologic repository at Yucca Mountain were in the corridor states, such as Illinois. The largest potential human health impacts would be expected to occur in areas with high population densities such as urban settings. Thus, our current study examined the human health impacts from the most plausible severe SNF transportation accidents in the Chicago metropolitan area. The RISKIND 2.0 program was used to model site-specific data for an area where the largest impacts might occur. The results have shown that the radiological human health consequences of a severe SNF rail transportation accident on average might be similar to one year of exposure to natural background radiation for those persons living a nd working in the most affected areas downwind of the actual accident location. For maximally exposed individuals, an exposure similar to about two years of exposure to natural background radiation was estimated. In addition to the accident probabilities being very low (approximately 1 chance in 10,000 or less during the entire shipping campaign), the actual human health impacts are expected to be lower if any of the accidents considered did occur, because the results are dependent on the specific location and weather conditions, such as wind speed and direction, that were selected to maximize the results. Also, comparison of the results of longer duration accident scenarios against U.S. Environmental Protection Agency guidelines was made to demonstrate the usefulness of this site-specific analysis for emergency planning purposes

  18. Stabilization of bacterially expressed erythropoietin by single site-specific introduction of short branched PEG chains at naturally occurring glycosylation sites.

    Science.gov (United States)

    Hoffmann, E; Streichert, K; Nischan, N; Seitz, C; Brunner, T; Schwagerus, S; Hackenberger, C P R; Rubini, M

    2016-05-24

    The covalent attachment of polyethylene glycol (PEG) to therapeutic proteins can improve their physicochemical properties. In this work we utilized the non-natural amino acid p-azidophenylalanine (pAzF) in combination with the chemoselective Staudinger-phosphite reaction to install branched PEG chains to recombinant unglycosylated erythropoietin (EPO) at each single naturally occurring glycosylation site. PEGylation with two short 750 or 2000 Da PEG units at positions 24, 38, or 83 significantly decreased unspecific aggregation and proteolytic degradation while biological activity in vitro was preserved or even increased in comparison to full-glycosylated EPO. This site-specific bioconjugation approach permits to analyse the impact of PEGylation at single positions. These results represent an important step towards the engineering of site-specifically modified EPO variants from bacterial expression with increased therapeutic efficacy.

  19. Site description of the SFR area at Forsmark at completion of the site investigation phase. SDM-PSU Forsmark

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-05-15

    The site descriptive model (SDM) presented in this report is an integrated model for bedrock geology, rock mechanics, bedrock hydrogeology and bedrock hydrogeochemistry of the site investigated in the SFR extension project (PSU). A description of the surface system is also included in the report. However, the surface system is not integrated with the other disciplines as new data regarding the surface system will not be available until after the completion of SDM-PSU. It is noted that SDM-PSU does not include all disciplines handled in SDM-Site Forsmark (SKB 2008b), the focus is to produce a site description that meets the needs of the SFR extension project. The overall objective of the SFR extension project is to have the application for the extension ready by 2013. This report presents an integrated site model incorporating the historic data acquired from the investigations for and construction of the existing SFR facility (1980-1986), as well as from the recent investigations for the planned extension of SFR (2008-2009). It also provides a summary of the abundant underlying data and the discipline-specific models that support the integrated site model. The description relies heavily on background reports concerning detailed data analyses and modelling in the different disciplines. It is noteworthy that the investigations conducted during the SFR extension project were guided by the choice of site prior to the investigations, which was based on the experience gained during the construction of the existing SFR facility.

  20. Site description of the SFR area at Forsmark at completion of the site investigation phase. SDM-PSU Forsmark

    International Nuclear Information System (INIS)

    2013-05-01

    The site descriptive model (SDM) presented in this report is an integrated model for bedrock geology, rock mechanics, bedrock hydrogeology and bedrock hydrogeochemistry of the site investigated in the SFR extension project (PSU). A description of the surface system is also included in the report. However, the surface system is not integrated with the other disciplines as new data regarding the surface system will not be available until after the completion of SDM-PSU. It is noted that SDM-PSU does not include all disciplines handled in SDM-Site Forsmark (SKB 2008b), the focus is to produce a site description that meets the needs of the SFR extension project. The overall objective of the SFR extension project is to have the application for the extension ready by 2013. This report presents an integrated site model incorporating the historic data acquired from the investigations for and construction of the existing SFR facility (1980-1986), as well as from the recent investigations for the planned extension of SFR (2008-2009). It also provides a summary of the abundant underlying data and the discipline-specific models that support the integrated site model. The description relies heavily on background reports concerning detailed data analyses and modelling in the different disciplines. It is noteworthy that the investigations conducted during the SFR extension project were guided by the choice of site prior to the investigations, which was based on the experience gained during the construction of the existing SFR facility

  1. Remedial Investigation of Hanford Site Releases to the Columbia River - 13603

    Energy Technology Data Exchange (ETDEWEB)

    Lerch, J.A.; Hulstrom, L.C. [Washington Closure Hanford, LLC, Richland, Washington 99354 (United States); Sands, J.P. [U.S Department of Energy, Richland Operations Office, Richland, Washington 99352 (United States)

    2013-07-01

    In south-central Washington State, the Columbia River flows through the U.S. Department of Energy Hanford Site. A primary objective of the Hanford Site cleanup mission is protection of the Columbia River, through remediation of contaminated soil and groundwater that resulted from its weapons production mission. Within the Columbia River system, surface water, sediment, and biota samples related to potential Hanford Site hazardous substance releases have been collected since the start of Hanford operations. The impacts from release of Hanford Site radioactive substances to the Columbia River in areas upstream, within, and downstream of the Hanford Site boundary have been previously investigated as mandated by the U.S. Department of Energy requirements under the Atomic Energy Act. The Remedial Investigation Work Plan for Hanford Site Releases to the Columbia River [1] was issued in 2008 to initiate assessment of the impacts under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 [2]. The work plan established a phased approach to characterize contaminants, assess current risks, and determine whether or not there is a need for any cleanup actions. Field investigation activities over a 120-mile stretch of the Columbia River began in October 2008 and were completed in 2010. Sampled media included surface water, pore water, surface and core sediment, island soil, and fish (carp, walleye, whitefish, sucker, small-mouth bass, and sturgeon). Information and sample results from the field investigation were used to characterize current conditions within the Columbia River and assess whether current conditions posed a risk to ecological or human receptors that would merit additional study or response actions under CERCLA. The human health and ecological risk assessments are documented in reports that were published in 2012 [3, 4]. Conclusions from the risk assessment reports are being summarized and integrated with remedial investigation

  2. Innovation and Diffusion of Site-specific Crop Management

    DEFF Research Database (Denmark)

    Pedersen, Søren Marcus; Pedersen, Jørgen Lindgaard

    2006-01-01

    Site-specific crop management or precision farming is a highly complex managementsystem for site-specific input application of lime, fertilizers and pesticides in arable farming. The Global Positioning System (GPS)is the backbone of the system. To conduct precision farming several technical systems...

  3. Final Work Plan: Phase I Investigation at Bladen, Nebraska

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, Lorraine M. [Argonne National Lab. (ANL), Argonne, IL (United States). Environmental Science Division. Applied Geosciences and Environmental Management Section; Yan, Eugene [Argonne National Lab. (ANL), Argonne, IL (United States). Environmental Science Division

    2014-07-01

    The village of Bladen is a town of population approximately 237 in the northwest part of Webster County, Nebraska, 30 mi southwest of Hastings and 140 mi southwest of Lincoln, Nebraska. In 2000, the fumigant-related compound carbon tetrachloride was detected in public water supply well PWS 68-1, at a trace level. Low-level contamination, below the maximum contamination level (MCL) of 5.0 μg/L, has been detected intermittently in well PWS 68-1 since 2000, including in the last sample taken in July 2013. In 2006, the village installed a new well, PWS 2006-1, that remains free of contamination. Because the carbon tetrachloride found in well PWS 68-1 might be linked to historical use of fumigants containing carbon tetrachloride at grain storage facilities, including its former facility in Bladen, the CCC/USDA is proposing an investigation to (1) delineate the source and extent of the carbon tetrachloride contamination potentially associated with its former facility, (2) characterize pathways and controlling factors for contaminant migration in the subsurface, and (3) establish a basis for estimating potential health and environmental risks. The work will be performed in accordance with the Intergovernmental Agreement established between the NDEQ and the Farm Service Agency of the USDA. The site investigation at Bladen will be implemented in phases, so that data collected and interpretations developed during each phase can be evaluated to determine if a subsequent phase of investigation is warranted and, if warranted, to provide effective guidance for the subsequent investigation activities. This Work Plan identifies the specific technical objectives and defines the scope of work proposed for the Phase I investigation by compiling and evaluating historical data. The proposed investigation activities will be performed on behalf of the CCC/USDA by the Environmental Science Division of Argonne National Laboratory. Argonne is a nonprofit, multidisciplinary research

  4. RCRA facility investigation/corrective measures study work plan for the 100-DR-1 operable unit, Hanford Site, Richland, Washington

    International Nuclear Information System (INIS)

    1992-09-01

    Four areas of the Hanford Site (the 100, 200, 300, and 1100 Areas) have been included on the US Environmental Protection Agency's (EPA's) National Priorities List (NPL) under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). Under the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement, Ecology et. al. 1990a), signed by the Washington State Department of Ecology (Ecology), EPA, and the US Department of Energy (DOE), more than 1,000 inactive waste disposal and unplanned release sites on the Hanford Site have been grouped into a number of source and groundwater operable units. These operable units contain contamination in the form of hazardous waste, radioactive/hazardous mixed waste, and other CERCLA hazardous substances. Also included in the Tri-Party Agreement are 55 Resource Conservation and Recovery Act (RCRA) treatment, storage, or disposal (TSD) facilities that will be closed or permitted to operate in accordance with RCRA regulations. Some of the TSD facilities are included in the operable units. This work plan and the attached supporting project plans establish the operable unit setting and the objectives, procedures, tasks, and schedule for conducting the RCRA facility investigation/corrective measures study (RFI/CMS) for the 100-DR-1 source operable unit Source operable units include facilities and unplanned release sites that are potential sources of contamination

  5. FInal Report: Site Investigation Results, 2009-2011, at Inman, Kansas

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, Lorraine M. [Argonne National Lab. (ANL), Argonne, IL (United States). Environmental Sciences Div.

    2015-05-01

    The Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA) operated a grain storage facility at the southern edge of the city of Inman, Kansas, from 1954 to 1965. During this time, commercial grain fumigants containing carbon tetrachloride were in common use by the grain storage industry to preserve grain in their facilities. In 1997, trace to low levels of carbon tetrachloride (below the maximum contamination level [MCL] of 5.0 μg/L) were detected in three private wells near the former grain storage facility at Inman, as part of a statewide USDA private well sampling program that was implemented by the Kansas Department of Health and Environment (KDHE) near former CCC/USDA facilities. No public water supply wells were identified in 1998 by the KDHE within 1 mi of the town. Carbon tetrachloride is the contaminant of primary concern at sites associated with grain storage operations. To determine whether the former CCC/USDA facility at Inman is a potential contaminant source and its possible relationship to the contamination in groundwater, the CCC/USDA agreed to conduct investigations at Inman. The investigations were performed by the Environmental Science Division of Argonne National Laboratory in accordance with the Intergovernmental Agreement between the KDHE and the Farm Service Agency of the USDA. Argonne, on behalf of the CCC/USDA, developed a Work Plan (Argonne 2007) and subsequently a Summary of Investigation Results and Proposed Work Plan (Appendix A) for a phased site investigation. The proposed work was approved by the KDHE (2007, 2011). The investigations were conducted from November 2009 to September 2011, as proposed in the two work plans. This report presents the findings of the 2009-2011 investigations at Inman.

  6. Final Report: Results of Environmental Site Investigation at Sylvan Grove, Kansas

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, Lorraine M [Argonne National Lab. (ANL), Argonne, IL (United States)

    2014-09-01

    Sylvan Grove is located in western Lincoln County, approximately 60 mi west of Salina, Kansas (Figure 1.1). From 1954 to 1966, the Commodity Credit Corporation (CCC), an agency of the U.S. Department of Agriculture (USDA), operated a grain storage facility at the northeastern edge of Sylvan Grove. During this time, commercial grain fumigants containing carbon tetrachloride were in common use to preserve grain in storage. In 1998, the Kansas Department of Health and Environment (KDHE) found carbon tetrachloride above the maximum contaminant level (MCL) of 5 μg/L in groundwater from one private well used for livestock and lawn and garden watering. The 1998 KDHE sampling at Sylvan Grove was conducted under the USDA private well sampling program. To determine whether the former CCC/USDA facility at Sylvan Grove is a potential contaminant source and its possible relationship to the contamination in groundwater, the CCC/USDA proposed to conduct an environmental site investigation, in accordance with the Intergovernmental Agreement between the KDHE and the Farm Service Agency (FSA) of the USDA. Argonne National Laboratory, on behalf of the CCC/USDA, developed a work plan (Argonne 2012) for the site investigation and a supplemental work plan for indoor and ambient air sampling (Appendix A). The proposed work was approved by the KDHE (2012a, 2013). The investigations were performed by the Environmental Science Division of Argonne National Laboratory, on behalf of the CCC/USDA. The main activities for the site investigation were conducted in June 2012, and indoor and ambient air sampling was performed in February 2013. This report presents the findings of the investigations at Sylvan Grove.

  7. Innovation and diffusion of site-specific crop management

    DEFF Research Database (Denmark)

    Pedersen, Søren Marcus; Pedersen, Jørgen Lindgaard

    2004-01-01

    Site-specific crop management or precision farming (PF) is a highly complex management system for site-specific input application of lime, fertilizers and pesticides in arable farming. The Global Positioning System (GPS) is the backbone of the system. To conduct PF several technical systems...

  8. Towards soft robotic devices for site-specific drug delivery.

    Science.gov (United States)

    Alici, Gursel

    2015-01-01

    Considerable research efforts have recently been dedicated to the establishment of various drug delivery systems (DDS) that are mechanical/physical, chemical and biological/molecular DDS. In this paper, we report on the recent advances in site-specific drug delivery (site-specific, controlled, targeted or smart drug delivery are terms used interchangeably in the literature, to mean to transport a drug or a therapeutic agent to a desired location within the body and release it as desired with negligibly small toxicity and side effect compared to classical drug administration means such as peroral, parenteral, transmucosal, topical and inhalation) based on mechanical/physical systems consisting of implantable and robotic drug delivery systems. While we specifically focus on the robotic or autonomous DDS, which can be reprogrammable and provide multiple doses of a drug at a required time and rate, we briefly cover the implanted DDS, which are well-developed relative to the robotic DDS, to highlight the design and performance requirements, and investigate issues associated with the robotic DDS. Critical research issues associated with both DDSs are presented to describe the research challenges ahead of us in order to establish soft robotic devices for clinical and biomedical applications.

  9. A summary of INSITE activities in tracking SKB's spent fuel repository site investigations from 2002-2009 and of advice provided to the regulatory authorities on the status of site understanding at the end of the surface-based investigations

    Energy Technology Data Exchange (ETDEWEB)

    Chapman, Neil (Chapman Consulting (Switzerland)); Bath, Adrian (Intellisci Ltd, (United Kingdom)); Geier, Joel (Clearwater Hardrock Consulting (United States)); Ove Stephansson (Steph Rock Consulting AB (Sweden)); Tiren, Sven (Geosigma (Sweden)); Tsang, Chin-Fu (Berkeley Geohydrophysics SP (United States))

    2010-11-15

    SSM and its predecessor SKI employed a team of earth scientists who followed and reviewed SKB's investigations of the potential spent nuclear fuel repository sites at Forsmark and Laxemar. This group was named INSITE (INdependent Site Investigation Tracking and Evaluation) and began its work in 2002 and completed its task with the review of the final versions SKB's site descriptive models, SDM-Site, in 2009. This report is a summary of INSITE's work over the eight-and-a-half year period of the site investigations and the lead-in and the wind-down to the work. It is intended to provide an outline and a record of how INSITE has worked and how its advice was generated and provided to SKI and, latterly, to SSM. Together with all the other documentation generated by INSITE, this report is intended to support the regulatory review of SKB's licence application for a spent nuclear fuel repository

  10. Site-Specific Infrared Probes of Proteins

    Science.gov (United States)

    Ma, Jianqiang; Pazos, Ileana M.; Zhang, Wenkai; Culik, Robert M.; Gai, Feng

    2015-01-01

    Infrared spectroscopy has played an instrumental role in studying a wide variety of biological questions. However, in many cases it is impossible or difficult to rely on the intrinsic vibrational modes of biological molecules of interest, such as proteins, to reveal structural and/or environmental information in a site-specific manner. To overcome this limitation, many recent efforts have been dedicated to the development and application of various extrinsic vibrational probes that can be incorporated into biological molecules and used to site-specifically interrogate their structural and/or environmental properties. In this Review, we highlight some recent advancements of this rapidly growing research area. PMID:25580624

  11. Preliminary site description Forsmark area - version 1.2

    Energy Technology Data Exchange (ETDEWEB)

    Skagius, Kristina [ed.

    2005-06-01

    The Swedish Nuclear Fuel and Waste Management Company (SKB) is undertaking site characterisation at two different locations, the Forsmark and Simpevarp areas, with the objective of siting a geological repository for spent nuclear fuel. An integrated component in the characterisation work is the development of a site descriptive model that constitutes a description of the site and its regional setting, covering the current state of the geosphere and the biosphere as well as those ongoing natural processes that affect their long-term evolution. The present report documents the site descriptive modelling activities (version 1.2) for the Forsmark area. The overall objectives of the version 1.2 site descriptive modelling are to produce and document an integrated description of the site and its regional environments based on the site-specific data available from the initial site investigations and to give recommendations on continued investigations. The modelling work is based on primary data, i.e. quality-assured, geoscientific and ecological field data available in the SKB databases SICADA and GIS, available July 31, 2004. The work has been conducted by a project group and associated discipline-specific working groups. The members of the project group represent the disciplines of geology, rock mechanics, thermal properties, hydrogeology, hydrogeochemistry, transport properties and surface ecosystems (including overburden, surface hydrogeochemistry and hydrology). In addition, some group members have specific qualifications of importance in this type of project e.g. expertise in RVS (Rock Visualisation System) modelling, GIS-modelling and in statistical data analysis. The overall strategy to achieve a site description is to develop discipline-specific models by interpretation and analyses of the primary data. The different discipline-specific models are then integrated into a site description. Methodologies for developing the discipline-specific models are documented in

  12. Preliminary site description Forsmark area - version 1.2

    International Nuclear Information System (INIS)

    Skagius, Kristina

    2005-06-01

    The Swedish Nuclear Fuel and Waste Management Company (SKB) is undertaking site characterisation at two different locations, the Forsmark and Simpevarp areas, with the objective of siting a geological repository for spent nuclear fuel. An integrated component in the characterisation work is the development of a site descriptive model that constitutes a description of the site and its regional setting, covering the current state of the geosphere and the biosphere as well as those ongoing natural processes that affect their long-term evolution. The present report documents the site descriptive modelling activities (version 1.2) for the Forsmark area. The overall objectives of the version 1.2 site descriptive modelling are to produce and document an integrated description of the site and its regional environments based on the site-specific data available from the initial site investigations and to give recommendations on continued investigations. The modelling work is based on primary data, i.e. quality-assured, geoscientific and ecological field data available in the SKB databases SICADA and GIS, available July 31, 2004. The work has been conducted by a project group and associated discipline-specific working groups. The members of the project group represent the disciplines of geology, rock mechanics, thermal properties, hydrogeology, hydrogeochemistry, transport properties and surface ecosystems (including overburden, surface hydrogeochemistry and hydrology). In addition, some group members have specific qualifications of importance in this type of project e.g. expertise in RVS (Rock Visualisation System) modelling, GIS-modelling and in statistical data analysis. The overall strategy to achieve a site description is to develop discipline-specific models by interpretation and analyses of the primary data. The different discipline-specific models are then integrated into a site description. Methodologies for developing the discipline-specific models are documented in

  13. 7 CFR 1948.83 - Performance of site development work.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 13 2010-01-01 2009-01-01 true Performance of site development work. 1948.83 Section 1948.83 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE... Development Assistance Program § 1948.83 Performance of site development work. Site development work will be...

  14. Investigation of tritium in groundwater at Site 300

    International Nuclear Information System (INIS)

    Buddemeier, R.W.

    1985-01-01

    In 1984, landfill monitoring wells at Site 300, a Lawrence Livermore National Laboratory (LLNL) explosive test site, revealed the presence of groundwater contaminated with tritium. These tritium levels were in excess of the State of California drinking water standard. A major investigation was initiated that included a search of records concerning tritium use, disposal, and previous analyses, and a survey of tritium levels in soil, vegetation, and water in contaminated and potentially contaminated areas. Over 50 boreholes were drilled for this investigation to characterize the local hydrogeology and tritium distributions, and a network of soil moisture and groundwater monitoring points was installed. This report presents the work completed through the end of September 1985: the records search; records for drilling completed as part of this study; characterization of the geology, hydrology, and tritium distributions in the contaminated area; and an initial assessment of the probable tritium sources, pathways, and migration rates. 19 refs

  15. Investigation of tritium in groundwater at Site 300

    Energy Technology Data Exchange (ETDEWEB)

    Buddemeier, R.W.

    1985-12-30

    In 1984, landfill monitoring wells at Site 300, a Lawrence Livermore National Laboratory (LLNL) explosive test site, revealed the presence of groundwater contaminated with tritium. These tritium levels were in excess of the State of California drinking water standard. A major investigation was initiated that included a search of records concerning tritium use, disposal, and previous analyses, and a survey of tritium levels in soil, vegetation, and water in contaminated and potentially contaminated areas. Over 50 boreholes were drilled for this investigation to characterize the local hydrogeology and tritium distributions, and a network of soil moisture and groundwater monitoring points was installed. This report presents the work completed through the end of September 1985: the records search; records for drilling completed as part of this study; characterization of the geology, hydrology, and tritium distributions in the contaminated area; and an initial assessment of the probable tritium sources, pathways, and migration rates. 19 refs.

  16. Web sites that work secrets from winning web sites

    CERN Document Server

    Smith, Jon

    2012-01-01

    Leading web site entrepreneur Jon Smith has condensed the secrets of his success into 52 inspiring ideas that even the most hopeless technophobe can implement. The brilliant tips and practical advice in Web sites that work will uplift and transform any website, from the simplest to the most complicated. It deals with everything from fundamentals such as how to assess the effectiveness of a website and how to get a site listed on the most popular search engines to more sophisticated challenges like creating a community and dealing with legal requirements. Straight-talking, practical and humorou

  17. Final work plan : phase I investigation of potential contamination at the former CCC/USDA grain storage facility in Montgomery City, Missouri.

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, L. M.; Environmental Science Division

    2010-08-16

    former grain storage facility, the CCC/USDA will conduct investigations to (1) characterize the source(s), extent, and factors controlling the possible subsurface distribution and movement of carbon tetrachloride at the Montgomery City site and (2) evaluate the health and environmental threats potentially represented by the contamination. This work will be performed in accord with the Intergovernmental Agreement established between the Farm Service Agency of the USDA and the MoDNR, to address carbon tetrachloride contamination potentially associated with a number of former CCC/USDA grain storage facilities in Missouri. The investigations at Montgomery City will be conducted on behalf of the CCC/USDA by the Environmental Science Division of Argonne National Laboratory. Argonne is a nonprofit, multidisciplinary research center operated by UChicago Argonne, LLC, for the U.S. Department of Energy (DOE). The CCC/USDA has entered into an agreement with DOE, under which Argonne provides technical assistance to the CCC/USDA with environmental site characterization and remediation at its former grain storage facilities. The site characterization at Montgomery City will take place in phases. This approach is recommended by the CCC/USDA and Argonne, so that information obtained and interpretations developed during each incremental stage of the investigation can be used most effectively to guide subsequent phases of the program. This site-specific Work Plan outlines the specific technical objectives and scope of work proposed for Phase I of the Montgomery City investigation. This Work Plan also includes the community relations plan to be followed throughout the CCC/USDA program at the Montgomery City site. Argonne is developing a Master Work Plan specific to operations in the state of Missouri. In the meantime, Argonne has issued a Provisional Master Work Plan (PMWP; Argonne 2007) that has been reviewed and approved by the MoDNR for current use. The PMWP (Argonne 2007) provides

  18. 78 FR 14088 - Environmental Management Site-Specific Advisory Board, Savannah River Site

    Science.gov (United States)

    2013-03-04

    ...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Savannah River Site. The Federal Advisory Committee Act requires that public notice of this meeting be announced in the Federal Register.

  19. A site-specific slurry application technique on grassland and on arable crops.

    Science.gov (United States)

    Schellberg, Jürgen; Lock, Reiner

    2009-01-01

    There is evidence that unequal slurry application on agricultural land contributes to N losses to the environment. Heterogeneity within fields demands adequate response by means of variable rate application. A technique is presented which allows site-specific application of slurry on grassland and arable land based on pre-defined application maps. The system contains a valve controlling flow rate by an on-board PC. During operation, flow rate is measured and scaled against set point values given in the application map together with the geographic position of the site. The systems worked sufficiently precise at a flow rate between 0 and 25 l s(-1) and an offset of actual slurry flow from set point values between 0.33 and 0.67 l s(-1). Long-term experimentation is required to test if site-specific application de facto reduces N surplus within fields and so significantly contributes to the unloading of N in agricultural areas.

  20. 75 FR 65310 - Environmental Management Site-Specific Advisory Board, Nevada

    Science.gov (United States)

    2010-10-22

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Nevada AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Nevada Test Site. The Federal Advisory... Board is to make recommendations to DOE-EM and site management in the areas of environmental restoration...

  1. A novel bench-scale column assay to investigate site-specific nitrification biokinetics in biological rapid sand filters

    DEFF Research Database (Denmark)

    Tatari, Karolina; Smets, Barth F.; Albrechtsen, Hans-Jørgen

    2013-01-01

    A bench-scale assay was developed to obtain site-specific nitrification biokinetic information from biological rapid sand filters employed in groundwater treatment. The experimental set-up uses granular material subsampled from a full-scale filter, packed in a column, and operated with controlled...

  2. Preliminary safety evaluation, based on initial site investigation data. Planning document

    International Nuclear Information System (INIS)

    Hedin, Allan

    2002-12-01

    This report is a planning document for the preliminary safety evaluations (PSE) to be carried out at the end of the initial stage of SKBs ongoing site investigations for a deep repository for spent nuclear fuel. The main purposes of the evaluations are to determine whether earlier judgements of the suitability of the candidate area for a deep repository with respect to long-term safety holds up in the light of borehole data and to provide feed-back to continued site investigations and site specific repository design. The preliminary safety evaluations will be carried out by a safety assessment group, based on a site model, being part of a site description, provided by a site modelling group and a repository layout within that model suggested by a repository engineering group. The site model contains the geometric features of the site as well as properties of the host rock. Several alternative interpretations of the site data will likely be suggested. Also the biosphere is included in the site model. A first task for the PSE will be to compare the rock properties described in the site model to previously established criteria for a suitable host rock. This report gives an example of such a comparison. In order to provide more detailed feedback, a number of thermal, hydrological, mechanical and chemical analyses of the site will also be included in the evaluation. The selection of analyses is derived from the set of geosphere and biosphere analyses preliminarily planned for the comprehensive safety assessment named SR-SITE, which will be based on a complete site investigation. The selection is dictated primarily by the expected feedback to continued site investigations and by the availability of data after the PSE. The repository engineering group will consider several safety related factors in suggesting a repository layout: Thermal calculations will be made to determine a minimum distance between canisters avoiding canister surface temperatures above 100 deg C

  3. FLP recombinase-mediated site-specific recombination in silkworm, Bombyx mori.

    Directory of Open Access Journals (Sweden)

    Ding-Pei Long

    Full Text Available A comprehensive understanding of gene function and the production of site-specific genetically modified mutants are two major goals of genetic engineering in the post-genomic era. Although site-specific recombination systems have been powerful tools for genome manipulation of many organisms, they have not yet been established for use in the manipulation of the silkworm Bombyx mori genome. In this study, we achieved site-specific excision of a target gene at predefined chromosomal sites in the silkworm using a FLP/FRT site-specific recombination system. We first constructed two stable transgenic target silkworm strains that both contain a single copy of the transgene construct comprising a target gene expression cassette flanked by FRT sites. Using pre-blastoderm microinjection of a FLP recombinase helper expression vector, 32 G3 site-specific recombinant transgenic individuals were isolated from five of 143 broods. The average frequency of FLP recombinase-mediated site-specific excision in the two target strains genome was approximately 3.5%. This study shows that it is feasible to achieve site-specific recombination in silkworms using the FLP/FRT system. We conclude that the FLP/FRT system is a useful tool for genome manipulation in the silkworm. Furthermore, this is the first reported use of the FLP/FRT system for the genetic manipulation of a lepidopteran genome and thus provides a useful reference for the establishment of genome manipulation technologies in other lepidopteran species.

  4. Execution programme for the initial site investigations at Forsmark

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-05-01

    In the feasibility studies that were completed in 2001, eight sites were identified as potentially suitable for hosting a repository. All the identified sites meet the safety requirements with respect to bedrock conditions that could be checked at that time. The feasibility studies have revealed good potential when it comes to the technical and environmental aspects as well. Based on an integrated evaluation SKB proposed to start site investigations with test drillings at three sites; Forsmark, Simpevarp and Tierp. Site investigations have started at Forsmark and Simpevarp. The municipal council of Tierp voted no to a site investigation in April 2002. The site investigations are divided into two main phases; initial and complete investigations. Initial site investigations are performed to identify the site within a specified area that is deemed to be most suitable for a deep repository and to determine whether the feasibility study's judgement of the suitability of the area holds up in the light of borehole data from repository depth. The initial site investigations are expected to take 1.5-2 years. If the assessment shows that the site has good potential to host a repository, complete site investigations will follow for an expected duration of 3.5-4 years. The purpose of the complete site investigations is to gather all information required to select one of the sites as the main alternative and to apply for a permit for construction of the deep repository at that site. A general programme in which the results from feasibility studies are summarized, the candidate sites presented and the framework of programme for the site investigation phase presented has been published. The general programme, and main references to the programme, specifies which data are required in order to design the repository and carry out a safety assessment, how the investigations should be carried out in order to provide these data, criteria with which the site must comply, as well as

  5. Execution programme for the initial site investigations at Forsmark

    International Nuclear Information System (INIS)

    2002-05-01

    In the feasibility studies that were completed in 2001, eight sites were identified as potentially suitable for hosting a repository. All the identified sites meet the safety requirements with respect to bedrock conditions that could be checked at that time. The feasibility studies have revealed good potential when it comes to the technical and environmental aspects as well. Based on an integrated evaluation SKB proposed to start site investigations with test drillings at three sites; Forsmark, Simpevarp and Tierp. Site investigations have started at Forsmark and Simpevarp. The municipal council of Tierp voted no to a site investigation in April 2002. The site investigations are divided into two main phases; initial and complete investigations. Initial site investigations are performed to identify the site within a specified area that is deemed to be most suitable for a deep repository and to determine whether the feasibility study's judgement of the suitability of the area holds up in the light of borehole data from repository depth. The initial site investigations are expected to take 1.5-2 years. If the assessment shows that the site has good potential to host a repository, complete site investigations will follow for an expected duration of 3.5-4 years. The purpose of the complete site investigations is to gather all information required to select one of the sites as the main alternative and to apply for a permit for construction of the deep repository at that site. A general programme in which the results from feasibility studies are summarized, the candidate sites presented and the framework of programme for the site investigation phase presented has been published. The general programme, and main references to the programme, specifies which data are required in order to design the repository and carry out a safety assessment, how the investigations should be carried out in order to provide these data, criteria with which the site must comply, as well as

  6. Salmon Site Remedial Investigation Report

    International Nuclear Information System (INIS)

    1999-01-01

    This Salmon Site Remedial Investigation Report provides the results of activities initiated by the U.S. Department of Energy (DOE) to determine if contamination at the Salmon Site poses a current or future risk to human health and the environment. These results were used to develop and evaluate a range of risk-based remedial alternatives. Located in Lamar County, Mississippi, the Salmon Site was used by the U.S. Atomic Energy Commission (predecessor to the DOE) between 1964 and 1970 for two nuclear and two gas explosions conducted deep underground in a salt dome. The testing resulted in the release of radionuclides into the salt dome. During reentry drilling and other site activities, liquid and solid wastes containing radioactivity were generated resulting in surface soil and groundwater contamination. Most of the waste and contaminated soil and water were disposed of in 1993 during site restoration either in the cavities left by the tests or in an injection well. Other radioactive wastes were transported to the Nevada Test Site for disposal. Nonradioactive wastes were disposed of in pits at the site and capped with clean soil and graded. The preliminary investigation showed residual contamination in the Surface Ground Zero mud pits below the water table. Remedial investigations results concluded the contaminant concentrations detected present no significant risk to existing and/or future land users, if surface institutional controls and subsurface restrictions are maintained. Recent sampling results determined no significant contamination in the surface or shallow subsurface. The test cavity resulting from the experiments is contaminated and cannot be economically remediated with existing technologies. The ecological sampling did not detect biological uptake of contaminants in the plants or animals sampled. Based on the current use of the Salmon Site, the following remedial actions were identified to protect both human health and the environment: (1) the

  7. Investigations on site suitability for a final repository of low-and intermediate-level radioactive wastes. Status report of phase I investigations for the feasible Bois de la Glaive site (community of Ollon, VD)

    International Nuclear Information System (INIS)

    1988-10-01

    On 30 th September 1985, site suitability investigations with a view to disposal of low- and intermediate-level radioactive waste were licensed by the Federal Government at three locations - Bois de la Glaive (Canton Vaud), Oberbauenstock (Canton Uri) and Piz Pian Grand (Canton Graubuenden). This report presents the status of the investigations at Bois de la Glaive as at the end of 1987 and discusses the results of the programme. Because of the opposition of the community of Ollon, none of the investigations subject to authorization have been carried out, even though these investigations had been approved by the Federal Government on 30 th September 1985. Nevertheless, various investigations not requiring a license have provided a considerable store of data. The details of the work actually carried out are as follows: (1) Detailed geological mapping of the earth's surface over an area of 22.5 km 2 on a scale of 1:5000. This study included the first geological recording of the Galerie de Salin (Salin drift) which formed part of an 18 th -century mine. (2) The existing hydrogeological data on the area were compiled and provided a first impression of the overall hydrogeological conditions. (3) The provisional concept of a possible repository at Bois de la Glaive and of the corresponding exploration gallery was elaborated under the point of view of civil engineering and the long-term behaviour of the host rock was assessed qualitatively. To summarize, based on the present stage of the investigations and on rock- resp. site-specific knowledge of the anhydrite as a host rock, there are no real reasons for ruling out the site. 54 refs., 11 figs

  8. 78 FR 26005 - Environmental Management Site-Specific Advisory Board, Savannah River Site

    Science.gov (United States)

    2013-05-03

    ...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Savannah River Site. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770) requires that public notice of this meeting be announced in the Federal Register.

  9. 78 FR 65979 - Environmental Management Site-Specific Advisory Board, Savannah River Site

    Science.gov (United States)

    2013-11-04

    ...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Savannah River Site. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770) requires that public notice of this meeting be announced in the Federal Register.

  10. 77 FR 24695 - Environmental Management Site-Specific Advisory Board, Savannah River Site

    Science.gov (United States)

    2012-04-25

    ...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Savannah River Site. The Federal Advisory Committee Act (Pub. L. . 92-463, 86 Stat. 770) requires that public notice of this meeting be announced in the Federal Register.

  11. 77 FR 60688 - Environmental Management Site-Specific Advisory Board, Savannah River Site

    Science.gov (United States)

    2012-10-04

    ...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Savannah River Site. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770) requires that public notice of this meeting be announced in the Federal Register.

  12. 77 FR 13104 - Environmental Management Site-Specific Advisory Board, Savannah River Site

    Science.gov (United States)

    2012-03-05

    ...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Savannah River Site. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770) requires that public notice of this meeting be announced in the Federal Register.

  13. 77 FR 39235 - Environmental Management Site-Specific Advisory Board, Savannah River Site

    Science.gov (United States)

    2012-07-02

    ...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Savannah River Site. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770) requires that public notice of this meeting be announced in the Federal Register.

  14. 78 FR 716 - Environmental Management Site-Specific Advisory Board, Savannah River Site

    Science.gov (United States)

    2013-01-04

    ...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Savannah River Site. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770) requires that public notice of this meeting be announced in the Federal Register.

  15. 78 FR 54461 - Environmental Management Site-Specific Advisory Board, Savannah River Site

    Science.gov (United States)

    2013-09-04

    ...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Savannah River Site. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770) requires that public notice of this meeting be announced in the Federal Register.

  16. 77 FR 53193 - Environmental Management Site-Specific Advisory Board, Savannah River Site

    Science.gov (United States)

    2012-08-31

    ...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Savannah River Site. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770) requires that public notice of this meeting be announced in the Federal Register.

  17. 78 FR 40130 - Environmental Management Site-Specific Advisory Board, Savannah River Site

    Science.gov (United States)

    2013-07-03

    ...This notice announces a meeting of the Environmental Management Site-Specific Advisory Board (EM SSAB), Savannah River Site. The Federal Advisory Committee Act (Pub. L. No. 92-463, 86 Stat. 770) requires that public notice of this meeting be announced in the Federal Register.

  18. 78 FR 16260 - Environmental Management Site-Specific Advisory Board, Savannah River Site

    Science.gov (United States)

    2013-03-14

    ...On March 4, 2013, the Department of Energy (DOE) published a notice of open meeting announcing a meeting on March 25-26, 2013 of the Environmental Management Site-Specific Advisory Board, Savannah River Site (78 FR 14088). This document makes a correction to that notice.

  19. 75 FR 6018 - Environmental Management Site-Specific Advisory Board, Hanford

    Science.gov (United States)

    2010-02-05

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Hanford AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Hanford (known locally as the Hanford Advisory... and site management in the areas of environmental restoration, waste management, and related...

  20. Corrective Action Investigation Plan for Corrective Action Unit 137: Waste Disposal Sites, Nevada Test Site, Nevada, Rev. No.:0

    Energy Technology Data Exchange (ETDEWEB)

    Wickline, Alfred

    2005-12-01

    This Corrective Action Investigation Plan (CAIP) contains project-specific information including facility descriptions, environmental sample collection objectives, and criteria for conducting site investigation activities at Corrective Action Unit (CAU) 137: Waste Disposal Sites. This CAIP has been developed in accordance with the ''Federal Facility Agreement and Consent Order'' (FFACO) (1996) that was agreed to by the State of Nevada, the U.S. Department of Energy (DOE), and the U.S. Department of Defense. Corrective Action Unit 137 contains sites that are located in Areas 1, 3, 7, 9, and 12 of the Nevada Test Site (NTS), which is approximately 65 miles (mi) northwest of Las Vegas, Nevada (Figure 1-1). Corrective Action Unit 137 is comprised of the eight corrective action sites (CASs) shown on Figure 1-1 and listed below: (1) CAS 01-08-01, Waste Disposal Site; (2) CAS 03-23-01, Waste Disposal Site; (3) CAS 03-23-07, Radioactive Waste Disposal Site; (4) CAS 03-99-15, Waste Disposal Site; (5) CAS 07-23-02, Radioactive Waste Disposal Site; (6) CAS 09-23-07, Radioactive Waste Disposal Site; (7) CAS 12-08-01, Waste Disposal Site; and (8) CAS 12-23-07, Waste Disposal Site. The Corrective Action Investigation (CAI) will include field inspections, radiological surveys, geophysical surveys, sampling of environmental media, analysis of samples, and assessment of investigation results, where appropriate. Data will be obtained to support corrective action alternative evaluations and waste management decisions. The CASs in CAU 137 are being investigated because hazardous and/or radioactive constituents may be present in concentrations that could potentially pose a threat to human health and the environment. Existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives for the CASs. Additional information will be generated by conducting a CAI before evaluating and selecting

  1. 76 FR 5147 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2011-01-28

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management and...

  2. 77 FR 59598 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2012-09-28

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management and...

  3. 75 FR 13269 - Environmental Management Site-Specific Advisory Board, Hanford

    Science.gov (United States)

    2010-03-19

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Hanford AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Hanford. The Federal Advisory Committee Act... is to make recommendations to DOE-EM and site management in the areas of environmental restoration...

  4. 75 FR 54600 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2010-09-08

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management and...

  5. 75 FR 66074 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2010-10-27

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management and...

  6. 75 FR 8050 - Environmental Management Site-Specific Advisory Board, Hanford

    Science.gov (United States)

    2010-02-23

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Hanford AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Hanford. The Federal Advisory Committee Act... is to make recommendations to DOE-EM and site management in the areas of environmental restoration...

  7. 75 FR 24686 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2010-05-05

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management and...

  8. 76 FR 80355 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2011-12-23

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... make recommendations to DOE-EM and site management in the areas of environmental restoration, waste...

  9. 75 FR 9404 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2010-03-02

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management and...

  10. 75 FR 56526 - Environmental Management Site-Specific Advisory Board, Portsmouth

    Science.gov (United States)

    2010-09-16

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Portsmouth AGENCY... Initiative Workshop of the Environmental Management Site-Specific Advisory Board (EM SSAB), Portsmouth. The... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management and...

  11. 77 FR 43583 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2012-07-25

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management and...

  12. 75 FR 61711 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2010-10-06

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management and...

  13. 75 FR 82002 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2010-12-29

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management and...

  14. 76 FR 61350 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2011-10-04

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... make recommendations to DOE-EM and site management in the areas of environmental restoration, waste...

  15. 76 FR 4645 - Environmental Management Site-Specific Advisory Board, Hanford

    Science.gov (United States)

    2011-01-26

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Hanford AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Hanford. The Federal Advisory Committee Act... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management, and...

  16. 76 FR 48148 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2011-08-08

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management and...

  17. 75 FR 82004 - Environmental Management Site-Specific Advisory Board, Nevada

    Science.gov (United States)

    2010-12-29

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Nevada AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Nevada. The Federal Advisory Committee Act (Pub... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management, and...

  18. 77 FR 4027 - Environmental Management Site-Specific Advisory Board, Nevada

    Science.gov (United States)

    2012-01-26

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Nevada AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Nevada. The Federal Advisory Committee Act (Pub... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management, and...

  19. 76 FR 80354 - Environmental Management Site-Specific Advisory Board, Nevada

    Science.gov (United States)

    2011-12-23

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Nevada AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Nevada. The Federal Advisory Committee Act (Pub... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management, and...

  20. 77 FR 12044 - Environmental Management Site-Specific Advisory Board, Nevada

    Science.gov (United States)

    2012-02-28

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Nevada AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Nevada. The Federal Advisory Committee Act (Pub... Board is to make recommendations to DOE-EM and site management in the areas of environmental restoration...

  1. New developments for the site-specific attachment of protein to surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Camarero, J A

    2005-05-12

    Protein immobilization on surfaces is of great importance in numerous applications in biology and biophysics. The key for the success of all these applications relies on the immobilization technique employed to attach the protein to the corresponding surface. Protein immobilization can be based on covalent or noncovalent interaction of the molecule with the surface. Noncovalent interactions include hydrophobic interactions, hydrogen bonding, van der Waals forces, electrostatic forces, or physical adsorption. However, since these interactions are weak, the molecules can get denatured or dislodged, thus causing loss of signal. They also result in random attachment of the protein to the surface. Site-specific covalent attachment of proteins onto surfaces, on the other hand, leads to molecules being arranged in a definite, orderly fashion and uses spacers and linkers to help minimize steric hindrances between the protein surface. This work reviews in detail some of the methods most commonly used as well as the latest developments for the site-specific covalent attachment of protein to solid surfaces.

  2. Hydrogeological Site Descriptive Model - a strategy for its development during Site Investigations

    Energy Technology Data Exchange (ETDEWEB)

    Rhen, Ingvar [SWECO VIAK AB, Goeteborg (Sweden); Follin, Sven [SF GeoLogic AB, Stockholm (Sweden); Hermanson, Jan [Golder Associates, Stockholm (Sweden)

    2003-04-01

    The report is to present a strategy for the development of the Site Descriptive Hydrogeological Model within the SKB Site Investigation Programme. The report, and similar reports from the Geology, Rock Mechanics, Thermal properties, Hydrogeochemistry, Transport Properties and Surface Ecosystem disciplines are intended to guide SKB Site Descriptive Modelling but also to provide the authorities with an overview of how the modelling should be performed. Thus the objectives of this report are to: provide guidelines for the modelling of different sites resulting in consistent handling of modelling issues during the Site Investigations, provide a structure for the modelling sequence that is suitable for the establishment of a Site Descriptive model and provide some necessary details that should be considered in a Site Descriptive model.

  3. Hydrogeological Site Descriptive Model - a strategy for its development during Site Investigations

    International Nuclear Information System (INIS)

    Rhen, Ingvar; Follin, Sven; Hermanson, Jan

    2003-04-01

    The report is to present a strategy for the development of the Site Descriptive Hydrogeological Model within the SKB Site Investigation Programme. The report, and similar reports from the Geology, Rock Mechanics, Thermal properties, Hydrogeochemistry, Transport Properties and Surface Ecosystem disciplines are intended to guide SKB Site Descriptive Modelling but also to provide the authorities with an overview of how the modelling should be performed. Thus the objectives of this report are to: provide guidelines for the modelling of different sites resulting in consistent handling of modelling issues during the Site Investigations, provide a structure for the modelling sequence that is suitable for the establishment of a Site Descriptive model and provide some necessary details that should be considered in a Site Descriptive model

  4. Remedial Investigation Work Plan for Upper East Fork Poplar Creek Operable Unit 3 at the Oak Ridge Y-12 Plant, Oak Ridge, Tennessee

    International Nuclear Information System (INIS)

    1993-08-01

    Upper East Fork Popular Creek Operable Unit 3 (UEFPC OU 3) is a source term OU composed of seven sites, and is located in the western portion of the Y-12 Plant. For the most part, the UEFPC OU 3 sites served unrelated purposes and are geographically removed from one another. The seven sites include the following: Building 81-10, the S-2 Site, Salvage Yard oil storage tanks, the Salvage Yard oil/solvent drum storage area, Tank Site 2063-U, the Salvage Yard drum deheader, and the Salvage Yard scrap metal storage area. All of these sites are contaminated with at least one or more hazardous and/or radioactive chemicals. All sites have had some previous investigation under the Y-12 Plant RCRA Program. The work plan contains summaries of geographical, historical, operational, geological, and hydrological information specific to each OU 3 site. The potential for release of contaminants to receptors through various media is addressed, and a sampling and analysis plan is presented to obtain objectives for the remedial investigation. Proposed sampling activities are contingent upon the screening level risk assessment, which includes shallow soil sampling, soil borings, monitoring well installation, groundwater sampling, and surface water sampling. Data from the site characterization activities will be used to meet the above objectives. A Field Sampling Investigation Plan, Health and Safety Plan, and Waste Management Plan are also included in this work plan

  5. An investigation of the universe and anatomy of work

    OpenAIRE

    Beruvides, Mario G

    1993-01-01

    This research study investigated eight specific work characteristics (outputs, inputs, work type, discretion level, work pursuit level, level of endeavor, decision type and maturity level), on three sub-populations of workers (production personnel, office/secretarial personnel, and university engineering professors). Thirty one production personnel from two organizations (the Print Shop and ABC Corporation-pseudonyms) located in southwest Virginia were used for the first group (B group). The...

  6. Does work-site physical activity improve self-reported psychosocial workplace factors and job satisfaction?

    DEFF Research Database (Denmark)

    Roessler, K K; Rugulies, R; Bilberg, R

    2013-01-01

    PURPOSE: To investigate whether a work-site strength-training program has a positive effect on self-reported psychosocial workplace factors and job satisfaction. METHODS: We conducted a randomized controlled trial among laboratory technicians implementing neck and shoulder exercises for pain relief......, with 199 participants in the training group and 228 in the control group. Influence at work, sense of community, time pressure, and job satisfaction were measured with the Copenhagen Psychosocial Questionnaire at baseline and post-intervention after 20 weeks. RESULTS: There was no statistically significant...... of a work-site strength-training program on self-reported psychosocial workplace factors and job satisfaction....

  7. Site Specific Probable Maximum Precipitation Estimates and Professional Judgement

    Science.gov (United States)

    Hayes, B. D.; Kao, S. C.; Kanney, J. F.; Quinlan, K. R.; DeNeale, S. T.

    2015-12-01

    State and federal regulatory authorities currently rely upon the US National Weather Service Hydrometeorological Reports (HMRs) to determine probable maximum precipitation (PMP) estimates (i.e., rainfall depths and durations) for estimating flooding hazards for relatively broad regions in the US. PMP estimates for the contributing watersheds upstream of vulnerable facilities are used to estimate riverine flooding hazards while site-specific estimates for small water sheds are appropriate for individual facilities such as nuclear power plants. The HMRs are often criticized due to their limitations on basin size, questionable applicability in regions affected by orographic effects, their lack of consist methods, and generally by their age. HMR-51 for generalized PMP estimates for the United States east of the 105th meridian, was published in 1978 and is sometimes perceived as overly conservative. The US Nuclear Regulatory Commission (NRC), is currently reviewing several flood hazard evaluation reports that rely on site specific PMP estimates that have been commercially developed. As such, NRC has recently investigated key areas of expert judgement via a generic audit and one in-depth site specific review as they relate to identifying and quantifying actual and potential storm moisture sources, determining storm transposition limits, and adjusting available moisture during storm transposition. Though much of the approach reviewed was considered a logical extension of HMRs, two key points of expert judgement stood out for further in-depth review. The first relates primarily to small storms and the use of a heuristic for storm representative dew point adjustment developed for the Electric Power Research Institute by North American Weather Consultants in 1993 in order to harmonize historic storms for which only 12 hour dew point data was available with more recent storms in a single database. The second issue relates to the use of climatological averages for spatially

  8. Site-Specific Waste Management Instruction - 100-DR-1 Group 2 Sites

    International Nuclear Information System (INIS)

    Jackson, R.W.

    1998-01-01

    This site-specific waste management instruction (SSWMI) provides guidance for the management of wastes that may be generated during the excavation and remediation of the 100-DR-1 Group 2 sites. The management of waste generated as a result of these activities will be as directed in this SSWMI. This SSWMI will be revised to incorporate guidance for management of wastes encountered that are not addressed in this SSWMI

  9. Site Specific Ground Response Analysis for Quantifying Site Amplification at A Regolith Site

    Directory of Open Access Journals (Sweden)

    Bambang Setiawan

    2017-08-01

    Full Text Available DOI: 10.17014/ijog.4.3.159-167A numerical model has demonstrated that it can simulate reasonably well earthquake motions at the ground level during a seismic event. The most widely used model is an equivalent linear approach. The equivalent linear model was used to compute the free-field response of Adelaide regolith during the 1997 Burra earthquake. The aim of this study is to quantify the amplification at the investigated site. The model computed the ground response of horizontally layered soil deposits subjected to transient and vertically propagating shear waves through a one-dimensional-soil column. Each soil layer was assumed to be homogeneous, visco-elastic, and infinite in the horizontal extent. The results of this study were compared to other studies and forward computation of the geotechnical dynamic parameters of the investigated site. The amplification triggered by the 1997 Burra seismic event was deduced. This study reveals the amplification factor up to 3.6 at the studied site.

  10. Preliminary safety evaluation for the Simpevarp subarea. Based on data and site descriptions after the initial site investigation stage

    International Nuclear Information System (INIS)

    2005-04-01

    The main objectives of this Preliminary safety evaluation (PSE) of the Simpevarp subarea are: to determine, whether the feasibility study's judgement of the suitability of the candidate area with respect to long-term safety holds up in the light of the site investigation data; to provide feedback to continued site investigations and site-specific repository design and to identify site specific scenarios and geoscientific issues for further analyses. The PSE focuses on comparing the attained knowledge of the sites with the suitability criteria as set out by SKB in the report SKB-TR--00-12. These criteria both concern properties of the site judged to be necessary for safety and engineering (requirements) and properties judged to be beneficial (preferences). The findings are then evaluated in order to provide feedback to continued investigations and design work. The PSE does not aim at comparing sites and does not assess compliance with safety and radiation protection criteria. The evaluation shows that even considering remaining uncertainties, the Simpevarp subarea meets all safety requirements and most of the safety preferences. Consequently, from a safety point of view, there is no reason not to continue the Site Investigations of the Simpevarp subarea. There are still uncertainties to resolve and the safety would eventually need to be verified through a full safety assessment. Still, this Preliminary Safety Evaluation demonstrates that it is likely that a safe repository for spent nuclear fuel of the KBS-3 type could be constructed at the site. The following feedback is provided to the site investigations and the associated site modelling: Reducing the uncertainty on the deformation zone geometry within the Simpevarp subarea would allow for a more specified layout, although the sensitivity analysis shows that the space needed is rather robust with respect to uncertainties in the zones. There is substantial uncertainty in the discrete fracture network (DFN) model

  11. Site investigations for repositories for solid radioactive wastes in deep continental geological formations

    International Nuclear Information System (INIS)

    1982-01-01

    This report reviews the earth-science investigations and associated scientific studies that may be needed to select a repository site and confirm that its characteristics are such that it will provide a safe confinement for solidified high-level and alpha-bearing and certain other solid radioactive wastes. Site investigations, as used in this report, cover earth sciences and associated safety analyses. Other site-investigation activities are identified but not otherwise considered here. The repositories under consideration are those consisting of mined cavities in deep continental rocks for accepting wastes in the solid and packaged form. The term deep as used in this report is used solely to emphasize the distinction between the repositories discussed in this report and those for shallow-ground disposal. In general, depths under consideration here are greater than 200 metres. The term continental refers to those geological formations that occur either beneath present-day land masses and adjoining islands or beneath the shallow seas. One of the objectives of site investigations is to collect the site-specific data necessary for the different evaluations, such as modelling required to assess the long-term safety of an underground repository

  12. Site investigations for repositories for solid radioactive wastes in deep continental geological formations

    Energy Technology Data Exchange (ETDEWEB)

    1982-01-01

    This report reviews the earth-science investigations and associated scientific studies that may be needed to select a repository site and confirm that its characteristics are such that it will provide a safe confinement for solidified high-level and alpha-bearing and certain other solid radioactive wastes. Site investigations, as used in this report, cover earth sciences and associated safety analyses. Other site-investigation activities are identified but not otherwise considered here. The repositories under consideration are those consisting of mined cavities in deep continental rocks for accepting wastes in the solid and packaged form. The term deep as used in this report is used solely to emphasize the distinction between the repositories discussed in this report and those for shallow-ground disposal. In general, depths under consideration here are greater than 200 metres. The term continental refers to those geological formations that occur either beneath present-day land masses and adjoining islands or beneath the shallow seas. One of the objectives of site investigations is to collect the site-specific data necessary for the different evaluations, such as modelling required to assess the long-term safety of an underground repository.

  13. Site-specific fragmentation of polystyrene molecule using size-selected Ar gas cluster ion beam

    International Nuclear Information System (INIS)

    Moritani, Kousuke; Mukai, Gen; Hashinokuchi, Michihiro; Mochiji, Kozo

    2009-01-01

    The secondary ion mass spectrum (SIMS) of a polystyrene thin film was investigated using a size-selected Ar gas cluster ion beam (GCIB). The fragmentation in the SIM spectrum varied by kinetic energy per atom (E atom ); the E atom dependence of the secondary ion intensity of the fragment species of polystyrene can be essentially classified into three types based on the relationship between E atom and the dissociation energy of a specific bonding site in the molecule. These results indicate that adjusting E atom of size-selected GCIB may realize site-specific bond breaking within a molecule. (author)

  14. Final work plan : Phase I investigation of potential contamination at the former CCC/USDA grain storage facility in Savannah, Missouri.

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, L. M.; Environmental Science Division

    2007-10-12

    . This work will be performed in accord with the Intergovernmental Agreement established between the Farm Service Agency of the USDA and MoDNR, to address carbon tetrachloride contamination potentially associated with a number of former CCC/USDA grain storage facilities in Missouri. The investigative activities at Savannah will be conducted on behalf of the CCC/USDA by the Environmental Science Division of Argonne National Laboratory. Argonne is a nonprofit, multidisciplinary research center operated by UChicago Argonne, LLC, for the U.S. Department of Energy (DOE). The CCC/USDA has entered into an agreement with the DOE, under which Argonne provides technical assistance to the CCC/USDA with environmental site characterization and remediation at its former grain storage facilities. The site characterization at Savannah will take place in phases. This approach is recommended by the CCC/USDA and Argonne, so that information obtained and interpretations developed during each incremental stage of the investigation can be used most effectively to guide subsequent phases of the program. This site-specific Work Plan outlines the specific technical objectives and scope of work proposed for Phase I of the Savannah investigation. This Work Plan also includes the community relations plan to be followed throughout the CCC/USDA program at the Savannah site. Argonne is developing a Master Work Plan specific to operations in the state of Missouri. In the meantime, Argonne will issue a Provisional Master Work Plan (PMWP; Argonne 2007) that will be submitted to the MoDNR for review and approval. The agency has already reviewed and approved (with minor changes) the present Master Work Plan (Argonne 2002) under which Argonne currently operates in Kansas. The PMWP (Argonne 2007) will provide detailed information and guidance on the investigative technologies, analytical methodologies, quality assurance-quality control measures, and general health and safety policies to be employed by

  15. Strategy for the use of laboratory methods in the site investigations programme for the transport properties of the rock

    International Nuclear Information System (INIS)

    Widestrand, Henrik; Byegaard, Johan; Ohlsson, Yvonne; Tullborg, Eva-Lena

    2003-06-01

    This report comprises a strategy for the handling of laboratory investigations of diffusivity and sorption characteristics within the discipline-specific programme 'Transport Properties of the Rock' in the SKB site investigations. The aim of the transport programme is to investigate the solute transport properties at a site in order to acquire data that are required for an assessment of the long-term performance and radiological safety of the deep repository. The result of the transport programme is the Transport Properties Site Descriptive Model, i.e. a description of the site-specific properties for the transport of solutes in the groundwater at a site. A strategy for the methodology, control of sampling and characterisation programme and interpretation of the results, is proposed. The basis for the laboratory investigations is a conceptual geological model based on the geological model produced in the geology programme. Major and minor types of rock and fractures are defined and characterised according to the quality of the general database and site-specific needs. The selection of samples and analyses is determined in close co-operation with the geology, hydrogeology, hydrogeochemistry and rock mechanics programmes. The result of the laboratory investigations is a retardation model, which is used as an input in the Transport Properties Site Descriptive Model. The interpretation and production of a retardation model is described and exemplified. Lastly, method-specific strategies and recommendations are given, including strategies for the selection of tracers in the experiments and for the treatment of the sampled geologic materials

  16. Strategy for the use of laboratory methods in the site investigations programme for the transport properties of the rock

    Energy Technology Data Exchange (ETDEWEB)

    Widestrand, Henrik; Byegaard, Johan [Geosigma AB, Kungaelv (Sweden); Ohlsson, Yvonne [SWECO VIAK AB, Stockholm (Sweden); Tullborg, Eva-Lena [Terralogica AB, Graabo (Sweden)

    2003-06-01

    This report comprises a strategy for the handling of laboratory investigations of diffusivity and sorption characteristics within the discipline-specific programme 'Transport Properties of the Rock' in the SKB site investigations. The aim of the transport programme is to investigate the solute transport properties at a site in order to acquire data that are required for an assessment of the long-term performance and radiological safety of the deep repository. The result of the transport programme is the Transport Properties Site Descriptive Model, i.e. a description of the site-specific properties for the transport of solutes in the groundwater at a site. A strategy for the methodology, control of sampling and characterisation programme and interpretation of the results, is proposed. The basis for the laboratory investigations is a conceptual geological model based on the geological model produced in the geology programme. Major and minor types of rock and fractures are defined and characterised according to the quality of the general database and site-specific needs. The selection of samples and analyses is determined in close co-operation with the geology, hydrogeology, hydrogeochemistry and rock mechanics programmes. The result of the laboratory investigations is a retardation model, which is used as an input in the Transport Properties Site Descriptive Model. The interpretation and production of a retardation model is described and exemplified. Lastly, method-specific strategies and recommendations are given, including strategies for the selection of tracers in the experiments and for the treatment of the sampled geologic materials.

  17. Levels of processing and language modality specificity in working memory.

    Science.gov (United States)

    Rudner, Mary; Karlsson, Thomas; Gunnarsson, Johan; Rönnberg, Jerker

    2013-03-01

    Neural networks underpinning working memory demonstrate sign language specific components possibly related to differences in temporary storage mechanisms. A processing approach to memory systems suggests that the organisation of memory storage is related to type of memory processing as well. In the present study, we investigated for the first time semantic, phonological and orthographic processing in working memory for sign- and speech-based language. During fMRI we administered a picture-based 2-back working memory task with Semantic, Phonological, Orthographic and Baseline conditions to 11 deaf signers and 20 hearing non-signers. Behavioural data showed poorer and slower performance for both groups in Phonological and Orthographic conditions than in the Semantic condition, in line with depth-of-processing theory. An exclusive masking procedure revealed distinct sign-specific neural networks supporting working memory components at all three levels of processing. The overall pattern of sign-specific activations may reflect a relative intermodality difference in the relationship between phonology and semantics influencing working memory storage and processing. Copyright © 2012 Elsevier Ltd. All rights reserved.

  18. Site specific study for possible ongoing salt dome movement

    International Nuclear Information System (INIS)

    Thoms, R.L.; Manning, T.A.; Paille, L.K.; Gehle, R.M.

    1977-01-01

    U.S. Gulf Coast salt domes, among other geologic structures, currently are being considered for storage of commercial radioactive wastes. A major concern with dome storage of long lived radioactive wastes lies with the possible tectonic movement of the host dome. Any ongoing movement of a salt dome can be monitored with a site specific complementary system of field instrumentation and finite element modelling. Field instrumentation and accompanying finite element analyses for a study dome in northwest Louisiana are described. Site specific data and early experience associated with tiltmeters over the dome are presented. Also, recommendations are made for modifications and extensions of the field instrumentation and finite element modelling appropriate to the specific site under study

  19. Quantitative chemoproteomics for site-specific analysis of protein alkylation by 4-hydroxy-2-nonenal in cells.

    Science.gov (United States)

    Yang, Jing; Tallman, Keri A; Porter, Ned A; Liebler, Daniel C

    2015-03-03

    Protein alkylation by 4-hydroxy-2-nonenal (HNE), an endogenous lipid derived electrophile, contributes to stress signaling and cellular toxicity. Although previous work has identified protein targets for HNE alkylation, the sequence specificity of alkylation and dynamics in a cellular context remain largely unexplored. We developed a new quantitative chemoproteomic platform, which uses isotopically tagged, photocleavable azido-biotin reagents to selectively capture and quantify the cellular targets labeled by the alkynyl analogue of HNE (aHNE). Our analyses site-specifically identified and quantified 398 aHNE protein alkylation events (386 cysteine sites and 12 histidine sites) in intact cells. This data set expands by at least an order of magnitude the number of such modification sites previously reported. Although adducts formed by Michael addition are thought to be largely irreversible, we found that most aHNE modifications are lost rapidly in situ. Moreover, aHNE adduct turnover occurs only in intact cells and loss rates are site-selective. This quantitative chemoproteomics platform provides a versatile general approach to map bioorthogonal-chemically engineered post-translational modifications and their cellular dynamics in a site-specific and unbiased manner.

  20. Small Scale Multisource Site – Hydrogeology Investigation

    Science.gov (United States)

    A site impacted by brackish water was evaluated using traditional hydrogeologic and geochemical site characterization techniques. No single, specific source of the brine impacted ground water was identified. However, the extent of the brine impacted ground water was found to be...

  1. Status of initial phase of site-specific seismic monitoring: Basalt Waste Isolation Project

    International Nuclear Information System (INIS)

    Rohay, A.C.

    1981-01-01

    This report presents the status of the initial phase of site-specific seismic monitoring work conducted under the Basalt Waste Isolation Project. This work is currently organized under two main elements: (1) a portable array; and (2) a baseline data collection array. Progress toward the development of each array is discussed along with an interpretation of preliminary data obtained from the test of a borehole seismometer at potential repository depths. The text is supplemented by nine figures and one table. 9 figs., 1 tab

  2. Savannah River Site's Site Specific Plan

    Energy Technology Data Exchange (ETDEWEB)

    1991-08-01

    This Site Specific Plan (SSP) has been prepared by the Savannah River Site (SRS) in order to show the Environmental Restoration and Waste Management activities that were identified during the preparation of the Department of Energy-Headquarters (DOE-HQ) Environmental Restoration and Waste Management Five-Year Plan (FYP) for FY 1992--1996. The SSP has been prepared in accordance with guidance received from DOE-HQ. DOE-SR is accountable to DOE-HQ for the implementation of this plan. The purpose of the SSP is to develop a baseline for policy, budget, and schedules for the DOE Environmental Restoration and Waste Management activities. The plan explains accomplishments since the Fiscal Year (FY) 1990 plan, demonstrates how present and future activities are prioritized, identifies currently funded activities and activities that are planned to be funded in the upcoming fiscal year, and describes future activities that SRS is considering.

  3. Site-specific programming of the host epithelial transcriptome by the gut microbiota

    DEFF Research Database (Denmark)

    Sommer, Felix; Nookaew, Intawat; Sommer, Nina

    2015-01-01

    BACKGROUND: The intestinal epithelium separates us from the microbiota but also interacts with it and thus affects host immune status and physiology. Previous studies investigated microbiota-induced responses in the gut using intact tissues or unfractionated epithelial cells, thereby limiting....... The microbial impact on host gene expression was highly site specific, as epithelial responses to the microbiota differed between cell fractions. Specific transcriptional regulators were enriched in each fraction. In general, the gut microbiota induced a more rapid response in the colon than in the ileum...

  4. 76 FR 55370 - Environmental Management Site-Specific Advisory Board, Nevada

    Science.gov (United States)

    2011-09-07

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Nevada AGENCY...-Wide Environmental Impact Statement (EIS) Committee of the Environmental Management Site- Specific... the areas of environmental restoration, waste management, and related activities. Purpose of the...

  5. Final disposal of spent fuel in the Finnish bedrock. Scope and requirements for site-specific safety analysis; Kaeytetyn polttoaineen loppusijoitus Suomen kallioperaeaen. Paikkakohtaisen turvallisuusanalyysin edellytykset ja mahdollisuudet

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-01

    The report is a summary of the research conducted in the period 1993 to 1996 into safety of spent fuel final disposal. The principal goal of the research in this period, as set in 1993, was to develop a strategy for site-specific safety analysis. At the same time efforts were to be continued to gather data and validate the technical approach for the analysis. The work aimed at having the data needed for the analysis available at the end of year 1998. A safety assessment update, TILA-96, prepared by VTT Energy, is published as a separate report. The assessment is based on the TVO-92 safety analysis, but takes into account the knowledge acquired after 1992 on safety aspects of the disposal system and the data gathered from the site investigations made by TVO and from the beginning of 1996, by Posiva. Since the site investigations are still ongoing and much of the data gathered still pending interpretation, only limited amount of new site-specific information has been available for the present assessment. (172 refs.).

  6. 76 FR 57981 - Environmental Management Site-Specific Advisory Board, Portsmouth

    Science.gov (United States)

    2011-09-19

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Portsmouth AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Portsmouth. The Federal Advisory Committee Act... environmental restoration, waste management and related activities. Tentative Agenda Call to Order...

  7. 77 FR 2283 - Environmental Management Site-Specific Advisory Board, Portsmouth

    Science.gov (United States)

    2012-01-17

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Portsmouth AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Portsmouth. The Federal Advisory Committee Act... environmental restoration, waste management and related activities. Tentative Agenda Call to Order...

  8. 76 FR 36100 - Environmental Management Site-Specific Advisory Board, Portsmouth

    Science.gov (United States)

    2011-06-21

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Portsmouth AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Portsmouth. The Federal Advisory Committee Act... environmental restoration, waste management and related activities. Tentative Agenda Call to Order...

  9. 77 FR 29997 - Environmental Management Site-Specific Advisory Board, Portsmouth

    Science.gov (United States)

    2012-05-21

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Portsmouth AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Portsmouth. The Federal Advisory Committee Act... environmental restoration, waste management and related activities. Tentative Agenda Call to Order...

  10. 77 FR 37390 - Environmental Management Site-Specific Advisory Board, Portsmouth

    Science.gov (United States)

    2012-06-21

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Portsmouth AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Portsmouth. The Federal Advisory Committee Act... environmental restoration, waste management and related activities. Tentative Agenda: Call to Order...

  11. 76 FR 78909 - Environmental Management Site-Specific Advisory Board, Portsmouth

    Science.gov (United States)

    2011-12-20

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Portsmouth AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Portsmouth. The Federal Advisory Committee Act... the areas of environmental restoration, waste management, and related activities. Tentative Agenda...

  12. 76 FR 50204 - Environmental Management Site-Specific Advisory Board, Nevada

    Science.gov (United States)

    2011-08-12

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Nevada AGENCY...-Wide Environmental Impact Statement (EIS) Committee of the Environmental Management Site- Specific... management in the areas of environmental restoration, waste management, and related activities. Purpose of...

  13. 77 FR 6790 - Environmental Management Site-Specific Advisory Board, Portsmouth

    Science.gov (United States)

    2012-02-09

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Portsmouth AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Portsmouth. The Federal Advisory Committee Act... environmental restoration, waste management and related activities. Tentative Agenda Call to Order...

  14. 75 FR 51026 - Environmental Management Site-Specific Advisory Board, Portsmouth

    Science.gov (United States)

    2010-08-18

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Portsmouth AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Portsmouth. The Federal Advisory Committee Act... the areas of environmental restoration, waste management and related activities. Tentative Agenda...

  15. Parametric investigation of working fluids for organic Rankine cycle applications

    International Nuclear Information System (INIS)

    Brown, J. Steven; Brignoli, Riccardo; Quine, Timothy

    2015-01-01

    This paper investigates working fluids for organic Rankine cycle (ORC) applications with a goal of identifying “ideal” working fluids for five renewable/alternative energy sources. It employs a methodology for screening and comparing with good engineering accuracy the thermodynamic performance potential of ORC operating with working fluids that are not well characterized experimentally or by high-accuracy equations of state. A wide range of “theoretical” working fluids are investigated with the goals to identify potential alternative working fluids and to guide future research and development efforts of working fluids. The “theoretical” working fluids investigated are described in terms of critical state properties, acentric factor, and ideal gas specific heat capacity at constant pressure and are obtained by parametrically varying each of these parameters. The performances of these “theoretical” working fluids are compared to the performances of several “real” working fluids. The study suggests a working fluid's critical temperature and its critical ideal gas molar heat capacity have the largest impact on the cycle efficiency and volumetric work output, with “ideal” working fluids for high efficiency possessing critical temperatures on the order of 100%–150% of the source temperature and possessing intermediate values of critical ideal gas molar heat capacity. - Highlights: • “Ideal” working fluids are investigated for organic Rankine cycles (ORC). • The thermodynamic space of “ideal” working fluids is parametrically investigated. • Five low- and high-temperature ORC applications are investigated. • 1620 “ideal” and several “real” working fluids per application are investigated.

  16. 75 FR 7577 - Environmental Management Site-Specific Advisory Board, Portsmouth

    Science.gov (United States)

    2010-02-22

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Portsmouth AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Portsmouth. The Federal Advisory Committee Act... areas of environmental restoration, waste management and related activities. Tentative Agenda: Call to...

  17. 75 FR 65615 - Environmental Management Site-Specific Advisory Board, Portsmouth

    Science.gov (United States)

    2010-10-26

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Portsmouth AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Portsmouth. The Federal Advisory Committee Act... areas of environmental restoration, waste management and related activities. Tentative Agenda Call to...

  18. 76 FR 17118 - Environmental Management Site-Specific Advisory Board Chairs

    Science.gov (United States)

    2011-03-28

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board Chairs AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB) Chairs. The Federal Advisory Committee Act (Pub... areas of environmental restoration, waste management, and related activities. Tentative Agenda Topics...

  19. 76 FR 62054 - Environmental Management Site-Specific Advisory Board Chairs

    Science.gov (United States)

    2011-10-06

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board Chairs AGENCY... of the Environmental Management Site-Specific Advisory Board (EM SSAB) Chairs. The Federal Advisory... environmental restoration, waste management, and related activities. Tentative Agenda Topics [cir] EM Program...

  20. 75 FR 82003 - Environmental Management Site-Specific Advisory Board, Portsmouth

    Science.gov (United States)

    2010-12-29

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Portsmouth AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Portsmouth. The Federal Advisory Committee Act... areas of environmental restoration, waste management and related activities. Tentative Agenda: Call to...

  1. 75 FR 19379 - Environmental Management Site-Specific Advisory Board, Portsmouth

    Science.gov (United States)

    2010-04-14

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Portsmouth AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Portsmouth. The Federal Advisory Committee Act... areas of environmental restoration, waste management and related activities. Tentative Agenda Call to...

  2. 77 FR 51789 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2012-08-27

    ... management and related activities. Tentative Agenda Call to Order, Introductions, Review of Agenda... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... Environmental Management Site-Specific Advisory Board (EM SSAB), Paducah. The Federal Advisory Committee Act...

  3. DOE's Environmental Management Site-Specific Advisory Board: The Roles, Work, and Assessment of the Constituent Local Boards - 13587

    International Nuclear Information System (INIS)

    Alexander, Catherine; Freeman, Jenny; Cantrell, Yvette

    2013-01-01

    The charter for the Department of Energy's Environmental Management (EM) Site-Specific Advisory Board (SSAB) was approved under the Federal Advisory Committee Act (FACA) in 1994. With a unique mandate to provide public input on issues associated with the cleanup of nuclear legacy sites in the U.S., the EM SSAB comprises eight local boards, which are based at major EM sites. While each board is unique to the community in which it is located and reflects the diversity of the local population, the boards are governed by FACA, related regulations, and DOE policies that are intended to standardize agency advisory board operations. The EM SSAB local boards are made up of a diverse group of citizens who want to understand the mission and goals of the EM program and to help EM achieve those goals for the benefit of their communities. Some are quite passionate about their mission; others need to be coaxed into active participation. Maintaining productive relationships and a supportive environment for effective board operations is the challenge of board management for DOE EM and the board members themselves. DOE draws on research findings and best practices literature from academics and practitioners in the field of public involvement in its board management practices. The EM SSAB is also evaluated annually under the law to ensure that the investment of taxpayer dollars in the board is warranted in light of the contributions of the board. Further evaluation takes place at the agency and site levels in order to identify what aspects of board functioning the agency and board members find important to its success and to address areas where improvement is needed. Board contributions, compliance factors, and measurable outcomes related to board products and process areas are key to agency commitment to ongoing support of the boards and to participant satisfaction and thus continued member involvement. In addition to evaluation of these factors in improving board effectiveness

  4. Work plan, health and safety plan, and site characterization for the Rust Spoil Area (D-106)

    International Nuclear Information System (INIS)

    Bohrman, D.E.; Uziel, M.S.; Landguth, D.C.; Hawthorne, S.W.

    1990-06-01

    As part of the Resource Conservation and Recovery Act (RCRA) Facility Investigation (RFI) of the Department of Energy's Y-12 Plant located in Oak Ridge, Tennessee, this work plan has been developed for the Rust Spoil Area (a solid waste disposal area). The work plan was developed by the Measurement Applications and Development Group (MAD) of the Health and Safety Research Division (HASRD) at Oak Ridge National Laboratory (ORNL) and will be implemented jointly by ORNL/MAD and the Y-12 Environmental Surveillance Section. This plan consists of four major sections: (1) a project description giving the scope and objectives of the investigation at the Rust Spoil Area; (2) field and sampling procedures describing sample documentation, soil sampling techniques, sample packaging and preservation, equipment decontamination, and disposal of investigation generated wastes; (3) sample analysis procedures detailing necessary analytical laboratory procedures to ensure the quality of chemical results from sample receipt through analysis and data reporting; and (4) a health and safety plan which describes general site hazards and particular hazards associated with specific tasks, assigns responsibilities, establishes personnel protection standards and mandatory safety procedures, and provides emergency information for contingencies that may arise during the course of field operations

  5. SNOSite: exploiting maximal dependence decomposition to identify cysteine S-nitrosylation with substrate site specificity.

    Directory of Open Access Journals (Sweden)

    Tzong-Yi Lee

    Full Text Available S-nitrosylation, the covalent attachment of a nitric oxide to (NO the sulfur atom of cysteine, is a selective and reversible protein post-translational modification (PTM that regulates protein activity, localization, and stability. Despite its implication in the regulation of protein functions and cell signaling, the substrate specificity of cysteine S-nitrosylation remains unknown. Based on a total of 586 experimentally identified S-nitrosylation sites from SNAP/L-cysteine-stimulated mouse endothelial cells, this work presents an informatics investigation on S-nitrosylation sites including structural factors such as the flanking amino acids composition, the accessible surface area (ASA and physicochemical properties, i.e. positive charge and side chain interaction parameter. Due to the difficulty to obtain the conserved motifs by conventional motif analysis, maximal dependence decomposition (MDD has been applied to obtain statistically significant conserved motifs. Support vector machine (SVM is applied to generate predictive model for each MDD-clustered motif. According to five-fold cross-validation, the MDD-clustered SVMs could achieve an accuracy of 0.902, and provides a promising performance in an independent test set. The effectiveness of the model was demonstrated on the correct identification of previously reported S-nitrosylation sites of Bos taurus dimethylarginine dimethylaminohydrolase 1 (DDAH1 and human hemoglobin subunit beta (HBB. Finally, the MDD-clustered model was adopted to construct an effective web-based tool, named SNOSite (http://csb.cse.yzu.edu.tw/SNOSite/, for identifying S-nitrosylation sites on the uncharacterized protein sequences.

  6. Prospects for site specific weed management

    DEFF Research Database (Denmark)

    Christensen, Svend; Rasmussen, Jesper; Pedersen, Søren Marcus

    2014-01-01

    Research on Site Specific Weed Management (SSWM) started in the late 80's. Since that moment, considerable research has been conducted on different aspects of SSWM, from fundamental studies on the spatial ecology of weeds to the applied development and testing of new technologies for weed detection...

  7. Site Observational Work Plan for the UMTRA project site at Ambrosia Lake, New Mexico

    International Nuclear Information System (INIS)

    1995-02-01

    Ground water compliance for the Uranium Mill Tailings Remedial Action (UMTRA) Project sites, including the Ambrosia Lake, New Mexico, site, is governed by the Uranium Mills Tailings Radiation Control Act (42 USC section 7901 et seq.) and the U.S. Environmental Protection Agency's Health and Environmental Protection Standards for Uranium and Thorium Mill Tailings (40 CFR Part 192; 60 FR 2854). The EPA standards describe specific conditions for which the U.S. Department of Energy (DOE) may apply for supplemental standards for contaminated ground water rather than meeting background levels or numerical standards. To achieve compliance with Subpart A of the EPA standards the residual radioactive materials are currently being consolidated on the site by the DOE in a disposal cell, isolating them from direct human or ecological contact and further dispersion into the environment. Completion of the disposal cell is scheduled for early 1995. An environmental assessment and a Finding of No Significant Impact (FONSI) were completed in 1987. Concurrence with the UMTRA Surface Project Ambrosia Lake remedial action plan (RAP) was granted by the U.S. Nuclear Regulatory Commission (NRC) and state of New Mexico in 1990. The DOE deferred compliance with Subpart B of the EPA standards in the Surface Project RAP. This site observational work plan (SOWP) is the first document to address ground water compliance under Subpart B at the Ambrosia Lake site. The Ambrosia Lake UMTRA Project site is within the Grants Mineral Belt and was one of numerous uranium mills supplied by many local mines. Ground water contamination at the site occurred as a result of uranium mill operations. Contamination of ground water resulted from discharge of waste water, infiltration of water through the tailings pile, hydraulic placement of mill tailings in nearby mines, and water pumped from mine shafts

  8. 77 FR 2282 - Environmental Management Site-Specific Advisory Board, Paducah

    Science.gov (United States)

    2012-01-17

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board, Paducah AGENCY... the Environmental Management Site-Specific Advisory Board, Paducah. This notice announces the... Management Officer. [FR Doc. 2012-831 Filed 1-12-12; 4:15 pm] BILLING CODE 6405-01-P ...

  9. Site-Specific Integration of Exogenous Genes Using Genome Editing Technologies in Zebrafish

    Directory of Open Access Journals (Sweden)

    Atsuo Kawahara

    2016-05-01

    Full Text Available The zebrafish (Danio rerio is an ideal vertebrate model to investigate the developmental molecular mechanism of organogenesis and regeneration. Recent innovation in genome editing technologies, such as zinc finger nucleases (ZFNs, transcription activator-like effector nucleases (TALENs and the clustered regularly interspaced short palindromic repeats (CRISPR/CRISPR associated protein 9 (Cas9 system, have allowed researchers to generate diverse genomic modifications in whole animals and in cultured cells. The CRISPR/Cas9 and TALEN techniques frequently induce DNA double-strand breaks (DSBs at the targeted gene, resulting in frameshift-mediated gene disruption. As a useful application of genome editing technology, several groups have recently reported efficient site-specific integration of exogenous genes into targeted genomic loci. In this review, we provide an overview of TALEN- and CRISPR/Cas9-mediated site-specific integration of exogenous genes in zebrafish.

  10. Effect of ionizing radiation on radionuclide speciation: Preliminary results from site-specific experiments in a basaltic system

    International Nuclear Information System (INIS)

    Reed, D.T.; Burnell, J.R.

    1986-01-01

    Rockwell Hanford Operations, under contract to the Department of Energy, is investigating the suitability of the Hanford site in the state of Washington as a high level nuclear waste repository. An important consideration in these investigations is the effect of ionizing radiation on the speciation of radionuclides in the groundwater after the high-level-waste container has been breached and there is direct contact between the groundwater and the waste form (controlled released period). The effect of ionizing radiation on radionuclide speciation depends on the radiation environment and site-specific chemistry near the waste container. With respect to these two aspects, the following results will be presented: a definition of the radiation environment during the controlled release period; preliminary site-specific experimental results: (1) basaltic systems spiked with radionuclides; (2) spent fuel-groundwater-basalt experiments

  11. Site-specific growth of Au particles on ZnO nanopyramids under ultraviolet illumination

    KAUST Repository

    Yao, Kexin

    2011-01-01

    In this work, wurtzite ZnO nanocrystals with unique "pyramid" morphology were firstly prepared via solvothermal synthesis. It was determined that the ZnO nanopyramids are grown along the polar c-axis with the vertexes pointing to the [001] direction. When the mixture of ZnO nanopyramids and Au precursor (HAuCl4) was exposed to ultraviolet (UV) illumination, Au particles were site-specifically formed on the vertexes of ZnO nanopyramids. The obtained Au/ZnO nanocomposite showed significantly enhanced photocatalytic activity as compared to the bare ZnO nanopyramids. First-principles based calculations well explained the formation of ZnO nanopyramids as well as the site-specific growth of Au, and revealed that during the photocatalysis process the Au particles can accommodate photoelectrons and thus facilitate the charge separation. © 2011 The Royal Society of Chemistry.

  12. Geochemical investigation of UMTRAP designated site at Salt Lake City, Utah

    International Nuclear Information System (INIS)

    Markos, G.; Bush, K.J.

    1983-09-01

    This report is the result of a geochemical investigation of the former uranium mill and tailings site at Salt Lake City, Utah. This is one in a series of site specific geochemical investigations performed on the inactive uranium mill tailings included in the Uranium Mill Tailings Remedial Action Project. The objectives of the investigation are to characterize the geochemistry, to determine the contaminant distribution resulting from the former milling activities and tailings, and to infer chemical pathways and transport mechanisms from the contaminant distribution. The results will be used to model contaminant migration and to develop criteria for long-term containment media such as a cover system which is impermeable to contaminant migration. This report assumes a familiarity with the hydrologic conditions of the site and the geochemical concepts underlying the investigation. The results reported are based on a one-time sampling of waters and solid material from the background, the area adjacent to the site, and the site. The solid samples were water extracted to remove easily soluble salts and acid extracted to remove carbonates and hydroxides. The water extracts and solid samples were anlyzed for the major and trace elements. The report includes the methods of sampling, sample processing, analysis, and data interpretation. Four major conclusions are: (1) sediments in the ditches and creeks adjacent to the site contain tailings, however, the waters were generally not contaminated; (2) tailings are mixed with the soils within a meter below the tailings in some locations, however, water-soluble contaminants decrease to below background levels within 30 cm below the tailings; (3) there has not been significant acid seepage into the soils below the tailings; and (4) salt crusts on the tailings contain trace elements, with the elements that form chloride complexes having the greatest accumulation

  13. A Hypothesis-Driven Approach to Site Investigation

    Science.gov (United States)

    Nowak, W.

    2008-12-01

    Variability of subsurface formations and the scarcity of data lead to the notion of aquifer parameters as geostatistical random variables. Given an information need and limited resources for field campaigns, site investigation is often put into the context of optimal design. In optimal design, the types, numbers and positions of samples are optimized under case-specific objectives to meet the information needs. Past studies feature optimal data worth (balancing maximum financial profit in an engineering task versus the cost of additional sampling), or aim at a minimum prediction uncertainty of stochastic models for a prescribed investigation budget. Recent studies also account for other sources of uncertainty outside the hydrogeological range, such as uncertain toxicity, ingestion and behavioral parameters of the affected population when predicting the human health risk from groundwater contaminations. The current study looks at optimal site investigation from a new angle. Answering a yes/no question under uncertainty directly requires recasting the original question as a hypothesis test. Otherwise, false confidence in the resulting answer would be pretended. A straightforward example is whether a recent contaminant spill will cause contaminant concentrations in excess of a legal limit at a nearby drinking water well. This question can only be answered down to a specified chance of error, i.e., based on the significance level used in hypothesis tests. Optimal design is placed into the hypothesis-driven context by using the chance of providing a false yes/no answer as new criterion to be minimized. Different configurations apply for one-sided and two-sided hypothesis tests. If a false answer entails financial liability, the hypothesis-driven context can be re-cast in the context of data worth. The remaining difference is that failure is a hard constraint in the data worth context versus a monetary punishment term in the hypothesis-driven context. The basic principle

  14. Proposed Site-Specific Response Spectra for Surabaya-Madura Bridge

    Directory of Open Access Journals (Sweden)

    Dyah Kusumastuti

    2008-01-01

    Full Text Available This paper presents a site-specific seismic hazard study to determine the recommended seismic design criteria for Suramadu Bridge. The study is performed using probabilistic seismic hazard approach to determine maximum acceleration and response spectra at bedrock and followed by local site effect analysis to determine maximum acceleration and response spectra at ground surface. The probabilistic seismic hazard analysis (PSHA is carried out using 3-dimension (3-D seismic source models (fault source model. Two hazard levels are analysed to represent 150 and 3,300 years return period of ground motion around site location. The local site effect analysis is performed using 1-dimension (1-D shear wave propagation theory to obtain peak ground acceleration and response spectra at ground surface. Finally, the site-specific surface response spectra with 5 percent damping are developed based on the mean plus one standard deviation concept from the result of local site effect analysis.

  15. Site investigations and conceptual design for the repository in the nuclear 'Entsorgungszentrum' of the Federal Republic of Germany

    International Nuclear Information System (INIS)

    Roethemeyer, H.

    1980-01-01

    Site investigations are planned to enable the Physikalisch-Technische Bundesanstalt and the other institutions involved to scrutinize the suitability of the Gorleben site and its salt dome as the nuclear 'Entsorgungszentrum' repository, and to provide all data necessary for detailed site-specific planning and safe building and operation of the repository. The investigations include deep drillings and an extensive hydrogeological programme for exploring the general structure of the salt dome and its environment. The latter programme started on 17 April 1979. The Bundesanstalt fuer Geowissenschaften und Rohstoffe (Federal Geological Survey) is in charge of the geoscientific side of the investigations. For the site-independent conceptual design the following requirements have been laid down: (1) for safety reasons retrievability is not to be considered; (2) standard mining techniques and the special experience gained at the Asse salt mine should be utilized as much as possible; (3) two shafts should be sufficient for the mine, for all transport and the ventilation system; (4) different forms of waste in terms of waste type and container shall be disposed of in different storage areas; (5) ventilated sections must permit the shutting off of each storage area from the rest of the mine; (6) the mining method of retreat working should be applied in order to explore the whole disposal area prior to the beginning of disposal, to enable an optimal fit of the mine to the structure of the salt dome, and to move away from the heat generated by heat-producing waste; (7) the mine works shall have a lateral safety distance to the cap rock of 200 m and a vertical safety zone of 300 m beneath the salt level. (8) all disposal areas shall be on one level; (9) salt and waste shall be transported in different drifts, mainly in a one-way system. (author)

  16. Geotechnical investigations of the PEP site

    International Nuclear Information System (INIS)

    Gould, R.S.

    1976-02-01

    The purpose of this paper is to summarize the general nature of the geology and rock and soil formations of the PEP site as they relate to the design and construction of the project; to describe site investigation programs and to catalog the geotechnical information presently available about the site. The recently-completed investigation of subterranean conditions around the PEP ring when coupled with previous surveys gives us a good understanding of what to expect with regard to tunneling, undertaking larger underground excavations and constructing research halls are the interaction areas. It bears out the predictions made in Jacobs and Associates' report of 1973; i.e., that the ring housing construction is classified as soft-ground tunneling and that large underground openings, such as region 10 and the injection junction structures, will require great attention to support. A shield or shields will probably be required. On the positive side, the site affords very good conditions for soft-ground tunneling. Water will be a problem in some areas, but not an unsolvable one. The possibility of encountering lethal or explosive gases, almost always the case in tunneling in California's coastal formations, exists but has not been ascertained. Finally, no reasons to change current cost estimates or schedules have merged from the investigation. 13 refs., 1 fig

  17. Site investigation SFR. Hydrogeological modelling of SFR. Model version 0.2

    Energy Technology Data Exchange (ETDEWEB)

    Oehman, Johan (Golder Associates AB (Sweden)); Follin, Sven (SF GeoLogic (Sweden))

    2010-01-15

    The Swedish Nuclear Fuel and Waste Management Company (SKB) has conducted site investigations for a planned extension of the existing final repository for short-lived radioactive waste (SFR). A hydrogeological model is developed in three model versions, which will be used for safety assessment and design analyses. This report presents a data analysis of the currently available hydrogeological data from the ongoing Site Investigation SFR (KFR27, KFR101, KFR102A, KFR102B, KFR103, KFR104, and KFR105). The purpose of this work is to develop a preliminary hydrogeological Discrete Fracture Network model (hydro-DFN) parameterisation that can be applied in regional-scale modelling. During this work, the Geologic model had not yet been updated for the new data set. Therefore, all analyses were made to the rock mass outside Possible Deformation Zones, according to Single Hole Interpretation. Owing to this circumstance, it was decided not to perform a complete hydro-DFN calibration at this stage. Instead focus was re-directed to preparatory test cases and conceptual questions with the aim to provide a sound strategy for developing the hydrogeological model SFR v. 1.0. The presented preliminary hydro-DFN consists of five fracture sets and three depth domains. A statistical/geometrical approach (connectivity analysis /Follin et al. 2005/) was performed to estimate the size (i.e. fracture radius) distribution of fractures that are interpreted as Open in geologic mapping of core data. Transmissivity relations were established based on an assumption of a correlation between the size and evaluated specific capacity of geologic features coupled to inflows measured by the Posiva Flow Log device (PFL-f data). The preliminary hydro-DFN was applied in flow simulations in order to test its performance and to explore the role of PFL-f data. Several insights were gained and a few model technical issues were raised. These are summarised in Table 5-1

  18. Site investigation SFR. Hydrogeological modelling of SFR. Model version 0.2

    International Nuclear Information System (INIS)

    Oehman, Johan; Follin, Sven

    2010-01-01

    The Swedish Nuclear Fuel and Waste Management Company (SKB) has conducted site investigations for a planned extension of the existing final repository for short-lived radioactive waste (SFR). A hydrogeological model is developed in three model versions, which will be used for safety assessment and design analyses. This report presents a data analysis of the currently available hydrogeological data from the ongoing Site Investigation SFR (KFR27, KFR101, KFR102A, KFR102B, KFR103, KFR104, and KFR105). The purpose of this work is to develop a preliminary hydrogeological Discrete Fracture Network model (hydro-DFN) parameterisation that can be applied in regional-scale modelling. During this work, the Geologic model had not yet been updated for the new data set. Therefore, all analyses were made to the rock mass outside Possible Deformation Zones, according to Single Hole Interpretation. Owing to this circumstance, it was decided not to perform a complete hydro-DFN calibration at this stage. Instead focus was re-directed to preparatory test cases and conceptual questions with the aim to provide a sound strategy for developing the hydrogeological model SFR v. 1.0. The presented preliminary hydro-DFN consists of five fracture sets and three depth domains. A statistical/geometrical approach (connectivity analysis /Follin et al. 2005/) was performed to estimate the size (i.e. fracture radius) distribution of fractures that are interpreted as Open in geologic mapping of core data. Transmissivity relations were established based on an assumption of a correlation between the size and evaluated specific capacity of geologic features coupled to inflows measured by the Posiva Flow Log device (PFL-f data). The preliminary hydro-DFN was applied in flow simulations in order to test its performance and to explore the role of PFL-f data. Several insights were gained and a few model technical issues were raised. These are summarised in Table 5-1

  19. 76 FR 20651 - Environmental Management Site-Specific Advisory Board Chairs

    Science.gov (United States)

    2011-04-13

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board Chairs AGENCY... a meeting on April 13-14, 2011 of the Environmental Management Site-Specific Advisory Board Chairs... R. Butler, Acting Deputy Committee Management Officer. [FR Doc. 2011-8970 Filed 4-8-11; 4:15 pm...

  20. FLP recombinase-mediated site-specific recombination in silkworm, Bombyx mori

    Science.gov (United States)

    A comprehensive understanding of gene function and the production of site-specific genetically modified mutants are two major goals of genetic engineering in the post-genomic era. Although site-specific recombination systems have been powerful tools for genome manipulation of many organisms, they h...

  1. Evaluating Variability and Uncertainty of Geological Strength Index at a Specific Site

    Science.gov (United States)

    Wang, Yu; Aladejare, Adeyemi Emman

    2016-09-01

    Geological Strength Index (GSI) is an important parameter for estimating rock mass properties. GSI can be estimated from quantitative GSI chart, as an alternative to the direct observational method which requires vast geological experience of rock. GSI chart was developed from past observations and engineering experience, with either empiricism or some theoretical simplifications. The GSI chart thereby contains model uncertainty which arises from its development. The presence of such model uncertainty affects the GSI estimated from GSI chart at a specific site; it is, therefore, imperative to quantify and incorporate the model uncertainty during GSI estimation from the GSI chart. A major challenge for quantifying the GSI chart model uncertainty is a lack of the original datasets that have been used to develop the GSI chart, since the GSI chart was developed from past experience without referring to specific datasets. This paper intends to tackle this problem by developing a Bayesian approach for quantifying the model uncertainty in GSI chart when using it to estimate GSI at a specific site. The model uncertainty in the GSI chart and the inherent spatial variability in GSI are modeled explicitly in the Bayesian approach. The Bayesian approach generates equivalent samples of GSI from the integrated knowledge of GSI chart, prior knowledge and observation data available from site investigation. Equations are derived for the Bayesian approach, and the proposed approach is illustrated using data from a drill and blast tunnel project. The proposed approach effectively tackles the problem of how to quantify the model uncertainty that arises from using GSI chart for characterization of site-specific GSI in a transparent manner.

  2. Precision agriculture - from mapping to site-specific application

    DEFF Research Database (Denmark)

    Pedersen, Søren Marcus; Lind, Kim Martin Hjorth

    2017-01-01

    of each chapter in the book. Each chapter address a different topic starting with an overview of technologies that are currently available, followed by specific Variable-Rate Technologies such as VRT fertilizer application, VRT pesticide application, site-specific irrigation management, Auto...

  3. An Intraoperative Site-specific Bone Density Device: A Pilot Test Case.

    Science.gov (United States)

    Arosio, Paolo; Moschioni, Monica; Banfi, Luca Maria; Di Stefano, Anilo Alessio

    2015-08-01

    This paper reports a case of all-on-four rehabilitation where bone density at implant sites was assessed both through preoperative computed tomographic (CT) scans and using a micromotor working as an intraoperative bone density measurement device. Implant-supported rehabilitation is a predictable treatment option for tooth replacement whose success depends on the clinician's experience, the implant characteristics and location and patient-related factors. Among the latter, bone density is a determinant for the achievement of primary implant stability and, eventually, for implant success. The ability to measure bone density at the placement site before implant insertion could be important in the clinical setting. A patient complaining of masticatory impairment was presented with a plan calling for extraction of all her compromised teeth, followed by implant rehabilitation. A week before surgery, she underwent CT examination, and the bone density on the CT scans was measured. When the implant osteotomies were created, the bone density was again measured with a micromotor endowed with an instantaneous torque-measuring system. The implant placement protocols were adapted for each implant, according to the intraoperative measurements, and the patient was rehabilitated following an all-on-four immediate loading protocol. The bone density device provided valuable information beyond that obtained from CT scans, allowing for site-specific, intraoperative assessment of bone density immediately before implant placement and an estimation of primary stability just after implant insertion. Measuring jaw-bone density could help clinicians to select implant-placement protocols and loading strategies based on site-specific bone features.

  4. Expedited site characterization. Innovative technology summary report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-12-01

    Expedited Site Characterization (ESC) has been developed, demonstrated, and deployed as a new time-saving, cost-effective approach for hazardous waste site investigations. ESC is an alternative approach that effectively shortens the length of the assessment period and may significantly reduce costs at many sites. It is not a specific technology or system but is a methodology for most effectively conducting a site characterization. The principal elements of ESC are: a field investigation conducted by an integrated team of experienced professionals working in the field at the same time, analysis, integration and initial validation of the characterization data as they are obtained in the field, and a dynamic work plan that enables the team to take advantage of new insights from recent data to adjust the work plan in the field. This report covers demonstrations that took place between 1989 and 1996. This paper gives a description of the technology and discusses its performance, applications, cost, regulatory and policy issues, and lessons learned.

  5. Expedited site characterization. Innovative technology summary report

    International Nuclear Information System (INIS)

    1998-12-01

    Expedited Site Characterization (ESC) has been developed, demonstrated, and deployed as a new time-saving, cost-effective approach for hazardous waste site investigations. ESC is an alternative approach that effectively shortens the length of the assessment period and may significantly reduce costs at many sites. It is not a specific technology or system but is a methodology for most effectively conducting a site characterization. The principal elements of ESC are: a field investigation conducted by an integrated team of experienced professionals working in the field at the same time, analysis, integration and initial validation of the characterization data as they are obtained in the field, and a dynamic work plan that enables the team to take advantage of new insights from recent data to adjust the work plan in the field. This report covers demonstrations that took place between 1989 and 1996. This paper gives a description of the technology and discusses its performance, applications, cost, regulatory and policy issues, and lessons learned

  6. Aespoe HRL - Geoscientific evaluation 1997/2. Results from pre-investigation and detailed site characterization. Summary report

    International Nuclear Information System (INIS)

    Rhen, I.; Baeckbom, G.; Stanfors, R.; Wikberg, P.

    1997-05-01

    The work at Aespoe Hard rock laboratory provides an important scientific and technical basis for implementing and operating a future deep repository in Sweden. A milestone has now been reached with the completion of the pre investigation and construction phases at Aespoe HRL. The present data base at Aespoe HRL is one of the most comprehensive data bases in the world for crystalline rock properties, containing data from a large number of investigation methods from the surface down to 1700 m below ground level. Site characterization in conjunction with construction work has basically confirmed the pre-construction models. The site characterization has been a realistic 'dress rehearsal' that is invaluable for planning and execution of surface and underground characterization of sites for the deep repository for spent nuclear fuel in Sweden

  7. Plutonium-related work and cause-specific mortality at the United States Department of Energy Hanford Site.

    Science.gov (United States)

    Wing, Steve; Richardson, David; Wolf, Susanne; Mihlan, Gary

    2004-02-01

    Health effects of working with plutonium remain unclear. Plutonium workers at the United States Department of Energy (US-DOE) Hanford Site in Washington State, USA were evaluated for increased risks of cancer and non-cancer mortality. Periods of employment in jobs with routine or non-routine potential for plutonium exposure were identified for 26,389 workers hired between 1944 and 1978. Life table regression was used to examine associations of length of employment in plutonium jobs with confirmed plutonium deposition and with cause specific mortality through 1994. Incidence of confirmed internal plutonium deposition in all plutonium workers was 15.4 times greater than in other Hanford jobs. Plutonium workers had low death rates compared to other workers, particularly for cancer causes. Mortality for several causes was positively associated with length of employment in routine plutonium jobs, especially for employment at older ages. At ages 50 and above, death rates for non-external causes of death, all cancers, cancers of tissues where plutonium deposits, and lung cancer, increased 2.0 +/- 1.1%, 2.6 +/- 2.0%, 4.9 +/- 3.3%, and 7.1 +/- 3.4% (+/-SE) per year of employment in routine plutonium jobs, respectively. Workers employed in jobs with routine potential for plutonium exposure have low mortality rates compared to other Hanford workers even with adjustment for demographic, socioeconomic, and employment factors. This may be due, in part, to medical screening. Associations between duration of employment in jobs with routine potential for plutonium exposure and mortality may indicate occupational exposure effects. Copyright 2004 Wiley-Liss, Inc.

  8. An Investigation Into the Navy Public Works Centers Specific Work Service Processing Problems.

    Science.gov (United States)

    1980-12-01

    complex interface of all the elements of individual and organizational behavior. These elements include leadership , motivation, productivity, group...site; variances: nzineering; d. iob control: (ield leadership ; emploYee attitudes; accurac’: or estimates e. and 4ob olans "no problems". 31. Are...indica-ed prcvidinz -he hesr re3s. e I.nck -a- situation or thoughts. The "you" in -.- Il -r your organizatinal element in genera-, .-nis Jn multipie

  9. Site Observational Work Plan for the UMTRA Project Site at Shiprock, New Mexico. Revision

    International Nuclear Information System (INIS)

    1995-07-01

    The site observational work plan (SOWP) for the Shiprock, New Mexico, Uranium Mill Tailings Remedial Action (UMTRA) Project Site is one of the first documents for developing an approach for achieving ground water compliance at the site. This SOWP applies Shiprock site information to a regulatory compliance framework, which identifies strategies for meeting ground water compliance at the site. The compliance framework was developed in the UMTRA ground water programmatic environmental impact statement

  10. Green Remediation Best Management Practices: Site Investigation

    Science.gov (United States)

    The U.S. EPA Principles for Greener Cleanups outline the Agency's policy for evaluating and minimizing the environmental 'footprint' of activities undertaken when cleaning up a contaminated site and conducting site investigation.

  11. Deconstructing thermodynamic parameters of a coupled system from site-specific observables.

    Science.gov (United States)

    Chowdhury, Sandipan; Chanda, Baron

    2010-11-02

    Cooperative interactions mediate information transfer between structural domains of a protein molecule and are major determinants of protein function and modulation. The prevalent theories to understand the thermodynamic origins of cooperativity have been developed to reproduce the complex behavior of a global thermodynamic observable such as ligand binding or enzyme activity. However, in most cases the measurement of a single global observable cannot uniquely define all the terms that fully describe the energetics of the system. Here we establish a theoretical groundwork for analyzing protein thermodynamics using site-specific information. Our treatment involves extracting a site-specific parameter (defined as χ value) associated with a structural unit. We demonstrate that, under limiting conditions, the χ value is related to the direct interaction terms associated with the structural unit under observation and its intrinsic activation energy. We also introduce a site-specific interaction energy term (χ(diff)) that is a function of the direct interaction energy of that site with every other site in the system. When combined with site-directed mutagenesis and other molecular level perturbations, analyses of χ values of site-specific observables may provide valuable insights into protein thermodynamics and structure.

  12. Remedial Investigation Work Plan for Upper East Fork Poplar Creek Operable Unit 3 at the Oak Ridge Y-12 Plant, Oak Ridge, Tennessee. Environmental Restoration Program

    Energy Technology Data Exchange (ETDEWEB)

    1993-08-01

    Upper East Fork Popular Creek Operable Unit 3 (UEFPC OU 3) is a source term OU composed of seven sites, and is located in the western portion of the Y-12 Plant. For the most part, the UEFPC OU 3 sites served unrelated purposes and are geographically removed from one another. The seven sites include the following: Building 81-10, the S-2 Site, Salvage Yard oil storage tanks, the Salvage Yard oil/solvent drum storage area, Tank Site 2063-U, the Salvage Yard drum deheader, and the Salvage Yard scrap metal storage area. All of these sites are contaminated with at least one or more hazardous and/or radioactive chemicals. All sites have had some previous investigation under the Y-12 Plant RCRA Program. The work plan contains summaries of geographical, historical, operational, geological, and hydrological information specific to each OU 3 site. The potential for release of contaminants to receptors through various media is addressed, and a sampling and analysis plan is presented to obtain objectives for the remedial investigation. Proposed sampling activities are contingent upon the screening level risk assessment, which includes shallow soil sampling, soil borings, monitoring well installation, groundwater sampling, and surface water sampling. Data from the site characterization activities will be used to meet the above objectives. A Field Sampling Investigation Plan, Health and Safety Plan, and Waste Management Plan are also included in this work plan.

  13. 76 FR 5365 - Environmental Management Site-Specific Advisory Board, Nevada

    Science.gov (United States)

    2011-01-31

    ... Industrial Sites and Soils Committees of the Environmental Management Site-Specific Advisory Board (EM SSAB... sites at the Nevada National Security Site including decontamination, closure, re-use and/or demolition. Purpose of the Soils Committee: The purpose of the Committee is to focus on issues related to soil...

  14. 75 FR 71677 - Environmental Management Site-Specific Advisory Board, Nevada

    Science.gov (United States)

    2010-11-24

    ... Industrial Sites and Soils Committees of the Environmental Management Site-Specific Advisory Board (EM SSAB... sites at the Nevada Test Site including decontamination, closure, re-use and/or demolition. Purpose of the Soils Committee: The purpose of the Committee is to focus on issues related to soil contamination...

  15. On-site management of investigational products and drug delivery systems in conformity with Good Clinical Practices (GCPs).

    Science.gov (United States)

    Méthot, Julie; Brisson, Diane; Gaudet, Daniel

    2012-04-01

    Investigators and research teams participating in clinical trials have to deal with complex investigational products, study designs, and research environments. The emergence of new drug delivery systems and investigational products combining more than one drug and the development of biodrugs such as monoclonal antibodies, peptides, siRNA, and gene therapy to treat orphan or common diseases constitute a new challenge for investigators and clinical sites. We describe the requirements and challenges of drug management in conformity with Good Clinical Practices (GCPs) for investigators and sites participating in clinical trials. Review At all sites participating in clinical trials, standard operating procedures (SOPs) covering the critical path of drug and drug delivery systems management are required. All steps should be auditable, including reception, validation, storage, access, preparation, distribution, techniques of administration, use, return, and destruction of research products. Biodrugs require traceability and specific SOPs on the management of potential immune reactions. Investigational products must be stored under standard auditable conditions. The traceability of storage conditions (including temperature) requires these conditions to be monitored on a continuous basis. A dedicated space with restricted access limited to authorized qualified personnel facilitates the monitoring. The development of standardized, auditable settings and the application of dedicated, site-specific SOPs for the management of investigational products and drug delivery systems contribute to guarantee the compliance to GCP requirements.

  16. Site-specifically {sup 89}Zr-labeled monoclonal antibodies for ImmunoPET

    Energy Technology Data Exchange (ETDEWEB)

    Tinianow, Jeff N.; Gill, Herman S.; Ogasawara, Annie; Flores, Judith E.; Vanderbilt, Alexander N.; Luis, Elizabeth; Vandlen, Richard; Darwish, Martine; Junutula, Jagath R.; Williams, Simon-P. [Genentech Research and Early Development, Genentech Inc., South San Francisco, CA 94080 (United States); Marik, Jan [Genentech Research and Early Development, Genentech Inc., South San Francisco, CA 94080 (United States)], E-mail: marik.jan@gene.com

    2010-04-15

    Three thiol reactive reagents were developed for the chemoselective conjugation of desferrioxamine (Df) to a monoclonal antibody via engineered cysteine residues (thio-trastuzumab). The in vitro stability and in vivo imaging properties of site-specifically radiolabeled {sup 89}Zr-Df-thio-trastuzumab conjugates were investigated. Methods: The amino group of desferrioxamine B was acylated by bromoacetyl bromide, N-hydroxysuccinimidyl iodoacetate, or N-hydroxysuccinimidyl 4-[N-maleimidomethyl]cyclohexane-1-carboxylate to obtain thiol reactive reagents bromoacetyl-desferrioxamine (Df-Bac), iodoacetyl-desferrioxamine (Df-Iac) and maleimidocyclohexyl-desferrioxamine (Df-Chx-Mal), respectively. Df-Bac and Df-Iac alkylated the free thiol groups of thio-trastuzumab by nucleophilic substitution forming Df-Ac-thio-trastuzumab, while the maleimide reagent Df-Chx-Mal reacted via Michael addition to provide Df-Chx-Mal-thio-trastuzumab. The conjugates were radiolabeled with {sup 89}Zr and evaluated for serum stability, and their positron emission tomography (PET) imaging properties were investigated in a BT474M1 (HER2-positive) breast tumor mouse model. Results: The chemoselective reagents were obtained in 14% (Df-Bac), 53% (Df-Iac) and 45% (Df-Chx-Mal) yields. Site-specific conjugation of Df-Chx-Mal to thio-trastuzumab was complete within 1 h at pH 7.5, while Df-Iac and Df-Bac respectively required 2 and 5 h at pH 9. Each Df modified thio-trastuzumab was chelated with {sup 89}Zr in yields exceeding 75%. {sup 89}Zr-Df-Ac-thio-trastuzumab and {sup 89}Zr-Df-Chx-Mal-thio-trastuzumab were stable in mouse serum and exhibited comparable PET imaging capabilities in a BT474M1 (HER2-positive) breast cancer model reaching 20-25 %ID/g of tumor uptake and a tumor to blood ratio of 6.1-7.1. Conclusions: The new reagents demonstrated good reactivity with engineered thiol groups of trastuzumab and very good chelation properties with {sup 89}Zr. The site-specifically {sup 89}Zr-labeled thio

  17. Adaptation of the ITER facility design to a Canadian site

    International Nuclear Information System (INIS)

    Smith, S.

    2001-01-01

    This paper presents the status of Canadian efforts to adapt the newly revised ITER facility design to suit the specific characteristics of the proposed Canadian site located in Clarington, west of Toronto, Ontario. ITER Canada formed a site-specific design team in 1999, comprising participants from three Canadian consulting companies to undertake this work. The technical aspects of this design activity includes: construction planning, geotechnical investigations, plant layout, heat sink design, electrical system interface, site-specific modifications and tie-ins, seismic design, and radwaste management. These areas are each addressed in this paper. (author)

  18. Stimulus-specific variability in color working memory with delayed estimation.

    Science.gov (United States)

    Bae, Gi-Yeul; Olkkonen, Maria; Allred, Sarah R; Wilson, Colin; Flombaum, Jonathan I

    2014-04-08

    Working memory for color has been the central focus in an ongoing debate concerning the structure and limits of visual working memory. Within this area, the delayed estimation task has played a key role. An implicit assumption in color working memory research generally, and delayed estimation in particular, is that the fidelity of memory does not depend on color value (and, relatedly, that experimental colors have been sampled homogeneously with respect to discriminability). This assumption is reflected in the common practice of collapsing across trials with different target colors when estimating memory precision and other model parameters. Here we investigated whether or not this assumption is secure. To do so, we conducted delayed estimation experiments following standard practice with a memory load of one. We discovered that different target colors evoked response distributions that differed widely in dispersion and that these stimulus-specific response properties were correlated across observers. Subsequent experiments demonstrated that stimulus-specific responses persist under higher memory loads and that at least part of the specificity arises in perception and is eventually propagated to working memory. Posthoc stimulus measurement revealed that rendered stimuli differed from nominal stimuli in both chromaticity and luminance. We discuss the implications of these deviations for both our results and those from other working memory studies.

  19. Work plan for the remedial investigation/feasibility study-environmental assessment for the quarry residuals operable unit at the Weldon Spring Site

    Energy Technology Data Exchange (ETDEWEB)

    1994-01-01

    The US Department of Energy (DOE) is conducting cleanup activities at the Weldon Spring site, which is located in St. Charles County, Missouri, about 48 km (30 mi) west of St. Louis. The Weldon Spring site consists of two noncontiguous areas -- the chemical plant area, which includes four raffinate pits, and the quarry. Cleanup activities at the Weldon Spring site are conducted in accordance with the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), as amended, incorporating the values of the National Environmental Policy Act (NEPA). The contents of the documents prepared for the project are not intended to represent a statement regarding the legal applicability of NEPA to remedial actions conducted under CERCLA. In accordance with the integrated CERCLA/NEPA approach, a remedial investigation/feasibility study-environmental assessment (RI/FS-EA) is being conducted to evaluate conditions and potential responses for the quarry residuals operable unit (QROU). This operable unit consists of the following areas and/or media: the residual material remaining at the Weldon Spring quarry after removal of the pond water and bulk waste; underlying groundwater; and other media located in the surrounding vicinity of the quarry, including adjacent soil, surface water, and sediment in Femme Osage Slough. This work plan identifies the activities within the RI/FS-EA process that are being proposed to address contamination remaining at the quarry area.

  20. Work plan for the remedial investigation/feasibility study-environmental assessment for the quarry residuals operable unit at the Weldon Spring Site

    International Nuclear Information System (INIS)

    1994-01-01

    The US Department of Energy (DOE) is conducting cleanup activities at the Weldon Spring site, which is located in St. Charles County, Missouri, about 48 km (30 mi) west of St. Louis. The Weldon Spring site consists of two noncontiguous areas -- the chemical plant area, which includes four raffinate pits, and the quarry. Cleanup activities at the Weldon Spring site are conducted in accordance with the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), as amended, incorporating the values of the National Environmental Policy Act (NEPA). The contents of the documents prepared for the project are not intended to represent a statement regarding the legal applicability of NEPA to remedial actions conducted under CERCLA. In accordance with the integrated CERCLA/NEPA approach, a remedial investigation/feasibility study-environmental assessment (RI/FS-EA) is being conducted to evaluate conditions and potential responses for the quarry residuals operable unit (QROU). This operable unit consists of the following areas and/or media: the residual material remaining at the Weldon Spring quarry after removal of the pond water and bulk waste; underlying groundwater; and other media located in the surrounding vicinity of the quarry, including adjacent soil, surface water, and sediment in Femme Osage Slough. This work plan identifies the activities within the RI/FS-EA process that are being proposed to address contamination remaining at the quarry area

  1. Establishment of monoclonal HCC cell lines with organ site-specific tropisms

    International Nuclear Information System (INIS)

    Wan, Jinliang; Wen, Duo; Dong, Lili; Tang, Jun; Liu, Dongli; Liu, Yang; Tao, Zhonghua; Gao, Dongmei; Sun, Huichuan; Cao, Ya; Fan, Jia; Wu, Weizhong

    2015-01-01

    Organ site-specific metastasis is an ominous feature for most poor-prognostic hepatocellular carcinoma (HCC) patients. Cancer cell lines and animal models are indispensable for investigating the molecular mechanisms of organ specific tropism. However, till now, little is known about the drivers in HCC metastatic tropism, and also no effective way has been developed to block the process of tropistic metastasis. In this study, we established several monoclonal HCC cell lines from HCCLM3-RFP together with their xenograft models, and then analyzed their metastatic potentials and tropisms using in-vitro and in-vivo assays, and finally elucidated the driving forces of HCC tropistic metastases. Six monoclonal cell lines with different organ site-specific tropism were established successfully. SPARC, VCAM1 and ANGPTL4 were found positively correlated with the potentials of lung metastasis, while ITGA1 had a positive relation to lymph node metastasis of enterocoelia. By our powerful platforms, HCC metastatic tropisms in clinic could be easily mimicked and recapitulated for exploring the bilateral interactions between tumor and its microenvironment, elucidating the drivers of HCC metastatic tropisms, and testing anti-cancer effects of newly developed agent in pre-clinical stage. The online version of this article (doi:10.1186/s12885-015-1692-0) contains supplementary material, which is available to authorized users

  2. Remedial Investigation Work Plan for J-Field, Aberdeen Proving Ground, Maryland

    Energy Technology Data Exchange (ETDEWEB)

    Benioff, P.; Biang, R.; Dolak, D.; Dunn, C.; Haffenden, R.; Martino, L.; Patton, T.; Wang, Y.; Yuen, C.

    1995-03-01

    The purpose of an RI/FS is to characterize the nature and extent of the risks posed by contaminants present at a site and to develop and evaluate options for remedial actions. The overall objective of the RI is to provide a comprehensive evaluation of site conditions, types and quantities of contaminants present, release mechanisms and migration pathways, target populations, and risks to human health and the environment. The information developed during the RI provides the basis for the design and implementation of remedial actions during the FS. The purpose of this RI Work Plan is to define the tasks that will direct the remedial investigation of the J-Field site at APG.

  3. Integrated account of method, site selection and programme prior to the site investigation phase

    International Nuclear Information System (INIS)

    2000-12-01

    In order to dispose of the spent nuclear fuel in a safe manner, SKB plans to site a deep repository and an encapsulation plant with associated canister fabrication and transportation system. After an integrated evaluation of feasibility studies and other material, SKB will proceed with investigations of the rock and studies regarding establishment of the deep disposal system in the municipality of Oskarshamn or in Northern Uppland. The plans also include further study of the prospects for a deep repository in the municipality of Nykoeping. In the municipality of Oskarshamn, SKB plans further studies of a siting of the deep repository at Simpevarp. There SKB wants to initiate site investigations with test drilling. For the encapsulation plant, SKB wants to continue studying a siting at CLAB. In Northern Uppland, SKB plans to study two siting alternatives for the deep repository. One is Forsmark in the municipality of Oesthammar, where SKB wants to initiate a site investigation with test drilling. The other is Tierp north of Skutskaer, where SKB intends to start test drilling in an area north of Tierp. First, however, a suitable drilling area with possible transport solutions needs to be defined. This alternative requires the participation of the municipalities of both Tierp and Aelvkarleby. A siting of the encapsulation plant in Northern Uppland will also be studied. For the municipality of Nykoeping, SKB plans to conduct a new safety assessment for the Fjaellveden area, based on data from previous investigations as well as additional studies of how a deep repository could be arranged. SKB will thereby gather data from yet another geographic and geological region beyond those that are prioritized. No test drilling is planned in Nykoeping. The goal of the site investigation phase is to obtain all permits needed to build the planned facilities. It will take an estimated 7 - 8 years to assemble the requisite supporting material, carry out consultations, compile siting

  4. Aespoe HRL - Geoscientific evaluation 1997/2. Results from pre-investigation and detailed site characterization. Summary report

    Energy Technology Data Exchange (ETDEWEB)

    Rhen, I. [VBB Viak, Goeteborg (Sweden); Baeckbom, G. [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden)] [eds.; Gustafsson, Gunnar [VBB Viak, Goeteborg (Sweden) and Chalmers Univ. of Technology, Goeteborg (Sweden); Stanfors, R. [RS Consulting, Lund (Sweden); Wikberg, P. [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden)

    1997-05-01

    The work at Aespoe Hard rock laboratory provides an important scientific and technical basis for implementing and operating a future deep repository in Sweden. A milestone has now been reached with the completion of the pre investigation and construction phases at Aespoe HRL. The present data base at Aespoe HRL is one of the most comprehensive data bases in the world for crystalline rock properties, containing data from a large number of investigation methods from the surface down to 1700 m below ground level. Site characterization in conjunction with construction work has basically confirmed the pre-construction models. The site characterization has been a realistic `dress rehearsal` that is invaluable for planning and execution of surface and underground characterization of sites for the deep repository for spent nuclear fuel in Sweden. 502 refs, 114 figs, 30 tabs.

  5. 77 FR 22772 - Environmental Management Site-Specific Advisory Board

    Science.gov (United States)

    2012-04-17

    ... DEPARTMENT OF ENERGY Environmental Management Site-Specific Advisory Board AGENCY: Office of Environmental Management, Department of Energy. ACTION: Notice of renewal. SUMMARY: Pursuant to Section 14(a)(2... Secretariat, General Services Administration, notice is hereby given that the Environmental Management Site...

  6. Enhanced dimension-specific visual working memory in grapheme–color synesthesia☆

    Science.gov (United States)

    Terhune, Devin Blair; Wudarczyk, Olga Anna; Kochuparampil, Priya; Cohen Kadosh, Roi

    2013-01-01

    There is emerging evidence that the encoding of visual information and the maintenance of this information in a temporarily accessible state in working memory rely on the same neural mechanisms. A consequence of this overlap is that atypical forms of perception should influence working memory. We examined this by investigating whether having grapheme–color synesthesia, a condition characterized by the involuntary experience of color photisms when reading or representing graphemes, would confer benefits on working memory. Two competing hypotheses propose that superior memory in synesthesia results from information being coded in two information channels (dual-coding) or from superior dimension-specific visual processing (enhanced processing). We discriminated between these hypotheses in three n-back experiments in which controls and synesthetes viewed inducer and non-inducer graphemes and maintained color or grapheme information in working memory. Synesthetes displayed superior color working memory than controls for both grapheme types, whereas the two groups did not differ in grapheme working memory. Further analyses excluded the possibilities of enhanced working memory among synesthetes being due to greater color discrimination, stimulus color familiarity, or bidirectionality. These results reveal enhanced dimension-specific visual working memory in this population and supply further evidence for a close relationship between sensory processing and the maintenance of sensory information in working memory. PMID:23892185

  7. Remedial action work plan for the Colonie site. Revision 1

    International Nuclear Information System (INIS)

    1985-08-01

    The Colonie site is a DOE Formerly Utilized Sites Remedial Action Program (FUSRAP) site located in the Town of Colonie, New York, and consisting of an interim storage site and several vicinity properties. The Colonie Interim Storage Site (CISS) is the former National Lead (NL) Industries plant located at 1130 Central Avenue. There are 11 vicinity properties that received remedial action in 1984: 7 located south of the site on Yardboro and Palmer Avenues just across the Colonie-Albany town limits in Albany, and 4 located northwest of the site along Central Avenue in Colonie. Of these properties, nine are residences and two are commercial properties. This document describes the engineering design, construction, and associated plans for remedial action on the vicinity properties and the interim storage site. These plans include both radiological and chemical work. Radiological work includes: excavating the above-guideline radioactive wastes on the vicinity properties; designing required facilities for the interim storage site; preparing the interim storage site to receive these contaminated materials; transporting the contaminated materials to the interim waste storage stockpile; and preparing necessary schedules for accomplishing the remedial actions. Chemical work involves: developing the Resource Conservation and Recovery Act (RCRA) closure plans; neutralizing chemical hazards associated with plating solutions; inventorying on-site chemicals; and disposal of chemicals and/or residues. 17 refs., 5 figs., 1 tab

  8. Near Regional and Site Investigations of the Temelin NPP Site

    International Nuclear Information System (INIS)

    Prachar, Ivan; Vacek, Jiri; Heralecky, Pavel

    2011-01-01

    The Temelin NPP is worldwide through heated discussion with nuclear energetic opposition. In addition this discussion goes beyond a border of the Czech Republic. On the other side, results of several international supervisions shown that Temelin NPP is fully comparable with the safest nuclear power plants in the world regarding its technical design and safety functions. This presentation deals with the near regional and site investigations of the Temelin NPP Site. It must be noted that although the Temelin site is situated in the area with low seismicity, item of seismicity is a basic argument against Temelin NPP and therefore a detail seismic hazard assessment was performed

  9. Technical specifications for the Pajarito Site Critical Experiments Facility

    International Nuclear Information System (INIS)

    Malenfant, R.E.; Paxton, H.C.

    1980-12-01

    This document is to satisfy the requirement for technical specifications spelled out in DOE Manual Chapter 0540, Safety of DOE-Owned Reactors. Technical specifications are defined in Sec. 0540-048, and the requirement for them appears in Sec. 0540-015. The following technical specifications update the document, Technical Specifications for the Pajarito Site Critical Experiments Facility

  10. Savannah River Site RCRA Facility Investigation plan: Road A Chemical Basin

    International Nuclear Information System (INIS)

    1989-06-01

    The nature of wastes disposed of at the Road A Chemical Basin (RACB) is such that some degree of soil contamination is probable. Lead has also been detected in site monitoring wells at concentrations above SRS background levels. A RCRA Facility Investigation (RFI) is proposed for the RACB and will include a ground penetrating radar (GPR) survey, collection and chemical and radiological analyses of soil cores, installation of groundwater monitoring wells, collection and chemical and radiological analyses of groundwater samples, and collection of chemical and radiological analyses of surface water and sediment samples. Upon completion of the proposed RFI field work and chemical and radiological analyses, and RFI report should be prepared to present conclusions on the nature and extent of contamination at the site, and to make recommendations for site remediation. If contamination is detected at concentrations above SRS background levels, a receptor analysis should be done to evaluate potential impacts of site contamination on nearby populations

  11. Bioavailability of particulate metal to zebra mussels: Biodynamic modelling shows that assimilation efficiencies are site-specific

    Energy Technology Data Exchange (ETDEWEB)

    Bourgeault, Adeline, E-mail: bourgeault@ensil.unilim.fr [Cemagref, Unite de Recherche Hydrosystemes et Bioprocedes, 1 rue Pierre-Gilles de Gennes, 92761 Antony (France); FIRE, FR-3020, 4 place Jussieu, 75005 Paris (France); Gourlay-France, Catherine, E-mail: catherine.gourlay@cemagref.fr [Cemagref, Unite de Recherche Hydrosystemes et Bioprocedes, 1 rue Pierre-Gilles de Gennes, 92761 Antony (France); FIRE, FR-3020, 4 place Jussieu, 75005 Paris (France); Priadi, Cindy, E-mail: cindy.priadi@eng.ui.ac.id [LSCE/IPSL CEA-CNRS-UVSQ, Avenue de la Terrasse, 91198 Gif-sur-Yvette (France); Ayrault, Sophie, E-mail: Sophie.Ayrault@lsce.ipsl.fr [LSCE/IPSL CEA-CNRS-UVSQ, Avenue de la Terrasse, 91198 Gif-sur-Yvette (France); Tusseau-Vuillemin, Marie-Helene, E-mail: Marie-helene.tusseau@ifremer.fr [IFREMER Technopolis 40, 155 rue Jean-Jacques Rousseau, 92138 Issy-Les-Moulineaux (France)

    2011-12-15

    This study investigates the ability of the biodynamic model to predict the trophic bioaccumulation of cadmium (Cd), chromium (Cr), copper (Cu), nickel (Ni) and zinc (Zn) in a freshwater bivalve. Zebra mussels were transplanted to three sites along the Seine River (France) and collected monthly for 11 months. Measurements of the metal body burdens in mussels were compared with the predictions from the biodynamic model. The exchangeable fraction of metal particles did not account for the bioavailability of particulate metals, since it did not capture the differences between sites. The assimilation efficiency (AE) parameter is necessary to take into account biotic factors influencing particulate metal bioavailability. The biodynamic model, applied with AEs from the literature, overestimated the measured concentrations in zebra mussels, the extent of overestimation being site-specific. Therefore, an original methodology was proposed for in situ AE measurements for each site and metal. - Highlights: > Exchangeable fraction of metal particles did not account for the bioavailability of particulate metals. > Need for site-specific biodynamic parameters. > Field-determined AE provide a good fit between the biodynamic model predictions and bioaccumulation measurements. - The interpretation of metal bioaccumulation in transplanted zebra mussels with biodynamic modelling highlights the need for site-specific assimilation efficiencies of particulate metals.

  12. Site investigations for final disposal of high-level nuclear waste

    International Nuclear Information System (INIS)

    Aeikaes, T.; Laine, T.

    1982-12-01

    Research concerning disposal of high-level nuclear waste of the Industrial Power Company Ltd has focused on deep underground disposal in Finnish precambrian bedrock. The present target is to have a repository for high-level waste in operation by 2020. Selection of the repository site is based on site investigations. In addition to geosciences, selection of appropriate site includes many branches of studies; engineering, safety analysis, ecology, transport, demography etc. The investigations required for site selection for high-level waste have been arranged in a sequence of four phases. The aim of the phases is that investigations become more and more detailed as the selection process continues. Phase I of the investigations is the characterization of potential areas. This comprises establishment of criteria for site selection and identification of areas that meet selection criteria. Objective of these studies is to determine areas for phase II field investigations. The studies are largely made by reviewing existing data and remote-sensing techniques. Phase II field investigations will be undertaken between 1986-1992. The number of potential candidates for repository site is reduced to few preferred areas by preceeding generic study. The site selection process culminates in phase III in site confirmation studies carried out at 2...3 most suitable sites during 1992-2010. This is then followed by phase IV, which comprises very detailed investigations at the selected site. An alternative for these investigations is to undertake them by using pilot shaft and drifts. Active development is taking place in all phases concerning investigation methods, criteria, parameters, data processing and modelling. The applicability of the various investigation methods and techniques is tested in a deep borehole in phase I. The co-operation with countries with similar geological conditions makes it possible to compare results obtained by different techniques

  13. Appreciating Site-Specific Qualities in Urban Harbours

    DEFF Research Database (Denmark)

    Reeh, Henrik

    2015-01-01

    of observa-tions from Marseille in southern France. After modernization and dislocation of its harbor territories in the early 20th century already, this city is currently taking important steps from industrial urbanism into cultural planning. This transformation allows for new and unprogrammed experiences......When “site-specificity” becomes a central value in city and harbor transformation, it soon proves necessary to address the ways in which scholars and professionals actually determine site-specific qualities in urban fabrics and social life. This paper delves into the above questions by means...

  14. Analysis of Critical Issues in Biosphere Assessment Modelling and Site Investigation

    Energy Technology Data Exchange (ETDEWEB)

    Egan, M.J.; Thorne, M.C.; Little, R.H.; Pasco, R.F. [Quintessa Limited, Henley-on-Thames (United Kingdom)

    2003-07-01

    The aim of this document is to present a critical review of issues concerned with the treatment of the biosphere and geosphere-biosphere interface in long-term performance assessment studies for nuclear waste disposal in Sweden. The review covers three main areas of investigation: a review of SKB's plans for undertaking site investigations at candidate locations for the development of a deep geological repository for spent fuel; identification of critical uncertainties associated with SKB's treatment of the geosphere-biosphere interface in recent performance assessments; and a preliminary modelling investigation of the significance of features, events and processes in the near-surface environment in terms of their effect on the accumulation and redistribution of radionuclides at the geosphere-biosphere interface. Overall, SKB's proposals for site investigations are considered to be comprehensive and, if they can be carried out to the specification presented, will constitute a benchmark that other waste management organisations will have to work hard to emulate. The main concern is that expertise for undertaking the investigations and reporting the results could be stretched very thin. The authors have also identified weaknesses in the documentation concerning the collection of evidence for environmental change and on developing scenarios for future environmental change. A fundamental assumption adopted in the renewed assessment of the SFR 1 repository, which is not discussed or justified in any of the documentation that has been reviewed, is that radionuclides enter the water column of the coastal and lake models directly, without passing first through the bed sediments. The modelling study reported herein suggests that SKB's models are robust to range of alternative conceptual descriptions relating to the geosphere-biosphere interface. There are however situations, in which contaminated groundwater is released via sediment rather than directly

  15. Analysis of Critical Issues in Biosphere Assessment Modelling and Site Investigation

    International Nuclear Information System (INIS)

    Egan, M.J.; Thorne, M.C.; Little, R.H.; Pasco, R.F.

    2003-07-01

    The aim of this document is to present a critical review of issues concerned with the treatment of the biosphere and geosphere-biosphere interface in long-term performance assessment studies for nuclear waste disposal in Sweden. The review covers three main areas of investigation: a review of SKB's plans for undertaking site investigations at candidate locations for the development of a deep geological repository for spent fuel; identification of critical uncertainties associated with SKB's treatment of the geosphere-biosphere interface in recent performance assessments; and a preliminary modelling investigation of the significance of features, events and processes in the near-surface environment in terms of their effect on the accumulation and redistribution of radionuclides at the geosphere-biosphere interface. Overall, SKB's proposals for site investigations are considered to be comprehensive and, if they can be carried out to the specification presented, will constitute a benchmark that other waste management organisations will have to work hard to emulate. The main concern is that expertise for undertaking the investigations and reporting the results could be stretched very thin. The authors have also identified weaknesses in the documentation concerning the collection of evidence for environmental change and on developing scenarios for future environmental change. A fundamental assumption adopted in the renewed assessment of the SFR 1 repository, which is not discussed or justified in any of the documentation that has been reviewed, is that radionuclides enter the water column of the coastal and lake models directly, without passing first through the bed sediments. The modelling study reported herein suggests that SKB's models are robust to range of alternative conceptual descriptions relating to the geosphere-biosphere interface. There are however situations, in which contaminated groundwater is released via sediment rather than directly to the water column

  16. Pinellas Plant FY1990 site specific implementation plan

    International Nuclear Information System (INIS)

    Klein, R.D.

    1990-02-01

    This Site Specific Implementation Plan describes the Corrective Action, Environmental Restoration, and Waste Management activities to be performed at the Pinellas Plant in FY1990 (October 1, 1989 to September 30, 1989). These FY1990 activities are described in the Pinellas Plant FY1991--95 Five-Year Plan. The information used to prepare this plan reflects the best estimate of the project scope, schedules, regulatory, and funding requirements at the time of plan preparation. The Environmental Restoration/Waste Management Five-Year Plan is a dynamic document and will be modified each year; the Site Specific Implementation Plan will, in turn, be modified each year to reflect new findings, information, and knowledge of the various projects. 4 figs., 11 tabs

  17. Unusual Structure of the attB Site of the Site-Specific Recombination System of Lactobacillus delbrueckii Bacteriophage mv4

    Science.gov (United States)

    Auvray, Frédéric; Coddeville, Michèle; Ordonez, Romy Catoira; Ritzenthaler, Paul

    1999-01-01

    The temperate phage mv4 integrates its genome into the chromosome of Lactobacillus delbrueckii subsp. bulgaricus by site-specific recombination within the 3′ end of a tRNASer gene. Recombination is catalyzed by the phage-encoded integrase and occurs between the phage attP site and the bacterial attB site. In this study, we show that the mv4 integrase functions in vivo in Escherichia coli and we characterize the bacterial attB site with a site-specific recombination test involving compatible plasmids carrying the recombination sites. The importance of particular nucleotides within the attB sequence was determined by site-directed mutagenesis. The structure of the attB site was found to be simple but rather unusual. A 16-bp DNA fragment was sufficient for function. Unlike most genetic elements that integrate their DNA into tRNA genes, none of the dyad symmetry elements of the tRNASer gene were present within the minimal attB site. No inverted repeats were detected within this site either, in contrast to the lambda site-specific recombination model. PMID:10572145

  18. Site Characterization Work Plan for the Gnome-Coach Site, New Mexico (Rev. 1, January 2002)

    Energy Technology Data Exchange (ETDEWEB)

    U.S. Department of Energy, National Nuclear Security Administration Nevada Operations Office (NNSA/NV)

    2002-01-14

    Project Gnome was the first nuclear experiment conducted under the U.S. Atomic Energy Commission (AEC), predecessor to the U.S. Department of Energy (DOE), Plowshare Program. The Plowshare Program focused on developing nuclear devices exclusively for peaceful purposes. The intent of the Gnome experiment was to evaluate the effects of a nuclear detonation in a salt medium. Historically, Project Gnome consisted of a single detonation of a nuclear device on December 10, 1961 with the Salado Formation. Since the Gnome detonation, the AEC/DOE has conducted surface restoration, site reconnaissance, and decontamination and decommissioning activities at the site. In addition, annual groundwater sampling is performed under a long-term hydrological monitoring program begun in 1972. Coach, an experiment to be located near the Gnome project, was initially scheduled for 1963. Although construction and rehabilitation were completed for Coach, the experiment was canceled and never executed. Known collectively as Project Gnome-Coach, the site is located approximately 25 miles east of Carlsbad, New Mexico, in Eddy County, and is comprised of nearly 680 acres, of which approximately 60 acres are disturbed from the combined AEC/DOE operations. The scope of this work plan is to document the environmental objectives and the proposed technical site investigation strategies that will be utilized for the site characterization of the project. The subsurface at the Gnome-Coach site has two contaminant sources that are fundamentally different in terms of both their stratigraphic location and release mechanism. The goal of this characterization is to collect data of sufficient quantity and quality to establish current site conditions and to use the data to identify and evaluate if further action is required to protect human health and the environment and achieve permanent closure of the site. The results of these activities will be presented in a subsequent corrective action decision document.

  19. Site-specific proteolytic degradation of IgG monoclonal antibodies expressed in tobacco plants.

    Science.gov (United States)

    Hehle, Verena K; Lombardi, Raffaele; van Dolleweerd, Craig J; Paul, Mathew J; Di Micco, Patrizio; Morea, Veronica; Benvenuto, Eugenio; Donini, Marcello; Ma, Julian K-C

    2015-02-01

    Plants are promising hosts for the production of monoclonal antibodies (mAbs). However, proteolytic degradation of antibodies produced both in stable transgenic plants and using transient expression systems is still a major issue for efficient high-yield recombinant protein accumulation. In this work, we have performed a detailed study of the degradation profiles of two human IgG1 mAbs produced in plants: an anti-HIV mAb 2G12 and a tumour-targeting mAb H10. Even though they use different light chains (κ and λ, respectively), the fragmentation pattern of both antibodies was similar. The majority of Ig fragments result from proteolytic degradation, but there are only a limited number of plant proteolytic cleavage events in the immunoglobulin light and heavy chains. All of the cleavage sites identified were in the proximity of interdomain regions and occurred at each interdomain site, with the exception of the VL /CL interface in mAb H10 λ light chain. Cleavage site sequences were analysed, and residue patterns characteristic of proteolytic enzymes substrates were identified. The results of this work help to define common degradation events in plant-produced mAbs and raise the possibility of predicting antibody degradation patterns 'a priori' and designing novel stabilization strategies by site-specific mutagenesis. © 2014 Society for Experimental Biology, Association of Applied Biologists and John Wiley & Sons Ltd.

  20. Site investigation SFR. Bedrock geology

    International Nuclear Information System (INIS)

    Curtis, Philip; Markstroem, Ingemar; Petersson, Jesper; Triumf, Carl-Axel; Isaksson, Hans; Mattsson, Haakan

    2011-12-01

    geological tunnel mapping and eleven drill cores remapped according to the Boremap system, input to model version 1.0 has included the results from eight new cored boreholes as well as a fuller integration of Forsmark site investigation data, a further more extensive review of the drill core from an additional 32 boreholes associated with the construction of the existing SFR facility and an updated mapping of the lower construction tunnel. The current modelling work has also reviewed the older SFR data and models. While details concerning the earlier zones lying in immediate contact with the existing SFR facility have been changed, the earlier overall position, orientation and number of these deformation zones is maintained. A significant difference concerns their thickness due to the contrasting methodologies used during the different campaigns. In SFR model version 0.1, a single deformation zone model was produced, with a volume corresponding to the regional model volume. The model contained all the deformation zones modelled irrespective of size. Separate local and regional deformation zone models have been produced in SFR model version 1.0, following resolution criteria for the different model volumes. The local model contains zones with a minimum size of 300 m, while the regional model has structures that have a minimum size constraint of 1,000 m trace length at the ground surface. The selection of these size limits is related to the model volume maximum depth (local model -300 masl and regional model -1,000 masl) and the applied methodology that requires the same model resolution throughout the defined model volume (see Section 5.3.1). To assist hydrogeological modelling work, an updated combined model, including all structures from both the regional and local models, has also been delivered. The existing SFR facility and the rock volume directly to the south-east, which is proposed for the new facility extension, lies within a tectonic block that is bounded to the

  1. Site investigation SFR. Bedrock geology

    Energy Technology Data Exchange (ETDEWEB)

    Curtis, Philip; Markstroem, Ingemar (Golder Associates AB (Sweden)); Petersson, Jesper (Vattenfall Power Consultant AB (Sweden)); Triumf, Carl-Axel; Isaksson, Hans; Mattsson, Haakan (GeoVista AB (Sweden))

    2011-12-15

    the geological tunnel mapping and eleven drill cores remapped according to the Boremap system, input to model version 1.0 has included the results from eight new cored boreholes as well as a fuller integration of Forsmark site investigation data, a further more extensive review of the drill core from an additional 32 boreholes associated with the construction of the existing SFR facility and an updated mapping of the lower construction tunnel. The current modelling work has also reviewed the older SFR data and models. While details concerning the earlier zones lying in immediate contact with the existing SFR facility have been changed, the earlier overall position, orientation and number of these deformation zones is maintained. A significant difference concerns their thickness due to the contrasting methodologies used during the different campaigns. In SFR model version 0.1, a single deformation zone model was produced, with a volume corresponding to the regional model volume. The model contained all the deformation zones modelled irrespective of size. Separate local and regional deformation zone models have been produced in SFR model version 1.0, following resolution criteria for the different model volumes. The local model contains zones with a minimum size of 300 m, while the regional model has structures that have a minimum size constraint of 1,000 m trace length at the ground surface. The selection of these size limits is related to the model volume maximum depth (local model -300 masl and regional model -1,000 masl) and the applied methodology that requires the same model resolution throughout the defined model volume (see Section 5.3.1). To assist hydrogeological modelling work, an updated combined model, including all structures from both the regional and local models, has also been delivered. The existing SFR facility and the rock volume directly to the south-east, which is proposed for the new facility extension, lies within a tectonic block that is bounded

  2. RCRA Facility Investigation/Remedial Investigation Report for the Grace Road Site (631-22G)

    Energy Technology Data Exchange (ETDEWEB)

    Palmer, E.

    1998-10-02

    This report summarizes the activities and documents the results of a Resource Conservation and Recovery Act Facility Investigation/Remedial Investigation conducted at Grace Road Site on the Savannah River Site near Aiken, South Carolina.

  3. RCRA Facility Investigation/Remedial Investigation Report for the Grace Road Site (631-22G)

    International Nuclear Information System (INIS)

    Palmer, E.

    1998-01-01

    This report summarizes the activities and documents the results of a Resource Conservation and Recovery Act Facility Investigation/Remedial Investigation conducted at Grace Road Site on the Savannah River Site near Aiken, South Carolina

  4. Potentials for site-specific design of MW sized wind turbines

    DEFF Research Database (Denmark)

    Thomsen, K.; Fuglsang, P.; Schepers, G.

    2001-01-01

    The potential for site specific design of MW sized wind turbines is quantified by comparing design loads for wind turbines installed at a range of different sites. The sites comprise on-shore normal flat terrain stand-alone conditions and wind farm conditions together with offshore and mountainous...

  5. Hydrogeochemical site descriptive model - a strategy for the model development during site investigations

    Energy Technology Data Exchange (ETDEWEB)

    Smellie, John [Conterra AB, Uppsala (Sweden); Laaksoharju, Marcus [GeoPoint AB, Sollentuna (Sweden); Tullborg, Eva-Lena [Terralogica AB, Graabo (Sweden)

    2002-12-01

    In 2002, SKB commenced site characterisation investigations using deep boreholes at different sites. As an integral part of the planning work SKB has prepared a strategy to develop a Hydrogeochemical Site Descriptive Model; similar strategies have been developed for the other major geoscience disciplines. The main objectives of the Hydrogeochemical Site Descriptive Model are to describe the chemistry and distribution of the groundwater in the bedrock and overburden and the hydrogeochemical processes involved in its origin and evolution. This description is based primarily on measurements of the groundwater composition but incorporates the use of available geological and hydrogeological site descriptive models. The SKB hydrogeochemistry programme is planned to fulfil two basic requirements: 1) to provide representative and quality assured data for use as input parameter values in calculating long-term repository safety, and 2) to understand the present undisturbed hydrogeochemical conditions and how these conditions will change in the future. Parameter values for safety analysis include pH, Eh, S, SO{sub 4}, HCO{sub 3}, HPO{sub 4} and TDS (mainly cations), together with colloids, fulvic and humic acids, other organics, bacteria and nitrogen. These values will be used to characterise the groundwater environment at, above and below repository depths. In the hydrogeochemical site investigation programme the number and location of the sampling points will be constrained by: a) geology (e.g. topography, overburden types, bedrock structures etc), b) hydrogeology (e.g. groundwater recharge/discharge areas, residence times), c) reliability (e.g. undisturbed vs disturbed groundwater chemical conditions), and d) resources (e.g. number and type of samples, and also available personnel, may be restricted by budgetary and schedule concerns). Naturally a balance is required between these constraints and the scientific aims of the programme. The constraints should never

  6. Predicting on-site environmental impacts of municipal engineering works

    International Nuclear Information System (INIS)

    Gangolells, Marta; Casals, Miquel; Forcada, Núria; Macarulla, Marcel

    2014-01-01

    The research findings fill a gap in the body of knowledge by presenting an effective way to evaluate the significance of on-site environmental impacts of municipal engineering works prior to the construction stage. First, 42 on-site environmental impacts of municipal engineering works were identified by means of a process-oriented approach. Then, 46 indicators and their corresponding significance limits were determined on the basis of a statistical analysis of 25 new-build and remodelling municipal engineering projects. In order to ensure the objectivity of the assessment process, direct and indirect indicators were always based on quantitative data from the municipal engineering project documents. Finally, two case studies were analysed and found to illustrate the practical use of the proposed model. The model highlights the significant environmental impacts of a particular municipal engineering project prior to the construction stage. Consequently, preventive actions can be planned and implemented during on-site activities. The results of the model also allow a comparison of proposed municipal engineering projects and alternatives with respect to the overall on-site environmental impact and the absolute importance of a particular environmental aspect. These findings are useful within the framework of the environmental impact assessment process, as they help to improve the identification and evaluation of on-site environmental aspects of municipal engineering works. The findings may also be of use to construction companies that are willing to implement an environmental management system or simply wish to improve on-site environmental performance in municipal engineering projects. -- Highlights: • We present a model to predict the environmental impacts of municipal engineering works. • It highlights significant on-site environmental impacts prior to the construction stage. • Findings are useful within the environmental impact assessment process. • They also

  7. Predicting on-site environmental impacts of municipal engineering works

    Energy Technology Data Exchange (ETDEWEB)

    Gangolells, Marta, E-mail: marta.gangolells@upc.edu; Casals, Miquel, E-mail: miquel.casals@upc.edu; Forcada, Núria, E-mail: nuria.forcada@upc.edu; Macarulla, Marcel, E-mail: marcel.macarulla@upc.edu

    2014-01-15

    The research findings fill a gap in the body of knowledge by presenting an effective way to evaluate the significance of on-site environmental impacts of municipal engineering works prior to the construction stage. First, 42 on-site environmental impacts of municipal engineering works were identified by means of a process-oriented approach. Then, 46 indicators and their corresponding significance limits were determined on the basis of a statistical analysis of 25 new-build and remodelling municipal engineering projects. In order to ensure the objectivity of the assessment process, direct and indirect indicators were always based on quantitative data from the municipal engineering project documents. Finally, two case studies were analysed and found to illustrate the practical use of the proposed model. The model highlights the significant environmental impacts of a particular municipal engineering project prior to the construction stage. Consequently, preventive actions can be planned and implemented during on-site activities. The results of the model also allow a comparison of proposed municipal engineering projects and alternatives with respect to the overall on-site environmental impact and the absolute importance of a particular environmental aspect. These findings are useful within the framework of the environmental impact assessment process, as they help to improve the identification and evaluation of on-site environmental aspects of municipal engineering works. The findings may also be of use to construction companies that are willing to implement an environmental management system or simply wish to improve on-site environmental performance in municipal engineering projects. -- Highlights: • We present a model to predict the environmental impacts of municipal engineering works. • It highlights significant on-site environmental impacts prior to the construction stage. • Findings are useful within the environmental impact assessment process. • They also

  8. Phonological working memory and auditory processing speed in children with specific language impairment

    Directory of Open Access Journals (Sweden)

    Fatemeh Haresabadi

    2015-02-01

    Full Text Available Background and Aim: Specific language impairment (SLI, one variety of developmental language disorder, has attracted much interest in recent decades. Much research has been conducted to discover why some children have a specific language impairment. So far, research has failed to identify a reason for this linguistic deficiency. Some researchers believe language disorder causes defects in phonological working memory and affects auditory processing speed. Therefore, this study reviews the results of research investigating these two factors in children with specific language impairment.Recent Findings: Studies have shown that children with specific language impairment face constraints in phonological working memory capacity. Memory deficit is one possible cause of linguistic disorder in children with specific language impairment. However, in these children, disorder in information processing speed is observed, especially regarding the auditory aspect.Conclusion: Much more research is required to adequately explain the relationship between phonological working memory and auditory processing speed with language. However, given the role of phonological working memory and auditory processing speed in language acquisition, a focus should be placed on phonological working memory capacity and auditory processing speed in the assessment and treatment of children with a specific language impairment.

  9. Salmon Site Remedial Investigation Report, Appendix C

    International Nuclear Information System (INIS)

    1999-01-01

    This Salmon Site Remedial Investigation Report provides the results of activities initiated by the U.S. Department of Energy (DOE) to determine if contamination at the Salmon Site poses a current or future risk to human health and the environment. These results were used to develop and evaluate a range of risk-based remedial alternatives. Located in Lamar County, Mississippi, the Salmon Site was used by the U.S. Atomic Energy Commission (predecessor to the DOE) between 1964 and 1970 for two nuclear and two gas explosions conducted deep underground in a salt dome. The testing resulted in the release of radionuclides into the salt dome. During reentry drilling and other site activities, liquid and solid wastes containing radioactivity were generated resulting in surface soil and groundwater contamination. Most of the waste and contaminated soil and water were disposed of in 1993 during site restoration either in the cavities left by the tests or in an injection well. Other radioactive wastes were transported to the Nevada Test Site for disposal. Nonradioactive wastes were disposed of in pits at the site and capped with clean soil and graded. The preliminary investigation showed residual contamination in the Surface Ground Zero mud pits below the water table. Remedial investigations results concluded the contaminant concentrations detected present no significant risk to existing and/or future land users, if surface institutional controls and subsurface restrictions are maintained. Recent sampling results determined no significant contamination in the surface or shallow subsurface. The test cavity resulting from the experiments is contaminated and cannot be economically remediated with existing technologies. The ecological sampling did not detect biological uptake of contaminants in the plants or animals sampled. Based on the current use of the Salmon Site, the following remedial actions were identified to protect both human health and the environment: (1) the

  10. Salmon Site Remedial Investigation Report, Exhibit 2

    Energy Technology Data Exchange (ETDEWEB)

    USDOE NV

    1999-09-01

    This Salmon Site Remedial Investigation Report provides the results of activities initiated by the U.S. Department of Energy (DOE) to determine if contamination at the Salmon Site poses a current or future risk to human health and the environment. These results were used to develop and evaluate a range of risk-based remedial alternatives. Located in Lamar County, Mississippi, the Salmon Site was used by the U.S. Atomic Energy Commission (predecessor to the DOE) between 1964 and 1970 for two nuclear and two gas explosions conducted deep underground in a salt dome. The testing resulted in the release of radionuclides into the salt dome. During reentry drilling and other site activities, liquid and solid wastes containing radioactivity were generated resulting in surface soil and groundwater contamination. Most of the waste and contaminated soil and water were disposed of in 1993 during site restoration either in the cavities left by the tests or in an injection well. Other radioactive wastes were transported to the Nevada Test Site for disposal. Nonradioactive wastes were disposed of in pits at the site and capped with clean soil and graded. The preliminary investigation showed residual contamination in the Surface Ground Zero mud pits below the water table. Remedial investigations results concluded the contaminant concentrations detected present no significant risk to existing and/or future land users, if surface institutional controls and subsurface restrictions are maintained. Recent sampling results determined no significant contamination in the surface or shallow subsurface. The test cavity resulting from the experiments is contaminated and cannot be economically remediated with existing technologies. The ecological sampling did not detect biological uptake of contaminants in the plants or animals sampled. Based on the current use of the Salmon Site, the following remedial actions were identified to protect both human health and the environment: (1) the

  11. Salmon Site Remedial Investigation Report, Appendix D

    International Nuclear Information System (INIS)

    1999-01-01

    This Salmon Site Remedial Investigation Report provides the results of activities initiated by the U.S. Department of Energy (DOE) to determine if contamination at the Salmon Site poses a current or future risk to human health and the environment. These results were used to develop and evaluate a range of risk-based remedial alternatives. Located in Lamar County, Mississippi, the Salmon Site was used by the U.S. Atomic Energy Commission (predecessor to the DOE) between 1964 and 1970 for two nuclear and two gas explosions conducted deep underground in a salt dome. The testing resulted in the release of radionuclides into the salt dome. During reentry drilling and other site activities, liquid and solid wastes containing radioactivity were generated resulting in surface soil and groundwater contamination. Most of the waste and contaminated soil and water were disposed of in 1993 during site restoration either in the cavities left by the tests or in an injection well. Other radioactive wastes were transported to the Nevada Test Site for disposal. Nonradioactive wastes were disposed of in pits at the site and capped with clean soil and graded. The preliminary investigation showed residual contamination in the Surface Ground Zero mud pits below the water table. Remedial investigations results concluded the contaminant concentrations detected present no significant risk to existing and/or future land users, if surface institutional controls and subsurface restrictions are maintained. Recent sampling results determined no significant contamination in the surface or shallow subsurface. The test cavity resulting from the experiments is contaminated and cannot be economically remediated with existing technologies. The ecological sampling did not detect biological uptake of contaminants in the plants or animals sampled. Based on the current use of the Salmon Site, the following remedial actions were identified to protect both human health and the environment: (1) the

  12. Salmon Site Remediation Investigation Report, Appendix A

    International Nuclear Information System (INIS)

    1999-01-01

    This Salmon Site Remedial Investigation Report provides the results of activities initiated by the U.S. Department of Energy (DOE) to determine if contamination at the Salmon Site poses a current or future risk to human health and the environment. These results were used to develop and evaluate a range of risk-based remedial alternatives. Located in Lamar County, Mississippi, the Salmon Site was used by the U.S. Atomic Energy Commission (predecessor to the DOE) between 1964 and 1970 for two nuclear and two gas explosions conducted deep underground in a salt dome. The testing resulted in the release of radionuclides into the salt dome. During reentry drilling and other site activities, liquid and solid wastes containing radioactivity were generated resulting in surface soil and groundwater contamination. Most of the waste and contaminated soil and water were disposed of in 1993 during site restoration either in the cavities left by the tests or in an injection well. Other radioactive wastes were transported to the Nevada Test Site for disposal. Nonradioactive wastes were disposed of in pits at the site and capped with clean soil and graded. The preliminary investigation showed residual contamination in the Surface Ground Zero mud pits below the water table. Remedial investigations results concluded the contaminant concentrations detected present no significant risk to existing and/or future land users, if surface institutional controls and subsurface restrictions are maintained. Recent sampling results determined no significant contamination in the surface or shallow subsurface. The test cavity resulting from the experiments is contaminated and cannot be economically remediated with existing technologies. The ecological sampling did not detect biological uptake of contaminants in the plants or animals sampled. Based on the current use of the Salmon Site, the following remedial actions were identified to protect both human health and the environment: (1) the

  13. Salmon Site Remedial Investigation Report, Main Body

    Energy Technology Data Exchange (ETDEWEB)

    US DOE/NV

    1999-09-01

    This Salmon Site Remedial Investigation Report provides the results of activities initiated by the U.S. Department of Energy (DOE) to determine if contamination at the Salmon Site poses a current or future risk to human health and the environment. These results were used to develop and evaluate a range of risk-based remedial alternatives. Located in Lamar County, Mississippi, the Salmon Site was used by the U.S. Atomic Energy Commission (predecessor to the DOE) between 1964 and 1970 for two nuclear and two gas explosions conducted deep underground in a salt dome. The testing resulted in the release of radionuclides into the salt dome. During reentry drilling and other site activities, liquid and solid wastes containing radioactivity were generated resulting in surface soil and groundwater contamination. Most of the waste and contaminated soil and water were disposed of in 1993 during site restoration either in the cavities left by the tests or in an injection well. Other radioactive wastes were transported to the Nevada Test Site for disposal. Nonradioactive wastes were disposed of in pits at the site and capped with clean soil and graded. The preliminary investigation showed residual contamination in the Surface Ground Zero mud pits below the water table. Remedial investigations results concluded the contaminant concentrations detected present no significant risk to existing and/or future land users, if surface institutional controls and subsurface restrictions are maintained. Recent sampling results determined no significant contamination in the surface or shallow subsurface. The test cavity resulting from the experiments is contaminated and cannot be economically remediated with existing technologies. The ecological sampling did not detect biological uptake of contaminants in the plants or animals sampled. Based on the current use of the Salmon Site, the following remedial actions were identified to protect both human health and the environment: (1) the

  14. Salmon Site Remedial Investigation Report, Exhibit 2

    International Nuclear Information System (INIS)

    1999-01-01

    This Salmon Site Remedial Investigation Report provides the results of activities initiated by the U.S. Department of Energy (DOE) to determine if contamination at the Salmon Site poses a current or future risk to human health and the environment. These results were used to develop and evaluate a range of risk-based remedial alternatives. Located in Lamar County, Mississippi, the Salmon Site was used by the U.S. Atomic Energy Commission (predecessor to the DOE) between 1964 and 1970 for two nuclear and two gas explosions conducted deep underground in a salt dome. The testing resulted in the release of radionuclides into the salt dome. During reentry drilling and other site activities, liquid and solid wastes containing radioactivity were generated resulting in surface soil and groundwater contamination. Most of the waste and contaminated soil and water were disposed of in 1993 during site restoration either in the cavities left by the tests or in an injection well. Other radioactive wastes were transported to the Nevada Test Site for disposal. Nonradioactive wastes were disposed of in pits at the site and capped with clean soil and graded. The preliminary investigation showed residual contamination in the Surface Ground Zero mud pits below the water table. Remedial investigations results concluded the contaminant concentrations detected present no significant risk to existing and/or future land users, if surface institutional controls and subsurface restrictions are maintained. Recent sampling results determined no significant contamination in the surface or shallow subsurface. The test cavity resulting from the experiments is contaminated and cannot be economically remediated with existing technologies. The ecological sampling did not detect biological uptake of contaminants in the plants or animals sampled. Based on the current use of the Salmon Site, the following remedial actions were identified to protect both human health and the environment: (1) the

  15. Salmon Site Remedial Investigation Report, Appendix C

    Energy Technology Data Exchange (ETDEWEB)

    US DOE/NV

    1999-09-01

    This Salmon Site Remedial Investigation Report provides the results of activities initiated by the U.S. Department of Energy (DOE) to determine if contamination at the Salmon Site poses a current or future risk to human health and the environment. These results were used to develop and evaluate a range of risk-based remedial alternatives. Located in Lamar County, Mississippi, the Salmon Site was used by the U.S. Atomic Energy Commission (predecessor to the DOE) between 1964 and 1970 for two nuclear and two gas explosions conducted deep underground in a salt dome. The testing resulted in the release of radionuclides into the salt dome. During reentry drilling and other site activities, liquid and solid wastes containing radioactivity were generated resulting in surface soil and groundwater contamination. Most of the waste and contaminated soil and water were disposed of in 1993 during site restoration either in the cavities left by the tests or in an injection well. Other radioactive wastes were transported to the Nevada Test Site for disposal. Nonradioactive wastes were disposed of in pits at the site and capped with clean soil and graded. The preliminary investigation showed residual contamination in the Surface Ground Zero mud pits below the water table. Remedial investigations results concluded the contaminant concentrations detected present no significant risk to existing and/or future land users, if surface institutional controls and subsurface restrictions are maintained. Recent sampling results determined no significant contamination in the surface or shallow subsurface. The test cavity resulting from the experiments is contaminated and cannot be economically remediated with existing technologies. The ecological sampling did not detect biological uptake of contaminants in the plants or animals sampled. Based on the current use of the Salmon Site, the following remedial actions were identified to protect both human health and the environment: (1) the

  16. Salmon Site Remedial Investigation Report, Exhibit 5

    Energy Technology Data Exchange (ETDEWEB)

    USDOE/NV

    1999-09-01

    This Salmon Site Remedial Investigation Report provides the results of activities initiated by the U.S. Department of Energy (DOE) to determine if contamination at the Salmon Site poses a current or future risk to human health and the environment. These results were used to develop and evaluate a range of risk-based remedial alternatives. Located in Lamar County, Mississippi, the Salmon Site was used by the U.S. Atomic Energy Commission (predecessor to the DOE) between 1964 and 1970 for two nuclear and two gas explosions conducted deep underground in a salt dome. The testing resulted in the release of radionuclides into the salt dome. During reentry drilling and other site activities, liquid and solid wastes containing radioactivity were generated resulting in surface soil and groundwater contamination. Most of the waste and contaminated soil and water were disposed of in 1993 during site restoration either in the cavities left by the tests or in an injection well. Other radioactive wastes were transported to the Nevada Test Site for disposal. Nonradioactive wastes were disposed of in pits at the site and capped with clean soil and graded. The preliminary investigation showed residual contamination in the Surface Ground Zero mud pits below the water table. Remedial investigations results concluded the contaminant concentrations detected present no significant risk to existing and/or future land users, if surface institutional controls and subsurface restrictions are maintained. Recent sampling results determined no significant contamination in the surface or shallow subsurface. The test cavity resulting from the experiments is contaminated and cannot be economically remediated with existing technologies. The ecological sampling did not detect biological uptake of contaminants in the plants or animals sampled. Based on the current use of the Salmon Site, the following remedial actions were identified to protect both human health and the environment: (1) the

  17. Salmon Site Remedial Investigation Report, Exhibit 5

    International Nuclear Information System (INIS)

    1999-01-01

    This Salmon Site Remedial Investigation Report provides the results of activities initiated by the U.S. Department of Energy (DOE) to determine if contamination at the Salmon Site poses a current or future risk to human health and the environment. These results were used to develop and evaluate a range of risk-based remedial alternatives. Located in Lamar County, Mississippi, the Salmon Site was used by the U.S. Atomic Energy Commission (predecessor to the DOE) between 1964 and 1970 for two nuclear and two gas explosions conducted deep underground in a salt dome. The testing resulted in the release of radionuclides into the salt dome. During reentry drilling and other site activities, liquid and solid wastes containing radioactivity were generated resulting in surface soil and groundwater contamination. Most of the waste and contaminated soil and water were disposed of in 1993 during site restoration either in the cavities left by the tests or in an injection well. Other radioactive wastes were transported to the Nevada Test Site for disposal. Nonradioactive wastes were disposed of in pits at the site and capped with clean soil and graded. The preliminary investigation showed residual contamination in the Surface Ground Zero mud pits below the water table. Remedial investigations results concluded the contaminant concentrations detected present no significant risk to existing and/or future land users, if surface institutional controls and subsurface restrictions are maintained. Recent sampling results determined no significant contamination in the surface or shallow subsurface. The test cavity resulting from the experiments is contaminated and cannot be economically remediated with existing technologies. The ecological sampling did not detect biological uptake of contaminants in the plants or animals sampled. Based on the current use of the Salmon Site, the following remedial actions were identified to protect both human health and the environment: (1) the

  18. Site Characterization Work Plan for Gasbuggy, New Mexico (Rev.1, Jan. 2002)

    Energy Technology Data Exchange (ETDEWEB)

    U.S. Department of Energy, National Nuclear Security Administration Nevada Operations Office (NNSA/NV)

    2002-01-25

    Project Gasbuggy was the first of three joint government-industry experiments conducted to test the effectiveness of nuclear explosives to fracture deeply buried, low-permeability natural gas reservoirs to stimulate production. The scope of this work plan is to document the environmental objectives and the proposed technical site investigation strategies that will be utilized for the site characterization of the Project Gasbuggy Site. Its goal is the collection of data in sufficient quantity and quality to determine current site conditions, support a risk assessment for the site surfaces, and evaluate if further remedial action is required to achieve permanent closure of the site that is both protective of human health and the environment. The Gasbuggy Site is located approximately 55 air miles east of Farmington, New Mexico, in Rio Arriba County within the Carson National Forest in the northeast portion of the San Juan Basin. Historically, Project Gasbuggy consisted of the joint government-industry detonation of a nuclear device on December 10, 1967, followed by reentry drilling and gas production testing and project evaluation activities in post-detonation operations from 1967 to 1976. Based on historical documentation, no chemical release sites other than the mud pits were identified; additionally, there was no material buried at the Gasbuggy Site other than drilling fluids and construction debris. Although previous characterization and restoration activities including sensitive species surveys, cultural resources surveys, surface geophysical surveys, and limited soil sampling and analysis were performed in 1978 and again in 2000, no formal closure of the site was achieved. Also, these efforts did not adequately address the site's potential for chemical contamination at the surface/shallow subsurface ground levels or the subsurface hazards for potential migration outside of the current site subsurface intrusion restrictions. Additional investigation

  19. 75 FR 64718 - Environmental Management Site-Specific Advisory Board, Nevada

    Science.gov (United States)

    2010-10-20

    ... Test Site including decontamination, closure, re-use and/or demolition. Purpose of the Soils Committee: The purpose of the Committee is to focus on issues related to soil contamination at the Nevada Test... Industrial Sites and Soils Committees of the Environmental Management Site-Specific Advisory Board (EM SSAB...

  20. A grammar inference approach for predicting kinase specific phosphorylation sites.

    Science.gov (United States)

    Datta, Sutapa; Mukhopadhyay, Subhasis

    2015-01-01

    Kinase mediated phosphorylation site detection is the key mechanism of post translational mechanism that plays an important role in regulating various cellular processes and phenotypes. Many diseases, like cancer are related with the signaling defects which are associated with protein phosphorylation. Characterizing the protein kinases and their substrates enhances our ability to understand the mechanism of protein phosphorylation and extends our knowledge of signaling network; thereby helping us to treat such diseases. Experimental methods for predicting phosphorylation sites are labour intensive and expensive. Also, manifold increase of protein sequences in the databanks over the years necessitates the improvement of high speed and accurate computational methods for predicting phosphorylation sites in protein sequences. Till date, a number of computational methods have been proposed by various researchers in predicting phosphorylation sites, but there remains much scope of improvement. In this communication, we present a simple and novel method based on Grammatical Inference (GI) approach to automate the prediction of kinase specific phosphorylation sites. In this regard, we have used a popular GI algorithm Alergia to infer Deterministic Stochastic Finite State Automata (DSFA) which equally represents the regular grammar corresponding to the phosphorylation sites. Extensive experiments on several datasets generated by us reveal that, our inferred grammar successfully predicts phosphorylation sites in a kinase specific manner. It performs significantly better when compared with the other existing phosphorylation site prediction methods. We have also compared our inferred DSFA with two other GI inference algorithms. The DSFA generated by our method performs superior which indicates that our method is robust and has a potential for predicting the phosphorylation sites in a kinase specific manner.

  1. A Grammar Inference Approach for Predicting Kinase Specific Phosphorylation Sites

    Science.gov (United States)

    Datta, Sutapa; Mukhopadhyay, Subhasis

    2015-01-01

    Kinase mediated phosphorylation site detection is the key mechanism of post translational mechanism that plays an important role in regulating various cellular processes and phenotypes. Many diseases, like cancer are related with the signaling defects which are associated with protein phosphorylation. Characterizing the protein kinases and their substrates enhances our ability to understand the mechanism of protein phosphorylation and extends our knowledge of signaling network; thereby helping us to treat such diseases. Experimental methods for predicting phosphorylation sites are labour intensive and expensive. Also, manifold increase of protein sequences in the databanks over the years necessitates the improvement of high speed and accurate computational methods for predicting phosphorylation sites in protein sequences. Till date, a number of computational methods have been proposed by various researchers in predicting phosphorylation sites, but there remains much scope of improvement. In this communication, we present a simple and novel method based on Grammatical Inference (GI) approach to automate the prediction of kinase specific phosphorylation sites. In this regard, we have used a popular GI algorithm Alergia to infer Deterministic Stochastic Finite State Automata (DSFA) which equally represents the regular grammar corresponding to the phosphorylation sites. Extensive experiments on several datasets generated by us reveal that, our inferred grammar successfully predicts phosphorylation sites in a kinase specific manner. It performs significantly better when compared with the other existing phosphorylation site prediction methods. We have also compared our inferred DSFA with two other GI inference algorithms. The DSFA generated by our method performs superior which indicates that our method is robust and has a potential for predicting the phosphorylation sites in a kinase specific manner. PMID:25886273

  2. Airborne remote sensors applied to engineering geology and civil works design investigations

    Science.gov (United States)

    Gelnett, R. H.

    1975-01-01

    The usefulness of various airborne remote sensing systems in the detection and identification of regional and specific geologic structural features that may affect the design and location of engineering structures on major civil works projects is evaluated. The Butler Valley Dam and Blue Lake Project in northern California was selected as a demonstration site. Findings derived from the interpretation of various kinds of imagery used are given.

  3. Temporally-controlled site-specific recombination in zebrafish.

    Directory of Open Access Journals (Sweden)

    Stefan Hans

    Full Text Available Conventional use of the site-specific recombinase Cre is a powerful technology in mouse, but almost absent in other vertebrate model organisms. In zebrafish, Cre-mediated recombination efficiency was previously very low. Here we show that using transposon-mediated transgenesis, Cre is in fact highly efficient in this organism. Furthermore, temporal control of recombination can be achieved by using the ligand-inducible CreER(T2. Site-specific recombination only occurs upon administration of the drug tamoxifen (TAM or its active metabolite, 4-hydroxy-tamoxifen (4-OHT. Cre-mediated recombination is detectable already 4 or 2 hours after administration of TAM or 4-OHT, demonstrating fast recombination kinetics. In addition, low doses of TAM allow mosaic labeling of single cells. Combined, our results show that conditional Cre/lox will be a valuable tool for both, embryonic and adult zebrafish studies. Furthermore, single copy insertion transgenesis of Cre/lox constructs suggest a strategy suitable also for other organisms.

  4. Work plan for the remedial investigation/feasibility study-environmental impact statement for the Weldon Spring site, Weldon Spring, Missouri

    International Nuclear Information System (INIS)

    Peterson, J.M.; MacDonell, M.M.; Haroun, L.A.; Nowadly, F.K.; Knight, W.C.; Vajda, G.F.

    1988-08-01

    The Weldon Spring Site Remedial Action Project is being conducted as a Major System Acquisition under the Surplus Facilities Management Program (SFMP) of the US Department of Energy (DOE). The major goals of the SFMP are to eliminate potential hazards to the public and the environment that are associated with contamination at SFMP sites and to make surplus real property available for other uses to the extent possible. The Weldon Spring site is located near Weldon Spring, Missouri, about 48 km (30 mi) west of St. Louis. It is surrounded by large tracts of land owned by the federal government and the state of Missouri. The site consists of four raffinate pits, an inactive chemical plant, and a contaminated quarry. The raffinate pits and chemical plant are on adjoining land about 3.2 km (2 mi) southwest of the junction of Missouri (State) Route 94 and US Route 40/61, with access from Route 94. The quarry is located in a comparatively remote area about 6.4 km (4 mi) south-southwest of the raffinate pits and chemical plant area; the quarry can also be accessed from Route 94. These areas are fenced and closed to the public. From 1941 to 1944, the US Department of the Army operated the Weldon Spring Ordnance Works, constructed on the land that is now the Weldon Spring site, for production of trinitrotoluene (TNT) and dinitrotoluene (DNT). The Army used the quarry for disposal of rubble contaminated with TNT. In the mid 1950s, 83 ha (205 acres) of the ordnance works property was transferred to the US Atomic Energy Commission (AEC); this is now the raffinate pits and chemical plant area. An additional 6 ha (15 acres) was later transferred to the AEC for expansion of waste storage capacity. 23 refs., 37 figs., 21 tabs

  5. Enhanced dimension-specific visual working memory in grapheme-color synesthesia.

    Science.gov (United States)

    Terhune, Devin Blair; Wudarczyk, Olga Anna; Kochuparampil, Priya; Cohen Kadosh, Roi

    2013-10-01

    There is emerging evidence that the encoding of visual information and the maintenance of this information in a temporarily accessible state in working memory rely on the same neural mechanisms. A consequence of this overlap is that atypical forms of perception should influence working memory. We examined this by investigating whether having grapheme-color synesthesia, a condition characterized by the involuntary experience of color photisms when reading or representing graphemes, would confer benefits on working memory. Two competing hypotheses propose that superior memory in synesthesia results from information being coded in two information channels (dual-coding) or from superior dimension-specific visual processing (enhanced processing). We discriminated between these hypotheses in three n-back experiments in which controls and synesthetes viewed inducer and non-inducer graphemes and maintained color or grapheme information in working memory. Synesthetes displayed superior color working memory than controls for both grapheme types, whereas the two groups did not differ in grapheme working memory. Further analyses excluded the possibilities of enhanced working memory among synesthetes being due to greater color discrimination, stimulus color familiarity, or bidirectionality. These results reveal enhanced dimension-specific visual working memory in this population and supply further evidence for a close relationship between sensory processing and the maintenance of sensory information in working memory. Copyright © 2013 The Authors. Published by Elsevier B.V. All rights reserved.

  6. Site systems engineering fiscal year 1999 multi-year work plan (MYWP) update for WBS 1.8.2.2; TOPICAL

    International Nuclear Information System (INIS)

    GRYGIEL, M.L.

    1998-01-01

    Manage the Site Systems Engineering process to provide a traceable integrated requirements-driven, and technically defensible baseline. Through the Site Integration Group(SIG), Systems Engineering ensures integration of technical activities across all site projects. Systems Engineering's primary interfaces are with the RL Project Managers, the Project Direction Office and with the Project Major Subcontractors, as well as with the Site Planning organization. Systems Implementation: (1) Develops, maintains, and controls the site integrated technical baseline, ensures the Systems Engineering interfaces between projects are documented, and maintain the Site Environmental Management Specification. (2) Develops and uses dynamic simulation models for verification of the baseline and analysis of alternatives. (3) Performs and documents fictional and requirements analyses. (4) Works with projects, technology management, and the SIG to identify and resolve technical issues. (5) Supports technical baseline information for the planning and budgeting of the Accelerated Cleanup Plan, Multi-Year Work Plans, Project Baseline Summaries as well as performance measure reporting. (6) Works with projects to ensure the quality of data in the technical baseline. (7) Develops, maintains and implements the site configuration management system

  7. Selective pressures to maintain attachment site specificity of integrative and conjugative elements.

    Directory of Open Access Journals (Sweden)

    Kayla L Menard

    Full Text Available Integrative and conjugative elements (ICEs are widespread mobile genetic elements that are usually found integrated in bacterial chromosomes. They are important agents of evolution and contribute to the acquisition of new traits, including antibiotic resistances. ICEs can excise from the chromosome and transfer to recipients by conjugation. Many ICEs are site-specific in that they integrate preferentially into a primary attachment site in the bacterial genome. Site-specific ICEs can also integrate into secondary locations, particularly if the primary site is absent. However, little is known about the consequences of integration of ICEs into alternative attachment sites or what drives the apparent maintenance and prevalence of the many ICEs that use a single attachment site. Using ICEBs1, a site-specific ICE from Bacillus subtilis that integrates into a tRNA gene, we found that integration into secondary sites was detrimental to both ICEBs1 and the host cell. Excision of ICEBs1 from secondary sites was impaired either partially or completely, limiting the spread of ICEBs1. Furthermore, induction of ICEBs1 gene expression caused a substantial drop in proliferation and cell viability within three hours. This drop was dependent on rolling circle replication of ICEBs1 that was unable to excise from the chromosome. Together, these detrimental effects provide selective pressure against the survival and dissemination of ICEs that have integrated into alternative sites and may explain the maintenance of site-specific integration for many ICEs.

  8. Management and Data Management Plan for Remedial Investigation at Fort George G. Meade Landfill and Preliminary Assessment/Site Investigation at the Former Gaithersburg NIKE Control and Launch Areas

    National Research Council Canada - National Science Library

    Edwards, D

    1989-01-01

    Work assignments under this contract will include a Preliminary Assessment/Site Investigation at the former Gaithersburg NIKE Control and Launch Areas and a Remedial Investigation at the Fort Meade...

  9. Potential energy center site investigations

    International Nuclear Information System (INIS)

    Savage, W.F.

    1977-01-01

    Past studies by the AEC, NRC, NSF and others have indicated that energy centers have certain advantages over dispersed siting. There is the need, however, to investigate such areas as possible weather modifications due to major heat releases, possible changes in Federal/state/local laws and institutional arrangements to facilitate implementation of energy centers, and to assess methods of easing social and economic pressures on a surrounding community due to center construction. All of these areas are under study by ERDA, but there remains the major requirement for the study of a potential site to yield a true assessment of the energy center concept. In this regard the Division of Nuclear Research and Applications of ERDA is supporting studies by the Southern and Western Interstate Nuclear Boards to establish state and utility interest in the concept and to carry out screening studies of possible sites. After selection of a final site for center study , an analysis will be made of the center including technical areas such as heat dissipation methods, water resource management, transmission methods, construction methods and schedules, co-located fuel cycle facilities, possible mix of reactor types, etc. Additionally, studies of safeguards, the interaction of all effected entities in the siting, construction, licensing and regulation of a center, labor force considerations in terms of local impact, social and economic changes, and financing of a center will be conducted. It is estimated that the potential site study will require approximately two years

  10. Investigations at the former sites of raw phosphate processing in Germany

    International Nuclear Information System (INIS)

    Reichelt, Andreas; Weiss, Dietmar; Feige, Sebastian; Wiegand, Jens; Gerler, Juergen

    2008-01-01

    Raw phosphates have been processed in an industrial scale in Germany approximately since the middle of the 19th century. During the centuries, huge amounts of residues with high mass specific activities have been accumulated. Within the framework of a historical study, we have determined the accumulated radionuclide inventory from 1865 to 2005. The consumption amounts to approx. 150 million tons raw phosphates (corresponds to approx. 2.22*10 14 Bq U-238) with a fraction of national production of approx. 1 million tons. A production of approx. 3 million tons of elemental phosphorus (calcium silicate slag: 3.6*10 13 Bq Ra-226) and approx. 12 million tons of phosphoric acid (phosphogypsum: 2.7*10 13 Bq Ra-226) had been achieved. In the next step, we have looked for the former sites with legacies of the raw phosphate processing industry. 92 sites of former production of phosphate fertilizers, 3 sites of former production of elemental phosphorus and 10 sites of former production of phosphoric acid had been identified. Some of them were selected for more detailed researches regarding the accumulated radionuclide inventory and on-site/laboratory radiological investigations. (author)

  11. Final work plan : investigation of potential contamination at the former USDA facility in Powhattan, Kansas.

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, L. M.; Environmental Science Division

    2007-02-02

    This Work Plan outlines the scope of work to be conducted to investigate the subsurface contaminant conditions at the property formerly leased by the Commodity Credit Corporation (CCC) in Powhattan, Kansas (Figure 1.1). Data obtained during this event will be used to (1) evaluate potential contaminant source areas on the property; (2) determine the vertical and horizontal extent of potential contamination; and (3) provide recommendations for future action, with the ultimate goal of assigning this site No Further Action status. The planned investigation includes groundwater monitoring requested by the Kansas Department of Health and Environment (KDHE), in accordance with Section V of the Intergovernmental Agreement between the KDHE and the Farm Service Agency of the U.S. Department of Agriculture (USDA). The work is being performed on behalf of the CCC/USDA by the Environmental Science Division of Argonne National Laboratory. A nonprofit, multidisciplinary research center operated by the University of Chicago for the U.S. Department of Energy, Argonne provides technical assistance to the CCC/USDA with environmental site characterization and remediation at former CCC/USDA grain storage facilities. Argonne issued a Master Work Plan (Argonne 2002) that has been approved by the KDHE. The Master Work Plan describes the general scope of all investigations at former CCC/USDA facilities in Kansas and provides guidance for these investigations. It should be consulted for the complete details of plans for work associated with the former CCC/USDA facility at Powhattan.

  12. Intermediary report on the 1994/95 investigations at the Wellenberg site (Community of Wolfenschiessen, NW)

    International Nuclear Information System (INIS)

    1996-01-01

    Following submission of the application for a general licence by GNW in June 1994, Nagra continued as planned with the field work at the Wellenberg site and with analysis of available data. In view of the delay in procedure brought about by the cantonal vote of 25th June 1995, the Federal Office of Energy requested GNW to review the geological content of the general license application in the light of more recent investigation results in order to give HSK (the Swiss Federal Nuclear Safety Inspectorate) access to the most up-to-date information when preparing its opinion. This is the purpose of the present report, which discusses the current status of ongoing analyses. The report concentrates on the main results only and is correspondingly concise; it is in no way intended to anticipate the final report on the Wellenberg investigations. The report begins by ountlining the aims of the site investigations of 1994/95 and goes on to discuss the field work performed at the site. The raw data available from the field investigations are also presented. The main section of the report discusses the first analyses of the data; these are then summarised into a set of geological conclusions which are complemented by a preliminary safety analysis. The resulting conceptualisations and parameter values clearly lie within the confines of the geological dataset used for the general licence application. It can therefore be concluded that the field investigations and complementary studies performed since the submission of the general licence application confirm the validity of the basic findings of the reference reports which formed the background to the application: the selected site is suitable for continuing investigations with a view to construction of a L/ILW repository. (author) figs., tabs., refs

  13. Site-specific dissociation dynamics of H2/D2 on Ag(111) and Co(0001) and the validity of the site-averaging model

    International Nuclear Information System (INIS)

    Hu, Xixi; Jiang, Bin; Xie, Daiqian; Guo, Hua

    2015-01-01

    Dissociative chemisorption of polyatomic molecules on metal surfaces involves high-dimensional dynamics, of which quantum mechanical treatments are computationally challenging. A promising reduced-dimensional approach approximates the full-dimensional dynamics by a weighted average of fixed-site results. To examine the performance of this site-averaging model, we investigate two distinct reactions, namely, hydrogen dissociation on Co(0001) and Ag(111), using accurate first principles potential energy surfaces (PESs). The former has a very low barrier of ∼0.05 eV while the latter is highly activated with a barrier of ∼1.15 eV. These two systems allow the investigation of not only site-specific dynamical behaviors but also the validity of the site-averaging model. It is found that the reactivity is not only controlled by the barrier height but also by the topography of the PES. Moreover, the agreement between the site-averaged and full-dimensional results is much better on Ag(111), though quantitative in neither system. Further quasi-classical trajectory calculations showed that the deviations can be attributed to dynamical steering effects, which are present in both reactions at all energies

  14. Optimization Under Uncertainty of Site-Specific Turbine Configurations

    Science.gov (United States)

    Quick, J.; Dykes, K.; Graf, P.; Zahle, F.

    2016-09-01

    Uncertainty affects many aspects of wind energy plant performance and cost. In this study, we explore opportunities for site-specific turbine configuration optimization that accounts for uncertainty in the wind resource. As a demonstration, a simple empirical model for wind plant cost of energy is used in an optimization under uncertainty to examine how different risk appetites affect the optimal selection of a turbine configuration for sites of different wind resource profiles. If there is unusually high uncertainty in the site wind resource, the optimal turbine configuration diverges from the deterministic case and a generally more conservative design is obtained with increasing risk aversion on the part of the designer.

  15. Predicting on-site environmental impacts of municipal engineering works

    OpenAIRE

    Gangolells Solanellas, Marta; Casals Casanova, Miquel; Forcada Matheu, Núria; Macarulla Martí, Marcel

    2014-01-01

    The research findings fill a gap in the body of knowledge by presenting an effective way to evaluate the significance of on-site environmental impacts of municipal engineering works prior to the construction stage. First, 42 on-site environmental impacts of municipal engineering works were identified by means of a process-oriented approach. Then, 46 indicators and their corresponding significance limits were determined on the basis of a statistical analysis of 25 new-build and remodelling mun...

  16. Hydrogeochemical site descriptive model - a strategy for the model development during site investigations

    International Nuclear Information System (INIS)

    Smellie, John; Laaksoharju, Marcus; Tullborg, Eva-Lena

    2002-12-01

    In 2002, SKB commenced site characterisation investigations using deep boreholes at different sites. As an integral part of the planning work SKB has prepared a strategy to develop a Hydrogeochemical Site Descriptive Model; similar strategies have been developed for the other major geoscience disciplines. The main objectives of the Hydrogeochemical Site Descriptive Model are to describe the chemistry and distribution of the groundwater in the bedrock and overburden and the hydrogeochemical processes involved in its origin and evolution. This description is based primarily on measurements of the groundwater composition but incorporates the use of available geological and hydrogeological site descriptive models. The SKB hydrogeochemistry programme is planned to fulfil two basic requirements: 1) to provide representative and quality assured data for use as input parameter values in calculating long-term repository safety, and 2) to understand the present undisturbed hydrogeochemical conditions and how these conditions will change in the future. Parameter values for safety analysis include pH, Eh, S, SO 4 , HCO 3 , HPO 4 and TDS (mainly cations), together with colloids, fulvic and humic acids, other organics, bacteria and nitrogen. These values will be used to characterise the groundwater environment at, above and below repository depths. In the hydrogeochemical site investigation programme the number and location of the sampling points will be constrained by: a) geology (e.g. topography, overburden types, bedrock structures etc), b) hydrogeology (e.g. groundwater recharge/discharge areas, residence times), c) reliability (e.g. undisturbed vs disturbed groundwater chemical conditions), and d) resources (e.g. number and type of samples, and also available personnel, may be restricted by budgetary and schedule concerns). Naturally a balance is required between these constraints and the scientific aims of the programme. The constraints should never detrimentally affect

  17. Site preparation and excavation works for the foundation of station main building among construction works for No. 1 unit in Kashiwazaki-Kariwa Nuclear Pwer Station

    International Nuclear Information System (INIS)

    Ueyama, Koreyasu

    1982-01-01

    Tokyo Electric Power Co., Inc., is planning the nuclear power station of final capacity 8,000 MW (7 units) in the region spread over Kashiwazaki City and Kariwa Village in Niigata Prefecture. For No. 1 unit (1100 MWe BWR), the reactor installation license was obtained in September, 1977, the site preparation and road construction started in April, 1978, and harbour construction works started in August, 1979. The construction works are now at the peak, and the overall progressing rate as of the end of June, 1982, is about 51 %. The site is a hilly region of dune along the coast of the Sea of Japan, and No. 1 unit is located in the southern part of the site. This paper reports on the outline of the project, site preparation and excavation works for the foundation of the station main building. For the site preparation and the excavation works for the foundation the main building, the shape of slope cutting, the design of landslide-preventing wall for the vertical excavation for the reactor complex building, and the construction plan and the result are reported. For underground water impermeable wall works, its outline, groundwater condition, groundwater simulation analysis, the investigation of wall installation, the wall structure and construction are described in detail. Also the outline of the control of slope face measurement, the control standards and the measured results are reported. (Wakatsuki, Y.)

  18. Site preparation and excavation works for the foundation of station main building among construction works for No. 1 unit in Kashiwazaki-Kariwa Nuclear Power Station

    Energy Technology Data Exchange (ETDEWEB)

    Ueyama, Koreyasu [Tokyo Electric Power Co., Inc. (Japan)

    1982-09-01

    Tokyo Electric Power Co., Inc., is planning the nuclear power station of final capacity 8,000 MW (7 units) in the region spread over Kashiwazaki City and Kariwa Village in Niigata Prefecture. For No. 1 unit (1100 MWe BWR), the reactor installation license was obtained in September, 1977, the site preparation and road construction started in April, 1978, and harbour construction works started in August, 1979. The construction works are now at the peak, and the overall progressing rate as of the end of June, 1982, is about 51 %. The site is a hilly region of dune along the coast of the Sea of Japan, and No. 1 unit is located in the southern part of the site. This paper reports on the outline of the project, site preparation and excavation works for the foundation of the station main building. For the site preparation and the excavation works for the foundation the main building, the shape of slope cutting, the design of landslide-preventing wall for the vertical excavation for the reactor complex building, and the construction plan and the result are reported. For underground water impermeable wall works, its outline, groundwater condition, groundwater simulation analysis, the investigation of wall installation, the wall structure and construction are described in detail. Also the outline of the control of slope face measurement, the control standards and the measured results are reported.

  19. Development of site specific response spectra

    International Nuclear Information System (INIS)

    Bernreuter, D.L.; Chen, J.C.; Savy, J.B.

    1987-03-01

    For a number of years the US Nuclear Regulatory Commission (NRC) has employed site specific spectra (SSSP) in their evaluation of the adequacy of the Safe Shutdown Earthquake (SSE). These spectra were developed only from the spectra of the horizontal components of the ground motion and from a very limited data set. As the data set has considerably increased for Eastern North America (ENA) and as more relevant data has become available from earthquakes occurring in other parts of the world (e.g., Italy), together with the fact that recent data indicated the importance of the vertical component, it became clear that an update of the SSSP's for ENA was desirable. The methodology used in this study is similar to the previous ones in that it used actual earthquake ground motion data with magnitudes within a certain range and recorded at distances and at sites similar to those that would be chosen for the definition of an SSE. An extensive analysis of the origin and size of the uncertainty is an important part of this study. The results of this analysis of the uncertainties is used to develop criteria for selecting the earthquake records to be used in the derivation of the SSSP's. We concluded that the SSSPs were not very sensitive to the distribution of the source to site distance of the earthquake records used in the analysis. That is, the variability (uncertainty) introduced by the range of distances was relatively small compared to the variability introduced by other factors. We also concluded that the SSSP are somewhat sensitive to the distribution of the magnitudes of these earthquakes, particularly at rock sites and, by inference, at shallow soil sites. We found that one important criterion in selecting records to generate SSSP is the depth of soil at the site

  20. DOE's Environmental Management Site-Specific Advisory Board: The Roles, Work, and Assessment of the Constituent Local Boards - 13587

    Energy Technology Data Exchange (ETDEWEB)

    Alexander, Catherine [U.S. Dept. of Energy, Office of Environmental Management, Office of Intergovernmental and Community Activities, 1000 Independence Avenue, S.W.,Washington, D.C. 20585 (United States); Freeman, Jenny [Strata-G, LLC, 2027 Castaic Lane, Knoxville, TN 37932 (United States); Cantrell, Yvette [Restoration Services, Inc., 136 Mitchell Road, Oak Ridge, TN 37830 (United States)

    2013-07-01

    The charter for the Department of Energy's Environmental Management (EM) Site-Specific Advisory Board (SSAB) was approved under the Federal Advisory Committee Act (FACA) in 1994. With a unique mandate to provide public input on issues associated with the cleanup of nuclear legacy sites in the U.S., the EM SSAB comprises eight local boards, which are based at major EM sites. While each board is unique to the community in which it is located and reflects the diversity of the local population, the boards are governed by FACA, related regulations, and DOE policies that are intended to standardize agency advisory board operations. The EM SSAB local boards are made up of a diverse group of citizens who want to understand the mission and goals of the EM program and to help EM achieve those goals for the benefit of their communities. Some are quite passionate about their mission; others need to be coaxed into active participation. Maintaining productive relationships and a supportive environment for effective board operations is the challenge of board management for DOE EM and the board members themselves. DOE draws on research findings and best practices literature from academics and practitioners in the field of public involvement in its board management practices. The EM SSAB is also evaluated annually under the law to ensure that the investment of taxpayer dollars in the board is warranted in light of the contributions of the board. Further evaluation takes place at the agency and site levels in order to identify what aspects of board functioning the agency and board members find important to its success and to address areas where improvement is needed. Board contributions, compliance factors, and measurable outcomes related to board products and process areas are key to agency commitment to ongoing support of the boards and to participant satisfaction and thus continued member involvement. In addition to evaluation of these factors in improving board

  1. Optimization of compaction specifications for different pavements layers

    CSIR Research Space (South Africa)

    Semmelink, CJ

    1994-03-01

    Full Text Available The report deals with the site investigations in connection with the compaction standards, that is a comparison between actual in situ dry densities achieved compared to specification requirements, for road layer work for the periods 91/92, 92...

  2. Site Characterization Work Plan for the Gnome-Coach Site, New Mexico (Rev. 1, January 2002); FINAL

    International Nuclear Information System (INIS)

    2002-01-01

    Project Gnome was the first nuclear experiment conducted under the U.S. Atomic Energy Commission (AEC), predecessor to the U.S. Department of Energy (DOE), Plowshare Program. The Plowshare Program focused on developing nuclear devices exclusively for peaceful purposes. The intent of the Gnome experiment was to evaluate the effects of a nuclear detonation in a salt medium. Historically, Project Gnome consisted of a single detonation of a nuclear device on December 10, 1961 with the Salado Formation. Since the Gnome detonation, the AEC/DOE has conducted surface restoration, site reconnaissance, and decontamination and decommissioning activities at the site. In addition, annual groundwater sampling is performed under a long-term hydrological monitoring program begun in 1972. Coach, an experiment to be located near the Gnome project, was initially scheduled for 1963. Although construction and rehabilitation were completed for Coach, the experiment was canceled and never executed. Known collectively as Project Gnome-Coach, the site is located approximately 25 miles east of Carlsbad, New Mexico, in Eddy County, and is comprised of nearly 680 acres, of which approximately 60 acres are disturbed from the combined AEC/DOE operations. The scope of this work plan is to document the environmental objectives and the proposed technical site investigation strategies that will be utilized for the site characterization of the project. The subsurface at the Gnome-Coach site has two contaminant sources that are fundamentally different in terms of both their stratigraphic location and release mechanism. The goal of this characterization is to collect data of sufficient quantity and quality to establish current site conditions and to use the data to identify and evaluate if further action is required to protect human health and the environment and achieve permanent closure of the site. The results of these activities will be presented in a subsequent corrective action decision document

  3. Understanding pathways of exposure using site-specific habits surveys, particularly new pathways and methodologies

    International Nuclear Information System (INIS)

    Grzechnik, M.; McTaggart, K.; Clyne, F.

    2006-01-01

    Full text of publication follows: UK policy on the control of radiation exposure via routine discharges from nuclear licensed sites has long been based on ICRP recommendations that embody the principles of justification of practices, optimisation of protection, and dose limitation. Radiological protection of the public is based on the concept of a critical group of individuals. This group is defined as those people who, as a result of the area they reside and their habits, receive the highest radiation dose due to the operations of a site. Therefore, if the dose to this critical group is acceptable in relation to relevant dose limits and constraints, then other members of the public will receive lower doses. Thus, the principle of critical groups provides overall protection for the public. Surveys to determine local habits involve an integrated methodology, whereby the potential radioactive exposure pathways from liquid and gaseous discharges and direct radiation from the site are investigated. Surveys to identify these habits must be undertaken rigorously for consistency, and have been known to reveal unexpected pathways of radiation exposure. Pathways typically include consumption of local foodstuffs and external exposure. Furthermore, a number of critical groups ma y be identified within a single survey area if the habits of one group do not adequately describe those of the other inhabitants of the area. Survey preparation involves the initial identification of high producers and consumers of local foods in a geographically defined area surrounding the nuclear facility. Pathways can be broken down into three general groups, which include exposure arising from; 1) Terrestrial (gaseous) discharges surveyed within 5 km of the site 2) Direct radiation surveyed within 1 km of the site 3) Aquatic (liquid) discharges surveyed within local areas affected by the discharges, including seas, rivers and sewage works. The survey fieldwork involves interviewing members of the

  4. Hanford site past practice investigation strategy: Lessons learned

    International Nuclear Information System (INIS)

    Thompson, K. Michael

    1992-01-01

    The U. S. Department of Energy (DOE), U. S. Environmental Protection Agency (EPA), and the Washington State Department of Ecology (Ecology) have negotiated a strategy for performing Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) and Resource Conservation and Recovery Act (RCRA) Past Practice investigations in a more streamlined manner with a bias-for-action. This strategy provides new concepts for 1) accelerating decision-making by maximizing the use of existing data consistent with data quality objectives and 2) undertaking expedited response actions and/or interim remedial measures as appropriate to either remove threats to human health and welfare and the environment or to reduce risk by reducing toxicity, mobility or volume of contaminants. Since the goal of the program is cleanup, much more emphasis will be placed on initiating and completing waste site cleanups through interim measures. While investigations and studies are important in meeting long-range goals, there is now agreement by the parties that an appropriate and significant portion of the near-term funding resources can and should be dedicated to remedial work, where there is sufficient information from which to plan and implement interim remedial measures. The initial stages of Hanford clean-up will optimize the use of interim cleanup actions when justified and practicable. Existing data will be evaluated as the initial basis for decision-making. If the data are found to be insufficient, additional essential data will be collected to support the IRM in a limited field investigation (LFI). Only data needed to formulate a conceptual model (source to pathway to receptor) and qualitative risk assessment would be obtained. The data quality objectives of the LFI will be established based on the use of the data in deciding on IRMs. The data might not need to be of the same quality needed to support final RODs, since the IRM itself would yield valuable information for

  5. Work management administration FY 1995 site support program plan WBS 6.2

    Energy Technology Data Exchange (ETDEWEB)

    Hale, N.S.

    1994-09-01

    Westinghouse Hanford Company`s (WHC) near-term vision is to implement a Site-wide work management program that is consistent from one facility to the other, and can realize workforce efficiencies, minimum down time, and familiarization with facilities uniqueness. Additionally, consistent Hanford Site work management processes can produce meaningful information to be shared complex-wide as the US Department of Energy (DOE) cleans up facilities Site-wide. It is the mission of the WHC Work Management Administration Program to provide guidance and program direction on how to implement consistent and effective work management across the Hanford Site that comply with the DOE and other regulatory requirements. This report describes the steps needed to implement a work management plan at Hanford.

  6. The Lusi eruption site: insights from surface and subsurface investigations

    Science.gov (United States)

    Mazzini, A.

    2017-12-01

    The Indonesian Lusi eruption has been spewing boiling water, gas, and sediments since the 29th of May 2006. Initially, numerous aligned eruptions sites appeared along the Watukosek fault system (WFS) that was reactivated after the Yogyakarta earthquake occurring the 27th of May in the Java Island. Within weeks several villages were submerged by boiling mud. The most prominent eruption site was named Lusi. To date Lusi is still active and an area of 7 km2is covered by mud. Since its birth Lusi erupted with a pulsating behaviour. In the framework of the ERC grant "Lusi Lab" we conducted several years of monitoring and regional investigations coupling surface sampling and subsurface imaging in the region around Lusi. Ambient noise tomography studies, obtained with a local network of 31 stations, revealed for the first time subsurface images of the Lusi region and the adjacent Arjuno-Welirang (AW) volcanic complex. Results show that below the AW volcanic complex are present 5km deep magma chambers that are connected, through a defined corridor, with the roots of the Lusi eruption site. The Lusi subsurface shows the presence of a defined vertical hydrothermal plume that extends to at least 5km. Chemical analyses of the seeping fluids sampled from 1) the Lusi plume (using a specifically designed drone), 2) the region around Lusi, and 3) the fumaroles and the hydro thermal springs of AW, revealed striking similarities. More specifically a mantellic signature of the Lusi fluids confirms the scenario that Lusi represents a magmatic-driven hydrothermal system hosted in sedimentary basin. Seismic profiles interpretation, surface mapping, and fluid sampling show that the WFS, connecting AW and extending towards the NE of Java, acted as a preferential pathway for the igneous intrusion and fluids migration towards the subsurface. Petrography and dating of the clasts erupted at Lusi record high temperatures and indicate that the roots of the active conduit extend to at least 5km

  7. 29 CFR 785.12 - Work performed away from the premises or job site.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Work performed away from the premises or job site. 785.12... of Principles Employees âsuffered Or Permittedâ to Work § 785.12 Work performed away from the premises or job site. The rule is also applicable to work performed away from the premises or the job site...

  8. Corrective Action Investigation Plan for Corrective Action Unit 570: Area 9 Yucca Flat Atmospheric Test Sites Nevada National Security Site, Nevada, Revision 0

    Energy Technology Data Exchange (ETDEWEB)

    Patrick Matthews

    2012-08-01

    CAU 570 comprises the following six corrective action sites (CASs): • 02-23-07, Atmospheric Test Site - Tesla • 09-23-10, Atmospheric Test Site T-9 • 09-23-11, Atmospheric Test Site S-9G • 09-23-14, Atmospheric Test Site - Rushmore • 09-23-15, Eagle Contamination Area • 09-99-01, Atmospheric Test Site B-9A These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives (CAAs). Additional information will be obtained by conducting a corrective action investigation before evaluating CAAs and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable CAAs that will be presented in the Corrective Action Decision Document. The sites will be investigated based on the data quality objectives (DQOs) developed on April 30, 2012, by representatives of the Nevada Division of Environmental Protection and the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 570. The site investigation process will also be conducted in accordance with the Soils Activity Quality Assurance Plan, which establishes requirements, technical planning, and general quality practices to be applied to this activity. The presence and nature of contamination at CAU 570 will be evaluated based on information collected from a field investigation. Radiological contamination will be evaluated based on a comparison of the total effective dose at sample locations to the dose-based final action level. The total effective dose will be calculated as the total of separate estimates of internal and external dose. Results from the analysis of soil samples will be used to calculate internal radiological

  9. Guideline for environmental site investigations in Manitoba : June 1998

    International Nuclear Information System (INIS)

    1998-06-01

    The procedures for the investigation and characterization of contaminated sites in Manitoba are described in an effort to provide a baseline for developing applicable risk-based remedial action and management plans. This document presents information regarding the methods and protocols for sites where the quality of groundwater, surface water, sediments or soil may have been affected by pollutants as a result of past or present usage of the site. The 1998 document focuses on petroleum impacted sites and also includes the requirements for the investigation of sites potentially impacted by other pollutants. It is based on the principles established by the Canadian Council of Ministers of the Environment for the management of sites in Canada and the requirements of the Manitoba Contaminated Sites Remediation and Consequential Amendments Act. Manitoba's petroleum storage program and the hazardous waste management program, including the disposal or treatment of contaminated soils are also summarized

  10. Taxon- and Site-Specific Melatonin Catabolism

    Directory of Open Access Journals (Sweden)

    Rüdiger Hardeland

    2017-11-01

    Full Text Available Melatonin is catabolized both enzymatically and nonenzymatically. Nonenzymatic processes mediated by free radicals, singlet oxygen, other reactive intermediates such as HOCl and peroxynitrite, or pseudoenzymatic mechanisms are not species- or tissue-specific, but vary considerably in their extent. Higher rates of nonenzymatic melatonin metabolism can be expected upon UV exposure, e.g., in plants and in the human skin. Additionally, melatonin is more strongly nonenzymatically degraded at sites of inflammation. Typical products are several hydroxylated derivatives of melatonin and N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK. Most of these products are also formed by enzymatic catalysis. Considerable taxon- and site-specific differences are observed in the main enzymatic routes of catabolism. Formation of 6-hydroxymelatonin by cytochrome P450 subforms are prevailing in vertebrates, predominantly in the liver, but also in the brain. In pineal gland and non-mammalian retina, deacetylation to 5-methoxytryptamine (5-MT plays a certain role. This pathway is quantitatively prevalent in dinoflagellates, in which 5-MT induces cyst formation and is further converted to 5-methoxyindole-3-acetic acid, an end product released to the water. In plants, the major route is catalyzed by melatonin 2-hydroxylase, whose product is tautomerized to 3-acetamidoethyl-3-hydroxy-5-methoxyindolin-2-one (AMIO, which exceeds the levels of melatonin. Formation and properties of various secondary products are discussed.

  11. Getting ready for inspection of investigational site at short notice

    Directory of Open Access Journals (Sweden)

    Rajendra Talele

    2010-01-01

    Full Text Available India is becoming an attractive destination for drug development and clinical research. This is evidenced by the three fold increment in clinical trial applications in last four years to the office of Drugs Controller General of India (DCGI. This upward trend is collaborative efforts of all stake holders and the quality of Indian data. Therefore to sustain this trend, it is important that stake holders such as Regulators, Sponsor, CRO, Monitor, Investigators and trial subjects required maintaining high standards of data and conduct of clinical trials. Indian regulations and the role of DCGI in quality check for Indian clinical trials is always a topic of discussion in various forums. A recent move by DCGI for conducting random inspections of investigational sites and companies at short notice, checking their compliance in accordance with the guidelines, and taking action against non-complier is welcomed. This will certainly increase over quality of the clinical trials. Quality of clinical trial conduct is measured on essential documents for their appropriateness and its correctness. It is observed that the stakeholders engaged in multitasking often overlook the requirements or appropriateness of the document due to their focused approach on a specific activity which is on priority. This can lead to serious quality problem and issues. Understanding of the process and documents reviewed by auditor is important to maintain such high quality. The proper planning and time management working on essential documents can minimize the quality issues, and we can be always ready for any type of inspection, announced or unannounced, or "short notice".

  12. Sectored Clean-up Work Plan for Housekeeping Category Waste Sites

    International Nuclear Information System (INIS)

    Nacht, S. J.

    2000-01-01

    The Sectored Clean-up Work Plan (SCWP) replaces the Housekeeping Category Corrective Action Unit Work Plan and provides a strategy to be used for conducting housekeeping activities using a sectored clean-up approach. This work plan provides a process by which one or more existing housekeeping category Corrective Action Sites (CASS) from the Federal Facility Agreement and Consent Order and/or non-FFACO designated waste site(s) are grouped into a sector for simultaneous remediation and cleanup. This increases effectiveness and efficiencies in labor, materials, equipment, cost, and time. This plan is an effort by the U.S. Department of Energy to expedite work in a more organized and efficient approach. The objectives of this plan are to: Group housekeeping FFACO CASS and non-FFACO housekeeping sites into sectors and remediate during the same field visit; Provide consistent documentation on FFACO CAS and non-FFACO clean-up activities; Perform similar activities under one approved document; Remediate areas inside the Deactivation and Decommissioning facilities and compounds in a campaign-style remediation; and Increase efficiencies and cost-effectiveness, accelerate cleanups, reduce mobilization, demobilization, and remediation costs

  13. Site-specific RNase A activity was dramatically reduced in serum from multiple types of cancer patients.

    Directory of Open Access Journals (Sweden)

    Weiyan Huang

    Full Text Available Potent RNase activities were found in the serum of mammals but the physiological function of the RNases was never well illustrated, largely due to the caveats in methods of RNase activity measurement. None of the existing methods can distinguish between RNases with different target specificities. A systematic study was recently carried out in our lab to investigate the site-specificity of serum RNases on double-stranded RNA substrates, and found that serum RNases cleave double-stranded RNAs predominantly at 5'-U/A-3' and 5'-C/A-3' dinucleotide sites, in a manner closely resembling RNase A. Based on this finding, a FRET assay was developed in the current study to measure this site-specific serum RNase activity in human samples using a double stranded RNA substrate. We demonstrated that the method has a dynamic range of 10(-5 mg/ml- 10(-1 mg/ml using serial dilution of RNase A. The sera of 303 cancer patients were subjected to comparison with 128 healthy controls, and it was found that serum RNase activities visualized with this site-specific double stranded probe were found to be significantly reduced in patients with gastric cancer, liver cancer, pancreatic cancer, esophageal cancer, ovary cancer, cervical cancer, bladder cancer, kidney cancer and lung cancer, while only minor changes were found in breast and colon cancer patients. This is the first report using double stranded RNA as probe to quantify site-specific activities of RNase A in a serum. The results illustrated that RNase A might be further evaluated to determine if it can serve as a new class of biomarkers for certain cancer types.

  14. Site-Specific RNase A Activity Was Dramatically Reduced in Serum from Multiple Types of Cancer Patients

    Science.gov (United States)

    Huang, Weiyan; Zhao, Mei; Wei, Na; Wang, Xiaoxia; Cao, Huqing; Du, Quan; Liang, Zicai

    2014-01-01

    Potent RNase activities were found in the serum of mammals but the physiological function of the RNases was never well illustrated, largely due to the caveats in methods of RNase activity measurement. None of the existing methods can distinguish between RNases with different target specificities. A systematic study was recently carried out in our lab to investigate the site-specificity of serum RNases on double-stranded RNA substrates, and found that serum RNases cleave double-stranded RNAs predominantly at 5′-U/A-3′ and 5′-C/A-3′ dinucleotide sites, in a manner closely resembling RNase A. Based on this finding, a FRET assay was developed in the current study to measure this site-specific serum RNase activity in human samples using a double stranded RNA substrate. We demonstrated that the method has a dynamic range of 10−5 mg/ml- 10−1 mg/ml using serial dilution of RNase A. The sera of 303 cancer patients were subjected to comparison with 128 healthy controls, and it was found that serum RNase activities visualized with this site-specific double stranded probe were found to be significantly reduced in patients with gastric cancer, liver cancer, pancreatic cancer, esophageal cancer, ovary cancer, cervical cancer, bladder cancer, kidney cancer and lung cancer, while only minor changes were found in breast and colon cancer patients. This is the first report using double stranded RNA as probe to quantify site-specific activities of RNase A in a serum. The results illustrated that RNase A might be further evaluated to determine if it can serve as a new class of biomarkers for certain cancer types. PMID:24805924

  15. Seismic and geologic investigations of the Sandia Livermore Laboratory site

    International Nuclear Information System (INIS)

    Anon.

    1978-01-01

    This report describes results of a seismic and geologic investigation in the vicinity of Sandia Laboratories property and Sandia's Tritium Building at Livermore, California. The investigation was done to define any seismically capable faults in the immediate area and to obtain necessary information to support estimates of future possible or probable ground motions. The work included a variety of geophysical measurements, trenching, seismologic studies, geologic examination, and evaluation of possible ground surface rupture at the site. Ground motions due to the maximum potential earthquake are estimated, and probability of exceedance for various levels of peak ground acceleration is calculated. Descriptions of the various calculations and investigative techniques used and the data obtained are presented. Information obtained from other sources relevant to subsurface geology and faulting is also given. Correlation and evaluation of the various lines of evidence and conclusions regarding the seismic hazard to the Tritium Building are included

  16. Conversion of MyoD to a Neurogenic Factor: Binding Site Specificity Determines Lineage

    Directory of Open Access Journals (Sweden)

    Abraham P. Fong

    2015-03-01

    Full Text Available MyoD and NeuroD2, master regulators of myogenesis and neurogenesis, bind to a “shared” E-box sequence (CAGCTG and a “private” sequence (CAGGTG or CAGATG, respectively. To determine whether private-site recognition is sufficient to confer lineage specification, we generated a MyoD mutant with the DNA-binding specificity of NeuroD2. This chimeric mutant gained binding to NeuroD2 private sites but maintained binding to a subset of MyoD-specific sites, activating part of both the muscle and neuronal programs. Sequence analysis revealed an enrichment for PBX/MEIS motifs at the subset of MyoD-specific sites bound by the chimera, and point mutations that prevent MyoD interaction with PBX/MEIS converted the chimera to a pure neurogenic factor. Therefore, redirecting MyoD binding from MyoD private sites to NeuroD2 private sites, despite preserved binding to the MyoD/NeuroD2 shared sites, is sufficient to change MyoD from a master regulator of myogenesis to a master regulator of neurogenesis.

  17. Development of the NUMO pre-selection, site-specific safety case

    International Nuclear Information System (INIS)

    Fujiyama, Tetsuo; Suzuki, Satoru; Deguchi, Akira; Umeki, Hiroyuki

    2016-01-01

    Key conclusions: ◆ “The NUMO pre-selection, site-specific safety case” provides the basic structure for subsequent safety cases that will be applied to any selected site, emphasising practical approaches and methodology which will be applicable for the conditions/constraints during an actual siting process. ◆ The preliminary results of the design and safety assessment would underpin the feasibility and safety of geological disposal in Japan.

  18. Corrective Action Investigation Plan for Corrective Action Unit 104: Area 7 Yucca Flat Atmospheric Test Sites, Nevada National Security Site, Nevada, Revision 0

    Energy Technology Data Exchange (ETDEWEB)

    Patrick Matthews

    2011-08-01

    of the total effective dose (TED) to the dose-based final action level (FAL). The presence of TED exceeding the FAL is considered a radiological contaminant of concern (COC). Anything identified as a COC will require corrective action. The TED will be calculated as the total of separate estimates of internal and external dose. Results from the analysis of soil samples will be used to calculate internal radiological dose. Thermoluminescent dosimeters will be used to measure external radiological dose. Based on process knowledge of the releases associated with the nuclear tests and radiological survey information about the location and shape of the resulting contamination plume, it was determined that the releases from the nuclear tests are co-located and will be investigated concurrently. A field investigation will be performed to define areas where TED exceeds the FAL and to determine whether other COCs are present at the site. The investigation will also collect information to determine the presence and nature of contamination associated with migration and excavation, as well as any potential releases discovered during the investigation. Appendix A provides a detailed discussion of the DQO methodology and the DQOs specific to each CAS.

  19. Integration of a working site in its regional context

    International Nuclear Information System (INIS)

    Couture, J.

    1986-01-01

    This paper shows how a local representative has felt the decision of construction of the Paluel nuclear power plant and the problems involved, and how it has been tried to resolve them: insertion in the site, reception of the population of this big working site [fr

  20. Mirth and Murder: Crime Scene Investigation as a Work Context for Examining Humor Applications

    Science.gov (United States)

    Roth, Gene L.; Vivona, Brian

    2010-01-01

    Within work settings, humor is used by workers for a wide variety of purposes. This study examines humor applications of a specific type of worker in a unique work context: crime scene investigation. Crime scene investigators examine death and its details. Members of crime scene units observe death much more frequently than other police officers…

  1. Waste site grouping for 200 Areas soil investigations

    International Nuclear Information System (INIS)

    1997-01-01

    The purpose of this document is to identify logical waste site groups for characterization based on criteria established in the 200 Areas Soil Remediation Strategy (DOE-RL 1996a). Specific objectives of the document include the following: finalize waste site groups based on the approach and preliminary groupings identified in the 200 Areas Soil Remediation Strategy; prioritize the waste site groups based on criteria developed in the 200 Areas Soil Remediation Strategy; select representative site(s) that best represents typical and worse-case conditions for each waste group; develop conceptual models for each waste group. This document will serve as a technical baseline for implementing the 200 Areas Soil Remediation Strategy. The intent of the document is to provide a framework, based on waste site groups, for organizing soil characterization efforts in the 200 Areas and to present initial conceptual models

  2. Annotated Administrative Record Site-Specific Document Index, American Drum & Pallet Co. Removal Site, Memphis, Shelby County, Tennessee

    Science.gov (United States)

    Contains annotated index of site specific documents for the American Drum & Pallet Co. Removal Site in Memphis, Shelby County, Tennessee, January 9, 2008 Region ID: 04 DocID: 10517016, DocDate: 01-09-2008

  3. Planning for investigation and evaluation of potential repository sites in Sweden

    International Nuclear Information System (INIS)

    Almen, K.E.; Stroem, A.

    1998-01-01

    The present stage of siting of the Swedish Deep Repository for spent nuclear fuel involves general siting studies on national and regional scales and feasibility studies on a municipal scale. Based on these studies, two areas will be selected for surface-based site investigations. The geoscientific site information will be used in the site evaluation process, in which performance and safety assessments and design studies are the major activities, in combination with geoscientific characterization. The safety report and EIA document from the site investigation stage will be the most important documents in the application for the siting permit and the permit to construct the deep repository. Detailed characterization will then verify the suitability of the selected site. The programme for geoscientific site investigations is based on experience from more than 20 years of field studies in several SKB projects, such as the Study Site Investigations , the Stripa Project, and the Aespoe Hard Rock Laboratory. The strategies and methodologies developed, implemented and verified within the Aespoe HRL are a very important source of information and know-how for the development of the site investigation programme. The investigations will produce geoscientific models that include all information needed to analyze the long-term safety of a deep repository located in and adapted to the geological conditions of the rock. The type of geoscientific information needed for performance and safety assessment, layout and design, environmental studies and for fundamental geoscientific understanding has been specified and compiled in a 'parameter' report. The general strategy is that performance assessment, layout and design studies will be conducted in parallel with the geoscientific investigations. Information will be transferred at logical occasions, when decisions have to be taken and when feedback is desirable for new investigation steps. The role of the geoscientific evaluation is to

  4. Final master work plan : environmental investigations at former CCC/USDA facilities in Kansas, 2002 revision.

    Energy Technology Data Exchange (ETDEWEB)

    Burton, J. C.; Environmental Research

    2003-01-23

    mistake sometimes made in the site characterization process is failure to use technically sound available data to form working hypotheses on hydrogeology, contaminant distribution, etc. for initial testing. (3) After assembling and interpreting existing data for the site, the entire technical team visits the site to identify as a group the site characteristics that might prohibit or enhance any particular technological approach. Logistic and community constraints are also identified at this point. (4) After the field visit, the team selects a suite of technologies appropriate to the problem and completes the design of the field program. No one technique works well at all sites, and a suite of techniques is necessary to delineate site features fully. In addition, multiple technologies are employed to increase confidence in conclusions about site features. Noninvasive and minimally invasive technologies are emphasized to minimize risk to the environment, the community, and the staff. In no case is the traditional approach of installing a massive number of monitoring wells followed. A dynamic work plan that outlines the program is produced for the sponsoring and regulatory agencies. The word ''dynamic'' is emphasized because the work plan is viewed as a guide, subject to modification, for the site characterization activity, rather than a document that is absolute and unchangeable. Therefore, the health and safety plan and the quality assurance/quality control plan must be broad and encompass all possible alterations to the plan. The cooperation of the regulating agency is essential in successful implementation of this process. The sponsoring and regulatory agencies are notified if significant changes to the site-specific work plan are necessary. (5) The entire team participates in the technical field program. Several technical activities are undertaken simultaneously. These may range from different surface geophysics investigations to vegetation sampling

  5. Site-specific fab fragment biotinylation at the conserved nucleotide binding site for enhanced Ebola detection.

    Science.gov (United States)

    Mustafaoglu, Nur; Alves, Nathan J; Bilgicer, Basar

    2015-07-01

    The nucleotide binding site (NBS) is a highly conserved region between the variable light and heavy chains at the Fab domains of all antibodies, and a small molecule that we identified, indole-3-butyric acid (IBA), binds specifically to this site. Fab fragment, with its small size and simple production methods compared to intact antibody, is good candidate for use in miniaturized diagnostic devices and targeted therapeutic applications. However, commonly used modification techniques are not well suited for Fab fragments as they are often more delicate than intact antibodies. Fab fragments are of particular interest for sensor surface functionalization but immobilization results in damage to the antigen binding site and greatly reduced activity due to their truncated size that allows only a small area that can bind to surfaces without impeding antigen binding. In this study, we describe an NBS-UV photocrosslinking functionalization method (UV-NBS(Biotin) in which a Fab fragment is site-specifically biotinylated with an IBA-EG11-Biotin linker via UV energy exposure (1 J/cm(2)) without affecting its antigen binding activity. This study demonstrates successful immobilization of biotinylated Ebola detecting Fab fragment (KZ52 Fab fragment) via the UV-NBS(Biotin) method yielding 1031-fold and 2-fold better antigen detection sensitivity compared to commonly used immobilization methods: direct physical adsorption and NHS-Biotin functionalization, respectively. Utilization of the UV-NBS(Biotin) method for site-specific conjugation to Fab fragment represents a proof of concept use of Fab fragment for various diagnostic and therapeutic applications with numerous fluorescent probes, affinity molecules and peptides. © 2015 Wiley Periodicals, Inc.

  6. Site Specific Advisory Board initiative, evaluation survey results supplementary appendix: Summary of individual site results

    International Nuclear Information System (INIS)

    1996-08-01

    This Appendix presents results of the Site-Specific Advisory Board (SSAB) Initiative for each of the 11 sites that participated in the survey. These individual results are a supplement to the June 1996 Summary Report which presented overall survey results. Results are presented in 11 sections, arranged alphabetically by site. Each section includes a series of figures and tables that parallel those presented in the Summary Report. To facilitate comparison, figures are presented both for the individual site and for the overall long survey. The sequence of sections is: Fernald, Hanford, Idaho, Los Alamos, Monticello, Nevada, Pantex, Rocky Flats, St. Louis, Sandia, and Savannah River

  7. Site-Specific Biomolecule Labeling with Gold Clusters

    OpenAIRE

    Ackerson, Christopher J.; Powell, Richard D.; Hainfeld, James F.

    2010-01-01

    Site-specific labeling of biomolecules in vitro with gold clusters can enhance the information content of electron cryomicroscopy experiments. This chapter provides a practical overview of well-established techniques for forming biomolecule/gold cluster conjugates. Three bioconjugation chemistries are covered: Linker-mediated bioconjugation, direct gold–biomolecule bonding, and coordination-mediated bonding of nickel(II) nitrilotriacetic acid (NTA)-derivatized gold clusters to polyhistidine (...

  8. Site observational work plan for the UMTRA project site at Grand Junction, Colorado

    International Nuclear Information System (INIS)

    1996-01-01

    This site observational work plan (SOWP) is one of the first Uranium Mill Tailings Remedial Action (UMTRA) Ground Water Project documents developed to select a compliance strategy that meets the UMTRA ground water standards for the Grand Junction site. This SOWP applies information about the Grand Junction site to the compliance strategy selection framework developed in the UMTRA Ground Water Project draft programmatic environmental impact statement. This risk-based, decision-making framework identifies the decision logic for selecting compliance strategies that could be used to meet the ground water standards. The US Department of Energy (DOE) goal is to implement a cost-effective site strategy that complies with the ground water standards and protects human health and the environment. Based on an evaluation of the site characterization and risk assessment data available for the preparation of this SOWP, DOE proposes that the most likely compliance strategy for the Grand Junction site is no remediation with the application of supplemental standards. This proposed strategy is based on a conceptual site model that indicates site-related contamination is confined to a limited-use aquifer as defined in the ground water standards. The conceptual model demonstrates that the uranium processing-related contamination at the site has affected the unconfined alluvial aquifer, but not the deeper confined aquifer

  9. Site-specific analysis of the cobbly soils at the Grand Junction processing site

    International Nuclear Information System (INIS)

    1992-06-01

    This report describes a recent site-specific analysis to evaluate the necessity of a recommendation to install a slurry trench around the Grand Junction processing site. The following analysis addresses the cobbly nature of the site's radiologically contaminated foundation soil, reassesses the excavation depths based on bulk radionuclide concentrations, and presents data-based arguments that support the elimination of the initially proposed slurry trench. The slurry trench around the processing site was proposed by the Remedial Action Contractor (RAC) to minimize the amount of water encountered during excavation. The initial depths of excavation developed during conceptual design, which indicated the need for a slurry wall, were reexamined as part of this analysis. This reanalysis, based on bulk concentrations of a cobbly subsoil, supports decreasing the original excavation depth, limiting the dewatering quantities to those which can be dissipated by normal construction activities. This eliminates the need for a slurry trench andseparate water treatment prior to permitted discharge

  10. Site-Specific ecological risk assessment. Case-study 2

    DEFF Research Database (Denmark)

    Jensen, John

    “Development of a decision support system for sustainable management of contaminated land by linking bioavailability, ecological risk and ground water pollution of organic pollutants”or in short “LIBERATION”. The presentation includes examples on how to scale and integrate the results from various scientific......The decision supporting and integrating assessment tool, TRIAD, is used site-specific on PAH- and heavy metal contaminated sites in Denmark. The various aspects of the TRIAD approach are used on a set of chemistry-, ecotoxicology- and ecology related data collected among others in the EU project...

  11. A geotechnical investigation of a deep ocean site

    International Nuclear Information System (INIS)

    Freeman, T.J.; Schuttenhelm, R.T.E.

    1990-01-01

    A site investigation in deep water often relies solely on laboratory tests to evaluate the geotechnical properties of the sediments. This imposes two fundamental limitations on the investigation: The maximum depth to which the properties can be profiled and the uncertainty of sample disturbance and de-pressurization effects on the measured data. This paper uses results from investigations performed in a water depth of 5.4 km at an abyssal plain site, Great Meteor East (GME), to illustrate how ambiguities can arise in laboratory measurements of strength, and discusses how a simple in-situ test, the expendable penetrator, can be used to corroborate the laboratory data

  12. Site-specific seismic probabilistic tsunami hazard analysis: performances and potential applications

    Science.gov (United States)

    Tonini, Roberto; Volpe, Manuela; Lorito, Stefano; Selva, Jacopo; Orefice, Simone; Graziani, Laura; Brizuela, Beatriz; Smedile, Alessandra; Romano, Fabrizio; De Martini, Paolo Marco; Maramai, Alessandra; Piatanesi, Alessio; Pantosti, Daniela

    2017-04-01

    Seismic Probabilistic Tsunami Hazard Analysis (SPTHA) provides probabilities to exceed different thresholds of tsunami hazard intensity, at a specific site or region and in a given time span, for tsunamis caused by seismic sources. Results obtained by SPTHA (i.e., probabilistic hazard curves and inundation maps) represent a very important input to risk analyses and land use planning. However, the large variability of source parameters implies the definition of a huge number of potential tsunami scenarios, whose omission could lead to a biased analysis. Moreover, tsunami propagation from source to target requires the use of very expensive numerical simulations. At regional scale, the computational cost can be reduced using assumptions on the tsunami modeling (i.e., neglecting non-linear effects, using coarse topo-bathymetric meshes, empirically extrapolating maximum wave heights on the coast). On the other hand, moving to local scale, a much higher resolution is required and such assumptions drop out, since detailed inundation maps require significantly greater computational resources. In this work we apply a multi-step method to perform a site-specific SPTHA which can be summarized in the following steps: i) to perform a regional hazard assessment to account for both the aleatory and epistemic uncertainties of the seismic source, by combining the use of an event tree and an ensemble modeling technique; ii) to apply a filtering procedure which use a cluster analysis to define a significantly reduced number of representative scenarios contributing to the hazard of a specific target site; iii) to perform high resolution numerical simulations only for these representative scenarios and for a subset of near field sources placed in very shallow waters and/or whose coseismic displacements induce ground uplift or subsidence at the target. The method is applied to three target areas in the Mediterranean located around the cities of Milazzo (Italy), Thessaloniki (Greece) and

  13. Human Health and Ecological Risk Assessment Work Plan Mud Pit Release Sites, Amchitka Island, Alaska

    Energy Technology Data Exchange (ETDEWEB)

    DOE/NV

    2001-03-12

    This Work Plan describes the approach that will be used to conduct human health and ecological risk assessments for Amchitka Island, Alaska, which was utilized as an underground nuclear test site between 1965 and 1971. During this period, the U.S. Atomic Energy Commission (now the U.S. Department of Energy) conducted two nuclear tests (known as Long Shot and Milrow) and assisted the U.S. Department of Defense with a third test (known as Cannikin). Amchitka Island is approximately 42 miles long and located 1,340 miles west-southwest of Anchorage, Alaska, in the western end of the Aleutian Island archipelago in a group of islands known as the Rat Islands. Historically including deep drilling operations required large volumes of drilling mud, a considerable amount of which was left on the island in exposed mud pits after testing was completed. Therefore, there is a need for drilling mud pit remediation and risk assessment of historical mud pit releases. The scope of this work plan is to document the environmental objectives and the proposed technical site investigation strategies that will be utilized for the site characterization of the constituents in soil, surface water, and sediment at these former testing sites. Its goal is the collection of data in sufficient quantity and quality to determine current site conditions, support a risk assessment for the site surfaces, and evaluate what further remedial action is required to achieve permanent closure of these three sites that will protect both human health and the environment. Suspected compounds of potential ecological concern for investigative analysis at these sites include diesel-range organics, polyaromatic hydrocarbons, polychlorinated biphenyls, volatile organic compounds, and chromium. The results of these characterizations and risk assessments will be used to evaluate corrective action alternatives to include no further action, the implementation of institutional controls, capping on site, or off-sit e

  14. Modified TCLP test for evaluating the leachability of site-specific wastes

    International Nuclear Information System (INIS)

    Pier, J.

    1996-01-01

    The Weldon Spring Site Remedial Action Project (WSSRAP) has developed a site-specific test to assess the leachability of wastes that will be placed in its on-site disposal cell. This test is modelled after the TCLP, but examines an expanded list of parameters and uses an extraction solution that is representative of conditions that are expected to exist in the disposal facility. Following the same logic that guided development of TCLP protocols, the WSSRAP developed concentration guidelines for non-TCLP parameters that were contaminants of concern in its wastes. Response actions, specific to the WSSRAP cell and wastes, were also developed to address constituents that failed to meet these guides. From 1955 to 1966, the US Atomic Energy Commission operated a uranium feed materials plant on this site. Nitroaromatic, and later, radiological wastes were disposed of in the quarry from 1945 until 1970. This paper describes testing to determine whether contaminant concentrations in leachates derived from the major waste-types that will be placed in its on-site disposal cell conform with the Department of Energy's (DOE) as low as reasonably achievable (ALARA) policy. Although the WSSRAP will continue to use the TCLP test to determine if any waste is classified RCRA-hazardous, the site-specific test described in this paper will be used to further assess whether leachate from any waste-type has the potential to adversely impact groundwater

  15. Results of the 1987 Archeological Investigations at the Travis 2 Site, 39WW15, Walworth County, South Dakota

    Science.gov (United States)

    1988-09-01

    only approximately 25 percent of the ground surface was visible during field work. The beach areas of the site are essentially barren of vegetation so...7.6. Pollen types observed in samples from the Travis 2 site, 39WW15. Common Name ARBOREAL POLLEN: Betulaceae Birch family Pinus Pine Populus...David W. (editor) 1981 Archaeoloical Investigations at the Rainbow Site Plymouth Countyifowa. Luther Coll ige-rchaeologica’Research Center, Decorah

  16. Investigative studies for the use of an inactive asbestos mine as a disposal site for asbestos wastes.

    Science.gov (United States)

    Gidarakos, Evangelos; Anastasiadou, Kalliopi; Koumantakis, Emmanuil; Nikolaos, Stappas

    2008-05-30

    Although, according to European legislation the use of Asbestos Containing Materials is forbidden, many buildings in Greece still contain asbestos products, which must be removed at some point in the near future. Therefore, suitable disposal sites must be found within Greece, so that the unverified disposal of asbestos waste in municipal waste Landfills is brought to an end. In the present work, an innovative approach to the disposal problem of asbestos wastes in Greece has been examined, through a risk assessment analysis of the inactive asbestos mine of Northern Greece and an evaluation of its suitability as a disposal site for asbestos wastes in the future. According to the research carried out, two areas (Site 1 and Site 2) inside the mine area are suitable for the construction of a disposal site for asbestos wastes. The geological investigations showed that in Site 1 and Site 2 ultrabasic rocks of ophiolite complex were prevalent, which have been intensely serpentinized and converted into the fibrous shape of serpentine (asbestos). Concentrations of hazardous substances such as heavy metals in the soil of Site 1 and Site 2 oscillate at low levels, with the exception of the concentrations of nickel and chrome which are high. The investigative work also included the collection of meteorological data and the monitoring of the water level of the artificial lake, which has developed inside the open mine. The main aim is to safely dispose asbestos wastes inside the mine, to minimize any pollution of the wider vicinity of the mine, as well as to engage in restoration activities.

  17. Geological and hydrological investigations at Sidi Kreir Site, west of Alexandria, Egypt

    International Nuclear Information System (INIS)

    El-Shazly, E.M.; Shehata, W.M.; Somaida, M.A.

    1978-01-01

    Sidi-Kreir site lies along the Mediterranean Sea coast at km 30 to km 33 westwards from the center of the city of Alexandria. The studied site covers approximately 10 km 2 from the Mediterranean Sea northward to Mallehet (Lake) Maryut southward. This study includes the results of geological investigation of the site both structurally and stratigraphically, and the groundwater conditions, in relation to the erection of a nuclear power station in the site. The surface geology has been mapped using aerial photographs on scale of 1:20,000. Twenty-five drillholes were core-drilled in order to outline the subsurface geology and to observe the groundwater fluctuations. Selected core samples and soil samples were tested geologically in thin sections, physically and mechanically. Water samples were also collected and tested for total dissolved solids and specific weight. Groundwater level fluctuations were observed for a period of one year in 75 wells and drillholes. Furthermore three pumping tests were conducted to estimate the hydraulic properties of the freshwater aquifer. These properties were also calculated using the core samples data

  18. US DOE-EM On-Site Disposal Cell Working Group - Fostering Communication On Performance Assessment Challenges

    Energy Technology Data Exchange (ETDEWEB)

    Seitz, Roger R. [Savannah River Site (SRS), Aiken, SC (United States); Suttora, Linda C. [U.S. Department of Energy, Office of Site Restoration, Germantown, MD (United States); Phifer, Mark [Savannah River Site (SRS), Aiken, SC (United States)

    2014-03-01

    On-site disposal cells are in use and being considered at several U.S. Department of Energy (USDOE) sites as the final disposition for large amounts of waste associated with cleanup of contaminated areas and facilities. These facilities are typically developed with regulatory oversight from States and/or the US Environmental Protection Agency (USEPA) in addition to USDOE. The facilities are developed to meet design standards for disposal of hazardous waste as well as the USDOE performance based standards for disposal of radioactive waste. The involvement of multiple and different regulators for facilities across separate sites has resulted in some differences in expectations for performance assessments and risk assessments (PA/RA) that are developed for the disposal facilities. The USDOE-EM Office of Site Restoration formed a working group to foster improved communication and sharing of information for personnel associated with these Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) disposal cells and work towards more consistent assumptions, as appropriate, for technical and policy considerations related to performance and risk assessments in support of a Record of Decision and Disposal Authorization Statement. The working group holds teleconferences, as needed, focusing on specific topics of interest. The topics addressed to date include an assessment of the assumptions used for performance assessments and risk assessments (PA/RAs) for on-site disposal cells, requirements and assumptions related to assessment of inadvertent intrusion, DOE Manual 435.1-1 requirements, and approaches for consideration of the long-term performance of liners and covers in the context of PAs. The working group has improved communication among the staff and oversight personnel responsible for onsite disposal cells and has provided a forum to identify and resolve common concerns.

  19. Data base for site specific migration analysis of radioactive elements in repositories

    Energy Technology Data Exchange (ETDEWEB)

    Hadermann, J

    1982-01-01

    Migration analysis is of considerable importance in long-term safety aspects of radioactive waste repositories. The present work gives the data base for a selected part of a comprehensive geosphere transport calculation. We restrict ourselves to a critical evaluation of parameters pertinent to the migration analysis of the /sup 245/Cm chain. This includes the important nuclide /sup 237/Np. With these we are able to perform a site specific calculation for repositories planned in deep geologic formations in Switzerland. It is shown that the granitic basement induces strong time delays in nuclide migration. In contrast to that, the overlaying sedimentary layers cause primarily a dilution of the radionuclide concentrations.

  20. Site-Specific Biomolecule Labeling with Gold Clusters

    Science.gov (United States)

    Ackerson, Christopher J.; Powell, Richard D.; Hainfeld, James F.

    2013-01-01

    Site-specific labeling of biomolecules in vitro with gold clusters can enhance the information content of electron cryomicroscopy experiments. This chapter provides a practical overview of well-established techniques for forming biomolecule/gold cluster conjugates. Three bioconjugation chemistries are covered: Linker-mediated bioconjugation, direct gold–biomolecule bonding, and coordination-mediated bonding of nickel(II) nitrilotriacetic acid (NTA)-derivatized gold clusters to polyhistidine (His)-tagged proteins. PMID:20887859

  1. Spatial Distribution and Site-Specific Spraying of Main Sucking Pests of Elm Trees.

    Science.gov (United States)

    Karimzadeh, R; Iranipour, S

    2017-06-01

    Elm trees are important landscape trees and sucking insects weaken the elm trees and produce large amounts of honeydew. The main objectives of this study were to identify main honeydew-producing pests of elm trees and do site-specific spraying against these pests. To map the spatial distribution of the sucking pests in the large scale, the study area was divided into 40 × 40 m grids and one tree was chosen randomly from each grid (a total of 55 trees). These trees were sampled twice a year in 2011 and 2012. Each sample was a 30-cm branch terminal. Eight samples were taken from each tree in four cardinal directions and two canopy levels. The number of sucking insects and leaves of each sample were counted and recorded. Spatial analysis of the data was carried out using geostatistics. Kriging was used for producing prediction maps. Insecticide application was restricted to the regions with populations higher than threshold. To identify within-tree distribution of the honeydew-producing pests, six and four elm trees were chosen in 2011 and 2012 respectively, and sampled weekly. These trees were sampled as described previously. European elm scale (EES), Gossyparia spuria (Modeer) and two species of aphids were the dominant honeydew-producing pests. The results revealed that the effects of direction, canopy level and their interactions on insect populations were not statistically significant (P < 0.05). Site-specific spraying decreased the amount of insecticides used by ca. 20%, while satisfactory control of the sucking pests and honeydew excretion was obtained. Considering the environmental and economic benefits of site-specific spraying, it is worth doing more complementary works in this area.

  2. Corrective Action Investigation Plan for Corrective Action Unit 571: Area 9 Yucca Flat Plutonium Dispersion Sites, Nevada National Security Site, Nevada, Revision 0

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, Bernadine; Matthews, Patrick

    2013-07-01

    CAU 571 is a grouping of sites where there has been a suspected release of contamination associated with nuclear testing. This document describes the planned investigation of CAU 571, which comprises the following corrective action sites (CASs): • 09-23-03, Atmospheric Test Site S-9F • 09-23-04, Atmospheric Test Site T9-C • 09-23-12, Atmospheric Test Site S-9E • 09-23-13, Atmospheric Test Site T-9D • 09-45-01, Windrows Crater These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives (CAAs). Additional information will be obtained by conducting a corrective action investigation before evaluating CAAs and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable CAAs that will be presented in the investigation report. The sites will be investigated based on the data quality objectives (DQOs) developed on March 6, 2013, by representatives of the Nevada Division of Environmental Protection and the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office (now the Nevada Field Office). The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 571. The site investigation process will also be conducted in accordance with the Soils Activity Quality Assurance Plan, which establishes requirements, technical planning, and general quality practices to be applied to this activity. The potential contamination sources associated with CAU 571 CASs are from nuclear testing activities. The DQO process resulted in an assumption that total effective dose (TED) within a default contamination boundary exceeds the final action level (FAL) and requires corrective action. The presence and nature of contamination outside the default

  3. Drainage filter technologies to mitigate site-specific phosphorus losses

    DEFF Research Database (Denmark)

    Kjærgaard, Charlotte; Heckrath, Goswin Johann; Iversen, Bo Vangsø

    2014-01-01

    -specific nutrient losses in drainage. The “SUPREME-TECH” project (2010-2015), funded by the Danish Strategic Research Council, aims at providing the scientific basis for developing cost-effective drainage filter technologies to retain P in agricultural drainage waters. The project studies different approaches...... high risks areas of P loss and applying site-specific measures therefore seems a more cost-efficient approach. The Danish Commission for Nature and Agriculture has now called for a shift of paradigm towards targeted mitigation and development of new, cost-efficient technologies to mitigate site......-scale surface-flow constructed wetland. In the former, various natural and industrial P filter substrates have been tested for their ability to reduce inlet P concentrations to below environmental threshold values (

  4. SPEER-SERVER: a web server for prediction of protein specificity determining sites.

    Science.gov (United States)

    Chakraborty, Abhijit; Mandloi, Sapan; Lanczycki, Christopher J; Panchenko, Anna R; Chakrabarti, Saikat

    2012-07-01

    Sites that show specific conservation patterns within subsets of proteins in a protein family are likely to be involved in the development of functional specificity. These sites, generally termed specificity determining sites (SDS), might play a crucial role in binding to a specific substrate or proteins. Identification of SDS through experimental techniques is a slow, difficult and tedious job. Hence, it is very important to develop efficient computational methods that can more expediently identify SDS. Herein, we present Specificity prediction using amino acids' Properties, Entropy and Evolution Rate (SPEER)-SERVER, a web server that predicts SDS by analyzing quantitative measures of the conservation patterns of protein sites based on their physico-chemical properties and the heterogeneity of evolutionary changes between and within the protein subfamilies. This web server provides an improved representation of results, adds useful input and output options and integrates a wide range of analysis and data visualization tools when compared with the original standalone version of the SPEER algorithm. Extensive benchmarking finds that SPEER-SERVER exhibits sensitivity and precision performance that, on average, meets or exceeds that of other currently available methods. SPEER-SERVER is available at http://www.hpppi.iicb.res.in/ss/.

  5. “Doing the Wrong Things Right” Site Investigations in Soft Soil

    Science.gov (United States)

    Jamilus, M. H.; Lim, A. J. M. S.; Azhar, A. T. S.; Azmi, M. A. M.

    2016-11-01

    Site investigation is a very important process by which geotechnical, geological and other relevant information which might affect the construction or performance of a civil engineering or building project is acquired. However, common practice in site investigations is not always in accordance to the standard that has been defined. Reliability on the information obtained depends upon several factors that involves correct procedures and competent workers and also supervision. Several examples on site investigation methods are discussed in this paper. Explanation on the difference between the site investigation methods used for real practices in the field and how it should be done are discussed in detail. Therefore, it is hoped that site investigation should always be uniquely planned and should be an interactive and flexible process of discovery and changes according to the condition of the soil.

  6. Geothermal investment analysis with site-specific applications to Roosevelt Hot Springs and Cove Fort-Sulphurdale, Utah

    Energy Technology Data Exchange (ETDEWEB)

    Cassel, T.A.V.; Edelstein, R.H.; Blair, P.D.

    1978-12-01

    The analysis and modeling of investment behavior in the development of hydrothermal electric power facilities are reported. This investment behavior reflects a degree of sensitivity to public policy alternatives concerning taxation and regulation of the resource and its related energy conversion facilities. The objective of the current research is to provide a realistic and theoretically sound means for estimating the impacts of such public policy alternatives. A stochastic simulation model was developed which offers an efficient means for site-specific investment analysis of private sector firms and investors. The results of the first year of work are discussed including the identification, analysis, quantification and modeling of: a decision tree reflecting the sequence of procedures, timing and stochastic elements of hydrothermal resource development projects; investment requirements, expenses and revenues incurred in the exploration, development and utilization of hydrothermal resources for electric power generation; and multiattribute investment decision criteria of the several types of firms in the geothermal industry. An application of the investment model to specific resource sites in the state of Utah is also described. Site specific data for the Known Geothermal Resource Areas of Roosevelt Hot Springs and Cove Fort-Sulphurdale are given together with hypothesized generation capacity growth rates.

  7. The development and site investigation of fume diluter

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Bok Youn; Kang, Chang Hee; Jo, Young Do; Lim, Sang Taek [Korea Institute of Geology Mining and Materials, Taejon (Korea, Republic of)

    1996-12-01

    It is third project year on `Application of mobile diesel equipment in underground mines` for providing appropriate measures to improve underground working environment contaminated by the diesel exhaust pollutants. For reducing the exhaust temperature bellow 70 deg. C to prevent production of the governing pollutant (NO{sub 2}), the fume diluter is verified the most effective device through the site investigation. Therefore, the fume diluter is strongly recommended instead of catalytic converter which is employed presently. The performances derived from the tests are as follows; 1) This device increased air flow to 6.7-8.4 times of the original exhaust, 2) Exhaust temperature can be reduced to 66 deg. C from 161 deg. C, 3) All the pollutants can be reduced to bellow than 30 % of exhaust concentration, 4) This device requires less cost and no maintenance. (author). 4 tabs., 4 figs.

  8. Site observational work plan for the UMTRA Project Site at Grand Junction, Colorado

    International Nuclear Information System (INIS)

    1996-03-01

    The U.S. Department of Energy (DOE) has prepared this initial site observational work plan (SOWP) for the Uranium Mill Tailings Remedial Action (UMTRA) Project site in Grand Junction, Colorado. This SOWP is one of the first UMTRA Ground Water Project documents developed to select a compliance strategy that meets the UMTRA ground water standards (40 CFR Part 192, as amended by 60 FR 2854) for the Grand Junction site. This SOWP applies information about the Grand Junction site to the compliance strategy selection framework developed in the UMTRA Ground Water Project draft programmatic environmental impact statement (PEIS). This risk-based, decision-making framework identifies the decision logic for selecting compliance strategies that could be used to meet the ground water standards. The DOE goal is to use the observational method to implement a cost-effective site strategy that complies with the ground water standards and protects human health and the environment. Based on an evaluation of the site characterization and risk assessment data available for the preparation of this SOWP, DOE proposes that the most likely compliance strategy for the Grand Junction site is no remediation based on the application of supplemental standards. This proposed strategy is based on a conceptual site model that indicates site-related contamination is confined to a limited-use aquifer as defined in the ground water standards

  9. An investigation of emotion experiences at work : a critical incident technique approach / Natalie Booth

    OpenAIRE

    Booth, Natalie

    2013-01-01

    Orientation: Emotions at work have been considered as an important facet of employees’ work life. However, research regarding the investigation of the emotion experiences at work per se has been lacking. Research Purpose: The general objective of this study is to critically investigate what emotion events are experienced and how these events are appraised for them to result in specific emotions. Motivation for the study: Currently a lack of research regarding emotion experiences as a pr...

  10. Site-specific dissociation dynamics of H{sub 2}/D{sub 2} on Ag(111) and Co(0001) and the validity of the site-averaging model

    Energy Technology Data Exchange (ETDEWEB)

    Hu, Xixi [Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, New Mexico 87131 (United States); Institute of Theoretical and Computational Chemistry, Key Laboratory of Mesoscopic Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093 (China); Jiang, Bin [Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, New Mexico 87131 (United States); Department of Chemical Physics, University of Science and Technology of China, Hefei 230026 (China); Xie, Daiqian, E-mail: dqxie@nju.edu.cn, E-mail: hguo@unm.edu [Institute of Theoretical and Computational Chemistry, Key Laboratory of Mesoscopic Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093 (China); Synergetic Innovation Center of Quantum Information and Quantum Physics, University of Science and Technology of China, Hefei, Anhui 230026 (China); Guo, Hua, E-mail: dqxie@nju.edu.cn, E-mail: hguo@unm.edu [Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, New Mexico 87131 (United States)

    2015-09-21

    Dissociative chemisorption of polyatomic molecules on metal surfaces involves high-dimensional dynamics, of which quantum mechanical treatments are computationally challenging. A promising reduced-dimensional approach approximates the full-dimensional dynamics by a weighted average of fixed-site results. To examine the performance of this site-averaging model, we investigate two distinct reactions, namely, hydrogen dissociation on Co(0001) and Ag(111), using accurate first principles potential energy surfaces (PESs). The former has a very low barrier of ∼0.05 eV while the latter is highly activated with a barrier of ∼1.15 eV. These two systems allow the investigation of not only site-specific dynamical behaviors but also the validity of the site-averaging model. It is found that the reactivity is not only controlled by the barrier height but also by the topography of the PES. Moreover, the agreement between the site-averaged and full-dimensional results is much better on Ag(111), though quantitative in neither system. Further quasi-classical trajectory calculations showed that the deviations can be attributed to dynamical steering effects, which are present in both reactions at all energies.

  11. Vika/vox, a novel efficient and specific Cre/loxP-like site-specific recombination system

    Science.gov (United States)

    Karimova, Madina; Abi-Ghanem, Josephine; Berger, Nicolas; Surendranath, Vineeth; Pisabarro, Maria Teresa; Buchholz, Frank

    2013-01-01

    Targeted genome engineering has become an important research area for diverse disciplines, with site-specific recombinases (SSRs) being among the most popular genome engineering tools. Their ability to trigger excision, integration, inversion and translocation has made SSRs an invaluable tool to manipulate DNA in vitro and in vivo. However, sophisticated strategies that combine different SSR systems are ever increasing. Hence, the demand for additional precise and efficient recombinases is dictated by the increasing complexity of the genetic studies. Here, we describe a novel site-specific recombination system designated Vika/vox. Vika originates from a degenerate bacteriophage of Vibrio coralliilyticus and shares low sequence similarity to other tyrosine recombinases, but functionally carries out a similar type of reaction. We demonstrate that Vika is highly specific in catalyzing vox recombination without recombining target sites from other SSR systems. We also compare the recombination activity of Vika/vox with other SSR systems, providing a guideline for deciding on the most suitable enzyme for a particular application and demonstrate that Vika expression does not cause cytotoxicity in mammalian cells. Our results show that Vika/vox is a novel powerful and safe instrument in the ‘genetic toolbox’ that can be used alone or in combination with other SSRs in heterologous hosts. PMID:23143104

  12. Musite, a tool for global prediction of general and kinase-specific phosphorylation sites.

    Science.gov (United States)

    Gao, Jianjiong; Thelen, Jay J; Dunker, A Keith; Xu, Dong

    2010-12-01

    Reversible protein phosphorylation is one of the most pervasive post-translational modifications, regulating diverse cellular processes in various organisms. High throughput experimental studies using mass spectrometry have identified many phosphorylation sites, primarily from eukaryotes. However, the vast majority of phosphorylation sites remain undiscovered, even in well studied systems. Because mass spectrometry-based experimental approaches for identifying phosphorylation events are costly, time-consuming, and biased toward abundant proteins and proteotypic peptides, in silico prediction of phosphorylation sites is potentially a useful alternative strategy for whole proteome annotation. Because of various limitations, current phosphorylation site prediction tools were not well designed for comprehensive assessment of proteomes. Here, we present a novel software tool, Musite, specifically designed for large scale predictions of both general and kinase-specific phosphorylation sites. We collected phosphoproteomics data in multiple organisms from several reliable sources and used them to train prediction models by a comprehensive machine-learning approach that integrates local sequence similarities to known phosphorylation sites, protein disorder scores, and amino acid frequencies. Application of Musite on several proteomes yielded tens of thousands of phosphorylation site predictions at a high stringency level. Cross-validation tests show that Musite achieves some improvement over existing tools in predicting general phosphorylation sites, and it is at least comparable with those for predicting kinase-specific phosphorylation sites. In Musite V1.0, we have trained general prediction models for six organisms and kinase-specific prediction models for 13 kinases or kinase families. Although the current pretrained models were not correlated with any particular cellular conditions, Musite provides a unique functionality for training customized prediction models

  13. A genome-wide screen in human embryonic stem cells reveals novel sites of allele-specific histone modification associated with known disease loci

    LENUS (Irish Health Repository)

    Prendergast, James G D

    2012-05-19

    AbstractBackgroundChromatin structure at a given site can differ between chromosome copies in a cell, and such imbalances in chromatin structure have been shown to be important in understanding the molecular mechanisms controlling several disease loci. Human genetic variation, DNA methylation, and disease have been intensely studied, uncovering many sites of allele-specific DNA methylation (ASM). However, little is known about the genome-wide occurrence of sites of allele-specific histone modification (ASHM) and their relationship to human disease. The aim of this study was to investigate the extent and characteristics of sites of ASHM in human embryonic stem cells (hESCs).ResultsUsing a statistically rigorous protocol, we investigated the genomic distribution of ASHM in hESCs, and their relationship to sites of allele-specific expression (ASE) and DNA methylation. We found that, although they were rare, sites of ASHM were substantially enriched at loci displaying ASE. Many were also found at known imprinted regions, hence sites of ASHM are likely to be better markers of imprinted regions than sites of ASM. We also found that sites of ASHM and ASE in hESCs colocalize at risk loci for developmental syndromes mediated by deletions, providing insights into the etiology of these disorders.ConclusionThese results demonstrate the potential importance of ASHM patterns in the interpretation of disease loci, and the protocol described provides a basis for similar studies of ASHM in other cell types to further our understanding of human disease susceptibility.

  14. Complex Sentence Comprehension and Working Memory in Children with Specific Language Impairment

    Science.gov (United States)

    Montgomery, James W.; Evans, Julia L.

    2009-01-01

    Purpose: This study investigated the association of 2 mechanisms of working memory (phonological short-term memory [PSTM], attentional resource capacity/allocation) with the sentence comprehension of school-age children with specific language impairment (SLI) and 2 groups of control children. Method: Twenty-four children with SLI, 18 age-matched…

  15. Joint assessment of specific sites for ITER begins at Clarington

    International Nuclear Information System (INIS)

    Stewart, M.J.

    2002-01-01

    Clarington, Ontario, Canada was the subject of the first official stage of the Joint Assessment of Specific Sites (JASS) for the ITER Project. The Assessment is part of the Negotiations process and is being conducted by an ad-hoc group of the Negotiators with representatives from Canada, the European Union, Japan and Russian Federation, supported by the ITER international team. The evaluation was conducted over four days through a series of visits to the site itself, a review of materials included in Canada's submission to host ITER, presentations from group leading Canada's offer and experts on specific aspects of the offer

  16. Site-specific parameter values for the Nuclear Regulatory Commission's food pathway dose model

    International Nuclear Information System (INIS)

    Hamby, D.M.

    1992-01-01

    Routine operations at the Savannah River Site (SRS) in Western South Carolina result in radionuclide releases to the atmosphere and to the Savannah River. The resulting radiation doses to the off-site maximum individual and the off-site population within 80 km of the SRS are estimated on a yearly basis. These estimates are currently generated using dose models prescribed for the commercial nuclear power industry by the Nuclear Regulatory Commission (NRC). The NRC provides default values for dose-model parameters for facilities without resources to develop site-specific values. A survey of land- and water-use characteristics for the Savannah River area has been conducted to determine site-specific values for water recreation, consumption, and agricultural parameters used in the NRC Regulatory Guide 1.109 (1977) dosimetric models. These site parameters include local characteristics of meat, milk, and vegetable production; recreational and commercial activities on the Savannah River; and meat, milk, vegetable, and seafood consumption rates. This paper describes how parameter data were obtained at the Savannah River Site and the impacts of such data on off-site dose. Dose estimates using site-specific parameter values are compared to estimates using the NRC default values

  17. Active site mutations change the cleavage specificity of neprilysin.

    Directory of Open Access Journals (Sweden)

    Travis Sexton

    Full Text Available Neprilysin (NEP, a member of the M13 subgroup of the zinc-dependent endopeptidase family is a membrane bound peptidase capable of cleaving a variety of physiological peptides. We have generated a series of neprilysin variants containing mutations at either one of two active site residues, Phe(563 and Ser(546. Among the mutants studied in detail we observed changes in their activity towards leucine(5-enkephalin, insulin B chain, and amyloid β(1-40. For example, NEP(F563I displayed an increase in preference towards cleaving leucine(5-enkephalin relative to insulin B chain, while mutant NEP(S546E was less discriminating than neprilysin. Mutants NEP(F563L and NEP(S546E exhibit different cleavage site preferences than neprilysin with insulin B chain and amyloid ß(1-40 as substrates. These data indicate that it is possible to alter the cleavage site specificity of neprilysin opening the way for the development of substrate specific or substrate exclusive forms of the enzyme with enhanced therapeutic potential.

  18. Site-Specific Bioorthogonal Labeling for Fluorescence Imaging of Intracellular Proteins in Living Cells.

    Science.gov (United States)

    Peng, Tao; Hang, Howard C

    2016-11-02

    Over the past years, fluorescent proteins (e.g., green fluorescent proteins) have been widely utilized to visualize recombinant protein expression and localization in live cells. Although powerful, fluorescent protein tags are limited by their relatively large sizes and potential perturbation to protein function. Alternatively, site-specific labeling of proteins with small-molecule organic fluorophores using bioorthogonal chemistry may provide a more precise and less perturbing method. This approach involves site-specific incorporation of unnatural amino acids (UAAs) into proteins via genetic code expansion, followed by bioorthogonal chemical labeling with small organic fluorophores in living cells. While this approach has been used to label extracellular proteins for live cell imaging studies, site-specific bioorthogonal labeling and fluorescence imaging of intracellular proteins in live cells is still challenging. Herein, we systematically evaluate site-specific incorporation of diastereomerically pure bioorthogonal UAAs bearing stained alkynes or alkenes into intracellular proteins for inverse-electron-demand Diels-Alder cycloaddition reactions with tetrazine-functionalized fluorophores for live cell labeling and imaging in mammalian cells. Our studies show that site-specific incorporation of axial diastereomer of trans-cyclooct-2-ene-lysine robustly affords highly efficient and specific bioorthogonal labeling with monosubstituted tetrazine fluorophores in live mammalian cells, which enabled us to image the intracellular localization and real-time dynamic trafficking of IFITM3, a small membrane-associated protein with only 137 amino acids, for the first time. Our optimized UAA incorporation and bioorthogonal labeling conditions also enabled efficient site-specific fluorescence labeling of other intracellular proteins for live cell imaging studies in mammalian cells.

  19. Calculation of risk for workers in dust working site

    Directory of Open Access Journals (Sweden)

    Geldová Erika

    2004-03-01

    Full Text Available The fibrogeneous dust is considered as a specific harmful substance in the mine working site. Such kind of dust cumulates in lungs and this fact usually results in lungs dusting, so - called pneumoconiosis. Thus, dustiness risk poses a probability of lungs damage by pneumoconiosis. For the calculation of dustiness risk it is needed to know the following data: the value of average dustiness kC in the working site per a definite time period, the dispersivity of dust “D” (it determines a portion of dust particles with a diameter under 5 µm, so - called respirable particles and the percentage content of quartz Qr in the respirable grain size fraction.The contribution presents the calculation of dustiness risk “R” according to the equation (1, where “R” is in percentage, “ša” is the analytically specific harmfulness and “KDc” is the total cumulative dust dose received by worker in time of its dust exposure.The total cumulative dust dose is calculated on the basis of the equation (4, where “kc” is the average dust concentration in the assessed time period, t–time of exposure, V –average amount of air inspired by exposed worker per time unit ( standardized on the value of 1,2 m3h-1,10-6-recalculation from mg to kg for “KDc”.If the values of “Qr”, “D” and “kc” during the worker exposure on a definite workplace are constant, the dustiness risk “R” is calculated according to the equation (1 and (5 respectively. In the case of “n” time intervals in that the values “Qr”, “D” and “kc” are known the dustiness risk “R” is calculated according to the equation (7. The total personal risk of worker is given by the equation (8.Conclusively, the influence of parameters change namely “Qr”, “D” and “kc” on the value of dustiness risk per equal time period is reported.

  20. Microbial profile comparisons of saliva, pooled and site-specific subgingival samples in periodontitis patients.

    Directory of Open Access Journals (Sweden)

    Daniel Belstrøm

    Full Text Available The purpose of this study was to compare microbial profiles of saliva, pooled and site-specific subgingival samples in patients with periodontitis. We tested the hypotheses that saliva can be an alternative to pooled subgingival samples, when screening for presence of periopathogens.Site specific subgingival plaque samples (n = 54, pooled subgingival plaque samples (n = 18 and stimulated saliva samples (n = 18 were collected from 18 patients with generalized chronic periodontitis. Subgingival and salivary microbiotas were characterized by means of HOMINGS (Human Oral Microbe Identification using Next Generation Sequencing and microbial community profiles were compared using Spearman rank correlation coefficient.Pronounced intraindividual differences were recorded in site-specific microbial profiles, and site-specific information was in general not reflected by pooled subgingival samples. Presence of Porphyromonas gingivalis, Treponema denticola, Prevotella intermedia, Filifactor alocis, Tannerella forsythia and Parvimona micra in site-specific subgingival samples were detected in saliva with an AUC of 0.79 (sensitivity: 0.61, specificity: 0.94, compared to an AUC of 0.76 (sensitivity: 0.56, specificity: 0.94 in pooled subgingival samples.Site-specific presence of periodontal pathogens was detected with comparable accuracy in stimulated saliva samples and pooled subgingival plaque samples. Consequently, saliva may be a reasonable surrogate for pooled subgingival samples when screening for presence of periopathogens. Future large-scale studies are needed to confirm findings from this study.

  1. Corrective Action Investigation Plan for Corrective Action Unit 190: Contaminated Waste Sites Nevada Test Site, Nevada, Rev. No.: 0

    International Nuclear Information System (INIS)

    Wickline, Alfred

    2006-01-01

    Corrective Action Unit (CAU) 190 is located in Areas 11 and 14 of the Nevada Test Site, which is 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 190 is comprised of the four Corrective Action Sites (CASs) listed below: (1) 11-02-01, Underground Centrifuge; (2) 11-02-02, Drain Lines and Outfall; (3) 11-59-01, Tweezer Facility Septic System; and (4) 14-23-01, LTU-6 Test Area. These sites are being investigated because existing information is insufficient on the nature and extent of potential contamination to evaluate and recommend corrective action alternatives. Additional information will be obtained before evaluating corrective action alternatives and selecting the appropriate corrective action for each CAS by conducting a corrective action investigation (CAI). The results of the field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the Corrective Action Decision Document. The sites will be investigated based on the data quality objectives (DQOs) developed on August 24, 2006, by representatives of the Nevada Division of Environmental Protection; U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office; Stoller-Navarro Joint Venture, and National Security Technologies, LLC. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 190. The scope of the CAU 190 CAI includes the following activities: (1) Move surface debris and/or materials, as needed, to facilitate sampling; (2) Conduct radiological and geophysical surveys; (3) Perform field screening; (4) Collect and submit environmental samples for laboratory analysis to determine whether contaminants of concern (COCs) are present; (5) If COCs are present, collect additional step-out samples to define the lateral and vertical extent of the contamination; (6) Collect samples of source material, if present

  2. Attitudes toward smoking restrictions in work sites, restaurants, and bars among North Carolinians.

    Science.gov (United States)

    Maguire, Rachel Loflin; Brinkley, Jason; Mansfield, Christopher

    2010-01-01

    Public support for smoking restrictions has increased in recent years, but support varies among groups and according to where restrictions should apply. National studies show that Americans are less likely to favor smoking restrictions in restaurants and bars than at other work sites but that the support varies across segments of the population. A full examination of the changes and status of attitudes toward smoking restrictions by site and across subgroups in North Carolina has not been undertaken. Data from US Census Bureau Current Population Surveys conducted during 2001-2002 and 2006-2007 were analyzed. Trends in attitudes toward smoke-free policies at indoor work sites, restaurants, and bars are presented overall and by occupation, smoking status, income, race/ethnicity, workplace smoking policy, age, sex, and education. Logistic regression was used to identify key factors predicting support for smoke-free policies at work sites. Support for smoke-free policies increased by at least 7.4 percentage points at each venue between 2001-2002 and 2006-2007. In 2006-2007, the strongest public support for smoking restrictions was reported for work sites (69.6%), followed by restaurants (52.3%) and bars (36.1%). Whether a person smokes is the strongest predictor of their attitude about smoking restrictions in indoor work sites. Data are self-reported, from independent samples, and lack county identifiers. There is substantial and increasing public support for smoke-free policies in North Carolina. These findings show extensive support for extending smoking bans to all indoor work sites, with nearly 70% of respondents in 2006-2007 favoring smoke-free work sites.

  3. SFR site investigation. Bedrock Hydrogeochemistry

    International Nuclear Information System (INIS)

    Nilsson, Ann-Chatrin; Tullborg, Eva-Lena; Smellie, John; Gimeno, Maria J.; Gomez, Javier B.; Auque, Luis F.; Sandstroem, Bjoern; Pedersen, Karsten

    2011-11-01

    There are plans that the final repository for low and intermediate level radioactive waste, SFR, located about 150 km north of Stockholm, will be extended. Geoscientific studies to define and characterise a suitable bedrock volume for the extended repository have been carried out from 2007 to 2011, and have included the drilling and evaluation of seven new core drilled and four percussion boreholes. These new data, together with existing data extending back to 1985, have been interpreted and modelled in order to provide the necessary information for safety assessment and repository design. This report presents the final hydrogeochemical site description for the SFR site, and will constitute a background report for the integrated site description (the SFR Site Descriptive Model version 1.0) together with corresponding reports from the geological and hydrogeological disciplines. Most of the hydrogeochemical data from the field investigations consist of major ions and isotopes together with sporadic gas, microbe and measured redox data. Despite the close proximity of the Forsmark site, few data from this source are of relevance because of the shallow nature of the SFR site, the fact that SFR is located beneath the Baltic Sea and also the drawdown/upconing impacts of its construction on the hydrogeochemistry. This artificially imposed dynamic flow system is naturally more prevalent along major deformation fracture zones of higher transmissivity, whilst lower transmissive fractures together with the less transmissive bedrock masses between major deformation zones, still retain some evidence of the natural groundwater mixing patterns established prior to the SFR construction. The groundwaters in the SFR dataset cover a depth down to -250 m.a.s.l. with single sampling locations at -300 and -400 m.a.s.l. and represent a relatively limited salinity range (1,500 to 5,500 mg/L chloride). However, the δ 18 O values show a wide variation (-15.5 to -7.5 per mille V

  4. SFR site investigation. Bedrock Hydrogeochemistry

    Energy Technology Data Exchange (ETDEWEB)

    Nilsson, Ann-Chatrin [Geosigma AB, Uppsala (Sweden); Tullborg, Eva-Lena [Terralogica AB, Graabo (Sweden); Smellie, John [Conterra AB, Uppsala (Sweden); Gimeno, Maria J.; Gomez, Javier B.; Auque, Luis F. [Univ. of Zaragoza, Zaragoza (Spain); Sandstroem, Bjoern [WSP Sverige AB, Goeteborg (Sweden); Pedersen, Karsten [Micans AB, Moelnlycke (Sweden)

    2011-11-15

    There are plans that the final repository for low and intermediate level radioactive waste, SFR, located about 150 km north of Stockholm, will be extended. Geoscientific studies to define and characterise a suitable bedrock volume for the extended repository have been carried out from 2007 to 2011, and have included the drilling and evaluation of seven new core drilled and four percussion boreholes. These new data, together with existing data extending back to 1985, have been interpreted and modelled in order to provide the necessary information for safety assessment and repository design. This report presents the final hydrogeochemical site description for the SFR site, and will constitute a background report for the integrated site description (the SFR Site Descriptive Model version 1.0) together with corresponding reports from the geological and hydrogeological disciplines. Most of the hydrogeochemical data from the field investigations consist of major ions and isotopes together with sporadic gas, microbe and measured redox data. Despite the close proximity of the Forsmark site, few data from this source are of relevance because of the shallow nature of the SFR site, the fact that SFR is located beneath the Baltic Sea and also the drawdown/upconing impacts of its construction on the hydrogeochemistry. This artificially imposed dynamic flow system is naturally more prevalent along major deformation fracture zones of higher transmissivity, whilst lower transmissive fractures together with the less transmissive bedrock masses between major deformation zones, still retain some evidence of the natural groundwater mixing patterns established prior to the SFR construction. The groundwaters in the SFR dataset cover a depth down to -250 m.a.s.l. with single sampling locations at -300 and -400 m.a.s.l. and represent a relatively limited salinity range (1,500 to 5,500 mg/L chloride). However, the {delta}{sup 18}O values show a wide variation (-15.5 to -7.5 per mille V

  5. Corrective Action Investigation Plan for Corrective Action Unit 105: Area 2 Yucca Flat Atmospheric Test Sites Nevada National Security Site, Nevada, Revision 0

    Energy Technology Data Exchange (ETDEWEB)

    Patrick Matthews

    2012-09-01

    Corrective Action Unit (CAU) 105 is located in Area 2 of the Nevada National Security Site, which is approximately 65 miles northwest of Las Vegas, Nevada. CAU 105 is a geographical grouping of sites where there has been a suspected release of contamination associated with atmospheric nuclear testing. This document describes the planned investigation of CAU 105, which comprises the following corrective action sites (CASs): • 02-23-04, Atmospheric Test Site - Whitney • 02-23-05, Atmospheric Test Site T-2A • 02-23-06, Atmospheric Test Site T-2B • 02-23-08, Atmospheric Test Site T-2 • 02-23-09, Atmospheric Test Site - Turk These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives (CAAs). Additional information will be obtained by conducting a corrective action investigation before evaluating CAAs and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable CAAs that will be presented in the Corrective Action Decision Document. The sites will be investigated based on the data quality objectives (DQOs) developed on April 30, 2012, by representatives of the Nevada Division of Environmental Protection and the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 105. The site investigation process will also be conducted in accordance with the Soils Activity Quality Assurance Plan, which establishes requirements, technical planning, and general quality practices to be applied to this activity. The potential contamination sources associated with all CAU 105 CASs are from atmospheric nuclear testing activities. The presence and nature of contamination at CAU

  6. Optimization under Uncertainty of Site-Specific Turbine Configurations: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Quick, Julian; Dykes, Katherine; Graf, Peter; Zahle, Frederik

    2016-11-01

    Uncertainty affects many aspects of wind energy plant performance and cost. In this study, we explore opportunities for site-specific turbine configuration optimization that accounts for uncertainty in the wind resource. As a demonstration, a simple empirical model for wind plant cost of energy is used in an optimization under uncertainty to examine how different risk appetites affect the optimal selection of a turbine configuration for sites of different wind resource profiles. If there is unusually high uncertainty in the site wind resource, the optimal turbine configuration diverges from the deterministic case and a generally more conservative design is obtained with increasing risk aversion on the part of the designer.

  7. Electron paramagnetic resonance spin label titration: a novel method to investigate random and site-specific immobilization of enzymes onto polymeric membranes with different properties

    International Nuclear Information System (INIS)

    Butterfield, D. Allan; Colvin, Joshua; Liu Jiangling; Wang Jianquan; Bachas, Leonidas; Bhattacharrya, Dibakar

    2002-01-01

    The immobilization of biological molecules onto polymeric membranes to produce biofunctional membranes is used for selective catalysis, separation, analysis, and artificial organs. Normally, random immobilization of enzymes onto polymeric membranes leads to dramatic reduction in activity due to chemical reactions involved in enzyme immobilization, multiple-point binding, etc., and the extent of activity reduction is a function of membrane hydrophilicity (e.g. activity in cellulosic membrane >> polysulfone membrane). We have used molecular biology to effect site-specific immobilization of enzymes in a manner that orients the active site away from the polymeric membrane surface, thus resulting in higher enzyme activity that approaches that in solution and in increased stability of the enzyme relative to the enzyme in solution. A prediction of this site-specific method of enzyme immobilization, which in this study with subtilisin and organophosphorus hydrolase consists of a fusion tag genetically added to these enzymes and subsequent immobilization via the anti-tag antibody and membrane-bound protein A, is that the active site conformation will more closely resemble that of the enzyme in solution than is the case for random immobilization. This hypothesis was confirmed using a new electron paramagnetic resonance (EPR) spin label active site titration method that determines the amount of spin label bound to the active site of the immobilized enzyme. This value nearly perfectly matched the enzyme activity, and the results suggested: (a) a spectroscopic method for measuring activity and thus the extent of active enzyme immobilization in membrane, which may have advantages in cases where optical methods can not be used due to light scattering interference; (b) higher spin label incorporation (and hence activity) in enzymes that had been site-specifically immobilized versus random immobilization; (c) higher spin label incorporation in enzymes immobilized onto hydrophilic

  8. Site-specific assessments of the abundance of three inshore dolphin species to inform conservation and management

    Directory of Open Access Journals (Sweden)

    Alexander Mark Brown

    2016-02-01

    requires urgent assessment. An ideal candidate site for a long-term study of snubfin dolphin population dynamics is identified, where trends in abundance and their influencing factors could be investigated. The methods employed herein provide an example of rigorous, site-specific population assessments of inshore dolphins that are broadly applicable to such studies elsewhere.

  9. Hanfor site past practice investigation strategy

    International Nuclear Information System (INIS)

    Thompson, K.M.

    1991-01-01

    The US Department of Energy (DOE), US Environmental Protection Agency (EPA), and the Washington State Department of Ecology (Ecology) have negotiated a strategy for performing Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) and Resource Conservation and Recovery Act (RCRA) Past Practice investigations in a more streamlined manner with a bias-for-action. This strategy provides new concepts for (1) accelerating decision-making by maximizing the use of existing data consistent with data quality objectives and (2) undertaking expedited response actions and/or interim remedial measures as appropriate to either remove threats to human health and welfare and the environment or to reduce risk by reducing toxicity, mobility or volume of contaminants. Since the goal of the program is cleanup, much more emphasis will be placed on initiating and completing waste site cleanups through interim measures. While investigations and studies are important in meeting long-range goals, there is now agreement by the parties that an appropriate and significant portion of the near-term funding resources can and should be dedicated to remedial work, where there is sufficient information from which to plan and implement interim remedial measures. The initial stages of Hanford clean-up will optimize the use of interim cleanup actions when justified and practicable. Existing data will be evaluated as the initial basis for decision-making. If the data are found to be insufficient, additional essential data will be collected to support the IRM in a limited field investigation (LFI). Only data needed to formulate a conceptual model (source to pathway to receptor) and qualitative risk assessment would be obtained. The data quality objectives of the LFI will be established based on the use of the data in deciding on IRMs

  10. Determination of site-specific glycan heterogeneity on glycoproteins

    DEFF Research Database (Denmark)

    Kolarich, Daniel; Jensen, Pia Hønnerup; Altmann, Friedrich

    2012-01-01

    and the determination of site-specific glycan heterogeneity. The described workflow takes approximately 3-5 d, including sample preparation and data analysis. The data obtained from analyzing released glycans of rHuEPO and IgG, described in the second protocol of this series (10.1038/nprot.2012.063), provide...

  11. A distance measurement between specific sites on the cytoplasmic surface of bovine rhodopsin in rod outer segment disk membranes.

    Science.gov (United States)

    Albert, A D; Watts, A; Spooner, P; Groebner, G; Young, J; Yeagle, P L

    1997-08-14

    Structural information on mammalian integral membrane proteins is scarce. As part of work on an alternative approach to the structure of bovine rhodopsin, a method was devised to obtain an intramolecular distance between two specific sites on rhodopsin while in the rod outer segment disk membrane. In this report, the distance between the rhodopsin kinase phosphorylation site(s) on the carboxyl terminal and the top of the third transmembrane helix was measured on native rhodopsin. Rhodopsin was labeled with a nuclear spin label (31P) by limited phosphorylation with rhodopsin kinase. Major phosphorylation occurs at serines 343 and 338 on the carboxyl terminal. The phosphorylated rhodopsin was then specifically labeled on cysteine 140 with an electron spin label. Magic angle spinning 31P-nuclear magnetic resonance revealed the resonance arising from the phosphorylated protein. The enhancement of the transverse relaxation of this resonance by the paramagnetic spin label was observed. The strength of this perturbation was used to determine the through-space distance between the phosphorylation site(s) and the spin label position. A distance of 18 +/- 3 A was obtained.

  12. Assessing Contractor Capabilities for Streamlined Site Investigations

    Science.gov (United States)

    The purpose of this document is to familiarize and encourage brownfields decision makers to investigate and employ innovative methods for characterizing their sites, to assist brownfields decision makers in assessing contractors' capabilities.

  13. Corrective Action Investigation Plan for Corrective Action Unit 567: Miscellaneous Soil Sites, Nevada National Security Site, Nevada, with ROTC 1 Revision 0

    Energy Technology Data Exchange (ETDEWEB)

    Matthews, Patrick K.

    2013-07-01

    at Atmospheric Test Site T-1 exceeds the final action level (FAL) and requires corrective action. The presence and nature of contamination outside the default contamination boundary at Atmospheric Test Site T-1 and all other CAU 567 CASs will be evaluated based on information collected from a field investigation. Radiological contamination will be evaluated based on a comparison of the TED at sample locations to the dose-based FAL. The TED will be calculated as the total of separate estimates of internal and external dose. Results from the analysis of soil samples will be used to calculate internal radiological dose. Thermoluminescent dosimeters placed at the center of each sample location will be used to measure external radiological dose. Appendix A provides a detailed discussion of the DQO methodology and the DQOs specific to each CAS.

  14. Environmental Management Waste Management Facility (EMWMF) Site-Specific Health and Safety Plan, Oak Ridge, Tennessee

    Energy Technology Data Exchange (ETDEWEB)

    Flynn, N.C. Bechtel Jacobs

    2008-04-21

    The Bechtel Jacobs Company LLC (BJC) policy is to provide a safe and healthy workplace for all employees and subcontractors. The implementation of this policy requires that operations of the Environmental Management Waste Management Facility (EMWMF), located one-half mile west of the U.S. Department of Energy (DOE) Y-12 National Security Complex, be guided by an overall plan and consistent proactive approach to environment, safety and health (ES&H) issues. The BJC governing document for worker safety and health, BJC/OR-1745, 'Worker Safety and Health Program', describes the key elements of the BJC Safety and Industrial Hygiene (IH) programs, which includes the requirement for development and implementation of a site-specific Health and Safety Plan (HASP) where required by regulation (refer also to BJC-EH-1012, 'Development and Approval of Safety and Health Plans'). BJC/OR-1745, 'Worker Safety and Health Program', implements the requirements for worker protection contained in Title 10 Code of Federal Regulations (CFR) Part 851. The EMWMF site-specific HASP requirements identifies safe operating procedures, work controls, personal protective equipment, roles and responsibilities, potential site hazards and control measures, site access requirements, frequency and types of monitoring, site work areas, decontamination procedures, and outlines emergency response actions. This HASP will be available on site for use by all workers, management and supervisors, oversight personnel and visitors. All EMWMF assigned personnel will be briefed on the contents of this HASP and will be required to follow the procedures and protocols as specified. The policies and procedures referenced in this HASP apply to all EMWMF operations activities. In addition the HASP establishes ES&H criteria for the day-to-day activities to prevent or minimize any adverse effect on the environment and personnel safety and health and to meet standards that define acceptable

  15. Site-Specific Difference of Bone Geometry Indices in Hypoparathyroid Patients

    Directory of Open Access Journals (Sweden)

    Hye-Sun Park

    2017-02-01

    Full Text Available BackgroundHypoparathyroid patients often have a higher bone mineral density (BMD than the general population. However, an increase in BMD does not necessarily correlate with a solid bone microstructure. This study aimed to evaluate the bone microstructure of hypoparathyroid patients by using hip structure analysis (HSA.MethodsNinety-five hypoparathyroid patients >20 years old were enrolled and 31 of them had eligible data for analyzing bone geometry parameters using HSA. And among the control data, we extracted sex-, age-, and body mass index-matched three control subjects to each patient. The BMD data were reviewed retrospectively and the bone geometry parameters of the patients were analyzed by HSA.ResultsThe mean Z-scores of hypoparathyroid patients at the lumbar spine, femoral neck, and total hip were above zero (0.63±1.17, 0.48±1.13, and 0.62±1.10, respectively. The differences in bone geometric parameters were site specific. At the femoral neck and intertrochanter, the cross-sectional area (CSA and cortical thickness (C.th were higher, whereas the buckling ratio (BR was lower than in controls. However, those trends were opposite at the femoral shaft; that is, the CSA and C.th were low and the BR was high.ConclusionOur study shows the site-specific effects of hypoparathyroidism on the bone. Differences in bone components, marrow composition, or modeling based bone formation may explain these findings. However, further studies are warranted to investigate the mechanism, and its relation to fracture risk.

  16. Site investigations for repositories for solid radioactive wastes in shallow ground

    International Nuclear Information System (INIS)

    1982-01-01

    This report provides an overview and technical guidelines for investigations on a national level for the selection and confirmation of a repository site that will provide adequately safe performance for disposal of solid radioactive wastes that are low- or intermediate-level and short-lived. It also provides basic information on technical activities to be undertaken and on techniques that are available for such investigations in the various steps in selecting suitable sites. The report supplements the information given in Shallow Ground Disposal of Radioactive Wastes: A Guidebook, IAEA Safety Series No. 53 (1981). This report focuses mainly on different aspects of earth sciences and the various investigative techniques relative to earth sciences that may be necessary for site investigations. Some major related studies in other fields are discussed briefly. It is assumed that no previous investigations have been undertaken, and the report proceeds through area site selection to the stage when the site is confirmed as suitable for a waste repository

  17. Site investigations for repositories for solid radioactive wastes in shallow ground

    Energy Technology Data Exchange (ETDEWEB)

    1982-01-01

    This report provides an overview and technical guidelines for investigations on a national level for the selection and confirmation of a repository site that will provide adequately safe performance for disposal of solid radioactive wastes that are low- or intermediate-level and short-lived. It also provides basic information on technical activities to be undertaken and on techniques that are available for such investigations in the various steps in selecting suitable sites. The report supplements the information given in Shallow Ground Disposal of Radioactive Wastes: A Guidebook, IAEA Safety Series No. 53 (1981). This report focuses mainly on different aspects of earth sciences and the various investigative techniques relative to earth sciences that may be necessary for site investigations. Some major related studies in other fields are discussed briefly. It is assumed that no previous investigations have been undertaken, and the report proceeds through area site selection to the stage when the site is confirmed as suitable for a waste repository.

  18. Discovery of Nigri/nox and Panto/pox site-specific recombinase systems facilitates advanced genome engineering.

    Science.gov (United States)

    Karimova, Madina; Splith, Victoria; Karpinski, Janet; Pisabarro, M Teresa; Buchholz, Frank

    2016-07-22

    Precise genome engineering is instrumental for biomedical research and holds great promise for future therapeutic applications. Site-specific recombinases (SSRs) are valuable tools for genome engineering due to their exceptional ability to mediate precise excision, integration and inversion of genomic DNA in living systems. The ever-increasing complexity of genome manipulations and the desire to understand the DNA-binding specificity of these enzymes are driving efforts to identify novel SSR systems with unique properties. Here, we describe two novel tyrosine site-specific recombination systems designated Nigri/nox and Panto/pox. Nigri originates from Vibrio nigripulchritudo (plasmid VIBNI_pA) and recombines its target site nox with high efficiency and high target-site selectivity, without recombining target sites of the well established SSRs Cre, Dre, Vika and VCre. Panto, derived from Pantoea sp. aB, is less specific and in addition to its native target site, pox also recombines the target site for Dre recombinase, called rox. This relaxed specificity allowed the identification of residues that are involved in target site selectivity, thereby advancing our understanding of how SSRs recognize their respective DNA targets.

  19. Site specific plan. [Environmental Restoration and Waste Management, Savannah River Site

    Energy Technology Data Exchange (ETDEWEB)

    Hutchison, J.; Jernigan, G.

    1989-12-01

    The Environmental Restoration and Waste Management Five-Year Plan (FYP) covers the period for FY 1989 through FY 1995. The plan establishes a Department of Energy -- Headquarters (DOE-HQ) agenda for cleanup and compliance against which overall progress can be measured. The FYP covers three areas: Corrective Activities, Environmental Restoration, and Waste Management Operations. Corrective Activities are those activities necessary to bring active or standby facilities into compliance with local, state, and federal environmental regulations. Environmental restoration activities include the assessment and cleanup of surplus facilities and inactive waste sites. Waste management operations includes the treatment, storage, and disposal of wastes which are generated as a result of ongoing operations. This Site Specific Plan (SSP) has been prepared by the Savannah River Site (SRS) in order to show how environmental restoration and waste management activities that were identified during the preparation of the FYP will be implemented, tracked, and reported. The SSP describes DOE Savannah River (DOE-SR) and operating contractor, Westinghouse Savannah River Company (WSRC), organizations that are responsible, for undertaking the activities identified in this plan. The SSP has been prepared in accordance with guidance received from DOE-HQ. DOE-SR is accountable to DOE-HQ for the implementation of this plan. 8 refs., 46 figs., 23 tabs.

  20. ROAD REPAIR WORKS ON THE MEYRIN SITE

    CERN Multimedia

    ST-TFM Group

    2001-01-01

    ST Division will proceed, as from Monday 23 July, in repairing some parts of roads on the Meyrin site (see drawing). This work will last for one week depending on the weather conditions and will cause some traffic hold ups during this period. Please follow the indications on the temporary road signs. Thanking you in advance for your comprehension.

  1. Site specific mineral composition and microstructure of human supra-gingival dental calculus.

    Science.gov (United States)

    Hayashizaki, Junko; Ban, Seiji; Nakagaki, Haruo; Okumura, Akihiko; Yoshii, Saori; Robinson, Colin

    2008-02-01

    Dental calculus has been implicated in the aetiology of several periodontal conditions. Its prevention and removal are therefore desirable clinical goals. While it is known that calculus is very variable in chemical composition, crystallinity and crystallite size little is known about site specific variability within a dentition and between individuals. With this in mind, a study was undertaken to investigate the comparative site specific nature and composition of human dental supra-gingival dental calculus obtained from 66 male patients visiting for their dental check-up using fluorescent X-ray spectroscopy, X-ray diffractometry and Fourier transform infrared spectroscopy. The supra-gingival dental calculus formed on the lingual surfaces of lower anterior teeth and the buccal surfaces of upper molar teeth were classified into four types based on calcium phosphate phases present. There was significant difference in composition of the crystal phase types between lower and upper teeth (pdental calculus on anterior or molar teeth of all samples. The degree of crystallinity of dental calculus formed on the upper molar teeth was higher than that formed on the lower anterior teeth (pdental calculus formed on the lower anterior teeth were higher than on upper molar teeth (pdental supra-gingival dental calculus is related to its location in the mouth.

  2. Site-specific DNA transesterification catalyzed by a restriction enzyme

    OpenAIRE

    Sasnauskas, Giedrius; Connolly, Bernard A.; Halford, Stephen E.; Siksnys, Virginijus

    2007-01-01

    Most restriction endonucleases use Mg2+ to hydrolyze phosphodiester bonds at specific DNA sites. We show here that BfiI, a metal-independent restriction enzyme from the phospholipase D superfamily, catalyzes both DNA hydrolysis and transesterification reactions at its recognition site. In the presence of alcohols such as ethanol or glycerol, it attaches the alcohol covalently to the 5′ terminus of the cleaved DNA. Under certain conditions, the terminal 3′-OH of one DNA strand can attack the t...

  3. Site-specific induction of nuclear anomalies (apoptotic bodies and micronuclei) by carcinogens in mice

    International Nuclear Information System (INIS)

    Ronen, A.; Heddle, J.A.

    1984-01-01

    The usefulness of nuclear anomalies (NA) as a short-term test for indication of carcinogens in the mouse colon has been suggested previously by experiments in which colon-specific carcinogens induced NA in the colon, whereas non-colon carcinogens were, in general, impotent in that organ. We have extended this work to other sites in the digestive tract of female C57BL/6 mice treated with gamma-rays, 1,2-dimethylhydrazine dihydrochloride, or N-methylnitrosourea. Each agent induced NA at all of the sites examined. The frequency of NA at different times after treatment depended upon both the agent used and the site examined. 1,2-Dimethylhydrazine dihydrochloride (which is known to induce tumors predominantly in the colon) induces NA with the highest efficiency (relative to gamma-rays) in the descending colon. N-Methylnitrosourea (which induces tumors mainly in the forestomach) induces NA with the highest efficiency in the forestomach. These results further support the usefulness of the assay in that the frequency of NA produced at the various sites by 1,2-dimethylhydrazine dihydrochloride and N-methylnitrosourea correlates with that found in the carcinogenicity studies

  4. Site-Specific Modification Using the 2′-Methoxyethyl Group Improves the Specificity and Activity of siRNAs

    Directory of Open Access Journals (Sweden)

    Xinyun Song

    2017-12-01

    Full Text Available Rapid progress has been made toward small interfering RNA (siRNA-based therapy for human disorders, but rationally optimizing siRNAs for high specificity and potent silencing remains a challenge. In this study, we explored the effect of chemical modification at the cleavage site of siRNAs. We found that modifications at positions 9 and 10 markedly reduced the silencing potency of the unmodified strand of siRNAs but were well tolerated by the modified strand. Intriguingly, addition of the 2′-methoxyethyl (MOE group at the cleavage site improved both the specificity and silencing activity of siRNAs by facilitating the oriented RNA-induced silencing complex (RISC loading of the modified strand. Furthermore, we combined MOE modifications at positions 9 and 10 of one strand together with 2′-O-methylation (OMe at position 14 of the other strand and found a synergistic effect that improved the specificity of siRNAs. The surprisingly beneficial effect of the combined modification was validated using siRNA-targeting endogenous gene intercellular adhesion molecule 1 (ICAM1. We found that the combined modifications eliminated its off-target effects. In conclusion, we established effective strategies to optimize siRNAs using site-specific MOE modifications. The findings may allow the creation of superior siRNAs for therapy in terms of activity and specificity.

  5. AECL strategy for surface-based investigations of potential disposal sites and the development of a geosphere model for a site

    International Nuclear Information System (INIS)

    Whitaker, S.H.; Brown, A.; Davison, C.C.; Gascoyne, M.; Lodha, G.S.; Stevenson, D.R.; Thorne, G.A.; Tomsons, D.

    1994-05-01

    The objective of this report is to summarize AECL's strategy for surface-based geotechnical site investigations used in screening and evaluating candidate areas and candidate sites for a nuclear fuel waste repository and for the development of geosphere models of sites. The report is one of several prepared by national nuclear fuel waste management programs for the Swedish Nuclear Fuel and Waste Management Co. (SKB) to provide international background on site investigations for SKB's R and D programme on siting.The scope of the report is limited to surface-based investigations of the geosphere, those done at surface or in boreholes drilled from surface. The report discusses AECL's investigation strategy and the methods proposed for use in surface-based reconnaissance and detailed site investigations at potential repository sites. Site investigations done for AECL's Underground Research Laboratory are used to illustrate the approach. The report also discusses AECL's strategy for developing conceptual and mathematical models of geological conditions at sites and the use of these models in developing a model (Geosphere Model) for use in assessing the performance of the disposal system after a repository is closed. Models based on the site data obtained at the URL are used to illustrate the approach. Finally, the report summarizes the lessons learned from AECL's R and D program on site investigations and mentions some recent developments in the R and D program. 120 refs, 33 figs, 7 tabs

  6. AECL strategy for surface-based investigations of potential disposal sites and the development of a geosphere model for a site

    Energy Technology Data Exchange (ETDEWEB)

    Whitaker, S H; Brown, A; Davison, C C; Gascoyne, M; Lodha, G S; Stevenson, D R; Thorne, G A; Tomsons, D [AECL Research, Whiteshell Labs., Pinawa, MB (Canada)

    1994-05-01

    The objective of this report is to summarize AECL`s strategy for surface-based geotechnical site investigations used in screening and evaluating candidate areas and candidate sites for a nuclear fuel waste repository and for the development of geosphere models of sites. The report is one of several prepared by national nuclear fuel waste management programs for the Swedish Nuclear Fuel and Waste Management Co. (SKB) to provide international background on site investigations for SKB`s R and D programme on siting.The scope of the report is limited to surface-based investigations of the geosphere, those done at surface or in boreholes drilled from surface. The report discusses AECL`s investigation strategy and the methods proposed for use in surface-based reconnaissance and detailed site investigations at potential repository sites. Site investigations done for AECL`s Underground Research Laboratory are used to illustrate the approach. The report also discusses AECL`s strategy for developing conceptual and mathematical models of geological conditions at sites and the use of these models in developing a model (Geosphere Model) for use in assessing the performance of the disposal system after a repository is closed. Models based on the site data obtained at the URL are used to illustrate the approach. Finally, the report summarizes the lessons learned from AECL`s R and D program on site investigations and mentions some recent developments in the R and D program. 120 refs, 33 figs, 7 tabs.

  7. GPS 2.1: enhanced prediction of kinase-specific phosphorylation sites with an algorithm of motif length selection.

    Science.gov (United States)

    Xue, Yu; Liu, Zexian; Cao, Jun; Ma, Qian; Gao, Xinjiao; Wang, Qingqi; Jin, Changjiang; Zhou, Yanhong; Wen, Longping; Ren, Jian

    2011-03-01

    As the most important post-translational modification of proteins, phosphorylation plays essential roles in all aspects of biological processes. Besides experimental approaches, computational prediction of phosphorylated proteins with their kinase-specific phosphorylation sites has also emerged as a popular strategy, for its low-cost, fast-speed and convenience. In this work, we developed a kinase-specific phosphorylation sites predictor of GPS 2.1 (Group-based Prediction System), with a novel but simple approach of motif length selection (MLS). By this approach, the robustness of the prediction system was greatly improved. All algorithms in GPS old versions were also reserved and integrated in GPS 2.1. The online service and local packages of GPS 2.1 were implemented in JAVA 1.5 (J2SE 5.0) and freely available for academic researches at: http://gps.biocuckoo.org.

  8. Corrective Action Investigation Plan for Corrective Action Unit 366: Area 11 Plutonium Valley Dispersion Sites, Nevada National Security Site, Nevada

    International Nuclear Information System (INIS)

    Matthews, Patrick

    2011-01-01

    associated with the nuclear tests, it was determined that CASs 11-23-02, 11-23-03, and 11-23-04 will be investigated as one release site. The three test areas associated with these CASs are in close proximity; the devices tested were all composed of plutonium and enriched uranium; and the ground zeroes are all posted high contamination areas (HCAs). Because the device tested at CAS 11-23-01 was composed primarily of enriched uranium and the ground zero is not a posted HCA, the CAS will be investigated as a separate release. The DQO process also resulted in an assumption that TED within the HCAs and contaminated waste dumps exceeds the FAL and requires corrective action. A field investigation will be performed to define where TED exceeds the FAL and to determine whether other contaminants of concern are present at the site associated with other activities that took place at the site or from spills or waste discovered during the investigation. The presence and nature of contamination from other types of releases (such as migration and any potential releases discovered during the investigation) will be evaluated using soil samples collected from the locations most likely containing contamination, if present. Appendix A provides a detailed discussion of the DQO methodology and the DQOs specific to each CAS.

  9. Work plan addendum for David Witherspoon, Inc., 901 Site Building Characterization, Knoxville, Tennessee

    International Nuclear Information System (INIS)

    1997-01-01

    This building characterization plan was developed as an addendum to the existing site characterization work plan documents, which are in Appendix B of the David Witherspoon, Inc., (DWI) preliminary remedial investigation (RI)/feasibility study (FS). All building characterization activities will be conducted in accordance with the rules of the Hazardous Substance Remedial Action Program under the direction of the Tennessee Department of Environment and Conservation, Division of Superfund (TN Rules 1200-1-3) and its implementing regulations. Additional rules of the state of Tennessee, Comprehensive Environmental Response, Compensation, and Liability Act of 1980, and the U.S. Environmental Protection Agency guidance were consulted during development of this plan. Activities at the DWI site were concerned with scrap metal processing and scrap metal resale

  10. Generalized theory on the mechanism of site-specific DNA-protein interactions

    Science.gov (United States)

    Niranjani, G.; Murugan, R.

    2016-05-01

    We develop a generalized theoretical framework on the binding of transcription factor proteins (TFs) with specific sites on DNA that takes into account the interplay of various factors regarding overall electrostatic potential at the DNA-protein interface, occurrence of kinetic traps along the DNA sequence, presence of other roadblock protein molecules along DNA and crowded environment, conformational fluctuations in the DNA binding domains (DBDs) of TFs, and the conformational state of the DNA. Starting from a Smolochowski type theoretical framework on site-specific binding of TFs we logically build our model by adding the effects of these factors one by one. Our generalized two-step model suggests that the electrostatic attractive forces present inbetween the positively charged DBDs of TFs and the negatively charged phosphate backbone of DNA, along with the counteracting shielding effects of solvent ions, is the core factor that creates a fluidic type environment at the DNA-protein interface. This in turn facilitates various one-dimensional diffusion (1Dd) processes such as sliding, hopping and intersegmental transfers. These facilitating processes as well as flipping dynamics of conformational states of DBDs of TFs between stationary and mobile states can enhance the 1Dd coefficient on a par with three-dimensional diffusion (3Dd). The random coil conformation of DNA also plays critical roles in enhancing the site-specific association rate. The extent of enhancement over the 3Dd controlled rate seems to be directly proportional to the maximum possible 1Dd length. We show that the overall site-specific binding rate scales with the length of DNA in an asymptotic way. For relaxed DNA, the specific binding rate will be independent of the length of DNA as length increases towards infinity. For condensed DNA as in in vivo conditions, the specific binding rate depends on the length of DNA in a turnover way with a maximum. This maximum rate seems to scale with the

  11. Forsmark site investigation. Bedrock geology - overview and excursion guide

    Energy Technology Data Exchange (ETDEWEB)

    Stephens, Michael B. (Geological Survey of Sweden, Uppsala (Sweden))

    2010-09-15

    Bearing in mind the significance of the bedrock data from the ground surface for the geological 3D modelling work, SKB decided to present excursion guides that serve in the demonstration of the bedrock geology at the ground surface in both the Forsmark (this guide) and Laxemar-Simpevarp areas. An excursion guide is also available for the Olkiluoto area in south-western Finland, which has been selected for the construction of a repository for the disposal of highly radioactive, spent nuclear fuel in Finland. The current excursion guide presents the bedrock geology and describes in detail the character of the bedrock at ten representative outcrops or outcrop areas at the ground surface in the site investigation area at Forsmark. All localities are located within or immediately adjacent to the proposed repository volume selected by SKB

  12. Oskarshamn site investigation. Bedrock geology - overview and excursion guide

    Energy Technology Data Exchange (ETDEWEB)

    Wahlgren, Carl-Henric (Geological Survey of Sweden, Uppsala (Sweden))

    2010-09-15

    Bearing in mind the significance of the bedrock data from the ground surface for the geological 3D modelling work, SKB decided to present excursion guides that serve in the demonstration of the bedrock geology at the ground surface in both the Forsmark and Laxemar-Simpevarp (this guide) areas. An excursion guide is also available for the Olkiluoto area in south-western Finland, which has been selected for the construction of a repository for the disposal of highly radioactive, spent nuclear fuel. The current excursion guide presents the bedrock geology and describes in detail the character of the bedrock at eight representative outcrops or outcrop areas at the ground surface in the site investigation area at Laxemar-Simpevarp and at one locality north of this area, i.e. at a total of nine localities

  13. Oskarshamn site investigation. Bedrock geology - overview and excursion guide

    International Nuclear Information System (INIS)

    Wahlgren, Carl-Henric

    2010-09-01

    Bearing in mind the significance of the bedrock data from the ground surface for the geological 3D modelling work, SKB decided to present excursion guides that serve in the demonstration of the bedrock geology at the ground surface in both the Forsmark and Laxemar-Simpevarp (this guide) areas. An excursion guide is also available for the Olkiluoto area in south-western Finland, which has been selected for the construction of a repository for the disposal of highly radioactive, spent nuclear fuel. The current excursion guide presents the bedrock geology and describes in detail the character of the bedrock at eight representative outcrops or outcrop areas at the ground surface in the site investigation area at Laxemar-Simpevarp and at one locality north of this area, i.e. at a total of nine localities

  14. Forsmark site investigation. Bedrock geology - overview and excursion guide

    International Nuclear Information System (INIS)

    Stephens, Michael B.

    2010-09-01

    Bearing in mind the significance of the bedrock data from the ground surface for the geological 3D modelling work, SKB decided to present excursion guides that serve in the demonstration of the bedrock geology at the ground surface in both the Forsmark (this guide) and Laxemar-Simpevarp areas. An excursion guide is also available for the Olkiluoto area in south-western Finland, which has been selected for the construction of a repository for the disposal of highly radioactive, spent nuclear fuel in Finland. The current excursion guide presents the bedrock geology and describes in detail the character of the bedrock at ten representative outcrops or outcrop areas at the ground surface in the site investigation area at Forsmark. All localities are located within or immediately adjacent to the proposed repository volume selected by SKB

  15. US DoE's Environmental Management Site-Specific Advisory Board 15 Years of Community Involvement

    International Nuclear Information System (INIS)

    Nielson, M.; Brennan, C.A.

    2009-01-01

    This paper provides an overview of the U.S. Department of Energy's Environmental Management Site-Specific Advisory Board (EM SSAB) from its roots in the early 1990's at the Keystone Center to its current activities. The EM SSAB has a unique mandate to provide input regarding the cleanup of nuclear legacy sites in the United States. Chartered under the Federal Advisory Committee Act, the EM SSAB today comprises eight local boards. The Office of Environmental Management has made public participation a fundamental component of its cleanup mission and has found that the EM SSAB has contributed greatly to bringing community values and priorities to the cleanup decision-making processes. Public participation that involves ongoing community engagement has inherent challenges; the EM SSAB has additional challenges that reflect the political and technical nature of the Agency's work. (authors)

  16. Ecosystem description of a drainage area - a strategy in biosphere descriptions during site investigations for a repository of spent nuclear fuel

    International Nuclear Information System (INIS)

    Lindborg, T.; Lofgren, A.

    2004-01-01

    During the next few years the Swedish Nuclear Fuel and Waste Management Co. (SKB) performs site investigations at two sites in Sweden for a future repository of spent nuclear fuel. Novel methods based on systems and landscape ecology are developed to understand and model the radionuclide flow in the biosphere using site specific data for a safety assessment. This work describes the strategy for development of a descriptive ecosystem model for the surface ecosystem. The site description is needed to: a) perform a safety assessment that describes and analyzes different scenarios for radionuclide releases into the ecosystem and possible pathways for dispersal or accumulation radionuclides in the ecosystem, b) detect changes caused by the construction of a repository, c) establish a baseline for detecting long-term effects of the repository. The description adopts a site-specific approach focusing on the quantification of the properties that will constitute the descriptive model. The aim is also to present the methodology for determining the properties, to describe the development of the framework for the descriptive ecosystem models by integrating use of different properties, and finally, to present vital data from other site descriptive models such as those for geology or hydrogeology. The safety assessment will use an approach, among other methods, where transport and accumulation of radionuclides will be modelled by quantifying biogeochemical pathways of matter. The descriptive ecosystem model applied to the site was therefore built to describe and quantify processes affecting i.e. turnover of matter in a drainage area. The conclusions from applying this approach was that by have estimating the flow of matter the ecological and physical constrains on the system reduces the potential variations in outcome of future states of the ecosystem and thus also reduces the uncertainties in estimating radionuclide flow and consequences to humans and the environment. (author)

  17. Savannah River Site`s Site Specific Plan. Environmental restoration and waste management, fiscal year 1992

    Energy Technology Data Exchange (ETDEWEB)

    1991-08-01

    This Site Specific Plan (SSP) has been prepared by the Savannah River Site (SRS) in order to show the Environmental Restoration and Waste Management activities that were identified during the preparation of the Department of Energy-Headquarters (DOE-HQ) Environmental Restoration and Waste Management Five-Year Plan (FYP) for FY 1992--1996. The SSP has been prepared in accordance with guidance received from DOE-HQ. DOE-SR is accountable to DOE-HQ for the implementation of this plan. The purpose of the SSP is to develop a baseline for policy, budget, and schedules for the DOE Environmental Restoration and Waste Management activities. The plan explains accomplishments since the Fiscal Year (FY) 1990 plan, demonstrates how present and future activities are prioritized, identifies currently funded activities and activities that are planned to be funded in the upcoming fiscal year, and describes future activities that SRS is considering.

  18. Environmental transportation of tritium and estimation of site-specific model parameters for Kaiga site, India.

    Science.gov (United States)

    Reji, T K; Ravi, P M; Ajith, T L; Dileep, B N; Hegde, A G; Sarkar, P K

    2012-04-01

    Tritium content in air moisture, soil water, rain water and plant water samples collected around the Kaiga site, India was estimated and the scavenging ratio, wet deposition velocity and ratio of specific activities of tritium between soil water and air moisture were calculated and the results are interpreted. Scavenging ratio was found to vary from 0.06 to 1.04 with a mean of 0.46. The wet deposition velocity of tritium observed in the present study was in the range of 3.3E-03 to 1.1E-02 m s(-1) with a mean of 6.6E-03 m s(-1). The ratio of specific activity of tritium in soil moisture to that in air moisture ranged from 0.17 to 0.95 with a mean of 0.49. The specific activity of tritium in plant water in this study varied from 73 to 310 Bq l(-1). The present study is very useful for understanding the process and modelling of transfer of tritium through air/soil/plant system at the Kaiga site.

  19. Facilitating Site Specific and Citizens Advisory Boards: Running Effective Meetings that Involve Complex Technical Issues

    International Nuclear Information System (INIS)

    Freeman, J.

    2009-01-01

    Environmental cleanup issues at federal sites are more often than not on the agendas of meetings of the Site Specific Advisory Boards (SSABs), also called Citizens Advisory Boards (CABs), that exist at most U.S. Department of Energy (DOE) sites with an Environmental Management (EM) mission. In 1994, when Congress established these committees comprised of local citizens, it enabled community stakeholders to become more directly involved in DOE EM cleanup decisions. This involvement is to help the agency make cost-effective and environmentally sound decisions which lead to faster, safer cleanups. Eight local Boards that fall under the Federal Advisory Committee Act-chartered EM SSAB charter are found in Hanford, Washington; Idaho; Northern New Mexico; Nevada; Oak Ridge, Tennessee; Paducah, Kentucky; Portsmouth, Ohio; and at the Savannah River Site in South Carolina. These boards provide advice and recommendations about EM site-specific issues such as cleanup standards (how clean is clean?), environmental restoration, waste management, the stabilization and disposal of non-stockpile nuclear materials, future land use and long-term stewardship, risk assessment and management, and cleanup science and technology activities. These issues are, by their very nature, loaded with complicated technical terms and strategies, scientific data and interpretations, and long histories of studies and reports. The members of SSABs and CABs rotate on and off the Boards according to defined terms of office, thereby routinely opening the Boards' ranks to new members, many of whom are new to the issues. In addition, members of the public who have access to public comment periods at each Board meeting run up against the same daunting menu of obscure acronyms, scientific terms and notations, and an historical trail which is not always evident except to those involved with the issues over many years. How does a facilitator effectively guide such a group of citizens, each of whom arrives to

  20. Site-specific data confirm arsenic exposure predicted by the U.S. Environmental Protection Agency.

    OpenAIRE

    Walker, S; Griffin, S

    1998-01-01

    The EPA uses an exposure assessment model to estimate daily intake to chemicals of potential concern. At the Anaconda Superfund site in Montana, the EPA exposure assessment model was used to predict total and speciated urinary arsenic concentrations. Predicted concentrations were then compared to concentrations measured in children living near the site. When site-specific information on concentrations of arsenic in soil, interior dust, and diet, site-specific ingestion rates, and arsenic abso...

  1. Development of the web-based site investigation flow diagram in repository development program

    International Nuclear Information System (INIS)

    Yamamoto, Shuichi; Yoshimura, Kimitaka; Ohuchi, Jin; Tsuboya, Takao; Ando, Kenichi

    2005-01-01

    In siting a repository for high level radioactive wastes (HLW), it is essential for consensus building intelligibly and visually present why and how the area is selected as a suitable site. However 'information asymmetry' exists especially between society and an implementation body because various types of investigation, analysis and assessment are implemented in site characterization on the basis of a wide variety of advanced science and technology. Communication between experts (e.g. surveyors and modelers) is also important for efficient and reliable site investigation/ characterization. The Web-based Site Investigation Flow Diagram (SIFD) has been developed as a tool for information sharing among stake holders and society-jointed decision making. To test applicability of the SIFD, virtual site characterization ('dry run') is performed using the existing site investigation data. It is concluded that the web-based SIFD enhance traceability and transparency of the site investigation/ characterization, and therefore it would be a powerful communication tool among experts for efficient and reliable site investigation/characterization and among stake holders for consensus building

  2. Site-Specific Multilevel Modeling of Potato Response to Nitrogen Fertilization

    Directory of Open Access Journals (Sweden)

    Serge-Étienne Parent

    2017-12-01

    Full Text Available Technologies of precision agriculture, digital soil maps, and meteorological stations provide a minimum data set to guide precision farming operations. However, determining optimal nutrient requirements for potato (Solanum tuberosum L. crops at subfield scale remains a challenge given specific climatic, edaphic, and managerial conditions. Multilevel modeling can generalize yield response to fertilizer additions using data easily accessible to growers. Our objective was to elaborate a multilevel N fertilizer response model for potato crops using the Mitscherlich equation and a core data set of 93 N fertilizer trials conducted in Québec, Canada. Daily climatic data were collected at 10 × 10 km resolution. Soils were characterized by organic matter content, pH, and texture in the arable layer, and by texture and tools of pedometrics across a gleization-podzolization continuum in subsoil layers. There were five categories of preceding crops and five cultivar maturity orders. The three Mitscherlich parameters (Asymptote, Rate, and Environment were most often site-specific. Sensitivity analysis showed that optimum N dosage increased with non-leguminous high-residue preceding crops, coarser soils, podzolization, drier climatic condition, and late cultivar maturity. The inferential model could guide site-specific N fertilization using an accessible minimum data set to support fertilization decisions. As decision-support system, the model could also provide a range of optimum N doses across a large spectrum of site-specific conditions including climate change.

  3. Team and Project Work in Engineering Practices

    Directory of Open Access Journals (Sweden)

    Anders Buch

    2015-11-01

    Full Text Available In this article, we investigate teamwork amongst professionals in engineering consultancy companies in order to discern how teamwork affects the collaboration and work practices of the professionals. The article investigates how professional engineering practices are enacted in two engineering consultancy companies in Denmark where teamwork has been or is an ideal for organizing work. Through a practice-based lens, the article sets out to investigate, firstly, how discourses about team and project work affect engineering work practices; secondly, how technologymediated management is reconciled in teamwork practices; and thirdly, how team and project work affect engineering professionalism and collaborative work practices. A practice theoretical framework informs the analysis. Teamwork is investigated as a phenomenon enacted through the sayings, doings and relatings of practitioners in landscapes of practices and the interconnectedness of the practices is traced through the setup of specific ecologies in the sites.

  4. Evaluation of potential water conservation using site-specific irrigation

    Science.gov (United States)

    With the advent of site-specific variable-rate irrigation (VRI) systems, irrigation can be spatially managed within sub-field-sized zones. Spatial irrigation management can optimize spatial water use efficiency and may conserve water. Spatial VRI systems are currently being managed by consultants ...

  5. Site investigation - equipment for geological, geophysical, hydrogeological and hydrochemical characterization

    International Nuclear Information System (INIS)

    Almen, K.E.; Fridh, B.; Johansson, B.E.; Sehlstedt, M.

    1986-11-01

    The investigations are performed within a site investigation program. In total about 60,000 m of cored 56 mm boreholes have been drilled and investigated at eight study sites. A summarized description of the main investigation methods is included. Instruments for geophysical investigations contains equipment for ground measurements as well as for borehole logging. The Geophysical investigations including the borehole radar measurements, are indirect methods for the geological and hydrogeological characterization of the rock formation. Great effort has been laid on the development of hydrogeological instruments for hydraulic tests and groundwater head measurements. In order to obtain hydrochemical investigations with high quality, a complete system for sampling and analysis of ground water has been developed. (orig./PW)

  6. Draft Level 1 Remedial Investigation Work Plan: 316-3 waste disposal trenches

    International Nuclear Information System (INIS)

    1987-09-01

    This work plan describes the work to be performed for the initial level of site characterization for the 316.3 Trenches at the Hanford Site. This initial site characterization effort will include a review of existing environmental contamination data for the 300 Area as well as collection and analysis of environmental samples to better characterize subsurface contamination at the site. 7 refs., 10 figs., 7 tabs

  7. High-Affinity Quasi-Specific Sites in the Genome: How the DNA-Binding Proteins Cope with Them

    Science.gov (United States)

    Chakrabarti, J.; Chandra, Navin; Raha, Paromita; Roy, Siddhartha

    2011-01-01

    Many prokaryotic transcription factors home in on one or a few target sites in the presence of a huge number of nonspecific sites. Our analysis of λ-repressor in the Escherichia coli genome based on single basepair substitution experiments shows the presence of hundreds of sites having binding energy within 3 Kcal/mole of the OR1 binding energy, and thousands of sites with binding energy above the nonspecific binding energy. The effect of such sites on DNA-based processes has not been fully explored. The presence of such sites dramatically lowers the occupation probability of the specific site far more than if the genome were composed of nonspecific sites only. Our Brownian dynamics studies show that the presence of quasi-specific sites results in very significant kinetic effects as well. In contrast to λ-repressor, the E. coli genome has orders of magnitude lower quasi-specific sites for GalR, an integral transcription factor, thus causing little competition for the specific site. We propose that GalR and perhaps repressors of the same family have evolved binding modes that lead to much smaller numbers of quasi-specific sites to remove the untoward effects of genomic DNA. PMID:21889449

  8. LHRH-pituitary plasma membrane binding: the presence of specific binding sites in other tissues.

    Science.gov (United States)

    Marshall, J C; Shakespear, R A; Odell, W D

    1976-11-01

    Two specific binding sites for LHRH are present on plasma membranes prepared from rat and bovine anterior pituitary glands. One site is of high affinity (K = 2X108 1/MOL) and the second is of lower affinity (8-5X105 1/mol) and much greater capacity. Studies on membrane fractions prepared from other tissues showed the presence of a single specific site for LHRH. The kinetics and specificity of this site were similar to those of the lower affinity pituitary receptor. These results indicate that only pituitary membranes possess the higher affinity binding site and suggest that the low affinity site is not of physiological importance in the regulation of gonadotrophin secretion. After dissociation from membranes of non-pituitary tissues 125I-LHRH rebound to pituitary membrane preparations. Thus receptor binding per se does not result in degradation of LHRH and the function of these peripheral receptors remains obscure.

  9. Forsmark site investigation. Interpretation of topographic lineaments 2002

    International Nuclear Information System (INIS)

    Isaksson, Hans

    2003-04-01

    SKB performs site investigations for localization of a deep repository for high level radioactive waste. The site investigations are performed in two municipalities; Oesthammar and Oskarshamn. The Forsmark investigation area is situated in Oesthammar, close to the Forsmark nuclear power plant. The purpose of interpretation of lineaments from topographic data is to identify linear features (lineaments), which may correspond to deformation zones in the bedrock. The data will be combined with interpretations of lineaments from airborne geophysical data in order to produce an integrated lineament interpretation for the Forsmark area. This integrated interpretation will be combined with geological data in order to establish a bedrock geological map of the Forsmark area. The area for the lineament interpretation is the same as that selected for the bedrock mapping activities during 2002, i.e. the land area around Forsmark

  10. Medical Geography and Topography Works: the first environmental studies in a specific city

    Directory of Open Access Journals (Sweden)

    Angela Lúcia de Araújo Ferreira

    2012-02-01

    Full Text Available The natural environment and the geographical circumstances set the basis for the development of an hygiene-oriented thinking and led physicians to investigate and diagnose the regional and urban space between the eighteenth and twentieth centuries. These ideas were systematically compiled in works known as Medical Geography and Topography Works which, when known throughout the world, ended up becoming precise descriptions of the cities' territory, providing a spatial account of diseases and identifying their nature, evolution and treatment. Besides recovering the origin of these treaties and stressing their importance as amongst the first "geographical" investigations of urban space, this work aims to include Brazil, and specifically the city of Natal (in northeast Brazil within the context of these analyses, with special emphasis on the work entitled Topography of Natal and its Medical Geography authored by doctor Januário Cicco in 1920.

  11. Draft Site Management and Monitoring Plan for Corpus Christi Maintenance and New Work Ocean Dredged Material Disposal Site

    Science.gov (United States)

    USEPA Region 6 and the US Army Corps of Engineers submit for public comment the Draft Site Management and Monitoring Plan for Corpus Christi Maintenance and New Work Ocean Dredged Material Disposal Site

  12. Element-specific and constant parameters used for dose calculations in SR-Site

    International Nuclear Information System (INIS)

    Norden, Sara; Avila, Rodolfo; De la Cruz, Idalmis; Stenberg, Kristofer; Grolander, Sara

    2010-12-01

    The report presents Best Estimate (BE) values and Probability Distribution Functions (PDFs) of Concentration Ratios (CR) for different types of terrestrial and aquatic biota and distribution coefficients (K d ) for organic and inorganic deposits, as well as for suspended matter in freshwater and marine ecosystems. The BE values have been used in deterministic simulations for derivation of Landscape Dose Factors (LDF) applied for dose assessments in SR-Site. The PDFs have been used in probabilistic simulations for uncertainty and sensitivity analysis of the LDFs. The derivation of LDFs for SR-Site is described in /Avila et al. 2010/. The CR and K d values have been derived using both site-specific data measured at Laxemar and Forsmark during the site investigation program and literature data. These two data sources have been combined using Bayesian updating methods, which are described in detail in an Appendix, along with the input data used in the statistical analyses and the results obtained. The report also describes a kinetic-allometric model that was applied for deriving values of CR for terrestrial herbivores in cases when site and literature data for an element were missing. In addition, the report presents values for a number of other parameters used in the SR-Site Radionuclide Model for the biosphere: radionuclide decay-ingrowth data, elemental diffusivities, fractions of element content released during decomposition processes, ingestion of food, water and soil by cattle, elements retention fraction on plant surfaces during irrigation. The report also presents parameter values used in calculation of doses to a reference man: dose coefficients for inhalation, ingestion and external exposure, inhalation rates, ingestion rates of food and water

  13. Element-specific and constant parameters used for dose calculations in SR-Site

    Energy Technology Data Exchange (ETDEWEB)

    Norden, Sara (Svensk Kaernbraenslehantering AB (Sweden)); Avila, Rodolfo; De la Cruz, Idalmis; Stenberg, Kristofer; Grolander, Sara (Facilia AB (Sweden))

    2010-12-15

    The report presents Best Estimate (BE) values and Probability Distribution Functions (PDFs) of Concentration Ratios (CR) for different types of terrestrial and aquatic biota and distribution coefficients (K{sub d}) for organic and inorganic deposits, as well as for suspended matter in freshwater and marine ecosystems. The BE values have been used in deterministic simulations for derivation of Landscape Dose Factors (LDF) applied for dose assessments in SR-Site. The PDFs have been used in probabilistic simulations for uncertainty and sensitivity analysis of the LDFs. The derivation of LDFs for SR-Site is described in /Avila et al. 2010/. The CR and K{sub d} values have been derived using both site-specific data measured at Laxemar and Forsmark during the site investigation program and literature data. These two data sources have been combined using Bayesian updating methods, which are described in detail in an Appendix, along with the input data used in the statistical analyses and the results obtained. The report also describes a kinetic-allometric model that was applied for deriving values of CR for terrestrial herbivores in cases when site and literature data for an element were missing. In addition, the report presents values for a number of other parameters used in the SR-Site Radionuclide Model for the biosphere: radionuclide decay-ingrowth data, elemental diffusivities, fractions of element content released during decomposition processes, ingestion of food, water and soil by cattle, elements retention fraction on plant surfaces during irrigation. The report also presents parameter values used in calculation of doses to a reference man: dose coefficients for inhalation, ingestion and external exposure, inhalation rates, ingestion rates of food and water

  14. Corrective Action Investigation Plan for Corrective Action Unit 166: Storage Yards and Contaminated Materials, Nevada Test Site, Nevada

    International Nuclear Information System (INIS)

    David Strand

    2006-01-01

    Corrective Action Unit 166 is located in Areas 2, 3, 5, and 18 of the Nevada Test Site, which is 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit (CAU) 166 is comprised of the seven Corrective Action Sites (CASs) listed below: (1) 02-42-01, Cond. Release Storage Yd - North; (2) 02-42-02, Cond. Release Storage Yd - South; (3) 02-99-10, D-38 Storage Area; (4) 03-42-01, Conditional Release Storage Yard; (5) 05-19-02, Contaminated Soil and Drum; (6) 18-01-01, Aboveground Storage Tank; and (7) 18-99-03, Wax Piles/Oil Stain. These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives. Additional information will be obtained by conducting a corrective action investigation (CAI) before evaluating corrective action alternatives and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the Corrective Action Decision Document. The sites will be investigated based on the data quality objectives (DQOs) developed on February 28, 2006, by representatives of the Nevada Division of Environmental Protection; U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office; Stoller-Navarro Joint Venture; and Bechtel Nevada. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 166. Appendix A provides a detailed discussion of the DQO methodology and the DQOs specific to each CAS. The scope of the CAI for CAU 166 includes the following activities: (1) Move surface debris and/or materials, as needed, to facilitate sampling. (2) Conduct radiological surveys. (3) Perform field screening. (4) Collect and submit environmental samples for laboratory analysis to determine if

  15. Remedial Action Plan and site design for stabilization of the inactive uranium mill tailings site at Durango, Colorado: Attachment 2, Geology report

    International Nuclear Information System (INIS)

    1991-12-01

    Detailed investigations of geologic, geomorphic, and seismic conditions at the Bodo Canyon disposal site were conducted. The purpose of these investigations was basic site characterization and identification of potential geologic hazards that could affect long-term site stability. Subsequent engineering studies, such as analyses of hydrologic and liquefaction hazards, used the data developed in these studies. The geomorphic analysis was employed in the design of effective erosion protection. Studies of the regional and local seismotectonic setting, which included a detailed search for possible capable faults within a 65 kilometer radius of the site, provided the basis for seismic design parameters. The scope of work performed included the following: Compilation and analysis of previous published and unpublished geologic literature and maps; Review of historical and instrumental earthquake data; Review of site-specific subsurface geologic data, including lithologic and geophysical logs of exploratory boreholes advanced in the site area; Photogeologic interpretations of existing conventional aerial photographs; and, Ground reconnaissance and mapping of the site region

  16. Position specific variation in the rate of evolution intranscription factor binding sites

    Energy Technology Data Exchange (ETDEWEB)

    Moses, Alan M.; Chiang, Derek Y.; Kellis, Manolis; Lander, EricS.; Eisen, Michael B.

    2003-08-28

    The binding sites of sequence specific transcription factors are an important and relatively well-understood class of functional non-coding DNAs. Although a wide variety of experimental and computational methods have been developed to characterize transcription factor binding sites, they remain difficult to identify. Comparison of non-coding DNA from related species has shown considerable promise in identifying these functional non-coding sequences, even though relatively little is known about their evolution. Here we analyze the genome sequences of the budding yeasts Saccharomyces cerevisiae, S. bayanus, S. paradoxus and S. mikataeto study the evolution of transcription factor binding sites. As expected, we find that both experimentally characterized and computationally predicted binding sites evolve slower than surrounding sequence, consistent with the hypothesis that they are under purifying selection. We also observe position-specific variation in the rate of evolution within binding sites. We find that the position-specific rate of evolution is positively correlated with degeneracy among binding sites within S. cerevisiae. We test theoretical predictions for the rate of evolution at positions where the base frequencies deviate from background due to purifying selection and find reasonable agreement with the observed rates of evolution. Finally, we show how the evolutionary characteristics of real binding motifs can be used to distinguish them from artifacts of computational motif finding algorithms. As has been observed for protein sequences, the rate of evolution in transcription factor binding sites varies with position, suggesting that some regions are under stronger functional constraint than others. This variation likely reflects the varying importance of different positions in the formation of the protein-DNA complex. The characterization of the pattern of evolution in known binding sites will likely contribute to the effective use of comparative

  17. Salmon Site Remedial Investigation Report, Appendix B (Part 2)

    International Nuclear Information System (INIS)

    1999-01-01

    This Salmon Site Remedial Investigation Report provides the results of activities initiated by the U.S. Department of Energy (DOE) to determine if contamination at the Salmon Site poses a current or future risk to human health and the environment. These results were used to develop and evaluate a range of risk-based remedial alternatives. Located in Lamar County, Mississippi, the Salmon Site was used by the U.S. Atomic Energy Commission (predecessor to the DOE) between 1964 and 1970 for two nuclear and two gas explosions conducted deep underground in a salt dome. The testing resulted in the release of radionuclides into the salt dome. During reentry drilling and other site activities, liquid and solid wastes containing radioactivity were generated resulting in surface soil and groundwater contamination. Most of the waste and contaminated soil and water were disposed of in 1993 during site restoration either in the cavities left by the tests or in an injection well. Other radioactive wastes were transported to the Nevada Test Site for disposal. Nonradioactive wastes were disposed of in pits at the site and capped with clean soil and graded. The preliminary investigation showed residual contamination in the Surface Ground Zero mud pits below the water table. Remedial investigations results concluded the contaminant concentrations detected present no significant risk to existing and/or future land users, if surface institutional controls and subsurface restrictions are maintained. Recent sampling results determined no significant contamination in the surface or shallow subsurface. The test cavity resulting from the experiments is contaminated and cannot be economically remediated with existing technologies. The ecological sampling did not detect biological uptake of contaminants in the plants or animals sampled. Based on the current use of the Salmon Site, the following remedial actions were identified to protect both human health and the environment: (1) the

  18. Salmon Site Remedial Investigation Report, Appendix B (Part 1)

    International Nuclear Information System (INIS)

    1999-01-01

    This Salmon Site Remedial Investigation Report provides the results of activities initiated by the U.S. Department of Energy (DOE) to determine if contamination at the Salmon Site poses a current or future risk to human health and the environment. These results were used to develop and evaluate a range of risk-based remedial alternatives. Located in Lamar County, Mississippi, the Salmon Site was used by the U.S. Atomic Energy Commission (predecessor to the DOE) between 1964 and 1970 for two nuclear and two gas explosions conducted deep underground in a salt dome. The testing resulted in the release of radionuclides into the salt dome. During reentry drilling and other site activities, liquid and solid wastes containing radioactivity were generated resulting in surface soil and groundwater contamination. Most of the waste and contaminated soil and water were disposed of in 1993 during site restoration either in the cavities left by the tests or in an injection well. Other radioactive wastes were transported to the Nevada Test Site for disposal. Nonradioactive wastes were disposed of in pits at the site and capped with clean soil and graded. The preliminary investigation showed residual contamination in the Surface Ground Zero mud pits below the water table. Remedial investigations results concluded the contaminant concentrations detected present no significant risk to existing and/or future land users, if surface institutional controls and subsurface restrictions are maintained. Recent sampling results determined no significant contamination in the surface or shallow subsurface. The test cavity resulting from the experiments is contaminated and cannot be economically remediated with existing technologies. The ecological sampling did not detect biological uptake of contaminants in the plants or animals sampled. Based on the current use of the Salmon Site, the following remedial actions were identified to protect both human health and the environment: (1) the

  19. Preliminary site investigation for LL and IL radwaste disposal for Qinshan NPP

    International Nuclear Information System (INIS)

    Huang Yawen; Chen Zhangru

    1993-01-01

    With the purpose of selecting a disposal site for the low- and intermediate-level radwastes arising from Qinshan NPP, site investigations were carried out in several districts of Zhejiang Province. Investigation objectives included the circumstances of geology, hydrogeology, environmental ecology, and social economy. On the basis of collected data, five possible sites were recommended for policy-making reference and further investigation

  20. 30 CFR 46.11 - Site-specific hazard awareness training.

    Science.gov (United States)

    2010-07-01

    ... Section 46.11 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR EDUCATION AND... workers; (4) Customers, including commercial over-the-road truck drivers; (5) Construction workers or... procedures. The training must address site-specific health and safety risks, such as unique geologic or...

  1. Corrective Action Investigation Plan for Corrective Action Unit 139: Waste Disposal Sites, Nevada Test Site, Nevada

    International Nuclear Information System (INIS)

    Grant Evenson

    2006-01-01

    Corrective Action Unit (CAU) 139 is located in Areas 3, 4, 6, and 9 of the Nevada Test Site, which is 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 139 is comprised of the seven corrective action sites (CASs) listed below: (1) 03-35-01, Burn Pit; (2) 04-08-02, Waste Disposal Site; (3) 04-99-01, Contaminated Surface Debris; (4) 06-19-02, Waste Disposal Site/Burn Pit; (5) 06-19-03, Waste Disposal Trenches; (6) 09-23-01, Area 9 Gravel Gertie; and (7) 09-34-01, Underground Detection Station. These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives with the exception of CASs 09-23-01 and 09-34-01. Regarding these two CASs, CAS 09-23-01 is a gravel gertie where a zero-yield test was conducted with all contamination confined to below ground within the area of the structure, and CAS 09-34-01 is an underground detection station where no contaminants are present. Additional information will be obtained by conducting a corrective action investigation (CAI) before evaluating corrective action alternatives and selecting the appropriate corrective action for the other five CASs where information is insufficient. The results of the field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the Corrective Action Decision Document. The sites will be investigated based on the data quality objectives (DQOs) developed on January 4, 2006, by representatives of the Nevada Division of Environmental Protection; U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office; Stoller-Navarro Joint Venture; and Bechtel Nevada. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 139

  2. Site-specific identification of heparan and chondroitin sulfate glycosaminoglycans in hybrid proteoglycans.

    Science.gov (United States)

    Noborn, Fredrik; Gomez Toledo, Alejandro; Green, Anders; Nasir, Waqas; Sihlbom, Carina; Nilsson, Jonas; Larson, Göran

    2016-10-03

    Heparan sulfate (HS) and chondroitin sulfate (CS) are complex polysaccharides that regulate important biological pathways in virtually all metazoan organisms. The polysaccharides often display opposite effects on cell functions with HS and CS structural motifs presenting unique binding sites for specific ligands. Still, the mechanisms by which glycan biosynthesis generates complex HS and CS polysaccharides required for the regulation of mammalian physiology remain elusive. Here we present a glycoproteomic approach that identifies and differentiates between HS and CS attachment sites and provides identity to the core proteins. Glycopeptides were prepared from perlecan, a complex proteoglycan known to be substituted with both HS and CS chains, further digested with heparinase or chondroitinase ABC to reduce the HS and CS chain lengths respectively, and thereafter analyzed by nLC-MS/MS. This protocol enabled the identification of three consensus HS sites and one hybrid site, carrying either a HS or a CS chain. Inspection of the amino acid sequence at the hybrid attachment locus indicates that certain peptide motifs may encode for the chain type selection process. This analytical approach will become useful when addressing fundamental questions in basic biology specifically in elucidating the functional roles of site-specific glycosylations of proteoglycans.

  3. Improving Site-Specific Radiological Performance Assessments - 13431

    Energy Technology Data Exchange (ETDEWEB)

    Tauxe, John; Black, Paul; Catlett, Kate; Lee, Robert; Perona, Ralph; Stockton, Tom; Sully, Mike [Neptune and Company, Inc., Los Alamos, New Mexico 87544 (United States)

    2013-07-01

    An improved approach is presented for conducting complete and defensible radiological site-specific performance assessments (PAs) to support radioactive waste disposal decisions. The basic tenets of PA were initiated some thirty years ago, focusing on geologic disposals and evaluating compliance with regulations. Some of these regulations were inherently probabilistic (i.e., addressing uncertainty in a quantitative fashion), such as the containment requirements of the U.S. Environmental Protection Agency's (EPA's) 40 CFR 191, Environmental Radiation Protection Standards for Management and Disposal of Spent Nuclear Fuel, High-Level and Transuranic Radioactive Wastes, Chap. 191.13 [1]. Methods of analysis were developed to meet those requirements, but at their core early PAs used 'conservative' parameter values and modeling approaches. This limited the utility of such PAs to compliance evaluation, and did little to inform decisions about optimizing disposal, closure and long-term monitoring and maintenance, or, in general, maintaining doses 'as low as reasonably achievable' (ALARA). This basic approach to PA development in the United States was employed essentially unchanged through the end of the 20. century, principally by the U.S. Department of Energy (DOE). Performance assessments developed in support of private radioactive waste disposal operations, regulated by the U.S. Nuclear Regulatory Commission (NRC) and its agreement states, were typically not as sophisticated. Discussion of new approaches to PA is timely, since at the time of this writing, the DOE is in the midst of revising its Order 435.1, Radioactive Waste Management [2], and the NRC is revising 10 CFR 61, Licensing Requirements for Land Disposal of Radioactive Waste [3]. Over the previous decade, theoretical developments and improved computational technology have provided the foundation for integrating decision analysis (DA) concepts and objective-focused thinking, plus

  4. Improving Site-Specific Radiological Performance Assessments - 13431

    International Nuclear Information System (INIS)

    Tauxe, John; Black, Paul; Catlett, Kate; Lee, Robert; Perona, Ralph; Stockton, Tom; Sully, Mike

    2013-01-01

    An improved approach is presented for conducting complete and defensible radiological site-specific performance assessments (PAs) to support radioactive waste disposal decisions. The basic tenets of PA were initiated some thirty years ago, focusing on geologic disposals and evaluating compliance with regulations. Some of these regulations were inherently probabilistic (i.e., addressing uncertainty in a quantitative fashion), such as the containment requirements of the U.S. Environmental Protection Agency's (EPA's) 40 CFR 191, Environmental Radiation Protection Standards for Management and Disposal of Spent Nuclear Fuel, High-Level and Transuranic Radioactive Wastes, Chap. 191.13 [1]. Methods of analysis were developed to meet those requirements, but at their core early PAs used 'conservative' parameter values and modeling approaches. This limited the utility of such PAs to compliance evaluation, and did little to inform decisions about optimizing disposal, closure and long-term monitoring and maintenance, or, in general, maintaining doses 'as low as reasonably achievable' (ALARA). This basic approach to PA development in the United States was employed essentially unchanged through the end of the 20. century, principally by the U.S. Department of Energy (DOE). Performance assessments developed in support of private radioactive waste disposal operations, regulated by the U.S. Nuclear Regulatory Commission (NRC) and its agreement states, were typically not as sophisticated. Discussion of new approaches to PA is timely, since at the time of this writing, the DOE is in the midst of revising its Order 435.1, Radioactive Waste Management [2], and the NRC is revising 10 CFR 61, Licensing Requirements for Land Disposal of Radioactive Waste [3]. Over the previous decade, theoretical developments and improved computational technology have provided the foundation for integrating decision analysis (DA) concepts and objective-focused thinking, plus a Bayesian approach to

  5. Site-specific variability of loess and palaeosols (Ruma, Vojvodina, northern Serbia)

    NARCIS (Netherlands)

    Vandenberghe, J.; Markovic, S.B.; Jovanovic, M.; Hambach, U.

    2013-01-01

    The study of temporal variations in soil intensity has mostly been limited to specific sites. However, it is important for correctly interpreting the stratigraphy and palaeoclimatic significance of loess and palaeosols series to understand the reasons for the spatial variability. More specifically,

  6. The Human Splicing Factor ASF/SF2 can Specifically Recognize Pre-mRNA 5' Splice Sites

    Science.gov (United States)

    Zuo, Ping; Manley, James L.

    1994-04-01

    ASF/SF2 is a human protein previously shown to function in in vitro pre-mRNA splicing as an essential factor necessary for all splices and also as an alternative splicing factor, capable of switching selection of 5' splice sites. To begin to study the protein's mechanism of action, we have investigated the RNA binding properties of purified recombinant ASF/SF2. Using UV crosslinking and gel shift assays, we demonstrate that the RNA binding region of ASF/SF2 can interact with RNA in a sequence-specific manner, recognizing the 5' splice site in each of two different pre-mRNAs. Point mutations in the 5' splice site consensus can reduce binding by as much as a factor of 100, with the largest effects observed in competition assays. These findings support a model in which ASF/SF2 aids in the recognition of pre-mRNA 5' splice sites.

  7. Appreciating "Thirdspace": An Alternative Way of Viewing and Valuing Site-Specific Dance Performance

    Science.gov (United States)

    Munjee, Tara

    2014-01-01

    Site-specific dance performance involves the presentation of choreography in connection with a site. The context of the site combined with a viewer's personal history, beliefs, and identity impact the reading and appreciation of the performance. Although both stage and site dance performance valuing elicit multiple interpretations of artistic…

  8. Site-specific and multielement approach to the determination of liquid-vapor isotope fractionation parameters. The case of alcohols

    International Nuclear Information System (INIS)

    Moussa, I.; Naulet, N.; Martin, M.L.; Martin, G.J.

    1990-01-01

    Isotope fractionation phenomena occurring at the natural abundance level in the course of liquid-vapor transformation have been investigated by using the SNIF-NMR method (site-specific natural isotope fractionation studied by NMR) which has a unique capability of providing simultaneous access to fractionation parameters associated with different molecular isotopomers. This new approach has been combined with the determination of overall carbon and hydrogen fractionation effects by isotope ratio mass spectrometry (IRMS). The results of distillation and evaporation experiments of alcohols performed in technical conditions of practical interest have been analyzed according to the Rayleigh-type model. In order to check the performance of the column, unit fractionation factors were measured beforehand for water and for the hydroxylic sites of methanol and ethanol for which liquid-vapor equilibrium constants were already known. Inverse isotope effects are determined in distillation experiments for the overall carbon isotope ratio and for the site-specific hydrogen isotope ratios associated with the methyl and methylene sites of methanol and ethanol. In contrast, normal isotope effects are produced by distillation for the hydroxylic sites and by evaporation for all the isotopic ratios

  9. A Molecular Toolbox to Engineer Site-Specific DNA Replication Perturbation.

    Science.gov (United States)

    Larsen, Nicolai B; Hickson, Ian D; Mankouri, Hocine W

    2018-01-01

    Site-specific arrest of DNA replication is a useful tool for analyzing cellular responses to DNA replication perturbation. The E. coli Tus-Ter replication barrier can be reconstituted in eukaryotic cells as a system to engineer an unscheduled collision between a replication fork and an "alien" impediment to DNA replication. To further develop this system as a versatile tool, we describe a set of reagents and a detailed protocol that can be used to engineer Tus-Ter barriers into any locus in the budding yeast genome. Because the Tus-Ter complex is a bipartite system with intrinsic DNA replication-blocking activity, the reagents and protocols developed and validated in yeast could also be optimized to engineer site-specific replication fork barriers into other eukaryotic cell types.

  10. A Molecular Toolbox to Engineer Site-Specific DNA Replication Perturbation

    DEFF Research Database (Denmark)

    Larsen, Nicolai B; Hickson, Ian D; Mankouri, Hocine W

    2018-01-01

    " impediment to DNA replication. To further develop this system as a versatile tool, we describe a set of reagents and a detailed protocol that can be used to engineer Tus-Ter barriers into any locus in the budding yeast genome. Because the Tus-Ter complex is a bipartite system with intrinsic DNA replication......Site-specific arrest of DNA replication is a useful tool for analyzing cellular responses to DNA replication perturbation. The E. coli Tus-Ter replication barrier can be reconstituted in eukaryotic cells as a system to engineer an unscheduled collision between a replication fork and an "alien......-blocking activity, the reagents and protocols developed and validated in yeast could also be optimized to engineer site-specific replication fork barriers into other eukaryotic cell types....

  11. Preliminary data report of investigations conducted at the Salmon Site, Lamar County, Mississippi

    International Nuclear Information System (INIS)

    1994-04-01

    The US Department of Energy (DOE) conducted ecological studies at the Salmon Site (SS), Lamar County, Mississippi, from the middle of June 1992 to the end of April 1993. The studies are part of the Remedial Investigation and Feasibility Study (RI/FS) being conducted by the DOE. The RI/FS is the methodology under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980, as amended by the Superfund Amendments and Reauthorization Act of 1986 (CERCLA/SARA) for evaluating hazardous waste sites on the National Priorities List (NPL). The Salmon Site is not listed on the NPL but DOE has voluntarily elected to conduct the evaluation of the SS in accordance with CERCLA/SARA. As part of the remedial investigation, baseline human health and ecological risk assessments will be conducted. These baseline risk assessments will evaluate the potential impact on human health and the environment if remedial actions are not conducted, identify locations where additional information needs to be collected, help determine whether remedial actions are necessary, and provide justification for performing remedial actions. This report describes the sampling activities conducted between February and April 1993 to aid in evaluating the possible environmental impacts at the SS tailored to the specific circumstances and conditions found there. The initial investigations included identification of the flora and fauna in and around the SS, with particular emphasis on identifying sensitive environments, endangered species and their habitats, and those species consumed by humans or found in human food chains

  12. Work characteristics predict the development of multi-site musculoskeletal pain

    NARCIS (Netherlands)

    Oakman, J.; Wind, A. de; Heuvel, S.G. van den; Beek, A.J. van der

    2017-01-01

    Purpose. Musculoskeletal pain in more than one body region is common and a barrier to sustaining employment. We aimed to examine whether work characteristics predict the development of multi-site pain (MSP), and to determine differences in work-related predictors between age groups. Methods. This

  13. Versatile and Efficient Site-Specific Protein Functionalization by Tubulin Tyrosine Ligase.

    Science.gov (United States)

    Schumacher, Dominik; Helma, Jonas; Mann, Florian A; Pichler, Garwin; Natale, Francesco; Krause, Eberhard; Cardoso, M Cristina; Hackenberger, Christian P R; Leonhardt, Heinrich

    2015-11-09

    A novel chemoenzymatic approach for simple and fast site-specific protein labeling is reported. Recombinant tubulin tyrosine ligase (TTL) was repurposed to attach various unnatural tyrosine derivatives as small bioorthogonal handles to proteins containing a short tubulin-derived recognition sequence (Tub-tag). This novel strategy enables a broad range of high-yielding and fast chemoselective C-terminal protein modifications on isolated proteins or in cell lysates for applications in biochemistry, cell biology, and beyond, as demonstrated by the site-specific labeling of nanobodies, GFP, and ubiquitin. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. Specifications in early conceptual design work

    DEFF Research Database (Denmark)

    Hansen, Claus Thorp; Andreasen, Mogens Myrup

    2007-01-01

    In early conceptual design the design team is working in an uncertain situation, where the understanding of a need is limited and not much is known about the solution space. In this situation the design team has to both analyse need and explore solution space. Thus, the team has to formulate design...... specifications, which express attractive product goals, and has to synthesise the product idea. The authors of this paper see a challenge to enhance and improve our understanding of the nature of design specifications as a means to support the synthesis of a product idea. In this empirical study we analyse...... the structure and content of design specifications during early ideation activities, where initial design specifications are formulated and a product idea is synthesised. We have analysed specification documents of 19 teams of novice designers. Our analysis indicates that a productive product design...

  15. Detection of site specific glycosylation in proteins using flow cytometry†

    Science.gov (United States)

    Jayakumar, Deepak; Marathe, Dhananjay D.; Neelamegham, Sriram

    2009-01-01

    We tested the possibility that it is possible to express unique peptide probes on cell surfaces and detect site-specific glycosylation on these peptides using flow cytometry. Such development can enhance the application of flow cytometry to detect and quantify post-translational modifications in proteins. To this end, the N-terminal section of the human leukocyte glycoprotein PSGL-1 (P-selectin glycoprotein ligand-1) was modified to contain a poly-histidine tag followed by a proteolytic cleavage site. Amino acids preceding the cleavage site have a single O-linked glycosylation site. The recombinant protein called PSGL-1 (HT) was expressed on the surface of two mammalian cell lines, CHO and HL-60, using a lentiviral delivery approach. Results demonstrate that the N-terminal portion of PSGL-1 (HT) can be released from these cells by protease, and the resulting peptide can be readily captured and detected using cytometry-bead assays. Using this strategy, the peptide was immunoprecipitated onto beads bearing mAbs against either the poly-histidine sequence or the human PSGL-1. The carbohydrate epitope associated with the released peptide was detected using HECA-452 and CSLEX-1, monoclonal antibodies that recognize the sialyl Lewis-X epitope. Finally, the peptide released from cells could be separated and enriched using nickel chelate beads. Overall, such an approach that combines recombinant protein expression with flow cytometry, may be useful to quantify changes in site-specific glycosylation for basic science and clinical applications. PMID:19735085

  16. Investigating the loss of work productivity due to symptomatic leiomyoma.

    Science.gov (United States)

    Hasselrot, Klara; Lindeberg, Mia; Konings, Peter; Kopp Kallner, Helena

    2018-01-01

    Leiomyoma affects up to 50% of fertile women, leading to morbidity such as bleeding or pain. The effect of symptomatic leiomyoma on the productivity of employed women is understudied. The present study investigates productivity loss in a Swedish setting in women with symptomatic leiomyoma compared to healthy women. Women seeking care for leiomyoma and heavy menstrual bleeding (HMB) were recruited at nine Swedish sites. Healthy controls with self-perceived mild to normal menstruation were recruited at routine visits. Cases and controls were employed without option to work from home. After recruitment, all women reported the work productivity and activity impairment (WPAI) questionnaire, the pictorial blood assessment chart (PBAC) and pain on the visual analog scale (VAS). Women with symptomatic leiomyoma (n = 88) missed more working time during menses compared to asymptomatic controls (n = 34): 7.6 vs 0.2% p = 0.003. The proportion of impairment while working was also significantly higher in women with symptomatic leiomyoma (43.8 vs 12.1% p100). Symptomatic leiomyoma leads to loss of working hours as well as loss of productivity during working hours, and affects women in other daily activities. Increased awareness of the impact of leiomyomas on women's lives is needed, and timely and appropriate management of the symptomatic leiomyomas could improve work productivity and quality of life.

  17. 40 CFR 228.6 - Specific criteria for site selection.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Specific criteria for site selection. 228.6 Section 228.6 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN..., nursery, feeding, or passage areas of living resources in adult or -juvenile phases; (3) Location in...

  18. Site-specific effects of the nonsteroidal anti-inflammatory drug lysine clonixinate on rat brain opioid receptors.

    Science.gov (United States)

    Ortí, E; Coirini, H; Pico, J C

    1999-04-01

    In addition to effects in the periphery through inhibition of prostaglandin synthesis, several lines of evidence suggest that nonsteroidal anti-inflammatory drugs (NSAIDs) act in the central nervous system. The possibility that the central action of NSAIDs involves regulation of opioid receptors was investigated by quantitative autoradiography of mu, delta, and kappa sites in rat brain slices. Increased (p lysine clonixinate. Labeling of delta receptors was lower in the lateral septum, and kappa sites decreased in thalamic nuclei. These effects were not mediated through direct interaction with opioid-binding sites, since receptor-binding assays using rat brain membranes confirmed that clonixinate up to 1 x 10(-4) mol/l does not inhibit mu, delta, and kappa receptor specific binding. Central effects of NSAIDs might, therefore, involve interaction with the opioid receptor system through indirect mechanisms.

  19. Work-related determinants of multi-site musculoskeletal pain among employees in the health care sector.

    Science.gov (United States)

    Neupane, Subas; Nygård, Clas-Håkan; Oakman, Jodi

    2016-06-16

    Work-related musculoskeletal pain is a major occupational problem. Those with pain in multiple sites usually report worse health outcomes than those with pain in one site. This study explored prevalence and associated predictors of multi-site pain in health care sector employees. Survey responses from 1348 health care sector employees across three organisations (37% response rate) collected data on job satisfaction, work life balance, psychosocial and physical hazards, general health and work ability. Musculoskeletal discomfort was measured across 5 body regions with pain in ≥ 2 sites defined as multi-site pain. Generalized linear models were used to identify relationships between work-related factors and multi-site pain. Over 52% of the employees reported pain in multiple body sites and 19% reported pain in one site. Poor work life balance (PRR = 2.33, 95% CI = 1.06-5.14). physical (PRR = 7.58, 95% CI = 4.89-11.77) and psychosocial (PRR = 1.59, 95% CI = 1.00-2.57) hazard variables were related to multi-site pain (after controlling for age, gender, health and work ability. Older employees and females were more likely to report multi-site pain. Effective risk management of work related multi-site pain must include identification and control of psychosocial and physical hazards.

  20. PART I: Bioventing Pilot Test Work Plan for Fire Protection Training Area Site FY-03, Charleston AFB, South Carolina. PART II: Draft Interim Pilot Test Results Report for Fire Protection Training Area Site FT-03, Charleston AFB, South Carolina

    National Research Council Canada - National Science Library

    1993-01-01

    This site-specific work plan presents the scope of a bioventing pilot test for in situ treatment of fuel contaminated soils at the Fire Protection Training Area designated as Site FT-O3, Charleston Air Force Base (AFB), South Carolina...

  1. Road repair works on the Meyrin site

    CERN Multimedia

    2003-01-01

    ST Division will proceed, as from Monday 15th of September, in repairing some parts of roads on the Meyrin site (see drawing). This work will last for three weeks depending on the weather conditions and will cause some traffic hold ups during this period. Please follow the indications on the temporary road signs. Thanking you in advance for your comprehension. ST-CE and ST-FM Groups GSM 160224 - 163976

  2. Site-specific calibration of the Hanford personnel neutron dosimeter

    International Nuclear Information System (INIS)

    Endres, A.W.; Brackenbush, L.W.; Baumgartner, W.V.; Rathbone, B.A.

    1994-10-01

    A new personnel dosimetry system, employing a standard Hanford thermoluminescent dosimeter (TLD) and a combination dosimeter with both CR-39 nuclear track and TLD-albedo elements, is being implemented at Hanford. Measurements were made in workplace environments in order to verify the accuracy of the system and establish site-specific factors to account for the differences in dosimeter response between the workplace and calibration laboratory. Neutron measurements were performed using sources at Hanford's Plutonium Finishing Plant under high-scatter conditions to calibrate the new neutron dosimeter design to site-specific neutron spectra. The dosimeter was also calibrated using bare and moderated 252 Cf sources under low-scatter conditions available in the Hanford Calibration Laboratory. Dose equivalent rates in the workplace were calculated from spectrometer measurements using tissue equivalent proportional counter (TEPC) and multisphere spectrometers. The accuracy of the spectrometers was verified by measurements on neutron sources with calibrations directly traceable to the National Institute of Standards and Technology (NIST)

  3. Biologic overview for the Nevada Nuclear Waste Storage Investigations, Nevada Test Site, Nye County, Nevada

    International Nuclear Information System (INIS)

    Collins, E.; O'Farrell, T.P.; Rhoads, W.A.

    1982-01-01

    The Nevada Nuclear Waste Storage Investigations project study area includes five major vegetation associations characteristic of the transition between the northern extent of the Mojave Desert and the southern extent of the Great Basin Desert. A total of 32 species of reptiles, 66 species of birds, and 46 species of mammals are known to occur within these associations elsewhere on the Nevada Test Site. Ten species of plants, and the mule deer, wild horse, feral burro, and desert tortoise were defined as possible sensitive species because they are protected by federal and state regulations, or are being considered for such protection. The major agricultural resources of southern Nye County included 737,000 acres of public grazing land managed by the Bureau of Land Management, and 9500 acres of irrigated crop land located in the Beatty/Oasis valleys, the Amargosa Valley, and Ash Meadows. Range lands are of poor quality. Alfalfa and cotton are the major crops along with small amounts of grains, Sudan grass, turf, fruits, and melons. The largest impacts to known ecosystems are expected to result from: extensive disturbances associated with construction of roads, seismic lines, drilling pads, and surface facilities; storage and leaching of mined spoils; disposal of water; off-road vehicle travel; and, over several hundred years, elevated soil temperatures. Significant impacts to off-site areas such as Ash Meadows are anticipated if new residential developments are built there to accommodate an increased work force. Several species of concern and their essential habitats are located at Ash Meadows. Available literature contained sufficient baseline information to assess potential impacts of the proposed project on an area-wide basis. It was inadequate to support analysis of potential impacts on specific locations selected for site characterization studies, mining an exploratory shaft, or the siting and operation of a repository

  4. Combining specificity determining and conserved residues improves functional site prediction

    Directory of Open Access Journals (Sweden)

    Gelfand Mikhail S

    2009-06-01

    Full Text Available Abstract Background Predicting the location of functionally important sites from protein sequence and/or structure is a long-standing problem in computational biology. Most current approaches make use of sequence conservation, assuming that amino acid residues conserved within a protein family are most likely to be functionally important. Most often these approaches do not consider many residues that act to define specific sub-functions within a family, or they make no distinction between residues important for function and those more relevant for maintaining structure (e.g. in the hydrophobic core. Many protein families bind and/or act on a variety of ligands, meaning that conserved residues often only bind a common ligand sub-structure or perform general catalytic activities. Results Here we present a novel method for functional site prediction based on identification of conserved positions, as well as those responsible for determining ligand specificity. We define Specificity-Determining Positions (SDPs, as those occupied by conserved residues within sub-groups of proteins in a family having a common specificity, but differ between groups, and are thus likely to account for specific recognition events. We benchmark the approach on enzyme families of known 3D structure with bound substrates, and find that in nearly all families residues predicted by SDPsite are in contact with the bound substrate, and that the addition of SDPs significantly improves functional site prediction accuracy. We apply SDPsite to various families of proteins containing known three-dimensional structures, but lacking clear functional annotations, and discusse several illustrative examples. Conclusion The results suggest a better means to predict functional details for the thousands of protein structures determined prior to a clear understanding of molecular function.

  5. The alternative site selection procedure as covered in the report by the Repository Site Selection Procedures Working Group

    International Nuclear Information System (INIS)

    Brenner, M.

    2005-01-01

    The 2002 Act on the Regulated Termination of the Use of Nuclear Power for Industrial Electricity Generation declared Germany's opting out of the peaceful uses of nuclear power. The problem of the permanent management of radioactive residues is becoming more and more important also in the light of that political decision. At the present time, there are no repositories offering the waste management capacities required. Such facilities need to be created. At the present stage, eligible repository sites are the Konrad mine, a former iron ore mine near Salzgitter, and the Gorleben salt dome. While the fate of the Konrad mine as a repository for waste generating negligible amounts of heat continues to be uncertain, despite a plan approval decision of June 2002, the Gorleben repository is still in the planning phase, at present in a dormant state, so to speak. The federal government expressed doubt about the suitability of the Gorleben site. Against this backdrop, the Federal Ministry for the Environment, Nature Conservation, and Nuclear Safety in February 1999 established AkEnd, the Working Group on Repository Site Selection Procedures. The Group was charged with developing, based on sound scientific criteria, a transparent site selection procedure in order to facilitate the search for repository sites. The Working Group presented its final report in December 2002 after approximately four years of work. The Group's proposals about alternative site selection procedures are explained in detail and, above all, reviewed critically. (orig.)

  6. Site descriptive modeling as a part of site characterization in Sweden - Concluding the surface based investigations

    International Nuclear Information System (INIS)

    Andersson, Johan; Winberg, Anders; Skagius, Kristina; Stroem, Anders; Lindborg, Tobias

    2007-01-01

    The Swedish Nuclear Fuel and Waste Management Co., SKB, is currently finalizing its surface based site investigations for the final repository for spent nuclear fuel in the municipalities of Oestharmnar (the Forsmark area) and Oskarshamn (the Simpevar/Laxemar area). The investigation data are assessed into a Site Descriptive Model, constituting a synthesis of geology, rock mechanics, thermal properties, hydrogeology, hydro-geochemistry, transport properties and a surface system description. Site data constitute a wide range of different measurement results. These data both need to be checked for consistency and to be interpreted into a format more amenable for three-dimensional modeling. The three-dimensional modeling (i.e. estimating the distribution of parameter values in space) is made in a sequence where the geometrical framework is taken from the geological models and in turn used by the rock mechanics, thermal and hydrogeological modeling. These disciplines in turn are partly interrelated, and also provide feedback to the geological modeling, especially if the geological description appears unreasonable when assessed together with the other data. Procedures for assessing the uncertainties and the confidence in the modeling have been developed during the course of the site modeling. These assessments also provide key input to the completion of the site investigation program. (authors)

  7. The use of desk studies, remote sensing and surface geological and geophysical techniques in site investigations

    International Nuclear Information System (INIS)

    Mather, J.D.

    1984-02-01

    The geoscientific investigations required to characterise a site for the underground disposal of radioactive wastes involve a wide range of techniques and expertise. Individual national investigations need to be planned with the specific geological environment and waste form in mind. However, in any investigation there should be a planned sequence of operations leading through desk studies and surface investigations to the more expensive and sophisticated sub-surface investigations involving borehole drilling and the construction of in situ test facilities. Desk studies are an important and largely underestimated component of site investigations. Most developed countries have archives of topographical, geological and environmental data within government agencies, universities, research institutes and learned societies. Industry is another valuable source but here confidentiality can be a problem. However, in developing countries and in some regions of developed countries the amount of basic data, which needs to be collected over many decades, will not be as extensive. In such regions remote sensing offers a rapid method of examining large areas regardless of land access, vegetation or geological setting, rapidly and at relatively low cost. It can also be used to examine features, such as discontinuity patterns, over relatively small areas in support of intensive ground investigations. Examples will be given of how remote sensing has materially contributed to site characterisation in a number of countries, particularly those such as Sweden, Canada and the United Kingdom where the major effort has concentrated on crystalline rocks. The main role of desk studies and surface investigations is to provide basic data for the planning and execution of more detailed subsurface investigations. However, such studies act as a valuable screening mechanism and if they are carried out correctly can enable adverse characteristics of a site to be identified at an early stage before

  8. Thermal site descriptive model. A strategy for the model development during site investigations - version 2

    International Nuclear Information System (INIS)

    Back, Paer-Erik; Sundberg, Jan

    2007-09-01

    This report presents a strategy for describing, predicting and visualising the thermal aspects of the site descriptive model. The strategy is an updated version of an earlier strategy applied in all SDM versions during the initial site investigation phase at the Forsmark and Oskarshamn areas. The previous methodology for thermal modelling did not take the spatial correlation fully into account during simulation. The result was that the variability of thermal conductivity in the rock mass was not sufficiently well described. Experience from earlier thermal SDMs indicated that development of the methodology was required in order describe the spatial distribution of thermal conductivity in the rock mass in a sufficiently reliable way, taking both variability within rock types and between rock types into account. A good description of the thermal conductivity distribution is especially important for the lower tail. This tail is important for the design of a repository because it affects the canister spacing. The presented approach is developed to be used for final SDM regarding thermal properties, primarily thermal conductivity. Specific objectives for the strategy of thermal stochastic modelling are: Description: statistical description of the thermal conductivity of a rock domain. Prediction: prediction of thermal conductivity in a specific rock volume. Visualisation: visualisation of the spatial distribution of thermal conductivity. The thermal site descriptive model should include the temperature distribution and thermal properties of the rock mass. The temperature is the result of the thermal processes in the repository area. Determination of thermal transport properties can be made using different methods, such as laboratory investigations, field measurements, modelling from mineralogical composition and distribution, modelling from density logging and modelling from temperature logging. The different types of data represent different scales, which has to be

  9. Thermal site descriptive model. A strategy for the model development during site investigations - version 2

    Energy Technology Data Exchange (ETDEWEB)

    Back, Paer-Erik; Sundberg, Jan [Geo Innova AB (Sweden)

    2007-09-15

    This report presents a strategy for describing, predicting and visualising the thermal aspects of the site descriptive model. The strategy is an updated version of an earlier strategy applied in all SDM versions during the initial site investigation phase at the Forsmark and Oskarshamn areas. The previous methodology for thermal modelling did not take the spatial correlation fully into account during simulation. The result was that the variability of thermal conductivity in the rock mass was not sufficiently well described. Experience from earlier thermal SDMs indicated that development of the methodology was required in order describe the spatial distribution of thermal conductivity in the rock mass in a sufficiently reliable way, taking both variability within rock types and between rock types into account. A good description of the thermal conductivity distribution is especially important for the lower tail. This tail is important for the design of a repository because it affects the canister spacing. The presented approach is developed to be used for final SDM regarding thermal properties, primarily thermal conductivity. Specific objectives for the strategy of thermal stochastic modelling are: Description: statistical description of the thermal conductivity of a rock domain. Prediction: prediction of thermal conductivity in a specific rock volume. Visualisation: visualisation of the spatial distribution of thermal conductivity. The thermal site descriptive model should include the temperature distribution and thermal properties of the rock mass. The temperature is the result of the thermal processes in the repository area. Determination of thermal transport properties can be made using different methods, such as laboratory investigations, field measurements, modelling from mineralogical composition and distribution, modelling from density logging and modelling from temperature logging. The different types of data represent different scales, which has to be

  10. Risk-based technical specifications program: Site interview results

    International Nuclear Information System (INIS)

    Andre, G.R.; Baker, A.J.; Johnson, R.L.

    1991-08-01

    The Electric Power Research Institute and Pacific Gas and Electric Company are sponsoring a program directed at improving Technical Specifications using risk-based methods. The major objectives of the program are to develop risk-based approaches to improve Technical Specifications and to develop an Interactive Risk Advisor (IRA) prototype. The IRA is envisioned as an interactive system that is available to plant personnel to assist in controlling plant operation. Use of an IRA is viewed as a method to improve plant availability while maintaining or improving plant safety. In support of the program, interviews were conducted at several PWR and BWR plant sites, to elicit opinions and information concerning risk-based approaches to Technical Specifications and IRA requirements. This report presents the results of these interviews, including the functional requirements of an IRA. 2 refs., 6 figs., 2 tabs

  11. Site-specific PEGylation of human thyroid stimulating hormone to prolong duration of action.

    Science.gov (United States)

    Qiu, Huawei; Boudanova, Ekaterina; Park, Anna; Bird, Julie J; Honey, Denise M; Zarazinski, Christine; Greene, Ben; Kingsbury, Jonathan S; Boucher, Susan; Pollock, Julie; McPherson, John M; Pan, Clark Q

    2013-03-20

    Recombinant human thyroid stimulating hormone (rhTSH or Thyrogen) has been approved for thyroid cancer diagnostics and treatment under a multidose regimen due to its short circulating half-life. To reduce dosing frequency, PEGylation strategies were explored to increase the duration of action of rhTSH. Lysine and N-terminal PEGylation resulted in heterogeneous product profiles with 40% or lower reaction yields of monoPEGylated products. Eleven cysteine mutants were designed based on a structure model of the TSH-TSH receptor (TSHR) complex to create unique conjugation sites on both α and β subunits for site-specific conjugation. Sequential screening of mutant expression level, oligomerization tendency, and conjugation efficiency resulted in the identification of the αG22C rhTSH mutant for stable expression and scale-up PEGylation. The introduced cysteine in the αG22C rhTSH mutant was partially blocked when isolated from conditioned media and could only be effectively PEGylated after mild reduction with cysteine. This produced a higher reaction yield, ~85%, for the monoPEGylated product. Although the mutation had no effect on receptor binding, PEGylation of αG22C rhTSH led to a PEG size-dependent decrease in receptor binding. Nevertheless, the 40 kDa PEG αG22C rhTSH showed a prolonged duration of action compared to rhTSH in a rat pharmacodynamics model. Reverse-phase HPLC and N-terminal sequencing experiments confirmed site-specific modification at the engineered Cys 22 position on the α-subunit. This work is another demonstration of successful PEGylation of a cysteine-knot protein by an engineered cysteine mutation.

  12. Specificity of cellular DNA-binding sites of microbial populations in a Florida reservoir

    International Nuclear Information System (INIS)

    Paul, J.H.; Pichard, S.L.

    1989-01-01

    The substrate specificity of the DNA-binding mechanism(s) of bacteria in a Florida reservoir was investigated in short- and long-term uptake studies with radiolabeled DNA and unlabeled competitors. Thymine oligonucleotides ranging in size from 2 base pairs to 19 to 24 base pairs inhibited DNA binding in 20-min incubations by 43 to 77%. Deoxynucleoside monophosphates, thymidine, and thymine had little effect on short-term DNA binding, although several of these compounds inhibited the uptake of the radiolabel from DNA in 4-h incubations. Inorganic phosphate and glucose-1-phosphate inhibited neither short- nor long-term binding of [ 3 H]- or [ 32 P]DNA, indicating that DNA was not utilized as a phosphorous source in this reservoir. RNA inhibited both short- and long-term radiolabeled DNA uptake as effectively as unlabeled DNA. Collectively these results indicate that aquatic bacteria possess a generalized nuclei acid uptake/binding mechanism specific for compounds containing phosphodiester bonds and capable of recognizing oligonucleotides as short as dinucleotides. This binding site is distinct from nucleoside-, nucleotide-, phosphomonoester-, and inorganic phosphate-binding sites. Such a nucleic acid-binding mechanism may have evolved for the utilization of extracellular DNA (and perhaps RNA), which is abundant in many marine and freshwater environments

  13. Construction over abandoned mine workings

    Energy Technology Data Exchange (ETDEWEB)

    Healy, P R; Head, J M

    1984-01-01

    Guidance is given for engineers involved with the planning and development of sites previously undermined for coal and other minerals. Past methods of mining employed in Britain are described, and their short- and long-term effects on surface stability are assessed. Where modern methods of mining are relevant, or where structural design techniques for the surface effects of mining can be applied, these are included for illustration and completeness. Additional objectives over and above those for conventional site investigations are identified, and details are provided for the planning and execution of a mining investigation. Techniques for consolidation of old mine workings and remedial measures for mine shafts are described. Foundation design options are included for cases where expected ground movements can be accommodated. A comprehensive guide to sources of information on previous mining is presented, together with an example of a specification suitable for the consolidation of old shallow mine workings. (50 refs.)

  14. Handball Practice Enhances Bone Mass in Specific Sites Among Prepubescent Boys.

    Science.gov (United States)

    Missawi, Kawther; Zouch, Mohamed; Chakroun, Yosra; Chaari, Hamada; Tabka, Zouhair; Bouajina, Elyès

    2016-01-01

    This investigation's purpose is to focus on the effects of practicing handball for at least 2 yr on bone acquisition among prepubescent boys. One hundred prepubescent boys aged 10.68 ± 0.85 yr were divided into 2 groups: 50 handball players (HP group) and 50 controls (C group). Bone mineral density (BMD), bone mineral content (BMC), and bone area (BA) were evaluated by using dual-photon X-ray absorptiometry on the whole body, lumbar spine (L2-L4), legs, arms, femoral necks, hips and radiuses. Results showed greater values of BMD in both right and left femoral neck and total hip in handball players than in controls. In addition, handball players had higher values of legs and right total hip BMC than controls without any obvious variation of BA measurement in all sites between groups. All results of the paired t-test displayed an obviously marked variation of bone mass parameters between the left and right sides in the trained group without any marked variation among controls. Data showed an increased BMD of the supporting sites between the left and the right leg among handball players. However, "BMC" results exhibited higher values in the right than in the left total hip, and in the right total radius than in the left correspondent site. In addition, differences in the "BA" measurements were observed in the left total hip and in the right arm. Specific bone sites are markedly stimulated by handball training in prepubescent boys. Copyright © 2016 International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved.

  15. Artificial coastal lagoons at solar salt-working sites: A network of habitats for specialised, protected and alien biodiversity

    Science.gov (United States)

    Herbert, Roger J. H.; Broderick, Lee G.; Ross, Kathryn; Moody, Chris; Cruz, Tamira; Clarke, Leo; Stillman, Richard A.

    2018-04-01

    There are concerns that novel structures might displace protected species, facilitate the spread of non-indigenous species, or modify native habitats. It is also predicted that ocean warming and the associated effects of climate change will significantly increase biodiversity loss within coastal regions. Resilience is to a large extent influenced by the magnitude of dispersal and level of connectivity within and between populations. Therefore it is important to investigate the distribution and ecological significance of novel and artificial habitats, the presence of protected and alien species and potential vectors of propagule dispersal. The legacy of solar salt-making in tropical and warm temperate regions is regionally extensive areas of artificial hypersaline ponds, canals and ditches. Yet the broad-scale contribution of salt-working to a network of benthic biodiversity has not been fully established. Artisanal, abandoned and historic salt-working sites were investigated along the Atlantic coast of Europe between southern England (50°N) and Andalucía, Spain (36°N). Natural lagoons are scarce along this macrotidal coast and are vulnerable to environmental change; however it is suspected that avian propagule dispersal is important in maintaining population connectivity. During bird migration periods, benthic cores were collected for infauna from 70 waterbodies across 21 salt-working sites in 5 coastal regions. Bird ringing data were used to investigate potential avian connectivity between locations. Lagoonal specialist species, some of international conservation importance, were recorded across all regions in the storage reservoirs and evaporation ponds of continental salinas, yet few non-indigenous species were observed. Potential avian propagule transport and connectivity within and between extant salt-working sites is high and these artificial habitats are likely to contribute significantly to a network of coastal lagoon biodiversity in Europe.

  16. Bioavailability of particulate metal to zebra mussels: biodynamic modelling shows that assimilation efficiencies are site-specific.

    Science.gov (United States)

    Bourgeault, Adeline; Gourlay-Francé, Catherine; Priadi, Cindy; Ayrault, Sophie; Tusseau-Vuillemin, Marie-Hélène

    2011-12-01

    This study investigates the ability of the biodynamic model to predict the trophic bioaccumulation of cadmium (Cd), chromium (Cr), copper (Cu), nickel (Ni) and zinc (Zn) in a freshwater bivalve. Zebra mussels were transplanted to three sites along the Seine River (France) and collected monthly for 11 months. Measurements of the metal body burdens in mussels were compared with the predictions from the biodynamic model. The exchangeable fraction of metal particles did not account for the bioavailability of particulate metals, since it did not capture the differences between sites. The assimilation efficiency (AE) parameter is necessary to take into account biotic factors influencing particulate metal bioavailability. The biodynamic model, applied with AEs from the literature, overestimated the measured concentrations in zebra mussels, the extent of overestimation being site-specific. Therefore, an original methodology was proposed for in situ AE measurements for each site and metal. Copyright © 2011 Elsevier Ltd. All rights reserved.

  17. The Nirex Sellafield site investigation: the role of geophysical interpretation

    International Nuclear Information System (INIS)

    Muir Wood, R.; Woo, G.; MacMillan, G.

    1992-01-01

    This report reviews the methods by which geophysical data are interpreted, and used to characterize the 3-D geology of a site for potential storage of radioactive waste. The report focuses on the NIREX site investigation at Sellafield, for which geophysical observations provide a significant component of the structural geological understanding. In outlining the basic technical principles of seismic data processing and interpretation, and borehole logging, an attempt has been made to identify errors, uncertainties, and the implicit use of expert judgement. To enhance the reliability of a radiological probabilistic risk assessment, recommendations are proposed for independent use of the primary NIREX geophysical site investigation data in characterizing the site geology. These recommendations include quantitative procedures for undertaking an uncertainty audit using a combination of statistical analysis and expert judgement. (author)

  18. Work-specific cognitive symptoms and the role of work characteristics, fatigue and depressive symptoms in cancer patients during 18 months post return to work.

    Science.gov (United States)

    Dorland, H F; Abma, F I; Roelen, C A M; Stewart, R; Amick, B C; Bültmann, U; Ranchor, A V

    2018-06-19

    Cancer patients can experience work-specific cognitive symptoms post return to work (RTW). The study aims to: 1) describe the course of work-specific cognitive symptoms in the first 18 months post RTW, and 2) examine the associations of work characteristics, fatigue and depressive symptoms with work-specific cognitive symptoms over time. This study used data from the 18-months longitudinal "Work Life after Cancer" cohort. The Cognitive Symptom Checklist-Work, Dutch Version (CSC-W DV) was used to measure work-specific cognitive symptoms. Linear mixed models were performed to examine the course of work-specific cognitive symptoms during 18 months follow-up; linear regression analyses with generalised estimating equations (GEE) were used to examine associations over time. Working cancer patients diagnosed with different cancer types were included (n=378). Work-specific cognitive symptoms were stable over 18 months. At baseline, cancer patients reported more working memory symptoms (M=31.9, CI=23.1, 26.4) compared to executive function symptoms (M=19.3; CI=17.6, 20.9). Cancer patients holding a job with both manual and non-manual tasks reported less work-specific cognitive symptoms (unstandardized regression coefficient b=-4.80; CI=-7.76, -1.83) over time, compared to cancer patients with a non-manual job. Over time, higher depressive symptoms were related to experiencing more overall work-specific cognitive symptoms (b=1.27; CI=1.00, 1.55) and a higher fatigue score was related to more working memory symptoms (b=0.13; CI=0.04, 0.23). Job type should be considered when looking at work-specific cognitive symptoms over time in working cancer patients. To reduce work-specific cognitive symptoms, interventions targeted at fatigue and depressive symptoms might be promising. This article is protected by copyright. All rights reserved.

  19. DAFS study of site-specific local structure of Mn in manganese ferrite films

    International Nuclear Information System (INIS)

    Kravtsov, E.; Haskel, D.; Cady, A.; Yang, A.; Vittoria, C.; Zuo, X.; Harris, V.G.

    2006-01-01

    Manganese ferrite (MnFe 2 O 4 ) is a well-known magnetic material widely used in electronics for many years. It is well established that its magnetic behavior is strongly influenced by local structural properties of Mn ions, which are distributed between crystallographically inequivalent tetrahedral and octahedral sites in the unit cell. In order to understand and be able to tune properties of these structures, it is necessary to have detailed site-specific structural information on the system. Here we report on the application of diffraction-anomalous fine structure (DAFS) spectroscopy to resolve site-specific Mn local structures in manganese ferrite films. The DAFS measurements were done at undulator beamline 4-ID-D of the Advanced Photon Source at Argonne National Laboratory. The DAFS spectra (Fig. 1) were measured at several Bragg reflections in the vicinity of the Mn absorption K-edge, having probed separately contributions from tetrahedrally and octahedrally coordinated Mn sites. The DAFS data analysis done with an iterative Kramers-Kroenig algorithm made it possible to solve separately the local structure around different inequivalent Mn sites in the unit cell. The reliability of the data treatment was checked carefully, and it was showed that the site-specific structural parameters obtained with DAFS allow us to describe fluorescence EXAFS spectrum measured independently. Fig. 2 shows individual site contributions to the imaginary part of the resonant scattering amplitude obtained from the treatment of the data of Fig. 1. The analysis of the refined site-specific absorption spectra was done using EXAFS methods based on theoretical standards. We provided direct evidence for the tetrahedral Mn-O bond distance being increased relative to the corresponding Fe-O distance in bulk manganese ferrites. The first coordination shell number was found to be reduced significantly for Mn atoms at these sites. This finding is consistent with the well-known tendency of Mn

  20. Geotechnical investigation for seismic issues for K-reactor area at Savannah River Site

    International Nuclear Information System (INIS)

    Castro, G.; Reeves, C.Q.

    1991-01-01

    A geotechnical investigation has been completed at Savannah River Site to characterize the foundation conditions in K-Reactor Area and confirm soil design properties for use in seismic qualification of structures. The scope of field work included ten soil borings to a 200-foot depth with split-spoon and undisturbed sampling. Additionally, 42 cone penetrometer tests were performed with seismic down-hole measurements. Three cross-hole shear wave velocity tests were also completed to confirm the assumed dynamic properties which had been used in preliminary seismic analysis