WorldWideScience

Sample records for invasion locus sil

  1. A minimally invasive surgery robotic assistant for HALS-SILS techniques.

    Science.gov (United States)

    Bauzano, E; Garcia-Morales, I; del Saz-Orozco, P; Fraile, J C; Muñoz, V F

    2013-11-01

    This paper is focused in the design and implementation of a robotic surgical motion controller. The proposed control scheme addresses the issues related to the application of a robot assistant in novel surgical scenario, which combines hand assisted laparoscopic surgery (HALS) with the single incision laparoscopic surgery (SILS) techniques. It is designed for collaborating with the surgeon in a natural way, by performing autonomous movements, in order to assist the surgeon during a surgical maneuver. In this way, it is implemented a hierarchical architecture which includes an upper auto-guide velocity planner connected to a low-level force feedback controller. The first one, based on a behavior approach, computes a collision free trajectory of the surgical instrument tip, held by the robot, for reaching a goal location inside of the abdominal cavity. On the other hand, the force feedback controller uses this trajectory for performing the instrument displacement by taking into account the holonomic movement constraints introduced by the fulcrum point. The aim of this controller is positioning the surgical instrument by minimizing the forces exerted over the abdominal wall due to the fulcrum location uncertainty. The overall system has been integrated in the control architecture of the surgical assistant CISOBOT, designed and developed at the University of Malaga. The whole architecture performance has been tested by means of in vitro trials. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  2. Regulation of sagA, siaA and scpC by SilCR, a putative signaling peptide of Streptococcus pyogenes.

    Science.gov (United States)

    Salim, Kowthar Y; de Azavedo, Joyce C; Bast, Darrin J; Cvitkovitch, Dennis G

    2008-12-01

    SilCR, a 17 amino acid putative signaling peptide, was proposed to modulate gene expression in Streptococcus pyogenes. We showed that SilCR added exogenously to an M1 serotype strain lacking the sil locus upregulates the in vitro expression of sagA, siaA, and scpC, genes associated with S. pyogenes pathogenesis. Interestingly, only sagA and siaA were upregulated by SilCR in vivo, whereas the expression of scpC remained unaltered. A previous report indicated that exogenously added SilCR protects mice to some degree from developing necrotic lesions caused by an invasive strain of S. pyogenes. In contrast to this report, we found that SilCR did not reduce lesion formation in a subcutaneous murine model of S. pyogenes infection but rather appeared to delay wound healing.

  3. Analysis of non-typeable Haemophilus influenzae in invasive disease reveals lack of the capsule locus.

    Science.gov (United States)

    Lâm, T-T; Claus, H; Frosch, M; Vogel, U

    2016-01-01

    Among invasive Haemophilus influenzae, unencapsulated strains have largely surpassed the previously predominant serotype b (Hib) because of Hib vaccination. Isolates without the genomic capsule (cap) locus are designated non-typeable H. influenzae (NTHi). They are different from capsule-deficient variants that show deletion of the capsule transport gene bexA within the cap locus. The frequency of capsule-deficient variants in invasive disease is unknown. We analysed 783 unencapsulated invasive isolates collected over 5 years in Germany and found no single capsule-deficient isolate. Invasive unencapsulated strains in Germany were exclusively NTHi. A negative serotyping result by slide agglutination was therefore highly predictive for NTHi. Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

  4. Research System Integration Laboratory (SIL)

    Data.gov (United States)

    Federal Laboratory Consortium — The VEA Research SIL (VRS) is essential to the success of the TARDEC 30-Year Strategy. The vast majority of the TARDEC Capability Sets face challenging electronics...

  5. Transformed Recombinant Enrichment Profiling Rapidly Identifies HMW1 as an Intracellular Invasion Locus in Haemophilus influenzae

    Science.gov (United States)

    Moleres, Javier; Sinha, Sunita; Fernández-Calvet, Ariadna; Porsch, Eric A.; St. Geme, Joseph W.; Nislow, Corey; Redfield, Rosemary J.; Garmendia, Junkal

    2016-01-01

    Many bacterial species actively take up and recombine homologous DNA into their genomes, called natural competence, a trait that offers a means to identify the genetic basis of naturally occurring phenotypic variation. Here, we describe “transformed recombinant enrichment profiling” (TREP), in which natural transformation is used to generate complex pools of recombinants, phenotypic selection is used to enrich for specific recombinants, and deep sequencing is used to survey for the genetic variation responsible. We applied TREP to investigate the genetic architecture of intracellular invasion by the human pathogen Haemophilus influenzae, a trait implicated in persistence during chronic infection. TREP identified the HMW1 adhesin as a crucial factor. Natural transformation of the hmw1 operon from a clinical isolate (86-028NP) into a laboratory isolate that lacks it (Rd KW20) resulted in ~1,000-fold increased invasion into airway epithelial cells. When a distinct recipient (Hi375, already possessing hmw1 and its paralog hmw2) was transformed by the same donor, allelic replacement of hmw2A Hi375 by hmw1A 86-028NP resulted in a ~100-fold increased intracellular invasion rate. The specific role of hmw1A 86-028NP was confirmed by mutant and western blot analyses. Bacterial self-aggregation and adherence to airway cells were also increased in recombinants, suggesting that the high invasiveness induced by hmw1A 86-028NP might be a consequence of these phenotypes. However, immunofluorescence results found that intracellular hmw1A 86-028NP bacteria likely invaded as groups, instead of as individual bacterial cells, indicating an emergent invasion-specific consequence of hmw1A-mediated self-aggregation. PMID:27124727

  6. Genetic architecture of contemporary adaptation to biotic invasions: quantitative trait locus mapping of beak reduction in soapberry bugs.

    Science.gov (United States)

    Yu, Y; Andrés, Jose A

    2014-02-19

    Biological invasions can result in new selection pressures driven by the establishment of new biotic interactions. The response of exotic and native species to selection depends critically on the genetic architecture of ecologically relevant traits. In the Florida peninsula, the soapberry bug (Jadera haematoloma) has colonized the recently introduced Chinese flametree, Koelreuteria elegans, as a host plant. Driven by feeding efficiency, the populations associated with this new host have differentiated into a new bug ecomorph characterized by short beaks more appropriate for feeding on the flattened pods of the Chinese flametree. In this study, we have generated a three-generation pedigree from crossing the long-beaked and short-beaked ecomorphs to construct a de novo linkage map and to locate putative quantitative trait locus (QTL) controlling beak length and body size in J. haematoloma. Using amplified fragment-length polymorphism markers and a two-way pseudo-testcross design, we have produced two parental maps in six linkage groups, covering the known number of chromosomes. QTL analysis revealed one significant QTL for beak length on a maternal linkage group and the corresponding paternal linkage group. Three QTL were found for body size. Through single marker regression analysis, nine single markers that could not be placed on the map were also found to be significantly associated with one or both of the two traits. Interestingly, the most significant body size QTL co-localized with the beak length QTL, suggesting linkage disequilibrium or pleiotropic effects of related traits. Our results suggest an oligogenic control of beak length.

  7. Single incision laparoscopic surgery (SILS) in gynaecology: feasibility and operative outcomes.

    Science.gov (United States)

    Behnia-Willison, Fariba; Foroughinia, Leila; Sina, Maryam; McChesney, Phil

    2012-08-01

    Single incision laparoscopic surgery (SILS) represents the latest advancement in minimally invasive surgery, combining the benefits of conventional laparoscopic surgery, such as less pain and faster recovery, with improved cosmesis. Although the successful use of this technique is well reported in general surgery and urology, there is a lack of studies on SILS in gynaecology. To evaluate the feasibility, safety, cosmesis and outcome of SILS in gynaecology. A prospective case series analysis of 105 women scheduled to undergo surgery by SILS from August 2010 to November 2011. Intra-operative data such as operative time, estimated blood loss, complications, additional ports and hospital stay were collected. Post-operative pain and cosmetic outcomes (scar size) were also recorded. Out of 105 women, SILS was performed for 84 (60 excisions of endometriosis, 13 divisions of adhesions, five hysterectomies, two mesh sacrohysteropexies and four ovarian cystectomies). SILS was not undertaken for 21 women because of a number of factors, including the lack of required equipment (eg bariatric scope, SILS port, roticulating instruments and diathermy leads). Four women required insertion of additional ports because of surgical difficulties. One intra-operative (uterine perforation) and seven post-operative complications (six wound infections and one vault haematoma) occurred. Mean operation times were as follows: mesh sacrohysteropexy - 60 min, excision of endometriosis - 55 min, hysterectomy - 150 min, laparoscopic division of adhesions - 62 min and ovarian cystectomy - 40 min. Our experience shows that SILS is a feasible and safe technique for the surgical management of various gynaecological conditions. Satisfaction is high because of improved cosmesis and reduced analgesic requirements post-operatively. © 2012 The Authors ANZJOG © 2012 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists.

  8. Differential contribution of tryptophans to the folding and stability of the attachment invasion locus transmembrane β-barrel from Yersinia pestis.

    Science.gov (United States)

    Gupta, Ankit; Zadafiya, Punit; Mahalakshmi, Radhakrishnan

    2014-09-30

    Attachment invasion locus (Ail) protein of Yersinia pestis is a crucial outer membrane protein for host invasion and determines bacterial survival within the host. Despite its importance in pathogenicity, surprisingly little is known on Ail biophysical properties. We investigate the contribution of micelle concentrations and interface tryptophans on the Ail β-barrel refolding and unfolding processes. Our results reveal that barrel folding is surprisingly independent of micelle amounts, but proceeds through an on-pathway intermediate that requires the interface W42 for cooperative barrel refolding. On the contrary, the unfolding event is strongly controlled by absolute micelle concentrations. We find that upon Trp → Phe substitution, protein stabilities follow the order W149F>WT>W42F for the refolding, and W42F>WT>W149F for unfolding. W42 confers cooperativity in barrel folding, and W149 clamps the post-folded barrel structure to its micelle environment. Our analyses reveal, for the first time, that interface tryptophan mutation can indeed render greater β-barrel stability. Furthermore, hysteresis in Ail stems from differential barrel-detergent interaction strengths in a micelle concentration-dependent manner, largely mediated by W149. The kinetically stabilized Ail β-barrel has strategically positioned tryptophans to balance efficient refolding and subsequent β-barrel stability, and may be evolutionarily chosen for optimal functioning of Ail during Yersinia pathogenesis.

  9. Cloning, expression and characterization of attachment-invasion locus protein (Ail) of Yersinia enterocolitica and its utilization in rapid detection by immunoassays.

    Science.gov (United States)

    Balakrishna, K; Murali, H S; Batra, H V

    2010-02-01

    Rapid detection of pathogenic Yersinia enterocolitica isolates by using antisera raised against recombinant attachment-invasion locus (Ail) protein. The complete gene (471 bp) encoding for the Ail protein was amplified by PCR and cloned in pQE 30 UA vector. The recombinant clones were selected by polymerase chain reaction (PCR). Recombinant protein was expressed using induction with 1 mmol l(-1) final concentration of isopropylthiogalactoside (IPTG). Polyclonal antibodies were raised in mice against this purified recombinant protein. An indirect plate ELISA was standardized based on rAil protein for the detection of Y. enterocolitica. Western blot analysis with the sera raised against recombinant Ail protein exhibited reaction at 17 kDa region of the native Ail protein present in pathogenic Y. enterocolitica standard strains and strains isolated from pork samples suggesting that the antigenicity of recombinant Ail protein was similar to that of native Ail protein. Nonpathogenic Y. enterocolitica and the other species of Yersinia, namely, Y. pseudotuberculosis, Y. intermedia, Y. kristenseni, Y. fredrickseni and also the Enterobacteriaceae organisms tested were not found reacting to polyclonal antisera against this recombinant Ail protein. The antibodies raised against recombinant Ail protein could specifically identify pathogenic Y. enterocolitica strains both by indirect plate ELISA and Western blot immunoassay. The method developed in this study may find application in the detection of pathogenic Y. enterocolitica not only from food and environmental samples but also from clinical samples.

  10. O silêncio do anjo

    Directory of Open Access Journals (Sweden)

    Ana Maria Portugal Saliba

    2013-08-01

    Full Text Available A partir dos enaios do escritor W.G.Sebald, que discorre sobre o silêncio dos escritores alemães no período pos-guerra, ampliamos a questão para o campo da psicanálise e articulamos com a expressão do filósofo Alain Badiou "paixão pelo real", diante de que este autor proõe uma "via subtrativa".

  11. Case-mix study of single incision laparoscopic surgery (SILS) vs. Conventional laparoscopic surgery in colonic cancer resections

    DEFF Research Database (Denmark)

    Mynster, Tommie; Wille-Jørgensen, Peer

    2013-01-01

    of administrations or amount of opioids were seen. Conclusion. With reservation of a small study group we find SILS is like worthy to CLS in colorectal cancer surgery and a benefit in postoperative recovery and pain is possible, but has to be investigated in larger randomised studies.......Single incision laparoscopic surgery (SILS) may be even less invasive to a patient than conventional laparoscopic surgery (CLS). Aim of the study of the applicability of the procedure, the first 1½ year of experiences and comparison with CLS for colonic cancer resections Material and methods. Since...

  12. Correlation between genotypic diversity, lipooligosaccharide gene locus class variation and Caco-2 invasion potential of Campylobacter jejuni from human and chicken meat origin: a contribution to virulotyping

    Science.gov (United States)

    Significant interest in studying the lipooligosaccharide (LOS) of Campylobacter jejuni stemmed from its potential role in post-infection paralytic disorders. In this study we present PCR screening of five LOS locus classes (A, B, C, D, and E), for a collection of 117 C. jejuni strains from chicken m...

  13. DIRECTIONS IN THE EVOLUTION OF CERVICAL L-SIL LESIONS

    Directory of Open Access Journals (Sweden)

    Momcilo Djordjevic

    2005-01-01

    Full Text Available Molecular activities in the basic cytopathological substratum of the lesions on utherus cervicus, in case of HPV infection in form of squamous intraepithelial lesions of the low (L - SIL and high (H - SIL level, are defined by bathesda therminological system. More frequent, L - SIL changes include CIN I, coil atypia and condilomata lata and can be recognized by cellular abnormalities in the basal and parabasal layer with minor cellular structural changes , nuclei hyperhromasia with hromatin condensation, acantosis, paraceratosis with well differentiated cells and faster exfoliation. Women more prone to develop L-SIL are those older than 41, with III degree of vaginal secretion, with the colposcopic finding of aceto-white epithelium and Papa-Nicholaus test of III group. The control cervical, colposcopically controlled biopsy was resumed after four control medical check-ups done every three months after the L-SIL diagnosis. The results showed that lesions remained at the same stage (41,67%, whereas regression appeared in every third examinee (33,33%, slight progression in every eight examinee (12,50%, and significant progression in every twelfth examinee (8,33%.Our conclusion was that L-SIL lesions do not require the ablativ therapy a priory, and what is needed is a regular colpocytological check-up every three months and cervical biopsy, if necessary. Diagnosis of HPV infection certainly changes one’s attitude and requires loop diameter because of the additional diagnostic indications and final therapy.

  14. Prevention of postoperative pericardial adhesions with TachoSil.

    Science.gov (United States)

    Kuschel, Tarah J; Gruszka, Anna; Hermanns-Sachweh, Benita; Elyakoubi, Jaouad; Sachweh, Joerg S; Vázquez-Jiménez, Jaime F; Schnoering, Heike

    2013-01-01

    The prevention of the pericardial adhesions largely accountable for the technical difficulty and risk of injury inherent to resternotomy continues to gain in importance with the increasing frequency of reoperations. The hemostatic sponge TachoSil (Nycomed Austria GmbH, Linz, Austria), has shown promising results in adhesion prevention in several regions of the body. This study was designed to evaluate its effectiveness in the prevention of pericardial adhesions in comparison with the Gore-Tex (W. L. Gore and Assoc, Flagstaff, AZ) surgical membrane and a control. Twenty-four rabbits were distributed into 3 groups: TachoSil, Gore-Tex, or no barrier agent (control). After median sternotomy and pericardiotomy, the cardial surface was exposed to the aggravating effects of room air, irrigation, and gauze abrasion for one hour. A pericardial defect was created and repaired with one of the barrier agents, or left uncovered (control). Resternotomy was performed after 6 months for the evaluation of adhesion formation. Significantly fewer macroscopic adhesions were observed with TachoSil than Gore-Tex in all regions (p Gore-Tex and the control. Microscopically, the least pronounced fibrosis formation and inflammatory reaction was detected with TachoSil. TachoSil is effective in the prevention of pericardial adhesions. Copyright © 2013 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  15. Single-incision laparoscopic surgery: outcomes from 224 colonic resections performed at a single center using SILS.

    Science.gov (United States)

    Vestweber, Boris; Galetin, Thomas; Lammerting, Kathrin; Paul, Claudia; Giehl, Jeanette; Straub, Eberhard; Kaldowski, Bodo; Alfes, Angelika; Vestweber, Karl-Heinz

    2013-02-01

    Compared with single-incision laparoscopy, multiport laparoscopy is associated with greater risk of postoperative wound pain, infection, incisional hernias, and suboptimal cosmetic outcomes. The feasibility of minimally invasive single-incision laparoscopic surgery (SILS) for colorectal procedures is well-established, but outcome data remain limited. Patients with benign diverticular disease, Crohn's disease, or ulcerative colitis admitted to Klinikum Leverkusen, Germany, for colonic resection between July 2009 and March 2011 (n = 224) underwent single-incision laparoscopic surgery using the SILS port system. Surgeons had ≥7 years' experience in laparoscopic colon surgery but no SILS experience. Patient demographic and clinical data were collected prospectively. Pain was evaluated by using a visual analog scale (0-10). Data were analyzed by using the SPSS PASW Statistics 18 database. The majority of patients underwent sigmoid colectomy with high anterior resection (AR) or left hemicolectomy (n = 150) for diverticulitis. Our conversion rate to open surgery was 6.3 %, half in patients undergoing sigmoid colectomy with high AR or left hemicolectomy, 95 % of whom had diverticulitis. Mean operating time was 166 ± 74 (range, 40-441) min in the overall population, with shorter times for single-port transanal tumor resection (SPTTR; 89 ± 51 min; range, 40-153 min) and longer times for proctocolectomy (325 min; range, 110-441 min). Mean hospital stay was approximately 10 days, longer after abdominoperineal rectal resection or proctocolectomy (12-16 days). Most complications occurred following sigmoid colectomy with high AR or left hemicolectomy [19/25 (76 %) of early and 4/5 (80 %) of late complications, respectively]. Pain was surgery, conducted by experienced laparoscopic surgeons without specific training in use of the SILS port.

  16. Áreas de silêncio e corpo diabético

    Directory of Open Access Journals (Sweden)

    Maria da Glória Santana

    Full Text Available O texto busca refletir a respeito da experiência vivida pelo ser humano e diabético, ao ter que enfrentar a perda de alguma parte do seu corpo. Fundamentou-se a reflexão em Merleau-Ponty (1971, partindo de sua afirmativa de que o corpo fala e portanto também silencia. Mas que silêncio é esse de que me refiro? Um silêncio simbólico, mais silencioso que o verdadeiro silêncio. Um silêncio forte, pesado e significativo. Um silêncio que atordoa, permanente e eterno. Um silêncio que marca, que lembra e que também se adapta. Um silêncio proveniente da vida e da adaptação a nova forma de viver.

  17. Inhibition of HIV by Legalon-SIL is independent of its effect on cellular metabolism

    Energy Technology Data Exchange (ETDEWEB)

    McClure, Janela [Department of Laboratory Medicine, University of Washington, Seattle, WA (United States); Margineantu, Daciana H. [Department of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA (United States); Sweet, Ian R. [Department of Medicine (Division of Metabolism, Endocrinology, and Nutrition), University of Washington, Seattle, WA (United States); Polyak, Stephen J., E-mail: polyak@uw.edu [Department of Laboratory Medicine, University of Washington, Seattle, WA (United States); Department of Global Health, University of Washington, Seattle, WA (United States)

    2014-01-20

    In this report, we further characterized the effects of silibinin (SbN), derived from milk thistle extract, and Legalon-SIL (SIL), a water-soluble derivative of SbN, on T cell metabolism and HIV infection. We assessed the effects of SbN and SIL on peripheral blood mononuclear cells (PBMC) and CEM-T4 cells in terms of cellular growth, ATP content, metabolism, and HIV infection. SIL and SbN caused a rapid and reversible (upon removal) decrease in cellular ATP levels, which was associated with suppression of mitochondrial respiration and glycolysis. SbN, but not SIL inhibited glucose uptake. Exposure of T cells to SIL (but not SbN or metabolic inhibitors) during virus adsorption blocked HIV infection. Thus, both SbN and SIL rapidly perturb T cell metabolism in vitro, which may account for its anti-inflammatory and anti-proliferative effects that arise with prolonged exposure of cells. However, the metabolic effects are not involved in SIL's unique ability to block HIV entry. - Highlights: • Silibinin (SbN) and Legalon-SIL (SIL) are cytoprotective mixtures of natural products. • SbN and SIL reduce T cell oxidative phosphorylation and glycolysis in vitro. • SIL but not SbN blocks entry of multiple HIV isolates into T cells in vitro. • SIL's suppression of HIV appears independent of its effects on T cell metabolism. • Metabolic effects of SIL and SbN may be relevant in inflammatory diseases.

  18. Inhibition of HIV by Legalon-SIL is independent of its effect on cellular metabolism

    International Nuclear Information System (INIS)

    McClure, Janela; Margineantu, Daciana H.; Sweet, Ian R.; Polyak, Stephen J.

    2014-01-01

    In this report, we further characterized the effects of silibinin (SbN), derived from milk thistle extract, and Legalon-SIL (SIL), a water-soluble derivative of SbN, on T cell metabolism and HIV infection. We assessed the effects of SbN and SIL on peripheral blood mononuclear cells (PBMC) and CEM-T4 cells in terms of cellular growth, ATP content, metabolism, and HIV infection. SIL and SbN caused a rapid and reversible (upon removal) decrease in cellular ATP levels, which was associated with suppression of mitochondrial respiration and glycolysis. SbN, but not SIL inhibited glucose uptake. Exposure of T cells to SIL (but not SbN or metabolic inhibitors) during virus adsorption blocked HIV infection. Thus, both SbN and SIL rapidly perturb T cell metabolism in vitro, which may account for its anti-inflammatory and anti-proliferative effects that arise with prolonged exposure of cells. However, the metabolic effects are not involved in SIL's unique ability to block HIV entry. - Highlights: • Silibinin (SbN) and Legalon-SIL (SIL) are cytoprotective mixtures of natural products. • SbN and SIL reduce T cell oxidative phosphorylation and glycolysis in vitro. • SIL but not SbN blocks entry of multiple HIV isolates into T cells in vitro. • SIL's suppression of HIV appears independent of its effects on T cell metabolism. • Metabolic effects of SIL and SbN may be relevant in inflammatory diseases

  19. Advancements Made to the Wingman Software-in-the-Loop (SIL) Simulation: How to Operate the SIL

    Science.gov (United States)

    2017-12-01

    critical to achieve Training and Doctrine Command 6+1-required capabilities for robotics and autonomous systems. This report describes the SIL... integration event: January 2017. Aberdeen Proving Ground (MD): Army Research Laboratory (US); 2017 June. Report No.: ARL-TN-0830. [TRADOC] US Army...public release; distribution is unlimited. NOTICES Disclaimers The findings in this report are not to be construed as an official Department of

  20. VPLIV VAN DER WAALSOVIH SIL NA TVORBO ASOCIIRANIH MOLEKUL

    OpenAIRE

    Kuster, Bernarda

    2014-01-01

    Namen diplomske naloge je preučiti vpliv van der Waalsovih sil na tvorbo asociiranih molekul. V ta namen smo izbrali površinsko aktivne snovi, ki imajo amfifilne lastnosti in vplivajo na povšinske in medfazne napetosti ter pri določeni koncentraciji, imenovani kritična micelna koncentracija (CMC), tvorijo molekulske skupke, ki jim pravimo micele. Kritično micelno koncentracijo smo določili trem površinsko aktivnim snovem: heksadeciltrimetilamonijevemu bromidu, tetradeciltrimetilamonijevemu b...

  1. High frequency of silver resistance genes in invasive isolates of Enterobacter and Klebsiella species.

    Science.gov (United States)

    Sütterlin, S; Dahlö, M; Tellgren-Roth, C; Schaal, W; Melhus, Å

    2017-07-01

    Silver-based products have been marketed as an alternative to antibiotics, and their consumption has increased. Bacteria may, however, develop resistance to silver. To study the presence of genes encoding silver resistance (silE, silP, silS) over time in three clinically important Enterobacteriaceae genera. Using polymerase chain reaction (PCR), 752 bloodstream isolates from the years 1990-2010 were investigated. Age, gender, and ward of patients were registered, and the susceptibility to antibiotics and silver nitrate was tested. Clonality and single nucleotide polymorphism were assessed with repetitive element sequence-based PCR, multi-locus sequence typing, and whole-genome sequencing. Genes encoding silver resistance were detected most frequently in Enterobacter spp. (48%), followed by Klebsiella spp. (41%) and Escherichia coli 4%. Phenotypical resistance to silver nitrate was found in Enterobacter (13%) and Klebsiella (3%) isolates. The lowest carriage rate of sil genes was observed in blood isolates from the neonatology ward (24%), and the highest in blood isolates from the oncology/haematology wards (66%). Presence of sil genes was observed in international high-risk clones. Sequences of the sil and pco clusters indicated that a single mutational event in the silS gene could have caused the phenotypic resistance. Despite a restricted consumption of silver-based products in Swedish health care, silver resistance genes are widely represented in clinical isolates of Enterobacter and Klebsiella species. To avoid further selection and spread of silver-resistant bacteria with a high potential for healthcare-associated infections, the use of silver-based products needs to be controlled and the silver resistance monitored. Copyright © 2017 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

  2. Single-incision Laparoscopic Surgery (SILS) in general surgery: a review of current practice.

    Science.gov (United States)

    Froghi, Farid; Sodergren, Mikael Hans; Darzi, Ara; Paraskeva, Paraskevas

    2010-08-01

    Single-incision laparoscopic surgery (SILS) aims to eliminate multiple port incisions. Although general operative principles of SILS are similar to conventional laparoscopic surgery, operative techniques are not standardized. This review aims to evaluate the current use of SILS published in the literature by examining the types of operations performed, techniques employed, and relevant complications and morbidity. This review considered a total of 94 studies reporting 1889 patients evaluating 17 different general surgical operations. There were 8 different access techniques reported using conventional laparoscopic instruments and specifically designed SILS ports. There is extensive heterogeneity associated with operating methods and in particular ways of overcoming problems with retraction and instrumentation. Published complications, morbidity, and hospital length of stay are comparable to conventional laparoscopy. Although SILS provides excellent cosmetic results and morbidity seems similar to conventional laparoscopy, larger randomized controlled trials are needed to assess the safety and efficacy of this novel technique.

  3. Cre-/IoxP-Mediated Recombination between the SIL and SCL Genes Leads to a Block in T-Cell Development at the CD4-CD8- to CD4+CD8+ Transition

    Directory of Open Access Journals (Sweden)

    Yue Cheng

    2007-04-01

    Full Text Available In the most common form of stem cell leukemia (SCL gene rearrangement, an interstitial deletion of 82 kb brings SCL under the control of regulatory elements that normally govern expression of the ubiquitously expressed SCL interrupting locus (SIL gene, which is located directly upstream of SCL. To investigate the effect of this fusion in a mouse model, a bacterial artificial chromosome (BAC clone containing both human SIL and SCL genes was isolated, and IoxP sites were inserted into intron 1 of both the SIL and SCL genes, corresponding to the sites at which recombination occurs in human T-cell acute lymphocytic leukemia patients. This BAC clone was used to generate transgenic SILIoxloxSCL mice. These transgenic mice were subsequently bred to Lck-Cre mice that express the Cre recombinase specifically in the thymus. The BAC transgene was recombined between the two IoxP sites in over 50% of the thymocytes from SILIoxloxSCL/Cre double-transgenic mice, bringing the SCL gene under the direct control of SIL regulatory elements. Aberrant SCL gene expression in the thymus was verified by reverse transcription- polymerase chain reaction. Using FACS analysis, we found that mice carrying both SILIoxloxSCL and Cre transgenes have increased CD4-/CD8- thymocytes compared with transgenenegative mice. In the spleen, these transgenic mice show a marked reduction in the number of mature CD4+ or CD8+ cells. These results demonstrate that conditional activation of SCL under control of SIL regulatory elements can impair normal T-cell development.

  4. The reconstructive role of TachoSil in neurosurgery

    Directory of Open Access Journals (Sweden)

    Graziano Francesca, MD

    2016-12-01

    Full Text Available Hemorrhages, cerebrospinal fluid (CSF fistula and infections are the most challenging post-operative complications in Neurosurgery [1–5]. Fibrin sealant agents have been developed with the aim to provide efficient hemostasis and safe dural closure [3,6–14]. In this study we report our initial experience using TachoSil® (haemostatic surgical patch; Nycomed, Linz, Austria in achieving hemostasis and CSF leakage repair during cranio-cerebral procedures [15–18]. We describe and show the unique features of this fibrin sealant, pioneered with stunning success in many surgical procedures known to be at high risk of peri- and postoperative bleeding (i.e. nephrectomies, pulmonary lobectomies, ballistic injuries, arthroplasties, coronary bypass graftings, but still not widely exploited at its best in the field of Neurosurgery.

  5. On forge des partenariats au Brésil | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    9 mai 2011 ... La collaboration entre les différents établissements brésiliens reconnus dans leur champ d'expertise donne du poids aux arguments quand il s'agit de s'adresser aux décideurs, conclut Mme Padua. Instituto de Pesquisas Ecologicas, Brésil Fundação Oswaldo Cruz (FIOCRUZ), Brésil Faculté de médecine ...

  6. On the Role of sIL-2R Measurements in Rheumatoid Arthritis and Cancers

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    Anna Maria Witkowska

    2005-01-01

    diseases of different pathology. Moreover, the soluble receptor has been considered, at least in part, responsible for unsuccessful immunotherapy with IL-2 in cancers. Several lines of evidence indicate sIL-2R measurements to be useful in determining disease progress and prognosis. This review summarizes current knowledge on the sIL-2R behavior in RA and solid cancers of varied etiology.

  7. SILS: Is It Cost- and Time-Effective Compared to Standard Pediatric Laparoscopic Surgery?

    Science.gov (United States)

    Islam, Saidul; Adams, Stephen D; Mahomed, Anies A

    2012-01-01

    The aim of the study was to review our experience with single-incision laparoscopic surgery (SILS) and to compare costs and operative time to standard laparoscopic surgery (SLS). A prospectively collected database of operative times and costs was analysed for the years 2008-2011. SILS cases were compared to standard laparoscopy on a procedure-matched basis. Patient demographics, on-table time and consumable costs were collated. Descriptive statistics and Mann-Whitney U-test were utilized with SPSS for windows. Analysis of the data demonstrate that neither consumable costs nor operative time were significantly different in each group. Comparing operative costs, SILS appendicectomy, nephrectomy/heminephrectomy, and ovarian cystectomy/oophorectomy showed cost benefit over SLS (£397 versus £467; £942 versus £1127; £394 versus £495). A trend toward higher cost for SILS Palomo procedure is noted (£734 versus £400). Operative time for SILS appendicectomy, nephrectomy/heminephrectomy, and Palomo was lower compared to SLS (60 versus 103 minutes[mins.]; 130 versus 60 mins.; 60 versus 80 mins.). In conclusion, SILS appears to be cost-effective for the common pediatric surgical operations. There is no significant difference in operating time in this series, but small sample size is a limiting factor. Studies with larger numbers will be necessary to validate these initial observations.

  8. Endogenous Locus Reporter Assays.

    Science.gov (United States)

    Liu, Yaping; Hermes, Jeffrey; Li, Jing; Tudor, Matthew

    2018-01-01

    Reporter gene assays are widely used in high-throughput screening (HTS) to identify compounds that modulate gene expression. Traditionally a reporter gene assay is built by cloning an endogenous promoter sequence or synthetic response elements in the regulatory region of a reporter gene to monitor transcriptional activity of a specific biological process (exogenous reporter assay). In contrast, an endogenous locus reporter has a reporter gene inserted in the endogenous gene locus that allows the reporter gene to be expressed under the control of the same regulatory elements as the endogenous gene, thus more accurately reflecting the changes seen in the regulation of the actual gene. In this chapter, we introduce some of the considerations behind building a reporter gene assay for high-throughput compound screening and describe the methods we have utilized to establish 1536-well format endogenous locus reporter and exogenous reporter assays for the screening of compounds that modulate Myc pathway activity.

  9. Safety Assessment and Biological Effects of a New Cold Processed SilEmulsion for Dermatological Purpose

    Directory of Open Access Journals (Sweden)

    Sara Raposo

    2013-01-01

    Full Text Available It is of crucial importance to evaluate the safety profile of the ingredients used in dermatological emulsions. A suitable equilibrium between safety and efficacy is a pivotal concern before the marketing of a dermatological product. The aim was to assess the safety and biological effects of a new cold processed silicone-based emulsion (SilEmulsion. The hazard, exposure, and dose-response assessment were used to characterize the risk for each ingredient. EpiSkin assay and human repeat insult patch tests were performed to compare the theoretical safety assessment to in vitro and in vivo data. The efficacy of the SilEmulsion was studied using biophysical measurements in human volunteers during 21 days. According to the safety assessment of the ingredients, 1,5-pentanediol was an ingredient of special concern since its margin of safety was below the threshold of 100 (36.53. EpiSkin assay showed that the tissue viability after the application of the SilEmulsion was 92 ± 6% and, thus considered nonirritant to the skin. The human studies confirmed that the SilEmulsion was not a skin irritant and did not induce any sensitization on the volunteers, being safe for human use. Moreover, biological effects demonstrated that the SilEmulsion increased both the skin hydration and skin surface lipids.

  10. A Semicircular Incision in the Superior Umbilical Fold for SILS Preserves the Umbilical Profile

    Directory of Open Access Journals (Sweden)

    S. C. Blackburn

    2012-01-01

    Full Text Available Background. Single Incision Laparoscopic Surgery (SILS has been highlighted in the recent literature as a means of performing a range of common, minimal access, paediatric surgical procedures. The primary attraction is the absence of visible scarring. Aim. This study aims to describe a cosmetically advantageous means of SILS port placement in children, which preserves the umbilical profile. Methods. We describe a paediatric case series utilising a semicircular incision in the superior umbilical fold for SILS procedures. The linea alba is exposed over 2 cm just superior to the umbilical ring and stay sutures are applied. A vertical incision is made over this distance without entering the umbilical ring. Data were recorded prospectively in a Microsoft Excel database. Results. Twenty-one cases were performed in a 1-year period. Ten appendicectomies, 5 ovarian/paraovarian cystectomies, 2 Palomo procedures, 3 nephrectomy/heminephrectomies, and 1 Meckel’s diverticulectomy were performed. There was 1 wound infection. No incisional hernias occurred. Discussion. We believe that our technique, which maintains the integrity of the umbilical ring and allows preservation of the umbilical profile, offers a distinct cosmetic advantage over other incisions for SILS which distort it. Conclusion. We have demonstrated the aesthetic benefits of utilising a superior umbilical-fold incision for SILS in children.

  11. A Semicircular Incision in the Superior Umbilical Fold for SILS Preserves the Umbilical Profile.

    Science.gov (United States)

    Blackburn, S C; Adams, S D; Mahomed, A A

    2012-01-01

    Background. Single Incision Laparoscopic Surgery (SILS) has been highlighted in the recent literature as a means of performing a range of common, minimal access, paediatric surgical procedures. The primary attraction is the absence of visible scarring. Aim. This study aims to describe a cosmetically advantageous means of SILS port placement in children, which preserves the umbilical profile. Methods. We describe a paediatric case series utilising a semicircular incision in the superior umbilical fold for SILS procedures. The linea alba is exposed over 2 cm just superior to the umbilical ring and stay sutures are applied. A vertical incision is made over this distance without entering the umbilical ring. Data were recorded prospectively in a Microsoft Excel database. Results. Twenty-one cases were performed in a 1-year period. Ten appendicectomies, 5 ovarian/paraovarian cystectomies, 2 Palomo procedures, 3 nephrectomy/heminephrectomies, and 1 Meckel's diverticulectomy were performed. There was 1 wound infection. No incisional hernias occurred. Discussion. We believe that our technique, which maintains the integrity of the umbilical ring and allows preservation of the umbilical profile, offers a distinct cosmetic advantage over other incisions for SILS which distort it. Conclusion. We have demonstrated the aesthetic benefits of utilising a superior umbilical-fold incision for SILS in children.

  12. Adubação foliar com silício na cultura do milho

    Directory of Open Access Journals (Sweden)

    Lucas Barbosa de Freitas

    2011-04-01

    Full Text Available Inúmeros trabalhos têm demonstrado o efeito benéfico da adubação com silício sobre o acréscimo da produção de diversas culturas, como, por exemplo, arroz, cana-de-açúcar e batata. No entanto, são escassas as informações sobre os benefícios nutricionais do silício para a cultura do milho. Desta maneira, objetivou-se, neste estudo, avaliar o efeito de doses e épocas de aplicação de silício, via foliar, nas características agronômicas e na produtividade do milho, cultivado no ano agrícola 2007/2008. O delineamento experimental adotado foi o de blocos casualizados, em esquema fatorial (4 x 3 + 1, com quatro repetições, envolvendo doses de silício (130, 260, 390 e 520 g ha-1 de Si aplicadas via foliar, épocas de aplicação (2, 5 e 8 folhas expandidas e uma testemunha (sem aplicação de Si. As variáveis analisadas foram altura das plantas e a inserção da primeira espiga, diâmetro de colmo, índice de clorofila foliar, teor foliar de silício, número de grãos por espiga, massa de 100 grãos e produtividade de grãos. O silício aplicado via foliar influenciou somente o teor foliar de Si.

  13. Severidade de antracnose em folhas de sorgo submetido a doses crescentes de silício

    Directory of Open Access Journals (Sweden)

    Gil Rodrigues Santos

    Full Text Available A antracnose foliar é causada pelo fungo Colletotrichum sublineolum Hann. Kabát et Bub. (sin. C. graminicola (Ces. G.W. Wils. em plantas de sorgo podendo reduzir a produtividade de grãos e forragem, e o manejo adequado da nutrição mineral desta planta pode se apresentar como um mecanismo de controle sobre a antracnose. Dentre os minerais utilizados para o manejo de doenças, o silício destaca-se por reduzir a severidade das doenças em várias culturas. Diante do exposto, este trabalho teve por objetivo avaliar a severidade da antracnose em diferentes genótipos de sorgo suplementados com doses crescentes de silício. Para tal, realizaram-se experimentos em condições de casa de vegetação e de campo onde os genótipos de sorgo DOW 1F305 e A9735R foram suplementados com doses crescentes de silício (0; 500; 1.000; 1.500; 2.000; e 4.000 kg ha-1 e avaliados quanto à severidade da antracnose. Avaliou-se a severidade da doença por meio de uma escala de notas e, em seguida, amostras foram coletadas para determinação da concentração de silício nas folhas. Após a análise dos resultados, concluiu-se que houve redução na severidade da antracnose em resposta a adubação com silício para ambos os genótipos avaliados. Apesar do genótipo de sorgo DOW 1F305 acumular menores teores de silício em suas folhas, este genótipo foi mais resistente ao ataque da antracnose foliar.

  14. Evaluation of CP sil 8 film thickness for the capillary GC analysis of methyl mercury

    DEFF Research Database (Denmark)

    Petersen, Jens Højslev; Drabæk, Iver

    1992-01-01

    Different commercially available CP-Sil 8 CB capillary columns have been tested with a mixed standard containing methyl mercury chloride, ethyl mercury chloride and a stable nonpolar chlorinated hydrocarbon. The aim of the study was to see whether the columns tested could be used without special...... available insert for on-column injections on wide bore columns, and a 5.35 mum thick stationary phase. It was concluded that this CP Sil 8 CB column gave good results although minor interactions between the organo-mercury compounds and the column could be seen....

  15. Estudio comparativo entre los cuerpos silíceos de Bambusa y Guadua Estudio comparativo entre los cuerpos silíceos de Bambusa y Guadua

    Directory of Open Access Journals (Sweden)

    Londoño Ximena

    1991-12-01

    Full Text Available Se realiza un estudio anatómico comparativo de los cuerpos silíceos de la zona costal de la epidermis foliar entre Bambusa y Guadua, analizando 9 especies del género Bambusa y 8 especies del género Guadua. Se concluye que la forma no es un carácter diagnóstico que permita diferenciar los dos géneros mientras que el tamaño de los cuerpos silíceos y su distribución si lo son. An anatomical comparative study of silica bodies between Bambusa and Guadua is done.  Nine species of Bambusa and eight species of Guadua are analized. Size and distribution of the silica bodies rather than form can be used to distinguish both genera.

  16. Localization and analysis of error sources for the numerical SIL proof; Lokalisierung und Analyse von Fehlerquellen beim numerischen SIL-Nachweis

    Energy Technology Data Exchange (ETDEWEB)

    Duepont, D.; Litz, L. [Technische Univ. Kaiserslautern (Germany). Lehrstuhl fuer Automatisierungstechnik; Netter, P. [Infraserv GmbH und Co. Hoechst KG, Frankfurt am Main (Germany)

    2008-07-01

    According to the standard IEC 61511 each safety-related loop is assigned to one of the four Safety Integrity Levels (SILs). For every safety-related loop a SIL-specific Probability of Failure on Demand (PFD) must be proven. Usually, the PFD calculation is performed based upon the failure rates of each loop component aided by commercial software tools. However, this bottom-up approach suffers from many uncertainties. Especially, a lack of reliable failure rate data causes many problems. Reference data collected in different environments are available to solve this situation. However, this pragmatism leads to a PFD bandwidth, not to a single PFD value as desired. In order to make a decision for a numerical value appropriate for the chemical and pharmaceutical process industry a data ascertainment has been initiated by the European NAMUR. Its results display large deficiencies for the bottom-up approach. The error sources leading to this situation are located and analyzed. (orig.)

  17. Clinical significance of changes of serum levels of SIL-2R and CEA in patients with lung cancer after chemotherapy

    International Nuclear Information System (INIS)

    Rui Zhilian

    2004-01-01

    Objective: To investigate the changes of serum levels of SIL-2R and CEA after chemotherapy in patients with lung cancer. Methods: Serum levels of SIL-2R (with ELISA) and CEA (with RIA) were measured in 31 patients with lung cancer both before and after chemotherapy as well as in 35 cantrols. Results: Before chemotherapy, both serum SIL-2R and CEA levels in the patients were significantly higher than those in the controls (P 0.05), but the serum SIL-2R levels in the patients remained significantly higher than those in the controls (P<0.05). Conclusion: Determination of changes of serum SIL-2R and CEA levels after chemotherapy might be helpful for predicting the treatment outcomes in patients with lung cancer. (author)

  18. ÉTUDE DE CAS — Brésil : La contamination par le mercure en ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    11 janv. 2011 ... Leishmaniose : maladie sans frontières. Une mouche porteuse d'un parasite mortel hante la jungle des chutes d'Iguazu, qui marque la triple frontière entre le Brésil, l'Argentine et le. Voir davantageLeishmaniose : maladie sans frontières ...

  19. ÉTUDE DE CAS — Governador Valdares, Brésil : Le jardinage s ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    16 déc. 2010 ... À Governador Valadares, au Brésil, un programme municipal d'agriculture urbaine contribue à garnir la table des citadins des quartiers à faible revenu. Les protagonistes vont et viennent, mais les jardiniers tiennent bon, grâce à l'appui bien coordonné de nombreux acteurs locaux.

  20. Synergistic anti-tumor actions of luteolin and silibinin prevented cell migration and invasion and induced apoptosis in glioblastoma SNB19 cells and glioblastoma stem cells.

    Science.gov (United States)

    Chakrabarti, Mrinmay; Ray, Swapan K

    2015-12-10

    Glioblastoma is the most lethal brain tumor. Failure of conventional chemotherapies prompted the search for natural compounds for treatment of glioblastoma. Plant-derived flavonoids could be alternative medicine for inhibiting not only glioblastoma cells but also glioblastoma stem cells (GSC). Two plant-derived flavonoids are luteolin (LUT) and silibinin (SIL). We investigated anti-tumor mechanisms of LUT and SIL in different human glioblastoma cells and GSC and found significant synergistic inhibition of human glioblastoma LN18 and SNB19 cells and GSC following treatment with combination of 20µM LUT and 50µM SIL. Combination of 20µM LUT and 50µM SIL was more effective than a conventional chemotherapeutic agent (BCNU or TMZ). We continued our studies with SNB19 cells and GSC and found dramatic inhibition of cell migration from spheroids and also cell invasion through matrigel following treatment with combination of LUT and SIL. This combination was highly effective to block angiogenesis and survival pathways leading to induction of apoptosis. Inhibition of PKCα, XIAP, and iNOS ultimately caused induction of extrinsic and intrinsic pathways of apoptosis. Collectively, synergistic efficacy of LUT and SIL could be a promising therapy to inhibit cell migration and invasion and induce apoptosis in different glioblastoma cells including GSC. Copyright © 2015 Elsevier B.V. All rights reserved.

  1. La Petit Mort: uma possibilidade de materialização cénica sobre o silêncio

    OpenAIRE

    Martins, Joana Filipa Gomes

    2017-01-01

    A presente monografia é parte constituinte do meu Projeto Final de Mestrado em Teatro, especialização em Encenação e Interpretação, da ESMAE, cujo título é La Petite Mort – uma possibilidade de materialização cénica sobre o silêncio, que resulta num convite à reflexão sobre o silêncio. Nos dois primeiros capítulos, é realizado um enquadramento teórico sobre “o silêncio como tema” e sobre “o silêncio como ausência de som”, nos quais discorro sobre o contributo do cinema e de de practitioner...

  2. HybridSil Icephobic Nanocomposites for Next Generation Aircraft In-Flight Icing Measurement and Mitigation, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The purpose of this Phase I SBIR program is to adapt NanoSonic's HybridSil™ nanocomposites that combine high levels of erosion resistance and anti-icing...

  3. Highly Flexible, Fire Resistant HybridSil Foams for Next Generation Fireproofing, Insulation, and Energy Absorption NASA Applications, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The objective of this Phase I STTR program is to adapt NanoSonic's HybridSil™ nanocomposite technology for the creation of next generation highly flexible, fire...

  4. HybridSil Icephobic Nanocomposites for Next Generation Aircraft In-Flight Icing Measurement and Mitigation Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The purpose of this SBIR program is to adapt NanoSonic's HybridSil® nanocomposites and combine high erosion resistance, low ice adhesion, and passive anti-icing...

  5. HybridSil Icephobic Nanocomposites for Next Generation Aircraft In-Flight Icing Measurement and Mitigation, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — The purpose of this SBIR program is to adapt NanoSonic's HybridSil® nanocomposites and combine high erosion resistance, low ice adhesion, and passive anti-icing...

  6. SILWeb – analisador fonológico silábico-acentual de texto escrito

    Directory of Open Access Journals (Sweden)

    Ana Cristina Fricke Matte

    2012-11-01

    Full Text Available Este artigo apresenta o programa SilWeb – um programa analisador de texto escrito cuja finalidade é obter informações lexicais sobre acento e tipo de unidade fonológica –, e discute o processo de sua elaboração, cuja peculiaridade foi ser o resultado de uma interação entre lingüistas e engenheiros. Em função dessa interação, o processo contou com um estudo mattosiano da estrutura da transcrição fonológica adotada, bem como contou com o algoritmo do programa. Ambos os estudos estão relatados no presente artigo. Além da separação silábica tradicional, o programa possui uma versão para separação de unidades vogal avogal.

  7. O medo e o silêncio na ficção de Boris Schnaiderman

    Directory of Open Access Journals (Sweden)

    Ivone Gomes de Assis

    2014-05-01

    Full Text Available Este artigo aborda duas poéticas apresentadas em Guerra em surdina, de Boris Schnaiderman: o medo e o silêncio. Não se trata de uma condição isolada, mas, de experiências relatadas pelo personagem João Afonso, durante seu período de combate, na Segunda Guerra Mundial, na Itália

  8. No limite do silêncio: a cena mínima de Samuel Beckett

    Directory of Open Access Journals (Sweden)

    Fernando Mesquita de Faria

    2014-07-01

    Full Text Available http://dx.doi.org/10.5007/2176-8552.2013n16p133 O artigo pretende demonstrar, por reconhecimento, a apropriação do silêncio na dramaturgia de Samuel Beckett. As múltiplas funções e as possibilidades de articulação dramatúrgicas tornam o silêncio tão importante quanto os sons e seu estudo passa a ser essencial para compreendermos os aspectos sonoro-musicais que envolvem a obra do autor, sobretudo por virem associadas a uma linguagem verbal. A estrutura elíptica das suas peças, a exploração sonora de palavras e frases, a escassez de cenários e objetos cênicos, somados ao silêncio, podem produzir um efeito sinestésico no leitor/espectador e são indícios que nos levam a uma reflexão, servindo como álibi para melhor decifrarmos a obra beckettiana.

  9. SILS cholecystectomy, early experience of a single institution: pilot study of 21 cases.

    Science.gov (United States)

    Ruffo, G; Barugola, G; Scopelliti, F; Sartori, A; Crippa, S; Partelli, S; Falconi, M

    2012-06-01

    Many surgeons have attempted to reduce the number and the size of ports in laparoscopic cholecystectomy to decrease parietal trauma and pain, and to improve cosmetic results. We report a series of laparoscopic cholecystectomies using a single-port technique (SILS) through an umbilical incision in a pilot group of 21 cases. Our goal was to validate and develop the single-port access as a viable option. All the operations were performed using an umbilical SILS port (Ethicon). Most reported techniques utilize special purpose-made instruments. This article provides a stepwise description of the procedure using all straight instruments. No special reticulating instruments or flexible telescopes were used. We report our early difficulties and concerns about the procedure and propose solutions to the problems. Patients' request for improved cosmesis impels surgeons toward the application of SILS, but the true advantage of the technique should be assessed by more evidences. For this reason, we are planning a single-institution, prospective randomized controlled trial to compare postoperative pain, operating time and cosmetic result between one port and standard laparoscopic surgery.

  10. Índices de crescimento de Brachiaria brizantha cv. Marandu adubadas com fontes e doses de silício

    Directory of Open Access Journals (Sweden)

    Kathery Brennecke

    2013-12-01

    Full Text Available Oobjetivo do experimento foi avaliar características morfométricas de Brachiaria brizantha cv. Maranduadubadas com fontes de silício orgânico e inorgânico e doses representativas à 0, 100, 150, 200 e 250 kg.ha-1.O delineamento utilizado foi de parcelas sub-divididas em um fatorial de 2 x 5x 5 (fontes de silício x doses de silício x repetições. Foram avaliados comprimentofinal de folhas e colmo, taxa de alongamento foliar e de colmo e intervalo de aparecimento foliar. Ocomprimento final das folhas foi significativo em função das fontes de silícioutilizadas, porém observam-se diferenças (p<0,01 a partir da quarta folha.Na taxa de alongamento foliar, assim como no intervalo de aparecimento foliar,e taxa de aparecimento foliar não apresentaram diferenças estatísticassignificativas quando estudado as fontes de silício nem quando estudado asdoses, o mesmo ocorrendo para o alongamento de colmo e o tamanho final decolmo. Conclui-se que tanto as fontes como as doses de silício não diferiramentre si e não influenciaram as medidas morfofisiológicas do capim-Marandu.

  11. A SIL quantification approach based on an operating situation model for safety evaluation in complex guided transportation systems

    International Nuclear Information System (INIS)

    Beugin, J.; Renaux, D.; Cauffriez, L.

    2007-01-01

    Safety analysis in guided transportation systems is essential to avoid rare but potentially catastrophic accidents. This article presents a quantitative probabilistic model that integrates Safety Integrity Levels (SIL) for evaluating the safety of such systems. The standardized SIL indicator allows the safety requirements of each safety subsystem, function and/or piece of equipment to be specified, making SILs pivotal parameters in safety evaluation. However, different interpretations of SIL exist, and faced with the complexity of guided transportation systems, the current SIL allocation methods are inadequate for the task of safety assessment. To remedy these problems, the model developed in this paper seeks to verify, during the design phase of guided transportation system, whether or not the safety specifications established by the transport authorities allow the overall safety target to be attained (i.e., if the SIL allocated to the different safety functions are sufficient to ensure the required level of safety). To meet this objective, the model is based both on the operating situation concept and on Monte Carlo simulation. The former allows safety systems to be formalized and their dynamics to be analyzed in order to show the evolution of the system in time and space, and the latter make it possible to perform probabilistic calculations based on the scenario structure obtained

  12. DCS innovation by SIL and non-SIL unified architecture - Hitachi approach on G-HIACS (R800FS/R900)

    International Nuclear Information System (INIS)

    Horikoshi, Y.; Shimizu, T.; Otsuka, Y.; Suenaga, M.; Masunaga, S.

    2012-01-01

    In response to the demand for safe, secure and smart systems, Hitachi, Ltd. has been developing a new generation of DCS, the Global-Hitachi Integrated Autonomous Control System ('G-HIACS'), based on its highly successful HIACS-7000 architecture. The G-HIACS product family comprises the SIL2-rated R800FS/HSC800FS vSAFE (pronounced 'nu-safe') Functional Safety Controller and the R900/HSC900 General Purpose Controller. This paper summarizes the ongoing technical development successes, presents the key results of Hitachi activities within the Canadian nuclear market, and maps out our medium-term goal of fully integrating the two platforms into a harmonized architecture (the G-HIACS 'Unified Architecture'). (author)

  13. Pobreza y Locus de Control

    Directory of Open Access Journals (Sweden)

    Joaquina Palomar Lever

    2004-01-01

    Full Text Available En este trabajo se busco conocer si existen diferencias en el locus de control según el nivel de pobreza en una población de 900 personas clasificadas en tres grupos: pobres extremos, pobres moderados y no pobres. Los sujetos estudiados compartieron la característica de ser personas económicamente independientes. Para este estudio se utilizaron como instrumentos de medición, un cuestionario sociodemográfico y una escala de locus de control. Los resultados muestran que los grupos de mayor ingreso familiar así como el grupo de no pobres y el de pobres moderados presentan en mayor medida un locus de control interno, mientras que el grupo de pobres extremos un mayor locus de control externo; por otro lado se observó que las personas de sexo masculino así como los de más edad (36 a 72 años presentan un locus de control más interno que aquellas personas de sexo femenino y de menor edad (19 a 35 años. Además, las personas con mayor nivel educativo (licenciatura y postgrado presentan una mayor tendencia hacia la internalidad en comparación con las personas de menor nivel educativo (sin escolaridad, primaria, secundaria y preparatoria. A su vez, se observó que la escolaridad de los padres influye en el locus de control. En términos generales, las variables que mejor predicen el locus de control fueron el ingreso familiar y la escolaridad de los sujetos

  14. Sil: a Streptococcus iniae bacteriocin with dual role as an antimicrobial and an immunomodulator that inhibits innate immune response and promotes S. iniae infection.

    Directory of Open Access Journals (Sweden)

    Mo-fei Li

    Full Text Available Streptococcus iniae is a Gram-positive bacterium and a severe pathogen to a wide range of economically important fish species. In addition, S. iniae is also a zoonotic pathogen and can cause serious infections in humans. In this study, we identified from a pathogenic S. iniae strain a putative bacteriocin, Sil, and examined its biological activity. Sil is composed of 101 amino acid residues and shares 35.6% overall sequence identity with the lactococcin 972 of Lactococcus lactis. Immunoblot analysis showed that Sil was secreted by S. iniae into the extracellular milieu. Purified recombinant Sil (rSil exhibited a dose-dependent inhibitory effect on the growth of Bacillus subtilis but had no impact on the growths of other 16 Gram-positive bacteria and 10 Gram-negative bacteria representing 23 different bacterial species. Treatment of rSil by heating at 50°C abolished the activity of rSil. rSil bound to the surface of B. subtilis but induced no killing of the target cells. Cellular study revealed that rSil interacted with turbot (Scophthalmus maximus head kidney monocytes and inhibited the innate immune response of the cells, which led to enhanced cellular infection of S. iniae. Antibody blocking of the extracellular Sil produced by S. iniae significantly attenuated the infectivity of S. iniae. Consistent with these in vitro observations, in vivo study showed that administration of turbot with rSil prior to S. iniae infection significantly increased bacterial dissemination and colonization in fish tissues. Taken together, these results indicate that Sil is a novel virulence-associated bacteriostatic and an immunoregulator that promotes S. iniae infection by impairing the immune defense of host fish.

  15. O silêncio, ainda? O desejo de nada, um fantasma, ainda

    Directory of Open Access Journals (Sweden)

    Davi Carneiro Pessoa

    2012-09-01

    Full Text Available http://dx.doi.org/10.5007/2176-8552.2011nesp2p123 Este artigo discute a estética negativa presente nas narrativas de Samuel Beckett, Molloy (1951, Malone meurt (1951 e L’Innommable (1953, com o intuito de pensar, ao mesmo tempo, a memória e o esquecimento, o ruído e o silêncio, pois a partir dessas relações podemos pensar o fracasso da escritura como potência.

  16. Futebol et hiérarchies urbaines au Brésil.

    Directory of Open Access Journals (Sweden)

    Hervé Théry

    2006-03-01

    Full Text Available Le football n’est pas seulement la passion nationale du Brésil, il peut être aussi un bon indicateur des hiérarchies urbaines du pays. Les classements disponibles sur le site de la fédération brésilienne de futebol peuvent être mis en rapport avec d’autres données pour vérifier la corrélation entre les performances sportives des clubs et le degré de centralité des villes où ils sont basés.

  17. Novel SIL1 mutations cause cerebellar ataxia and atrophy in a French-Canadian family.

    Science.gov (United States)

    Noreau, Anne; La Piana, Roberta; Marcoux, Camille; Dion, Patrick A; Brais, Bernard; Bernard, Geneviève; Rouleau, Guy A

    2015-10-01

    Two French-Canadian sibs with cerebellar ataxia and dysarthria were seen in our neurogenetics clinic. The older brother had global developmental delay and spastic paraplegia. Brain MRIs from these two affected individuals showed moderate to severe cerebellar atrophy. To identify the genetic basis for their disease, we conducted a whole exome sequencing (WES) investigation using genomic DNA prepared from the affected sibs and their healthy father. We identified two mutations in the SIL1 gene, which is reported to cause Marinesco-Sjögren syndrome. This study emphasizes how the diagnosis of patients with ataxic gait and cerebellar atrophy may benefit from WES to identify the genetic cause of their condition.

  18. Aprovechamientos hidroeléctricos en el tramo superior del río Sil

    Directory of Open Access Journals (Sweden)

    Enrique Sánchez Conde

    2017-05-01

    Full Text Available En este trabajo se describen los tres aprovechamientos hidroeléctricos, denominados Ondinas, Peñadrada y Santa Marina, dispuestos en rosario, que se extienden en el tramo superior del río Sil. Estas obras serán construidas y explotadas por la Compañía Hidroeléctrica de Galicia, empresa filial del Instituto Nacional de Industria. El salto de Santa Marina, llamado también número 1 de este sistema ternario, presenta la particularidad de tener su Central en subterráneo.

  19. Pobreza y Locus de Control

    OpenAIRE

    Joaquina Palomar Lever; Laura M. Valdés Trejo

    2004-01-01

    En este trabajo se busco conocer si existen diferencias en el locus de control según el nivel de pobreza en una población de 900 personas clasificadas en tres grupos: pobres extremos, pobres moderados y no pobres. Los sujetos estudiados compartieron la característica de ser personas económicamente independientes. Para este estudio se utilizaron como instrumentos de medición, un cuestionario sociodemográfico y una escala de locus de control. Los resultados muestran que los grupos d...

  20. Silêncio nas organizações: uma revisão e discussão da literatura.

    Directory of Open Access Journals (Sweden)

    Marcos Júnior de Moura-Paula

    2014-10-01

    Full Text Available O objetivo deste trabalho é apresentar como o silêncio tem sido estudado por pesquisadores de gestão ou áreas afins (como psicologia ou comunicação organizacionais. Ignorado por longo tempo, o silêncio emerge como uma área frutífera de pesquisa devido a diversas consequências que ele pode causar para os empregados (estresse, angústia, baixa autoestima e dissonância cognitiva, para as organizações (absenteísmo, maior rotatividade, baixa produtividade e para a sociedade (não denúncia de ilegalidades cometidas pelas organizações. Faz-se um levantamento bibliográfico com base na divisão em três ondas de pesquisa sobre a evolução dos estudos de voz e silêncio nas organizações baseado em Brinsfield, Edwards e Greenberg (2009, com foco no silêncio. Da primeira onda (1970-1980 são apresentados: o conceito de voz e a subsunção do silêncio ao conceito de lealdade; as “espirais de silêncio” e o “efeito mudo” (MUM effect. Da segunda onda (1980-2000: a “denúncia de irregularidades organizacionais” (whistleblowing; a “discordância organizacional baseada em princípios” (principled organizational dissent; a justiça organizacional; a “promoção de questões” (issue selling; a cidadania organizacional; o ostracismo social e a “síndrome do surdo” (deaf-ear syndrome. Da terceira onda (2000 em diante: o silêncio organizacional; o silêncio dos empregados; retirada do trabalho (job withdrawal; aprendizagem organizacional e transferência de conhecimento. Observou-se que as pesquisas, principalmente no caso da terceira onda, têm evoluído de pesquisas conceituais e qualitativas para pesquisas quantitativas, havendo questionamentos de alguns pesquisadores sobre a necessidade de se utilizar outras abordagens teórico-metodológicas além das de inspiração positivista. A pesquisa brasileira sobre silêncio, apesar do pequeno volume, contribui para a compreensão do fenômeno na medida em que se insere na

  1. The clinical significance of T-cells, sIL-2R and TNF in evaluating patients with splenic autotransplantation

    International Nuclear Information System (INIS)

    Wang Haowei; Wu Haorong; Li Juncheng; Wu Jingchang

    2002-01-01

    To study the immunological effects of splenic autotransplantation, forty patients with splenic trauma were divided into two groups equally. One group underwent splenic autotransplantation and another underwent splenectomy. Control group included ten cases. Splenic autotransplantation and splenectomy group were compared with the control group. In the group of splenic autotransplantation, CD3 + , CD4 + , CD8 + , CD4 + /CD8 + dropped and sIL-2R, TNF rose after a week of operation. Then CD3 + , CD4 + , CD8 + , CD4 + /CD8 + rose and sIL-2R, TNF dropped three months later. In the group of splenectomy, CD 3+ , CD4 + , CD8 + and CD4 + /CD8 + dropped persistently, while sIL-2R and TNF rose postoperatively. Result showed splenic autotransplantation can help body to maintain T-cells level and improve the anti-infective ability

  2. Invasive Species

    Science.gov (United States)

    Invasive species have significantly changed the Great Lakes ecosystem. An invasive species is a plant or animal that is not native to an ecosystem, and whose introduction is likely to cause economic, human health, or environmental damage.

  3. Locus of Control and Obesity

    Directory of Open Access Journals (Sweden)

    Florence eNeymotin

    2014-10-01

    Full Text Available In the developed world, the hazards associated with obesity have largely outstripped the risk of starvation. Obesity remains a difficult public health issue to address, due in large part to the many disciplines involved. A full understanding requires knowledge in the fields of genetics, endocrinology, psychology, sociology, economics, and public policy – among others. In this short review, which serves as an introduction to the Frontiers in Endocrinology research topic, we address one cross-disciplinary relationship: the interaction between the hunger/satiation neural circuitry, an individual’s perceived locus of control, and the risk for obesity. Mammals have evolved a complex system for modulating energy intake. Overlaid on this, in humans, there exists a wide variation in perceived locus of control – that is, the extent to which an individual believes to be in charge of the events that affect them. Whether one has primarily an internal or external locus of control itself affects, and is affected by, external and physiological factors and has been correlated with the risk for obesity. Thus, the path from hunger and satiation to an individual’s actual behavior may often be moderated by psychological factors, included among which is locus of control.

  4. Locus of control and obesity.

    Science.gov (United States)

    Neymotin, Florence; Nemzer, Louis R

    2014-01-01

    In the developed world, the hazards associated with obesity have largely outstripped the risk of starvation. Obesity remains a difficult public health issue to address, due in large part to the many disciplines involved. A full understanding requires knowledge in the fields of genetics, endocrinology, psychology, sociology, economics, and public policy - among others. In this short review, which serves as an introduction to the Frontiers in Endocrinology research topic, we address one cross-disciplinary relationship: the interaction between the hunger/satiation neural circuitry, an individual's perceived locus of control, and the risk for obesity. Mammals have evolved a complex system for modulating energy intake. Overlaid on this, in humans, there exists a wide variation in "perceived locus of control" - that is, the extent to which an individual believes to be in charge of the events that affect them. Whether one has primarily an internal or external locus of control itself affects, and is affected by, external and physiological factors and has been correlated with the risk for obesity. Thus, the path from hunger and satiation to an individual's actual behavior may often be moderated by psychological factors, included among which is locus of control.

  5. A Profilaxia do Silêncio: Nietzsche e a Virtude da Vita Contemplativa

    Directory of Open Access Journals (Sweden)

    Jelson Roberto Oliveira

    2011-12-01

    Full Text Available http://dx.doi.org/10.5007/1677-2954.2011v10n1p133 Pretende-se mostrar como o tema do silêncio, apresentado como parte do projeto nietzscheano de revitalização da vita contemplativa, adquire importância no chamado segundo período de sua produção, ligado àquela que poderia ser considerada a primeira e mais contundente das virtudes humanas apontadas por Nietzsche: o cultivo de si. Nesse sentido, trata-se de uma noção requisitada como parte do projeto crítico da modernidade implementado pelo filósofo alemão, cujo ponto de partida é uma revisão da própria tarefa da filosofia, conduzindo a uma crítica radical da moralidade vigente, da hipertrofia da racionalidade e da importância da linguagem. O silêncio, associado à solidão, aparece como uma profilaxia e radical aprofundamento em relação à anulação de si no arrulho da multidão moderna.

  6. Desenvolvimento e fitossanidade de ameixeiras tratadas com silício em sistema orgânico

    OpenAIRE

    Ferreira, Silvana Girotto Martins; Botelho, Renato Vasconcelos; Faria, Cacilda Márcia Duarte Rios; Mateus, Milena Aparecida Ferrari; Zaluski, Welton Luiz

    2013-01-01

    O objetivo deste trabalho foi avaliar o efeito do silício (Si) aplicado via pulverização foliar em ameixeiras cv. Pluma 7, para o controle da bacteriose (Xanthomonas arborícola pv. pruni), mariposa oriental (Grapholita molesta) e pulgão-verde (Myzus persicae), bem como no desenvolvimento das plantas, em sistema orgânico de produção. Para o ensaio, foi utilizado o produto comercial AgriSil® (98% de SiO2). O experimento foi conduzido em Guarapuava-PR, durante dois ciclos consecutivos (2010/2011...

  7. Differentiated squamous intraepithelial lesion (dSIL)-like changes in the epidermis overlying anogenital melanocytic nevi: A diagnostic pitfall.

    Science.gov (United States)

    Michalova, Kvetoslava; Kazakov, Dmitry V; Michal, Michael; Hadravsky, Ladislav; Kacerovska, Denisa; Rychly, Boris; Miesbauerova, Marketa; Michal, Michal

    2017-02-01

    Differentiated squamous intraepithelial lesion (dSIL) is morphologically and immunohistochemically analogous in the whole anogenital region. dSIL is a premalignant lesion frequently misinterpreted histopathologically as a benign dermatosis. The authors describe a peculiar change in the basal cell layer of the epidermis/epithelium overlying anogenital melanocytic nevi that may histopathologically imitate dSIL. The aim of this study is to familiarize the pathologists with this pitfall to avoid its possible overdiagnosis as dysplasia. Further, we tried to explore the biological characteristics of the dSIL-like changes and to focus on the differential diagnostic aspects. Seventy cases of anogenital nevi were retrieved from our registry. All cases were stained with hematoxylin and eosin (H&E) and reviewed. Cases in which the epidermis overlying nevi featured atypical appearing basal keratinocytes in otherwise fully differentiated epithelium, variable degrees of acanthosis and parakeratosis were selected for additional investigation. Thirty cases meeting the above described criteria were identified. The patients were 8 males and 22 females, with age at the time of diagnosis ranging from 4 to 68years. Follow-up data were available for 28 patients (range 0.5-19years, mean 5.1), and to date, no signs of epithelial malignancy have been recorded. Immunohistochemically (IHC), the epidermis overlying nevi showed insignificant positivity for p53 in all tested cases. Melanocytic markers (S-100 protein, SOX10, Melan A) and cytokeratin AE1/3 labeled melanocytes and keratinocytes, respectively, enabling their distinction, especially in nevi featuring a junctional component. Differentiated squamous intraepithelial lesion-like changes seem to occur relatively often in the epidermis overlying anogenital melanocytic nevi. Since morphologically they are virtually identical to the "true" dSIL, their distinction largely depends on p53 expression in basal keratinocytes with normal p53

  8. Uterine Healing after Therapeutic Intrauterine Administration of TachoSil (Hemostatic Fleece in Cesarean Section with Postpartum Hemorrhage Caused by Placenta Previa

    Directory of Open Access Journals (Sweden)

    Katrine Fuglsang

    2012-01-01

    Full Text Available Background. Application of hemostatic fleece (TachoSil directly onto the bleeding surfaces of the lower uterine segment has been used to obtain hemostasis during cesarean section caused by placenta previa. Methods. Eleven of 15 patients treated with TachoSil for excessive postpartum haemorrhage due to placenta previa were enrolled. An evaluation of the cesarean section scar by transvaginal ultrasound, the uterine cavity and endometrium by hysteroscopy, and the endometrium by biopsy were made. The main outcome measures were intrauterine adhesions, recovery of endometrium at the site of TachoSil application, visible remnants of TachoSil, and scar healing. Results. Eight patients had small remnants of TachoSil in the uterine cavity together with signs of resorption. All had a normal endometrial mucosa, and none had adhesions in the uterine cavity. All cesarean section scars were healed without defects. Conclusion. TachoSil did not seem to impair healing of the endometrium or scar formation in the uterus after intrauterine application. Resorption of TachoSil seems to progress individually. Intrauterine treatment with TachoSil is a valuable supplement to the traditional treatment of post partum haemorrhage and may help retain reproductive capability. This is a small study, and it will require more studies to confirm the reproducibility.

  9. Locus of control in graduation students

    OpenAIRE

    Haider Zaidi, Imran; MS (Clinical Psychology) Scholar G.C University, Faisalabad, Pakistan; Mohsin, M. Naeem; Director Distance Learning Education G.C University, Faisalabad, Pakistan

    2013-01-01

    The current research focused on exploring the direction of Locus of control as well as gender difference on locus of control among graduation students in Pakistan. A 29 item Locus of Control questionnaire (Rotter, 1966) was used to measure locus of control. Sample of (N=200) individuals (n=100) men and (n=100) women selected from different academic institutes of Faisalabad division Punjab Pakistan. Independent sample t-test was used for statistical analysis. This study has consistent results ...

  10. A Retórica do silêncio The rhetoric of silence

    Directory of Open Access Journals (Sweden)

    Cesar Marino Villavicencio

    2011-12-01

    Full Text Available A teoria da retórica na música barroca revela-se, de modo geral, interpretativa e heterogênea, não havendo uma linha de pensamento fixa. Essa heterogeneidade torna-se evidente quando se analisa a utilização dos silêncios como figuras retóricas. Para definir as intencionalidades dos silêncios é necessário considerar os afetos que os cercam. Assim, por haver diversos afetos inerentes, há ainda mais deliberações subjetivas na análise dos silêncios. Sugerindo uma visão retórica plural, propõe-se diversos tipos de categorização bem como a coexistência de interpretações. Para apresentar os desdobramentos dos objetivos estéticos da meraviglia, que focam o escopo pragmático de deslumbrar inesperadamente criando percepções chocantes de admiração, busca-se um equilíbrio entre a teoria e a prática através de exemplificações musicais. A retórica é vista como a energia inerente na emoção e no pensamento, transmitida por meio de um sistema de signos, entre os quais a música, com o objetivo de influenciar terceiros em suas decisões e ações.There is a lack of a single doctrine for the use of rhetoric in baroque music. The rhetorical theory has interpretative and heterogeneous qualities. Musical silences are among the rhetorical figures of the baroque. To frame the intentionalities of silences it is necessary to consider the affects that surround them. This means that to describe silences we are even more subjected to a variety of interpretations. In favor of a pluralistic view of rhetoric, embracing a diversity of categorizations is suggested. In order to reveal some of the aesthetic objectives of the meraviglia, which are focused on provoking a shocking sense of wonderment through creating experiences that astonish with delight, musical examples of the pathetic use of silences are presented. Rhetoric is viewed as the energy inherent in emotion and thought, transmitted through a system of signs, including music, to

  11. Ácidos silícicos como catalizadores y fuente de silicio/metal para zeolitas

    OpenAIRE

    Barea Berzosa, Eva María

    2008-01-01

    Barea Berzosa, EM. (2005). Ácidos silícicos como catalizadores y fuente de silicio/metal para zeolitas [Tesis doctoral no publicada]. Universitat Politècnica de València. doi:10.4995/Thesis/10251/1868.

  12. Efficacy and safety of TachoSil® versus standard treatment of air leakage after pulmonary lobectomy

    DEFF Research Database (Denmark)

    Marta, Gabriel Mihai; Facciolo, Francesco; Ladegaard, Lars

    2010-01-01

    Alveolar air leakage remains a serious problem in lung surgery, being associated with increased postoperative morbidity, prolonged hospital stay and greater health-care costs. The aim of this study was to evaluate the sealing efficacy and safety of the surgical patch, TachoSil®, in lung surgery....

  13. Interdito e silêncio: uma abordagem no quadrado das oposições

    Directory of Open Access Journals (Sweden)

    Fabio Elias Verdiani Tfouni

    2010-03-01

    Full Text Available O presente trabalho, situado no campo da análise do discurso de Pêcheux, numainterface com a psicanálise, trata o interdito e o silêncio como constitutivos efundadores do discurso. Resumidamente, afirmamos que para que seja possívelque se diga algo é preciso que não se diga tudo. Fazemos uma abordagemdessas questões com base nas modalidades aléticas da lógica aristotélica. Paratal tarefa, tratamos a questão do dizer a partir do quadrado lógico aristotélico.Propusemos e construímos um quadrado do dito e da enunciação.

  14. Single-Incision Laparoscopic Surgery (SILS Assisted Sigma Resection Via Pfannenstiel Incision for Complicated Diverticulitis

    Directory of Open Access Journals (Sweden)

    Arne Dietrich

    2014-02-01

    Results: The operation time ranged from 89 to 280 min. There were no conversions, and no additional trocars were used. The postoperative hospital stay ranged from 5 to 14 days. All patients were discharged without any intraoperative or postoperative complications. Conclusions: SILS sigma or anterior rectum resection for complicated diverticulitis can be performed via a Pfannenstiel incision. This approach provides direct visualization and access into the pelvis as well as the option to benefit from open surgery devices. The Pfannenstiel incision may generally be recommended for the favorable cosmetic effect and the very low rate of incisional hernias, as reported in the literature. [Arch Clin Exp Surg 2014; 3(1.000: 10-15

  15. El elefante fósil de Buelna (Asturias. Nota preliminar

    Directory of Open Access Journals (Sweden)

    Mazo, A. V.

    1998-12-01

    Full Text Available An elephant fossil was found in a cave close to Buena (Asturias, Spain. It was identified as Elephas antiquus (Falconer & Cautley. This initial study is based on the morphological and metrical characteristics of a femur and an hemipelvis. These fossil remains belong to a grown-up quite complete animal which is still waiting for its extraction. According to chronology, we allocate this finding to the last interglacial period.Un elefante fósil encontrado en una cueva próxima a Buena (Asturias se identifica como Elephas antiquus (Falconer & Cautley. Este estudio preliminar se basa en las características morfológicas y métricas de un fémur y una hemipelvis; restos que forman parte de un individuo adulto bastante completo que aún permanece sin extraer. Cronológicamente, atribuimos este hallazgo al último interglacial.

  16. Locus of Control and Anxiety as Mediating Variables of Locus of Conflict in Disadvantaged Youth.

    Science.gov (United States)

    Ollendick, Duane G.

    1979-01-01

    As hypothesized, external locus of control scores correlated significantly with locus of conflict scores, although this varied for both sex and for the type of behavior problems exhibited. The hypothesized relationship between anxiety and locus of conflict was not supported. (RL)

  17. Clinical significance of the changes of serum IL-2, SIL-2R and VEGF levels in pediatric patients with pulmonary tuberculosis

    International Nuclear Information System (INIS)

    Zeng Dongliang; Wu Chunfeng; Jiang Huanhao

    2005-01-01

    Objective: To explore the clinical significance of the changes of serum IL-2, soluble IL-2 receptor (SIL-2R) and vascular endothelial growth factor (VEGF) levels in pediatric patients with tuberculosis. Methods: Serum IL-2 (with RIA) and SIL-2R, VEGF (with ELISA) levels were determined in 68 pediatric patients with tuberculosis (30 active and 38 non- active) and 30 controls. Results: In the patients with active tuberculosis, the serum IL-2 levels were significantly lower and SIL-2R, VEGF levels were significantly higher than those in the controls (P<0.01). Conclusion: Determination of serum IL-2, SIL-2R and VEGF levels was useful for monitoring the activity of tuberculosis in pediatric patients. (authors)

  18. Clinical significance of determination of changes of serum IL-2, SIL-2R, TNF-α contents and T-cell subgroup distribution type in patients with psoriasis

    International Nuclear Information System (INIS)

    Mou Xudong

    2005-01-01

    Objective: To investigate the changes of serum IL-2, SIL-2R, TNF-α contents and T-cell subgroup distribution type in patients with psoriasis. Methods: Serum IL-2 and TNF-α levels were measured with RIA, SIL-2R levels was measured with ELISA and T-cell subgroup distribution type was detected with monoclonal antibody in 40 patients with psoriasis and 35 controls. Results: The serum IL-2 levels and CD 4 /CD 8 values were significantly lower in the patients than those in controls (P<0.01), while the serum SIL-2R, TNF-α levels were significantly higher (P<0.01). Conclusion: Determination of serum IL-2, SIL-2R, TNF-α contents and T-cell subgroup distribution type is clinically useful for understanding the disturbances of immuno-modulation in these patients. (authors)

  19. Caracterización y significado de las rocas silíceas y ferruginosas del Paleoceno de Zamora

    OpenAIRE

    Bustillo, Mª Ángeles; Martín Serrano, Ángel

    1980-01-01

    Se estudian las rocas silíceas y ferruginosas del Paleógeno de la provincia de Zamora dentro del contexto general de la sedimentación fluvial. El análisis detallado de las muestras es realizado por técnicas petrográficas en lámina delgada y probeta pulida, determinando además su composición mineralógica por difracción de Rayos X. Los minerales silíceos detectados son ópalo C y ópalo C-T mientras que como minerales de hierro aparecen hidróxidos amorfos, hematites y goetita. Las conclusiones...

  20. Systèmes d'innovation des pays BRICS (Brésil, Russie, Inde, Chine ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le Brésil, la Russie, l'Inde, la Chine et l'Afrique du Sud (dits pays BRICS) ont placé l'innovation au coeur de leur stratégie de développement. Toutefois, les ... IDRC is investing in local solutions to address climate change-related challenges in India, including heat stress, water management, and climate-related migration.

  1. The association of novel IL-33 polymorphisms with sIL-33 and risk of systemic lupus erythematosus.

    Science.gov (United States)

    Guo, Jing; Xiang, Yang; Peng, You-Fan; Huang, Hua-Tuo; Lan, Yan; Wei, Ye-Sheng

    2016-09-01

    The serum level of IL-33 was upregulated in systemic lupus erythematosus (SLE), which may be used as biomarkers and/or therapeutic targets for SLE. The aim of this study was to investigate the association of four novel polymorphisms of IL-33 with risk of SLE. The study population comprised 540 Chinese individuals, including 257subjects with SLE and 283 healthy controls. The gene polymorphism was measured using Snapshot SNP genotyping assays and confirmed by sequencing. Serum IL-33 (sIL-33) levels were measured by ELISA. The serum SLE levels were significantly higher in the group of patients with SLE than those in the control group (Prisk of SLE as compared with the rs1891385 A allele (OR=1.405, 95% CI, 1.052-1.875, P=0.021). The C-T-T-G haplotype was significantly increased the risk of SLE (OR=1.411; 95% CI, 1.021-1.948; P=0.036). IL-33 gene rs1891385 polymorphism was significantly associated with the expression of sIL-33 in the SLE patients. Besides, in our study, we found that the unregulated sIL-33 level was significantly associated with the abnormal changed CRP and ESR. This is the first study reporting the IL-33 gene polymorphisms and SLE, which may help refine the SLE risk profile. Copyright © 2016 Elsevier Ltd. All rights reserved.

  2. Study on the diagnostic value of combined determination of serum CA125, CA199 and SIL-2R levels in patients with endometriosis

    International Nuclear Information System (INIS)

    Yang Jingxiu; Shi Shaohong; Wang Yuping; Xie Xueqin; Qin Jibao

    2005-01-01

    Objective: To investigate the diagnostic values of combined determination of serum CA125, CA199 and SIL-2R levels in patients with endometriosis. Methods: Serum CA125, CA199 were measured with RIA and SIL-2R levels with ELISA in 54 patients with endometriosis and 35 controls. Results: The serum levels of CA125, CA199 and SIL-2R in patients with endometriosis were significantly higher than those in controls (P<0.01). The sensitivity and speciality of CA125 for endometriosis was 70.2% and 80.4% respectively, the sensitivity and speciality of CA199 for endometriosis was 62.4% and 71.8% respectively, the sensitivity and speciality of SIL-2R was 89.5% and 60.2% respectively. The sensitivity of the combined determination of CA125, CA199 and SIL-2R for endometriosis was 86.8% being significantly higher than that of CA125 and CA199 respectively. Conclusion: Combined determination of the serum CA125, CA199 and SIL-2R levels in serum can increase the diagnostic sensitivity for endometriosis. (authors)

  3. A case-control study of human papillomavirus and cervical squamous intraepithelial lesions (SIL in Harris County, Texas: differences among racial/ethnic groups

    Directory of Open Access Journals (Sweden)

    Tortolero-Luna Guillermo

    1998-01-01

    Full Text Available We conducted a case-control study of the association between SIL and HPV among whites (W, African Americans (AA, and Hispanics (H in Harris County, Texas. Cases were identified at M.D. Anderson Cancer Center Colposcopy Clinic. Controls were identified among women obtaining routine Pap screening at two Harris County Health Department Clinics. HPV was detected by a PCR-based fluorescent assay. Dichotomous and polytomous logistic regression models were used to estimate adjusted odd ratios (AOR and 95% confidence intervals (CI for SIL among racial/ethnic groups and grade of disease. Prevalence of HPV infection was 64% in low grade SIL (LSIL, 84% in high grade SIL (HSIL, and 19% in controls. Risk of SIL was higher in H than in W and AA, AOR 29.5 (12.4-70.5, 15.3 (6.0-33.8, and 5.8 (2.6-12.6, respectively. Similarly, racial/ethnic differences were observed for both LSIL (AOR = 16.6, 7.7, and 4.3, respectively and HSIL (AOR = 78.6, 34.6, and 14.2, respectively. Findings support the association between SIL and HPV and differences in the strength of the association with LSILs and HSILs. Data also suggest a higher risk for H and a lower risk for AA.

  4. Do silêncio à vertigem: a escrita autobiográfica de Herzer

    Directory of Open Access Journals (Sweden)

    Marcus Rogério Salgado

    2016-12-01

    Full Text Available Publicado em 1982, A queda para o alto é, no âmbito da literatura brasileira, obra pioneira escrita por autor transexual. Nascida Sandra Mara Herzer, passaria a adotar o nome social de Anderson Herzer e foi apenas com o sobrenome que assinou esse volume no qual são reunidos seus escritos, logrando mais de vinte edições desde então. Sua escrita é marcada pela sensação de não-pertencimento e pelas ressonâncias ontológicas de diversos traumas (tanto individuais como sociais. Assim, para Herzer a palavra é uma forma tanto de representar a vertigem espacial dos espaços claustrofóbicos onde a sociedade civil deposita seus dissidentes como de romper o silêncio e o sequestro de voz que a tais subjetividades posicionadas à margem são impingidos. Palavras-chave: Literatura brasileira contemporânea; escrita autobiográfica; questões de gênero.

  5. Effect of polyhedral-oligomeric-sil-sesquioxanes on thermal and mechanical behavior of SC-15 epoxy

    Directory of Open Access Journals (Sweden)

    2008-07-01

    Full Text Available In this study, thermal and mechanical properties of nanocomposites containing SC-15 epoxy resin and polyhedral-oligomeric-sil-sesquioxanes (POSS have been studied. Dynamic Mechanical Analysis (DMA results show that the addition of 5 wt% of POSS yielded a 13% increase in the storage modulus and a 16°C enhancement in Tg. Thermo gravimetric Analysis (TGA results show that the thermal stability of epoxy increased with higher POSS content. Tension tests were used to evaluate the mechanical properties of materials. Both modulus and tensile strength are linear functions of POSS content. Scanning Electric Microscopy (SEM pictures of fracture surfaces show that the roughness of the fracture surfaces of epoxy increased after adding POSS. Based on experiment results, a three-parameter nonlinear constitutive equation was developed to describe the strain-softening stress-strain relationship behavior of materials. The parameters in this model are the elastic modulus, a strain exponent, m, and a compliance factor, β. Their relationships to the POSS weight fraction were obtained from the experiment results. The simulated stress-strain curves from the model agree with the test data. Analysis of the model shows that both the strain exponent, m, which controls the strain softening and hardening effect of the material, and the compliance parameter, β, which controls the flow stress level of the material, increase with higher POSS content.

  6. O silêncio no cotidiano do adolescente com HIV/AIDS

    Directory of Open Access Journals (Sweden)

    Maria da Graça Corso da Motta

    2013-06-01

    Full Text Available Este estudo caracteriza-se por ser uma pesquisa qualitativa que objetivou desvelar a percepção e a vivência em relação ao tratamento antirretroviral do adolescente com síndrome da imunodeficiência adquirida. A pesquisa foi realizada em serviços de referência em dois municípios na região sul do Brasil. A produção dos dados foi desenvolvida com a dinâmica de criatividade e sensibilidade mapa falante, por cinco participantes. Foi aplicada a técnica de análise temática do conteúdo. Das produções artísticas e depoimentos emergiram o cotidiano do uso dos medicamentos e o silêncio do diagnóstico da doença e do tratamento que implicam o cuidado à saúde. Conclui-se que é necessário o envolvimento dos profissionais de saúde, possibilitando espaços para a família e promovendo diálogos desta com o adolescente, visando à adesão ao tratamento.

  7. Automated genomic DNA purification options in agricultural applications using MagneSil paramagnetic particles

    Science.gov (United States)

    Bitner, Rex M.; Koller, Susan C.

    2002-06-01

    The automated high throughput purification of genomic DNA form plant materials can be performed using MagneSil paramagnetic particles on the Beckman-Coulter FX, BioMek 2000, and the Tecan Genesis robot. Similar automated methods are available for DNA purifications from animal blood. These methods eliminate organic extractions, lengthy incubations and cumbersome filter plates. The DNA is suitable for applications such as PCR and RAPD analysis. Methods are described for processing traditionally difficult samples such as those containing large amounts of polyphenolics or oils, while still maintaining a high level of DNA purity. The robotic protocols have ben optimized for agricultural applications such as marker assisted breeding, seed-quality testing, and SNP discovery and scoring. In addition to high yield purification of DNA from plant samples or animal blood, the use of Promega's DNA-IQ purification system is also described. This method allows for the purification of a narrow range of DNA regardless of the amount of additional DNA that is present in the initial sample. This simultaneous Isolation and Quantification of DNA allows the DNA to be used directly in applications such as PCR, SNP analysis, and RAPD, without the need for separate quantitation of the DNA.

  8. Uncharismatic Invasives

    Directory of Open Access Journals (Sweden)

    Clark, Jonathan L.

    2015-05-01

    Full Text Available Although philosophers have examined the ethics of invasive species management, there has been little research approaching this topic from a descriptive, ethnographic perspective. In this article I examine how invasive species managers think about the moral status of the animals they seek to manage. I do so through a case study of Oregon’s efforts to manage the invasive species that are rafting across the Pacific attached to tsunami debris in the wake of the Japanese tsunami of 2011. Focusing on the state’s response to a dock that washed ashore on Agate Beach with various marine invertebrates attached to it, I argue that these animals’ position on two intersecting scales of moral worth—the sociozoologic scale and the phylogenetic scale—rendered them unworthy of moral consideration.

  9. EL LOCUS DE DISTRIBUCION COMO COROLARIO DEL LOCUS DE CONTROL

    Directory of Open Access Journals (Sweden)

    Luisa Mayoral

    2009-01-01

    Full Text Available Este es un artículo científico acerca del Locus de Distribución, surgido de un estudio realizado con una población de docentes y alumnos universitarios. Respecto de los primeros, se ha indagado acerca de las atribuciones que se realizaban en torno a las recompensas y sanciones, que ellos distribuían a sus alumnos. Respecto de los segundos, se ha buscado determinar la valoración que estos realizaban de sus profesores, en términos de aquellas atribuciones. Para ello, se utilizaron dos paradigmas clásicamente empleados para verificar la existencia de una norma: el paradigma de la autopresentación (docentes, y el paradigma de los juicios (alumnos. La cuestión planteada fue determinar si en el caso de los comportamientos distributivos de refuerzos, las causas se atribuían a variables externas -en particular a los receptores de esos refuerzos- y si esas formas de atribución eran conocidas y valoradas o no, por los alumnos. De los resultados, surgió la confirmación de nuestra hipótesis de explicaciones externas en materia de comportamientos distributivos de sanciones en el ámbito de la docencia y la valoración positiva de estas atribuciones por los alumnos.

  10. Translocations affecting human immunoglobulin heavy chain locus

    Directory of Open Access Journals (Sweden)

    Sklyar I. V.

    2014-03-01

    Full Text Available Translocations involving human immunoglobulin heavy chain (IGH locus are implicated in different leukaemias and lymphomas, including multiple myeloma, mantle cell lymphoma, Burkitt’s lymphoma and diffuse large B cell lymphoma. We have analysed published data and identified eleven breakpoint cluster regions (bcr related to these cancers within the IgH locus. These ~1 kbp bcrs are specific for one or several types of blood cancer. Our findings could help devise PCR-based assays to detect cancer-related translocations, to identify the mechanisms of translocations and to help in the research of potential translocation partners of the immunoglobulin locus at different stages of B-cell differentiation.

  11. Duas formas de se ouvir o silêncio: revisitando 4'33"

    Directory of Open Access Journals (Sweden)

    Fábio Akcelrud Durão

    2005-12-01

    Full Text Available Após tecer rápidas considerações sobre arte e nada, o presente texto reinterpreta o 4'33'', de John Cage, no atual contexto de superprodução semiótica. Salienta-se que, ao invés de ser uma abertura para a vida, a peça depende tanto de uma justificativa teórica, quanto de uma disposição formal. Vem desta uma dupla possibilidade, pois o silêncio de 4'33'' pode ser tanto concebido como o objetivo (impossível a ser alcançado, quanto um meio para se interromper o falatório das coisas. Correspondendo a estas duas possibilidades estão diferentes estruturas de dissociação de meios e fins: a busca concentrada e uma passividade agressiva. Estas duas posturas são relacionadas no texto ao estado atual do capitalismo, caracterizado por uma superprodução mercantil de signos.After briefly dwelling on the relationship between art and nothing(ness, the essay interprets John Cage's so-called silent piece, his much-commented 4'33'', in the context of today's semiotic overproduction. It posits a twofold way of listening to the piece, insofar as silence may be conceived either as the (impossible aim to be reached by listening, or as a means to interrupt the continuous blabbering of things. Underlying these two possibilities there are different dispositions of means and ends, namely a concentrated search for something and an aggressive passivity. These two postures are related in the text to the current state of capitalism, characterized as it is by a commodified overproduction of signs.

  12. Generación controlada de nanocoloides de plata en materiales silíceos amorfos

    Directory of Open Access Journals (Sweden)

    Gil, C.

    2004-04-01

    Full Text Available Amorphous silica-based materials bulk and superficially doped with silver nanocolloids were prepared. Bulk doped glasses were obtained by conventional melting and doped monolithic slabs by sol-gel. Superficially doped glasses were obtained by ion-exchange and doped coatings by sol-gel. The samples were characterised by TEM and UV-VIS spectrophotometry. Depending on the composition, the silver incorporation process, and the thermal treatments, several colourings were obtained. By controlling these parameters, metallic silver nanocolloids can be generated in the matrices studied. Colloids aggregation and growing up depends on the matrix nature and on the experimental process carried out.

    Se prepararon materiales silíceos amorfos dopados con nanocoloides de plata en masa y en superficie. Se obtuvieron vidrios dopados en masa por fusión convencional y láminas monolíticas dopadas por sol-gel. Asimismo se prepararon vidrios dopados superficialmente por cambio iónico y recubrimientos dopados por sol-gel. Los materiales se caracterizaron por MET y espectrofotometría UV-VIS. Dependiendo de la composición del material, del proceso de incorporación de la plata y de los tratamientos térmicos, se obtuvieron diferentes coloraciones. El control de estas variables permitió generar nanocoloides metálicos de plata en las matrices estudiadas. La agregación y crecimiento de los coloides depende de la naturaleza de la matriz y del proceso experimental utilizado.

  13. Religiosidade no contexto médico: entre a receptividade e o silêncio

    Directory of Open Access Journals (Sweden)

    Anderson Nunes Pinto

    Full Text Available Pesquisa realizada em um programa de hemodiálise de um hospital público universitário do Rio de Janeiro investigou percepções de um grupo de médicos em relação à religiosidade de seus pacientes frente à doença e ao tratamento. Foi usada como base teórica a Teoria das Representações Sociais de Moscovici e a metodologia quali-quantitativa de análise do discurso do sujeito coletivo (DSC. Os discursos revelaram o reconhecimento da presença e da importância das crenças religiosas no contexto da assistência médica, sendo elas valorizadas como um recurso psicológico tanto no enfrentamento das dificuldades da doença e do tratamento, no caso dos pacientes, quanto no enfrentamento das situações difíceis vividas no exercício profissional, no caso dos médicos. Também evidenciaram a existência de dificuldades em conversar sobre o assunto com os pacientes e o silêncio sobre ele entre os colegas médicos. Os resultados encontrados indicam a necessidade de maior elaboração reflexiva sobre o assunto no grupo investigado, carência de maior investimento educacional na formação médica no que se refere às questões religiosas e maior divulgação, entre os médicos, de trabalhos publicados sobre o assunto.

  14. Confirmation of 5p12 As a Susceptibility Locus for Progesterone-Receptor-Positive, Lower Grade Breast Cancer

    DEFF Research Database (Denmark)

    Milne, Roger L; Goode, Ellen L; García-Closas, Montserrat

    2011-01-01

    Consortium. METHODS: Data were combined from 37 studies, including 40,972 invasive cases, 1,398 cases of ductal carcinoma in situ (DCIS), and 46,334 controls, all of white European ancestry, as well as 3,007 invasive cases and 2,337 controls of Asian ancestry. Associations overall and by tumor invasiveness......; P(trend) = 5 × 10(-7)]. CONCLUSION: 5p12 is a breast cancer susceptibility locus for PR-positive, lower grade breast cancer. Impact: Multicenter fine-mapping studies of this region are needed as a first step to identifying the causal variant or variants. Cancer Epidemiol Biomarkers Prev; 20...

  15. A New Era of Minimally Invasive Surgery: Progress and Development of Major Technical Innovations in General Surgery Over the Last Decade.

    Science.gov (United States)

    Siddaiah-Subramanya, Manjunath; Tiang, Kor Woi; Nyandowe, Masimba

    2017-10-01

    Minimally invasive surgery (MIS) continues to play an important role in general surgery as an alternative to traditional open surgery as well as traditional laparoscopic techniques. Since the 1980s, technological advancement and innovation have seen surgical techniques in MIS rapidly grow as it is viewed as more desirable. MIS, which includes natural orifice transluminal endoscopic surgery (NOTES) and single-incision laparoscopic surgery (SILS), is less invasive and has better cosmetic results. The technological growth and adoption of NOTES and SILS by clinicians in the last decade has however not been uniform. We look at the differences in new developments and advancement in the different techniques in the last 10 years. We also aim to explain these differences as well as the implications in general surgery for the future.

  16. Culture, gender and locus of control

    DEFF Research Database (Denmark)

    Ottsen, Christina Lundsgaard; Johannessen, Kim Berg; Berntsen, Dorthe

    The current study is a cross-cultural comparison between the Middle East and Scandinavia. Two societies that offer a unique opportunity to examine gender differences in personal goals and how goals are affected by locus of control.......The current study is a cross-cultural comparison between the Middle East and Scandinavia. Two societies that offer a unique opportunity to examine gender differences in personal goals and how goals are affected by locus of control....

  17. Relationships between locus of control and anxiety.

    Science.gov (United States)

    Archer, R P

    1979-12-01

    Reviews findings on the relationships between locus of control and anxiety and examines these relationships for three types of anxiety measures; general trait anxiety, situation specific trait anxiety, and state anxiety. In general, findings support the existence of meaningful relationships between greater externality and higher levels of both general trait anxiety and test anxiety. It was suggested that the relation between locus of control and state anxiety is a function of the situational context in which state anxiety is measured.

  18. A Recombinant DNA Plasmid Encoding the sIL-4R-NAP Fusion Protein Suppress Airway Inflammation in an OVA-Induced Mouse Model of Asthma.

    Science.gov (United States)

    Liu, Xin; Fu, Guo; Ji, Zhenyu; Huang, Xiabing; Ding, Cong; Jiang, Hui; Wang, Xiaolong; Du, Mingxuan; Wang, Ting; Kang, Qiaozhen

    2016-08-01

    Asthma is a chronic inflammatory airway disease. It was prevalently perceived that Th2 cells played the crucial role in asthma pathogenesis, which has been identified as the important target for anti-asthma therapy. The soluble IL-4 receptor (sIL-4R), which is the decoy receptor for Th2 cytokine IL-4, has been reported to be effective in treating asthma in phase I/II clinical trail. To develop more efficacious anti-asthma agent, we attempt to test whether the Helicobacter pylori neutrophil-activating protein (HP-NAP), a novel TLR2 agonist, would enhance the efficacy of sIL-4R in anti-asthma therapy. In our work, we constructed a pcDNA3.1-sIL-4R-NAP plasmid, named PSN, encoding fusion protein of murine sIL-4R and HP-NAP. PSN significantly inhibited airway inflammation, decreased the serum OVA-specific IgE levels and remodeled the Th1/Th2 balance. Notably, PSN is more effective on anti-asthma therapy comparing with plasmid only expressing sIL-4R.

  19. Clinical significance of measurements of changes of serum IL-2, SIL-2R and TNF-α levels after treatment in patients with rheumatoid arthritis

    International Nuclear Information System (INIS)

    Yu Songsan

    2007-01-01

    Objective: To study the changes of serum IL-2, SIL-2R and TNF-α levels after treatment in 39 patients with rheumatoid arthritis. Methods: Serum IL-2, TNF-α (with RIA) and SIL-2R (with ELISA) levels were measured in 39 patients with rheumatoid arthritis. Both before and one year after treatment as well as in 35 controls. Results: Before treatment in the patients the serum IL-2 levels were significantly lower and serum SIL-2R and TNF-α levels, were significantly higher than those in the controls (P<0.01), one year after treatment, the patients without recurrence (n=31) had their serum IL-2, SIL-2R and TNF-α levels returned to normal, but in patients with recurrences (n=8) the levels were about the same as those before treatment. Conclusion: Serum IL-2, SIL-2R and TNF-α lends were closely related to the diseases process and could be of prognostic value. (authors)

  20. Differential Aspects of Locus of Control and Attitudes Towards Death.

    Science.gov (United States)

    Hyams, Nanci Barbara; And Others

    1982-01-01

    Investigated the relationship between locus of control and death anxiety in 99 college students. Results indicated a significant relationship between external locus of control and concern about death, and a specific differential patterning between locus of control and death anxiety. Sex differences existed on four locus of control dimensions. (WAS)

  1. Systèmes d'innovation des pays BRICS (Brésil, Russie, Inde, Chine ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le Brésil, la Russie, l'Inde, la Chine et l'Afrique du Sud (dits pays BRICS) ont placé l'innovation au coeur de leur stratégie de développement. Toutefois, les chercheurs disposent de très peu de connaissances sur le système d'innovation de chacun de ces pays et sur les répercussions qu'il a sur l'économie. La subvention ...

  2. Silêncio e memória: cristianismo e dinastia constantiniana em Aurélio Vítor

    Directory of Open Access Journals (Sweden)

    Moisés Antiqueira

    2014-06-01

    Full Text Available O artigo almeja oferecer uma nova perspectiva acerca de um dos pontos mais intrigantes relativos à obra composta por Aurélio Vítor em fins do reinado de Constâncio II: o silêncio perante a religião cristã adotada pela dinastia reinante. Por meio de elementos articulados ao paganismo, propomos que Aurélio Vítor resgatou aspectos de uma memória social “pagã” que distinguiriam sua narrativa, revelando, pois, uma dimensão identitária.

  3. La réélection de Lula et la Gauche au Brésil

    Directory of Open Access Journals (Sweden)

    Adilar Cigolini

    2007-06-01

    Full Text Available Contrairement aux prévisions, Lula fut massivement réélu en 2006 avec l’appui des populations les plus défavorisées pour lesquelles il a mis en œuvre des mesures sociales notamment contre la faim, la discrimination ethnique ou la violence envers les femmes. Dans son premier mandat, il a promu l’action de l’Etat en instaurant la démocratie participative sur les thèmes de la santé, l’éducation, l’aménagement, l’environnement ou les droits de l’Homme, à laquelle les classes moyennes ont aussi adhéré. Grâce à sa personnalité charismatique et à son origine modeste, le peuple a le sentiment d’être représenté et s’identifie à lui. Economiquement parlant, il a néanmoins maintenu les grandes orientations du gouvernement précédent et par le biais de la négociation, il a renforcé le rôle régional (MERCOSUD et international du Brésil. Ceci montre qu’en Amérique Latine, les politiciens doivent désormais compter avec le peuple pour gouverner.Contrary to the forecasts, Lula was massively re-elected in 2006 with the support of the most underprivileged populations for which it implemented social measures in particular against the hunger, ethnic discrimination or violence towards the women. In its first mandate, it promoted the action of the State by founding the participative democracy on the topics of health, education, installation, the environment or the human rights, which the middle class also appreciated. Thanks to his charismatic personality and his modest origin, the people feel represented and is identified with him. Economically speaking, it nevertheless maintained the main trends of the preceding government and by the means of the negotiation, it reinforced the international and regional role (MERCOSUD of Brazil. This shows that in Latin America, the politicians must from now on take into account the people to govern.

  4. Resistência do algodoeiro à ferrugem tropical potencializada pelo silício

    Directory of Open Access Journals (Sweden)

    Antonia Mirian Nogueira de Moura Guerra

    2013-01-01

    Full Text Available Este trabalho teve como objetivo estudar o efeito do silício (Si sobre componentes de resistência do algodoeiro à ferrugem tropical causada por Phakopsora gossypii. Plantas das cultivares BRS Buriti e FM 993 cresceram em solução nutritiva contendo zero (-Si ou 2 mmol Si L- 1 (+Si. A maior concentração foliar de Si aumentou o período de incubação e o período latente em 9% e 14,3%, respectivamente, reduziu a área pustular, a área abaixo da curva de progresso da ferrugem e a área abaixo da curva de progresso da área da pústula em 27,5%, 36% e 22%, respectivamente. Nas plantas das cultivares BRS Buriti e FM 993 supridas com Si houve redução no número de pústulas em 70% e 30% e no número de urédias em 40,3% e 19,5%, respectivamente. A concentração de compostos fenólicos nas plantas da cultivar BRS Buriti supridas com Si aumentou até os 10 dai e, para a cultivar FM993, até os 30 dai. A concentração de derivados da lignina-ácido tioglicólico aumentou depois dos 20 dai para as duas cultivares supridas com Si. Atividade da peroxidas e aumentou até os 25 dai e os 10 dai para as plantas das cultivares BRS Buriti e FM 993 supridas com Si, respectivamente. A atividade da quitinase aumentou até 10 dai para as plantas da cultivar BRS Buriti e aos 10 e 20 dai para as plantas da cultivar supridas com Si. A atividade da glucanase aumentou até os 10 dai para as plantas da cultivar BRS Buriti supridas com Si e até os 20 dai para as plantas da cultivar FM 993 supridas com Si. Em conclusão, o suprimento de Si contribuiu para aumentar a resistência do algodoeiro à ferrugem devido à maior atividade das enzimas de defesa.

  5. Silêncio e literatura: as aporias da testemunha Silence and literature: the witness paradoxes

    Directory of Open Access Journals (Sweden)

    Anna Basevi

    2013-06-01

    Full Text Available Partindo do debate sobre os limites da linguagem diante da tragédia do extermínio nazista, pudemos constatar que a falta de respostas aos interrogativos sobre a Shoah é preenchida pelas tentativas da literatura de representar o evento gerando um discurso que inclua as lacunas, as impossibilidades, os paradoxos. As testemunhas deparam-se com dificuldades e aporias (entre as quais "o paradoxo de Levi" proposto por Agamben, vivenciam a "síndrome" do Velho Marinheiro, mas não são ouvidos ou atravessam as diversas décadas e fases históricas em silêncio até começar a contar sua experiência. Escritores como Primo Levi, Robert Antelme, Elie Wiesel, Jorge Semprún, Imre Kertész procuram o caminho da literatura onde o recurso da fabulação tenta superar as falhas da linguagem.Partendo dal dibattito sui limiti del linguaggio di fronte alla tragedia dello sterminio nazista, constatiamo che la mancanza di risposte agli interrogativi sulla Shoah è colmata dai tentativi della letteratura di rappresentare l´evento dando vita a un discorso che includa le lacune, le impossibilita, i paradossi. I testimoni si imbattono in difficoltà e aporie (tra cui "il paradosso di Levi" proposto da Agamben, sperimentano la "síndrome" del Vecchio Marinaio, ma non vengono ascoltati o attraversano vari decenni e fasi storiche in silenzio prima di iniziare a raccontare il proprio vissuto. Scrittori come Primo Levi, Robert Antelme, Elie Wiesel, Jorge Semprún, Imre Kertész tentano la via della letteratura in cui fare ricorso all´artificio narrativo può portare al superamento dei limiti del linguaggio.This study takes the move from the debate over the inability of language to express the tragedy of the Nazi extermination. We observe that the lack of answers to the questions raised by the Shoah is compensated by literary attempts to represent the events including omissions, impossibilities and paradoxes. Witnesses face difficulties and paradoxes (including Levi

  6. Soluble intercellular adhesion molecule-1 (sICAM-1) and soluble interleukin-2 receptors (sIL-2R) in scleroderma skin

    DEFF Research Database (Denmark)

    Søndergaard, Klaus; Deleuran, Mette; Heickendorff, Lene

    1998-01-01

    In order to investigate whether soluble intercellular adhesion molecule-1 (sICAM-1) and soluble interleukin-2 receptors (sIL-2R) were present in scleroderma skin, and to compare their levels to concentrations measured in plasma and clinical parameters, we examined suction blister fluid and plasma...... from 13 patients with systemic sclerosis and 11 healthy volunteers. Suction blisters and biopsies were from the transition zone between normal skin and scleroderma, and uninvolved abdominal skin. The levels of sICAM-1 and sIL-2R were significantly increased in both plasma and suction blister fluid from...... systemic sclerosis patients compared with healthy volunteers. ICAM-1 was localized to vessels and perivascular mononuclear infiltrates by immunohistochemical methods. IL-2R was expressed by CD3-positive cells. The elevated levels of sICAM-1 and sIL-2R in suction blister fluid point towards activation...

  7. Soluble interleukin 6 receptor (sIL-6R) mediates colonic tumor cell adherence to the vascular endothelium: a mechanism for metastatic initiation?

    LENUS (Irish Health Repository)

    Dowdall, J F

    2012-02-03

    The mechanisms by which surgery increases metastatic proliferation remain poorly characterized, although endotoxin and immunocytes play a role. Recent evidence suggests that endothelial adherence of tumor cells may be important in the formation of metastases. Soluble receptors of interleukin-6 (sIL-6R) shed by activated neutrophils exert IL-6 effects on endothelial cells, which are unresponsive under normal circumstances. This study examined the hypothesis that sIL-6R released by surgical stress increases tumor cell adherence to the endothelium. Neutrophils (PMN) were stimulated with lipopolysaccharide, C-reactive protein (CRP), and tumor necrosis factor-alpha. Soluble IL-6R release was measured by enzyme-linked immunosorbent assay. Colonic tumor cells transfected with green fluorescent protein and endothelial cells were exposed to sIL-6R, and tumor cell adherence and transmigration were measured by fluorescence microscopy. Basal release of sIL-6R from PMN was 44.7 +\\/- 8.2 pg\\/ml at 60 min. This was significantly increased by endotoxin and CRP (131 +\\/- 16.8 and 84.1 +\\/- 5.3, respectively; both P < 0.05). However, tumor necrosis factor-alpha did not significantly alter sIL-6R release. Endothelial and tumor cell exposure to sIL-6R increased tumor cell adherence by 71.3% within 2 h but did not significantly increase transmigration, even at 6 h. Mediators of surgical stress induce neutrophil release of a soluble receptor for IL-6 that enhances colon cancer cell endothelial adherence. Since adherence to the endothelium is now considered to be a key event in metastatic genesis, these findings have important implications for colon cancer treatment strategies.

  8. The use of TachoSil for the prevention of postoperative complications after groin dissection in cases of gynecologic malignancy.

    Science.gov (United States)

    Buda, Alessandro; Fruscio, Robert; Pirovano, Cecilia; Signorelli, Mauro; Betti, Marta; Milani, Rodolfo

    2012-06-01

    To evaluate the effect of TachoSil in preventing postoperative complications after groin dissection performed for primary or recurrent gynecologic malignancy. In a case-control analysis, the incidence of postoperative complications-including lymphocyst formation, wound breakdown and/or infection, and chronic lymphedema-was examined among 8 patients who received TachoSil and 16 controls (standard technique) treated for vulvar cancer or recurrent ovarian/breast cancer at San Gerardo Hospital, Monza, Italy, from 2008 to 2011. Thirty-eight inguinal dissections were performed in the 24 patients. Bilateral groin dissection was performed in 14 patients (n=4 in the study group; n=10 in the control group). Patients in the study group had a lower mean daily drainage volume than those in the control group (133 mL [range, 50-356 mL] vs 320 mL [range, 67-472 mL]; Pgynecologic malignancy. Copyright © 2012 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

  9. Les facteurs territoriaux de la compétitivité de la filière soja au Brésil

    Directory of Open Access Journals (Sweden)

    Bertrand Jean-Pierre

    2001-05-01

    Full Text Available Ce papier discute les facteurs de progression du complexe soja dans les régions de Cerrados du Nord du Brésil, proches de la forêt amazonienne. Le Mato Grosso est déjà le premier État producteur de soja du Brésil, tandis que le Para entre dans le processus de production intensif. Les deux États obtiennent des rendements élevés ; mais ils risquent de connaître des problèmes environnementaux du fait d’un usage excessif des pesticides.

  10. Origin of Long-Term Storage Stability and Nitric Oxide Release Behavior of CarboSil Polymer Doped with S-Nitroso-N-acetyl-D-penicillamine.

    Science.gov (United States)

    Wo, Yaqi; Li, Zi; Brisbois, Elizabeth J; Colletta, Alessandro; Wu, Jianfeng; Major, Terry C; Xi, Chuanwu; Bartlett, Robert H; Matzger, Adam J; Meyerhoff, Mark E

    2015-10-14

    The prolonged and localized delivery of nitric oxide (NO), a potent antithrombotic and antimicrobial agent, has many potential biomedical applications. In this work, the origin of the long-term storage stability and sustained NO release mechanism of S-nitroso-N-acetyl-D-penicillamine (SNAP)-doped CarboSil 20 80A polymer, a biomedical thermoplastic silicone-polycarbonate-urethane, is explored. Long-term (22 days) localized NO release is achieved by utilizing a cross-linked silicone rubber as topcoats, which can greatly reduce the amount of SNAP, NAP, and NAP disulfide leaching from the SNAP-doped CarboSil films, as measured by LC-MS. Raman spectroscopy and powder X-ray diffraction characterization of SNAP-doped CarboSil films demonstrate that a polymer-crystal composite is formed during the solvent evaporation process when SNAP exceeds its solubility in CarboSil (ca. 3.4-4.0 wt %). Further, when exceeding this solubility threshold, SNAP exists in an orthorhombic crystal form within the bulk of the polymer. The proposed mechanism of sustained NO release in SNAP-doped CarboSil is that the solubilized SNAP in the polymer matrix decomposes and releases NO, primarily in the water-rich regions near the polymer/solution interface, and the dissolved SNAP in the bulk polymeric phase becomes unsaturated, resulting in the dissolution of crystalline SNAP within the bulk of the polymer. This is a very slow process that ultimately leads to NO release at the physiological flux levels for >3 weeks. The increased stability of SNAP within CarboSil is attributed to the intermolecular hydrogen bonds between the SNAP molecules that crystallize. This crystallization also plays a key role in maintaining RSNO stability within the CarboSil polymer for >8 months at 37 °C (88.5% remains). Further, intravascular catheters fabricated with this new material are demonstrated to significantly decrease the formation of Staphylococcus aureus biofilm (a leading cause of nosocomial bloodstream

  11. Study on the changes of serum soluble IL-2 receptor (SIL-2R) levels and distribution pattern of peripheral blood T-cell subsets after treatment in pediatric patients with Bronchopneumonia

    International Nuclear Information System (INIS)

    Chen Chuanbin

    2005-01-01

    Objective:To investigate the significance of changes of serum SIL-2R levels and T-cell subsets distribution type after treatment in pediatric patients with bronchopneumonia. Methods: Serum SIL-2R levels (with ELISA) and peripheral blood T-cell subset distribution pattern (with monoclonal antibody technique) were determined in 33 pediatric patients with broncho-pneumonia and 30 controls. Results: Before treatment, the serum SIL-2R levels in the patients were significantly higher than those in normal controls (P 0.05). Serum SIL-2R levels were positively correlated with CD4/CD8 ratio. Conclusion: Detection of serum SIL-2R levels and CD4/CD8 ratio is clinically useful in the management of pediatric patients with bronchopneumonia. (authors)

  12. Geografia do trabalho no Brasil Géographie du travail au Brésil

    Directory of Open Access Journals (Sweden)

    Alexandre Gori Maia

    2009-06-01

    ídos do país. A área mais contígua de municípios mais desenvolvidos ocorre próxima aos dois principais estados brasileiros, São Paulo e Rio de Janeiro, além de importantes bolsões de desenvolvimento próximos à faixa litorânea. Os municípios rurais menos desenvolvidos, por sua vez, predominam nas áreas do semi-áridas do país, na floresta amazônica e na tríplice fronteira com os países do Mercosul.L'article traite de la configuration territoriale du travail au Brésil par l'analyse des structures d'activité et des rémunérations à l'échelle des municipes: la combinaison entre les catégories socio-professionnelles et les classes de salaire informe sur les niveaux de développement socio-économique des municipes et sur les inégalités du territoire brésilien. La profession est plus ou moins favorable en termes de revenus, mais elle a aussi des conséquences en termes de prestige social et de pouvoir politique. Compte tenu de l'extrême inégalité des salaires au Brésil, même dans des catégories professionnelles relativement homogènes, l'article prend le montant de salaire de l'activité principale comme second critère de classification. L'analyse statistique multivariée à partir des informations du recensement démographique de 2000 donne matière à une carte qui donne à voir une hiérarchie socio-économique des municipes brésiliens. La plupart des municipes pauvres  présentent des activités agricoles dominantes et  comptent beaucoup de travailleurs à bas salaire. Les municipes urbains les plus développés  concentrent une bonne partie de la population brésilienne et comptent à la fois beaucoup de personnes dans les strates de revenus élevées et beaucoup d'exclus. Les zones contiguës à ces municipes se trouvent à proximité des Etats de Sao Paulo et de Rio de Janeiro, ainsi que près du littoral. Les municipes ruraux les moins développés se trouvent, eux, dans la zone semi-aride, dans la forêt amazonienne et près de la

  13. Perbedaan Work-Family Conflict Ditinjau dari Locus of Control Internal dan Locus of Control Eksternal Pada Karyawan

    OpenAIRE

    Habibie, Wahyu

    2016-01-01

    Work-family conflict is a conflict between roles in work and family that are conflicting with each other. One cause of work-family conflict is the locus of control, which is one of personality characteristics. Locus of control possessed by each individual and can be divided into internal locus of control and external locus of control. The aim of this study is to see the difference of work-family conflict in terms of internal locus of control and external locus of control on employee. This ...

  14. Adnexal Masses Treated Using a Combination of the SILS Port and Noncurved Straight Laparoscopic Instruments: Turkish Experience and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Polat Dursun

    2013-01-01

    Full Text Available Objective. To report our experience treating adnexal masses using a combination of the SILS port and straight nonroticulating laparoscopic instruments. Study Design. This prospective feasibility study included 14 women with symptomatic and persistent adnexal masses. Removal of adnexal masses via single-incision laparoscopic surgery using a combination of the SILS port and straight nonroticulating laparoscopic instruments was performed. Results. All of the patients had symptomatic complex adnexal masses. Mean age of the patients was 38.4 years (range: 21–61 years and mean duration of surgery was 71 min (range: 45–130 min. All surgeries were performed using nonroticulating straight laparoscopic instruments. Mean tumor diameter was 6 cm (range: 5–12 cm. All patient pathology reports were benign. None of the patients converted to laparotomy. All the patients were discharged on postoperative d1. Postoperatively, all the patients were satisfied with their incision and cosmetic results. Conclusion. All 14 patients were successfully treated using standard, straight nonroticulating laparoscopic instruments via the SILS port. This procedure can reduce the cost of treatment, which may eventually lead to more widespread use of the SILS port approach. Furthermore, concomitant surgical procedures are possible using this approach. However, properly designed comparative studies with single port and classic laparoscopic surgery are urgently needed.

  15. Phylogenetic Analysis of the SNORD116 Locus

    Directory of Open Access Journals (Sweden)

    Matthew A. Kocher

    2017-11-01

    Full Text Available The SNORD116 small nucleolar RNA locus (SNORD116@ is contained within the long noncoding RNA host gene SNHG14 on human chromosome 15q11-q13. The SNORD116 locus is a cluster of 28 or more small nucleolar (sno RNAs; C/D box (SNORDs. Individual RNAs within the cluster are tandem, highly similar sequences, referred to as SNORD116-1, SNORD116-2, etc., with the entire set referred to as SNORD116@. There are also related SNORD116 loci on other chromosomes, and these additional loci are conserved among primates. Inherited chromosomal 15q11-q13 deletions, encompassing the SNORD116@ locus, are causative for the paternally-inherited/maternally-imprinted genetic condition, Prader–Willi syndrome (PWS. Using in silico tools, along with molecular-based and sequenced-based confirmation, phylogenetic analysis of the SNORD116@ locus was performed. The consensus sequence for the SNORD116@ snoRNAs from various species was determined both for all the SNORD116 snoRNAs, as well as those grouped using sequence and location according to a human grouping convention. The implications of these findings are put in perspective for studying SNORD116 in patients with inherited Prader–Willi syndrome, as well as model organisms.

  16. Locus of Control and Reading Attitude.

    Science.gov (United States)

    Brown, Dorotha H.; And Others

    1979-01-01

    The relationship between three measures of locus of control and eight dimensions of reading attitude were investigated for a sample of inner-city children. Finds that inner-city children who are willing to accept personal responsibility for negative events in their lives also tend to experience more anxiety about their reading. (Author)

  17. Protease inhibitor (Pi) locus, fertility and twinning

    NARCIS (Netherlands)

    Boomsma, D.I.; Frants, R.R.; Bank, R.A.; Martin, N.G.

    1992-01-01

    In a sample of 160 Dutch twin pairs and their parents, we found that mothers of dizygotic twins had frequencies of the S and Z alleles at the protease inhibitor (Pi) locus that were 3 times higher than a control sample. Mothers of identical twins also had a higher frequency of S than controls. The S

  18. Silício no processo infeccioso de Phakopsora pachyrhizi em folíolos de plantas de soja

    Directory of Open Access Journals (Sweden)

    Maria Fernanda Antunes da Cruz

    2012-01-01

    Full Text Available O objetivo deste trabalho foi avaliar o efeito do silício (Si no processo infeccioso de Phakopsora pachyrhizi em folíolos de soja cultivada em solução nutritiva com ou sem Si. Observações realizadas sob microscópio de luz e microscópio eletrônico de varredura indicaram que, nos folíolos das plantas supridas com Si, as urédias foram menores e em menor número. Houve redução de 27, 23 e 60% no número de lesões, urédias fechadas e urédias abertas, respectivamente, nos folíolos das plantas com Si. Plantas de soja supridas com Si apresentam redução nos sintomas da ferrugem-asiática-da-soja.

  19. Les transports aériens au Brésil, ou les ailes de la centralité

    OpenAIRE

    Théry , Hervé

    2004-01-01

    Les transports aériens trouvent au Brésil des conditions particulièrement favorables. L'exploitation d'un annuaire, régulièrement publié par la Direction de l'Aviation Civile brésilienne, permet de donner une idée des performances globales du secteur et des compagnies qui le constituent. Ses données sur les trafics donne les moyens de tracer des cartes de flux, qui dessinent de façon on ne peut plus claire les réseaux hiérarchisés qui reflètent bien la structure centralisée du pays, mais auss...

  20. Dessorção de fósforo por silício em solos cultivados com eucalipto

    Directory of Open Access Journals (Sweden)

    R. Carvalho

    2000-03-01

    Full Text Available Com o objetivo de avaliar a dessorção de fósforo por silício nas camadas superficiais de um Latossolo Vermelho-Escuro sob cerrado e de um Cambissolo sob campo cerrado, da zona fisiográfica Campos das Vertentes (MG, foram realizados experimentos em casa de vegetação do Departamento de Ciência do Solo da Universidade Federal de Lavras (MG, no período de agosto de 1997 a maio de 1998. Cada solo foi submetido a três incubações seqüenciais: (a CaCO3 + MgCO3, para manter o pH em torno de 6,0; (b fertilização básica, incluindo o fósforo em dose única, calculada para manter 0,2 mg L-1 de P em solução; (c seis doses de silício (CaSiO3, definidas com base na dose de fósforo. Plantas de eucalyptus grandis foram cultivadas por 120 dias em vasos com capacidade para 3 dm³ de solo. A produção de matéria seca e o teor de P na matéria seca foram avaliados aos 60, 90 e 120 dias do transplantio das mudas para os vasos. Ajustaram-se superfícies de resposta dessas variáveis às doses de Si e às épocas. O P dessorvido contribuiu com 15,25% do conteúdo do nutriente na matéria seca das plantas cultivadas no Cambissolo (maior teor de caulinita.

  1. Invasive amebiasis.

    Science.gov (United States)

    Grecu, F; Bulgariu, Teodora; Blanaru, Oana; Dragomir, C; Lunca, Claudia; Stratan, I; Manciuc, Carmen; Luca, V

    2006-01-01

    Digestive amoebiasis with his invasive form is an unusual pathology encountered in the temperate zone. This could lead to a life threatening complication: systemic amoebiasis. A 55-year-old male was treated successfully of systemic amoebiasis in a third referral hospital. The diagnosis was established based on epidemiology data and microscopical identification of trophozoites of Entamoeba histolytica. The amoebicidal, antibiotic and supportive treatments was firstly administrated. The clinical picture of intestinal amoebiasis raised from dysenteric syndrome to necrotizing enteritis. The bowel perforation with localized peritonitis was followed by chronic enteric fistula. Amoebic liver abscess, as the most frequent extraintestinal complication, was concomitantly diagnosed and treated. Urinary amoebiasis was considered as complication in the context of systemic dissemination: any other location could become a site of an amoebic abscess. Multidisciplinary approach was the successful key in the management of the patient, including antiparasitic therapy and antibiotic prophylaxis, intensive care and multiple surgical approaches. The diagnosis of digestive amoebiasis and systemic complication may be delayed in nonendemic areas, leading to advanced and complicated stages of the disease. The surgical approach is most efficiently to treat a large liver amoebic abscess and intraperitoneal collections.

  2. Surgical Value of Elective Minimally Invasive Gallbladder Removal: A Cost Analysis of Traditional 4-Port vs Single-Incision and Robotically Assisted Cholecystectomy.

    Science.gov (United States)

    Newman, Richard M; Umer, Affan; Bozzuto, Bethany J; Dilungo, Jennifer L; Ellner, Scott

    2016-03-01

    As the cost of health care is subjected to increasingly greater scrutiny, the assessment of new technologies must include the surgical value (SV) of the procedure. Surgical value is defined as outcome divided by cost. The cost and outcome of 50 consecutive traditional (4-port) laparoscopic cholecystectomies (TLC) were compared with 50 consecutive, nontraditional laparoscopic cholecystectomies (NTLC), between October 2012 and February 2014. The NTLC included SILS (n = 11), and robotically assisted single-incision cholecystectomies (ROBOSILS; n = 39). Our primary outcomes included minimally invasive gallbladder removal and same-day discharge. Thirty-day emergency department visits or readmissions were evaluated as a secondary outcome. The direct variable surgeon costs (DVSC) were distilled from our hospital cost accounting system and calculated on a per-case, per item basis. The average DVSC for TLC was $929 and was significantly lower than NTLC at $2,344 (p day discharge. There were no differences observed in secondary outcomes in 30-day emergency department visits (TLC [2%] vs NTLC [6%], p = 0.61) or readmissions (TLC [4%] vs NTLC [2%], p > 0.05), respectively. The relative SV was significantly higher for TLC (1) compared with NTLC (0.34) (p < 0.05), and SILS (0.66) and ROBOSILS (0.36) (p < 0.05). Nontraditional, minimally invasive gallbladder removal (SILS and ROBOSILS) offers significantly less surgical value for elective, outpatient gallbladder removal. Copyright © 2016 American College of Surgeons. Published by Elsevier Inc. All rights reserved.

  3. The Impact of Locus of Control on Language Achievement

    Science.gov (United States)

    Nodoushan, Mohammad Ali Salmani

    2012-01-01

    This study hypothesized that students' loci of control affected their language achievement. 198 (N = 198) EFL students took the Rotter's (1966) locus of control test and were classified as locus-internal (ni = 78), and locus-external (ne = 120). They then took their ordinary courses and at the end of the semester, they were given their exams.…

  4. Self-Esteem, Locus of Control, and Student Achievement.

    Science.gov (United States)

    Sterbin, Allan; Rakow, Ernest

    The direct effects of locus of control and self-esteem on standardized test scores were studied. The relationships among the standardized test scores and measures of locus of control and self-esteem for 12,260 students from the National Education Longitudinal Study 1994 database were examined, using the same definition of locus of control and…

  5. Bipolar disorder: Evidence for a major locus

    Energy Technology Data Exchange (ETDEWEB)

    Spence, M.A.; Flodman, P.L. [Univ. of California, Irvine, CA (United States); Sadovnick, A.D.; Ameli, H. [Univ. of British Columbia, Vancouver (Canada)] [and others

    1995-10-09

    Complex segregation analyses were conducted on families of bipolar I and bipolar II probands to delineate the mode of inheritance. The probands were ascertained from consecutive referrals to the Mood Disorder Service, University Hospital, University of British Columbia and diagnosed by DSM-III-R and Research Diagnostic Criteria. Data were available on over 1,500 first-degree relatives of the 186 Caucasian probands. The purpose of the analyses was to determine if, after correcting for age and birth cohort, there was evidence for a single major locus. Five models were fit to the data using the statistical package SAGE: (1) dominant, (2) recessive, (3) arbitrary mendelian inheritance, (4) environmental, and (5) no major effects. A single dominant, mendelian major locus was the best fitting of these models for the sample of bipolar I and II probands when only bipolar relatives were defined as affected (polygenic inheritance could not be tested). Adding recurrent major depression to the diagnosis {open_quotes}affected{close_quotes} for relatives reduced the evidence for a major locus effect. Our findings support the undertaking of linkage studies and are consistent with the analyses of the National Institutes of Mental Health (NIMH) Collaborative Study data by Rice et al. and Blangero and Elston. 39 refs., 4 tabs.

  6. Polymorphic microsatellite markers in the invasive shrub Buddleja davidii (Scrophulariaceae).

    Science.gov (United States)

    Schreiter, Susanne; Ebeling, Susan K; Durka, Walter

    2011-02-01

    Microsatellite primers were developed for the invasive plant Buddleja davidii, a Chinese shrub that is an invader in most other continents. An invasive population was analyzed using eight di- and tetranucleotide microsatellite loci. The number of alleles per locus ranged from 5 to 14. Due to polyploidy, exact genotypes could not be determined. Progeny arrays were used to study the outcrossing rate using presence/absence data of alleles resulting in an estimate of multilocus outcrossing rate of 93%. The markers were successfully tested in five congeneric species. The results indicate the utility of these loci in future studies of population genetics and breeding systems in B. davidii and in congeneric species.

  7. Soil reaction and absorption of silicon by rice Reação do solo e absorção de silício pelo arroz

    Directory of Open Access Journals (Sweden)

    Mônica Sartori de Camargo

    2007-01-01

    Full Text Available The solubility and availability of silicon can be influenced by soil reaction. A pot experiment with a clayey textured Rhodic Acrustox was conducted under greenhouse conditions to evaluate the effect of soil reaction on silicon availability to rice plants. The experiment was set up in a completely randomized design, using a factorial scheme (4 x 4 with four materials (calcitic lime, calcium and magnesium silicate, pure silicic acid, and wollastonite, four rates (0, 2500, 5000 and 7500 mg per 5 kg-pot and four replicates. After 60 days, dry matter yield and silicon absorption by the rice shoot plants, pH CaCl2, and soluble silicon (0.5 mol L-1 acetic acid and 0.01 mol L-1CaCl2 in the soil were evaluated. The materials increased soil pH as the applied rates increased, except silicic acid. Soluble silicon extracted by 0.5 mol L-1 acetic acid also increased with applied rates. For calcium chloride, soluble silicon increased in the soil only with wollastonite and calcium and magnesium silicate, agreeing with its total content. Silicon absorption by the above-ground part of the rice plants was linearly correlated with rates of wollastonite, followed by calcium and magnesium silicate, silicic acid and calcitic lime. Soil pH increase with lime was not sufficient to provide silicon to the rice. The 0.01 mol L-1 CaCl2 soluble silicon had the best correlation with silicon absorption by plants. More studies are necessary under field conditions and other soils to corroborate the presented results.A solubilidade e disponibilidade de silício podem ser influenciadas pela reação do solo. Com o objetivo de estudar o efeito da reação do solo sobre a disponibilidade de silício para a cultura do arroz, foi conduzido experimento em Latossolo Vermelho álico textura argilosa em casa-de-vegetação. O experimento foi conduzido em fatorial 4 x 4, delineamento em blocos inteiramente casualizados e quatro repetições. Quatro materiais (calcário, silicato de c

  8. Aspectos bioquímicos da resistência do algodoeiro à ramulose potencializada pelo silício

    Directory of Open Access Journals (Sweden)

    Antonia Mirian Nogueira de Moura Guerra

    2013-01-01

    Full Text Available Objetivou-se avaliar o efeito do silício (Si sobre a ramulose e aspectos bioquímicos da resistência do algodoeiro a essa doença. Os cultivares BRS Araçá e FM 993 foram desenvolvidos em solução nutritiva contendo (+Si ou não (-Si silício. Avaliou-se o período de incubação (PI, incidência (I, área abaixo da curva do índice da ramulose (AACIR e concentração foliar de Si (CFSi. A CFSi e o PI aumentaram em 76% e 19,5%, respectivamente, nas plantas +Si em relação às -Si, e a I e a AACIR diminuíram em 64% e 18%, respectivamente. A concentração dos compostos fenólicos solúveis totais (CFST e dos derivados da lignina-ácido tioglicólico (DLATG dos dois cultivares supridos com Si aumentou durante o progresso da ramulose, porém essa concentração foi inferior à daquelas que não receberam Si. No cultivar BRS Araçá +Si a atividade das enzimas quitinase (QUI e glicanase (GLI aumentou até os 10 dai em relação às plantas -Si. A atividade das enzimas peroxidase (POX e polifenoloxidase (PPO no cultivar BRS Araçá +Si aumentou entre 20 e 30 dai em relação às plantas -Si, enquanto na FM 993 +Si o aumento foi de até 10 dai. No cultivar FM 993 +Si, a atividade da fenilalanina amônia-liase (FAL aumentou. O fornecimento de Si às plantas de algodoeiro aumentou a resistência à ramulose mediante incremento na concentração CFST e de DLATG nos dois cultivares e na atividade das POX, PPO, QUI e GLI na BRS Araçá, e de POX e FAL na FM 993.

  9. Silício em plantas de feijão e arroz: absorção, transporte, redistribuição e tolerância ao cádmio

    OpenAIRE

    Lilian Aparecida de Oliveira

    2009-01-01

    A maioria das gramíneas possui absorção radicular de silício de forma ativa e são plantas acumuladoras de deste elemento. Já as leguminosas, possuem absorção passiva, são exclusoras de silício e não acumuladoras deste elemento. A maior parte do silício absorvido pelas raízes das plantas é depositada na forma de sílica amorfa combinada a compostos orgânicos como a celulose, podendo tornar o silício um elemento imóvel nas plantas, ou de baixa mobilidade. Os processos que regulam a absorção radi...

  10. Nitreto de silício depositado por sputtering reativo para aplicação em memória não-volátil

    OpenAIRE

    Matheus Coelho Adam

    2013-01-01

    No presente trabalho, foram desenvolvidos diferentes regimes de deposição de filmes de nitreto de silício, empregando a técnica de sputtering reativo, para a aplicação em memória não-volátil de aprisionamento de carga (charge trapping memory). Filmes finos de nitreto de silício com diferentes composições químicas e características físicas foram obtidos. As propriedades físicas dos mesmos foram analisadas utilizando-se medidas de elipsometria e caracterização elétrica por corrente-tensão. A co...

  11. sTREM-1, sIL-2Rα, and IL-6, but not sCD163, might predict sepsis in polytrauma patients: a prospective cohort study.

    Science.gov (United States)

    Trancă, S; Oever, J T; Ciuce, C; Netea, M; Slavcovici, A; Petrișor, C; Hagău, N

    2017-06-01

    To investigate whether sTREM-1, sIL-2Rα, sCD163, and IL-6 predict septic complications following polytrauma. Prospective observational study in a university hospital intensive care unit. Blood samples were drawn on admission, 24 and 48 h after the injury from 64 adult polytrauma patients. The occurence of infectious complications was investigated. The sepsis-free rates for the multiple trauma patients were considered as end points in the Kaplan-Meier plot analysis. Upon admission, sIL-2Rα mean values were higher in the T group compared to the T&S patients (1789 ± 1027 pg/mL versus 1280 ± 605 pg/mL, p = 0.02). The initial mean values of sTREM-1, IL-6, and sCD163 did not discriminate between the T and T&S groups patients (p > 0.05). sTREM-1 cutoff was 62 pg/mL: the sepsis-free rates differed significantly between the patients with sTREM-1 concentrations lower and higher than the cutoff (80 versus 48 %, p sepsis; for sIL-2Rα values in the range 946-1593 pg/mL, the sepsis-free rate was 68 %, while from the patients with sIL-2Rα sepsis-free (p = 0.05). sCD163 cutoff of 1000 ng/mL did not discriminate between the patients (76 versus 64 %, p = 0.28). For IL-6, the sepsis-free rates differed significantly between the patients with concentrations lower and higher than 400 pg/mL (78 versus 38 %, p sepsis in multiple trauma patients. Level II-Diagnostic tests and criteria.

  12. Clinical significance of the changes of serum levels of the rheumatoid activity markers IL-2, sIL-2R, HA and VEGF

    International Nuclear Information System (INIS)

    Bao Yong; Long Wubin; Yu Ke; Zeng Ying; Liu Deying

    2004-01-01

    Objective: To explore the relationship between rheumatoid activity and serum levels of the cytokines interleukin-2 (IL-2), soluble interleukin-2 receptor (sIL-2R), hyaluronic acid (HA), vascular endothelial growth factor (VEGF) in patients with rheumatoid arthritis. Methods: Serum IL-2, HA(with RIA) and sIL-2R, VEGF (with ELISA) levels were determined in 30 controls, 30 patients with active rheumatoid arthritis and 30 patients with rheumatoid arthritis in remission. Sensitivity and specificity for each marker were analyzed. Results: In patients with active rheumatoid arthritis, the serum levels of sIL-2R, HA, VEGF were significantly higher and serum levels of IL-2 significantly lower than those in patients in remission and controls (p<0.01). Determination of VEGF levels possessed the highest specificity (93.3%) and also a high sensitivity (93.3% as well). Conclusion: Determination of the serum levels of any of these markers was valuable for monitoring the activity of the rheumatoid process. It is more desirable to take measurements of VEGF levels due to its highest specificity

  13. Determination of traces of palladium in stream sediment and auto catalyst by FI-ICP-OES using on-line separation and preconcentration with QuadraSil TA.

    Science.gov (United States)

    Nakajima, Junichi; Ohno, Masashi; Chikama, Katsumi; Seki, Tatsuya; Oguma, Koichi

    2009-09-15

    A flow injection analysis (FIA) method using on-line separation and preconcentration with a novel metal scavenger beads, QuadraSil TA, has been developed for the ICP-OES determination of traces of palladium. QuadraSil TA contains diethylenetriamine as a functional group on spherical silica beads and shows the highest selectivity for Pd(II) at pH 1 (0.1 mol l(-1) hydrochloric acid) solution. An aliquot of the sample solution prepared as 0.1 mol l(-1) in hydrochloric acid was passed through the QuadraSil TA column. After washing the column with the carrier solution, the Pd(II) retained on the column was eluted with 0.05 mol l(-1) thiourea solution and the eluate was directly introduced into an ICP-OES. The proposed method was successfully applied to the determination of traces of palladium in JSd-2 stream sediment certified reference material [0.019+/-0.001 microg g(-1) (n=3); provisional value: 0.0212 microg g(-1)] and SRM 2556 used auto catalyst certified reference material [315+/-4 microg g(-1) (n=4); certified value: 326 microg g(-1)]. The detection limit (3 sigma) of 0.28 ng ml(-1) was obtained for 5 ml of sample solution. The sample through puts for 5 ml and 100 microl of the sample solutions were 10 and 15 h(-1), respectively.

  14. An unexpected role for the yeast nucleotide exchange factor Sil1 as a reductant acting on the molecular chaperone BiP

    Science.gov (United States)

    Siegenthaler, Kevin D; Pareja, Kristeen A; Wang, Jie; Sevier, Carolyn S

    2017-01-01

    Unfavorable redox conditions in the endoplasmic reticulum (ER) can decrease the capacity for protein secretion, altering vital cell functions. While systems to manage reductive stress are well-established, how cells cope with an overly oxidizing ER remains largely undefined. In previous work (Wang et al., 2014), we demonstrated that the chaperone BiP is a sensor of overly oxidizing ER conditions. We showed that modification of a conserved BiP cysteine during stress beneficially alters BiP chaperone activity to cope with suboptimal folding conditions. How this cysteine is reduced to reestablish 'normal' BiP activity post-oxidative stress has remained unknown. Here we demonstrate that BiP's nucleotide exchange factor – Sil1 – can reverse BiP cysteine oxidation. This previously unexpected reductant capacity for yeast Sil1 has potential implications for the human ataxia Marinesco-Sjögren syndrome, where it is interesting to speculate that a disruption in ER redox-signaling (due to genetic defects in SIL1) may influence disease pathology. DOI: http://dx.doi.org/10.7554/eLife.24141.001 PMID:28257000

  15. Locus of control and online learning

    Directory of Open Access Journals (Sweden)

    Suretha Esterhuysen

    2004-10-01

    Full Text Available The integration of online learning in university courses is considered to be both inevitable and necessary. Thus there is an increasing need to raise awareness among educators and course designers about the critical issues impacting on online learning. The aim of this study, therefore, was to assess the differences between two groups of first-year Business Sciences learners (online and conventional learners in terms of biographic and demographic characteristics and locus of control. The study population consisted of 586 first-year learners of whom 185 completed the Locus of Control Inventory (LCI. The results show that the two groups of learners do not differ statistically significantly from each other with respect to locus of control. The findings and their implications are also discussed. Opsomming Die integrasie van aanlyn-leer in universiteitskursusse word beskou as sowel onafwendbaar as noodsaaklik. Daar is dus ’n toenemende behoefte om bewustheid onder opvoedkundiges en kursusontwerpers te kweek oor die kritiese aspekte wat ’n impak op aanlyn-leer het (Morgan, 1996. Daarom was die doel van hierdie ondersoek om die verskille tussen twee groepe eerstejaarleerders in Bestuurs- en Ekonomiese Wetenskap (aanlyn en konvensionele leerders te bepaal ten opsigte van biografiese en demografiese eienskappe en lokus van beheer. Die populasie het bestaan uit 586 eerstejaarleerders waarvan 185 die Lokus van Beheer Vraelys voltooi het. Die resultate toon dat die twee groepe leerders nie statisties beduidend van mekaar verskil het met betrekking tot lokus van beheer nie. Die bevindinge en implikasies word ook bespreek.

  16. Root Locus Algorithms for Programmable Pocket Calculators

    Science.gov (United States)

    Wechsler, E. R.

    1983-01-01

    Two algorithms are described which allow the plotting of individual points on a root locus diagram with or without time delay. The development was performed during the design of a continuous phase shifter used in the Baseband Antenna Combiner for the Deep Space Network (DSN). The algorithms, which are expected to be useful in similar DSN efforts, are simple enough to be implemented on a programmable pocket calculator. The coordinates of the open-loop zeros and poles, the gain constant K, and the time delay T are the data inputs.

  17. Cut Locus Construction using Deformable Simplicial Complexes

    DEFF Research Database (Denmark)

    Misztal, Marek Krzysztof; Bærentzen, Jakob Andreas; Anton, François

    2011-01-01

    In this paper we present a method for appproximating cut loci for a given point p on Riemannian 2D manifolds, closely related to the notion of Voronoi diagrams. Our method finds the cut locus by advecting a front of points equally distant from p along the geodesics originating at p and finding...... the lines of self-intersections of the front in the parametric space. This becomes possible by using the deformable simplicial complexes (DSC, [1]) method for deformable interface tracking. DSC provide a simple collision detection mechanism, allows for interface topology control, and does not require...

  18. National invasive species program

    Science.gov (United States)

    Anna Rinick

    2007-01-01

    The structure and function of the National Invasive Species Council was presented below. The names and contact information for the USDA Invasive Species coordinators as of February 2006 were presented on the next page.

  19. Impact of locus of control on health message effectiveness.

    Science.gov (United States)

    Kong, Ying; Shen, Fuyuan

    2011-10-01

    This article examined how individuals' locus of control might moderate the effect of health message frames. An experiment was conducted whereby participants read either individual- or social-responsibility message frames after their locus of control was primed. Results indicated that messages presented in individual-responsibility frames were more persuasive when people were primed with internal locus of control, whereas social-responsibility framed appeals were more persuasive when people were primed with external locus of control. These results were found for individuals in both high and low cognitive load conditions. Theoretical and practical implications of the findings are discussed.

  20. Beyond the locus of spectrally pure colors

    Science.gov (United States)

    Fairchild, Mark D.

    2008-01-01

    The spectrum locus of a CIE chromaticity diagram defines the boundary within which all physically realizable color stimuli must fall. While that is a physical and mathematical reality that cannot be violated, it is possible to create colors that appear as if they were produced by physically impossible stimuli. This can be accomplished through careful control of the viewing conditions and states of adaptation. This paper highlights the importance of considering color appearance issues in the design of displays and specification of color gamuts and illustrates how the perceived color gamut can be manipulated significantly through the relationship between white-point and primary luminance levels without changing the chromaticity gamut of a display system. Using a color appearance model, such as CIECAM02, display color gamuts can be specified in perceptual terms such as lightness, chroma, brightness, and colorfulness rather than in strictly physical terms of the stimuli that create these perceptions. Examination of these perceptual gamuts, and their relationships to the viewing conditions, allows demonstration of the possibility of producing display gamuts that appear to reach beyond the locus of pure spectral colors when compared with typical display setups.

  1. Reflexões sobre a sexualidade velada no silêncio dos corpos The sexuality coverded by the bodies silence

    Directory of Open Access Journals (Sweden)

    Lúcia Beatriz Ressel

    2001-06-01

    Full Text Available As relações humanas são mediadas pela comunicação verbal e não-verbal. A comunicação não-verbal expressa nossos sentimentos e emoções, complementa, contradiz e substitui a comunicação verbal. Este artigo é uma reflexão que permeia a questão da comunicação não-verbal na abordagem específica da sexualidade, a qual se encontra velada no silêncio dos corpos e que expressa os sentimentos que resultam do processo interrelacional de cada vivência. Os dados foram coletados através de entrevistas individuais no período de janeiro a março de 1995, com mulheres de uma região rural do interior do Rio Grande do Sul. São apresentados, neste trabalho, sinais não-verbais da paralinguagem, cinésica (linguagem do corpo, tacêsica (linguagem do toque e roupas e artefatos que demonstram a cultura, os valores e os preconceitos culturais sobre o tema sexualidade.The humane relations are mediated by the verbal and non-verbal communication. The non-verbal communication expresses our feelings and emotions, it complements, contradicts and replaces the verbal communication. This study reflects upon the non-verbal communication as an especific approach to sexuality covered by the bodies silence and it expresses the feelings which are determinated by the interrelation process of each experience. The data were colected through individual enterviews realized from January to March by the year 1995, according to the women from a countryside area in Rio Grande do Sul. It is included in this study the non-verbal signs of the "paralanguage", body language, touch language, and also clothes and items demonstrating the culture, value and cultural precoceptions about Sexuality.

  2. Ambassadeur du Royaume-Uni de Portugal et Brésil à Washington, 1816-20

    Directory of Open Access Journals (Sweden)

    Francisco Iglésias

    1977-09-01

    Full Text Available BOURDON, Léon. José Corrêa da Serra. Ambassadeur du Royaume-Uni de Portugal et Brésil à Washington, 1816-20. Paris: Fundação Calouste Gulbenkian. Centro Cultural Português. 1975. (primeiro parágrafo do texto Afirmar que a série "A evolução da humanidade" tem dado, desde sua fundação, por Henri Berr, contribuição das mais expressivas para o estudo da História, é, um truísmo. As dezenas de títulos já publicados constituem-se em prova substantiva, eliminando a necessidade de qualquer adjetivação. A chamada História Judaica tem sido privilegiada na coleção. As obras de Lods e de Guignebert, notadamente Israel, das origens até meados do século VIII, do primeiro, já ultrapassaram os estreitos limites do mundo acadêmico, para adquirirem o status de leitura indispensável para qualquer interessado no tema. Rigorosamente, a obra de Feuerwerker, não pode ser colocada lado a lado com as acima referidas. Dificilmente poderíamos classificá-la como obra de síntese — pelo menos de grande síntese. Pelo contrário, é um trabalho de minuciosa elaboração, fruto de longa pesquisa documental e centrada num tema específico.

  3. Personality and Locus of Control among School Children

    Science.gov (United States)

    Pandya, Archana A.; Jogsan, Yogesh A.

    2013-01-01

    The main purpose of this investigation is to find out the sex differences in personality traits and locus of control among school children. A total 60 children (30 boys and 30 girls) were taken as a sample. The research tool for personality, children personality questionnaire was used, which was made by Cattell and Porter. Locus of control was…

  4. Locus of control and investment in risky assets

    NARCIS (Netherlands)

    Salamanca Acosta, N.; de Grip, A.; Fouarge, D.; Montizaan, R.M.

    2013-01-01

    Using representative household panel data, we show that the investment behavior of households is related to the economic locus of control of household heads. A household’s internal locus of control in economic issues is positively related to its decision to hold risky assets as well as its share of

  5. Metacognition: As a Predictor of One's Academic Locus of Control

    Science.gov (United States)

    Arslan, Serhat; Akin, Ahmet

    2014-01-01

    The purpose of this study is to examine the effect of metacognition on one's academic locus of control. The study's sample group consists of 451 university students enrolled in various programs at Sakarya University, Turkey. In this study, the Metacognitive Awareness Inventory and the Academic Locus of Control Scale were used. The correlations and…

  6. Locus of control and investment in risky assets

    NARCIS (Netherlands)

    Salamanca, N.; de Grip, A.; Fouarge, D.; Montizaan, R.M.

    2013-01-01

    Using representative household panel data, we show that the investment behavior of households is related to the economic locus of control of household heads. A household's internal locus of control in economic issues is positively related to its decision to hold risky assets as well as its share of

  7. Locus - ASTRA | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available switchLanguage; BLAST Search Image Search Home About Archive Update History Data ...URL: ftp://ftp.biosciencedbc.jp/archive/astra/LATEST/astra_locus.zip File size: 887 KB Simple search URL htt...icing type (ex. cassette) About This Database Database Description Download License Update History of This Database Site Policy | Contact Us Locus - ASTRA | LSDB Archive ...

  8. A new strategy for estimating two-locus recombination fractions ...

    Indian Academy of Sciences (India)

    Linkage analysis is now being widely used to map markers on each chromosome in the human genome, to map genetic diseases, and to identify genetic forms of common diseases. Two-locus linkage analysis and multi-locus analysis have been investigated comprehensively, and many computer programs have been ...

  9. Locus of Control and Death Anxiety: A Reexamination.

    Science.gov (United States)

    Sadowski, Cyril J.; And Others

    1979-01-01

    Examined the relationship between locus of control and death anxiety. The Reid-Ware Three Factor Locus of Control Scale and Templer Death Anxiety Scale were administered to college students aged 17 to 49. Death anxiety loaded significantly on the Fatalism dimension for males and on the Social System Control dimension for females. (Author/BWF)

  10. Is this Red Spot the Blue Spot (locus ceruleum)?

    Energy Technology Data Exchange (ETDEWEB)

    Choe, Won Sick; Lee, Yu Kyung; Lee, Min Kyung; Hwang, Kyung Hoon [Gachon University Gil Hospital, Incheon (Korea, Republic of)

    2010-06-15

    The authors report brain images of 18F-FDG-PET in a case of schizophrenia. The images showed strikingly increased bilateral uptake in the locus ceruleum. The locus ceruleum is called the blue spot and known to be a center of the norepinephrinergic system.

  11. Pharmacists as Entrepreneurs or Employees: The Role of Locus of ...

    African Journals Online (AJOL)

    Purpose: To investigate whether locus of control distinguished between pharmacists who chose to become entrepreneurs and those who took up employee roles in pharmaceutical establishments. Methods: The enlarged version of Rotter's I-E scale designed to measure an individual's locus of control was used to survey a ...

  12. Nucleotide variation at the methionine synthase locus in an ...

    African Journals Online (AJOL)

    Nucleotide variation at the methionine synthase (MetE) locus within and among populations of an endangered forest tree Fokienia hodginsii in Vietnam was investigated in the present study. A total of 12 populations were sampled across Vietnam. The length of the sequenced locus varied from 1567 to 1559 bp. A total of 42 ...

  13. Dental outpatients: health locus of control correlates.

    Science.gov (United States)

    Ludenia, K; Donham, G W

    1983-11-01

    Examined relationships between the Multidimensional Health Locus of Control (MHLC) Scales, Beck Depression Inventory, Trait subscales of the State-Trait Personality Inventory, and dental ratings of oral hygiene and presence of periodontal disease with dental outpatients (N = 101) at a Veterans Administration Medical Center Dental Clinic. Results indicated that this sample of outpatients scored comparably on MHLC Health Internality and Health Externality to a sample reported by Wallston and Wallston. Older dental patients, in the present sample, scored significantly higher on Powerful Others Externality in contrast to younger Ss, which suggests greater reliance on health professionals for dental health. Confirmatory evidence is presented on the negative correlations of depression, anger, and anxiety with Health Internality. Differential approaches to dental treatment are discussed.

  14. Locus of Control Orientation: Parents, Peers, and Place.

    Science.gov (United States)

    Ahlin, Eileen M; Lobo Antunes, Maria João

    2015-09-01

    An internal locus of control contributes to positive youth outcomes such as a general well-being and academic success, while also serving as a protective factor against exposure to community violence and reducing negative behaviors like violence. Despite these benefits, very little is known about antecedents of an internal locus of control orientation. Without an understanding of what factors contribute to the development of an internal locus of control, it is not clear how to best encourage its formation. This study uses data from the Project on Human Development in Chicago Neighborhoods to examine whether various mesosystem variables (family management strategies, peer interactions, neighborhood context, and individual-level characteristics) are associated with an internal locus of control orientation among 1,076 youth ages 9-19 living in 78 Chicago neighborhoods. Study participants were Hispanic (46 %), African American (34 %), and White (15 %), and 50 % were female. The findings suggest that, while most levels of the mesosystem influence locus of control orientation, family management strategies are more prominent determinants of an internal locus of control than peers, neighborhood context, or individual characteristics. Parental supervision over the time a youth spends at home and family socioeconomic status are consistent predictors of an internal locus of control, while harsh discipline is associated with an external locus of control. The discussion examines the import of various parenting techniques in shaping an internal locus of control and considers future avenues for research to further unpack how antecedents of locus of control can vary across youth.

  15. Health Locus of Control尺度開発の歴史(社会科学編)

    OpenAIRE

    吉田, 由美; Yumi, YOSHIDA; 千葉県立衛生短期大学(看護学); Chiba College of Health Science

    1994-01-01

    This article describes the origins history of Health Locus of Control scales. First, Rotter's social learing theory, which is the theoretical background of the Health Locus of Control construct, is outlined. The scale and research trends of Locus of Control concept, and those of Health Locus of Control concept which are based on Locus of Control, are then reviewed. Finally, Health Locus of Control is discussed with regard to the implications for health education.

  16. Zpráva z konference o domácím násilí "A co příjde poté? Když rozchodem partnerství domácí násilí nekončí

    Czech Academy of Sciences Publication Activity Database

    Vohlídalová, Marta

    2008-01-01

    Roč. 9, č. 1 (2008), s. 68-68 ISSN 1213-0028. [„A co přijde poté? Když rozchodem partnerství domácí násilí nekončí…“. Praha, 21.11.2008] Institutional research plan: CEZ:AV0Z70280505 Keywords : domestic violence Subject RIV: AO - Sociology, Demography http://www.genderonline.cz

  17. A la recherche de l'opérationnalité : le cas de l'agriculture familiale dans le Nordeste du Brésil

    OpenAIRE

    Caron, P.; Sabourin, E.; Sautier, D.; Gama da Silva, P.C.; Tonneau, J.P.

    1997-01-01

    Le projet d'appui au développement de l'agriculture familiale dans le Nordeste du Brésil a pour but de produire des références méthodologiques (analyse de situation et intervention) pour la recherche (identification de thèmes prioritaires), pour le développement (connaissances pour l'action) et pour la formation. Pour atteindre ces objectifs, l'équipe du projet est impliquée dans différentes opérations de développement conduites en partenariat avec des acteurs locaux, en assurant trois princi...

  18. Biblioteca escolar: espaço de silêncio e interdição | School library: a place of silence and prohibition

    Directory of Open Access Journals (Sweden)

    Gustavo Grandini Bastos

    2011-10-01

    Full Text Available Resumo Postulamos que a biblioteca, ao legitimar e instaurar o silêncio em seu espaço impede de proporcionar aos leitores um espaço de possibilidades de construção de sentidos, de fuga e de contestação da ordem em que vivemos. Marcamos que, ainda mais pelo fato de trabalhar muito com alunos é complexo imaginar os mesmos se relacionando bem em um espaço tão sisudo. Ocorre ainda que quem comanda a biblioteca crê no silêncio como a ausência de sentido, ato vazio de qualquer rastro, buscando garantir uma ausência de quebrar uma segurança aparente, censurando o aluno, impedindo-o de enunciar outros sentidos além dos apresentados pelo professor, na sala de aula. Procuramos nesse trabalho, à luz da teoria discursiva, questionar e expor que o silêncio está longe de ser oco de sentidos e significados. Palavras-chave discurso; biblioteca escolar; silêncio; sentido; leitores Abstract We postulated that the library, when legitimating and to establish the silence in your space impedes of providing to the readers a space of possibilities of construction of senses, of escape and of reply of the order in that lived. We marked that, still more for the fact of working a lot with students is complex to imagine the same ones linking well in such a discerning space. It happens although who commands the library has faith in the silence as the sense absence, empty act of any trace, looking for to guarantee an absence of breaking an apparent safety, censuring the student, impeding him/it of enunciating other senses besides introduced them by the teacher, in the class room. We sought in that work, to the light of the discursive theory, to question and to expose that the silence is far away from being hollow of senses and meanings. Keywords discourse; school library; silence; sense; readers

  19. Susceptibilidad de agregados silíceos a la degradación frente a la reacción álcali - sílice

    OpenAIRE

    Maiza, Pedro; Marfil, Silvina Andrea

    2003-01-01

    Los diferentes tipos de sílice, cuarzo, calcedonia, tridimita, cristobalita y ópalo tienden a degradarse en medio alcalino, por lo que provocan reacciones deletéreas cuando son utilizados como agregado para hormigón. Estos minerales corresponden a variedades de sílice micro, poli o criptocristalina y constituyen rocas tales como arenisca, porcelanita, jaspe, geiserita, ftanita, pedernal, chert y algunas de origen orgánico como son diatomila, radiolarila y madera fósil (xilópalo). En...

  20. Níquel, outros micronutrientes e silício e a ferrugem asiática (Phakopsora pachyrhizi) na cultura da soja (Glycine max)

    OpenAIRE

    Queiroz, Camila de Souza

    2012-01-01

    Uma alternativa de manejo da ferrugem-asiática (Phakopsora pachyrhizi) na soja é a nutrição adequada das plantas, uma vez que os nutrientes minerais são diretamente envolvidos em mecanismos de defesa, como componentes integrais das células, das membranas, das enzimas e dos transportadores de elétrons ou como ativadores, inibidores e reguladores do metabolismo. Neste contexto, objetivou-se através deste trabalho avaliar a influência de micronutrientes (B, Zn, Mn e Cu), silício e níquel na seve...

  1. Adhesions, inflammatory response and foreign body giant cells infiltration of the topical hemostats TachoSil®, Hemopatch™ and Veriset™

    DEFF Research Database (Denmark)

    Schiøtt Nissen, Line; Hunter, Jacob; Schrøder, Henrik Daa

    2017-01-01

    Background: When liver bleeding cannot be controlled by conventional methods, a topical hemostatic patch can be applied during surgery. In recent years new hemostats have become available. The aim of this study was to investigate the degree of adhesion and inflammation for three topical hemostatic...... patches, TachoSil®, Hemopatch™ and Veriset™. Methods: In 60 adult male Sprague Dawley rats liver two lesions were induced with a scalpel. Each rat was treated with two of the three patches tested. After 1, 2 and 3 months the animals were euthanized and macroscopic evaluation of adhesions and histological...

  2. Moderniser la démarche visant la qualité de l'eau au Brésil | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    20 sept. 2017 ... Après la rupture d'un grand barrage au sud-est du Brésil, des déchets métalliques et de boue contaminèrent l'eau et causèrent la pire catastrophe écologique de l'histoire de la nation. La recherche d'Adalto Bianchini aide son pays à réviser sa règlementation relative à une de ses ressources les plus ...

  3. Formação e reatividade de filmes finos de macrocíclicos de ferro sobre silício monocristalino

    OpenAIRE

    Juliana Salvador Andresa

    2007-01-01

    Neste trabalho foi estudado o desenvolvimento de uma superfície modelo de silício monocristalino, SiO2/Si, modificada com organossilanos derivados de N-heterocíclicos que permitisse a imobilização de um complexo de coordenação, FeTIM. Estas superfícies modificadas poderão ser empregadas em estudos de reatividade frente a analitos de interesse, como o NO. Sob esse aspecto, a síntese desses novos silanos, contendo N-heterocíclicos, e o desenvolvimento de uma metodologia de formação dos filmes f...

  4. [Prolonged exposure to crystalline silica Min-U-Sil-5 influences apoptosis or extracellular matrix genes expression in human bronchial epithelial cells].

    Science.gov (United States)

    Gambelunghe, A; Antognelli, C; Murgia, N; dell'Omo, M; Talesa, V N; Muzi, G

    2011-01-01

    Crystalline silica (Min-U-Sil-5) induces oxidative stress in human bronchial epithelial cells (BEAS-2B), through the intracellular accumulation of ROS that cause oxidative damage leading to the degradation of extracellular matrix (ECM) proteins and to the loss of cell adhesion molecules inducing apoptosis and genotoxic damage. This paper briefly summarizes some of the recent findings from our laboratories with emphasis on the molecular events by which the cronic and cumulative exposure to crystalline silica can induce cellular damage that promotes changes in extracellular matrix and in apoptosis gene expression.

  5. EL LOCUS DE DISTRIBUCION COMO COROLARIO DEL LOCUS DE CONTROL (THE LOCUS OF DISTRIBUTION AS A COROLLARY TO THE LOCUS OF CONTROL

    Directory of Open Access Journals (Sweden)

    Mayoral Luisa

    2009-08-01

    Full Text Available Resumen: Este es un artículo científico acerca del Locus de Distribución, surgido de un estudio realizado con una población de docentes y alumnos universitarios. Respecto de los primeros, se ha indagado acerca de las atribuciones que se realizaban en torno a las recompensas y sanciones, que ellos distribuían a sus alumnos.Respecto de los segundos, se ha buscado determinar la valoración que estos realizaban de sus profesores, en términos de aquellas atribuciones. Para ello, se utilizaron dos paradigmas clásicamente empleados para verificar la existencia de una norma: el paradigma de la autopresentación (docentes, y el paradigma de los j uicios (alumnos. La cuestión planteada fue determinar si en el caso de los comportamientos distributivos de refuerzos, las causas se atribuían a variables externas -en particular a los receptores de esos refuerzos- y si esas formas de atribución eran conocidas y valoradas o no, por los alumnos. De los resultados, surgió la confirmación de nuestra hipótesis de explicaciones externas en materia de comportamientos distributivos de sanciones en el ámbito de la docencia y la valoración positiva de estas atribuciones por los alumnos.Abstract:This one is a scientific article brings over of the Locus of Distribution, arisen from a study realized with a population of teachers and university pupils. Respect of the first ones, it has been investigated brings over of the attributions that were concerning around the reinforcements which they were distributing to pupils. Respect of the second ones, one has sought to determine the valuation that these realized of the teachers, in terms of those attributions. For it, two paradigms were in use classic used to check the existence of a norm: the paradigm of the auto-presentation (teachers, and the paradigm of the judgments (pupils The raised question was to determine if in case of the distributive behaviours of reinforcements, the reasons were assuming to external

  6. Diagnosing pre-invasive cervical lesions – experience with pap ...

    African Journals Online (AJOL)

    58.1%), vaginal discharge (20.3%), postcoital bleeding (12.0%) and postmenopausal bleeding 43 (7.6%). Of the total smears reported, epithelial abnormalities seen include low grade SIL 30 (5.3%) and high grade SIL 9 (1.6%) respectively.

  7. Lactobacillus buchneri genotyping on the basis of clustered regularly interspaced short palindromic repeat (CRISPR) locus diversity.

    Science.gov (United States)

    Briner, Alexandra E; Barrangou, Rodolphe

    2014-02-01

    Clustered regularly interspaced short palindromic repeats (CRISPR) in combination with associated sequences (cas) constitute the CRISPR-Cas immune system, which uptakes DNA from invasive genetic elements as novel "spacers" that provide a genetic record of immunization events. We investigated the potential of CRISPR-based genotyping of Lactobacillus buchneri, a species relevant for commercial silage, bioethanol, and vegetable fermentations. Upon investigating the occurrence and diversity of CRISPR-Cas systems in Lactobacillus buchneri genomes, we observed a ubiquitous occurrence of CRISPR arrays containing a 36-nucleotide (nt) type II-A CRISPR locus adjacent to four cas genes, including the universal cas1 and cas2 genes and the type II signature gene cas9. Comparative analysis of CRISPR spacer content in 26 L. buchneri pickle fermentation isolates associated with spoilage revealed 10 unique locus genotypes that contained between 9 and 29 variable spacers. We observed a set of conserved spacers at the ancestral end, reflecting a common origin, as well as leader-end polymorphisms, reflecting recent divergence. Some of these spacers showed perfect identity with phage sequences, and many spacers showed homology to Lactobacillus plasmid sequences. Following a comparative analysis of sequences immediately flanking protospacers that matched CRISPR spacers, we identified a novel putative protospacer-adjacent motif (PAM), 5'-AAAA-3'. Overall, these findings suggest that type II-A CRISPR-Cas systems are valuable for genotyping of L. buchneri.

  8. Ecology of forest insect invasions

    Science.gov (United States)

    E.G. Brockerhoff; A.M. Liebhold

    2017-01-01

    Forests in virtually all regions of the world are being affected by invasions of non-native insects. We conducted an in-depth review of the traits of successful invasive forest insects and the ecological processes involved in insect invasions across the universal invasion phases (transport and arrival, establishment, spread and impacts). Most forest insect invasions...

  9. Autism, fever, epigenetics and the locus coeruleus.

    Science.gov (United States)

    Mehler, Mark F; Purpura, Dominick P

    2009-03-01

    Some children with autism spectrum disorders (ASD) exhibit improved behaviors and enhanced communication during febrile episodes. We hypothesize that febrigenesis and the behavioral-state changes associated with fever in autism depend upon selective normalization of key components of a functionally impaired locus coeruleus-noradrenergic (LC-NA) system. We posit that autistic behaviors result from developmental dysregulation of LC-NA system specification and neural network deployment and modulation linked to the core behavioral features of autism. Fever transiently restores the modulatory functions of the LC-NA system and ameliorates autistic behaviors. Fever-induced reversibility of autism suggests preserved functional integrity of widespread neural networks subserving the LC-NA system and specifically the subsystems involved in mediating the cognitive and behavioral repertoires compromised in ASD. Alterations of complex gene-environmental interactions and associated epigenetic mechanisms during seminal developmental critical periods are viewed as instrumental in LC-NA dysregulation as emphasized by the timing and severity of prenatal maternal stressors on autism prevalence. Our hypothesis has implications for a rational approach to further interrogate the interdisciplinary etiology of ASD and for designing novel biological detection systems and therapeutic agents that target the LC-NA system's diverse network of pre- and postsynaptic receptors, intracellular signaling pathways and dynamic epigenetic remodeling processes involved in their regulation and functional plasticity.

  10. THE LOCUS COERULEUS AND CENTRAL CHEMOSENSITIVITY

    Science.gov (United States)

    Gargaglioni, Luciane H.; Hartzler, Lynn K.; Putnam, Robert W.

    2010-01-01

    The locus coeruleus (LC) lies in the dorsal pons and supplies noradrenergic (NA) input to many regions of the brain, including respiratory control areas. The LC may provide tonic input for basal respiratory drive and is involved in central chemosensitivity since focal acidosis of the region stimulates ventilation and ablation reduces CO2-induced increased ventilation. The output of LC is modulated by both serotonergic and glutamatergic inputs. A large percentage of LC neurons are intrinsically activated by hypercapnia. This percentage and the magnitude of their response are highest in young neonates and decrease dramatically after postnatal day P10. The cellular bases for intrinsic chemosensitivity of LC neurons are comprised of multiple factors, primary among them being reduced extracellular and intracellular pH, which inhibit inwardly rectifying and voltage-gated K+ channels, and activate L-type Ca2+ channels. Activation of KCa channels in LC neurons may limit their ultimate response to hypercapnia. Finally, the LC mediates central chemosensitivity and contains pH-sensitive neurons in amphibians, suggesting that the LC has a long-standing phylogenetic role in respiratory control. PMID:20435170

  11. Cryptic invasions: a review

    Czech Academy of Sciences Publication Activity Database

    Morais, Pedro Miguel; Reichard, Martin

    613-614, February (2018), s. 1438-1448 ISSN 0048-9697 R&D Projects: GA ČR GA13-05872S Institutional support: RVO:68081766 Keywords : Conspecific invader * Biological invasions * Bibliometric * Invasiveness Subject RIV: EG - Zoology OBOR OECD: Environmental science s (social aspects to be 5.7) Impact factor: 4.900, year: 2016

  12. Use of a Fibrinogen/Thrombin-Based Collagen Fleece (TachoComb, TachoSil) With a Stapled Closure to Prevent Pancreatic Fistula Formation Following Distal Pancreatectomy.

    Science.gov (United States)

    Mita, Kazuhito; Ito, Hideto; Murabayashi, Ryo; Asakawa, Hideki; Nabetani, Masashi; Kamasako, Akira; Koizumi, Kazuya; Hayashi, Takashi

    2015-12-01

    Postoperative pancreatic fistula formation remains a source of significant morbidity following distal pancreatectomy. The aim of this study was to evaluate the rate of clinically significant fistulas (International Study Group on Pancreatic Fistula grade B and grade C) after distal pancreatectomy using a fibrinogen/thrombin-based collagen fleece (TachoComb, TachoSil) with a stapled closure. Seventy-five patients underwent distal pancreatectomy at our institution between January 2005 and March 2014. A fibrinogen/thrombin-based collagen fleece was applied to the staple line of the pancreas before stapling. Twenty-six patients (34.7%) developed a pancreatic fistula, 8 patients (10.7%) developed a grade B fistula, and no patients developed a grade C fistula. The duration of the drain was significantly different in patients with or without a pancreatic fistula (8.0 ± 4.5 vs. 5.4 ± 1.3 days, P = .0003). Histological analysis showed that there was a tight covering with the fibrinogen/thrombin-based collagen fleece. The fibrinogen/thrombin-based collagen fleece (TachoComb, TachoSil) with a stapled closure has low rates of fistula formation and provides a safe alternative to the conventional stapled technique in distal pancreatectomy. © The Author(s) 2015.

  13. LA RÉCENTE DINAMIQUE GEOECONOMIQUE DE LA CHAINE DE PRODUCTION DE SOJA AU BRÉSIL ET DANS LE MONDE

    Directory of Open Access Journals (Sweden)

    Roberto César Cunha

    2015-07-01

    Full Text Available L’agro-industrie de soja consolidé, au Brésil, à partir des années 1980, se constitue comme une des principales chaînes productives de la structure agricole brésilienne, offrant des grains, son de blé e d’huiles pour l’approvisionnement du marché interne et externe. Dans la récolte 2013/2014, la production a atteint plus de 87 millions de tonnes cultivées en trente millions hectares, qui représentent juste 8,9% dans la domaine cultivées au Bresil. Les exportations de soja em grains couvrent 42 millions de tonnes dans l’année agricole 2012/2013, l’équivalent a U$ 22,8 milliards. Les segments de grains, huile e son de blé ont gagné U$ S 31 milliards, qui signifie 12,8 % de toutes les ventes externes du Brésil et 31 % des exportations de l’agro-industrie brésiliens. Ce texte a pour objectif d’identifier les facteurs responsables de la recente dinamique de cette chaîne productive dans le territoire bresilien et son insertion au marché mondial.

  14. Multidimensional profiles of health locus of control in Hispanic Americans.

    Science.gov (United States)

    Champagne, Brian R; Fox, Rina S; Mills, Sarah D; Sadler, Georgia Robins; Malcarne, Vanessa L

    2016-10-01

    Latent profile analysis identified health locus of control profiles among 436 Hispanic Americans who completed the Multidimensional Health Locus of Control scales. Results revealed four profiles: Internally Oriented-Weak, -Moderate, -Strong, and Externally Oriented. The profile groups were compared on sociocultural and demographic characteristics, health beliefs and behaviors, and physical and mental health outcomes. The Internally Oriented-Strong group had less cancer fatalism, religiosity, and equity health attributions, and more alcohol consumption than the other three groups; the Externally Oriented group had stronger equity health attributions and less alcohol consumption. Deriving multidimensional health locus of control profiles through latent profile analysis allows examination of the relationships of health locus of control subtypes to health variables. © The Author(s) 2015.

  15. A new strategy for estimating two-locus recombination fractions ...

    Indian Academy of Sciences (India)

    2011-08-19

    locus recombination fractions under some natural inequality restrictions. J. Genet. ... mation strategy, called restricted projection algorithm (RPA). The new ...... Differentiating equation (8) to obtain the equation. 2λj(βj − β∗.

  16. Relationship among Dimensions of Family Communication Patterns and Locus of

    Directory of Open Access Journals (Sweden)

    Mohammad Hassan Anvari

    2014-05-01

    Full Text Available Background: This study was done to examine the relationship of self-efficacy with dimensions of family communication patterns and locus of control. Materials and Methods: The population of this study was all Isfahan University students in the 2010-2011 academic years. Two hundred seventy nine students from various faculties of the university selected by cluster sampling method. In this descriptive study were used from the revised scale of dimensions of family communication patterns, locus of control questionnaire and general self-efficacy scale. Results: Results showed that the dialogue orientation, locus of control and conformity orientation have a significant correlation with self-efficacy (p<0.01. In addition dialogue orientation, locus of control and conformity orientation predicted 13%, 7%, 2% of selfefficacy, respectively. Conclusion: Dialogue orientation in family is the most important predictor of students' self-efficacy.

  17. A locus for isolated cataract on human Xp.

    Science.gov (United States)

    Francis, P J; Berry, V; Hardcastle, A J; Maher, E R; Moore, A T; Bhattacharya, S S

    2002-02-01

    To genetically map the gene causing isolated X linked cataract in a large European pedigree. Using the patient registers at Birmingham Women's Hospital, UK, we identified and examined 23 members of a four generation family with nuclear cataract. Four of six affected males also had complex congenital heart disease. Pedigree data were collated and leucocyte DNA extracted from venous blood. Linkage analysis by PCR based microsatellite marker genotyping was used to identify the disease locus and mutations within candidate genes screened by direct sequencing. The disease locus was genetically refined to chromosome Xp22, within a 3 cM linkage interval flanked by markers DXS9902 and DXS999 (Zmax=3.64 at theta=0 for marker DXS8036). This is the first report of a locus for isolated inherited cataract on the X chromosome. The disease interval lies within the Nance-Horan locus suggesting allelic heterogeneity. The apparent association with congenital cardiac anomalies suggests a possible new oculocardiac syndrome.

  18. Quantitative trait locus (QTL) mapping for 100-kernel weight of ...

    African Journals Online (AJOL)

    hope&shola

    2010-12-06

    Zea mays L.), related to yield. To realize its ... Key words: Maize (Zea mays L.), 100-kernel weight, quantitative trait locus (QTL), recombinant inbred line. (RIL), nitrogen ... cient approach to realize genetic basis of trait, some.

  19. LOCUS OF CONTROL AND JOB SATISFACTION: PSU EMPLOYEES

    Directory of Open Access Journals (Sweden)

    Lakshman Vijayashree

    2011-11-01

    Full Text Available Previous research studies have demonstrated that internal/external locus of control impacts jobsatisfaction. The present study thus aims to analyze type of locus of control and its relation with jobsatisfaction. The study will be of great help for organization to understand and know what type oflocus of control their employees has and how it has an impact on job satisfaction.The objectives of this study were: 1- To identify the type of Locus of Control (i.e. Internal orExternal present in Public Sector Units (PSU in Bangalore and 2- To analyze the impact of differenttype of Locus of Control on job satisfaction of PSU Employees. Further hypothesis was also set tocheck the relationship between locus of control and job satisfaction. In addition, the relationshipbetween different demographic factors was also examined. The tool used for this study was LocoInventory. The concept of locus of control by Levenson (1972 was used to develop Loco Inventory(Locus of Control in Organization Inventory. The survey used a questionnaire, which had thirty fivestatements which highlights the factors that determine the locus of control and job satisfaction levelof the employees. The Ratio, ANOVA, and Correlation analysis were used as statistical techniquesfor analysis.The results indicate that there is a positive correlation between internal locus of control and jobsatisfaction as well as between External (other locus of control and job satisfaction. And in case ofExternal (Chance locus of control and job satisfaction there exists partial positive correlation. As perthis study Job satisfaction level among the employees is also good as the mean is 17, which is closerto maximum scale value of 25. As per ANOVA table there is a significant variance betweeninternality and age as well as between externality (chance and age. There is no significantrelationship between internality and demographic factors like gender and education. There is nosignificant relationship between

  20. [Health locus of control of patients in disease management programmes].

    Science.gov (United States)

    Schnee, M; Grikscheit, F

    2013-06-01

    Health locus of control beliefs plays a major role in improving self-management skills of the chronically ill - a main goal in disease management programmes (DMP). This study aims at characterising participants in disease management regarding their health locus of control. Data are based on 4 cross-sectional postal surveys between spring and autumn of 2006 and 2007 within the Health Care Monitor of the Bertelsmann Foundation. Among the 6 285 respondents, 1 266 are chronically ill and not enrolled in a DMP and 327 are participating in a DMP. A high internal locus of control (HLC) occurs significantly less often in DMP patients than in normal chronically ill patients (and healthy people) controlling for age, gender and social class. With increasing age, a high internal locus of control is also significantly less likely. When comparing healthy people, the chronically ill and the DMP participants a social gradient of a high internal locus of control belief can be observed. The weaker internal and higher doctor-related external locus of control of DMP participants should be carefully observed by the physician when trying to strengthen the patients' self-management skills. Evaluators of DMP should take into account the different baselines of DMP patients and relevant control groups and incorporate these differences into the evaluation. © Georg Thieme Verlag KG Stuttgart · New York.

  1. Neurolinguistic programming training, trait anxiety, and locus of control.

    Science.gov (United States)

    Konefal, J; Duncan, R C; Reese, M A

    1992-06-01

    Training in the neurolinguistic programming techniques of shifting perceptual position, visual-kinesthetic dissociation, timelines, and change-history, all based on experiential cognitive processing of remembered events, leads to an increased awareness of behavioral contingencies and a more sensitive recognition of environmental cues which could serve to lower trait anxiety and increase the sense of internal control. This study reports on within-person and between-group changes in trait anxiety and locus of control as measured on the Spielberger State-Trait Anxiety Inventory and Wallston, Wallston, and DeVallis' Multiple Health Locus of Control immediately following a 21-day residential training in neurolinguistic programming. Significant with-in-person decreases in trait-anxiety scores and increases in internal locus of control scores were observed as predicted. Chance and powerful other locus of control scores were unchanged. Significant differences were noted on trait anxiety and locus of control scores between European and U.S. participants, although change scores were similar for the two groups. These findings are consistent with the hypothesis that this training may lower trait-anxiety scores and increase internal locus of control scores. A matched control group was not available, and follow-up was unfortunately not possible.

  2. Two-locus linkage analysis in multiple sclerosis (MS)

    Energy Technology Data Exchange (ETDEWEB)

    Tienari, P.J. (National Public Health Institute, Helsinki (Finland) Univ. of Helsinki (Finland)); Terwilliger, J.D.; Ott, J. (Columbia Univ., New York (United States)); Palo, J. (Univ. of Helsinki (Finland)); Peltonen, L. (National Public Health Institute, Helsinki (Finland))

    1994-01-15

    One of the major challenges in genetic linkage analyses is the study of complex diseases. The authors demonstrate here the use of two-locus linkage analysis in multiple sclerosis (MS), a multifactorial disease with a complex mode of inheritance. In a set of Finnish multiplex families, they have previously found evidence for linkage between MS susceptibility and two independent loci, the myelin basic protein gene (MBP) on chromosome 18 and the HLA complex on chromosome 6. This set of families provides a unique opportunity to perform linkage analysis conditional on two loci contributing to the disease. In the two-trait-locus/two-marker-locus analysis, the presence of another disease locus is parametrized and the analysis more appropriately treats information from the unaffected family member than single-disease-locus analysis. As exemplified here in MS, the two-locus analysis can be a powerful method for investigating susceptibility loci in complex traits, best suited for analysis of specific candidate genes, or for situations in which preliminary evidence for linkage already exists or is suggested. 41 refs., 6 tabs.

  3. Successful biological invasion despite a severe genetic load.

    Directory of Open Access Journals (Sweden)

    Amro Zayed

    2007-09-01

    Full Text Available Understanding the factors that influence the success of ecologically and economically damaging biological invasions is of prime importance. Recent studies have shown that invasive populations typically exhibit minimal, if any, reductions in genetic diversity, suggesting that large founding populations and/or multiple introductions are required for the success of biological invasions, consistent with predictions of the propagule pressure hypothesis. Through population genetic analysis of neutral microsatellite markers and a gene experiencing balancing selection, we demonstrate that the solitary bee Lasioglossum leucozonium experienced a single and severe bottleneck during its introduction from Europe. Paradoxically, the success of L. leucozonium in its introduced range occurred despite the severe genetic load caused by single-locus complementary sex-determination that still turns 30% of female-destined eggs into sterile diploid males, thereby substantially limiting the growth potential of the introduced population. Using stochastic modeling, we show that L. leucozonium invaded North America through the introduction of a very small number of propagules, most likely a singly-mated female. Our results suggest that chance events and ecological traits of invaders are more important than propagule pressure in determining invasion success, and that the vigilance required to prevent invasions may be considerably greater than has been previously considered.

  4. Psicologia e Arquitetura: em busca do locus interdisciplinar Psychology and Architecture: looking for the interdisciplinary locus

    Directory of Open Access Journals (Sweden)

    Gleice Azambuja Elali

    1997-12-01

    Full Text Available Partindo do reconhecimento da inevitável interdisciplinaridade no estudo da relação pessoa-ambiente, o artigo discute a Psicologia Ambiental enquanto locus privilegiado na interseção entre Psicologia e Arquitetura, com especial ênfase para a interrelação ambiente construído - comportamento humano. Definindo a escolha dos métodos de pesquisa como fator crucial a esta posição interdisciplinar, o texto aponta os principais métodos atualmente utilizados, facilidades de aplicação e vantagens/desvantagens dos mesmos, defendendo a propriedade do uso de multimétodos na realização de trabalhos na área.Acknowledging interdisciplinarity as an inevitable condition for the study of person-environment relationship, the article discusses Environmental Psychology as locus of intersection between Psychology and Architecture, converging upon the interrelationship human behavior - built environment. Considering that the choice of research methods is an essential element to such an approach, the text defines the main methods and techniques used in this area, their application and advantages/disadvantages, emphasizing a multi-method strategy.

  5. Past, Present, and Future of Minimally Invasive Abdominal Surgery.

    Science.gov (United States)

    Antoniou, Stavros A; Antoniou, George A; Antoniou, Athanasios I; Granderath, Frank-Alexander

    2015-01-01

    Laparoscopic surgery has generated a revolution in operative medicine during the past few decades. Although strongly criticized during its early years, minimization of surgical trauma and the benefits of minimization to the patient have been brought to our attention through the efforts and vision of a few pioneers in the recent history of medicine. The German gynecologist Kurt Semm (1927-2003) transformed the use of laparoscopy for diagnostic purposes into a modern therapeutic surgical concept, having performed the first laparoscopic appendectomy, inspiring Erich Mühe and many other surgeons around the world to perform a wide spectrum of procedures by minimally invasive means. Laparoscopic cholecystectomy soon became the gold standard, and various laparoscopic procedures are now preferred over open approaches, in the light of emerging evidence that demonstrates less operative stress, reduced pain, and shorter convalescence. Natural orifice transluminal endoscopic surgery (NOTES) and single-incision laparoscopic surgery (SILS) may be considered further steps toward minimization of surgical trauma, although these methods have not yet been standardized. Laparoscopic surgery with the use of a robotic platform constitutes a promising field of investigation. New technologies are to be considered under the prism of the history of surgery; they seem to be a step toward further minimization of surgical trauma, but not definite therapeutic modalities. Patient safety and medical ethics must be the cornerstone of future investigation and implementation of new techniques.

  6. Healthcare associated infection: good practices, knowledge and the locus of control in heatlhcare professionals.

    Science.gov (United States)

    Taffurelli, Chiara; Sollami, Alfonso; Camera, Carmen; Federa, Francesca; Grandi, Annise; Marino, Marcella; Marrosu, Tiziano; Sarli, Leopoldo

    2017-07-18

      The incidence of Healthcare Associated Infections (HAI) is an important indicator of the quality of care. The behaviors associated with the prevention of infections are not only supported by rational knowledge or motivation, but are mediated by social, emotional and often stereotyped behaviors. The awarness of the good practices related to HAI, may be a factor. Other studies, identify how the perception of the problem in healthcare professionals is often influenced by a tendency towards an external Locus of Control: the patient, the family, the other wards, other care settings. The aim of this study is to investigate the perception of healthcare professionals. In particular they have been measured their  awarness of the good practices, perceptions of the potential contamination level of some commonly used objects, knowledge about the management of invasive devices, Locus of Control.   A cross-sectional correlational design was utilized.  An ad hoc questionnaire was interviewed by 222 health professionals nurses and physicians in a northern hospital of Italy. The percentage of professionals who have attended training courses over the last 5 years was quite high, both for upgrades on HAI (78.7%) and Vascular Catheters (78.8%), while the percentage of professionals who updated on bladder catheterization (59.46%) was lower. The mean  score of good practice awareness towards HAI (5.06), is high. The perception of the potential level of contamination of some devices had a  mean ranging from 4.62 (for the drip) to 5.26 (for the door handle). The average value of the Locus of Control (43.54) indicates that participants demonstrated a value that is midway between External and Internal. The correlation test analysis revealed no significant relationships among professionals'age, knowledge about HAI, or infection related venus catheter. Also, results revealed that there were statistically significant positive relationships between professionals' Good Practices

  7. PENGARUH LOCUS OF CONTROL INTERNAL, LOCUS OF CONTROL EKSTERNAL, MANAJEMEN WAKTU, DAN KREATIVITAS MENGAJAR TERHADAP MOTIVASI BERPRESTASI

    Directory of Open Access Journals (Sweden)

    Dita Alfitami

    2017-10-01

    Full Text Available The aims of this research were to know the influence of the internal locus of control, external locus of control, time management, and teaching creativity to achievement motivation (case study in introduction to Office Administration subject in class XI AP SMK N 1 Kendal lesson school year 2016/2017.The population in this study were all the tenth graders of the Office Administration study program at SMK Negeri 1 Kendal with the total number of 71 students. While the sample taken used was saturated samples because the population were less than 100 respondents. Data collection method used in this research, which use questionnaire. The data analysis using multiple linear regression analysis method, classic assumption test analysis, percentage descriptive analysis, and hypothesis test analysis with the help of SPSS 21 programs. The finding shows the results of multiple linear regression analysis obtained equation Y = -20,466 + 0,431 X1 + 0,301 X2 + 0,357 X3 + 0,364 X4+ e. Test of significance of regression equation with F test, obtained count = 43,846 with significance0.000 and less than 0,05. The amount of influence simultaneously or together from locus of control, external locus of control, time management, and teaching creativity to achievement motivation was71%. While influence in partial or individually for internal locus of control was 23,52%, external locus of control 12,67%, time management 22,84%, and teaching creativity 22,46%.

  8. Invasion biology of thrips.

    Science.gov (United States)

    Morse, Joseph G; Hoddle, Mark S

    2006-01-01

    Thrips are among the stealthiest of insect invaders due to their small size and cryptic habits. Many invasive thrips are notorious for causing extensive crop damage, vectoring viral diseases, and permanently destabilizing IPM systems owing to irruptive outbreaks that require remediation with insecticides, leading to the development of insecticide resistance. Several challenges surface when attempting to manage incursive thrips species. Foremost among these is early recognition, followed by rapid and accurate identification of emergent pest species, elucidation of the region of origin, development of a management program, and the closing of conduits for global movement of thrips. In this review, we examine factors facilitating invasion by thrips, damage caused by these insects, pre- and post-invasion management tactics, and challenges looming on the horizon posed by invasive Thysanoptera, which continually challenge the development of sustainable management practices.

  9. Microsatellite Markers for the Invasive Species Bidens alba (Asteraceae

    Directory of Open Access Journals (Sweden)

    Yong-Bin Lu

    2014-05-01

    Full Text Available Premise of the study: Microsatellite markers were developed in the invasive species Bidens alba (Asteraceae to assess its population structure and to facilitate tracking its expansion in China. Methods and Results: Using 454 pyrosequencing, 20 microsatellite primer sets were developed for B. alba. The markers were tested on one population of B. alba (30 individuals and one population of the closely related B. pilosa (30 individuals in China. For B. alba, all of the markers were polymorphic, and the number of alleles per locus ranged from three to 32. The expected heterozygosity values were from 0.3787 to 0.9284, and the Shannon–Wiener index was from 0.6796 to 2.8401. Conclusions: These markers will be useful for investigating the genetic structure, genetic diversity, and invasion dynamics of B. alba and will also be useful in studies of B. pilosa.

  10. Review article: silicon carbide. Structure, properties and processing Artigo revisão: carbeto de silício, estrtutura, propriedades e processamento

    Directory of Open Access Journals (Sweden)

    V. A. Izhevskyi

    2000-03-01

    Full Text Available In view of considerable interest in the development of liquid phase sintered structural and high-temperature ceramics on the base of silicon carbide, a comprehensive review of the data on structure, properties and the known methods of processing of silicon carbide seems timely. The most striking feature of silicon carbide is its polytypism, i.e. formation of a great number of different structural modifications without any change in composition. Although this feature of silicon carbide was extensively studied, no systematic up to date analysis was done. However, polytypism and the tendency of the polytypes to undergo structural transformations at working temperatures may lead to uncontrollable modification of the materials properties, and therefore needs to be fully understood. Furthermore, the recently developed liquid phase sintering technique for silicon carbide densification is of an undoubtful interest and the overview of the results achieved until present time may provide some guidelines for the ceramists.Em vista do considerável interesse no desenvolvimento de cerâmicas estruturais e para aplicações em alta temperatura, é oportuna uma revisão quanto a estrutura, propriedades e métodos conhecidos de processamento de cerâmicas a base de carbeto de silício sinterizados via fase líquida. A característica mais interessante do carbeto de silício é o seu politipismo, isto é, a formação de um grande número modificações estruturais para uma mesma composição. Embora este fenômeno venha sendo extensivamente estudado, não se tem até o momento, uma análise sistemática do mesmo, o que seria de extrema importância, uma vez que o politipismo e a tendência à transformação estrutural destes politipos em temperaturas típicas de trabalho podem levar a incontroláveis modificações nas propriedades do material. Além disso, os recentes avanços obtidos na densificação do carbeto de silício através da técnica de sinteriza

  11. Les politiques d’appui à l’agriculture familiale au Brésil : quelques éléments de comparaison avec le Maroc

    Directory of Open Access Journals (Sweden)

    Philippe Bonnal

    2015-10-01

    Full Text Available Au Brésil comme au Maroc, le secteur agricole est marqué par des différences extrêmes en termes de taille d’exploitation, ainsi que de niveaux d’équipement, de capitalisation et de techniques. L’article présente la politique brésilienne d’appui à l’agriculture familiale, et quelques éléments de comparaison avec les choix faits au Maroc. Les politiques agricoles brésiliennes proposent depuis une vingtaine d’années un appui spécifique aux exploitations familiales, avec notamment la constitution d’un ministère spécifique. De nombreux dispositifs d’appui à l’agriculture familiale ont été mis en place, dont notamment des crédits à taux préférentiel et des programmes d’achat de denrées agricoles pour les institutions publiques (écoles, hôpitaux, etc.. Dans les zones rurales particulièrement fragiles, des dispositifs permettent une coordination entre l’ensemble des politiques publiques concernant ces zones. Enfin, la conception et la mise en oeuvre de ces politiques publiques se font avec une forte implication des syndicats agricoles. Les politiques publiques brésiliennes et marocaines reconnaissent la dualité du monde agricole, mais cette dualité est définie par zone au Maroc, tandis qu’elle est fondée sur des caractéristiques explicites des exploitations au Brésil. Dans les deux pays, le coeur des politiques publiques d’appui aux exploitations familiales porte sur l’aide à l’investissement. Au-delà de ce coeur commun, les politiques brésiliennes ont plus spécifiquement développé des approches au niveau des territoires locaux et associent plus fortement qu’au Maroc les organisations professionnelles agricoles représentant l’agriculture familiale dans la conception de l’action publique. La comparaison des politiques agricoles au Maroc et au Brésil sur quelques éléments permet de souligner la forte étendue des choix qu’il est possible de considérer, pour définir des

  12. Strong conservation of rhoptry-associated-protein-1 (RAP-1) locus organization and sequence among Babesia isolates infecting sheep from China (Babesia motasi-like phylogenetic group).

    Science.gov (United States)

    Niu, Qingli; Valentin, Charlotte; Bonsergent, Claire; Malandrin, Laurence

    2014-12-01

    Rhoptry-associated-protein 1 (RAP-1) is considered as a potential vaccine candidate due to its involvement in red blood cell invasion by parasites in the genus Babesia. We examined its value as a vaccine candidate by studying RAP-1 conservation in isolates of Babesia sp. BQ1 Ningxian, Babesia sp. Tianzhu and Babesia sp. Hebei, responsible for ovine babesiosis in different regions of China. The rap-1 locus in these isolates has very similar features to those described for Babesia sp. BQ1 Lintan, another Chinese isolate also in the B. motasi-like phylogenetic group, namely the presence of three types of rap-1 genes (rap-1a, rap-1b and rap-1c), multiple conserved rap-1b copies (5) interspaced with more or less variable rap-1a copies (6), and the 3' localization of one rap-1c. The isolates Babesia sp. Tianzhu, Babesia sp. BQ1 Lintan and Ningxian were almost identical (average nucleotide identity of 99.9%) over a putative locus of about 31 Kb, including the intergenic regions. Babesia sp. Hebei showed a similar locus organization but differed in the rap-1 locus sequence, for each gene and intergenic region, with an average nucleotide identity of 78%. Our results are in agreement with 18S rDNA phylogenetic studies performed on these isolates. However, in extremely closely related isolates the rap-1 locus seems more conserved (99.9%) than the 18S rDNA (98.7%), whereas in still closely related isolates the identities are much lower (78%) compared with the 18S rDNA (97.7%). The particularities of the rap-1 locus in terms of evolution, phylogeny, diagnosis and vaccine development are discussed. Copyright © 2014 The Authors. Published by Elsevier B.V. All rights reserved.

  13. The GimA locus of extraintestinal pathogenic E. coli: does reductive evolution correlate with habitat and pathotype?

    Directory of Open Access Journals (Sweden)

    Timo Homeier

    Full Text Available IbeA (invasion of brain endothelium, which is located on a genomic island termed GimA, is involved in the pathogenesis of several extraintestinal pathogenic E. coli (ExPEC pathotypes, including newborn meningitic E. coli (NMEC and avian pathogenic E. coli (APEC. To unravel the phylogeny of GimA and to investigate its island character, the putative insertion locus of GimA was determined via Long Range PCR and DNA-DNA hybridization in 410 E. coli isolates, including APEC, NMEC, uropathogenic (UPEC, septicemia-associated E. coli (SEPEC, and human and animal fecal isolates as well as in 72 strains of the E. coli reference (ECOR collection. In addition to a complete GimA (approximately 20.3 kb and a locus lacking GimA we found a third pattern containing a 342 bp remnant of GimA in this strain collection. The presence of GimA was almost exclusively detected in strains belonging to phylogenetic group B2. In addition, the complete GimA was significantly more frequent in APEC and NMEC strains while the GimA remnant showed a higher association with UPEC strains. A detailed analysis of the ibeA sequences revealed the phylogeny of this gene to be consistent with that obtained by Multi Locus Sequence Typing of the strains. Although common criteria for genomic islands are partially fulfilled, GimA rather seems to be an ancestral part of phylogenetic group B2, and it would therefore be more appropriate to term this genomic region GimA locus instead of genomic island. The existence of two other patterns reflects a genomic rearrangement in a reductive evolution-like manner.

  14. Development of ten microsatellite loci in the invasive giant African land snail, Achatina (=Lissachatina) fulica Bowdich, 1822

    Science.gov (United States)

    Morrison, Cheryl L.; Springmann, Marcus J.; Iwanowicz, Deborah D.; Wade, Christopher M.

    2015-01-01

    A suite of tetra-nucleotide microsatellite loci were developed for the invasive giant African land snail, Achatina (=Lissachatina) fulica Bowdich, 1822, from Ion Torrent next-generation sequencing data. Ten of the 96 primer sets tested amplified consistently in 30 snails from Miami, Florida, plus 12 individuals representative of their native East Africa, Indian and Pacific Ocean regions. The loci displayed moderate levels of allelic diversity (average 5.6 alleles/locus) and heterozygosity (average 42 %). Levels of genetic diversity were sufficient to produce unique multi-locus genotypes and detect phylogeographic structuring among regional samples. The invasive A. fulica can cause extensive damage to important food crops and natural resources, including native flora and fauna. The loci characterized here will be useful for determining the origins and tracking the spread of invasions, detecting fine-scale spatial structuring and estimating demographic parameters.

  15. Superdiffusion of Carbon by Vacancies Irradiated with Soft X-Rays in CZ Silicon / Superdifūzija Ar Vakancēm Iestarota Ar Mīkstajiem Rentgenstariem CZ Silīcijā

    Directory of Open Access Journals (Sweden)

    Janavičius A. J.

    2015-10-01

    Full Text Available Rezumējums: Rentgena staru fotoni, absorbēti Si atoma iekšējos slāņos, izstaro fotoelektronus un Ožē elektronus, ģenerējot vakances, starpmezglu silīcija atomus, vakanču un skābekļa kompleksus. Čohraļska silīcija kristāli, kas pārklāti ar oglekli 0.1 μm biezuma kārtā, tika apstaroti ar rentgena stariem, izmantojot krievu difraktometru DRON-3M. Oglekļa un skābekļa difūzija un koncentrāciju izmaiņa silīcijā tika izmērīta izmantojot infrasarkano staru FTIR spektroskopiju. Rentgena staru ģenerētās ļoti ātrās oglekļa difūzijas vai superdifūzijas koeficients istabas temperatūrā silīcijā ir simtiem tūkstošu reižu lielāks nekā termodifūzijas gadījumā.

  16. Retroperitoneal abscess after transanal minimally invasive surgery: case report and review of literature

    Directory of Open Access Journals (Sweden)

    Aaron Raney

    2017-10-01

    Full Text Available Abscesses are a rare complication of transanal minimally invasive surgery and transanal endoscopic micro surgery. Reported cases have been in the rectal and pre-sacral areas and have been managed with either antibiotics alone or in conjunction with laparotomy and diverting colostomy. We report a case of a large retroperitoneal abscess following a Transanal minimally invasive surgery full thickness rectal polyp excision. The patient was successfully managed conservatively with antibiotics and a percutaneous drain. Retroperitoneal infection should be included in a differential diagnosis following a Transanal minimally invasive surgery procedure as the presentation can be insidious and timely intervention is needed to prevent further morbidity. Resumo: Os abscessos são uma complicação rara da cirurgia de ressecção transanal minimamente invasiva (TAMIS e da micro cirurgia endoscópica transanal (TEMS. Os casos notificados foram nas áreas rectal e pré-sacral e foram administrados com antibióticos isoladamente ou em conjunto com laparotomia e desvio de colostomia. Relatamos um caso de grande abscesso retroperitoneal após uma excisão de pólipo retal de espessura total TAMIS. O paciente foi tratado com sucesso com a administração de antibióticos e drenagem percutânea. Para prevenir mais morbidade é necessária incluir a infecção retroperitoneal no diagnostico diferencial após um procedimento TAMIS onde a apresentação pode ser insidiosa e a intervenção atempada. Keywords: Colorectal surgery, Transanal minimally invasive surgery (TAMIS, Retroperitoneal abscess, Natural orifice transluminal endoscopic surgery (NOTES, Single-site laparoscopic surgery (SILS, Surgical oncology, Palavras-chave: Cirurgia colorretal, Cirurgia de ressecção transanal minimamente invasiva (TAMIS, Abscesso retroperitoneal, Cirurgia endoscópica transluminal de orifício natural (NOTES, Cirurgia laparoscópica de único local (SILS, Oncologia cirúrgica

  17. Inferring Demographic History Using Two-Locus Statistics.

    Science.gov (United States)

    Ragsdale, Aaron P; Gutenkunst, Ryan N

    2017-06-01

    Population demographic history may be learned from contemporary genetic variation data. Methods based on aggregating the statistics of many single loci into an allele frequency spectrum (AFS) have proven powerful, but such methods ignore potentially informative patterns of linkage disequilibrium (LD) between neighboring loci. To leverage such patterns, we developed a composite-likelihood framework for inferring demographic history from aggregated statistics of pairs of loci. Using this framework, we show that two-locus statistics are more sensitive to demographic history than single-locus statistics such as the AFS. In particular, two-locus statistics escape the notorious confounding of depth and duration of a bottleneck, and they provide a means to estimate effective population size based on the recombination rather than mutation rate. We applied our approach to a Zambian population of Drosophila melanogaster Notably, using both single- and two-locus statistics, we inferred a substantially lower ancestral effective population size than previous works and did not infer a bottleneck history. Together, our results demonstrate the broad potential for two-locus statistics to enable powerful population genetic inference. Copyright © 2017 by the Genetics Society of America.

  18. Mutation at the Human D1S80 Minisatellite Locus

    Directory of Open Access Journals (Sweden)

    Kuppareddi Balamurugan

    2012-01-01

    Full Text Available Little is known about the general biology of minisatellites. The purpose of this study is to examine repeat mutations from the D1S80 minisatellite locus by sequence analysis to elucidate the mutational process at this locus. This is a highly polymorphic minisatellite locus, located in the subtelomeric region of chromosome 1. We have analyzed 90,000 human germline transmission events and found seven (7 mutations at this locus. The D1S80 alleles of the parentage trio, the child, mother, and the alleged father were sequenced and the origin of the mutation was determined. Using American Association of Blood Banks (AABB guidelines, we found a male mutation rate of 1.04×10-4 and a female mutation rate of 5.18×10-5 with an overall mutation rate of approximately 7.77×10-5. Also, in this study, we found that the identified mutations are in close proximity to the center of the repeat array rather than at the ends of the repeat array. Several studies have examined the mutational mechanisms of the minisatellites according to infinite allele model (IAM and the one-step stepwise mutation model (SMM. In this study, we found that this locus fits into the one-step mutation model (SMM mechanism in six out of seven instances similar to STR loci.

  19. Isolation and characterization of polymorphic microsatellite loci from the invasive plant Solidago canadensis (Asteraceae).

    Science.gov (United States)

    Zhao, S-Y; Sun, S-G; Guo, Y-H; Chen, J-M; Wang, Q-F

    2012-02-17

    Solidago canadensis, a clonal herb originally from North America (common name: Canada goldenrod), is an invasive species in many countries. We developed microsatellite primers for this species. Eleven polymorphic loci were generated and primers were designed. Polymorphism of these 11 loci was assessed in 35 plants from two populations (Wuhan and Shanghai) in China. The number of alleles per locus ranged from 3 to 14. The observed and expected heterozygosities varied from 0.0732 to 0.7391 and from 0.1177 to 0.8687, respectively. These microsatellite markers will be useful tools for studies of population genetics in the native and invasive range of this species.

  20. Desaprendendo o silêncio : uma experiência de trabalho com grupos de homens autores de violência contra a mulher

    OpenAIRE

    Marcos Antonio Ferreira do Nascimento

    2001-01-01

    A presente dissertação problematiza as discussões sobre homens, masculinidades e violência contra a mulher, a partir de projetos de intervenção social os Grupos de Homens. Ao longo da história, homens e masculinidades ficaram invisíveis em relação a problemática de gênero e suas correlações com o campo da saúde. Essa invisibilidade produziu um silêncio acerca da condição masculina trazendo consequências para a construção de narrativas de homens e mulheres. A questão da violência intrafa...

  1. Carbeto de Silício como Material Base para Sensores MEMS de Uso Aeroespacial: Uma Visão Geral

    OpenAIRE

    Fraga,M.A.; Pessoa,R. S.; Massi,M.; Maciel,H. S.

    2014-01-01

    Este artigo discute o emprego do carbeto de silício (SiC), na forma de substrato e filme fino, em sensores MEMS (Micro-Electro-Mechanical Systems) para aplicações em ambientes sujeitos a condições extremas, especialmente no setor aeroespacial. As propriedades físicas e químicas do SiC que o tornam um material adequado para dispositivos eletrônicos e sensores são descritas. Os conceitos, evolução e aplicações da tecnologia MEMS são apresentados. Uma visão geral sobre o estágio atual de desenvo...

  2. Jacky BUFFET, Industrialisation et développement au Brésil 1500-2000, Paris, Éditions L'Harmattan, 2000, 364 p.

    OpenAIRE

    Benoit, Bruno

    2009-01-01

    Jacky Buffet, en élève de Paul Bairoch, est un passionné d'histoire économique au cœur de laquelle il situe la question du développement. Il ne pouvait, ses travaux l'amenant à travailler sur l'Amérique latine, qu'être attiré par le Brésil, magnifique champ d'études depuis l'arrivée des premiers colons en 1500. Ce livre écrit par un économiste du développement se veut résolument à dimension historique. Selon l'auteur, l'histoire est le vecteur explicatif, ce pour quoi je suis entièrement d'ac...

  3. Silício na micropropagação de orquídeas: características morfofisiológicas

    OpenAIRE

    Soares, Joyce Dória Rodrigues

    2013-01-01

    O cultivo in vitro de espécies de orquídeas constitui a base para a propagação massal de mudas livre de doenças. Este trabalho objetivou estudar o desenvolvimento fitotécnico, o comportamento fisiológico e ultraestrutural em orquídeas micropropagadas. Três experimentos foram realizados, os quais avaliaram: 1) concentrações de silício e qualidade de luz no cultivo in vitro; 2) anatomia de espécies híbrida e nativa sob concentrações de silicio; 3) estiolamento e luz artificial na multiplicação ...

  4. A lateral pós-vocálica no português de Londrina: análise variacionista e estrutura silábica

    Directory of Open Access Journals (Sweden)

    Hahn, Laura Helena

    2007-01-01

    Full Text Available O presente trabalho pretende analisar, a partir das perspectivas variacionista e fonológica, a realização variável da lateral pós-vocálica e está vinculado a um projeto maior intitulado "Realização variável da lateral pós-vocálica no português do sul do Brasil e seu condicionamento prosódico". No português brasileiro, a lateral em posição de final de sílaba é realizada de forma variável como /1/ alveolar, /1/ velar ou [w] (variante vocalizada. A literatura mostra que essa variação ocorre em função de condicionantes tanto sociais quanto lingüísticos. O curpus desse estudo foi coletado em entrevistas de 8 informantes (homens e mulheres, com mais ou menos de 50 anos e com escolaridade primária ou secundária da cidade de Londrina, Paraná. Entre as variáveis selecionadas pelo programa computacional VARBRUL 2000 estão contexto precedente e fronteira de morfema. Conforme os resultados estatísticos obtidos neste estudo, há uma predominância da vocalização. Uma das possíveis explicações para a variação em pauta seria a estrutura silábica do Português Brasileiro. Há propostas que afirmam que a lateral pós-vocálica estaria na coda da sílaba e há outras que dizem que a lateral está no núcleo silábico, devido à facilidade com que esta se torna vocalizada. O nosso objetivo é discutir essas propostas, verificando qual delas se mostra mais adequada

  5. Influência do contexto silábico da palavra no julgamento perceptivo-auditivo do ceceio produzido por pré-escolares

    Directory of Open Access Journals (Sweden)

    Viviane Cristina de Castro Marino

    2013-08-01

    Full Text Available OBJETIVOS: investigar a ocorrência do ceceio em fricativas produzidas por crianças com alterações oclusais e analisar a influência do contexto silábico da fricativa no julgamento auditivo do ceceio. M ÉTODO: estudo prospectivo, em que as gravações de 428 palavras, produzidas por 15 crianças (idade média de 5 anos e 1 mês foram julgadas auditivamente por três fonoaudiólogos com experiência no julgamento de alterações de fala. As palavras utilizadas foram constituídas pelas consoantes fricativas não vozeadas, alveolar e pós-alveolar, inseridas em posição tônica, precedida das vogais [i, a, u]. Obteve-se concordância intra-juiz (quase perfeita e inter-juiz (total, 100% previamente à análise dos aspectos de interesse. RESULTADOS: embora presente na fala de todas as crianças, identificou-se ceceio em 25,23% do total das palavras. Houve aumento significante do ceceio para: (a fricativa alveolar em ataque inicial, (b fricativa alveolar em ataque inicial em relação à coda medial (p=0,001 e (c fricativa alveolar em relação à fricativa pós- alveolar (p<0,001. Não se observou diminuição do ceceio em relação às vogais co-articuladas. CONCLUSÃO: a ocorrência do ceceio é dependente do contexto silábico, (com maior ocorrência na fricativa alveolar, em posição de ataque inicial, devendo o mesmo ser considerado para fins clínicos e de pesquisa sobre o ceceio.

  6. Lupus vulgaris occurring in a locus minoris resistentiae.

    Science.gov (United States)

    Long, Richard; Beatch, Anita; Lee, Mao-Cheng; Cheung-Lee, Melody; Wasel, Norman

    2009-01-01

    The pathogenesis of lupus vulgaris, a form of cutaneous tuberculosis, is not always clear, especially in patients who do not have coexistent extracutaneous tuberculosis and in patients with single lesions. To report a case of lupus vulgaris in a locus minoris resistentiae (a site of reduced resistance) and to use a unique set of clinical circumstances and laboratory tests to reconstruct the pathogenesis of the lesion and the response to treatment. Lupus vulgaris can occur in a locus minoris resistentiae; local trauma and possibly other factors, such as increased temperature, topical corticosteroids, and the virulence of the infecting strain, may facilitate the growth of Mycobacterium tuberculosis present at a locus minoris resistentiae as a result of a silent bacillemia.

  7. Locus-specific view of flax domestication history.

    Science.gov (United States)

    Fu, Yong-Bi; Diederichsen, Axel; Allaby, Robin G

    2012-01-01

    Crop domestication has been inferred genetically from neutral markers and increasingly from specific domestication-associated loci. However, some crops are utilized for multiple purposes that may or may not be reflected in a single domestication-associated locus. One such example is cultivated flax (Linum usitatissimum L.), the earliest oil and fiber crop, for which domestication history remains poorly understood. Oil composition of cultivated flax and pale flax (L. bienne Mill.) indicates that the sad2 locus is a candidate domestication locus associated with increased unsaturated fatty acid production in cultivated flax. A phylogenetic analysis of the sad2 locus in 43 pale and 70 cultivated flax accessions established a complex domestication history for flax that has not been observed previously. The analysis supports an early, independent domestication of a primitive flax lineage, in which the loss of seed dispersal through capsular indehiscence was not established, but increased oil content was likely occurred. A subsequent flax domestication process occurred that probably involved multiple domestications and includes lineages that contain oil, fiber, and winter varieties. In agreement with previous studies, oil rather than fiber varieties occupy basal phylogenetic positions. The data support multiple paths of flax domestication for oil-associated traits before selection of the other domestication-associated traits of seed dispersal loss and fiber production. The sad2 locus is less revealing about the origin of winter tolerance. In this case, a single domestication-associated locus is informative about the history of domesticated forms with the associated trait while partially informative on forms less associated with the trait.

  8. The chimpanzee GH locus: composition, organization, and evolution.

    Science.gov (United States)

    Pérez-Maya, Antonio A; Rodríguez-Sánchez, Irám P; de Jong, Pieter; Wallis, Michael; Barrera-Saldaña, Hugo A

    2012-06-01

    In most mammals the growth hormone (GH) locus comprises a single gene expressed primarily in the anterior pituitary gland. However, in higher primates multiple duplications of the GH gene gave rise to a complex locus containing several genes. In man this locus comprises five genes, including GH-N (expressed in pituitary) and four genes expressed in the placenta, but in other species the number and organization of these genes vary. The situation in chimpanzee has been unclear, with suggestions of up to seven GH-like genes. We have re-examined the GH locus in chimpanzee and have deduced the complete sequence. The locus includes five genes apparently organized in a fashion similar to that in human, with two of these genes encoding GH-like proteins, and three encoding chorionic somatomammotropins/placental lactogens (CSHs/PLs). There are notable differences between the human and chimpanzee loci with regard to the expressed proteins, gene regulation, and gene conversion events. In particular, one human gene (hCSH-L) has changed substantially since the chimpanzee/human split, potentially becoming a pseudogene, while the corresponding chimpanzee gene (CSH-A1) has been conserved, giving a product almost identical to the adjacent CSH-A2. Chimpanzee appears to produce two CSHs, with potentially differing biological properties, whereas human produces a single CSH. The pattern of gene conversion in human has been quite different from that in chimpanzee. The region around the GH-N gene in chimpanzee is remarkably polymorphic, unlike the corresponding region in human. The results shed new light on the complex evolution of the GH locus in higher primates.

  9. Emergent Minimally Invasive Esophagogastrectomy

    Directory of Open Access Journals (Sweden)

    Thomas Fabian

    2017-01-01

    Full Text Available Introduction. Esophageal perforation in the setting of a malignancy carries a high morbidity and mortality. We describe our management of such a patient using minimally invasive approach. Methods. An 83-year-old female presented with an iatrogenic esophageal perforation during the workup of dysphagia. She was referred for surgical evaluation immediately after the event which occurred in the endoscopy suite. Minimally invasive esophagectomy was chosen to provide definitive treatment for both her malignancy and esophageal perforation. Results. Following an uncomplicated operative course, she was eventually discharged to extended care for rehabilitation and remains alive four years after her resection. Conclusion. Although traditional open techniques are the accepted gold standard of treatment for esophageal perforation, minimally invasive esophagectomy plays an important role in experienced hands and may be offered to such patients.

  10. Correlacional study among locus of control and human values

    OpenAIRE

    Saulo Santos Menezes Almeida

    2008-01-01

    O presente estudo teve como objetivo central analisar as relações entre locus de controle e valores. Participaram 355 universitários de Sergipe, a maioria do sexo feminino (62,8%) e solteiros (80%), com média de idade de 25,68 anos (amplitude de 17 a 56 anos). Os estudantes responderam à escala de locus de controle de Reyes e a escala de valores de Schwartz. Os resultados indicaram ser os instrumentos aptos a mensurar o proposto pelo objetivo, apresentando índices psicométricos satisfatórios....

  11. Over-invasion by functionally equivalent invasive species.

    Science.gov (United States)

    Russell, James C; Sataruddin, Nurul S; Heard, Allison D

    2014-08-01

    Multiple invasive species have now established at most locations around the world, and the rate of new species invasions and records of new invasive species continue to grow. Multiple invasive species interact in complex and unpredictable ways, altering their invasion success and impacts on biodiversity. Incumbent invasive species can be replaced by functionally similar invading species through competitive processes; however the generalized circumstances leading to such competitive displacement have not been well investigated. The likelihood of competitive displacement is a function of the incumbent advantage of the resident invasive species and the propagule pressure of the colonizing invasive species. We modeled interactions between populations of two functionally similar invasive species and indicated the circumstances under which dominance can be through propagule pressure and incumbent advantage. Under certain circumstances, a normally subordinate species can be incumbent and reject a colonizing dominant species, or successfully colonize in competition with a dominant species during simultaneous invasion. Our theoretical results are supported by empirical studies of the invasion of islands by three invasive Rattus species. Competitive displacement is prominent in invasive rats and explains the replacement of R. exulans on islands subsequently invaded by European populations of R. rattus and R. norvegicus. These competition outcomes between invasive species can be found in a broad range of taxa and biomes, and are likely to become more common. Conservation management must consider that removing an incumbent invasive species may facilitate invasion by another invasive species. Under very restricted circumstances of dominant competitive ability but lesser impact, competitive displacement may provide a novel method of biological control.

  12. Heterotic trait locus (HTL) mapping identifies intra-locus interactions that underlie reproductive hybrid vigor in Sorghum bicolor.

    Science.gov (United States)

    Ben-Israel, Imri; Kilian, Benjamin; Nida, Habte; Fridman, Eyal

    2012-01-01

    Identifying intra-locus interactions underlying heterotic variation among whole-genome hybrids is a key to understanding mechanisms of heterosis and exploiting it for crop and livestock improvement. In this study, we present the development and first use of the heterotic trait locus (HTL) mapping approach to associate specific intra-locus interactions with an overdominant heterotic mode of inheritance in a diallel population using Sorghum bicolor as the model. This method combines the advantages of ample genetic diversity and the possibility of studying non-additive inheritance. Furthermore, this design enables dissecting the latter to identify specific intra-locus interactions. We identified three HTLs (3.5% of loci tested) with synergistic intra-locus effects on overdominant grain yield heterosis in 2 years of field trials. These loci account for 19.0% of the heterotic variation, including a significant interaction found between two of them. Moreover, analysis of one of these loci (hDPW4.1) in a consecutive F2 population confirmed a significant 21% increase in grain yield of heterozygous vs. homozygous plants in this locus. Notably, two of the three HTLs for grain yield are in synteny with previously reported overdominant quantitative trait loci for grain yield in maize. A mechanism for the reproductive heterosis found in this study is suggested, in which grain yield increase is achieved by releasing the compensatory tradeoffs between biomass and reproductive output, and between seed number and weight. These results highlight the power of analyzing a diverse set of inbreds and their hybrids for unraveling hitherto unknown allelic interactions mediating heterosis.

  13. Heterotic trait locus (HTL mapping identifies intra-locus interactions that underlie reproductive hybrid vigor in Sorghum bicolor.

    Directory of Open Access Journals (Sweden)

    Imri Ben-Israel

    Full Text Available Identifying intra-locus interactions underlying heterotic variation among whole-genome hybrids is a key to understanding mechanisms of heterosis and exploiting it for crop and livestock improvement. In this study, we present the development and first use of the heterotic trait locus (HTL mapping approach to associate specific intra-locus interactions with an overdominant heterotic mode of inheritance in a diallel population using Sorghum bicolor as the model. This method combines the advantages of ample genetic diversity and the possibility of studying non-additive inheritance. Furthermore, this design enables dissecting the latter to identify specific intra-locus interactions. We identified three HTLs (3.5% of loci tested with synergistic intra-locus effects on overdominant grain yield heterosis in 2 years of field trials. These loci account for 19.0% of the heterotic variation, including a significant interaction found between two of them. Moreover, analysis of one of these loci (hDPW4.1 in a consecutive F2 population confirmed a significant 21% increase in grain yield of heterozygous vs. homozygous plants in this locus. Notably, two of the three HTLs for grain yield are in synteny with previously reported overdominant quantitative trait loci for grain yield in maize. A mechanism for the reproductive heterosis found in this study is suggested, in which grain yield increase is achieved by releasing the compensatory tradeoffs between biomass and reproductive output, and between seed number and weight. These results highlight the power of analyzing a diverse set of inbreds and their hybrids for unraveling hitherto unknown allelic interactions mediating heterosis.

  14. Silicon leaf application and physiological quality of white oat and wheat seedsAplicação foliar de silício e qualidade fisiológica de sementes de aveia-branca e trigo

    Directory of Open Access Journals (Sweden)

    Mariane Sayuri Ishizuka

    2012-10-01

    Full Text Available Plant nutrition can positively influence quality of seeds by improving plant tolerance to adverse climate. In this context, silicon is currently considered a micronutrient and it is beneficial to plant growth, especially Poaceaes such as white oat and wheat, thereby improving physiological quality of seeds. This study had the objective of evaluating the effects of silicon leaf application on plant tillering, silicon levels and physiological quality of white oat and wheat seeds besides establishing correlations between them. Two experiments were carried out in winter with white oat and wheat. The experimental design was the completely randomized block with eight replications. Treatments consisted of foliar application of silicon (0.8% of soluble silicon, as stabilized orthosilicic acid and a control (with no application. Silicon levels in leaves were determined at flowering whereas the number of plants and panicles/spikes per area was counted right before harvest. Seed quality was evaluated right after harvest through mass, germination and vigor tests. Data was submitted to variance analysis and means were compared by the Tukey test at a probability level of 5%. Person’s linear correlation test was performed among silicon level in plants, tillering and seed quality data. Silicon leaf application increases root and total length of white oat seedlings as an effect of higher Si level in leaves. Silicon leaf application increases mass of wheat seeds without affecting germination or vigor. A nutrição das plantas pode influenciar positivamente a qualidade das sementes por proporcionar maior tolerância às adversidades climáticas. Neste contexto, o silício é atualmente considerado um micronutriente e tem efeito benéfico no crescimento das plantas, especialmente Poaceaes como aveia-branca e trigo, consequentemente melhorando a qualidade fisiológica das sementes. Este estudo objetivou avaliar os efeitos da aplicação foliar de silício no

  15. Exotic invasive plants

    Science.gov (United States)

    Carolyn Hull Sieg; Barbara G. Phillips; Laura P. Moser

    2003-01-01

    Ecosystems worldwide are threatened by nonnative plant invasions that can cause undesirable, irreversible changes. They can displace native plants and animals, out-cross with native flora, alter nutrient cycling and other ecosystem functions, and even change an ecosystem's flammability (Walker and Smith 1997). After habitat loss, the spread of exotic species is...

  16. Mechanisms Regulating Glioma Invasion

    Science.gov (United States)

    Paw, Ivy; Carpenter, Richard C.; Watabe, Kounosuke; Debinski, Waldemar; Lo, Hui-Wen

    2015-01-01

    Glioblastoma (GBM) is the most aggressive, deadliest, and most common brain malignancy in adults. Despite the advances made in surgical techniques, radiotherapy and chemotherapy, the median survival for GBM patients has remained at a mere 14 months. GBM poses several unique challenges to currently available treatments for the disease. For example, GBM cells have the propensity to aggressively infiltrate/invade into the normal brain tissues and along the vascular tracks, which prevents complete resection of all malignant cells and limits the effect of localized radiotherapy while sparing normal tissue. Although anti-angiogenic treatment exerts anti-edematic effect in GBM, unfortunately, tumors progress with acquired increased invasiveness. Therefore, it is an important task to gain a deeper understanding of the intrinsic and post-treatment invasive phenotypes of GBM in hopes that the gained knowledge would lead to novel GBM treatments that are more effective and less toxic. This review will give an overview of some of the signaling pathways that have been shown to positively and negatively regulate GBM invasion, including, the PI3K/Akt, Wnt, sonic hedgehog-GLI1, and microRNAs. The review will also discuss several approaches to cancer therapies potentially altering GBM invasiveness. PMID:25796440

  17. Minimally invasive distal pancreatectomy

    NARCIS (Netherlands)

    Røsok, Bård I.; de Rooij, Thijs; van Hilst, Jony; Diener, Markus K.; Allen, Peter J.; Vollmer, Charles M.; Kooby, David A.; Shrikhande, Shailesh V.; Asbun, Horacio J.; Barkun, Jeffrey; Besselink, Marc G.; Boggi, Ugo; Conlon, Kevin; Han, Ho Seong; Hansen, Paul; Kendrick, Michael L.; Kooby, David; Montagnini, Andre L.; Palanivelu, Chinnasamy; Wakabayashi, Go; Zeh, Herbert J.

    2017-01-01

    The first International conference on Minimally Invasive Pancreas Resection was arranged in conjunction with the annual meeting of the International Hepato-Pancreato-Biliary Association (IHPBA), in Sao Paulo, Brazil on April 19th 2016. The presented evidence and outcomes resulting from the session

  18. Management of invasive species

    DEFF Research Database (Denmark)

    Schou, Jesper Sølver; Jensen, Frank

    In this paper, we conduct a number of cost-benefit analyses to clarify whether the establishment of invasive species should be prevented or the damage of such species should be mitigated after introduction. We use the potential establishment of ragweed in Denmark as an empirical case. The main...... of information externalities, altruistic preferences, possible catastrophic events and ethical considerations....

  19. Locus of control and investment in risky assets

    NARCIS (Netherlands)

    Salamanca Acosta, Nicolas; de Grip, A.; Fouarge, Didier; Montizaan, Raymond

    2016-01-01

    We show that household heads with a strong internal economic locus of control are more likely to hold equity and hold a larger share of equity in their investment portfolio. This relation holds when we control for economic preferences and possible confounders such as financial literacy,

  20. The Influence of Locus of Control on Student Financial Behavior

    Science.gov (United States)

    Britt, Sonya; Cumbie, Julie A.; Bell, Mary M.

    2013-01-01

    Data on psychological influences of financial behaviors has not been well addressed in student populations, which is concerning given the high levels of general and financial stress experienced by college students. The findings of this study indicate that college students with an external locus of control exhibit the worst financial behaviors.…

  1. Dealing with Malfunction: Locus of Control in Web-Conferencing

    Science.gov (United States)

    Klebl, Michael

    2014-01-01

    This paper considers how students deal with malfunctions that occur during the use of web conferencing systems in learning arrangements. In a survey among participants in online courses that make use of a web-conferencing system (N = 129), the relationship between a preference for internal or external locus of control and the perception of…

  2. Influences of peer relations and locus of control on students ...

    African Journals Online (AJOL)

    Effort to checkmate extravagance and maximize gain is the focus of all organizations more in this period of global financial crisis. There is need therefore to checkmate unnecessary financial spending. This study examines the influence of the variables, peer relations and locus of control, on such spending among University ...

  3. Exploring Learner Autonomy: Language Learning Locus of Control in Multilinguals

    Science.gov (United States)

    Peek, Ron

    2016-01-01

    By using data from an online language learning beliefs survey (n?=?841), defining language learning experience in terms of participants' multilingualism, and using a domain-specific language learning locus of control (LLLOC) instrument, this article examines whether more experienced language learners can also be seen as more autonomous language…

  4. DNA marker mining of ILSTS035 microsatellite locus on ...

    Indian Academy of Sciences (India)

    Unknown

    We describe tests for detecting and locating quantitative trait loci (QTL) for traits in Hanwoo cattle. From results of a permutation test to detect QTL for marbling, we selected the microsatellite locus ILSTS035 on chromosome 6 for further analysis. K-means clustering analysis applied to five traits and nine DNA markers in ...

  5. automatic generation of root locus plots for linear time invariant

    African Journals Online (AJOL)

    user

    Design and analysis of control systems often become difficult due to the complexity of the system model and the design ... theory, it has equally been applied to classical .... open loop poles. Available algorithms for sketching this root locus can be categorized as follows: i. Direct Methods: These are the algorithms in which.

  6. Strengthening Locus Standi in Human Rights Litigation in Zimbabwe ...

    African Journals Online (AJOL)

    MJM Venter

    2016-05-30

    May 30, 2016 ... Declaration of Rights, its enforcement mechanisms, particularly those relating to locus standi (legal standing), posed a great challenge to human rights litigation in Zimbabwe. This is so because the Lancaster House Constitution adopted the traditional common law approach to standing. Under this.

  7. The Influence of Labor Market Discrimination on Locus of Control.

    Science.gov (United States)

    Becker, Brian E.; Krzystofiak, Frank J.

    1982-01-01

    Drawing on a national probability sample (N=2,857) of young men, used multiple regression analysis to estimate the effect of labor market discrimination on subsequent locus of control. Results indicated that perceptions of employment discrimination influenced the level of externality among Blacks, over and above racial identification. (Author/RC)

  8. New distal marker closely linked to the fragile X locus

    NARCIS (Netherlands)

    T. Hulsebos (Theo); B.A. Oostra (Ben); A. Broersen (Alexander); A. Smits; B.A. van Oost (B.); A. Westerveld (Andries)

    1991-01-01

    textabstractWe have isolated II-10, a new X-chromosomal probe that identifies a highly informative two-allele TaqI restriction fragment length polymorphism at locus DXS466. Using somatic cell hybrids containing distinct portions of the long arm of the X chromosome, we could localize DXS466 between

  9. Gender, Age and Locus of Control as Correlates of Remedial ...

    African Journals Online (AJOL)

    The study sought to explain remedial learners' attitude towards English language using three variables: gender, age and locus of control. Three properly validated instruments were used to collect data on the relevant variables from 385 remedial English learners randomly selected from 5 remedial education centers in ...

  10. Relationship Among Locus of Control, Self-concept, and Anxiety

    Science.gov (United States)

    Donovan, Dennis M.; And Others

    1975-01-01

    The purpose of the present research was to replicate O'Leary, et al.'s previous findings (EJ 100 528) and to test the hypothesis that the correlation between Rotter's Locus of Control scale and the Taylor Manifest Anxiety scale was moderated by neuroticism and negativism toward self. (Author/RK)

  11. Academic Anxiety, Locus of Control, and Achievement in Medical School.

    Science.gov (United States)

    Grover, Paul L.; Smith, Douglas U.

    1981-01-01

    Relationships among prior achievement, academic anxiety, locus of control, and performance in the first year of medical school were examined. Academic anxiety was found to be significantly related to first-year performance and when combined with a measure of prior achievement, resulted in a significant increase in prediction. (Author/MLW)

  12. Locus of Control-Levels of Death Anxiety Relationships.

    Science.gov (United States)

    Hayslip, Bert, Jr.; Stewart-Bussey, Duke

    1987-01-01

    Correlational analysis suggested interactions among aspects of locus of control and aspects of death fear varying along the death/dying, self/other, and overt/covert continua. These data enable a more complete understanding of the role that perceived controllability of life events play in determining individual reactions to one's own or another's…

  13. Analysis of the ABCA4 genomic locus in Stargardt disease

    DEFF Research Database (Denmark)

    Zernant, Jana; Xie, Yajing Angela; Ayuso, Carmen

    2014-01-01

    was designed to find the missing disease-causing ABCA4 variation by a combination of next-generation sequencing (NGS), array-Comparative Genome Hybridization (aCGH) screening, familial segregation and in silico analyses. The entire 140 kb ABCA4 genomic locus was sequenced in 114 STGD patients with one known...

  14. Locus of Control and Technology Adoption in Developing Country Agriculture

    DEFF Research Database (Denmark)

    Abay, Kibrom Araya; Blalock, Garrick; Berhane, Guush

    2017-01-01

    and psychological explanations for the low rates of adoption of profitable agricultural technologies in Sub-Saharan Africa. Our results highlight that improving farmers’ non-cognitive skills (locus of control) may facilitate technology adoption and agricultural transformation. More generally, the results suggest...

  15. New distal marker closely linked to the fragile X locus

    NARCIS (Netherlands)

    Hulsebos, T. J.; Oostra, B. A.; Broersen, S.; Smits, A.; van Oost, B. A.; Westerveld, A.

    1991-01-01

    We have isolated II-10, a new X-chromosomal probe that identifies a highly informative two-allele TaqI restriction fragment length polymorphism at locus DXS466. Using somatic cell hybrids containing distinct portions of the long arm of the X chromosome, we could localize DXS466 between DXS296 and

  16. Concept -Mapping, Students' Locus of Control and Gender as ...

    African Journals Online (AJOL)

    Concept -Mapping, Students' Locus of Control and Gender as Determinants of Nigerian High School Students' Achievement in Biology. ... Finally, teachers are enjoined to use the concept - mapping strategy in teaching both the male and female students because this method has been found to be effective in the teaching of ...

  17. Relationship between internet addiction and academic locus of ...

    African Journals Online (AJOL)

    The study identified the various internet activities engaged in by students in a Nigerian University and examined the relationship between internet addiction and their academic locus of control. The sample was made of 250 students selected from a University in Nigeria. An instrument tagged “Questionnaire on Students' ...

  18. Emotional Intelligence, Locus of Control and Conflict Handling Skills ...

    African Journals Online (AJOL)

    This study examined Emotional Intelligence, Locus of control and Conflict Handling Skills as Predictors of non-violent behaviours among University Students in South-Western Nigeria. The population was all the Nigerian University Students in the South-Western Nigerian out of which a sample of 1,000 participants were ...

  19. multidimensional health locus of control scales: applicability among

    African Journals Online (AJOL)

    2002-03-03

    Mar 3, 2002 ... Background: Primary preventive approaches are likely to be more effective if the motivational factors of health ... among the mostimportant motivational factors, commonly assessed with the multidimensional health locus of control scale ... assessing one internal and one external dimension. The MHLC scale ...

  20. Screening for genomic rearrangements at BRCA1 locus in Iranian ...

    Indian Academy of Sciences (India)

    2016-08-26

    Aug 26, 2016 ... Home; Journals; Journal of Genetics; Volume 92; Issue 1. Screening for genomic rearrangements at BRCA1 locus in Iranian women with breast cancer using multiplex ligation-dependent probe amplification. Vahid R. Yassaee Babak Emamalizadeh Mir Davood Omrani. Research Note Volume 92 Issue 1 ...

  1. Social support, locus of control, and psychological well-being

    NARCIS (Netherlands)

    van der Zee, KI; Buunk, BP; Sanderman, R

    1997-01-01

    Social support seems to be positively related to psychological well-being. Studies have shown that individual differences exist in the ability to mobilize and use sources of support. The current study focused on locus of control as a personality factor that might be related to this ability, In 2

  2. Alexandrov's Isodiametric Conjecture and the Cut Locus of a Surface

    Czech Academy of Sciences Publication Activity Database

    Freitas, P.; Krejčiřík, David

    2015-01-01

    Roč. 67, č. 3 (2015), s. 405-417 ISSN 0040-8735 R&D Projects: GA ČR GAP203/11/0701 Institutional support: RVO:61389005 Keywords : Alexantrov's conjecture * convex surface s * ellipsoids * cut locus * symmetrization Subject RIV: BE - Theoretical Physics Impact factor: 0.359, year: 2015

  3. Locus of control and learning strategies as predictors of academic ...

    African Journals Online (AJOL)

    The aim of the research was to determine the relationships which exist between academic success, learning strategies and locus of control. In order to achieve this aim a small-scale quantitative study, utilising two inventories, was done. The first measuring instrument is the Learning and Study Strategies Inventory, which is ...

  4. Relationship Among Achievement Motivation, Self-Esteem, Locus of ...

    African Journals Online (AJOL)

    The thrust of the study was to examine the relationship among achievement motivation, self-esteem, locus of control and academic performance of university students in a Nigerian University. The purpose was to determine the extent university student\\'s academic performance was influenced by these criterion variables.

  5. Influence of Locus Control on Real and Perceived Relationships ...

    African Journals Online (AJOL)

    They included the Nowicki-Strickland Internal – External Locus of Control Scale for children by Nowicki and Strickland (1973) and Emotional – Social Loneliness Inventory by Vincenzi and Grabosky, (1987). A cross sectional survey design was used while regression analysis and multivariate statistics were used in data ...

  6. The Locus of the Focus of a Rolling Parabola

    Science.gov (United States)

    Agarwal, Anurag; Marengo, James

    2010-01-01

    The catenary is usually introduced as the shape assumed by a hanging flexible cable. This is a "physical" description of a catenary. In this article we give a "geometrical" description of a catenary. Specifically we show that the catenary is the locus of the focus of a certain parabola as it rolls on the x-axis.

  7. Emotional intelligence and locus of control of adult patients with ...

    African Journals Online (AJOL)

    Background: This article investigates emotional intelligence and locus of control in an adult breast cancer population receiving treatment. Gaining insight into these constructs will contribute to improving breast cancer patients' psychological well-being and to reducing physical vulnerability to disease before and during ...

  8. Inferring relationships between pairs of individuals from locus heterozygosities

    Directory of Open Access Journals (Sweden)

    Spinetti Isabella

    2002-11-01

    Full Text Available Abstract Background The traditional exact method for inferring relationships between individuals from genetic data is not easily applicable in all situations that may be encountered in several fields of applied genetics. This study describes an approach that gives affordable results and is easily applicable; it is based on the probabilities that two individuals share 0, 1 or both alleles at a locus identical by state. Results We show that these probabilities (zi depend on locus heterozygosity (H, and are scarcely affected by variation of the distribution of allele frequencies. This allows us to obtain empirical curves relating zi's to H for a series of common relationships, so that the likelihood ratio of a pair of relationships between any two individuals, given their genotypes at a locus, is a function of a single parameter, H. Application to large samples of mother-child and full-sib pairs shows that the statistical power of this method to infer the correct relationship is not much lower than the exact method. Analysis of a large database of STR data proves that locus heterozygosity does not vary significantly among Caucasian populations, apart from special cases, so that the likelihood ratio of the more common relationships between pairs of individuals may be obtained by looking at tabulated zi values. Conclusions A simple method is provided, which may be used by any scientist with the help of a calculator or a spreadsheet to compute the likelihood ratios of common alternative relationships between pairs of individuals.

  9. Evolutionary process of a tetranucleotide microsatellite locus in ...

    Indian Academy of Sciences (India)

    2011-08-19

    Aug 19, 2011 ... Abstract. The evolutionary dynamics of the tetra-nucleotide microsatellite locus Spl-106 were investigated at the repeat and flanking sequences in 137 individuals of 15 Acipenseriform species, giving 93 homologous sequences, which were detected in 11 out of 15 species. Twenty-three haplotypes of ...

  10. AUTOMATIC GENERATION OF ROOT LOCUS PLOTS FOR LINEAR ...

    African Journals Online (AJOL)

    Design and analysis of control systems often become difficult due to the complexity of the system model and the design techniques involved. This paper presents the development of a Tools Box in Microsoft Excel for control engineer that uses root locus as a time domain technique for system design and analysis. The Tool ...

  11. Demographic Determinants of Locus of Control among Medical ...

    African Journals Online (AJOL)

    The Levenson Multidimensional Locus of Control Inventory and a Socio - demographic data collection sheet were used to collect data from 262 (183 males and 79 females) students selected through convenience sampling. Data were th analyzed using the 16th version of the SPPS. Percentages, means, t-test and ANOVA ...

  12. DNA marker mining of ILSTS035 microsatellite locus on ...

    Indian Academy of Sciences (India)

    We describe tests for detecting and locating quantitative trait loci (QTL) for traits in Hanwoo cattle. From results of a permutation test to detect QTL for marbling, we selected the microsatellite locus ILSTS035 on chromosome 6 for further analysis. -means clustering analysis applied to five traits and nine DNA markers in ...

  13. Influence of organisational climate and locus of control on job ...

    African Journals Online (AJOL)

    This study examined the influence of perceived organisational climate and locus of control on job satisfaction and turnover intentions of commercial bank workers in Benin, Edo State, Nigeria. To determine this, a 2X2 ANOVA was used to analyse the data. Results from a field study of 200 employees of 25 commercial banks ...

  14. Job Satisfaction and Locus of Control in an Academic Setting

    Science.gov (United States)

    Stachowiak, Bonni J.

    2010-01-01

    This study explored any relationships that existed between faculty members' locus of control and job satisfaction at a small, private, faith-based university. Two demographic variables were also analyzed in the findings: number of years teaching in higher education and tenure status. The job satisfaction instrument used was the Job in General…

  15. Sam Karlin and multi-locus population genetics.

    Science.gov (United States)

    Feldman, Marcus W

    2009-06-01

    Between 1967 and 1982, Sam Karlin made fundamental contributions to many areas of deterministic population genetic theory. This remembrance focuses on his work in multi-locus population genetics, primarily on the interaction between genotypic selection and the rate of recombination.

  16. Computer-aided root -locus numerical technique | Zubair | Nigerian ...

    African Journals Online (AJOL)

    ... which were analyzed, simplified and coded into computer programs. The geometric properties of the root-loci obtained with this technique are found to conform to those root described in the literature. Root-loci are drawn to scale instead of rough sketches. Keywords: control system, stability, transient response, root-locus, ...

  17. Determination of the yield locus by means of temperature measurement

    NARCIS (Netherlands)

    Banabic, D.; Huetink, Han

    2006-01-01

    The paper presents a theoretical background of the thermo-graphical method of determining the yield locus. The analytical expression of the temperature variation of the specimen deformed in the elastic state is determined starting from the first law of thermodynamics. The experimental method for

  18. Male-pattern baldness susceptibility locus at 20p11.

    NARCIS (Netherlands)

    Richards, J.B.; Yuan, X.; Geller, F.; Waterworth, D.; Bataille, V.; Glass, D.; Song, K.; Waeber, G.; Vollenweider, P.; Aben, K.K.H.; Kiemeney, L.A.L.M.; Walters, B.; Soranzo, N.; Thorsteinsdottir, U.; Kong, A.; Rafnar, T.; Deloukas, P.; Sulem, P.; Stefansson, H.; Stefansson, K.; Spector, T.D.; Mooser, V.

    2008-01-01

    We conducted a genome-wide association study for androgenic alopecia in 1,125 men and identified a newly associated locus at chromosome 20p11.22, confirmed in three independent cohorts (n = 1,650; OR = 1.60, P = 1.1 x 10(-14) for rs1160312). The one man in seven who harbors risk alleles at both

  19. [Relationship between work locus of control and occupational stress in oil workers].

    Science.gov (United States)

    Meng, Xian-Hai; He, Ya-Hui; Yu, Shan-Fa; Qi, Xiu-Ying

    2008-12-01

    To investigate general states of the work locus of control and explore the relationship between work locus of control and occupational stress in oil workers. 582 oil workers were investigated by using the General Questionnaire and Occupational Stress Measure Inventory. There were significant differences in WCLS score between two age groups (= 30 years old group and locus of control; values of role ambiguity, working prospect, depression and social support were higher in the group of external locus of control (P locus of control had positive relation with role ambiguity, working prospect, depression, and social support, and negative with interpersonal relationship, promotion, participation, task consistency, challenge, job satisfaction, mental health, self-esteem and coping strategies. In the regression analysis, work locus of control was the major predictive factor of work satisfaction. Work locus of control is associated with many occupational stress factors. The group of extrinsic work locus of control experience more stress in oil workers.

  20. DMPD: The Lps locus: genetic regulation of host responses to bacteriallipopolysaccharide. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 10669111 The Lps locus: genetic regulation of host responses to bacteriallipopolysaccharide. Qur...e The Lps locus: genetic regulation of host responses to bacteriallipopolysaccharide. Authors Qur

  1. Invasive Plants -- A Horticultural Perspective

    OpenAIRE

    Niemiera, Alexander Xavier, 1951-; Von Holle, Betsy

    2009-01-01

    This publication explains how nonnative invasive plants are harmful and why you should care, how to predict the invasive potential of a plant, and how gardeners and landscape professionals can make informed choices when choosing plants.

  2. Confirmation of 5p12 As a Susceptibility Locus for Progesterone-Receptor-Positive, Lower Grade Breast Cancer

    DEFF Research Database (Denmark)

    Milne, Roger L; Goode, Ellen L; García-Closas, Montserrat

    2011-01-01

    -negative disease; P(heterogeneity) = 2 × 10(-7)); heterogeneity by ER status was not observed (P = 0.2) once PR status was accounted for. The association was also stronger for lower grade tumors [per-allele OR (95% CI) = 1.20 (1.14-1.25), 1.13 (1.09-1.16), and 1.04 (0.99-1.08) for grade 1, 2, and 3/4, respectively...... Consortium. METHODS: Data were combined from 37 studies, including 40,972 invasive cases, 1,398 cases of ductal carcinoma in situ (DCIS), and 46,334 controls, all of white European ancestry, as well as 3,007 invasive cases and 2,337 controls of Asian ancestry. Associations overall and by tumor invasiveness......; P(trend) = 5 × 10(-7)]. CONCLUSION: 5p12 is a breast cancer susceptibility locus for PR-positive, lower grade breast cancer. Impact: Multicenter fine-mapping studies of this region are needed as a first step to identifying the causal variant or variants. Cancer Epidemiol Biomarkers Prev; 20...

  3. Locus of Control in Offenders and Alleged Offenders with Learning Disabilities

    Science.gov (United States)

    Goodman, Wendy; Leggett, Janice; Garrett, Tanya

    2007-01-01

    Locus of control can be a useful measure of treatment outcome in offenders from the general population. However, there is little information regarding locus of control and offenders with learning disabilities. Existing measures of locus of control use complex language and abstract ideas that may not be accessible to individuals in this group. A…

  4. On the Relation of Locus of Control and L2 Reading and Writing Achievement

    Science.gov (United States)

    Ghonsooly, Behzad; Shirvan, Majid Elahi

    2011-01-01

    Locus of control, a psychological construct, has been the focus of attention in recent decades. Psychologists have discussed the effect of locus of control on achieving life goals in social/psychological interactions. While learning a foreign language involves both social interactions and psychological processes, the role and relation of locus of…

  5. Reframing Student Affairs Leadership: An Analysis of Organizational Frames of Reference and Locus of Control

    Science.gov (United States)

    Tull, Ashley; Freeman, Jerrid P.

    2011-01-01

    Examined in this study were the identified frames of reference and locus of control used by 478 student affairs administrators. Administrator responses were examined to identify frames of reference most commonly used and their preference order. Locus of control most commonly used and the relationship between frames of reference and locus of…

  6. Parental Locus of Control and the Assessment of Children's Personality Characteristics.

    Science.gov (United States)

    Ollendick, Duane G.

    1979-01-01

    A study of fourth graders and their parents was conducted to determine the relationship between parents' locus of control and their children's locus of control, anxiety, intelligence, achievement, and behavioral adjustment. The relationship between mothers' locus of control and children's characteristics was more consistent than between fathers…

  7. Locus of Control, Field Dependence, and Stress Reactivity in Young Adult Males.

    Science.gov (United States)

    Schweibinz, Janet S.

    This study examined the potential relationships between locus of control, field dependence, and stress reactivity in a sample of young adult males (N=40). Locus of control, field dependence, and stress reactivity were measured by the Rotter Locus of Control Scale, the Embedded Figures Test, and the Life Events Survey, respectively. State stress…

  8. LES VARIANTES LEXICALES POUR LE MOT ESPADRILLES AU PARANÁ ET DANS LA RÉGION NORD-EST DU BRÉSIL: UNE ETUDE ETHNOLINGUISTIQUE

    Directory of Open Access Journals (Sweden)

    Vanderci de Andrade AGUILERA

    2013-12-01

    Full Text Available Cette étude concerne les variantes lexicales pour le mot espadrilles dans l’Etat du Paraná et dans la région Nord-Est du Brésil, sous un regard ethnolinguistique. Le corpus est composé par les donnés obtenues à partir de la question numéro 276 du Questionnaire Semantique-Lexical de l’Atlas Linguistique du Paraná (ALPR, dont l’auteur est le professeur Vanderci de Andrade Aguilera (1994, de l’Université de l’Etat de Londrina, autant que les variantes lexicales pour le mot espadrilles trouvées dans deux ouvrages littéraires d’auteurs originaires du Nord-Est du Brésil – Fogo Morto, de José Lins do Rego (2009 et Vidas Secas, de Graciliano Ramos (1969. Dans ces livres, les espadrilles jouent un rôle fondamental, tout en reflétant son importance dans le vestiaire de cette région, du moins jusqu’à moitié du XXème siècle. On rechercha des éventuelles ressemblances ou différences existentes entre les variantes lexicales de la chaussure mentionnée par les informateurs “paranaenses” et le modèle cité dans les ouvrages des écrivains Rego et Ramos. Dans les deuxs sources – la linguistique et la littéraire – on privilégia l’analyse semantique des unités lexicales et le contexte dans lequel elles ont été enregistrées. L’étude démontra que l’unité lexicale espadrilles et ses variantes phonétiques similaires dans les deux corpora, aussi que les variantes lexicales populaires présentes dans l’Atlas Linguistique du Paraná (ALPR. En dépit des simitudes l’esthétique et la fonction des espadrilles ne sont pas les mêmes dans les localitées concernées.

  9. Le Brésil au cœur des stratégies spatiales du recrutement des clubs européens de football

    Directory of Open Access Journals (Sweden)

    Bertrand Piraudeau

    2009-10-01

    Full Text Available Depuis la fin des années 1990, le nombre de footballeurs brésiliens évoluant dans les clubs professionnels internationaux augmente constamment. Les principaux championnats européens (Allemagne, Angleterre, Espagne, France, Italie et Portugal sont très courtisés par les joueurs brésiliens. L'histoire des relations entre les territoires et les stratégies spatiales du recrutement développées par les clubs de football européens font apparaître un système productif de joueurs brésiliens et des canaux migratoires très organisés entre l'Europe et le Brésil.Depuis la fin des années 1990, le nombre de footballeurs brésiliens évoluant dans les clubs professionnels internationaux augmente constamment. Les principaux championnats européens (Allemagne, Angleterre, Espagne, France, Italie et Portugal sont très courtisés par les joueurs brésiliens. L'histoire des relations entre les territoires et les stratégies spatiales du recrutement développées par les clubs de football européens font apparaître un système productif de joueurs brésiliens et des canaux migratoires très organisés entre l'Europe et le Brésil.Desde o fim dos anos 1990, o número de jogadores de futebol brasileiros que jogam nos clubes profissionais internacionais aumenta constantemente. Os principais campeonatos europeus (Alemanha, Inglaterra, Espanha, França, Itália e Portugal são  muito procurados pelos jogadores brasileiros. A história das relações entre os territórios e as estratégias espaciais de recrutamento desenvolvidas pelos clubes de futebol europeus indica um sistema produtivo de jogadores brasileiros e canais migratórios muito organizados entre a Europa e o Brasil.Since the end of the 1990s, the number of Brazilian footballers playing in the international professional clubs increases constantly. The principal European championships (Germany, England, Spain, France, Italy and Portugal are very courted by the Brazilian players. The history

  10. "Birdlime" technique using TachoSil tissue sealing sheet soaked with fibrin glue for sutureless vessel transposition in microvascular decompression: operative technique and nuances.

    Science.gov (United States)

    Otani, Naoki; Toyooka, Terushige; Fujii, Kazuya; Kumagai, Kosuke; Takeuchi, Satoru; Tomiyama, Arata; Nakao, Yasuaki; Yamamoto, Takuji; Wada, Kojiro; Mori, Kentaro

    2017-08-11

    OBJECTIVE Microvascular decompression (MVD) is effective for the treatment of trigeminal neuralgia (TN), hemifacial spasm (HFS), and glossopharyngeal neuralgia. The transposition technique is the standard procedure to avoid adhesions and granuloma around the decompression site but is more complex and difficult to perform than the interposition technique. The authors describe a simple and safe MVD transposition procedure they call the "birdlime" technique, which uses a tissue glue-coated collagen sponge soaked with fibrin glue, and the results of this technique. METHODS The authors retrospectively reviewed the medical charts and radiographic findings of 27 consecutive patients with TN (8 patients) and HFS (19 patients) who, between January 2012 and December 2015, had undergone an MVD transposition procedure utilizing a tissue glue-coated collagen sponge (TachoSil tissue sealing sheet) soaked with fibrin glue (Tisseel 2-component fibrin sealant, vapor heated). Offending arteries among the patients with TN were the superior cerebellar artery (SCA) in 5 patients, the SCA and anterior inferior cerebellar artery (AICA) in 2, and the AICA in 1. Those among the patients with HFS were the vertebral artery (VA) in 3 patients, the VA and AICA in 4, the VA and posterior inferior cerebellar artery (PICA) in 3, the PICA in 4, the AICA in 1, the AICA-PICA in 3, and the PICA and AICA in 1. Operations were performed according to the Jannetta procedure. The offending artery was transposed and fixed to the dura mater of the petrous bone using TachoSil pieces soaked with fibrin glue. Postoperative constructive interference in steady-state MRI was performed to evaluate the change in the position of the offending artery. RESULTS Transposition of the offending artery was easily and safely performed in all patients. All patients had total remission of symptoms directly after the procedure. No severe complications occurred. The postoperative course was uneventful. No recurrences, adhesions

  11. Minimally Invasive Abdominal Surgery

    OpenAIRE

    Richardson, William S.; Carter, Kristine M.; Fuhrman, George M.; Bolton, John S.; Bowen, John C.

    2000-01-01

    In the last decade, laparoscopy has been the most innovative surgical movement in general surgery. Minimally invasive surgery performed through a few small incisions, laparoscopy is the standard of care for the treatment of gallbladder disease and the gold standard for the treatment of reflux disease. The indications for a laparoscopic approach to abdominal disease continue to increase, and many diseases may be treated with laparoscopic techniques. At Ochsner, laparoscopic techniques have dem...

  12. Plant invasions: Merging the concepts of species invasiveness and community invasibility

    Czech Academy of Sciences Publication Activity Database

    Richardson, D. M.; Pyšek, Petr

    2006-01-01

    Roč. 30, č. 3 (2006), s. 409-431 ISSN 0309-1333 Institutional research plan: CEZ:AV0Z60050516 Keywords : plant invasions * species invasiveness * community invasibility Subject RIV: EF - Botanics Impact factor: 1.278, year: 2006

  13. Metodología para el cálculo del nivel integrado de seguridad (sil, aplicada al caso: estudio de un sistema instrumentado de seguridad (sis de nivel en calderas industriales de alta presión

    Directory of Open Access Journals (Sweden)

    Walter Gastelbondo-Barragan

    2008-01-01

    Full Text Available In this paper develops the methodology for calculating the Safety Integrity Level of level at a boiler of industrial high pressure. The Safety Integrity Level (SIL, is derived from reliability dynamics representation of each of the elements that are part of safety instrumented function, through which is obtained the Probability of Failure on Demand, being this the basic parameter for determining Safety Integrity Level of a Safety Instrumented System.

  14. Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer.

    Science.gov (United States)

    Bojesen, Stig E; Pooley, Karen A; Johnatty, Sharon E; Beesley, Jonathan; Michailidou, Kyriaki; Tyrer, Jonathan P; Edwards, Stacey L; Pickett, Hilda A; Shen, Howard C; Smart, Chanel E; Hillman, Kristine M; Mai, Phuong L; Lawrenson, Kate; Stutz, Michael D; Lu, Yi; Karevan, Rod; Woods, Nicholas; Johnston, Rebecca L; French, Juliet D; Chen, Xiaoqing; Weischer, Maren; Nielsen, Sune F; Maranian, Melanie J; Ghoussaini, Maya; Ahmed, Shahana; Baynes, Caroline; Bolla, Manjeet K; Wang, Qin; Dennis, Joe; McGuffog, Lesley; Barrowdale, Daniel; Lee, Andrew; Healey, Sue; Lush, Michael; Tessier, Daniel C; Vincent, Daniel; Bacot, Françis; Vergote, Ignace; Lambrechts, Sandrina; Despierre, Evelyn; Risch, Harvey A; González-Neira, Anna; Rossing, Mary Anne; Pita, Guillermo; Doherty, Jennifer A; Alvarez, Nuria; Larson, Melissa C; Fridley, Brooke L; Schoof, Nils; Chang-Claude, Jenny; Cicek, Mine S; Peto, Julian; Kalli, Kimberly R; Broeks, Annegien; Armasu, Sebastian M; Schmidt, Marjanka K; Braaf, Linde M; Winterhoff, Boris; Nevanlinna, Heli; Konecny, Gottfried E; Lambrechts, Diether; Rogmann, Lisa; Guénel, Pascal; Teoman, Attila; Milne, Roger L; Garcia, Joaquin J; Cox, Angela; Shridhar, Vijayalakshmi; Burwinkel, Barbara; Marme, Frederik; Hein, Rebecca; Sawyer, Elinor J; Haiman, Christopher A; Wang-Gohrke, Shan; Andrulis, Irene L; Moysich, Kirsten B; Hopper, John L; Odunsi, Kunle; Lindblom, Annika; Giles, Graham G; Brenner, Hermann; Simard, Jacques; Lurie, Galina; Fasching, Peter A; Carney, Michael E; Radice, Paolo; Wilkens, Lynne R; Swerdlow, Anthony; Goodman, Marc T; Brauch, Hiltrud; Garcia-Closas, Montserrat; Hillemanns, Peter; Winqvist, Robert; Dürst, Matthias; Devilee, Peter; Runnebaum, Ingo; Jakubowska, Anna; Lubinski, Jan; Mannermaa, Arto; Butzow, Ralf; Bogdanova, Natalia V; Dörk, Thilo; Pelttari, Liisa M; Zheng, Wei; Leminen, Arto; Anton-Culver, Hoda; Bunker, Clareann H; Kristensen, Vessela; Ness, Roberta B; Muir, Kenneth; Edwards, Robert; Meindl, Alfons; Heitz, Florian; Matsuo, Keitaro; du Bois, Andreas; Wu, Anna H; Harter, Philipp; Teo, Soo-Hwang; Schwaab, Ira; Shu, Xiao-Ou; Blot, William; Hosono, Satoyo; Kang, Daehee; Nakanishi, Toru; Hartman, Mikael; Yatabe, Yasushi; Hamann, Ute; Karlan, Beth Y; Sangrajrang, Suleeporn; Kjaer, Susanne Krüger; Gaborieau, Valerie; Jensen, Allan; Eccles, Diana; Høgdall, Estrid; Shen, Chen-Yang; Brown, Judith; Woo, Yin Ling; Shah, Mitul; Azmi, Mat Adenan Noor; Luben, Robert; Omar, Siti Zawiah; Czene, Kamila; Vierkant, Robert A; Nordestgaard, Børge G; Flyger, Henrik; Vachon, Celine; Olson, Janet E; Wang, Xianshu; Levine, Douglas A; Rudolph, Anja; Weber, Rachel Palmieri; Flesch-Janys, Dieter; Iversen, Edwin; Nickels, Stefan; Schildkraut, Joellen M; Silva, Isabel Dos Santos; Cramer, Daniel W; Gibson, Lorna; Terry, Kathryn L; Fletcher, Olivia; Vitonis, Allison F; van der Schoot, C Ellen; Poole, Elizabeth M; Hogervorst, Frans B L; Tworoger, Shelley S; Liu, Jianjun; Bandera, Elisa V; Li, Jingmei; Olson, Sara H; Humphreys, Keith; Orlow, Irene; Blomqvist, Carl; Rodriguez-Rodriguez, Lorna; Aittomäki, Kristiina; Salvesen, Helga B; Muranen, Taru A; Wik, Elisabeth; Brouwers, Barbara; Krakstad, Camilla; Wauters, Els; Halle, Mari K; Wildiers, Hans; Kiemeney, Lambertus A; Mulot, Claire; Aben, Katja K; Laurent-Puig, Pierre; Altena, Anne Mvan; Truong, Thérèse; Massuger, Leon F A G; Benitez, Javier; Pejovic, Tanja; Perez, Jose Ignacio Arias; Hoatlin, Maureen; Zamora, M Pilar; Cook, Linda S; Balasubramanian, Sabapathy P; Kelemen, Linda E; Schneeweiss, Andreas; Le, Nhu D; Sohn, Christof; Brooks-Wilson, Angela; Tomlinson, Ian; Kerin, Michael J; Miller, Nicola; Cybulski, Cezary; Henderson, Brian E; Menkiszak, Janusz; Schumacher, Fredrick; Wentzensen, Nicolas; Le Marchand, Loic; Yang, Hannah P; Mulligan, Anna Marie; Glendon, Gord; Engelholm, Svend Aage; Knight, Julia A; Høgdall, Claus K; Apicella, Carmel; Gore, Martin; Tsimiklis, Helen; Song, Honglin; Southey, Melissa C; Jager, Agnes; den Ouweland, Ans M Wvan; Brown, Robert; Martens, John W M; Flanagan, James M; Kriege, Mieke; Paul, James; Margolin, Sara; Siddiqui, Nadeem; Severi, Gianluca; Whittemore, Alice S; Baglietto, Laura; McGuire, Valerie; Stegmaier, Christa; Sieh, Weiva; Müller, Heiko; Arndt, Volker; Labrèche, France; Gao, Yu-Tang; Goldberg, Mark S; Yang, Gong; Dumont, Martine; McLaughlin, John R; Hartmann, Arndt; Ekici, Arif B; Beckmann, Matthias W; Phelan, Catherine M; Lux, Michael P; Permuth-Wey, Jenny; Peissel, Bernard; Sellers, Thomas A; Ficarazzi, Filomena; Barile, Monica; Ziogas, Argyrios; Ashworth, Alan; Gentry-Maharaj, Aleksandra; Jones, Michael; Ramus, Susan J; Orr, Nick; Menon, Usha; Pearce, Celeste L; Brüning, Thomas; Pike, Malcolm C; Ko, Yon-Dschun; Lissowska, Jolanta; Figueroa, Jonine; Kupryjanczyk, Jolanta; Chanock, Stephen J; Dansonka-Mieszkowska, Agnieszka; Jukkola-Vuorinen, Arja; Rzepecka, Iwona K; Pylkäs, Katri; Bidzinski, Mariusz; Kauppila, Saila; Hollestelle, Antoinette; Seynaeve, Caroline; Tollenaar, Rob A E M; Durda, Katarzyna; Jaworska, Katarzyna; Hartikainen, Jaana M; Kosma, Veli-Matti; Kataja, Vesa; Antonenkova, Natalia N; Long, Jirong; Shrubsole, Martha; Deming-Halverson, Sandra; Lophatananon, Artitaya; Siriwanarangsan, Pornthep; Stewart-Brown, Sarah; Ditsch, Nina; Lichtner, Peter; Schmutzler, Rita K; Ito, Hidemi; Iwata, Hiroji; Tajima, Kazuo; Tseng, Chiu-Chen; Stram, Daniel O; van den Berg, David; Yip, Cheng Har; Ikram, M Kamran; Teh, Yew-Ching; Cai, Hui; Lu, Wei; Signorello, Lisa B; Cai, Qiuyin; Noh, Dong-Young; Yoo, Keun-Young; Miao, Hui; Iau, Philip Tsau-Choong; Teo, Yik Ying; McKay, James; Shapiro, Charles; Ademuyiwa, Foluso; Fountzilas, George; Hsiung, Chia-Ni; Yu, Jyh-Cherng; Hou, Ming-Feng; Healey, Catherine S; Luccarini, Craig; Peock, Susan; Stoppa-Lyonnet, Dominique; Peterlongo, Paolo; Rebbeck, Timothy R; Piedmonte, Marion; Singer, Christian F; Friedman, Eitan; Thomassen, Mads; Offit, Kenneth; Hansen, Thomas V O; Neuhausen, Susan L; Szabo, Csilla I; Blanco, Ignacio; Garber, Judy; Narod, Steven A; Weitzel, Jeffrey N; Montagna, Marco; Olah, Edith; Godwin, Andrew K; Yannoukakos, Drakoulis; Goldgar, David E; Caldes, Trinidad; Imyanitov, Evgeny N; Tihomirova, Laima; Arun, Banu K; Campbell, Ian; Mensenkamp, Arjen R; van Asperen, Christi J; van Roozendaal, Kees E P; Meijers-Heijboer, Hanne; Collée, J Margriet; Oosterwijk, Jan C; Hooning, Maartje J; Rookus, Matti A; van der Luijt, Rob B; Os, Theo A Mvan; Evans, D Gareth; Frost, Debra; Fineberg, Elena; Barwell, Julian; Walker, Lisa; Kennedy, M John; Platte, Radka; Davidson, Rosemarie; Ellis, Steve D; Cole, Trevor; Bressac-de Paillerets, Brigitte; Buecher, Bruno; Damiola, Francesca; Faivre, Laurence; Frenay, Marc; Sinilnikova, Olga M; Caron, Olivier; Giraud, Sophie; Mazoyer, Sylvie; Bonadona, Valérie; Caux-Moncoutier, Virginie; Toloczko-Grabarek, Aleksandra; Gronwald, Jacek; Byrski, Tomasz; Spurdle, Amanda B; Bonanni, Bernardo; Zaffaroni, Daniela; Giannini, Giuseppe; Bernard, Loris; Dolcetti, Riccardo; Manoukian, Siranoush; Arnold, Norbert; Engel, Christoph; Deissler, Helmut; Rhiem, Kerstin; Niederacher, Dieter; Plendl, Hansjoerg; Sutter, Christian; Wappenschmidt, Barbara; Borg, Ake; Melin, Beatrice; Rantala, Johanna; Soller, Maria; Nathanson, Katherine L; Domchek, Susan M; Rodriguez, Gustavo C; Salani, Ritu; Kaulich, Daphne Gschwantler; Tea, Muy-Kheng; Paluch, Shani Shimon; Laitman, Yael; Skytte, Anne-Bine; Kruse, Torben A; Jensen, Uffe Birk; Robson, Mark; Gerdes, Anne-Marie; Ejlertsen, Bent; Foretova, Lenka; Savage, Sharon A; Lester, Jenny; Soucy, Penny; Kuchenbaecker, Karoline B; Olswold, Curtis; Cunningham, Julie M; Slager, Susan; Pankratz, Vernon S; Dicks, Ed; Lakhani, Sunil R; Couch, Fergus J; Hall, Per; Monteiro, Alvaro N A; Gayther, Simon A; Pharoah, Paul D P; Reddel, Roger R; Goode, Ellen L; Greene, Mark H; Easton, Douglas F; Berchuck, Andrew; Antoniou, Antonis C; Chenevix-Trench, Georgia; Dunning, Alison M

    2013-04-01

    TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ∼480 SNPs at the TERT locus in breast (n = 103,991), ovarian (n = 39,774) and BRCA1 mutation carrier (n = 11,705) cancer cases and controls. Leukocyte telomere measurements were also available for 53,724 participants. Most associations cluster into three independent peaks. The minor allele at the peak 1 SNP rs2736108 associates with longer telomeres (P = 5.8 × 10(-7)), lower risks for estrogen receptor (ER)-negative (P = 1.0 × 10(-8)) and BRCA1 mutation carrier (P = 1.1 × 10(-5)) breast cancers and altered promoter assay signal. The minor allele at the peak 2 SNP rs7705526 associates with longer telomeres (P = 2.3 × 10(-14)), higher risk of low-malignant-potential ovarian cancer (P = 1.3 × 10(-15)) and greater promoter activity. The minor alleles at the peak 3 SNPs rs10069690 and rs2242652 increase ER-negative (P = 1.2 × 10(-12)) and BRCA1 mutation carrier (P = 1.6 × 10(-14)) breast and invasive ovarian (P = 1.3 × 10(-11)) cancer risks but not via altered telomere length. The cancer risk alleles of rs2242652 and rs10069690, respectively, increase silencing and generate a truncated TERT splice variant.

  15. Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

    Science.gov (United States)

    Bojesen, Stig E; Pooley, Karen A; Johnatty, Sharon E; Beesley, Jonathan; Michailidou, Kyriaki; Tyrer, Jonathan P; Edwards, Stacey L; Pickett, Hilda A; Shen, Howard C; Smart, Chanel E; Hillman, Kristine M; Mai, Phuong L; Lawrenson, Kate; Stutz, Michael D; Lu, Yi; Karevan, Rod; Woods, Nicholas; Johnston, Rebecca L; French, Juliet D; Chen, Xiaoqing; Weischer, Maren; Nielsen, Sune F; Maranian, Melanie J; Ghoussaini, Maya; Ahmed, Shahana; Baynes, Caroline; Bolla, Manjeet K; Wang, Qin; Dennis, Joe; McGuffog, Lesley; Barrowdale, Daniel; Lee, Andrew; Healey, Sue; Lush, Michael; Tessier, Daniel C; Vincent, Daniel; Bacot, Françis; Vergote, Ignace; Lambrechts, Sandrina; Despierre, Evelyn; Risch, Harvey A; González-Neira, Anna; Rossing, Mary Anne; Pita, Guillermo; Doherty, Jennifer A; Álvarez, Nuria; Larson, Melissa C; Fridley, Brooke L; Schoof, Nils; Chang-Claude, Jenny; Cicek, Mine S; Peto, Julian; Kalli, Kimberly R; Broeks, Annegien; Armasu, Sebastian M; Schmidt, Marjanka K; Braaf, Linde M; Winterhoff, Boris; Nevanlinna, Heli; Konecny, Gottfried E; Lambrechts, Diether; Rogmann, Lisa; Guénel, Pascal; Teoman, Attila; Milne, Roger L; Garcia, Joaquin J; Cox, Angela; Shridhar, Vijayalakshmi; Burwinkel, Barbara; Marme, Frederik; Hein, Rebecca; Sawyer, Elinor J; Haiman, Christopher A; Wang-Gohrke, Shan; Andrulis, Irene L; Moysich, Kirsten B; Hopper, John L; Odunsi, Kunle; Lindblom, Annika; Giles, Graham G; Brenner, Hermann; Simard, Jacques; Lurie, Galina; Fasching, Peter A; Carney, Michael E; Radice, Paolo; Wilkens, Lynne R; Swerdlow, Anthony; Goodman, Marc T; Brauch, Hiltrud; García-Closas, Montserrat; Hillemanns, Peter; Winqvist, Robert; Dürst, Matthias; Devilee, Peter; Runnebaum, Ingo; Jakubowska, Anna; Lubinski, Jan; Mannermaa, Arto; Butzow, Ralf; Bogdanova, Natalia V; Dörk, Thilo; Pelttari, Liisa M; Zheng, Wei; Leminen, Arto; Anton-Culver, Hoda; Bunker, Clareann H; Kristensen, Vessela; Ness, Roberta B; Muir, Kenneth; Edwards, Robert; Meindl, Alfons; Heitz, Florian; Matsuo, Keitaro; du Bois, Andreas; Wu, Anna H; Harter, Philipp; Teo, Soo-Hwang; Schwaab, Ira; Shu, Xiao-Ou; Blot, William; Hosono, Satoyo; Kang, Daehee; Nakanishi, Toru; Hartman, Mikael; Yatabe, Yasushi; Hamann, Ute; Karlan, Beth Y; Sangrajrang, Suleeporn; Kjaer, Susanne Krüger; Gaborieau, Valerie; Jensen, Allan; Eccles, Diana; Høgdall, Estrid; Shen, Chen-Yang; Brown, Judith; Woo, Yin Ling; Shah, Mitul; Azmi, Mat Adenan Noor; Luben, Robert; Omar, Siti Zawiah; Czene, Kamila; Vierkant, Robert A; Nordestgaard, Børge G; Flyger, Henrik; Vachon, Celine; Olson, Janet E; Wang, Xianshu; Levine, Douglas A; Rudolph, Anja; Weber, Rachel Palmieri; Flesch-Janys, Dieter; Iversen, Edwin; Nickels, Stefan; Schildkraut, Joellen M; Silva, Isabel Dos Santos; Cramer, Daniel W; Gibson, Lorna; Terry, Kathryn L; Fletcher, Olivia; Vitonis, Allison F; van der Schoot, C Ellen; Poole, Elizabeth M; Hogervorst, Frans B L; Tworoger, Shelley S; Liu, Jianjun; Bandera, Elisa V; Li, Jingmei; Olson, Sara H; Humphreys, Keith; Orlow, Irene; Blomqvist, Carl; Rodriguez-Rodriguez, Lorna; Aittomäki, Kristiina; Salvesen, Helga B; Muranen, Taru A; Wik, Elisabeth; Brouwers, Barbara; Krakstad, Camilla; Wauters, Els; Halle, Mari K; Wildiers, Hans; Kiemeney, Lambertus A; Mulot, Claire; Aben, Katja K; Laurent-Puig, Pierre; van Altena, Anne M; Truong, Thérèse; Massuger, Leon F A G; Benitez, Javier; Pejovic, Tanja; Perez, Jose Ignacio Arias; Hoatlin, Maureen; Zamora, M Pilar; Cook, Linda S; Balasubramanian, Sabapathy P; Kelemen, Linda E; Schneeweiss, Andreas; Le, Nhu D; Sohn, Christof; Brooks-Wilson, Angela; Tomlinson, Ian; Kerin, Michael J; Miller, Nicola; Cybulski, Cezary; Henderson, Brian E; Menkiszak, Janusz; Schumacher, Fredrick; Wentzensen, Nicolas; Marchand, Loic Le; Yang, Hannah P; Mulligan, Anna Marie; Glendon, Gord; Engelholm, Svend Aage; Knight, Julia A; Høgdall, Claus K; Apicella, Carmel; Gore, Martin; Tsimiklis, Helen; Song, Honglin; Southey, Melissa C; Jager, Agnes; van den Ouweland, Ans M W; Brown, Robert; Martens, John W M; Flanagan, James M; Kriege, Mieke; Paul, James; Margolin, Sara; Siddiqui, Nadeem; Severi, Gianluca; Whittemore, Alice S; Baglietto, Laura; McGuire, Valerie; Stegmaier, Christa; Sieh, Weiva; Müller, Heiko; Arndt, Volker; Labrèche, France; Gao, Yu-Tang; Goldberg, Mark S; Yang, Gong; Dumont, Martine; McLaughlin, John R; Hartmann, Arndt; Ekici, Arif B; Beckmann, Matthias W; Phelan, Catherine M; Lux, Michael P; Permuth-Wey, Jenny; Peissel, Bernard; Sellers, Thomas A; Ficarazzi, Filomena; Barile, Monica; Ziogas, Argyrios; Ashworth, Alan; Gentry-Maharaj, Aleksandra; Jones, Michael; Ramus, Susan J; Orr, Nick; Menon, Usha; Pearce, Celeste L; Brüning, Thomas; Pike, Malcolm C; Ko, Yon-Dschun; Lissowska, Jolanta; Figueroa, Jonine; Kupryjanczyk, Jolanta; Chanock, Stephen J; Dansonka-Mieszkowska, Agnieszka; Jukkola-Vuorinen, Arja; Rzepecka, Iwona K; Pylkäs, Katri; Bidzinski, Mariusz; Kauppila, Saila; Hollestelle, Antoinette; Seynaeve, Caroline; Tollenaar, Rob A E M; Durda, Katarzyna; Jaworska, Katarzyna; Hartikainen, Jaana M; Kosma, Veli-Matti; Kataja, Vesa; Antonenkova, Natalia N; Long, Jirong; Shrubsole, Martha; Deming-Halverson, Sandra; Lophatananon, Artitaya; Siriwanarangsan, Pornthep; Stewart-Brown, Sarah; Ditsch, Nina; Lichtner, Peter; Schmutzler, Rita K; Ito, Hidemi; Iwata, Hiroji; Tajima, Kazuo; Tseng, Chiu-Chen; Stram, Daniel O; van den Berg, David; Yip, Cheng Har; Ikram, M Kamran; Teh, Yew-Ching; Cai, Hui; Lu, Wei; Signorello, Lisa B; Cai, Qiuyin; Noh, Dong-Young; Yoo, Keun-Young; Miao, Hui; Iau, Philip Tsau-Choong; Teo, Yik Ying; McKay, James; Shapiro, Charles; Ademuyiwa, Foluso; Fountzilas, George; Hsiung, Chia-Ni; Yu, Jyh-Cherng; Hou, Ming-Feng; Healey, Catherine S; Luccarini, Craig; Peock, Susan; Stoppa-Lyonnet, Dominique; Peterlongo, Paolo; Rebbeck, Timothy R; Piedmonte, Marion; Singer, Christian F; Friedman, Eitan; Thomassen, Mads; Offit, Kenneth; Hansen, Thomas V O; Neuhausen, Susan L; Szabo, Csilla I; Blanco, Ignacio; Garber, Judy; Narod, Steven A; Weitzel, Jeffrey N; Montagna, Marco; Olah, Edith; Godwin, Andrew K; Yannoukakos, Drakoulis; Goldgar, David E; Caldes, Trinidad; Imyanitov, Evgeny N; Tihomirova, Laima; Arun, Banu K; Campbell, Ian; Mensenkamp, Arjen R; van Asperen, Christi J; van Roozendaal, Kees E P; Meijers-Heijboer, Hanne; Collée, J Margriet; Oosterwijk, Jan C; Hooning, Maartje J; Rookus, Matti A; van der Luijt, Rob B; van Os, Theo A M; Evans, D Gareth; Frost, Debra; Fineberg, Elena; Barwell, Julian; Walker, Lisa; Kennedy, M John; Platte, Radka; Davidson, Rosemarie; Ellis, Steve D; Cole, Trevor; Paillerets, Brigitte Bressac-de; Buecher, Bruno; Damiola, Francesca; Faivre, Laurence; Frenay, Marc; Sinilnikova, Olga M; Caron, Olivier; Giraud, Sophie; Mazoyer, Sylvie; Bonadona, Valérie; Caux-Moncoutier, Virginie; Toloczko-Grabarek, Aleksandra; Gronwald, Jacek; Byrski, Tomasz; Spurdle, Amanda B; Bonanni, Bernardo; Zaffaroni, Daniela; Giannini, Giuseppe; Bernard, Loris; Dolcetti, Riccardo; Manoukian, Siranoush; Arnold, Norbert; Engel, Christoph; Deissler, Helmut; Rhiem, Kerstin; Niederacher, Dieter; Plendl, Hansjoerg; Sutter, Christian; Wappenschmidt, Barbara; Borg, Åke; Melin, Beatrice; Rantala, Johanna; Soller, Maria; Nathanson, Katherine L; Domchek, Susan M; Rodriguez, Gustavo C; Salani, Ritu; Kaulich, Daphne Gschwantler; Tea, Muy-Kheng; Paluch, Shani Shimon; Laitman, Yael; Skytte, Anne-Bine; Kruse, Torben A; Jensen, Uffe Birk; Robson, Mark; Gerdes, Anne-Marie; Ejlertsen, Bent; Foretova, Lenka; Savage, Sharon A; Lester, Jenny; Soucy, Penny; Kuchenbaecker, Karoline B; Olswold, Curtis; Cunningham, Julie M; Slager, Susan; Pankratz, Vernon S; Dicks, Ed; Lakhani, Sunil R; Couch, Fergus J; Hall, Per; Monteiro, Alvaro N A; Gayther, Simon A; Pharoah, Paul D P; Reddel, Roger R; Goode, Ellen L; Greene, Mark H; Easton, Douglas F; Berchuck, Andrew; Antoniou, Antonis C; Chenevix-Trench, Georgia; Dunning, Alison M

    2013-01-01

    TERT-locus single nucleotide polymorphisms (SNPs) and leucocyte telomere measures are reportedly associated with risks of multiple cancers. Using the iCOGs chip, we analysed ~480 TERT-locus SNPs in breast (n=103,991), ovarian (n=39,774) and BRCA1 mutation carrier (11,705) cancer cases and controls. 53,724 participants have leucocyte telomere measures. Most associations cluster into three independent peaks. Peak 1 SNP rs2736108 minor allele associates with longer telomeres (P=5.8×10−7), reduced estrogen receptor negative (ER-negative) (P=1.0×10−8) and BRCA1 mutation carrier (P=1.1×10−5) breast cancer risks, and altered promoter-assay signal. Peak 2 SNP rs7705526 minor allele associates with longer telomeres (P=2.3×10−14), increased low malignant potential ovarian cancer risk (P=1.3×10−15) and increased promoter activity. Peak 3 SNPs rs10069690 and rs2242652 minor alleles increase ER-negative (P=1.2×10−12) and BRCA1 mutation carrier (P=1.6×10−14) breast and invasive ovarian (P=1.3×10−11) cancer risks, but not via altered telomere length. The cancer-risk alleles of rs2242652 and rs10069690 respectively increase silencing and generate a truncated TERT splice-variant. PMID:23535731

  16. Por entre memórias e silêncios: representações literárias das guerras em Angola e Moçambique

    Directory of Open Access Journals (Sweden)

    Carmen Lucia Tindó Ribeiro Secco

    2008-12-01

    Full Text Available Representações da guerra em poetas de Angola e Moçambique. Lutas anticoloniais e utopias libertárias. A guerra civil e o clima de desestabilização e desencanto. Fraturas e descontinuidades históricas. Os sonhos fissurados e as distopias sociais. Catástrofe e melancolia. Memória e esquecimento. Alegorias e metáforas. A busca de exorcização das experiências da barbárie por meio de elaborados exercícios poéticos: palavras e silêncios em carne viva. Os horrores da guerra repensados e ressignificados pela beleza e pelos prazeres da arte. A poesia lírica como expressão não apenas de subjetividades individuais, mas também de rupturas e impactos sociais.Palavras-chave: Memória; Guerra; Poesia; Angola; Moçambique.

  17. João Pereira da Silva, Francisco Adolfo de Varnhagen et les malheurs de l'histoire moderne du Brésil

    Directory of Open Access Journals (Sweden)

    Armelle Enders

    2010-06-01

    Full Text Available Peu d´historiens se sont consacrés à l´histoire du Brésil indépendant sous l`Empire et João Manuel Pereira da Silva et Francisco Adolfo de Varnhagen constituent deux exceptions à cette règle. Véritable succès de libraire, le livre de Pereira da Silva História da Fundação do Império Brasileiro, en 7 gros volumes publiés á partir de 1864, est cependant  vite discrédité, ainsi que son auteur, qui tombe dans l´oubli. Varnhagen ne doit pas sa gloire à ses travaux sur l´indépendance , édités longtemps après sa mort. Ces mésaventures historiographiques posent le problème de la légitimité de l´histoire contemporaine et les difficiles rapports de celle-ci avec la politique et la monarchie brésilienne.

  18. Nas sombras da Ditadura: as marcas da violência em Uma varanda sobre o silêncio e De amor y de sombra

    Directory of Open Access Journals (Sweden)

    Cristiane Aparecida da Rosa Rossi

    2015-06-01

    Full Text Available Com base no estudo dos romances Uma varanda sobre o silêncio, do escritor brasileiro Josué Montello (1917-2006, e De amor y de sombra, da escritora chilena Isabel Allende (1942, pretendemos compreender a maneira como o autoritarismo político instaurado no Brasil, a partir de 1964 a 1985, conforma a vida do indivíduo, de modo a cercear sua liberdade, impedindo-o de agir livremente. Com base nisso, dizemos que o estado autoritário age como coator e intensificador do sofrimento humano, de modo a tornar o cidadão comum incapaz de governar sua vida, sem que a opressão condicione sua conduta. Dessa forma, a fim de realizarmos este estudo, faremos uma análise comparativa dos referidos romances, aliando-os à pesquisa bibliográfica. Os resultados apontarão para os desaparecimentos de Mário Júlio e de Evangelina Ranquileo como exemplos, casos de violência comumente encontrados no Brasil e no Chile, no período que sucedeu o golpe militar de 1964.

  19. La gestión de las materias primas silíceas en el Pirineo Occidental: la ocupación Magdaleniense de Berroberria (Urdax, Navarra

    Directory of Open Access Journals (Sweden)

    Irantzu ELORRIETA BAIGORRI, Antonio TARRIÑO VINAGRE

    2016-01-01

    Full Text Available La cueva de Berroberria es uno de los yacimientos más representativos del Magdaleniense en el Pirineo Occidental. Se presentan en este caso los resultados del estudio de procedencia de las materias primas líticas empleadas por los grupos del Magdaleniense Medio (alrededor de 14500 cal. BC. La metodología propuesta incluye análisis petrológicos y mineralógicos, mediante los que se identifican los principales afloramientos de sílex de los que se abastecieron. Se ha constatado así la explotación mayoritaria de los recursos silíceos más cercanos, como es el sílex de Flysch, junto con la de recursos regionales, como los sílex de Tercis o Chalosse, y siendo minoritarios pero de gran interés los aportes de materias primas extra-regionales de posible procedencia noraquitana. La gestión de cada una de estas rocas, al igual que su representación, es diferente; pero concuerda con la dinámica observada para esta cronología.

  20. Écrire pour vivre, vivre pour écrire: un récit autobiographique au Brésil

    Directory of Open Access Journals (Sweden)

    Maria Luisa Scaramella

    2010-02-01

    Full Text Available Cet article traite du rôle de l’écriture autobiografique dans la vie de Maura Lopes Cançado. Maura a écrit un livre, l´Hospice c´est Dieu, espèce de journal intime autobiographique publiée en 1965 au Brésil. Maura commence sa carrière en écrivant des contes pour le Jornal do Brasil, en 1958, dans le supplément littéraire. Son désir pour être reconnue donne lieu à des crises de nerfs, le conduisant à s´interner en hopitaux psychiatriques. Son livre est le fruit de ses nombreux internements, il fournit un portrait de sa condition: la patiente qui subit les pratiques d´une institution psychiatrique violente et décadente; l´individu qui puise dans l´écriture autobiographique son lien le plus profond avec la vie, son fil d´Ariane, qui le tire du labyrinthe. Cette écriture marquée par la souffrance, sert de pont entre Maura et le monde. Si écrire est le fil qui le relie à la vie, à l’autre, à la société, à mesure que Maura s´éloigne de l´écriture, son histoire devient tragique. Le je et l’autre s´éloignent.

  1. Relations among psychosocial development, locus of control, and time orientation.

    Science.gov (United States)

    Baldo, R; Harris, M; Crandall, J

    1975-06-01

    The research concerned relations among development at Erikson's first six stages of psychosocial development, locus of control, and several measures of time orientation. The investigation involved 68 female and 65 male high school and university students. Development at Erikson's Stages 1,3, 4, and 5 was significantly related to the I-E Scale, with positive development being associated with internal control. Locus of control was also related to sex and age. Women were found to be more externally controlled than men. Internal control was associated with increasing age over the range from 15 to 25 years. Development at each of Erikson's first five stages was significantly correlated with one or more measures of tempiral relatedness, or integration of perceived past, present, and future time zones. Other measures of time orientation failed to show consistent relations to psychosocial development.

  2. Relationships among locus of control, self-concept, and anxiety.

    Science.gov (United States)

    Donovan, D M; Smyth, L; Paige, A B; O'Leary, M R

    1975-10-01

    Sixty male alcoholic inpatients were administered the Locus of Control scale (IE), the Activity Preference Questionnaire (APQ), the Manifest Anxiety scale (MAS), and the Tennessee Self Concept scale (TSCS). Ss defined as having an external locus of control appeared significantly more anxious than internal Ss on the MAS; however, no differences were found between groups on the APQ or TSCS scales. The self-report (MAS) and nonobtrusive (APQ) measures of anxiety were not correlated significantly. A differential pattern of correlations was found between the MAS and APQ and TCSC subscale scores. The obtained correlations support the contention that the MAS may measure more accurately a dimension of neuroticism and/or negative self-concept rather than anxiety. Further research appears necessary to investigate the internal consistency and dimensionality of the MAS.

  3. Refined localization of the Prieto-syndrome locus

    Energy Technology Data Exchange (ETDEWEB)

    Martinez, F.; Prieto, F. [Unidad de Genetica, Valencia (Spain); Gal, A. [Universitaets-Krankenhaus Eppendorf, Hamburg (Germany)

    1996-07-12

    PRS designates the locus for a syndromal form of X-linked mental retardation (Prieto syndrome) characterized by minor facial anomalies, ear malformation, abnormal growth of teeth, clinodactyly, sacral dimple, patellar luxation, malformation of lower limbs, abnormalities of the fundus of the eye, and subcortical cerebral atrophy. Linkage analysis localized the disease locus between DXS84 (Xp21.1) and DXS255. Here we present additional linkage data that provide further support and refinement of this localization. Individual III-18 gave birth to a male, currently aged 2 7/12 years, who clearly shows delayed psychomotor development. He began to walk at 23 months and his speech is delayed. In addition, he shows the characteristic facial anomalies, {open_quotes}dysplastic{close_quotes} ears, sacral dimple, and clinodactyly, as do all other affected males in this family. 7 refs., 1 tab.

  4. Danish surgeons' views on minimally invasive surgery

    DEFF Research Database (Denmark)

    Edwards, Hellen; Jørgensen, Lars Nannestad

    2014-01-01

    and distributed electronically via e-mail to a total of 1253 members of The Danish Society of Surgeons and The Danish Society of Young Surgeons. RESULTS: In total, 352 (approximately 30%) surgeons completed the questionnaire, 54.4% were over 50 years of age, and 76.6% were men. When choosing surgery, the most...... important factors taken into consideration were the risk of complication and short convalescence, whereas the least important factors were cosmesis and option of local anaesthesia. If the surgeons themselves were to undergo cholecystectomy, 35.5% would choose SILS, and 14.5% would choose NOTES provided...... become standard techniques for cholecystectomy within 6 years. CONCLUSIONS: The importance of risk of complications has not surprisingly a high priority among surgeons in this questionnaire. Why this is has to be investigated further before implementing SILS and NOTES as standard of care....

  5. Surfeit locus gene homologs are widely distributed in invertebrate genomes.

    OpenAIRE

    Armes, N; Fried, M

    1996-01-01

    The mouse Surfeit locus contains six sequence-unrelated genes (Surf-1 to -6) arranged in the tightest gene cluster so far described for mammals. The organization and juxtaposition of five of the Surfeit genes (Surf-1 to -5) are conserved between mammals and birds, and this may reflect a functional or regulatory requirement for the gene clustering. We have undertaken an evolutionary study to determine whether the Surfeit genes are conserved and clustered in invertebrate genomes. Drosophila mel...

  6. The immunoglobulin heavy chain locus in the platypus (Ornithorhynchus anatinus).

    Science.gov (United States)

    Gambón-Deza, F; Sánchez-Espinel, C; Magadán-Mompó, S

    2009-08-01

    Immunoglobulins loci in mammals are well known to be organized within a translocon, however their origin remains unresolved. Four of the five classes of immunoglobulins described in humans and rodents (immunoglobulins M, G, E and A-IgM, IgG, IgE and IgA) were found in marsupials and monotremes (immunoglobulin D-IgD was not found) thus showing that the genomic structure of antibodies in mammals has remained constant since its origin. We have recently described the genomic organization of the immunoglobulin heavy chain locus in reptiles (IGHM, IGHD and IGHY). These data and the characterization of the IGH locus in platypus (Ornithorhynchus anatinus), allow us to elucidate the changes that took place in this genomic region during evolution from reptile to mammal. Thus, by using available genome data, we were able to detect that platypus IGH locus contains reptilian and mammalian genes. Besides having an IGHD that is very similar to the one in reptiles and an IGHY, they also present the mammal specific antibody genes IGHG and IGHE, in addition to IGHA. We also detected a pseudogene that originated by recombination between the IGHD and the IGHM (similar to the IGHD2 found in Eublepharis macularius). The analysis of the IGH locus in platypus shows that IGHY was duplicated, firstly by evolving into IGHE and then into IGHG. The IGHA of the platypus has a complex origin, and probably arose by a process of recombination between the IGHM and the IGHY. We detected about 44 VH genes (25 were already described), most of which comprise a single group. When we compared these VH genes with those described in Anolis carolinensis, we find that there is an evolutionary relationship between the VH genes of platypus and the reptilian Group III genes. These results suggest that a fast VH turnover took place in platypus and this gave rise to a family with a high VH gene number and the disappearance of the earlier VH families.

  7. A note on the locus and function of formal gender

    OpenAIRE

    Picallo, M. Carme

    2017-01-01

    This paper examines some aspects of nominal inflection. It focuses in particular on noun classification with evidence drawn mainly from Spanish where noun classification surfaces as formal Gender. Under a minimalist lens, this feature is a puzzling grammatical element because it seems uncongenial to the idea of optimal design. I examine some syntactic evidence to assess the syntactic locus of Gender features in nominal structures, and conjecture that noun classification simply externalizes so...

  8. Locus-specific view of flax domestication history

    OpenAIRE

    Fu, Yong-Bi; Diederichsen, Axel; Allaby, Robin G

    2012-01-01

    Crop domestication has been inferred genetically from neutral markers and increasingly from specific domestication-associated loci. However, some crops are utilized for multiple purposes that may or may not be reflected in a single domestication-associated locus. One such example is cultivated flax (Linum usitatissimum L.), the earliest oil and fiber crop, for which domestication history remains poorly understood. Oil composition of cultivated flax and pale flax (L. bienne Mill.) indicates th...

  9. Characterization of a Multipeptide Lantibiotic Locus in Streptococcus pneumoniae

    Directory of Open Access Journals (Sweden)

    Natalie Maricic

    2016-01-01

    Full Text Available Bacterial communities are established through a combination of cooperative and antagonistic interactions between the inhabitants. Competitive interactions often involve the production of antimicrobial substances, including bacteriocins, which are small antimicrobial peptides that target other community members. Despite the nearly ubiquitous presence of bacteriocin-encoding loci, inhibitory activity has been attributed to only a small fraction of gene clusters. In this study, we characterized a novel locus (the pld locus in the pathogen Streptococcus pneumoniae that drives the production of a bacteriocin called pneumolancidin, which has broad antimicrobial activity. The locus encodes an unusual tandem array of four inhibitory peptides, three of which are absolutely required for antibacterial activity. The three peptide sequences are similar but appear to play distinct roles in regulation and inhibition. A modification enzyme typically found in loci encoding a class of highly modified bacteriocins called lantibiotics was required for inhibitory activity. The production of pneumolancidin is controlled by a two-component regulatory system that is activated by the accumulation of modified peptides. The locus is located on a mobile element that has been found in many pneumococcal lineages, although not all elements carry the pld genes. Intriguingly, a minimal region containing only the genes required for pneumolancidin immunity was found in several Streptococcus mitis strains. The pneumolancidin-producing strain can inhibit nearly all pneumococci tested to date and provided a competitive advantage in vivo. These peptides not only represent a unique strategy for bacterial competition but also are an important resource to guide the development of new antimicrobials.

  10. 'Locus of control', health-related quality of life, emotional distress and disability in Parkinson's disease.

    Science.gov (United States)

    Rizza, Federica; Gison, Annalisa; Bonassi, Stefano; Dall'Armi, Valentina; Tonto, Francesca; Giaquinto, Salvatore

    2017-06-01

    This cross-sectional study evaluated locus of control and its subscales in Parkinson's disease. A total of 50 consecutive Parkinson's disease participants and 50 healthy volunteers (control group) were enrolled. External locus of control was significantly higher in Parkinson's disease participants, whereas internal locus of control had no significant differences. External locus of control and internal locus of control were correlated in control group, but not in Parkinson's disease. In Parkinson's disease participants, external locus of control was negatively associated with health-related quality of life as well as positively associated with emotional distress and disease severity (but not with disability). After adjusting to confound variables, the associations remained. On the other hand, internal locus of control was negatively associated with depression.

  11. The Effects of Locus of Control and Task Difficulty on Procrastination.

    Science.gov (United States)

    Janssen, Tracy; Carton, John S

    1999-12-01

    The authors investigated the effects of locus of control expectancies and task difficulty on procrastination. Forty-two college students were administered an academic locus of control scale and a task that was similar to a typical college homework assignment. The students were randomly assigned to 1 of 2 task difficulty levels. Although none of the results involving task difficulty was significant, several results involving locus of control were significant. Specifically, analyses revealed that students with internal locus of control expectancies tended to begin working on the assignment sooner than students with external locus of control expectancies. In addition, students with internal locus of control completed and returned the assignment sooner than students with external locus of control. The results are discussed within the context of J. B. Rotter's (1966, 1975, 1982) social learning theory.

  12. Population genetics of the HRAS1 minisatellite locus

    Energy Technology Data Exchange (ETDEWEB)

    Devlin, B.; Risch, N. (Yale Univ., New Haven, CT (United States)); Krontiris, T. (Tufts Univ., Boston, MA (United States) New England Medical Center Hospital, Boston, MA (United States))

    1993-12-01

    Several years ago it was reported that rare HRAS1 VNTR alleles occurred more frequently in US Caucasian cancer patients than in unaffected controls. Such an association, in theory, could be caused by undetected population heterogeneity. Also, in a study clearly relevant to this issue, it was recently reported that significant deviations from Hardy-Weinberg equilibrium exist at this locus in a sample of US Caucasians. These considerations motivate population genetic analysis of the HRAS1 locus. From published studies of the HRAS1 VNTR locus, which classified alleles into types, the authors found only small differences in the allele frequency distributions of samples from various European nations, although there were larger differences among ethnic groups (African American, Caucasian, and Oriental). In an analysis of variation of rare-allele frequencies among samples from four European nations, most of the variance was attributable to molecular methodology, and very little of the variance was accounted for by nationality. In addition, the authors showed that mixture of European subpopulations should result in only minor deviations from expected genotype proportions in a Caucasian database and demonstrated that there was no significant deviation from Hardy-Weinberg equilibrium in the HRAS1 data. 35 refs., 4 tabs.

  13. Genetic analysis of the claret locus of Drosophila melanogaster

    International Nuclear Information System (INIS)

    Sequeira, W.; Nelson, C.R.; Szauter, P.

    1989-01-01

    The claret (ca) locus of Drosophila melanogaster comprises two separately mutable domains, one responsible for eye color and one responsible for proper disjunction of chromosomes in meiosis and early cleavage divisions. Previously isolated alleles are of three types: (1) alleles of the claret (ca) type that affect eye color only, (2) alleles of the claret-nondisjunctional (ca nd ) type that affect eye color and chromosome behavior, and (3) a meiotic mutation, non-claret disjunctional (ncd), that affects chromosome behavior only. In order to investigate the genetic structure of the claret locus, the authors have isolated 19 radiation-induced alleles of claret on the basis of the eye color phenotype. Two of these 19 new alleles are of the ca nd type, while 17 are of the ca type, demonstrating that the two domains do not often act as a single target for mutagenesis. This suggests that the two separately mutable functions are likely to be encoded by separate or overlapping genes rather than by a single gene. One of the new alleles of the ca nd type is a chromosome rearrangement with a breakpoint at the position of the claret locus. If this breakpoint is the cause of the mutant phenotype and there are no other mutations associated with the rearrangement, the two functions must be encoded by overlapping genes

  14. Origin of allelic diversity in antirrhinum S locus RNases.

    Science.gov (United States)

    Xue, Y; Carpenter, R; Dickinson, H G; Coen, E S

    1996-01-01

    In many plant species, self-incompatibility (SI) is genetically controlled by a single multiallelic S locus. Previous analysis of S alleles in the Solanaceae, in which S locus ribonucleases (S RNases) are responsible for stylar expression of SI, has demonstrated that allelic diversity predated speciation within this family. To understand how allelic diversity has evolved, we investigated the molecular basis of gametophytic SI in Antirrhinum, a member of the Scrophulariaceae, which is closely related to the Solanaceae. We have characterized three Antirrhinum cDNAs encoding polypeptides homologous to S RNases and shown that they are encoded by genes at the S locus. RNA in situ hybridization revealed that the Antirrhinum S RNase are primarily expressed in the stylar transmitting tissue. This expression is consistent with their proposed role in arresting the growth of self-pollen tubes. S alleles from the Scrophulariaceae form a separate group from those of the Solanaceae, indicating that new S alleles have been generated since these families separated (approximately 40 million years). We propose that the recruitment of an ancestral RNase gene into SI occurred during an early stage of angiosperm evolution and that, since that time, new alleles subsequently have arisen at a low rate. PMID:8672882

  15. Minimally Invasive Parathyroidectomy

    Directory of Open Access Journals (Sweden)

    Lee F. Starker

    2011-01-01

    Full Text Available Minimally invasive parathyroidectomy (MIP is an operative approach for the treatment of primary hyperparathyroidism (pHPT. Currently, routine use of improved preoperative localization studies, cervical block anesthesia in the conscious patient, and intraoperative parathyroid hormone analyses aid in guiding surgical therapy. MIP requires less surgical dissection causing decreased trauma to tissues, can be performed safely in the ambulatory setting, and is at least as effective as standard cervical exploration. This paper reviews advances in preoperative localization, anesthetic techniques, and intraoperative management of patients undergoing MIP for the treatment of pHPT.

  16. Locus de Controle e escolha do método anticoncepcional Locus de Control y método anticonceptivo elegido Locus of Control and choice of contraceptive method

    Directory of Open Access Journals (Sweden)

    Aline Salheb Alves

    2007-06-01

    Full Text Available Objetivou-se avaliar a relação entre o Locus de Controle e o tipo de método contraceptivo escolhido. Foi utilizada a Escala Multidimensional de Locus de Controle de Levenson e entrevistadas 191 mulheres. As usuárias de preservativo masculino apresentaram maior Internalidade do que as usuárias de injetável mensal. Quanto ao locus Externalidade Outros Poderosos, as usuárias de implante apresentavam menor externalidade do que as usuárias de preservativo masculino, laqueadura, injetável trimestral e DIU. Considerando-se o locus Externalidade Acaso, as usuárias de implante apresentaram menores escores do que as mulheres que optaram pela laqueadura, injetável trimestral e DIU. Observou-se ainda, menor Externalidade Acaso entre as usuárias de injetável mensal em relação às mulheres que fizeram opção pelo injetável trimestral.El objetivo es validar la relación entre el Locus de Control y el tipo de método anticonceptivo elegido. Fue usada la Escala Multidimensional de Locus de Control de Levenson. Fueron entrevistadas 191 mujeres. Las usuarias de condón masculino presentaron Internalidad más grande que las usuarias de inyectable mensual. Considerado el Locus Externalidad - Otro poderoso, las usuarias de implante presentaron menor externalidad de que las usuarias de condón masculino, laqueadura, inyectable trimestral y DIU. Considerado el Locus Externalidad - Quizá, las usuarias del implante presentaron menores resultados que las mujeres que eligieron por la laqueadura, inyectable trimestral y DIU. Se observo que las mujeres usuarias de inyectable mensual presentaron menor Externalidad - Quizá que las mujeres usuarias de inyectable trimestral.The purpose was to assess the relationship between locus of control and the contraceptive method chosen. It was used the Levenson's Multidimensional Locus of Control Scale and 191 women was interviewed. Users of male condoms presented greater Internality than the monthly contraceptive

  17. The Locus Control Region Is Necessary for Gene Expression in the Human β-Globin Locus but Not the Maintenance of an Open Chromatin Structure in Erythroid Cells

    Science.gov (United States)

    Reik, Andreas; Telling, Agnes; Zitnik, Galynn; Cimbora, Daniel; Epner, Elliot; Groudine, Mark

    1998-01-01

    Studies in many systems have led to the model that the human β-globin locus control region (LCR) regulates the transcription, chromatin structure, and replication properties of the β-globin locus. However the precise mechanisms of this regulation are unknown. We have developed strategies to use homologous recombination in a tissue culture system to examine how the LCR regulates the locus in its natural chromosomal environment. Our results show that when the functional components of the LCR, as defined by transfection and transgenic studies, are deleted from the endogenous β-globin locus in an erythroid background, transcription of all β-globin genes is abolished in every cell. However, formation of the remaining hypersensitive site(s) of the LCR and the presence of a DNase I-sensitive structure of the β-globin locus are not affected by the deletion. In contrast, deletion of 5′HS5 of the LCR, which has been suggested to serve as an insulator, has only a minor effect on β-globin transcription and does not influence the chromatin structure of the locus. These results show that the LCR as currently defined is not necessary to keep the locus in an “open” conformation in erythroid cells and that even in an erythroid environment an open locus is not sufficient to permit transcription of the β-like globin genes. PMID:9742116

  18. Cell invasion through basement membrane

    OpenAIRE

    Morrissey, Meghan A; Hagedorn, Elliott J; Sherwood, David R

    2013-01-01

    Cell invasion through basement membrane is an essential part of normal development and physiology, and occurs during the pathological progression of human inflammatory diseases and cancer. F-actin-rich membrane protrusions, called invadopodia, have been hypothesized to be the “drill bits” of invasive cells, mediating invasion through the dense, highly cross-linked basement membrane matrix. Though studied in vitro for over 30 y, invadopodia function in vivo has remained elusive. We have recent...

  19. Pre-invasion history and demography shape the genetic variation in the insecticide resistance-related acetylcholinesterase 2 gene in the invasive Colorado potato beetle

    Directory of Open Access Journals (Sweden)

    Piiroinen Saija

    2013-01-01

    Full Text Available Abstract Background Invasive pest species offers a unique opportunity to study the effects of genetic architecture, demography and selection on patterns of genetic variability. Invasive Colorado potato beetle (Leptinotarsa decemlineata populations have experienced a rapid range expansion and intense selection by insecticides. By comparing native and invasive beetle populations, we studied the origins of organophosphate (OP resistance-associated mutations in the acetylcholinesterase 2 (AChE2 gene, and the role of selection and demography on its genetic variability. Results Analysis of three Mexican, two US and five European populations yielded a total of 49 haplotypes. Contrary to the expectations all genetic variability was associated with a point mutation linked to insecticide resistance (S291G, this mutation was found in 100% of Mexican, 95% of US and 71% of European beetle sequences analysed. Only two susceptible haplotypes, genetically very differentiated, were found, one in US and one in Europe. The genetic variability at the AChE2 gene was compared with two other genes not directly affected by insecticide selection, diapause protein 1 and juvenile hormone esterase. All three genes showed reduction in genetic variability indicative of a population bottleneck associated with the invasion. Conclusions Stochastic effects during invasion explain most of the observed patterns of genetic variability at the three genes investigated. The high frequency of the S291G mutation in the AChE2 gene among native populations suggests this mutation is the ancestral state and thus, either a pre-adaptation of the beetle for OP resistance or the AChE2 is not the major gene conferring OP resistance. The long historical association with host plant alkaloids together with recombination may have contributed to the high genetic variation at this locus. The genetic diversity in the AChE2 locus of the European beetles, in turn, strongly reflects founder effects

  20. Examining the relationship between health locus of control and God Locus of Health Control: Is God an internal or external source?

    Science.gov (United States)

    Boyd, Joni M; Wilcox, Sara

    2017-11-01

    For many people, the influence of believing in a higher power can elicit powerful effects. This study examined the relationship between God control, health locus of control, and frequency of religious attendance within 838 college students through online surveys. Regression analysis showed that chance and external locus of control and frequency of religious attendance were significant and positive predictors of God Locus of Health Control. The association of powerful others external locus of control and God Locus of Health Control differed by race (stronger in non-Whites than Whites) and somewhat by gender (stronger in women than men). For some people, the role of a supreme being, or God, should be considered when designing programs for improving health behaviors.

  1. A comparison of non-invasive versus invasive methods of ...

    African Journals Online (AJOL)

    Puneet Khanna

    for Hb estimation from the laboratory [total haemoglobin mass (tHb)] and arterial blood gas (ABG) machine (aHb), using ... A comparison of non-invasive versus invasive methods of haemoglobin estimation in patients undergoing intracranial surgery. 161 .... making decisions for blood transfusions based on these results.

  2. Invasive v. non-invasive blood pressure measurements the ...

    African Journals Online (AJOL)

    A reasonable correlation exists between invasive and noninvasive methods of measuring systemic blood pressure. However, there are frequent individual differences between these methods and these variations have often caused the validity of the non-invasive measurement to be questioned. The hypothesis that certain ...

  3. Pobreza objetiva e subjetiva no Brasil Objective and subjective poverty in Brazil Pauvreté objective et subjective au Brésil

    Directory of Open Access Journals (Sweden)

    Antonio Marcio Buainain

    2011-11-01

    Full Text Available Este trabalho destina-se à análise da pobreza no Brasil, medida a partir de indicadores objetivos de disponibilidade de rendimentos per capita e de avaliações subjetivas de suficiência de renda e quantidade de alimentos consumidos. Atenção especial é dada às diferenças territoriais, seja entre estados brasileiros ou entre áreas urbanas e rurais. A análise baseia-se em resultados da Pesquisa sobre Orçamentos Familiares (POF do Instituto Brasileiro de Geografia e Estatística (IBGE para os anos de 2002/2003 e 2008/2009. De maneira geral, os resultados indicam uma substancial redução dos indicadores de pobreza, sobretudo daqueles associados às condições mais severas de insuficiência e nas regiões mais vulneráveis do país. A análise também constata que pessoas com rendimentos semelhantes tendem a estar mais satisfeitas com a quantidade de renda e de alimentos nas áreas rurais, embora os percentuais de insuficiência sejam superiores no conjunto dessas populações.This paper analyzes poverty in Brazil, measured by objective indicator of per capita income and subjective indicators of income and food insufficiency. Analyses highlight spatial differences, both differences between States and differences between urban and rural areas. Analyses are based on results of the Brazilian Pesquisa de Orçamentos Familiares (POF 2002/2003 and 2008/2009. Overall, results show a substantial reduction of the level of poverty in Brazil, specially for those related to more severe conditions of income and food insufficiency and in the more vulnerable regions. Analyses also suggest that people with similar income are more likely to declare income and food sufficiency in rural areas, although the percent of insufficiency is higher in the rural areas.Cet article analyse la pauvreté au Brésil, mesurée par indicateurs objectif de revenu per capita et indicateurs subjectifs d'insuffisance de revenus et d'alimentation. Analyses mettent en

  4. The PICS Technique: A Novel Approach for Residual Curvature Correction During Penile Prosthesis Implantation in Patients With Severe Peyronie's Disease Using the Collagen Fleece TachoSil.

    Science.gov (United States)

    Hatzichristodoulou, Georgios

    2018-03-01

    Correction of residual curvature during inflatable penile prosthesis (IPP) implantation in patients with Peyronie's disease (PD) by plaque incision and grafting is a common approach. To present a novel technique for residual curvature correction during IPP implantation using collagen fleece (TachoSil, Baxter Healthcare Corp, Deerfield, IL, USA). After the IPP (Titan Touch, Coloplast, Minneapolis, MN, USA) is placed, the implant is inflated maximally. When residual curvature exceeds 40°, the PICS (penile implant in combination with the Sealing technique) technique is performed. The device is deflated, and a circumcising skin incision and penile degloving are performed. After elevation of the neurovascular bundle, the device is reinflated maximally. Plaque incision is performed at the point of maximum curvature using electrocautery. This leads to penile straightening because the tension is removed. In the next step, the defect of the tunica is closed with collagen fleece, which sticks to the tunica and defect without any sutures needed. The neurovascular bundle is reapproximated and the Buck fascia is closed. This is followed by closure of penile skin. Primary outcome measurements were straightening rates, operative times, 5-item International Index of Erectile Function (IIEF-5) scores at follow-up, immediate and late complications, and patient satisfaction. The PICS technique was applied to 15 patients. Mean patient age was 61.7 years (52-79 years). Mean residual curvature after IPP was 66.7° (50-90°). Mean operative time was 117.3 minutes (100-140 minutes). Mean follow-up was 15.1 months (1-29 months). 12 of 15 patients (80%) showed a totally straight penis. 3 patients (20%) had residual curvature of 10° at follow-up, which did not interfere with sexual intercourse. Mean IIEF-5 score at follow-up was 24.2 (22-25). No immediate or late complications occurred. All patients were satisfied with the surgical outcomes. This novel technique prevents puncture or

  5. Avaliação de fontes e de extratores de silício no solo Evaluation of sources and extractors of silicon in the soil

    Directory of Open Access Journals (Sweden)

    Hamilton Seron Pereira

    2007-02-01

    Full Text Available O objetivo deste trabalho foi avaliar extratores e fontes de silício (Si na cultura do arroz em Neossolo Quartzarênico em casa de vegetação. O delineamento experimental foi feito em esquema fatorial (26x7 inteiramente casualizado com 25 fontes de silício, aplicadas à dose de 250 kg ha-1 de Si e a testemunha, e 7 extratores de Si no solo. Tratamentos adicionais com 125, 375 e 500 kg ha-1 de Si foram aplicados com wollastonita. Depois de 90 dias do plantio, foi avaliada a produção de matéria seca da parte aérea e os teores de Si no solo e na planta. A fonte que proporcionou maior teor de Si às plantas de arroz foi sílica gel, e a pior fonte foi a MB-4. Os extratores apresentaram aumento linear do teor de Si no solo com o incremento das doses de wollastonita. Entre os tratamentos, a maior extração de Si ocorreu com o ácido acético; o cloreto de cálcio foi o extrator com a melhor correlação. O carbonato de amônio e o acetato de amônio, além de apresentarem correlações próximas às do cloreto de cálcio, tiveram ainda uma melhor distribuição dos pontos, o que discriminou melhor as variações entre as diferentes fontes de Si.The objective of this work was to evaluate silicon extractors and sources in the culture of the rice in a Quartzipsamment soil in a greenhouse. The experiment was completely randomized as a factorial design (26x7, comprising 25 silicon sources with 250 kg ha-1 of Si applied, and the control, as well as 7 silicon extractors in the soil. Additional treatments with 125, 375 and 500 kg ha-1 of Si were applied with wollastonite. Ninety days after sowing, the yielded dry matter of aerial parts and the soil and plant tissue Si content were determined. The source that provided higher Si absorption to the plants of rice was gel silicon, and the source that provided lower absorption was the MB-4. The extractors presented increased linear content of Si in the soil with the increment of doses of wollastonite. Among

  6. Algumas indagações sobre o silêncio em torno da 6ª Conferência Nacional de Educação

    Directory of Open Access Journals (Sweden)

    Maria Juraci Maia Cavalcanti

    2012-06-01

    Full Text Available  O presente artigo trata de uma investigação sobre a 6ª Conferência Nacional de Educação ­ocorrida em Fortaleza, no ano de 1934, sob a coordenação do então diretor da Instrução Pública do Ceará, Joaquim Moreira de Sousa. A pesquisa foi instigada pelo silêncio em tomo da mesma por parte da historiografia educacional brasileira. Buscou-se recuperar o significado que teve para o meio educacional local, a representação de educadores que recebeu, bem como, o teor do debate político ali desencadeado e a especificidade do seu relatório final para, com esses elementos, melhor compreender o papel efetivo que teve aquela Conferência na posterior definição de um Plano Nacional de Educação. Palavras-chave: conferência nacional de educação, instrução pública, história local.   Abstract The present article is about an investigation on the 6th National Conference of Education - held in Fortaleza, in the year 1934, under the co-ordination of the director of the Public Education Department of Ceará, Joaquim Moreira de Sousa. Urged by the silence of the Brazilian historiography for education around it, aiming to rescue its significance to the local educational environment, the presence of influent representatives of the educational arena which participated on it, as well as, the content of the political debate there occurred, and the uniqueness of its final report, so that, with such elements, better understand the effective role which such Conference performed on the definition of a National Education Plan later on. Keywords: national conference for education, public instruction, local history.

  7. Silêncios Da Dor: Enfoque Geracional E Agência No Caso Do Desastre Radioativo De Goiânia, Brasil

    Directory of Open Access Journals (Sweden)

    Telma Camargo da Silva

    2017-01-01

    Full Text Available The text focuses on the Goiânia radiological disaster from the point of view of young people’s narratives, expressed in 2004, about their experiences as children back in 1987. The research draws on observations made in long term fieldwork with these young people as they hid their identities as disaster victims in the public sphere. Hence, in contexts in which the remembrances configure traumatic memory from this disaster and engender the 'cesium persona', I argue that their silence is a form of agency. I sustain as well that the understanding of the social and emotional impacts of a critical event implies taking into consideration the situation of social vulnerabilities of the people affected, including those which are produced over generations. Resumo Este texto focaliza o desastre radioativo de Goiânia, Brasil, a partir das narrativas enunciadas, em 2004, por jovens que vivenciaram a catástrofe, em 1987, enquanto crianças. A pesquisa foi motivada pela constatação, através do trabalho de campo realizado ao longo das últimas décadas, que estes jovens ocultavam no cenário público o pertencimento do desastre. Desta forma, em contexto em que as lembranças configuram a memória traumática e instituem uma 'persona césio', problematizo o silêncio como uma forma de agencia. Argumento também que a compreensão dos impactos sociais e emocionais de um evento crítico demanda uma reflexão sobre as situações de vulnerabilidade social dos grupos envolvidos entre as quais aquelas engendradas pela geração.

  8. Sonoro silêncio: por uma história etnográfica do aborto A resonant silence: for an ethnographic history of abortion

    Directory of Open Access Journals (Sweden)

    Flávia de Mattos Motta

    2008-08-01

    Full Text Available Usando métodos da História e da Antropologia, investigou-se a prática do aborto no Sul do Brasil na primeira metade do século XX. O exame de fontes primárias e as entrevistas com mulheres idosas visaram auscultar um enorme silêncio em torno dessa prática que deixa poucos vestígios em termos de fontes históricas e que reveste de segredos a memória. O texto apresenta dados registrados pela pesquisa e reflete sobre a diversidade das representações em torno do aborto, as ambigüidades dos sujeitos em relação ao tema. A prática do aborto precisa ser entendida como estando inserida num contexto de poder. Os sujeitos operam com conhecimentos de várias origens e dentro de uma rede moral composta de malhas contraditórias.By using methods of the fields of History and Anthropology, this study investigated the practice of abortion in southern Brazil in the first half of the twentieth century. The examination of primary sources and interviews with elderly women intended to unveil a huge silence around this practice, which leaves very few historical sources to be investigated, and hides those memories. This text presents data collected by this survey and analyzes the diversity of representations over abortion and the ambiguities that this theme causes on the subjects involved. The practice of abortion must be understood as inserted into a context of power. The subjects operate from multiple sources of knowledge and within a morality network composed of contradictory elements.

  9. Análise microscópica da resistência do arroz à queima das bainhas mediada pelo silício

    Directory of Open Access Journals (Sweden)

    Daniel Augusto Schurt

    2015-03-01

    Full Text Available A queima das bainhas, causada pelo fungo Rhizoctonia solani Kühn, é uma das mais importantes e destrutivas doenças que afetam a produção de arroz no mundo. Embora o silício (Si seja capaz de reduzir a intensidade da queima das bainhas, os mecanismos de resistência mediados por esse elemento permanecem desconhecidos. Assim, este trabalho teve como objetivo investigar a nível microscópico o efeito do Si na resistência do arroz à infecção por R. solani. Plantas de arroz das cultivares BR-Irga-409 e Labelle foram cultivadas em solução nutritiva contendo 0 ou 2 mM de Si e inoculadas no estádio de máximo perfilhamento utilizando-se pedaços de palito de dente colonizados por R. solani. Ambos cultivares supridas com Si apresentaram intensa e homogênea deposição de Si nos tecidos das bainhas colonizados por R. solani. A maior concentração de Si nas bainhas de plantas de arroz de ambas cultivares contribuiu para reduzir os sintomas da queima das bainhas. Com o auxílio da microscopia de luz e da microscopia eletrônica de varredura, observou-se menor crescimento micelial do fungo sobre as bainhas foliares das plantas de ambas cultivares que foram supridas com Si. Secções das bainhas de plantas de ambos cultivares supridas com Si exibiram intensa autofluorescência nos tecidos próximos a regiões necrosadas devido a colonização por R. solani. Em conclusão, o suprimento de Si às plantas de arroz desempenhou um papel importante na redução dos sintomas da queima das bainhas.

  10. Aspectos microscópicos da interação feijoeiro-Colletotrichum lindemuthianum mediados pelo silício

    Directory of Open Access Journals (Sweden)

    Maria Fernanda Antunes Cruz

    2014-09-01

    Full Text Available A antracnose, causada pelo fungo Colletotrichum lindemuthianum, é uma das doenças mais destrutivas que afetam a cultura do feijoeiro. Com o objetivo de encontrar alternativas para o controle dessa doença, o presente trabalho investigou, em nível microscópico, o efeito do silício (Si na resistência do feijoeiro à infecção por C. lindemuthianum. Plantas de feijoeiro (cv. Pérola foram cultivadas em solução nutritiva contendo 0 (-Si ou 2 mM (+Si de Si e inoculadas no estádio de crescimento V4 com uma suspensão de conídios de C. lindemuthianum. A severidade da antracnose decresceu cerca de 52% nas folhas das plantas supridas com Si (4,4% em relação às folhas das plantas não supridas (8,5%. Observações de folhas de feijoeiro das plantas não supridas com Si no microscópio eletrônico de varredura revelaram alterações morfológicas nas nervuras em contraste com as folhas de plantas supridas com Si. Utilizando-se a microanálise de raios-X, verificou-se maior concentração dos minerais enxofre, potássio e Si nas folhas das plantas supridas com Si. Em conclusão, o suprimento de Si em plantas de feijoeiro foi importante para reduzir os sintomas da antracnose.

  11. Dietary Flexibility Aids Asian Earthworm Invasion in North American Forests

    Science.gov (United States)

    On a local scale, invasiveness of introduced species and invasibility of habitats together determine invasion success. A key issue in invasion ecology has been how to quantify the contribution of species invasiveness and habitat invasibility separately. Conventional approaches, s...

  12. Sequence and organization of the rhoptry-associated-protein-1 (rap-1) locus for the sheep hemoprotozoan Babesia sp. BQ1 Lintan (B. motasi phylogenetic group).

    Science.gov (United States)

    Niu, Qingli; Bonsergent, Claire; Guan, Guiquan; Yin, Hong; Malandrin, Laurence

    2013-11-15

    Babesiosis is a frequent infection of animals worldwide by tick borne pathogen Babesia, and several species are responsible for ovine babesiosis. Recently, several Babesia motasi-like isolates were described in sheep in China. In this study, we sequenced the multigenic rap-1 gene locus of one of these isolates, Babesia sp. BQ1 Lintan. The RAP-1 proteins are involved in the process of red blood cells invasion and thus represent a potential target for vaccine development. A complex composition and organization of the rap-1 locus was discovered with: (1) the presence of 3 different types of rap-1 sequences (rap-1a, rap-1b and rap-1c); (2) the presence of multiple copies of rap-1a and rap-1b; (3) polymorphism among the rap-1a copies, with two classes (named rap-1a61 and rap-1a67) having a similarity of 95.7%, each class represented by two close variants; (4) polymorphism between rap-1a61-1 and rap-1a61-2 limited to three nucleotide positions; (5) a difference of eight nucleotides between rap-1a67-1 and rap-1a67-2 from position 1270 to the putative stop site of rap-1a67-1 which might produce two putative proteins of slightly different sizes; (6) the ratio of rap-1a copies corresponding to one rap-1a67, one rap-1a61-1 and one rap-1a61-2; (7) the presence of three different intergenic regions separating rap-1a, rap-1b and rap-1c; (8) interspacing of the rap-1a copies with rap-1b copies; and (9) the terminal position of rap-1c in the locus. A 31kb locus composed of 6 rap-1a sequences interspaced with 5 rap-1b sequences and with a terminal rap-1c copy was hypothesized. A strikingly similar sequence composition (rap-1a, rap-1b and rap-1c), as well as strong gene identities and similar locus organization with B. bigemina were found and highlight the conservation of synteny at this locus in this phylogenetic clade. Copyright © 2013 Elsevier B.V. All rights reserved.

  13. Klebsiella pneumoniae Invasive Syndrome

    Directory of Open Access Journals (Sweden)

    Vasco Evangelista

    2018-01-01

    Full Text Available Klebsiella pneumoniae invasive syndrome (KPIS is a rare clinical condition characterized by primary liver abscess associated with metastatic infection. Most case reports are from Southeast Asia, with only one case described in Portugal. The Authors present the case of a 44-year-old man with a history of fever, dry cough and cervicalgia. A thoracic computed tomography (CT scan showed multiple pulmonary and hepatic nodules, suggestive of metastatic malignancy. Both blood cultures and bronchoalveolar lavage were positive for Klebsiella pneumoniae. Imaging studies were repeated during his hospital stay, showing a reduction in both number and volume of identified lesions, thus revealing their infectious nature. This case illustrates how much this entity can mimic other illnesses.

  14. The construction of a normative scale of locus of control

    Directory of Open Access Journals (Sweden)

    Johann M. Schepers

    2005-10-01

    Full Text Available The primary objective of the study was to construct a normative scale of locus of control for use with students and adults. A corollary of the study was to establish the personality, interest and cognitive correlates of locus of control. Conceptually the instrument is based on attribution theory and on social learning theory. The first edition of the Locus of Control Inventory (LCI was applied to 356 first-year university students during 1994. A factor analysis of the 65 items of the inventory yielded three factors. The factors were interpreted as Autonomy, Internal Control and External Control. Three scales, corresponding to the three factors, were constructed, and yielded reliability coefficients of 0,80; 0,77 and 0,81 respectively. Following this the cognitive, interest and personality correlates of the LCI were determined. The implications of the findings are discussed. Opsomming Die hoofdoel van die studie was die konstruksie van ’n normatiewe skaal van lokus van beheer vir gebruik met studente en volwassenes. ’n Newe-doelwit van die studie was om die persoonlikheids-, belangstellings- en kognitiewe korrelate van lokus van beheer te bepaal. Konseptueel is die instrument op attribusieteorie en sosiale-leerteorie gebaseer. Die eerste-uitgawe van die Lokus van Beheervraelys (LvB is op 356 eerstejaaruniversiteitstudente toegepas gedurende 1994. ’n Faktorontleding van die 65 items van die vraelys is gedoen en het drie faktore opgelewer. Die faktore is as Outonomie, Interne Beheer en Eksterne Beheer geïnterpreteer. Voorts is drie skale wat ooreenstem met die drie faktore, gekonstrueer en het betroubaarhede van 0,80; 0,77 en 0,81, onderskeidelik, opgelewer. Vervolgens is die kognitiewe, belangstellings- en persoonlikheidskorrelate van die LvB bepaal. Die implikasies van die bevindinge word bespreek.

  15. Recent advances of flowering locus T gene in higher plants.

    Science.gov (United States)

    Xu, Feng; Rong, Xiaofeng; Huang, Xiaohua; Cheng, Shuiyuan

    2012-01-01

    Flowering Locus T (FT) can promote flowering in the plant photoperiod pathway and also facilitates vernalization flowering pathways and other ways to promote flowering. The expression of products of the FT gene is recognized as important parts of the flowering hormone and can induce flowering by long-distance transportation. In the present study, many FT-like genes were isolated, and the transgenic results show that FT gene can promote flowering in plants. This paper reviews the progress of the FT gene and its expression products to provide meaningful information for further studies of the functions of FT genes.

  16. Locus of the apices of projectile trajectories under constant drag

    Science.gov (United States)

    Hernández-Saldaña, H.

    2017-11-01

    Using the hodograph method, we present an analytical solution for projectile coplanar motion under constant drag, parametrised by the velocity angle. We find the locus formed by the apices of the projectile trajectories, and discuss its implementation for the motion of a particle on an inclined plane in presence of Coulomb friction. The range and time of flight are obtained numerically, and we find that the optimal launching angle is smaller than in the drag-free case. This is a good example of a problem with constant dissipation of energy that includes curvature; it is appropriate for intermediate courses of mechanics.

  17. Radiation-induced instability at the virescent locus in groundnut

    International Nuclear Information System (INIS)

    Patil, S.H.; Mouli Chandra

    1975-01-01

    A new case of instability induced in groundnut by γ-irradiation was classified as a variegated mutation according to its phenotypic expression. The mutant was isolated in M 2 generation and segregated for 50% virescents in subsequent generations. Studies on the phenotypic and genetic behaviour of the mutant suggested that (i) a mutation was induced v-locus and its unstable expression further mutated to a stable recessive condition, i.e., virescence, (ii) another mutation for gametophyte of Vsup(m) factor through the pollen, (iii) test crosses indicated that the variegation was controlled by a nuclear gene and not by plasmon. (author)

  18. Factor structure, reliability, and validity of the Levenson's Locus of Control Scale in Iranian infertile people.

    Science.gov (United States)

    Maroufizadeh, Saman; Omani Samani, Reza; Amini, Payam; Navid, Behnaz

    2016-09-01

    This study examined psychometric properties of the Levenson's Locus of Control Scale among Iranian infertile patients. In all, 312 infertile patients completed the Levenson's Locus of Control Scale and Hospital Anxiety and Depression Scale. The confirmatory factor analysis indicated that the original three-factor model of Levenson's Locus of Control Scale was adequate ( χ 2 / df = 2.139; goodness-of-fit index = 0.88; root mean square error of approximation = 0.061; and standardized root mean square residual = 0.076). The Cronbach's alpha of the subscales ranged from 0.56 to 0.67. The Levenson's Locus of Control Scale subscales significantly correlated with anxiety and depression, showing an acceptable convergent validity. In conclusion, the Levenson's Locus of Control Scale has adequate reliability and validity and can be used to measure locus of control orientation in Iranian infertile patients.

  19. Microbial ecology of biological invasions

    NARCIS (Netherlands)

    Putten, van der W.H.; Klironomos, J.N.; Wardle, D.A.

    2007-01-01

    Invasive microbes, plants and animals are a major threat to the composition and functioning of ecosystems; however, the mechanistic basis of why exotic species can be so abundant and disruptive is not well understood. Most studies have focused on invasive plants and animals, although few have

  20. Prioritizing invasive plant management strategies

    Science.gov (United States)

    Invasive plants are seriously impacting rangelands by displacing desirable species. Management of these species is expensive and careful allocation of scarce dollars is necessary. Ecologically-based invasive plant management (EBIPM) has the potential to provide an improved decision-making process ...

  1. Cell invasion through basement membrane

    Science.gov (United States)

    Morrissey, Meghan A; Hagedorn, Elliott J; Sherwood, David R

    2013-01-01

    Cell invasion through basement membrane is an essential part of normal development and physiology, and occurs during the pathological progression of human inflammatory diseases and cancer. F-actin-rich membrane protrusions, called invadopodia, have been hypothesized to be the “drill bits” of invasive cells, mediating invasion through the dense, highly cross-linked basement membrane matrix. Though studied in vitro for over 30 y, invadopodia function in vivo has remained elusive. We have recently discovered that invadopodia breach basement membrane during anchor cell invasion in C. elegans, a genetically and visually tractable in vivo invasion event. Further, we found that the netrin receptor DCC localizes to the initial site of basement membrane breach and directs invasion through a single gap in the matrix. In this commentary, we examine how the dynamics and structure of AC-invadopodia compare with in vitro invadopodia and how the netrin receptor guides invasion through a single basement membrane breach. We end with a discussion of our surprising result that the anchor cell pushes the basement membrane aside, instead of completely dissolving it through proteolysis, and provide some ideas for how proteases and physical displacement may work together to ensure efficient and robust invasion. PMID:24778942

  2. Interstitial guidance of cancer invasion.

    NARCIS (Netherlands)

    Gritsenko, P.G.; Ilina, O.; Friedl, P.H.

    2012-01-01

    Cancer cell invasion into healthy tissues develops preferentially along pre-existing tracks of least resistance, followed by secondary tissue remodelling and destruction. The tissue scaffolds supporting or preventing guidance of invasion vary in structure and molecular composition between organs. In

  3. Earthworm invasions in the tropics

    Science.gov (United States)

    Grizelle Gonzalez; Ching Yu Huang; Xiaoming Zou; Carlos Rodriguez

    2006-01-01

    The effects and implications of invasive species in belowground terrestrial ecosystems are not well known in comparison with aboveground terrestrial and marine environments. The study of earthworm invasions in the tropics is limited by a lack of taxonomic knowledge and the potential for loss of species in native habitats due to anthropogenic land use change. Alteration...

  4. Invasive tightly coupled processor arrays

    CERN Document Server

    LARI, VAHID

    2016-01-01

    This book introduces new massively parallel computer (MPSoC) architectures called invasive tightly coupled processor arrays. It proposes strategies, architecture designs, and programming interfaces for invasive TCPAs that allow invading and subsequently executing loop programs with strict requirements or guarantees of non-functional execution qualities such as performance, power consumption, and reliability. For the first time, such a configurable processor array architecture consisting of locally interconnected VLIW processing elements can be claimed by programs, either in full or in part, using the principle of invasive computing. Invasive TCPAs provide unprecedented energy efficiency for the parallel execution of nested loop programs by avoiding any global memory access such as GPUs and may even support loops with complex dependencies such as loop-carried dependencies that are not amenable to parallel execution on GPUs. For this purpose, the book proposes different invasion strategies for claiming a desire...

  5. Locus de control y conocimiento, actitud y práctica contraceptivas entre adolescentes universitarios

    OpenAIRE

    Alves, Aline Salheb; Lopes, Maria Helena Baena de Moraes

    2010-01-01

    OBJECTIVE: To assess the relationship between locus of control and knowledge, attitude and practice regarding pill and condom use among university students. METHODS: The inquiry was developed in Campinas, a city in Southeastern Brazil, in 2006. A total of 295 adolescent newcomers to a public university answered a structured questionnaire and Levenson's multidimensional locus of control scale. The scores of the dimensions of locus of control were calculated and Spearman's correlation coefficie...

  6. Characterization of additional rabbit IgM allotypes and the effect of suppression of a VH locus allotypes on the expression of n Cμ locus allotype

    International Nuclear Information System (INIS)

    Gilman-Sachs, A.; Roux, K.H.; Horing, W.J.; Dray, S.

    1982-01-01

    Anti-allotype antisera were produced that identified eight rabbit IgM allotypic specificities, n80, n81, n82, n83, n84, n85, n86, and n87. The n locus Cμ genes controlling these IgM allotypic specificities are closely linked to the a (VH subgroup) locus. The genes controlling these allotypic specificities were found to be in the heavy chain chromosomal region and were assigned to 11 haplotypes present in our rabbit colony. The n locus and a locus genes appeared in the haplotypes in six combinations: a 1 n 81 , a 2 n/sup 81,n87/, a 1 n/sup 80,83/, a 2 n/sup 80,82,87/, a 3 n/sup 81,84,85/ and a 3 n/sup 80,84,86,87/. By radioprecipitation analysis, 70 to 80% of serum IgM reacts with the antiserum directed to each n locus allotypic specificity found encoded in one haplotype; thus, each allotypic specificity of the haplotype is present on the same IgM molecule. When sera from a locus allotype-suppressed homozygous rabbits were tested for expression of each n locus allotypic specificity, n80, n81, and n87 were still expressed, whereas n82, n83, n84, n85, and n86 were not. These data provide direct evidence that some IgM specificities are expressed independently of the a locus (i.e., ''true''), and other s are dependent on the expression of an a locus specificity (i.e., conformational). The expression of the ''true'' allotypic specificities probably reflects genetic control of the germline Cμ gene, and the expression of ''conformationally dependent'' allotypic specificities probably reflects the interaction of VH and Cμ gene segments. This distinction is important and must be recognized when evaluating the genetics and structure of the IgM molecule

  7. Long-Distance Control of Origin Choice and Replication Timing in the Human β-Globin Locus Are Independent of the Locus Control Region

    Science.gov (United States)

    Cimbora, Daniel M.; Schübeler, Dirk; Reik, Andreas; Hamilton, Joan; Francastel, Claire; Epner, Elliot M.; Groudine, Mark

    2000-01-01

    DNA replication in the human β-globin locus is subject to long-distance regulation. In murine and human erythroid cells, the human locus replicates in early S phase from a bidirectional origin located near the β-globin gene. This Hispanic thalassemia deletion removes regulatory sequences located over 52 kb from the origin, resulting in replication of the locus from a different origin, a shift in replication timing to late S phase, adoption of a closed chromatin conformation, and silencing of globin gene expression in murine erythroid cells. The sequences deleted include nuclease-hypersensitive sites 2 to 5 (5′HS2-5) of the locus control region (LCR) plus an additional 27-kb upstream region. We tested a targeted deletion of 5′HS2-5 in the normal chromosomal context of the human β-globin locus to determine the role of these elements in replication origin choice and replication timing. We demonstrate that the 5′HS2-5-deleted locus initiates replication at the appropriate origin and with normal timing in murine erythroid cells, and therefore we conclude that 5′HS2-5 in the classically defined LCR do not control replication in the human β-globin locus. Recent studies also show that targeted deletion of 5′HS2-5 results in a locus that lacks globin gene expression yet retains an open chromatin conformation. Thus, the replication timing of the locus is closely correlated with nuclease sensitivity but not globin gene expression. PMID:10891496

  8. External locus of control contributes to racial disparities in memory and reasoning training gains in ACTIVE.

    Science.gov (United States)

    Zahodne, Laura B; Meyer, Oanh L; Choi, Eunhee; Thomas, Michael L; Willis, Sherry L; Marsiske, Michael; Gross, Alden L; Rebok, George W; Parisi, Jeanine M

    2015-09-01

    Racial disparities in cognitive outcomes may be partly explained by differences in locus of control. African Americans report more external locus of control than non-Hispanic Whites, and external locus of control is associated with poorer health and cognition. The aims of this study were to compare cognitive training gains between African American and non-Hispanic White participants in the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) study and determine whether racial differences in training gains are mediated by locus of control. The sample comprised 2,062 (26% African American) adults aged 65 and older who participated in memory, reasoning, or speed training. Latent growth curve models evaluated predictors of 10-year cognitive trajectories separately by training group. Multiple group modeling examined associations between training gains and locus of control across racial groups. Compared to non-Hispanic Whites, African Americans evidenced less improvement in memory and reasoning performance after training. These effects were partially mediated by locus of control, controlling for age, sex, education, health, depression, testing site, and initial cognitive ability. African Americans reported more external locus of control, which was associated with smaller training gains. External locus of control also had a stronger negative association with reasoning training gain for African Americans than for Whites. No racial difference in training gain was identified for speed training. Future intervention research with African Americans should test whether explicitly targeting external locus of control leads to greater cognitive improvement following cognitive training. (c) 2015 APA, all rights reserved).

  9. [Locus of control in girls with anorexia readiness syndrome].

    Science.gov (United States)

    Jaros, Katarzyna; Oszwa, Urszula

    2014-01-01

    The aim of the research was to indicate whether there are differences between locus of control (LOC) in girls with anorexia readiness syndrome (ARS) and without this syndrome. There was also a question about the relationship between LOC and the tendency to respond in incorrect attitudes towards food, eating and their bodies under stress. The sample consisted of girls aged 13-18 years randomly selected from five public Polish middle and high schools. Tools: 1) Eating Attitudes Questionnaire (EAQ) by B. Ziółkowska; 2) Locus of Control Questionnaire (LOCQ) by G. Krasowicz, A. Kurzyp-Wojnarska, to assess LOC of the subjects. The criterion group (N=23) was formed by girls who received high score in EAQ (signs of ARS) in the first stage of research (N=189). The control group (N = 23) were girls who received a low score in EAQ (no signs of ARS). Subjects with ARS were characterized by more external LOC than girls without any signs of this syndrome (t = -2.898; p control, LOC may play a role as a mediating variable rather than a direct determinant of this syndrome.

  10. Breaking bad news: patients' preferences and health locus of control.

    Science.gov (United States)

    Martins, Raquel Gomes; Carvalho, Irene Palmares

    2013-07-01

    To identify patients' preferences for models of communicating bad news and to explore how such preferences, and the reasons for the preferences, relate with personality characteristics, specifically patients' health locus of control (HLC): internal/external and 'powerful others' (PO). Seventy-two patients from an oncology clinic watched videotaped scenarios of a breaking bad news moment, selected the model they preferred, filled an HLC scale and were interviewed about their choices. Data were analyzed with Chi-square, Kruskal-Wallis and Mann-Whitney tests. Interviews were content-analyzed. 77.8% preferred an "empathic professional", 12.5% a "distanced expert" and 9.7% an "emotionally burdened expert". Preferences varied significantly with HLC scores (patients with higher internal locus of control (ILC) and lower PO preferred the empathic model), presence of cancer, age and education. Patients explained their preferences through aspects of Caring, Professionalism, Wording, Time and Hope. ILC registered significant differences in regards to Wording and Time, whereas PO was associated with Hope and Time. HLC is an important dimension that can help doctors to better know their patients. Knowing whether patients attribute their health to their own behaviors or to chance/others can help tailor the disclosure of bad news to their specific preferences. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  11. Allelism of Genes in the Ml-a locus

    DEFF Research Database (Denmark)

    Giese, Nanna Henriette; Jensen, Hans Peter; Jørgensen, Jørgen Helms

    1980-01-01

    Seven barley lines or varieties, each with a different gene at the Ml-a locus for resistance to Erysiphe graminis were intercrossed. Progeny testing of the F2s using two different fungal isolates per cross provided evidence that there are two or more loci in the Ml-a region. Apparent recombinants...... were also screened for recombination between the Hor1 and Hor2 loci which are situated either side of the Ml-a locus. The cross between Ricardo and Iso42R (Rupee) yielded one possible recombinant, with Ml-a3 and Ml-a(Rul) in the coupling phase; other recombinants had wild-type genes in the coupling...... phase. Iso20R, derived from Hordeum spontaneum 'H204', carrying Ml-a6, had an additional gene, in close coupling with Ml-a6, tentatively named Ml-aSp2 or Reglv, causing an intermediate infection type with isolate EmA30. It is suggested that Ml-a(Ar) in Emir and Ml-a(Rul), shown to differ from other Ml...

  12. LOCUS: immunizing medical students against the loss of professional values.

    Science.gov (United States)

    Carufel-Wert, Donald A; Younkin, Sharon; Foertsch, Julie; Eisenberg, Todd; Haq, Cynthia L; Crouse, Byron J; Frey Iii, John J

    2007-05-01

    The Leadership Opportunities with Communities, the Underserved, and Special populations (LOCUS) program at the University of Wisconsin School of Medicine and Public Health is a longitudinal, extracurricular experience for medical students who wish to develop leadership skills and expand their involvement in community health activities during medical school. The program consists of a core curriculum delivered through retreats, workshops, and seminars; a mentor relationship with a physician who is engaged in community health services; and a community service project. On-line surveys and interviews with current and past participants as well as direct observations were used to evaluate the effects of the program on participants. Participants indicated that the program was worthwhile, relevant, and effective in building a community of like-minded peers and physician role models. Participants also reported that the program sustained their interest in and commitment to community service and allowed them to cultivate new skills during medical school. The curriculum and structure of the LOCUS program offers a successful method for helping medical students learn important leadership skills and maintain an altruistic commitment to service.

  13. Attenuation measurements show that the presence of a TachoSil surgical patch will not compromise target irradiation in intra-operative electron radiation therapy or high-dose-rate brachytherapy.

    Science.gov (United States)

    Sarmento, Sandra; Costa, Filipa; Pereira, Alexandre; Lencart, Joana; Dias, Anabela; Cunha, Luís; Sousa, Olga; Silva, José Pedro; Santos, Lúcio

    2015-01-09

    Surgery of locally advanced and/or recurrent rectal cancer can be complemented with intra-operative electron radiation therapy (IOERT) to deliver a single dose of radiation directly to the unresectable margins, while sparing nearby sensitive organs/structures. Haemorrhages may occur and can affect the dose distribution, leading to an incorrect target irradiation. The TachoSil (TS) surgical patch, when activated, creates a fibrin clot at the surgical site to achieve haemostasis. The aim of this work was to determine the effect of TS on the dose distribution, and ascertain whether it could be used in combination with IOERT. This characterization was extended to include high dose rate (HDR) intraoperative brachytherapy, which is sometimes used at other institutions instead of IOERT. CT images of the TS patch were acquired for initial characterization. Dosimetric measurements were performed in a water tank phantom, using a conventional LINAC with a hard-docking system of cylindrical applicators. Percentage Depth Dose (PDD) curves were obtained, and measurements made at the depth of dose maximum for the three clinically used electron energies (6, 9 and 12MeV), first without any attenuator and then with the activated patch of TS completely covering the tip of the IOERT applicator. For HDR brachytherapy, a measurement setup was improvised using a solid water phantom and a Farmer ionization chamber. Our measurements show that the attenuation of a TachoSil patch is negligible, both for high energy electron beams (6 to 12MeV), and for a HDR (192)Ir brachytherapy source. Our results cannot be extrapolated to lower beam energies such as 50 kVp X-rays, which are sometimes used for breast IORT. The TachoSil surgical patch can be used in IORT procedures using 6MeV electron energies or higher, or HDR (192)Ir brachytherapy.

  14. The Gene tia, Harbored by the Subtilase-Encoding Pathogenicity Island, Is Involved in the Ability of Locus of Enterocyte Effacement-Negative Shiga Toxin-Producing Escherichia coli Strains To Invade Monolayers of Epithelial Cells.

    Science.gov (United States)

    Bondì, Roslen; Chiani, Paola; Michelacci, Valeria; Minelli, Fabio; Caprioli, Alfredo; Morabito, Stefano

    2017-12-01

    Locus of enterocyte effacement (LEE)-negative Shiga toxin (Stx)-producing Escherichia coli (STEC) strains are human pathogens that lack the LEE locus, a pathogenicity island (PAI) involved in the intimate adhesion of LEE-positive strains to the host gut epithelium. The mechanism used by LEE-negative STEC strains to colonize the host intestinal mucosa is still not clear. The cell invasion determinant tia , previously described in enterotoxigenic E. coli strains, has been identified in LEE-negative STEC strains that possess the subtilase-encoding pathogenicity island (SE-PAI). We evaluated the role of the gene tia , present in these LEE-negative STEC strains, in the invasion of monolayers of cultured cells. We observed that these strains were able to invade Caco-2 and HEp-2 cell monolayers and compared their invasion ability with that of a mutant strain in which the gene tia had been inactivated. Mutation of the gene tia resulted in a strong reduction of the invasive phenotype, and complementation of the tia mutation with a functional copy of the gene restored the invasion activity. Moreover, we show that the gene tia is overexpressed in bacteria actively invading cell monolayers, demonstrating that tia is involved in the ability to invade cultured monolayers of epithelial cells shown by SE-PAI-positive E. coli , including STEC, strains. However, the expression of the tia gene in the E. coli K-12 strain JM109 was not sufficient, in its own right, to confer to this strain the ability to invade cell monolayers, suggesting that at least another factor must be involved in the invasion ability displayed by the SE-PAI-positive strains. Copyright © 2017 American Society for Microbiology.

  15. Superdiffusion of Carbon by Vacancies Irradiated with Soft X-Rays in CZ Silicon / Superdifūzija Ar Vakancēm Iestarota Ar Mīkstajiem Rentgenstariem CZ Silīcijā

    Science.gov (United States)

    Janavičius, A. J.; Mekys, A.; Purlys, R.; Norgėla, Ž.; Daugėla, S.; Rinkūnas, R.

    2015-10-01

    The soft X-ray photons absorbed in the inner K, L, M shells of Si atoms produce photoelectrons and Auger electrons, thus generating vacancies, interstitials and metastable oxygen complexes. The samples of Czochralski silicon crystals covered with 0.1 μm thickness layer of carbon have been irradiated by X-rays using different voltages of Cu anode of the Russian diffractometer DRON-3M. The influence of X-rays on the formation of point defects and vacancy complexes, and their dynamics in Cz-Si crystals have been studied by infrared absorption. We have measured and calculated dynamics of concentration of carbon and interstitial oxygen using FTIR spectroscopy at room temperature after irradiation by soft X-rays. Using transmittance measurements and nonlinear diffusion theory we have calculated densities increasing for substitutional carbon and interstitial oxygen by reactions and very fast diffusion. The superdiffusion coefficients of carbon in silicon at room temperature generated by X-rays are about hundred thousand times greater than diffusion coefficients obtained for thermodiffusion. Rezumējums: Rentgena staru fotoni, absorbēti Si atoma iekšējos slāņos, izstaro fotoelektronus un Ožē elektronus, ģenerējot vakances, starpmezglu silīcija atomus, vakanču un skābekļa kompleksus. Čohraļska silīcija kristāli, kas pārklāti ar oglekli 0.1 μm biezuma kārtā, tika apstaroti ar rentgena stariem, izmantojot krievu difraktometru DRON-3M. Oglekļa un skābekļa difūzija un koncentrāciju izmaiņa silīcijā tika izmērīta izmantojot infrasarkano staru FTIR spektroskopiju. Rentgena staru ģenerētās ļoti ātrās oglekļa difūzijas vai superdifūzijas koeficients istabas temperatūrā silīcijā ir simtiem tūkstošu reižu lielāks nekā termodifūzijas gadījumā.

  16. Efeito do silício e do fósforo na disponibilidade de metais pesados do solo pelo extrator mehlich-1 Effect of silicon and phosphorus on the availability of soil heavy metals by mehlich-1 extractor

    Directory of Open Access Journals (Sweden)

    Lilian Aparecida Paim

    2003-08-01

    Full Text Available Este trabalho foi desenvolvido em um solo contaminado por metais pesados de uma área de extração e industrialização de zinco pertencente à Companhia Mineira de Metais, em Três Marias, MG, com o objetivo de avaliar a eficiência do silício e do fósforo como agentes amenizadores da toxidez dos metais pesados. As amostras coletadas foram preparadas e incubadas em frascos de polietileno, com umidade equivalente a 60% do volume total de poros. Foram utilizados 25 tratamentos: cinco doses de silício (0; 2.340; 6.040; 9.860 e 13.660 mg dm-3 e cinco de fósforo (0; 90; 180; 360 e 720 mg dm-3, com quatro repetições, totalizando 100 unidades experimentais. Aos 30 e 60 dias, coletaram-se amostras de cada tratamento, submetidas a análises de pH em água e extrações simples por Mehlich-1. Os teores extraídos receberam influência do silício, do fósforo e do pH. Os teores de Zn e Cd, embora reduzidos, permaneceram acima dos níveis permitidos. O Pb diminuiu influenciado pelo incremento de silício e fósforo a níveis inferiores aos permitidos.This work was developed on a soil contaminated by heavy metals from a zinc-extracting and industrializing area belonging to the Companhia Mineira de Metais at Tres Marias, Minas Gerais state, Brazil, with a view to evaluating the efficiency of silicon and phosphorus as ameliorating agents of heavy metal toxicity. The samples collected were prepared and incubated into polyethylene flasks, moisture equivalent to 60% of the total volume of pores. 25 treatments were utilized: five doses of silicon (0; 2.340; 6.040; 9.860 and 13.660 mg dm-3 and five of phosphorus (0; 90; 180; 360 and 720 mg dm-3 with four replicates amounting to 100 experimental units. At 30 and 60 days, samples from each treatment were collected, submitted to water pH analysis and simple extraction by Mehlich-1. The extracted contents received greater influence from both silicon and phosphorous and at a lesser extent from pH. Zn and Cd

  17. Implementación de un Portal Web de Oferta Laboral Utilizando Cms Joomla y Google Analytics, para el SIL – Servicio de Integración Laboral de Personas con Discapacidad en la Ciudad de Guayaquil

    OpenAIRE

    Medrano Elao, Karina Elizabeth; Trujillo Matovelle, Ana Rosario

    2015-01-01

    El presente proyecto tiene como objetivo implementar un Portal Web de oferta laboral para el SIL – Servicio de Integración Laboral para personas con discapacidad, desarrollado bajo la plataforma Joomla, un Sistema de Gestor de Contenido (CMS), con este portal se desea ayudar a que las personas con discapacidad tengan la facilidad para acceder a búsquedas de plazas de trabajos. Este Portal Web brindará información a los usuarios sobre los cursos de formación básica pre profesional, charlas,...

  18. Rapid Microsatellite Marker Development Using Next Generation Pyrosequencing to Inform Invasive Burmese Python—Python molurus bivittatus—Management

    Directory of Open Access Journals (Sweden)

    Kristen M. Hart

    2013-02-01

    Full Text Available Invasive species represent an increasing threat to native ecosystems, harming indigenous taxa through predation, habitat modification, cross-species hybridization and alteration of ecosystem processes. Additionally, high economic costs are associated with environmental damage, restoration and control measures. The Burmese python, Python molurus bivittatus, is one of the most notable invasive species in the US, due to the threat it poses to imperiled species and the Greater Everglades ecosystem. To address population structure and relatedness, next generation sequencing was used to rapidly produce species-specific microsatellite loci. The Roche 454 GS-FLX Titanium platform provided 6616 di-, tri- and tetra-nucleotide repeats in 117,516 sequences. Using stringent criteria, 24 of 26 selected tri- and tetra-nucleotide loci were polymerase chain reaction (PCR amplified and 18 were polymorphic. An additional six cross-species loci were amplified, and the resulting 24 loci were incorporated into eight PCR multiplexes. Multi-locus genotypes yielded an average of 61% (39%–77% heterozygosity and 3.7 (2–6 alleles per locus. Population-level studies using the developed microsatellites will track the invasion front and monitor population-suppression dynamics. Additionally, cross-species amplification was detected in the invasive Ball, P. regius, and Northern African python, P. sebae. These markers can be used to address the hybridization potential of Burmese pythons and the larger, more aggressive P. sebae.

  19. Rapid microsatellite marker development using next generation pyrosequencing to inform invasive Burmese python -- Python molurus bivittatus -- management

    Science.gov (United States)

    Hunter, Margaret E.; Hart, Kristen M.

    2013-01-01

    Invasive species represent an increasing threat to native ecosystems, harming indigenous taxa through predation, habitat modification, cross-species hybridization and alteration of ecosystem processes. Additionally, high economic costs are associated with environmental damage, restoration and control measures. The Burmese python, Python molurus bivittatus, is one of the most notable invasive species in the US, due to the threat it poses to imperiled species and the Greater Everglades ecosystem. To address population structure and relatedness, next generation sequencing was used to rapidly produce species-specific microsatellite loci. The Roche 454 GS-FLX Titanium platform provided 6616 di-, tri- and tetra-nucleotide repeats in 117,516 sequences. Using stringent criteria, 24 of 26 selected tri- and tetra-nucleotide loci were polymerase chain reaction (PCR) amplified and 18 were polymorphic. An additional six cross-species loci were amplified, and the resulting 24 loci were incorporated into eight PCR multiplexes. Multi-locus genotypes yielded an average of 61% (39%–77%) heterozygosity and 3.7 (2–6) alleles per locus. Population-level studies using the developed microsatellites will track the invasion front and monitor population-suppression dynamics. Additionally, cross-species amplification was detected in the invasive Ball, P. regius, and Northern African python, P. sebae. These markers can be used to address the hybridization potential of Burmese pythons and the larger, more aggressive P. sebae.

  20. Port insertion for minimally invasive surgery: a report of practices in the Irish Republic.

    Science.gov (United States)

    Harrington, Cuan M; Kavanagh, Dara O; Tierney, Sean; Deane, Richard; Hehir, Dermot

    2018-02-06

    With rapidly evolving surgical technologies, minimally invasive surgery (MIS) has become the mainstay approach for many surgeons worldwide. As laparoscopic surgery was introduced in Ireland over two decades ago, we may be encountering a higher prevalence of related complications. This study aimed to gather data pertaining to risk factors for port-site herniation in MIS. A 14-point anonymous questionnaire was distributed electronically between January and May 2017 to consultant and trainee laparoscopists in the Republic of Ireland. This survey related to laparoscopic volume and surgical approaches to laparoscopic port-sites. There were 172 eligible responses nationally. Approaches to peritoneal access included Hasson, veress (blind puncture) and SILS were 66.3, 32.6 and 1.2%, respectively. Senior surgeons and specialists in Obstetrics and Gynaecology (OBGYN) reported significantly higher utilisations of closed peritoneal access (p ports using absorbable suture in 76.7%, non-absorbable suture in 14.5% and port closure devices in 8.7%. Perceptions of risk factors for PSH were not congruent with significant variations in responses between levels of expertise. This study demonstrates significant variations in laparoscopic port-site practices amongst surgeons nationally. The new era of practitioners may benefit from evidence-based technical workshops and guidelines to increase awareness and reduce potential complications.

  1. Invasive meningococcal disease

    Directory of Open Access Journals (Sweden)

    Vanessa L. Strelow

    2013-09-01

    Full Text Available Invasive meningococcal disease (IMD is a major public health and continues to cause substantial mortality and morbidity. Serotype C is the most frequent in Brazil. The clinical spectrum of IMD is broad (meningitis, meningococcemia or both and the clinical evolution may be unpredictable. Main features associated with mortality are: age higher than 50 years old, seizures, shock, and meningococcemia without meningitis. Blood cultures should be obtained immediately. Lumbar puncture can be performed without previous computed tomography scan (CT in most cases. Clinical features can be useful to predic patients where an abnormal CT scan is likely. Cerebrospinal fluid (CSF culture and Gram stain should always be required. Latex agglutination sensitivity is highly variable. Polymerase chain reaction is specially useful when other methods are negative or delayed. Usually ceftriaxone should not be delayed while awaiting CSF study or CT. Dexamethasone can be used in meningococcal meningitis. Early suspicion of IMD and antibiotic in primary care before hospitalization, rapid transportation to a hospital, and stabilization in an intensive-care unit has substantially reduced the case-fatality rate. Vaccines against serotypes A, C, W-135, and Y are available while vaccines against serotype B are expected.

  2. Non-invasive hemoglobin monitoring.

    Science.gov (United States)

    Joseph, Bellal; Haider, Ansab; Rhee, Peter

    2016-09-01

    Technology has transformed the practice of medicine and surgery in particular over the last several decades. This change in practice has allowed diagnostic and therapeutic tests to be performed less invasively. Hemoglobin monitoring remains one of the most commonly performed diagnostic tests in the United States. Recently, non-invasive hemoglobin monitoring technology has gained popularity. The aim of this article is to review the principles of how this technology works, pros and cons, and the implications of non-invasive hemoglobin technology particularly in trauma surgery. Copyright © 2015 IJS Publishing Group Ltd. Published by Elsevier Ltd. All rights reserved.

  3. Are there gender differences in locus of control specific to alcohol dependence?

    Science.gov (United States)

    McPherson, Andrew; Martin, Colin R

    2017-01-01

    To investigate gender differences in locus of control in an alcohol-dependent population. Locus of control helps to explain behaviour in terms of internal (the individual is responsible) or external (outside forces, such as significant other people or chance, are responsible) elements. Past research on gender differences in locus of control in relation to alcohol dependence has shown mixed results. There is a need then to examine gender and locus of control in relation to alcohol dependence to ascertain the veracity of any locus of control differences as a function of gender. The Multidimensional Health Locus of Control form-C was administered to clients from alcohol dependence treatment centres in the West of Scotland. Independent t-tests were carried out to assess gender differences in alcohol dependence severity and internal/external aspects of locus of control. One hundred and eighty-eight (53% females) participants were recruited from a variety of alcohol dependence treatment centres. The majority of participants (72%) came from Alcoholics Anonymous groups. Women revealed a greater internal locus of control compared with men. Women also had a greater 'significant others' locus of control score than men. Men were more reliant on 'chance' and 'doctors' than women. All these trends were not, however, statistically significant. Gender differences in relation to locus of control and alcohol dependence from past studies are ambiguous. This study also found no clear statistically significant differences in locus of control orientation as a function of gender. This article helps nurses to contextualise health behaviours as a result of internal or external forces. It also helps nursing staff to better understand alcohol dependence treatment in relation to self-efficacy and control. Moreover, it highlights an important concept in health education theory. © 2016 John Wiley & Sons Ltd.

  4. Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited

    DEFF Research Database (Denmark)

    Deelen, Joris; Beekman, Marian; Uh, Hae-Won

    2011-01-01

    (LLS) and 1670 younger population controls. The strongest candidate SNPs from this GWAS have been analyzed in a meta-analysis of nonagenarian cases from the Rotterdam Study, Leiden 85-plus study and Danish 1905 cohort. Only one of the 62 prioritized SNPs from the GWAS analysis (P ... genome-wide significance with survival into old age in the meta-analysis of 4149 nonagenarian cases and 7582 younger controls (OR = 0.71 (95% CI 0.65-0.77), P = 3.39 x 10(-17) ). This SNP, rs2075650, is located in TOMM40 at chromosome 19q13.32 close to the apolipoprotein E (APOE) gene. Although...... of the nonagenarian cases from the LLS and their partners. In addition, we observed a novel association between this locus and serum levels of IGF-1 in females (P = 0.005). In conclusion, the major locus determining familial longevity up to high age as detected by GWAS was marked by rs2075650, which tags...

  5. Del-1 overexpression potentiates lung cancer cell proliferation and invasion

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Seung-Hwan; Kim, Dong-Young; Jing, Feifeng; Kim, Hyesoon [Department of Biomedical Sciences, University of Ulsan College of Medicine, Seoul (Korea, Republic of); Yun, Chae-Ok [Department of Bioengineering, College of Engineering, Hanyang University, Seoul (Korea, Republic of); Han, Deok-Jong [Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of); Choi, Eun Young, E-mail: choieun@ulsan.ac.kr [Department of Biomedical Sciences, University of Ulsan College of Medicine, Seoul (Korea, Republic of)

    2015-12-04

    Developmental endothelial locus-1 (Del-1) is an endogenous anti-inflammatory molecule that is highly expressed in the lung and the brain and limits leukocyte migration to these tissues. We previously reported that the expression of Del-1 is positively regulated by p53 in lung endothelial cells. Although several reports have implicated the altered expression of Del-1 gene in cancer patients, little is known about its role in tumor cells. We here investigated the effect of Del-1 on the features of human lung carcinoma cells. Del-1 mRNA was found to be significantly decreased in the human lung adenocarcinoma cell lines A549 (containing wild type of p53), H1299 (null for p53) and EKVX (mutant p53), compared to in human normal lung epithelial BEAS-2B cells and MRC-5 fibroblasts. The decrease of Del-1 expression was dependent on the p53 activity in the cell lines, but not on the expression of p53. Neither treatment with recombinant human Del-1 protein nor the introduction of adenovirus expressing Del-1 altered the expression of the apoptosis regulators BAX, PUMA and Bcl-2. Unexpectedly, the adenovirus-mediated overexpression of Del-1 gene into the lung carcinoma cell lines promoted proliferation and invasion of the lung carcinoma cells, as revealed by BrdU incorporation and transwell invasion assays, respectively. In addition, overexpression of the Del-1 gene enhanced features of epithelial–mesenchymal transition (EMT), such as increasing vimentin while decreasing E-cadherin in A549 cells, and increases in the level of Slug, an EMT-associated transcription regulator. Our findings demonstrated for the first time that there are deleterious effects of high levels of Del-1 in lung carcinoma cells, and suggest that Del-1 may be used as a diagnostic or prognostic marker for cancer progression, and as a novel therapeutic target for lung carcinoma. - Highlights: • Developmental Endothelial Locus-1 (Del-1) expression is downregulated in human lung cancer cells.

  6. Del-1 overexpression potentiates lung cancer cell proliferation and invasion

    International Nuclear Information System (INIS)

    Lee, Seung-Hwan; Kim, Dong-Young; Jing, Feifeng; Kim, Hyesoon; Yun, Chae-Ok; Han, Deok-Jong; Choi, Eun Young

    2015-01-01

    Developmental endothelial locus-1 (Del-1) is an endogenous anti-inflammatory molecule that is highly expressed in the lung and the brain and limits leukocyte migration to these tissues. We previously reported that the expression of Del-1 is positively regulated by p53 in lung endothelial cells. Although several reports have implicated the altered expression of Del-1 gene in cancer patients, little is known about its role in tumor cells. We here investigated the effect of Del-1 on the features of human lung carcinoma cells. Del-1 mRNA was found to be significantly decreased in the human lung adenocarcinoma cell lines A549 (containing wild type of p53), H1299 (null for p53) and EKVX (mutant p53), compared to in human normal lung epithelial BEAS-2B cells and MRC-5 fibroblasts. The decrease of Del-1 expression was dependent on the p53 activity in the cell lines, but not on the expression of p53. Neither treatment with recombinant human Del-1 protein nor the introduction of adenovirus expressing Del-1 altered the expression of the apoptosis regulators BAX, PUMA and Bcl-2. Unexpectedly, the adenovirus-mediated overexpression of Del-1 gene into the lung carcinoma cell lines promoted proliferation and invasion of the lung carcinoma cells, as revealed by BrdU incorporation and transwell invasion assays, respectively. In addition, overexpression of the Del-1 gene enhanced features of epithelial–mesenchymal transition (EMT), such as increasing vimentin while decreasing E-cadherin in A549 cells, and increases in the level of Slug, an EMT-associated transcription regulator. Our findings demonstrated for the first time that there are deleterious effects of high levels of Del-1 in lung carcinoma cells, and suggest that Del-1 may be used as a diagnostic or prognostic marker for cancer progression, and as a novel therapeutic target for lung carcinoma. - Highlights: • Developmental Endothelial Locus-1 (Del-1) expression is downregulated in human lung cancer cells.

  7. Estado del conocimiento de la durofagia en el registro fósil: interacción depredador-presa en moluscos marinos (Clases Gastropoda y Bivalvia

    Directory of Open Access Journals (Sweden)

    Catalina Gómez-Espinosa

    2015-01-01

    Full Text Available La depredación como un mecanismo evolutivo, de diversificación y biomineralización es un tópico de gran interés. Un tipo específico de depredación es la durofagia que se define como el hábito alimenticio de los animales que consumen organismos con un esqueleto duro mineralizado, ya sea concha o exoesqueleto. Los moluscos representan una fuente muy importante para examinar la depredación durófaga en el registro fósil debido a su distribución mundial, abundancia, buena preservación y a que habitan en una gran variedad de ambientes. En este trabajo se revisa el número de artículos publicados en revistas de circulación internacional que se enfocan en el tema de la durofagia y que tienen como potenciales presas a gasterópodos y bivalvos marinos fósiles. Se recuperaron y revisaron 101 artículos sobre este tema, enfocados en seis tipos de evidencia: perforación, reparación y fragmentación de la concha, mordidas, “punctures” y coprolitos. La mayoría de los ejemplos correspondieron a moluscos del Cenozoico. En general hay más registros en la zona tropical. Durante el Paleozoico, la mayoría de las veces, no se identificó el potencial depredador; esta tendencia continuó en el Mesozoico pero se reconoció la depredación de gasterópodos y bivalvos por parte de gasterópodos carnívoros, artrópodos, peces y reptiles. Durante el Cenozoico dominó la depredación por parte de gasterópodos natícidos y murícidos y se reconoció también la depredación por parte de ar trópodos, peces y mamíferos.

  8. Silício alterando compostos derivados da pirólise de bainhas foliares de plantas de arroz infectadas por Rhizoctonia solani

    Directory of Open Access Journals (Sweden)

    Daniel Augusto Schurt

    Full Text Available Este trabalho teve como objetivo elucidar, por meio da pirólise analítica acoplada à cromatografia gasosa e espectrometria de massa, alterações na composição química da lignina nas bainhas de plantas de arroz das cultivares BR-Irga 409 e Labelle supridas ou não com silício (Si e infectadas por Rhizoctonia solani. A concentração de Si nas bainhas das plantas supridas com esse elemento foi significativamente maior (2,7 dag kg-1 em comparação com as plantas não supridas (0,45 dag kg-1. Na presença de Si, a área abaixo da curva do progresso da queima das bainhas foi significativamente reduzida em 19 e 25%, respectivamente, para as plantas das cultivares BR-Irga-409 e Labelle em relação à ausência desse elemento na solução nutritiva. Com base nos espectros de massas obtidos, foram identificados 33 compostos, dos quais 10 foram produtos da degradação de carboidratos e 23 derivados da lignina. Dentre os derivados da lignina, oito compostos eram do tipo p-hidroxifenila, 11 compostos do tipo guaiacila e quatro compostos do tipo siringila. Nas bainhas das plantas das duas cultivares de arroz, supridas ou não com Si, a concentração de lignina (p-hidroxifenila, siringila (S e guaiacila (G foi de, aproximadamente, 15%. Houve aumento na relação S/G apenas nas bainhas das plantas da cultivar BR-Irga 409 supridas com Si e infectadas por R. solani. A maior concentração de Si nas bainhas das plantas de arroz das duas cultivares, que por sua vez resultou em aumento na relação S/G, contribuiu para reduzir os sintomas da queima das bainhas.

  9. Uma última ruptura: o silêncio epistemológico de Bachelard após 1953 [The last rupture: Bachelard's epistemological silence after 1953

    Directory of Open Access Journals (Sweden)

    Gustavo Bertoche Guimarães

    2018-01-01

    Full Text Available Neste artigo, abordamos o problema do “silêncio epistemológico” de Gaston Bachelard (1884-1962 após 1953. Bachelard era um escritor prolífico: entre 1927 e 1953, concluiu 13 livros sobre epistemologia – cerca de um livro a cada 14 meses. Todavia, em certo momento deixou de publicar obras sobre o tema, embora tivesse continuado a escrever sobre a imaginação poética. Michel Vadée e Olival Freire notam o problema e indicam caminhos possíveis, mas deixam sua solução em aberto. Mais especificamente, Freire sugere que a questão pode estar relacionada a uma importante tomada de posição de Louis de Broglie, que, em 1952, rompe com a interpretação de Copenhagen (adotada por Bachelard, propondo uma teoria que admite uma solução não probabilista para a teoria quântica. Essa reviravolta por parte do mais importante físico francês pode ter abalado o espírito de Bachelard. Acreditamos ter encontrado, em um artigo de Bachelard publicado em 1957, elementos que permitem resolver a questão.   [In this paper, we address the problem of Gaston Bachelard’s (1884-1962 “epistemological silence” after 1953. Bachelard was a prolific writer: between 1927 and 1953, he completed 13 books on epistemology ‒ about one book every 14 months. However, at one point he stopped publishing works on the subject, although he continued to write about the poetic imagination. Michel Vadée and Olival Freire note the problem and point out possible paths, but leave their solution open. More specifically, Freire suggests that the issue may be related to an important position taken by Louis de Broglie, who, in 1952, breaks with the Copenhagen interpretation (adopted by Bachelard, proposing a theory that admits a non-probabilistic solution for Quantum theory. This turnaround by the most important French physicist may have shaken Bachelard's spirit. We believe we have found, in an article by Bachelard published in 1957, elements that allow us to resolve

  10. Locus of control and pain: Validity of the Form C of the Multidimensional Health Locus of Control scales when used with adolescents.

    Science.gov (United States)

    Castarlenas, Elena; Solé, Ester; Racine, Mélanie; Sánchez-Rodríguez, Elisabet; Jensen, Mark P; Miró, Jordi

    2016-09-01

    The objective of this study was to examine the factor structure, reliability, and validity of the Form C of the Multidimensional Health Locus of Control scales in adolescents. A confirmatory factor analysis indicated that adequate fit of a four-factor model and the internal consistency of the scales were adequate. Criterion validity of the four scales of the Form C of the Multidimensional Health Locus of Control was also supported by significant correlations with measures of pain-related self-efficacy, anxiety, and coping strategies. The results indicate that the four Form C of the Multidimensional Health Locus of Control scale scores are reliable and valid and therefore support their use to assess pain-related locus of control beliefs in adolescents.

  11. The fester locus in Botryllus schlosseri experiences selection

    Directory of Open Access Journals (Sweden)

    Nydam Marie L

    2012-12-01

    Full Text Available Abstract Background Allorecognition, the ability of an organism to distinguish self from non-self, occurs throughout the entire tree of life. Despite the prevalence and importance of allorecognition systems, the genetic basis of allorecognition has rarely been characterized outside the well-known MHC (Major Histocompatibility Complex in vertebrates and SI (Self-Incompatibility in plants. Where loci have been identified, their evolutionary history is an open question. We have previously identified the genes involved in self/non-self recognition in the colonial ascidian Botryllus schlosseri, and we can now begin to investigate their evolution. In B. schlosseri, colonies sharing 1 or more alleles of a gene called FuHC (Fusion Histocompatibility will fuse. Protein products of a locus called fester, located ~300 kb from FuHC, have been shown to play multiple roles in the histocompatibility reaction, as activating and/or inhibitory receptors. We test whether the proteins encoded by this locus are evolving neutrally or are experiencing balancing, directional, or purifying selection. Results Nearly all of the variation in the fester locus resides within populations. The 13 housekeeping genes (12 nuclear genes and mitochondrial cytochrome oxidase I have substantially more structure among populations within groups and among groups than fester. All polymorphism statistics (Tajima's D, Fu and Li's D* and F* are significantly negative for the East Coast A-type alleles, and Fu and Li's F* statistic is significantly negative for the West Coast A-type alleles. These results are likely due to selection rather than demography, given that 10 of the housekeeping loci have no populations with significant values for any of the polymorphism statistics. The majority of codons in the fester proteins have ω values 95% posterior probability of ω values > 1. Conclusion Fester proteins are evolving non-neutrally. The polymorphism statistics are consistent with either

  12. The mathematics behind biological invasions

    CERN Document Server

    Lewis, Mark A; Potts, Jonathan R

    2016-01-01

    This book investigates the mathematical analysis of biological invasions. Unlike purely qualitative treatments of ecology, it draws on mathematical theory and methods, equipping the reader with sharp tools and rigorous methodology. Subjects include invasion dynamics, species interactions, population spread, long-distance dispersal, stochastic effects, risk analysis, and optimal responses to invaders. While based on the theory of dynamical systems, including partial differential equations and integrodifference equations, the book also draws on information theory, machine learning, Monte Carlo methods, optimal control, statistics, and stochastic processes. Applications to real biological invasions are included throughout. Ultimately, the book imparts a powerful principle: that by bringing ecology and mathematics together, researchers can uncover new understanding of, and effective response strategies to, biological invasions. It is suitable for graduate students and established researchers in mathematical ecolo...

  13. Cheatgrass invasion and wildlife habitat

    Science.gov (United States)

    The introduction and subsequent invasion of cheatgrass (Bromus tectorum) has altered native plant communities and the wildlife species that depend on these communities. Cheatgrass has truncated secondary succession by outcompeting native plant species for limited resources, thus building persistent...

  14. Invasive Meningococcal Men Y Disease

    Centers for Disease Control (CDC) Podcasts

    2012-04-18

    Dr. Leonard Mayer, a public health microbiologist at CDC, discusses invasive meningococcal disease.  Created: 4/18/2012 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 4/23/2012.

  15. Locus of Control and Self-Esteem in Indian and White Students.

    Science.gov (United States)

    Martin, James C.

    1976-01-01

    The development and relationship of two dimensions of personality, self esteem and locus of control, were examined in a study of 763 fourth, eighth, and twelfth grade Indian and white children selected from 22 Oklahoma public schools. The students were given the Coopersmith Self-Esteem Inventory and Nowicky-Strickland Locus of Control Scale during…

  16. Relationship of Personality and Locus of Control With Employment Outcomes among Participants with Spinal Cord Injury

    Science.gov (United States)

    Krause, James S.; Broderick, Lynne

    2006-01-01

    We investigated relationships among personality, locus of control, and current post-injury employment status for 1,391 participants with spinal cord injury. Participants with higher internality locus-of-control scores and activity scores (personality) reported more favorable employment outcomes. Higher scores on chance and powerful others (locus…

  17. The Role of Locus of Control and Feedback on Performance of ...

    African Journals Online (AJOL)

    This study examined Students' Locus of Control and Teacher Feedback using a 2x3 factorial to measure the performance of thirty-six (36) primary school students utilizing the two locus of control types and three levels of teacher feedback: no feedback, attributional feedback, and progressive feedback. No significant ...

  18. The Relationship between the Perception of Own Locus of Control and Aggression of Adolescent Boys

    Science.gov (United States)

    Breet, Lettie; Myburgh, Chris; Poggenpoel, Marie

    2010-01-01

    Aggression is increasingly seen in most parts of South African society. Aggressive behaviour of boys in secondary school often results from frustrations caused by perceived high expectations of others regarding the role, locus of control, and personality of boys. Locus of control plays an important role in a person's perception concerning a…

  19. Predictors of Parental Locus of Control in Mothers of Pre- and Early Adolescents

    Science.gov (United States)

    Freed, Rachel D.; Tompson, Martha C.

    2011-01-01

    Parental locus of control refers to parents' perceived power and efficacy in child-rearing situations. This study explored parental locus of control and its correlates in 160 mothers of children ages 8 to 14 cross-sectionally and 1 year later. Maternal depression, maternal expressed emotion, and child internalizing and externalizing behavior were…

  20. Social Self-Efficacy, Academic Locus of Control, and Internet Addiction

    Science.gov (United States)

    Iskender, Murat; Akin, Ahmet

    2010-01-01

    The purpose of this research is to examine the relationship of internet addiction, social self-efficacy, and academic locus of control. Participants were 311 university students who completed a questionnaire package that included the Online Cognition Scale, the Academic Locus of Control Scale, and the Perceived Social Self-efficacy Scale. The…

  1. The genetic and regulatory architecture of ERBB3-type 1 diabetes susceptibility locus

    DEFF Research Database (Denmark)

    Kaur, Simranjeet; Mirza, Aashiq H.; Brorsson, Caroline Anna

    2016-01-01

    -producing INS-1E cells and the genetic and regulatory architecture of the ERBB3 locus to provide insights to how rs2292239 may confer disease susceptibility. rs2292239 strongly correlated with residual β-cell function and metabolic control in children with T1D. ERBB3 locus associated lncRNA (NONHSAG011351...

  2. Self Esteem, Locus of Control and Multidimensional Perfectionism as the Predictors of Subjective Well Being

    Science.gov (United States)

    Karatas, Zeynep; Tagay, Ozlem

    2012-01-01

    The purpose of this study is to determine whether there is a relationship between self-esteem, locus of control and multidimensional perfectionism, and the extent to which the variables of self-esteem, locus of control and multidimensional perfectionism contribute to the prediction of subjective well-being. The study was carried out with 318 final…

  3. A Study to Investigate the Relationship between Locus of Control and Academic Achievement of Students

    Science.gov (United States)

    Gujjar, Aijaz Ahmed; Aijaz, Rukhma

    2014-01-01

    Motivation is regarded as the alpha and omega of learning. It is the heart of teaching learning process. Motivation is defined as an internal state that arouses, directs, and maintains the behavior over time. Thus motivation is the pivotal component of learning and locus of control which is one of the important factors it stems from. Locus of…

  4. An Examination of Locus of Control, Epistemological Beliefs and Metacognitive Awareness in Preservice Early Childhood Teachers

    Science.gov (United States)

    Bedel, Emine Ferda

    2012-01-01

    This study aims to explore the locus of control, epistemological beliefs and metacognitive awareness levels of preservice early childhood education teachers and to determine the interrelations among these variables. 206 teacher candidates have been asked to fill out Rotter's Internal-External Locus of Control Scale, Central Epistemological Beliefs…

  5. Locus of Control as It Relates to the Teaching Style of Elementary Teachers

    Science.gov (United States)

    Ture, Abidemi

    2013-01-01

    This research explored the relationship between elementary teachers' locus of control and teaching style. This research observed elementary teachers in their classrooms coupled with data gathered from information sheets, surveys, and interviews to determine if a relationship exists between the locus of control of the elementary teachers and…

  6. Goal Orientations, Locus of Control and Academic Achievement in Prospective Teachers: An Individual Differences Perspective

    Science.gov (United States)

    Bulus, Mustafa

    2011-01-01

    The aim of this study is to investigate the role of the prospective teachers' locus of control in goal orientations and of both orientations in academic achievement. The participants were 270 undergraduate students studying in different majors at the Faculty of Education in Pamukkale University. Goal Orientations and Locus of Control Scales were…

  7. computer-aided root aided root aided root aided root-locus

    African Journals Online (AJOL)

    User

    equation are the same as the poles of the close loop system. Ideally, a desired performance can be achieved a control system by adjusting the location of roots in the s-plane by varying one or mo system parameters. Root-locus Method is a line. 8023278605. AIDED ROOT. AIDED ROOT-LOCUS NUMERICAL TECHNIQUE.

  8. An investigation of the HUMVWA31A locus in British Caucasians

    DEFF Research Database (Denmark)

    Drozd, M A; Archard, L; Lincoln, P J

    1994-01-01

    A number of short tandem repeat (STR) loci are currently being examined for their usefulness as markers of identity; HUMVWA31A is one such locus. We used a high-sieving agarose technique to type 200 British Caucasians for this locus. Comparison of the resultant allele frequencies with other...

  9. Locus of Control, Repression-Sensitization, and Psychological Disorder in Chronic Pain Patients.

    Science.gov (United States)

    McCreary, Charles; Turner, Judith

    1984-01-01

    Examined the relationship between locus of control and psychological disorder in chronic pain patients (N=59) through administration of Rotter's Internal-External Locus of Control Scale and the Minnesota Multiphasic Personality Inventory. Results suggested that both anxiety and a response set affect this population's rating of ability to control…

  10. The Effects of Test Format and Locus of Control on Test Anxiety.

    Science.gov (United States)

    Choi, Namok

    1998-01-01

    Investigates the joint effects of locus of control and test format on test anxiety with college students (N=86). Examines the relationship between students' attitudes toward test format and test anxiety. Results show no differential effect of locus of control on test anxiety across test format; students were more anxious about essay tests than…

  11. Locus of Control and Adjustment in Female Adult Survivors of Childhood Sexual Abuse.

    Science.gov (United States)

    Porter, Chebon A.; Long, Patricia J.

    1999-01-01

    A sample of 84 college women retrospectively reporting childhood sexual abuse and 285 women failing to report such a history participated in a study designed to investigate the relationship between victimization history and locus of control and the role of locus of control in predicting the adjustment of adult survivors of childhood sexual abuse.…

  12. Situational Factors and the Relationship Between Locus of Control and Psychological Adjustment

    Science.gov (United States)

    Gilbert, Lucia A.

    1976-01-01

    A model of psychological treatment increasing internality and regaining control over stressful environments was tested among college students. The two experiments assessed: (1) the locus of control regarding recent events and individual characteristics; and (2) the locus of control and manifest anxiety at pretreatment and posttreatment. Results…

  13. Fine-Scale Mapping of the FGFR2 Breast Cancer Risk Locus

    DEFF Research Database (Denmark)

    Meyer, Kerstin B; O'Reilly, Martin; Michailidou, Kyriaki

    2013-01-01

    The 10q26 locus in the second intron of FGFR2 is the locus most strongly associated with estrogen-receptor-positive breast cancer in genome-wide association studies. We conducted fine-scale mapping in case-control studies genotyped with a custom chip (iCOGS), comprising 41 studies (n = 89,050) of...

  14. Hubungan antara Locus Of Control dan Efektivitas Komunikasi antar Pribadi dengan Problem Focused Coping

    Directory of Open Access Journals (Sweden)

    Eko Sujadi

    2016-03-01

    Full Text Available Problem focused coping need to be possessed by every individual. The purposes of this research were to described locus of control, the effectiveness of interpersonal communication, problem focused coping,the correlation between locus of control with problem focused coping, andthe correlationbetween the effectiveness of interpersonal communication with problem focused coping.This research was descriptive & correlation research by using quantitative approach. Data were collected through a Likert scale questionaire and locus of controlby using inventory Rotters Internal-External Locus of Control (I-E Scale, which was the validity and reliability has been tested. The data were analyzed by percentage technique and product moment correlation. The finding of research are:  1locus of control were in the middle range between internal locus of control and external locus of control with an average as big as 11.46, 2 the general level of effectiveness of interpersonal communication is in high category, 3 the general level of problem focused coping is in high category, 4 there is correlation between locus of control withproblem focused coping, and 5 there is correlation betweeneffectiveness of interpersonal communicationwithproblem focused coping.

  15. A Locus of Control-based HIV and AIDS Risk Reduction Training ...

    African Journals Online (AJOL)

    The aim of this study was to investigate the effi cacy of a locus of control-based training programme in reducing HIV and AIDS risk among university students. The locus of control-based variables that formed the training programme were social systems control, deferment of gratifi cation, personal values and expectancies, ...

  16. Locus of Control, Death Anxiety and Length of Service of Electricity ...

    African Journals Online (AJOL)

    The findings indicated, that there was a statistically significant relationship between internal locus of control and death anxiety among short serving staff of Power Holding Company Nigeria, (r= 0.84, 38, P<.05). The second hypothesis showed a significant relationship between external locus of control and death anxiety ...

  17. Re-Examination of the Relationship between Locus of Control and Field Independence/Dependence.

    Science.gov (United States)

    Lau, Sing; And Others

    1981-01-01

    A total of 187 American and 90 Filipino college students were given Levenson's locus of control scales and the Thurstone's Gottschaldt hidden figures test. Consistent with past studies, no linear relationship between locus of control and field-independence was found. A similar curvilinear relationship was observed with both groups. (Author/SJL)

  18. Self-Efficacy And Locus Of Control As Predictors Of Academic ...

    African Journals Online (AJOL)

    The study investigated self-efficacy and locus of control as predictor of academic achievement among Junior Secondary school students in Osun state Unity schools, using Self-Efficacy Scale (SES) and Locus of Control Scale (LOC) as measuring instruments. The Cronbach alpha coefficient for validity of the two instruments ...

  19. The relationship between the perception of own locus of control and ...

    African Journals Online (AJOL)

    Aggression is increasingly seen in most parts of South African society. Aggressive behaviour of boys in secondary school often results from frustrations caused by perceived high expectations of others regarding the role, locus of control, and personality of boys. Locus of control plays an important role in a person's ...

  20. Authoritarian Child Rearing, Parental Locus of Control, and the Child's Behavior Style.

    Science.gov (United States)

    Janssens, Jan M. A. M.

    1994-01-01

    Examined relationships among childrearing, parental locus of control about childrearing, and child's behavior style. Found that parents who perceived their child's behavior as either externalizing or internalizing had a weak internal locus of control and were more authoritarian. Perceived externalizing child behavior was positively related to…

  1. Locus ceruleus neurons in people with autism contain no histochemically-detectable mercury.

    Science.gov (United States)

    Pamphlett, Roger; Kum Jew, Stephen

    2016-02-01

    Exposure to environmental mercury has been proposed to play a part in autism. Mercury is selectively taken up by the human locus ceruleus, a region of the brain that has been implicated in autism. We therefore looked for the presence of mercury in the locus ceruleus of people who had autism, using the histochemical technique of autometallography which can detect nanogram amounts of mercury in tissues. In addition, we sought evidence of damage to locus ceruleus neurons in autism by immunostaining for hyperphosphorylated tau. No mercury was found in any neurons of the locus ceruleus of 6 individuals with autism (5 male, 1 female, age range 16-48 years). Mercury was present in locus ceruleus neurons in 7 of 11 (64%) age-matched control individuals who did not have autism, which is significantly more than in individuals with autism. No increase in numbers of locus ceruleus neurons containing hyperphosphorylated tau was detected in people with autism. In conclusion, most people with autism have not been exposed early in life to quantities of mercury large enough to be found later in adult locus ceruleus neurons. Human locus ceruleus neurons are sensitive indicators of mercury exposure, and mercury appears to remain in these neurons indefinitely, so these findings do not support the hypothesis that mercury neurotoxicity plays a role in autism.

  2. Functional Analysis of the Coronary Heart Disease Risk Locus on Chromosome 21q22

    DEFF Research Database (Denmark)

    Beaney, Katherine E.; Smith, Andrew J. P.; Folkersen, Lasse Westergaard

    2017-01-01

    Background. The coronary heart disease (CHD) risk locus on 21q22 (lead SNP rs9982601) lies within a "gene desert." The aim of this study was to assess if this locus is associated with CHD risk factors and to identify the functional variant(s) and gene(s) involved. Methods. A phenome scan was perf...

  3. Non-Invasive Prenatal Testing

    OpenAIRE

    Ekici, Cemal

    2015-01-01

    The rate of newborns with trisomy 21 (Down syndrome) who have been referred to our pediatric newborn clinic is very high. This shows that prenatal screening in the region is not carried out well. Prenatal diagnosis and screening methods include invasive prenatal diagnosis methods (amniocentesis, chorionic villus sampling (CVS), and cordocentesis) and non-invasive prenatal diagnosis (NIPT) which cell free fetal DNA (cffDNA) screening of maternal blood samples. After the discovery of the signs ...

  4. Non-Invasive Prenatal Testing

    OpenAIRE

    McGillivray, Barbara C.

    1988-01-01

    The rate of newborns with trisomy 21 (Down syndrome) who have been referred to our pediatric newborn clinic is very high. This shows that prenatal screening in the region is not carried out well. Prenatal diagnosis and screening methods include invasive prenatal diagnosis methods (amniocentesis, chorionic villus sampling (CVS), and cordocentesis) and non-invasive prenatal diagnosis (NIPT) which cell free fetal DNA (cffDNA) screening of maternal blood samples. After the discovery of the signs ...

  5. Quantifying the invasiveness of species

    Czech Academy of Sciences Publication Activity Database

    Colautti, R. I.; Parker, J. D.; Cadotte, M. W.; Pyšek, Petr; Brown, C. S.; Sax, D. F.; Richardson, D. M.

    2014-01-01

    Roč. 21, č. 1 (2014), s. 7-27 ISSN 1619-0033 R&D Projects: GA ČR(CZ) GAP505/11/1112; GA ČR(CZ) GAP504/11/1028 Grant - others:AV ČR(CZ) AP1002 Program:Akademická prémie - Praemium Academiae Institutional support: RVO:67985939 Keywords : biological invasions * biogeographical comparison * invasiveness Subject RIV: EH - Ecology, Behaviour

  6. Membrane protein expression triggers chromosomal locus repositioning in bacteria

    Science.gov (United States)

    Libby, Elizabeth A.; Roggiani, Manuela; Goulian, Mark

    2012-01-01

    It has long been hypothesized that subcellular positioning of chromosomal loci in bacteria may be influenced by gene function and expression state. Here we provide direct evidence that membrane protein expression affects the position of chromosomal loci in Escherichia coli. For two different membrane proteins, we observed a dramatic shift of their genetic loci toward the membrane upon induction. In related systems in which a cytoplasmic protein was produced, or translation was eliminated by mutating the start codon, a shift was not observed. Antibiotics that block transcription and translation similarly prevented locus repositioning toward the membrane. We also found that repositioning is relatively rapid and can be detected at positions that are a considerable distance on the chromosome from the gene encoding the membrane protein (>90 kb). Given that membrane protein-encoding genes are distributed throughout the chromosome, their expression may be an important mechanism for maintaining the bacterial chromosome in an expanded and dynamic state. PMID:22529375

  7. A novel stroke locus identified in a northern Sweden pedigree

    DEFF Research Database (Denmark)

    Janunger, T.; Nilsson-Ardnor, S.; Wiklund, P.-G.

    2009-01-01

    OBJECTIVES: The population of northern Sweden is characterized by reduced genetic diversity and a high incidence of stroke. We sought to reduce genetic variation further, using genealogic analysis in a set of nuclear families affected by stroke, and we subsequently performed a genome-wide scan...... to identify novel stroke susceptibility loci. METHODS: Through genealogy, 7 nuclear families with a common ancestor, connected over 8 generations, were identified. A genome-wide scan using 449 microsatellite markers was performed with subsequent haplotype analyses. RESULTS: A maximum allele-sharing lod score...... of 4.81 on chromosome 9q31-q33 was detected. Haplotype analysis identified a common 2.2-megabase interval in the chromosomal region in 4 of the nuclear families, where an overrepresentation of intracerebral hemorrhage was observed. CONCLUSIONS: We have identified a novel susceptibility locus for stroke...

  8. Natural history of the ERVWE1 endogenous retroviral locus

    Directory of Open Access Journals (Sweden)

    Duret Laurent

    2005-09-01

    Full Text Available Abstract Background The human HERV-W multicopy family includes a unique proviral locus, termed ERVWE1, whose full-length envelope ORF was preserved through evolution by the action of a selective pressure. The encoded Env protein (Syncytin is involved in hominoid placental physiology. Results In order to infer the natural history of this domestication process, a comparative genomic analysis of the human 7q21.2 syntenic regions in eutherians was performed. In primates, this region was progressively colonized by LTR-elements, leading to two different evolutionary pathways in Cercopithecidae and Hominidae, a genetic drift versus a domestication, respectively. Conclusion The preservation in Hominoids of a genomic structure consisting in the juxtaposition of a retrotransposon-derived MaLR LTR and the ERVWE1 provirus suggests a functional link between both elements.

  9. Measurement of locus copy number by hybridisation with amplifiable probes

    Science.gov (United States)

    Armour, John A. L.; Sismani, Carolina; Patsalis, Philippos C.; Cross, Gareth

    2000-01-01

    Despite its fundamental importance in genome analysis, it is only recently that systematic approaches have been developed to assess copy number at specific genetic loci, or to examine genomic DNA for submicroscopic deletions of unknown location. In this report we show that short probes can be recovered and amplified quantitatively following hybridisation to genomic DNA. This simple observation forms the basis of a new approach to determining locus copy number in complex genomes. The power and specificity of multiplex amplifiable probe hybridisation is demonstrated by the simultaneous assessment of copy number at a set of 40 human loci, including detection of deletions causing Duchenne muscular dystrophy and Prader–Willi/Angelman syndromes. Assembly of other probe sets will allow novel, technically simple approaches to a wide variety of genetic analyses, including the potential for extension to high resolution genome-wide screens for deletions and amplifications. PMID:10606661

  10. Parasite spillover: indirect effects of invasive Burmese pythons.

    Science.gov (United States)

    Miller, Melissa A; Kinsella, John M; Snow, Ray W; Hayes, Malorie M; Falk, Bryan G; Reed, Robert N; Mazzotti, Frank J; Guyer, Craig; Romagosa, Christina M

    2018-01-01

    Identification of the origin of parasites of nonindigenous species (NIS) can be complex. NIS may introduce parasites from their native range and acquire parasites from within their invaded range. Determination of whether parasites are non-native or native can be complicated when parasite genera occur within both the NIS' native range and its introduced range. We explored potential for spillover and spillback of lung parasites infecting Burmese pythons ( Python bivittatus ) in their invasive range (Florida). We collected 498 indigenous snakes of 26 species and 805 Burmese pythons during 2004-2016 and examined them for lung parasites. We used morphology to identify three genera of pentastome parasites, Raillietiella , a cosmopolitan form, and Porocephalus and Kiricephalus , both New World forms. We sequenced these parasites at one mitochondrial and one nuclear locus and showed that each genus is represented by a single species, R. orientalis , P. crotali , and K. coarctatus . Pythons are host to R. orientalis and P. crotali , but not K. coarctatus ; native snakes are host to all three species. Sequence data show that pythons introduced R. orientalis to North America, where this parasite now infects native snakes. Additionally, our data suggest that pythons are competent hosts to P. crotali , a widespread parasite native to North and South America that was previously hypothesized to infect only viperid snakes. Our results indicate invasive Burmese pythons have affected parasite-host dynamics of native snakes in ways that are consistent with parasite spillover and demonstrate the potential for indirect effects during invasions. Additionally, we show that pythons have acquired a parasite native to their introduced range, which is the initial condition necessary for parasite spillback.

  11. Deciphering the Routes of invasion of Drosophila suzukii by Means of ABC Random Forest

    Science.gov (United States)

    Fraimout, Antoine; Debat, Vincent; Fellous, Simon; Hufbauer, Ruth A.; Foucaud, Julien; Pudlo, Pierre; Marin, Jean-Michel; Price, Donald K.; Cattel, Julien; Chen, Xiao; Deprá, Marindia; François Duyck, Pierre; Guedot, Christelle; Kenis, Marc; Kimura, Masahito T.; Loeb, Gregory; Loiseau, Anne; Martinez-Sañudo, Isabel; Pascual, Marta; Polihronakis Richmond, Maxi; Shearer, Peter; Singh, Nadia; Tamura, Koichiro; Xuéreb, Anne; Zhang, Jinping

    2017-01-01

    Abstract Deciphering invasion routes from molecular data is crucial to understanding biological invasions, including identifying bottlenecks in population size and admixture among distinct populations. Here, we unravel the invasion routes of the invasive pest Drosophila suzukii using a multi-locus microsatellite dataset (25 loci on 23 worldwide sampling locations). To do this, we use approximate Bayesian computation (ABC), which has improved the reconstruction of invasion routes, but can be computationally expensive. We use our study to illustrate the use of a new, more efficient, ABC method, ABC random forest (ABC-RF) and compare it to a standard ABC method (ABC-LDA). We find that Japan emerges as the most probable source of the earliest recorded invasion into Hawaii. Southeast China and Hawaii together are the most probable sources of populations in western North America, which then in turn served as sources for those in eastern North America. European populations are genetically more homogeneous than North American populations, and their most probable source is northeast China, with evidence of limited gene flow from the eastern US as well. All introduced populations passed through bottlenecks, and analyses reveal five distinct admixture events. These findings can inform hypotheses concerning how this species evolved between different and independent source and invasive populations. Methodological comparisons indicate that ABC-RF and ABC-LDA show concordant results if ABC-LDA is based on a large number of simulated datasets but that ABC-RF out-performs ABC-LDA when using a comparable and more manageable number of simulated datasets, especially when analyzing complex introduction scenarios. PMID:28122970

  12. How Multidimensional Health Locus of Control predicts utilization of emergency and inpatient hospital services.

    Science.gov (United States)

    Mautner, Dawn; Peterson, Bridget; Cunningham, Amy; Ku, Bon; Scott, Kevin; LaNoue, Marianna

    2017-03-01

    Health locus of control may be an important predictor of health care utilization. We analyzed associations between health locus of control and frequency of emergency department visits and hospital admissions, and investigated self-rated health as a potential mediator. Overall, 863 patients in an urban emergency department completed the Multidimensional Health Locus of Control instrument, and self-reported emergency department use and hospital admissions in the last year. We found small but significant associations between Multidimensional Health Locus of Control and utilization, all of which were mediated by self-rated health. We conclude that interventions to shift health locus of control may change patients' perceptions of their own health, thereby impacting utilization.

  13. The Contribution of Locus of Control to Academic Procrastination in Islamic Education Management Students in Indonesia

    Directory of Open Access Journals (Sweden)

    Juliana Batubara

    2017-02-01

    Full Text Available This study aimed to describe the locus of control and academic procrastination, and investigate whether there is significance contributions of locus of control on student academic procrastination. This research was conducted by the Ex post-facto method was used in this study, where the data taken from two set of questionnaires. Proportional Stratified Random Sampling was used. There were 107 students involved this study. The results showed that the locus of control is in average level, meanwhile, and the students’ academic achievement was high. The study also showed that there is a significant contribution between the locus of control on students' academic procrastination. The article concludes that the importance that locus control for procrastination research, and with suggestions for educators who work with students who are adversely affected by procrastination.

  14. Effect of cocaine on ion channels and glutamatergic EPSCs in noradrenergic locus coeruleus neurons.

    Science.gov (United States)

    Liu, L N; Zhu, F P; Song, M Y; Kang, X J; Shang, S J; Zhang, X Y; Xu, H D; Teng, S S; Liu, B; Kuo, S T; Liu, W; Li, M L; Zhou, L; Jiao, R Y; Wang, C H; Wang, S R; Yang, H; Zhang, B; Zhou, Z; Xu, Z Q D

    2014-07-01

    The locus coeruleus (LC) is an important brainstem area involved in cocaine addiction. However, evidence to elucidate how cocaine modulates the activity of LC neurons remains incomplete. Here, we performed whole recordings in brain slices to evaluate the effects of cocaine on the sodium (Na(+)), potassium (K(+)), calcium (Ca(2+)) channels, and glutamatergic synaptic transmission in the locus coeruleus neurons. Local application of cocaine significantly and reversibly reduced the spontaneous firing rate but did not affect action potential amplitude, rising time, decay time, or half width of noradrenergic locus coeruleus neurons. Moreover, cocaine attenuated the sodium current but did not affect potassium and calcium currents. The N-methyl-D-aspartate receptor mediated excitatory postsynaptic currents were reduced by neuropeptide galanin but not cocaine. All those data demonstrate that cocaine has inhibitory effect on the spontaneous activities and sodium current in locus coeruleus neurons. Therefore, neuromodulation of sodium channel in locus coeruleus neurons may play an important role in drug addiction.

  15. Is the novel SCKL3 at 14q23 the predominant Seckel locus?

    Science.gov (United States)

    Kilinç, Mehmet Okyay; Ninis, Vasiliki Ninidu; Ugur, Sibel Aylin; Tüysüz, Beyhan; Seven, Mehmet; Balci, Sevim; Goodship, Judith; Tolun, Aslihan

    2003-11-01

    Seckel syndrome (SCKL) is a rare disease with wide phenotypic heterogeneity. A locus (SCKL1) has been identified at 3q and another (SCKL2) at 18p, both in single kindreds afflicted with the syndrome. We report here a novel locus (SCKL3) at 14q by linkage analysis in 13 Turkish families. In total, 18 affected and 10 unaffected sibs were included in the study. Of the 10 informative families, nine with parental consanguinity and one reportedly nonconsanguineous but with two affected sibs, five were indicative of linkage to the novel locus. One of those families also linked to the SCKL1 locus. A consanguineous family with one affected sib was indicative of linkage to SCKL2. The novel gene locus SCKL3 is 1.18 cM and harbors ménage a trois 1, a gene with a role in DNA repair.

  16. Imágenes (políticas de vida: ¿el animal?, ¿el fósil? Figuras del prisma poshumano en la obra de Nuno Ramos

    Directory of Open Access Journals (Sweden)

    Victoria Cóccaro

    2017-07-01

    Full Text Available El presente artículo analiza la figura del fósil en algunas obras del artista brasileño Nuno Ramos, a partir del debate abierto en la crítica literaria de los últimos años denominado giro animal. Desde el campo de los estudios posthumanistas, el fósil permite articular un pensamiento sobre la vida distinto a la Forma Hombre moderna, interpela sobre las nociones de vida y demanda la necesidad, entonces, de crear modos de lectura y lenguajes: ¿Cómo leer un tiempo y un espacio más allá de lo humano, desde lo (poshumano? Nuno Ramos trabajará con el tacto (como lectura que excede a lo lingüístico y la materia (como lenguaje con asignificantes en obras plásticas y escritas que dan tratamiento al lenguaje y a los materiales plásticos como minerales o fósiles, materias que erosionan los límites entre lo orgánico y lo inorgánico, lo vivo y lo muerto.

  17. Surface-site-selective study of valence electronic structures of clean Si(100)-2x1 using Si-L23VV Auger electron-Si-2p photoelectron coincidence spectroscopy

    International Nuclear Information System (INIS)

    Kakiuchi, Takuhiro; Nagaoka, Shinichi; Hashimoto, Shogo; Fujita, Narihiko; Tanaka, Masatoshi; Mase, Kazuhiko

    2010-01-01

    Valence electronic structures of a clean Si(100)-2x1 surface are investigated in a surface-site-selective way using Si-L 23 VV Auger electron-Si-2p photoelectron coincidence spectroscopy. The Si-L 23 VV Auger electron spectra measured in coincidence with Si-2p photoelectrons emitted from the Si up-atoms or Si 2nd-layer of Si(100)-2x1 suggest that the position where the highest density of valence electronic states located in the vicinity of the Si up-atoms is shifted by 0.8 eV towards lower binding energy relative to that in the vicinity of the Si 2nd-layer. Furthermore, the valence band maximum in the vicinity of the Si up-atoms is indicated to be shifted by 0.1 eV towards lower binding energy relative to that in the vicinity of the Si 2nd-layer. These results are direct evidence of the transfer of negative charge from the Si 2nd-layer to the Si up-atoms. (author)

  18. 75 FR 69698 - Invasive Species Advisory Committee

    Science.gov (United States)

    2010-11-15

    ... DEPARTMENT OF THE INTERIOR Office of the Secretary Invasive Species Advisory Committee AGENCY: Office of the Secretary, Interior. ACTION: Notice of public meetings of the Invasive Species Advisory... of meetings of the Invasive Species Advisory Committee (ISAC). Comprised of 30 nonfederal invasive...

  19. 76 FR 68776 - Invasive Species Advisory Committee

    Science.gov (United States)

    2011-11-07

    ... DEPARTMENT OF THE INTERIOR Office of the Secretary Invasive Species Advisory Committee AGENCY: Office of the Secretary, Interior. ACTION: Notice of public meetings of the Invasive Species Advisory... of meetings of the Invasive Species Advisory Committee (ISAC). Comprised of 29 nonfederal invasive...

  20. 77 FR 23740 - Invasive Species Advisory Committee

    Science.gov (United States)

    2012-04-20

    ... DEPARTMENT OF THE INTERIOR Office of the Secretary Invasive Species Advisory Committee AGENCY: Office of the Secretary, Interior. ACTION: Notice of Public Meetings of the Invasive Species Advisory... of meetings of the Invasive Species Advisory Committee (ISAC). Comprised of 30 nonfederal invasive...

  1. Silício e imidacloprid na colonização de plantas por Myzus persicae e no desenvolvimento vegetativo de batata inglesa Silicon and imidacloprid on plants colonized by Myzus persicae and on vegetative development of potato

    Directory of Open Access Journals (Sweden)

    Flávia Batista Gomes

    2008-08-01

    Full Text Available O pulgão Myzus persicae (Sulzer é considerado praga-chave da cultura da batata inglesa, cuja produtividade depende do uso de inseticidas para o seu controle. Este trabalho foi conduzido para verificar o efeito do silício e do imidaclopride na colonização de plantas por M. persicae e seus possíveis reflexos positivos no desenvolvimento da batata inglesa. Foram testados cinco tratamentos, com sete repetições: 1- testemunha; 2- ácido silícico a 1%; 3- imidacloprid na dosagem recomendada (252g ha-1; 4- ácido silícico a 1% e imidacloprid na metade da dosagem recomendada (126g ha-1; e 5- imidaclopride na metade da dosagem recomendada (126g ha-1. Após 20 dias do plantio, as plantas (cv. Emeraude foram infestadas com dez pulgões adultos. Avaliaram-se, após 20 dias da infestação, o número de ninfas e de adultos de pulgões, a altura, o diâmetro, o número de folhas e a fitomassa fresca e seca das plantas. As plantas tratadas com o inseticida foram pouco colonizadas pelos pulgões e aquelas tratadas com silício apresentaram menor infestação em relação à testemunha. Em relação à altura, ao diâmetro e à fitomassa, não houve diferença significativa entre os tratamentos, porém a testemunha apresentou menor número de folhas. Assim, o silício diminuiu a colonização da batata por M. persicae e o uso da metade da dosagem recomendada de imidacloprid (126g ha-1 foi igualmente eficiente para impedir a colonização, tornando a adubação silicatada mais uma tática a ser testada no manejo integrado de pragas da batateira.The aphid Myzus persicae (Sulzer is a key pest of potato crops, the yield of which depends on insecticides for its control. This research was carried out to verify the effect of silicon and imidacloprid on the colonization of potato plants by M. persicae and its possible positive consequences on development parameters. Five treatments with seven replications were tested: 1- control treatment; 2- 1% silicic acid

  2. Interação entre silício e nitrogênio em arroz cultivado sob solução nutritiva Silicon-nitrogen interaction in rice cultivated under nutrient solution

    Directory of Open Access Journals (Sweden)

    Fabrício William Ávila

    2010-06-01

    Full Text Available O presente estudo objetivou avaliar o efeito da interação entre silício e nitrogênio nos teores de clorofila, nitrato, amônio e nitrogênio total, na produção de biomassa e nos números de perfilhos e de panículas em arroz cultivado em solução nutritiva. Utilizou-se o delineamento inteiramente casualizado em esquema fatorial 5 x 2, sendo duas concentrações de silício (0 e 50 mg L-1 e cinco as de nitrogênio (20; 50; 100; 200 e 400 mg L-1, com três repetições. No estádio de formação do colar da folha bandeira foram realizadas a leitura SPAD e as determinações dos teores de clorofila a e b, nitrogênio nítrico, amoniacal e total. No estádio de maturidade completa da panícula, foram avaliados os números de perfilhos e de panículas e determinaram-se os pesos de matéria seca de raiz e parte aérea e o acúmulo de silício na planta. Os resultados mostraram que o fornecimento de silício não alterou o perfilhamento, a produção de matéria seca e os teores de nitrogênio total. O silício elevou os valores SPAD, os teores de clorofila a e b, os teores de nitrato nas raízes e o número de panículas, especialmente em doses elevadas de nitrogênio.The present study aimed to evaluate the interaction effect between silicon and nitrogen in the content of chlorophyll, nitrate, ammonium and total nitrogen, dry matter production, number of tillers and number of panicles rice-plant cultivated in nutritional solution. A factorial design 5 x 2 trial installed in a completely randomized design was used being two silicon (0 and 50mg L-1 and five nitrogen (20; 50; l00; 200 and 400 mg L-1 concentrations. In the stadium of the flag leaf collar formation SPDA reading and the a and b chlorophyll contents, ammoniacal and total nitrogen determinations in plants were detemined. During the panicle complete maturity stadium, the number of tillers and panicles were evaluated and the aerial part and root dry matter contents and silicon

  3. Invasive amphibians in southern Africa: A review of invasion pathways

    Directory of Open Access Journals (Sweden)

    John Measey

    2017-03-01

    Full Text Available Background: Globally, invasive amphibians are known for their environmental and social impacts that range from poisoning of local fauna and human populations to direct predation on other amphibians. Although several countries on most continents have had multiple introductions of many species, southern Africa appears to have escaped allochthonous introductions. Instead, it has a small number of domestic exotic species that have rapidly expanded their ranges and established invasive populations within South Africa. Objectives & methods: We used the literature to provide a historical overview of dispersal by some of the world’s major invasive amphibians, give examples of species that are commonly moved as stowaways and discuss historical and current amphibian trade in the region. In addition, we give an overview of new South African legislation and how this is applied to amphibian invasions, as well as providing updates on the introduced populations of three domestic exotics: Hyperolius marmoratus, Sclerophrys gutturalis and Xenopus laevis. Results: We show that frogs are mainly moved around southern Africa through ‘jump’ dispersal, although there are a number of records of ‘cultivation’, ‘leading-edge’ and ‘extreme long-distance’ dispersal types. Important pathways include trade in fruit and vegetables, horticultural products and shipping containers. Conclusion: We suggest that southern Africa is becoming more vulnerable to amphibian invasions because of an increase in trade, agricultural and domestic impoundments as well as global climate change. Increasing propagule pressure suggests that preventing new introductions will become a key challenge for the future. Currently, trade in amphibians in the region is practically non-existent, suggesting potential for best practice to prevent importation of species with high invasion potential and to stop the spread of disease.

  4. The Relationship of Locus of Control, Age, and Sex to Life Satisfaction and Death Anxiety in Older Persons.

    Science.gov (United States)

    Hickson, Joyce; And Others

    1988-01-01

    Examined Rotter's Internal-External locus of control concept in relation to life satisfaction and death anxiety in aged population (N=122). Found strong gender and locus of control effect for life satisfaction. For death anxiety, found strong gender effect and significant interaction between locus of control and age. Suggests need for life span…

  5. Anesthesia for minimally invasive neurosurgery.

    Science.gov (United States)

    Prabhakar, Hemanshu; Mahajan, Charu; Kapoor, Indu

    2017-10-01

    With an ultimate aim of improving patients overall outcome and satisfaction, minimally invasive surgical approach is becoming more of a norm. The related anesthetic evidence has not expanded at the same rate as surgical and technological advancement. This article reviews the recent evidence on anesthesia and perioperative concerns for patients undergoing minimally invasive neurosurgery. Minimally invasive cranial and spinal surgeries have been made possible only by vast technological development. Points of surgical interest can be precisely located with the help of stereotaxy and neuronavigation and special endoscopes which decrease the tissue trauma. The principles of neuroanethesia remain the same, but few concerns are specific for each technique. Dexmedetomidine has a favorable profile for procedures carried out under sedation technique. As the new surgical techniques are coming up, lesser known anesthetic concerns may also come into light. Over the last year, little new information has been added to existing literature regarding anesthesia for minimally invasive neurosurgeries. Neuroanesthesia goals remain the same and less invasive surgical techniques do not translate into safe anesthesia. Specific concerns for each procedure should be taken into consideration.

  6. Interstitial guidance of cancer invasion.

    Science.gov (United States)

    Gritsenko, Pavlo G; Ilina, Olga; Friedl, Peter

    2012-01-01

    Cancer cell invasion into healthy tissues develops preferentially along pre-existing tracks of least resistance, followed by secondary tissue remodelling and destruction. The tissue scaffolds supporting or preventing guidance of invasion vary in structure and molecular composition between organs. In the brain, the guidance is provided by myelinated axons, astrocyte processes, and blood vessels which are used as invasion routes by glioma cells. In the human breast, containing interstitial collagen-rich connective tissue, disseminating breast cancer cells preferentially invade along bundled collagen fibrils and the surface of adipocytes. In both invasion types, physical guidance prompted by interfaces and space is complemented by molecular guidance. Generic mechanisms shared by most, if not all, tissues include (i) guidance by integrins towards fibrillar interstitial collagen and/or laminins and type IV collagen in basement membranes decorating vessels and adipocytes, and, likely, CD44 engaging with hyaluronan; (ii) haptotactic guidance by chemokines and growth factors; and likely (iii) physical pushing mechanisms. Tissue-specific, resticted guidance cues include ECM proteins with restricted expression (tenascins, lecticans), cell-cell interfaces, and newly secreted matrix molecules decorating ECM fibres (laminin-332, thrombospondin-1, osteopontin, periostin). We here review physical and molecular guidance mechanisms in interstitial tissue and brain parenchyma and explore shared principles and organ-specific differences, and their implications for experimental model design and therapeutic targeting of tumour cell invasion. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

  7. Mecanismos bioquímicos da defesa do algodoeiro à mancha de ramulária mediados pelo silício

    Directory of Open Access Journals (Sweden)

    Carmen Rosa da Silva Curvêlo

    2013-03-01

    Full Text Available Esse estudo investigou o efeito do silício (Si na resistência do algodoeiro à mancha de ramulária (Ramularia areola. Plantas de algodoeiro (cvs. NuOpal e BRS Buriti foram cultivadas em solução nutritiva nas concentrações de 0 (-Si e 2 mM Si L-1 (+Si e aos 30 dias após emergência foram submetidas à inoculação com uma suspensão de conídios de R. areola. Avaliou-se o período de incubação (PI, o período latente (PL60, a severidade, o número de lesões (NL por cm² de folha, o tamanho de lesão (TL, a concentração foliar de Si e as atividades das enzimas de defesa peroxidases (POX, polifenoloxidases (PFO, quitinases (QUI, β-1,3-glucanases (GLU e fenilalanina amônia-liases (FAL. Os dados de severidade foram usados para calcular a área abaixo da curva do progresso da mancha de ramulária (AACPMR. A concentração foliar de Si aumentou em 64% nas plantas supridas com Si em relação às não supridas com esse elemento. Houve aumentos de 10% e 14,7%, respectivamente, para o PI e o PL60 nas plantas supridas com Si. Reduções de 38,6% e 62,4% para o NL e de 17,2% e 26,6% para o TL ocorrem, respectivamente, nas plantas das cvs. NuOpal e BRS Buriti supridas com Si. Houve redução de 35% na AACPMR para as plantas supridas com Si em relação às não supridas. A concentração de compostos fenólicos solúveis totais nas plantas das duas cultivares supridas com Si foi maior aos 21 dias após inoculação (dai em relação às não supridas com esse elemento. A concentração dos derivados da lignina foi maior dos 15 aos 21 dai apenas para as plantas da cv. BRS Buriti supridas com Si. A atividade da POX foi maior nas plantas das duas cultivares supridas com Si em relação às não supridas com esse elemento dos 15 aos 21 dai. Paras as plantas da cv. NuOpal supridas com Si, as atividades da PFO, QUI, GLU e FAL aumentaram aos 18 dai. As atividades da PFO e da FAL nas plantas da cv. BRS Buriti não foram potencializadas pelo Si. Nas

  8. The Relationship between Health Locus of Control and Health Behaviors in Emergency Medicine Personnel.

    Science.gov (United States)

    Pourhoseinzadeh, Mansour; Gheibizadeh, Mahin; Moradikalboland, Mehrnaz

    2017-10-01

    Health locus of control defined as individual beliefs based on past experiences in health issues and having external or internal control over them, could affect health. Health locus of control plays a role in health behaviors. We aimed to investigate the relationship between health locus of control and health behavior in emergency medical personnel in Ahvaz during 2016. This is a cross-sectional descriptive study, which began in August 2016 for a period of six months on 215 emergency medical personnel in Ahvaz who were selected randomly. The data were collected by a demographic questionnaire, Rotter's locus of control questionnaire, and health behavior questionnaire and analyzed using SPSS software, version 22. The correlation between variables was estimated by Pearson's correlation coefficient and independent t test. The level of significance for all statistical tests was set at 0.05. We found no significant relationship between health locus of control (external and internal) and health behavior (P>0.05).Health behaviors were very good in terms of personal health (86.5%), nutrition (53%), and sleep and rest (48.4%), and poor in terms of physical activity (52.6%) and stress management (79.5%). Furthermore, 79.5% of the emergency personnel, in general, had poor heath behaviors. Leaders and officials in the field of health must necessarily design programs in relation to health locus of control and the factors developing and affecting it as well as the role of health locus of control in doing correct behaviors.

  9. Weight loss maintenance in relation to locus of control: The MedWeight study.

    Science.gov (United States)

    Anastasiou, Costas A; Fappa, Evaggelia; Karfopoulou, Eleni; Gkza, Anastasia; Yannakoulia, Mary

    2015-08-01

    Locus of control, i.e. the degree of an individual's belief on the control of his/her life, has been related to many health outcomes, including weight loss in overweight/obese individuals. No information is available on the impact of locus of control in maintaining weight loss. We aimed to investigate the effect of locus of control in weight loss maintenance and explore potential associations with lifestyle factors. Study participants included 239 individuals (41% males) who had lost at least 10% of body weight in the past and either maintained the loss (maintainers: weight maintenance of at least 10% of initial weight) or regained it (regainers). Locus of control was defined by a relevant multi-dimensional scale; participants were categorised to internals and externals, based on "internal" and "others" sub-scales. A significant interaction was found between locus of control and weight loss maintenance status (p locus of control. Individualised treatment, according to locus of control, may increase weight loss maintenance rates in former overweight/obese individuals. Copyright © 2015 Elsevier Ltd. All rights reserved.

  10. Work stress and emotional exhaustion in nurses: the mediating role of internal locus of control.

    Science.gov (United States)

    Partlak Günüşen, Neslihan; Ustün, Besti; Erdem, Sabri

    2014-01-01

    Burnout is a major problem for nursing. There is a strong relationship between work stress and emotional exhaustion. Although studies report a negative correlation between the internal locus of control and emotional exhaustion and work stress, the number of studies available on the subject is limited. This study intends to examine the extent to which the relationship between work stress and emotional exhaustion is mediated by nurses' internal locus of control. The study adopted a cross-sectional survey design. The data were analyzed using structural equation modeling techniques. The study sample consisted of 347 nurses who worked in a university hospital in Izmir, Turkey and who agreed to participate in the study. The Work-Related Strain Inventory was used to evaluate the nurses' work stress level, Maslach Burnout Inventory was used to evaluate their emotional exhaustion levels, and the Locus of Control Scale was used to evaluate the internal locus of control. The variables of the study were based on the Neuman Systems Model. Work stress was positively related to internal locus of control (β3 = .21, p 0.1). Internal locus of control was negatively related to emotional exhaustion (β = -.14, p Work stress is directly (β = .87, p Work stress is directly (β = .87, p work stress was mediated, the impact of internal locus of control was limited. It is recommended that different variables be included in future studies so that they can mediate the relationship between work stress and emotional exhaustion.

  11. Internal health locus of control predicts willingness to track health behaviors online and with smartphone applications.

    Science.gov (United States)

    Bennett, Brooke L; Goldstein, Carly M; Gathright, Emily C; Hughes, Joel W; Latner, Janet D

    2017-12-01

    Given rising technology use across all demographic groups, digital interventions offer a potential strategy for increasing access to health information and care. Research is lacking on identifying individual differences that impact willingness to use digital interventions, which may affect patient engagement. Health locus of control, the amount of control an individual believes they have over their own health, may predict willingness to use mobile health (mHealth) applications ('apps') and online trackers. A cross-sectional study (n = 276) was conducted to assess college students' health locus of control beliefs and willingness to use health apps and online trackers. Internal and powerful other health locus of control beliefs predicted willingness to use health apps and online trackers while chance health locus of control beliefs did not. Individuals with internal and powerful other health locus of control beliefs are more willing than those with chance health locus of control beliefs to utilize a form of technology to monitor or change health behaviors. Health locus of control is an easy-to-assess patient characteristic providers can measure to identify which patients are more likely to utilize mHealth apps and online trackers.

  12. The retinal locus of fixation in simulations of progressing central scotomas.

    Science.gov (United States)

    Barraza-Bernal, Maria J; Rifai, Katharina; Wahl, Siegfried

    2018-01-01

    Patients with central scotoma use a preferred retinal locus (PRL) of fixation to perform visual tasks. Some of the conditions that cause central scotoma are progressive, and as a consequence, the PRL needs to be adjusted throughout the progression. The present study investigates the peripheral locus of fixation in subjects under a simulation of progressive central scotoma. Five normally sighted subjects participated in the study. A foveally centered mask of varying size was presented to simulate the scotoma. Initially, subjects developed a peripheral locus of fixation under simulation of a 6° scotoma, which was used as a baseline. The progression was simulated in two separate conditions: a gradual progression and an abrupt progression. In the gradual progression, the diameter of the scotoma increased by a fixed amount of either 1° or 2° of visual angle, thus scotomas of 8°, 10°, and 11° of visual angle were simulated. In the abrupt progression, the diameter was adjusted individually to span the area of the visual field used by the current peripheral locus of fixation. Subjects located the peripheral locus of fixation along the same meridian under simulation of scotoma progression. Furthermore, no differences between the fixation stability of the baseline locus of fixation and the incremental progression locus of fixation were found whereas, in abrupt progression, the fixation stability decreased significantly. These results provide first insight into fixation behavior in a progressive scotoma and may contribute to the development of training tools for patients with progressive central maculopathies.

  13. Relationship of emotional intelligence and health locus of control among female breast cancer patients in pakistan

    International Nuclear Information System (INIS)

    Naz, R.; Kamal, A.

    2016-01-01

    Objective: To investigate relationship between emotional intelligence and health locus of control in married women with breast cancer disease. Study Design: Cross sectional study. Place and Duration of Study: The data was collected from Nuclear Oncology and Radiology Institute (NORI Hospital) Islamabad (n=210) and from Combined Military Hospital (CMH) Rawalpindi (n=101). Data collection was completed between the period from Oct 2013 to Feb 2014. Patients and Methods: The sample was selected using non- probability sampling technique. Collected breast cancer patients sample was n= 311 whose age range was from 18-80 years. A biographical sheet that contain personal and disease information of patient, and two scales were used: Self Report Measure of Emotional Intelligence (Khan and Kamal, 2010), and Multidimensional Health Locus of Control (Wallston, Stein, and Smith, 1994) were used to assess the constructs explored in this study. Results: Results depict that there was significant positive correlation between emotional intelligence (EI), including its sub scales Emotional Self-Regulation Skills (ESRS), Emotional Self Awareness Skills (ESAS), and Interpersonal Skills Scale (ISS) with the Internal Health Locus of Control (IHLOC). Doctors Health Locus of Control (DHLOC) also have significant relationship to emotional intelligence's all sub divisions, whereas external health locus of control including Chance Health Locus of Control (CHLOC) and Powerful Other people Health Locus of Control (PHLOC) both are related to psychological distresses but it was observed in breast cancer population that chance was significantly correlated to ESAS, and ISS and powerful other people locus. Further on group comparison One Way Analysis of Variance (ANOVA) depicted no significant difference on disease stage groups. Conclusion: The strength factors of EI and HLOC are highlighted in current study. It was concluded that Emotional Intelligence (EI) and health locus of control (IHLOC

  14. Optic nerve invasion of uveal melanoma

    DEFF Research Database (Denmark)

    Lindegaard, Jens; Isager, Peter; Prause, Jan Ulrik

    2007-01-01

    The aim of the study was to identify the histopathological characteristics associated with the invasion of the optic nerve of uveal melanoma and to evaluate the association between invasion of the optic nerve and survival. In order to achieve this, all uveal melanomas with optic nerve invasion...... in Denmark between 1942 and 2001 were reviewed (n=157). Histopathological characteristics and depth of optic nerve invasion were recorded. The material was compared with a control material from the same period consisting of 85 cases randomly drawn from all choroidal/ciliary body melanomas without optic nerve...... invasion. Prelaminar/laminar optic nerve invasion was in multivariate analysis associated with focal retinal invasion, neovascularization of the chamber angle, and scleral invasion. Postlaminar invasion was further associated with non-spindle cell type and rupture of the inner limiting membrane...

  15. [Illness concepts of children. Validation of a modified locus of control test in illness and health].

    Science.gov (United States)

    Schmidt, A; Altmann-Herz, U

    1992-12-01

    We investigated the health and illness concepts of 53 healthy children aged 8 to 14 years using a modified illness and health locus of control scale (KKG, Lohaus and Schmitt, 1989) with the scales internal, external-p (powerful others) and external-c (chance). A comparison of the results with those on self-esteem (FSK 4-6), anxiety (CMAS-R) and hopelessness (HSC) scales showed a decrease in externality, but not an increase in internality, with increasing age and a correlation between self-confidence and a more internal locus of control. The influence of children's health locus of control on treatment compliance is discussed.

  16. Personal networks and locus of control in large urban centers of Argentina

    Directory of Open Access Journals (Sweden)

    Pablo De Grande

    2013-12-01

    Full Text Available This study analyzes the relationship between locus of control and interpersonal relations structures in Argentina. After a representative sample (n = 1500 of households in seven major urban centers (>200,000 inhabitants, it examines the relationship between the externality of locus of control and different aspects of personal networks of each respondent. The results show that people having more relations experiment lower levels of externality of locus of control. Likewise, lower levels of externality are informed when personal ties outside the neighborhood are available, as well as ties high educational level. In this regard, significant associations are verified between control and personal relations structures.

  17. Invasive exotic plants suffer less herbivory than non-invasive exotic plants

    OpenAIRE

    Cappuccino, Naomi; Carpenter, David

    2005-01-01

    We surveyed naturally occurring leaf herbivory in nine invasive and nine non-invasive exotic plant species sampled in natural areas in Ontario, New York and Massachusetts, and found that invasive plants experienced, on average, 96% less leaf damage than non-invasive species. Invasive plants were also more taxonomically isolated than non-invasive plants, belonging to families with 75% fewer native North American genera. However, the relationship between taxonomic isolation at the family level ...

  18. Molecular studies of deletions at the human steroid sulfatase locus

    Energy Technology Data Exchange (ETDEWEB)

    Shapiro, L.J.; Yen, P.; Pomerantz, D.; Martin, E.; Rolewic, L.; Mohandas, T. (Univ. of California, Los Angeles (USA))

    1989-11-01

    The human steroid sulfatase gene (STS) is located on the distal X chromosome short arm close to the pseudoautosomal region but in a segment of DNA that is unique to the X chromosome. In contrast to most X chromosome-encoded genes, STS expression is not extinguished during the process of X chromosome inactivation. Deficiency of STS activity produced the syndrome of X chromosome-linked ichthyosis, which is one of the most common inborn errors of metabolism in man. Approximately 90% of STS{sup {minus}} individuals have large deletions at the STS locus. The authors and others have found that the end points of such deletions are heterogeneous in their location. One recently ascertained subject was observed to have a 40-kilobase deletion that is entirely intragenic, permitting the cloning and sequencing of the deletion junction. Studies of this patient and of other X chromosome sequences in other subjects permit some insight into the mechanism(s) responsible for generating frequent deletions on the short arm of the X chromosome.

  19. Locus coeruleus and dopaminergic consolidation of everyday memory

    Science.gov (United States)

    Takeuchi, Tomonori; Duszkiewicz, Adrian J.; Sonneborn, Alex; Spooner, Patrick A.; Yamasaki, Miwako; Watanabe, Masahiko; Smith, Caroline C.; Fernández, Guillén; Deisseroth, Karl; Greene, Robert W.; Morris, Richard G. M.

    2016-01-01

    Summary The retention of episodic-like memory is enhanced, in humans and animals, when something novel happens shortly before or after encoding. Using an everyday memory task in mice, we sought the neurons mediating this dopamine-dependent novelty effect, previously thought to originate exclusively from the tyrosine hydroxylase-expressing (TH+) neurons in the ventral tegmental area (VTA). We report that neuronal firing in the locus coeruleus (LC) is especially sensitive to environmental novelty, LC-TH+ neurons project more profusely than VTA-TH+ neurons to the hippocampus, optogenetic activation of LC-TH+ neurons mimics the novelty effect, and this novelty-associated memory enhancement is unaffected by VTA inactivation. Surprisingly, two effects of LC-TH+ photoactivation are sensitive to hippocampal D1/D5 receptor blockade and resistant to adrenoceptors blockade – memory enhancement and long lasting potentiation of synaptic transmission in CA1 ex vivo. Thus, LC-TH+ neurons can mediate post-encoding memory enhancement in a manner consistent with possible co-release of dopamine in hippocampus. PMID:27602521

  20. Adenylate kinase locus 1 polymorphism and feto-placental development.

    Science.gov (United States)

    Fulvia, Gloria-Bottini; Antonio, Pietroiusti; Anna, Neri; Patrizia, Saccucci; Ada, Amante; Egidio, Bottini; Andrea, Magrini

    2011-12-01

    Recently our group has found that the correlation between birth weight and placental weight - an index of a balanced feto-placental unit development - is influenced by genetic factors. Since adenylate kinase locus 1 (AK₁) is a polymorphic enzyme that plays an important role in the synthesis of nucleotides required for many metabolic functions, we have investigated the possible role of its genetic variability in the correlation between birth weight and placental weight. 342 consecutive healthy newborn infants from the population of Rome (Italy) and 286 puerperae from another population from Central Italy were studied. The correlation coefficient between birth weight and placental weight is much higher in infants with low activity AK₁2-1 phenotype than in those with high activity AK₁1 phenotype. The difference between AK₁ and AK₁2-1 is well marked only in newborns with a gestational age greater than 38 weeks and it is not influenced by sex, maternal age and maternal smoking. A similar pattern is observed with maternal AK₁ phenotype. These results suggest that the difference in enzymatic activity between AK₁ phenotypes influencing the equilibrium among ATP, ADP, AMP and adenosine could have an important role in a balanced development of feto-placental unit. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  1. Characterization of mutations at the mouse phenylalanine hydroxylase locus

    Energy Technology Data Exchange (ETDEWEB)

    McDonald, J.D.; Charlton, C.K. [Wichita State Univ., KS (United States)

    1997-02-01

    Two genetic mouse models for human phenylketonuria have been characterized by DNA sequence analysis. For each, a distinct mutation was identified within the protein coding sequence of the phenylalanine hydroxylase gene. This establishes that the mutated locus is the same as that causing human phenylketonuria and allows a comparison between these mouse phenylketonuria models and the human disease. A genotype/phenotype relationship that is strikingly similar to the human disease emerges, underscoring the similarity of phenylketonuria in mouse and man. In PAH{sup ENU1}, the phenotype is mild. The Pah{sup enu1} mutation predicts a conservative valine to alanine amino acid substitution and is located in exon 3, a gene region where serious mutations are rare in humans. In PAH{sup ENU2} the phenotype is severe. The Pah{sup enu2} mutation predicts a radical phenylalanine to serine substitution and is located in exon 7, a gene region where serious mutations are common in humans. In PAH{sup ENU2}, the sequence information was used to devise a direct genotyping system based on the creation of a new Alw26I restriction endonuclease site. 26 refs., 2 figs., 1 tab.

  2. Modulation of locus coeruleus activity by novel oddball stimuli.

    Science.gov (United States)

    Krebs, Ruth M; Park, Haeme R P; Bombeke, Klaas; Boehler, Carsten N

    2018-04-01

    It has long been known from animal literature that the locus coeruleus (LC), the source region of noradrenergic neurons in the brain, is sensitive to unexpected, novel, and other salient events. In humans, however, direct assessment of LC activity has proven to be challenging due to its small size and difficult localization, which is why noradrenergic activity has often been assessed using more indirect measures such as electroencephalography (EEG) and pupil recordings. Here, we combined high-resolution functional magnetic resonance imaging (fMRI) with a special anatomical sequence to assess neural activity in the LC in response to different types of salient stimuli in an oddball paradigm (novel neutral oddballs, novel emotional oddballs, and familiar target oddballs). We found a significant linear increase of LC activity from standard trials, over familiar target oddballs, to novel neutral and novel emotional oddballs. Importantly, when breaking down this linear trend, only novel oddball stimuli led to robust activity increases as compared to standard trials, with no statistical difference between neutral and emotional ones. This pattern suggests that activity modulations in the LC in the present study were mainly driven by stimulus novelty, rather than by emotional saliency, task relevance, or contextual novelty alone. Moreover, the absence of significant activity modulations in response to target oddballs (which were reported in a recent study) suggests that the LC represents relative rather than absolute saliency of a stimulus in its respective context.

  3. Molecular studies of deletions at the human steroid sulfatase locus

    International Nuclear Information System (INIS)

    Shapiro, L.J.; Yen, P.; Pomerantz, D.; Martin, E.; Rolewic, L.; Mohandas, T.

    1989-01-01

    The human steroid sulfatase gene (STS) is located on the distal X chromosome short arm close to the pseudoautosomal region but in a segment of DNA that is unique to the X chromosome. In contrast to most X chromosome-encoded genes, STS expression is not extinguished during the process of X chromosome inactivation. Deficiency of STS activity produced the syndrome of X chromosome-linked ichthyosis, which is one of the most common inborn errors of metabolism in man. Approximately 90% of STS - individuals have large deletions at the STS locus. The authors and others have found that the end points of such deletions are heterogeneous in their location. One recently ascertained subject was observed to have a 40-kilobase deletion that is entirely intragenic, permitting the cloning and sequencing of the deletion junction. Studies of this patient and of other X chromosome sequences in other subjects permit some insight into the mechanism(s) responsible for generating frequent deletions on the short arm of the X chromosome

  4. Polarized gene conversion at the bz locus of maize.

    Science.gov (United States)

    Dooner, Hugo K; He, Limei

    2014-09-23

    Nucleotide diversity is greater in maize than in most organisms studied to date, so allelic pairs in a hybrid tend to be highly polymorphic. Most recombination events between such pairs of maize polymorphic alleles are crossovers. However, intragenic recombination events not associated with flanking marker exchange, corresponding to noncrossover gene conversions, predominate between alleles derived from the same progenitor. In these dimorphic heterozygotes, the two alleles differ only at the two mutant sites between which recombination is being measured. To investigate whether gene conversion at the bz locus is polarized, two large diallel crossing matrices involving mutant sites spread across the bz gene were performed and more than 2,500 intragenic recombinants were scored. In both diallels, around 90% of recombinants could be accounted for by gene conversion. Furthermore, conversion exhibited a striking polarity, with sites located within 150 bp of the start and stop codons converting more frequently than sites located in the middle of the gene. The implications of these findings are discussed with reference to recent data from genome-wide studies in other plants.

  5. ABO locus O1 allele and risk of myocardial infarction.

    Science.gov (United States)

    von Beckerath, Nicolas; Koch, Werner; Mehilli, Julinda; Gorchakova, Olga; Braun, Siegmund; Schömig, Albert; Kastrati, Adnan

    2004-01-01

    An association between ABO blood group and myocardial infarction (MI) has been described. One probable mechanism underlying this association is the influence of ABO blood group on plasma von Willebrand factor (vWF) levels. We conducted this genetic study to test whether the ABO O1 allele is associated with low vWF plasma levels and with a reduced risk of MI. Cases consisted of 793 consecutive, angiographically examined patients with either acute or prior MI. As controls served 340 angiographically examined patients with neither coronary artery disease nor signs of MI. ABO1 locus alleles (A1, A2, B, O1, O2) were identified with polymerase chain reaction and fluorogenic probes. The distribution of O1 alleles in the MI group versus the control group was: no O1 allele (15.4%/10.0%), one O1 allele (49.7%/50.0%) and two O1 alleles (34.9%/40.0%) (P = 0.035). O1 allele carriage was associated with a 39% reduction in the risk of MI unadjusted odds ratio, 0.61; 95% confidence interval, 0.41-0.91). The significant association was maintained after adjustment for other cardiovascular risk factors. vWF antigen levels correlated with the number of O1 alleles (P = 0.00003) in a separate control group (n = 164). Carriage of the O1 allele is associated with a decreased risk of myocardial infarction, with homozygosity providing the greatest protection. Copyright 2004 Lippincott Williams and Wilkins

  6. Rapid multi-locus sequence typing using microfluidic biochips.

    Directory of Open Access Journals (Sweden)

    Timothy D Read

    2010-05-01

    Full Text Available Multiple locus sequence typing (MLST has become a central genotyping strategy for analysis of bacterial populations. The scheme involves de novo sequencing of 6-8 housekeeping loci to assign unique sequence types. In this work we adapted MLST to a rapid microfluidics platform in order to enhance speed and reduce laboratory labor time.Using two integrated microfluidic devices, DNA was purified from 100 Bacillus cereus soil isolates, used as a template for multiplex amplification of 7 loci and sequenced on forward and reverse strands. The time on instrument from loading genomic DNA to generation of electropherograms was only 1.5 hours. We obtained full-length sequence of all seven MLST alleles from 84 representing 46 different Sequence Types. At least one allele could be sequenced from a further 15 strains. The nucleotide diversity of B. cereus isolated in this study from one location in Rockville, Maryland (0.04 substitutions per site was found to be as great as the global collection of isolates.Biogeographical investigation of pathogens is only one of a panoply of possible applications of microfluidics based MLST; others include microbiologic forensics, biothreat identification, and rapid characterization of human clinical samples.

  7. Non-invasive mechanical ventilation

    African Journals Online (AJOL)

    Nicky

    failure may benefit from a trial of NIV. Increased work of breathing, as noted by use of accessory breathing. SAJCC. 10. July 2005, V ol. 21, No. 1. University of Manitoba and Manitoba Institute of Child Health, Winnipeg, Canada. B Louise Giles, MD, FRCPC. Non-invasive ventilation (NIV) is a modality of providing airway and ...

  8. Vaccines against invasive Salmonella disease

    Science.gov (United States)

    MacLennan, Calman A; Martin, Laura B; Micoli, Francesca

    2014-01-01

    Though primarily enteric pathogens, Salmonellae are responsible for a considerable yet under-appreciated global burden of invasive disease. In South and South-East Asia, this manifests as enteric fever caused by serovars Typhi and Paratyphi A. In sub-Saharan Africa, a similar disease burden results from invasive nontyphoidal Salmonellae, principally serovars Typhimurium and Enteritidis. The existing Ty21a live-attenuated and Vi capsular polysaccharide vaccines target S. Typhi and are not effective in young children where the burden of invasive Salmonella disease is highest. After years of lack of investment in new Salmonella vaccines, recent times have seen increased interest in the area led by emerging-market manufacturers, global health vaccine institutes and academic partners. New glycoconjugate vaccines against S. Typhi are becoming available with similar vaccines against other invasive serovars in development. With other new vaccines under investigation, including live-attenuated, protein-based and GMMA vaccines, now is an exciting time for the Salmonella vaccine field. PMID:24804797

  9. Invasive cranial mycosis our experiences

    Directory of Open Access Journals (Sweden)

    Tapas Kumbhkar

    2013-01-01

    Full Text Available Fungi can cause serious cranial infections in immunocompromised and diabetic patients. Common pathogens mainly include Aspergillus and Mucor. These organisms cause tissue invasion and destruction of adjacent structures (e.g. orbit, ethmoid, sphenoid, maxillary & cavernous sinuses. Mortality and morbidity rate is high despite combined surgical, antifungal and antidiabetic treatment. We present our experience of six cases with such infection.

  10. Biological invasions in forest ecosystems

    Science.gov (United States)

    Andrew M. Liebhold; Eckehard G. Brockerhoff; Susan Kalisz; Martin A. Nuñez; David A. Wardle; Michael J. Wingfield

    2017-01-01

    Forests play critical roles in global ecosystem processes and provide numerous services to society. But forests are increasingly affected by a variety of human influences, especially those resulting from biological invasions. Species invading forests include woody and herbaceous plants, many animal species including mammals and invertebrates, as well as a variety of...

  11. Analysis of the rat Iddm14 diabetes susceptibility locus in multiple rat strains: identification of a susceptibility haplotype in the Tcrb-V locus

    OpenAIRE

    Mordes, John P.; Cort, Laura; Norowski, Elaine; Leif, Jean; Fuller, Jessica M.; Lernmark, Åke; Greiner, Dale L.; Blankenhorn, Elizabeth P.

    2009-01-01

    Iddm14 (formerly Iddm4) is a non-MHC-linked genetic locus associated with autoimmune diabetes. Its effects have been well-documented in BB-derived rats in which diabetes is either induced by immunologic perturbation or occurs spontaneously. The role of Iddm14 in non-BB rat strains is unknown. Our goal was to extend the analysis of Iddm14 in new diabetes-susceptible strains and to identify candidate genes in the rat Iddm14 diabetes susceptibility locus that are common to these multiple diabeti...

  12. Vocational interests of adolescents: relationships between self-esteem and locus of control.

    Science.gov (United States)

    Mullis, A K; Mullis, R L

    1997-12-01

    The purpose of this study was to examine relationships among scores on vocational interests, self-esteem, and locus of control for high school students. Grade and sex differences were also examined. 1364 high school students ranging in age from 14 to 19 years of age were administered the Coopersmith Self-esteem Inventory, Nowicki-Strickland Locus of Control Scale for Children, and the Strong-Campbell Interest Inventory. High school students with higher scores on self-esteem and showing an orientation toward internal locus of control expressed more interests in a variety of vocational themes than adolescents with lower scores on self-esteem and scores for external locus of control. Sex and grade differences in vocational interests of adolescents were also noted. The findings were discussed in light of theoretical and practical considerations.

  13. [Locus of control and self-concept in interpersonal conflict resolution approaches].

    Science.gov (United States)

    Hisli Sahin, Nesrin; Basim, H Nejat; Cetin, Fatih

    2009-01-01

    The purpose of this study was to investigate the relationship between self-concept and locus of control in interpersonal conflict resolution approaches and to determine the predictors of conflict resolution approach choices. The study included 345 students aged between 18 and 28 years that were studying at universities in Ankara. Data were collected using the Interpersonal Conflict Resolution Approaches Scale to measure conflict resolution approaches, the Social Comparison Scale to measure self-concept, and the Internal-External Locus of Control Scale to measure locus of control. It was observed that confrontation approach to interpersonal conflict was predicted by self-concept (beta = 0.396, P interpersonal conflict resolution process. Individuals with a positive self-concept and an internal locus of control adopted solutions to interpersonal conflict resolution that were more effective and constructive.

  14. Triatominae et Cactaceae : un risque pour la transmission de la Trypanosomose américaine dans le péridomicile (nord-est du Brésil

    Directory of Open Access Journals (Sweden)

    Emperaire L.

    2006-06-01

    Full Text Available Les observations de terrain réalisées dans le nord-est du Brésil ont montré la fréquente association, dans l’espace péridomiciliaire, entre un cactus, le Cereus jamacaru, la présence de nids dans ses branches et celle de Rhodnius neglectus et de Triatoma pseudomaculata, espèces vectrices du parasite Trypanosoma cruzi, agent de la maladie de Chagas. L’analyse des variables architecturales de cette Cactaceae montre que la présence de nids, et donc d’insectes, est inféodée aux pratiques traditionnelles de gestion de ce cactus. Cette étude souligne l’intérêt d’une approche intégrée de l’écologie des Triatominae pour l’identification des variables indicatrices de risque.

  15. Transferts culturels et passeurs de culture dans le monde du livre (France - Brésil, XIX siècle) / Cultural Transfers and Cultural Mediators of the Literary World: France and Brazil in the 19th Century

    OpenAIRE

    COOPER-RICHET, Diana

    2013-01-01

    Grâce à des concepts nouveaux, tels que ceux de transfert et de passeur, les échanges culturels entre la France et le Brésil au XIX siècle, peuvent désormais être revisités au prisme de l’histoire des imprimés. La circulation, d’un côté à l’autre de l’Atlantique, de livres et de périodiques, en français et en portugais, le rôle joué par un certain nombre de libraires-éditeurs parisiens dans la production et dans la diffusion de ces ouvrages sont révélateurs de la place occupée par Paris dans ...

  16. Desempenho de escolares com dislexia do desenvolvimento em tarefas fonológicas e silábicas Performance of students with developmental dyslexia in phonological and syllabic tasks

    Directory of Open Access Journals (Sweden)

    Giseli Donadon Germano

    2009-06-01

    Full Text Available OBJETIVO: caracterizar o desempenho em tarefas fonológicas e silábicas de escolares com dislexia do desenvolvimento e comparar estes achados com o desempenho de discentes com bom desempenho escolar. MÉTODOS: participaram do estudo 26 alunos de oito a 12 anos de idade, de ambos os sexos, de 2ª. a 4ª. séries do Ensino Fundamental municipal na cidade de Marilia-SP, divididas em GI: composto por 13 escolares com dislexia atendidos no Centro de Estudos da Educação e Saúde - CEES/UNESP e GII: composto por 13 alunos com bom desempenho acadêmico, pareados segundo sexo, idade e escolaridade com o GI. Como procedimento foi utilizada a Prova de Consciência Fonológica - Instrumento de Avaliação Seqüencial - CONFIAS. Os resultados foram analisados estatisticamente pelo Teste Mann-Whitney (comparação entre os grupos e Teste dos Postos Sinalizados-Wilcoxon (comparação entre as variáveis. RESULTADOS: os resultados evidenciaram diferença estatisticamente significante, sugerindo melhor desempenho do GII em relação ao GI quanto às tarefas fonêmicas e silábicas. O GI apresentou diferença estatisticamente significativa nas tarefas silábicas e fonêmicas, com melhor desempenho nas primeiras. Entre os escolares do GII não houve grande diferença estatística entre tarefas silábicas, apenas entre tarefas fonêmicas. CONCLUSÃO: o estudo concluiu que escolares com dislexia do desenvolvimento apresentam dificuldades quanto à identificação de rima e produção de palavras com o som dado, apontando para um déficit em acessar os códigos e as representações fonológicas.PURPOSE: to characterize and to compare the performance in phonological and syllabic tasks of developmental dyslexia to good readers. METHODS: twenty-six students participated, with age varying between 8 and 12 years, both genders, of 2nd and 4th grades of the municipal elementary education of the city of Marília-SP. They were divided into GI: 13 developmental dyslexic

  17. Quantificação da ferrugem asiática e aspectos nutricionais de soja suprida com silício em solução nutritiva

    OpenAIRE

    Lima,Luciana Maria de; Pozza,Edson Ampélio; Pozza,Adélia Aziz Alexandre; Fonseca,Thiago Antônio de Pádua Silva; Carvalho,Janice Guedes de

    2010-01-01

    Para quantificar a severidade da ferrugem, os teores de clorofilas a e b e os carotenóides e também a nutrição em plantas de soja supridas com silício, implantou-se um experimento em blocos casualizados com 6 tratamentos e 4 repetições. Os tratamentos consistiram em doses de silicato de potássio (0 mg/L, 56 mg/L, 112 mg/L, 168 mg/L, 224 mg/L e 280 mg/L). As plantas foram inoculadas no estádio V4. Nove dias após a inoculação, iniciaram-se as avaliações semanais do número de lesões de ferrugem ...

  18. Influência do hipoclorito de sódio como fungicida na absorção de cálcio e silício pela soja

    OpenAIRE

    Resende, Anselmo; Souza, Jurandir Rodrigues de; Souza, Plínio Itamar de Mello de; Blum, Luiz Eduardo Bassay

    2009-01-01

    O objetivo da pesquisa foi verificar a ação do hipoclorito de sódio (NaOCl) no combate ao oídio na soja, quando aplicado só ou associado ao uso de fungicida, e a possível influência na absorção de cálcio e silício pela soja. Foram realizadas oito aplicações de NaOCl em parcelas que receberam apenas o sanitizante, com concentrações de 0,2%, 0,4% e 0,6%, parcelas que receberam essas mesmas concentrações e duas aplicações de fungicida e uma parcela controle. Não foram observadas diferenças es...

  19. Conflits et organisation de l’espace public dans les processus décisionnaires en France et au Brésil: la négociation d’aires protégées

    OpenAIRE

    Tilbeurgh, Véronique Van; Costa, Guilherme Borges da

    2016-01-01

    L´objectif de cet article est d’interroger le lien entre le conflit et l’organisation de l’espace public dans les processus de négociation d’une décision publique. Nous comparons les négociations dans deux zones protégées, le parc marin en mer d’Iroise (en France) et l´aire protégée Várzea do Rio Tietê (au Brésil). Cette comparaison montre que dans les deux cas, la décision devant être négociée a été imposée par une des parties, mais cette situation n’a eu un effet amplificateur du conflit qu...

  20. Health locus of control: Its relationship with medication adherence and medication wastage.

    Science.gov (United States)

    West, Lorna Marie; Borg Theuma, Ruth; Cordina, Maria

    2017-12-09

    Non-adherence is a significant factor contributing to medication wastage. Whilst there is some evidence on the influence of patients' health locus of control in relation to adherence, there has been little inquiry into its relationship with mediation wastage. To determine the relationship between medication adherence and health locus of control as well as medication wastage and health locus of control in patients with chronic conditions. Outpatients having a diagnosis of asthma, cardiovascular conditions, or diabetes participated in a cross-sectional study employing a self-administered questionnaire. The questionnaire determined presence of unused medication (wastage), adherence using 'Tool for Adherence Behaviour Screening' (TABS), and health locus of control using 'Multidimensional Health Locus of Control' (MHLC) scale Form C. Logistic regression was performed to ascertain the effects of MHLC and demographics in relation to adherence and wastage. MHLC beliefs were divided into 8 types of health locus of control. One-Way ANOVA was used to assess differences between conditions and belief types. P-values ≤ .05 were considered significant. There were 330 patients recruited (58% male; age, mean±(SD): 61 ± 15 years; 110 asthma, 110 cardiovascular, 110 diabetes). In terms of health locus of control, females had higher 'doctors' beliefs (p = .054) and significantly lower 'other people' beliefs (p = control. 'Yea-sayers' had the least presence of unused medication, followed by 'pure internal' believers. 'Pure powerful others external' had the highest presence of unused medication. Healthcare professionals should take into account patients' health locus of control beliefs whilst conducting an intervention with patients; this can impact positively medication adherence and minimisation of medication wastage. Copyright © 2017 Elsevier Inc. All rights reserved.

  1. Adult self-esteem and locus of control as a function of familial alcoholism and dysfunction.

    Science.gov (United States)

    Werner, L J; Broida, J P

    1991-05-01

    This study examines self-esteem and locus of control in adult children of alcoholics. We assessed these measures in 195 professional adults in relation to alcoholism and functioning in the family of origin. Although the presence of parental alcoholism was not a predictor of significant differences in adult self-esteem or locus of control, familial dysfunction was reflected in significant differences in self-esteem. This suggests that parental alcoholism does not necessarily result in personality differences in adult children.

  2. The effect of high and low assertiveness on locus of control and health problems.

    Science.gov (United States)

    Williams, J M; Stout, J K

    1985-03-01

    The effect of high and low assertiveness on locus of control and health problems was examined with 78 direct-service workers in mental health and mental retardation settings in northeastern Pennsylvania. The direct-service workers completed the Rathus (1973) Assertiveness Schedule, the Rotter (1966) Internal-External Locus of Control Scale, and a health-problems inventory. Highly assertive individuals were found to be more internally controlled and to experience fewer health problems than were individuals low in assertiveness.

  3. The Interrelationship among Locus of Control, Sexual Satisfaction and Marital Satisfaction

    OpenAIRE

    Askari Asgharianji; Kamo Vardanyan; Shokouh Navabinejad

    2015-01-01

    The primary goal of the present study is to examine the interrelationships among locus of control, sexual satisfaction and marital satisfaction. In the current study, a sample which was composed of 200 married persons was investigated. Research tools include locus of control, sexual satisfaction and marital satisfaction. For data analysis, correlation and independent hierarchical multiple regression analyses were used to determine the relationships between the predictor variables and criterio...

  4. Relationship between Dental Anxiety and Health Locus of Control among Physiotherapy Students

    Directory of Open Access Journals (Sweden)

    Pooja Agarwal

    2013-01-01

    Materials & Method: A total of 152 students participated in the study. Dental anxiety was assessed using the 5 item Modified Dental Anxiety Scale (MDAS and Locus of Control was assessed using the 18 item Multidimensional Health Locus of Control (MHLC scale. Results: A Statistically significant positive correlation was found between the internal dimension of MHLC and dental anxiety. Conclusions: HLC was found to play an important role in predicting the dental anxiety among physiotherapy students.

  5. Approaching invasive species in Madagascar | Kull | Madagascar ...

    African Journals Online (AJOL)

    invasive', the topic of invasive species has until recently received less attention here than in other island contexts. Some species, often alien to Madagascar and introduced by humans, have expanded their range rapidly and have had both ...

  6. Invasive thymoma: CT diagnosis and evaluation

    International Nuclear Information System (INIS)

    Sun Zhonghua; Yu Hong; Liu Hengshun; Yan Hongzhen; Zhang Shurong

    1998-01-01

    Purpose: To study the CT manifestation of invasive thymoma for staging and treatment planning. Materials and methods: The authors reviewed and analyzed the CT scans of 26 patients with invasive thymoma confirmed by surgery and pathology with emphasis on lesion density, invasion of adjacent mediastinal structures, pleural seeding mediastinal nodes and extra-mediastinal metastases. Results: In 26 cases of invasive thymoma, all CT scans demonstrated the soft tissue mass in anterior mediastinum, with heterogeneous density in 16 patients. Irregular invasion to adjacent organs was found in 24 patients. The main findings were mediastinal pleura invasion in 7, lung invasion 9, pleural implants 3, cardiovascular involvement in 20, and cardiophrenic and abdominal invasion in 3. CT is especially effective in detecting the involvement of pleura, pericardium and lung. Conclusion: Computed tomography provides the most reliable assessment of the extent of the disease. Conventional CT scan allows accurate staging and treatment planning

  7. Comparing health locus of control in patients with Spasmodic Dysphonia, Functional Dysphonia and Nonlaryngeal Dystonia.

    Science.gov (United States)

    Haselden, Karen; Powell, Theresa; Drinnan, Mike; Carding, Paul

    2009-11-01

    Locus of Control (LoC) refers to an individuals' perception of whether they are in control of life events. Health Locus of Control refers to whether someone feels they have influence over their health. Health Locus of Control has not been studied in any depth in voice-disordered patients. The objective of this study was to examine Health Locus of Control in three patient groups: (1) Spasmodic Dysphonia, (2) Functional Dysphonia and (3) a nondysphonic group with Nonlaryngeal Dystonia. LoC was measured and compared in a total of 57 patients using the Multidimensional Health Locus of Control Scales (diagnostic specific) Form C. Internal, Chance, and Powerful others LoC were measured and comparisons were made using one-way analysis of variance. Contrary to expectations Internal LoC was found to be significantly higher in the Functional Dysphonia group when compared to the other two groups. There was no significant difference between the groups in Chance or Powerful others LoC. The two organic groups, Spasmodic Dysphonia and Nonlaryngeal Dystonia, were more alike in Internal Health Locus of Control than the Functional Dysphonia group. The diagnostic nature of the groups was reflected in their LoC scores rather than their voice loss. These results contribute to the debate about the etiology of Spasmodic Dysphonia and will be of interest to those involved in the psychology of voice and those managing voice-disordered patients.

  8. Locus of control and peer relationships among Caucasian, Hispanic, Asian, and African American adolescents.

    Science.gov (United States)

    Kang, Hannah Soo; Chang, Kyle Edward; Chen, Chuansheng; Greenberger, Ellen

    2015-01-01

    Past research has shown that locus of control plays an important role in a wide range of behaviors, such as academic achievement and positive social behaviors. However, little is known about whether locus of control plays the same role in minority adolescents' peer relationships. The current study examined ethnic differences in the associations between locus of control and peer relationships in early adolescence using samples from the Early Childhood Longitudinal Study (ECLS-K: 5,612 Caucasian, 1,562 Hispanic, 507 Asian, and 908 African-American adolescents) and the National Education Longitudinal Study (NELS: 8,484 Caucasian, 1,604 Hispanic, and 860 Asian, and 1,228 African American adolescents). Gender was approximately evenly split in both samples. The results from the two datasets were highly consistent. Significant interactions between ethnicity and locus of control indicated that having a more internal locus of control was particularly important for Caucasian students' peer relationships (ECLS-K) and social status (NELS), but less so for Asian, Hispanic, and African American students. Our findings suggest that the role of locus of control in peer relationship is contingent upon culture.

  9. Social capital, political trust, and health locus of control: a population-based study.

    Science.gov (United States)

    Lindström, Martin

    2011-02-01

    To investigate the association between political trust in the Riksdag and lack of belief in the possibility to influence one's own health (external locus of control), taking horizontal trust into account. The 2008 public health survey in Skåne is a cross-sectional postal questionnaire study with a 55% participation rate. A random sample of 28,198 persons aged 18-80 years participated. Logistic regression models were used to investigate the associations between political trust in the Riksdag (an aspect of vertical trust) and lack of belief in the possibility to influence one's own health (external locus of control). The multiple regression analyses included age, country of birth, education, and horizontal trust in other people. A 33.7% of all men and 31.8% of all women lack internal locus of control. Low (external) health locus of control is more common in higher age groups, among people born outside Sweden, with lower education, low horizontal trust, low political trust, and no opinion concerning political trust. Respondents with not particularly strong political trust, no political trust at all and no opinion have significantly higher odds ratios of external locus of control throughout the multiple regression analyses. Low political trust in the Riksdag seems to be independently associated with external health locus of control.

  10. PENGARUH LOCUS OF CONTROL DAN HARGA DIRI TERHADAP MOTIVASI KERJA PEGAWAI DINAS PENDIDIKAN KOTA MEDAN

    Directory of Open Access Journals (Sweden)

    Masrul Badri

    2017-08-01

    Full Text Available This study aims to see the effect of locus of control and dignity of the employee work motivation Medan City Department of Education. Based on the existing theoretical framework, namely by Burns (2004 states that individuals are not easily affected by external environment of an individual who himself is having internal Locus Of Controln   Then the proposed hypothesis: 1. There is the influence of Locus of control and self-esteem together on employee motivation employee Education Department. 2. There is the influence of self-esteem of employee motivation. 3. There is the influence of locus of control on employee motivation. In proving the above hypothesis, we used data analysis methods, namely Multiple Regression Analysis.. Based on these results, the hypothesis proposed been accepted. 2 As for the contribution of the variable influence of self-esteem on the work motivation of employees by 29%. 3. Effect of locus of control on employee motivation to work in Medan City Government Department of Education with a contribution of 47%. The total effective contribution of these two independent variables (locus of control and self-esteem on the performance of employees is 76% From the results it is known that there is still a 24% influence of other factors of motivation to work is not examined in this study.

  11. Prevalence of Porphyromonas gingivalis Four rag Locus Genotypes in Patients of Orthodontic Gingivitis and Periodontitis

    Science.gov (United States)

    Liu, Yi; Zhang, Yujie; Wang, Lili; Guo, Yang; Xiao, Shuiqing

    2013-01-01

    Porphyromonas gingivalis is considered as a major etiological agent in periodontal diseases and implied to result in gingival inflammation under orthodontic appliance. rag locus is a pathogenicity island found in Porphyromonas gingivalis. Four rag locus variants are different in pathogenicity of Porphyromonas gingivalis. Moreover, there are different racial and geographic differences in distribution of rag locus genotypes. In this study, we assessed the prevalence of Porphyromonas gingivalis and rag locus genotypes in 102 gingival crevicular fluid samples from 57 cases of gingivitis patients with orthodontic appliances, 25 cases of periodontitis patients and 20 cases of periodontally healthy people through a 16S rRNA-based PCR and a multiplex PCR. The correlations between Porphyromona.gingivalis/rag locus and clinical indices were analyzed. The prevalence of Porphyromonas gingivalis and rag locus genes in periodontitis group was the highest among three groups and higher in orthodontic gingivitis than healthy people (porthodontic gingivitis and mild-to-moderate periodontitis in Shandong. Porphyromonas.gingivalis carrying rag-1 has the strong virulence and could be associated with severe periodontitis. PMID:23593379

  12. Physical map and one-megabase sequencing of the human immunoglobulin lambda locus

    Directory of Open Access Journals (Sweden)

    Geraldo A.S. Passos Jr.

    1998-06-01

    Full Text Available The human immunoglobulin lambda (IGL locus is located on chromosome 22q11.1-q11.2 and contains the genes responsible for the immunoglobulin lambda light chains. This locus was recently mapped (physical map and its 1-Mb DNA totally sequenced. In this review we focus on the characterization of the v-lambda genes, its chromosomal location, genomics and sequencing of the IGL locus.O locus IGL humano está localizado no cromosomo 22q11.1-q11.2 e contém os genes responsáveis pelas cadeias leves de imunoglobulina tipo lambda. Este locus foi recentemente mapeado (mapa físico e seu 1 Mb DNA totalmente sequenciado. Nesta revisão focamos os principais resultados de caracterização dos genes v-lambda, sua localização cromossômica, a genômica e seqüenciamento do locus IGL.

  13. Influence of silicon on the development, productivity and infestation by insect pests in potato crops Influência de silício no desenvolvimento de batateiras e na ocorrência de insetos-praga

    Directory of Open Access Journals (Sweden)

    Valkíria Fabiana da Silva

    2010-12-01

    Full Text Available Potato crops are susceptible to various insect pests including the aphid Myzus persicae (Hemiptera, Aphididae and the beetle Diabrotica speciosa (Coleoptera, Chrysomelidae. Induced resistance through silicon treatment of plants represents a potential strategy in pest management. The objective of the present study was to evaluate the effects of silicic acid on the development, productivity and level of infestation by beetles and aphids following foliar application to potato plants cultivated in the presence of organic compost or chemical fertiliser. Four experimental groups were studied, namely, plants cultivated in soil supplied with organic compost (30 t/ha and either treated or non-treated with 0.5% silicic acid, and plants cultivated in soil supplied with NPK fertiliser (4:14:8; 4 t/ha and either treated or non-treated with 0.5% silicic acid. The number of aphids and beetles detected on the leaves and the number of lesions caused by the beetles were evaluated. The height and the stem diameter of the plants were determined 60 days after the emergence and the productivity was determined 95 days after the planting of the seed potatoes. The results demonstrated that there were no interactions between silicic acid treatment and way of cultivation. Moreover, the incidence of beetles and aphids was not influenced by weekly application of silicon, and neither were the development and the productivity of plants. Although the development and productivity of organically cultivated plants were inferior to those grown in the presence of chemical fertiliser, plants cultivated on organic compost were less susceptible to attack by beetles.A cultura da batata é suscetível a diversos insetos-praga, incluindo os pulgões (Hemiptera: Aphididae e a vaquinha Diabrotica speciosa (Coleoptera: Chrysomelidae. A indução de resistência, por meio do tratamento com silício, é uma das táticas usadas no manejo integrado de pragas. Objetivou-se, no presente trabalho

  14. Fine mapping of the NRG1 Hirschsprung's disease locus.

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    Clara Sze-Man Tang

    Full Text Available The primary pathology of Hirschsprung's disease (HSCR, colon aganglionosis is the absence of ganglia in variable lengths of the hindgut, resulting in functional obstruction. HSCR is attributed to a failure of migration of the enteric ganglion precursors along the developing gut. RET is a key regulator of the development of the enteric nervous system (ENS and the major HSCR-causing gene. Yet the reduced penetrance of RET DNA HSCR-associated variants together with the phenotypic variability suggest the involvement of additional genes in the disease. Through a genome-wide association study, we uncovered a ∼350 kb HSCR-associated region encompassing part of the neuregulin-1 gene (NRG1. To identify the causal NRG1 variants contributing to HSCR, we genotyped 243 SNPs variants on 343 ethnic Chinese HSCR patients and 359 controls. Genotype analysis coupled with imputation narrowed down the HSCR-associated region to 21 kb, with four of the most associated SNPs (rs10088313, rs10094655, rs4624987, and rs3884552 mapping to the NRG1 promoter. We investigated whether there was correlation between the genotype at the rs10088313 locus and the amount of NRG1 expressed in human gut tissues (40 patients and 21 controls and found differences in expression as a function of genotype. We also found significant differences in NRG1 expression levels between diseased and control individuals bearing the same rs10088313 risk genotype. This indicates that the effects of NRG1 common variants are likely to depend on other alleles or epigenetic factors present in the patients and would account for the variability in the genetic predisposition to HSCR.

  15. HLA Class II Locus and Susceptibility to Podoconiosis

    Science.gov (United States)

    Ayele, Fasil Tekola; Adeyemo, Adebowale; Finan, Chris; Hailu, Elena; Sinnott, Paul; Burlinson, Natalia Diaz; Aseffa, Abraham; Rotimi, Charles N.; Newport, Melanie J.; Davey, Gail

    2012-01-01

    BACKGROUND Podoconiosis is a tropical lymphedema resulting from long-term barefoot exposure to red-clay soil derived from volcanic rock. The World Health Organization recently designated it as a neglected tropical disease. Podoconiosis develops in only a subgroup of exposed people, and studies have shown familial clustering with high heritability (63%). METHODS We conducted a genomewide association study of 194 case patients and 203 controls from southern Ethiopia. Findings were validated by means of family-based association testing in 202 family trios and HLA typing in 94 case patients and 94 controls. RESULTS We found a genomewide significant association of podoconiosis with the single-nucleotide polymorphism (SNP) rs17612858, located 5.8 kb from the HLA-DQA1 locus (in the allelic model: odds ratio, 2.44; 95% confidence interval [CI], 1.82 to 3.26; P = 1.42×10−9; and in the additive model: odds ratio, 2.19; 95% CI, 1.66 to 2.90; P = 3.44×10−8), and suggestive associations (PHLA-DQA1, and HLA-DRB1. We confirmed these associations using family-based association testing. HLA typing showed the alleles HLA-DRB1*0701 (odds ratio, 2.00), DQA1*0201 (odds ratio, 1.91), and DQB1*0202 (odds ratio, 1.79) and the HLA-DRB1*0701–DQB1*0202 haplotype (odds ratio, 1.92) were risk variants for podoconiosis. CONCLUSIONS Association between variants in HLA class II loci with podoconiosis (a noncommuni-cable disease) suggests that the condition may be a T-cell–mediated inflammatory disease and is a model for gene–environment interactions that may be relevant to other complex genetic disorders. (Funded by the Wellcome Trust and others.) PMID:22455414

  16. Locus-specific ribosomal RNA gene silencing in nucleolar dominance.

    Directory of Open Access Journals (Sweden)

    Michelle S Lewis

    2007-08-01

    Full Text Available The silencing of one parental set of rRNA genes in a genetic hybrid is an epigenetic phenomenon known as nucleolar dominance. We showed previously that silencing is restricted to the nucleolus organizer regions (NORs, the loci where rRNA genes are tandemly arrayed, and does not spread to or from neighboring protein-coding genes. One hypothesis is that nucleolar dominance is the net result of hundreds of silencing events acting one rRNA gene at a time. A prediction of this hypothesis is that rRNA gene silencing should occur independent of chromosomal location. An alternative hypothesis is that the regulatory unit in nucleolar dominance is the NOR, rather than each individual rRNA gene, in which case NOR localization may be essential for rRNA gene silencing. To test these alternative hypotheses, we examined the fates of rRNA transgenes integrated at ectopic locations. The transgenes were accurately transcribed in all independent transgenic Arabidopsis thaliana lines tested, indicating that NOR localization is not required for rRNA gene expression. Upon crossing the transgenic A. thaliana lines as ovule parents with A. lyrata to form F1 hybrids, a new system for the study of nucleolar dominance, the endogenous rRNA genes located within the A. thaliana NORs are silenced. However, rRNA transgenes escaped silencing in multiple independent hybrids. Collectively, our data suggest that rRNA gene activation can occur in a gene-autonomous fashion, independent of chromosomal location, whereas rRNA gene silencing in nucleolar dominance is locus-dependent.

  17. The 4q27 locus and prostate cancer risk

    International Nuclear Information System (INIS)

    Tindall, Elizabeth A; Hoang, Hoa N; Southey, Melissa C; English, Dallas R; Hopper, John L; Giles, Graham G; Severi, Gianluca; Hayes, Vanessa M

    2010-01-01

    Chronic inflammation is considered to be implicated in the development of prostate cancer. In this study we are the first to investigate a potential association between variants in an autoimmune related region on chromosome 4q27 and prostate cancer risk. This region harbors two cytokine genes IL-2 and the recently described IL-21. We genotyped six variants previously associated with autoimmune disease (namely rs13151961, rs13119723, rs17388568, rs3136534, rs6822844 and rs6840978) and one functional IL-2 promoter variant (rs2069762) for possible association with prostate cancer risk using the Australian Risk Factors for Prostate Cancer case-control Study. Overall, our results do not support an association between the seven variants at position 4q27 and prostate cancer risk. Per allele odds ratios (ORs) were not significantly different from 1 (all P-values = 0.06). However, we found suggestive evidence for a significant association between the presence of the rs13119723 variant (located in a protein of unknown function) and men with a family history of prostate cancer in first-degree relatives (P-value for interaction 0.02). The per allele OR associated with this variant was significantly higher than 1 (2.37; 95% C.I. = 1.01-5.57). We suggest that genetic variation within the chromosome 4q27 locus might be associated with prostate cancer susceptibility in men with a family history of the disease. Furthermore, our study alludes to a potential role of unknown protein KIAA1109 in conferring this risk

  18. Extratores de silício disponível em escórias e fertilizantes Extractors of available silicon in slags and fertilizers

    Directory of Open Access Journals (Sweden)

    H. S. Pereira

    2003-04-01

    Full Text Available Os métodos para quantificar o silício (Si disponível em fertilizantes e escórias não têm sido confiáveis até o momento. Neste estudo, determinou-se o Si extraído de diversas fontes, utilizando como extratores: Na2CO3 + NH4NO3, variando concentração, tempo de agitação e de reação; água; HCl 0,5 mol dm-3; Na2CO3 a 50 g dm-3; ácido cítrico a 50 g dm-3; ácido acético 0,5 mol dm-3; resina trocadora de cátions (Amberlite IRC-50, pK 6,1, além do método da coluna de lixiviação. Paralelamente, desenvolveu-se um experimento em casa de vegetação, com arroz irrigado, com aplicação de 125 kg ha-1 de Si total, proveniente de 12 fontes. O tempo de agitação mostrou não ser fundamental na determinação do Si, embora o resultado de três horas tenha sido superior estatisticamente aos demais. As concentrações de 10 + 16 g dm-3 e 30 + 48 g dm-3 de Na2CO3 + NH4NO3 mostraram-se as mais promissoras na extração de Si; por isso a menor concentração (10 + 16 g dm-3 foi escolhida para avaliar as fontes quanto ao tempo de repouso. Durante o período de repouso, verificou-se que todas as fontes apresentaram aumento na liberação de Si ao longo do tempo, tendo o período de 5 a 9 dias apresentado melhor correlação entre o Si extraído pelo arroz e o Si recuperado na análise das várias fontes. A extração com Na2CO3 + NH4NO3 dos fertilizantes com Si pode representar, com um bom grau de confiabilidade, o potencial de liberação deste elemento no solo e aproveitamento pelas plantas. As fontes mais eficientes na liberação de Si para o arroz foram a Rhodia, seguida da Wollastonita, enquanto as fontes MB-4 e escórias de alto-forno foram as que menos liberaram Si. Os extratores ácidos demonstraram ser mais eficientes na extração de Si das escórias de alto-forno e pouco eficientes com a Wollastonita. A água foi o extrator com a menor taxa de recuperação de Si das fontes testadas. Os extratores que apresentaram melhores correla

  19. Genetic structure and invasion history of the house mouse (Mus musculus domesticus) in Senegal, West Africa: a legacy of colonial and contemporary times.

    Science.gov (United States)

    Lippens, C; Estoup, A; Hima, M K; Loiseau, A; Tatard, C; Dalecky, A; Bâ, K; Kane, M; Diallo, M; Sow, A; Niang, Y; Piry, S; Berthier, K; Leblois, R; Duplantier, J-M; Brouat, C

    2017-08-01

    Knowledge of the genetic make-up and demographic history of invasive populations is critical to understand invasion mechanisms. Commensal rodents are ideal models to study whether complex invasion histories are typical of introductions involving human activities. The house mouse Mus musculus domesticus is a major invasive synanthropic rodent originating from South-West Asia. It has been largely studied in Europe and on several remote islands, but the genetic structure and invasion history of this taxon have been little investigated in several continental areas, including West Africa. In this study, we focussed on invasive populations of M. m. domesticus in Senegal. In this focal area for European settlers, the distribution area and invasion spread of the house mouse is documented by decades of data on commensal rodent communities. Genetic variation at one mitochondrial locus and 16 nuclear microsatellite markers was analysed from individuals sampled in 36 sites distributed across the country. A combination of phylogeographic and population genetics methods showed that there was a single introduction event on the northern coast of Senegal, from an exogenous (probably West European) source, followed by a secondary introduction from northern Senegal into a coastal site further south. The geographic locations of these introduction sites were consistent with the colonial history of Senegal. Overall, the marked microsatellite genetic structure observed in Senegal, even between sites located close together, revealed a complex interplay of different demographic processes occurring during house mouse spatial expansion, including sequential founder effects and stratified dispersal due to human transport along major roads.

  20. Invasive plant species in hardwood tree plantations

    Science.gov (United States)

    Rochelle R. Beasley; Paula M. Pijut

    2010-01-01

    Invasive plants are species that can grow and spread aggressively, mature quickly, and invade an ecosystem causing economic and environmental damage. Invasive plants usually invade disturbed areas, but can also colonize small areas quickly, and may spread and dominate large areas in a few short years. Invasive plant species displace native or desirable forest...

  1. Invasive plants in 21st Century landscapes.

    Science.gov (United States)

    Valerie. Rapp

    2005-01-01

    A plant species is defined as invasive if it is nonnative to the ecosystem under consideration, and if it causes or is likely to cause economic or environmental harm or harm to human health. Nonnative plant invasions are generally considered to have reached the Pacific Northwest in the mid-1800s with the arrival of European-American settlers. Invasive species such as...

  2. Invasive Species Science Update (No. 9)

    Science.gov (United States)

    Justin Runyon

    2017-01-01

    This newsletter is designed to keep managers and other users up-to-date with recently completed and ongoing research by RMRS scientists, as well as to highlight breaking news related to invasive species issues. The newsletter is produced by the RMRS Invasive Species Working Group (ISWG), a core group of scientists who volunteer to disseminate RMRS invasive species...

  3. Do invasive plant species alter soil health?

    Science.gov (United States)

    Invasive species may alter soil characteristics or interact with the soil microbial community to yield a competitive advantage. Our objectives were to determine: if invasive plant species alter soil properties important to soil health; and the long-term effects of invasive plant species on soil pro...

  4. 78 FR 70317 - Invasive Species Advisory Committee

    Science.gov (United States)

    2013-11-25

    ... DEPARTMENT OF THE INTERIOR Office of the Secretary Invasive Species Advisory Committee AGENCY..., notice is hereby given of meetings of the Invasive Species Advisory Committee. The purpose of the Advisory Committee is to provide advice to the National Invasive Species Council, as authorized by...

  5. Invasive species and climate change (Chapter 7)

    Science.gov (United States)

    Justin B. Runyon; Jack L. Butler; Megan M. Friggens; Susan E. Meyer; Sharlene E. Sing

    2012-01-01

    Invasive species present one of the greatest threats to the health and sustainability of ecosystems worldwide. Invasive plants, animals, and diseases are known to have significant negative effects on biological diversity and the ecological structure and functions of native ecosystems. Moreover, the economic cost imposed by invasive species is enormous—the damage...

  6. Invasive Species Science Update (No. 4)

    Science.gov (United States)

    Ned B. Klopfenstein; Brian W. Geils

    2010-01-01

    The fourth issue of Invasive Species Science Update has finally arrived. This newsletter has no set publication schedule, but our intent is to deliver invasive species information on a timely basis. The RMRS Invasive Species Working Group (ISWG) has been reorganized and recharged. General information on the ISWG is presented in a publication by Butler and others (2009...

  7. Invasive Species Science Update (No. 7)

    Science.gov (United States)

    Dean Pearson; Yvette Ortega; Jack Butler

    2014-01-01

    Invasive Species Science Updates are designed to keep managers and other users up-to-date with recently completed and ongoing research by RMRS scientists, as well as highlight breaking news related to invasive species issues. The newsletter is produced by the RMRS Invasive Species Working Group (ISWG), which is a core group of scientists who volunteer to coordinate...

  8. Invasive Species Science Update (No. 5)

    Science.gov (United States)

    Dean Pearson; Yvette Ortega

    2011-01-01

    Welcome to the fifth issue of the Rocky Mountain Research Station's (RMRS) Invasive Species Science Update. The newsletter is produced by the RMRS Invasive Species Working Group (ISWG), which is a core group of scientists who volunteer to coordinate outreach of RMRS invasive species science to managers and the public. After publishing the past four newsletters, we...

  9. 78 FR 11899 - Invasive Species Advisory Committee

    Science.gov (United States)

    2013-02-20

    ... DEPARTMENT OF THE INTERIOR Office of the Secretary Invasive Species Advisory Committee AGENCY... notice of public meetings of the Invasive Species Advisory Committee. The document contained incorrect..., March 6, 2013; 9 a.m. to 1:45 p.m. Meeting of the Invasive Species Advisory Committee (OPEN): Thursday...

  10. Invasive Species Science Update (No. 8)

    Science.gov (United States)

    Dean Pearson; Yvette Ortega; Jack Butler

    2015-01-01

    Invasive Species Science Updates are designed to keep managers and other users up-to-date with recently completed and ongoing research by RMRS scientists, as well as highlight breaking news related to invasive species issues. The newsletter is produced by the RMRS Invasive Species Working Group (ISWG), which is a core group of scientists who volunteer to coordinate...

  11. Terrestrial animals as invasive species and as species at risk from invasions

    Science.gov (United States)

    Deborah M. Finch; Dean Pearson; Joseph Wunderle; Wayne Arendt

    2010-01-01

    Including terrestrial animal species in the invasive species strategy plan is an important step in invasive species management. Invasions by nonindigenous species threaten nearly 50 percent of imperiled native species in the United States and are the Nation's second leading cause of species endangerment. Invasion and conversion of native habitats by exotic species...

  12. Effectiveness of teaching cognitive-behavioral techniques on locus of control in hemodialysis patients.

    Science.gov (United States)

    Mehrtak, Mohammad; Habibzadeh, Shahram; Farzaneh, Esmaeil; Rjaei-Khiavi, Abdollah

    2017-10-01

    Many of the cognitive behavioral models and therapeutic protocols developed so far for psychological disorders and chronic diseases have proved effective through clinical research. This study aimed to determine the effectiveness of teaching cognitive-behavioral techniques on locus of control in hemodialysis patients. This controlled clinical trial study was conducted in 2015 with 76 patients selected by census and treated with a hemodialysis machine in the dialysis department of Vali-Asr Hospital in the city of Meshkinshahr. A total of four patients were excluded because of their critical conditions while the rest, who were recruited, were randomly divided into two equal groups of 36 patients as the intervention and control groups. First, the locus of control was measured in both groups through a pretest, and cognitive-behavioral techniques were then taught to the intervention group during eight 45 to 90-minute sessions. The locus of control in patients of both groups was finally re-measured through a posttest. Data were collected using Rotter's Locus of Control Inventory. The Wilcoxon test and Mann-Whitney U test were respectively used in SPSS18 for data analysis. In the pretest and posttest stages respectively, 4.8% and 14.3% of samples in the control group as well as 14.3% and 33.3% of samples in the intervention group enjoyed internal locus of control. The difference between the pretest and posttest scores of internal locus of control in the intervention group was significant (p=0.004), which indicates the positive effect of cognitive-behavioral psychotherapeutic intervention on internalization of locus of control in this group. Given the external locus of control in most of the study patients and also the positive significant effect of cognitive-behavioral psychotherapy on internalization of locus of control in this group of patients, it appears necessary to have a psychology resident present in the hemodialysis department to teach the necessary cognitive

  13. The risk of establishment of aquatic invasive species: joining invasibility and propagule pressure.

    Science.gov (United States)

    Leung, Brian; Mandrak, Nicholas E

    2007-10-22

    Invasive species are increasingly becoming a policy priority. This has spurred researchers and managers to try to estimate the risk of invasion. Conceptually, invasions are dependent both on the receiving environment (invasibility) and on the ability to reach these new areas (propagule pressure). However, analyses of risk typically examine only one or the other. Here, we develop and apply a joint model of invasion risk that simultaneously incorporates invasibility and propagule pressure. We present arguments that the behaviour of these two elements of risk differs substantially--propagule pressure is a function of time, whereas invasibility is not--and therefore have different management implications. Further, we use the well-studied zebra mussel (Dreissena polymorpha) to contrast predictions made using the joint model to those made by separate invasibility and propagule pressure models. We show that predictions of invasion progress as well as of the long-term invasion pattern are strongly affected by using a joint model.

  14. Invasive procedures with questionable indications

    Directory of Open Access Journals (Sweden)

    Sergei V. Jargin

    2014-12-01

    Full Text Available Insufficient coordination of medical research and partial isolation from the international scientific community can result in application of invasive methods without sufficient indications. Here is presented an overview of renal and pancreatic biopsy studies performed in the course of the operations of pancreatic blood shunting into the systemic blood flow in type 1 diabetic patients. Furthermore a surgical procedure of lung denervation as a treatment method of asthma as well as the use of bronchoscopy for research in asthmatics are discussed here. Today, the upturn in Russian economy enables acquisition of modern equipment; and medical research is on the increase. Under these circumstances, the purpose of this letter was to remind that, performing surgical or other invasive procedures, the risk-to-benefit ratio should be kept as low as possible.

  15. Radiologic aspects in invasive aspergillosis

    International Nuclear Information System (INIS)

    Feger, C.; Kerviler, E. de; Zagdanski, A.M.; Attal, P.; Cyna-Gorse, F.; Frija, J.; Laval-Jeantet, M.

    1994-01-01

    Invasive aspergillosis is a life-threatening illness, whose diagnosis is difficult: clinical signs are indeed not specific, and biological and mycological exams are not always conclusive. Radiological exams are essential for the diagnosis of this disease allowing to start an early intensive appropriate therapy. According to the literature and to their own experience the authors report the main radiological patterns with emphasis on the pulmonary and cerebral affections. (authors). 26 refs., 5 figs

  16. Non-invasive extending prosthesis

    OpenAIRE

    Meswania, Jayantilal Mohanlal

    2006-01-01

    Most sarcomas of the bone occur in patients of a relatively young age including skeletally immature patients. Approximately 50 child sarcomas are treated with limb salvage surgery per year in the United Kingdom. These children need an extendible implant that can be lengthened periodically to keep pace with the growth in the opposite limb. Surgically, invasive devices have been used for the past thirty years with intrinsic problems of infection and long-term recurrent trauma to the patient. To...

  17. Agriculture familiale et politiques publiques de développement territorial : le cas du Brésil de Lula

    Directory of Open Access Journals (Sweden)

    Eric Sabourin

    2009-03-01

    Full Text Available Le gouvernement de Lula a considérablement amplifié et diversifié le Programme d'Appui à l'Agriculture Familiale (PRONAF, créé par le gouvernement Fernando Henrique Cardoso en 1995. Ce choix affirmé sur la longue durée pour l'agriculture familiale, peut surprendre dans un Brésil qui a toujours, tout au long de son histoire, privilégié l’agriculture « d'entreprise » : latifundia et entreprises agricoles. L'article analyse les mécanismes qui ont conduit à ces choix sociétaux, en examinant en particulier le rôle des organisations syndicales et paysannes dans la « construction » du Programme d'Appui à l'Agriculture Familiale (PRONAF et du Programme de Développement Durable des Territoires Ruraux (PDSTR. La permanence de l'agriculture familiale dans l'histoire brésilienne est expliquée par sa capacité d'adaptation et de résistance, même face à des projets de modernisation irréalistes qui ne prenaient pas en compte les avantages comparatifs de l'agriculture familiale. Cette capacité d'adaptation naît d'une expérimentation au quotidien, dans des histoires de « développement local ». Des groupes d'agriculteurs testent techniques, pratiques ou organisations. Le dynamisme de ces mouvements en a fait des partenaires naturels de l'Etat dans l'élaboration et la mise en œuvre du PRONAF.Au-delà des difficultés et du manque de moyens, au quotidien, dans les relations entre acteurs, une pratique de mise en œuvre du PRONAF a été inventée. Une nouvelle gouvernance s'est instituée entre mouvement social et gouvernement. . Pour le MDA, et plus particulièrement, pour le Secrétariat du Développement Territorial (SDT, le territoire est le lieu privilégié de cette nouvelle gouvernance. Le PRONAF et le PDSTR sont représentatifs de ce que tendent à devenir les politiques publiques pour répondre aux défis d'un futur, toujours plus incertain. Ils sont l’exemple de programme co-définis dans la continuit

  18. Biological invasions, ecological resilience and adaptive governance

    Science.gov (United States)

    Chaffin, Brian C.; Garmestani, Ahjond S.; Angeler, David G.; Herrmann, Dustin L.; Stow, Craig A.; Nystrom, Magnus; Sendzimir, Jan; Hopton, Matthew E.; Kolasa, Jurek; Allen, Craig R.

    2016-01-01

    In a world of increasing interconnections in global trade as well as rapid change in climate and land cover, the accelerating introduction and spread of invasive species is a critical concern due to associated negative social and ecological impacts, both real and perceived. Much of the societal response to invasive species to date has been associated with negative economic consequences of invasions. This response has shaped a war-like approach to addressing invasions, one with an agenda of eradications and intense ecological restoration efforts towards prior or more desirable ecological regimes. This trajectory often ignores the concept of ecological resilience and associated approaches of resilience-based governance. We argue that the relationship between ecological resilience and invasive species has been understudied to the detriment of attempts to govern invasions, and that most management actions fail, primarily because they do not incorporate adaptive, learning-based approaches. Invasive species can decrease resilience by reducing the biodiversity that underpins ecological functions and processes, making ecosystems more prone to regime shifts. However, invasions do not always result in a shift to an alternative regime; invasions can also increase resilience by introducing novelty, replacing lost ecological functions or adding redundancy that strengthens already existing structures and processes in an ecosystem. This paper examines the potential impacts of species invasions on the resilience of ecosystems and suggests that resilience-based approaches can inform policy by linking the governance of biological invasions to the negotiation of tradeoffs between ecosystem services.

  19. Participation of locus coeruleus in breathing control in female rats.

    Science.gov (United States)

    de Carvalho, Débora; Patrone, Luis Gustavo A; Marques, Danuzia A; Vicente, Mariane C; Szawka, Raphael E; Anselmo-Franci, Janete A; Bícego, Kênia C; Gargaglioni, Luciane H

    2017-11-01

    Several evidences indicate that the locus coeruleus (LC) is involved in central chemoreception responding to CO 2 /pH and displaying a high percentage of chemosensitive neurons (>80%). However, there are no studies about the LC-mediated hypercapnic ventilation performed in females. Therefore, we assessed the role of noradrenergic LC neurons in non-ovariectomized (NOVX), ovariectomized (OVX) and estradiol (E2)-treated ovariectomized (OVX+E2) rats in respiratory response to hypercapnia, using a 6-hydroxydopamine (6-OHDA) - lesion model. A reduction in the number of tyrosine hydroxylase (TH) immunoreactive neurons (51-90% in 3 animals of NOVX group, 20-42% of lesion in 5 animals of NOVX females, 61.3% for OVX and 62.6% for OVX+E2 group) was observed seven days after microinjection of 6-OHDA in the LC. The chemical lesion of the LC resulted in decreased respiratory frequency under normocapnic conditions in OVX and OVX+E2 group. Hypercapnia increased ventilation in all groups as consequence of increases in respiratory frequency (fR) and tidal volume (V T ). Nevertheless, the hypercapnic ventilatory response was significantly decreased in 6-OHDA-NOVX>50% rats compared with SHAM-NOVX group and with females that had 20-42% of LC lesion. In OVX and OVX+E2 lesioned groups, no difference in CO 2 ventilatory response was observed when compared to SHAM-OVX and SHAM-OVX+E2 groups, respectively. Neither basal body temperature (Tb) nor Tb reduction in response to hypercapnia were affected by E2 treatment, ovariectomy or LC lesion. Thus, our data show that LC noradrenergic neurons seem to exert an excitatory role on the hypercapnic ventilatory response in female rats, as evidenced by the results in NOVX animals with LC lesioned more than 50%; however, this modulation is not observed in OVX and OVX+E2 rats. In addition, LC noradrenergic neurons of OVX females seem to provide a tonic excitatory drive to maintain breathing frequency in normocapnia, and this response may not to be

  20. Maxwell Strata and Cut Locus in the Sub-Riemannian Problem on the Engel Group

    Science.gov (United States)

    Ardentov, Andrei A.; Sachkov, Yuri L.

    2017-12-01

    We consider the nilpotent left-invariant sub-Riemannian structure on the Engel group. This structure gives a fundamental local approximation of a generic rank 2 sub-Riemannian structure on a 4-manifold near a generic point (in particular, of the kinematic models of a car with a trailer). On the other hand, this is the simplest sub-Riemannian structure of step three. We describe the global structure of the cut locus (the set of points where geodesics lose their global optimality), the Maxwell set (the set of points that admit more than one minimizer), and the intersection of the cut locus with the caustic (the set of conjugate points along all geodesics). The group of symmetries of the cut locus is described: it is generated by a one-parameter group of dilations R+ and a discrete group of reflections Z2 × Z2 × Z2. The cut locus admits a stratification with 6 three-dimensional strata, 12 two-dimensional strata, and 2 one-dimensional strata. Three-dimensional strata of the cut locus are Maxwell strata of multiplicity 2 (for each point there are 2 minimizers). Two-dimensional strata of the cut locus consist of conjugate points. Finally, one-dimensional strata are Maxwell strata of infinite multiplicity, they consist of conjugate points as well. Projections of sub-Riemannian geodesics to the 2-dimensional plane of the distribution are Euler elasticae. For each point of the cut locus, we describe the Euler elasticae corresponding to minimizers coming to this point. Finally, we describe the structure of the optimal synthesis, i. e., the set of minimizers for each terminal point in the Engel group.

  1. Detailed mapping of a resistance locus against Fusarium wilt in cultivated eggplant (Solanum melongena).

    Science.gov (United States)

    Miyatake, Koji; Saito, Takeo; Negoro, Satomi; Yamaguchi, Hirotaka; Nunome, Tsukasa; Ohyama, Akio; Fukuoka, Hiroyuki

    2016-02-01

    This is the first report on genetic mapping of a resistance locus against Fusarium wilt caused by the plant pathogen Fusarium oxysporum f. sp. melongenae in cultivated eggplant. Fusarium wilt, caused by the plant pathogen Fusarium oxysporum f. sp. melongenae, is a major soil-borne disease threatening stable production in eggplant (Solanum melongena). Although three eggplant germplasms, LS1934, LS174, and LS2436, are known to be highly resistant to the pathogen, their resistance loci have not been mapped. In this study, we performed quantitative trait locus analyses in F2:3 populations and detected a resistance locus, FM1, at the end of chromosome 2, with two alleles, Fm1(L) and Fm1(E), in the F2 populations LWF2 [LS1934 × WCGR112-8 (susceptible)] and EWF2 [EPL-1 (derived from LS174) × WCGR112-8], respectively. The percentage of phenotypic variance explained by Fm1(L) derived from LS1934 was 75.0% [Logarithm of the odds (LOD) = 29.3], and that explained by Fm1(E) derived from EPL-1 was 92.2% (LOD = 65.8). Using backcrossed inbred lines, we mapped FM1 between two simple sequence repeat markers located ~4.881 cM apart from each other. Comparing the location of the above locus to those of previously reported ones, the resistance locus Rfo-sa1 from an eggplant ally (Solanum aethiopicum gr. Gilo) was mapped very close to FM1, whereas another resistance locus, from LS2436, was mapped to the middle of chromosome 4. This is the first report of mapping of a Fusarium resistance locus in cultivated eggplant. The availability of resistance-linked markers will enable the application of marker-assisted selection to overcome problems posed by self-incompatibility and introduction of negative traits because of linkage drag, and will lead to clear understanding of genetic mechanism of Fusarium resistance.

  2. Invasive predators and global biodiversity loss.

    Science.gov (United States)

    Doherty, Tim S; Glen, Alistair S; Nimmo, Dale G; Ritchie, Euan G; Dickman, Chris R

    2016-10-04

    Invasive species threaten biodiversity globally, and invasive mammalian predators are particularly damaging, having contributed to considerable species decline and extinction. We provide a global metaanalysis of these impacts and reveal their full extent. Invasive predators are implicated in 87 bird, 45 mammal, and 10 reptile species extinctions-58% of these groups' contemporary extinctions worldwide. These figures are likely underestimated because 23 critically endangered species that we assessed are classed as "possibly extinct." Invasive mammalian predators endanger a further 596 species at risk of extinction, with cats, rodents, dogs, and pigs threatening the most species overall. Species most at risk from predators have high evolutionary distinctiveness and inhabit insular environments. Invasive mammalian predators are therefore important drivers of irreversible loss of phylogenetic diversity worldwide. That most impacted species are insular indicates that management of invasive predators on islands should be a global conservation priority. Understanding and mitigating the impact of invasive mammalian predators is essential for reducing the rate of global biodiversity loss.

  3. Will climate change promote future invasions?

    Science.gov (United States)

    Bellard, Celine; Thuiller, Wilfried; Leroy, Boris; Genovesi, Piero; Bakkenes, Michel; Courchamp, Franck

    2013-12-01

    Biological invasion is increasingly recognized as one of the greatest threats to biodiversity. Using ensemble forecasts from species distribution models to project future suitable areas of the 100 of the world's worst invasive species defined by the International Union for the Conservation of Nature, we show that both climate and land use changes will likely cause drastic species range shifts. Looking at potential spatial aggregation of invasive species, we identify three future hotspots of invasion in Europe, northeastern North America, and Oceania. We also emphasize that some regions could lose a significant number of invasive alien species, creating opportunities for ecosystem restoration. From the list of 100, scenarios of potential range distributions show a consistent shrinking for invasive amphibians and birds, while for aquatic and terrestrial invertebrates distributions are projected to substantially increase in most cases. Given the harmful impacts these invasive species currently have on ecosystems, these species will likely dramatically influence the future of biodiversity. © 2013 John Wiley & Sons Ltd.

  4. 3D-CRT, Proton, or Brachytherapy APBI in Treating Patients With Invasive and Non-invasive Breast Cancer

    Science.gov (United States)

    2017-12-29

    Ductal Breast Carcinoma In Situ; Estrogen Receptor Positive; Grade 1 Invasive Breast Carcinoma; Grade 2 Invasive Breast Carcinoma; Grade 3 Invasive Breast Carcinoma; Invasive Ductal and Lobular Carcinoma In Situ; Mucinous Breast Carcinoma; Tubular Breast Carcinoma

  5. Laboratory characterization of invasive Haemophilus influenzae isolates from Nunavut, Canada, 2000-2012.

    Science.gov (United States)

    Tsang, Raymond S W; Li, Y Anita; Mullen, Angie; Baikie, Maureen; Whyte, Kathleen; Shuel, Michelle; Tyrrell, Gregory; Rotondo, Jenny A L; Desai, Shalini; Spika, John

    2016-01-01

    With invasive Haemophilus influenzae serotype b (Hib) disease controlled by vaccination with conjugate Hib vaccines, there is concern that invasive disease due to non-serotype b strains may emerge. This study characterized invasive H. influenzae (Hi) isolates from Nunavut, Canada, in the post-Hib vaccine era. Invasive H. influenzae isolates were identified by conventional methods at local hospitals; and further characterized at the provincial and federal public health laboratories, including detection of serotype antigens and genes, multi-locus sequence typing and antibiotic susceptibility. Of the 89 invasive H. influenzae cases identified from 2000 to 2012, 71 case isolates were available for study. There were 43 serotype a (Hia), 12 Hib, 2 Hic, 1 Hid, 1 Hie, 2 Hif and 10 were non-typeable (NT). All 43 Hia were biotype II, sequence type (ST)-23. Three related STs were found among the Hib isolates: ST-95 (n=9), ST-635 (n=2) and ST-44 (n=1). Both Hif belonged to ST-124 and the 2 Hic were typed as ST-9. The remaining Hid (ST-1288) and Hie (ST-18) belonged to 2 separate clones. Of the 10 NT strains, 3 were typed as ST-23 and the remaining 7 isolates each belonged to a unique ST. Eight Hib and 1 NT-Hi were found to be resistant to ampicillin due to β-lactamase production. No resistance to other antibiotics was detected. During the period of 2000-2012, Hia was the predominant serotype causing invasive disease in Nunavut. This presents a public health concern due to an emerging clone of Hia as a cause of invasive H. influenzae disease and the lack of published guidelines for the prophylaxis of contacts. The clonal nature of Hia could be the result of spread within an isolated population, and/or unique characteristics of this strain to cause invasive disease. Further study of Hia in other populations may provide important information on this emerging pathogen. No antibiotic resistance was detected among Hia isolates; a small proportion of Hib and NT-Hi isolates

  6. Confirmatory factor analysis and invariance testing between Blacks and Whites of the Multidimensional Health Locus of Control scale.

    Science.gov (United States)

    LaNoue, Marianna; Harvey, Abby; Mautner, Dawn; Ku, Bon; Scott, Kevin

    2015-07-01

    The factor structure of the Multidimensional Health Locus of Control scale remains in question. Additionally, research on health belief differences between Black and White respondents suggests that the Multidimensional Health Locus of Control scale may not be invariant. We reviewed the literature regarding the latent variable structure of the Multidimensional Health Locus of Control scale, used confirmatory factor analysis to confirm the three-factor structure of the Multidimensional Health Locus of Control, and analyzed between-group differences in the Multidimensional Health Locus of Control structure and means across Black and White respondents. Our results indicate differences in means and structure, indicating more research is needed to inform decisions regarding whether and how to deploy the Multidimensional Health Locus of Control appropriately.

  7. Performance of serum biomarkers for the early detection of invasive aspergillosis in febrile, neutropenic patients: a multi-state model.

    Directory of Open Access Journals (Sweden)

    Michaël Schwarzinger

    Full Text Available The performance of serum biomarkers for the early detection of invasive aspergillosis expectedly depends on the timing of test results relative to the empirical administration of antifungal therapy during neutropenia, although a dynamic evaluation framework is lacking.We developed a multi-state model describing simultaneously the likelihood of empirical antifungal therapy and the risk of invasive aspergillosis during neutropenia. We evaluated whether the first positive test result with a biomarker is an independent predictor of invasive aspergillosis when both diagnostic information used to treat and risk factors of developing invasive aspergillosis are taken into account over time. We applied the multi-state model to a homogeneous cohort of 185 high-risk patients with acute myeloid leukemia. Patients were prospectively screened for galactomannan antigenemia twice a week for immediate treatment decision; 2,214 serum samples were collected on the same days and blindly assessed for (1->3- β-D-glucan antigenemia and a quantitative PCR assay targeting a mitochondrial locus.The usual evaluation framework of biomarker performance was unable to distinguish clinical benefits of β-glucan or PCR assays. The multi-state model evidenced that the risk of invasive aspergillosis is a complex time function of neutropenia duration and risk management. The quantitative PCR assay accelerated the early detection of invasive aspergillosis (P = .010, independently of other diagnostic information used to treat, while β-glucan assay did not (P = .53.The performance of serum biomarkers for the early detection of invasive aspergillosis is better apprehended by the evaluation of time-varying predictors in a multi-state model. Our results provide strong rationale for prospective studies testing a preemptive antifungal therapy, guided by clinical, radiological, and bi-weekly blood screening with galactomannan antigenemia and a standardized quantitative PCR assay.

  8. Desempenho em consciência silábica e fonêmica em crianças com desenvolvimento de fala normal e desviante Performance in syllabic and phonemic awareness in children with normal and disordered speech development

    Directory of Open Access Journals (Sweden)

    Paula Tavares Marchetti

    2010-02-01

    Full Text Available OBJETIVO: comparar o desempenho nas habilidades metafonológicas, no nível silábico e fonêmico, por meio do Protocolo de Tarefas de Consciência Fonológica (Cielo, 2001 entre crianças com desenvolvimento de fala normal e desviante (DFE, com idades entre 4 e 8 anos. MÉTODOS: participaram da pesquisa 49 sujeitos, 26 do GR (grupo de referência sem DFE, os quais fizeram parte da pesquisa de Cielo (2001 e 23 do GE (grupo de estudo com DFE. Todos os sujeitos foram submetidos à avaliação fonoaudiológica e da consciência fonológica (CF. RESULTADOS: dos 12 subtestes, envolvendo consciência silábica, em seis (50% houve diferença estatisticamente significante entre o GE e o GR, confirmando o pior desempenho do GE. Nos 10 subtestes envolvendo as tarefas de consciência fonêmica, em seis (60% apresentaram diferenças estatisticamente significante. Porém, na análise das médias de acertos observou-se a tendência do pior desempenho do GE em comparação ao GR, em todas as tarefas. Existe uma diferença estatisticamente significante no desempenho de tarefas de CF (segmentação silábica em dissílabas, trissílabas e quadrissílabas; detecção silábica inicial e final; reversão silábica em dissílabas; detecção de fonemas inicial e final; síntese fonêmica com 3, 4, 5 e 6 fonemas entre crianças com desenvolvimento de fala normal e crianças com DFE. CONCLUSÕES: na análise geral dos dados as crianças com DFE obtiveram pior desempenho nas tarefas de CF do que as crianças com desenvolvimento de fala normal. Somado ao pior desempenho, as crianças do GE também não conseguiram realizar as tarefas de reversão e segmentação fonêmica.PURPOSE: to compare the performance in the metaphonological skills at the level of syllabic and phonemic awareness, among children with normal development of speech and children with evolutional phonological disorder (EFD, aged 4 and 8 years. METHODS: 49 subjects took part in the research, being 26 of

  9. Linkage disequilibrium at the APA insecticidal seed protein locus of common bean (Phaseolus vulgaris L.).

    Science.gov (United States)

    Blair, Matthew W; Prieto, Sergio; Díaz, Lucy M; Buendía, Héctor F; Cardona, César

    2010-04-29

    An interesting seed protein family with a role in preventing insect herbivory is the multi-gene, APA family encoding the alpha-amylase inhibitor, phytohemagglutinin and arcelin proteins of common bean (Phaseolus vulgaris). Variability for this gene family exists and has been exploited to breed for insect resistance. For example, the arcelin locus has been successfully transferred from wild to cultivated common bean genotypes to provide resistance against the bruchid species Zabrotes subfasciatus although the process has been hampered by a lack of genetic tools for and understanding about the locus. In this study, we analyzed linkage disequilibrium (LD) between microsatellite markers at the APA locus and bruchid resistance in a germplasm survey of 105 resistant and susceptible genotypes and compared this with LD in other parts of the genome. Microsatellite allele diversity was found to vary with each of the eight APA-linked markers analyzed, and two markers within the APA locus were found to be diagnostic for bruchid resistance or susceptibility and for the different arcelin alleles inherited from the wild accessions. Arc1 was found to provide higher levels of resistance than Arc5 and the markers in the APA locus were highly associated with resistance showing that introgression of this gene-family from wild beans provides resistance in cultivated beans. LD around the APA locus was found to be intermediate compared to other regions of the genome and the highest LD was found within the APA locus itself for example between the markers PV-atct001 and PV-ag004. We found the APA locus to be an important genetic determinant of bruchid resistance and also found that LD existed mostly within the APA locus but not beyond it. Moderate LD was also found for some other regions of the genome perhaps related to domestication genes. The LD pattern may reflect the introgression of arcelin from the wild into the cultivated background through breeding. LD and association studies for

  10. The influence of U-2 fraction of a tortoise spleen extract on the formation of ectopic locus of haemopoiesis

    International Nuclear Information System (INIS)

    Turdyev, A.A.; Prus, E.K.; Basova, A.R.

    1990-01-01

    The implantation of a bone marrow fragment of intact mouse donors below the kidney capsule of irradiated (7 Gy) recipients leads to the formation of the haemopoiesis locus that somewhat exceeds, by mass and cellularity, the new-formed locus of control animals. The U-2 fraction of a tortoise spleen extract administered to recipients irradiated with the same dose increases the mass and cellularity of the haemopoiesis locus by 2.2 and 4.9 times respectively

  11. The valve of CT in diagnosing the invasive and non-invasive thymoma

    International Nuclear Information System (INIS)

    Tang Wenyan; Jiang Kuiming; Song Ting; Lin Wenjian; Chen Zhanhang

    2009-01-01

    Objective: To Study CT features of thymoma and its value in differentiating the invasive from non-invasive thymoma. Methods: CT findings of 17 cases with thymoma (11 non-invasive and 6 invasive) confirmed by surgery and pathology were analyzed retrospectively. Results: 11 cases were non-invasive thymoma. On CT, the tumors were round or oval in 6 cases, lobulate in 4 cases, and irregular in 1 case. The lesions showed homogeneous density and mild enhancement in 9 cases. 10 of them showed complete capsules without invasion. The mass-cardiovascular interface was: convex type in 5 cases, flat type in 3 cases and concave type in 2 cases. 6 cases were invasive thymoma, tumors were irregular and heterogeneous in 5 cases. Significant and inhomogeneous enhancement on post contrast CT was found. Conclusion: The CT features of thymoma was specific, and CT is of great value in differentiating the invasive from non-invasive thymoma. (authors)

  12. Does cognitive training improve internal locus of control among older adults?

    Science.gov (United States)

    Wolinsky, Fredric D; Vander Weg, Mark W; Martin, René; Unverzagt, Frederick W; Willis, Sherry L; Marsiske, Michael; Rebok, George W; Morris, John N; Ball, Karlene K; Tennstedt, Sharon L

    2010-09-01

    We evaluated the effect of cognitive training among 1,534 participants in the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) randomized controlled trial (RCT) on 5-year improvements in 3 cognitive-specific measures of locus of control-internal, chance, and powerful others. ACTIVE was a multisite RCT (age > or = 65), with 4 groups (memory, reasoning, speed of processing, and no-contact control). Complete 5-year follow-up data were available for 1,534 (55%) of the 2,802 participants. A propensity score model was used to adjust for potential attrition bias. Clinically important improvements (and decrements) in the cognitive-specific locus of control scale scores were defined as greater than or equal to 0.5 SD (medium) and greater than or equal to 1.0 SD (large). Multinomial logistic regression was used to simultaneously contrast those who improved and those who declined with those whose locus of control scale score was unchanged. Statistically significant effects reflecting medium-sized (> or = 0.5 SD) improvements in internal locus of control between baseline and the 5-year follow-up were found for the reasoning and speed of processing intervention groups who were 76% (p control group. No improvement effects were found on the chance or powerful others locus of control measures or for the memory intervention group. Cognitive training that targets reasoning and speed of processing can improve the cognitive-specific sense of personal control over one's life in older adults.

  13. Root locus analysis and design of the adaptation process in active noise control.

    Science.gov (United States)

    Tabatabaei Ardekani, Iman; Abdulla, Waleed H

    2012-10-01

    This paper applies root locus theory to develop a graphical tool for the analysis and design of adaptive active noise control systems. It is shown that the poles of the adaptation process performed in these systems move on typical trajectories in the z-plane as the adaptation step-size varies. Based on this finding, the dominant root of the adaptation process and its trajectory can be determined. The first contribution of this paper is formulating parameters of the adaptation process root locus. The next contribution is introducing a mechanism for modifying the trajectory of the dominant root in the root locus. This mechanism creates a single open loop zero in the original root locus. It is shown that appropriate localization of this zero can cause the dominant root of the locus to be pushed toward the origin, and thereby the adaptation process becomes faster. The validity of the theoretical findings is confirmed in an experimental setup which is implemented using real-time multi-threading and multi-core processing techniques.

  14. Oscillating Evolution of a Mammalian Locus with Overlapping Reading Frames: An XLalphas/ALEX Relay.

    Directory of Open Access Journals (Sweden)

    2005-08-01

    Full Text Available XLalphas and ALEX are structurally unrelated mammalian proteins translated from alternative overlapping reading frames of a single transcript. Not only are they encoded by the same locus, but a specific XLalphas/ALEX interaction is essential for G-protein signaling in neuroendocrine cells. A disruption of this interaction leads to abnormal human phenotypes, including mental retardation and growth deficiency. The region of overlap between the two reading frames evolves at a remarkable speed: the divergence between human and mouse ALEX polypeptides makes them virtually unalignable. To trace the evolution of this puzzling locus, we sequenced it in apes, Old World monkeys, and a New World monkey. We show that the overlap between the two reading frames and the physical interaction between the two proteins force the locus to evolve in an unprecedented way. Namely, to maintain two overlapping protein-coding regions the locus is forced to have high GC content, which significantly elevates its intrinsic evolutionary rate. However, the two encoded proteins cannot afford to change too quickly relative to each other as this may impair their interaction and lead to severe physiological consequences. As a result XLalphas and ALEX evolve in an oscillating fashion constantly balancing the rates of amino acid replacements. This is the first example of a rapidly evolving locus encoding interacting proteins via overlapping reading frames, with a possible link to the origin of species-specific neurological differences.

  15. LocusTrack: Integrated visualization of GWAS results and genomic annotation.

    Science.gov (United States)

    Cuellar-Partida, Gabriel; Renteria, Miguel E; MacGregor, Stuart

    2015-01-01

    Genome-wide association studies (GWAS) are an important tool for the mapping of complex traits and diseases. Visual inspection of genomic annotations may be used to generate insights into the biological mechanisms underlying GWAS-identified loci. We developed LocusTrack, a web-based application that annotates and creates plots of regional GWAS results and incorporates user-specified tracks that display annotations such as linkage disequilibrium (LD), phylogenetic conservation, chromatin state, and other genomic and regulatory elements. Currently, LocusTrack can integrate annotation tracks from the UCSC genome-browser as well as from any tracks provided by the user. LocusTrack is an easy-to-use application and can be accessed at the following URL: http://gump.qimr.edu.au/general/gabrieC/LocusTrack/. Users can upload and manage GWAS results and select from and/or provide annotation tracks using simple and intuitive menus. LocusTrack scripts and associated data can be downloaded from the website and run locally.

  16. PENGARUH TEKANAN ANGGARAN WAKTU, LOCUS OF CONTROL DAN KOMITMEN PROFESIONAL PADA PERILAKU PENURUNAN KUALITAS AUDIT

    Directory of Open Access Journals (Sweden)

    NI Wayan Wiwin Intan Wintari

    2016-02-01

    Full Text Available The Impact of Time Budget Pressure, Locus of Control and Professional Commitment on the Reduction of Audit Quality Behavior. Reduced audit quality behavior is a serious threat to the auditing profession. Auditing cases, such as Enron Corporation and Worldcom have made the audit rofession to be the public spotlight, which makes the credibility of the auditors increasingly questionable. This study aimed to examine the factors that can cause reduced audit quality behavior such as time budget pressure, locus of control and professional commitment.  The research used questionnaire that was distributed to 70 auditors of BPKP Representative of Bali Province. Method of determining the sample was saturated sampling. The data analysis was conducted by multiple linear regressions, and the results showed that the time budget pressure and external locus of control has a positive influence on reduced audit quality behavior, while internal locus of control and professional commitment have negative effect.   Keywords:  reduced audit quality behavior, time budget pressure, locus of control, professional commitment

  17. Premenstrual symptomatology, locus of control, anxiety and depression in women with normal menstrual cycles.

    Science.gov (United States)

    Lane, T; Francis, A

    2003-04-01

    The present study was designed to investigate the relationships between premenstrual symptomatology, locus of control, anxiety, and depression in women with normal menstrual cycles. Sixty-nine female participants completed a survey, comprised of the Menstrual Distress Questionnaire (MDQ; Moos, 1968), Levenson's (1981) locus of control scales, the Depression Anxiety Stress Scale (DASS; Lovibond and Lovibond, 1995), and a questionnaire constructed by the researchers based on the DSM-IV criteria for Premenstrual Dysphoric Disorder (PMDD). Both overall and specific subtypes of premenstrual symptomatology were found to correlate with external locus of control, anxiety, and depression. In addition, locus of control was found to moderate the relationship between premenstrual symptomatology, anxiety and depression. Finally, women who were in the premenstrual phase when completing the questionnaire scored significantly lower on the internal scale than those in either the follicular or early luteal phases. It was concluded that an external locus of control may be associated with a susceptibility to depression or anxiety when certain premenstrual or postmenstrual changes are experienced.

  18. Composición del locus de control en dos ciudades latinoamericanas

    Directory of Open Access Journals (Sweden)

    Jesús Francisco Laborín Álvarez

    2008-01-01

    Full Text Available El locus de control es un rasgo de personalidad vinculado con la atribución que hacen los individuos acerca de sus éxitos y fracasos. Los estudios en diferentes naciones y sociedades han demostrado que existen características generales y particulares respecto a la percepción de control y donde la cultura juega un papel importante. Se partió del objetivo de conocer la composición factorial del locus de control en dos poblaciones, Hermosillo, Sonora (México (n=600 y João Pessoa, Paraíba (Brasil (n=600; y establecer las diferencias en cuanto a dicho constructo en ambas poblaciones con respecto a las variables atributivas: edad, escolaridad, ocupación y ciudad. Los resultados revelan tres dimensiones comunes a las dos poblaciones: locus de control interno, locus de control afiliativo y locus de control externo. Los datos en general hacen ver que las muestras poblacionales de las ciudades hacen juicios de control en relación a los esfuerzos y el trabajo personal, en la afiliación a colectivos y grupos de interés como los fundamentos de explicación para éxitos y fracasos.

  19. Comparing Locus of Control, Assertiveness and General Health among Young Drug Addicts in Iran

    Directory of Open Access Journals (Sweden)

    Shahriar Shahidi

    2009-04-01

    Full Text Available "n "nObjective:The aim of this research was to compare the characteristics of assertiveness, locus of control and general health among young drug dependent patients in Iran. "n "nMethods: Three groups of Iranians: were choosed. The first group included drug dependent patients who had volunteered for treatment and had registered in the local Welfare Organization; the second group included dependent patients who were in the prison; and the third group held nondependent patients. All the participants were male and were matched for age and educational level . The following instruments were used in the present study: locus of control  uestionnaire , Assertiveness Scale and the General Health Questionnaire, GHQ. "n "nResults: The results of the present research showed that there were significant differences among the three groups in ssertiveness, locus of control and GHQ scores. It was found that participants in the non addictive group were more assertive and more internal in their locus of control and had higher GHQ scores than the other two groups. The participants in the prison group reported less assertiveness and lower GHQ scores than the non addictive group ; and their locus of control was more external. Conclusion: "n The results this study may be useful in terms of possible strategies for changing an attributive style in young adults in the framework of psychotherapy

  20. Identification of a novel locus for a USH3 like syndrome combined with congenital cataract

    DEFF Research Database (Denmark)

    Dad, S.; Østergaard, Elsebet; Thykjær, T.

    2010-01-01

    Usher syndrome (USH) is the most common genetic disease that causes both deafness and blindness. USH is divided into three types, USH1, USH2 and USH3, depending on the age of onset, the course of the disease, and on the degree of vestibular dysfunction. By homozygosity mapping of a consanguineous...... Danish family of Dutch descent, we have identified a novel locus for a rare USH3-like syndrome. The affected family members have a unique association of retinitis pigmentosa, progressive hearing impairment, vestibular dysfunction, and congenital cataract. The phenotype is similar, but not identical...... to that of USH3 patients, as congenital cataract has not been reported for USH3. By homozygosity mapping, we identified a 7.3 Mb locus on chromosome 15q22.2-23 with a maximum multipoint LOD score of 2.0. The locus partially overlaps with the USH1 locus, USH1H, a novel unnamed USH2 locus, and the non-syndromic...