WorldWideScience

Sample records for introduction fifteen years

  1. Operational foreshock forecasting: Fifteen years after

    Science.gov (United States)

    Ogata, Y.

    2010-12-01

    We are concerned with operational forecasting of the probability that events are foreshocks of a forthcoming earthquake that is significantly larger (mainshock). Specifically, we define foreshocks as the preshocks substantially smaller than the mainshock by a magnitude gap of 0.5 or larger. The probability gain of foreshock forecast is extremely high compare to long-term forecast by renewal processes or various alarm-based intermediate-term forecasts because of a large event’s low occurrence rate in a short period and a narrow target region. Thus, it is desired to establish operational foreshock probability forecasting as seismologists have done for aftershocks. When a series of earthquakes occurs in a region, we attempt to discriminate foreshocks from a swarm or mainshock-aftershock sequence. Namely, after real time identification of an earthquake cluster using methods such as the single-link algorithm, the probability is calculated by applying statistical features that discriminate foreshocks from other types of clusters, by considering the events' stronger proximity in time and space and tendency towards chronologically increasing magnitudes. These features were modeled for probability forecasting and the coefficients of the model were estimated in Ogata et al. (1996) for the JMA hypocenter data (M≧4, 1926-1993). Currently, fifteen years has passed since the publication of the above-stated work so that we are able to present the performance and validation of the forecasts (1994-2009) by using the same model. Taking isolated events into consideration, the probability of the first events in a potential cluster being a foreshock vary in a range between 0+% and 10+% depending on their locations. This conditional forecasting performs significantly better than the unconditional (average) foreshock probability of 3.7% throughout Japan region. Furthermore, when we have the additional events in a cluster, the forecast probabilities range more widely from nearly 0% to

  2. Fifteen years experience: Egyptian metabolic lab

    Directory of Open Access Journals (Sweden)

    Ekram M. Fateen

    2014-10-01

    Conclusion: This study illustrates the experience of the reference metabolic lab in Egypt over 15 years. The lab began metabolic disorder screening by using simple diagnostic techniques like thin layer chromatography and colored tests in urine which by time updated and upgraded the methods to diagnose a wide range of disorders. This study shows the most common diagnosed inherited inborn errors of metabolism among the Egyptian population.

  3. Adult herpes simplex encephalitis: fifteen years' experience.

    Science.gov (United States)

    Riera-Mestre, Antoni; Gubieras, Laura; Martínez-Yelamos, Sergio; Cabellos, Carmen; Fernández-Viladrich, Pedro

    2009-03-01

    Herpes simplex encephalitis (HSE) is the most frequent cause of sporadic necrotizing encephalitis in adults. The aim of this study is to describe the characteristics of HSE and the factors influencing its outcome. Retrospective study of patients diagnosed with HSE in a tertiary care teaching hospital over a 15-year period. Diagnosis was based on a consistent clinical profile for HSE, plus either a PCR-positive CSF HSV study or consistent brain neuroimaging findings. Patients were divided into 2 groups according to the modified Rankin Scale: good outcome (Grades =3). Thirty-five patients were included. Mean age was 53.9 years. More than half presented febricula or fever, headache, disorientation, behavioral changes, decreased level of consciousness, or neurological deficit. CSF glucose concentration was normal in all patients and WBC count was normal in 8 (23%). PCR for HSV was positive in 92% and cranial MRI was suggestive of HSE in 100% of patients. Mortality was 8.6%. In relation to outcome, age (OR=1.079; 95% CI, 1.023-1.138) and serum albumin level at admission (OR=0.87; 95% CI, 0.794-0.954) were independent prognostic factors at discharge. At 6 months, days of fever after initiation of acyclovir therapy (OR=1.219; 95% CI, 1.046-1.422) and serum albumin level at admission (OR=0.917; 95% CI, 0.87-0.967) were independent prognostic factors. Normal brain MRI or detection of low CSF glucose concentration requires consideration of diagnoses other than HSE. Age, serum albumin level at admission, and days of fever after initiation of acyclovir therapy were independent prognostic factors of the disease.

  4. Fifteen years of radioactive waste management at Ontario Hydro

    International Nuclear Information System (INIS)

    Carter, T.J.; Rao, P.K.M.

    1985-01-01

    Ontario Hydro is a large Canadian utility producing 84% (7394 MWe) of the Nuclear Electricity generated in Canada. The low- and intermediate-level radioactive wastes generated by the Ontario Hydro program are currently being managed at the Bruce Nuclear Power Development with various volume reduction, packaging and interim storage systems. Ontario Hydro also owns and operates a radioactive waste transportation system. Studies are in progress for final disposal of these wastes in a suitable geology in Ontario. Since its inception in 1971, Ontario Hydro's radioactive waste management program has evolved into providing a full fledged radioactive waste management capability to the utility's two nuclear generation centres at Pickering and Bruce, and later in the decade, to Darlington. This paper summarizes the various developments in this program; highlights the major facilities both in-service and planned to be built; reviews the experiences gained over fifteen years of in-house waste management; and discusses the proposed reorientation towards ultimate disposal of these wastes. 2 refs., 8 figs., 1 tab

  5. Will the next fifteen years of high energy physics match the last fifteen

    International Nuclear Information System (INIS)

    Bjorken, J.D.

    1985-09-01

    A brief retrospective of advances in high energy physics made during the last 15 years, both theortical and experimental, is given, followed by predictions for future work, which is said to include testing the standard model and exploring the Higgs sector. The theoretical methods available for understanding the Higgs sector are briefly discussed, as well as available experimental tools

  6. Fifteen years of experience radical cystectomy and intestinal urinary diversion

    Directory of Open Access Journals (Sweden)

    M. I. Vasil’chenko

    2017-01-01

    Full Text Available Objective. Examination of the results of surgical treatment and analysis of the surgical technique and perioperative parameters in a series of radical cystectomy on the basis of its own 15 years of experience in the formation of orthotopic and heterotopic urinary reservoir of the ileum segment by developed and patented techniques in different versions: open radical cystectomy, laparoscopic radical cystectomy and robotassisted radical cystectomy.Materials and methods. A retrospective analysis of 310 radical cystectomy performed from 2000 to 2015, on the occasion of various pathologies of the bladder and prostate, as well as cancers of other organs (uterus, colon with involvement in the process of bladder tumor. Plastics of the bladder was performed from the segment of the terminal ileum. Formation of orthotopic bladder was performed by the method of M.I. Vasilchenko (RF patent for invention № 2337630 “Method of orthotopic bladder plastics” by M.I. Vasilchenko. The ureters are implanted by antireflux procedure. If unable to perform orthotopic bladder plastics recovery and self-urination, patients underwent the formation of heterotopic enteral reservoir with a holding valve.Results. It assesses the functionality and viability of organic shaped orthotopic and heterotopic urinary neocystis in the early and late postoperative periods in different versions. The proposed techniques have a beneficial effect on the improvement of the functional state and stabilization of the upper urinary tract. Analysis of morbidity and mortality was determined according to the classification of surgical complications on the Clavien–Dindo. This approach allowed to identify most of the complications and prevent an underestimation of the main negative results. Estimated oncologic efficacy of minimally invasive interventions laparoscopic radical cystectomy and robot-assisted radical cystectomy not inferior open radical cystectomy.Conclusions. Formation of

  7. Histology types of chest wall tumours: Fifteen year single center ...

    African Journals Online (AJOL)

    Materials and Methods: We performed a retrospective study of chest wall tumours at our institution(NCTCE, UNTH, Enugu, Nigeria), for a period of 15 years, spanning October, 2001 to September, 2015.The pathologic reports were retrieved from the hospital pathology archives and correlated with patients' copies in the ...

  8. Fifteen years experience: Egyptian metabolic lab | Fateen | Egyptian ...

    African Journals Online (AJOL)

    Those patients were classified as: 722 patients (69.4%) with lysosomal storage disorders, 302 patients (29%) with amino acid disorders and 17 patients (1.6%) with galactosemia. Conclusion: This study illustrates the experience of the reference metabolic lab in Egypt over 15 years. The lab began metabolic disorder ...

  9. The history of Korean Institute Chemical Engineers for fifteen years

    International Nuclear Information System (INIS)

    2012-12-01

    This book reports the history of Korean Institute of Chemical Engineers with commemorative message, three congratulatory address and photos for fifty years. Nest, it consists of five chapters, which deals with development this institute by chronological classification. It reports the development history by activity such as education, research, publishing branch, international activity, data, woman, and executive office. It records challenge of chemical engineering, remembrance for past presidents and appendixes on history and a list of members.

  10. [Ankylosing spondylitis in Shantou: clinical experience in fifteen years].

    Science.gov (United States)

    Zeng, Q; Chen, S; Xu, J; Xiao, Z; Lin, L; Liu, Y; Huang, S; Xie, S

    1999-07-01

    To evaluate the clinical features of ankylosing spondylitis (AS) in Shantou area and improve the diagnostic level and therapeutic effect. Clinical and laboratory data, and the methods and effects of therapy were analyzed. Some patients were followed up. 94% of the cases had an insidious onset. Low back pain or discomfort, peripheral arthritis, positive "4" test and pressing tenderness over the sacroiliac joints and lumbar spine were the frequent symptoms and signs. The degree of sacroiliitis and involvement of hip and spine were related to the disease duration. However, hip joint involvement in juvenile onset AS did not relate to the disease duration. Some cases with disease duration as long as 16 years still remained at II of degree sacroiliitis. Clinical improvement was more obvious in the first two years of treatment. Although some patients came to a standstill condition after this period, yet the disease activity might still relapse with withdrawal of the treatment. The rate of adhering to the treatment for 1, 2, and over 5 years was 34.6%, 28.4%, and 10.3% respectively. The radiological changes frequently did not parallel with the clinical manifestations. Early diagnosis is of importance in improving the prognosis of AS and adherence to slow-acting anti-rheumatic drug therapy is beneficial in disease controlling. A follow up of more than 3 years is necessary to estimate the therapeutic efficacy, and the radiological change is the key indicator. AS is a heterogenic disease and the risk factors for prognosis should be further studied.

  11. The history of Korean Institute Chemical Engineers for fifteen years

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-12-15

    This book reports the history of Korean Institute of Chemical Engineers with commemorative message, three congratulatory address and photos for fifty years. Nest, it consists of five chapters, which deals with development this institute by chronological classification. It reports the development history by activity such as education, research, publishing branch, international activity, data, woman, and executive office. It records challenge of chemical engineering, remembrance for past presidents and appendixes on history and a list of members.

  12. Fifteen Years of ASTER Data on NASA's Terra Platform

    Science.gov (United States)

    Abrams, M.; Tsu, H.

    2014-12-01

    The Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) is one of five instruments operating on NASA's Terra platform. Launched in 1999, ASTER has been acquiring data for 15 years. ASTER is a joint project between Japan's Ministry of Economy, Trade and Industry; and US NASA. Data processing and distribution are done by both organizations; a joint science team helps to define mission priorities. ASTER acquires ~550 images per day, with a 60 km swath width. A daytime acquisition is three visible bands and a backward-looking stereo band with 15 m resolution, six SWIR bands with 30 m resolution, and 5 TIR bands with 90 m resolution. Nighttime TIR-only data are routinely collected. The stereo capability has allowed the ASTER project to produce a global Digital Elevation Model (GDEM) data set, covering the earth's land surfaces from 83 degrees north to 83 degrees south, with 30 m data postings. This is the only (near-) global DEM available to all users at no charge; to date, over 28 million 1-by-1 degree DEM tiles have been distributed. As a general-purpose imaging instrument, ASTER-acquired data are used in numerous scientific disciplines, including: land use/land cover, urban monitoring, urban heat island studies, wetlands studies, agriculture monitoring, forestry, etc. Of particular emphasis has been the acquisition and analysis of data for natural hazard and disaster applications. We have been systematically acquiring images for 15,000 valley glaciers through the USGS Global Land Ice Monitoring from Space Project. The recently published Randolph Glacier Inventory, and the GLIMS book, both relied heavily on ASTER data as the basis for glaciological and climatological studies. The ASTER Volcano Archive is a unique on-line archive of thousands of daytime and nighttime ASTER images of ~1500 active glaciers, along with a growing archive of Landsat images. ASTER was scheduled to target active volcanoes at least 4 times per year, and more frequently for

  13. Proteomics Standards Initiative: Fifteen Years of Progress and Future Work.

    Science.gov (United States)

    Deutsch, Eric W; Orchard, Sandra; Binz, Pierre-Alain; Bittremieux, Wout; Eisenacher, Martin; Hermjakob, Henning; Kawano, Shin; Lam, Henry; Mayer, Gerhard; Menschaert, Gerben; Perez-Riverol, Yasset; Salek, Reza M; Tabb, David L; Tenzer, Stefan; Vizcaíno, Juan Antonio; Walzer, Mathias; Jones, Andrew R

    2017-12-01

    The Proteomics Standards Initiative (PSI) of the Human Proteome Organization (HUPO) has now been developing and promoting open community standards and software tools in the field of proteomics for 15 years. Under the guidance of the chair, cochairs, and other leadership positions, the PSI working groups are tasked with the development and maintenance of community standards via special workshops and ongoing work. Among the existing ratified standards, the PSI working groups continue to update PSI-MI XML, MITAB, mzML, mzIdentML, mzQuantML, mzTab, and the MIAPE (Minimum Information About a Proteomics Experiment) guidelines with the advance of new technologies and techniques. Furthermore, new standards are currently either in the final stages of completion (proBed and proBAM for proteogenomics results as well as PEFF) or in early stages of design (a spectral library standard format, a universal spectrum identifier, the qcML quality control format, and the Protein Expression Interface (PROXI) web services Application Programming Interface). In this work we review the current status of all of these aspects of the PSI, describe synergies with other efforts such as the ProteomeXchange Consortium, the Human Proteome Project, and the metabolomics community, and provide a look at future directions of the PSI.

  14. Ectopic pregnancy: current clinical trends, a fifteen year study.

    Science.gov (United States)

    Weekes, L R

    1981-09-01

    This paper reviews the clinical recognition, diagnosis, and management of ectopic pregnancy at the Queen of Angels Hospital for the past 15 years. The incidence of ectopic pregnancy to deliveries is 1:195. Pain is the cardinal symptom of ectopic pregnancy, and amenorrhea of some degree was present in all cases. Pelvic inflammatory disease is a factor in the development of tubal pregnancy in some women. A careful history and thorough physical examination are important in making a careful diagnosis. The only laboratory procedures which are of any value are the blood type and the Rh determination. While examination of endometrial tissue obtained by biopsy or curettage has proved useful in ectopic pregnancy diagnosis, it is not totally decisive. Culdocentesis has proved to be the diagnostic procedure of the greatest value in recognizing intraperitoneal hemorrhage and it increases the correct preoperative diagnosis from 65-70% to 95%. Laparoscopy is useful when the physician is in doubt about the nature of the problem and it has produced an increase in the number of ectopic pregnancies diagnosed. Ultrasound is another useful tool in confirming a diagnosis of ectopic pregnancy; its accuracy ranges from 70-92%. A newly developed pregnancy test is more sensitive than conventional pregnancy tests and would be positive for pregnancy. Women who have had a previous ectopic pregnancy have a higher subsequent incidence of persistent infertility, recurrent ectopic pregnancy, and pregnancy wastage; the risk of another ectopic pregnancy increases 30-50 fold. While extopic pregnancy does recur, it is true that about 1/3 of those women do have successful pregnancies. Where previous induced abortion has occurred, there is a 10-fold increased risk of ectopic pregnancy. Women who become pregnant accidentally with an IUD in place have a greater likelihood of experiencing an extrauterine pregnancy. Abdominal pregnancy is often encountered as an aborting ectopic pregnancy during the 1st

  15. DMPD: NF-kappaB activation by reactive oxygen species: fifteen years later. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 16723122 NF-kappaB activation by reactive oxygen species: fifteen years later. Gloi...svg) (.html) (.csml) Show NF-kappaB activation by reactive oxygen species: fifteen years later. PubmedID 167...23122 Title NF-kappaB activation by reactive oxygen species: fifteen years later.

  16. The Lost Art of Regulated tolerance? Fifteen Years of Regulating Vices in Amsterdam

    NARCIS (Netherlands)

    Huisman, W.; Nelen, J.M.

    2014-01-01

    Fifteen years ago, Brants explored the idiosyncrasies of Dutch policy with regard to prostitution, focusing on the situation in the Dutch capital. Amsterdam was on the brink of the enactment of new policies and legislation regarding the legalization of prostitution and the crackdown on organized

  17. Physical activity levels and patterns of thirteen to fifteen year old ...

    African Journals Online (AJOL)

    There is worldwide concern over the decline in physical activity (PA) levels among school children. The purpose of this study was to investigate the (PA) levels and PA patterns of thirteen to fifteen year old boys from different race groups in the North- West Province and to determine to what degree this physical activity profile ...

  18. Development and use of a fifteen year-old equivalent mathematical phantom for internal dose calculations

    International Nuclear Information System (INIS)

    Jones, R.M.; Poston, J.W.; Hwang, J.L.; Jones, T.D.; Warner, G.G.

    1976-06-01

    The existence of a phantom based on anatomical data for the average fifteen-year-old provides for a proficient means of obtaining estimates of absorbed dose for children of that age. Dimensions representative of an average fifteen-year-old human, obtained from various biological and medical research, were transformed into a mathematical construct of idealized shapes of the exterior, skeletal system, and internal organs of a human. The idealization for an average adult presently in use by the International Commission on Radiological Protection was used as a basis for design. The mathematical equations describing the phantom were developed to be readily adaptable to present-day methods of dose estimation. Typical exposure situations in nuclear medicine have previously been modeled for existing phantoms. With no further development of the exposure model necessary, adaptation to the fifteen-year-old phantom demonstrated the utility of the design. Estimates of absorbed dose were obtained for the administration of two radiopharmaceuticals, /sup 99m/Tc-sulfur colloid and /sup 99m/Tc-DMSA

  19. Co-occurrence of Marfan syndrome and bipolar disorder: A fifteen year follow up.

    Science.gov (United States)

    Jha, Vijendra Nath; Kumar, Manoj; Tarwani, Jatin

    2016-12-01

    Marfan syndrome, a chromosomal disorder, has been commonly associated with schizophrenia but no association with Bipolar affective disorder has been reported in the scientific literature. This case depicts the occurrence of Bipolar affective disorder in a previously undiagnosed case of Marfan syndrome. In this case patient had all manic episodes without any depressive or schizophrenia-like episodes, suggesting a diagnostic stability over a long period of over fifteen years. Studies and research are needed in this regard to look for any possible potential association between the two illnesses. Copyright © 2016 Elsevier B.V. All rights reserved.

  20. Expertise and politics crisis: lessons learned from fifteen years of negotiations on climate change

    International Nuclear Information System (INIS)

    Hourcade, J.Ch.

    2003-01-01

    The author proposes some analyses and comments about the relationships between experts who have been involved in various conferences and meetings (from Rio de Janeiro in 1992 to Marrakech in 2002) on climate change. He presents the different groups of experts and comments the issues which have been a matter of debate between them for the past fifteen years. For each of these issues, he gives an overview of the expertise status, highlights consensus as well as dissensus. He compares this expertise with the content of political discourses, and then shows which mechanisms led to The Hague failure and to the incomplete Marrakech's compromise

  1. Fifteen year's research activities of the INSS Institute of Nuclear Technology and future policy

    International Nuclear Information System (INIS)

    Kimura, Itsuro

    2008-01-01

    Fifteen years have passed since the Institute of Nuclear Safety System, Incorporated (INSS) was founded. This paper reviews the research activities of the Institute of Nuclear Technology in INSS over that time and proposes a policy for future research. First, a chronological table shows the major milestones over the past fifteen years. Notable events include the following. The head office was moved to Mihama-cho where laboratories and experimental facilities were installed; the Institute signed an agreement with the Kansai Electric Power Co., Inc. (KEPCO) on assistance for the preparedness of nuclear emergency; it assisted KEPCO to investigate the causes of the accident at its Mihama Nuclear Power Station Unit 3 and subsequently established the Nuclear Power Plant Aging Research Center, it began providing information on adverse events occurred at nuclear power plants in the world to Japanese electric utilities that own PWRs; it supported the Energy Research and Development Centralization Plan of Fukui Prefecture, and it embarked on a project to develop the Fukui regional cluster in the Fukui and Kinki area under the government's program for aging management of nuclear power plants. The fifteen years of research activities are shown for each research group and for each research project, and then important achievements of the major research projects are described. Finally, the status of research papers published in external Journals and in INSS over the past fifteen years is illustrated and the number of patents acquired during this period is presented. We evaluated our research activities over the fifteen years and reviewed them according to seven items under a future research policy. The plans include the enhancement of system engineering-based research efforts as the name of this Institute implies, and committing ourselves to forward-looking and creative research program focusing on not only from analysis', but also on 'synthesis'. A suitable approach to safety

  2. A historical perspective on fifteen years of laser damage thresholds at LLNL

    International Nuclear Information System (INIS)

    Rainer, F.; De Marco, F.P.; Staggs, M.C.; Kozlowski, M.R.; Atherton, L.J.; Sheehan, L.M.

    1993-01-01

    We have completed a fifteen year, referenced and documented compilation of more than 15,000 measurements of laser-induced damage thresholds (LIDT) conducted at the Lawrence Livermore National Laboratory (LLNL). These measurements cover the spectrum from 248 to 1064 nm with pulse durations ranging from < 1 ns to 65 ns and at pulse-repetition frequencies (PRF) from single shots to 6.3 kHz. We emphasize the changes in LIDTs during the past two years since we last summarized our database. We relate these results to earlier data concentrating on improvements in processing methods, materials, and conditioning techniques. In particular, we highlight the current status of anti-reflective (AR) coatings, high reflectors (HR), polarizers, and frequency-conversion crystals used primarily at 355 nm and 1064 nm

  3. Beijing fifteen years on: the persistence of barriers to gender mainstreaming in health policy.

    Science.gov (United States)

    Payne, Sarah

    2011-01-01

    In 2010, fifteen years after the Beijing declaration on women's rights, the UN Commission on the Status of Women met to review progress in gender mainstreaming. Reports on gender equality by member states revealed differences in the degree of change achieved in this period, while highlighting common barriers to gender mainstreaming. The same barriers have long been identified by academics and activists, but prove remarkably resistant to strategies to address gender inequalities. This paper reviews approaches to gender mainstreaming in the context of health policy, and suggests that a model of the obstacles to gender mainstreaming, which identifies barriers as essentially pragmatic, conceptual, or political in origin, might enable a more explicit discussion of the factors underlying this resistance and the ways in which they might be challenged.

  4. Surgical Treatment of the Giant Leiyomyoma of the Esophagus After Fifteen Years

    Directory of Open Access Journals (Sweden)

    Mehmet Bilgin

    2015-11-01

    Full Text Available Leiyomyomas are benign intramural tumors of esophagus which are rarely seen. Nearly half of the patients are asymptomatic because leiyomyomas grow slowly and intramural. Dysphagia and retrosternal pain are the most common symptoms.Osephagus leiyomyomas may appear as mediastinal mass in chest radiography and may be recognised by coincidence. It is known that they are solitary, round or oval, and their diameter may reach 15-17cm size. When it grows up to the giant diamaters, surgery is the choice of treatment. Because tumors covering distal part of esophagus and cardia are ulcerated and adhesive to mucosa resection, esophagogastric anasthomosis may be required. We are presenting the clinical and radiologic findings of this giant leiyoma case who did not accept surgical treatment fifteen years ago, and whose leiomyoma reached up to a big diamater.

  5. Fifteen-year Experience with Telemedicine Services in Gangwon Province in Korea

    Science.gov (United States)

    Kim, Hyung-Gi; Choi, Young-A; Choi, Eun-Hi; Kim, Dong-Won; Shin, Se-Gye; Park, Kyung-Suk; Han, Jae-Hyun

    2015-01-01

    Objectives This study attempted to identify the factors that contribute to successful telemedicine service. This was done by analyzing the operational state of successful telemedicine services offered in Gangwon Province of Korea and their outcome for the last fifteen years. Methods A comparative analysis was made based on reports and a thesis on the satisfaction rate of patients and providers, patient compliance to treatment, and economic assessment of Gangwon telemedicine service, which were carried out in three periods: the years 2006, 2010, and 2012. Results The satisfaction surveys in all three periods showed similar results for patients (4.46±0.70 point) and healthcare practitioners, including nurses (3.82±0.62 point) and physicians (3.60±0.56 point), in decreasing order from the year 2012. Through the survey of patients' compliance with treatment, it was confirmed that telemedicine services increased patients' compliance with drug administration, facilitated improvement of lifestyle habits, improved glycated hemoglobin for patients with diabetes mellitus, and enhanced the rate of blood pressure control. In the survey conducted on patients' willingness to pay for telemedicine services in 2007, it was found that those patients were willing to pay about $3.5 for services. Conclusions The telemedicine services of Gangwon Province increased patients' compliance with drug administration, improved blood glucose control, enhanced blood pressure control for patients with hypertension, and provided economic advantage. PMID:26618035

  6. Fifteen years of GH replacement improves body composition and cardiovascular risk factors.

    Science.gov (United States)

    Elbornsson, Mariam; Götherström, Galina; Bosæus, Ingvar; Bengtsson, Bengt-Åke; Johannsson, Gudmundur; Svensson, Johan

    2013-05-01

    Few studies have determined the effects of more than 5-10 years of GH replacement in adults on body composition and cardiovascular risk factors. In this prospective, single-center, open-label study, the effects of 15 years of GH replacement on body composition and cardiovascular risk factors were determined in 156 hypopituitary adults (93 men) with adult-onset GH deficiency (GHD). Mean age was 50.5 (range 22-74) years at study start. Body composition was measured using dual-energy X-ray absorptiometry. The mean initial GH dose of 0.55 (S.E.M. 0.03) mg/day was gradually lowered to 0.40 (0.01) mg/day after 15 years. The mean serum IGF1 SDS increased from -1.53 (0.10) at baseline to 0.74 (0.13) at study end (Plevel at study end (Pbody fat (BF) started to increase and had returned to the baseline level after 15 years. Serum levels of total cholesterol and LDL-cholesterol decreased and serum HDL-cholesterol level increased. Fasting plasma glucose increased from 4.4 (0.1) at baseline to 4.8 (0.1) mmol/l at study end (P<0.001). However, blood HbA1c decreased from 5.0 (0.1) to 4.6 (0.1) % (P<0.001). Fifteen-year GH replacement in GHD adults induced a transient decrease in BF and sustained improvements of LST and serum lipid profile. Fasting plasma glucose increased whereas blood HbA1c was reduced.

  7. Atypical presentation of Legionella pneumonia among patients with underlying cancer: A fifteen-year review.

    Science.gov (United States)

    del Castillo, Maria; Lucca, Anabella; Plodkowski, Andrew; Huang, Yao-Ting; Kaplan, Janice; Gilhuley, Kathleen; Babady, N Esther; Seo, Susan K; Kamboj, Mini

    2016-01-01

    Immunocompromised patients, especially those receiving treatment with corticosteroids and cytotoxic chemotherapy are at increased risk for developing Legionella pneumonia. The aim of this study was to determine clinical and radiographic characteristics of pulmonary infection due to Legionella in persons undergoing treatment for cancer and stem cell transplant (SCT) recipients. Retrospective review of Legionella cases at MSKCC over a fifteen-year study period from January 1999 and December 2013. Cases were identified by review of microbiology records. During the study period, 40 cases of Legionella infection were identified; nine among these were due to non-pneumophila species. Most cases occurred during the summer. The majority [8/9, (89%)] of patients with non-pneumophila infection had underlying hematologic malignancy, compared to 18/31 (58%) with Legionella pneumophila infections. Radiographic findings were varied-nodular infiltrates mimicking invasive fungal infection were seen only among patients with hematologic malignancy and hematopoietic stem cell transplant (SCT) recipients and were frequently associated with non-pneumophila infections (50% vs 16%; P = 0.0594). All cases of nodular Legionella pneumonia were found incidentally or had an indolent clinical course. Legionella should be considered in the differential diagnosis of nodular lung lesions in immunocompromised patients, especially those with hematologic malignancy and SCT recipients. Most cases of nodular disease due to Legionella are associated with non-pneumophila infections. Copyright © 2015 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

  8. Purity, Victimhood and Agency: Fifteen years of the UN Trafficking Protocol

    Directory of Open Access Journals (Sweden)

    Marjan Wijers

    2015-04-01

    Full Text Available When the women’s movement reverted back to the nineteenth-century Victorian concept of ‘trafficking in women’ to address abuses of migrant women in the sex industry, it unwittingly adopted not only a highly morally biased concept—dividing women into innocent victims in need of rescue and guilty ones who can be abused with impunity—but also one with racist and nationalistic overtones. Despite efforts to counter these flaws, this inheritance continues to define the debate on trafficking today, exemplified by the distinction made by the United Nations Trafficking Protocol between so-called ‘sexual exploitation’ and ‘labour exploitation’ and its focus on the aspects of recruitment and movement. As a result, its implementation in the last fifteen years has led to a range of oppressive measures against sex workers and migrants in the name of combating trafficking. The focus on the purity and victimhood of women, coupled with the protection of national borders, not only impedes any serious effort to address the exploitation of human beings under forced labour and slavery-like conditions, but actually causes harm. The call of the anti-trafficking movement for a human rights-based approach does not necessarily solve these fundamental problems, as it tends to restrict itself to protecting the rights of trafficked persons, while neglecting or even denying the human rights of sex workers and migrants.

  9. Characterising fifteen years of continuous atmospheric radon activity observations at Cape Point (South Africa)

    Science.gov (United States)

    Botha, R.; Labuschagne, C.; Williams, A. G.; Bosman, G.; Brunke, E.-G.; Rossouw, A.; Lindsay, R.

    2018-03-01

    This paper describes and discusses fifteen years (1999-2013) of continuous hourly atmospheric radon (222Rn) monitoring at the coastal low-altitude Southern Hemisphere Cape Point Station in South Africa. A strong seasonal cycle is evident in the observed radon concentrations, with maxima during the winter months, when air masses arriving at the Cape Point station from over the African continental surface are more frequently observed, and minima during the summer months, when an oceanic fetch is predominant. An atmospheric mean radon activity concentration of 676 ± 2 mBq/m3 is found over the 15-year record, having a strongly skewed distribution that exhibits a large number of events falling into a compact range of low values (corresponding to oceanic air masses), and a smaller number of events with high radon values spread over a wide range (corresponding to continental air masses). The mean radon concentration from continental air masses (1 004 ± 6 mBq/m3) is about two times higher compared to oceanic air masses (479 ± 3 mBq/m3). The number of atmospheric radon events observed is strongly dependent on the wind direction. A power spectral Fast Fourier Transform analysis of the 15-year radon time series reveals prominent peaks at semi-diurnal, diurnal and annual timescales. Two inter-annual radon periodicities have been established, the diurnal 0.98 ± 0.04 day-1 and half-diurnal 2.07 ± 0.15 day-1. The annual peak reflects major seasonal changes in the patterns of offshore versus onshore flow associated with regional/hemispheric circulation patterns, whereas the diurnal and semi-diurnal peaks together reflect the influence of local nocturnal radon build-up over land, and the interplay between mesoscale sea/land breezes. The winter-time diurnal radon concentration had a significant decrease of about 200 mBq/m3 (17%) while the summer-time diurnal radon concentration revealed nearly no changes. A slow decline in the higher radon percentiles (75th and 95th) for the

  10. A Fifteen Year Record of Global Natural Gas Flaring Derived from Satellite Data

    International Nuclear Information System (INIS)

    Elvidge, Ch. D.; Erwin, E. H.; Ziskin, D.; Baugh, K. E.; Tuttle, B. T.; Ghosh, T.; Tuttle, B. T.; Ghosh, T.; Pack, D. W.; Zhizhin, M.

    2009-01-01

    We have produced annual estimates of national and global gas flaring and gas flaring efficiency from 1994 through 2008 using low light imaging data acquired by the Defense Meteorological Satellite Program (DMSP). Gas flaring is a widely used practice for the disposal of associated gas in oil production and processing facilities where there is insufficient infrastructure for utilization of the gas (primarily methane). Improved utilization of the gas is key to reducing global carbon emissions to the atmosphere. The DMSP estimates of flared gas volume are based on a calibration developed with a pooled set of reported national gas flaring volumes and data from individual flares. Flaring efficiency was calculated as the volume of flared gas per barrel of crude oil produced. Global gas flaring has remained largely stable over the past fifteen years, in the range of 140 to 170 billion cubic meters (BCM). Global flaring efficiency was in the seven to eight cubic meters per barrel from 1994 to 2005 and declined to 5.6 m 3 per barrel by 2008. The 2008 gas flaring estimate of 139 BCM represents 21% of the natural gas consumption of the USA with a potential retail market value of 68 billions USD. The 2008 flaring added more than 278 million metric tons of carbon dioxide equivalent (CO 2e ) into the atmosphere. The DMSP estimated gas flaring volumes indicate that global gas flaring has declined by 19% since 2005, led by gas flaring reductions in Russia and Nigeria, the two countries with the highest gas flaring levels. The flaring efficiency of both Russia and Nigeria improved from 2005 to 2008, suggesting that the reductions in gas flaring are likely the result of either improved utilization of the gas, reinjection, or direct venting of gas into the atmosphere, although the effect of uncertainties in the satellite data cannot be ruled out. It is anticipated that the capability to estimate gas flaring volumes based on satellite data will spur improved utilization of gas that

  11. Fifteen-year Assessment of a Permeable Reactive Barrier for Treatment of Chromate and Trichloroethylene in Groundwater

    Science.gov (United States)

    The fifteen-year performance of a granular iron, permeable reactive barrier (PRB; Elizabeth City, North Carolina) is reviewed with respect to contaminant treatment (hexavalent chromium and trichloroethylene) and hydraulic performance. Due to in-situ treatment of the chromium sou...

  12. Editorial Introduction: New Year Resolutions

    Directory of Open Access Journals (Sweden)

    Terry Reese

    2016-01-01

    Full Text Available While New Year’s day came and went with very little fanfare at my house (well, if you don’t count our Star Wars marathon, I think I’d be remiss if I didn’t take the time to mark the passing of the new year, with a look ahead to the future.  And I think it is fitting, then, […

  13. The Last Fifteen Years of Schistosomiasis in Venezuela: Features and Evolution

    Directory of Open Access Journals (Sweden)

    Belkisyolé Alarcón de Noya

    1999-03-01

    Full Text Available Control of schistosomiasis in Venezuela has been a topic of major interest and controversy among the metaxenic parasitosis. A small area of transmission of approximately 15,000 km2 was thought to be eradicated some years ago. However, some epidemiological characteristics of our transmission area have limited the success on the way toward eradication. Since 1945, when the Schistosomiasis Control Program started, the prevalence in the endemic area has decreased from 14% in 1943 to 1.4% in 1996. Until 1982, the surveillance of active cases was based on massive stool examination. Since then, the Schistosomiasis Research Group (SRG recommended the additional use of serologic tests in the Control Program and the selective or massive chemotherapy depending on serological and parasitological prevalence of each community. At present, the real prevalence is underestimated due to the fact that approximately 80% of the individuals eliminate less than 100 eggs/g of feces. Those persons could be responsible for the maintenance of the foci going on and therefore limiting the impact of the control measures. Efforts of the SRG are being oriented toward improvement of immunodiagnostic tests by using defined antigens (enzymes and chemically synthesized peptides, derived from relevant molecules of the parasite, either for antibodies or antigens search. On the other hand, introduction of snail competitors has been a biological weapon in the control of the intermediate host in certain areas. However, the recent reinfestation of water courses by Biomphalaria glabrata, the increased prevalence in some areas, together with important administrative changes at the Control Program of the Minister of Health, have arisen new questions and doubts, challenging the eradication strategy proposed during the last decade.

  14. The prevalence and incidence of glaucoma in Denmark in a fifteen year period

    DEFF Research Database (Denmark)

    Kolko, Miriam; Horwitz, Anna; Thygesen, John

    2015-01-01

    PURPOSE: The purpose of the present study was to describe the prevalence, incidence and geographic variation of glaucoma in Denmark in the period from 1996 to 2011. Moreover, the aim was to identify the treatment patterns of glaucoma within the studied period. METHODS: All Danish citizens were...... included throughout the study period. The National Prescription Registry was used to identify all claimed prescriptions for glaucoma medication. RESULTS: A total of 116,592 incident glaucoma patients were identified. Average age at onset was 66 years (range: 0-105 years), 55% were women. The prevalence...... of glaucoma increased from 0.79% to 1.72% during the investigated period. In 2011 glaucoma affected 3.76% of the population above 50 years and 10% in patients above 80 years. The age-specific incidence rate of glaucoma seemed to be constant and the increasing prevalence was primarily attributed to an aging...

  15. From infancy to adolescence: fifteen years of continuous treatment with hydroxyurea in sickle cell anemia.

    Science.gov (United States)

    Hankins, Jane S; Aygun, Banu; Nottage, Kerri; Thornburg, Courtney; Smeltzer, Matthew P; Ware, Russell E; Wang, Winfred C

    2014-12-01

    Despite documented laboratory and clinical benefits of hydroxyurea for children with sickle cell anemia (SCA), the drug's long-term safety and efficacy remains poorly defined. The HUSOFT trial and extension study examined feasibility, toxicity, and hematological efficacy of hydroxyurea in infants with SCA. This report describes HUSOFT participants who have continued hydroxyurea therapy for 15 years. With IRB approval, medical records were reviewed for clinical, laboratory, and growth parameters. Twenty-eight infants enrolled in the original 2-year HUSOFT study received open-label liquid hydroxyurea at 20 mg/kg/day; 17 completed the extension study with dose escalation to 30 mg/kg/day. Eight of these 17 (6 girls and 2 boys, all HbSS) have continued on daily hydroxyurea for at least 15 years (median age at last follow-up 17.6 years) without interruption. All hematologic indices (Hb concentration, mean corpuscular volume (MCV), fetal hemoglobin) showed sustained effect after 15 years. The median maximum tolerated dose of hydroxyurea has decreased from 30 to 26 mg/kg/day (range 19.5-31.2); neutropenia [absolute neutrophil count (ANC)hydroxyurea therapy since infancy appears safe and efficacious in SCA.

  16. Fifteen-Year Radiotherapy Outcomes of the Randomized PORTEC-1 Trial for Endometrial Carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Creutzberg, Carien L., E-mail: c.l.creutzberg@lumc.nl [Department of Clinical Oncology, Leiden University Medical Center (Netherlands); Nout, Remi A. [Department of Clinical Oncology, Leiden University Medical Center (Netherlands); Lybeert, Marnix L.M. [Department of Radiotherapy, Catharina Hospital Eindhoven (Netherlands); Warlam-Rodenhuis, Carla C. [Department of Radiation Oncology, University Medical Center Utrecht (Netherlands); Jobsen, Jan J. [Department of Radiotherapy, Medisch Spectrum Twente, Enschede (Netherlands); Mens, Jan-Willem M. [Department of Radiation Oncology, ErasmusMC-Daniel den Hoed Cancer Center, Rotterdam (Netherlands); Lutgens, Ludy C.H.W. [MAASTRO clinic, Maastricht (Netherlands); Pras, Elisabeth [Department of Radiotherapy, University Medical Center Groningen (Netherlands); Poll-Franse, Lonneke V. van de [Comprehensive Cancer Centre South, Eindhoven and Center of Research on Psychology in Somatic Diseases, Tilburg University (Netherlands); Putten, Wim L.J. van [Department of Biostatistics, ErasmusMC-Daniel den Hoed Cancer Center, Rotterdam (Netherlands)

    2011-11-15

    Purpose: To evaluate the very long-term results of the randomized Post Operative Radiation Therapy in Endometrial Carcinoma (PORTEC)-1 trial for patients with Stage I endometrial carcinoma (EC), focusing on the role of prognostic factors for treatment selection and the long-term risk of second cancers. Patients and Methods: The PORTEC trial (1990-1997) included 714 patients with Stage IC Grade 1-2 or Stage IB Grade 2-3 EC. After surgery, patients were randomly allocated to external-beam pelvic radiotherapy (EBRT) or no additional treatment (NAT). Analysis was by intention to treat. Results: 426 patients were alive at the date of analysis. The median follow-up time was 13.3 years. The 15-year actuarial locoregional recurrence (LRR) rates were 6% for EBRT vs. 15.5% for NAT (p < 0.0001). The 15-year overall survival was 52% vs. 60% (p = 0.14), and the failure-free survival was 50% vs. 54% (p = 0.94). For patients with high-intermediate risk criteria, the 15-year overall survival was 41% vs. 48% (p = 0.51), and the 15-year EC-related death was 14% vs. 13%. Most LRR in the NAT group were vaginal recurrences (11.0% of 15.5%). The 15-year rates of distant metastases were 9% vs. 7% (p = 0.25). Second primary cancers had been diagnosed over 15 years in 19% of all patients, 22% vs. 16% for EBRT vs. NAT (p = 0.10), with observed vs. expected ratios of 1.6 (EBRT) and 1.2 (NAT) compared with a matched population (p = NS). Multivariate analysis confirmed the prognostic significance of Grade 3 for LRR (hazard ratio [HR] 3.4, p = 0.0003) and for EC death (HR 7.3, p < 0.0001), of age >60 (HR 3.9, p = 0.002 for LRR and 2.7, p = 0.01 for EC death) and myometrial invasion >50% (HR 1.9, p = 0.03 and HR 1.9, p = 0.02). Conclusions: The 15-year outcomes of PORTEC-1 confirm the relevance of HIR criteria for treatment selection, and a trend for long-term risk of second cancers. EBRT should be avoided in patients with low- and intermediate-risk EC.

  17. Fifteen years of cold matter on the atom chip: promise, realizations, and prospects

    Science.gov (United States)

    Keil, Mark; Amit, Omer; Zhou, Shuyu; Groswasser, David; Japha, Yonathan; Folman, Ron

    2016-01-01

    Here we review the field of atom chips in the context of Bose–Einstein Condensates (BEC) as well as cold matter in general. Twenty years after the first realization of the BEC and 15 years after the realization of the atom chip, the latter has been found to enable extraordinary feats: from producing BECs at a rate of several per second, through the realization of matter-wave interferometry, and all the way to novel probing of surfaces and new forces. In addition, technological applications are also being intensively pursued. This review will describe these developments and more, including new ideas which have not yet been realized. PMID:27499585

  18. Fifteen years' experience of intestinal and multivisceral transplantation in the Nordic countries

    DEFF Research Database (Denmark)

    Varkey, Jonas; Simrén, Magnus; Jalanko, Hannu

    2015-01-01

    was the most common complication and occurred in 79% of the patients followed by post-transplantation lymphoproliferative disorders (21%) and graft-versus-host disease (18%). The 1- and 5-year survival was 79% and 65% respectively for the whole cohort and nutritional autonomy was achieved in 73% of the adults...... and 57% of the children at 1 year after transplantation. CONCLUSION: This collective Nordic experience confirms that intestinal transplantation is a complex procedure with many complications, yet with the possibility to provide long-term survival in selected conditions previously considered untreatable....

  19. Fifteen-year survival of anterior all-ceramic cantilever resin-bonded fixed dental prostheses.

    Science.gov (United States)

    Kern, Matthias

    2017-01-01

    The aim of this follow-up study was to report the long-term outcome of all-ceramic cantilever resin-bonded fixed dental prostheses (RBFDPs). In 16 patients (mean age of 33.3±17.5years) 22 RBFDPs made from a glass-infiltrated alumina ceramic (In-Ceram) were inserted with a phosphate monomer containing luting agent after air-abrasion of the retainer wings. The abutment preparation included a shallow groove on the cingulum and a small proximal box. The restorations replacing 16 maxillary and 6 mandibular incisors were followed over a mean observation time of 188.7 months. No restoration debonded. Two RBFDPs fractured and were lost 48 and 214 months after insertion, respectively. The 10-year and 15-year survival rates were both 95.4% and dropped to 81.8% after 18 years. Anterior all-ceramic cantilever RBFDPs exhibited an excellent clinical longevity. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. Fifteen Years of Research on Graduate Education in Economics: What Have We Learned?

    Science.gov (United States)

    Stock, Wendy A.; Siegfried, John J.

    2014-01-01

    In this article, the authors summarize their 15 years of research on graduate education in economics in the United States. They examine all stages of the process, from the undergraduate origins of eventual economics PhDs to their attrition and time-to-degree outcomes. For PhD completers, the authors examine job market outcomes, research…

  1. In Retrospect: A Fifteen-Year Follow-Up Report of Speech-Language-Disordered Children.

    Science.gov (United States)

    King, Rella R.; And Others

    1982-01-01

    A 15-year follow-up of 50 children initially diagnosed as communicatively impaired is reported. The survey describes Ss in terms of the educational levels they have attained, their motor skills, their social skills as perceived by their families, and any communication problems that may exist. (Author/DB)

  2. Fifteen-Year Growth of Six Planted Hardwood Species on Sharkey Clay Soil

    Science.gov (United States)

    Roger M. Krinard; Harvey E. Kennedy

    1987-01-01

    Six hardwood species planted on Sharkey clay soil that had been disked the first 5 years for weed control were significantly taller at age 5 when compared to species grown on mowed sites. By age 15, there were no differences in heights within species except for sweet pecan. Average heights by species at age 15 were: cottonwood (Populus deltoides...

  3. Fifteen years of the Family Eating and Activity Habits Questionnaire (FEAHQ): an update and review.

    Science.gov (United States)

    Golan, M

    2014-04-01

    The Family Eating and Activity Habits Questionnaire (FEAHQ) is a 32-item self-report instrument designed to assess the eating and activity habits of family members as well as obesogenic factors in the overall home environment (stimulus and behaviour patterns) related to weight. Originally, this questionnaire, which was developed in Israel, was designed for use in family-based weight-management interventions that emphasized changes in the environment, and in parents' knowledge, behaviours and modelling. It was developed for use with children aged 6-11 years and designed for co-completion by parents or caretakers and their children. Over the years, it has been administered in research and clinical settings in Israel, England, Australia and other countries. Its 15-year anniversary calls for an update in the literature regarding adjustments made to improve its use in different settings and with different ethnic populations and the psychometric properties of the revised version. The goal of this paper is threefold: (i) to describe the history and development of the FEAHQ; (ii) to present new data supporting the psychometric properties of the subscales of the Revised FEAHQ (FEAHQ-R) for ages 6-12 years and (iii) to review the clinical and research literature reporting on FEAHQ subscales. The psychometric properties of the revised questionnaire were evaluated in a randomized control trial and in a naturalistic, community-based study to promote healthy lifestyle among families with children 6-12 years of age from different ethnic populations. The tool demonstrated good test-retest reliability when completed by caretakers and very good internal consistency. The questionnaire scores discriminated between obese and normal-weight children and predicted the weight classification of 66% of the participants. The FEAHQ-R is a useful clinical tool for identifying target behaviors for treatment and monitoring treatment progress that centers on overweight prevention and weight

  4. The long-awaited EU-Mercosur Association Agreement after fifteen years of negotiation

    Directory of Open Access Journals (Sweden)

    Manuel Cienfuegos Mateo

    2018-02-01

    Full Text Available The EU and Mercosur have maintained intense political, economic and cooperation relations for 20 years. Nevertheless, they have still not managed to implement the interregional framework cooperation agreement signed in Madrid on December 15th 1995. This is due in large part to the profound differences on agricultural and industrial issues that have cropped up during the rounds of negotiation and technical meetings. As in 2004, this means that the establishment of a future EU-Mercosur Association Agreement including not only a “free trade agreement plus”, but also the pillars of cooperation and political dialogue, finds itself once again at a crossroads. However, as the main problems are well known, agreement is not impossible if both partners are able to exchange complete new commercial offers during the year 2016.

  5. The United Kingdom’s Naval Shipbuilding Industrial Base: The Next Fifteen Years

    Science.gov (United States)

    2005-01-01

    the United Kingdom 71 Lauder College are developing improved procedures for selecting and training craft modern apprentices, as well as programmes...Next 15 Years for the names of the suppliers, information on what they provided, and the amount of money spent on them. We also asked the ship- yards...analysis on all money spent on suppliers; (2) ration- alise the supply base, consolidating contracts where possible (and where this fits the legal

  6. Fifteen years experience with an in-vitro fertilization surrogate gestational pregnancy programme.

    Science.gov (United States)

    Goldfarb, J M; Austin, C; Peskin, B; Lisbona, H; Desai, N; de Mola, J R

    2000-05-01

    The purpose of our study was to review and evaluate retrospectively the experience of an in-vitro fertilization (IVF) surrogate gestational programme in a tertiary care and academic centre. In a 15 year period from 1984 to 1999, a total of 180 cycles of IVF surrogate gestational pregnancy was started in 112 couples. On average, the women were 34.4 +/- 4.4 years of age, had 11.1 +/- 0.72 oocytes obtained per retrieval, 7.1 +/- 0.5 oocytes fertilized and 5. 8 +/- 0.4 embryos subsequently cleaved. Sixteen cycles (8.9%) were cancelled due to poor stimulation. Except for six cycles (3.3%) where there were no embryos available, an average of 3.2 +/- 0.1 embryos was transferred to each individual recipient. The overall pregnancy rate per cycle after IVF surrogacy was 24% (38 of 158), with a clinical pregnancy rate of 19% (30 of 158), and a live birth rate of 15.8% (25 of 158). When compared to patients who underwent a hysterectomy, individuals with congenital absence of the uterus had significantly more oocytes retrieved (P surrogate gestation is an established, yet still controversial, approach to the care of infertile couples. Take-home baby rates are comparable to conventional IVF over the same 15 year span in our programme. Patients with congenital absence of the uterus responded to ovulation induction better than patients who underwent a hysterectomy, perhaps due in part to ovarian compromise from previous surgical procedures.

  7. Fifteen-year phenological plant species and meteorological trends in central Italy

    Science.gov (United States)

    Orlandi, F.; Ruga, L.; Bonofiglio, T.; Romano, B.; Fornaciari, M.

    2014-07-01

    The present study was carried out in a phenological garden in central Italy that contains vegetative clones of shrubs and trees common to several international phenological gardens, such as Cornus sanguinea L.; Corylus avellana L.; Ligustrum vulgare L.; Robinia pseudoacacia L.; Salix acutifolia Willd. and Sambucus nigra L. Vegetative plant growth monitoring was carried out weekly using common international keys: BBCH07, bud break and leaf unfolding; BBCH19, young unfolded leaf; BBCH91, adult leaves; BBCH93, beginning of leaf colouring. The phenological dates thus obtained provide a model of the development for these different species in relation to the 15-year period of observation (1997-2011). From a meteorological point of view, temperature and precipitation trends were studied, with the highest anomalies during the study period recorded during the first 2 months of the year (January, February). There was relative invariance in the manifestation of the open bud phase and the contemporary advance of the young open leaves phase, particularly from 2006. This was accompanied by shortening of the leaf opening period, which appeared due to more rapid spring temperature increases over the last few years. The advance tendency of the BBCH91 phase showed adult leaves from the first summer weeks with fully green foliage monitored for a long time. Generally, the autumn leaf colouring phase tended to remain constant, with the exception of Salix acutifolia and Sambucus nigra, for which, on the other hand, the first leaf development phases appeared to be most likely influenced by the photoperiod.

  8. Macrophytes of the Grlište reservoir (Serbia: Fifteen years after its establishment

    Directory of Open Access Journals (Sweden)

    Stanković Ž.

    2009-01-01

    Full Text Available A large number of macrophytes, often in dense populations, have developed on the Grlište Reservoir, Serbia over a period of 15 years. Fast development of vegetation is a consequence of anthropogenic impact in lake management. The methodology used in this research covered 100% of the water body, including all areas with or without aquatic plants. The results indicate that plant communities are still in the early phase of development. This leaves space for future development of competitor macrophyte species (Najas marina, Eleocharis palustris, Typha latifolia, Typha angustifolia, Phragmites australis, etc. capable of endangering stability of the lake, which will tend toward eutrophication.

  9. International Conference 'Fifteen Years after the Chornobyl Accident. Lessons Learned'. Abstracts Learning

    International Nuclear Information System (INIS)

    Anon

    2001-01-01

    The main aims of the conference are: for the scientific community in the most affected countries, to develop a common vision with the international scientific community with regard to the consequences of the Chornobyl disaster (in ecological, medical, social and other areas 15 years post-Chornobyl); to drawing conclusions and providing recommendations to allow decision makers at both national and international level to take further steps to mitigate the effects of the disaster. For the results of the Conference, to represent a common international understanding of the current situation resulting from the accident and the future initiatives which will be necessary to counter its effects

  10. Fifteen years of portfolio assessment of dental hygiene student competency: lessons learned.

    Science.gov (United States)

    Gadbury-Amyot, Cynthia C; Bray, Kimberly Krust; Austin, Kylie J

    2014-10-01

    Adoption of portfolio assessment in the educational environment is gaining attention as a means to incorporate self-assessment into the curriculum and to use evidence to support learning outcomes and to demonstrate competency. Portfolios provide a medium for students to demonstrate and document their personal and professional growth across the curriculum. The purpose of this literature review is to discuss the drivers for portfolio education, the benefits to both students and program faculty/administrators, the barriers associated with portfolio use, and suggested solutions that have been determined through several years of "lessons learned." The University of Missouri Kansas City School of Dentistry, Division of Dental Hygiene department has been utilizing portfolio assessment for over 15 years and has collected data related to portfolio performance since 2001. Results from correlational statistics calculated on the 312 dental hygiene students that graduated from 2001 to 2013 demonstrate a positive and significant relationship between portfolio performance and overall GPA as well as portfolio performance and NBDHE scores. Copyright © 2014 The American Dental Hygienists’ Association.

  11. Fifteen-Year-Old Male with Type 2 Autoimmune Pancreatitis: An Argument for Endoscopy

    Directory of Open Access Journals (Sweden)

    Nathan T. Kolasinski

    2017-05-01

    Full Text Available Type 2 autoimmune pancreatitis, an increasingly recognized etiology of pancreatitis in patients less than 20 years old, has characteristically been diagnosed with the histological finding of duct-centric pancreatitis in a patient who lacks elevated serum immunoglobulin G4. We present the case of a nonobese 15-year-old male, without any chronic medical conditions, who presented with the chief complaint of abdominal pain. The laboratory study results were remarkable for a lipase level of 5,419 U/L and a γ-glutamyl transferase level of 373 U/L. Magnetic resonance cholangiopancreatography revealed delayed contrast enhancement of the pancreas, diffuse parenchymal enlargement, and lack of normal lobulation. The patient’s serum immunoglobulin G4 level was found to be 66 mg/dL, which was within normal limits and supportive of a diagnosis of type 2 autoimmune pancreatitis. Despite the absence of intestinal complaints, the patient underwent subsequent endoscopy due to the correlation of type 2 autoimmune pancreatitis with inflammatory bowel disease that has been described in recent literature. Pan-colonic mild colitis was visualized, and the patient began treatment with steroids, to which he quickly responded. Performing endoscopy on this patient allowed for confident initiation of early therapy for both autoimmune pancreatitis and inflammatory bowel disease, and may have limited further surgical intervention and disease progression. For these reasons, this case highlights the utility of endoscopy in pediatric patients with suspected type 2 autoimmune pancreatitis, even in the absence of intestinal symptoms.

  12. Fifteen years of kidney biopsies in children: A single center in Egypt

    Directory of Open Access Journals (Sweden)

    Ashraf Bakr

    2014-01-01

    Full Text Available This study retrospectively investigates the indications and results of renal biopsy in children to determine the patterns of childhood kidney disease in a single tertiary children′s hospital in Egypt. We included all the patients who underwent ultrasound-guided renal biopsy from 1998 to 2012. All the kidney biopsies were studied under light microscopy, while immunofluorescence and electron microscopy were performed when indicated. A total of 1246 renal biopsies were performed over 15 years, on 1096 patients. The mean age of the patients at the time of biopsy was 9.2 ± 3.7 years. The main indication for a biopsy was the steroid-resistant nephrotic syndrome (n = 354, 28.4%, followed by the atypical nephrotic syndrome (n = 250, 20.1%, and renal abnormalities in the systemic diseases (n = 228, 18.3 %. In the 1226 pathologically diagnosed specimens, primary glomerulonephritis was the most common finding (n = 826, 67.4%, followed by secondary glomerulonephritis (n = 238, 19.4%. The most common causes of primary glomerulonephritis were Minimal Change Disease (MCD (n = 267, 21.8%, diffuse proliferative glomerulonephritis (n = 188, 15. 3%, and focal proliferative glomerulonephritis (n = 164, 13.3%. Lupus nephritis (n = 209, 17% was the most common cause of secondary glomerulonephritis. We conclude that the steroid-resistant nephrotic syndrome was the most frequent indication for biopsy and minimal change disease was the most common histopathological finding in our population.

  13. Fifteen years of imposex and tributyltin pollution monitoring along the Portuguese coast.

    Science.gov (United States)

    Laranjeiro, Filipe; Sánchez-Marín, Paula; Oliveira, Isabel Benta; Galante-Oliveira, Susana; Barroso, Carlos

    2018-01-01

    IMO's Anti-Fouling Systems convention banned the use of organotin-based antifouling systems in 2008 as the ultimate effort to stop tributyltin (TBT) inputs into the marine environment. One of the hazardous effects of TBT is imposex (the superimposition of male sexual characters onto gastropod females), a phenomenon that may cause female sterility and the gastropod populations decline. Despite previous European Union legislation had already been shown effective in reducing the imposex levels along the Portuguese coast, this study intends to confirm these decreasing trends after 2008 and describe the global evolution in the last 15 years. Imposex levels were assessed in two bioindicators - the dog-whelk Nucella lapillus and the netted-whelk Nassarius reticulatus (Gastropoda, Prosobranchia) - in 2011 and 2014, and the results were compared with previous years. Both species showed progressive decreasing trends in imposex levels over the last 15 years; median values of the vas deferens sequence index (VDSI) fell from 3.96 to 0.78 in N. lapillus and from 3.39 to 0.29 in N. reticulatus. The temporal/spatial evolution of imposex suggests an apparent shift of TBT hotspots, being now restricted to fishing ports and marinas in detriment of large commercial harbours where TBT levels fell rapidly. Butyltins were measured in the whole tissues of N. lapillus females collected in 2014: monobutyltin (MBT) varied from < DL (detection limit: 1 ng Sn/g) to 13 ng Sn/g dw, dibutyltin (DBT) from 2.2 to 27 ng Sn/g dw and TBT from 1.5 to 55 ng Sn/g dw. Although TBT body burden has declined over time, the butyltin degradation index ([MBT]+[DBT])/[TBT] exhibited values < 1 in c. a. 90% of the sites assessed, suggesting that recent TBT inputs are still widespread in the Portuguese coast eventually due to illegal use of TBT antifouling systems and TBT desorption from sediments. Copyright © 2017 Elsevier Ltd. All rights reserved.

  14. Fifteen Years of Operation at NASA's National Transonic Facility with the World's Largest Adjustable Speed Drive

    Science.gov (United States)

    Sydnor, George H.; Bhatia, Ram; Krattiger, Hansueli; Mylius, Justus; Schafer, D.

    2012-01-01

    In September 1995, a project was initiated to replace the existing drive line at NASA's most unique transonic wind tunnel, the National Transonic Facility (NTF), with a single 101 MW synchronous motor driven by a Load Commutated Inverter (LCI). This Adjustable Speed Drive (ASD) system also included a custom four-winding transformer, harmonic filter, exciter, switch gear, control system, and feeder cable. The complete system requirements and design details have previously been presented and published [1], as well as the commissioning and acceptance test results [2]. The NTF was returned to service in December 1997 with the new drive system powering the fan. Today, this installation still represents the world s largest horizontal single motor/drive combination. This paper describes some significant events that occurred with the drive system during the first 15 years of service. These noteworthy issues are analyzed and root causes presented. Improvements that have substantially increased the long term viability of the system are given.

  15. Fifteen years of international trade in wood and forest-related products

    International Nuclear Information System (INIS)

    Desclos, Pierre-Marie

    2014-01-01

    Little is generally known about international trade in forest-related products in spite of the fact that a significant portion of world production is exported. Two irreversible trends underlie international trade in forest-related products. One is globalization while the other is adding as much value as possible locally by processing the materials to the greatest extent possible in the country of origin. Some of the more surprising recent developments are the growth in trade in wood as a source of energy and the dependency of Europe on its massive imports in this area. International trade in forest-related products is a continually changing sector that follows developments in the technical, economic, social and political spheres. Its growth has been spectacular and will remain strong in coming years. The greatest potential for development will come from environmental management, improved logistics and innovation. (authors)

  16. Fifteen-year follow-up of smoking prevention effects in the North Karelia youth project.

    Science.gov (United States)

    Vartiainen, E; Paavola, M; McAlister, A; Puska, P

    1998-01-01

    This study evaluated the long-term effects of a school- and community-based smoking prevention program in Finland. Four intervention schools from North Karelia and two control schools from another province were chosen for the evaluation. Students who received the intervention were taught to resist social pressures to smoke. The program began in 1978 with seventh-grade students and ran through 1980, with a 15-year follow-up. In North Karelia, a community-based smoking cessation program for adults was also carried out. Mean lifetime cigarette consumption was 22% lower among program subjects than among control subjects. Smoking and prevalence were lower up to the age of 21. Long-term smoking prevention effects can be achieved if a school-based program using a social influence model is combined with community and mass media interventions.

  17. Buerger’s Disease in Tehran University of Medical Sciences Hospitals: A Fifteen Years Study

    Directory of Open Access Journals (Sweden)

    Salimi Javad

    2009-10-01

    Full Text Available Buerger's disease is an occlusive inflammatory disease of the small and medium-sized arteries and accounts for a variable proportion of patients with peripheral vascular disease throughout the world. The aim of this study was to review the records of Buerger's disease patients admitted to surgery wards of our university hospitals. 277 patients with Buerger's disease were surgically treated between 1987 and 2002, in affiliated hospitals of Tehran University of Medical Sciences, in Iran. Two hundred and seventy three (98.6% of the patients were male, aged 41.5 ± 11 years (mean ± SD; 99.6% of which were smokers with an average of 22.9 pack/years tobacco use. The major complaints included: ischemic ulcers in 203 (73.3%, CI 95%: 0.68-0.77 patients, rest pain in 201 (72.6%, CI 95%: 0.64-0.73, paresthesia in 143 (51.3%, CI 95%: 0.48- 0.58. Vascular bypass, sympathectomy and amputation were performed in 9.7% (CI 95%: 0.08-0.14 and 69.3% (CI 95%: 0.51-0.60 and 59.6% (CI 95%: 0.65-0.73 of the patients, respectively. Lumbar sympathectomy was carried out in 177 (63.9% patients, while 15 (5.4% patients underwent thoracic sympathectomy. In our study, afflicted patients were mostly young males, inveterate tobacco smokers. Patients presented frequently with ischemic ulcers or severe rest pain; thrombophlebitis and Raynaud's phenomenon were infrequent. Vascular reconstruction was rarely possible due to distal and segmental involvement; therefore sympathectomy and amputation were inevitable in a large group of patients in this study.

  18. Rheumatology Research Foundation Clinician Scholar Educator Award: Fifteen Years Promoting Rheumatology Educators and Education.

    Science.gov (United States)

    Berman, Jessica R; O'Rourke, Kenneth S; Kolasinski, Sharon L; Aizer, Juliet; Wheatley, Mary J; Battistone, Michael J; Siaton, Bernadette C; Criscione-Schreiber, Lisa; Pillinger, Michael H; Lazaro, Deana M

    2016-11-01

    The Rheumatology Research Foundation's Clinician Scholar Educator (CSE) award is a 3-year career development award supporting medical education research while providing opportunities for mentorship and collaboration. Our objective was to document the individual and institutional impact of the award since its inception, as well as its promise to strengthen the subspecialty of rheumatology. All 60 CSE Award recipients were surveyed periodically. Fifty-six of those 60 awardees (90%) responded to requests for survey information that included post-award activities, promotions, and further funding. Data were also collected from yearly written progress reports for each grant. Of the total CSE recipients to date, 48 of 60 (80%) are adult rheumatologists, 11 of 60 (18%) are pediatric rheumatologists, and 1 is an adult and pediatric rheumatologist. Two-thirds of survey respondents spend up to 30% of their total time in educational activities, and one-third spend greater than 30%. Thirty-one of the 60 CSE recipients (52%) have published a total of 86 medical education papers. Twenty-six of 52 (50%) had received an academic promotion following the award. Eleven awardees earned advanced degrees. We describe the creation and evolution of a grant program from a medical subspecialty society foundation and the impact on producing education research, individual identity formation, and ongoing support for educators. This community of rheumatology scholar educators now serves as an important resource at the national level for the American College of Rheumatology and its membership. We believe that this grant may serve as a model for other medical societies that want to promote education scholarship and leadership within their specialties. © 2016, American College of Rheumatology.

  19. Fifteen years after parental divorce: mental health and experienced life-events.

    Science.gov (United States)

    Angarne-Lindberg, Teresia; Wadsby, Marie

    2009-01-01

    The children who experienced their parents' divorce when the divorce rate in Sweden had begun to grow to higher levels than in preceding decades are today adults. The aim of this study was to investigate if adults who had experienced parental divorce 15 years before the time of our study, differed in mental health from those with continuously married parents, taking into account life events other than the divorce. Instruments used were the Symptom Checklist (SCL-90) measuring mental health and the Life Event questionnaire capturing the number and experience of occurred events. Forty-eight persons, who were 7-18 years old when their parents divorced, constituted the divorce group, and 48 persons matched on age, sex and growth environment formed the study groups. The SCL-90 showed a limited difference between the groups, but not concerning total mental health. A main finding was a difference with regard to sex and age; women aged 22-27 in the divorce group displayed poorer mental health than other participants in both groups. The results from the Life Event questionnaire showed that the divorce group had experienced a significantly larger number of events, and more life events were described as negative with difficult adjustment. A regression analysis showed a significant relation between the SCL-90, Global Severity Index and life events experienced as negative with difficult adjustment, divorce events excluded, but not with the divorce itself. It seems highly desirable to pay more attention than has thus far been paid to girls with experience of childhood divorce at age 7-12.

  20. From political controversy to a technical problem? Fifteen years of opioid substitution treatment in Finland.

    Science.gov (United States)

    Selin, Jani; Hakkarainen, Pekka; Partanen, Airi; Tammi, Tuukka; Tigerstedt, Christoffer

    2013-11-01

    The aim of the article is to analyze changes in opioid substitution treatments (OST) in Finland. OST spread in Finland in the late 1990s and early 2000s (Phase 1). Since then, OST has become an integrated part of Finnish drug policy and is provided in various substance abuse treatment units as well as in municipal health centers (Phase 2). The paper analyses the policy around the implementation of opioid substitution treatment in Finland, focusing on identifying the key factors and the relations between them that have contributed to the implementation of OST in Finland. OST has become accepted in Finland during the past ten years as a crucial element of a harm reduction strategy. Present incentives behind this development are not as clearly related to drug-specific policies as in the late 1990s; rather, they stem from both the restructuring of health care services (e.g. cost-effectiveness) and the strengthening of the medical or technico-administrative approach to the development of OST. Since the early 2000s, the development of substitution treatment in Finland has not taken place under explicit drug-political guidance, but largely as a result of many differing intended and unintended effects. One of the unintended effects is the fact that buprenorphine has replaced heroin as the most commonly misused opioid in Finland. Copyright © 2013 Elsevier B.V. All rights reserved.

  1. Fifteen years of microbiological investigation in Opalinus Clay at the Mont Terri rock laboratory (Switzerland)

    Energy Technology Data Exchange (ETDEWEB)

    Leupin, O.X. [National Cooperative for the Disposal of Radioactive Waste (NAGRA), Wettingen (Switzerland); Bernier-Latmani, R.; Bagnoud, A. [Swiss Federal Office of Technology EPFL, Lausanne (Switzerland); Moors, H.; Leys, N.; Wouters, K. [Belgian Nuclear Research Centre SCK-CEN, Mol (Belgium); Stroes-Gascoyne, S. [University of Saskatchewan, Saskatoon (Canada)

    2017-04-15

    Microbiological studies related to the geological disposal of radioactive waste have been conducted at the Mont Terri rock laboratory in Opalinus Clay, a potential host rock for a deep geologic repository, since 2002. The metabolic potential of microorganisms and their response to excavation-induced effects have been investigated in undisturbed and disturbed claystone cores and in pore- (borehole) water. Results from nearly 15 years of research at the Mont Terri rock laboratory have shown that microorganisms can potentially affect the environment of a repository by influencing redox conditions, metal corrosion and gas production and consumption under favourable conditions. However, the activity of microorganisms in undisturbed Opalinus Clay is limited by the very low porosity, the low water activity, and the largely recalcitrant nature of organic matter in the claystone formation. The presence of microorganisms in numerous experiments at the Mont Terri rock laboratory has suggested that excavation activities and perturbation of the host rock combined with additional contamination during the installation of experiments in boreholes create favourable conditions for microbial activity by providing increased space, water and substrates. Thus effects resulting from microbial activity might be expected in the proximity of a geological repository i.e., in the excavation damaged zone, the engineered barriers, and first containments (the containers). (authors)

  2. Measured and modelled trends in European mountain lakes: results of fifteen years of cooperative studies

    Directory of Open Access Journals (Sweden)

    Michela ROGORA

    2004-02-01

    Full Text Available Papers included in this Special Issue of the Journal of Limnology present results of long-term ecological research on mountain lakes throughout Europe. Most of these studies were performed over the last 15 years in the framework of some EU-funded projects, namely AL:PE 1 and 2, MOLAR and EMERGE. These projects together considered a high number of remote lakes in different areas or lake districts in Europe. Central to the projects was the idea that mountain lakes, while subject to the same chemical and biological processes controlling lowland lakes, are more sensitive to any input from their surroundings and can be used as earlywarning indicators of atmospheric pollution and climate change. A first section of this special issue deal with the results of long-term monitoring programmes at selected key-sites. A second section focuse on site-specific and regional applications of an acidification model designed to reconstruct and predict long-term changes in the chemistry of mountain lakes.

  3. Fifteen years of microbiological investigation in Opalinus Clay at the Mont Terri rock laboratory (Switzerland)

    International Nuclear Information System (INIS)

    Leupin, O.X.; Bernier-Latmani, R.; Bagnoud, A.; Moors, H.; Leys, N.; Wouters, K.; Stroes-Gascoyne, S.

    2017-01-01

    Microbiological studies related to the geological disposal of radioactive waste have been conducted at the Mont Terri rock laboratory in Opalinus Clay, a potential host rock for a deep geologic repository, since 2002. The metabolic potential of microorganisms and their response to excavation-induced effects have been investigated in undisturbed and disturbed claystone cores and in pore- (borehole) water. Results from nearly 15 years of research at the Mont Terri rock laboratory have shown that microorganisms can potentially affect the environment of a repository by influencing redox conditions, metal corrosion and gas production and consumption under favourable conditions. However, the activity of microorganisms in undisturbed Opalinus Clay is limited by the very low porosity, the low water activity, and the largely recalcitrant nature of organic matter in the claystone formation. The presence of microorganisms in numerous experiments at the Mont Terri rock laboratory has suggested that excavation activities and perturbation of the host rock combined with additional contamination during the installation of experiments in boreholes create favourable conditions for microbial activity by providing increased space, water and substrates. Thus effects resulting from microbial activity might be expected in the proximity of a geological repository i.e., in the excavation damaged zone, the engineered barriers, and first containments (the containers). (authors)

  4. Is Email Business Dying?: A Study on Evolution of Email Spam Over Fifteen Years

    Directory of Open Access Journals (Sweden)

    De Wang

    2014-05-01

    Full Text Available With the increasing dedication and sophistication of spammers, email spam is a persistent problem even today. Popular social network sites such as Facebook, Twitter, and Google+ are not exempt from email spam as they all interface with email systems. While some report predicts that email spam business is dying due to the decreasing volume of email spam. Whether email spam business is really dying is an interesting question. In this paper, we analyze email spam trends on Spam Archive dataset, which contains 5.5 million spam emails over 15 years (1998 – 2013. We statistically analyze emails contents including header information (e.g. content type and embedded items (e.g. URL links. Also, we investigate topic drift using topic modeling technique. Moreover, we perform network analysis on sender-to-receiver IP routing networks. Our study shows the dynamic nature of email spam over one and a half decades and demonstrate that the email spam business is not dying but more capricious.

  5. Fifteen-year patterns of soil carbon and nitrogen following biomass harvesting

    Science.gov (United States)

    Kurth, Valerie J.; D'Amato, Anthony W.; Palik, Brian J.; Bradford, John B.

    2014-01-01

    The substitution of forest-derived woody biofuels for fossil fuel energy has garnered increasing attention in recent years, but information regarding the mid- and long-term effects on soil productivity is limited. We investigated 15-yr temporal trends in forest floor and mineral soil (0–30 cm) C and N pools in response to organic matter removal treatments (OMR; stem-only harvest, SOH; whole-tree harvest, WTH; and whole-tree plus forest floor removal, FFR) at three edaphically distinct aspen (Populus tremuloides Michx. and P. grandidentata Michx.) forests in the Great Lakes region. The OMR and temporal effects were generally site specific, and both were most evident in the forest floor and combined profile (mineral soil and forest floor) compared with the mineral soil alone. Forest floor and combined profile C and N pools were generally similar in the SOH and WTH treatments, suggesting that slash retention has little impact on soil C and N in this time frame. Temporal changes in C and N at one of the three sites were consistent with patterns documented following exotic earthworm invasion, but mineral soil pools at the other two sites were stable over time. Power analyses demonstrated that significant effects were more likely to be detected for temporal differences than the effects of OMR and in the combined profile than in the mineral soil. Our findings are consistent with previous work demonstrating that OMR effects on soil C and N pools are site specific and more apparent in the forest floor than the mineral soil.

  6. Vegan-vegetarian low-protein supplemented diets in pregnant CKD patients: fifteen years of experience.

    Science.gov (United States)

    Attini, Rossella; Leone, Filomena; Parisi, Silvia; Fassio, Federica; Capizzi, Irene; Loi, Valentina; Colla, Loredana; Rossetti, Maura; Gerbino, Martina; Maxia, Stefania; Alemanno, Maria Grazia; Minelli, Fosca; Piccoli, Ettore; Versino, Elisabetta; Biolcati, Marilisa; Avagnina, Paolo; Pani, Antonello; Cabiddu, Gianfranca; Todros, Tullia; Piccoli, Giorgina B

    2016-09-20

    Pregnancy in women with advanced CKD becoming increasingly common. However, experience with low-protein diets in CKD patients in pregnancy is still limited. Aim of this study is to review the results obtained over the last 15 years with moderately restricted low-protein diets in pregnant CKD women (combining: CKD stages 3-5, proteinuria: nephrotic at any time, or > =1 g/24 at start or referral; nephrotic in previous pregnancy). CKD patients on unrestricted diets were employed for comparison. January, 2000 to September, 2015: 36 on-diet pregnancies (31 singleton deliveries, 3 twin deliveries, 1 pregnancy termination, 1 miscarriage); 47 controls (42 singleton deliveries, 5 miscarriages). The diet is basically vegan; since occasional milk and yoghurt are allowed, we defined it vegan-vegetarian; protein intake (0.6-0.8 g/Kg/day), keto-acid supplementation, protein-unrestricted meals (1-3/week) are prescribed according to CKD stage and nutritional status. Statistical analysis was performed as implemented on SPSS. Patients and controls were similar (p: ns) at baseline with regard to age (33 vs 33.5), referral week (7 vs 9), kidney function (CKD 3-5: 48.4 % vs 64.3 %); prevalence of hypertension (51.6 % vs 40.5 %) and proteinuria >3 g/24 h (16.1 % vs 12.2 %). There were more diabetic nephropathies in on-diet patients (on diet: 31.0 % vs controls 5.3 %; p 0.007 (Fisher)) while lupus nephropathies were non-significantly higher in controls (on diet: 10.3 % vs controls 23.7 %; p 0.28 (Fisher)). The incidence of preterm delivery was similar (vegan-vegetarian supplemented diet is confirmed as a safe option in the management of pregnant CKD patients.

  7. Fifteen years of HIV Protease Inhibitors: raising the barrier to resistance.

    Science.gov (United States)

    Wensing, Annemarie M J; van Maarseveen, Noortje M; Nijhuis, Monique

    2010-01-01

    HIV protease plays a crucial role in the viral life cycle and is essential for the generation of mature infectious virus particles. Detailed knowledge of the structure of HIV protease and its substrate has led to the design of specific HIV protease inhibitors. Unfortunately, resistance to all protease inhibitors (PIs) has been observed and the genetic basis of resistance has been well documented over the past 15 years. The arrival of the early PIs was a pivotal moment in the development of antiretroviral therapy. They made possible the dual class triple combination therapy that became known as HAART. However, the clinical utility of the first generation of PIs was limited by low bioavailability and high pill burdens, which ultimately reduced adherence and limited long-term viral inhibition. When therapy failure occurred multiple protease resistance mutations were observed, often resulting in broad class resistance. To combat PI-resistance development, second-generation approaches have been developed. The first advance was to increase the level of existing PIs in the plasma by boosting with ritonavir. The second was to develop novel PIs with high potency against the known PI-resistant HIV protease variants. Both approaches increased the number of protease mutations required for clinical resistance, thereby raising the genetic barrier. This review provides an overview of the history of protease inhibitor therapy, its current status and future perspectives. It forms part of a special issue of Antiviral Research marking the 25th anniversary of antiretroviral drug discovery and development, vol. 85, issue 1, 2010. Copyright 2009 Elsevier B.V. All rights reserved.

  8. The Burden of Leprosy in Cameroon: Fifteen Years into the Post-elimination Era.

    Science.gov (United States)

    Tabah, Earnest Njih; Nsagha, Dickson Shey; Bissek, Anne-Cecile Zoung-Kanyi; Bratschi, Martin W; Njamnshi, Theophilus Ngeh; Plushke, Gerd; Njamnshi, Alfred Kongnyu

    2016-10-01

    Cameroon achieved the elimination target of leprosy in 2000, and has maintained this status ever since. However, a number of health districts in the country continue to report significant numbers of leprosy cases. The aim of this study was to assess the burden of leprosy in Cameroon from 2000 to 2014. We obtained and analysed using the new leprosy burden concept of analysis, leprosy surveillance data collected between 2000 and 2014 from the National Leprosy Control Programme. Cameroon achieved leprosy elimination in 2000, registering a prevalence rate of 0.94/10,000 population. The prevalence rate dropped further to reach 0.20/10,000 population (78% reduction) in 2014. Similarly, the new case detection rate dropped from 4.88/100,000 population in 2000 to 1.46/100,000 population (85.3% reduction) in 2014. All 10 regions of the country achieved leprosy elimination between 2000 and 2014; however, 10 health districts were still to do so by 2014. The number of high-leprosy-burden regions decreased from 8 in 2000 to 1 in 2014. Seven and two regions were respectively medium and low-burdened at the end of 2014. At the health districts level, 18 remained at the high-leprosy-burdened level in 2014. The leprosy prevalence and detection rates as well as the overall leprosy burden in Cameroon have dropped significantly between 2000 and 2014. However, a good number of health districts remain high-leprosy-burdened. The National Leprosy Control Programme should focus efforts on these health districts in the next coming years in order to further reduce the burden of leprosy in the country.

  9. Using Event-history Analysis: Lessons from Fifteen Years of Practice

    Directory of Open Access Journals (Sweden)

    Le Bourdais, Céline

    2001-01-01

    Full Text Available EnglishInnovative statistical methods and new longitudinal surveys paved the way forthe widespread use of event-history analysis in social science during the last two decades. This paperdoes not attempt to provide a comprehensive review of these innovative methods. More modestly, it aimsat identifying and describing the problems encountered by two privileged users. Two types of problemsare discussed here. The first arises from the design of the surveys, or the way data are collected,and the difficulty in testing specific hypotheses with the existing databases. This is the kind ofproblem that Le Bordais has faced in analyzing family dynamics. The second has to do with thelimitations of the survival regression models when the longitudinal phenomena studied can no longerproperly be thought of as a small number of unique events. This is the type of problem enountered byRenaud in his ten-year Quebec panel sturvey of new immigrants.FrenchLes avancées récentes de la statistique et le développement de nouvellesenquêtes longitudinales ont suscité un engouement pour l’analyse des transitionsen sciences sociales au cours des deux dernières décennies. Cet article necherche pas à présenter une revue exhaustive des progrès qui ont été réalisésgrâce à l’utilisation de cette méthode d’analyse statistique. Plus modestement, iltente d’identifier et de décrire les problèmes rencontrés par deux chercheurs lorsde l’application de l’analyse des transitions. Deux types de problèmes sontdiscutés ici. Le premier est lié à la structure des enquêtes, soit à la nature mêmedes données recueillies, et à la difficulté de tester certaines hypothèses à partirdes bases de données existantes; c’est le type de problème rencontré par LeBourdais dans ses travaux sur la dynamique familiale. Le second tient auxlimites des modèles de l’analyse des transitions quand les phénomènes étudiésne peuvent plus être conceptualisés comme

  10. Chernobyl, fifteen years after

    International Nuclear Information System (INIS)

    2001-04-01

    This work has been constituted around four questions: the future of the Chernobyl site, the damaged reactor, and the sarcophagus around it; the health consequences of the accident on the persons that have worked on the damaged reactor and on the population in the countries the most exposed to fallout,; the situation of contaminated territories around the power plant and their management today; the last question concerns especially the France with the consequences of the radioactive cloud and what we know about the health risks induced by this event. (N.C.)

  11. Chernobyl: fifteen years later

    International Nuclear Information System (INIS)

    Gonzalez, Abel J.; )

    2001-01-01

    On Saturday 26 April 1986, an accident which was to have global repercussions occurred at Unit 4 of the Chernobyl nuclear power plant in Ukraine. The accident involved the largest short term release from a single source of radioactive materials to the atmosphere ever recorded. The debate about the consequences of the accident of Chernobyl became a real saga, probably one of the most extensive controversial history of the modern technological era. There was a general concern among the population regarding the health consequences of such releases and the safety of nuclear facilities. (author)

  12. Ancient earthquakes in the Roman city of Baelo Claudia (Cadiz, South of Spain): Fifteen years of archaeosimology research

    Energy Technology Data Exchange (ETDEWEB)

    Silva, P.G.; Giner-Robles, J.L.; Reicherter, K.; Rodriguez-Pascua, J.L.; Gruetzner, C.; Garcia-Jimenez, I.; Carrasco Garcia, P.; Bardaji, T.; Santos, G.; Roquero, E.; Roez, J.; Perucha, M.A.; Perez-Lopez, R.; Fernandez Macarro, B.; Martinez-Grana, A.; Goy, J.L.; Zazo, C.

    2016-07-01

    This work illustrates the state of the art on archaeoseismology of the ancient Roman city of Baelo Claudia (Tarifa, Cádiz) after nearly fifteen years of research. This ancient Roman site was affected by two earthquakes in the years AD 40–60 and AD 260–290 which promoted important urban and architectural changes and eventually the destruction and further abandonment of the city in AD 365–390. Earthquake Archaeoseismological Effects (EAEs) are catalogued, described and mapped in the entire monumental sector of the city mainly witnessing the last earthquake which occurred in AD 260–290. Mapping of oriented EAEs illustrate damage distribution all over the lower sector of the city, as well as the occurrence of suspect coseismic landslide and tsunami events. The structural analysis of oriented EAEs throughout the entire mapped sector suggests that the intervening ground motion was preferentially oriented in a SW to NE direction. The geoarchaeological analysis and some relevant archaeological anomalies, strongly suggest the occurrence of coeval tsunami events during both ancient earthquakes, pointing to the occurrence of an offshore seismic source SSW of the city. Several N-S normal faults have been identified around the Bolonia Bay area and some of them continue offshore SSW of Baelo Claudia. These faults with clear Quaternary activity can be considered as the more probable seismic sources for the events affecting the ancient Roman site and they are consistent with the mapped damage orientation displayed by the structural analysis of EAEs within the old Roman city. (Author)

  13. The First Fifteen Years of Steroid Receptor Research in Zebrafish; Characterization and Functional Analysis of the Receptors

    Directory of Open Access Journals (Sweden)

    Marcel J. M. Schaaf

    2017-07-01

    Full Text Available Steroid hormones regulate a wide range of processes in our body, and their effects are mediated by steroid receptors. In addition to their physiological role, these receptors mediate the effects of endocrine disrupting chemicals (EDCs and are widely used targets for dugs involved in the treatment of numerous diseases, ranging from cancer to inflammatory disorders. Over the last fifteen years, the zebrafish has increasingly been used as an animal model in steroid receptor research. Orthologues of all human steroid receptor genes appear to be present in zebrafish. All zebrafish steroid receptors have been characterized in detail, and their expression patterns have been analyzed. Functional studies have been performed using morpholino knockdown of receptor expression and zebrafish lines carrying mutations in one of their steroid receptor genes. To investigate the activity of the receptors in vivo, specific zebrafish reporter lines have been developed, and transcriptomic studies have been carried out to identify biomarkers for steroid receptor action. In this review, an overview of research on steroid receptors in zebrafish is presented, and it is concluded that further exploitation of the possibilities of the zebrafish model system will contribute significantly to the advancement of steroid receptor research in the next decade.

  14. Development and use of a fifteen year-old equivalent mathematical phantom for internal dose calculations. [Radiation dose distributions from /sup 99m/Tc-labeled compounds

    Energy Technology Data Exchange (ETDEWEB)

    Jones, R.M.; Poston, J.W.; Hwang, J.L.; Jones, T.D.; Warner, G.G.

    1976-06-01

    The existence of a phantom based on anatomical data for the average fifteen-year-old provides for a proficient means of obtaining estimates of absorbed dose for children of that age. Dimensions representative of an average fifteen-year-old human, obtained from various biological and medical research, were transformed into a mathematical construct of idealized shapes of the exterior, skeletal system, and internal organs of a human. The idealization for an average adult presently in use by the International Commission on Radiological Protection was used as a basis for design. The mathematical equations describing the phantom were developed to be readily adaptable to present-day methods of dose estimation. Typical exposure situations in nuclear medicine have previously been modeled for existing phantoms. With no further development of the exposure model necessary, adaptation to the fifteen-year-old phantom demonstrated the utility of the design. Estimates of absorbed dose were obtained for the administration of two radiopharmaceuticals, /sup 99m/Tc-sulfur colloid and /sup 99m/Tc-DMSA. (auth)

  15. One the way to European Union: changes in the Czech education system during the last fifteen years

    Directory of Open Access Journals (Sweden)

    Milada Rubusicová

    2004-01-01

    Full Text Available The aim of the present paper is to describe the changes in the educationalsystem in the Czech Republic that have taken place from the beginning of the 1990’s up to the present. The first part includes a brief characterisation of the initial situation typical of the socialist model of education and a specification ofthose areas that were viewed sceptically or critically after the „velvet revolution»in 1989, and that have been identified as areas where a change is desirable. Next part of the paper describes the course of changes and reforms of education in subsequent years. Periodisation of reforms is carried out on the basisof a general model that has been created, as one of possible approaches, for postsocialist countries in transformation. Each part of the model, i.e. the correctivereforms, modernization reforms, structural reforms and system reforms, containsan outline of the respective individual changes that took place in the Czech Republic in the course of the last, almost fifteen years, and the changes arecritically evaluated.There are some documents (e.g. the Czech «White Paper» that are of essential importance to the recent and current situation in the Czech educational systembecause they create basic visions and orientation but also a strategy of future changes. The documents are treated in the next section of the present text. It isfollowed by a brief analysis of the current situation of the Czech educational system, namely as regards the educational opportunities and participation in education, structure and network of schools, financing of the Czech educational system, and finally the school leavers’ prospects at the labour market.The last part of the paper deals with the outlooks of further development of the Czech educational system in connection with the entry into the European Union,and a conclusion is drawn that it involves mutual convergence of problems caused by global economic and social forces that also leads to

  16. Fifteen-Year Biochemical Relapse-Free Survival, Cause-Specific Survival, and Overall Survival Following I125 Prostate Brachytherapy in Clinically Localized Prostate Cancer: Seattle Experience

    International Nuclear Information System (INIS)

    Sylvester, John E.; Grimm, Peter D.; Wong, Jason; Galbreath, Robert W.; Merrick, Gregory; Blasko, John C.

    2011-01-01

    Purpose: To report 15-year biochemical relapse-free survival (BRFS), cause-specific survival (CSS), and overall survival (OS) outcomes of patients treated with I 125 brachytherapy monotherapy for clinically localized prostate cancer early in the Seattle experience. Methods and Materials: Two hundred fifteen patients with clinically localized prostate cancer were consecutively treated from 1988 to 1992 with I 125 monotherapy. They were prospectively followed as a tight cohort. They were evaluated for BRFS, CSS, and OS. Multivariate analysis was used to evaluate outcomes by pretreatment clinical prognostic factors. BRFS was analyzed by the Phoenix (nadir + 2 ng/mL) definition. CSS and OS were evaluated by chart review, death certificates, and referring physician follow-up notes. Gleason scoring was performed by general pathologists at a community hospital in Seattle. Time to biochemical failure (BF) was calculated and compared by Kaplan-Meier plots. Results: Fifteen-year BRFS for the entire cohort was 80.4%. BRFS by D'Amico risk group classification cohort analysis was 85.9%, 79.9%, and 62.2% for low, intermediate, and high-risk patients, respectively. Follow-up ranged from 3.6 to 18.4 years; median follow-up was 15.4 years for biochemically free of disease patients. Overall median follow-up was 11.7 years. The median time to BF in those who failed was 5.1 years. CSS was 84%. OS was 37.1%. Average age at time of treatment was 70 years. There was no significant difference in BRFS between low and intermediate risk groups. Conclusion: I 125 monotherapy results in excellent 15-year BRFS and CSS, especially when taking into account the era of treatment effect.

  17. Fifteen-Year Prospective Analysis of Television Viewing and Adiposity in African American and Caucasian Men and Women

    Directory of Open Access Journals (Sweden)

    Chung-Yu Chen

    2015-08-01

    Full Text Available There are limited data from long-term prospective studies on the association between television (TV viewing and obesity. We investigated this association between TV viewing and body mass index (BMI and waist circumference (WST over 15 years on 3,269 participants from the Coronary Artery Risk Development in Young Adults (CARDIA study. We used cross-lagged panel models at exam Years 5, 10, 15, and 20 over 15 years to assess the association between TV viewing and obesity. The cross-lagged effects of TV viewing on anthropometry were significant from exam Year 5 to Year 10 (B = 0.034 for BMI and 0.036 for WST. However, the cross-lagged effects of TV viewing at Years 10 and 15 on obesity at Years 15 and 20, respectively, were nonsignificant. The findings indicate that higher levels of TV viewing predicted higher BMI and WC in young adulthood, but this association was not observed as individuals aged over the following decade.

  18. How difficult is it to reintroduce a dragonfly? Fifteen years monitoring Leucorrhinia dubia at the receiving site

    Czech Academy of Sciences Publication Activity Database

    Dolný, A.; Šigutová, H.; Ožana, S.; Choleva, Lukáš

    2018-01-01

    Roč. 218, č. 3 (2018), s. 110-117 ISSN 0006-3207 Institutional support: RVO:67985904 Keywords : conservation translocation * dragonfly reintroduction * odonata Subject RIV: EH - Ecology, Behaviour OBOR OECD: Ecology Impact factor: 4.022, year: 2016

  19. Increasing penicillin resistance in pneumococci isolated from cerebrospinal fluid samples: Fifteen-year experience from a teaching hospital

    OpenAIRE

    Pehlivanoglu, Filiz; Sengoz, Gonul; Şengöz, Gönül; Gursoy, Sevtap

    2015-01-01

    Objective: There have been prominent changes in evaluation of resistance patterns of pneumococci and breakpoint values in recent years. We aimed to investigate the penicillin sensitivity of pneumococcal strains isolated from the ce­rebrospinal fluid specimens between the years 1997-2011 in our hospital and determine the MIC values under the light of these changes. Methods: Identification of pneumococci was made with conventional methods in patients with meningitis. MIC values for penicilli...

  20. Increasing penicillin resistance in pneumococci isolated from cerebrospinal fluid samples: Fifteen-year experience from a teaching hospital

    Directory of Open Access Journals (Sweden)

    Filiz Pehlivanoğlu

    2014-12-01

    Full Text Available Objective: There have been prominent changes in evaluation of resistance patterns of pneumococci and breakpoint values in recent years. We aimed to investigate the penicillin sensitivity of pneumococcal strains isolated from the ce­rebrospinal fluid specimens between the years 1997-2011 in our hospital and determine the MIC values under the light of these changes. Methods: Identification of pneumococci was made with conventional methods in patients with meningitis. MIC values for penicillin G were investigated by E test method in all strains. MIC values of pneumococci strains were evaluated ac­cording to values determined by CLSI for meningitis isolates in 2008. Results: A total of 57 strains were investigated in this study. The MIC range for penicillin was 0.016 - 0.75 μg/ml in S. pneumoniae strains. Seventy five percent of the strains were sensitive and eight strains (14% had resistance. MIC50 value was sensitive, and a MIC90 value was resistant. The first resistant strain was detected in 2000, and three strains were resistant in the last year. When examined over the years increased resistance was 5.3% in the first five-year period seems to be 28.6% in the last five-year period. Conclusions: Knowledge on penicillin resistance patterns and surveillance is very important in the empirical treatment in pneumococcal meningitis. J Microbiol Infect Dis 2014; 4(4: 136-140

  1. Chinese and world equity markets : A review of the volatilities and correlations in the first fifteen years

    NARCIS (Netherlands)

    Lin, Kuan Pin; Menkveld, Albert J.; Yang, Zhishu

    2009-01-01

    After more than 15 years of Chinese equity markets, we study how variance, covariance, and correlations have developed in these markets relative to world markets, based on the dynamic conditional correlation (DCC) model of Engle [Engle, R., 2002. A dynamic conditional correlation: A simple class of

  2. An Atypical Eating Disorder with Crohn's Disease in a Fifteen-Year-Old Male: A Case Study.

    Science.gov (United States)

    Holaday, Margot; And Others

    1994-01-01

    Discusses how 6 months after psychological intervention for an eating disorder, a 15-year-old male was diagnosed with Crohn's disease, a chronic inflammatory bowel disease. Addresses need for additional training for those from traditional school and counseling psychology programs. Advocates a team approach and consultations. (RJM)

  3. Time-series photometric spot modeling. 2: Fifteen years of photometry of the bright RS CVn binary HR 7275

    Science.gov (United States)

    Strassmeier, K. G.; Hall, D. S.; Henry, G. W.

    1994-01-01

    We present a time-dependent spot modeling analysis of 15 consecutive years of V-band photometry of the long-period (P(sub orb) = 28.6 days) RS CVn binary HR 7275. This baseline in time is one of the longest, uninterrupted intervals a spotted star has been observed. The spot modeling analysis yields a total of 20 different spots throughout the time span of our observations. The distribution of the observed spot migration rates is consistent with solar-type differential rotation and suggests a lower limit of the differential-rotation coefficient of 0.022 +/-0.004. The observed, maximum lifetime of a single spot (or spot group) is 4.5 years, the minimum lifetime is approximately one year, but an average spot lives for 2.2 years. If we assume that the mechanical shear by differential rotation sets the upper limit to the spot lifetime, the observed maximum lifetime in turn sets an upper limit to the differential-rotation coefficient, namely 0.04 +/- 0.01. This would be differential rotation just 5 to 8 times less than the solar value and one of the strongest among active binaries. We found no conclusive evidence for the existence of a periodic phenomenon that could be attributed to a stellar magnetic cycle.

  4. Fifteen-year Clinical Follow-up of Restoration of Extensive Cervical Resorption in a Maxillary Central Incisor.

    Science.gov (United States)

    Reston, E G; Bueno, Rpr; Closs, L Q; Zettermann, J

    Internal bleaching in endodontically treated teeth requires care and protection to prevent harm to the periodontal ligament due to peroxide and may result in external root resorption. There is a myriad of treatment options when this occurs, such as monitoring, extraction, and subsequent rehabilitation with implants or fixed prosthodontics. In some cases, such as the one described here, a conservative attempt to maintain the tooth as a single structure can be made by sealing the resorptive defect. In the present case, we show a multidisciplinary approach where orthodontics, periodontics, and restorative dentistry were involved in treating the maxillary right central incisor (#8) of a 65-year-old patient with extensive cervical resorption, whose chief complaint was esthetics. The proposed treatment was extrusion of the tooth followed by curettage and restoration of the defect with glass ionomer cement. The patient has been followed for 15 years with no signs of recurrence, maintenance of periodontal health, and patient satisfaction with the esthetic outcome.

  5. Research methods courses as a means of developing academic general practice. Fifteen years' experience from Sweden and Denmark.

    Science.gov (United States)

    Håkansson, Anders; Beckman, Anders; Hansson, Eva Ekvall; Merlo, Juan; Månsson, Nils-Ove

    2005-09-01

    Since 1989, the authors have given courses in research methodology, and these courses are now given at six venues in southern Sweden, as well as in Denmark. The course corresponds to half a year's full-time study, with half the time devoted to lectures and studies of literature, while the rest is spent on an individual project under supervision. To enable part-time study, the course extends over 1(1/2) years. In 15 years roughly 1000 people, mainly physicians, have been given training in basic research methods. The course model has been appreciated by clinically active colleagues, who have been able to attend a course and simultaneously work with patients. Among the GPs in the region, one in five has taken this course, and one in five has then gone on to start formal PhD studies. The authors have thus succeeded in their goal of giving basic scientific schooling to many physicians and recruiting some for further research.

  6. Fifteen years of losartan: what have we learned about losartan that can benefit chronic kidney disease patients?

    Directory of Open Access Journals (Sweden)

    Elizabeth Ripley

    2010-06-01

    Full Text Available Elizabeth Ripley, Ari HirschDivision of Nephrology, Virginia Commonwealth University, Richmond, Virginia, USAAbstract: Losartan, the first AT1 receptor blocker (ARB, was FDA approved 15 years ago.During those years, researchers and clinicians have developed a growing base of knowledge on the benefits of losartan, particularly for hypertension and renal disease. These benefits include decreasing proteinuria, slowing the progression of diabetic nephropathy, controlling hypertension, and decreasing stroke risk in patients with left ventricular hypertrophy. Although many of the benefits of losartan represent a class effect for ARBs, losartan has pharmacokinetic and pharmacodynamic characteristics and effects that are unique and are not a class effect. For example, a shorter duration of action is seen with this first ARB compared with other more recently approved ARBs. Losartan also has a uricosuric effect not seen in other ARBs and attenuates platelet aggregation, which is not seen or is seen to a lesser extent with the other ARBs. This review presents the physiological effects of losartan on the kidney and discusses relevant clinical outcomes.Keywords: losartan, chronic kidney disease

  7. Increased cardiovascular mortality more than fifteen years after radiotherapy for breast cancer: a population-based study

    International Nuclear Information System (INIS)

    Roychoudhuri, Rahul; Robinson, David; Putcha, Venkata; Cuzick, Jack; Darby, Sarah; Møller, Henrik

    2007-01-01

    Breast radiotherapy as practised in the 1970s and 1980s resulted in significant myocardial exposure, and this was higher when the left breast was treated. It has been proposed that this difference might result in greater cardiovascular mortality following irradiation of the left breast when compared with the right. All cases of female breast cancer diagnosed between 1971 and 1988 and recorded on the Thames Cancer Registry database were followed up to the end of 2003 to identify cases who had died from ischaemic heart disease (IHD) or any cardiovascular disease (CVD). A proportional hazards regression analysis was performed, stratified by time since diagnosis, using as the baseline group those women with right-sided disease who did not receive radiotherapy, and adjusting for age at diagnosis. A total of 20,871 women with breast cancer were included in the analysis, of which 51% had left-sided disease. Mortality at 15+ years after diagnosis was increased in recipients of left-breast radiotherapy compared to non-irradiated women with right-sided breast cancer, both for IHD (hazard ratio 1.59; 95% confidence interval 1.21–2.08; p = 0.001) and all CVD (hazard ratio 1.27; 95% confidence interval 1.07–1.51; p = 0.006). When irradiated women with left-sided breast cancer were compared with irradiated women with right-sided breast cancer, cardiovascular mortality at 15+ years after diagnosis was raised by around 25% (IHD: hazard ratio 1.23; 95% confidence interval 0.95–1.60; p = 0.114; CVD: hazard ratio 1.25; 95% confidence interval 1.05–1.49; p = 0.014). We have found an elevation in cardiovascular mortality more than 15 years after breast radiotherapy in women diagnosed with breast cancer between 1971 and 1988. The risk was greater following irradiation of the left breast compared with the right. This confirms that radiotherapy as practised in the 1970s and 1980s has resulted in significant long-term cardiac toxicity. In absolute terms, the increase in

  8. Fifteen years of successful spread of Salmonella enterica serovar Mbandaka clone ST413 in Poland and its public health consequences

    Directory of Open Access Journals (Sweden)

    Andrzej Hoszowski

    2016-06-01

    Full Text Available In the 1990s, [i]Salmonella enterica[/i] serovar (S. Mbandaka occurred in feed and poultry in Poland. In the following years, the serovar also gained epidemiological importance in other EU countries. The objectives of current study were to evaluate the genetic relationship of contemporary S. Mbandaka with isolates originating from the beginning of the epidemics, and to assess the contribution of poultry as the source of infections in humans. Seventy S. Mbandaka isolated mainly in 2009 – 2010 from humans, poultry, food, and feed were typed with API ID32 [sup]®[/sup], MIC, plasmid profiling, PFGE, and MLST. PCR and sequencing were used to identify plasmid mediated quinolone and cephalosporin resistance mechanisms. Six biochemical profiles were identified and 59 of S. Mbandaka proved to be susceptible to the applied antimicrobials. Eight strains carried plasmids and a few of them were positive for [i]bla[/i][sub]CMY-2[/sub] and [i]qnr[/i]S1 genes. Two clusters of 15 [i]XbaI[/i]-PFGE profiles with similarity of 77.5% were found. The first cluster, gathered 7 profiles involving historical isolates and several contemporary non-human S. Mbandaka. The predominant profile in the second cluster consisted of 28 human and 1 broiler isolate. MLST analysis showed sequence type ST413 occurring among all tested isolates. The identification of close genetic relationships between S. Mbandaka of human and poultry origin indicates animals as a primal human infection route. Despite [i]Salmonella [/i]control programmes, the S. Mbandaka ST413 clone has been circulating for several years in Poland. [i]Salmonella[/i] control polices in food production chain should be continuously updated to target serovars of major epidemiological importance. Resistance noted in S. Mbandaka to such antimicrobials as fluoroquinolones and cephalosporins may hinder public health.

  9. Divergent fifteen-year trends in traditional and cardiometabolic risk factors of cardiovascular diseases in the Seychelles

    Directory of Open Access Journals (Sweden)

    Darioli Roger

    2009-06-01

    Full Text Available Abstract Objective Few studies have assessed secular changes in the levels of cardiovascular risk factors (CV-RF in populations of low or middle income countries. The systematic collection of a broad set of both traditional and metabolic CV-RF in 1989 and 2004 in the population of the Seychelles islands provides a unique opportunity to examine trends at a fairly early stage of the "diabesity" era in a country in the African region. Methods Two examination surveys were conducted in independent random samples of the population aged 25–64 years in 1989 and 2004, attended by respectively 1081 and 1255 participants (participation rates >80%. All results are age-standardized to the WHO standard population. Results In 2004 vs. 1989, the levels of the main traditional CV-RF have either decreased, e.g. smoking (17% vs. 30%, p Conclusion The levels of several traditional CVD-RF improved over time, while marked detrimental trends were observed for obesity, diabetes and several cardiometabolic factors. Thus, in this population, the rapid health transition was characterized by substantial changes in the patterns of CVD-RF. More generally, this analysis suggests the importance of surveillance systems to identify risk factor trends and the need for preventive strategies to promote healthy lifestyles and nutrition.

  10. Fifteen years of external quality assessment in leukemia/lymphoma immunophenotyping in The Netherlands and Belgium: A way forward.

    Science.gov (United States)

    Preijers, Frank W M B; van der Velden, Vincent H J; Preijers, Tim; Brooimans, Rik A; Marijt, Erik; Homburg, Christa; van Montfort, Kees; Gratama, Jan W

    2016-05-01

    In 1985, external quality assurance was initiated in the Netherlands to reduce the between-laboratory variability of leukemia/lymphoma immunophenotyping and to improve diagnostic conclusions. This program consisted of regular distributions of test samples followed by biannual plenary participant meetings in which results were presented and discussed. A scoring system was developed in which the quality of results was rated by systematically reviewing the pre-analytical, analytical, and post-analytical assay stages using three scores, i.e., correct (A), minor fault (B), and major fault (C). Here, we report on 90 consecutive samples distributed to 40-61 participating laboratories between 1998 and 2012. Most samples contained >20% aberrant cells, mainly selected from mature lymphoid malignancies (B or T cell) and acute leukemias (myeloid or lymphoblastic). In 2002, minimally required monoclonal antibody (mAb) panels were introduced, whilst methodological guidelines for all three assay stages were implemented. Retrospectively, we divided the study into subsequent periods of 4 ("initial"), 4 ("learning"), and 7 years ("consolidation") to detect "learning effects." Uni- and multivariate models showed that analytical performance declined since 2002, but that post-analytical performance improved during the entire period. These results emphasized the need to improve technical aspects of the assay, and reflected improved interpretational skills of the participants. A strong effect of participant affiliation in all three assay stages was observed: laboratories in academic and large peripheral hospitals performed significantly better than those in small hospitals. © 2015 International Clinical Cytometry Society. © 2015 International Clinical Cytometry Society.

  11. Divergent fifteen-year trends in traditional and cardiometabolic risk factors of cardiovascular diseases in the Seychelles.

    Science.gov (United States)

    Bovet, Pascal; Romain, Sarah; Shamlaye, Conrad; Mendis, Shanti; Darioli, Roger; Riesen, Walter; Tappy, Luc; Paccaud, Fred

    2009-06-26

    Few studies have assessed secular changes in the levels of cardiovascular risk factors (CV-RF) in populations of low or middle income countries. The systematic collection of a broad set of both traditional and metabolic CV-RF in 1989 and 2004 in the population of the Seychelles islands provides a unique opportunity to examine trends at a fairly early stage of the "diabesity" era in a country in the African region. Two examination surveys were conducted in independent random samples of the population aged 25-64 years in 1989 and 2004, attended by respectively 1081 and 1255 participants (participation rates >80%). All results are age-standardized to the WHO standard population. In 2004 vs. 1989, the levels of the main traditional CV-RF have either decreased, e.g. smoking (17% vs. 30%, p or =10; 11% vs. 13%, ns), whereas the prevalence of the metabolic syndrome (which integrates several cardiometabolic CVD-RF) nearly doubled (36% vs. 20%, p < 0.001). Data on physical activity and on intake of alcohol, fruit and vegetables are also provided. Awareness and treatment rates improved substantially for hypertension and diabetes, but control rates improved for the former only. Median levels of the cardiometabolic CVD-RF increased between 1989 and 2004 within all BMI strata, suggesting that the worsening levels of cardiometabolic CVD-RF in the population were not only related to increasing BMI levels in the interval. The levels of several traditional CVD-RF improved over time, while marked detrimental trends were observed for obesity, diabetes and several cardiometabolic factors. Thus, in this population, the rapid health transition was characterized by substantial changes in the patterns of CVD-RF. More generally, this analysis suggests the importance of surveillance systems to identify risk factor trends and the need for preventive strategies to promote healthy lifestyles and nutrition.

  12. From chickpeas to oil. The keys to fifteen years of hispanic-mexican economic relations (1977-1992

    Directory of Open Access Journals (Sweden)

    Santiago Forcada

    1993-07-01

    Full Text Available This article intends to analyse the evolution of economic relations between Spain and Mexico from the reestablishment of diplomatic relations taking into account both the keys to this evolution and its changes. The authors highlight three distinct periods : a boom between 1977 and 1981 ; a relapse between 1982 and 1986 and a recovery between 1987 and 1992. This division into periods takes note of an initial spectacular increase in which bilateral exchanges were multiplied up to 33 times. A five year period in which oil replaced chickpeas as the main product bought in Mexico (up to four-fifths of the total volume and in which Spanish exports multiplied themselves ten times over. Already from this first phase, the commercial balance was clearly in favour of Mexico, a fact more striking during the second period, during which Spanish imports fell up to 50% but whileher exports were reduced by two-thirds. The key was the fall in the price of oil. The continuity of Spanish oil buying in Mexico however precipitated the recovery of the third period which coincided with the signing of the General Friendship and Cooperation Agreement between both countries. In 1992 Spain regained second place as a customer of Mexico behind the United States while the joint political policies coincide in pointing out that these are two reciprocal pathways to both the EC and US markets. The authors however, sustain that the global evolution of economic blocks does not favour this vision bearing in mind that the composition of and leadership in trade between such blocks will be governed, basically, by the strategies deployed by transnational companies.

  13. Tres lustros del periodismo digital:interactividad e hipertextualidad Fifteen Years of Online Journalism. Interaction and Hypertextuality

    Directory of Open Access Journals (Sweden)

    Lizy Navarro Zamora

    2009-10-01

    Full Text Available En el 2009 se cumplen 15 años del inicio del periodismo en Internet. Las características del periodismo han evolucionado con la convergencia digital. La interactividad e hipertextualidad son dos elementos que configuran la esencia de la relación entre periodismo y tecnologías de la información y comunicación. En esta investigación se realizó el análisis del perfil y elementos del periodismo digital, así como el emisor y receptor de este proceso comunicativo. El corpus de la investigación fueron diez medios internacionales y los siguientes medios nacionales: 100 periódicos, 30 cadenas de televisión y 30 emisoras de radio que desde hace más de 10 años están en Internet. También se realizó el envío de 2.000 correos electrónicos a un corpus de otros tantos periodistas: reporteros, editorialistas y webmaster. On-line journalism completes 15 years of existence in 2009. The characteristics of journalism have evolved with information technology. Interaction and hypertextuality are two elements that configure the essence of the relationship between journalism and new information and communication technologies. This research analyzes the profile and elements of on-line journalism, as well as the transmitter and receiver in this communication process. The research corpus is 10 international media and the following Mexican media: 100 newspapers, 30 television stations and 30 radio stations, all with more than 10 years’ on-line experience. Also, two hundred e-mails were sent out to journalists, leader writers and webmasters.

  14. Introduction

    DEFF Research Database (Denmark)

    Ashbee, Edward; Dumbrell, John

    2017-01-01

    The introduction sets a framework for subsequent chapters by considering theories of change and the extent to which there was consequential change during the Obama years. It draws upon earlier scholarship to suggest that although there certainly was no “transformation” (when new interests secure...... Congress. Nonetheless, although recent literature within historical institutionalism has stressed the importance of incrementalism, it is vulnerable to rollback. Against this background, the introduction sets questions about the character of change that are addressed in the case studies included...

  15. Introduction

    NARCIS (Netherlands)

    Binsbergen, van W.M.J.

    2003-01-01

    This volume brings together fifteen essays investigating aspects of interculturality. Published between 1969 and 2002, the essays operate at the borderline between anthropology and intercultural philosophy. Ethnographic data are derived from field research carried out in Tunisia, Zambia and

  16. Volume measurement system for plutonium nitrate solution and its uncertainty to be used for nuclear materials accountancy proved by demonstration over fifteen years

    International Nuclear Information System (INIS)

    Hosoma, Takashi

    2010-10-01

    An accurate volume measurement system for plutonium nitrate solution stored in an accountability tank with dip-tubes has been developed and demonstrated over fifteen years at the Plutonium Conversion Development Facility of the Japan Atomic Energy Agency. As a result of calibrations during the demonstration, it was proved that measurement uncertainty practically achieved and maintained was less than 0.1% (systematic character) and 0.15% (random) as one sigma which was half of the current target uncertainty admitted internationally. It was also proved that discrepancy between measured density and analytically determined density was less than 0.002 g·cm -3 as one sigma. These uncertainties include effects by long term use of the accountability tank where cumulative plutonium throughput is six tons. The system consists of high precision differential pressure transducers and a dead-weight tester, sequentially controlled valves for periodical zero adjustment, dampers to reduce pressure oscillation and a procedure to correct measurement biases. The sequence was also useful to carry out maintenances safely without contamination. Longevity of the transducer was longer than 15 years. Principles and essentials to determine solution volume and weight of plutonium, measurement biases and corrections, accurate pressure measurement system, maintenances and diagnostics, operational experiences, evaluation of measurement uncertainty are described. (author)

  17. Prevalence and contributing factors to attention deficit hyperactivity disorder: A study of five- to fifteen-year-old children in Zhabei District, Shanghai

    OpenAIRE

    Jin, Wenlan; Du, Yasong; Zhong, Xiangyang; David, Coghill

    2013-01-01

    Introduction This work aims to understand the features among 5- to 15-year-old children with attention deficit hyperactivity disorder (ADHD) in Zhabei District in Shanghai. Methods Children with ADHD were studied using general background questionnaire, ADHD symptom rating questionnaire, and cluster-stratified sampling. A total of 9,900 valid questionnaires were utilized in this study. We conducted diagnostic interviews with suspected ADHD children and their parents using the criteria of the D...

  18. Introduction

    Directory of Open Access Journals (Sweden)

    Deborah Hauptmann

    2014-08-01

    Full Text Available Over the past fifteen years most advanced education programmes within Schools of Architecture have been questioning the parameters and requirements of doctoral research both in terms of content and form. This double issue of Footprint was motivated by the question of where the field stands today. Footprint 10|11 presents nine contributions from both recently defended and developing PhD candidates from a variety of institutions. The diversity of their work, as well as the similarities found in the submissions, offers a partial view into research topics currently addressed in PhD programmes within Schools of Architecture. In addition to the nine papers by PhD researchers, we have included a paper by Andrew Leach that we believe provides an overview of the general state of contemporary architecture research. Leach makes an appeal to refrain from making all research operational. At a time when the application of research and its economic value seem to form the primary criteria for judging value, this appeal should not be taken lightly.

  19. Introduction

    DEFF Research Database (Denmark)

    Seeberg, Peter

    2015-01-01

    states, the Introduction emphasizes the continued relevance of focusing on a repoliticized MENA reality. The Middle East is still on the move away from the established image of unshakeable authoritarianism attributed to the region, which made the upgrading authoritarianism paradigm seem forever relevant......The Introduction briefly presents the ideas behind this collection of articles, namely to analyze popular mobilization and the role of civil society, political parties, and regional organizations in relation to the developments in the Middle East and North Africa (MENA) over the last years......, and to discuss theoretical approaches and paradigms of relevance for the analysis of these new regional dynamics. The MENA region experienced, in connection with and following the Arab uprisings, a hitherto unseen popular mobilization. Despite the recent highly problematic situation in several Middle Eastern...

  20. Introduction

    DEFF Research Database (Denmark)

    Kørnøv, Lone; Lund, Henrik; Remmen, Arne

    2004-01-01

    The chapter gives an introduction to the book "Environmental planning and management : tools for a sustainable development".......The chapter gives an introduction to the book "Environmental planning and management : tools for a sustainable development"....

  1. Introduction

    DEFF Research Database (Denmark)

    Høgfeldt Hansen, Leif

    2016-01-01

    This introduction to South Korean architecture gives an overall view of the architecture done in the country in historic times as well as a general introduction to the culture of the country.......This introduction to South Korean architecture gives an overall view of the architecture done in the country in historic times as well as a general introduction to the culture of the country....

  2. Long term monitoring at Solfatara of Pozzuoli (Campi Flegrei, Italy): 1998-2014, fifteen years of soil CO2 flux measurement.

    Science.gov (United States)

    Cardellini, Carlo; Chiodini, Giovanni; Rosiello, Angelo; Bagnato, Emanuela; Avino, Rosario; Frondini, Francesco; Donnini, Marco; Caliro, Stefano

    2015-04-01

    With a flux of deeply derived fluids of ~5000 t/d and an energetic release of ~100 MW Solfatara of Pozzuoli is one of the largest studied volcanic-hydrothermal system of the world. Since 1998, soil CO2 flux surveys where performed using the accumulation chamber method over a large area (1.45 km2), including the volcanic apparatus and its surroundings. The statistical elaboration of CO2 flux, also coupled with the investigation of the CO2 efflux isotopic composition, allowed to characterize both the CO2 flux connected to by biological activity in the soil and that feed to the degassing of the hydrothermal system. A geostatistical elaboration of CO2 fluxes based on sequential Gaussian simulations, allowed to define the spatial structure of the degassing area, pointing out the presence of a well defined diffuse degassing structure interested by the release of deeply derived CO2 (Solfatara DDS). Solfatara DDS results well correlated to volcanic and tectonic structures interesting the crater area and the eastern area of Pisciarelli. With the same approach the total amount of CO2 release was estimated to range between 754 t/d and 1530 t/d in the last fifteen year (with an error in the estimate varying between 9 and 15 %). Also the extension of the DDS experienced relevant variations varying between 4.5x105 m2 to 12.3 x105 m2. In particular two major changes occurred in the extension of the DDS, the first consisted in its doubling in 2003-2004 and the second in further enlargement of ~ 30% in 2011-2012, the last occurring after period of decreasing trend which interrupted 4-5 years of relative stability. These variations mainly occurred external to the crater area in correspondence of a NE-SW fault system where fluxes increased from background to values typical of the endogenous source. The first event was previously correlated with the occurrence in 2000 of a relatively deep seismic swarm, which was interpreted as the indicator of the opening of an easy-ascent pathway

  3. Australia’s Ongoing Legacy of Asbestos: Significant Challenges Remain Even after the Complete Banning of Asbestos Almost Fifteen Years Ago

    Science.gov (United States)

    Soeberg, Matthew; Vallance, Deborah A.; Keena, Victoria

    2018-01-01

    The most effective way of reducing the global burden of asbestos-related diseases is through the implementation of asbestos bans and minimising occupational and non-occupational exposure to respirable asbestos fibres. Australia’s asbestos consumption peaked in the 1970s with Australia widely thought to have had among the highest per-capita asbestos consumption level of any country. Australia’s discontinuation of all forms of asbestos and asbestos-containing products and materials did not occur at a single point of time. Crocidolite consumption ceased in the late 1960s, followed by amosite consumption stopping in the mid 1980s. Despite significant government reports being published in 1990 and 1999, it was not until the end of 2003 that a complete ban on all forms of asbestos (crocidolite, amosite, and chrysotile) was introduced in Australia. The sustained efforts of trade unions and non-governmental organisations were essential in forcing the Australian government to finally implement the 2003 asbestos ban. Trade unions and non-government organisations continue to play a key role today in monitoring the government’s response to Australian asbestos-related disease epidemic. There are significant challenges that remain in Australia, despite a complete asbestos ban being implemented almost fifteen years ago. The Australian epidemic of asbestos-related disease has only now reached its peak. A total of 16,679 people were newly diagnosed with malignant mesothelioma between 1982 and 2016, with 84% of cases occurring in men. There has been a stabilisation of the age-standardised malignant mesothelioma incidence rate in the last 10 years. In 2016, the incidence rate per 100,000 was 2.5 using the Australian standard population and 1.3 using the Segi world standard population. Despite Australia’s complete asbestos ban being in place since 2003, public health efforts must continue to focus on preventing the devastating effects of avoidable asbestos-related diseases

  4. Changes in educational inequalities in Poland. Comments on Zbigniew Sawiński’s article “Education reform and inequality: fifteen years of new lower secondary schools in Poland”

    Directory of Open Access Journals (Sweden)

    MICHAŁ SITEK

    2017-06-01

    Full Text Available In his text published in Edukacja, 141(2, 2017 („Education reform and inequality: fifteen years of new lower secondary schools in Poland”, Zbigniew Sawiński analyses data from the 2000 to 2012 editions of the OECD PISA study and argues that lower secondary school reform has not reduced educational inequalities in Poland. The importance of students’ social origin remained at the same level as before the reform, the impact of social origin on the choice of type of secondary school remained the same, and an increasing differentiation of lower secondary schools did not lead to an increase in educational inequalities. I present methodological arguments and the results of a re-analysis of PISA data, indicating changes in wider educational inequalities. Between 2000 and 2012: (a the strength of association in the performance of 15-year-olds with the socio-economic status of students’ families did not change, but (b the variation of results decreased, which was mainly due to the improved performance of the lowest performing students, (c the differences between students of high and low socio-economic status decreased, (d the influence of social origin on the choice of the type of upper secondary school decreased. The effects of socio-economic status on upper secondary school choice is largely direct: it is not mediated by the educational achievements of students. The commentary also highlights the complexity of lower secondary school reform, which was not limited to the introduction of such schools. I indicate the role of factors that make it difficult to interpret the results of the reform in causal terms – particularly the role of unobserved variables related to the changes in the learning environments of subsequent cohorts of students.

  5. A questão racial na política brasileira (os últimos quinze anos The racial question in Brazilian politics (the past fifteen years

    Directory of Open Access Journals (Sweden)

    Antonio Sérgio Alfredo Guimarães

    2001-11-01

    Full Text Available Neste artigo, analiso o modo como a questão racial tem marcado a política brasileira nos últimos quinze anos. Começo expondo o que significou a idéia de democracia racial no processo de construção da nacionalidade brasileira, para depois, com a brevidade que o espaço exige, resenhar os estudos sobre o comportamento eleitoral dos negros brasileiros e tratar da emergência de movimentos sociais negros e de sua incorporação ao sistema político. Meu entendimento é que devemos ver na "democracia racial" um compromisso político e social do moderno estado republicano brasileiro, que vigeu, alternando força e convencimento, do Estado Novo de Vargas até o final da ditadura militar. Tal compromisso, hoje em crise, consistiu na incorporação da população negra brasileira ao mercado de trabalho, na ampliação da educação formal, enfim na criação das condições infra-estruturais de uma sociedade de classes que desfizesse os estigmas criados pela escravidão. A imagem do negro enquanto povo comum e o banimento, no pensamento social brasileiro, do conceito de "raça", substituído pelos de "cultura" e "classe social", são as expressões maiores desse compromisso.In this article, I analyze how the racial question has marked Brazilian politics in the past fifteen years. I start by showing what the idea of racial democracy meant to the process of reconstruction of the Brazilian nationality, and go on to review the studies on the voting behaviour of the Brazilian Black population and discuss the emergence of Black social movements and their incorporation into the political system. I understand that we must see "racial democracy" as a political and social compromise of the Brazilian modern republican state, which was in power from the Vargas' New State until the end of the military dictatorship. This compromise which at present is in crisis, consisted of the incorporation of the Brazilian Black population into the work market, of the

  6. Introduction

    DEFF Research Database (Denmark)

    Jensen, Rasmus Thybo; Moran, Dermot

    2012-01-01

    An introduction to a special issue of Phenomenology and the Cognitive Sciences dedicated to empathy and the direct perception approach to other minds......An introduction to a special issue of Phenomenology and the Cognitive Sciences dedicated to empathy and the direct perception approach to other minds...

  7. Introduction

    DEFF Research Database (Denmark)

    Søbjerg, Lene Mosegaard

    2016-01-01

    Introduction to anthology which provides the theoretical basis of an Erasmus+ project involving marginalised young people, practitioners, students and academics in co-creating a teaching module for the social professions.......Introduction to anthology which provides the theoretical basis of an Erasmus+ project involving marginalised young people, practitioners, students and academics in co-creating a teaching module for the social professions....

  8. Introduction

    International Nuclear Information System (INIS)

    Toropila, M.

    2006-01-01

    In this introduction to The Third Radiobiological Conference author give a short retrospective review of reactor accidents (26 th April 1986, Chernobyl NPP, 1979 in Three Mile Island). In former Czechoslovakia an attention has been paid to the questions of the effects of radiation on organism from the 1950's. After discharge of Commonwealth the Radiobiological Association. that facilitated interchange of the results of research work among various national and foreign institutions. was also abolished. After establishment of the autonomous Slovak Republic the University of Veterinary Medicine (UVM) in Kosice in collaboration with Pavol Jozef Safarik University in Kosice linked to tradition of radiobiology and organized the the First Radiobiological Conference in Slovakia. At this conference 37 lectures of home and 9 of Czech authors were presented. At the end of conference the agreement was made to held this conference every second year. The 2 nd Radiobiological Conference was held in 2004 at the occasion of the 55 st anniversary of the UVM establishment in Kosice. The 3 rd Conference held on 25 tb May 2006 in UVM in Kosice was inscribed to the 20 th anniversary of Chernobyl disaster. Selected articles dealing with this problem create contents of Supplement inscribed to the 50 th anniversary of the scientific journal Folia Veterinaria

  9. Introduction

    International Nuclear Information System (INIS)

    Kadirov, A.Kh.; Khaydarov, K.Kh.; Giyosov, A.Sh.

    2000-01-01

    In the introduction authors describe book in general and in particular describe the ways and methods of direct synthesis on the base of different derivatives of cholanic acids and receiving of line of corresponding ethers which have practical properties

  10. Introduction

    DEFF Research Database (Denmark)

    Henkel, Anna; Åkerstrøm Andersen, Niels

    2015-01-01

    An introduction is presented in which the authors discuss various reports within the issue on topics including the concept of responsibility, the discourse about responsibility, and the attribution of responsibility in an interdisciplinary context.......An introduction is presented in which the authors discuss various reports within the issue on topics including the concept of responsibility, the discourse about responsibility, and the attribution of responsibility in an interdisciplinary context....

  11. Introduction

    Directory of Open Access Journals (Sweden)

    Donatella Abbate Badin

    2011-08-01

    Full Text Available The introduction to the monographic section Italy-Ireland: Cultural Inter-Relations, gives a brief account of how this part of the journal tries to fill a gap in transcultural studies by investigating the hitherto relatively underexplored relationship of Ireland with Italy. The editors argue that the topic deserves special attention because throughout the centuries, owing to a shared religion and Ireland’s colonial and postcolonial status, a special relationship was established. Without neglecting the many contributions published on this topic over the past thirty years, the papers collected in this first issue of SIJIS offer an overall view of the relations between Italy and Ireland from the Middle Ages to the present day demonstrating this special relationship. The opening essay, drawing an ample and interdisciplinary panorama of the representations of Ireland in Italy over the centuries, and  the concluding one, introducing new issues and suggestions for further investigations, frame seven papers organized thematically in subsections.  The translation studies section highlights some specific problems presented to the translator because of the Irish nature of the translated texts. Exploration of the links between some major figures and Italy opens up new perspectives even regarding much studied figures such as Joyce while  the time-honoured comparative method of studying influences yields ground-breaking insights as in the study of links between Commedia dell’Arte and Clarke or Mahon and Pasolini. Representations of Italy and  the presence of Italian settings and characters acquire  a specific Irish edge in the writings of Synge, Lady Morgan and Edward Maturin especially when both countries were still in search  of their identities.

  12. Introduction

    International Nuclear Information System (INIS)

    Ainul Hayati Daud; Hazmimi Kasim

    2010-01-01

    Since the Atoms for Peace program in 1950s, peaceful applications of nuclear technology has been at the forefront of the development of many countries. In Malaysia, the development of nuclear technology began in earnest with the setting-up of Malaysian Nuclear Agency (Nuclear Malaysia) in 1972, then known as CRANE. More than thirty years later, today, the technology has gained footing and made impact to the development of the country. Her role in regional and international scenes in nuclear-related matters and nuclear technology was noticed and being given due attention. It is time to take stock of this development and assess its impact upon which further developments can be planned and strategized. That was the genesis of this study. This chapter presents a review of the status and development of nuclear technology globally and in Malaysia to provide a background for the report and the study. This is followed by an introduction to the study: its objectives, scope, methods of research, total population, sampling frame, selection procedures, target groups and data analysis. The chapter concludes with a guide to the organization of this report. The study was conducted with the aim of evaluating the impact and contribution of nuclear technology to socio-economic development of the country. It is also expected to identify issues and challenges faced by users of this technology. Even though the applications of nuclear technology encompass diverse human endeavors, this study focuses only in industrial, medical and agriculture sectors. The applications of nuclear technology in both public agencies and private companies in those sectors are considered. This is the first time such a study is being undertaken in Malaysia, and as a starting point, the three year period spanning 2006-2008 are taken as the time frame for discerning trends of nuclear technology development in the country. This study was also in an indirect sense motivated by similar studies conducted in the USA

  13. Introduction

    DEFF Research Database (Denmark)

    Gjerdrum Pedersen, Esben Rahbek; Thusgaard Pedersen, Janni

    2013-01-01

    An introduction is presented in which the editors discuss various reports within the issue on topics including the shared value concept in the education and business, the role of corporate foundations in establishing cross-sector partnerships, and the mechanisms of governance in the cross...

  14. Introduction

    DEFF Research Database (Denmark)

    Pop, Paul; Alistar, Mirela; Stuart, Elena

    2015-01-01

    This chapter presents an introduction to the microfluidics field and microfluidic biochips. We discuss the main fluid propulsion principles used by modern microfluidic platforms, with a focus on “digital” microfluidic biochips, which are the topic of this book. Digital microfluidic biochips...

  15. Introduction

    DEFF Research Database (Denmark)

    Barwell, Richard; Clarkson, Philip; Halai, Anjum

    2016-01-01

    This chapter provides the introduction to this ICMI Study 21 volume. It includes: a discussion of the place of this study and its topic within ICME; a discussion of what is meant by the study title; and a brief historical account of research on this topic in mathematics education. The chapter also...

  16. Introduction

    DEFF Research Database (Denmark)

    Schmidt, Johannes Dragsbæk; Berg, Torsten Rødel

    2012-01-01

    The chapter includes a discussion about the play by Henrik Ibsen from 1879, A Doll's House, how it still proves to be relevant today to gender relations not only in Denmark but in Nepal as well. The introduction explains how Ibsen's play inspired two theater directors from Denmark and Nepal...

  17. Introduction

    International Nuclear Information System (INIS)

    Raeder, J.

    1975-01-01

    The introduction to this monography gives a brief survey of the history of the MHD generator, outlines the fundamental questioning of the research concerned and then deals with the combustion gas MHD generator research programme of the working society MPI for plasma physics (IPP)/Maschinenfabrik Augsburg-Nuernberg AG (M.A.N.). (GG/LH) [de

  18. Introduction

    NARCIS (Netherlands)

    Dieci, R.; He, X.-Z.; Hommes, C.; Dieci, R.; He, X.-Z.; Hommes, C.

    2014-01-01

    This introduction summarises the main contributions of 18 chapters in this book, in addition to two articles (Part I) reflecting Carl's view on a broad range of research-related issues originally published in Italian. The contributed chapters cover the latest developments in Nonlinear Economic

  19. Introduction

    NARCIS (Netherlands)

    Doreian, Patrick; Stokman, Frans N.

    2001-01-01

    Introduction to: The proceedings of a conference that was held on the analysis of repeated cross sections at the University of Nijmegen on June 15±16, 2000. This two-days meeting was attended by 75 participants from seven different countries (AUS, B, F, GER, NL, USA, UK) and from a wide array of

  20. Introduction

    NARCIS (Netherlands)

    Salverda, W.; Nolan, B.; Checchi, D.; Marx, I.; McKnight, A.; Tóth, I.G.; van de Werfhorst, H.; Salverda, W.; Nolan, B.; Checchi, D.; Marx, I.; McKnight, A.; Tóth, I.G.; van de Werfhorst, H.

    2014-01-01

    This chapter provides the introduction to a collection of 11 comparative chapters and a concluding chapter which, based on 30 country studies (25 European, USA, Canada, Australia, Japan, Korea; reported in the companion volume Nolan et al. 2013), look at the evolution of inequalities, their social

  1. Introduction

    DEFF Research Database (Denmark)

    Petersen, Nils Holger; Sandbeck, Lars; Solten, Therese Bering

    2013-01-01

    Introduction to the Special Issue of Literature and Theology publishing articles based on selected papers from the international conference of the International Society for Religion, Literature and Culture (ISRLC) conference held at the Theological Faculty of the University of Copenhagen 19...

  2. Introduction

    DEFF Research Database (Denmark)

    Bandak, Andreas; Janeja, Manpreet Kaur

    2018-01-01

    This introduction foregrounds waiting as a central analytical category to make way for ethnographic attention to uncertain interplays between doubting and hoping. Using a range of focused ethnographies which explore the centrality of waiting in social life, it offers a critical lens...

  3. Introduction

    DEFF Research Database (Denmark)

    Schmidt, Johannes Dragsbæk; Rasiah, Rajah

    2010-01-01

    This is a very interesting book. It is topical and is one of the few volumes that attempts to treat Southeast Asia as an integrated whole. The editors are methodologically ambitious, and they skillfully integrate a very large amount of diverse material in their introduction. I imagine that the bo...... working on the economics and development of Southeast Asia....

  4. Introduction

    International Nuclear Information System (INIS)

    Jacquinot, J.

    1997-01-01

    An introduction to the symposium on nuclear fusion and the CEA researches on magnetic confinement, is presented, with a review of the future energy capacities that fusion could deliver, the technological developments on superconductors, robots, etc. that will assist fusion development, and the european and international cooperation programs on the subject

  5. Introduction

    International Nuclear Information System (INIS)

    Van Walle, E.

    2007-01-01

    The introduction to the annual report 2006 of the Belgian Nuclear Research Centre SCK-CEN highlights the reorganisation of SCK-CEN that became effective in 2006. An overview is given of the principal activities of Institute for Nuclear Materials Science, the Institute for Advanced Nuclear Systems, the Institute for Environment, Health and Safety and the Institute for Communication, Services and Administration

  6. Introduction

    DEFF Research Database (Denmark)

    Schubart, Rikke

    2017-01-01

    This special issue of the journal Refractory explores identity in the Penny Dreadful.The introduction introduces the show, themes and the six articles. In Season Two of television horror-drama, Penny Dreadful (Showtime/Sky, 2014-16), Ethan Chandler (Josh Hartnett), American sharpshooter and werew......This special issue of the journal Refractory explores identity in the Penny Dreadful.The introduction introduces the show, themes and the six articles. In Season Two of television horror-drama, Penny Dreadful (Showtime/Sky, 2014-16), Ethan Chandler (Josh Hartnett), American sharpshooter...... and werewolf, asks Vanessa Ives (Eva Green), a British heiress with supernatural powers and a troubled past, what happens when the monsters inside of them are released? She says: “We’re most who we are. Unrestrained. Ourselves.” Summing up a central concern of the series, she confirms the view of its creator...

  7. Introduction

    OpenAIRE

    Brake, Laurel; Mussell, James

    2013-01-01

    When W. T. Stead died on the Titanic he was the most famous Englishman on board. A mass of contradictions and a crucial figure in the history of the British press, Stead was a towering presence in the cultural life of late-Victorian and Edwardian society. In this introduction, we consider Stead as a ‘mass of contradictions’ and offer a few ways in which his prodigious output and activity might be understood.

  8. Introduction

    Directory of Open Access Journals (Sweden)

    Laurel Brake

    2013-04-01

    mso-fareast-language:JA;} When W. T. Stead died on the 'Titanic' he was the most famous Englishman on board. A mass of contradictions and a crucial figure in the history of the British press, Stead was a towering presence in the cultural life of late-Victorian and Edwardian society. In this introduction, we consider Stead as a ‘mass of contradictions’ and offer a few ways in which his prodigious output and activity might be understood.

  9. Introduction

    DEFF Research Database (Denmark)

    Høst, Jeppe Engset

    2015-01-01

    This chapter introduces the notion and theme of market-based fisheries management. The introduction of market mechanisms to distribute and manage fishing quota has internationally occurred since the 1980s but is increasingly on the political agenda. As privatization and transferability are promoted...... internationally, and by big players, it becomes even more crucial to understand its social and environmental implications. This chapter looks at the broader lines in the fisheries research and discusses the diverging views on market-based fisheries management. On one side market mechanisms are promoted...... for efficiency and fleet adaptation, and on the other, quota markets are accused of causing concentration and disturbing social relations....

  10. Introduction

    International Nuclear Information System (INIS)

    Davies, L.M.; Ianko, L.

    1998-01-01

    As a result of the popularity of the Agencies report 'Neutron Irradiation Embrittlement of Reactor Pressure Vessel Steels' of 1975, it was decided that another report on this broad subject would be of use. In the introduction the historic context is established, spanning a bow from the first sustained fission reactor in 1942 to contemporary developments. The subjects 'Irradiation Effects on Mechanical Properties', 'Neutron Fluence', 'Irradiation Effect Trends', 'Empirical Modelling of Irradiation Effects' and 'Mechanical Modelling' are addressed. There are also some remarks about the current state of the art, the migration of irradiation effects and about international programmes

  11. Introduction

    DEFF Research Database (Denmark)

    Peder Pedersen, Claus; Dehs, Jørgen

    2013-01-01

    Introduction to When Architects and Designers Write / Draw / Build / ? This anthology highlights the potentials and challenges for research in architecture and design. The included essays are based on papers given at a symposium held at the Aarhus School of Architecture in 2011 and contain a number...... of topical positions ranging from the activist and academic to practice-based and artistically-based research by international and Danish researchers. The anthology is aimed at architects and designers, as well as others with an interest in the discussion of the concept of research in the fields...

  12. Introduction

    DEFF Research Database (Denmark)

    de Goede, Marieke; Leander, Anna; Sullivan, Gavin

    2016-01-01

    This articles introduces the special issue on ‘The Politics of the List.’ We observe that lists proliferate as a technique of governance across multiple domains, including health, security, and commerce. We argue that it is important to take seriously the form and technique of the list itself...... and engage the knowledge practices, governance effects and ways of ordering the world that the list format enables. In other words, the special issue seeks to ‘remain in the register of the list,’ to unpack its technological arrangements and juridical power. This introduction sets out the key themes...

  13. Introduction

    International Nuclear Information System (INIS)

    2000-01-01

    In the Introduction a brief review on application of high-current electron beams (HEB) and powerful pulse ion beams (PPB) is given. It is noted that at present the following principal trends on HEB and PPB application in technologies are formed: production of super-dense plasma for controlled thermonuclear synthesis; implantation and annealing of semiconductors; modification of metals and alloys properties: strength, tribo-technical and anticorrosion ones; synthesis of new composite materials, including metastable phases and compounds; manufacture of thin films and coverings with preset structure and properties by means of ablation plasma deposition; cleaning, polishing and glancing of surfaces; synthesis of ultra-disperse and nano-sized powders; destruction and cutting of solid materials

  14. Introduction

    Science.gov (United States)

    Kirby, Evan N.

    2018-06-01

    Dwarf galaxies are excellent laboratories of chemical evolution. Many dwarf galaxies have simple star formation histories with very low average star formation rates. These conditions simplify models of chemical evolution and facilitate the identification of sites of nucleosynthesis. Dwarf galaxies also host extremely metal-poor stars, which sample the ejecta of the first generations of supernovae in the universe. This meeting-in-a-meeting, "Stellar Abundances in Dwarf Galasxies," will recognize the importance of dwarf galaxies in learning about the creation and evolution of the elements. Topics include: * the most metal-poor stars * the connection between dwarf galaxies and the Milky Way halo * dwarf galaxies as the paragons of r-process nucleosynthesis * modern techniques in stellar abundance measurements * recent advances in chemical evolution modelingI will give a very brief introduction to set the stage for the meeting.

  15. Introduction

    International Nuclear Information System (INIS)

    2002-01-01

    In the Introduction a common data about the monograph are presented. It is noted that results of α-particles elastic and inelastic scattering angular distribution with energies 40.0 and 50.1 MeV on 90,94 Zr carried out on the Kazakhstan isochronous cyclotron U-150M. A new data on total reaction cross sections at α-particles energies 96(1) MeV and 3 He ions 95(1) MeV on 90 Zr isotope, obtained on the Kiev isochronous cyclotron U-240 are given. Within framework of unified approach the experimental data analysis for α-particles quasi-elastic scattering with energies 35.4, 40.0 and 50.1, 65.0 MeV on odd zirconium isotopes as well as their reaction total cross sections is carried out. With use of α-particles scattering at low and middle energies the excited states transitions isospin character for odd tin isotopes is studied in detail with application of up-to date analysis methods. The monograph consists of introduction, four chapters and Conclussion. The chapters are as follows: (1) Experimental measurement methods of differential and total reaction cross sections with complicated particles at low and middle energies; (2) Macroscopic and semi-microscopic optical-potential approaches; (3) Peculiarities of experimental angular distribution of alpha particles at energies up to 12.5 MeV/nucleon, total reaction cross sections and results their optical potential analysis; (4) Structure characteristics of odd-odd nuclei and their comparative analysis

  16. Changes in educational inequalities in Poland. Comments on Zbigniew Sawiński’s article “Education reform and inequality: fifteen years of new lower secondary schools in Poland”

    OpenAIRE

    MICHAŁ SITEK

    2017-01-01

    In his text published in Edukacja, 141(2), 2017 („Education reform and inequality: fifteen years of new lower secondary schools in Poland”), Zbigniew Sawiński analyses data from the 2000 to 2012 editions of the OECD PISA study and argues that lower secondary school reform has not reduced educational inequalities in Poland. The importance of students’ social origin remained at the same level as before the reform, the impact of social origin on the choice of type of secondary school remained th...

  17. Introduction

    NARCIS (Netherlands)

    de Wilde, M.

    2008-01-01

    This year, on December 10, it will be exactly 60 years since the United Nations General Assembly unanimously adopted the Universal Declaration of Human Rights. The Declaration's aim was togive all ‘members of the human family', regardless of sex, race, nationality, and class, legal protection

  18. Introduction

    Directory of Open Access Journals (Sweden)

    Jonathan Carson

    2011-08-01

    Full Text Available

    Abstract: Written as Carson & Miller, collaborative artists who explore narrative and the places where narrative intersects with material culture and everyday experience, this introduction presents the stakes of the larger project that entails the exhibition The Story of Things (2009, the conference The Story of Things: reading narrative in the visual (2010 and the double issue of Image (& Narrative. It mainly focuses on the interdisciplinary approaches to the relationship between object and storytelling.

     

    Résumé: Portant la double signature de Carson & Miller, un duo d'artistes avec un intérêt particulier pour la narration et les rapports entre les interaction entre culture ordinaire et  manières de raconter, cette introduction présente les enjeux du projet plus large qui regroupe une exposition

  19. Introduction

    International Nuclear Information System (INIS)

    Zapata, F.; Garcia-Agudo, E.; Ritchie, J.C.; Appleby, P.G.

    2002-01-01

    Soil erosion and associated sedimentation are natural processes caused by water, wind and ice. Several of man's activities such as deforestation, overgrazing, changes in land use, and non-sustainable farming practices tend to accelerate soil erosion. Soil erosion and sedimentation cause not only on-site degradation of a non-renewable natural resource, but also off-site problems such as downstream sediment deposition in fields, floodplains and water streams. These problems and concern over the degradation of the landscape by erosion, and their impacts on soil fertility and crop productivity in agricultural land, water pollution, and sedimentation in lakes, reservoirs, and floodplains are well documented. Global estimates of economic damage from soil erosion and sedimentation have also been made. Recent focus on sustainability issues has resulted in increased attention on soil-degradation problems, in particular soil erosion and sedimentation. In view of increasing water scarcity and limited land resources to feed an ever-growing world population, there is an urgent need to obtain reliable quantitative data on the extent and rates of soil erosion worldwide to provide a more comprehensive assessment of the problem and to underpin the selection of effective soil-conservation technologies and sedimentation remediation strategies, including assessment of their economic and environmental impacts. This chapter describes the use of fallout 137 Cs as a tracer for measuring soil erosion and sedimentation, and the potential use of other radionuclides such as 210 Pb, and 7 Be for these studies. It provides an overview of the 137 Cs technique describing key assumptions and requirements, and advantages and limitations of the technique. Also, applications, recent developments, and future trends of the technique are covered. The chapter is completed with an introduction to the handbook and a list of selected references

  20. Introduction

    Directory of Open Access Journals (Sweden)

    Anuparna Mukherjee

    2017-04-01

    Full Text Available The city as a mosaic of anarchic diversity and messy contradictions has always been a rich source of inspiration for practitioners of creative arts. Writers, painters, planners, photographers, performers have deemed the city as the loci of their desire, conflict, passion and memory to chart the minutes of quotidian life in various intricate forms and configurations. “The city came into being when a surplus of food allowed a diversity of tasks”, Lehan asserts in his introduction to The City in Literature. “Diversity is a key to urban beginnings and continuities, and diversity is also the snake in the urban garden, challenging systems of order and encouraging disorder and chaos” (8. As an eclectic site of cultural friction and contamination that simultaneously oscillates between polarities of belonging and non-belonging, order and chaos, the city unlocks myriad windows to the chroniclers of urban realities. The cities in their perpetual making and dismantling, bear an impression of what Amit Chaudhuri terms in a recent talk as the “unfinished-ness” in the context of modern cities[1]. The “unfinished” is a slippery term as Chaudhuri explains, while it may suggest the Modernist artists’ proclivity towards dereliction, ruin or fragmentation in metropolitan landscape, it also speaks of the “half-made”[2], the backward, or the liminal spaces within an urban conurbation. However, this “unfinished-ness” or the fact that “cities are not finished products” as Chaudhuri posits, is also indicative of their “radical openness” and their inexhaustible potentials for reinventing themselves.

  1. Introduction

    Directory of Open Access Journals (Sweden)

    Alfred Hornung

    2012-01-01

    Full Text Available Forty years after the assassination of Dr. Martin Luther King, Jr., the charismatic leader of the civil rights movement, Barack H. Obama was elected the first African American president of the United States of America in 2008. Although U.S. Attorney General Robert Kennedy had predicted in 1961 that a black person could be president like his brother “in the next thirty or forty years,” nobody really expected this kind of victory to come true.

  2. Introduction

    NARCIS (Netherlands)

    Abubakar Ali, A.; Van De Vijver, Fons J R

    2017-01-01

    In 2015, it was estimated that 41% of Africa’s population were children less than 15 years of age. Most of these children are exposed to multiple risk factors which may compromise their developmental outcomes. It is therefore important to develop intervention programs and strategies to address

  3. Introduction

    NARCIS (Netherlands)

    Heuven, Vincent J. van; Quené, Hugo

    "Siebout Govaert Nooteboom (Sieb, [sip]) was born 65 years ago (19 April, 1939) in Makassar on the isle of Celebes (now Sulawesi), in the former Dutch East Indies, which is now part of the Republik Indonesia. Nooteboom obtained obtained a BA degree (kandidaats-examen, in 1963) in Dutch Language

  4. Fifteen-year trend in information on the World Wide Web for patients with rheumatoid arthritis: evolving, but opportunities for improvement remain.

    Science.gov (United States)

    Castillo-Ortiz, Jose Dionisio; de Jesus Valdivia-Nuno, Jose; Ramirez-Gomez, Andrea; Garagarza-Mariscal, Heber; Gallegos-Rios, Carlos; Flores-Hernandez, Gabriel; Hernandez-Sanchez, Luis; Brambila-Barba, Victor; Castaneda-Sanchez, Jose Juan; Barajas-Ochoa, Zalathiel; Suarez-Rico, Angel; Sanchez-Gonzalez, Jorge Manuel; Ramos-Remus, Cesar

    2016-09-01

    The aim of this study was to assess the changes in the characteristics of rheumatoid arthritis information on the Internet over a 15-year period and the positioning of Web sites posted by universities, hospitals, and medical associations. We replicated the methods of a 2001 study assessing rheumatoid arthritis information on the Internet using WebCrawler. All Web sites and pages were critically assessed for relevance, scope, authorship, type of publication, and financial objectives. Differences between studies were considered significant if 95 % confidence intervals did not overlap. Additionally, we added a Google search with assessments of the quality of content of web pages and of the Web sites posted by medical institutions. There were significant differences between the present study's WebCrawler search and the 2001-referent study. There were increases in information sites (82 vs 36 %) and rheumatoid arthritis-specific discussion pages (59 vs 8 %), and decreases in advertisements (2 vs 48 %) and alternative therapies (27 vs 45 %). The quality of content of web pages is still dispersed; just 37 % were rated as good. Among the first 300 hits, 30 (10 %) were posted by medical institutions, 17 of them in the USA. Regarding readability, 7 % of these 30 web pages required 6 years, 27 % required 7-9 years, 27 % required 10-12 years, and 40 % required 12 or more years of schooling. The Internet has evolved in the last 15 years. Medical institutions are also better positioned. However, there are still areas for improvement, such as the quality of the content, leadership of medical institutions, and readability of information.

  5. Introduction

    Directory of Open Access Journals (Sweden)

    Helge Hvid

    2013-01-01

    This issue includes six articles where we start off by Abrahamsson and Johansson, who give us a short but comprehensive presentation of how psychosocial work environment has been understood in research and policy over 100 years, with Sweden as the focal point. Short, because they write in the format of an article. Comprehensive, because the authors take a broad understanding of the psychosocial work environment comprising “health/illness,” where factors such as stress and burnout are central, “management and development,” where employee involvement, learning, and innovation are central, and “problematization,” which includes critically oriented research on the nature of work. The article not only provides an overview of the research that has been done in this area in the last 100 years but also relates research to policy and practice. The article thus provides a valuable perspective on today’s research and public debate on the works, with a Nordic perspective (...

  6. Introduction

    International Nuclear Information System (INIS)

    Nishiyama, A.

    1993-01-01

    In 1972, Nuclear Fuels Divisions of Sumitomo and Furukawa Electric Industries merged and became a subsidiary of Sumitomo and Furukawa Industries which is now called Nuclear Fuel Industries, Ltd. We design and manufacture various kinds of nuclear fuels. As for research reactor fuel, we began our development activities in 1956. Since then we have spent over 2 million dollars for development of nuclear fuels and plant facilities including complete manufacturing and testing capabilities. Now we are the only supplier of the research reactor fuel in Japan. Our fabrication process starts with the melting, alloying, and casting of U-Al. The uranium billets are prepared by foreign fabricators. The uranium content varies from 13 to 22 wt % according to the purchaser's specifications. In making fuel plates, the picture frame method is applied. In this case, our original procedure is sufficiently effective in avoiding dogboning. The plates are finished by hot and cold roll milling and inspected dimensionally, metallurgically, and mechanically, and at the same time the blister test and X-ray radiographic tests are performed. Fuel elements are assembled by rolling flat or curved plates into side plate grooves and end-fit welding. Finished elements are tested dimensionally and hydraulically. Nominal losses during operation are less than 1% of the uranium metal. Our present capacity licensed by the Japanese Government is approximately 950 fuel elements a year. About 35 employees including engineers are engaged in development and manufacturing of fuels. Owing to the small limited demand of the research reactor fuels in Japan during the past 20 years (mostly in last 10 years), we processed only about 350 kg of highly enriched uranium and supplied approximately 1000 fuel elements to JAERI, Kyoto University, and others, and we have been suffering red-ink balance of budget every year

  7. Introduction

    International Nuclear Information System (INIS)

    El-Hinnawi, E.E.

    1980-01-01

    The various components of the environment are described briefly, and the effect on these of the pollution or contamination arising from differing energy technologies (in particular from nuclear energy) is discussed. Several estimates of the growth of nuclear power by the year 2000 are tabulated. A summary is presented of the nuclear fuel cycle, including: types of reactors; the LWR fuel cycle; other fuel cycles. (U.K.)

  8. Introduction

    OpenAIRE

    2014-01-01

    Every year, an estimated 25,000 to 50,000 species go extinct on the Earth owing to changes caused by human activity. Many international organisations including the World Conservation Union (IUCN) consider biological invasions to be the second most important cause of biodiversity loss worldwide, coming just after habitat destruction. On small islands, where biodiversity is both exceptionally original and exceptionally vulnerable, it is the main cause of species extinction. The New Caledonian a...

  9. Introduction

    International Nuclear Information System (INIS)

    Rusek, K.

    2010-01-01

    Heavy Ion Laboratory (HIL) is a part of the University of Warsaw, the largest university in Poland. It is the largest experimental nuclear physics laboratory in the country, equipped with a K=160 cyclotron. The first beam was extracted in 1993 and since that time HIL is an effective '' user facility '', serving up to the present time over 350 scientists from Poland and abroad and becoming a recognised element of the European Research Area. The research programme comprises nuclear and atomic physics, materials science, radiochemistry, biology and particle detector development. HIL is currently in a transition period and will shortly become an accelerator centre, operating two cyclotrons. Installation of a commercial proton-deuteron cyclotron (E p = 16.5 MeV) is under way in the HIL building. This accelerator will be used for the production of and research on radiopharmaceuticals for the Positron Emission Tomography (PET). Production of long-lived radiopharmaceuticals for other medical and life-science applications is also foreseen. HIL is located at the University Ochota Campus, together with Faculties of Biology, Geology, Chemistry and Mathematics. In the next few years the Faculty of Physics will also move from its present location at Hoza Street to the Ochota Campus and we are hoping for a much closer collaboration between HIL and the Faculty of Physics in the future. The Ochota Campus is located close to the main campus of the Medical University and its clinic. This opened a possibility for a very close collaboration, established a few years ago, between HIL and the Department of Nuclear Medicine of the Medical University. An especially important achievement at HIL in 2009 was the commissioning of the EAGLE spectrometer in May, followed by the experimental campaign. EAGLE is an array of gamma-ray detectors designed as a multi-configuration detector setup adjustable to the needs of several research groups. In the present configuration it is equipped with 12 anti

  10. Introduction

    International Nuclear Information System (INIS)

    Jastrzebski, J.

    2004-01-01

    Full text: The year 2003 was a consecutive period of a regular activity of the Heavy Ion Laboratory. The Cyclotron was delivering the heavy ion beams ranging from 11 B to 40 Ar to ten different experiments during more than 2000 hours. A few teams were able to finalize their previous years data collection by papers published in high-ranked journals. Other teams published in the proceedings of the international conferences their invited talks or oral contributions. Thirteen publication in ISI listed journals appeared last year basing on the data obtained using Warsaw machine. A similar number was published by the Laboratory staff using external facilities. The modest technical upgrades presented in this Report were achieved almost with no cost above the salaries. The 15 % decrease of the previous years running subvention from the Ministry of Science and Informatics accompanied by a consecutive refusal to fund the new ECR ion source makes the status of the Laboratory as the nuclear physics center in a very precarious position. The situation looks much more promising with the new project: the creation of an interdisciplinary Laboratory - the Warsaw Positron Emission Tomography Centre, launched by the Heavy Ion Laboratory and the Nuclear Medicine Department at the Clinical Hospital of the Warsaw Academy of Medicine in 2001. In 2003 the Warsaw Consortium for PET Collaboration (WCPC) was created and presently it takes an active role in the project preparation. The WCPC will dispose of a single radiopharmaceuticals production unit located at HIL and equipped with a commercial proton/deuteron cyclotron, chemical units and quality control laboratory. The PET CT, PET or adapted SPECT scanners will be successively located in the Warsaw hospital centers, starting with the medical unit closest (500 m) to the radiopharmaceutical production place. The participation in the WCPC of numerous University and Academy of Sciences units will promote the Warsaw Centre activity in research

  11. Introduction

    Directory of Open Access Journals (Sweden)

    Renée Dickason

    2009-10-01

    Full Text Available It is fascinating to study history of propaganda in a British setting since it was a word which was used far less in Britain than in many other countries not least during the years leading up to the Second World War. […] Whether or not contemporaries in any generation used the word—and it is a word which itself demands detailed chronological charting— historians are compelled to use it. Sometimes its role is obvious, even crude, whether words or pictures are being employed. At other times its...

  12. The International Science and Technology Center (ISTC) - Fifteen-Year Experience in Management of Innovative Nuclear and Other Programs (Information Review)

    Energy Technology Data Exchange (ETDEWEB)

    Gudowski, W.; Tocheny, L.V. [ISTC - International Science and Technology Center, Krasnoproletarskaya 32-34, PO Box 20, 127473 Moscow (Russian Federation)

    2009-06-15

    Introduction: The ISTC is a unique international organization created in Moscow in 1994 by Russia, USA, EU and Japan. Later Korea and Canada, and several CIS countries as well acceded to ISTC. The basic idea behind establishing the ISTC was to support non-proliferation of the mass destruction weapons technologies by redirecting former Soviet weapons scientists to peaceful research thus preventing the drain of dangerous knowledge and expertise from Russia and other CIS countries. Presently, the ISTC now has 40 member countries (27 from EU), representing the CIS, Europe, Asia, and North America. The Partner list includes over 200 organizations and leading industrial companies from all ISTC parties. Numerous science and technology projects were realized with the ISTC support in different areas, from bio-technologies and environmental problems to all aspects of nuclear studies, including those focused on the development of effective innovative concepts and technologies in the nuclear field, in general, and for improvement of nuclear safety, in particular. Concept: Challenge of the World Nuclear Community is to prove to Public over the World, that newly proposed nuclear concepts are safe and effective. The only acceptable method, which is trusted and accepted by Public both now and always, is basic-type and demonstration-type Experiment, in advance of computer or paper-type arguing. Important that results of these experiments are to be available for international analysis and validation. Problems are that nuclear experiments are very complex, its require special licensing, long time preparation, appealing to high-skilled personnel, purchasing by nuclear and special materials and tools, as a result - raised budgeting. In this sense the ISTC clients (first of all - nuclear and 'nuclear weapon' institutes in Russia and CIS) have all set, ready, licensed, and equipped unique nuclear installations, high-skilled personnel, good cooperation. Essential, that the ISTC

  13. Introduction

    Science.gov (United States)

    Cheng, K. S.; Romero, Gustavo E.

    In the last 15 years, gamma-ray astronomy has evolved from a promis-ing but rather exotic branch of astronomical science to become a mature field of research with its own well-defined referents: cosmic gamma-ray sources. These sources include some of the most extraordinary objects known to human beings: pulsars, active galactic nuclei, accreting black holes, supernova remnants, and gamma-ray bursts. A significant com-ponent of our current knowledge of such objects is the direct result of astronomical measurements of the high-energy photons they produce. Satellite-borne instruments that can detect gamma-rays in the Earth's orbit or in deep space and atmospheric air shower detectors that re-construct the energy and direction of high-energy photons through the Cherenkov light generated in particle showers produced in the Earth's atmosphere have been the basic exploratory tools of gamma-ray astron-omy. For many years, however, cosmic gamma-ray sources defied all attempts at their detection.

  14. Introduction

    International Nuclear Information System (INIS)

    Rusek, K.

    2011-01-01

    This year was a year of hope for change. We attempted to become one of the laboratories of the '' Road Map of National Research Infrastructure '' of the Ministry of Science and Higher Education (MNiSW) of Poland. At the beginning of the year we were informed by the MNiSW that we had passed the first selection with the suggestion that we prepare, as the next step, a joint project with the H. Niewodniczanski Institute of Nuclear Physics of the Polish Academy of Science (IFJ) in Cracow. On the 21 st of April the Rector of the University of Warsaw and the director of IFJ created the consortium '' National Cyclotron Laboratory '', signing an agreement between our two institutions. In this way the two largest nuclear physics institutes in Poland, with two operating cyclotrons (a proton cyclotron in Cracow and the heavy-ion cyclotron in Warsaw) and two others becoming operational within the next two years, united their efforts and prepared a common project devoted to fundamental research in nuclear physics and its medical applications. Unfortunately, our project was not selected for the '' Road Map '' - a decision of the MNiSW incomprehensible to us. Since such a document must be regularly updated we will continue our efforts to find a place on the national '' Road Map ''. Despite our lack of success in our own country, on the European level our laboratory was recognised by the Nuclear Physics European Collaboration Committee (NuPECC). This important international body released in December the '' NuPECC Long Range Plan 2010, Perspectives of Nuclear Physics in Europe ''. Our laboratory is listed among other European small scale facilities with the recommendation - '' These national and other university based facilities are needed for specific experimental programmes, development and testing of new instruments and to provide education of next-generation researchers from university groups ''. It was not an easy year for experimentalists. In the spring the new Supernanogan

  15. Prevalence and contributing factors to attention deficit hyperactivity disorder: a study of five- to fifteen-year-old children in Zhabei District, Shanghai.

    Science.gov (United States)

    Jin, Wenlan; Du, Yasong; Zhong, Xiangyang; David, Coghill

    2014-12-01

    This work aims to understand the features among 5- to 15-year-old children with attention deficit hyperactivity disorder (ADHD) in Zhabei District in Shanghai. Children with ADHD were studied using general background questionnaire, ADHD symptom rating questionnaire, and cluster-stratified sampling. A total of 9,900 valid questionnaires were utilized in this study. We conducted diagnostic interviews with suspected ADHD children and their parents using the criteria of the Diagnostic and Statistical Manual of Mental Disorders (4th Edition) for ADHD. The prevalence rate of ADHD among the children was 4.6%, of which 2.4%, 0.4%, and 1.8% had ADHD-I ADHD-HI, and ADHD-C types, respectively. The prevalence rates in boys and girls were 6.6% and 2.7% (ratio, 2.41 : 1), respectively. Significant differences in prevalence rate were found among children with different age groups and ADHD types. Children aged 7-10 years had the highest prevalence rate (6.3%). Externally, residence children had higher prevalence than local residents. Significant differences in prevalence rate were also found among children with parents having different educational and socioeconomic level. The prevalence of ADHD-HI was higher than the other two types. The highest prevalence was observed in 7- to 10-year-old children. The influential factors of ADHD prevalence were age, gender, and educational level. © 2013 The Authors. Asia-Pacific Psychiatry published by Wiley Publishing Asia Pty Ltd.

  16. Introduction

    International Nuclear Information System (INIS)

    Jastrzebski, J.

    2007-01-01

    The Heavy Ion Laboratory of the Warsaw University is a 'User type' facility, providing heavy ion beams to a number of Polish and foreign research groups and, to limited extent, for its own research programme. In 2006 the Warsaw cyclotron has operated during about 2500 hours of beam on target. 18 experiments, all recommended by the Program Advisory Committee, have been performed by more than one hundred facility users. Their scientific achievements are presented in this Report. This year the publication harvest was slightly smaller as compared to previous years. However, the first Phys. Rev. Letters paper, based completely on the HIL data, should be noticed. The important part of the Laboratory team effort was devoted to educational and science popularization activities, described in details in the following pages of this report. Here, I would like to especially mention the Workshop on Heavy Ion Acceleration and its Application, devoted to physics students of Universities outside Warsaw. The 2006 Workshop was organized for the second time. We do hope, that this workshop will contribute to establishing in Poland more formal recognition for inter-university students and tutors exchange. This, as we hope, will benefit in the Ministry funding of this programme in the future. In 2006 the Laboratory equipment was further developed. The ICARE particle multidetector system was installed on the beam line D and was tested using 16 O beam. Work is in progress on improving its characteristics (signal processing and acquisition) and on expanding possible applications by adding the Time-of-Flight components. The project of a new gamma-ray spectrometer with up to 30 Ge detectors was prepared, discussed and preliminary accepted for realization, when necessary funds are available. In the mean time a new particle detector chamber was tested in coincidence with the OSIRIS II set-up, demonstrating a substantially higher efficiency and lower background in the Coulomb excited gamma

  17. Introduction

    Directory of Open Access Journals (Sweden)

    Svetlana Cojocaru

    2008-04-01

    Full Text Available It is more than 10 years since we have published our first special issue devoted to the Computer Algebra. For us it was a starting point for the development of Computer Algebra in Moldova. Looking back we can say that this was a period during which we have found our own place in this very important part of modern Computer Science. It was, of course, impossible without the help of our colleagues from other countries, without the financial support from INTAS and Swedish Academy of Science. In fact the most part of articles, published in this issue was supported by INTAS project Nr 05-104-7553 and we are very grateful for this important help.

  18. Introduction

    International Nuclear Information System (INIS)

    Edwards, D.A.

    1989-01-01

    The Tevatron project included the construction of three new synchrotrons, but common usage has attached that name to the superconducting ring. In the mid 70's the growing appreciation of the potential of hadron colliders added an additional function to the requirements for the superconducting ring. It should act as a storage ring as well. The main special design features of the superconducting accelerator are the magnets themselves and the cryogenics to cool them. But other systems are also required such as magnet power systems and vacuum systems. The Tevatron was commissioned in 1983. Over four years after its commissioning, the Tevatron is still very much a prototype accelerator, as much a research instrument in its own right as it is a high energy physics tool

  19. Introduction

    Directory of Open Access Journals (Sweden)

    Laura Guidi

    2016-03-01

    Full Text Available Ten years ago, a group of women, professors, senior and junior researchers, started La camera blu, the first gender studies review of the University of Naples Federico II. The War and the women’s involvement was decided to be the first topic to deal with. The choice was due to two main considerations: a the difference that crucial historical moments, wars and revolutions particularly, meant for men and women; b the conspicuous absence of women’s experience in literature and history accounts. The idea that war is “ men’s business, not ladies” was at the heart of it. In not a surprisingly way, new aspects were pointed out such as the split between national and private history, the complex way the cultural memory of a nation is developed, the separation between individual ideology and national ideology.

  20. Introduction

    Directory of Open Access Journals (Sweden)

    Helge Hvid

    2015-06-01

    Full Text Available In this issue we present six articles, which are quite different in both scope and methodology. Changes in the quality of working life are however a common interest in all articles. Two articles deal with the tension between passion and exploitation in current working life—one is a theoretical article, the other is primarily empirical. Two articles deal with the effects of flexibility on the quality of working life: one examined the effects of the ‘flexicurity model’ on the quality of working life; the other examined how the flexibility of work in elder care affects the quality of working life.  Another article examines the importance of personal relationship to the nearest leader for well-being. In the last article the position of women at the labor market is analyzed in the perspective of the last 50 years (...

  1. Introduction

    Directory of Open Access Journals (Sweden)

    Feltes Thomas

    2013-07-01

    Full Text Available The aim of the three-year European-wide research project “Gender-based Violence, Stalking and Fear of Crime” (2009-2011 was to verify this hypothesis and to collect, analyse and compare relevant data in five European countries. The EU project, which has been funded through the program “Prevention of and Fight against Crime” and initiated by the EU Commission on General Justice, Freedom and Security, was coordinated by the Department of Criminology at the Ruhr University Bochum in Germany. In addition, the consortium covers the University of Bologna, Jagiellonian University in Cracow/Poland, Universitát Autonoma de Barcelona/Spain and Keele University in the U.K.The victimisation of young women through sexual harassment, stalking and sexual violence, along with their fear of crime, and their need for support, were the subject of an online questionnaire made available at universities in Germany, Italy, Spain, Poland and Britain.

  2. Introduction

    DEFF Research Database (Denmark)

    Eamets, Raul; Humal, Katrin; Beblavý, Miroslav

    2017-01-01

    The balance of flexibility and security for labour market participants is a perennial challenge for policy-makers. In the late 1990s, the term ‘flexicurity’ seemed to offer a solution to this balancing act. Indeed, in the first decade of this century, ‘flexicurity’ became a dominant theme...... at the European and national level, and although its use has declined in recent years, the flexibility/security balance has remained a central factor in determining labour market outcomes – particularly for young people. However, the concept of ‘flexicurity’ received a lot of criticism, often related to a lack...... of clarity in its definition. On the one hand, this definitional ambiguity helps explain why the concept was picked up so easily at the policy level across a wide variety of stakeholders and national contexts. On the other hand, the ambiguity also explains how policies resulting in an overemphasis...

  3. Neck pain in a sample of Greek urban population (fifteen to sixty-five years): analysis according to personal and socioeconomic characteristics.

    Science.gov (United States)

    Stranjalis, George; Kalamatianos, Theodosis; Stavrinou, Lampis C; Tsamandouraki, Kiki; Alamanos, Yiannis

    2011-07-15

    A cross-sectional study of neck pain and its related aspects in a sample of Greek urban population (15-65 years). To estimate the prevalence of neck pain in a Greek urban population (15-65 years) and to study the association of neck pain with several socioeconomic and demographic characteristics. The results of several prevalence studies carried out in different populations indicate a high frequency of neck pain in the general population. Socioeconomic and demographic factors are likely to influence neck pain frequency and neck pain-associated burden. A 1000-person sample of the general Greek population (15-65 years) living in the Greek capital and other urban centers of the country was selected by multiple-stage sampling, with definition of sample quotas based on demographic characteristics. Data on neck pain and its related aspects, including healthcare utilization, as well as demographic, socioeconomic, and employment data, were collected through personal interviews. Of the 204 individuals who reported neck pain during the last month, 35 (17.2%) consulted a physician, 72 (35.3%) received medication, and 15 (7.4%) stayed in bed for some time, during this period and because of neck pain. The mean duration of pain for individuals who reported neck pain during the last month was 12 days. A total of 8.6% of working individuals who experienced neck pain during the last month reported work absenteeism due to this pain, during this period; the mean duration of absence was 4.6 days. Neck pain frequency was related to several sociodemographic factors. Female sex, increased age, and being married showed a statistically significant association with the presence of neck pain. The present results indicate that neck pain is a common symptom in the studied Greek urban population. Nevertheless, relatively few individuals seek medical advice for this symptom. Neck pain frequency is associated with age, sex, and marital status.

  4. Introduction

    Science.gov (United States)

    Cohen, E. G. D.

    deduced for irreversible processes (C. Jarzynski). The survey of non-equilibrium steady states in statistical mechanics of classical and quantum systems employs heat bath models and the random matrix theory input. The quantum heat bath analysis and derivation of fluctuation-dissipation theorems is performed by means of the influence functional technique adopted to solve quantum master equations (D. Kusnezov). Chapter II deals with an issue of relaxation and its dynamical theory in both classical and quantum contexts. Pollicott-Ruelle resonance background for the exponential decay scenario is discussed for irreversible processes of diffusion in the Lorentz gas and multibaker models (P. Gaspard). The Pollicott-Ruelle theory reappears as a major inspiration in the survey of the behaviour of ensembles of chaotic systems, with a focus on model systems for which no rigorous results concerning the exponential decay of correlations in time is available (S. Fishman). The observation, that non-equilibrium transport processes in simple classical chaotic systems can be described in terms of fractal structures developing in the system phase space, links their formation and properties with the entropy production in the course of diffusion processes displaying a low dimensional deterministic (chaotic) origin (J. R. Dorfman). Chapter III offers an introduction to the theory of dynamical semigroups. Asymptotic properties of Markov operators and Markov semigroups acting in the set of probability densities (statistical ensemble notion is implicit) are analyzed. Ergodicity, mixing, strong (complete) mixing and sweeping are discussed in the familiar setting of "noise, chaos and fractals" (R. Rudnicki). The next step comprises a passage to quantum dynamical semigroups and completely positive dynamical maps, with an ultimate goal to introduce a consistent framework for the analysis of irreversible phenomena in open quantum systems, where dissipation and decoherence are crucial concepts (R

  5. A year of mentoring in academic medicine: case report and qualitative analysis of fifteen hours of meetings between a junior and senior faculty member.

    Science.gov (United States)

    Rabatin, Joseph S; Lipkin, Mack; Rubin, Alan S; Schachter, Allison; Nathan, Michael; Kalet, Adina

    2004-05-01

    We describe a specific mentoring approach in an academic general internal medicine setting by audiotaping and transcribing all mentoring sessions in the year. In advance, the mentor recorded his model. During the year, the mentee kept a process journal. Qualitative analysis revealed development of an intimate relationship based on empathy, trust, and honesty. The mentor's model was explicitly intended to develop independence, initiative, improved thinking, skills, and self-reflection. The mentor's methods included extensive and varied use of questioning, active listening, standard setting, and frequent feedback. During the mentoring, the mentee evolved as a teacher, enhanced the creativity in his teaching, and matured as a person. Specific accomplishments included a national workshop on professional writing, an innovative approach to inpatient attending, a new teaching skills curriculum for a residency program, and this study. A mentoring model stressing safety, intimacy, honesty, setting of high standards, praxis, and detailed planning and feedback was associated with mentee excitement, personal and professional growth and development, concrete accomplishments, and a commitment to teaching.

  6. Introduction

    Science.gov (United States)

    de Graauw, T.

    2010-09-01

    As this editorial is written, we have seven antennas at the Chajnantor plateau, the "High Site". Seven antennas means twenty-one baselines, i.e. more than twice as many as we had only two months ago. As you know, the bonus we have in interferometry is that the the number of baselines increases roughly with the square of the available antennas. The image quality can be further enhanced, because the projection of a celestial source onto the existing baselines changes due to the rotation of the Earth. A large number of baselines is important but not sufficient to fulfill one important promise of ALMA, namely to provide crisp images. Unlike the sharp images from the Hubble Space Telescope, images from ground based optical or radio telescopes are blurred by the Earth's atmosphere. It is the Holy Grail of observing astronomy to overcome such atmospheric effects. Recently, ALMA has made a big step toward this goal by using Water Vapor Radiometers operating at 183 GHz to measure the amount of atmospheric water vapor at any instant in the line of sight of each antenna, and applying a corresponding correction to the astronomical data received. This not only improves the image quality, it is essential for using ALMA at its lowest wavelengths of around 0.3mm and at baselines exceeding several kilometers. Achieving this has a been a collaborative effort involving many parts of the project and there are all to be congratulated. JAO has now moved into our new Santiago Central Office in Vitacura next to the ESO premises, ending a phase of two years were Santiago based staff was distributed in two different buildings. This new ALMA office will also host the ALMA archive. Although ALMA users are normally not expected to come to Chile to observe, there will be office space for visitors, since ALMA has been and will always be a cooperation of people from many countries and many fields of science and engineering. This newsletter contains a list of workshops, schools and conferences

  7. Introduction

    Science.gov (United States)

    Narlikar, J. V.; Sathyaprakash, B. S.

    2014-03-01

    The ICGC Meetings: 1987-2011 When India became an independent nation in 1947, the presence of Jawaharlal Nehru on the scene, as the Prime Minister was a fortunate circumstance. For, Nehru was a visionary, who believed that the future of the new nation should be guided by science and technology (S & T), and so with like-minded scientists like, Shanti Swarup Bhatnagar, Homi Bhabha, Meghnad Saha, and Daulatsingh Kothari in leading positions, Nehru set about creating an extensive infrastructure for S & T. The initiatives taken in and around 1947 began to yield dividends in a couple of decades, and by the late 60s and early 70s, major S & T organizations and associated trained human resources were making significant contributions to the country's development, both material and intellectual. Amongst these may be included, the creation of various scientific societies devoted to specific subjects. These came in response to the urge of scientists to meet as a group for discussions in their fields of research. So, it was in 1969, a number of research workers in the field of general relativity and gravitation (GRG), who had gathered for a workshop in Ahmedabad, resolved to form a society for GRG. The initiative was taken by P C Vaidya, who pointed out the advantages of forming such a recognized group, mentioning that the international community of workers in GRG had already formed such a society. The Indian Association for General Relativity and Gravitation (IAGRG), thus, came up in 1969 with the veteran relativist V V Narlikar, as its first President. Some three years later, the astronomical community responding to a similar urge, formed the Astronomical Society of India (ASI), under the presidency of Vainu Bappu, the Founder Director of the Indian Institute of Astrophysics, Bangalore. Since the days of discovery of quasars in 1963, there has been an alliance between gravitation theorists and astrophysicists, resulting in the Texas Symposia, which are held once every two

  8. Introduction

    International Nuclear Information System (INIS)

    Jastrzebski, J.

    2006-01-01

    with our mechanical workshop, this detector is now awaiting to receive the first heavy ion beam and to pass the operation tests. Besides the heavy ion machine, the Laboratory will soon be equipped with the second, low energy (16.5 MeV, p), high current proton - deuteron cyclotron for the production of short lived radiopharmaceuticals for the Positron Emission Tomography. As already presented in the last year Annual Report, this will allow the creation of an interdisciplinary laboratory, the Warsaw Positron Emission Tomography Centre. This project was launched by the Heavy Ion Laboratory and the Nuclear Medicine Department at the Clinical Hospital of the Medical University in Warsaw in 2001. In 2003 the Warsaw Consortium for PET Collaboration (WCPC) was created and presently it plays an active role in the project preparation. The WCPC will possess a single radiopharmaceuticals production unit located at HIL and will be equipped with a commercial proton/deuteron cyclotron, chemical units and a quality control laboratory. The PET CT, PET or adapted SPECT scanners will be successively located in the Warsaw hospital centers, starting with the medical unit closest (500 m) to the radiopharmaceuticals production place. The participation in the WCPC of numerous University and Polish Academy of Sciences units will promote the Warsaw PET Centre activity in research and educational area. The planned purchase of the micro - PET animal scanner will substantially help in this activity. After four years of efforts, in 2004 the Warsaw PET project obtained the financial support from the Ministry of Sciences and Informatization, which allocated 10 MPLN (about 2.4 MEUR) for the equipment of the Radiopharmaceuticals Production Department of the Warsaw PET Centre. At the end of the same year the Board of Governors of the International Atomic Energy Agency accepted our project of Technical Cooperation with the Agency and allocated almost 0.9 MUS$ for this project. The same year, Ministry of

  9. Introduction

    Directory of Open Access Journals (Sweden)

    Javier González Díez

    2016-08-01

    Full Text Available This article starts from the remark that anthropology of religion and urban anthropology have been following different – and sometimes divergent – historical trajectories. Only in recent years the two perspectives started a dialogue and laid the foundations for a renewed study of religions in urban contexts. Against this background, the article claims the necessity for anthropological studies in which the approaches of anthropology of religion and of urban anthropology are put in contact. In order to answer to the problems that are at the basis of this special issue, we analyse the state of the art of the subject and describe the modalities and categories we propose for the study of religions in urban contexts and of the urban through the religious. Following this path, the article proposes that anthropology, due to its well established tradition of analysis both of religious and urban facts, is well positioned to propose new approaches and interpretative frames to keep together the religious dimension with other spheres in order to delineate an image of contemporary cities.

  10. Introduction

    Science.gov (United States)

    Warwick, Peter D.; Hook, Robert W.; SanFilipo, John R.; Warwick, Peter D.; Karlsen, Alexander K.; Merrill, Matthew D.; Valentine, Brett J.

    2011-01-01

    The National Coal Resource Assessment (NCRA) team of the U.S. Geological Survey (USGS) has assessed the quantity and quality of coal beds and zones that could be mined during the next 20 years or more. Geologic, geochemical, and resource information was collected and compiled for the five major coal-producing regions of the United States: the Appalachian Basin, Illinois Basin, Northern Rocky Mountains and Great Plains, Colorado Plateau, and the Gulf of Mexico Coastal Plain, (Gulf Coast) (Figure 1). In particular, the NCRA assessed coal-quality information and characterized environmentally significant trace elements, such as arsenic and mercury, that are defined in and administered by 1990 Clean Air Act Amendments (U.S. Environmental Protection Agency, 1990). The results of various USGS coal assessment efforts may be found at: http://energy.cr.usgs.gov/coal/coal_assessments/index.html, and a summary of the results from all assessment areas can be found in Ruppert et al. (2002) and Dennen (2009).

  11. Introduction

    Science.gov (United States)

    Crouch, Marshall F.

    In the history according to Luis Alvarez, the narrative starts with an exchange of remarks in the Berkeley cafeteria line. He quotes Fred to have asserted "I have thought how to do the most difficult experiment in physics. I'm going to be an experimentalist now." (He had been trained as a theorist.) "The only reason I would change from theory is if I could do the toughest experiment anybody knows about, namely, to sec the neutrinos coming out of a reactor. I know how to observe the neutrino plus proton reaction." Alvarez' response was "You are out of your mind. I thought about that several years ago. Absolutely impossible." Whereupon Fred went on, "I will tell you how to do it. Why don't we just take a big tank of liquid scintillator." "Oh my God, I've never thought of that," said Alvarez, for organic scintillators represented a new technique which for the first time would make it possible to envision really massive particle detectors…

  12. Peer-led training and assessment in basic life support for healthcare students: synthesis of literature review and fifteen years practical experience.

    Science.gov (United States)

    Harvey, P R; Higenbottam, C V; Owen, A; Hulme, J; Bion, J F

    2012-07-01

    In 1995, the University of Birmingham, UK, School of Medicine and Dentistry replaced lecture-based basic life support (BLS) teaching with a peer-led, practical programme. We present our 15-yr experience of peer-led healthcare undergraduate training and examination with a literature review. A literature review of healthcare undergraduate peer-led practical skills teaching was performed though Pubmed. The development of the Birmingham course is described, from its inception in 1995-2011. Training methods include peer-led training and assessment by senior students who complete an European Resuscitation Council-endorsed instructor course. Student assessors additionally undergo training in assessment and communication skills. The course has been developed by parallel research evaluation and peer-reviewed publication. Course administration is by an experienced student committee with senior clinician support. Anonymous feedback from the most recent courses and the current annual pass rates are reported. The literature review identified 369 publications of which 28 met our criteria for inclusion. Largely descriptive, these are highly positive about peer involvement in practical skills teaching using similar, albeit smaller, courses to that described below. Currently approximately 600 first year healthcare undergraduates complete the Birmingham course; participant numbers increase annually. Successful completion is mandatory for students to proceed to the second year of studies. First attempt pass rate is 86%, and close to 100% (565/566 students, 99.8%) following re-assessment the same day. 97% of participants enjoyed the course, 99% preferred peer-tutors to clinicians, 99% perceived teaching quality as "good" or "excellent", and felt they had sufficient practice. Course organisation was rated "good" or "excellent" by 91%. Each year 3-4 student projects have been published or presented internationally. The annual cost of providing the course is currently £15,594.70 (Eur 18

  13. The Effects of the Family Bereavement Program to Reduce Suicide Ideation and/or Attempts of Parentally Bereaved Children Six and Fifteen Years Later.

    Science.gov (United States)

    Sandler, Irwin; Tein, Jenn-Yun; Wolchik, Sharlene; Ayers, Tim S

    2016-04-01

    Findings concerning the long-term effects of the Family Bereavement Program (FBP) to reduce suicide ideation and/or attempts of parentally bereaved children and adolescents are presented. Parental death is a significant risk factor for suicide among offspring (Guldin et al., 2015). This study is a long-term follow-up of 244 children and adolescents who had participated in a randomized trial of the FBP, examining the intervention effects on suicide ideation and/or attempts as assessed through multiple sources. Results indicate a significant effect of the FBP to reduce suicide ideation and/or attempts at the 6- and 15-year follow-up evaluation. The findings support the potential benefits of further research on "upstream" suicide prevention. © 2016 The American Association of Suicidology.

  14. Roller Testing to Mimic Damage of the ISS SARJ Ring and Durability Test to Simulate Fifteen Years of SARJ Operation Using the Damaged Surface

    Science.gov (United States)

    Krantz, Timothy L.; Elchert, Justin P.; DellaCorte, Christopher; Dube, Michael J.

    2016-01-01

    The International Space Station's starboard Solar Alpha Rotary Joint (SARJ) experienced a breakdown of the joint's race ring surface. The starboard SARJ mechanism was cleaned and lubricated with grease. To provide some guidance on the expected behavior of the damaged SARJ ring with continued operations, experiments were conducted using rollers and a vacuum roller test rig. The approach of the experimental work involved three main steps: (1) initiate damage using conditions representative of the SARJ with inadequate lubrication; (2) propagate the damage by operating the test rollers without lubrication; and (3) assess the durability of the roller by testing to simulate the equivalent of 15 years of SARJ operation on the damaged surface assuming adequate grease lubrication. During the rig testing, additional and/or replacement grease was introduced at regular intervals to maintain good lubrication in the rig. The damage to the nitride layer continued even after application of grease. The grease lubrication proved to be effective for limiting the value of the axial force that can be developed. Limiting the axial force on the SARJ mechanism is important since the larger the axial force the more concentrated the load pressure becomes on the blend-radius location on the SARJ roller. After the testing simulating 15 years of SARJ operations, the wear depths were the order of 0.2 mm for the nitrided 15-5 roller and the order of 0.06 mm for the mating 440C roller. Metallographic inspections were done to search for indications of impending fatigue or other fracture indications that might eventually propagate and cause structural failure. There were no indications or features found that could eventually compromise structural integrity.

  15. Introduction

    Science.gov (United States)

    Arnold, Steven M.; Wong, Terry T.

    2011-01-01

    It would be hard to argue against the fact that Integrated Computational Materials Engineering (ICME) is a fast growing discipline within material science and engineering. A quick scan of the proceedings from conferences such as Aeromat, Material Science and Technology, and the TMS Annual Meeting clearly shows it. What began a few years ago as one symposium has grown into multiple ICME related symposia at each of these conferences. As encouraging as the number of symposia being offered is the attendance at the symposia. For example, one of the ICME symposia at MS&T 10, the symposium in which this book is based, had five sessions which culminated in a panel discussion that was standing room only. In addition to the large, annual materials science and engineering conferences, smaller 1 to 2-day conferences/workshops sponsored by government agencies (e.g. AFRL and NIST) on specific aspects of ICME and by universities promoting their ICME work are regularly offered. And arguably the most significant news with regards to ICME and conferences is the July 2011 First World Congress on ICME. This five day TMS sponsored conference, specifically focused on ICME with an international advisory board of ICME leaders, shows how far ICME has spread across the globe. Evidence for the growth of ICME can also be found in Academia. The University Materials Council (UMC) is composed of department heads for material science and engineering from major U.S. and Canadian universities. Meeting twice a year to share best practices in order to strengthen both the engineering content [1] and the educational process, the UMC s agenda for their Spring 2010 meeting was dedicated to ICME [2]. This meeting was held in response to the growing awareness that the universities play a major role in the success of ICME and therefore need to develop ICME curriculum in order to meet that need. To aid educators in the development of ICME courses, NSF is funding a "Summer School" on ICME to be held at the

  16. Introduction

    Directory of Open Access Journals (Sweden)

    Anne-Laure Van Bruaene

    2016-03-01

    Full Text Available After 450 years the Beeldenstorm of 1566 still deserves our careful historical analysis because it was unquestionably a game changer in Netherlandish politics and culture. More generally, we believe that iconoclasm breaks open cultural codes and thereby helps us to understand past societies. While we must thank the previous generations of historians for taking the iconoclasts seriously, the historians and art historians in this issue go a step further by also taking seriously the targets of iconoclasts – lay Catholic devotion and religious material culture. This theme number analyses the dialectics between iconoclasts and the material objectsthey targeted, between those who attacked and those who actively or passively defended the traditional community, between those who destroyed and those who restored or reinvented the religious patrimony, and in doing so reveals what was at stake in the sixteenth-century Low Countries.  Na 450 jaar verdient de Beeldenstorm van 1566 nog steeds een grondige historische analyse, aangezien er weinig twijfel kan bestaan over de enorme impact op de politiek en cultuur van de Nederlanden. Meer algemeen beschouwen wij iconoclasme als een kraker van culturele codes die ons helpt samenlevingen uit het verleden te begrijpen. Vorige generaties historici hebben zich vooral verdiept in de motieven van de iconoclasten, deze groep historici en kunsthistorici gaat verderdoor ook de doelwitten van de iconoclasten – de katholieke lekendevotie en de religieuze materiële cultuur – tot object van studie te maken. Dit themanummer ontrafelt de dialectiek tussen iconoclasten en de materiële cultuur die ze viseerden, tussen mannen en vrouwen die de traditionele gemeenschap aanvielen en deze die haar actief of passief verdedigden, tussen zij die het religieuze patrimonium vernielden en zij die het herstelden of herijkten. Op die manier wordt duidelijk waar het om draaide in de zestiende-eeuwse Nederlanden.

  17. Cerebral infarct in children aged zero to fifteen years Infarto cerebral em crianças de zero a quinze anos de idade

    Directory of Open Access Journals (Sweden)

    Thelma Ribeiro Noce

    2004-03-01

    Full Text Available Cerebral infarcts in children present peculiar characteristics either due to their diversity of causes or due to the unknown nature of the causes. The etiologies of cerebral infarct were reviewed in children from zero to 15 years old, attended at a tertiary hospital, in Ribeirão Preto (Brazil, from 1990 to 1997, adopting the modified Trial of ORG 10172 in Acute Stroke Treatment (TOAST criteria of classification; 1 - Atherosclerosis in large arteries; 2 - Cardioembolic; 3 - Occlusion of small vessels; 4 - Other etiologies; 5 - Undetermined cause. Thirty-nine children were included, 18 males and 21 females, aged 2 months to 15 years, mean age 5.67. The largest group, N=22 (56.4%, included children with ''other etiologies'', 7 of them aged under two years. The most common etiology was dehydration and septic shock leading to brain hypoperfusion and watershed infarcts. Nine (23% children had ''Undetermined etiology'', 7 (17,9% cardioembolic subtype and none had atherosclerosis. Laboratory improvement is needed for the large number of patients without a defined cause, and the high proportion of children with dehydration in the group with a determined cause emphasizes the need for preventive health actions among infants and children.Infartos cerebrais em crianças apresentam peculiaridades, como grande variedade de causas e alta freqüência sem etiologia definida. Foram revistos os diagnósticos etiológicos em crianças de zero a 15 anos, atendidas durante o ictus e com imagens cerebrais sugestivas de infarto, entre 1990 e 1997 em hospital terciário de Ribeirão Preto (SP. Adotou-se o critério de classificação modificado do Trial of ORG 10172 in Acute Stroke Treatment (TOAST: 1 - Arterioesclerose de grandes artérias, 2 - Cardioembólico, 3 - Oclusão de pequenos vasos, 4 - Outras etiologias, 5 - Não determinada. Trinta e nove crianças foram incluídas, 18 do sexo masculino e 21 do feminino, com idade variando entre 2 meses e 15 anos e m

  18. Scientists, engineers and technicians in nuclear reactor operation and maintenance. Fifteen years of growth and change in the United States of America

    International Nuclear Information System (INIS)

    Chewning, J.S.

    1980-01-01

    Between 1962 and 1977 the number of nuclear reactors in the United States of America increased from 4 to 65, and the total capacity increased from 730 to 47013 MW. Employment in the reactor operation and maintenance sector, which increased correspondingly from 633 to 17270, showed the earmarks of a maturing industry. By the end of that 15-year span, fewer workers were involved in research and development activities, and the proportion of scientists and engineers had decreased as the duties and responsibilities became more standardized and routine and could be taken over by highly trained technicians. There were also subtle changes in the discipline mixes. Nuclear and reactor engineers took their place in the labour force in increasing numbers as nuclear engineering was recognized as a distinct occupation, and there was a corresponding decrease in the proportion of more traditional engineering disciplines. Life science disciplines increased as concern grew for the health and safety of nuclear workers and the general public, and the physical science disciplines decreased in importance as proportionally less research and development was carried out in reactor operation and maintenance. A profile of nuclear power plant personnel drawn from refined data shows that the industry has truly 'come of age.' By far the largest group of workers is made up of technicians, with the second largest group made up of skilled craftworkers. Less than 30% of all workers in nuclear power operation and maintenance in 1977 were in professional occupations. (author)

  19. Fifteen Years (1993–2007 of Surface Freshwater Storage Variability in the Ganges-Brahmaputra River Basin Using Multi-Satellite Observations

    Directory of Open Access Journals (Sweden)

    Edward Salameh

    2017-03-01

    Full Text Available Surface water storage is a key component of the terrestrial hydrological and biogeochemical cycles that also plays a major role in water resources management. In this study, surface water storage (SWS variations are estimated at monthly time-scale over 15 years (1993–2007 using a hypsographic approach based on the combination of topographic information from Advance Spaceborne Thermal Emission and Reflection Radiometer (ASTER and Hydrological Modeling and Analysis Platform (HyMAP-based Global Digital Elevation Models (GDEM and the Global Inundation Extent Multi-Satellite (GIEMS product in the Ganges-Brahmaputra basin. The monthly variations of the surface water storage are in good accordance with precipitation from Global Precipitation Climatology Project (GPCP, river discharges at the outlet of the Ganges and the Brahmaputra, and terrestrial water storage (TWS from the Gravity Recovery And Climate Experiment (GRACE, with correlations higher than 0.85. Surface water storage presents a strong seasonal signal (~496 km3 estimated by GIEMS/ASTER and ~378 km3 by GIEMS/HyMAPs, representing ~51% and ~41% respectively of the total water storage signal and it exhibits a large inter-annual variability with strong negative anomalies during the drought-like conditions of 1994 or strong positive anomalies such as in 1998. This new dataset of SWS is a new, highly valuable source of information for hydrological and climate modeling studies of the Ganges-Brahmaputra river basin.

  20. [Introduction].

    Science.gov (United States)

    Gerard, Adrienne; van den Bogaard, Alberts

    2008-01-01

    Along with the international trends in history of computing, Dutch contributions over the past twenty years moved away from a focus on machinery to the broader scope of use of computers, appropriation of computing technologies in various traditions, labour relations and professionalisation issues, and, lately, software. It is only natural that an emerging field like computer science sets out to write its genealogy and canonise the important steps in its intellectual endeavour. It is fair to say that a historiography diverging from such "home" interest, started in 1987 with the work of Eda Kranakis--then active in The Netherlands--commissioned by the national bureau for technology assessment, and Gerard Alberts, turning a commemorative volume of the Mathematical Center into a history of the same institute. History of computing in The Netherlands made a major leap in the spring of 1994 when Dirk de Wit, Jan van den Ende and Ellen van Oost defended their dissertations, on the roads towards adoption of computing technology in banking, in science and engineering, and on the gender aspect in computing. Here, history of computing had already moved from machines to the use of computers. The three authors joined Gerard Alberts and Onno de Wit in preparing a volume on the rise of IT in The Netherlands, the sequel of which in now in preparation in a team lead by Adrienne van den Bogaard. Dutch research reflected the international attention for professionalisation issues (Ensmenger, Haigh) very early on in the dissertation by Ruud van Dael, Something to do with computers (2001) revealing how occupations dealing with computers typically escape the pattern of closure by professionalisation as expected by the, thus outdated, sociology of professions. History of computing not only takes use and users into consideration, but finally, as one may say, confronts the technological side of putting the machine to use, software, head on. The groundbreaking works of the 2000 Paderborn

  1. Trends of Mycobacterium bovis Isolation and First-Line Anti-tuberculosis Drug Susceptibility Profile: A Fifteen-Year Laboratory-Based Surveillance.

    Science.gov (United States)

    Bobadilla-del Valle, Miriam; Torres-González, Pedro; Cervera-Hernández, Miguel Enrique; Martínez-Gamboa, Areli; Crabtree-Ramirez, Brenda; Chávez-Mazari, Bárbara; Ortiz-Conchi, Narciso; Rodríguez-Cruz, Luis; Cervantes-Sánchez, Axel; Gudiño-Enríquez, Tomasa; Cinta-Severo, Carmen; Sifuentes-Osornio, José; Ponce de León, Alfredo

    2015-09-01

    Mycobacterium tuberculosis causes the majority of tuberculosis (TB) cases in humans; however, in developing countries, human TB caused by M. bovis may be frequent but undetected. Human TB caused by M. bovis is considered a zoonosis; transmission is mainly through consumption of unpasteurized dairy products, and it is less frequently attributed to animal-to-human or human-to-human contact. We describe the trends of M. bovis isolation from human samples and first-line drug susceptibility during a 15-year period in a referral laboratory located in a tertiary care hospital in Mexico City. Data on mycobacterial isolates from human clinical samples were retrieved from the laboratory's database for the 2000-2014 period. Susceptibility to first-line drugs: rifampin, isoniazid, streptomycin (STR) and ethambutol was determined. We identified 1,165 isolates, 73.7% were M. tuberculosis and 26.2%, M. bovis. Among pulmonary samples, 16.6% were M. bovis. The proportion of M. bovis isolates significantly increased from 7.8% in 2000 to 28.4% in 2014 (X(2)trend, ptuberculosis isolates (10.9% vs.3.4%, ptuberculosis, respectively (p = 0.637). A rising trend of primary STR monoresistance was observed for both species (3.4% in 2000-2004 vs. 7.6% in 2010-2014; p = 0.02). There is a high prevalence and a rising trend of M. bovis isolates in our region. The proportion of pulmonary M. bovis isolates is higher than in previous reports. Additionally, we report high rates of primary anti-tuberculosis resistance and secondary MDR in both M. tuberculosis and M. bovis. This is one of the largest reports on drug susceptibility of M. bovis from human samples and shows a significant proportion of first-line anti-tuberculosis drug resistance.

  2. Trends of Mycobacterium bovis Isolation and First-Line Anti-tuberculosis Drug Susceptibility Profile: A Fifteen-Year Laboratory-Based Surveillance

    Science.gov (United States)

    Bobadilla-del Valle, Miriam; Torres-González, Pedro; Cervera-Hernández, Miguel Enrique; Martínez-Gamboa, Areli; Crabtree-Ramirez, Brenda; Chávez-Mazari, Bárbara; Ortiz-Conchi, Narciso; Rodríguez-Cruz, Luis; Cervantes-Sánchez, Axel; Gudiño-Enríquez, Tomasa; Cinta-Severo, Carmen; Sifuentes-Osornio, José; Ponce de León, Alfredo

    2015-01-01

    Background Mycobacterium tuberculosis causes the majority of tuberculosis (TB) cases in humans; however, in developing countries, human TB caused by M. bovis may be frequent but undetected. Human TB caused by M. bovis is considered a zoonosis; transmission is mainly through consumption of unpasteurized dairy products, and it is less frequently attributed to animal-to-human or human-to-human contact. We describe the trends of M. bovis isolation from human samples and first-line drug susceptibility during a 15-year period in a referral laboratory located in a tertiary care hospital in Mexico City. Methodology/Principal Findings Data on mycobacterial isolates from human clinical samples were retrieved from the laboratory’s database for the 2000–2014 period. Susceptibility to first-line drugs: rifampin, isoniazid, streptomycin (STR) and ethambutol was determined. We identified 1,165 isolates, 73.7% were M. tuberculosis and 26.2%, M. bovis. Among pulmonary samples, 16.6% were M. bovis. The proportion of M. bovis isolates significantly increased from 7.8% in 2000 to 28.4% in 2014 (X 2 trend, ptuberculosis isolates (10.9% vs.3.4%, ptuberculosis, respectively (p = 0.637). A rising trend of primary STR monoresistance was observed for both species (3.4% in 2000–2004 vs. 7.6% in 2010–2014; p = 0.02). Conclusions/Significance There is a high prevalence and a rising trend of M. bovis isolates in our region. The proportion of pulmonary M. bovis isolates is higher than in previous reports. Additionally, we report high rates of primary anti-tuberculosis resistance and secondary MDR in both M. tuberculosis and M. bovis. This is one of the largest reports on drug susceptibility of M. bovis from human samples and shows a significant proportion of first-line anti-tuberculosis drug resistance. PMID:26421930

  3. The epidemiology and clinical spectrum of melioidosis in a teaching hospital in a North-Eastern state of Malaysia: a fifteen-year review.

    Science.gov (United States)

    Zueter, AbdelRahman; Yean, Chan Yean; Abumarzouq, Mahmoud; Rahman, Zaidah Abdul; Deris, Zakuan Z; Harun, Azian

    2016-07-16

    Over the last two decades, many epidemiological studies were performed to describe risks and clinical presentations of melioidosis in endemic countries. We performed a retrospective analysis of 158 confirmed cases of melioidosis collected from medical records from 2001 to 2015 in Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia, in order to update the current status of melioidosis clinical epidemiology in this putatively high risk region of the country. Principal presentations in patients were lung infection in 65 (41.1 %), skin infection in 44 (27.8 %), septic arthritis/osteomyelitis in 20 (12.7 %) and liver infection in 19 (12.0 %). Bacteremic melioidosis was seen in most of patients (n = 121, 76.6 %). Focal melioidosis was seen in 124 (78.5 %) of patients and multi-focal melioidosis was reported in 45 (28.5 %) cases. Melioidosis with no evident focus was in 34 (21.5 %) patients. Fifty-four (34.2 %) patients developed septic shock. Internal organ abscesses and secondary foci in lungs and/or soft tissue were common. A total of 67 (41 %) cases presented during the monsoonal wet season. Death due to melioidosis was reported in 52 (32.9 %) patients, while relapses were occurred in 11 (7.0 %). Twelve fatal melioidosis cases seen in this study were directly attributed to the absence of prompt acute-phase treatment. Predisposing risk factors were reported in most of patients (n = 133, 84.2 %) and included diabetes (74.7 %), immune disturbances (9.5 %), cancer (4.4 %) and chronic kidney disease (11.4 %). On multivariate analysis, the only independent predictors of mortality were the presence of at least one co-morbid factor (OR 3.0; 95 % CI 1.1-8.4), the happening of septic shock (OR 16.5; 95 % CI 6.1-44.9) and age > 40 years (OR 6.47; 95 % CI 1.7-23.8). Melioidosis should be recognized as an opportunistic nonfatal infection for healthy person. Prompt early diagnosis and appropriate antibiotics administration and

  4. Trends of Mycobacterium bovis Isolation and First-Line Anti-tuberculosis Drug Susceptibility Profile: A Fifteen-Year Laboratory-Based Surveillance.

    Directory of Open Access Journals (Sweden)

    Miriam Bobadilla-del Valle

    2015-09-01

    Full Text Available Mycobacterium tuberculosis causes the majority of tuberculosis (TB cases in humans; however, in developing countries, human TB caused by M. bovis may be frequent but undetected. Human TB caused by M. bovis is considered a zoonosis; transmission is mainly through consumption of unpasteurized dairy products, and it is less frequently attributed to animal-to-human or human-to-human contact. We describe the trends of M. bovis isolation from human samples and first-line drug susceptibility during a 15-year period in a referral laboratory located in a tertiary care hospital in Mexico City.Data on mycobacterial isolates from human clinical samples were retrieved from the laboratory's database for the 2000-2014 period. Susceptibility to first-line drugs: rifampin, isoniazid, streptomycin (STR and ethambutol was determined. We identified 1,165 isolates, 73.7% were M. tuberculosis and 26.2%, M. bovis. Among pulmonary samples, 16.6% were M. bovis. The proportion of M. bovis isolates significantly increased from 7.8% in 2000 to 28.4% in 2014 (X(2trend, p<0.001. Primary STR resistance was higher among M. bovis compared with M. tuberculosis isolates (10.9% vs.3.4%, p<0.001. Secondary multidrug resistance (MDR rates were 38.5% and 34.4% for M. bovis and M. tuberculosis, respectively (p = 0.637. A rising trend of primary STR monoresistance was observed for both species (3.4% in 2000-2004 vs. 7.6% in 2010-2014; p = 0.02.There is a high prevalence and a rising trend of M. bovis isolates in our region. The proportion of pulmonary M. bovis isolates is higher than in previous reports. Additionally, we report high rates of primary anti-tuberculosis resistance and secondary MDR in both M. tuberculosis and M. bovis. This is one of the largest reports on drug susceptibility of M. bovis from human samples and shows a significant proportion of first-line anti-tuberculosis drug resistance.

  5. Building Technologies Program Multi-Year Program Plan Technology Validation and Market Introduction 2008

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2008-01-01

    Building Technologies Program Multi-Year Program Plan 2008 for technology validation and market introduction, including ENERGY STAR, building energy codes, technology transfer application centers, commercial lighting initiative, EnergySmart Schools, EnergySmar

  6. Trend Spotting: NAFTA Disputes After Fifteen Years

    OpenAIRE

    Lawrence L. Herman

    2010-01-01

    Cross-border investment disputes have supplanted trade disputes as the main focus of legal actions under the North American Free Trade Agreement (NAFTA), according to this study. The author finds a growing number of these investment disputes entail challenges by American investors against Canada's provincial, as opposed to federal, laws and regulations. So important constitutional issues need clarifying between Ottawa and the provinces. He notes as party to the treaty, Ottawa must carry the b...

  7. BCES: A Fifteen-Year Conference Tradition

    Directory of Open Access Journals (Sweden)

    Nikolay Popov

    2017-05-01

    Full Text Available This volume contains selected papers submitted to the XV Annual International Conference of the Bulgarian Comparative Education Society (BCES, held in June 2017 in Borovets, Bulgaria, and papers submitted to the V International Partner Conference of the International Research Centre (IRC ‘Scientific cooperation’, Rostov-on-Don, Russia, organized as part of the BCES Conference. The XV BCES Conference theme is Current Business and Economics Driven Discourse and Education: Perspectives from Around the World. The V International Partner Conference theme is Science and Education in Modern Social, Economic and Humanitarian Discourse. The book consists of 38 papers written by 69 authors. The volume starts with an introductory paper by Johannes L van der Walt. The other 37 papers are divided into 8 parts: 1 Comparative Education & History of Education; 2 Teacher Education; 3 Education Policy, Reforms & School Leadership; 4 Higher Education, Lifelong Learning & Social Inclusion; 5 Law and Education; 6 Research Education; 7 Educational Development Strategies in Different Countries and Regions of the World; 8 Key Directions and Characteristics of Research Organization in the Contemporary World.

  8. Fifteen years experience: Egyptian metabolic lab

    African Journals Online (AJOL)

    Ekram M. Fateen

    2014-08-20

    Aug 20, 2014 ... defective enzymes or transport proteins which results in a block of the metabolic pathway and accumulation ... The detection of metabolic disorder is done ..... [42] Wood TC, Harvey K, Beck M, Burin MG, Chien YH, Church HJ,.

  9. The introduction of the 5-year impact factor : does it benefit statistics journals?

    NARCIS (Netherlands)

    van Nierop, Erjen

    In this paper, we investigate the effects of the introduction of 5-year impact factors. We collect impact factor data for all disciplines available in the Journal Citation Reports. For all these categories, we give insights into the relationship between the traditional 2-year impact factor and the

  10. Invasion and Colonisation of a Tropical Stream by an Exotic Loricariid Fish: Indices of Gradual Displacement of the Native Common Pleco (Hypostomus punctatus) by the Red Fin Dwarf Pleco (Parotocinclus maculicauda) over Fifteen Years.

    Science.gov (United States)

    Mazzoni, Rosana; Costa da Silva, Raquel; Pinto, Míriam Plaza

    2015-01-01

    The introduction of invasive species represents a major threat to the integrity of stream-dwelling fish populations worldwide, and this issue is receiving increasing attention from scientists, in particular because of potential impact on biodiversity. In this study, we analysed the dispersal of an exotic loricariid fish the red fin dwarf pleco (Parotocinclus maculicauda) in a stream of the Atlantic Forest biome in coastal south-eastern Brazil and evaluated the effects of this invasion on the native loricariid common pleco (Hypostomus punctatus). Specimens were collected at eight sites located along the course of the stream over a 15-year period. The distribution and density of the two species were determined by the Successive Removal Method. The introduction of P. maculicauda occurred in the medium sector of the stream, and during the course of the study, the species dispersed to new sites further upstream. By the end of the study, it was found at all points upstream from the original site. Hypostomus punctatus was registered at all sample sites both before and after the introduction of P. maculicauda, but its density decreased at all upstream sites after the arrival of the exotic species. Our analysis shows that colonisation by P. maculicauda seems to have a negative effect on H. punctatus densities. The maintenance of H. punctatus densities at the sites not colonised by P. maculicauda reinforces the conclusion that the colonisation of the stream by the exotic species had deleterious effects on the density of the resident H. punctatus populations, either by direct or indirect action.

  11. Invasion and Colonisation of a Tropical Stream by an Exotic Loricariid Fish: Indices of Gradual Displacement of the Native Common Pleco (Hypostomus punctatus by the Red Fin Dwarf Pleco (Parotocinclus maculicauda over Fifteen Years.

    Directory of Open Access Journals (Sweden)

    Rosana Mazzoni

    Full Text Available The introduction of invasive species represents a major threat to the integrity of stream-dwelling fish populations worldwide, and this issue is receiving increasing attention from scientists, in particular because of potential impact on biodiversity. In this study, we analysed the dispersal of an exotic loricariid fish the red fin dwarf pleco (Parotocinclus maculicauda in a stream of the Atlantic Forest biome in coastal south-eastern Brazil and evaluated the effects of this invasion on the native loricariid common pleco (Hypostomus punctatus. Specimens were collected at eight sites located along the course of the stream over a 15-year period. The distribution and density of the two species were determined by the Successive Removal Method. The introduction of P. maculicauda occurred in the medium sector of the stream, and during the course of the study, the species dispersed to new sites further upstream. By the end of the study, it was found at all points upstream from the original site. Hypostomus punctatus was registered at all sample sites both before and after the introduction of P. maculicauda, but its density decreased at all upstream sites after the arrival of the exotic species. Our analysis shows that colonisation by P. maculicauda seems to have a negative effect on H. punctatus densities. The maintenance of H. punctatus densities at the sites not colonised by P. maculicauda reinforces the conclusion that the colonisation of the stream by the exotic species had deleterious effects on the density of the resident H. punctatus populations, either by direct or indirect action.

  12. Tropical fish community does not recover 45 years after predator introduction.

    Science.gov (United States)

    Sharpe, D M T; De León, L F; González, R; Torchin, M E

    2017-02-01

    Predation is considered to be an important factor structuring natural communities. However, it is often difficult to determine how it may influence long-term, broad-scale, diversity patterns, particularly in diverse tropical systems. Biological introductions can provide powerful insight to test the sustained consequences of predation in natural communities, if pre-introduction data are available. Half a century ago, Zaret and Paine demonstrated strong and immediate community-level effects following the introduction of a novel apex predator (peacock bass, Cichla monoculus) into Lake Gatun, Panama. To test for long-term changes associated with this predator introduction, we followed up on their classic study by replicating historical sampling methods and examining changes in the littoral fish community at two sites in Lake Gatun 45 years post-introduction. To broaden our inference, we complemented this temporal comparison with a spatial analysis, wherein we compared the fish communities from two lakes with and one lake without peacock bass. Comparisons with historical data revealed that the peacock bass remains the most abundant predator in Lake Gatun. Furthermore, the collapse of the littoral prey community observed immediately following the invasion has been sustained over the past 45 years. The mean abundance of native littoral fish is now 96% lower than it was prior to the introduction. Diversity (rarefied species richness) declined by 64% post-introduction, and some native species appear to have been locally extirpated. We observed a similar pattern across invaded and uninvaded lakes: the mean abundance of native fishes was 5-40 times lower in lakes with (Gatun, Alajuela) relative to the lake without peacock bass (Bayano). In particular, small-bodied native fishes (Characidae, Peociliidae), which are common prey of the peacock bass, were more than two orders of magnitude (307 times) less abundant in Gatun and one order of magnitude (28 times) less abundant in

  13. Hanseníase em menores de quinze anos no município de Paracatu, MG (1994 a 2001 Leprosy in patients under fifteen years of age in the city of Paracatu-MG (1994 to 2001

    Directory of Open Access Journals (Sweden)

    Isaias Nery Ferreira

    2005-03-01

    actions due to the high rates of detection and prevalence of the condition, especially among children under fifteen years of age. In 1998 and 1999, an information program was implemented in order to provide explanations on the signs and symptoms of the disease to a population of 8,000 students, in order to improve the detection rate of the disease in children under fifteen years of age, given Paracatu was classified as a hyper-endemic city between 1997 and 2001. A descriptive study was carried out comprising forty-five patients diagnosed and treated in Paracatu between 1994 and 2001. Fifty-three percent of diagnoses were in male children, 75.5% of the cases being between ten and fourteen years of age; individuals had less years of schooling than what would be expected for their ages; 84% of the population lived in the urban area. All patients included (100% were new cases, of which 56% were multibacillary forms, mainly the Dimorph clinical form (potentially infectious, followed by the Undetermined (30.8% and Tuberculoid (13.2% forms. All were treated according to standard procedures, with a 100% cure rate. During treatment 24% of patients presented reactions, and 9% did after being discharged. Twenty-two percent of patients were diagnosed with some degree of disability, and 13% presented some degree of disability upon discharge (a rate considered high. Sixty-two percent of patients had contact with other Hansen's disease bearers, and only 15.5% of these contacts had two BCG vaccine scars. Leprosy is a serious public health problem in the city studied, and the work accomplished with students was primary to increase case detection.

  14. Fifteen chord FIR polarimetry system on MTX

    International Nuclear Information System (INIS)

    Rice, B.W.

    1992-03-01

    A far-infrared (FIR) polarimeter diagnostic has been added to an existing fifteen chord interferometer on the Microwave Tokamak Experiment (MTX). The polarimeter utilizes a new technique for determination of the Faraday rotation angle based on phase measurements of a rotating polarization ellipse. This technique allows the rotation angle to be determined even in the presence of signal amplitude variations caused by refraction. The implementation of this instrument requires no new detectors and minimal optics, making it quite inexpensive to add on to existing multichord interferometers. The MTX polarimeter has been operating for about a year and has achieved a resolution of ≤0.2 degrees with a bandwidth of ≅1 kHz and a chord spacing of 1.5 cm. Typical Faraday rotation angles on MTX are in the range of 5--15 degrees. To obtain the poloidal field, the line-integrated density and Faraday rotation profiles are inverted in a manner consistent with the Grad-Shafranov equilibrium to first order in the inverse aspect-ratio expansion. Profile measurements during normal ohmic operation are presented

  15. Introduction to the focus issue: fifty years of chaos: applied and theoretical.

    Science.gov (United States)

    Hikihara, Takashi; Holmes, Philip; Kambe, Tsutomu; Rega, Giuseppe

    2012-12-01

    The discovery of deterministic chaos in the late nineteenth century, its subsequent study, and the development of mathematical and computational methods for its analysis have substantially influenced the sciences. Chaos is, however, only one phenomenon in the larger area of dynamical systems theory. This Focus Issue collects 13 papers, from authors and research groups representing the mathematical, physical, and biological sciences, that were presented at a symposium held at Kyoto University from November 28 to December 2, 2011. The symposium, sponsored by the International Union of Theoretical and Applied Mechanics, was called 50 Years of Chaos: Applied and Theoretical. Following some historical remarks to provide a background for the last 50 years, and for chaos, this Introduction surveys the papers and identifies some common themes that appear in them and in the theory of dynamical systems.

  16. Diversion and injection of buprenorphine-naloxone film two years post-introduction in Australia.

    Science.gov (United States)

    Larance, Briony; Mattick, Richard; Ali, Robert; Lintzeris, Nicholas; Jenkinson, Rebecca; White, Nancy; Kihas, Ivana; Cassidy, Rosemary; Degenhardt, Louisa

    2016-01-01

    We report 2 years of post-marketing surveillance of the diversion and injection of buprenorphine-naloxone (BNX) film following its introduction in 2011. Interviews were conducted with people who inject drugs regularly (PWID) (2004-2013), opioid substitution therapy clients (2013, n = 492) and key experts (n = 44). Key outcomes were unsanctioned removal of supervised doses, diversion, injection and street price. Prevalence of past 6-month injection among PWID was adjusted for background availability of opioid substitution therapy medications using sales data. Among out-of-treatment PWID, the levels of regular (weekly+) BNX film injection were comparable to methadone and BNX tablets, and lower than mono-buprenorphine, adjusting for background availability. Fewer BNX film clients [3%; 95% (CI) 1-5] regularly injected their medication than mono-buprenorphine clients (25%; 95% CI 11-39), but at levels equivalent to those among methadone (3%; 95% CI 1-6) and BNX tablet clients (2%; 95% CI 0-6). Key experts perceived BNX film needed less supervised dosing time as it dissolved rapidly and was harder to remove from the mouth than sublingual tablets; however, removal of supervised doses was higher among BNX film clients (15%; 95% CI: 10-20) than methadone clients (3%; 95% CI 1-6), and not significantly different from BNX tablet (11%; 95% CI 2-21) and mono-buprenorphine clients (31%; 95% CI 16-46). Two years post-introduction, levels of BNX film diversion and injection remained comparable with those for methadone and BNX tablets, and lower than mono-buprenorphine. We found no evidence that BNX film has lower non-adherence and diversion than the tablet formulation. [Larance B, Mattick R, Ali R, Lintzeris N, Jenkinson R, White N, Kihas I, Cassidy R, Degenhardt L. Diversion and injection of buprenorphine-naloxone film two years post-introduction in Australia. Drug Alcohol Rev 2015]. © 2015 Australasian Professional Society on Alcohol and other Drugs.

  17. [Myxomatosis in the sub-antarctic islands of Kerguelen, without vectors, thirty years after its introduction].

    Science.gov (United States)

    Chapuis, J L; Chantal, J; Bijlenga, G

    1994-02-01

    Myxoma virus was introduced into the Kerguelen archipelago in 1955-1956. Thirty years after its introduction, the virus is present in most areas inhabited by rabbits. Rabbit fleas and mosquitoes are absent from this group of islands and the disease is transmitted by contact. The timing of the beginning of new myxomatosis outbreaks, the absence of real epizootics as well as the higher percentage of infected males over females are specific observations in favour of this mode of transmission. The majority of 34 isolates tested between 1984 and 1988 are of intermediate virulence (Grades IIIA-IIIB). In these conditions, the impact of myxomatosis virus on rabbit populations estimated on two sites is low. Myxomatosis therefore plays only a minor role in the regulation of rabbit populations.

  18. Introduction of microsurgery in Vietnam by a charitable organization: a 15-year experience.

    Science.gov (United States)

    Merrell, J Craig; Tien, Nguyen Viet; Son, Nguyen Tai; An, Luu Ngoc; Sellers, Daniel; Russell, Robert; Manktelow, Ralph; Wei, Fu-Chan; Orgill, Dennis P

    2007-04-01

    Microsurgical procedures, although equipment- and labor-intensive, allow efficient treatment of selected soft-tissue, bone, and peripheral nerve defects. The precise surgical skills required and the high equipment and institutional costs have been deterrents to initiating programs in developing countries. The authors report their 15-year international effort in facilitating the development of microsurgical techniques in Vietnam. The authors reviewed their educational, logistical, and operative experience from 11 Operation Smile International missions to Vietnam and the microsurgical procedures performed independently by Vietnamese surgeons at the Central Military Hospital 108 in Hanoi. Over 15 years, Operation Smile International missions to Vietnam performed 108 free tissue transfer operations with 15 peripheral nerve transfer procedures and 143 nonmicrosurgical reconstructive operations. Visiting surgeons with specialized expertise taught facial reanimation, flap prefabrication, and perforator flaps. During this same period, Vietnamese surgeons became facile with microsurgical techniques and independently performed a wide array of these procedures in the institutions visited. Vietnamese surgeons have organized microsurgery divisions within some hospital departments and now teach microsurgical techniques. Repeated missions allowed for patient follow-up, staged procedures, educational exchange, and quality control. Several Vietnamese surgeons have traveled abroad to obtain additional training and have set up training programs in other areas of Vietnam. Charitable organizations can help surgeons in developing countries master complex microsurgical techniques through short-term medical missions, donation of equipment and supplies, and the encouragement of institutional support. A continuing education program, including local conferences, microsurgical laboratory training facilities, and study abroad, can aid this introduction.

  19. Introduction of organised mammography screening in tyrol: results of a one-year pilot phase

    Directory of Open Access Journals (Sweden)

    Daniaux Martin

    2011-02-01

    additional resources. One year after introduction of the screening program, most of the quality indicators recommended by the European guidelines had been reached. However, it will be necessary to introduce double reading, to change the rule for BI-RADS 3, and to concentrate on actions toward improving the participation rate.

  20. Association between timing of food introduction in on first year old and the prevalence of allergies

    Directory of Open Access Journals (Sweden)

    Ismael San Mauro-Martín

    2014-09-01

    Full Text Available Introduction: Food allergy is an abnormal response after ingestion of an allergen in a food where there is a proven immune mechanism. During the period of breastfeeding, infants are introducing new foods in small quantities and separately for possible allergies. All in relation to the suggested timetable for the introduction of different food groups suggested by the Spanish Agency for Food Safety and Nutrition. Our project focused on studying the possible relationship between the variability of introduction of the different food groups and the development of allergies in infant.Material and Methods: Retrospective descriptive study in an incidental sample (n = 30. It evolved into an online platform with an Ad Hoc survey, in which data was recollected on the characteristics of allergy, diet, type of birth, and introduction of food were collected.Results: Allergies were found 36% fruit, 20% egg, nuts and dairy 16% and 12%, grains, legumes, seafood and vegetables 4% respectively. 89% were breastfeeding. 78% were born vaginally. 46.2% compliance with the protocol introduction and 53.8% advance or postpone the introduction.Conclusions: The data reviewed suggest that food allergies are influenced by several factors that can influence and affect the number of allergic conditions of a particular region, so it is necessary to define these variables in studies to have greater reliability in the necessary studies performed.

  1. Introduction of inappropriate complementary feeding in the first year of life and associated factors in children with low socioeconomic status.

    Science.gov (United States)

    Dallazen, Camila; Silva, Sara Araújo da; Gonçalves, Vivian Siqueira Santos; Nilson, Eduardo Augusto Fernandes; Crispim, Sandra Patricia; Lang, Regina Maria Ferreira; Moreira, Júlia Dubois; Tietzmann, Daniela Cardoso; Vítolo, Márcia Regina

    2018-02-19

    The study aimed to identify factors associated with the introduction of inappropriate complementary feeding in the first year of life in children living in municipalities (counties) with low socioeconomic statusl. This was a cross-sectional multicenter study in 1,567 children 12 to 59 months of age in 48 municipalities participating in the Brazil Without Poverty plan in the South of Brazil. A structured questionnaire was applied to the children's parents to obtain socio-demographic information and the age at which inappropriate complementary foods were introduced for the first time in complementary feeding. Prevalence of introduction of sugar before four months of age was 35.5% (n = 497; 95%CI: 33.1-38.0). The prevalence rates for the introduction of cookies/crackers, creamy yogurt, and jelly before six months of age were 20.4% (n = 287; 95%CI: 18.3-22.3), 24.8% (n = 349; 95%CI: 22.4-27.1), and 13.8% (n = 192; 95%CI: 12.0-15.7), respectively. Associations were identified between low maternal schooling (PR = 1.25; 95%CI: 1.03-1.51) and low monthly family income (PR = 1.22; CI95%: 1.01-1.48) and the introduction of inappropriate complementary feeding. The study identified the introduction of inappropriate complementary feeding in the first year of life among children in municipalities with high socioeconomic vulnerability in the South of Brazil, associated with low maternal schooling and low monthly family income.

  2. Reflecting on 25 Years of Teaching, Researching, and Textbook Writing for Introduction to Management: An Essay with Some Lessons Learned

    Science.gov (United States)

    Dyck, Bruno

    2017-01-01

    This essay describes innovations made and lessons learned while teaching introduction to management courses during a 25-year career. The essay describes how teaching two approaches to management increases students' critical and ethical thinking, and reverses the tendency for business students to become increasingly materialistic and…

  3. Femoral Component Revision with Use of Impaction Bone-Grafting and a Cemented Polished Stem: A Concise Follow-up, at Fifteen to Twenty Years, of a Previous Report*

    NARCIS (Netherlands)

    Te Stroet, M.A.; Gardeniers, J.W.M.; Verdonschot, N.J.; Rijnen, W.H.C.; Slooff, T.J.J.H.; Schreurs, B.W.

    2012-01-01

    We previously reported our results for thirty-three consecutive femoral component revisions with impaction bone-grafting, performed with the X-change femoral revision system and a cemented polished Exeter stem, at a minimum of eight years of follow-up. The present updated study shows the results

  4. Design, implementation and evaluation of a community health training program in an integrated problem-based medical curriculum: a fifteen-year experience at the University of Geneva Faculty of Medicine

    Directory of Open Access Journals (Sweden)

    Philippe Chastonay

    2012-06-01

    Full Text Available Background: In the literature the need for relevance in medical education and training has been stressed. In the last 40 years medical schools have been challenged to train doctors competent to respond to community health needs. In the mid-90s the University of Geneva Faculty of Medicine introduced an integrated medical curriculum. In this initiative a particular emphasis was put in introducing a 6-year longitudinal and multidisciplinary Community Health Program (CHP. Objectives: The aims of the present article are to describe the conception, elaboration and implementation of the CHP as well as its evolution over 15 years and the evaluation of its outcomes. Methods: The CHP was at its origin elaborated by a small group of highly motivated teachers and later on developed by a multi-disciplinary group of primary care physicians, epidemiologists, public health and bio-ethics specialists, occupational health professionals, lawyers and historians. Evaluation of the program outcomes included educational innovations, new developments of the curriculum and interactions between students and the community. Results: The CHP learning objectives and teaching modalities were defined by the multi-disciplinary group in consensus meetings which triggered a collaborative spirit among teachers and facilitated further developments. The evaluation procedures allowed the monitoring of students’ satisfaction which remained high over the years, students’ active participation which decreased over time and success at certifying exams which was globally as good as in basic life sciences. The evaluation also assessed outcomes such as educational innovations, new developments of the curriculum and interactions between students and the community. Conclusion: As suggested in the literature, our experience shows that the students’ direct exposure and practice in the community health environment is an effective training approach to broaden students’ education by

  5. Fifteen-year results of a randomized prospective trial of hyperfractionated chest wall irradiation versus once-daily chest wall irradiation after chemotherapy and mastectomy for patients with locally advanced noninflammatory breast cancer

    International Nuclear Information System (INIS)

    Buchholz, Thomas A.; Strom, Eric A.; Oswald, Mary Jane; Perkins, George H.; Oh, Julia; Domain, Delora; Yu, Tse-Kuan; Woodward, Wendy A.; Tereffe, Welela; Singletary, S. Eva; Thomas, Eva; Buzdar, Aman U.; Hortobagyi, Gabriel N.; McNeese, Marsha D.

    2006-01-01

    Purpose: To analyze the results of a Phase III clinical trial that investigated whether a hyperfractionated radiotherapy (RT) schedule could reduce the risk of locoregional recurrence in patients with locally advanced breast cancer treated with chemotherapy and mastectomy. Methods and Materials: Between 1985 and 1989, 200 patients with clinical Stage III noninflammatory breast cancer were enrolled in a prospective study investigating neoadjuvant and adjuvant chemotherapy. Of the 179 patients treated with mastectomy after neoadjuvant chemotherapy, 108 participated in a randomized component of the trial that compared a dose-escalated, hyperfractionated (twice-daily, b.i.d.) chest wall RT schedule (72 Gy in 1.2-Gy b.i.d. fractions) with a once-daily (q.d.) schedule (60 Gy in 2-Gy q.d. fractions). In both arms of the study, the supraclavicular fossa and axillary apex were treated once daily to 50 Gy. The median follow-up period was 15 years. Results: The 15-year actuarial locoregional recurrence rate was 7% for the q.d. arm and 12% for the b.i.d. arm (p = 0.36). The rates of severe acute toxicity were similar (4% for q.d. vs. 5% for b.i.d.), but moist desquamation developed in 42% of patients in the b.i.d. arm compared with 28% of the patients in the q.d. arm (p = 0.16). The 15-year actuarial rate of severe late RT complications did not differ between the two arms (6% for q.d. vs. 11% for b.i.d., p = 0.54). Conclusion: Although the sample size of this study was small, we found no evidence that this hyperfractionation schedule of postmastectomy RT offered a clinical advantage. Therefore, we have concluded that it should not be further studied in this cohort of patients

  6. Fish introductions in the former Soviet Union: The Sevan trout (Salmo ischchan - 80 years later.

    Directory of Open Access Journals (Sweden)

    Wiesław Bogdanowicz

    Full Text Available The Soviet Union played the leading role in fish introductions in Eurasia. However, only 3% of all introductions prior to 1978 gave a commercial benefit. One of the noteworthy examples appears to be the Sevan trout (Salmo ischchan Kessler, 1877-an endemic salmonid of Lake Sevan in Armenia. This species has been introduced to Kirghizstan, Kazakhstan, and Uzbekistan, however, only the Kirghiz population has persisted in relatively high numbers. In this paper we provide the first extensive molecular study of S. ischchan using samples from the native population from Lake Sevan and three hatcheries in Armenia, as well as from the population introduced to Lake Issyk Kul in Kirghizstan. The Kirghiz population has been isolated since the introductions took place in 1930 and 1936. Our results, based on 11 nuclear microsatellites and a 905 bp fragment of the mitochondrial control region suggest that hatcheries have maintained genetic variability by way of ongoing translocations of individuals from Lake Sevan. Simultaneously, significant Garza-Williamson M-values suggest that bottlenecks could have reduced the genetic variability of the wild populations in the past. This hypothesis is supported by historical data, indicating highly manipulated water-level regulations and poaching as two main factors that dramatically impact fish abundance in the lake. On the other hand, a similar situation has been observed in Kirghizstan, but this population likely rebounded from small population size faster than the other populations examined. The Kirghiz population is significantly genetically differentiated from the other groups and have morphological features and biological attributes not observed in the source population. Genetic data imply that the effective population size in the native population is lower than that found in the introduced population, suggesting that some active protection of the Lake Sevan population may be needed urgently.

  7. Implementing CBM: SQL-Tutor after Fifteen Years

    Science.gov (United States)

    Mitrovic, Antonija; Ohlsson, Stellan

    2016-01-01

    SQL-Tutor is the first constraint-based tutor. The initial conference papers about the system were published in 1998 (Mitrovic 1998a, 1998b, 1998c), with an "IJAIED" paper published in 1999 (Mitrovic and Ohlsson, "International Journal Artificial Intelligence in Education," 10(3-4), 238-256, 1999). We published another…

  8. A fifteen year experience of total thyroidectomy for the management ...

    African Journals Online (AJOL)

    Tracheostomy was required in 35 (5.8%) patients but none was permanent. Conclusion: Total thyroidectomy is a relatively safe treatment option for patients who have simple multinodular goitre. It provides a permanent cure with a low postoperative morbidity risk. The burden of replacement l-thyroxine needs to be discussed ...

  9. Fifteen years medical information sciences: the Amsterdam curriculum

    NARCIS (Netherlands)

    Jaspers, Monique W.; Fockens, Paul; Ravesloot, Jan H.; Limburg, Martien; Abu-Hanna, Ameen

    2004-01-01

    Objectives: To inform the medical informatics community on the rational, goals, evolution and present contents of the Medical Information Sciences program of the University of Amsterdam and our achievements. Methods: We elaborate on the history of our program, the philosophy, contents and

  10. Chernobyl, fifteen years after; Tchernobyl, 15 ans apres

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-04-01

    This work has been constituted around four questions: the future of the Chernobyl site, the damaged reactor, and the sarcophagus around it; the health consequences of the accident on the persons that have worked on the damaged reactor and on the population in the countries the most exposed to fallout,; the situation of contaminated territories around the power plant and their management today; the last question concerns especially the France with the consequences of the radioactive cloud and what we know about the health risks induced by this event. (N.C.)

  11. Fifteen Years of Doing Qualitative Research on Psychotherapy.

    Science.gov (United States)

    Rennie, David L.

    1996-01-01

    Summarizes the author's experience using the grounded theory form of qualitative research. Lists the influences which led to adopting the grounded approach, followed by a section on the use of this methodology. Reviews the experience of publishing qualitative research in mainstream journals, and addresses the challenge of teaching students how to…

  12. CANDU fuel - fifteen years of power reactor experience

    International Nuclear Information System (INIS)

    Fanjoy, G.R.; Bain, A.S.

    1977-05-01

    Analyses of performance statistics, supplemented by examinations of fuel from power reactors and experimental loops have yielded: (a) a thorough understanding of the fundamental behaviour of CANDU fuel; (b) data showing that the predicted high utilization of uranium has been achieved; (c) criteria for operation, which have led to the current very low defect rate of 0.03% of all assemblies and to 'CANLUB' fuel, which has a graphite interlayer between the fuel and sheath to reduce defects on power increases; (d) proof that the short length (500 mm), collapsible cladding features of the CANDU bundle are successful and that the fuel can operate at high-power output (current peak outer-element linear power is 58 +- 15% kW/m). As of mid-1976 over 3 x 10 6 individual elements have been built and over 2 x 10 6 elements have been irradiated. Only six defects have been attributed to faulty materials or fabrication, and the use of high-density UO 2 with low-moisture content precluded defects from hydrogen contamination and densification

  13. CANDU fuel - fifteen years of power reactor experience

    International Nuclear Information System (INIS)

    Fanjoy, G.R.; Bain, A.S.

    1977-01-01

    CANDU (Canada Deuterium Uranium) fuel has operated in power reactors since 1962. Analyses of performance statistics, supplemented by examinations of fuel from power reactors and experimental loops have yielded: (a) A thorough understanding of the fundamental behaviour of CANDU fuel. (b) Data showing that the predicted high utilization of uranium has been achieved. Actual fuelling costs in 1976 at the Pickering Generating Station are 1.2 m$/kWh (1976 Canadian dollars) with the simple oncethrough natural-UO 2 fuel cycle. (c) Criteria for operation, which have led to the current very low defect rate of 0.03% of all assemblies and to ''CANLUB'' fuel, which has a graphite interlayer between the fuel and sheath to reduce defects on power increases. (d) Proof that the short length (500 mm), collapsible cladding features of the CANDU bundle are successful and that the fuel can operate at high-power output (current peak outer-element linear power is 58 +- 15% kW/m). Involvement by the utility in all stages of fuel development has resulted in efficient application of this fundamental knowledge to ensure proper fuel specifications, procurement, scheduling into the reactor and feedback to developers, designers and manufacturers. As of mid-1976 over 3 x 10 6 individual elements have been built in a well-estabilished commercially competitive fuel fabrication industry and over 2 x 10 6 elements have been irradiated. Only six defects have been attributed to faulty materials or fabrication, and the use of high-density UO 2 with low-moisture content precluded defects from hydrogen contamination and densification. Development work on UO 2 and other fuel cycles (plutonium and thorium) is continuing, and, because CANDU reactors use on-power fuelling, bundles can be inserted into power reactors for testing. Thus new fuel designs can be quickly adopted to ensure that the CANDU system continues to provide low-cost energy with high reliability

  14. Fifteen Fine Years of School Construction Progress, 1950-1965.

    Science.gov (United States)

    Milwaukee Public Schools, WI.

    A progress report reviews the Milwaukee School Board's continuous program of acquiring sites and building schools. An itemized listing of 140 completed construction projects is supplemented with pertinent facts and figures, including--(1) growth factors affecting school building needs, (2) resultant increases in the physical plant, staff and…

  15. Fifteen Years of Democracy, 1999-2014: Reflections on Nigeria's ...

    African Journals Online (AJOL)

    DR Nneka

    Nigeria's political class is fragmented and contentious, its institutions largely feeble or dysfunctional. ..... This directly threatens political stability, which is extraordinarily fragile. .... and the perpetual instability in the system. They simply act like ...

  16. Fifteen years of Superfund at South Valley: Reengineering required

    International Nuclear Information System (INIS)

    Cormier, J.; Horak, F.

    1995-01-01

    It is no surprise to many of Superfund's practitioners that the law and its application are flawed. The South Valley Superfund Site in Albuquerque, New Mexico has not escaped Superfund's problems. The problems and issues arising out of the South Valley Superfund site have spurred the desire to seek a better way to administer and manage cleanup. This new method applies organizational and role changes that bring Superfund closer to an efficient business-like entity. This ''Reengineered'' Superfund strives for reorganization, contractor reduction, improved communication, reporting reduction, and teaming. In addition, modifications are made to the roles of regulators, potentially responsible parties (PRPs), and the public. Today the site encompasses roughly one square mile in area, includes six identified contaminant sources, and deals with solvent and petroleum by-product contamination

  17. Performance and experience of DRP-SSD-fifteen year experience

    International Nuclear Information System (INIS)

    Odedra, P.G.

    2002-01-01

    Radiotherapy plays a major role in the treatment of cancer and in developing countries like India, telecobalt units are widely used in rural radiotherapy centers. The measurement of output of these types of telecobalt unit using secondary standard dosimeter is an important duty of medical physicist. There are many sophisticated and costly imported dosimeters like farmer dosimeter and uni dose dosimeter available in the market for the calibration of teletherapy unit. But rural radiotherapy centres can't afford costly imported dosimeters and so output measurements are carried out using cheaper Indian made dosimeters like Control Dynamic Dosimeter (CD- High tech.) or DRP-SSD

  18. Campus Kids Mentoring Program: Fifteen Years of Success

    Science.gov (United States)

    Shepard, Jerri

    2009-01-01

    This article features Campus Kids, a mentoring program located at Gonzaga University in Spokane, Washington. Gonzaga is a Jesuit University with a strong commitment to social justice and humanistic education. Campus Kids began, in the true sense of a community partnership, as an attempt to connect community resources (potential university…

  19. a 5-year evaluation of the effect of introduction of subspecialty

    African Journals Online (AJOL)

    2016. Spine/knee. Paediatrics. Arthroplasty. Pelvis/Acetabulum. Over the 5 year study period, the hospital realized an increase in the number of orthopaedic surgeons from six to fourteen. The number of trainees from. Moi University also increased, gradually increasing the total number of work force in the department of.

  20. Ten years after the introduction of Aldrovanda vesiculosa to the Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Adamec, Lubomír

    2005-01-01

    Roč. 152, č. 2 (2005), s. 239-245 ISSN 1253-8078. [5th Conference of International Carnivorous Plant Society. Lyon, 17.06.2004-21.06.2004] Institutional research plan: CEZ:AV0Z6005908 Keywords : aquatic carnivorous plant , * Třeboňsko Area * dystrophic waters Subject RIV: EF - Botanics Impact factor: 0.224, year: 2005

  1. Evaluation of an Experimental Re-introduction of Sockeye Salmon into Skaha Lake; Year 1 of 3, 2000 Technical Report.

    Energy Technology Data Exchange (ETDEWEB)

    Hammell, Larry (University of Prince Edward Island, Atlantic Veterinary College, Charlottetown, PE, Canada); Machin, Deanna; Long, Karilyn (Okanagan National Fisheries Commission, Westbank, BC, Canada)

    2001-06-01

    Historical records indicate that sockeye salmon were once found in most of the lakes in the Okanagan River Basin. Currently, the only sockeye population within the Okanagan River Basin is found in Osoyoos Lake. Abundance of this stock has declined significantly in the last fifty years. The Okanagan Nation and tribes in the U.S. have proposed re-introducing the species into Okanagan Lake, which has a large rearing capacity. However, assessing the potential benefits and risks associated with a reintroduction of sockeye salmon into Okanagan Lake is difficult because of uncertainties about factors that determine production of Okanagan sockeye, and potential interactions with other species in Okanagan Lake. Associated with this proposal are the potential risks of re-introduction of sockeye salmon into Okanagan Lake. One of these is the effects of sockeye on the resident Okanagan Lake kokanee population, which has declined significantly in the past several years because of habitat loss due to human encroachment, competition with introduced mysid shrimp, and the reduction of biological productivity in the lake as municipalities have moved to more complete effluent treatment. Another concern is the possibility of the transmission of diseases that are currently not found in Okanagan and Skaha lakes from re-introduced sockeye to resident fish. An additional concern is the risk that exotic species (e.g. tench, largemouth bass), that have become established in southern Okanagan Lakes (principally as a result of purposeful introductions in the US Columbia/Okanagan river system), may be able to extend their range to Skaha and Okanagan Lakes, through fish ladders provided at the outlets of Vaseaux (McIntyre Dam) and Skaha Lakes (Okanagan Falls Dam), for natural upstream migration of sockeye. A transboundary multi-agency workshop was hosted in November of 1997 to discuss the potential risks and benefits of reintroducing sockeye salmon into Okanagan Lake. These discussions were

  2. Dynamics of herbaceous vegetation during four years of experimental coppice introduction

    Czech Academy of Sciences Publication Activity Database

    Hédl, Radim; Šipoš, Jan; Chudomelová, Markéta; Utinek, D.

    2017-01-01

    Roč. 52, č. 1 (2017), s. 83-99 ISSN 1211-9520 R&D Projects: GA MŠk(CZ) EE2.3.20.0267 EU Projects: European Commission(XE) 278065 - LONGWOOD Institutional support: RVO:67985939 Keywords : biodiversity * ecological restoration * coppice-with-standards Subject RIV: EH - Ecology, Behaviour OBOR OECD: Plant sciences, botany Impact factor: 1.017, year: 2016

  3. Mont Terri rock laboratory, 20 years of research: introduction, site characteristics and overview of experiments

    International Nuclear Information System (INIS)

    Bossart, P.; Bernier, F.; Birkholzer, J.

    2017-01-01

    Geologic repositories for radioactive waste are designed as multi-barrier disposal systems that perform a number of functions including the long-term isolation and containment of waste from the human environment, and the attenuation of radionuclides released to the subsurface. The rock laboratory at Mont Terri (canton Jura, Switzerland) in the Opalinus Clay plays an important role in the development of such repositories. The experimental results gained in the last 20 years are used to study the possible evolution of a repository and investigate processes closely related to the safety functions of a repository hosted in a clay rock. At the same time, these experiments have increased our general knowledge of the complex behaviour of argillaceous formations in response to coupled hydrological, mechanical, thermal, chemical, and biological processes. After presenting the geological setting in and around the Mont Terri rock laboratory and an overview of the mineralogy and key properties of the Opalinus Clay, we give a brief overview of the key experiments that are described in more detail in the following research papers to this Special Issue of the Swiss Journal of Geosciences. These experiments aim to characterise the Opalinus Clay and estimate safety-relevant parameters, test procedures, and technologies for repository construction and waste emplacement. Other aspects covered are: bentonite buffer emplacement, high-pH concrete-clay interaction experiments, anaerobic steel corrosion with hydrogen formation, depletion of hydrogen by microbial activity, and finally, release of radionuclides into the bentonite buffer and the Opalinus Clay barrier. In the case of a spent fuel/high-level waste repository, the time considered in performance assessment for repository evolution is generally 1 million years, starting with a transient phase over the first 10,000 years and followed by an equilibrium phase. Experiments dealing with initial conditions, construction, and waste

  4. Twenty years of functional near-infrared spectroscopy: introduction for the special issue.

    Science.gov (United States)

    Boas, David A; Elwell, Clare E; Ferrari, Marco; Taga, Gentaro

    2014-01-15

    Papers from four different groups were published in 1993 demonstrating the ability of functional near infrared spectroscopy (fNIRS) to non-invasively measure hemoglobin concentration responses to brain function in humans. This special issue commemorates the first 20years of fNIRS research. The 9 reviews and 49 contributed papers provide a comprehensive survey of the exciting advances driving the field forward and of the myriad of applications that will benefit from fNIRS. Copyright © 2013 Elsevier Inc. All rights reserved.

  5. Mont Terri rock laboratory, 20 years of research: introduction, site characteristics and overview of experiments

    Energy Technology Data Exchange (ETDEWEB)

    Bossart, P. [Swisstopo, Federal Office of Topography, Wabern (Switzerland); Bernier, F. [Federal Agency for Nuclear Control FANC, Brussels (Belgium); Birkholzer, J. [Lawrence Berkeley National Laboratory, Berkeley (United States); and others

    2017-04-15

    Geologic repositories for radioactive waste are designed as multi-barrier disposal systems that perform a number of functions including the long-term isolation and containment of waste from the human environment, and the attenuation of radionuclides released to the subsurface. The rock laboratory at Mont Terri (canton Jura, Switzerland) in the Opalinus Clay plays an important role in the development of such repositories. The experimental results gained in the last 20 years are used to study the possible evolution of a repository and investigate processes closely related to the safety functions of a repository hosted in a clay rock. At the same time, these experiments have increased our general knowledge of the complex behaviour of argillaceous formations in response to coupled hydrological, mechanical, thermal, chemical, and biological processes. After presenting the geological setting in and around the Mont Terri rock laboratory and an overview of the mineralogy and key properties of the Opalinus Clay, we give a brief overview of the key experiments that are described in more detail in the following research papers to this Special Issue of the Swiss Journal of Geosciences. These experiments aim to characterise the Opalinus Clay and estimate safety-relevant parameters, test procedures, and technologies for repository construction and waste emplacement. Other aspects covered are: bentonite buffer emplacement, high-pH concrete-clay interaction experiments, anaerobic steel corrosion with hydrogen formation, depletion of hydrogen by microbial activity, and finally, release of radionuclides into the bentonite buffer and the Opalinus Clay barrier. In the case of a spent fuel/high-level waste repository, the time considered in performance assessment for repository evolution is generally 1 million years, starting with a transient phase over the first 10,000 years and followed by an equilibrium phase. Experiments dealing with initial conditions, construction, and waste

  6. A brief introduction of the constructing work of national radiation monitoring system during the twelfth five-year

    International Nuclear Information System (INIS)

    Liu Hua; Zhao Yongkang; Pan Su; Zhang Jiali; Yang Bin

    2013-01-01

    Radiation monitoring is the technical groundwork of nuclear and radiation safety regulating. In order to overcome the challenges coming with the development of nuclear energy and technology in china, the program of constructing National Radiation Monitoring System (NRMS) was put forward in the twelfth five-year plan of nuclear safety and prevention of radiation pollution, and the view target in 2020. The implementation plan of the constructing of NRMS has been drew up by the Ministry of Environmental Protection in 2012, which including the construction of organization and human resource system, laws and standards system, quality assurance system, technical research and innovation system, and capability insurance system. A brief introduction of the implementation plan was given in the article, the achievements during the eleventh five-year were reviewed, the challenges and working points were analyzed. (authors)

  7. Twenty-five years after introduction of automotive catalysts. What next?

    Energy Technology Data Exchange (ETDEWEB)

    Shelef, M.; McCabe, R.W. [Chemical and Physical Sciences Laboratory, Ford Research Laboratory, Ford Motor Company, MD-3179, SRL, PO Box 2053, 48121 Dearborn, MI (United States)

    2000-09-25

    The union of catalysts and the automobile has been one of the greatest successes of heterogeneous catalysis over the last 25 years. Here, the history of automotive catalysis is briefly reviewed, followed by an assessment of where automotive catalysis stands today and where it is headed in the future. A key distinction between past automotive catalysis experience and that projected for the future is an increased focus on catalysts in upstream of power plant applications, such as on-board fuel processing units for fuel cell vehicles. Driven by ever tighter regulations, there will be continued research and development activity focused also on downstream applications (i.e. exhaust emission aftertreatment), especially for fuel-efficient, lean-burn vehicles, both diesel and spark-ignited.

  8. Survival and Competitiveness of Bradyrhizobium japonicum Strains 20 Years after Introduction into Field Locations in Poland.

    Science.gov (United States)

    Narożna, Dorota; Pudełko, Krzysztof; Króliczak, Joanna; Golińska, Barbara; Sugawara, Masayuki; Mądrzak, Cezary J; Sadowsky, Michael J

    2015-08-15

    It was previously demonstrated that there are no indigenous strains of Bradyrhizobium japonicum forming nitrogen-fixing root nodule symbioses with soybean plants in arable field soils in Poland. However, bacteria currently classified within this species are present (together with Bradyrhizobium canariense) as indigenous populations of strains specific for nodulation of legumes in the Genisteae tribe. These rhizobia, infecting legumes such as lupins, are well established in Polish soils. The studies described here were based on soybean nodulation field experiments, established at the Poznań University of Life Sciences Experiment Station in Gorzyń, Poland, and initiated in the spring of 1994. Long-term research was then conducted in order to study the relation between B. japonicum USDA 110 and USDA 123, introduced together into the same location, where no soybean rhizobia were earlier detected, and nodulation and competitive success were followed over time. Here we report the extra-long-term saprophytic survival of B. japonicum strains nodulating soybeans that were introduced as inoculants 20 years earlier and where soybeans were not grown for the next 17 years. The strains remained viable and symbiotically competent, and molecular and immunochemical methods showed that the strains were undistinguishable from the original inoculum strains USDA 110 and USDA 123. We also show that the strains had balanced numbers and their mobility in soil was low. To our knowledge, this is the first report showing the extra-long-term persistence of soybean-nodulating strains introduced into Polish soils and the first analyzing the long-term competitive relations of USDA 110 and USDA 123 after the two strains, neither of which was native, were introduced into the environment almost 2 decades ago. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  9. [Jonathan Swift's asylum in Dublin--Ireland's introduction to institutional psychiatry 250 years ago].

    Science.gov (United States)

    Reuber, M

    1995-09-01

    250 years ago, the satirical writer and clergyman Jonathan Swift from Dublin (1667-1745) founded the first Irish lunatic asylum. Rejecting the theories put forward by the English philosopher Thomas Hobbes and the doctor Thomas Willis, he was influenced by the ideas of the Scottish doctor and the "enlightened" thinker John Locke. Swift's St. Patrick's Hospital did not, however, realise a new philosophical concept: architecture and therapeutic approach of the new institution were clearly modelled on the much older Hospital of St. Mary of Bethlehem ( = Bedlam). Despite its conservative conceptual basis, the first institution dedicated to the mentally ill and intellectually subnormal in Ireland became a starting point for the apparantly unstoppable expansion of the, at one time, most comprehensive asylum system in the world. After Swift's Hospital had been enlarged twice at the tax-payers' expense (1778, 1793), the administration decided to relieve the institution by erecting the Richmond Asylum (1810), the first public asylum in Ireland. When this establishment also became overcrowded, in 1817, legislation was passed which led to the establishment of the oldest system of public asylums in Europe.

  10. [Evaluation of dysphagia. Results after one year of incorporating videofluoroscopy into its study introduction].

    Science.gov (United States)

    García Romero, Ruth; Ros Arnal, Ignacio; Romea Montañés, María José; López Calahorra, José Antonio; Gutiérrez Alonso, Cristina; Izquierdo Hernández, Beatriz; Martín de Vicente, Carlos

    2017-11-09

    Dysphagia is very common in children with neurological disabilities. These patients usually suffer from respiratory and nutritional problems. The videofluoroscopic swallowing study (VFSS) is the most recommended test to evaluate dysphagia, as it shows the real situation during swallowing. To analyse the results obtained in our centre after one year of the implementation of VFSS, the clinical improvement after confirmation, and the prescription of an individualised treatment for the patients affected. VFSS performed in the previous were collected. The following variables were analysed: age, pathology, degree of neurological damage, oral and pharyngeal and/or oesophageal dysphagia and its severity, aspirations, prescribed treatment, and nutritional and respiratory improvement after diagnosis. A statistical analysis was performed using SPSS v21. A total of 61 VFSS were performed. Dysphagia was detected in more than 70%, being moderate-severe in 58%. Aspirations and/or penetrations were recorded in 59%, of which 50% were silent. Adapted diet was prescribed to 56%, and gastrostomy was performed on 13 (21%) patients. A statistical association was found between neurological disease and severity of dysphagia. The degree of motor impairment is related to the presence of aspirations. After VFSS evaluation and treatment adjustment, nutritional improvement was found in Z-score of weight (+0.3SD) and BMI (+0.4SD). There was respiratory improvement in 71% of patients with dysphagia being controlled in the Chest Diseases Department. After implementation of VFSS, a high percentage of patients were diagnosed and benefited from a correct diagnosis and treatment. VFSS is a fundamental diagnostic test that should be included in paediatric centres as a diagnostic method for children with suspected dysphagia. Copyright © 2017. Publicado por Elsevier España, S.L.U.

  11. Perspectives on transgenic, herbicide-resistant crops in the United States almost 20 years after introduction.

    Science.gov (United States)

    Duke, Stephen O

    2015-05-01

    Herbicide-resistant crops have had a profound impact on weed management. Most of the impact has been by glyphosate-resistant maize, cotton, soybean and canola. Significant economic savings, yield increases and more efficacious and simplified weed management have resulted in widespread adoption of the technology. Initially, glyphosate-resistant crops enabled significantly reduced tillage and reduced the environmental impact of weed management. Continuous use of glyphosate with glyphosate-resistant crops over broad areas facilitated the evolution of glyphosate-resistant weeds, which have resulted in increases in the use of tillage and other herbicides with glyphosate, reducing some of the initial environmental benefits of glyphosate-resistant crops. Transgenic crops with resistance to auxinic herbicides, as well as to herbicides that inhibit acetolactate synthase, acetyl-CoA carboxylase and hydroxyphenylpyruvate dioxygenase, stacked with glyphosate and/or glufosinate resistance, will become available in the next few years. These technologies will provide additional weed management options for farmers, but will not have all of the positive effects (reduced cost, simplified weed management, lowered environmental impact and reduced tillage) that glyphosate-resistant crops had initially. In the more distant future, other herbicide-resistant crops (including non-transgenic ones), herbicides with new modes of action and technologies that are currently in their infancy (e.g. bioherbicides, sprayable herbicidal RNAi and/or robotic weeding) may affect the role of transgenic, herbicide-resistant crops in weed management. Published 2014. This article is a U.S. Government work and is in the public domain in the USA. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.

  12. Introduction of virtual patients onto a final year anesthesia course: Hong Kong experience.

    Science.gov (United States)

    Leung, Joseph Yc; Critchley, Lester Ah; Yung, Alex Lk; Kumta, Shekhar M

    2011-01-01

    e-Learning has revolutionized the way in which undergraduate medical education is delivered. One e-learning tool of note is the virtual patient (VP), a type of computer software that simulates real-life clinical scenarios, in which the learner emulates the role of health care provider to obtain the history, conduct examination, and make diagnoses and management decisions. VPs have been in use since 1993. Early designs were based on serial screen-cards of patient history, examination, investigations, diagnoses, treatment, and outcome, which the learner explored. With the development of web technology, VPs can now be accessed via the Internet and are more versatile, supporting different structural designs to suit a variety of learning objectives, and they can branch via different routes through a case. Using VPs has a number of advantages: 1) VPs improve access to learning material, 2) VPs help learners to acquire higher order cognitive skills like strategic thinking and decision making, 3) VPs provide a safe environment to practice, 4) VPs help to teach interdisciplinary care, and 5) VPs can be used instead of patients for examination. A number of well-known VP player systems are in use today: CASUS, CAMPUS, web-based Simulation of Patients, OpenLabyrinth, and vpSim. At the Chinese University of Hong Kong, we have also developed a web-based VP authoring and player system called Formative Assessment Case Studies (FACS), which is run by our Teaching and Learning Resources Centre. FACS has been integrated into Year-5 Anesthesia teaching since 2006. Three VP products have been developed: Anaesthesia FACS (six cases) that teaches preoperative assessment, Acute Pain Management FACS, and an eight-part longitudinal VP which tells the story of a patient's stay, and anesthesia care, for routine gynecological surgery. Students spend about 3 hours on each during a 2-week clinical attachment. Our VPs have been well received and have overcome problems of providing adequate

  13. Introduction of virtual patients onto a final year anesthesia course: Hong Kong experience

    Directory of Open Access Journals (Sweden)

    Joseph YC Leung

    2011-02-01

    Full Text Available Joseph YC Leung1, Lester AH Critchley1, Alex LK Yung2, Shekhar M Kumta21Department of Anaesthesia and Intensive Care, 2Department of Traumatology and Orthopaedics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong KongAbstract: e-Learning has revolutionized the way in which undergraduate medical education is delivered. One e-learning tool of note is the virtual patient (VP, a type of computer software that simulates real-life clinical scenarios, in which the learner emulates the role of health care provider to obtain the history, conduct examination, and make diagnoses and management decisions. VPs have been in use since 1993. Early designs were based on serial screen-cards of patient history, examination, investigations, diagnoses, treatment, and outcome, which the learner explored. With the development of web technology, VPs can now be accessed via the Internet and are more versatile, supporting different structural designs to suit a variety of learning objectives, and they can branch via different routes through a case. Using VPs has a number of advantages: 1 VPs improve access to learning material, 2 VPs help learners to acquire higher order cognitive skills like strategic thinking and decision making, 3 VPs provide a safe environment to practice, 4 VPs help to teach interdisciplinary care, and 5 VPs can be used instead of patients for examination. A number of well-known VP player systems are in use today: CASUS, CAMPUS, web-based Simulation of Patients, OpenLabyrinth, and vpSim. At the Chinese University of Hong Kong, we have also developed a web-based VP authoring and player system called Formative Assessment Case Studies (FACS, which is run by our Teaching and Learning Resources Centre. FACS has been integrated into Year-5 Anesthesia teaching since 2006. Three VP products have been developed: Anaesthesia FACS (six cases that teaches preoperative assessment, Acute Pain Management FACS, and an

  14. Introduction: A brief journey through the 80 year history of the International Association of Schools of Social Work

    Directory of Open Access Journals (Sweden)

    2008-07-01

    Full Text Available The leaders of the International Association of Schools of Social Work (IASSW have played major roles in shaping the organization over its 80 year history. This brief introduction will put their roles in the context of the organization’s history. While influenced by its presidents in significant ways, the organization’s trajectory has also been affected by the political, economic and social developments of the 20th century and the beginning of the 21st. Significant changes have occurred in the organization and in social work education, yet, as Feustel (2006 observed, “the history of the IASSW demonstrates lines of continuity that are even more remarkable for the fact that it was caught up in the great historical ruptures of the 20th century” (p. 3.

  15. Survival in women with ovarian cancer before and after the introduction of adjuvant paclitaxel; a 25-year, single institution review.

    LENUS (Irish Health Repository)

    Shireen, R

    2012-02-01

    Adjuvant chemotherapy regime for ovarian cancer patients remains to be a contentious issue. The aim of this study was to compare the overall and progression-free survival of women with ovarian cancer before and after introduction of paclitaxel in our unit in 1992. A sample of 112 women who received adjuvant therapy following surgery for ovarian cancer was collected, 68 (61%) received platinum+alkylating agent before 1992 and later 44 (39%) received platinum+paclitaxel. Five-year survival was same in both treatment groups when there was no macroscopic disease after surgery (78% versus 70%) and when residual disease was <2 cm (50% versus 40%). Survival was greater in women with residual disease >2 cm in the platinum+paclitaxel group (50% versus 24%), (p = 0.04). However, progression-free survival was similar in both groups irrespective of stage or residual volume of disease. Therefore consideration to selective use of paclitaxel could reduce patient morbidity and costs significantly.

  16. Impact of routine rotavirus vaccination on all-cause and rotavirus hospitalizations during the first four years following vaccine introduction in Rwanda.

    Science.gov (United States)

    Sibomana, Hassan; Rugambwa, Celse; Mwenda, Jason M; Sayinzoga, Felix; Iraguha, Gisele; Uwimana, Jeanine; Parashar, Umesh D; Tate, Jacqueline E

    2018-05-10

    Rwanda introduced pentavalent rotavirus vaccine into its national immunization program in 2012. To determine the long-term impact of rotavirus vaccine on disease burden in a high burden setting, we examined trends in rotavirus and all-cause diarrhea hospitalizations in the first four years following rotavirus vaccine introduction. We used data from an active surveillance system, from a review of pediatric ward registries, and from the Health Management Information System to describe trends in rotavirus and all-cause diarrhea hospitalizations from January 2009 through December 2016. Percent reductions were calculated to compare the number of all-cause and rotavirus diarrhea hospitalizations pre- and post-rotavirus vaccine introduction. The proportion of diarrhea hospitalizations due to rotavirus declined by 25-44% among all children introduction to 12-13% post-vaccine introduction. In the national hospital discharge data, substantial decreases were observed in all-cause diarrhea hospitalizations among children introduction era. Published by Elsevier Ltd.

  17. Has the incidence of brain cancer risen in Australia since the introduction of mobile phones 29 years ago?

    Science.gov (United States)

    Chapman, Simon; Azizi, Lamiae; Luo, Qingwei; Sitas, Freddy

    2016-06-01

    Mobile phone use in Australia has increased rapidly since its introduction in 1987 with whole population usage being 94% by 2014. We explored the popularly hypothesised association between brain cancer incidence and mobile phone use. Using national cancer registration data, we examined age and gender specific incidence rates of 19,858 male and 14,222 females diagnosed with brain cancer in Australia between 1982 and 2012, and mobile phone usage data from 1987 to 2012. We modelled expected age specific rates (20-39, 40-59, 60-69, 70-84 years), based on published reports of relative risks (RR) of 1.5 in ever-users of mobile phones, and RR of 2.5 in a proportion of 'heavy users' (19% of all users), assuming a 10-year lag period between use and incidence. Age adjusted brain cancer incidence rates (20-84 years, per 100,000) have risen slightly in males (p0.05) and are higher in males 8.7 (CI=8.1-9.3) than in females, 5.8 (CI=5.3-6.3). Assuming a causal RR of 1.5 and 10-year lag period, the expected incidence rate in males in 2012 would be 11.7 (11-12.4) and in females 7.7 (CI=7.2-8.3), both pmobile phones. Modelled expected incidence rates were higher in all age groups in comparison to what was observed. Assuming a causal RR of 2.5 among 'heavy users' gave 2038 expected cases in all age groups. This is an ecological trends analysis, with no data on individual mobile phone use and outcome. The observed stability of brain cancer incidence in Australia between 1982 and 2012 in all age groups except in those over 70 years compared to increasing modelled expected estimates, suggests that the observed increases in brain cancer incidence in the older age group are unlikely to be related to mobile phone use. Rather, we hypothesize that the observed increases in brain cancer incidence in Australia are related to the advent of improved diagnostic procedures when computed tomography and related imaging technologies were introduced in the early 1980s. Copyright © 2016 Elsevier Ltd

  18. Fifteen: Combining Magic Squares and Tic-Tac-Toe

    Science.gov (United States)

    Yeo, Joseph B. W.

    2012-01-01

    Most students love to play games. Ernest (1986) believed that games could be used to teach mathematics effectively in four areas: motivation, concept development, reinforcement of skills, and practice of problem-solving strategies. Fifteen is an interesting and thought-provoking game that helps students learn mathematics at the same time. Playing…

  19. Distribution of rotavirus genotypes associated with acute diarrhoea in Zimbabwean children less than five years old before and after rotavirus vaccine introduction.

    Science.gov (United States)

    Mukaratirwa, Arnold; Berejena, Chipo; Nziramasanga, Pasipanodya; Ticklay, Ismail; Gonah, Archebald; Nathoo, Kusum; Manangazira, Portia; Mangwanya, Douglas; Marembo, Joan; Mwenda, Jason M; Weldegebriel, Goitom; Seheri, Mapaseka; Tate, Jacqueline E; Yen, Catherine; Parashar, Umesh; Mujuru, Hilda

    2018-04-05

    Sentinel surveillance for diarrhoea is important to monitor changes in rotavirus epidemiological trends and circulating genotypes among children under 5 years before and after vaccine introduction. The Zimbabwe Ministry of Health and Child Care introduced rotavirus vaccine in national immunization program in May 2014. Active hospital-based surveillance for diarrhoea was conducted at 3 sentinel sites from 2008 to 2016. Children aged less than 5 years, who presented with acute gastroenteritis as a primary illness and who were admitted to a hospital ward or treated at the emergency unit, were enrolled and had a stool specimen collected and tested for rotavirus by enzyme immunoassay (EIA). Genotyping of positive stools was performed using reverse-transcription polymerase chain reaction and genotyping assays. Pre-vaccine introduction, 10% of all positive stool specimens were genotyped and all adequate positive stools were genotyped post-vaccine introduction. During the pre-vaccine period, a total of 6491 acute gastroenteritis stools were collected, of which 3016 (46%) tested positive for rotavirus and 312 (10%) of the rotavirus positive stools were genotyped. During the post-vaccine period, a total of 3750 acute gastroenteritis stools were collected, of which 937 (25%) tested positive for rotavirus and 784 (84%) were genotyped. During the pre-vaccine introduction the most frequent genotype was G9P[8] (21%) followed by G2P[4] (12%), G1P[8] (6%), G2P[6] (5%), G12P[6] (4%), G9P[6] (3%) and G8P[4] (3%). G1P[8] (30%) was most dominant two years after vaccine introduction followed by G9P[6] (20%), G2P[4] (15%), G9P[8] (11%) and G1P[6] (4%). The decline in positivity rate is an indication of early vaccine impact. Diversity of circulating strains underscores the importance of continued monitoring and strain surveillance after vaccine introduction. Copyright © 2018. Published by Elsevier Ltd.

  20. Methylene blue for vasoplegic syndrome treatment in heart surgery: fifteen years of questions, answers, doubts and certainties Azul de metileno no tratamento da síndrome vasoplégica em cirurgia cardíaca: quinze anos de perguntas, respostas, dúvidas e certezas

    Directory of Open Access Journals (Sweden)

    Paulo Roberto Barbosa Evora

    2009-09-01

    Full Text Available OBJECTIVE: There is strong evidence that methylene blue (MB, an inhibitor of guanylate cyclase, is an excellent therapeutic option for vasoplegic syndrome (VS treatment in heart surgery. The aim of this article is to review the MB's therapeutic function in the vasoplegic syndrome treatment. METHODS: Fifteen years of literature review. RESULTS: 1 Heparin and ACE inhibitors are risk factors; 2 In the recommended doses it is safe (the lethal dose is 40 mg/kg; 3 The use of MB does not cause endothelial dysfunction; 4 The MB effect appears in cases of nitric oxide (NO up-regulation; 5 MB is not a vasoconstrictor, by blocking of the GMPc system it releases the AMPc system, facilitating the norepinephrine vasoconstrictor effect; 6 The most used dosage is 2 mg/kg as IV bolus followed by the same continuous infusion because plasmatic concentrations strongly decays in the first 40 minutes; 7 There is a possible "window of opportunity" for the MB's effectiveness. CONCLUSIONS: Although there are no definitive multicentric studies, the MB used to treat heart surgery VS, at the present time, is the best, safest and cheapest option, being a Brazilian contribution for the heart surgeryOBJETIVO: Existem fortes evidências de que o azul de metileno (AM, um inibidor da guanilato ciclase, é uma excelente opção terapêutica para o tratamento da síndrome vasoplégica (SV em cirurgia cardíaca. O objetivo deste artigo é rever o papel terapêutico do AM no tratamento da SV. MÉTODOS: Revisão da literatura em período de 15 anos. RESULTADOS: 1 A heparina e inibidores da ECA são fatores de risco; 2 Nas doses preconizadas é droga segura (a dose letal é de 40 mg/kg; 3 O AM não causa disfunção endotelial; 4 O efeito do AM só aparece em caso de supra-regulação de óxido nítrico (NO; 5 O AM não é um vasoconstritor, pelo bloqueio do sistema GMPc ele "libera" o sistema AMPc, facilitando o efeito vasoconstritor da noradrenalina; 6 A dosagem mais utilizada é 2

  1. Introduction of an NT-proBNP assay to an acute admission unit--a 2-year audit.

    LENUS (Irish Health Repository)

    Murtagh, Gillian

    2012-02-01

    BACKGROUND: The differential diagnosis of dyspnoea is difficult due to the low predictive value of clinical and laboratory parameters. The elevated levels of NT-proBNP in congestive heart failure may improve diagnostic accuracy. We have evaluated the effect of the introduction of an NT-proBNP assay on hospital length of stay (LOS) and mortality. METHODS: There were 11,853 AMAU patient episodes in the 22 months study period (March 2005-Dec 2006). An NT-proBNP assay was requested in 657 (5.5%) of these. Comparison between categorical variables such as diagnosis, NT-proBNP testing, LOS, and in-hospital mortality was made using Chi-square tests. Literature review suggested that an NT-proBNP cut-off >or=5000 ng\\/L should predict acute in-patient mortality. Logistic regression analysis was used to examine the association between such an elevated NT-proBNP level and outcomes. RESULTS: Of the 396 patients with NT-proBNP <5000 ng\\/L, 8.1% died compared with 22.5% of the 178 patients dying with values >or=5000 ng\\/L (p<0.0001). An NT-proBNP >or=5000 ng\\/L was predictive of both LOS >or=9 days (odds ratios (OR) 1.54 (95% CI 1.06, 2.24: p=0.02) and LOS >or=14 days (OR=1.87 (95% CI 1.29, 2.71: p=0.0009). NT-proBNP requests increased over time, from 2.6% to 8.2% of all patients; the result fell in the diagnostic range for CHF in 60% of requests. CONCLUSION: The introduction of an NT-proBNP was reflected in an appropriate but rapidly increasing pattern of requests from clinicians. High NT-proBNP levels predicted in-hospital mortality and longer LOS in an acute medical population.

  2. Progress in the introduction of the rotavirus vaccine in Latin America and the Caribbean: four years of accumulated experience.

    Science.gov (United States)

    de Oliveira, Lucia Helena; Danovaro-Holliday, M Carolina; Sanwogou, N Jennifer; Ruiz-Matus, Cuauhtemoc; Tambini, Gina; Andrus, Jon Kim

    2011-01-01

    Two effective and safe rotavirus vaccines became available in 2006 and have been recommended for use in all countries by the World Health Organization. This article provides an update on the use of rotavirus vaccine in Latin American and Caribbean (LAC) countries. Data reported by LAC countries to the Pan American Health Organization (PAHO) were reviewed. As of May 2010, 14 LAC countries and 1 territory have introduced the rotavirus vaccine into their national expanded program on immunization (EPI). Reported coverage levels for rotavirus vaccine are lower than those for other EPI vaccines recommended at the same age. A total of 15 LAC countries are part of the PAHO's LAC rotavirus surveillance network; 12 of them are using the vaccine. LAC countries are conducting several studies on rotavirus vaccine effectiveness, cost-effectiveness, and monitoring safety. Also, LAC countries are generating lessons learned on the public health implications of introducing a new vaccine into the EPI. Nine countries and the Cayman Islands pay for the entire cost of the vaccine using government funds. All but 2 countries purchase their rotavirus vaccine through PAHO's Revolving Fund. Rotavirus vaccine introduction in LAC has been faster than for other new vaccines, but coverage levels need to increase to maximize the effect of the intervention. Rotavirus surveillance needs to expand and be strengthened to better assess the effect of vaccine use. LAC countries will continue to provide useful data to monitor rotavirus trends and vaccine effect.

  3. Neuromuscular Monitoring, Muscle Relaxant Use, and Reversal at a Tertiary Teaching Hospital 2.5 Years after Introduction of Sugammadex: Changes in Opinions and Clinical Practice

    Directory of Open Access Journals (Sweden)

    Thomas Ledowski

    2015-01-01

    Full Text Available Sugammadex was introduced to Royal Perth Hospital in early 2011 without access restriction. Two departmental audits (26-page online survey and 1-week in-theatre snapshot audit were undertaken to investigate the change of beliefs and clinical practice related to the use of neuromuscular blocking agents at the Royal Perth Hospital since this introduction. Results were compared with data from 2011. We found that, in the 2.5 years since introduction of Sugammadex, more anesthetists (69.5 versus 38% utilized neuromuscular monitoring, and aminosteroidal neuromuscular blocking agents were used in 94.3% of cases (versus 77% in 2011. Furthermore, 53% of anesthetists identified with a practice of “deeper and longer” intraoperative paralysis of patients. All 71 patients observed during the 5-day in-theatre audit were reversed with Sugammadex. Since the introduction of Sugammadex, 69% (n=20 of respondents felt it provided “faster turnover,” less postoperative residual neuromuscular blockade (n=23; 79%, and higher anesthetist satisfaction (n=17; 59%. 45% (n=13 of colleagues reported that they would feel professionally impaired without the unrestricted availability of Sugammadex, and 1 colleague would refuse to work in a hospital without this drug being freely available. In clinical practice Sugammadex was frequently (57% mildly overdosed, with 200 mg being the most commonly administered dose.

  4. Changes in Perceived Supervision Quality After Introduction of Competency-Based Orthopedic Residency Training: A National 6-Year Follow-Up Study.

    Science.gov (United States)

    van Vendeloo, Stefan N; Brand, Paul L P; Kollen, Boudewijn J; Verheyen, Cees C P M

    2018-04-27

    To evaluate the perceived quality of the learning environment, before and after introduction of competency-based postgraduate orthopedic education. From 2009 to 2014, we conducted annual surveys among Dutch orthopedic residents. The validated Dutch Residency Educational Climate Test (D-RECT, 50 items on 11 subscales) was used to assess the quality of the learning environment. Scores range from 1 (poor) to 5 (excellent). Dynamic cohort follow-up study. All Dutch orthopedic residents were surveyed during annual compulsory courses. Over the 6-year period, 641 responses were obtained (response rate 92%). Scores for "supervision" (95% CI for difference 0.06-0.28, p = 0.002) and "coaching and assessment" (95% CI 0.11-0.35, p < 0.001) improved significantly after introduction of competency-based training. There was no significant change in score on the other subscales of the D-RECT. After the introduction of some of the core components of competency-based postgraduate orthopedic education the perceived quality of "supervision" and "coaching and assessment" improved significantly. Copyright © 2018 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

  5. Substantial Decline in Vaccine-Type Human Papillomavirus (HPV) Among Vaccinated Young Women During the First 8 Years After HPV Vaccine Introduction in a Community

    Science.gov (United States)

    Kahn, Jessica A.; Widdice, Lea E.; Ding, Lili; Huang, Bin; Brown, Darron R.; Franco, Eduardo L.; Bernstein, David I.

    2016-01-01

    Background. Human papillomavirus (HPV) vaccine effectiveness and herd protection are not well established in community settings. Our objective was to determine trends in vaccine-type HPV in young women during the 8 years after vaccine introduction, to assess changes in HPV prevalence and characterize herd protection in a community. Methods. We recruited 3 samples of sexually experienced, 13–26-year-old adolescent girls and young women (hereafter women; N = 1180) from 2006–2014: before widespread vaccine introduction (wave 1) and 3 (wave 2) and 7 (wave 3) years after vaccine introduction. We determined the prevalence of vaccine-type HPV (HPV-6, -11, -16, and -18) among all, vaccinated, and unvaccinated women at waves 1, 2, and 3, adjusted for differences in participant characteristics, then examined whether changes in HPV prevalence were significant using inverse propensity score–weighted logistic regression. Results. Vaccination rates increased from 0% to 71.3% across the 3 waves. Adjusted vaccine-type HPV prevalence changed from 34.8% to 8.7% (75.0% decline) in all women, from 34.9% to 3.2% (90.8% decline) in vaccinated women, and from 32.5% to 22.0% (32.3% decline) in unvaccinated women. Among vaccinated participants, vaccine-type HPV prevalence decreased significantly from wave 1 to wave 2 (adjusted odds ratio, 0.21; 95% confidence interval, .13–.34) and from wave 1 to wave 3 (0.06; .03–.13). The same decreases were also significant among unvaccinated participants (adjusted odds ratios, 0.44; [95% confidence interval, .27–.71] and 0.59; [.35–.98], respectively). Conclusions. The prevalence of vaccine-type HPV decreased >90% in vaccinated women, demonstrating high effectiveness in a community setting, and >30% in unvaccinated women, providing evidence of herd protection. PMID:27655996

  6. Brain Embolism Secondary to Cardiac Myxoma in Fifteen Chinese Patients

    Directory of Open Access Journals (Sweden)

    Youming Long

    2014-01-01

    Full Text Available Background. Heart myxoma-related embolisms commonly involve the central nervous system, but data are lacking in Chinese patients. Methods. 27 patients diagnosed with myxoma were reviewed retrospectively. Results. Among 27 patients, fourteen (51.9% patients were women. Fifteen (55.6% patients had brain embolisms. Rarely, patients were misdiagnosed with central nervous system vasculitis (n = 2, moyamoya disease (n = 1, and neuromyelitis optica (n = 1. We found positive associations between mRS (>3 and female gender (r = 0.873, P10 × 109/L (r = 0.722, P = 0.002, tumour size (r = 0.866, P0.05. Conclusions. Neurologic manifestations in Chinese patients with cardiac myxoma-related stroke were complicated and multifarious. Female gender, infection, other severe complications, low SBP, tumour size, bilateral brain lesions, TACI, and high WBC counts could be associated with a poor prognosis.

  7. Changes in the epidemiology of hepatitis A outbreaks 13 years after the introduction of a mass vaccination program

    Science.gov (United States)

    Martínez, Ana; Broner, Sonia; Sala, M Rosa; Manzanares-Laya, Sandra; Godoy, Pere; Planas, Caritat; Minguell, Sofia; Torner, Nuria; Jané, Mireia; Domínguez, Angela; for the Study of the Immune Status in Health Care, the Working Group; Hepatitis A in Catalonia, for the Study of

    2014-01-01

    A hepatitis A+B vaccine vaccination program of 12-year-olds was introduced in Catalonia in 1998. The aim of this study was to investigate the evolution of hepatitis A outbreaks in Catalonia and estimate the preventable fraction of cases associated with outbreaks as a measure of the impact of the vaccination program. Hepatitis A outbreaks reported to the Health Department between 1991 and 2012 were analyzed. The incidence rates of outbreaks, outbreak-associated cases and hospitalizations were calculated. The preventable fraction (PF) and 95% confidence intervals (CI) were estimated for the whole study period (pre-vaccination and post-vaccination) and the post-vaccination period. One-hundred-eight (108) outbreaks (rate of 2.21 per 106 persons-year) were reported in the pre-vaccination period and 258 outbreaks (rate of 2.82 per 106 persons-year) in the post-vaccination period. The rate of cases associated with outbreaks was 1.52 per 105 persons-year in the pre-vaccination period and 1.28 per 105 persons-year in the post-vaccination period. Hospitalization rates were 0.08 and 0.75 per 106 persons-year, respectively. The number of person-to-person outbreaks whose index case was a school contact decreased in the post-vaccination period (aOR 2.72; 95%CI 1.35–5.48), but outbreaks whose index case was a man who has sex with men (MSM) or an immigrant increased. The PF of all outbreak-associated cases was 6.46% (95%CI 3.11–9.82) and the highest PF was in the 15–24 years age group (42.53%; 95%CI 29.30–55.75). In the 0–4 years age group, the PF was 18.35% (95%CI 9.59–27.11), suggesting a protective herd effect in unvaccinated subjects. Vaccination of immigrants traveling to endemic countries and MSM should be reinforced. PMID:25483535

  8. Introduction to imprecise probabilities

    CERN Document Server

    Augustin, Thomas; de Cooman, Gert; Troffaes, Matthias C M

    2014-01-01

    In recent years, the theory has become widely accepted and has been further developed, but a detailed introduction is needed in order to make the material available and accessible to a wide audience. This will be the first book providing such an introduction, covering core theory and recent developments which can be applied to many application areas. All authors of individual chapters are leading researchers on the specific topics, assuring high quality and up-to-date contents. An Introduction to Imprecise Probabilities provides a comprehensive introduction to imprecise probabilities, includin

  9. Vaccine Adverse Events Reported during the First Ten Years (1998–2008 after Introduction in the State of Rondonia, Brazil

    Directory of Open Access Journals (Sweden)

    Mônica P. L. Cunha

    2013-01-01

    Full Text Available Despite good safety records, vaccines given to young children can cause adverse events. We investigated the reported adverse events following immunization (AEFI of vaccines given to children of less than seven years of age during the first ten years (1998 to 2008 in the state of Rondonia, Brazil. We worked with the events related to BCG (Bacillus Calmett-Guérin, HB (hepatitis B, DTwP/Hib (diphtheria-tetanus-pertussis+Hemophillus influenza b, DTP (diphtheria-tetanus-pertussis, MMR (mumps, measles, rubella, and YF (yellow fever vaccines because they were part of the recommended scheme. The number of doses of vaccines given was 3,231,567 with an average of AEFI of 57.2/year during the studied period. DTwP/Hib was responsible for 298 (57.8%, DTP 114 (22.9%, HB 31 (6%, MMR 28 (5.4%, BCG 24 (4.7%, and YF 20 (3.9% of the reported AEFI. The combination of the AEFI for DTwP/Hib vaccines showed the highest number of systemic (61.4% and local events (33.8%. Young children (≤1-year old were more susceptible to AEFI occurring in the 6 hours (54.2% following vaccine uptake. This study suggests significant differences in reactogenicity of vaccines and that despite limitations of the AEFI Brazilian registry system we cannot ignore underreporting and should use the system to expand our understanding of adverse events and effects.

  10. Using Quantum Mechanics to Facilitate the Introduction of a Broad Range of Chemical Concepts to First-Year Undergraduate Students

    Science.gov (United States)

    deSouza, Romualdo T.; Iyengar, Srinivasan S.

    2013-01-01

    A first-year undergraduate course that introduces students to chemistry through a conceptually detailed description of quantum mechanics is outlined. Quantization as arising from the confinement of a particle is presented and these ideas are used to introduce the reasons behind resonance, molecular orbital theory, degeneracy of electronic states,…

  11. Increase in best practice child car restraint use for children aged 2-5 years in low socioeconomic areas after introduction of mandatory child restraint laws.

    Science.gov (United States)

    Brown, Julie; Keay, Lisa; Hunter, Kate; Bilston, Lynne E; Simpson, Judy M; Ivers, Rebecca

    2013-06-01

    To examine changes in child car restraint practices in low socioeconomic areas following the introduction of mandatory child car restraint legislation in New South Wales (NSW), Australia. Data from two cross-sectional studies of child car restraint use at pre-schools, early childhood centres and primary schools before and after the introduction of legislating mandatory age-appropriate car restraint use for children up to the age of seven years was used in this analysis. All included observations were from local government areas with socioeconomic status in the lowest 30% of urban Sydney. Children aged 2-5 years were observed in their vehicles as they arrived at observation sites (107 pre-legislation, 360 post-legislation). Multilevel logistic regression was used to examine changes in observed age-appropriate and correct use of car restraints. Age-appropriate car restraint use was higher post-legislation than pre-legislation. After controlling for child's age, parental income, language spoken at home and adjusting for clustering, the odds of children being appropriately restrained post-legislation were 2.3 times higher than in the pre-legislation sample, and the odds of them being correctly restrained were 1.6 times greater. Results indicate an improvement in car restraint practices among children aged 2-5 in low socioeconomic areas after introduction of child restraint laws. Implications : Despite improvements observed with enhanced legislation, further efforts are required to increase optimal child car restraint use. © 2013 The Authors. ANZJPH © 2013 Public Health Association of Australia.

  12. The jubilee of medical informatics in bosnia and herzegovina - 20 years anniversary.

    Science.gov (United States)

    Masic, Izet

    2009-01-01

    NONE DECLARED LAST TWO YEARS, THE HEALTH INFORMATICS PROFESSION CELEBRATED FIVE JUBILEES IN BOSNIA AND HERZEGOVINA: thirty years from the introduction of the first automatic manipulation of data, twenty years from the establishment of Society for Medical Informatics BiH, fifteen years from the establishment of the Scientific and Professional Journal of the Society for Medical Informatics of Bosnia and Herzegovina "Acta Informatica Medica", fifteen years on from the establishment of the first Cathedra for Medical Informatics on Biomedical Faculties in Bosnia and Herzegovina and five years on from the introduction of the method of "Distance learning" in medical curriculum. The author of this article are eager to mark the importance of the above mentioned Anniversaries in the development of Health informatics in Bosnia and Herzegovina and have attempted, very briefly, to present the most significant events and persons with essential roles throughout this period.

  13. Age at first introduction of cow milk products and other food products in relation to infant atopic manifestations in the first 2 years of life: the KOALA Birth Cohort Study

    NARCIS (Netherlands)

    Snijders, Bianca E. P.; Thijs, Carel; van Ree, Ronald; van den Brandt, Piet A.

    2008-01-01

    OBJECTIVES: Scientific evidence is scarce about timing of solid-food introduction and its association with the development of atopy. We aimed to evaluate any associations between the introduction of cow milk products/other solid food products and infant atopic manifestations in the second year of

  14. Evaluation of an Experimental Re-introduction of Sockeye Salmon into Skaha Lake; Year 2 of 3, 2001 Technical Report.

    Energy Technology Data Exchange (ETDEWEB)

    Fisher, Christopher (Colville Confederated Tribes, Omak Community Center, Omak, WA); Machin, Deanna; Wright, Howie (Okanagan National Fisheries Commission, Westbank, BC, Canada)

    2002-04-01

    This report summarizes the findings from YEAR 2 of a three-year disease risk assessment. The Okanagan Nation Fisheries Commission (ONFC) and the Colville Confederated Tribes (CCT) are investigating the risks involved in re-introducing sockeye salmon into Skaha Lake, part of their historical range (Ernst and Vedan 2000). The disease risk assessment compares the disease and infection status of fish above and below McIntyre Dam (the present limit of sockeye migration). The disease agents identified that are of a particular concern are: infectious pancreatic necrosis virus (IPNV), infectious haematopoietic necrosis virus type 2 (IHNV type2), erythrocytic inclusion body syndrome virus (EIBSV), the whirling disease agent (Myxobolus cerebralis), and the ceratomyxosis agent (Ceratomyxa shasta).

  15. Geology of Libya Montes and the Interbasin Plains of Northern Tyrrhena Terra, Mars: Project Introduction and First Year Work Plan

    Science.gov (United States)

    Skiner, J. A., Jr.; Rogers, A. D.; Seelos, K. D.

    2009-01-01

    The highland-lowland boundary (HLB) of Mars is interpreted to be a complex tectonic and erosional transition that may hold evidence for past geologic processes and environments. The HLB-abutting margin of the Libya Montes and the interbasin plains of northern Tyrrhena Terra display an exceptional view of the earliest to middle history of Mars that has yet to be fully characterized. This region contains some of the oldest exposed materials on the Martian surface as well as aqueous mineral signatures that may be potential chemical artifacts of early highland formational processes. However, a full understanding of the regions geologic and stratigraphic evolution is remarkably lacking. Some outstanding questions regarding the geologic evolution of Libya Montes and northern Tyrrhena Terra in-clude: Does combining geomorphology and composition advance our understanding of the region s evolution? Can highland materials be subdivided into stratigraphically discrete rock and sediment sequences? What do major physiographic transitions imply about the balanced tectonism, climate change, and erosion? Where is the erosional origin and what is the post-depositional history of channel and plains units? When and in what types of environments did aqueous mineral signatures arise? This abstract introduces the geologic setting, science rationale, and first year work plan of a recently-funded 4-year geologic mapping proposal (project year = calendar year). The objective is to delineate the geologic evolution of Libya Montes and northern Tyrrhena Terra at 1:1M scale using both classical geomorphological and compositional mapping techniques. The funded quadrangles are MTMs 00282, -05282, -10282, 00277, -05277, and -10277.

  16. Introduction of an integrated interactive lecture in the early blocks of 1st year medical students: A pilot study

    Directory of Open Access Journals (Sweden)

    Anudeep Singh

    2016-01-01

    Full Text Available Background: In an integrated curriculum, topics are integrated at the system block level from semester 2 onward. However, in the basic biomedical block, opportunities to integrate also exist which is often overlooked. Aim: A study was conducted to determine the possibility and acceptability of a new pedagogical approach to aid integration of form and function along with the improvement of understanding. Materials and Design: The study was prospective and questionnaire-based, conducted in an upcoming medical college in Malaysia with 1st year medical students. Materials and Methods: An integrated lecture on the autonomic nervous system was planned for the 1st year medical students in their biomedical science block of the first semester by the lecturers from anatomy and physiology and interactive lecture for 1 h and 30 min was delivered. After the session, responses were taken on a structured questionnaire with 10 questions on the Likert scale and a test was conducted to check their understandability. SPSS version 19.1 was used to analyze the results and data were reported based on descriptive statistics and scores were compared by t-test. Results: About 84.2% of the students wanted more lectures of this kind whereas 15.8% disagreed. About 80% stated that proper integration increased their understandability, whereas 83% preferred this modality in comparison to didactic lectures. Conclusions: This pedagogical approach with careful planning can be extended to involve clinical departments thus reaching vertical integration. Including more such integrated interactive sessions will prove to be significant and an effective tool for teaching and learning.

  17. Chytridiomycosis and seasonal mortality of tropical stream-associated frogs 15 years after introduction of Batrachochytrium dendrobatidis.

    Science.gov (United States)

    Phillott, Andrea D; Grogan, Laura F; Cashins, Scott D; McDonald, Keith R; Berger, Lee; Skerratt, Lee F

    2013-10-01

    Assessing the effects of diseases on wildlife populations can be difficult in the absence of observed mortalities, but it is crucial for threat assessment and conservation. We performed an intensive capture-mark-recapture study across seasons and years to investigate the effect of chytridiomycosis on demographics in 2 populations of the threatened common mist frog (Litoria rheocola) in the lowland wet tropics of Queensland, Australia. Infection prevalence was the best predictor for apparent survival probability in adult males and varied widely with season (0-65%). Infection prevalence was highest in winter months when monthly survival probabilities were low (approximately 70%). Populations at both sites exhibited very low annual survival probabilities (12-15%) but high recruitment (71-91%), which resulted in population growth rates that fluctuated seasonally. Our results suggest that even in the absence of observed mortalities and continued declines, and despite host-pathogen co-existence for multiple host generations over almost 2 decades, chytridiomycosis continues to have substantial seasonally fluctuating population-level effects on amphibian survival, which necessitates increased recruitment for population persistence. Similarly infected populations may thus be under continued threat from chytridiomycosis which may render them vulnerable to other threatening processes, particularly those affecting recruitment success. © 2013 Society for Conservation Biology.

  18. The United Kingdom Acid Waters Monitoring Network: a review of the first 15 years and introduction to the special issue

    International Nuclear Information System (INIS)

    Monteith, D.T.; Evans, C.D.

    2005-01-01

    The United Kingdom Acid Waters Monitoring Network (AWMN) was established in 1988 to determine the ecological impact of acidic emissions control policy on acid-sensitive lakes and streams. AWMN data have been used to explore a range of causal linkages necessary to connect changes in emissions to chemical and, ultimately, biological recovery. Regional scale reductions in sulphur (S) deposition have been found to have had an immediate influence on surface water chemistry, including increases in acid neutralising capacity, pH and alkalinity and declines in aluminium toxicity. These in turn can be linked to changes in the aquatic biota which are consistent with 'recovery' responses. A continuation of the current programme is essential in order to better understand apparent non-linearity between nitrogen (N) in deposition and runoff, the substantial rise in organic acid concentrations, and the likely impacts of forecast climate change and other potential constraints on further biological improvement. - After 15 years of the UK Acid Waters Monitoring Network, we can now draw clear conclusions regarding the impact of emission reductions on acidified UK fresh waters

  19. Revisiting reproduction and population structure and dynamics of Procambarus clarkii eight years after its introduction into Lake Trasimeno (Central Italy

    Directory of Open Access Journals (Sweden)

    Dörr A.J.M.

    2013-06-01

    Full Text Available Understanding population dynamics and regulation is fundamental for predicting establishment and spread of invasive alien species. In addition, the population biology of invasive alien species offers an opportunity to study basic ecological processes. In this context, we investigated reproductive and growth plasticity in the invasive crayfish Procambarus clarkii in Lake Trasimeno (central Italy. In total, 3153 crayfish were collected monthly from June 2007 to July 2009. The molt status was assessed by evaluating the exoskeleton hardness. To assess the reproductive cycle, the gonado-somatic and wet hepato-somatic indices were calculated for females. The reproductive status of males was appraised as well. We estimated growth and longevity using the von Bertalanffy growth function, and calculated the total, natural and fishing mortality indices. We then compared our present data with those obtained from the same population eight years before. Our results indicate some changes in population dynamics and in both molting and reproductive periods since the initial invasion of the shallow lake investigated. Long-term differences in the life history of the Trasimeno population may be the result of selective pressures different from those of the native range, but may also result from colonization events and human interference caused by professional fishing activities.

  20. Plasmodium falciparum infection in febrile Congolese children: prevalence of clinical malaria 10 years after introduction of artemisinin-combination therapies.

    Science.gov (United States)

    Etoka-Beka, Mandingha Kosso; Ntoumi, Francine; Kombo, Michael; Deibert, Julia; Poulain, Pierre; Vouvoungui, Christevy; Kobawila, Simon Charles; Koukouikila-Koussounda, Felix

    2016-12-01

    To investigate the proportion of malaria infection in febrile children consulting a paediatric hospital in Brazzaville, to determine the prevalence of submicroscopic malaria infection, to characterise Plasmodium falciparum infection and compare the prevalence of uncomplicated P. falciparum malaria according to haemoglobin profiles. Blood samples were collected from children aged <10 years with an axillary temperature ≥37.5 °C consulting the paediatric ward of Marien Ngouabi Hospital in Brazzaville. Parasite density was determined and all samples were screened for P. falciparum by nested polymerase chain reaction (PCR) using the P. falciparum msp-2 marker to detect submicroscopic infections and characterise P. falciparum infection. Sickle cell trait was screened by PCR. A total of 229 children with fever were recruited, of whom 10% were diagnosed with uncomplicated malaria and 21% with submicroscopic infection. The mean parasite density in children with uncomplicated malaria was 42 824 parasites/μl of blood. The multiplicity of infection (MOI) was 1.59 in children with uncomplicated malaria and 1.69 in children with submicroscopic infection. The mean haemoglobin level was 10.1 ± 1.7 for children with uncomplicated malaria and 12.0 ± 8.6 for children with submicroscopic infection. About 13% of the children harboured the sickle cell trait (HbAS); the rest had normal haemoglobin (HbAA). No difference in prevalence of uncomplicated malaria and submicroscopic infection, parasite density, haemoglobin level, MOI and P. falciparum genetic diversity was observed according to haemoglobin type. The low prevalence of uncomplicated malaria in febrile Congolese children indicates the necessity to investigate carefully other causes of fever. © 2016 John Wiley & Sons Ltd.

  1. Successful introduction of Model for End-stage Liver Disease scoring in deceased donor liver transplantation in Korea: analysis of first 1 year experience at a high-volume transplantation center.

    Science.gov (United States)

    Ha, Soo-Min; Hwang, Shin; Song, Gi-Won; Ahn, Chul-Soo; Moon, Deok-Bog; Ha, Tae-Yong; Jung, Dong-Hwan; Park, Gil-Chun; Kim, Ki-Hun; Kim, Dae-Yeon; Namgung, Jungman; Kang, Woo-Hyoung; Kim, Seok-Hwan; Jwa, Eunkyoung; Kwon, Jae-Hyeon; Cho, Hui-Dong; Jung, Yong-Kyu; Kang, Sang-Hyeon; Lee, Sung-Gyu

    2017-11-01

    Model for End-stage Liver Disease (MELD) score was adopted in June 2016 in Korea. We analyzed changes in volumes and outcomes of deceased donor liver transplantation (DDLT) for 1 year before and after introduction of MELD scoring at Asan Medical Center. There were 64 cases of DDLT in 1 year before MELD introduction and 106 in 1 year after MELD introduction, an increase of 65%. The volume of DDLTs abruptly increased during first 3 months, but then returned to its usual level before MELD introduction, which indicated 3-month depletion of accumulated recipient pool with high MELD scores. The number of pediatric DDLT cases increased from 3 before MELD introduction to 11 after it, making up 21.4% and 47.8% of all cases of pediatric liver transplantation, respectively. The number of cases of retransplanted DDLTs increased from 4 to 27, representing 6.3% and 25.5% of all DDLT cases, respectively. The number of status 1 DDLT cases increased from 5 to 12, being 7.8% and 11.3% of all cases. Patient survival outcomes were similar before and after MELD introduction. The number of DDLTs temporarily increased after adoption of MELD scoring due to accumulated recipient pool with high MELD scores. The numbers of retransplanted and pediatric DDLT cases significantly increased. Patient survival in adult and pediatric DDLT was comparable before and after adoption of MELD scoring. These results imply that Korean MELD score-based allocation system was successfully established within its first year.

  2. ADAMS - Introduction

    International Nuclear Information System (INIS)

    Song, Cheol Gi

    2003-06-01

    This book introduces ADAMS, which is composed of 20 modules ; stamping mechanism, ADAMS introduction, GUI overview failing stone project motion one DOF pendulum inclined plane lift mechanism I mechanism II mechanism III suspension subsystem suspension-steering system spring-damper I spring-damper II hatchback I hatchback II hatchback III cam-rocker-valve target practice recommended practice and switch mechanism workshop.

  3. Introduction; Vvedenie

    Energy Technology Data Exchange (ETDEWEB)

    Nikitin, V I

    1961-07-01

    Introduction describes the present book. Its includes seven chapters. First four from them touch with glycerin of acetylene line-their receiving, studying their oxidation reactions, transformations under the influence of dehydrating methods. Last three chapters dedicated to glycerin of ethylen line-synthesis, their cyclization into substituted dihydropyran.

  4. Fusion: introduction

    International Nuclear Information System (INIS)

    Decreton, M.

    2006-01-01

    The article gives an overview and introduction to the activities of SCK-CEN's research programme on fusion. The decision to construct the ITER international nuclear fusion experiment in Cadarache is highlighted. A summary of the Belgian contributions to fusion research is given with particular emphasis on studies of radiation effects on diagnostics systems, radiation effects on remote handling sensing systems, fusion waste management and socio-economic studies

  5. The impact of generic substitution on the activities of pharmaceutical companies - a survey from the companies' perspective one year and five years after the introduction of generic substitution in finland.

    Science.gov (United States)

    Timonen, Johanna; Bengtström, Marina; Karttunen, Pekka; Ahonen, Riitta

    2010-10-22

    Mandatory generic substitution (GS) was introduced in Finland on 1 April 2003. The aim of this study was to explore and compare the impacts of GS on the activities of pharmaceutical companies representing mainly original or generic pharmaceutical products in Finland. The self-reported impact of GS from pharmaceutical companies' perspective was explored with a focus on the number of employees, the range of sales packages on the market, the marketing activities, the research and development of new pharmaceutical products and storage of pharmaceuticals. A cross-sectional postal survey was conducted among pharmaceutical companies with an office in Finland and substitutable medicines in the Finnish pharmaceutical market one year (2004) and five years (2008) after the introduction of GS. Completed questionnaires were returned by 16 original and 7 generic product companies in 2004 (response rate 56%, n = 41) and by 16 original and 6 generic product companies in 2008 (response rate 56%, n = 39). Descriptive statistical analyses were performed. The number of employees (2004: n = 6/16, 2008: n = 7/16) and the amount of prescription medicine marketing (2004: n = 7/16, 2008: n = 8/16) decreased in many of the original product companies after the introduction of GS. GS resulted in problems related to the storage of pharmaceuticals in the original product companies shortly after GS was introduced (p = 0.032 between 2004 and 2008). In the generic product companies, the prescription medicine representatives' visits to pharmacies increased at the beginning of GS (p = 0.021 between 2004 and 2008). In addition, GS caused problems with the storage of pharmaceuticals one year and five years after the reform (2004: n = 4/7, 2008: n = 3/6). The differences between original and generic product companies regarding the impacts of GS were not, however, statistically significant. GS did not affect on the range of sales packages on the market or the research activities of the majority of

  6. Prevalence of rotavirus genotypes in children younger than 5 years of age before the introduction of a universal rotavirus vaccination program: report of rotavirus surveillance in Turkey.

    Directory of Open Access Journals (Sweden)

    Riza Durmaz

    Full Text Available BACKGROUND: Group A rotaviruses are the most common causative agent of acute gastroenteritis among children less than 5 years of age throughout the world. This sentinel surveillance study was aimed to obtain baseline data on the rotavirus G and P genotypes across Turkey before the introduction of a universal rotavirus vaccination program. METHODS: Rotavirus antigen-positive samples were collected from 2102 children less than 5 years of age who attended hospitals participating in the Turkish Rotavirus Surveillance Network. Rotavirus antigen was detected in the laboratories of participating hospitals by commercial serological tests such as latex agglutination, immunochromatographic test or enzyme immunoassay. Rotavirus G and P genotypes were determined by reverse transcription polymerase chain reaction (RT-PCR using consensus primers detecting the VP7 and VP4 genes, followed by semi-nested type-specific multiplex PCR. RESULTS: RT-PCR found rotavirus RNA in 1644 (78.2% of the samples tested. The highest rate of rotavirus positivity (38.7% was observed among children in the 13 to 24 month age group, followed by children in the age group of 25 to 36 months (28.3%. A total of eight different G types, six different P types, and 42 different G-P combinations were obtained. Four common G types (G1, G2, G3, and G9 and two common P types (P[8] and P[4] accounted for 95.1% and 98.8% of the strains, respectively. G9P[8] was the most common G/P combination found in 40.5% of the strains followed by G1P[8] (21.6%, G2P[8] (9.3%, G2P[4] (6.5%, G3P[8] (3.5%, and finally, G4P[8] (3.4%. These six common genotypes included 83.7% of the strains tested in this study. The rate of uncommon genotypes was 14%. CONCLUSION: The majority of the strains analyzed belonged to the G1-G4 and G9 genotypes, suggesting high coverage of current rotavirus vaccines. This study also demonstrates a dramatic increase in G9 genotype across the country.

  7. Prevalence of Rotavirus Genotypes in Children Younger than 5 Years of Age before the Introduction of a Universal Rotavirus Vaccination Program: Report of Rotavirus Surveillance in Turkey

    Science.gov (United States)

    Durmaz, Riza; Kalaycioglu, Atila Taner; Acar, Sumeyra; Bakkaloglu, Zekiye; Karagoz, Alper; Korukluoglu, Gulay; Ertek, Mustafa; Torunoglu, Mehmet Ali

    2014-01-01

    Background Group A rotaviruses are the most common causative agent of acute gastroenteritis among children less than 5 years of age throughout the world. This sentinel surveillance study was aimed to obtain baseline data on the rotavirus G and P genotypes across Turkey before the introduction of a universal rotavirus vaccination program. Methods Rotavirus antigen-positive samples were collected from 2102 children less than 5 years of age who attended hospitals participating in the Turkish Rotavirus Surveillance Network. Rotavirus antigen was detected in the laboratories of participating hospitals by commercial serological tests such as latex agglutination, immunochromatographic test or enzyme immunoassay. Rotavirus G and P genotypes were determined by reverse transcription polymerase chain reaction (RT-PCR) using consensus primers detecting the VP7 and VP4 genes, followed by semi-nested type-specific multiplex PCR. Results RT-PCR found rotavirus RNA in 1644 (78.2%) of the samples tested. The highest rate of rotavirus positivity (38.7%) was observed among children in the 13 to 24 month age group, followed by children in the age group of 25 to 36 months (28.3%). A total of eight different G types, six different P types, and 42 different G–P combinations were obtained. Four common G types (G1, G2, G3, and G9) and two common P types (P[8] and P[4]) accounted for 95.1% and 98.8% of the strains, respectively. G9P[8] was the most common G/P combination found in 40.5% of the strains followed by G1P[8] (21.6%), G2P[8] (9.3%), G2P[4] (6.5%), G3P[8] (3.5%), and finally, G4P[8] (3.4%). These six common genotypes included 83.7% of the strains tested in this study. The rate of uncommon genotypes was 14%. Conclusion The majority of the strains analyzed belonged to the G1–G4 and G9 genotypes, suggesting high coverage of current rotavirus vaccines. This study also demonstrates a dramatic increase in G9 genotype across the country. PMID:25437502

  8. Electric vehicles in France: A fifteen-year financing plan for massive roll-out

    International Nuclear Information System (INIS)

    Sartor, Oliver; Spencer, Thomas; Fryatt, Oliver

    2017-03-01

    Numerous studies have acknowledged the importance of massive deployment of full battery electric vehicles (BEVs) and plug-in hybrid vehicles (PHEVs), in order to reduce environmental externalities from personal road transport, in particular CO_2 emissions. Good news about declining battery costs and ambitious output pronouncements by major car manufacturers may give the misleading impression that mass-penetration of EVs is just around the corner. But current deployment rates of EVs are significantly off track for deep decarbonization of the French transport system by 2050. In the short to medium term, large scale penetration is far from assured, unless there are further policies to address a number of barriers. In the short term to around 2020-2025, EVs will remain more expensive to purchase and run than equivalent internal combustion engine (ICE) vehicles. In the medium term beyond 2020-2025, EVs are likely to become competitive on a lifetime cost basis. However, they may still confront other financing challenges, such as higher upfront purchase costs (as opposed to lifetime costs). This barrier may be particularly important if consumers are myopic and discount future fuel savings, or if they are credit constrained. In the longer run, EVs will create other challenges for governments to deal with, such as fuel tax revenue erosion. EV support policy should therefore be designed with a dynamic, at least decadal perspective. In this paper, we consider a three-phase financing strategy corresponding to the above described challenges. A range of fiscal policy tools are likely to be needed as part of any feasible regulatory framework for supporting massive EV roll out. But this raises the critical issue of the distributional impacts of the transition to EVs. The upfront financing challenge may be particularly relevant for lower income households, while at the same time, massive roll-out of EVs will require that middle and lower income households start to purchase electric vehicles. This requires that policy consider how to ensure access to EVs for such consumers. The progressive compensation of declining fuel tax revenues through fuel tax increases and the ratcheting up of malus policies on ICEs could also have important distributional impacts. Thus EV support policy should also be designed and monitored with distributional impacts in mind. The EV financing challenge is eminently feasible, and we can be optimistic about the capacity of a judicious policy mix to push the massive deployment of EVs. However, one should not be deluded by the hype currently surrounding EVs: rapid deployment will not occur without a further policy. This policy push should be fiscally neutral if possible; be phased out once the technology reaches maturity; and pay attention to the distributional aspects of policy

  9. The Non-Proliferation Treaty: Fifteen years after entry into force

    International Nuclear Information System (INIS)

    1985-01-01

    The need to halt a wider spread of nuclear weapons grew out of the realization that the increase in the number of countries possessing such weapons would increase the threat to world security. As the Treaty on the Non-Proliferation of Nuclear Weapons clearly states in its preamble, the proliferation of nuclear weapons would seriously enhance the danger of nuclear war. The Treaty - also known as the non-proliferation Treaty - was concluded in 1968, at a time when there were already five nuclear-weapon Powers: the United States, the Soviet Union, the United Kingdom, France and China. This fact sheet is intended to provide background material on the Treaty, including the events that led to its conclusion, an overview of its provisions and the developments at the two previously held Review Conferences

  10. Sudden unexpected death from natural diseases: Fifteen years' experience with 484 cases in Seychelles.

    Science.gov (United States)

    Zhao, Peng; Wang, Ji-Gang; Gao, Peng; Li, Xia; Brewer, Rubell

    2016-01-01

    The aim of this study is to identify and subclassify sudden natural death (sudden death from natural diseases) cases in Seychelles. A total of 484 sudden natural death cases with autopsy at the Clinical Pathology Laboratory, Victoria Hospital, Seychelles between 1997 through 2012 were retrospectively reviewed. Among them, 363 cases (75%) were male and 121 (25%) were female. The most frequent sudden deaths were attributed to cardiovascular diseases (78.5%), and then followed by infectious diseases (9.9%), and gastrointestinal diseases (9.1%). This is the largest population-based study on sudden natural deaths in Seychelles. Copyright © 2015 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

  11. Fifteen years of heating enterprise in southern Finland; Laempoeyrittaejyyttae Uudellamaalla jo 15 vuotta

    Energy Technology Data Exchange (ETDEWEB)

    Vuorio, K.; Lahdensaari-Natt, L., Email: kari.vuorio@tts.fi, Email: liisa.lahdensaari@tts.fi

    2013-06-01

    Heating entrepreneurs produce heat locally and sell heat to the end user at an agreed price. Heat is usually produced by burning wood chips from the companys own forests or from the surrounding forests. There were more than 500 heating plants run by heating entrepreneurs in Finland in the beginning of 2012. Some thirty of them were situated in the area of Uusimaa in southern Finland. It seems that heating entrepreneurship is steadily gaining ground, since the amount of heating plants has increased annually by around twenty. TTS-Tyoetehoseura (Work Efficiency Institute) started the nationwide research and development of heating entrepreneurship in 1993. At that time there were only three heating companies in Finland. The first started to operate in Uusimaa during 1994-1998. Among the first heating plants to be built in 1998 were Perttula Vocational School (KEUDA) with 500 kiloWatts capacity in Nurmijaervi, Ohkola school with 200 kiloWatts capacity in Maentsaelae and the Vaestankvarn schoolfarm with 700 kiloWatts capacity in Inkoo, of which we will give more info about in this bulletin. (orig.)

  12. Changes to the Fossil Record of Insects through Fifteen Years of Discovery

    Science.gov (United States)

    Nicholson, David B.; Mayhew, Peter J.; Ross, Andrew J.

    2015-01-01

    The first and last occurrences of hexapod families in the fossil record are compiled from publications up to end-2009. The major features of these data are compared with those of previous datasets (1993 and 1994). About a third of families (>400) are new to the fossil record since 1994, over half of the earlier, existing families have experienced changes in their known stratigraphic range and only about ten percent have unchanged ranges. Despite these significant additions to knowledge, the broad pattern of described richness through time remains similar, with described richness increasing steadily through geological history and a shift in dominant taxa, from Palaeoptera and Polyneoptera to Paraneoptera and Holometabola, after the Palaeozoic. However, after detrending, described richness is not well correlated with the earlier datasets, indicating significant changes in shorter-term patterns. There is reduced Palaeozoic richness, peaking at a different time, and a less pronounced Permian decline. A pronounced Triassic peak and decline is shown, and the plateau from the mid Early Cretaceous to the end of the period remains, albeit at substantially higher richness compared to earlier datasets. Origination and extinction rates are broadly similar to before, with a broad decline in both through time but episodic peaks, including end-Permian turnover. Origination more consistently exceeds extinction compared to previous datasets and exceptions are mainly in the Palaeozoic. These changes suggest that some inferences about causal mechanisms in insect macroevolution are likely to differ as well. PMID:26176667

  13. Emergency peripartum hysterectomy in the Dubai health system: A fifteen year experience.

    Science.gov (United States)

    Tahlak, Muna Abdulrazzaq; Abdulrahman, Mahera; Hubaishi, Nawal Mahmood; Omar, Mushtaq; Cherifi, Fatima; Magray, Shazia; Carrick, Frederick Robert

    2018-03-01

    To determine the incidence, demographic data, risk factors, indications, outcome and complications of emergency peripartum hysterectomy (EPH) performed in two major tertiary care hospitals in Dubai, and to compare the results with the literature. The records of all women who underwent EPH from January 2000 to December 2015 in two major tertiary care hospitals in Dubai were accessed and reviewed. Maternal characteristics, hysterectomy indications, outcomes, and postoperative complications were recorded using descriptive statistics to describe the cohort. There were 79 EPH out of 168.293 deliveries, a rate of 0.47/1000 deliveries. The most common indications for hysterectomy were abnormal placentation (previa and/or accreta) and uterine atony. The majority of hysterectomies were subtotal (70%). The complications were dominated by massive transfusion, urinary tract injuries, one case of maternal death, and one case of neonatal death. The main indication for EPH was abnormal placentation in scarred uterus and uterine atony. The major method of prevention of EPH is to assess women's risks and to reduce the number of cesarean section deliveries, by limiting the rate of primary cesareans. This is challenging in the United Arab Emirates (UAE) where the culture is for high gravidity and high parity. Recommendations to act to reduce primary and repeated cesareans should be included on the national agenda in UAE.

  14. Jovian discoveries; how Galileo explored the Jovian system fifteen years ago

    NARCIS (Netherlands)

    Willems, T.

    2011-01-01

    Ever since the famous astronomer Galileo Galilei improved his telescope making it possible to look further into space, people have been staring through telescopes into the far distance in search of new worlds. In January 1610 Galilei discovered the four biggest satellites of Jupiter: Io, Europa,

  15. Is Email Business Dying?: A Study on Evolution of Email Spam Over Fifteen Years

    OpenAIRE

    De Wang; Danesh Irani; Calton Pu

    2014-01-01

    With the increasing dedication and sophistication of spammers, email spam is a persistent problem even today. Popular social network sites such as Facebook, Twitter, and Google+ are not exempt from email spam as they all interface with email systems. While some report predicts that email spam business is dying due to the decreasing volume of email spam. Whether email spam business is really dying is an interesting question. In this paper, we analyze email spam trends on Spam Archive dataset, ...

  16. Changes to the Fossil Record of Insects through Fifteen Years of Discovery.

    Directory of Open Access Journals (Sweden)

    David B Nicholson

    Full Text Available The first and last occurrences of hexapod families in the fossil record are compiled from publications up to end-2009. The major features of these data are compared with those of previous datasets (1993 and 1994. About a third of families (>400 are new to the fossil record since 1994, over half of the earlier, existing families have experienced changes in their known stratigraphic range and only about ten percent have unchanged ranges. Despite these significant additions to knowledge, the broad pattern of described richness through time remains similar, with described richness increasing steadily through geological history and a shift in dominant taxa, from Palaeoptera and Polyneoptera to Paraneoptera and Holometabola, after the Palaeozoic. However, after detrending, described richness is not well correlated with the earlier datasets, indicating significant changes in shorter-term patterns. There is reduced Palaeozoic richness, peaking at a different time, and a less pronounced Permian decline. A pronounced Triassic peak and decline is shown, and the plateau from the mid Early Cretaceous to the end of the period remains, albeit at substantially higher richness compared to earlier datasets. Origination and extinction rates are broadly similar to before, with a broad decline in both through time but episodic peaks, including end-Permian turnover. Origination more consistently exceeds extinction compared to previous datasets and exceptions are mainly in the Palaeozoic. These changes suggest that some inferences about causal mechanisms in insect macroevolution are likely to differ as well.

  17. FIFTEEN-YEAR RADIOTHERAPY OUTCOMES OF THE RANDOMIZED PORTEC-1 TRIAL FOR ENDOMETRIAL CARCINOMA

    NARCIS (Netherlands)

    Creutzberg, Carien L.; Nout, Remi A.; Lybeert, Marnix L. M.; Warlam-Rodenhuis, Carla C.; Jobsen, Jan J.; Mens, Jan-Willem M.; Lutgens, Ludy C. H. W.; Pras, Elisabeth; van de Poll-Franse, Lonneke V.; van Putten, Wim L. J.

    2011-01-01

    Purpose: To evaluate the very long-term results of the randomized Post Operative Radiation Therapy in Endometrial Carcinoma (PORTEC)-1 trial for patients with Stage I endometrial carcinoma (EC), focusing on the role of prognostic factors for treatment selection and the long-term risk of second

  18. Fifteen years of the cuban program, with children from areas affected by the Chernobyl accident

    International Nuclear Information System (INIS)

    Garcia, Omar; Medina, Julio

    2005-01-01

    The Cuban Chernobyl Program arrived to the 15th anniversary in March 2005. This program was designed to offers specialised medical attention and to develop a rehabilitation plan with children from areas affected by the Chernobyl accident. More than 21 500 children and adults had been assisted in the program up to the moment, with a significant set of medical procedures done. Dosimetric and biomedic research had been also carried out as part of the program. The most significant medical attention activities include the treatment of children with haematological disorders, including 120 leukaemia, bone marrow transplants, and the treatment of endocrine and cancer diseases. The dosimetric studies allow made a data base with information on internal 137Cs contamination, internal, external and total doses, children living location, and its contamination by 137Cs, and other significant information for radiological impact evaluation in more than 8000 children. The behaviour of all the medical information of the program in relation to the contamination of the land and the internal contamination of the children was analysed using this database. The program has accumulated an experience of interest for physicians, psychologists and in general persons interested in Chernobyl consequences. This paper present a summary of the main results obtained in the program

  19. Training medical students in human rights: a fifteen-year experience in Geneva

    Directory of Open Access Journals (Sweden)

    Philippe Chastonay

    2012-09-01

    Full Text Available Background: Training health professionals in the field of human rights has long been advocated by the United Nations. Over the past decade some medical schools have introduced health and human rights courses, yet by far not all. This paper describes the objectives and the content of the Health and Human Rights program developed at the Faculty of Medicine, University of Geneva. Methods: The health and human rights program was developed through the identification of the course objectives, contents, and educational modalities using consensus techniques, and through a step by step implementation procedure integrating multiple evaluation processes. Results: Defined objectives included the familiarization with the concepts, instruments and mechanisms of human rights, the links between health and human rights, and the role of health professionals in promoting human rights. The content ultimately adopted focused on the typology of human rights, their mechanisms of protection, their instruments, as well as social inequalities and vulnerable groups of the population. The implementation proceeded through a step by step approach. Evaluation showed high satisfaction of students, good achievement of learning objectives, and some academic and community impact. Conclusions: High interest of students for a human rights course is encouraging. Furthermore, the community projects initiated and implemented by students may contribute to the social responsibility of the academic institution.

  20. The final fifteen feet of hose : the Canadian gasoline industry in the year 2000

    International Nuclear Information System (INIS)

    Sperber, M.; Beckman, K.; Clavet, F.; Bernard, M.-C.; Bussiere, L.; Frank, J.; Lefebvre, M.

    2001-01-01

    An up-to-date profile of the Canadian gasoline industry was presented with an effort to address some of the preoccupations of industry stakeholders and the perceptions of Canadian motorists. This study provides new insights into the workings of the industry by providing a balanced perspective on the many contentious issues that affect the industry, particularly retail pricing. The Conference Board's empirical analysis makes use of a new approach which provides a better understanding of how retail prices react to changes in wholesale prices. Competition is the reason why a retail market outcome margin exists in each city based on local conditions. This margin is the basis for price changes in that market and reflects a margin at which most competitors are able to sustain themselves. When changes occur in the wholesale price of crude, the retail price is adjusted depending on whether the actual margin in place is higher or lower than the market outcome margin. Crude oil and taxes make up about 84 per cent of the average price of a litre of regulated unleaded gasoline. The main reason for rising Canadian gasoline prices is the rapid increase in world crude oil prices. The volatility in gasoline prices is a direct result of the competitive nature of the business at the street level and the uniformity of prices reflects the rapid response of individual dealers to the actions of their competitors. Each outlet has fixed costs to cover, therefore average sales volumes per outlet have an important impact on retail margins and prices. It was also emphasized that there is no empirical proof that gasoline prices increase before long weekends, nor is there any proof of asymmetry in price adjustment in the retail market. It was noted that the price of gasoline in Canada and the United States, excluding taxes, is very similar. 15 tabs., 59 figs

  1. Fifteen years' review of advanced childhood neuroblastoma from a single institution in Hong Kong.

    Science.gov (United States)

    Leung, C K

    1998-05-01

    To assess the progress in the treatment of advanced childhood neuroblastoma. From 1981 to 1996, there were 32 children with neuroblastoma (NB) diagnosed, staged and treated in our institution. There were 4 patients with stage II NB (12%), 5 stage III (16%), 21 stage IV (66%) and 2 stage IV s (6%). The NBs were excised if CT scan indicated that the tumors were operable. For advanced NB, stages III and IV, multiple drug chemotherapy was started first and operability was assessed with serial CT scan examinations. Once the X-ray imaging indicated the tumors were operable, surgical interventions were done. The medical records of the advanced NB were reviewed. In the initial period of the study, 9 patients were treated using the VAC protocol [vincristine (vcr), adriamycin (adria) and cyclophosphamide (cyc)]. No patient was convertible to operable and all died with a mean survival of 10 months. OPEC [vcr, cyc, VM26, cisplatin (cis)], Rapid COJEC (carboplatin, VP16, vcr, cis and cyc) and more recently N6 protocol (cyc, adria, vcr, VP16, cis) was used for 17 patients. 80% of them were converted to operable. In 4 patients, surgical specimens showed only necrotic tissue without viable tumor tissue and 6 (35%) tumors were converted to ganglioneuroma or ganglioneuroblastoma. Although 2 (12%) patients died of fungal septicemia and 1 (6%) developed Fanconi's syndrome after chemotherapy, the mean survival period increased to 27 months. In the 10 survivors (60%), 4 had megatherapy with melphalan followed by autologous peripheral blood stem cell (PBSC) transplantation and 2 were waiting for transplantation. There is a high percentage of advanced NB on presentation in Hong Kong. With more potent multiple drug chemotherapy for advanced stage NB there are (1) improvement in the survival of these patients, (2) opportunities for more operations for tumor excision and (3) opportunities for autologous PBSC transplantation for better tumor eradication.

  2. Experimental infection of human volunteers with Haemophilus ducreyi: fifteen years of clinical data and experience.

    Science.gov (United States)

    Janowicz, Diane M; Ofner, Susan; Katz, Barry P; Spinola, Stanley M

    2009-06-01

    Haemophilus ducreyi causes chancroid, which facilitates transmission of human immunodeficiency virus type 1. To better understand the biology of H. ducreyi, we developed a human inoculation model. In the present article, we describe clinical outcomes for 267 volunteers who were infected with H. ducreyi. There was a relationship between papule formation and estimated delivered dose. The outcome (either pustule formation or resolution) of infected sites for a given subject was not independent; the most important determinants of pustule formation were sex and host effects. When 41 subjects were infected a second time, their outcomes segregated toward their initial outcome, confirming the host effect. Subjects with pustules developed local symptoms that required withdrawal from the study after a mean of 8.6 days. There were 191 volunteers who had tissue biopsy performed, 173 of whom were available for follow-up analysis; 28 (16.2%) of these developed hypertrophic scars, but the model was otherwise safe. Mutant-parent trials confirmed key features in H. ducreyi pathogenesis, and the model has provided an opportunity to study differential human susceptibility to a bacterial infection.

  3. Meta-Interpretation: Fifteen Years of Research with the Management Report

    Directory of Open Access Journals (Sweden)

    Uajará Pessoa Araújo

    2016-08-01

    Full Text Available ABSTRACT This paper deals with Brazilian empirical research published in journals between 2000 and mid-2015 that used, as a source of data, the Management Reports (MRs released by publicly-traded companies together with their financial statements. MRs differ from each other, both in form as well as in substance, and due to this as well as to their other characteristics, they prove attractive for academic studies interested in official company discourse, more so because they involve documents that are public and retrievable over time, covering a substantial range of typically larger companies from different economic sectors. Driven by these characteristics, the goal of this study was to understand the way the academic world understands and uses the MR. The paper favored an interpretivist viewpoint, but used the triangulation allowed by the use of qualitative (content analysis and quantitative (statistical, sociometric, and bibliometric analyses methods. It was concluded that, for the core group of experts who dealt with the document, the MR is biased, incomplete, questionable, unclear, laborious, uncertain, but also useful - in the absence of another -, comprehensive, available, and retrievable over time. And it lends itself to the interest of company directors by increasing their value and at the same time legitimizing their companies, incorporating into discourse the use of contemporary management practices, consistent with the expectations of stakeholders. Finally, it suggests the possibility, unexplored in the articles analyzed, of employing the MR to study the dynamics of the institutionalization of administrative practices among companies in the country.

  4. Budd Chiari Syndrome in a Fifteen-Year Old Girl with Systemic ...

    African Journals Online (AJOL)

    It is believed that in this patient, Budd Chiari Syndrome resulted from hepatic veinous thrombosis due to the presence of Lupus anticoagulants. As the young girl was suffering from antiphospholipid syndrome secondary to lupus, this milder form of Budd-Chiari Syndrome was later treated in India with surgical shunts.

  5. Synergistic Use of Satellite Volcano Detection and Science: A Fifteen Year Perspective of ASTER on Terra

    Science.gov (United States)

    Ramsey, M. S.

    2014-12-01

    The success of Terra-based observations using the ASTER instrument of active volcanic processes early in the mission gave rise to a funded NASA program designed to both increase the number of ASTER observations following an eruption and validate the satellite data. The urgent request protocol (URP) system for ASTER grew out of this initial study and has now operated in conjunction with and the support of the Alaska Volcano Observatory, the University of Alaska Fairbanks, the University of Hawaii, the USGS Land Processes DAAC, and the ASTER science team. The University of Pittsburgh oversees this rapid response/sensor-web system, which until 2011 had focused solely on the active volcanoes in the North Pacific region. Since that time, it has been expanded to operate globally with AVHRR and MODIS and now ASTER VNIR/TIR data are being acquired at numerous erupting volcanoes around the world. This program relies on the increased temporal resolution of AVHRR/MODIS midwave infrared data to trigger the next available ASTER observation, which results in ASTER data as frequently as every 2-5 days. For many targets, the URP has increased the observational frequency over active eruptions by as much 50%. The data have been used for operational response to new eruptions, longer-term scientific studies such as capturing detailed changes in lava domes/flows, pyroclastic flows and lahars. These data have also been used to infer the emplacement of new lava lobes, detect endogenous dome growth, and interpret hazardous dome collapse events. The emitted TIR radiance from lava surfaces has also been used effectively to model composition, texture and degassing. Now, this long-term archive of volcanic image data is being mined to provide statistics on the expectations of future high-repeat TIR data such as that proposed for the NASA HyspIRI mission. In summary, this operational/scientific program utilizing the unique properties of ASTER and the Terra mission has shown the potential for providing innovative and integrated synoptic measurements of geothermal activity, volcanic eruptions and their subsequent hazards globally.

  6. Fifteen Years On: An Examination of the Irish Famine Curricula in New York and New Jersey

    Science.gov (United States)

    Feeley, Christopher J.

    2014-01-01

    Since the early 1980s Holocaust education and genocide studies programs at the primary, secondary and post-secondary educational levels have become commonplace and an accepted element of public school curriculum. As these programs and their curricula gained acceptance within public education, efforts to increase awareness of genocidal events…

  7. Fifteen years experience with finger arterial pressure monitoring : Assessment of the technology

    NARCIS (Netherlands)

    Imholz, B.P.M.; Wieling, W.; Montfrans, G.A. van; Wesseling, K.H.

    1998-01-01

    We review the Finapres technology, embodied in several TNO-prototypes and in the Ohmeda 2300 and 2300e Finapres NIBP. Finapres is an acronym for FINger Arterial PRESsure, the device delivers a continuous finger arterial pressure waveform. Many papers report on the accuracy of the device in

  8. Fifteen years experience with finger arterial pressure monitoring: assessment of the technology

    NARCIS (Netherlands)

    Imholz, B. P.; Wieling, W.; van Montfrans, G. A.; Wesseling, K. H.

    1998-01-01

    We review the Finapres technology, embodied in several TNO-prototypes and in the Ohmeda 2300 and 2300e Finapres NIBP. Finapres is an acronym for FINger Arterial PRESsure, the device delivers a continuous finger arterial pressure waveform. Many papers report on the accuracy of the device in

  9. Prairie revegetation of a strip mine in Illinois: fifteen years after establishment

    Energy Technology Data Exchange (ETDEWEB)

    Corbett, E.A.; Anderson, R.C.; Rodgers, C.S. [Illinois State University, Normal, IL (United States). Dept. of Biological Sciences

    1996-12-01

    The long-term success of prairie planting on a former strip mine in northeastern Illinois was investigated. The site was reclaimed and planted with prairie species in the 1970s. Total biomass increased over time, largely as a result of an increase in biomass of non-prairie species. Biomass of prairie species remained unchanged because of an increase in Panicum virgatum (switchgrass) offsetting decreases in Sorghastrum nutans (Indian grass).

  10. Lead levels in tissues and stomach contents of poisoned cattle: a fifteen-year survey

    Energy Technology Data Exchange (ETDEWEB)

    Hatch, R C; Funnell, H S

    1969-10-01

    During the period 1954 to 1969, samples of ingesta, liver, or kidney from 175 cattle which died of lead poisoning were analyzed for lead content. The average lead levels, and the extremes, were: ingesta, 3427 ppm (zero to 146,200 ppm); liver, 43 ppm (zero to 1300 ppm); and kidney, 137 ppm (two to 2355 ppm). There were no relationships between ingesta levels of lead and levels in the tissues tested. Taken with published results of natural and experimental lead poisoning in other cattle, the data indicate that the mere presence of lead in kidney (or liver) and ingesta should lead to a presumptive diagnosis of lead poisoning in cattle which die with signs, lesions, and histories characteristic of lead poisoning. Diagnosis may be confirmed by proof of access to, or ingestion of, a source of lead.

  11. Introduction to adaptive arrays

    CERN Document Server

    Monzingo, Bob; Haupt, Randy

    2011-01-01

    This second edition is an extensive modernization of the bestselling introduction to the subject of adaptive array sensor systems. With the number of applications of adaptive array sensor systems growing each year, this look at the principles and fundamental techniques that are critical to these systems is more important than ever before. Introduction to Adaptive Arrays, 2nd Edition is organized as a tutorial, taking the reader by the hand and leading them through the maze of jargon that often surrounds this highly technical subject. It is easy to read and easy to follow as fundamental concept

  12. ADHD and Other Associated Developmental Problems in Children with Mild Mental Retardation. The Use of the "Five-To-Fifteen" Questionnaire in a Population-Based Sample

    Science.gov (United States)

    Lindblad, Ida; Gillberg, Christopher; Fernell, Elisabeth

    2011-01-01

    The aim was to examine the rates and types of parent reported neuropsychiatric problems in children and adolescents with mild mental retardation (MMR) (mild intellectual disability/UK) using the Five-To-Fifteen questionnaire (FTF). The target group comprised all pupils with clinically diagnosed MMR, aged between 7 and 15 years, attending the…

  13. Squamous cell carcinoma of the conjunctiva: analysis of fifteen cases

    International Nuclear Information System (INIS)

    Baig, M.S.A.; Dareshani, S.; Ali, M.A.; Khan, M.S.

    2009-01-01

    To document various clinical presentations and management options of conjunctival squamous cell carcinoma (CSCC) in patients attending ophthalmic out patients department (OPD) of a tertiary care centre. This case series was carried out in the Department of Ophthalmology Civil Hospital and, Dow University of Health Sciences, Karachi and were reviewed from June 2004 to December 2007. Socio-demographic data and clinical features of patients with biopsy proven conjunctival squamous cell carcinoma were recorded and analysed. All patients underwent complete ophthalmic examination by a fellow ophthalmologist and clinical findings were recorded on a prescribed Performa. Data was analysed in terms of frequency, means and median by SPSS for windows V.15. Seventy-two percent of the patients were male and 28% were female, more than 80% of patients were in the age group of seventy years and above. Eighteen percent of patients developed intraocular invasion and the eyes had to be enucleated. CSCC occurs in sun damaged ocular surface usually at limbus, elderly men are more commonly involve, recurrence is a feature of disease and high risk in older individual. In our treatment we used various therapies, excision with clear margin, topical mitomycin C adjunctive cryotherapy and amniotic graft. (author)

  14. Elaboration, validation and standardization of the five to fifteen (FTF) questionnaire in a Danish population sample.

    Science.gov (United States)

    Lambek, Rikke; Trillingsgaard, Anegen

    2015-03-01

    The five to fifteen (FTF) is a parent questionnaire developed to assess ADHD, its common comorbid conditions and associated problems in children and adolescents. The present study examined (1) the psychometric properties of scores on the new teacher version of the FTF, (2) competing models of the FTF subdomain structure and (3) the psychometric properties and utility of scores on the newly developed FTF impact questions. Parents (n=4258) and teachers (n=1298) of Danish children and adolescents (ages 5 to 17 years), selected using simple random sampling, completed the FTF. In the largest study of the FTF to date, parent and teacher scores had acceptable psychometric properties. The FTF subdomains were organized into six domains labelled cognitive skills, motor/perception, emotion/socialization/behaviour, attention, literacy skills and activity control and analysis of these domains may provide additional information when applying the FTF in the future. The impact questions yielded information above and beyond that provided by symptom count alone and appeared to increase the ability of the FTF to identify at risk children and adolescents. Copyright © 2014 Elsevier Ltd. All rights reserved.

  15. An Introduction to Spoken Bolivian Quechua.

    Science.gov (United States)

    Bills, Garland D.; And Others

    This text is intended for use in a college-level course in Bolivian Quechua for speakers of English. It is divided into thirty units and is specifically designed for a two-semester academic year of fifteen weeks a semester. The entire text is highly structured, carefully graded, and organized on the principles of the audiolingual approach to…

  16. Introduction: Righting Feminism

    OpenAIRE

    Farris, Sara R.

    2017-01-01

    This is the introduction to a special issue on Righting Feminism. In recent years, we have witnessed the multifarious ways in which feminism as an emancipatory project dedicated to women's liberation has increasingly “converged” with non-emancipatory/racist, conservative, and neo-liberal economic and political agendas. Today, feminist themes are not only being "mainstreamed" but are also increasingly being mobilized to bolster existing power hierarchies as well as neo-liberal and right-wing x...

  17. Introduction pages

    Directory of Open Access Journals (Sweden)

    Radu E. Sestras

    2015-09-01

    Full Text Available Introduction Pages and Table of Contents Research ArticlesInsulin Requirements in Relation to Insulin Pump Indications in Type 1 DiabetesPDFGabriela GHIMPEŢEANU,\tSilvia Ş. IANCU,\tGabriela ROMAN,\tAnca M. ALIONESCU259-263Comparative Antibacterial Efficacy of Vitellaria paradoxa (Shea Butter Tree Extracts Against Some Clinical Bacterial IsolatesPDFKamoldeen Abiodun AJIJOLAKEWU,\tFola Jose AWARUN264-268A Murine Effort Model for Studying the Influence of Trichinella on Muscular Activity of MicePDFIonut MARIAN,\tCălin Mircea GHERMAN,\tAndrei Daniel MIHALCA269-271Prevalence and Antibiogram of Generic Extended-Spectrum β-Lactam-Resistant Enterobacteria in Healthy PigsPDFIfeoma Chinyere UGWU,\tMadubuike Umunna ANYANWU,\tChidozie Clifford UGWU,\tOgbonna Wilfred UGWUANYI272-280Index of Relative Importance of the Dietary Proportions of Sloth Bear (Melursus ursinus in Semi-Arid RegionPDFTana P. MEWADA281-288Bioaccumulation Potentials of Momordica charantia L. Medicinal Plant Grown in Lead Polluted Soil under Organic Fertilizer AmendmentPDFOjo Michael OSENI,\tOmotola Esther DADA,\tAdekunle Ajayi ADELUSI289-294Induced Chitinase and Chitosanase Activities in Turmeric Plants by Application of β-D-Glucan NanoparticlesPDFSathiyanarayanan ANUSUYA,\tMuthukrishnan SATHIYABAMA295-298Present or Absent? About a Threatened Fern, Asplenium adulterinum Milde, in South-Eastern Carpathians (RomaniaPDFAttila BARTÓK,\tIrina IRIMIA299-307Comparative Root and Stem Anatomy of Four Rare Onobrychis Mill. (Fabaceae Taxa Endemic in TurkeyPDFMehmet TEKİN,\tGülden YILMAZ308-312Propagation of Threatened Nepenthes khasiana: Methods and PrecautionsPDFJibankumar S. KHURAIJAM,\tRup K. ROY313-315Alleviate Seed Ageing Effects in Silybum marianum by Application of Hormone Seed PrimingPDFSeyed Ata SIADAT,\tSeyed Amir MOOSAVI,\tMehran SHARAFIZADEH316-321The Effect of Halopriming and Salicylic Acid on the Germination of Fenugreek (Trigonella foenum-graecum under Different Cadmium

  18. Editor's Introduction

    OpenAIRE

    Wiley, Jennifer

    2016-01-01

    As noted in the last bibliography of Human Problem Solving compiled by Joachim Funke and reported in the Journal of Problem Solving in 2013, problem solving as a concept and as a research issue has been gaining more interest than ever before. Now in 2016, we can see that publications on the topic further increased to around 1,800 per year in both 2013 and 2014. The papers in this special issue come from two areas of problem solving research, mathematical and creative problem solving, which re...

  19. Changes in brain magnetic resonance imaging patterns for preterm infants after introduction of a magnetic resonance-compatible incubator coil system: 5-year experience at a single institution.

    Science.gov (United States)

    Cho, Hyun-Hae; Kim, In-One; Cheon, Jung-Eun; Choi, Young Hun; Lee, So Mi; Kim, Woo Sun

    2016-09-01

    To evaluate the changes in using patterns of brain magnetic resonance imaging (MRI) in preterm infants after introduction of a MR-compatible incubator coil system. Brain MRIs for preterm infants with the MR-compatible incubator coil from March 2010 to July 2014 (n=154, group A) were compared with MRIs prior to the introduction of the incubator coil, from March 2005 to February 2010 (n=65, group B). Clinical data, MRI findings, acquisition time, and incidence of adverse events during the study were retrospectively reviewed. For the qualitative analysis of the examinations, the presence of motion artefact, spatial resolution, and overall image quality were assessed. Signal uniformity of each sequence was evaluated for a quantitative comparison. Comparing with group B, Group A was significantly younger (36+3 vs. 38+3 weeks, pimage acquisition time was significantly shorter in group A (21.4±4.5 vs. 25.4±5.5min, pimage quality with decreased signal variation than group B (all pimage quality. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  20. Comparison of the ability of fifteen onion (Allium cepa L. cultivars to accumulate nitrates

    Directory of Open Access Journals (Sweden)

    Renata Wojciechowska

    2014-04-01

    Full Text Available The aim of a two-year study was to characterise selected Allium cepa L. genotypes with regard to their ability to accumulate nitrates in bulbs as well as to search for a possible relation between NO3- concentration and dry matter content. Fifteen cultivars of edible onion, mostly of long-day genotype with different growing periods, bulb size and skin colour, were taken for the experiment. Seeds of particular cultivars were obtained from the following seed companies: Spójnia Nochowo (‘Labrador’, ‘Takstar F1’,‘Tęcza’, ‘Warna’, ‘Zorza’, Polan (‘Polanowska’, ‘Topolska’, PlantiCo Gołębiew (‘Alibaba’, ‘Efekt’, ‘Kristine’, ‘Niagara F1’,and PlantiCo Zielonki (‘Bila’, ‘Irka’, ‘Wenta’, ‘Zeta’. Plants produced from seedlings were grown in the experimental field of the University of Agriculture in Kraków. After crop harvesting and additional drying, nitrate and dry matter content in bulbs of all cultivars were measured. The following cultivars: ‘Efekt’, ‘Labrador’ and red-skinned ‘Wenta’, were characterized by the lowest ability to accumulate NO3- in bulbs. The highest nitrate content was noted in bulbs of ‘Takstar F1’ (a very early-season cultivar, followed by ‘Bila’ and ‘Tęcza’. A weak, yet statistically significant negative correlation between nitrate and dry matter content was observed. The highest dry matter content was determined in bulbs of white-skinned ‘Alibaba’, while the lowest – in brown-skinned ‘Labrador’.

  1. Introduction of interdisciplinary teaching: two case studies : commentary on "teaching science, technology, and society to engineering students: a sixteen year journey".

    Science.gov (United States)

    Spitzer, Hartwig

    2013-12-01

    Interdisciplinary courses on science, engineering and society have been successfully established in two cases, at Bilkent University, Ankara, Turkey, and at the University of Hamburg, Germany. In both cases there were institutional and perceptual barriers that had to be overcome in the primarily disciplinary departments. The ingredients of success included a clear vision of interdisciplinary themes and didactics, and the exploitation of institutional opportunities. Haldun M. Ozaktas in Ankara used the dynamics of an accreditation process to establish courses on engineering and society. At the University of Hamburg the introduction of optional courses into all curricula allowed for the establishment of a seminar series on physics and society, as well as on peace education and peace building. Both of these approaches have a weakness in common: the courses can disappear once their initiators have left, unless the interdisciplinary themes are integrated into compulsory core curricula.

  2. EXTENDED SCHOOL YEAR DESIGNS--AN INTRODUCTION TO NEW PLANS OF SCHOOL ORGANIZATION WHICH CAN RESULT IN FINANCIAL ECONOMIES AND PROVIDE MORE EDUCATION FOR ALL PUPILS.

    Science.gov (United States)

    THOMAS, GEORGE ISAIAH

    THIS REPORT EXPLORES PLANS OF ELEMENTARY AND SECONDARY SCHOOL ORGANIZATION BASED UPON THE LENGTHENING OF THE SCHOOL YEAR TO REDUCE BY ONE OR MORE YEARS THE TOTAL PERIOD OF SCHOOLING. PRACTICAL INFORMATION IS PRESENTED CONCERNING (1) THE CONTINUOUS SCHOOL YEAR PLAN, (2) THE TRIMESTER PLAN, (3) THE QUADRIMESTER PLAN, (4) THE MODIFIED SUMMER SCHOOL…

  3. Decline of Neurologic Varicella Complications in Children During the First Seven Years After Introduction of Universal Varicella Vaccination in Germany, 2005-2011.

    Science.gov (United States)

    Streng, Andrea; Grote, Veit; Rack-Hoch, Anita; Liese, Johannes G

    2017-01-01

    Universal varicella vaccination for 1-year-old children was introduced in Germany in 2004. We investigated changes in the incidence and type of varicella-associated neurologic complications in children during the first 7 years after universal vaccination recommendation. A surveillance study was conducted based on patients linear trend across years was assessed by Poisson regression models. Of a total of 1263 varicella-associated pediatric hospitalizations, 228 children (18.1%) had neurologic complications (median age 4 years, interquartile range 2-7; 56% male). The most frequent neurologic complications were febrile convulsion (32.0% of 228 children, median age 3.0 years), varicella encephalitis or meningitis (28.9%; median age 4.5 years), syncope (13.2%; median age 7.0 years) and cerebral convulsion (11.0%; median age 4.0 years). Other complications included ataxia (3.1%), facial nerve palsy (2.6%) and cerebral vasculitis/infarction (1.8%). Neurologic complications showed a continuous decrease between 2005 and 2011, from an incidence of 2.8 (95% confidence interval: 2.1-3.6) per 100,000 children <17 years of age to 1.2 (95% confidence interval: 0.7-2.1; P < 0.001). In particular, a marked decline was observed among children up to 7 years of age, mainly because of a decrease in the number of febrile convulsions and encephalitis or meningitis. The incidence of varicella-associated neurologic complications in children decreased approximately by 60% during the first 7 years following the recommendation for universal vaccination.

  4. Introduction to modern cryptography

    CERN Document Server

    Katz, Jonathan

    2014-01-01

    Praise for the First Edition:""This book is a comprehensive, rigorous introduction to what the authors name 'modern' cryptography. … a novel approach to how cryptography is taught, replacing the older, construction-based approach. … The concepts are clearly stated, both in an intuitive fashion and formally. … I would heartily recommend this book to anyone who is interested in cryptography. … The exercises are challenging and interesting, and can benefit readers of all academic levels.""-IACR Book Reviews, January 2010""Over the past 30 years, cryptography has been transformed from a mysterious

  5. Theoretical Optics An Introduction

    CERN Document Server

    Römer, Hartmann

    2004-01-01

    Starting from basic electrodynamics, this volume provides a solid, yet concise introduction to theoretical optics, containing topics such as nonlinear optics, light-matter interaction, and modern topics in quantum optics, including entanglement, cryptography, and quantum computation. The author, with many years of experience in teaching and research, goes way beyond the scope of traditional lectures, enabling readers to keep up with the current state of knowledge. Both content and presentation make it essential reading for graduate and phD students as well as a valuable reference for researche

  6. Prevalence of 10-Year Risk of Cardiovascular Diseases and Associated Risks in Canadian Adults: The Contribution of Cardiometabolic Risk Assessment Introduction

    Directory of Open Access Journals (Sweden)

    Solmaz Setayeshgar

    2013-01-01

    Full Text Available Background. Cardiovascular disease (CVD is the leading cause of death in adult Canadians. Cardiometabolic risk (CMR derived from 10-year risk of cardiovascular diseases and metabolic syndrome (MetS needs to be evaluated in Canadian adults. Objective. To determine CMR among Canadian adults by sociodemographic and lifestyle characteristics. Subjects and Methods. Data from the Canadian Health Measures Survey (CHMS, Cycle 1, 2007–2009, was used. Framingham Risk Score (FRS was implemented to predict 10-year risk of CVD, and metabolic syndrome was identified using the most recent criteria. The 10-year risk of CVD was multiplied by 1.5 in individuals with MetS to obtain CMR. Data were weighted and bootstrapped to be able to generalize the results nationally. Results and Conclusion. CMR gave more accurate estimation of 10-year risk of CVD in Canadian adults from 30 to 74 years than using only FRS. The 10-year risk of CVD in Canadian adults significantly increased when CMR was taken into account from 8.10% to 9.86%. The CVD risk increased by increase in age, decrease in education, and decrease in physical activity and in smokers. Canadians with medium risk of CVD consumed significantly less fruit and vegetable juice compared to Canadians with low risk. No other dietary differences were found.

  7. Evaluation of the effect of the herpes zoster vaccination programme 3 years after its introduction in England: a population-based study.

    Science.gov (United States)

    Amirthalingam, Gayatri; Andrews, Nick; Keel, Philip; Mullett, David; Correa, Ana; de Lusignan, Simon; Ramsay, Mary

    2018-02-01

    In 2013, a herpes zoster vaccination programme was introduced in England for adults aged 70 years with a phased catch-up programme for those aged 71-79 years. We aimed to evaluate the effect of the first 3 years of the vaccination programme on incidence of herpes zoster and postherpetic neuralgia in this population. In this population-based study, we extracted data from the Royal College of General Practitioners sentinel primary care network on consultations with patients aged 60-89 years for herpes zoster and postherpetic neuralgia occurring between Oct 1, 2005, and Sept 30, 2016, obtaining data from 164 practices. We identified individual data on herpes zoster vaccinations administered and consultations for herpes zoster and postherpetic neuralgia, and aggregated these data to estimate vaccine coverage and incidence of herpes zoster and postherpetic neuralgia consultations. We defined age cohorts to identify participants targeted in each year of the programme, and as part of the routine or catch-up programme. We modelled incidence according to age, region, gender, time period, and vaccine eligibility using multivariable Poisson regression with an offset for person-years. Our analysis included 3·36 million person-years of data, corresponding to an average of 310 001 patients aged 60-89 years who were registered at an RCGP practice each year. By Aug 31, 2016, uptake of the vaccine varied between 58% for the recently targeted cohorts and 72% for the first routine cohort. Across the first 3 years of vaccination for the three routine cohorts, incidence of herpes zoster fell by 35% (incidence rate ratio 0·65 [95% 0·60-0·72]) and of postherpetic neuralgia fell by 50% (0·50 [0·38-0·67]). The equivalent reduction for the four catch-up cohorts was 33% for herpes zoster (incidence rate ratio 0·67 [0·61-0·74]) and 38% for postherpetic neuralgia (0·62 [0·50-0·79]). These reductions are consistent with a vaccine effectiveness of about 62% against herpes zoster

  8. An introduction to superprocesses

    CERN Document Server

    Etheridge, Alison M

    2000-01-01

    Over the past 20 years, the study of superprocesses has expanded into a major industry and can now be regarded as a central theme in modern probability theory. This book is intended as a rapid introduction to the subject, geared toward graduate students and researchers in stochastic analysis. A variety of different approaches to the superprocesses emerged over the last ten years. Yet no one approach superseded any others. In this book, readers are exposed to a number of different ways of thinking about the processes, and each is used to motivate some key results. The emphasis is on why results are true rather than on rigorous proof. Specific results are given, including extensive references to current literature for their general form.

  9. Changes in Reef Fish Abundances Associated with the Introduction of Indo-Pacific Lionfish to the Florida Keys National Marine Sanctuary: a Twenty Year Time Series.

    Science.gov (United States)

    Hepner, M.; Muller-Karger, F. E.; Gittings, S.; Stallings, C.

    2016-02-01

    The Marine Biodiversity Observation Network (MBON) is a partnership between academic, private, and government researchers seeking to understand how marine biodiversity changes over long periods of time. In this context, a study of the multi-agency Reef Visual Census (RVC) data, collected over twenty years in the Florida Keys National Marine Sanctuary (FKNMS), was analyzed to measure possible changes in reef fish abundances as a result of possible predation by lionfish predation or due to related trophic cascading. Lionfish were first sighted in the FKNMS in January 2009, with abundances and frequency of occurrence increasing three to six fold throughout the sanctuary by 2011. Their high consumption rates of smaller fish, coupled with their rapidly increasing densities may be having a significant effect on coral reef fish communities. The study compares the natural variability in reef fish abundances from 1994-2009 in the FKNMS, 15 years prior to the first lionfish detected in the sanctuary, to changes in reef fish abundances 5 years after the invasion. The MBON project also aims to develop environmental DNA (eDNA) technology for conducting biodiversity assessments. eDNA is an emerging technique that seeks to quantify biodiversity in an area by obtaining genetic material directly from environmental samples (soil, sediment, water, etc.) without any obvious signs of biological source material. All marine organisms shed DNA into their surrounding habitat, leaving a "fingerprint." Similar to forensic science, the DNA can be collected from seawater and analyzed to determine what species were recently present. The MBON team is evaluating whether eDNA can be used to adequately monitor reef fish biodiversity in coral reef ecosystems. We will compare species detected in our samples to the taxonomic composition of reef fish communities at the sample site as recorded over the past twenty years in the Reef Visual Census data.

  10. Changes in the incidence of pneumonia, bacterial meningitis, and infant mortality 5 years following introduction of the 13-valent pneumococcal conjugate vaccine in a "3+0" schedule.

    Science.gov (United States)

    Becker-Dreps, Sylvia; Blette, Bryan; Briceño, Rafaela; Alemán, Jorge; Hudgens, Michael G; Moreno, Gilberto; Ordoñez, Ana; Rocha, Julio; Weber, David J; Amaya, Erick

    2017-01-01

    Streptococcus pneumoniae causes about 826,000 deaths of children in the world each year and many health facility visits. To reduce the burden of pneumococcal disease, many nations have added pneumococcal conjugate vaccines to their national immunization schedules. Nicaragua was the first country eligible for GAVI Alliance funding to introduce the 13-valent pneumococcal conjugate vaccine (PCV13) in 2010, provided to infants at 2, 4, and 6 months of age. The goal of this study was to evaluate the population impact of the first five years of the program. Numbers of visits for pneumonia, pneumonia-related deaths, and bacterial meningitis in both children and adults, and infant deaths between 2008 and 2015 were collected from all 107 public health facilities in León Department. Vital statistics data provided additional counts of pneumonia-related deaths that occurred outside health facilities. Adjusted incidence rates and incidence rate ratios (IRRa) in the vaccine (2011-2015) and pre-vaccine periods (2008-2010) were estimated retrospectively using official population estimates as exposure time. The IRRa for pneumonia hospitalizations was 0.70 (95% confidence interval [CI]: 0.66, 0.75) for infants, and 0.92 (95% CI: 0.85, 0.99) for one year-olds. The IRRa for post-neonatal infant mortality was 0.56 (95% CI: 0.41, 0.77). In the population as a whole, ambulatory visits and hospitalizations for pneumonia, as well as pneumonia-related mortality and rates of bacterial meningitis were lower in the vaccine period. During the first five years of program implementation, reductions were observed in health facility visits for pneumonia in immunized age groups and infant mortality, which would be hard to achieve with any other single public health intervention. Future study is warranted to understand whether the lack of a booster dose (e.g., at 12 months) may be responsible for the small reductions in pneumonia hospitalizations observed in one year-olds as compared to infants.

  11. Chest wall stabilization and reconstruction: short and long-term results 5 years after the introduction of a new titanium plates system.

    Science.gov (United States)

    De Palma, Angela; Sollitto, Francesco; Loizzi, Domenico; Di Gennaro, Francesco; Scarascia, Daniele; Carlucci, Annalisa; Giudice, Giuseppe; Armenio, Andrea; Ludovico, Rossana; Loizzi, Michele

    2016-03-01

    We report short and long-term results with the dedicated Synthes(®) titanium plates system, introduced 5 years ago, for chest wall stabilization and reconstruction. We retrospectively analyzed (January 2010 to December 2014) 27 consecutive patients (22 males, 5 females; range 16-83 years, median age 60 years), treated with this system: primary [3] and secondary [8] chest wall tumor; flail chest [5]; multiple ribs fractures [5]; sternal dehiscence-diastasis [3]; sternal fracture [1]; sternoclavicular joint dislocation [1]; Poland syndrome [1]. Short-term results were evaluated as: operating time, post-operative morbidity, mortality, hospital stay; long-term results as: survival, plates-related morbidity, spirometric values, chest pain [measured with Verbal Rating Scale (VRS) and SF12 standard V1 questionnaire]. Each patient received from 1 to 10 (median 2) titanium plates/splints; median operating time was 150 min (range: 115-430 min). Post-operative course: 15 patients (55.6%) uneventful, 10 (37%) minor complications, 2 (7.4%) major complications; no post-operative mortality. Median post-operative hospital stay was 13 days (range: 5-129 days). At a median follow-up of 20 months (range: 1-59 months), 21 patients (78%) were alive, 6 (22%) died. Three patients presented long-term plates-related morbidity: plates rupture [2], pin plate dislodgment [1]; two required a second surgical look. One-year from surgery median spirometric values were: FVC 3.31 L (90%), FEV1 2.46 L (78%), DLCO 20.9 mL/mmHg/min (76%). On 21 alive patients, 7 (33.3%) reported no pain (VRS score 0), 10 (47.6%) mild (score 2), 4 (19.1%) moderate (score 4), no-one severe (score >4); 15 (71.5%) reported none or mild, 6 (28.5%) moderate pain influencing quality of life. An optimal chest wall stabilization and reconstruction was achieved with the Synthes(®) titanium plates system, with minimal morbidity, no post-operative mortality, acceptable operating time and post-operative hospital stay. Long

  12. Commentary: An Introduction to Leadership Self-Assessment at the Society of Neurological Surgeons Post-Graduate Year 1 Boot Camp: Observations and Commentary.

    Science.gov (United States)

    Hunt, Matthew A; Heilman, Carl B; Shutran, Max; Wu, Julian K

    2017-03-01

    Recent trends in graduate medical education have emphasized the mastery of nontechnical skills, especially leadership, for neurosurgical trainees. Accordingly, we introduced leadership development and self-awareness training to interns attending the Society of Neurological Surgeons Post-Graduate Year 1 Boot Camp in the Northeast (New England/New York/New Jersey) region in 2015. Feedback about the session was collected from interns. While neurosurgical interns conveyed a desire to receive more information on improving their leadership skills, most indicated that guidance seemed to be lacking in this critical area. We discuss some of the professional development needs uncovered during this process. Copyright © 2017 by the Congress of Neurological Surgeons.

  13. Introduction to IBS

    Science.gov (United States)

    ... Day Art of IBS Gallery Contact Us Search Introduction to IBS Details What is IBS? Last Updated: ... tax-deductible donation. Make Donation What is IBS? Introduction to IBS Symptoms of IBS What Causes IBS? ...

  14. Nasopharyngeal carriage of Streptococcus pneumoniae among HIV-infected and -uninfected children <5 years of age before introduction of pneumococcal conjugate vaccine in Mozambique.

    Directory of Open Access Journals (Sweden)

    Jennifer R Verani

    Full Text Available Nasopharyngeal carriage is a precursor for pneumococcal disease and can be useful for evaluating pneumococcal conjugate vaccine (PCV impact. We studied pre-PCV pneumococcal carriage among HIV-infected and -uninfected children in Mozambique. Between October 2012 and March 2013, we enrolled HIV-infected children age <5 years presenting for routine care at seven HIV clinics in 3 sites, including Maputo (urban-south, Nampula (urban-north, and Manhiça (rural-south. We also enrolled a random sample of HIV-uninfected children <5 years old from a demographic surveillance site in Manhiça. A single nasopharyngeal swab was obtained and cultured following enrichment in Todd Hewitt broth with yeast extract and rabbit serum. Pneumococcal isolates were serotyped by Quellung reaction and multiplex polymerase chain reaction. Factors associated with pneumococcal carriage were examined using logistic regression. Overall pneumococcal carriage prevalence was 80.5% (585/727, with similar prevalences among HIV-infected (81.5%, 339/416 and HIV-uninfected (79.1%, 246/311 children, and across age strata. Among HIV-infected, after adjusting for recent antibiotic use and hospitalization, there was no significant association between study site and colonization: Maputo (74.8%, 92/123, Nampula (83.7%, 82/98, Manhiça (84.6%, 165/195. Among HIV-uninfected, report of having been born to an HIV-infected mother was not associated with colonization. Among 601 pneumococcal isolates from 585 children, serotypes 19F (13.5%, 23F (13.1%, 6A (9.2%, 6B (6.2% and 19A (5.2% were most common. The proportion of serotypes included in the 10- and 13-valent vaccines was 44.9% and 61.7%, respectively, with no significant differences by HIV status or age group. Overall 36.9% (n = 268 of children were colonized with a PCV10 serotype and 49.7% (n = 361 with a PCV13 serotype. Pneumococcal carriage was common, with little variation by geographic region, age, or HIV status. PCV10 was introduced in

  15. An Introduction to ATLAS Pixel Detector DAQ and Calibration Software Based on a Year's Work at CERN for the Upgrade from 8 to 13 TeV

    CERN Document Server

    AUTHOR|(CDS)2094561

    An overview is presented of the ATLAS pixel detector Data Acquisition (DAQ) system obtained by the author during a year-long opportunity to work on calibration software for the 2015-16 Layer‑2 upgrade. It is hoped the document will function more generally as an easy entry point for future work on ATLAS pixel detector calibration systems. To begin with, the overall place of ATLAS pixel DAQ within the CERN Large Hadron Collider (LHC), the purpose of the Layer-2 upgrade and the fundamentals of pixel calibration are outlined. This is followed by a brief look at the high level structure and key features of the calibration software. The paper concludes by discussing some difficulties encountered in the upgrade project and how these led to unforeseen alternative enhancements, such as development of calibration “simulation” software allowing the soundness of the ongoing upgrade work to be verified while not all of the actual readout hardware was available for the most comprehensive testing.

  16. Introduction to Special Issue: A Review of the International Classification of Functioning, Disability and Health and Physical Therapy over the Years.

    Science.gov (United States)

    Escorpizo, Reuben; Bemis-Dougherty, Anita

    2015-12-01

    The International Classification of Functioning, Disability and Health (ICF) of the World Health Organization was developed as a common framework to understand health and to describe the impact of health condition on functioning. The purpose of this paper is to summarize the literature on the use of the ICF in physical therapy practice and research. We performed a scoping-narrative review and searched for relevant English language articles from 2001 to 2012 in multiple databases that included MEDLINE, PsycINFO, PubMed and Physiotherapy Evidence Database. Our keywords for the search consisted of ['physical therapy' OR 'physiotherapy'] AND ['ICF']. All types of articles were considered. We found 268 articles; out of which, 79 were reviewed. The years with most publications were 2011 (n = 16), 2008 (n = 15) and 2010 and 2012 (both with n = 13). Publications mostly came from the United States with 27% of the articles. The journal Physical Therapy leads with almost a third of ICF-related physical therapy publications. The ICF has been mostly used in studies of musculoskeletal and neuromuscular conditions. We found a wide array of application of the ICF in research, clinical practice and teaching (classroom and clinical education). Emerging topics included using the ICF in resource allocation and prevention and wellness. The use of the ICF in physical therapy practice and research is promising and continues to evolve. With recent developments in ICF-based measurement and integration in assessment tools for use in the clinics, research and teaching, the need to show the added value of using the ICF in practice and research remains. Copyright © 2013 John Wiley & Sons, Ltd.

  17. Italy and Austria before and after study: second-hand smoke exposure in hospitality premises before and after 2 years from the introduction of the Italian smoking ban.

    Science.gov (United States)

    Gorini, G; Moshammer, H; Sbrogiò, L; Gasparrini, A; Nebot, M; Neuberger, M; Tamang, E; Lopez, M J; Galeone, D; Serrahima, E

    2008-08-01

    The aim of this paper was to compare nicotine concentration in 28 hospitality premises (HPs) in Florence and Belluno, Italy, where a smoking ban was introduced in 2005, and in 19 HPs in Vienna, Austria, where no anti-smoking law entered into force up to now. Airborne nicotine concentrations were measured in the same HPs in winter 2002 or 2004 (pre-ban measurements) and winter 2007 (post-ban measurements). In Florence and Belluno, medians decreased significantly (P hospitality workers of 11.81 and 14.67 per 10,000, respectively. Lifetime excess lung cancer mortality risks for bar and disco-pub workers were 10-20 times higher than that calculated for restaurant workers, both in Italy and Austria. In winter 2007, it dropped to 0.01 per 10,000 in Italy, whereas in Austria it remained at the same levels. The drop of second-hand smoke exposure indicates a substantial improvement in air quality in Italian HPs even after 2 years from the ban. The nation-wide smoking ban introduced in Italy on January 10, 2005, resulted in a drop in second-hand smoke exposure in hospitality premises, whereas in Austria, where there is no similar nation-wide smoking ban, the exposure to second-hand smoke in hospitality premises remains high. Given that second-hand smoke is considered a group 1 carcinogen according to the International Agency for Research on Cancer classification, the World Health Organization Framework Convention on Tobacco Control strongly recommends the implementation of nation-wide smoke-free policies in order to improve the indoor air quality of hospitality premises and workplaces. Results from our study strongly supports this recommendation.

  18. Staff perceptions of addressing lifestyle in primary health care: a qualitative evaluation 2 years after the introduction of a lifestyle intervention tool

    Directory of Open Access Journals (Sweden)

    Carlfjord Siw

    2012-10-01

    Full Text Available Abstract Background Preventive services and health promotion in terms of lifestyle counselling provided through primary health care (PHC has the potential to reduce morbidity and mortality in the population. Health professionals in general are positive about and willing to develop a health-promoting and/or preventive role. A number of obstacles hindering PHC staff from addressing lifestyle issues have been identified, and one facilitator is the use of modern technology. When a computer-based tool for lifestyle intervention (CLT was introduced at a number of PHC units in Sweden, this provided an opportunity to study staff perspectives on the subject. The aim of this study was to explore PHC staff’s perceptions of handling lifestyle issues, including the consultation situation as well as the perceived usefulness of the CLT. Methods A qualitative study was conducted after the CLT had been in operation for 2 years. Six focus group interviews, one at each participating unit, including a total of 30 staff members with different professions participated. The interviews were designed to capture perceptions of addressing lifestyle issues, and of using the CLT. Interview data were analysed using manifest content analysis. Results Two main themes emerged from the interviews: a challenging task and confidence in handling lifestyle issues. The first theme covered the categories responsibilities and emotions, and the second theme covered the categories first contact, existing tools, and role of the CLT. Staff at the units showed commitment to health promotion/prevention, and saw that patients, caregivers, managers and politicians all have responsibilities regarding the issue. They expressed confidence in handling lifestyle-related conditions, but to a lesser extent had routines for general screening of lifestyle habits, and found addressing alcohol the most problematic issue. The CLT, intended to facilitate screening, was viewed as a complement, but was not

  19. Morbillivirus Infections: An Introduction

    Directory of Open Access Journals (Sweden)

    Rory D. de Vries

    2015-02-01

    Full Text Available Research on morbillivirus infections has led to exciting developments in recent years. Global measles vaccination coverage has increased, resulting in a significant reduction in measles mortality. In 2011 rinderpest virus was declared globally eradicated – only the second virus to be eradicated by targeted vaccination. Identification of new cellular receptors and implementation of recombinant viruses expressing fluorescent proteins in a range of model systems have provided fundamental new insights into the pathogenesis of morbilliviruses, and their interactions with the host immune system. Nevertheless, both new and well-studied morbilliviruses are associated with significant disease in wildlife and domestic animals. This illustrates the need for robust surveillance and a strategic focus on barriers that restrict cross-species transmission. Recent and ongoing measles outbreaks also demonstrate that maintenance of high vaccination coverage for these highly infectious agents is critical. This introduction briefly summarizes the most important current research topics in this field.

  20. Introduction to thermoelectricity

    CERN Document Server

    Goldsmid, H Julian

    2016-01-01

    This book is a comprehensive introduction to all aspects of thermoelectric energy conversion. It covers both theory and practice. The book is timely as it refers to the many improvements that have come about in the last few years through the use of nanostructures. The concept of semiconductor thermoelements led to major advances during the second half of the twentieth century, making Peltier refrigeration a widely used technique. The latest materials herald thermoelectric generation as the preferred technique for exploiting low-grade heat. The book shows how progress has been made by increasing the thermal resistivity of the lattice until it is almost as large as it is for glass. It points the way towards the attainment of similar improvements in the electronic parameters. It does not neglect practical considerations, such as the desirability of making thermocouples from inexpensive and environmentally acceptable materials. The second edition was extended to also include recent advances in thermoelectric ener...

  1. Introduction to thermoelectricity

    CERN Document Server

    Goldsmid, H Julian

    2010-01-01

    Introduction to Thermoelectricity is the latest work by Professor Julian Goldsmid drawing on his 55 years experience in the field. The theory of the thermoelectric and related phenomena is presented in sufficient detail to enable researchers to understand their observations and develop improved thermoelectric materials. The methods for the selection of materials and their improvement are discussed. Thermoelectric materials for use in refrigeration and electrical generation are reviewed. Experimental techniques for the measurement of properties and for the production of thermoelements are described. Special emphasis is placed on nanotechnology which promises to yield great improvements in the efficiency of thermoelectric devices. Chapters are also devoted to transverse thermoelectric effects and thermionic energy conversion, both techniques offering the promise of important applications in the future.

  2. Introduction to variance estimation

    CERN Document Server

    Wolter, Kirk M

    2007-01-01

    We live in the information age. Statistical surveys are used every day to determine or evaluate public policy and to make important business decisions. Correct methods for computing the precision of the survey data and for making inferences to the target population are absolutely essential to sound decision making. Now in its second edition, Introduction to Variance Estimation has for more than twenty years provided the definitive account of the theory and methods for correct precision calculations and inference, including examples of modern, complex surveys in which the methods have been used successfully. The book provides instruction on the methods that are vital to data-driven decision making in business, government, and academe. It will appeal to survey statisticians and other scientists engaged in the planning and conduct of survey research, and to those analyzing survey data and charged with extracting compelling information from such data. It will appeal to graduate students and university faculty who...

  3. Intermedia transfer factors for fifteen toxic pollutants released to air basins in California

    Energy Technology Data Exchange (ETDEWEB)

    McKone, T.E.; Daniels, J.I. [Lawrence Livermore National Lab., CA (United States); Chiao, F.F.; Hsieh, D.P.H. [Univ. of California, Davis, CA (United States)

    1993-10-01

    This report provides a summary definition of the intermedia-transfer factors (ITFs). Methods are discussed for estimating these parameters in the absence of measured values, and the estimation errors inherent in these estimation methods are considered. A detailed summary is provided of measured and estimated ITF values for fifteen air contaminants. They include: 1,3 butadiene; cadmium; cellosolve; cellosolve acetate; chloroform; di-2-ethylhexylphthalate; 1,4-dioxame; hexachlorobenzene; inorganic arsenic; inorganic lead; nickel; tetrachloroethylene; toluene; toluene-2,4-diisocyanate; and 1,3-xylene. Recommendations are made regarding the expected value and variance in these values for use in exposure models.

  4. Introduction to applied algebraic systems

    CERN Document Server

    Reilly, Norman R

    2009-01-01

    This upper-level undergraduate textbook provides a modern view of algebra with an eye to new applications that have arisen in recent years. A rigorous introduction to basic number theory, rings, fields, polynomial theory, groups, algebraic geometry and elliptic curves prepares students for exploring their practical applications related to storing, securing, retrieving and communicating information in the electronic world. It will serve as a textbook for an undergraduate course in algebra with a strong emphasis on applications. The book offers a brief introduction to elementary number theory as

  5. An introduction to fire dynamics

    CERN Document Server

    Drysdale, Dougal

    2011-01-01

    "Drysdale's book is by far the most comprehensive - everyone in the office has a copy...now including me. It holds just about everything you need to know about fire science."(Review of An Introduction to Fire Dynamics, 2nd Edition) After 25 years as a bestseller, Dougal Drysdale's classic introduction has been brought up-to-date and expanded to incorporate the latest research and experimental data.  Homework problems are included, with solutions, and others are available on the accompanying website at www.wiley.com/go/drysdale. Essential reading for all involved in the field from undergraduate

  6. WE-B-210-01: Introduction

    International Nuclear Information System (INIS)

    Holland, M.

    2015-01-01

    In the last fifteen years, the introduction of plane or diverging wave transmissions rather than line by line scanning focused beams has broken the conventional barriers of ultrasound imaging. By using such large field of view transmissions, the frame rate reaches the theoretical limit of physics dictated by the ultrasound speed and an ultrasonic map can be provided typically in tens of micro-seconds (several thousands of frames per second). Interestingly, this leap in frame rate is not only a technological breakthrough but it permits the advent of completely new ultrasound imaging modes, including shear wave elastography, electromechanical wave imaging, ultrafast doppler, ultrafast contrast imaging, and even functional ultrasound imaging of brain activity (fUltrasound) introducing Ultrasound as an emerging full-fledged neuroimaging modality. At ultrafast frame rates, it becomes possible to track in real time the transient vibrations – known as shear waves – propagating through organs. Such “human body seismology” provides quantitative maps of local tissue stiffness whose added value for diagnosis has been recently demonstrated in many fields of radiology (breast, prostate and liver cancer, cardiovascular imaging, …). Today, Supersonic Imagine company is commercializing the first clinical ultrafast ultrasound scanner, Aixplorer with real time Shear Wave Elastography. This is the first example of an ultrafast Ultrasound approach surpassing the research phase and now widely spread in the clinical medical ultrasound community with an installed base of more than 1000 Aixplorer systems in 54 countries worldwide. For blood flow imaging, ultrafast Doppler permits high-precision characterization of complex vascular and cardiac flows. It also gives ultrasound the ability to detect very subtle blood flow in very small vessels. In the brain, such ultrasensitive Doppler paves the way for fUltrasound (functional ultrasound imaging) of brain activity with unprecedented

  7. WE-B-210-01: Introduction

    Energy Technology Data Exchange (ETDEWEB)

    Holland, M. [Indiana University-School of Medicine (United States)

    2015-06-15

    In the last fifteen years, the introduction of plane or diverging wave transmissions rather than line by line scanning focused beams has broken the conventional barriers of ultrasound imaging. By using such large field of view transmissions, the frame rate reaches the theoretical limit of physics dictated by the ultrasound speed and an ultrasonic map can be provided typically in tens of micro-seconds (several thousands of frames per second). Interestingly, this leap in frame rate is not only a technological breakthrough but it permits the advent of completely new ultrasound imaging modes, including shear wave elastography, electromechanical wave imaging, ultrafast doppler, ultrafast contrast imaging, and even functional ultrasound imaging of brain activity (fUltrasound) introducing Ultrasound as an emerging full-fledged neuroimaging modality. At ultrafast frame rates, it becomes possible to track in real time the transient vibrations – known as shear waves – propagating through organs. Such “human body seismology” provides quantitative maps of local tissue stiffness whose added value for diagnosis has been recently demonstrated in many fields of radiology (breast, prostate and liver cancer, cardiovascular imaging, …). Today, Supersonic Imagine company is commercializing the first clinical ultrafast ultrasound scanner, Aixplorer with real time Shear Wave Elastography. This is the first example of an ultrafast Ultrasound approach surpassing the research phase and now widely spread in the clinical medical ultrasound community with an installed base of more than 1000 Aixplorer systems in 54 countries worldwide. For blood flow imaging, ultrafast Doppler permits high-precision characterization of complex vascular and cardiac flows. It also gives ultrasound the ability to detect very subtle blood flow in very small vessels. In the brain, such ultrasensitive Doppler paves the way for fUltrasound (functional ultrasound imaging) of brain activity with unprecedented

  8. Introduction to graph theory

    CERN Document Server

    Trudeau, Richard J

    1994-01-01

    Preface1. Pure Mathematics Introduction; Euclidean Geometry as Pure Mathematics; Games; Why Study Pure Mathematics?; What's Coming; Suggested Reading2. Graphs Introduction; Sets; Paradox; Graphs; Graph diagrams; Cautions; Common Graphs; Discovery; Complements and Subgraphs; Isomorphism; Recognizing Isomorphic Graphs; Semantics The Number of Graphs Having a Given nu; Exercises; Suggested Reading3. Planar Graphs Introduction; UG, K subscript 5, and the Jordan Curve Theorem; Are there More Nonplanar Graphs?; Expansions; Kuratowski's Theorem; Determining Whether a Graph is Planar or

  9. Bayesian Networks An Introduction

    CERN Document Server

    Koski, Timo

    2009-01-01

    Bayesian Networks: An Introduction provides a self-contained introduction to the theory and applications of Bayesian networks, a topic of interest and importance for statisticians, computer scientists and those involved in modelling complex data sets. The material has been extensively tested in classroom teaching and assumes a basic knowledge of probability, statistics and mathematics. All notions are carefully explained and feature exercises throughout. Features include:.: An introduction to Dirichlet Distribution, Exponential Families and their applications.; A detailed description of learni

  10. Introduction to clinical nutrition

    National Research Council Canada - National Science Library

    Sardesai, Vishwanath M

    2012-01-01

    .... Introduction to Clinical Nutrition, Third edition discusses the physiologic and metabolic interrelationships of all nutrients and their roles in health maintenance and the prevention of various...

  11. Chief Editors’ Introduction

    Directory of Open Access Journals (Sweden)

    Kerry Carrington

    2015-12-01

    Full Text Available It has been a great year for the journal:  our most successful ever. This edition marks three years of publication of the International Journal for Crime, Justice and Social Democracy. In 2015 the journal was selected for inclusion into Scopus and Web of Science data bases. This is a terrific success story and testimony to the high quality of the articles, the editorship, the reviewing and the international readership of the journal. We are grateful as ever to our distinguished International Editorial Board and all our reviewers who are anonymous to readers and authors due to the norms of blind peer reviewing. We also thank the out-going foundational co-editor-in-chief Reece Walters for his efforts in making this journal the success it is. The journal has now surpassed 150,000 abstract views and 100,000 full PDF downloads. This journal is one of only a few in the world of criminology to support fully on-line free-to-download articles, and to promote creative commons copyright: that is, authors’ rights to reproduce their own material. We support the democratisation of knowledge and are delighted to be leaders in high quality international journal publishing.Download the PDF file here for the Chief Editors’ introduction to this issue and be motivated by the eclectic and impressive range of topics offered by our contributors to read further.

  12. Developmental profiles on the basis of the FTF (Five to Fifteen) questionnaire

    DEFF Research Database (Denmark)

    Trillingsgaard, Anegen; Damm, Dorte; Sommer, Søren

    2004-01-01

    , memory, language, social skills and learning, in addition to a domain for emotional and behavioural problems. The aim of the present study was to test the clinical validity and utility of the FTF with a main focus on discriminant and criterion validity. The clinical sample consisted of 155 clinically...... to fifteen. Results demonstrated that the profiles for the clinical groups were similar in forms and levels to those of the upper 10 percent of the norm sample (those with most difficulties). Five out of eight FTF domains discriminated significantly between diagnostic groups in the clinical sample. Influence...... of IQ, gender and age on the results were low. Three out of four relevant FTF domains correlated significantly with corresponding WISC-III indexes/measures. The clinical utility of individual children's profiles were demonstrated. On the whole, the findings supported the clinical validity and utility...

  13. Incidence of invasive pneumococcal disease in 5-15 year old children with and without comorbidities in Germany after the introduction of PCV13: Implications for vaccinating children with comorbidities.

    Science.gov (United States)

    Weinberger, Raphael; Falkenhorst, Gerhard; Bogdan, Christian; van der Linden, Mark; Imöhl, Matthias; von Kries, Rüdiger

    2015-11-27

    To describe the burden of suffering from IPD in children aged 5-15 years with and without comorbidities up to 5 years after the introduction of PCV13 in Germany and to identify the potential benefit for PCV13 and PPV23 vaccination. The surveillance of IPD for children children from 2010 to 2014 in Germany. Incidence was estimated by capture-recapture analysis with stratification by absence/presence of comorbidities. Coverage of the observed serotypes by different vaccines was assessed. 142 (Capture recapture-corrected: 437) cases were reported: 72.5% were healthy children and 27.5% had a comorbidity. The incidence of IPD related to children with comorbidities was 0.2 per 100,000. One third of these cases had serotypes not included in either vaccine. The remaining cases might benefit from pneumococcal vaccination but one third of all cases was not vaccinated. The additional potential benefit of PPV23 compared to PCV13 with respect to coverage was 10%. The incidence of IPD in children with comorbidities in Germany is low. Pneumococcal vaccination uptake in children with comorbidities should be increased, although only about two-thirds of the cases might be preventable by presently available vaccines. Copyright © 2015 Elsevier Ltd. All rights reserved.

  14. Introduction to surveillance studies

    CERN Document Server

    Petersen, JK

    2012-01-01

    Introduction & OverviewIntroduction Brief History of Surveillance Technologies & TechniquesOptical SurveillanceAerial Surveillance Audio Surveillance Radio-Wave SurveillanceGlobal Positioning Systems Sensors Computers & the Internet Data Cards Biochemical Surveillance Animal Surveillance Biometrics Genetics Practical ConsiderationsPrevalence of Surveillance Effectiveness of Surveillance Freedom & Privacy IssuesConstitutional Freedoms Privacy Safeguards & Intrusions ResourcesReferences Glossary Index

  15. Introduction to Part 3

    DEFF Research Database (Denmark)

    Petersen, Nils Holger

    2015-01-01

    A brief contextualising discussion of Western Music History and its relations to Theological Aesthetical Thought since Carolingian Times as an introduction to 3 music articles in Part 3 of the volume.......A brief contextualising discussion of Western Music History and its relations to Theological Aesthetical Thought since Carolingian Times as an introduction to 3 music articles in Part 3 of the volume....

  16. Environmental Psychology: An Introduction

    NARCIS (Netherlands)

    Steg, L.; Berg, van den A.E.; Groot, de J.I.M.

    2012-01-01

    Environmental Psychology: An Introduction offers a research-based introduction to the psychological relationship between humans and their built and natural environments and discusses how sustainable environments can be created to the benefit of both people and nature •Explores the environment's

  17. ONE HUNDRED YEARS OF MILES’ OPERATION- WHAT HAS CHANGED?

    Directory of Open Access Journals (Sweden)

    Vanja Pecić

    2008-12-01

    Full Text Available Lisfranc was probably the first to excise the rectum for cancer. He performed operation using perineal approach in 1826. This operation came into common use fifty years later. Czerny did the first combined abdominoperineal resection in attempt to finish excision he could not complete from below. Some fifteen years later Ernest Miles described the planned, one stage abdominoperineal resection.Miles name has become a synonym for this combined procedure, creating a radical change in the philosophy of resection and en bloc lymphadenectomy.In the beginning of twenty-century abdominoperineal resection became golden standard in the treatment of rectal cancer. Reconstructive operations, introduction of stapling devices and better understanding of potential tumor spread, reduced indications for Miles operation.Surgical treatment of rectal cancer made progress in the past 100 years. Miles was the first in line. Without his theory of perirectal lymphatic spread recurrence rate would be still as high as 95%.

  18. Evolutionary genetics: 150 years of natural selection

    Indian Academy of Sciences (India)

    This year marks a hundred and fifty years since the formal enunciation of the ... publication of R. A. Fisher's landmark paper reconciling the statistical results of the ... applications of evolutionary thinking that has emerged over the past fifteen.

  19. Introduction to industrial radiography

    International Nuclear Information System (INIS)

    Abdul Nassir Ibrahim; Azali Muhammad; Ab. Razak Hamzah; Abd. Aziz Mohamed; Mohamad Pauzi Ismail

    2008-01-01

    For the first topic in this book, more on introduction to nondestructive testing, also a little bit on another technique such as magnetic testing, liquid penetrated, ultrasonic testing and others. This book mentions more on radiographic testing and for that, more details on this topic such as history, definition and devices that use in this technique. This radiography testing firstly started with the discovering of x-ray by Wilhelm Roentgen (1895). So, on 1913, David Coolidge successfully invented and developed x-ray tube that could made x-ray more intensified and produced highly penetration forces. Radiography in Malaysia firstly started two years after the discovery made by Wilhelm Roentgen when one hospital here used the x-ray machine for medical purposes. Besides using x-ray, radiography also used gamma rays, and for these purpose, they used Co-60 and Ir-192. Now, more company based on NDT established to provide a service on inspection pipe and others. For filled these requirement, radiographer must take an exam to make them expert and trained well to work in this field. There is no advantage using this technique or other technique. So that's why this book was published to make people understand what is radiographic testing truly.

  20. Introduction - Chadwick discovers the neutron

    International Nuclear Information System (INIS)

    Hendry, J.

    1984-01-01

    The background to Chadwick's discovery in 1932 of the neutron predicted by Rutherford is chronicled. In the same year Cockcroft and Walton split the atom, and the story of this event is told. 1932 also saw the demonstration by Blackett and Occhialini of the existence of the positron. These important contributions to nuclear physics were all made at the Cavendish Laboratory in Cambridge. Photographs, extracts from experimental notebooks and circuit diagrams illustrate this introduction. (UK)

  1. An introduction to computational micromechanics

    CERN Document Server

    Zohdi, Tarek I; Zohdi, Tarek I

    2004-01-01

    In this, its second corrected printing, Zohdi and Wriggers' illuminating text presents a comprehensive introduction to the subject. The authors include in their scope basic homogenization theory, microstructural optimization and multifield analysis of heterogeneous materials. This volume is ideal for researchers and engineers, and can be used in a first-year course for graduate students with an interest in the computational micromechanical analysis of new materials.

  2. Assessing the effects of vegetation types on carbon storage fifteen years after reforestation on a Chinese fir site

    Science.gov (United States)

    Qinkui Wang; Silong Wang; Jianwei Zhang

    2009-01-01

    Forest ecosystems play a significant role in sequestering carbon (C) in biomass and soils. Plantations established in subtropical China since the 1980s, mainly of Chinese fir (Cunninghamia lanceolata (Lamb.) Hook) in monocultures, have proved to be major C sinks. However, information is lacking about whether mixing Chinese fir with broadleaved tree...

  3. The leaching of radioactivity from highly radioactive glass blocks buried below the water table: fifteen years of results

    International Nuclear Information System (INIS)

    Merritt, W.F.

    1976-03-01

    The results from two test burials of high-level fission products incorporated into nepheline syenite glass indicate that the nuclear wastes from fuel processing for a 30,000 MWe nuclear power industry could be incorporated into such glass and stored beneath the water table in the waste management area of Chalk River Nuclear Laboratories (CRNL) without harm to the environment. (author)

  4. Update on best available options in obstetrics anaesthesia: perinatal outcomes, side effects and maternal satisfaction. Fifteen years systematic literature review.

    Science.gov (United States)

    Gizzo, Salvatore; Noventa, Marco; Fagherazzi, Simone; Lamparelli, Laura; Ancona, Emanuele; Di Gangi, Stefania; Saccardi, Carlo; D'Antona, Donato; Nardelli, Giovanni Battista

    2014-07-01

    In modern obstetrics, different pharmacological and non-pharmacological options allow to obtain pain relief during labour, one of the most important goals in women satisfaction about medical care. The aim of this review is to compare all the analgesia administration schemes in terms of effectiveness in pain relief, length of labour, mode of delivery, side effects and neonatal outcomes. A systematic literature search was conducted in electronic databases in the interval time between January 1999 and March 2013. Key search terms included: “labour analgesia”, “epidural anaesthesia during labour” (excluding anaesthesia for Caesarean section), “epidural analgesia and labour outcome” and “intra-thecal analgesia”. 10,331 patients were analysed: 5,578 patients underwent Epidural-Analgesia, 259 patients spinal analgesia, 2,724 combined spinal epidural analgesia, 322 continuous epidural infusion (CEI), 168 intermittent epidural bolus, 684 patient-controlled infusion epidural analgesia and 152 intra-venous patient-controlled epidural analgesia. We also considered 341 women who underwent patient-controlled infusion epidural analgesia in association with CEI and 103 patients who underwent patient-controlled infusion epidural analgesia in association with automatic mandatory bolus. No significant differences occurred among all the available administration schemes of neuraxial analgesia. In absence of obstetrical contraindication, neuraxial analgesia has to be considered as the gold standard in obtaining maternal pain relief during labour. The options available in the administration of analgesia should be known and evaluated together by both gynaecologists and anaesthesiologists to choose the best personalized scheme and obtain the best women satisfaction. Since it is difficult to identify comparable circumstances during labour, it is complicate to standardize drugs schemes and their combinations.

  5. Fifteen-year follow-up of pulmonary function in individuals heterozygous for the cystic fibrosis phenylalanine-508 deletion

    DEFF Research Database (Denmark)

    Dahl, Morten; Nordestgaard, B G; Lange, P

    2001-01-01

    In a cross-sectional study, we previously showed that cystic fibrosis phenylalanine-508 deletion (DeltaF508) heterozygosity may be overrepresented among individuals with asthma.......In a cross-sectional study, we previously showed that cystic fibrosis phenylalanine-508 deletion (DeltaF508) heterozygosity may be overrepresented among individuals with asthma....

  6. PREFACE: The First Fifteen Years of Reverse Monte Carlo Modelling, Budapest, Hungary (9--11 October 2003)

    Science.gov (United States)

    Keen, David A.; Pusztai, Laszlo; Dove, Martin T.

    2005-02-01

    This special issue contains a collection of papers reflecting the content of the second workshop on reverse Monte Carlo (RMC) methods, held in a hotel on hills overlooking Budapest in October 2003. Around forty participants gathered to hear talks and discuss a broad range of science based on the RMC technique in very convivial surroundings. Reverse Monte Carlo modelling is a method for producing three-dimensional disordered structural models in quantitative agreement with experimental data. The method was developed in the late 1980’s and has since achieved wide acceptance within the scientific community. It is particularly suitable for studies of the structures of liquid and amorphous materials, although it has also been used for a number of disordered crystalline systems. There is currently a great interest in the properties of disordered materials and this has produced a resurgence in methods for investigating their structures, with an increased number of high-quality instruments at central facilities for neutron and x-ray scattering from disordered materials. Methods such as RMC are currently in great demand for analysing the resulting total scattering and XAS data and the RMC methodology is actively being developed by a number of groups worldwide. Within this context, the RMC workshop was particularly timely, providing a forum for those workers in the field to take stock of past achievements and to look forward to future developments. It is our hope that the collection of papers within this special issue will also communicate this to the wider scientific community, by providing a balance between papers that have more of an introductory review flavour and those that concentrate on current state of the art research opportunities using the RMC method. The order of the papers within this special issue reflects this balance. The first two papers are introductory reviews of the RMC method in general and as applied specifically to crystalline systems, respectively. The next, largest group describes a wide range of scientific applications of the RMC method within liquid, amorphous, crystalline and nanocrystalline materials. The final group of papers have a bias towards method development and testing, particularly with regard to the use of XAS data in RMC modelling. We are very grateful to Institute of Physics Publishing for their willingness to publish the proceedings of this meeting in a special issue of Journal of Physics: Condensed Matter.

  7. A comprehensive literature review reflecting fifteen years of debate regarding the representativity of reverse circulation vs blast hole drill sampling

    DEFF Research Database (Denmark)

    Engström, Karin

    2017-01-01

    Blast hole sampling is widely used for grade control by the mining industry all over the world, both in precious and base metal open pit mining. Blast hole (BH) samples are often regarded as inferior in comparison to “proper drill sampling” like reverse circulation (RC) and diamond (core) drilling...... (DD), and are accused of lacking representativity by the sampling community. The present paper aims at collecting all peer reviewed publications from 2000 onwards that concern open pit mine sampling performance of BH, RC and/or DD drill sampling. This will form a comprehensive literature review...

  8. Remembrances of the early fifteen years of radiation protection at the National Atomic Energy Commission. Part 2

    International Nuclear Information System (INIS)

    Placer, Alejandro E.

    2005-01-01

    Personal memories on the origin of radiation protection activities in Argentina. This second part covers the period from 1957 to the early sixties and describes the persons and facts that led to the future development of radiation protection in the country [es

  9. Remembrances of the early fifteen years of radiation protection at the National Atomic Energy Commission. Part 3

    International Nuclear Information System (INIS)

    Placer, Alejandro E.

    2005-01-01

    Personal memories on the origin of radiation protection activities in Argentina. This third part covers the period from 1963 to 1973 and describes the persons and facts that led to the future development of radiation protection in the country [es

  10. Fifteen-year follow-up of a patient with beta thalassaemia and extramedullary haematopoietic tissue compressing the spinal cord

    Energy Technology Data Exchange (ETDEWEB)

    Niggemann, P.; Krings, T.; Thron, A. [Dept. of Neuroradiology, RWTH-Aachen Hosital (Germany); Hans, F. [Dept. of Neurosurgery, RWTH Aachen Hospital (Germany); 1

    2005-04-01

    A long-term follow-up of a patient with beta thalassaemia with intra- and extraspinal extramedullary haematopoietic tissue compressing the spinal cord is presented. Extramedullary haematopoietic nodules are a rare cause of spinal cord compression and should be included in the differential diagnosis, especially in patients from Mediterranean countries. Treatment with radiation therapy solely failed, giving rise to the need of surgical intervention. Surgical decompression of the spine and the removal of the culprit lesion compressing the spine were performed. Postinterventional radiation therapy was applied to the spine. A relapse had to be treated again by surgical means combined with postinterventional radiation therapy. A complete relief of the symptoms and control of the lesion could be obtained.

  11. Fifteen-year follow-up of a patient with beta thalassaemia and extramedullary haematopoietic tissue compressing the spinal cord

    International Nuclear Information System (INIS)

    Niggemann, P.; Krings, T.; Thron, A.; Hans, F.

    2005-01-01

    A long-term follow-up of a patient with beta thalassaemia with intra- and extraspinal extramedullary haematopoietic tissue compressing the spinal cord is presented. Extramedullary haematopoietic nodules are a rare cause of spinal cord compression and should be included in the differential diagnosis, especially in patients from Mediterranean countries. Treatment with radiation therapy solely failed, giving rise to the need of surgical intervention. Surgical decompression of the spine and the removal of the culprit lesion compressing the spine were performed. Postinterventional radiation therapy was applied to the spine. A relapse had to be treated again by surgical means combined with postinterventional radiation therapy. A complete relief of the symptoms and control of the lesion could be obtained

  12. An Analysis of the First Fifteen Years of the Department of Defense Framework for Unmanned Ground Systems

    Science.gov (United States)

    2014-12-01

    1995 ..............................................78  g.  JAUGS 1995 ............................................................................82  h...108  g.  JAUGS from 1995 to 1996 ....................................................111  h.  Conclusion...2001 .......................................172  j.  JAUGS 2001 ..........................................................................173  k

  13. Fate and Effects of Crude Oil Spilled on Subarctic Permafrost Terrain in Interior Alaska: Fifteen Years Later

    Science.gov (United States)

    1993-08-01

    areas. The soil is cold and wet, a Histic downslope movement of the oil past the last Pergelic Cryaquept (Rieger 1983), typical of the Sau- mapped...histic pergelic cryaquept soil. mosses, lichens and shrubs were killed soon after have even flourished (Fig. 11). Most of the associat- the original

  14. Introduction to renewable energy

    CERN Document Server

    Nelson, Vaughn C

    2011-01-01

    IntroductionEnergy and SocietyTypes of EnergyRenewable EnergyAdvantages/DisadvantagesEconomicsGlobal WarmingOrder of Magnitude EstimatesGrowth (Exponential)SolutionsEnergyIntroductionDefinition of Energy and PowerHeatThermodynamicsEnergy Dilemma in Light of the Laws of ThermodynamicsUse of Fossil FuelsNuclearFinite ResourceSummarySunSolar PowerElectromagnetic SpectrumEnergy Balance of the EarthEarth-Sun MotionInsolationSolar ResourceGreenhouse EffectHeat Transfer and StorageIntroductionConductionConvectionRadiationThermal MassSeasonal Heating or CoolingThermal ComfortSolar Heating and CoolingB

  15. Introduction to quantum mechanics

    CERN Document Server

    Phillips, A C

    2003-01-01

    Introduction to Quantum Mechanics is an introduction to the power and elegance of quantum mechanics. Assuming little in the way of prior knowledge, quantum concepts are carefully and precisely presented, and explored through numerous applications and problems. Some of the more challenging aspects that are essential for a modern appreciation of the subject have been included, but are introduced and developed in the simplest way possible.Undergraduates taking a first course on quantum mechanics will find this text an invaluable introduction to the field and help prepare them for more adv

  16. Introduction to Pulmonary Fibrosis

    Science.gov (United States)

    ... page: Introduction to Pulmonary Fibrosis What Is Pulmonary Fibrosis? Pulmonary fibrosis is a disease where there is scarring ... of pulmonary fibrosis. Learn more How Is Pulmonary Fibrosis Diagnosed? Pulmonary fibrosis can be difficult to diagnose, so it ...

  17. MOOC Introduction to Dutch

    NARCIS (Netherlands)

    den Hollander, Franciscus; Piersma, Kristien

    Interview met Margriet Hidding, Birgit Lijmbach en Jeroen van Engen, medewerkers van het Talencentrum en de makers van de Massive Open Online Course (MOOC) Introduction to Dutch over het grote succes van deze cursus

  18. Radiation Protection: introduction

    International Nuclear Information System (INIS)

    Loos, M.

    2005-01-01

    The abstract gives an overview and introduction to the activities of SCK-CEN's Radiation Protection department. Main strategic developments and achievements in the field of life sciences, policy supports and medical applications are summarised

  19. Introduction: Ideologies of Youth

    African Journals Online (AJOL)

    seriane.camara

    2011-12-01

    Dec 1, 2011 ... target all age groups in their youth-oriented programmes. If the donor- ... van Dijk, de Bruijn, Cardoso, Butter: Introduction – Ideologies of Youth ...... Toward a Theory of Vital Conjunctures', American Anthropologist, vol. 104,.

  20. Complex Systems: An Introduction

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 14; Issue 9. Complex Systems: An Introduction - Anthropic Principle, Terrestrial Complexity, Complex Materials. V K Wadhawan. General Article Volume 14 Issue 9 September 2009 pp 894-906 ...

  1. Introduction: perspectives on Porter

    NARCIS (Netherlands)

    F.A.J. van den Bosch (Frans)

    1997-01-01

    textabstractIntroduction. Relevance of Strategy research: focus on Michael Porter's contributions Strategy is a fascinating field of enquiry, both for managers looking for a sustainable competitive advantage and for academic researchers looking for the reasons behind superior firm performance.

  2. Introduction to graph theory

    CERN Document Server

    Wilson, Robin J

    1985-01-01

    Graph Theory has recently emerged as a subject in its own right, as well as being an important mathematical tool in such diverse subjects as operational research, chemistry, sociology and genetics. This book provides a comprehensive introduction to the subject.

  3. Introduction to numerical analysis

    CERN Document Server

    Hildebrand, F B

    1987-01-01

    Well-known, respected introduction, updated to integrate concepts and procedures associated with computers. Computation, approximation, interpolation, numerical differentiation and integration, smoothing of data, other topics in lucid presentation. Includes 150 additional problems in this edition. Bibliography.

  4. Prevalence of trachoma in school children in the Marajó Archipelago, Brazilian Amazon, and the impact of the introduction of educational and preventive measures on the disease over eight years.

    Directory of Open Access Journals (Sweden)

    Joana Favacho

    2018-02-01

    Full Text Available Trachoma is the leading infectious cause of blindness in the world and is associated with precarious living conditions in developing countries. The aim of the present study was to evaluate the prevalence of trachoma in three municipalities of the Marajó Archipelago, located in the state of Pará, Brazil. In 2008, 2,054 schoolchildren from the public primary school system of the urban area of the region and their communicants were clinically examined; in 2016, 1,502 schoolchildren were examined. The positive cases seen during the clinical evaluation were confirmed by direct immunofluorescence (DIF laboratory tests. The presence of antibodies against the genus Chlamydia was evaluated by indirect immunofluorescence (IIF, and the serotypes were determined by microimmunofluorescence (MIF. In 2008, the prevalence of trachoma among schoolchildren was 3.4% (69 cases and it was more frequent in children between six and nine years of age and in females; among the communicants, a prevalence of 16.5% was observed. In 2016, three cases of trachoma were diagnosed (prevalence of 0.2%, found only in the municipality of Soure. The results of the present study showed that in 2008, trachoma had a low prevalence (3.4% among schoolchildren in the urban area of Marajó Archipelago; eight years after the first evaluation and the introduction of control and prevention measures (SAFE strategy, there was a drastic reduction in the number of cases (0.2%, demonstrating the need for constant monitoring and effective measures for the elimination of trachoma.

  5. General introduction to glucosinolates

    DEFF Research Database (Denmark)

    Halkier, Barbara Ann

    2016-01-01

    will be presented a general introduction to glucosinolates ranging from the evolution of glucosinolates to the many roles glucosinolates have for humans as well as an overview of the current knowledge on the orchestration of the glucosinolate biosynthetic pathway. The latter includes an introduction to the genes...... to the plasma membrane. Examples of how the knowledge gained from basic research has been translated into applied glucosinolate research through pathway and transport engineering will be presented....

  6. Stochastic processes an introduction

    CERN Document Server

    Jones, Peter Watts

    2009-01-01

    Some Background on ProbabilityIntroduction Probability Conditional probability and independence Discrete random variables Continuous random variables Mean and variance Some standard discrete probability distributions Some standard continuous probability distributions Generating functions Conditional expectationSome Gambling ProblemsGambler's ruin Probability of ruin Some numerical simulations Duration of the game Some variations of gambler's ruinRandom WalksIntroduction Unrestricted random walks The probability distribution after n steps First returns of the symmetric random walkMarkov ChainsS

  7. Introduction to elementary particles

    CERN Document Server

    Griffiths, David J

    2008-01-01

    This is the first quantitative treatment of elementary particle theory that is accessible to undergraduates. Using a lively, informal writing style, the author strikes a balance between quantitative rigor and intuitive understanding. The first chapter provides a detailed historical introduction to the subject. Subsequent chapters offer a consistent and modern presentation, covering the quark model, Feynman diagrams, quantum electrodynamics, and gauge theories. A clear introduction to the Feynman rules, using a simple model, helps readers learn the calculational techniques without the complicat

  8. Introduction to Geostatistics

    Science.gov (United States)

    Kitanidis, P. K.

    1997-05-01

    Introduction to Geostatistics presents practical techniques for engineers and earth scientists who routinely encounter interpolation and estimation problems when analyzing data from field observations. Requiring no background in statistics, and with a unique approach that synthesizes classic and geostatistical methods, this book offers linear estimation methods for practitioners and advanced students. Well illustrated with exercises and worked examples, Introduction to Geostatistics is designed for graduate-level courses in earth sciences and environmental engineering.

  9. Introduction to remote sensing

    CERN Document Server

    Cracknell, Arthur P

    2007-01-01

    Addressing the need for updated information in remote sensing, Introduction to Remote Sensing, Second Edition provides a full and authoritative introduction for scientists who need to know the scope, potential, and limitations in the field. The authors discuss the physical principles of common remote sensing systems and examine the processing, interpretation, and applications of data. This new edition features updated and expanded material, including greater coverage of applications from across earth, environmental, atmospheric, and oceanographic sciences. Illustrated with remotely sensed colo

  10. Plasma physics an introduction

    CERN Document Server

    Fitzpatrick, Richard

    2014-01-01

    Plasma Physics: An Introduction is based on a series of university course lectures by a leading name in the field, and thoroughly covers the physics of the fourth state of matter. This book looks at non-relativistic, fully ionized, nondegenerate, quasi-neutral, and weakly coupled plasma. Intended for the student market, the text provides a concise and cohesive introduction to plasma physics theory, and offers a solid foundation for students wishing to take higher level courses in plasma physics.

  11. Screening in larval zebrafish reveals tissue-specific distribution of fifteen fluorescent compounds

    Directory of Open Access Journals (Sweden)

    Yuxiao Yao

    2017-09-01

    Full Text Available The zebrafish is a prominent vertebrate model for low-cost in vivo whole organism screening. In our recent screening of the distribution patterns of fluorescent compounds in live zebrafish larvae, fifteen compounds with tissue-specific distributions were identified. Several compounds were observed to accumulate in tissues where they were reported to induce side-effects, and compounds with similar structures tended to be enriched in the same tissues, with minor differences. In particular, we found three novel red fluorescent bone-staining dyes: purpurin, lucidin and 3-hydroxy-morindone; purpurin can effectively label bones in both larval and adult zebrafish, as well as in postnatal mice, without significantly affecting bone mass and density. Moreover, two structurally similar chemotherapeutic compounds, doxorubicin and epirubicin, were observed to have distinct distribution preferences in zebrafish. Epirubicin maintained a relatively higher concentration in the liver, and performed better in inhibiting hepatic hyperplasia caused by the over-expression of krasG12V. In total, our study suggests that the transparent zebrafish larvae serve as valuable tools for identifying tissue-specific distributions of fluorescent compounds.

  12. The Physics and Chemistry of Color: The Fifteen Causes of Color, 2nd Edition

    Science.gov (United States)

    Nassau, Kurt

    2001-07-01

    An updated and revised second edition of the acclaimed classic Have you ever wondered why the sky is blue, or a ruby red? This classic volume studies the physical and chemical origins of color by exploring fifteen separate causes of color and their varied and often subtle occurrences in biology, geology, mineralogy, the atmosphere, technology, and the visual arts. It covers all of the fundamental concepts at work and requires no specialized knowledge. Author Kurt Nassau includes hundreds of illustrations, tables, and photographs-as well as end-of-chapter problems-that aid in visualizing the concepts discussed. An updated bibliography permits readers to pursue their own particular interests and an expanded series of appendices cover advanced topics. The Physics and Chemistry of Color, Second Edition is a one-of-a-kind treatment of color that provides both detailed physical and chemical properties of color and a more general overview of the subject. It will prove highly useful to specialists and non-specialists alike-and fascinate those with varied interests from optics to art history.

  13. An introduction to relativistic hydrodynamics

    Energy Technology Data Exchange (ETDEWEB)

    Font, Jose A [Departamento de AstronomIa y AstrofIsica, Universidad de Valencia, Dr. Moliner 50, 46100 Burjassot (Valencia) (Spain)

    2007-11-15

    We review formulations of the equations of (inviscid) general relativistic hydrodynamics and (ideal) magnetohydrodynamics, along with methods for their numerical solution. Both systems can be cast as first-order, hyperbolic systems of conservation laws, following the explicit choice of an Eulerian observer and suitable fluid and magnetic field variables. During the last fifteen years, the so-called (upwind) high-resolution shock-capturing schemes based on Riemann solvers have been successfully extended from classical to relativistic fluid dynamics, both special and general. Nowadays, general relativistic hydrodynamical simulations in relativistic astrophysics are routinely performed, particularly within the test-fluid approximation but also for dynamical spacetimes. While such advances also hold true in the case of the MHD equations, the astrophysical applications investigated so far are still limited, yet the field is bound to witness major developments in the near future. The article also presents a brief overview of numerical techniques, providing state-of-the-art examples of their applicability to general relativistic fluids and magneto-fluids in characteristic scenarios of relativistic astrophysics.

  14. Complexity a very short introduction

    CERN Document Server

    Holland, John H

    2014-01-01

    The importance of complexity is well-captured by Hawking's comment: "Complexity is the science of the 21st century". From the movement of flocks of birds to the Internet, environmental sustainability, and market regulation, the study and understanding of complex non-linear systems has become highly influential over the last 30 years. In this Very Short Introduction, one of the leading figures in the field, John Holland, introduces the key elements and conceptual framework of complexity. From complex physical systems such as fluid flow and the difficulties of predicting weather, to complex adaptive systems such as the highly diverse and interdependent ecosystems of rainforests, he combines simple, well-known examples - Adam Smith's pin factory, Darwin's comet orchid, and Simon's 'watchmaker' - with an account of the approaches, involving agents and urn models, taken by complexity theory. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost eve...

  15. Introduction to AC machine design

    CERN Document Server

    Lipo, Thomas A

    2018-01-01

    AC electrical machine design is a key skill set for developing competitive electric motors and generators for applications in industry, aerospace, and defense. This book presents a thorough treatment of AC machine design, starting from basic electromagnetic principles and continuing through the various design aspects of an induction machine. Introduction to AC Machine Design includes one chapter each on the design of permanent magnet machines, synchronous machines, and thermal design. It also offers a basic treatment of the use of finite elements to compute the magnetic field within a machine without interfering with the initial comprehension of the core subject matter. Based on the author's notes, as well as after years of classroom instruction, Introduction to AC Machine Design: * Brings to light more advanced principles of machine design--not just the basic principles of AC and DC machine behavior * Introduces electrical machine design to neophytes while also being a resource for experienced designers * ...

  16. Cumulative Index to the First Fifteen Semiannual Reports of the Commission to the Congress. January 1947 - 1953

    Energy Technology Data Exchange (ETDEWEB)

    Dean, Gordon

    1954-01-31

    The first fifteen semiannual reports of the United States Atomic Energy Commission to Congress cover the major unclassified activities of the Commission from January 1947 through December 1953. This cumulative name and subject index provides a guide to the information published in these reports.

  17. Environmentalism in the Periphery: Institutional Embeddedness and Deforestation among Fifteen Palm Oil Producers, 1990 – 2012

    Directory of Open Access Journals (Sweden)

    Kent Henderson

    2017-08-01

    Full Text Available Environmental sociologists highlight the exploitative nature of the global capitalist economy where resource extraction from nations in the periphery tends to disproportionately benefit those of the core. From the Brazilian Amazon to mineral-rich Sub-Saharan Africa, the practice of “unequal ecological exchange” persists. Simultaneously, a “global environmental regime” has coalesced as a prominent feature of the contemporary world system. In the post-World War II era, legitimate nation-states must take steps to protect the natural environment and prevent its degradation even at their own economic expense. Stronger national ties to global institutions, particularly international nongovernmental organizations (INGOs consistently yield more positive environmental outcomes. However, previous work suggests that normative expectations for improved environmental practice will be weak or nonexistent in the periphery. We use the case of palm oil production and its relationship to deforestation to provide a more nuanced analysis of the relationship between material and institutional forces in the periphery. Using unbalanced panels of fifteen palm oil producing countries from 1990 to 2012, we find that stronger national ties to world society via citizen memberships in INGOs result in greater primary forest area among palm oil producers. However, this effect is strongest where production is lowest and weakens as production increases. Even in the cases of Indonesia and Malaysia, where palm oil production is substantially higher than any other producer, ties to global institutions are significantly related to reduced forest loss. These results indicate the variable importance of national embeddedness into global institutions within the periphery of the world system.

  18. Fifteen fatal fallacies of financial fundamentalism Quince falacias funestas del fundamentalismo financiero

    Directory of Open Access Journals (Sweden)

    Vickrey William

    1999-06-01

    Full Text Available In this article, Professor Vickrey shows that current economic policy is based on incomplete analyses, counterfactual assumptions, and false analogies. The article examines in detail fifteen fallacies which, taken together, lead to policies which at best generate economic lethargy with unemployment rates close to 5 or 6 percent. For Professor Vickrey, this situation is harmful in that it reduces potential production between 10 and 15 percent even if the loss is distributed in an equitable way among the population; but when it turns into unemployment of 10, 20, and up to 40 percent for the less favored groups, the additional harm in terms of poverty, family breakup, school absence and dropout, illegitimacy,
    drug use, and crime becomes very serious. Thus these policies are like a 'premeditated homicidal fire' and, even worse, when they are carried to their ultimate consequences, in search of 'budgetary equilibrium', they can lead to a deep depression.En este articulo, el profesor Vickrey muestra que la politica economica actual se basa en analisis incompletos, supuestos contrafactuales y analogias falsas. El articulo examina en detalle quince falacias que, en conjunto, llevan a politicas que, en el mejor de los casos, generan un letargo economico con tasas de desempleo cercanas al 5 o 6 por ciento. Para el profesor Vickrey, esta situacion es perjudicial por cuanto reduce la produccion potencial entre un 10 y un 15 por ciento aun asi la perdida de se reparte de forma equitativa entre toda la poblacion; pero cuando se traduce un desempleo de 10, 20 o hasta 40 por ciento para los grupos desfavorecidos, los perjuicios adicionales en terminos de pobreza, ruptura familiar, ausencia y desercion escolar, ilegitimidad, uso de drogas y crimenes llegan a ser muy graves. De modo que estas politicas se asemejan a un "incendio homicida premeditado" y, aun peor, cuando se llevan hasta sus ultimas concecuencias, en busca de un 'presupuesto equilibrado

  19. Biophysics an introduction

    CERN Document Server

    Cotteril, Rodney

    2002-01-01

    Biophysics: An Introduction, is a concise balanced introduction to this subject. Written in an accessible and readable style, the book takes a fresh, modern approach with the author successfully combining key concepts and theory with relevant applications and examples drawn from the field as a whole. Beginning with a brief introduction to the origins of biophysics, the book takes the reader through successive levels of complexity, from atoms to molecules, structures, systems and ultimately to the behaviour of organisms. The book also includes extensive coverage of biopolymers, biomembranes, biological energy, and nervous systems. The text not only explores basic ideas, but also discusses recent developments, such as protein folding, DNA/RNA conformations, molecular motors, optical tweezers and the biological origins of consciousness and intelligence.

  20. Introduction to magnetochemistry

    CERN Document Server

    Earnshaw, Alan

    2013-01-01

    Introduction to Magnetochemistry provides an introduction to the more important aspects of magnetochemistry. The measurement of magnetic moment has been one of the most consistently useful to coordination chemists. For teaching purposes it provides a simple method of illustrating the ideas of electronic structure, and in research it can provide fundamental information about the bonding and stereochemistry of complexes. The book contains six chapters covering topics such as free atoms and ions, transition metal complexes, crystal field theory, second and third row transition metal complexes, a

  1. An Introduction to Malware

    DEFF Research Database (Denmark)

    Sharp, Robin

    2007-01-01

    These notes intended for use in DTU course 02233 on Network Security give a short introduction to the topic of malware. The most important types of malware are described, together with their basic principles of operation and dissemination, and defences against malware are discussed.......These notes intended for use in DTU course 02233 on Network Security give a short introduction to the topic of malware. The most important types of malware are described, together with their basic principles of operation and dissemination, and defences against malware are discussed....

  2. An Introduction to Malware

    DEFF Research Database (Denmark)

    Sharp, Robin

    2017-01-01

    These notes, intended for use in DTU course 02233 on Network Security, give a short introduction to the topic of malware. The most important types of malware are described, together with their basic principles of operation and dissemination, and defenses against malware are discussed.......These notes, intended for use in DTU course 02233 on Network Security, give a short introduction to the topic of malware. The most important types of malware are described, together with their basic principles of operation and dissemination, and defenses against malware are discussed....

  3. Introduction to quantum groups

    CERN Document Server

    Chaichian, Masud

    1996-01-01

    In the past decade there has been an extemely rapid growth in the interest and development of quantum group theory.This book provides students and researchers with a practical introduction to the principal ideas of quantum groups theory and its applications to quantum mechanical and modern field theory problems. It begins with a review of, and introduction to, the mathematical aspects of quantum deformation of classical groups, Lie algebras and related objects (algebras of functions on spaces, differential and integral calculi). In the subsequent chapters the richness of mathematical structure

  4. Applied energy an introduction

    CERN Document Server

    Abdullah, Mohammad Omar

    2012-01-01

    Introduction to Applied EnergyGeneral IntroductionEnergy and Power BasicsEnergy EquationEnergy Generation SystemsEnergy Storage and MethodsEnergy Efficiencies and LossesEnergy industry and Energy Applications in Small -Medium Enterprises (SME) industriesEnergy IndustryEnergy-Intensive industryEnergy Applications in SME Energy industriesEnergy Sources and SupplyEnergy SourcesEnergy Supply and Energy DemandEnergy Flow Visualization and Sankey DiagramEnergy Management and AnalysisEnergy AuditsEnergy Use and Fuel Consumption StudyEnergy Life-Cycle AnalysisEnergy and EnvironmentEnergy Pollutants, S

  5. Introduction to nonimaging optics

    CERN Document Server

    Chaves, Julio

    2015-01-01

    Introduction to Nonimaging Optics covers the theoretical foundations and design methods of nonimaging optics, as well as key concepts from related fields. This fully updated, revised, and expanded Second Edition: Features a new and intuitive introduction with a basic description of the advantages of nonimaging opticsAdds new chapters on wavefronts for a prescribed output (irradiance or intensity), infinitesimal étendue optics (generalization of the aplanatic optics), and Köhler optics and color mixingIncorporates new material on the simultaneous multiple surface (SMS) design method in 3-D, int

  6. Introduction to fuzzy systems

    CERN Document Server

    Chen, Guanrong

    2005-01-01

    Introduction to Fuzzy Systems provides students with a self-contained introduction that requires no preliminary knowledge of fuzzy mathematics and fuzzy control systems theory. Simplified and readily accessible, it encourages both classroom and self-directed learners to build a solid foundation in fuzzy systems. After introducing the subject, the authors move directly into presenting real-world applications of fuzzy logic, revealing its practical flavor. This practicality is then followed by basic fuzzy systems theory. The book also offers a tutorial on fuzzy control theory, based mainly on th

  7. Introduction to information processing

    CERN Document Server

    Dietel, Harvey M

    2014-01-01

    An Introduction to Information Processing provides an informal introduction to the computer field. This book introduces computer hardware, which is the actual computing equipment.Organized into three parts encompassing 12 chapters, this book begins with an overview of the evolution of personal computing and includes detailed case studies on two of the most essential personal computers for the 1980s, namely, the IBM Personal Computer and Apple's Macintosh. This text then traces the evolution of modern computing systems from the earliest mechanical calculating devices to microchips. Other chapte

  8. Game theory an introduction

    CERN Document Server

    Barron, E N

    2013-01-01

    An exciting new edition of the popular introduction to game theory and its applications The thoroughly expanded Second Edition presents a unique, hands-on approach to game theory. While most books on the subject are too abstract or too basic for mathematicians, Game Theory: An Introduction, Second Edition offers a blend of theory and applications, allowing readers to use theory and software to create and analyze real-world decision-making models. With a rigorous, yet accessible, treatment of mathematics, the book focuses on results that can be used to

  9. Acoustics an introduction

    CERN Document Server

    Kuttruff, Heinrich

    2006-01-01

    This definitive textbook provides students with a comprehensive introduction to acoustics. Beginning with the basic physical ideas, Acoustics balances the fundamentals with engineering aspects, applications and electroacoustics, also covering music, speech and the properties of human hearing. The concepts of acoustics are exposed and applied in:room acousticssound insulation in buildingsnoise controlunderwater sound and ultrasoundScientifically thorough, but with mathematics kept to a minimum, Acoustics is the perfect introduction to acoustics for students at any level of mechanical, electrical or civil engineering courses and an accessible resource for architects, musicians or sound engineers requiring a technical understanding of acoustics and their applications.

  10. Introduction to nuclear reactions

    International Nuclear Information System (INIS)

    Satchler, G.R.

    1980-01-01

    This introduction to nuclear reaction phenomena is aimed primarily but not exclusively at readers at the undergraduate student level. An overview of the subject is presented in the first two chapters entitled - Some background information and Introduction to nuclear reactions. The third chapter reviews scattering theory with emphasis on the underlying physical ideas and also provides schematic entrees to the more advanced topics. The physical models which have been developed to account for the various aspects of nuclear phenomena are described in more detail in chapter 4. References and exercises are appended to each chapter. (U.K.)

  11. Introduction to the Project

    DEFF Research Database (Denmark)

    Kuhn, Johan M.; Malchow-Møller, Nikolaj; Sørensen, Anders

    In this note a short introduction to the project “Employment Effects of Entrepreneurs” is presented. First, we describe the purpose of the project; second, we present the background; third, we briefly describe the three papers that constitute the output of the project, and fourth, we discuss two ...... important qualifications for the understanding of the contributions and results established in the project.......In this note a short introduction to the project “Employment Effects of Entrepreneurs” is presented. First, we describe the purpose of the project; second, we present the background; third, we briefly describe the three papers that constitute the output of the project, and fourth, we discuss two...

  12. Introduction to UAV systems

    CERN Document Server

    Fahlstrom, Paul

    2012-01-01

    Unmanned aerial vehicles (UAVs) have been widely adopted in the military world over the last decade and the success of these military applications is increasingly driving efforts to establish unmanned aircraft in non-military roles. Introduction to UAV Systems, 4th edition provides a comprehensive introduction to all of the elements of a complete Unmanned Aircraft System (UAS). It addresses the air vehicle, mission planning and control, several types of mission payloads, data links and how they interact with mission performance, and launch and recovery concepts. This

  13. Fall Protection Introduction, #33462

    Energy Technology Data Exchange (ETDEWEB)

    Chochoms, Michael [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-06-23

    The proper use of fall prevention and fall protection controls can reduce the risk of deaths and injuries caused by falls. This course, Fall Protection Introduction (#33462), is designed as an introduction to various types of recognized fall prevention and fall protection systems at Los Alamos National Laboratory (LANL), including guardrail systems, safety net systems, fall restraint systems, and fall arrest systems. Special emphasis is given to the components, inspection, care, and storage of personal fall arrest systems (PFASs). This course also presents controls for falling object hazards and emergency planning considerations for persons who have fallen.

  14. Introduction to plasma dynamics

    CERN Document Server

    Morozov, A I

    2013-01-01

    As the twenty-first century progresses, plasma technology will play an increasing role in our lives, providing new sources of energy, ion-plasma processing of materials, wave electromagnetic radiation sources, space plasma thrusters, and more. Studies of the plasma state of matter not only accelerate technological developments but also improve the understanding of natural phenomena. Beginning with an introduction to the characteristics and types of plasmas, Introduction to Plasma Dynamics covers the basic models of classical diffuse plasmas used to describe such phenomena as linear and shock w

  15. An introduction to English grammar

    CERN Document Server

    Nelson, Gerald C

    2013-01-01

    English Language and its usage has become extremely emotive issues in recent years. Recurring discussions in the media have highlighted a growing demand for a return to the study of language after decades of neglect. This book is an introductory descriptive survey, intended for students, teachers and general readers which offers coverage of grammatical topics with sections on spelling, punctuation and exercises.Clear and concise, this much needed third edition of Gerald Nelson and the late Sidney Greenbaum's introduction will be of immense value to students who have little or no experience of

  16. Relativity a very short introduction

    CERN Document Server

    Stannard, F Russell

    2008-01-01

    Relativity: A Very Short Introduction makes the theory of relativity understandable and accessible. 100 years ago, Einstein's theory of relativity shattered the world of physics. Our comforting Newtonian ideas of space and time were replaced by bizarre and counterintuitive conclusions: if you move at high speed, time slows down, space squashes up and you get heavier; travel fast enough and you could weigh as much as a jumbo jet, be squashed thinner than a CD without feeling a thing - and live forever. And that was just the special theory. With the general theory came even stranger ideas of curved space-time, which changed our understanding of gravity and the cosmos.

  17. Introduction to mathematics of satisfiability

    CERN Document Server

    Marek, Victor W

    2009-01-01

    Although this area has a history of over 80 years, it was not until the creation of efficient SAT solvers in the mid-1990s that it became practically important, finding applications in electronic design automation, hardware and software verification, combinatorial optimization, and more. Exploring the theoretical and practical aspects of satisfiability, Introduction to Mathematics of Satisfiability focuses on the satisfiability of theories consisting of propositional logic formulas. It describes how SAT solvers and techniques are applied to problems in mathematics and computer science as well

  18. Planets a very short introduction

    CERN Document Server

    Rothery, David A

    2010-01-01

    Planets: A Very Short Introduction demonstrates the excitement, uncertainties, and challenges faced by planetary scientists, and provides an overview of our Solar System and its origins, nature, and evolution. Terrestrial planets, giant planets, dwarf planets and various other objects such as satellites (moons), asteroids, trans-Neptunian objects, and exoplanets are discussed. Our knowledge about planets has advanced over the centuries, and has expanded at a rapidly growing rate in recent years. Controversial issues are outlined, such as What qualifies as a planet? What conditions are required for a planetary body to be potentially inhabited by life? Why does Pluto no longer have planet status? And Is there life on other planets?

  19. An Introduction to Cognitive Musicology

    DEFF Research Database (Denmark)

    Haumann, Niels Trusbak

    2015-01-01

    This historical-scientific introduction to Cognitive Musicology introduces the 150 years of research and discoveries in the psychology of music that partly presuppose the more recent discipline of Cognitive Musicology. Atomistic, Gestalt, functionalist, testing, behaviorist, cognitive......, and neuroscience approaches to the psychological mechanisms underlying music are presented. Thus, it is argued that Cognitive Musicology is partly based on firm historical traditions in the psychology of music. Also discussed is the way in which the combination of interdisciplinary methods from the humanities...... and the natural sciences, which is integrated in Cognitive Musicology, may minimize the limitations of the separate humanities-based or natural science methods....

  20. Introduction to quantum groups

    International Nuclear Information System (INIS)

    Monteiro, Marco A.R.

    1994-01-01

    An elementary introduction to quantum groups is presented. The example of Universal Enveloping Algebra of deformed SU(2) is analysed in detail. It is also discussed systems made up of bosonic q-oscillators at finite temperature within the formalism of Thermo-Field Dynamics. (author). 39 refs

  1. Introduction to nucleosynthesis

    International Nuclear Information System (INIS)

    Guasp, J.

    1975-01-01

    After a short introduction on stellar evolution, the physical foundations of nucleosynthesis are exposed: H, He, C and O fusion, Si burning and the equilibrium process. The effect of neutrinos in the last stages of stellar evolution and Supernova explosions are treated too. Afterwards the neutron capture process, fast and slow, are considerated concluding with cosmic nucleogenesis and nucleosynthesis in overmasive objects. (author)

  2. Russian: An Active Introduction.

    Science.gov (United States)

    De La Cruz, Nina

    The Active Introduction is one of the modules in an array of materials used in Russian training for beginners at the Foreign Service Institute. It is essentially a catalog of sentences relating to typical daily activities which can be combined to form different communication sequences in dialog form. Students learn to speak Russian through…

  3. Introduction to the Project

    DEFF Research Database (Denmark)

    Kuhn, Johan M.; Malchow-Møller, Nikolaj; Sørensen, Anders

    In this note a short introduction to the project “Employment Effects of Entrepreneurs” is presented. First, we describe the purpose of the project; second, we present the background; third, we briefly describe the three papers that constitute the output of the project, and fourth, we discuss two...... important qualifications for the understanding of the contributions and results established in the project....

  4. Introduction to LCA Methodology

    DEFF Research Database (Denmark)

    Hauschild, Michael Z.

    2018-01-01

    In order to offer the reader an overview of the LCA methodology in the preparation of the more detailed description of its different phases, a brief introduction is given to the methodological framework according to the ISO 14040 standard and the main elements of each of its phases. Emphasis...

  5. Introduction to Chiral Symmetry

    Energy Technology Data Exchange (ETDEWEB)

    Koch, Volker [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2017-05-09

    These lectures are an attempt to a pedagogical introduction into the elementary concepts of chiral symmetry in nuclear physics. We will also discuss some effective chiral models such as the linear and nonlinear sigma model as well as the essential ideas of chiral perturbation theory. We will present some applications to the physics of ultrarelativistic heavy ion collisionsd.

  6. Introduction: Adapting Idols

    NARCIS (Netherlands)

    Joost Bruin; dr. Koos Zwaan

    2012-01-01

    Introduction book Adapting Idols Since the first series of Pop Idol aired in the UK just over a decade ago, Idols television shows have been broadcast in more than forty countries all over the world. In all those countries the global Idols format has been adapted to local cultures and production

  7. Introduction to topology

    CERN Document Server

    Mendelson, Bert

    1990-01-01

    Highly regarded for its exceptional clarity, imaginative and instructive exercises, and fine writing style, this concise book offers an ideal introduction to the fundamentals of topology. It provides a simple, thorough survey of elementary topics, starting with set theory and advancing to metric and topological spaces, connectedness, and compactness. 1975 edition.

  8. Introduction to statistics

    CERN Multimedia

    CERN. Geneva

    2005-01-01

    The three lectures will present an introduction to statistical methods as used in High Energy Physics. As the time will be very limited, the course will seek mainly to define the important issues and to introduce the most wide used tools. Topics will include the interpretation and use of probability, estimation of parameters and testing of hypotheses.

  9. Introduction to Statistics course

    CERN Multimedia

    CERN. Geneva HR-RFA

    2006-01-01

    The four lectures will present an introduction to statistical methods as used in High Energy Physics. As the time will be very limited, the course will seek mainly to define the important issues and to introduce the most wide used tools. Topics will include the interpretation and use of probability, estimation of parameters and testing of hypotheses.

  10. Introduction: The Transparency Issue

    NARCIS (Netherlands)

    Teurlings, J.; Stauff, M.

    2014-01-01

    Besides giving an overview on the individual contributions, this introduction to the special issue on transparency delineates a conceptual context for a critical analysis of the contemporary discourse on transparency and the media mechanisms related to it. It focuses on three ambivalences inherent

  11. Introduction to International Trade.

    Science.gov (United States)

    Crummett, Dan M.; Crummett, Jerrie

    This set of student and teacher guides is intended for use in a course to prepare students for entry-level employment in such occupational areas in international trade as business/finance, communications, logistics, and marketing. The following topics are covered in the course's five instructional units: introduction to careers in international…

  12. Introduction to association schemes

    NARCIS (Netherlands)

    Seidel, J.J.

    1991-01-01

    The present paper gives an introduction to the theory of association schemes, following Bose-Mesner (1959), Biggs (1974), Delsarte (1973), Bannai-Ito (1984) and Brouwer-Cohen-Neumaier (1989). Apart from definitions and many examples, also several proofs and some problems are included. The paragraphs

  13. An introduction to radiobiology

    International Nuclear Information System (INIS)

    Nias, A.H.W.; Dimbleby, R.

    1990-01-01

    This text provides an introduction to quantitative radiobiology with emphasis on practical aspects of the subject. Among the topics considered are reparable damage, densely ionizing radiation, normal and malignant cells, and whole body regulation. These and other aspects of radiation biology are described in detail

  14. Introduction to Shakespeare: English.

    Science.gov (United States)

    Hargraves, Richard

    The "Introduction to Shakespeare" course in the Quinmester Program involves the careful study of the tragedy "Romeo and Juliet" and the comedy "The Taming of the Shrew," emphasizing language, development of character and theme. The course also includes the study of biographical data relevant to the evolution of…

  15. Introduction to chiral symmetry

    International Nuclear Information System (INIS)

    Koch, V.

    1996-01-01

    These lectures are an attempt to a pedagogical introduction into the elementary concepts of chiral symmetry in nuclear physics. Effective chiral models such as the linear and nonlinear sigma model will be discussed as well as the essential ideas of chiral perturbation theory. Some applications to the physics of ultrarelativistic heavy ion collisions will be presented

  16. Introduction to HACCP.

    Science.gov (United States)

    Introduction to HACCP Deana R. Jones, Ph.D. Egg Safety and Quality Research Unit USDA-Agricultural Research Service Russell Research Center Athens, GA Deana.Jones@ars.usda.gov HACCP is an acronym for Hazard Analysis and Critical Control Point and was initially developed by the Pillsbury Company a...

  17. An Introduction to Malware

    OpenAIRE

    Sharp, Robin

    2017-01-01

    These notes, intended for use in DTU course 02233 on Network Security, give a short introduction to the topic of malware. The most important types of malware are described, together with their basic principles of operation and dissemination, and defenses against malware are discussed.

  18. Introduction to statistics

    CERN Multimedia

    CERN. Geneva

    2004-01-01

    The three lectures will present an introduction to statistical methods as used in High Energy Physics. As the time will be very limited, the course will seek mainly to define the important issues and to introduce the most wide used tools. Topics will include the interpretation and use of probability, estimation of parameters and testing of hypotheses.

  19. Introduction to ROC analysis

    International Nuclear Information System (INIS)

    Kelsey, C.A.; Mettler, F.A.

    1988-01-01

    An elementary introduction to ROC analysis illustrates how ROC curves depend on observer threshold levels and discusses the relation between ROC curve parameters and other measures of observer performance including accuracy sensitivity specificity true positive fraction, true negative fraction, false positive fraction and false negative fraction

  20. Introduction and fundamentals

    International Nuclear Information System (INIS)

    Thomas, R.H.

    1980-01-01

    This introduction discusses advances in the fundamental sciences which underlie the applied science of health physics and radiation protection. Risk assessments in nuclear medicine are made by defining the conditions of exposure, identification of adverse effects, relating exposure with effect, and estimation of the overall risk for ionizing radiations

  1. Labour and Passion. : Introduction

    NARCIS (Netherlands)

    Dr. Joke Hermes

    2014-01-01

    Abstract In this introduction to the themed section on ‘Labour and passion’, it is argued that work has bled into all areas of life. Political economists and media production researchers have shown how both paid and unpaid labour are singularly important and build upon one another. The set of

  2. Diophantine geometry an introduction

    CERN Document Server

    Hindry, Marc

    2000-01-01

    This is an introduction to diophantine geometry at the advanced graduate level. The book contains a proof of the Mordell conjecture which will make it quite attractive to graduate students and professional mathematicians. In each part of the book, the reader will find numerous exercises.

  3. Introduction to superstrings

    International Nuclear Information System (INIS)

    Kaku, M.

    1988-01-01

    This tutorial introduces the development of, and current trends in, superstring theory, a significant and still controversial attempt to unify general relatively and quantum field theory. Stressing current areas of research activity, Introduction to Superstrings addresses topics including string field theory, multi-loops and Teichmuller spaces, conformal field theory, and four-dimensional superstrings

  4. Introduction to number theory

    CERN Document Server

    Vazzana, Anthony; Garth, David

    2007-01-01

    One of the oldest branches of mathematics, number theory is a vast field devoted to studying the properties of whole numbers. Offering a flexible format for a one- or two-semester course, Introduction to Number Theory uses worked examples, numerous exercises, and two popular software packages to describe a diverse array of number theory topics.

  5. Biorefineries: A Short Introduction.

    Science.gov (United States)

    Wagemann, Kurt; Tippkötter, Nils

    2018-04-13

    The terms bioeconomy and biorefineries are used for a variety of processes and developments. This short introduction is intended to provide a delimitation and clarification of the terminology as well as a classification of current biorefinery concepts. The basic process diagrams of the most important biorefinery types are shown.

  6. Introduction to Film.

    Science.gov (United States)

    Burns, Gary

    There are numerous ways to structure the introduction to film course so as to meet the needs of the different types of students who typically enroll. Assuming there is no production component in the course, the teacher is left with two major approaches to choose from--historical and aesthetic. The units in the course will typically be built around…

  7. Introduction to Film Making.

    Science.gov (United States)

    Davis, Robert E.

    This booklet is intended for teachers who are now teaching units in film production as part of a program in communication or who wish to begin work with filmmaking in such a program. The first section is intended to serve as a brief introduction to film theory, while a major portion of the rest of the booklet is devoted to film projects which may…

  8. Introduction to particle physics

    International Nuclear Information System (INIS)

    Zitoun, R.

    2000-01-01

    This book proposes an introduction to particle physics that requires only a high-school level mathematical knowledge. Elementary particles (leptons, quarks, bosons) are presented according to a modern view taking into account of their symmetries and interactions. The author shows how physicists have elaborated the standard model and what are its implications in cosmology. (J.S.)

  9. Introduction to risk assessment

    International Nuclear Information System (INIS)

    Raina, V.M.

    2002-01-01

    This paper gives an introduction to risk assessment. It discusses the basic concepts of risk assessment, nuclear risk assessment process and products, the role of risk assessment products in nuclear safety assurance, the relationship between risk assessment and other safety analysis and risk assessment and safe operating envelope

  10. Successful introduction of innovations

    International Nuclear Information System (INIS)

    Schoots, K.; Jeeninga, H.

    2008-01-01

    The introduction of new technology is sometimes troubled by discontinuity in incentive schemes. By making prior assessments of the necessary means, the real time span for the incentive scheme and by maintaining this scheme until the technology is mature enough to enter the market, the success of innovation trajectories can be increased significantly. [mk] [nl

  11. Successful introduction of innovation

    International Nuclear Information System (INIS)

    Schoots, K.; Jeeninga, H.

    2008-01-01

    The introduction of new technology sometimes proceeds sluggishly due to discontinuity in incentive schemes. Estimating in advance which means are required, what a realistic time span is for the incentive scheme and continuing this scheme until the technology is marketable can significantly increase the success of innovation trajectories. [mk] [nl

  12. Chemical Safety – Introduction

    CERN Multimedia

    DG Unit

    2009-01-01

    A course of "Chemical Safety – Introduction" will be held in English on 29 May 2009, 9:30-12:00. There are some places left. If you are interested in participating, please register on the Training Catalogue. You will then receive an invitation by email.

  13. Targeted scan of fifteen regions for nonsyndromic cleft lip and palate in Filipino families.

    Science.gov (United States)

    Schultz, R E; Cooper, M E; Daack-Hirsch, S; Shi, M; Nepomucena, B; Graf, K A; O'Brien, E K; O'Brien, S E; Marazita, M L; Murray, J C

    2004-02-15

    Cleft lip with or without cleft palate (CL/P) is a congenital anomaly with variable birth prevalence based on geographic origins, with the highest rates commonly found in Asian populations. About 70% of cases are nonsyndromic (NS), in which the affected individual has no other abnormalities. NS CL/P is a complex disorder with genetic and environmental effects and no specific genetic loci yet confirmed. Fifteen candidate regions were examined for linkage to NS CL/P. Regions were chosen based on previous suggestive linkage and/or association in human families, or suggestive animal model data. Polymorphic markers in these regions were genotyped for analysis on 36 Filipino families comprised of 126 affected and 218 unaffected individuals. An additional 70 families with 149 affecteds were used for replication of suggestive results. Parametric (LOD score) and nonparametric (SIMIBD) linkage analyses were performed as well as transmission disequilibrium test (TDT) analysis. Five markers yielded suggestive results from the 36 families. The parametric LOD scores for the MSX1-CA and D4S1629 were >1.0 and the SIMIBD P values for D6S1029 and RFC1 are suggestive (value of 0.01 for TGFA was significant. Since the Msx1 mouse knockout has cleft palate and MSX1 mutations have been found in rare cases of syndromic CL/P, this locus is especially plausible for linkage. Previous studies have also found linkage of NS CL/P to 4q31 and 6p23. These regions contain several candidate genes, including AP2 at 6p23 and FGF2, BMPR1B, and MADH1 at 4q31. TGFA has both linkage and linkage disequilibrium data supporting it as a candidate gene for NS CL/P. While no region was definitively confirmed for linkage to NS CL/P, the data do support further investigation using larger sample sizes and candidate gene studies at 2p13.2, 4p16.2, 4q31, 6p23, and 16q22-24. Copyright 2003 Wiley-Liss, Inc.

  14. Fifteen symposia on microdosimetry: implications for modern particle-beam cancer radiotherapy

    CERN Document Server

    Wambersie, A; Gueulette, J; Pihet, P

    2015-01-01

    The objective of microdosimetry was, and still is, to identify physical descriptions of the initial physical processes of ionising radiation interacting with biological matter which correlate with observed radiobiological effects with a view to improve the understanding of radiobiological mechanisms and effects. The introduction of therapy with particles starting with fast neutrons followed by negative pions, protons and light ions necessitated the application of biological weighting factors for absorbed dose in order to account for differences of the relative biological effectiveness (RBE). Dedicated radiobiological experiments in therapy beams with mammalian cells and with laboratory animals provided sets of RBE values which are used to evaluate empirical ‘clinical RBE values’. The combination of such experiments with microdosimetric measurements in identical conditions offered the possibility to establish semi-empirical relationships between microdosimetric parameters and results of RBE studies.

  15. Eleutherodactylus frog introductions to Hawaii

    Science.gov (United States)

    Kraus, Fred; Campbell, Earl W.; Allison, Allen; Pratt, Thane K.

    1999-01-01

    As an oceanic archipelago isolated from continental source areas, Hawaii lacks native terrestrial reptiles and amphibians, Polynesians apparently introduced seven gecko and skink species after discovering the islands approximately 1500 years ago, and another 15 reptiles and five frogs have been introduced in the last century and a half (McKeown 1996). The Polynesian introductions are probably inadvertent because the species involved are known stowaway dispersers (Gibbons 1985; Dye and Steadman 1990), In contrast, most of the herpetological introductions since European contact with Hawaii have been intentional. Several frog species were released for biocontrol of insects (e.g., Dendrobates auratus, Bufo marinus, Rana rugosa, Bryan 1932; Oliver and Shaw 1953), and most of the remaining species are released or escaped pets (e.g., Phelsuma spp., Chamaeleo jacksonii, Iguana iguana, McKeown 1996), Government-approved releases have not occurred for many years, but the rate of establishment of new species has increased in the past few decades because of the importation and subsequent release of pets.

  16. Introduction to modern magnetohydrodynamics

    CERN Document Server

    Galtier, Sébastien

    2016-01-01

    Ninety-nine percent of ordinary matter in the Universe is in the form of ionized fluids, or plasmas. The study of the magnetic properties of such electrically conducting fluids, magnetohydrodynamics (MHD), has become a central theory in astrophysics, as well as in areas such as engineering and geophysics. This textbook offers a comprehensive introduction to MHD and its recent applications, in nature and in laboratory plasmas; from the machinery of the Sun and galaxies, to the cooling of nuclear reactors and the geodynamo. It exposes advanced undergraduate and graduate students to both classical and modern concepts, making them aware of current research and the ever-widening scope of MHD. Rigorous derivations within the text, supplemented by over 100 illustrations and followed by exercises and worked solutions at the end of each chapter, provide an engaging and practical introduction to the subject and an accessible route into this wide-ranging field.

  17. Introduction to linear elasticity

    CERN Document Server

    Gould, Phillip L

    2013-01-01

    Introduction to Linear Elasticity, 3rd Edition, provides an applications-oriented grounding in the tensor-based theory of elasticity for students in mechanical, civil, aeronautical, and biomedical engineering, as well as materials and earth science. The book is distinct from the traditional text aimed at graduate students in solid mechanics by introducing the subject at a level appropriate for advanced undergraduate and beginning graduate students. The author's presentation allows students to apply the basic notions of stress analysis and move on to advanced work in continuum mechanics, plasticity, plate and shell theory, composite materials, viscoelasticity and finite method analysis. This book also:  Emphasizes tensor-based approach while still distilling down to explicit notation Provides introduction to theory of plates, theory of shells, wave propagation, viscoelasticity and plasticity accessible to advanced undergraduate students Appropriate for courses following emerging trend of teaching solid mechan...

  18. Introduction to Abelian varieties

    CERN Document Server

    Murty, V Kumar

    1993-01-01

    The book represents an introduction to the theory of abelian varieties with a view to arithmetic. The aim is to introduce some of the basics of the theory as well as some recent arithmetic applications to graduate students and researchers in other fields. The first part contains proofs of the Abel-Jacobi theorem, Riemann's relations and the Lefschetz theorem on projective embeddings over the complex numbers in the spirit of S. Lang's book Introduction to algebraic and abelian functions. Then the Jacobians of Fermat curves as well as some modular curves are discussed. Finally, as an application, Faltings' proof of the Mordell conjecture and its intermediate steps, the Tate conjecture and the Shafarevich conjecture, are sketched. - H. Lange for MathSciNet.

  19. Introduction to Sporadic Groups

    Directory of Open Access Journals (Sweden)

    Luis J. Boya

    2011-01-01

    Full Text Available This is an introduction to finite simple groups, in particular sporadic groups, intended for physicists. After a short review of group theory, we enumerate the 1+1+16=18 families of finite simple groups, as an introduction to the sporadic groups. These are described next, in three levels of increasing complexity, plus the six isolated ''pariah'' groups. The (old five Mathieu groups make up the first, smallest order level. The seven groups related to the Leech lattice, including the three Conway groups, constitute the second level. The third and highest level contains the Monster group M, plus seven other related groups. Next a brief mention is made of the remaining six pariah groups, thus completing the 5+7+8+6=26 sporadic groups. The review ends up with a brief discussion of a few of physical applications of finite groups in physics, including a couple of recent examples which use sporadic groups.

  20. Introduction to computer networking

    CERN Document Server

    Robertazzi, Thomas G

    2017-01-01

    This book gives a broad look at both fundamental networking technology and new areas that support it and use it. It is a concise introduction to the most prominent, recent technological topics in computer networking. Topics include network technology such as wired and wireless networks, enabling technologies such as data centers, software defined networking, cloud and grid computing and applications such as networks on chips, space networking and network security. The accessible writing style and non-mathematical treatment makes this a useful book for the student, network and communications engineer, computer scientist and IT professional. • Features a concise, accessible treatment of computer networking, focusing on new technological topics; • Provides non-mathematical introduction to networks in their most common forms today;< • Includes new developments in switching, optical networks, WiFi, Bluetooth, LTE, 5G, and quantum cryptography.

  1. Mind a brief introduction

    CERN Document Server

    Searle, John R

    2004-01-01

    "The philosophy of mind is unique among contemporary philosophical subjects," writes John Searle, "in that all of the most famous and influential theories are false." One of the world's most eminent thinkers, Searle dismantles these theories as he presents a vividly written, comprehensive introduction to the mind. He begins with a look at the twelve problems of philosophy of mind--which he calls "Descartes and Other Disasters"--problems which he returns to throughout the volume, as he illuminates such topics as materialism, consciousness, the mind-body problem, intentionality, mental causation, free will, and the self. The book offers a refreshingly direct and engaging introduction to one of the most intriguing areas of philosophy.

  2. Guest Editor's Introduction

    DEFF Research Database (Denmark)

    Seeberg, Peter

    2015-01-01

    This introductory article’s point of departure is the transformation processes that have taken place in theMiddle East since 2011. It presents perspectives in the academic discussions following the surprising events in a post-‘Arab Spring’ scenario. The Introduction emphasizes that it is the ambi......This introductory article’s point of departure is the transformation processes that have taken place in theMiddle East since 2011. It presents perspectives in the academic discussions following the surprising events in a post-‘Arab Spring’ scenario. The Introduction emphasizes...... that it is the ambition of this collection of articles to discuss and make sense of the significant differences in the developments,where newgeopolitical dynamics reshape theMENA-region’s post-‘Arab Spring’ reality....

  3. Introduction to cosmology

    CERN Document Server

    Roos, Matts

    2015-01-01

    The Fourth Edition of Introduction to Cosmology provides a concise, authoritative study of cosmology at an introductory level. Starting from elementary principles and the early history of cosmology, the text carefully guides the student on to curved spacetimes, special and general relativity, gravitational lensing, the thermal history of the Universe, and cosmological models, including extended gravity models, black holes and Hawking's recent conjectures on the not-so-black holes.

  4. Introduction to group theory

    Directory of Open Access Journals (Sweden)

    Canals B.

    2012-03-01

    Full Text Available This chapter is a concise mathematical introduction into the algebra of groups. It is build up in the way that definitions are followed by propositions and proofs. The concepts and the terminology introduced here will serve as a basis for the following chapters that deal with group theory in the stricter sense and its application to problems in physics. The mathematical prerequisites are at the bachelor level.1

  5. Introduction to superstring theory

    International Nuclear Information System (INIS)

    Nunez, Carmen

    2009-01-01

    This is a very basic introduction to the AdS/CFT correspondence. The first lecture motivates the duality between gauge theories and gravity/string theories. The next two lectures introduce the bosonic and supersymmetric string theories. The fourth lecture is devoted to study Dp-branes and finally, in the fifth lecture I discuss the two worlds: N=4 SYM in 3+1 flat dimensions and type IIB superstrings in AdS 5 x S5. (author)

  6. Introduction to reversible computing

    CERN Document Server

    Perumalla, Kalyan S

    2013-01-01

    Few books comprehensively cover the software and programming aspects of reversible computing. Filling this gap, Introduction to Reversible Computing offers an expanded view of the field that includes the traditional energy-motivated hardware viewpoint as well as the emerging application-motivated software approach. Collecting scattered knowledge into one coherent account, the book provides a compendium of both classical and recently developed results on reversible computing. It explores up-and-coming theories, techniques, and tools for the application of rever

  7. Introduction to contact mechanics

    CERN Document Server

    Fischer-Cripps, Anthony C

    2000-01-01

    Contact mechanics deals with the elastic or plastic contact between two solid objects, and is thus intimately connected with such topics as fracture, hardness, and elasticity.This text, intended for advanced undergraduates, begins with an introduction to the mechanical properties of materials, general fracture mechanics, and fractures in brittle solids.This is followed by a detailed discussion of stresses and the nature of elastic and elastic-plastic contact.

  8. Introduction to minimax

    CERN Document Server

    Dem'yanov, V F; Louvish, D

    2014-01-01

    This user-friendly text offers a thorough introduction to the part of optimization theory that lies between approximation theory and mathematical programming, both linear and nonlinear. Written by two distinguished mathematicians, the expert treatment covers the essentials, incorporating important background materials, examples, and extensive notes.Geared toward advanced undergraduate and graduate students of mathematical programming, the text explores best approximation by algebraic polynomials in both discrete and continuous cases; the discrete problem, with and without constraints; the gene

  9. Introduction to Feynman diagrams

    CERN Document Server

    Bilenky, Samoil Mikhelevich

    1974-01-01

    Introduction to Feynman Diagrams provides Feynman diagram techniques and methods for calculating quantities measured experimentally. The book discusses topics Feynman diagrams intended for experimental physicists. Topics presented include methods for calculating the matrix elements (by perturbation theory) and the basic rules for constructing Feynman diagrams; techniques for calculating cross sections and polarizations; processes in which both leptons and hadrons take part; and the electromagnetic and weak form factors of nucleons. Experimental physicists and graduate students of physics will

  10. Combinatorics an introduction

    CERN Document Server

    Faticoni, Theodore G

    2014-01-01

    Bridges combinatorics and probability and uniquely includes detailed formulas and proofs to promote mathematical thinking Combinatorics: An Introduction introduces readers to counting combinatorics, offers examples that feature unique approaches and ideas, and presents case-by-case methods for solving problems. Detailing how combinatorial problems arise in many areas of pure mathematics, most notably in algebra, probability theory, topology, and geometry, this book provides discussion on logic and paradoxes; sets and set notations; power sets and their cardinality; Venn diagrams; the multip

  11. Introduction to Extra Dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Rizzo, Thomas G.; /SLAC

    2010-04-29

    Extra dimensions provide a very useful tool in addressing a number of the fundamental problems faced by the Standard Model. The following provides a very basic introduction to this very broad subject area as given at the VIII School of the Gravitational and Mathematical Physics Division of the Mexican Physical Society in December 2009. Some prospects for extra dimensional searches at the 7 TeV LHC with {approx}1 fb{sup -1} of integrated luminosity are provided.

  12. Introduction to superstring theory

    Energy Technology Data Exchange (ETDEWEB)

    Nunez, Carmen [Instituto de Astronomia y Fisica del Espacio, Buenos Aires (Argentina)], e-mail: carmen@iafe.uba.ar

    2009-07-01

    This is a very basic introduction to the AdS/CFT correspondence. The first lecture motivates the duality between gauge theories and gravity/string theories. The next two lectures introduce the bosonic and supersymmetric string theories. The fourth lecture is devoted to study Dp-branes and finally, in the fifth lecture I discuss the two worlds: N=4 SYM in 3+1 flat dimensions and type IIB superstrings in AdS{sub 5} x S5. (author)

  13. Introduction to nanotheranostics

    CERN Document Server

    Tamil Selvan, Subramanian

    2016-01-01

    This book offers readers an introduction to the current status of nanoparticles and other nanomaterials that have potential applications in theranostics. Above all, it highlights the diagnostic and therapeutic applications of metallic (e.g. Au, Ag), semiconducting quantum dots (e.g. CdSe, CdTe), magnetic (e.g. Fe3O4, FePt, Co), and multifunctional (combination of two or three) nanoparticles. .

  14. Introduction to biomechatronics

    CERN Document Server

    Brooker, Graham

    2012-01-01

    Introduction to Biomechatronics provides fundamental knowledge of mechanical and electronic (mechatronic) components and systems and their interaction with human biology to assist or replace limbs, senses, and even organs damaged by trauma, birth defects, or disease. The first half of the book provides the engineering background to understand all the components of a biomechatronic system: the human subject, stimulus or actuation, transducers and sensors, signal conditioning elements, recording and display, and feedback elements.

  15. Introduction to electronics

    CERN Document Server

    Korneff, Theodore

    1966-01-01

    Introduction to Electronics focuses on the study of electronics and electronic devices. Composed of 14 chapters, the book starts with discussions on dc circuits, including resistance, voltmeter, ammeter, galvanometer, internal resistance, and positive and negative currents. This topic is followed by discussions on ac circuits, particularly addressing voltage and current, average power, resistive load, complex plane, and parallel circuits. Discussions also focus on filters and tuned circuits, diodes, and power supplies. Particularly given attention are the processes, diagrams, and analyses

  16. Introduction to Accelerators Physics

    International Nuclear Information System (INIS)

    Variola, A.

    2007-01-01

    This short course aims at giving to high energy physics students a preliminary introduction to accelerators basics. The arguments and the style were selected in this perspective. Consequently, topics such as the definition of beam parameters and luminosity were preferred to much more technical aspects. The calculation details were neglected to allow more important highlights on concepts and definitions. Some examples and exercises were suggested to summarize the different topics of the lessons

  17. Introduction to parallel programming

    CERN Document Server

    Brawer, Steven

    1989-01-01

    Introduction to Parallel Programming focuses on the techniques, processes, methodologies, and approaches involved in parallel programming. The book first offers information on Fortran, hardware and operating system models, and processes, shared memory, and simple parallel programs. Discussions focus on processes and processors, joining processes, shared memory, time-sharing with multiple processors, hardware, loops, passing arguments in function/subroutine calls, program structure, and arithmetic expressions. The text then elaborates on basic parallel programming techniques, barriers and race

  18. Introduction to Plasma Physics

    Science.gov (United States)

    Gurnett, Donald A.; Bhattacharjee, Amitava

    2017-03-01

    Preface; 1. Introduction; 2. Characteristic parameters of a plasma; 3. Single particle motions; 4. Waves in a cold plasma; 5. Kinetic theory and the moment equations; 6. Magnetohydrodynamics; 7. MHD equilibria and stability; 8. Discontinuities and shock waves; 9. Electrostatic waves in a hot unmagnetized plasma; 10. Waves in a hot magnetized plasma; 11. Nonlinear effects; 12. Collisional processes; Appendix A. Symbols; Appendix B. Useful trigonometric identities; Appendix C. Vector differential operators; Appendix D. Vector calculus identities; Index.

  19. Introduction to neutron scattering

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, W E [Paul Scherrer Inst. (PSI), Villigen (Switzerland)

    1996-11-01

    We give here an introduction to the theoretical principles of neutron scattering. The relationship between scattering- and correlation-functions is particularly emphasized. Within the framework of linear response theory (justified by the weakness of the basic interaction) the relation between fluctuation and dissipation is discussed. This general framework explains the particular power of neutron scattering as an experimental method. (author) 4 figs., 4 refs.

  20. Semiconductor Manufacturing equipment introduction

    International Nuclear Information System (INIS)

    Im, Jong Sun

    2001-02-01

    This book deals with semiconductor manufacturing equipment. It is comprised of nine chapters, which are manufacturing process of semiconductor device, history of semiconductor manufacturing equipment, kinds and role of semiconductor manufacturing equipment, construction and method of semiconductor manufacturing equipment, introduction of various semiconductor manufacturing equipment, spots of semiconductor manufacturing, technical elements of semiconductor manufacturing equipment, road map of technology of semiconductor manufacturing equipment and semiconductor manufacturing equipment in the 21st century.

  1. Introduction to heat transfer

    CERN Document Server

    SUNDÉN, B

    2012-01-01

    Presenting the basic mechanisms for transfer of heat, Introduction to Heat Transfer gives a deeper and more comprehensive view than existing titles on the subject. Derivation and presentation of analytical and empirical methods are provided for calculation of heat transfer rates and temperature fields as well as pressure drop. The book covers thermal conduction, forced and natural laminar and turbulent convective heat transfer, thermal radiation including participating media, condensation, evaporation and heat exchangers.

  2. Accounting Applications---Introduction

    OpenAIRE

    Joshua Ronen

    1980-01-01

    Introduction to special issue on accounting applications. By publishing these papers together in one issue of Management Science we wish to accomplish the dual purpose of exposing management scientists to the application of their discipline to important accounting problems and of allowing management scientists and accountants to interact in areas of research and problem-solving, thus stimulating the interest of readers who are concerned with the problems of accounting.

  3. Introduction: Persistent Modelling

    DEFF Research Database (Denmark)

    Ayres, Phil

    2012-01-01

    This introduction to 'Persistent Modelling – an extended role for architectural representation' identifies how the book probes the relationship between representation and the represented, in an architectural context. It discusses how the book presents an examination and discussion of historical......, familiar contemporary and, perhaps, not so familiar emerging manifestations of this relation. What persists from this probing, fully intact, is that representation and the represented remain inextricably related in our contemporary and emerging practices. What comes into focus is that the nature...

  4. Ion implantation - an introduction

    International Nuclear Information System (INIS)

    Townsend, P.D.

    1986-01-01

    Ion implantation is a widely used technique with a literature that covers semiconductor production, surface treatments of steels, corrosion resistance, catalysis and integrated optics. This brief introduction outlines advantages of the technique, some aspects of the underlying physics and examples of current applications. Ion implantation is already an essential part of semiconductor technology while in many other areas it is still in an early stage of development. The future scope of the subject is discussed. (author)

  5. Introduction to analytical mechanics

    CERN Document Server

    Gamalath, KAILW

    2011-01-01

    INTRODUCTION TO ANALYTICAL MECHANICS is an attempt to introduce the modern treatment of classical mechanics so that transition to many fields in physics can be made with the least difficulty. This book deal with the formulation of Newtonian mechanics, Lagrangian dynamics, conservation laws relating to symmetries, Hamiltonian dynamics Hamilton's principle, Poisson brackets, canonical transformations which are invaluable in formulating the quantum mechanics and Hamilton-Jacobi equation which provides the transition to wave mechanics.

  6. Introduction to QCD

    OpenAIRE

    Skands, Peter

    2012-01-01

    These lectures were originally given at TASI and are directed at a level suitable for graduate students in High Energy Physics. They are intended to give an introduction to the theory and phenomenology of quantum chromodynamics (QCD), focusing on collider physics applications. The aim is to bring the reader to a level where informed decisions can be made concerning different approaches and their uncertainties. The material is divided into five main areas: 1) fundamentals, 2) fixed-order pertu...

  7. Introduction to Q

    International Nuclear Information System (INIS)

    Kellogg, M.; Minor, M.M.; Shlaer, S.; Spencer, N.; Thomas, R.F. Jr.; van der Beken, H.

    1978-06-01

    This manual presents an overview of the Q data-acquisition system. Its purposes are to assist an experimenter in determining whether the system is suited to his needs and to provide an introduction to the more detailed manuals. This system employs a powerful technique for dealing with multiprocessor systems by generating code and communication protocol for two processors from a single source program in a high-level language. Some details of experimental event buffering and distribution are discussed

  8. Introduction to abstract algebra

    CERN Document Server

    Nicholson, W Keith

    2012-01-01

    Praise for the Third Edition ". . . an expository masterpiece of the highest didactic value that has gained additional attractivity through the various improvements . . ."-Zentralblatt MATH The Fourth Edition of Introduction to Abstract Algebra continues to provide an accessible approach to the basic structures of abstract algebra: groups, rings, and fields. The book's unique presentation helps readers advance to abstract theory by presenting concrete examples of induction, number theory, integers modulo n, and permutations before the abstract structures are defined. Readers can immediately be

  9. Introduction to microfabrication

    CERN Document Server

    Franssila, Sami

    2005-01-01

    Microfabrication is the key technology behind integrated circuits, microsensors, photonic crystals, ink jet printers, solar cells and flat panel displays. Microsystems can be complex, but the basic microstructures and processes of microfabrication are fairly simple. Introduction to Microfabrication shows how the common microfabrication concepts can be applied over and over again to create devices with a wide variety of structures and functions.Featuring:* A comprehensive presentation of basic fabrication processes* An emphasis on materials and microstructures, rather than devic

  10. Modular relations for the Rogers-Ramanujan-Slater type functions of order fifteen and its applications to partitions

    Directory of Open Access Journals (Sweden)

    Chandrashekar Adiga

    2013-10-01

    Full Text Available In a manuscript of Ramanujan, published with his Lost Notebook [20] there are forty identities involving the Rogers-Ramanujan functions. In this paper, we establish several modular relations involving the Rogers-Ramanujan functions and the Rogers-Ramanujan-Slater type functions of order fifteen which are analogues to Ramanujan’s well known forty identities. Furthermore, we give partition theoretic interpretations of two modular relations.

  11. A QUANTITATIVE STUDY OF α-SYNUCLEIN PATHOLOGY IN FIFTEEN CASES OF DEMENTIA ASSOCIATED WITH PARKINSON DISEASE

    OpenAIRE

    Armstrong, Richard A.; Kotzbauer, Paul T.; Perlmutter, Joel S.; Campbell, Meghan C.; Hurth, Kyle M.; Schmidt, Robert E.; Cairns, Nigel J.

    2013-01-01

    The α-synuclein-immunoreactive pathology of dementia associated with Parkinson disease (DPD) comprises Lewy bodies (LB), Lewy neurites (LN), and Lewy grains (LG). The densities of LB, LN, LG together with vacuoles, neurons, abnormally enlarged neurons (EN), and glial cell nuclei were measured in fifteen cases of DPD. Densities of LN and LG were up to 19 and 70 times those of LB respectively, depending on region. Densities were significantly greater in amygdala, entorhinal cortex (EC), and sec...

  12. PHEV Market Introduction Workshop Summary Report

    Energy Technology Data Exchange (ETDEWEB)

    Weber, Adrienne M [ORNL; Sikes, Karen R [ORNL

    2009-03-01

    The Plug-In Hybrid Electric Vehicle (PHEV) Market Introduction Study Workshop was attended by approximately forty representatives from various stakeholder organizations. The event took place at the Hotel Helix in Washington, D.C. on December 1-2, 2008. The purpose of this workshop was to follow-up last year s PHEV Value Proposition Study, which showed that indeed, a viable and even thriving market for these vehicles can exist by the year 2030. This workshop aimed to identify immediate action items that need to be undertaken to achieve a successful market introduction and ensuing large market share of PHEVs in the U.S. automotive fleet.

  13. The Fifteen Oes, the "Disticha Catonis," Marculfius, and Dick, Jane, and Sally

    Science.gov (United States)

    Noakes, Susan

    1977-01-01

    Available from: University of Chicago Library Society Bulletin, c/o Harriet Clouse, Library Development Office, Regenstein Library, University of Chicago, Chicago, Illinois; $7.50 per year; issued irregularly 2-3/year. Discusses late-medieval primary education, especially learning to read; indicates how such education affected the way adults used…

  14. Introduction to the ROOT System

    CERN Multimedia

    CERN. Geneva

    2008-01-01

    Introduction to the ROOT data handling system. ROOT is used in some for or another by all LHC experiments and will be used by all for final data analysis. The introduction gives an overview of the system. Prerequisite knowledge: C++

  15. Introduction to Artificial Neural Networks

    DEFF Research Database (Denmark)

    Larsen, Jan

    1999-01-01

    The note addresses introduction to signal analysis and classification based on artificial feed-forward neural networks.......The note addresses introduction to signal analysis and classification based on artificial feed-forward neural networks....

  16. Human drug metabolism: an introduction

    National Research Council Canada - National Science Library

    Coleman, Michael D

    2010-01-01

    Human Drug Metabolism, An Introduction, Second Edition provides an accessible introduction to the subject and will be particularly invaluable to those who already have some understanding of the life sciences...

  17. Introduction to laser technology

    CERN Document Server

    Hitz, C Breck; Hecht, Jeff; Hitz, C Breck; John Wiley & Sons

    2001-01-01

    Electrical Engineering Introduction to Laser Technology , Third Edition. Would you like to know how a laser works, and how it can be modified for your own specific tasks? This intuitive third edition-previously published as Understanding Laser Technology , First and Second Editions-introduces engineers, scientists, technicians, and novices alike to the world of modern lasers, without delving into the mathematical details of quantum electronics. It is the only introductory text on the market today that explains the underlying physics and engineering applicable to all lasers. A unique combinatio.

  18. Introduction to applied thermodynamics

    CERN Document Server

    Helsdon, R M; Walker, G E

    1965-01-01

    Introduction to Applied Thermodynamics is an introductory text on applied thermodynamics and covers topics ranging from energy and temperature to reversibility and entropy, the first and second laws of thermodynamics, and the properties of ideal gases. Standard air cycles and the thermodynamic properties of pure substances are also discussed, together with gas compressors, combustion, and psychrometry. This volume is comprised of 16 chapters and begins with an overview of the concept of energy as well as the macroscopic and molecular approaches to thermodynamics. The following chapters focus o

  19. Introduction to cosmology

    CERN Document Server

    Roos, Matts

    2003-01-01

    The Third Edition of the hugely successful Introduction to Cosmology provides a concise, authoritative study of cosmology at an introductory level. Starting from elementary principles and the history of cosmology, the text carefully guides the student on to curved spacetimes, general relativity, black holes, cosmological models, particles and symmetries, and phase transitions. Extensively revised, this latest edition includes broader and updated coverage of distance measures, gravitational lensing and waves, dark energy and quintessence, the thermal history of the Universe, inflation,

  20. Introduction to real analysis

    CERN Document Server

    Schramm, Michael J

    2008-01-01

    This text forms a bridge between courses in calculus and real analysis. It focuses on the construction of mathematical proofs as well as their final content. Suitable for upper-level undergraduates and graduate students of real analysis, it also provides a vital reference book for advanced courses in mathematics.The four-part treatment begins with an introduction to basic logical structures and techniques of proof, including discussions of the cardinality concept and the algebraic and order structures of the real and rational number systems. Part Two presents in-depth examinations of the compl

  1. Fourier analysis an introduction

    CERN Document Server

    Stein, Elias M

    2003-01-01

    This first volume, a three-part introduction to the subject, is intended for students with a beginning knowledge of mathematical analysis who are motivated to discover the ideas that shape Fourier analysis. It begins with the simple conviction that Fourier arrived at in the early nineteenth century when studying problems in the physical sciences--that an arbitrary function can be written as an infinite sum of the most basic trigonometric functions.The first part implements this idea in terms of notions of convergence and summability of Fourier series, while highlighting applications such as th

  2. Introduction to dynamic programming

    CERN Document Server

    Cooper, Leon; Rodin, E Y

    1981-01-01

    Introduction to Dynamic Programming provides information pertinent to the fundamental aspects of dynamic programming. This book considers problems that can be quantitatively formulated and deals with mathematical models of situations or phenomena that exists in the real world.Organized into 10 chapters, this book begins with an overview of the fundamental components of any mathematical optimization model. This text then presents the details of the application of dynamic programming to variational problems. Other chapters consider the application of dynamic programming to inventory theory, Mark

  3. Introduction to Heat Pipes

    Science.gov (United States)

    Ku, Jentung

    2015-01-01

    This is the presentation file for the short course Introduction to Heat Pipes, to be conducted at the 2015 Thermal Fluids and Analysis Workshop, August 3-7, 2015, Silver Spring, Maryland. NCTS 21070-15. Course Description: This course will present operating principles of the heat pipe with emphases on the underlying physical processes and requirements of pressure and energy balance. Performance characterizations and design considerations of the heat pipe will be highlighted. Guidelines for thermal engineers in the selection of heat pipes as part of the spacecraft thermal control system, testing methodology, and analytical modeling will also be discussed.

  4. An introduction to optimization

    CERN Document Server

    Chong, Edwin K P

    2013-01-01

    Praise for the Third Edition "". . . guides and leads the reader through the learning path . . . [e]xamples are stated very clearly and the results are presented with attention to detail.""  -MAA Reviews  Fully updated to reflect new developments in the field, the Fourth Edition of Introduction to Optimization fills the need for accessible treatment of optimization theory and methods with an emphasis on engineering design. Basic definitions and notations are provided in addition to the related fundamental background for linear algebra, geometry, and calculus.  This new

  5. Introduction to continuum mechanics

    CERN Document Server

    Lai, W Michael; Rubin, David

    1996-01-01

    Introduction to Continuum Mechanics is a recently updated and revised text which is perfect for either introductory courses in an undergraduate engineering curriculum or for a beginning graduate course.Continuum Mechanics studies the response of materials to different loading conditions. The concept of tensors is introduced through the idea of linear transformation in a self-contained chapter, and the interrelation of direct notation, indicial notation, and matrix operations is clearly presented. A wide range of idealized materials are considered through simple static and dynamic problems, a

  6. Cartesian tensors an introduction

    CERN Document Server

    Temple, G

    2004-01-01

    This undergraduate text provides an introduction to the theory of Cartesian tensors, defining tensors as multilinear functions of direction, and simplifying many theorems in a manner that lends unity to the subject. The author notes the importance of the analysis of the structure of tensors in terms of spectral sets of projection operators as part of the very substance of quantum theory. He therefore provides an elementary discussion of the subject, in addition to a view of isotropic tensors and spinor analysis within the confines of Euclidean space. The text concludes with an examination of t

  7. Introduction to cluster dynamics

    CERN Document Server

    Reinhard, Paul-Gerhard

    2008-01-01

    Clusters as mesoscopic particles represent an intermediate state of matter between single atoms and solid material. The tendency to miniaturise technical objects requires knowledge about systems which contain a ""small"" number of atoms or molecules only. This is all the more true for dynamical aspects, particularly in relation to the qick development of laser technology and femtosecond spectroscopy. Here, for the first time is a highly qualitative introduction to cluster physics. With its emphasis on cluster dynamics, this will be vital to everyone involved in this interdisciplinary subje

  8. Introduction to superconductivity

    CERN Document Server

    Rose-Innes, A C

    1978-01-01

    Introduction to Superconductivity differs from the first edition chiefly in Chapter 11, which has been almost completely rewritten to give a more physically-based picture of the effects arising from the long-range coherence of the electron-waves in superconductors and the operation of quantum interference devices. In this revised second edition, some further modifications have been made to the text and an extra chapter dealing with """"high-temperature"""" superconductors has been added. A vast amount of research has been carried out on these since their discovery in 1986 but the results, both

  9. Introduction to information retrieval

    CERN Document Server

    Manning, Christopher D; Schütze, Hinrich

    2008-01-01

    Class-tested and coherent, this textbook teaches classical and web information retrieval, including web search and the related areas of text classification and text clustering from basic concepts. It gives an up-to-date treatment of all aspects of the design and implementation of systems for gathering, indexing, and searching documents; methods for evaluating systems; and an introduction to the use of machine learning methods on text collections. All the important ideas are explained using examples and figures, making it perfect for introductory courses in information retrieval for advanced un

  10. Introduction to Econophysics

    Science.gov (United States)

    Mantegna, Rosario N.; Stanley, H. Eugene

    2007-08-01

    Preface; 1. Introduction; 2. Efficient market hypothesis; 3. Random walk; 4. Lévy stochastic processes and limit theorems; 5. Scales in financial data; 6. Stationarity and time correlation; 7. Time correlation in financial time series; 8. Stochastic models of price dynamics; 9. Scaling and its breakdown; 10. ARCH and GARCH processes; 11. Financial markets and turbulence; 12. Correlation and anti-correlation between stocks; 13. Taxonomy of a stock portfolio; 14. Options in idealized markets; 15. Options in real markets; Appendix A: notation guide; Appendix B: martingales; References; Index.

  11. Theoretical astrophysics an introduction

    CERN Document Server

    Bartelmann, Matthias

    2013-01-01

    A concise yet comprehensive introduction to the central theoretical concepts of modern astrophysics, presenting hydrodynamics, radiation, and stellar dynamics all in one textbook. Adopting a modular structure, the author illustrates a small number of fundamental physical methods and principles, which are sufficient to describe and understand a wide range of seemingly very diverse astrophysical phenomena and processes. For example, the formulae that define the macroscopic behavior of stellar systems are all derived in the same way from the microscopic distribution function. This function it

  12. Introduction to spectral theory

    CERN Document Server

    Levitan, B M

    1975-01-01

    This monograph is devoted to the spectral theory of the Sturm- Liouville operator and to the spectral theory of the Dirac system. In addition, some results are given for nth order ordinary differential operators. Those parts of this book which concern nth order operators can serve as simply an introduction to this domain, which at the present time has already had time to become very broad. For the convenience of the reader who is not familar with abstract spectral theory, the authors have inserted a chapter (Chapter 13) in which they discuss this theory, concisely and in the main without proofs, and indicate various connections with the spectral theory of differential operators.

  13. Introduction to mathematical logic

    CERN Document Server

    Mendelson, Elliott

    2015-01-01

    The new edition of this classic textbook, Introduction to Mathematical Logic, Sixth Edition explores the principal topics of mathematical logic. It covers propositional logic, first-order logic, first-order number theory, axiomatic set theory, and the theory of computability. The text also discusses the major results of Gödel, Church, Kleene, Rosser, and Turing.The sixth edition incorporates recent work on Gödel's second incompleteness theorem as well as restoring an appendix on consistency proofs for first-order arithmetic. This appendix last appeared in the first edition. It is offered in th

  14. An introduction to cosmology

    CERN Document Server

    Narlikar, Jayant Vishnu

    2002-01-01

    The third edition of this successful textbook is fully updated and includes important recent developments in cosmology. It begins with an introduction to cosmology and general relativity, and goes on to cover the mathematical models of standard cosmology. The physical aspects of cosmology, including primordial nucleosynthesis, the astroparticle physics of inflation, and the current ideas on structure formation are discussed. Alternative models of cosmology are reviewed, including the model of Quasi-Steady State Cosmology, which has recently been proposed as an alternative to Big Bang Cosmology.

  15. Introduction to cardinal arithmetic

    CERN Document Server

    Holz, M; Weitz, E

    1999-01-01

    This book is an introduction into modern cardinal arithmetic in the frame of the axioms of Zermelo-Fraenkel set theory together with the axiom of choice (ZFC). A first part describes the classical theory developed by Bernstein, Cantor, Hausdorff, König and Tarski between 1870 and 1930. Next, the development in the 1970s led by Galvin, Hajnal and Silver is characterized. The third part presents the fundamental investigations in pcf theory which have been worked out by Shelah to answer the questions left open in the 1970s.Reviews:'The authors aim their text at beginners in set theory. They start

  16. Introduction to EMC

    CERN Document Server

    Scott, John

    1997-01-01

    This is the clear guide for non-specialists to electromagnetic compatability (EMC), the effects of electromagnetic radiation and the European EMC Directive which is now in force. This book helps by explaining the basic principles of EMC, how it may be controlled in practice through filtering, shielding, appropriate printed circuit board design, and other means. Electrostatic discharge (ESD) and surge protection are discussed. The growing concern about the effects of electromagnetic waves and fields on health are examined in detail.This introduction provides beginners, technical and

  17. Introduction to superconductivity

    CERN Document Server

    Darriulat, Pierre

    1998-01-01

    The lecture series will address physicists, such as particle and nuclear physicists, familiar with non-relativistic quantum mechanics but not with solid state physics. The aim of this introduction to low temperature superconductivity is to give sufficient bases to the student for him/her to be able to access the scientific literature on this field. The five lectures will cover the following topics : 1. Normal metals, free electron gas, chambers equation. 2. Cooper pairs, the BCS ground state, quasi particle excitations. 3. DC superconductivity, Meissner state, dirty superconductors.4. Self consistent approach, Ginsburg Landau equations, Abrikosov fluxon lattice. 5. Josephson effects, high temperature superconductivity.

  18. Introduction to combinatorial designs

    CERN Document Server

    Wallis, WD

    2007-01-01

    Combinatorial theory is one of the fastest growing areas of modern mathematics. Focusing on a major part of this subject, Introduction to Combinatorial Designs, Second Edition provides a solid foundation in the classical areas of design theory as well as in more contemporary designs based on applications in a variety of fields. After an overview of basic concepts, the text introduces balanced designs and finite geometries. The author then delves into balanced incomplete block designs, covering difference methods, residual and derived designs, and resolvability. Following a chapter on the e

  19. Statistics a biomedical introduction

    CERN Document Server

    Brown, Byron Wm

    2009-01-01

    CHAPTER 1: Introduction 1 CHAPTER 2: Elementary Rules of Probability 13 CHAPTER 3: Populations, Samples, and the Distribution of the Sample Mean 37 1. Populations and Distributions 38 2. Sampling from Finite Populations 64 3. The Distribution of the Sample Mean 72 CHAPTER 4: Analysis of Matched Pairs Using Sample Means 85 1. A Confidence Interval for the Treatment Effect 86 2. A Hypothesis Test for the Treatment Effect 96 3. Determining the Sample Size 102 CHAPTER 5: Analysis of the Two-Sample Location Problem Using Sample Means 109 1. A Confidence Interval for the Diffe

  20. Game Theory An Introduction

    CERN Document Server

    Barron, E N

    2008-01-01

    A fundamental introduction to modern game theory from a mathematical viewpoint. Game theory arises in almost every fact of human and inhuman interaction since oftentimes during these communications objectives are opposed or cooperation is viewed as an option. From economics and finance to biology and computer science, researchers and practitioners are often put in complex decision-making scenarios, whether they are interacting with each other or working with evolving technology and artificial intelligence. Acknowledging the role of mathematics in making logical and advantageous decisions, Game