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Sample records for intramuscular um importante

  1. Triacilglicerol intramuscular: um importante substrato energético para o exercício de endurance Triacilglicerol intramuscular: un importante substrato energético para el ejercicio de endurance Intramuscular triacylglycerol: an important energetic substrate for endurance exercise

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    Mônica Aparecida Belmonte

    2005-04-01

    Full Text Available Os ácidos graxos são uma importante fonte de energia para exercício de endurance. Os ácidos graxos plasmáticos encontram-se disponíveis para as fibras musculares sob a forma de ácidos graxos associados à albumina ou agregados à molécula de triacilglicerol (TAG encontrada nas lipoproteínas. Entretanto, além dessas fontes plasmáticas, a hidrólise do TAG encontrado no músculo também pode contribuir com a oferta de ácidos graxos durante o exercício de endurance. O objetivo do presente trabalho foi realizar uma extensa revisão da literatura sobre a importância do TAG intramuscular como substrato energético. A revisão da literatura sugere que a contribuição dos estoques endógenos de TAG durante a realização do exercício de endurance é bastante relevante. Além disso, pode-se concluir que uma adaptação induzida pelo treinamento de endurance é o aumento dos estoques intramusculares de TAG. Após o treinamento de endurance, também é observado aumento na capacidade de utilização desses estoques. Apesar de parecer importante, a contribuição do TAG intramuscular ainda é motivo de controvérsia na literatura. Essa discrepância de resultados está relacionada às metodologias empregadas para estimar a sua oxidação no exercício. A fim de esgotar este assunto de maneira apropriada, mais pesquisas, com novos métodos (ex.: utilização de isótopos, ressonância magnética nuclear e microscopia eletrônica, precisam ser conduzidas.Los ácidos grasos son una fuente importante de energía para el ejercicio de endurance. Los ácidos grasos plasmáticos se encuentran disponibles en las fibras musculares bajo la forma de ácido graso asociado a la albúmina o agregados a la molécula del triacilglicerol (TAG encontrados en las lipoproteínas. Sin embargo, además de estos fuentes plasmáticas, la hidrólisis de los TAG encontrados en el músculo pueden contribuir también con la oferta de ácidos grasos durante el ejercicio

  2. Curdlan: an important microbial hydrocolloid/ Goma curdlana: um importante hidrocolóide microbiano

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    Elaine Soares Amorim

    2003-05-01

    Full Text Available The use of gums in the food industry is mainly based in its functional properties, which are related to the capacity to prevent or delay a series of physicals phenomenon, having an important role in the stability of many industrialized food. The use of these in the several food productions is indispensable, because they contribute to thickening, gelling, stabilization, suspension, film formation and gums can act as auxiliary agents of processing. Therefore, our objective was evaluated the chemistries physical properties, as well as, the areas of application of the microbial hydrocolloid, curdlan.O uso das gomas na indústria de alimentos baseia-se principalmente no aproveitamento de suas propriedades funcionais, que estão relacionadas à capacidade de prevenir ou retardar uma série de fenômenos físicos, desempenhando papel importante na estabilidade de muitos alimentos industrializados. É indispensável o uso destas na produção de diversos produtos alimentícios, pois contribuem para o espessamento, gelificação, estabilização, suspensão, formação de filme e podem atuar como agentes auxiliares de processamento. Desta forma, o presente trabalho buscou avaliar as propriedades físico-químicas, bem como, as áreas de aplicação da goma curdlana que é um hidrocolóide de origem microbiana.

  3. “Pós de doliarina e ferro”: um dos remédios importantes da Farmácia Peckolt

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    Fábio Teixeira da Silva

    2015-12-01

    Full Text Available Resumo O farmacêutico Theodoro Peckolt é uma das mais importantes figuras da história da química de produtos naturais brasileira. Como outros farmacêuticos do século XIX que atuavam no Brasil, desenvolveu formulações que comercializava em sua farmácia, localizada no Rio de Janeiro, e que tiveram grande prestígio junto à população e à classe médica. O texto apresenta a relação entre a doença identificada inicialmente como opilação e a terapêutica utilizada no século XIX, destacando uma das formulações da Farmácia Peckolt – “Pós de doliarina e ferro”. O produto tem sua origem no látex da espécie Ficus gomelleira(figueira-branca ou gameleira. O artigo tem entre seus objetivos revelar a composição química, feita por métodos modernos de análise do látex deFicus gomelleira.

  4. Chlamydia trachomatis: um importante agente de infecções respiratórias em lactentes de famílias de baixa renda

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    Edna Lucia Souza

    2012-10-01

    Full Text Available OBJETIVOS: Determinar a prevalência de infecção do trato respiratório inferior (ITRI por Chlamydia trachomatis em lactentes internados e descrever as características clínicas, laboratoriais e radiológicas da doença. MÉTODOS: Este foi um estudo do tipo corte transversal, realizado durante um período de 12 meses. Foram incluídos todos os lactentes de até 6 meses internados consecutivamente no Centro Pediátrico Professor Hosannah de Oliveira da Universidade Federal da Bahia, em Salvador, BA, com diagnóstico clínico ou clínico-radiológico de ITRI. O diagnóstico de infecção por C. trachomatis foi realizado através da pesquisa de anticorpos da classe IgM, utilizando-se o ensaio imunoenzimático (ELISA. A prevalência de ITRI por C. trachomatis foi determinada, e foram calculadas as razões de prevalência para essa infecção e variáveis clínicas e laboratoriais. RESULTADOS: Cento e cinquenta e um lactentes realizaram sorologia para C. trachomatis, das quais 15 (9,9% foram positivas. A infecção por C. trachomatis ocorreu unicamente entre os menores de 5 meses, principalmente naqueles menores de 2 meses. Três crianças com infecção por C. trachomatis nasceram de parto cesáreo. Conjuntivite e eosinofilia ocorreram em 33,3% dos casos. As radiografias de tórax se mostraram alteradas em 92% dos casos. Demonstrou-se associação da infecção por C. trachomatis com duração de internação superior a 15 dias (p = 0,0398 e com oxigenoterapia (p = 0,0484. CONCLUSÕES: Houve alta prevalência de ITRI por C. trachomatis na população estudada. A infecção por esta bactéria foi associada a uma forma mais grave da doença, demonstrando a importância de se investigar essa infecção na gestante de forma a evitar o adoecimento de recém-nascidos.

  5. Matriz Metaloproteinase 2: um importante marcador genético para colesteatomas Matrix Metalloproteinase 2: an important genetic marker for cholesteatomas

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    Douglas Salmazo Rocha Morales

    2007-02-01

    Full Text Available Este estudo foi desenvolvido para determinar a presença de MMP2 em colesteatomas humanos e observar se colesteatomas que complicam (invasivos apresentam uma maior expressão imunohistoquímica de Matriz Metaloproteinase 2 (MMP2. Colesteatomas produzem enzimas que causam erosão óssea, como a MMP2. MATERIAL E MÉTODO: Analisamos a expressão imunohistoquímica de MMP2 em colesteatomas invasivos, comparando-os aos latentes. Um estudo de corte transversal com dezenove lâminas e blocos parafinados de colesteatoma, derivados de mastoidectomias, foram desparafinados e submetidos à técnica imunohistoquímica com anticorpos anti-MMP2. RESULTADOS: Os resultados foram expressos em 0 (tênue, + (leve, ++ (moderado e +++ (intenso, de acordo com a intensidade da expressão de MMP2. As expressões 0 e + foram denominadas Fraca e as expressões ++ e +++, Forte. Dos 8 colesteatomas invasivos, 7 apresentaram Forte expressão de MMP2 (87,5%. Com relação aos colesteatomas latentes (11, apenas 3 apresentaram Forte expressão de MMP2 (27,3%, com um teste exato de Fisher significante (p= 0,015. CONCLUSÃO: Colesteatomas expressam MMP2 e colesteatomas invasivos expressam MMP2 com maior intensidade, em relação aos latentes.AIM: This study is to determine the MMP2’s presence in cholesteatomas and whether complicating cholesteatomas show a higher immunohistochemical expression of matrix metalloproteinase 2. Cholesteatoma produces enzymesthat cause bone erosion like Matrixmetalloproteinase 2 (MMP2. MATERIAL AND METHODS: We analyzed the expression of MMP2 in invasive (causing complications compared to latent cholesteatomas (not causing complications. A crosssectional study with nineteen slides and paraffin blocks of cholesteatomas derived from mastoidectomies were located and processed, including 8 invasive and 11 latent cholesteatomas. Immunohistochemical thecnique was empregated to MMP2. RESULTS: The results are expressed as 0, + (to low, ++ and +++(high

  6. Intramuscular plasmacytoma

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    Surov, Alexey [Martin-Luther-University of Halle-Wittenberg, Department of Radiology, Halle (Saale) (Germany); Tcherkes, Anatolij [Martin-Luther-University of Halle-Wittenberg, Department of Hematology/Oncology, Halle (Saale) (Germany); Meier, Frieder [Martin-Luther-University of Halle-Wittenberg, Department of Pathology, Halle (Saale) (Germany)

    2014-11-15

    In multiple myeloma, secondary infiltration of adjacent muscles from bone lesions is common. However, plasmacytoma directly arising within the skeletal musculature is rare. Imaging findings of this rare entity have been described only sporadically. The purpose of this study was to identify the clinical signs and radiological features of intramuscular plasmacytoma (IP). Eleven patients with IP were retrospectively identified in the pathological and radiological databases of our institution. Computed tomography (CT) was performed in nine patients and magnetic resonance imaging (MRI) in four cases. IP presented clinically with local pain in four patients. In one case with involvement of the rectus lateralis muscle of the eye, the patient showed a painless bulbus proptosis. In another patient, IP manifested as a massive bilateral forearm swelling with compartment syndrome. In four patients, IP was identified incidentally on computed tomography during staging examination. On imaging, two patterns of IP were found: intramuscular mass (n = 5) or diffuse muscle infiltration (n = 6). On CT with contrast, IP showed a moderate enhancement. With MRI on T1-weighted images, IP was isointense in comparison to the unaffected musculature, whereas on T2-weighted images, IP showed high signal intensity. After intravenous administration of contrast medium, a slight-to-moderate inhomogeneous enhancement was seen in all cases. IP should be considered in the differential diagnosis of muscle tumors. It manifests with two radiological patterns, either as intramuscular mass or as diffuse muscle infiltration. (orig.)

  7. Como encontrar as palavras-chave mais importantes de um corpus com WordSmith tools How to find the most important keywords in a corpus with WordSmith tools

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    Tony Berber-Sardinha

    2005-12-01

    Full Text Available Um dos procedimentos mais delicados envolvidos numa análise de corpus via palavras-chave com WordSmith Tools KeyWords é a seleção de um sub-conjunto de palavras para serem investigadas em detalhe. A seleção se faz necessária, via de regra, porque o tamanho do léxico chave de um corpus de estudo é em geral muito grande, em geral em torno de 1500 palavras ou até mais. Uma maneira de fazer esse recorte consiste na extração de palavras-chave exclusivas. O léxico chave exclusivo é composto das palavras-chave que ocorrem somente no corpus de estudo em questão em comparação com palavras-chave de outros corpora de estudo. Contudo, comparar a lista de palavras-chave com várias outras é um procedimento custoso e complicado, que não pode ser exigido da maioria dos usuários de WordSmith Tools KeyWords. Uma alternativa para este cenário seria a aplicação de um ponto de corte generalizado baseado em tendências de retorno de palavras-chave observadas através da aplicação do banco de palavras-chave existente. Tal ponto de corte indicaria a região da lista de palavras-chave na qual há maior probabilidade de ocorrência do léxico chave exclusivo. Os resultados obtidos aqui indicam um ponto de corte entre 31% a 53% das palavras da lista, a partir da primeira de uma lista ordenada por chavicidade.One of the most sensitive issues surrounding a keywords analysis with WordSmith Tools is the selection of a subset of words in a corpus that deserve being looked at in greater detail. This selection is normally needed because the size of the key word list can reach several hundred, up to 1,500 or more. One way to extract a selection consists of the pulling out 'exclusive key words'. This key lexis is made up of keywords that only in a single corpus only, in comparison with a bank of keyword lists. Nevertheless, comparing several keyword lists together is a demanding task, which most users of WordSmith Tools are not expected to cope with. An

  8. Disseleneto de difenila: Um organocalcogênio com baixa toxicidade em não roedores e importantes propriedades anti-aterogênicas em modelos in vivo e in vitro

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    Andreza Fabro de Bem

    2007-01-01

    A aterosclerose é uma condição inflamatória crônica associada à produção de espécies oxidantes. A oxidação da lipoproteína de baixa densidade (LDL) parece ter um papel fundamental na patogênese da aterosclerose, desta forma os antioxidantes, substâncias capazes de inibir o processo oxidativo, podem ser úteis na prevenção das condições patológicas associadas à aterosclerose, como doenças cardiovasculares e acidentes vasculares cerebrais. Nesta tese, investigou-se os potenciais efeitos to...

  9. Micronúcleo: um importante marcador biológico intermediário na prevenção do câncer bucal =Micronuclei: an important intermediate biomarker on oral cancer prevention

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    Andrade, Miguel Gustavo Setúbal et al.

    2005-01-01

    Full Text Available A preocupação com a prevenção do câncer da boca e da orofaringe tem motivado diversos estudos epidemiológicos que, apesar de serem úteis em identificar fatores de risco, os indivíduos da amostra já tinham desenvolvido a neoplasia maligna. Outros estudos são conduzidos para investigar a incidência de leucoplasias e segundo tumor primário em indivíduos submetidos a um determinado agente de prevenção. Nesses estudos, entretanto, as alterações celulares são constatadas num momento avançado. Este trabalho se propõe a discutir o papel do micronúcleo, uma alteração cromossômica capaz de refletir a exposição dos indivíduos a carcinógenos, como marcador biológico intermediário na prevenção do câncer bucal e na avaliação de estudos prospectivos. The concern with the prevention of mouth and oropharynx cancer has motivated epidemiological studies that, although useful on identify risk factors, the individuals of the sample had already developed the malignant neoplasia. Other studies are lead to verify the incidence of leucoplasias and second primary tumors in individuals submitted to a specific prevention agent. In these studies, however, cellular alterations are evidenced at an advanced stage. This work is proposed to argue the role of micronuclei, a chromosomal alteration able to reflect carcinogen exposition of an individual, as intermediate biomarker in the prevention of oral cancer and in the evaluation of prospective studies.

  10. Diclofenaco intramuscular no tratamento agudo da migrânea: um estudo duplo cego placebo controlado Intramuscular diclofenac in the acute treatment of migraine: a double-blind placebo controlled study

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    Marcelo E. Bigal

    2002-06-01

    Full Text Available O objetivo do presente estudo é avaliar, com mascaramento duplo, o efeito do diclofenaco sobre a dor e sintomas associados em pacientes com crise de migrânea. Sessenta pacientes com migrânea com aura e sessenta pacientes com migrânea sem aura foram randomizados para receber diclofenaco intramuscular, na dose de 75 mg, associado com injeção intravenosa de solução salina, 10 ml, ou para receber solução salina isoladamente. Três parâmetros de avaliação analgésica e uma escala analógica para avaliar os sintomas associados foram usados. Aferimos ainda os percentuais de recorrência e de utilização de medicação de resgate. Pacientes que receberam diclofenaco apresentaram redução na intensidade da dor estatisticamente significativa, 60 minutos após a administração, em dois dos três parâmetros utilizados (migrânea sem aura e nos três parâmetros utilizados (migrânea com aura. Não observamos diferença, comparado com o placebo, na intensidade dos sintomas associados. Houve redução da recorrência e da utilização de medicação de resgate. A despeito de ser uma opção no tratamento das migrâneas em unidades de emergência, o diclofenaco apresenta início de ação lento e nenhum efeito nos sintomas associados.The aim of this study is to assess, in a double blind fashion, the effect of diclofenac on the pain and associated symptoms in patients with acute migraine. 60 patients with migraine with aura and 60 patients with migraine without aura were assigned at random to receiving intramuscular diclofenac, 75 mg associated to intravenous physiological saline, 10 ml, or physiological saline alone. We used 3 parameters of analgesic evaluation and an analogical scale to asses associated symptoms. We also observed the recurrence and rescue medication percentiles. Patients receiving diclofenac showed a statistically significant improvement of pain 60 minutes after the administration in two of the three parameters

  11. Efeito imunossupressor da ciclosporina intra-muscular administrada em diferentes períodos pós-operatórios em um modelo de transplante penetrante de córnea em ratos Immunosuppressive effect of intramuscular cyclosporine used at different post-operative period on a penetrating keratoplasty model in the rat

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    Roberto von Hertwig

    1999-12-01

    Full Text Available Objetivo: Avaliar o efeito imunossupressor da ciclosporina intramuscular (I.M., administrada por tempo limitado em diferentes períodos do pós-operatório, no transplante penetrante de córnea em um modelo experimental em rato, por meio de avaliação clínica e anátomo-patológica do enxerto corneano. Método: Foram utilizados ratos isogênicos Fischer como doadores e Lewis como receptores, em um modelo ortotópico de transplante de córnea. A administração de ciclosporina I.M. 10 mg/kg/dia foi iniciada em diferentes períodos nos grupos estudados: no pós-operatório imediato, no 7º dia pós-operatório e no 9º dia pós-operatório. A ciclosporina quando iniciada foi administrada até o 30º dia pós-operatório. Um grupo controle não recebeu a ciclosporina I.M. Os enxertos corneanos foram avaliadas clínica e histologicamente. Resultados: Rejeição foi observada nas primeiras três semanas do pós-operatório em 100% dos casos no grupo controle (n = 5 que não recebeu a ciclosporina. Os ratos tratados com ciclosporina (n = 15 apresentaram rejeição em apenas um caso, que teve curta evolução e poucos sinais clínicos. Os estudos histológicos confirmaram as avaliações clínicas. O grupo controle apresentou infiltrado no enxerto corneal com predomínio de linfócitos sobre neutrófilos com mais neovasos, com mais fibrose e com infiltrado inflamatório mais intenso do que os grupos tratados com ciclosporina. Conclusão: Os dados obtidos indicam que a ciclosporina I.M., pode ter efeito benéfico sobre o controle da rejeição do transplante de córnea, mesmo na sua fase ativa.Purpose: Corneal graft rejection suppression after intramus-cular cyclosporine administration at different periods of time was studied on a penetrating keratoplasty rejection model in the rat. Methods: Inbred Lewis rats were used as recipients and Fischer rats were used as donors in a orthotopic rejection model of corneal transplantation. Intramuscular injection

  12. Imunodeficiência Combinada Grave – O Diagnóstico Precoce é Importante?

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    Simão, I; Valente, R; Farela Neves, J; Neves, C

    2011-01-01

    Introdução: Os doentes com Imunodeficiência Combinada Grave (SCID) não diagnosticados evoluem inexoravelmente para a morte no primeiro ano de vida. Um elevado índice de suspeição é fundamental para o diagnóstico precoce, o factor mais importante para a sobrevida destas crianças. Objectivo: Apresentam-se três casos clínicos ilustrativos da importância da precocidade diagnóstica no prognóstico final. Casos clínicos: Caso clínico 1: Lactente do sexo masculino, com antecedentes de inf...

  13. Rituals in nursing: intramuscular injections.

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    Greenway, Kathleen

    2014-12-01

    To consider to what extent intramuscular injection technique can be described to remain entrenched in ritualistic practice and how evidence-based practice should be considered and applied to the nursing practice of this essential skill. The notion of rituals within nursing and the value or futile impact they afford to this essential nursing skill will be critically reviewed. Discursive paper. Literature review from 2002-2013 to review the current position of intramuscular injection injections. Within the literature review, it became clear that there are several actions within the administration of an intramuscular injection that could be perceived as ritualistic and require consideration for contemporary nursing practice. The essential nursing skill of intramuscular injection often appears to fit into the description of a ritualised practice. By providing evidence-based care, nurses will find themselves empowered to make informed decisions based on clinical need and using their clinical judgement. For key learning, it will outline with rationale how site selection, needle selection, insertion technique and aspiration can be cited as examples of routinised or ritualistic practice and why these should be rejected in favour of an evidence-based approach. The effect on some student nurses of experiencing differing practices between what is taught at university and what is often seen in clinical practice will also be discussed. © 2014 John Wiley & Sons Ltd.

  14. El Buen Ordeño es muy Importante

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    Blackman Charles

    1947-06-01

    Full Text Available El ordeño es uno de los mayores trabajos de las fincas lecheras y es también uno de los más importantes. La forma en que se ordeña las vacas determina en gran parte la calidad de la leche e influye además sobre la cantidad de leche producida. Las vacas lecheras deben ser ordeñadas dos veces al día, a intervalos iguales.

  15. Soroprevalência da hepatite B e avaliação da resposta imunológica à vacinação contra a hepatite B por via intramuscular e intradérmica em profissionais de um laboratório de saúde pública Hepatitis B seroprevalence and evaluation of immune response to hepatitis B vaccination using intramuscular and intradermal routes in public health laboratory employees

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    Regina Célia Moreira

    2007-10-01

    Full Text Available OBJETIVOS: Determinar a prevalência dos marcadores da hepatite B (HBsAg e anti-HBs e avaliar a resposta à vacinação contra hepatite B por via intradérmica (ID em profissionais de saúde que não responderam à vacinação por via intramuscular (IM. MÉTODO: Todos os funcionários do Instituto Adolfo Lutz (IAL foram convidados a participar do estudo. Amostras de soro foram colhidas no momento da administração da primeira dose de vacina (Engerix® B e o HBsAg e o anti-HBs foram pesquisados, utilizando-se kits comerciais (Laboratórios Abbott®. Aos funcionários que não responderam à vacinação convencional (três doses por via IM foram oferecidas doses de 5µg da mesma vacina por via ID. RESULTADOS: Foram envolvidos nesse estudo 404 funcionários do IAL, dos quais dois (0,5% eram HBsAg e 42 (10,5%, anti-HBs reagentes. Dos 360 voluntários com sorologia negativa, 316 (87,8% receberam três doses de vacina (IM e, desses, 259 colheram soros para avaliação pós-vacinal. Do total, 242 (93,4% apresentaram anticorpos acima de 10 UI/L após completarem o esquema inicial. Foram administradas duas doses de reforço, porém sete funcionários permaneceram sem resposta imunológica. A vacinação intradérmica foi realizada em cinco voluntários, e todos produziram anticorpos após a utilização dessa via de administração. CONCLUSÕES: A prevalência da hepatite B não foi maior nessa população do que na população geral. A vacinação por via intradérmica pode ser uma boa alternativa na imunização de pessoas que não respondem ao esquema convencional.OBJECTIVES: To determine the prevalence of HBsAg and anti-HBs and to evaluate the response of intradermal hepatitis vaccination in healthcare workers non-responsive to previous repeated intramuscular vaccination. MATERIAL AND METHOD: All of the employees from Instituto Adolfo Lutz were invited to participate on this study. Serum samples were obtained and HBsAg and anti-HBs were detected

  16. Revisión de algunos aspectos importantes

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    J. A. Ávila

    2012-01-01

    Full Text Available El soporte nutricional adecuado y oportuno contribuye en la reducción del riesgo de infecciones, mejora la función inmune y el pronóstico del paciente; es por esto que se destaca la importancia de mantener un adecuado estado nutricional en los pacientes críticamente enfermos. Con este propósito, el presente documento resalta el valor de la nutrición parenteral y su papel en aquellos animales con desnutrición presente o prevista, siempre y cuando la vía enteral no esté disponible o sea insuficiente; esto, en razón de su metabolismo alterado, el cual predispone a un mayor catabolismo mus-cular. La correcta elaboración de un plan nutricional debe tener en cuenta aspectos de gran importancia como la evaluación integral de los hallazgos históricos, clínicos y paraclínicos, con el fin de detectar el grado o riesgo de desnutrición; por su parte, la selección del tipo de nutrición más adecuada y el tipo de solución por emplear, son variables igualmente relevantes pues varían según cada caso particular, dependiendo de la condición del paciente y el tipo de patologías asociadas. Así pues, el cálculo de los requerimientos calóricos y la manera en que estos serán suplementados, son variables que deben manejarse con cautela, con el fin de no exceder la capacidad metabólica y desencadenar complicaciones que representen mayor morbilidad y mortalidad. Por úl-timo, es importante resaltar que la nutrición parenteral debe descontinuarse tan pronto como sea posible para disminuir los problemas relacionados con la misma, como la atrofia gastrointestinal.

  17. Nicolau Syndrome after Intramuscular Benzathine Penicillin Injection

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    Morteza Noaparast

    2014-11-01

    Full Text Available A 3-year-old boy was admitted to the emergency department with right lower limb pain, edema, and livedoid discoloration that occurred immediately after intramuscular injection of benzathine penicillin. The patient was diagnosed with Nicolau syndrome, a rare complication of intramuscular injection presumed to be related to the inadvertent intravascular injection. It was first reported following intramuscular injection of bismuth salt, but it can occur as a complication of various other drugs. Fasciotomy was carried out due to the resultant compartment syndrome and medical therapy with heparin, corticosteroid, and pentoxifyllin was initiated.

  18. Unusual intramuscular lipoma of deltoid muscle.

    Science.gov (United States)

    Kapetanakis, Stylianos; Papathanasiou, Jiannis; Dermon, Antonios; Dimitrakopoulou, Alexandra; Ververidis, Athanasios; Chloropoulou, Pelagia; Kazakos, Konstantinos

    2010-01-01

    Lipomas are common soft tissue tumors usually located under the skin. Nevertheless, intramuscular lipomas of deltoid muscle are unusual tumors. We present a case of 74-year-old woman with an intramuscular like clepsydra lipoma of deltoid muscle. The lesion was a palpable soft mass at the lateral side of the humerus. The patient had no previous history of trauma. The main symptom was pain only in abduction and extension. Imaging, pathological findings and surgical excision are discussed.

  19. Cellulitis Developing After Intramuscular Metamizole Injection

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    Onur Ozturk

    2016-12-01

    Full Text Available If the suitable technique is not used in intramuscular injection applications and the injection area is not detected correctly, complications may be observed. Our patient was given intramuscular Metamizole in his house and then he had cellulitis with necrosis area. Following an antibiotic treatment, tissue defect was primarily covered with gluteal muscle skin flap. Cellulitis development after metamizole injection is not common still potential side effects should be considered before prescription.

  20. Nicolau Syndrome after Intramuscular Injection: 3 Cases

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    Seok-Kwun Kim

    2012-05-01

    Full Text Available Nicolau syndrome is a rare complication of intramuscular injection consisting of ischemic necrosis of skin, soft tissue, and muscular tissue that arises locoregionally. The characteristic pattern is pain around the injection site, developing into erythema, a livedoid dermatitis patch, and necrosis of the skin, subcutaneous fat, and muscle tissue. Three patients were injected with drugs (diclofenac sodium, ketoprofen, meperidine for pain relief. Three patients complained of pain, and a skin lesion was observed, after which necrosis developed on their buttocks. Each patient underwent debridement and coverage. The wound healed uneventfully. We report three cases of Nicolau syndrome in the buttocks following diclofenac intramuscular injection.

  1. Drosophila: um importante modelo biológico para a pesquisa e o ensino de Genética

    OpenAIRE

    Rocha, Luana Diniz Linhares e Souza; Universidade Federal de Goiás; Faria, Joana Cristina Neves de Menezes; Instituto Federal de Educação, Ciência e Tecnologia de Goiás; Cruz, Aline Helena da Silva; Universidade de São Paulo; Reis, Angela Adamski da Silva; Universidade Federal de Goiás; Santos, Rodrigo da Silva; Universidade de São Paulo

    2013-01-01

    Uma das maiores dificuldades enfrentadas pelos professores de biologia é organizar o conteúdo a ser ministrado de maneira a garantir a eficiência do processo de ensino-aprendizagem. Nesse sentido, as Drosophilas têm sido aliadas dos professores durante aulas teóricas e práticas não só de zoologia, mas também de genética e ecologia, além de serem modelos utilizados intensamente na pesquisa, o que permite aos professores uma complementação das aulas com debates de atualidades científicas utiliz...

  2. Necrotizing Soft Tissue Fasciitis after Intramuscular Injection

    Directory of Open Access Journals (Sweden)

    Angelica Abbate

    2018-01-01

    Full Text Available Necrotizing soft tissue fasciitis (NSTIs or necrotizing fasciitis is an infrequent and serious infection. Herein, we describe the clinical course of a female patient who received a diagnosis of NSTIs after gluteus intramuscular injection. We also report the results of our review of published papers from 1997 to 2017. Since now, 19 cases of NSTIs following intramuscular injections have been described. We focus on the correlation between intramuscular injection and NSTIs onset, especially in immunosuppressed patients treated with corticosteroids, suffering from chronic diseases or drug addicted. Intramuscular injections can provoke severe tissue trauma, representing local portal of infection, even if correctly administrated. Otherwise, it is important not to inject drug in subcutaneous, which is a less vascularized area and therefore more susceptible to infections. Likewise, a proper injecting technique and aspiration prior to injection seem to be valid measure to prevent intra-arterial or para-arterial drug injection with the consequent massive inflammatory reaction. Necrosis at the infection site appears to be independent of the drug, and it is a strong additional risk factor for NSTIs.

  3. Myostatin inhibits porcine intramuscular preadipocyte differentiation in vitro.

    Science.gov (United States)

    Sun, W X; Dodson, M V; Jiang, Z H; Yu, S G; Chu, W W; Chen, J

    2016-04-01

    This study assessed the effect of myostatin on adipogenesis by porcine intramuscular preadipocytes. Intramuscular preadipocytes were isolated from the longissimus dorsi muscle of newborn pigs. Myostatin inhibited intramuscular preadipocyte differentiation in a dose-dependent manner. Myostatin treatment during preadipocyte differentiation significantly (P Myostatin also significantly (P myostatin acts as an extrinsic regulatory factor in regulating intramuscular adipogenesis. Copyright © 2016 Elsevier Inc. All rights reserved.

  4. Nicolau syndrome following intramuscular benzathine penicillin

    Directory of Open Access Journals (Sweden)

    De Sousa R

    2008-01-01

    Full Text Available Nicolau syndrome (NS is a rare complication of an intramuscular injection characterized by severe pain, skin discoloration, and varying levels of tissue necrosis. The case outcomes vary from atrophic ulcers and severe pain to sepsis and limb amputation. We describe a case of a seven-year-old boy with diagnosis of NS after intramuscular benzathine penicillin injection to the ventrolateral aspect of the left thigh. Characteristic violaceous discoloration of skin and immediate injection site pain identified it as a case of NS. The case was complicated by rapid progression of compartment syndrome of the lower limb, proceeding to acute renal failure and death. Associated compartment syndrome can be postulated as a poor prognostic factor for NS.

  5. Two Intramuscular Lipoma Case Reports: Radiological Findings

    Directory of Open Access Journals (Sweden)

    Ayse Umul

    2016-09-01

    Full Text Available Lipomas are common soft tissue tumors of mesenchymal origin.They contain mature adipose tissue. They are usually located in the subcutaneous tissue. They rarely ocur within the muscle and then are called intramuscular lipomas. Ultrasonography is the first diagnostic method to be selected. However, cross-sectional imaging methods are more useful in the diagnosis. On Magnetic resonance imaging (MRI, with the help of signal characteristics and fat suppression techniques,diagnosis is easily achieved. In addition, the relationship of lesion with the adjacent anatomical structures can be assessed better with MRI. Here, will be explained two different intramuscular lipoma cases and imaging findings will be reviewed. [J Contemp Med 2016; 6(3.000: 221-225

  6. Intramuscular metastasis from malignant melanoma: MR findings

    Energy Technology Data Exchange (ETDEWEB)

    Yoshioka, Hirohi; Itai, Yuji; Niitsu, Mamoru [Dept. of Radiology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki (Japan); Fujiwara, Masachika; Watanabe, Teruo [Department of Pathology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba (Japan); Satomi, Hisae; Otsuka, Fujio [Department of Dermatology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba (Japan)

    1999-12-01

    We present a rare case of intramuscular metastasis from malignant melanoma. The lesion showed intermediate to high signal intensity on T1-weighted magnetic resonance (MR) images and mixed signal intensities containing high and low signals on T2-weighted images. The signal intensity on T1-weighted images, which is due to the paramagnetic effect of melanin, is a characteristic MR finding of this entity. (orig.)

  7. Intra-muscular hemangioma: A review

    Directory of Open Access Journals (Sweden)

    Shruti Nayak

    2014-01-01

    Full Text Available Intra-muscular hemangiomas (IMH are relatively uncommon benign vascular tumors, which account for less than 1% of all hemangiomas. IMH may be presented as a perceived sporting injury. Diagnosis of this lesion is important not only because of its rarity, but also due to dangers posed by misdiagnosis and mismanagement. They must be considered in the differential diagnosis of unexplained pain and swelling in muscles. IMH occurring in the oral cavity is reviewed below.

  8. Nicolau Syndrome after Intramuscular Injection: 3 Cases

    Directory of Open Access Journals (Sweden)

    Seok-Kwun Kim

    2012-05-01

    Full Text Available Nicolau syndrome is a rare complication of intramuscular injection consisting of ischemicnecrosis of skin, soft tissue, and muscular tissue that arises locoregionally. The characteristicpattern is pain around the injection site, developing into erythema, a livedoid dermatitispatch, and necrosis of the skin, subcutaneous fat, and muscle tissue. Three patients wereinjected with drugs (diclofenac sodium, ketoprofen, meperidine for pain relief. Three patientscomplained of pain, and a skin lesion was observed, after which necrosis developed on theirbuttocks. Each patient underwent debridement and coverage. The wound healed uneventfully.We report three cases of Nicolau syndrome in the buttocks following diclofenac intramuscularinjection.

  9. Histological properties of intramuscular connective tissues in native ...

    African Journals Online (AJOL)

    The conventional histological study revealed that except the endomysium which was similar in both muscles, the other intramuscular connective tissues' layers varied between leg and breast muscles and were affected by sex. All the connective tissue fibers were observed in all the intramuscular connective tissues of both ...

  10. Reliability and agreement of intramuscular coherence in tibialis anterior muscle

    NARCIS (Netherlands)

    Asseldonk, E.H. van; Campfens, S.F.; Verwer, S.J.; Putten, M.J.A.M. van; Stegeman, D.F.

    2014-01-01

    BACKGROUND: Neuroplasticity drives recovery of walking after a lesion of the descending tract. Intramuscular coherence analysis provides a way to quantify corticomotor drive during a functional task, like walking and changes in coherence serve as a marker for neuroplasticity. Although intramuscular

  11. Reliability and Agreement of Intramuscular Coherence in Tibialis Anterior Muscle

    NARCIS (Netherlands)

    van Asseldonk, E.H.F.; Campfens, S.F.; Verwer, S.J.F.; van Putten, M.C.; Stegeman, D.F.

    2014-01-01

    Background: Neuroplasticity drives recovery of walking after a lesion of the descending tract. Intramuscular coherence analysis provides a way to quantify corticomotor drive during a functional task, like walking and changes in coherence serve as a marker for neuroplasticity. Although intramuscular

  12. Reliability and agreement of intramuscular coherence in tibialis anterior muscle

    NARCIS (Netherlands)

    van Asseldonk, Edwin H.F.; Campfens, S.F.; Verwer, S.J.F.; van Putten, Michel Johannes Antonius Maria; Stegeman, D.F.

    2014-01-01

    Background: Neuroplasticity drives recovery of walking after a lesion of the descending tract. Intramuscular coherence analysis provides a way to quantify corticomotor drive during a functional task, like walking and changes in coherence serve as a marker for neuroplasticity. Although intramuscular

  13. Uma análise dos atributos importantes no processo de decisão de compra de notebooks utilizando análise fatorial e escalonamento multidimensional.

    Directory of Open Access Journals (Sweden)

    Valter Afonso Vieira

    2006-12-01

    Full Text Available Identificar atributos importantes no processo decisório do consumidor é uma tarefa árdua para profissionais de marketing. Diversos são os segmentos que necessitam de tais tipos de pesquisas. Com base nesse contexto, este artigo tem como objetivo identificar os atributos importantes considerados pelos consumidores na compra de notebook. Para tal fim, realizou-se uma pesquisa exploratória-qualitativa por meio da entrevista de profundidade com profissionais da área de informática e com potenciais compradores de notebook. Os resultados, após análise de conteúdo, demonstraram 42 atributos considerados para a compra. Em um segundo momento foi realizada uma etapa quantitativa tipo survey com uma amostra bola-de-neve de 131 entrevistados. Assim, após aplicação da análise fatorial exploratória, cinco dimensões foram identificadas, correspondendo aos atributos mais importantes para o processo de decisão de compra. As dimensões foram classificadas como prazer e benefício, características do aparelho, desempenho, cautela e operacional. Por fim, conclusões finais e pesquisas futuras são apresentadas e discutidas.

  14. Seguimento de um humano por um robô companheiro

    OpenAIRE

    Amorim, Diogo Samuel Bento

    2016-01-01

    Cada vez mais surgem robôs a partilhar o mesmo espaço físico que os humanos. Deste modo é importante pensar em como os robôs interagem com um humano e na partilha do mesmo espaço que eles. A forma como se movem e reagem passa a ter cada vez mais relevância e é uma componente cada vez mais presente em sistemas robóticos móveis. Aspetos relacionados com a movimentação do robô que não estão diretamente relacionados com comandos rígidos podem ter um impacto muito signi cativo na fo...

  15. Intramuscular degeneration process in Duchenne muscular dystrophy

    International Nuclear Information System (INIS)

    Hasegawa, Takeshi; Matsumra, Kiichiro; Hashimoto, Takahiro; Ikehira, Hiroo; Fukuda, Hiroshi; Tateno, Yukio.

    1992-01-01

    Intramuscular degeneration process of Duchenne dystrophy skeletal muscles was investigated by longitudinal skeletal muscle imaging with high-field-strength NMR-CT of 1.5 Tesla. Thigh muscles in 10 cases ranging in age from 4 to 19 years were examined by T 1 -weighted longitudinal images (TR=215∼505 ms, TE=19∼20 ms). The following results were obtained. Skeletal muscle degeneration was depicted as high signal intensity area reflecting its high fat contents. These high signal intensity areas had a longitudinally streaky appearance in parallel direction with myofibers. These findings were more prominent toward myotendon junction than muscle bellies. Skeletal muscle degeneration progressed rapidly between 7 to 10 years of age, and reached a plateau after that. (author)

  16. Basic principles for measurement of intramuscular pressure

    Science.gov (United States)

    Hargens, A. R.; Ballard, R. E.

    1995-01-01

    We review historical and methodological approaches to measurements of intramuscular pressure (IMP) in humans. These techniques provide valuable measures of muscle tone and activity as well as diagnostic criteria for evaluation of exertional compartment syndrome. Although the wick and catheter techniques provide accurate measurements of IMP at rest, their value for exercise studies and diagnosis of exertional compartment syndrome is limited because of low frequency response and hydrostatic (static and inertial) pressure artifacts. Presently, most information on diagnosis of exertional compartment syndromes during dynamic exercise is available using the Myopress catheter. However, future research and clinical diagnosis using IMP can be optimized by the use of a miniature transducer-tipped catheter such as the Millar Mikro-tip.

  17. Magnetic resonance imaging of intramuscular metastases

    International Nuclear Information System (INIS)

    Surov, Alexey; Spielmann, Rolf-Peter; Behrmann, Curd; Fiedler, Eckhard; Voigt, Wieland; Wienke, Andreas; Holzhausen, Hans-Juergen

    2011-01-01

    The aim of the present study was to analyse magnetic resonance findings of intramuscular metastases (IM) in a relatively large series. From January 2000 to January 2010, 28 patients (207 metastases) were retrospectively identified in the radiological database of the Martin-Luther-University. Several different scanning protocols were used depending on the localisation of IM. In 12 patients diffusion-weighted (DW) images were obtained with a multi-shot SE-EPI sequence. Apparent diffusion coefficient (ADC) maps were also calculated. Furthermore, fusion images were manually generated between the DW and half-Fourier acquisition single-shot turbo spin echo (HASTE) images. On T2-weighted images, 97% of the recognised IM were hyperintense in comparison to unaffected musculature, and 3% were mixed iso- to hyperintense. On T1-weighted images most IM (91%) were homogeneously isointense in comparison to muscle tissue, whereas 4% were hypointense, and 5% lightly hyperintense. ADC maps were calculated for 91 metastases ranging from 0.99 to 4.00 mm 2 s -1 (mean value 1.99 ± 0.66). ADC values of low ( 3.0) in 6%. Of the IM that were investigated with contrast medium, 88.5% showed marked enhancement. It was homogeneous in 88% and heterogenous in 6%. Rim enhancement with central low attenuation was seen in 6%. There was no difference in enhancement characteristics with respect to ADC values or fusion patterns. Peritumoral enhancement was identified in 2.4%. Magnetic resonance features of muscle metastases are relatively typical and consist of round or oval intramuscular masses with well-defined margins, marked enhancement, low or moderate ADC values, and moderate to high signal intensity on fusion images. (orig.)

  18. Habilidades auditivas e afasia: um estudo comparativo

    OpenAIRE

    Nascimento, Maria da Soledade Rolim do

    2012-01-01

    A compreensão da informação recebida pela modalidade auditiva é um requisito importante para a efetividade da comunicação, especialmente na linguagem expressiva. Este trabalho teve como objetivo avaliar a relação das habilidades auditivas com o processo de compreensão da linguagem em pacientes com afasia. Trata-se de um estudo descritivo, transversal, comparativo, com 32 sujeitos, distribuídos em dois grupos: Grupo com afasia (n=16) e Grupo controle (n=16). Os indivíduos foram ...

  19. Caracterização de novos isolados de Bacillus thuringiensis para o controle de importantes insetos-praga da agricultura

    Directory of Open Access Journals (Sweden)

    Emeline Boni Campanini

    2012-01-01

    Full Text Available A bactéria Bacillus thuringiensis Berliner produz um corpo de inclusão paraesporal (cristal de natureza proteica, formado durante a esporulação, que atua de forma eficiente no controle de insetos-praga de culturas economicamente importantes. Esse cristal é constituído de proteínas Cry, que são codificadas pelos genes cry; um isolado pode ser caracterizado pelo conteúdo de genes cry que apresenta. Visando caracterizar novos isolados no combate de insetos-praga pertencentes às ordens Lepidoptera e Coleoptera, 76 isolados bacterianos foram analisados molecularmente e tiveram seu potencial de controle avaliado por meio de bioensaios com larvas de Spodoptera frugiperda (J.E. Smith, Sphenophorus levis Vaurie e Tenebrio molitor Linnaeus. As análises moleculares indicaram 11 isolados (14,5% da coleção, contendo genes lepidóptero-específicos e 17 (22,37% com genes coleóptero-específicos. As análises de patogenicidade revelaram dois isolados com alto potencial de controle para lagartas de S. frugiperda, um para larvas de S. levis e seis prejudiciais ao desenvolvimento das larvas de T. molitor. Esses isolados de B. thuringiensis podem ser promissores no controle biológico das referidas pragas.

  20. O cerrado não é um bioma

    OpenAIRE

    Batalha,Marco Antônio

    2011-01-01

    É importante definirmos corretamente um termo, porque pode haver implicações práticas e imediatas. Dois conceitos importantes para serem definidos acuradamente são os de "cerrado" e de "bioma". Da maneira como vem sendo usado no Brasil, o conceito de bioma adquiriu erroneamente uma conotação florística. Na verdade, o conceito de bioma é similar ao de formação vegetal, mas leva em conta a associação da vegetação com a fauna e com os microrganismos. Assim, por um lado, o conceito de bioma é fis...

  1. Competencias más importantes para la disciplina administrativa en Colombia

    OpenAIRE

    Jaime Castrillón; Leonor Cabeza; Jahir Lombana

    2015-01-01

    A partir de los resultados encontrados del Proyecto Tuning Latin-America, que se replicó en Colombia, esta investigación identifica de las 47 competencias del proyecto, las 5 más importantes según la percepción de los académicos y de los empleadores, las cuales deben ser tenidas en cuenta para garantizar buenos resultados de los profesionales en administración. Las competencias también se han clasificado de acuerdo con los fundamentos filosóficos de Bédard en ontológicas, axiológicas, epistem...

  2. Intramuscular myxoma and fibrous dysplasia of bone - Mazabraud's syndrome

    International Nuclear Information System (INIS)

    Court-Payen, M.; Ingemann Jensen, L.; Bjerregaard, B.; Schwarz Lausten, G.; Skjoldbye, B.

    1997-01-01

    We present a case of Mazabroud's syndrome, a rare benign disease, with multiple intramuscular myxomas of the thoracic wall associated with fibrous dysplasia of bone. CT, MR imaging and ultrasonography (US) of the thorax showed 2 well circumscribed homogeneous intramuscular tumors. A US-guided needle biopsy with a large-core needle (2.0 mm) and a fine needle (0.8 mm) showed that the tumors were intramuscular myxomas with no sign of malignancy. 99m Tc bone scintigraphy showed a markedly increased uptake in the right lower skull, and multiple smaller foci. CT of the skull revealed a right-sided unilateral bone thickening of the orbit and the ethomoidal cells, and right-sided exophthalmia. This case history suggests that patients with multiple intramuscular myxomas should be preoperatively examined for osseous lesions. A postoperative follow-up should also be performed to detect other soft-tissue myxomas not as yet clinically detectable, or rare osseous complications. (orig.)

  3. An Unusual Location of Ossified Intramuscular Lipoma: A Case Report

    Directory of Open Access Journals (Sweden)

    Mehdi Ramezan Shirazi

    2011-09-01

    Full Text Available "nLipoma is the most common soft tissue tumor but the presence of osseous component within the tumor is quite rare. Some studies show that less than 1% of lipomas were ossified. We describe the histological, radiological and diagnostic features of an ossified intramuscular lipoma. To the best of the authors' knowledge, a symptomatic ossified intramuscular lipoma without any cortical erosion and hyperostosis has not been previously reported in the literature.

  4. COMPORTAMENTO DO CONSUMIDOR DE REFRIGERANTES: FONTES DE INFORMAÇÃO E ATRIBUTOS IMPORTANTES PARA A DECISÃO DE COMPRA

    Directory of Open Access Journals (Sweden)

    Juliana Maria Magalhães Christino

    2004-12-01

    Full Text Available O presente trabalho desenvolveu-se com o objetivo de conhecer o comportamento de compra dos consumidores de refrigerantes com ênfase para as fontes de informação utilizadas e os atributos considerados importantes para a sua decisão de compra. Para tanto, foi realizado levantamento do tipo survey, de natureza descritiva, baseado em corte transversal, com variáveis quantitativas, totalizando 400 entrevistas pessoais nas diferentes regiões administrativas de Belo Horizonte, Minas Gerais. Verificou-se que a maior parte dos entrevistados escolhe o refrigerante a comprar com base em experiências anteriores. Todavia, observou-se a existência de influências pessoais na escolha dos produtos. No que tange aos atributos do refrigerante, constatou-se que a sua qualidade, o sabor, a limpeza da embalagem, a disponibilidade do produto no ponto-de-venda, o preço, o prazo de validade, a praticidade da embalagem, o fato de o produto não fazer mal, nessa ordem, são os atributos considerados mais importantes pelos consumidores entrevistados em sua decisão de compra. Com base nos resultados obtidos na pesquisa e no modelo proposto por Engel, Blackwell e Miniard (2000, tornou-se possível propor um modelo que objetiva contribuir com os estudos sobre comportamento do consumidor de refrigerantes.

  5. Manejar las emociones, factor importante en el mejoramiento de la calidad de vida

    Directory of Open Access Journals (Sweden)

    Sandra Rocío Cano Murcia

    2012-07-01

    Full Text Available En este escrito se resaltarán algunos de los puntos más importantes de la obra de Daniel Goleman, reconocido psicólogo y autor de varios libros, entre ellos ‘’La Inteligencia Emocional’’, con el ánimo de encaminar actividades hacia el establecimiento de hábitos y el fortalecimiento de habilidades emocionales, que conlleven a una sana convivencia y que promueva el mejoramiento de la calidad de vida de cada individuo. Entendiendo esta como el “Bien Estar o Estar Bien” en términos de tranquilidad, paz interior y óptima forma de relacionarnos en sociedad.

  6. Modelo integral de productividad, aspectos importantes para su implementación

    Directory of Open Access Journals (Sweden)

    Jorge Eduardo Medina Fernández de Soto

    2010-08-01

    Full Text Available El Modelo Integral busca la optimización de la productividad, a partir de los objetivos estratégicos empresariales y el análisis y mejoramiento de la propuesta de valor para el cliente, identificando el nivel de operación óptimo y los recursos tangibles realmente necesarios. También identifica los procesos empresariales de creación de valor y es una guía hacia el desarrollo de la propuesta de valor. Además, analiza las inversiones necesarias para las nuevas propuestas de valor, buscando un crecimiento estratégico sostenible. El artículo explica en primer lugar los fundamentos y componentes del modelo y luego algunos aspectos importantes para su implementación.

  7. Invited review: mesenchymal progenitor cells in intramuscular connective tissue development.

    Science.gov (United States)

    Miao, Z G; Zhang, L P; Fu, X; Yang, Q Y; Zhu, M J; Dodson, M V; Du, M

    2016-01-01

    The abundance and cross-linking of intramuscular connective tissue contributes to the background toughness of meat, and is thus undesirable. Connective tissue is mainly synthesized by intramuscular fibroblasts. Myocytes, adipocytes and fibroblasts are derived from a common pool of progenitor cells during the early embryonic development. It appears that multipotent mesenchymal stem cells first diverge into either myogenic or non-myogenic lineages; non-myogenic mesenchymal progenitors then develop into the stromal-vascular fraction of skeletal muscle wherein adipocytes, fibroblasts and derived mesenchymal progenitors reside. Because non-myogenic mesenchymal progenitors mainly undergo adipogenic or fibrogenic differentiation during muscle development, strengthening progenitor proliferation enhances the potential for both intramuscular adipogenesis and fibrogenesis, leading to the elevation of both marbling and connective tissue content in the resulting meat product. Furthermore, given the bipotent developmental potential of progenitor cells, enhancing their conversion to adipogenesis reduces fibrogenesis, which likely results in the overall improvement of marbling (more intramuscular adipocytes) and tenderness (less connective tissue) of meat. Fibrogenesis is mainly regulated by the transforming growth factor (TGF) β signaling pathway and its regulatory cascade. In addition, extracellular matrix, a part of the intramuscular connective tissue, provides a niche environment for regulating myogenic differentiation of satellite cells and muscle growth. Despite rapid progress, many questions remain in the role of extracellular matrix on muscle development, and factors determining the early differentiation of myogenic, adipogenic and fibrogenic cells, which warrant further studies.

  8. Necessidades em saúde: questões importantes para o trabalho da enfermagem

    Directory of Open Access Journals (Sweden)

    Edir Nei Teixeira Mandu

    1999-03-01

    Full Text Available A construção de novos parâmetros e práticas em saúde e enfermagem, no sentido do efetivo exercício de direitos sociais, é um desafio posto na atualidade. Este trabalho é uma contribuição ao enfrentamento desse desafio. Olhando para o saber da enfermagem, reflete-se sobre um dado modo de interpretação das necessidades em saúde. A partir de uma discussão acerca das necessidades humanas e de sua relação com o trabalho em saúde, submete-se à crítica a interpretação das necessidades humanas/em saúde presente na teoria de Wanda de Aguiar Horta. Destaca-se na análise a importância da autonomia/autovalorização humana e a interpretação de necessidades a partir da consideração aos sujeitos que recebem-fazem saúde e ao contexto social.

  9. REVISÃO BIBLIOGRÁFICA DOS ESTUDOS RELATIVOS ÀS DIFERENTES REGIÕES PARA APLICAÇÃO DE INJEÇÃO INTRAMUSCULAR

    Directory of Open Access Journals (Sweden)

    Brigitta Elza Pfeiffer Castellanos

    Full Text Available Efetuou-se uma revisão bibliográfica até 1975 da utilização das regiões deltóide, dorso-glútea, ventro-glútea e face ântero-lateral da coxa para administração de injeção por via intra-muscular. Estes estudos foram agrupados de acordo com as diferentes regiões e reunidos, num quadro, as indicações mais importantes relativas à cada uma das regiões.

  10. DIAGNÓSTICO GENÉTICO PARA ENFERMEDADES NEURODEGENERATIVAS. UN IMPORTANTE DESAFÍO PARA CHILE

    Directory of Open Access Journals (Sweden)

    Dr. Marcelo Miranda C.

    2016-05-01

    Full Text Available En esta revisión se analizan las características hereditarias de las principales condiciones neurodegenerativas (demencias tipo Alzheimer y frontotemporal, enfermedad de Parkinson y otros cuadros como la enfermedad de Huntington. Se hace énfasis en la necesidad de contar con exámenes genéticos de confirmación diagnóstica en estos cuadros, lo que constituye una falencia en nuestro medio. Disponer de estos recursos diagnósticos permite una mejor aproximación al paciente, estableciendo un diagnóstico más certero, un pronóstico con más base y una asesoría genética adecuada. La implementación de una terapia efectiva para cada cuadro, estará basada en un futuro próximo en un diagnóstico más preciso de la condición del paciente y para esto los estudios genéticos son una herramienta muy importante de la que dispone el clínico, además de estudios de imágenes y de laboratorio con otros marcadores humorales.

  11. Sexualidad en el anciano: un elemento importante en su calidad de vida

    Directory of Open Access Journals (Sweden)

    Jorge Orihuela de la Cal

    2001-12-01

    Full Text Available Se aplicó un cuestionario a 93 personas mayores de 60 años procedentes de la ciudad de Matanzas y atendidas por el Médico y la Enfermera de la Familia, para abordar algunos aspectos importantes sobre la sexualidad. La actividad e interés sexual se conserva en la mayoría de los hombres, mientras que en las mujeres sobresale la indiferencia. Entre las enfermedades crónicas no transmisibles que padecen están la hipertensión arterial y la artrosis. Los medicamentos más empleados son los sedantes y los antihipertensivos.A questionnaire was applied to 93 persons over 60 from the city of Matanzas that are attended by the family phyisician and nurse to deal with some important aspects about sexuality. Most of men maintain their sexual activity and interest, whereas indifference prevails among women. Arterial hypertension and arthrosis are among the chronic non-comunicable diseases suffered by them. Sedatives and antihypertensives are the most used drugs.

  12. La Piedra Caliza El más Importante de los Fertilizantes Naturales

    Directory of Open Access Journals (Sweden)

    Albrecht Wm.

    1947-09-01

    Full Text Available El encalamiento del suelo ha sido por mucho tiempo un arte agrícola. El colocar piedra caliza sobre el terreno, que en otro tiempo se consideró como una labor rutinaria, ha venido a tenerse últimamente como una práctica a la que ahora se le asignan razones de índole científica. Son hechos científicos recientes los que basados en las relaciones existentes entre el suelo y la planta, nos han suministrado los fundamentos sobre los cuales se apoya el mayor rendimiento en las cosechas obtenido con la aplicación de piedra caliza a los suelos. La piedra caliza ha estado siempre a ociada a la producción de plantas leguminosas; las que a su turno se consideran como buen alimento para ganado joven y en crecimiento. Nosotros ahora justamente, nos estamos dando cuenta de que el suministro de calcio es como fertilizante tal como lo consideraron los viejos. El calcio es, en efecto, el más importante de los elementos nutritivos que pueden agregarse al suelo para ayudarlo en la producción de más abundantes cosechas, suministrándonos ellas a su vez una mejor nutrición.

  13. Supraspinatus Intramuscular Calcified Hematoma or Necrosis Associated with Tendon Tear

    Directory of Open Access Journals (Sweden)

    Alexandre Lädermann

    2015-01-01

    Full Text Available Introduction. Rotator cuff intramuscular calcification is a rare condition usually caused by heterotopic ossification and myositis ossificans. Case Presentation. We describe a patient with voluminous calcified mass entrapped in supraspinatus muscle associated with corresponding tendon tear. Histological examination corresponded to a calcified hematoma or necrosis. Patient was surgically managed with open excision of the calcified hematoma and rotator cuff arthroscopic repair. At 6 months, supraspinatus muscle was healed, and functional outcome was good. Discussion and Conclusion. We hypothesized that supraspinatus intramuscular calcified hematoma was responsible for mechanical stress on the tendon. This association has never been described.

  14. Zagreb regimen, an abbreviated intramuscular schedule for rabies vaccination.

    Science.gov (United States)

    Ren, Jiangping; Yao, Linong; Sun, Jimin; Gong, Zhenyu

    2015-01-01

    The Zagreb regimen, an abbreviated intramuscular schedule for rabies vaccination, was developed by I. Vodopija and colleagues of the Zagreb Institute of Public Health in Croatia in the 1980s. It was recommended by WHO as one of the intramuscular (IM) schedules for rabies vaccination in 2010. We reviewed the literature on the immunogenicity, safety, economic burden, and compliance of the Zagreb 2-1-1 regimen. Compared to Essen, another IM schedule recommended by WHO, Zagreb has higher compliance, lower medical cost, and better immunogenicity at an early stage. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  15. Competencias más importantes para la disciplina administrativa en Colombia

    Directory of Open Access Journals (Sweden)

    Jaime Castrillón

    2015-01-01

    Full Text Available A partir de los resultados encontrados del Proyecto Tuning Latin-America, que se replicó en Colombia, esta investigación identifica de las 47 competencias del proyecto, las 5 más importantes según la percepción de los académicos y de los empleadores, las cuales deben ser tenidas en cuenta para garantizar buenos resultados de los profesionales en administración. Las competencias también se han clasificado de acuerdo con los fundamentos filosóficos de Bédard en ontológicas, axiológicas, epistemológicas, praxiológicas. Este estudio usa una orientación descriptiva cuando se construye el ranking de las competencias y aplica una inferencia estadística para determinar el nivel de importancia de ellas. Los resultados muestran una percepción diferente para académicos y empleadores. Sin embargo, empleadores y académicos piensan que los administradores están orientados a los elementos epistemológicos y praxiológicos, tanto en las competencias genéricas como específicas. Se puede concluir que es necesario hacer un esfuerzo para cerrar la brecha entre los conocimientos y los aspectos prácticos frente a los conceptos éticos, morales y los principios ontológicos mediante una buena educación impartida en las instituciones de educación superior. Derechos Reservados © 2015 Universidad Nacional Autónoma de México, Facultad de Contaduría y Admi- nistración. Este es un artículo de acceso abierto distribuido bajo los términos de la Licencia Creative Commons CC BY-NC-ND 4.0.

  16. Polyostotic fibrous dysplasia associated with intramuscular myxomas: Mazabraud's syndrome

    International Nuclear Information System (INIS)

    Lassance Cabral, C.E.; Guedes, P.; Celso Cruz, L. Jr.; Smith, J.; Rezende, J.F.

    1998-01-01

    Mazabraud's syndrome, though uncommon, is reported increasingly frequently. It represents an entity readily recognisable radiologically on MR imaging. Awareness of the syndrome, particularly when the myxoma is solitary, can prevent misdiagnosis of intramuscular myxomas (especially when large) as malignant mesenchymal tumors containing myxoid tissue. We review the 34 cases previously reported in the literature and include a recent case from our center. (orig.)

  17. The clearance of liposomes administered by the intramuscular route

    International Nuclear Information System (INIS)

    Arrowsmith, M.; Mills, S.N.

    1982-01-01

    Iodine 131-labelled lecithin was used to label liposomes entrapping cortisone-21-palmitate. The lecithin was injected into the fascia latae muscles of rabbits and the percentage of the initial dose remaining at certain time intervals was calculated from gamma camera image data. Release from the intramuscular site occurs by diffusion from intact liposomes. (U.K.)

  18. Intravenous paracetamol versus intramuscular pethidine in relief of ...

    African Journals Online (AJOL)

    Background: Intramuscular pethidine is one of most common opioids used for labour analgesia. There are a number of concerns in the literature regarding the use of pethidine. The aim of this study is to compare analgesic efficacy of paracetamol with pethidine for labour pain in normal vaginal delivery. Materials and ...

  19. Sonographic Appearance of a Solitary Intramuscular Cysticercosis: A Case Report

    International Nuclear Information System (INIS)

    Moon, Ju Hee; Joo, Seung Ho; Shim, Joo Eun; Kim, Yee Jeong; Oh, Hyun Cheol; Kim, Tae Hwan

    2009-01-01

    The development of antiparasitic drugs and public health strategies has reduced the prevalence of cysticercosis in South Korea. In contrast, the disease is still endemic in Southeast Asia. The influx of immigrants from endemic areas has been on the increase. We report the sonographic and pathological findings of cysticercosis that presented as an intramuscular solitary mass in a 27-year-old Philippine woman

  20. Sciatic nerve palsy associated with intramuscular quinine injections ...

    African Journals Online (AJOL)

    Sct?ior ikfeclical O[ficcr. Department of Orthopaeclics, Mulago Hospital, Makerere University, Kampala, Uganda. Key Words: Sciatic nerve palsy, intramuscular injections, children, quinine dil~ydrochloride. The purpose of this paper is to show that, in children, gluteal injection of quinine dihydrochloride (QDH) may result in ...

  1. Intramuscular Injection of “Site Enhancement Oil”

    DEFF Research Database (Denmark)

    Petersen, Maria Louise; Colville-Ebeling, Bonnie; Jensen, Thomas Hartvig Lindkær

    2015-01-01

    The use of intramuscular injection of foreign substances for aesthetic purposes is well known. Complications are usually local to the site of injection but can be potentially lethal. Here, we present a case of "site enhancement oil" use in a 42-year-old man who died from asphyxia due to hanging. ...

  2. Sonographic Appearance of a Solitary Intramuscular Cysticercosis: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Moon, Ju Hee; Joo, Seung Ho; Shim, Joo Eun; Kim, Yee Jeong; Oh, Hyun Cheol; Kim, Tae Hwan [NHIC Ilsan Hospital, Ilsan (Korea, Republic of)

    2009-03-15

    The development of antiparasitic drugs and public health strategies has reduced the prevalence of cysticercosis in South Korea. In contrast, the disease is still endemic in Southeast Asia. The influx of immigrants from endemic areas has been on the increase. We report the sonographic and pathological findings of cysticercosis that presented as an intramuscular solitary mass in a 27-year-old Philippine woman

  3. DESENVOLVIMENTO E VALIDAÇÃO DE UMA ESCALA DE AVALIAÇÃO DE ATRIBUTOS IMPORTANTES PARA A ESCOLHA DE CURSOS DE INGLÊS

    Directory of Open Access Journals (Sweden)

    Fernanda Elisa Jesus Silva

    2007-12-01

    Full Text Available O crescimento de instituições que oferecem cursos de idiomas no Brasil tem sido notório nas últimas décadas, fazendo com que a competição nesse setor se tornasse bastante acirrada (Silva, 2005. Para que tais instituições possam sobreviver e crescer nesse mercado, é fundamental desenvolver estratégias mercadológicas eficazes para atrair estudantes. Nesse sentido, é imprescindível identificar os atributos que afetam a sua decisão de compra. Assim sendo, esse trabalho teve por objetivo desenvolver e validar uma escala de avaliação dos atributos considerados importantes pelos clientes na escolha de cursos de inglês. Para tanto, realizou-se um survey, por meio de entrevistas pessoais com 216 clientes potenciais em Belo Horizonte, Minas Gerais. Verificou-se que os atributos considerados importantes na escolha de cursos de inglês podem ser avaliados com base nos seguintes fatores: Qualidade dos serviços, Marca e tradição, Intercâmbio internacional, Rapidez no aprendizado, Localização comodidade, Professores (Qualidade técnica, Metodologia (Atividades extras, Infra-estrutura, Preço, Metodologia (Enfoque prático, Professores (Responsabilidade, Flexibilidade de horários e Endosso social. Os indicadores validados para avaliar tais dimensões são apresentados ao final desse artigo, bem como as limitações do trabalho e sugestões para pesquisas futuras.

  4. Vila amazonas: antes um espaço "acionado" hoje um passado esquecido

    Directory of Open Access Journals (Sweden)

    Jaqueline Ferreira de Lima Brito

    2011-03-01

    Full Text Available Um projeto inovador situado no município de Santana no Estado do Amapá, Vila Amazonas se destacou como um centro autônomo, dotado de uma perfeita infra-estrutura, que fugia dos padrões vividos no município. Um trabalho conciso de exemplar aplicação dos princípios modernistas, bem como do urbanismo progressista especificamente no que concerne a cidade industrial, onde a razão determinante de tal estabelecimento é a presença próxima de matéria-prima, existência de uma força natural suscetível e a comodidade dos meios de transportes. O estudo coloca em discussão aspectos importantes da preservação do patrimônio que no momento se encontra na eminência de ser destruído e esquecido.

  5. Um estudo sobre o mito cosmogônico: um paralelo com a criação da consciência e um enfoque de psicologia analítica

    OpenAIRE

    Mello, Elizabeth Christina Cotta

    1991-01-01

    Este estudo pretende fazer um demonstrativo de cinco mitos cosmogônicos, escolhidos inicialmente a partir de três critérios: pertencerem a civilizações, em certa medida, com características diversas; por serem civilizações histórica e culturalmente importantes; e por fim, por interesse de proximidade cultural, utilizou-se um mito cosmogônico brasileiro. O objetivo deste trabalho é mostrar que nesses mitos vamos encontrar mitemas que são estruturas básicas que desvelam questões importantes do ...

  6. Intramuscular capillary-type hemangioma: radiologic-pathologic correlation

    Energy Technology Data Exchange (ETDEWEB)

    Yilmaz, Sabri; Alomari, Ahmad I.; Chaudry, Gulraiz [Boston Children' s Hospital and Harvard Medical School, Vascular Anomalies Center, Boston, MA (United States); Boston Children' s Hospital and Harvard Medical School, Division of Vascular and Interventional Radiology, Boston, MA (United States); Kozakewich, Harry P. [Boston Children' s Hospital and Harvard Medical School, Vascular Anomalies Center, Boston, MA (United States); Boston Children' s Hospital and Harvard Medical School, Department of Pathology, Boston, MA (United States); Fishman, Steven J. [Boston Children' s Hospital and Harvard Medical School, Vascular Anomalies Center, Boston, MA (United States); Boston Children' s Hospital and Harvard Medical School, Department of Surgery, Boston, MA (United States); Mulliken, John B. [Boston Children' s Hospital and Harvard Medical School, Vascular Anomalies Center, Boston, MA (United States); Boston Children' s Hospital and Harvard Medical School, Department of Plastic and Oral Surgery, Boston, MA (United States)

    2014-05-15

    Infantile hemangiomas demonstrate a pattern of proliferative growth in infancy followed by a slow phase of involution. In contrast a rare type of vascular tumor, intramuscular capillary-type hemangioma, usually presents beyond the period of infancy with nonspecific symptoms and no evidence of involution. The purpose of this study was to characterize the clinical, imaging, histopathological characteristics and management of intramuscular capillary-type hemangioma. We performed a retrospective review of a 20-year period to identify children diagnosed with intramuscular capillary-type hemangioma. Patient demographics, imaging and histopathological findings were recorded. We included 18 children (10 boys, 8 girls) with histologically proven intramuscular capillary-type hemangioma - and adequate imaging. The mean age at presentation was 8.1 years (range 1 day to 19 years). Twelve lesions involved muscles of the extremities, 4 were located in the trunk and 2 were in the head and neck. MRI had been performed in all children and demonstrated a soft-tissue mass with flow voids, consistent with fast flow. The lesion was well-circumscribed in 16 children and intralesional fat was seen in 14. Doppler US demonstrated a heterogeneous lesion, predominantly isoechoic to surrounding muscle, with enlarged arterial feeders. Enlarged feeding arteries, inhomogeneous blush and lack of arteriovenous shunting were noted on angiography (n = 5). The most common histopathological findings were lobules of capillaries with plump endothelium and at least some adipose tissue. The lesions were excised in six children. Two children were lost to follow-up. In the remaining 10, follow-up MRI studies ranging from 3 months to 10 years showed that the lesion enlarged in proportion to the child (n = 7), demonstrated slow growth (n = 2) or remained stable (n = 1). There was no change in imaging characteristics on follow-up. Intramuscular capillary-type hemangioma is a rare benign vascular tumor of

  7. Comparison of intramuscular olanzapine, orally disintegrating olanzapine tablets, oral risperidone solution, and intramuscular haloperidol in the management of acute agitation in an acute care psychiatric ward in Taiwan.

    Science.gov (United States)

    Hsu, Wen-Yu; Huang, Si-Sheng; Lee, Bo-Shyan; Chiu, Nan-Ying

    2010-06-01

    The purpose of this study was to compare efficacy and safety among intramuscular olanzapine, intramuscular haloperidol, orally disintegrating olanzapine tablets, and oral risperidone solution for agitated patients with psychosis during the first 24 hours of treatment in an acute care psychiatric ward. Forty-two inpatients from an acute care psychiatric ward of a medical center in central Taiwan were enrolled. They were randomly assigned to 1 of the 4 treatment groups (10-mg intramuscular olanzapine, 10-mg olanzapine oral disintegrating tablet, 3-mg oral risperidone solution, or 7.5-mg intramuscular haloperidol). Agitation was measured by using the excited component of the Positive and Negative Syndrome Scale (PANSS-EC), the Agitation-Calmness Evaluation Scale, and the Clinical Global Impression--Severity Scale during the first 24 hours. There were significant differences in the PANSS-EC total scores for the 4 intervention groups at 15, 30, 45, 60, 75, and 90 minutes after the initiation of treatment. More significant differences were found early in the treatment. In the post hoc analysis, the patients who received intramuscular olanzapine or orally disintegrating olanzapine tablets showed significantly greater improvement in PANSS-EC scores than did patients who received intramuscular haloperidol at points 15, 30, 45, 60, 75, and 90 minutes after injection. These findings suggest that intramuscular olanzapine, orally disintegrating olanzapine tablets, and oral risperidone solution are as effective treatments as intramuscular haloperidol for patients with acute agitation. Intramuscular olanzapine and disintegrating olanzapine tablets are more effective than intramuscular haloperidol in the early phase of the intervention. There is no significant difference in effectiveness among intramuscular olanzapine, orally disintegrating olanzapine tablets, and oral risperidone solution.

  8. Intramuscular dissection of Baker's cysts: report on three cases

    International Nuclear Information System (INIS)

    Fang, Christopher S.J.; McCarthy, Catherine L.; McNally, Eugene G.

    2004-01-01

    Baker's cysts are fluid distensions of the gastrocnemius-semimembranosus bursa and are the most common cystic lesion around the knee. Typically cysts enlarge along intermuscular planes around the knee. We report three cases in which the expanding cyst did not respect these planes and dissected along an intramuscular route as confirmed by MR imaging. Such behaviour by Baker's cysts is hitherto unreported in the literature. Possible mechanisms to account for this phenomenon are discussed. (orig.)

  9. Intramuscular Lipid Metabolism in the Insulin Resistance of Smoking

    OpenAIRE

    Bergman, Bryan C.; Perreault, Leigh; Hunerdosse, Devon M.; Koehler, Mary C.; Samek, Ali M.; Eckel, Robert H.

    2009-01-01

    OBJECTIVE Smoking decreases insulin action and increases the risk of type 2 diabetes in humans. Mechanisms responsible for smoking-induced insulin resistance are unclear. We hypothesized smokers would have increased intramuscular triglyceride (IMTG) and diacylglycerol (DAG) concentration and decreased fractional synthesis rate (FSR) compared with nonsmokers. RESEARCH DESIGN AND METHODS Nonsmokers (n = 18, aged 20 ± 0.5 years, BMI 22 ± 0.4 kg/m2, body fat 20 ± 2%, 0 cigarettes per day) and smo...

  10. Botânica econômica, uma ciência importante para a região amazônica

    Directory of Open Access Journals (Sweden)

    Ghillean T Prance

    1988-01-01

    Full Text Available A botânica econômica é uma ciência atualmente muito importante na região amazônica e deve ser adaptada às necessidades regionais. Neste trabalho, são fornecidos dados sobre o banco genético da floresta amazônica, espécies e dados econômicos da floresta de extração, sistemas agroflorestais, aproveitamento de monoculturas, naturais e cultivo das várzeas. É necessário um forte programa de botânica econômica para criar sistemas de uso racionais da floresta amazônica.The important contribution to be made by the science of Economic Botany in today's Amazonia environment is emphasized. Economy Botany must be tailored to the current situation where and uneccesary destruction is taking place. Studies are needed of the gene pool os useful plants and their wild relatives that occur in the forest; of products suitable for extraction from the forest; of agroforest, systems; os natural monospecific stands of such species as Orbignya phalerata and Mauritia flexuosa; and of plants suitable for cultivation on the várzea. The need for a strong programme in Amazonian Economic Bot any is stressed.

  11. Islet grafting and imaging in a bioengineered intramuscular space.

    Science.gov (United States)

    Witkowski, Piotr; Sondermeijer, Hugo; Hardy, Mark A; Woodland, David C; Lee, Keagan; Bhagat, Govind; Witkowski, Kajetan; See, Fiona; Rana, Abbas; Maffei, Antonella; Itescu, Silviu; Harris, Paul E

    2009-11-15

    Because the hepatic portal system may not be the optimal site for islet transplantation, several extrahepatic sites have been studied. Here, we examine an intramuscular transplantation site, bioengineered to better support islet neovascularization, engraftment, and survival, and we demonstrate that at this novel site, grafted beta cell mass may be quantitated in a real-time noninvasive manner by positron emission tomography (PET) imaging. Streptozotocin-induced rats were pretreated intramuscularly with a biocompatible angiogenic scaffold received syngeneic islet transplants 2 weeks later. The recipients were monitored serially by blood glucose and glucose tolerance measurements and by PET imaging of the transplant site with [11C] dihydrotetrabenazine. Parallel histopathologic evaluation of the grafts was performed using insulin staining and evaluation of microvasularity. Reversal of hyperglycemia by islet transplantation was most successful in recipients pretreated with bioscaffolds containing angiogenic factors when compared with those who received no bioscaffolds or bioscaffolds not treated with angiogenic factors. PET imaging with [11C] dihydrotetrabenazine, insulin staining, and microvascular density patterns were consistent with islet survival, increased levels of angiogenesis, and with reversal of hyperglycemia. Induction of increased neovascularization at an intramuscular site significantly improves islet transplant engraftment and survival compared with controls. The use of a nonhepatic transplant site may avoid intrahepatic complications and permit the use of PET imaging to measure and follow transplanted beta cell mass in real time. These findings have important implications for effective islet implantation outside of the liver and offer promising possibilities for improving islet survival, monitoring, and even prevention of islet loss.

  12. Intramuscular versus Subcutaneous Administration of Iron Dextran in Suckling Piglets

    Directory of Open Access Journals (Sweden)

    M. Svoboda

    2007-01-01

    Full Text Available The aim of the study was to compare the development of red blood cell indices after subcutaneous versus intramuscular administration of iron dextran to suckling piglets during early postnatal period. The piglets in group I (n = 17 were injected subcutaneously (into groin with 200 mg Fe3+ as iron dextran on day 3 of life. In group II (n = 16, the piglets received intramuscular injection (into gluteal muscles of 200 mg Fe3+ as iron dextran on day 3 of life. In group III (n = 10, the piglets did not receive any iron till the age of 3 days. The blood was taken and analyzed (Hb, PCV, RBC, MCV, MCH, MCHC, Fe on days 3, 7, 14, 21, 28 and 35. Haematological indices of piglets in group III were characteristic for hypochromic anaemia. Anaemia in group III had a detrimental effect on the growth rate of piglets. The development of red blood cell indices and iron concentration in blood plasma in subcutaneously treated piglets did not differ significantly from that of intramuscularly-treated group. Both treatments prevented development of anaemia.

  13. APLASIA CUTIS CONGÉNITA – UM CASO CLÍNICO

    Directory of Open Access Journals (Sweden)

    Mónica Costeira

    2016-07-01

    Comentários: A aplasia cutis congénita é uma lesão que pode ser causadora de grande ansiedade parental, pelo que é importante ao Pediatra o seu reconhecimento e devido esclarecimento. Apesar de se tratar, na maioria das vezes, de um defeito benigno, é importante o conhecimento da sua relação com outras anomalias e síndromes de forma a otimizar a sua orientação precoce e adequada. Da mesma forma, é importante o aconselhamento genético, nos casos que assim o justifiquem.

  14. Intramuscular temperature changes during and after 2 different cryotherapy interventions in healthy individuals.

    Science.gov (United States)

    Rupp, Kimberly A; Herman, Daniel C; Hertel, Jay; Saliba, Susan A

    2012-08-01

    Crossover. To compare the time required to decrease intramuscular temperature 8°C below baseline temperature, and to compare intramuscular temperature 90 minutes posttreatment, between 2 cryotherapy modalities. Cryotherapy is used to treat pain from muscle injuries. Cooler intramuscular temperatures may reduce cellular metabolism and secondary hypoxic injury to attenuate acute injury response, specifically the rate of chemical mediator activity. Modalities that decrease intramuscular temperature quickly may be beneficial in the treatment of muscle injuries. Eighteen healthy subjects received 2 cryotherapy conditions, crushed-ice bag (CIB) and cold-water immersion (CWI), in a randomly allocated order, separated by 72 hours. Each condition was applied until intramuscular temperature decreased 8°C below baseline. Intramuscular temperature was monitored in the gastrocnemius, 1 cm below subcutaneous adipose tissue. The primary outcome was time to decrease intramuscular temperature 8°C below baseline. A secondary outcome was intramuscular temperature at the end of a 90-minute rewarming period. Paired t tests were used to examine outcomes. Time to reach an 8°C reduction in intramuscular temperature was not significantly different between CIB and CWI (mean difference, 2.6 minutes; 95% confidence interval: -3.10, 8.30). Intramuscular temperature remained significantly colder 90 minutes post-CWI compared to CIB (mean difference, 2.8°C; 95% confidence interval: 2.07°C, 3.52°C). There was no difference in time required to reduce intramuscular temperature 8°C 1 cm below adipose tissue using CIB and CWI. However, intramuscular temperature remained significantly colder 90 minutes following CWI. These results provide clinicians with information that may guide treatment-modality decisions.

  15. Islet grafting and imaging in a bioengineered intramuscular space†

    Science.gov (United States)

    Witkowski, Piotr; Sondermeijer, Hugo; Hardy, Mark A.; Woodland, David C.; Lee, Keagan; Bhagat, Govind; Witkowski, Kajetan; See, Fiona; Rana, Abbas; Maffei, Antonella; Itescu, Silviu; Harris, Paul E.

    2011-01-01

    Background Since the hepatic portal system may not be the optimal site for islet transplantation, several extrahepatic sites have been studied. Here we examine an intramuscular transplantation site, bioengineered to better support islet neovascularization, engraftment, and survival, and demonstrate that at this novel site, grafted beta cell mass may be quantitated in a real time non-invasive manner by PET imaging. Methods Streptozotocin induced rats were pretreated intramuscularly with a biocompatible angiogenic scaffold received syngeneic islet transplants 2 weeks later. The recipients were monitored serially by blood glucose and glucose tolerance measurements and by PET imaging of the transplant site with [11C] dihydrotetrabenazine. Parallel histopathologic evaluation of the grafts was done using insulin staining and evaluation of microvasularity. Results Reversal of hyperglycemia by islet transplantation was most successful in recipients pretreated with bioscaffolds containing angiogenic factors as compared to those who received no bioscaffolds or bioscaffolds not treated with angiogenic factors. PET imaging with [11C] dihydrotetrabenazine, insulin staining and microvascular density patterns were consistent with islet survival, increased levels of angiogenesis, and with reversal of hyperglycemia. Conclusions Induction of increased neovascularization at an intramuscular site significantly improves islet transplant engraftment and survival compared to controls. The use of a non hepatic transplant site may avoid intrahepatic complications and permit the use of PET imaging to measure and follow transplanted beta-cell mass in real time. These findings have important implications for effective islet implantation outside of the liver, and offer promising possibilities for improving islet survival, monitoring, and even prevention of islet loss. PMID:19898201

  16. Evaluation of Linear Regression Simultaneous Myoelectric Control Using Intramuscular EMG.

    Science.gov (United States)

    Smith, Lauren H; Kuiken, Todd A; Hargrove, Levi J

    2016-04-01

    The objective of this study was to evaluate the ability of linear regression models to decode patterns of muscle coactivation from intramuscular electromyogram (EMG) and provide simultaneous myoelectric control of a virtual 3-DOF wrist/hand system. Performance was compared to the simultaneous control of conventional myoelectric prosthesis methods using intramuscular EMG (parallel dual-site control)-an approach that requires users to independently modulate individual muscles in the residual limb, which can be challenging for amputees. Linear regression control was evaluated in eight able-bodied subjects during a virtual Fitts' law task and was compared to performance of eight subjects using parallel dual-site control. An offline analysis also evaluated how different types of training data affected prediction accuracy of linear regression control. The two control systems demonstrated similar overall performance; however, the linear regression method demonstrated improved performance for targets requiring use of all three DOFs, whereas parallel dual-site control demonstrated improved performance for targets that required use of only one DOF. Subjects using linear regression control could more easily activate multiple DOFs simultaneously, but often experienced unintended movements when trying to isolate individual DOFs. Offline analyses also suggested that the method used to train linear regression systems may influence controllability. Linear regression myoelectric control using intramuscular EMG provided an alternative to parallel dual-site control for 3-DOF simultaneous control at the wrist and hand. The two methods demonstrated different strengths in controllability, highlighting the tradeoff between providing simultaneous control and the ability to isolate individual DOFs when desired.

  17. Polyostotic fibrous dysplasia associated with intramuscular myxomas: Mazabraud syndrome

    International Nuclear Information System (INIS)

    Samper Wamba, Jose Daniel; Fernandez Bermudez, Maria Jose; Dominguez, Teresa Lorenzo; Pascua, Luis Ramos

    2015-01-01

    The authors report a new case of Mazabraud syndrome in a 69-year-old woman complaining of pain in her right thigh. Plain radiographs demonstrated radiological findings consistent with polyostotic fibrous dysplasia of the right femur and tibia. Magnetic resonance imaging (MRI) study showed soft tissue tumors located in the vastus intermedius muscle with typical signal features of intramuscular myxomas. Biopsy was not performed because of its benign nature. Symptomatic treatment was prescribed and all the lesions remained 1 year after the diagnosis

  18. Muscle enhancement using intramuscular injections of oil in bodybuilding

    DEFF Research Database (Denmark)

    Schäfer, Ch. N.; Hvolris, Jørgen Jesper; Karlsmark, Tonny

    2012-01-01

    BACKGROUND: Self-administered intramuscular injection of site enhancement oil (SEO) is a cosmetic and performance-enhancing procedure used to reshape muscles in the bodybuilder subculture, but its consequences and complications are only sporadically described. Methods: A systematic search...... in MEDLINE and EMBASE databases during the spring of 2009 and 2010. Internet searches were performed, and bodybuilder pharmacopoeias were consulted to describe SEO use and the clinical complications known. Results: One review and seven case reports were identified. Eight case reports describe oleomas caused...

  19. Técnica intramuscular na gluteoplastia de aumento

    OpenAIRE

    Carvalho, Francisco de Assis Montenegro Cido; Alcântara, Fernando Soares de; Martins, Elmiro Heli; Kruse, Ricardo Lapa; Nogueira, Régis Pinheiro; Raad, Nidall de Sousa

    2012-01-01

    INTRODUÇÃO: Região glútea harmoniosa é considerada elemento essencial na composição da beleza corporal e expressão maior de feminilidade, suscitando o crescente interesse de homens e mulheres na melhoria estética dessa região. O objetivo deste estudo é demonstrar uma alternativa às técnicas já publicadas acerca da gluteoplastia de aumento, baseada na colocação da prótese intramuscular, utilizando de forma simplificada os limites da dissecção, tendo como referência as estruturas anatômicas fix...

  20. HUMOR NO ESPAÇO ORGANIZACIONAL: UM ESTUDO INTERPRETATIVO EM UM CALL-CENTER

    Directory of Open Access Journals (Sweden)

    Raphaela Reis Conceição Castro Silva

    2014-12-01

    Full Text Available Humor é um elemento importante da interação humana; portanto, tem um impacto sobre grupos de trabalho. Este trabalho é produto de uma reflexão sobre o humor e tem como objetivo analisar seu surgimento em espaços organizacionais. O olhar cuidadoso durante o estudo, configurado pelas observações registradas no Diário de Campo e pelas entrevistas realizadas, possibilitou o entendimento sobre o papel do humor nos espaços organizacionais. Dessa forma, a pesquisa evidencia que o humor não se limita à diversão, mas atua também como recurso de mediação do processo de interação, facilitando a coesão do grupo e promovendo o enfrentamento do estresse.

  1. VENDED UM-JINGIR

    African Journals Online (AJOL)

    Dr. Nazik E. M. Mustafa

    2011-09-05

    Sep 5, 2011 ... 2. Khartoum State Ministry of Health, P.O. Box 303 Khartoum, Sudan ... Um-Jingir is a fermented indigenous Sudanese food product made mainly from ... street vended Um-Jingir might have negative effects on public health. Therefore ..... McLauchlin J, Little C and BC Hobbs Hobbs' food poisoning and food.

  2. Anatomía quirúrgica del músculo glúteo mayor: espacio Intramuscular de FROD

    Directory of Open Access Journals (Sweden)

    Freddy Rodríguez-García

    Full Text Available Antecedentes y Objetivos. El músculo glúteo mayor es el más voluminoso y superficial de la región glútea, con forma cuadrilátera, dos inserciones diferentes, espesor variable en sus distintas zonas, y cubierto con diferentes fascias o aponeurosis. Realizamos un detallado estudio de la anatomía descriptiva y quirúrgica de dicho músculo para comparar cuál de las técnicas actuales utilizadas para el aumento glúteo con implantes es más segura y cuál proporciona mejores resultados. Material y método. Estudiamos 10 cadáveres frescos facilitados por el Instituto de Medicina Legal Regional Norte, y 10 cadáveres formolizados del anfiteatro de la Universidad Libre Seccional Barranquilla (Colombia, durante el período comprendido entre marzo de 2009 y febrero de 2010. Resultados. Determinamos que el músculo glúteo mayor, además de sus características anatómicas detalladas en los textos de anatomía descriptiva, está constituido por gruesos fascículos musculares paralelos y adyacentes unidos por fuertes tabiques o septos fibroaponeuróticos, del plano superficial al profundo. En el desarrollo del estudio encontramos un espacio anatómico intramuscular en el glúteo mayor, no descrito antes en las publicaciones de Cirugía Plástica ni en los textos de Anatomía más conocidos. Se presenta como una zona limpia, de aproximadamente 10 cm. de diámetro, con delicada aponeurosis muscular en su piso, sin la presencia de los tabiques fibroaponeuróticos interfasciculares habituales y exenta de estructuras vasculonerviosas importantes. Conclusiones. Describimos un nuevo espacio intramuscular en el glúteo mayor, que identificamos como Espacio Intramuscular de FROD, que consideramos de enorme potencial quirúrgico para la ejecución de las técnicas de aumento glúteo.

  3. In vitro simulation of distribution processes following intramuscular injection

    Directory of Open Access Journals (Sweden)

    Probst Mareike

    2016-09-01

    Full Text Available There is an urgent need for in vitro dissolution test setups for intramuscularly applied dosage forms. Especially biorelevant methods are needed to predict the in vivo behavior of newly developed dosage forms in a realistic way. There is a lack of knowledge regarding critical in vivo parameters influencing the release and absorption behavior of an intramuscularly applied drug. In the presented work the focus was set on the simulation of blood perfusion and muscle tissue. A solid agarose gel, being incorporated in an open-pored foam, was used to mimic the gel phase of muscle tissue and implemented in a flow through cell. An aqueous solution of fluorescein sodium was injected. Compared to recently obtained in vivo results the distribution of the model substance was very slow. Furthermore an agarose gel of lower viscosity an open-pored foam and phosphate buffer saline pH 7.4 were implemented in a multi-channel-ceramic membrane serving as a holder for the muscle imitating material. Blood simulating release medium was perfused through the ceramic membrane including filling materials. Transport of the dissolved fluorescein sodium was, in case of the gel, not only determined by diffusion but also by convective transport processes. The more realistic the muscle simulating materials were constituted the less reproducible results were obtained with the designed test setups.

  4. Perfil lipídico da gordura intramuscular de cortes e marcas comerciais de carne bovina Lipid profile of intramuscular fat in meat cattle cuts of commercial brands

    Directory of Open Access Journals (Sweden)

    Angélica Pereira dos Santos Pinho

    2011-05-01

    Full Text Available O trabalho foi realizado para caracterizar a gordura intramuscular dos cortes contrafilé, picanha e costela de seis marcas comerciais (A, B, C, D, E e F de carne bovina comercializadas no município de Porto Alegre, Rio Grande do Sul. As amostras foram coletadas em uma rede de hipermercados. As marcas A e B foram associadas a animais de raças britânicas, as marcas C e D de animais de raças européias produzidos em sistema convencional e orgânico, respectivamente, e provenientes do Uruguai e as marcas E e F de animais sem raça definida e sistema de alimentação não identificado, obtidas em um frigorífico regional e em uma rede de hipermercados, respectivamente. As amostras foram desossadas, moídas, embaladas a vácuo e armazenadas em temperatura de resfriamento até o momento das análises. Em cada amostra foram realizadas a extração dos lipídios e a identificação dos ácidos graxos. O delineamento experimental foi inteiramente casualizado, com arranjo fatorial 6 × 3 e os dados analisados pelo procedimento GLM do aplicativo computacional SAS. Não houve interação significativa entre cortes e marcas para o perfil lipídico dos cortes comerciais. O percentual lipídico foi de 0,95; 3,01 e 0,97% nos cortes contrafilé, costela e picanha, respectivamente. A costela apresentou maior percentual de ácidos graxos (AG saturados e maior estimativa da D9 desaturase a partir do C16:0 e C18:0. O maior percentual de C18:2 cis-9, trans 11, ácido linoleico conjugado, CLA, n-6 e n-3 foi encontrado na picanha. A marca F apresentou maior grau de saturação e a marca D, maior valor de ácidos graxos poliinsaturados, relação poliinsaturados/saturados e trans18 e menor valor de ácidos graxos saturados. Houve interação significativa entre corte e marca para o conteúdo de CLA, sendo o maior conteúdo encontrado no contrafilé da marca F. As características da gordura intramuscular da carne bovina dependem do corte e da marca comercial

  5. Lealdade a um acordo estabelecido entre os escolares

    Directory of Open Access Journals (Sweden)

    Nelson Pedro-Silva

    Full Text Available Resumo Com o presente estudo objetivamos saber se os alunos consideravam a lealdade um valor mais importante do que a honestidade e a veracidade. O universo pesquisado foi composto de 40 estudantes matriculados no Ensino Fundamental II de uma cidade do interior paulista. Para a coleta de informações, empregamos duas historietas sobre a lealdade, que serviram de ponto de partida para a entrevista, segundo o modelo piagetiano. Os resultados apontaram os seguintes aspectos: a a lealdade, para ser concebida como valor, não depende do conteúdo, mas das consequências geradoras a outrem; b ela parece ser independente da experiência escolar; e c as meninas se inclinam a ver, mais do que os meninos, a lealdade a um acordo estabelecido como um valor, apesar de condenarem seu conteúdo e serem mais sensíveis aos seus resultados. Concluímos que, a despeito dos resultados, a lealdade deve ser concebida como um valor importante para os estudantes.

  6. Intramuscular vascular malformations of an extremity: findings on MR imaging and pathologic correlation

    International Nuclear Information System (INIS)

    Kim, E.Y.; Ahn, J.M.; Yoon, H.K.; Do, Y.S.; Kim, S.H.; Choo, S.W.; Choo, I.W.; Suh, Y.L.; Kim, S.M.; Kang, H.S.

    1999-01-01

    Objective. To analyze the findings of intramuscular vascular malformations of an extremity on MR imaging and to correlate these findings with histopathologic examination.Design and patients. The findings on MR imaging and the medical records of 14 patients with an intramuscular vascular malformation of the extremity were retrospectively studied. All patients underwent surgical excision. Diagnoses were based on the results of pathologic examination. Findings on MR imaging were noted and correlated with the histopathologic findings.Results. Intramuscular vascular malformations of an extremity showed multi-septate, honeycomb, or mixed appearance on MR imaging. Multi-septate areas correlated with dilated and communicating vascular spaces with flattened endothelium. Honeycomb areas corresponded to vascular spaces with inconspicuous small lumina and thickened vascular walls. Areas of increased signal intensity on T2-weighted images were found in all intramuscular vascular malformations. Infiltrative margins were more commonly seen in intramuscular lymphaticovenous malformations. Adherence to neurovascular structures and orientation of the lesion along the long axis of the affected muscle were more commonly seen in intramuscular venous malformations.Conclusions. Intramuscular vascular malformations showed either a multi-septate, honeycomb, or mixed appearance, reflecting the size of the vascular spaces and the thickness of the smooth muscles of the vessel walls. Prediction of the subtype of an intramuscular vascular malformation of an extremity on MR imaging seems to be difficult, although there are associated findings that may be helpful in the differential diagnosis of each subtype. (orig.)

  7. Discontinuing the Use of PRN Intramuscular Medication for Agitation in an Acute Psychiatric Hospital.

    Science.gov (United States)

    Hayes, Ariel; Russ, Mark J

    2016-03-01

    This study examined the impact of eliminating intramuscular PRN medication for agitation on patient and staff safety in an acute psychiatric inpatient setting. The current retrospective chart review investigated the use of PRN medications (oral and intramuscular) to treat acute agitation, including aggression, and related outcomes before and after a mandated change in PRN practice that required real time physician input before administration of intramuscular medications. The use of both oral and intramuscular PRN medications dramatically decreased following implementation of the mandated change in practice. In particular, the use of intramuscular PRNs for agitation decreased by about half. Despite this decrease, the assault rate in the hospital was unchanged, and the utilization of restraint and seclusion continued to decrease. It is possible to reduce the utilization of PRN medications for agitation without broadly compromising safety on acute care psychiatric inpatient units.

  8. Avaliando a comutatividade: importante requisito da qualidade para laboratórios clínicos Understanding commutability: important quality requirement for clinical laboratories

    Directory of Open Access Journals (Sweden)

    Chams Bicalho Maluf

    2011-12-01

    Full Text Available INTRODUÇÃO: Poucos laboratórios no Brasil realizam a avaliação da comutatividade dos resultados de exames, provavelmente por desconhecimento dos procedimentos para sua realização e também pela pouca importância dada a essa avaliação. OBJETIVO: Avaliar a comutatividade dos resultados de exames hematológicos realizados em três analisadores automatizados em um laboratório de um hospital público universitário, em Belo Horizonte, MG, Brasil, propondo procedimento prático, de baixa complexidade, factível de ser utilizado em laboratórios clínicos. MATERIAL E MÉTODOS: As amostras foram selecionadas visando obter valores nos níveis de decisão terapêutica. Foram processadas seis amostras por dia, durante quatro dias, em duplicata em três analisadores, totalizando 48 replicatas em cada instrumento. Foi avaliada a correlação entre os resultados de 10 dos principais parâmetros hematológicos obtidos nos instrumentos-teste e aqueles obtidos com o instrumento-referência. Foram estimados os erros sistemáticos e totais, considerando as especificações da variação biológica como limite máximo aceitável. RESULTADOS: O coeficiente de correlação (r entre os equipamentos para os parâmetros investigados foi > 0,975. Os erros sistemático (médio e total, obtidos para os parâmetros analisados, quando se comparam os equipamentos de teste com o de referência, atenderam às especificações da qualidade definidos. Discussão: A comutatividade é um importante processo da gestão da qualidade do laboratório clínico e visa garantir a comparabilidade de resultados de exames realizados por diferentes sistemas. CONCLUSÃO: Utilizando procedimento padronizado internacionalmente, prático e de baixa complexidade, demonstrou-se que os exames realizados nos equipamentos avaliados são equivalentes, podendo ser usados indistintamente no acompanhamento de pacientes.INTRODUCTION: Few Brazilian laboratories evaluate the commutability of test

  9. Intramuscular administration of alfaxalone for sedation in rabbits.

    Science.gov (United States)

    Huynh, Minh; Poumeyrol, Séverine; Pignon, Charly; Le Teuff, Gwenaël; Zilberstein, Luca

    2015-03-07

    Alfaxalone is a neuroactive steroid derivative of pregnanedione that was recently reintroduced to the market for use as an induction agent in small animal anaesthesia. The aim of this study was to determine an intramuscular alfaxalone dose for safe immobilisation. Ten healthy New Zealand white rabbits were used to evaluate a single intramuscular injection of alfaxalone. The design of the study was a three-way, complete block, cross-over trial to compare the effect of alfaxalone at three doses (4, 6 and 8 mg). The mean duration of the effect for the 4, 6 and 8 mg/kg doses was, respectively, 36.9 (95% CI (31.6 to 42.3)), 51.8 (46.4 to 57.2) and 58.4 (52.8 to 63.9) minutes. The loss of the righting reflex was achieved after 3.1 (2.5 to 3.8), 2.4 (1.7 to 3.1) and 2.3 (1.6 to 2.9) minutes, respectively. The mean duration of the effect for the 6 and 8 mg doses was significantly higher than for the 4 mg dose (with estimated differences of 14.8 95% CI (8.8 to 20.8) minutes and 21.4 (15.3 to 27.6) minutes, respectively). No significant dose effect was observed before the loss of the righting reflex (P=0.14). Ear pinching and limb withdrawal were elicited in all groups at every dose. Doses of 4 or 6 mg/kg could be recommended; higher doses do not provide clinical benefits and can be associated with anaesthetic complication. British Veterinary Association.

  10. El destino del ingreso de acuerdo a las diferentes variables sociodemográficas importantes en las finanzas personales

    Directory of Open Access Journals (Sweden)

    Martha Isabel Bojórquez Zapata

    2016-02-01

    como instrumento un cuestionario mediante el cual analiza las variables socio-demográficas: edad, género y nivel socioeconómico; y para el destino del ingreso: alimentación, habitación, vestido, educación, vehículo y ahorro. En los resultados obtenidos sobre el destino del dinero como un factor importante en el consumo, se observó que los grupos estudiados asignan una prioridad diferente a cada aspecto; la variable con mayor influencia es la edad (coincidiendo con los autores de las teorías del consumo, seguida por el nivel de ingresos relacionados a la zona geográfica de vivienda. No se encontraron diferencias en cuanto al género.

  11. Humor nas propagandas televisivas: um olhar qualitativo sobre as percepções dos consumidores

    OpenAIRE

    Silva, Hélcia Daniel da

    2010-01-01

    A propaganda cumpre um papel importante em favor da sociedade, economia e mercado das empresas. Seu valor no marketing é fundamental, considerada a principal ferramenta de exposição ao público, capaz de modificar comportamentos e atitudes, encantando e persuadindo os mesmos com apelos variados e que fazem a diferença no contexto propagandístico. Isto é, o humor é um apelo considerado irreverente e de sucesso quando bem usado nas peças publicitárias. É um recurso que pode facilitar o interesse...

  12. ESTUDO SOBRE AS REGIÕES PARA APLICAÇÃO DE INJEÇÃO POR VIA INTRAMUSCULAR

    Directory of Open Access Journals (Sweden)

    Brigitta Elza Pfeiffer Castellanos

    Full Text Available A administração de medicamentos por via intramuscular (IM é um procedimento desenvolvido pela enfermagem; a seleção das regiões a serem utilizadas deve levar em consideração as vantagens e desvantagens de cada um dos locais. Fez-se um levantamento das regiões mais indicadas ou utilizadas pelos enfermeiros-docentes e enfermeiros-hospitalares e do local que indicaram para a punção com a agulha; foi verificado se havia alguma diferenciação na escolha da região de acordo com o sexo e idade do cliente e qual era o conhecimento sobre as contra-indicações e as complicações na utilização de cada uma das regiões para aplicação de injeção IM. Dos dados levantados, concluiu-se que as regiões deltóide, dorso-glútea e face ântero-lateral da coxa são as preferencialmente utilizadas por ambos os grupos, tendo sido constatado que a sua localização nem sempre foi anatomicamente correta e para escolha da região cerca de 80% da população investigada levou em consideração a idade do cliente. Apenas algumas contraindicações e complicações mencionadas foram concordantes com as analisadas pelos autores consultados; ressalta-se que a região ventroglútea, tida como a mais segura e adequada por estes autores, foi a menos mencionada como utilizada por ambos os grupos de enfermeiros.

  13. INFLUENCE OF GENETIC POLYMORPHISM IN FABP3 AND LEPR GENES ON INTRAMUSCULAR FAT CONTENT IN PIG CARCASSES

    Directory of Open Access Journals (Sweden)

    Kristina Budimir

    2014-06-01

    Full Text Available Intensive production conditions, selection directed to increase the percentage of muscle tissue in carcasses and consumer demand have led to a reduction of intramuscular fat content in pig carcasses. Intramuscular fat is a factor affecting the flavor, juiciness and tenderness of pork meat. FABP protein family causes the differences in the content of intramuscular fat in different pig breeds. FABP3 and LEPR gene are candidate genes for intramuscular fat content and their polymorphisms explain the variability that can occur in different pig breeds. The aim of this paper is to demonstrate the influence of genes on different intramuscular fat content in pig carcasses due to pigs genotype.

  14. Intramuscular versus ultrasound-guided intratenosynovial glucocorticoid injection for tenosynovitis in patients with rheumatoid arthritis

    DEFF Research Database (Denmark)

    Ammitzbøll-Danielsen, Mads; Østergaard, Mikkel; Fana, Viktoria

    2017-01-01

    and tenosynovitis were randomised into two double-blind groups: (A) 'intramuscular group', receiving intramuscular injection of betamethasone and US-guided intratenosynovial isotonic saline injection and (B) 'intratenosynovial group' receiving saline intramuscularly and US-guided intratenosynovial betamethasone......% (2/24) versus 44% (11/25), that is, difference of ?36pp (?58pp to ?13pp), p=0.003. Most US, clinical and patient-reported scores improved more in the 'intratenosynovial group' at all follow-up visits. Conclusions In this randomised double-blind clinical trial, patients with RA and tenosynovitis...

  15. Um estudo empírico de um sistema de reconhecimento facial utilizando o classificador KNN

    Directory of Open Access Journals (Sweden)

    Fabio Abrantes Diniz

    2016-06-01

    Full Text Available Neste artigo, apresenta-se um estudo empírico de otimização das taxas de acurácias resultantes de um sistema de reconhecimento facial baseado nas técnicas Eigenfaces e K-Nearest Neighbors. Foram investigadas as seguintes variáveis: imagens com três dimensões distintas, número de características (Eigenfaces, valores de k da técnica K-Nearest Neighbors e três medidas de distância (euclidiana, Manhattan e euclidiana normalizada. Os estudos foram importantes para entender empiricamente quais parâmetros são os mais relevantes para as técnicas analisadas e que resultam em melhores taxas de acurácias de reconhecimento facial. Os resultados dos experimentos comprovaram que as imagens com dimensões 12x9 pixels produzem as melhores taxas de acurácias de reconhecimento facial, combinando com a medida de distância euclidiana normalizada e um número de Eigenfaces igual a vinte.

  16. um estudo de caso

    OpenAIRE

    Costa, Cátia Filipa Pereira da

    2011-01-01

    Dissertação apresentada à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Psicologia Jurídica As situações de abuso sexual de crianças nas quais o perpetrador pertence ao sexo feminino obtiveram ao longo dos últimos anos um acrescido reconhecimento por parte da comunidade científica, evidenciado pelo significativo incremento das investigações no âmbito desta temática consistindo na sua maioria estudos de caso. Um conjunto de particularidades encont...

  17. The IDvIP Trial: A two-centre randomised double-blind controlled trial comparing intramuscular diamorphine and intramuscular pethidine for labour analgesia

    Directory of Open Access Journals (Sweden)

    Thomas Peter

    2011-07-01

    Full Text Available Abstract Background Intramuscular pethidine is routinely used throughout the UK for labour analgesia. Studies have suggested that pethidine provides little pain relief in labour and has a number of side effects affecting mother and neonate. It can cause nausea, vomiting and dysphoria in mothers and can cause reduced fetal heart rate variability and accelerations. Neonatal effects include respiratory depression and impaired feeding. There are few large studies comparing the relative side effects and efficacy of different opioids in labour. A small trial comparing intramuscular pethidine with diamorphine, showed diamorphine to have some benefits over pethidine when used for labour analgesia but the study did not investigate the adverse effects of either opioid. Methods The Intramuscular Diamorphine versus Intramuscular Pethidine (IDvIP trial is a randomised double-blind two centre controlled trial comparing intramuscular diamorphine and pethidine regarding their analgesic efficacy in labour and their side effects in mother, fetus and neonate. Information about the trial will be provided to women in the antenatal period or in early labour. Consent and recruitment to the trial will be obtained when the mother requests opioid analgesia. The sample size requirement is 406 women with data on primary outcomes. The maternal primary outcomes are pain relief during the first 3 hours after trial analgesia and specifically pain relief after 60 minutes. The neonatal primary outcomes are need for resuscitation and Apgar Score Discussion If the trial demonstrates that diamorphine provides better analgesia with fewer side effects in mother and neonate this could lead to a change in national practice and result in diamorphine becoming the preferred intramuscular opioid for analgesia in labour. Trial Registration ISRCTN14898678 Eudra No: 2006-003250-18, REC Reference No: 06/Q1702/95, MHRA Authorisation No: 1443/0001/001-0001, NIHR UKCRN reference 6895, RfPB grant

  18. Development and evaluation of a recombinant DNA vaccine candidate expressing porcine circovirus 2 structural protein Desenvolvimento e avaliação de um candidato à vacina de DNA recombinante expressando a proteína estrutural do circovírus suíno

    Directory of Open Access Journals (Sweden)

    Abelardo Silva Júnior

    2009-01-01

    Full Text Available Porcine circovirus 2 (PCV2 is generally associated with the porcine circovirosis syndrome, which is considered an important disease of swine and has potentially serious economic impact on the swine industry worldwide. This article describes the construction of a recombinant plasmid expressing the PCV2 structural protein and the evaluation of cellular and humoral immune responses produced by this recombinant vaccine in BALB/c mice. The vaccine candidate was obtained and analyzed in vivo, in an effort to determine the ability to induce a specific immune response in mice. DNA was extracted from a Brazilian PCV2 isolate and the gene coding for Cap protein was amplified by PCR and inserted into an expression plasmid. Groups of BALB/c mice were inoculated intra-muscularly and intradermally in a 15-day interval, with 100 µg and 50 µg of the vaccine construct, respectively. Another group was inoculated intramuscularly with 100 µg of empty plasmid, corresponding to the control group. Seroconversion and cellular response in BALB/c mice were compared and used for vaccine evaluation. Seroconversion was analyzed by ELISA. After a series of 3 immunizations the spleen cells of the immunized animals were used to perform lymphocyte proliferation assays. Seroconversion to PCV2 was detected by ELISA in the animals inoculated with the vaccine construct when compared with control groups. Lymphocyte proliferation assays showed a stronger cell proliferation in the inoculated animals compared with the control group. Thus, the vaccine candidate construct demonstrated to be able to induce both humoral and cellular responses in inoculated mice.O circovírus suíno 2 (PCV2 é geralmente associado à síndrome da circovirose suína, que é considerada uma importante doença de suínos e possui um sério impacto econômico na suinocultura mundial. Este trabalho descreve a construção de um plasmídeo recombinante que expressa a proteína estrutural do PCV2 e a avalia

  19. INTRAMUSCULAR HYDATID CYST OF PARASPINAL MUSCLE: A RARE LOCATION

    Directory of Open Access Journals (Sweden)

    Bhargava Vardhana Reddy

    2015-05-01

    Full Text Available INTRODUCTION: Hydatid disease has a worldwide distribution and causes health problems in endemic countries. The parasite has a "dog - sheep" cycle with man as an intermediate accidental host. When humans ingest the eggs of the tapeworm, the embryos that emer ge penetrate the intestinal mucosa and are transported via the circulation to various organs. Most commonly they reach the liver, lungs and the other organs are rarely affected. Primary hydatid cyst of skeletal muscle is rare, occurring in 1 - 3% of all case s. (1,2 The prevalence of intramuscular hydatid disease is reported to be less than 0.5% , because muscle is an unfavourable site for infestation because of high levels of lactic acid in muscle. (3 The diagnosis is difficult because of the unusual location, low prevalence and complicated cysts may mimic solid or complex lesions. (4 The differential diagnosis in these cases must include malignant soft - tissue tumors such as myxoid liposarcoma, soft tissue abscesses and chronic hematoma. (5 Hydatid disease of h umans caused by Echinococcus granulosus has been recognized as a major public health problem. It is found in all sheep - raising countries of the world. In India, the highest prevalence is reported from Andhra Pradesh and Tamil Nadu. (6 Injudicious approach in the management of these rare presentations may be the root cause of severe anaphylactic shock and systemic dissemination. We report an unusual case of primary hydatidosis of the paraspinal muscles

  20. Development and assessment of learning objects about intramuscular medication administration

    Directory of Open Access Journals (Sweden)

    Lilian Mayumi Chinen Tamashiro

    2014-10-01

    Full Text Available OBJECTIVES: to develop and assess a learning object about intramuscular medication administration for nursing undergraduates and nurses.METHOD: a random, intentional and non-probabilistic sample was selected of nurses from a Brazilian social network of nursing and students from the Undergraduate Program at the University of São Paulo School of Nursing to serve as research subjects and assess the object.RESULTS: the participants, 8 nurses and 8 students, studied the object and answered an assessment instrument that included the following criteria: educational aspects (relevance of the theme, objectives and texts/hypertexts, interface of the environment (navigation, accessibility and screen design and didactic resources (interactivity and presentation of resources. In total, 128 significant answers were obtained, 124 (97% of which were positive, assessed as excellent and satisfactory, considered as a flexible, dynamic, objective resources that is appropriate to the nursing learning process.CONCLUSION: the educational technology shows a clear and easily understandable language and the teaching method could be applied in other themes, contributing to the education and training of nursing professionals, positively affecting nursing teaching, stimulating the knowledge, autonomous and independent learning, aligned with the new professional education requirements.

  1. A Comparison of Intramuscular Anesthetic Techniques in Chickens

    Directory of Open Access Journals (Sweden)

    Shahin Hajighahramani

    2017-02-01

    Full Text Available Background & Objective: Administration of anesthetic substances to chickens requires careful consideration for the safe delivery of the agent to the bird. The research objective was to evaluate several drug combinations for intramuscular anesthesia in chickens for physiologic, nutritional, pharmacological and other investigations. Meterial & Methods: Sixty healthy chickens were randomly assigned in six treatment groups and received Ketamine in combination with Xylazine, Midazolam or Acepromazine. Heart and respiratory rate, induction time, duration of surgical anesthesia and light anesthesia were measured. Results: Induction of anesthesia was significantly longer following Acepromazine- Ketamine and Midazolam- Ketamine compared to other groups (P<0.05. Duration of surgical anesthesia was longest with Xylazine- Midazolam- Ketamine and shortest with Midazolam-Ketamine and Acepromazine- Ketamine (P<0.05. Conclusion: In conclusion, the most effective drug combinations resulting in longer duration of surgical anesthesia, were Xylazine- Acepromazine- Ketamine and Xylazine- Midazolam- Ketamine. Other combinations did not produce appropriate surgical anesthesia, but they make slight changes in physiological data.

  2. Are nursing students safe when choosing gluteal intramuscular injection locations?

    Science.gov (United States)

    Cornwall, J

    2011-01-01

    Nurses are required to perform gluteal intramuscular (IM) injections in practice. There are dangers associated with erroneous performance of this task, particularly with dorsogluteal injections. Knowledge regarding safe injection practice is therefore vital for nursing students. Fifty-eight second year students at a New Zealand Nursing School were given schematic drawings of the posterior and lateral aspects of the gluteal region. They were asked to mark and justify the safest location for gluteal IM injections. Fifty-seven students marked the dorsal schematic and one the lateral, with 38 (66.7%) marking in the upper outer quadrant (UOQ). Twenty indicating the UOQ (52.6%) wrote 'sciatic' or 'nerve' in justifying their location. Nineteen (33.3%) marked a location outside the UOQ; nine (47.4%) of these mentioned 'sciatic' or 'nerve' as reasons for injection safety. Overall, 50% of students mentioned 'sciatic' or 'nerve' in justifying the safety of their chosen injection location. Results suggest some second year nursing students do not understand safe gluteal IM injection locations and rationale. Current teaching practices and IM injection techniques could be revisited to prepare students more effectively; this may help prevent pathologies arising from this procedure.

  3. Meat quality and intramuscular fatty acid composition of Catria Horse.

    Science.gov (United States)

    Trombetta, Maria Federica; Nocelli, Francesco; Pasquini, Marina

    2017-08-01

    In order to extend scientific knowledge on autochthonous Italian equine meat, the physical-chemical parameters of Catria Horse Longissimus thoracis (LT) muscle and its nutritional characteristics have been investigated. Ten steaks of Catria foal raised at pasture and fattened indoors for 2 months were dissected, and LT muscle was analyzed for chemical composition, total iron, drip loss, colorimetric characteristics, intramuscular fat, fatty acid profile and nutritional indexes. Steak dissection showed that LT muscle accounted for 36.78% and fat accounted for 9.19% of weight of steak. Regarding chemical composition, protein and fat content was 20.31% and 2.83%, respectively. Total iron content (1.95 mg/100 g) was lower than data reported in the literature. Color parameters showed a luminous and intense red hue muscle. The sum of unsaturated fatty acid composition (50.3%) was higher than the sum of saturated fatty acids (46.64 %). The fatty acid profile and nutritional values of Catria Horse meat could be modified adopting extensive rearing systems and grazing. The data suggests that further investigation on the composition of Catria Horse meat should be carried out to valorize this autochthonous breed, reared in sustainable livestock systems, and its meat in local short-chain systems. © 2016 Japanese Society of Animal Science.

  4. Intramuscular ketamine to facilitate pediatric central vascular access.

    Science.gov (United States)

    Denmark, T Kent; Hargrove, Jenny R; Brown, Lance

    2004-07-01

    Obtaining prompt vascular access in young children presenting to the emergency department (ED) is frequently both necessary and technically challenging. The objective of our study was to describe our experience using intramuscular (IM) ketamine to facilitate the placement of central venous catheters in children presenting to our ED needing vascular access in a timely fashion. We performed a retrospective medical record review of all pediatric patients central venous catheter facilitated by the use of IM ketamine. Eleven children met our inclusion criteria. Most of the children were young and medically complicated. The children ranged in age from 6 months to 8 years. The only complication identified was vomiting experienced by an 8-year-old boy. Emergency physicians successfully obtained central venous access in all subjects in the case series. The use of IM ketamine to facilitate the placement of central venous catheters in children who do not have peripheral venous access appears to be helpful. Emergency physicians may find it useful to be familiar with this use of IM ketamine.

  5. Effect of intramuscular clebopride on postoperative nausea and vomiting.

    Science.gov (United States)

    Duarte, D F; Linhares, S; Gesser, N; Pederneiras, S G

    1985-01-01

    The antiemetic effect of clebopride, a new derivative of the orthopramide group, was compared with that of placebo in 298 women undergoing elective surgery. A group of 150 patients received premedication of 1 mg/kg of meperidine, administered intramuscularly (IM), and a group of 148 patients received premedication of 10 mg of diazepam IM. All patients received 0.5 mg of atropine IM. Anesthesia was induced with thiopental and maintained with halogenated N2O/O2. In a double-blind procedure, clebopride (2 mg) or placebo was injected IM at the end of anesthesia and whenever a patient had a second episode of vomiting. Clebopride appeared to be better than placebo in the prevention of nausea (P less than or equal to 0.05) and vomiting (P less than or equal to 0.001) during the 12-hour observation period. The frequency of side effects was virtually the same in patients given clebopride and patients given placebo.

  6. Intramuscular Olanzapine – a UK case series of early cases

    Directory of Open Access Journals (Sweden)

    Taylor Mark

    2007-04-01

    Full Text Available Abstract Background Clinical trials assessing efficacy and safety of Intramuscular (IM Olanzapine in acute schizophrenia and acute mania have previously been undertaken in studies required for drug registration in patients who were required to give informed consent. These patients may have less severe forms of psychosis than patients treated in routine practice. Data derived from naturalistic practice following the launch of IM olanzapine may be helpful for clinicians in assessing efficacy and safety of IM olanzapine. The PANSS-EC scale used in the clinical studies may represent a tool that could be used in routine clinical practice. Case presentation We report on an early unselected case series of 7 patients who received IM olanzapine in routine clinical practice settings in the UK. In this case series, olanzapine IM was generally effective, and no adverse events were reported. Adjunctive benzodiazepines were given concomitantly in 1 of the 7 subjects. This is relevant as concomitant benzodiazepines are not recommended for a minimum of 1 hour post IM olanzapine administration. PANSS-EC data was collected in 2 of the 7 subjects. Conclusion Although patients had greater severity of psychosis than clinical trial patients there were no unexpected findings. In addition the PANSS-EC scale is a scale that may be useful in assessing the efficacy of IM antipsychotics in routine clinical practice.

  7. BIOAVAILABILITY AND PHARMACOKINETICS OF NORFLOXACIN AFTER INTRAMUSCULAR ADMINISTRATION IN GOATS

    Directory of Open Access Journals (Sweden)

    WAJEEHA, F. H. KHAN AND I. JAVED

    2006-01-01

    Full Text Available Bioavailability and pharmacokinetics of two commercially available preparations of norfloxacin i.e. A (imported and B (locally prepared were determined in six healthy female goats after single intramuscular administration @ 5 mg/kg b.wt following crossover study design. The blood samples collected at 0.25, 0.5, 0.75, 1, 2, 3, 4, 6, 8 and 12 hours postmedication were also analysed for drug concentration by microbiological assay. Results revealed that preparation A showed higher (p<0.05 plasma drug levels than the preparation B at 1, 3, 6 and 8 hours after medication. Among bioavailability parameters AUC (g.h/ml and relative bioavailability (F% were higher for preparation A than the preparation B, while other parameters did not differ between the two preparations. Similarly, various pharmacokinetic parameters did not show any statistical difference between preparation A and B. The study revealed comparable elimination kinetics but different bioavailability of two commercial preparations of norfloxacin. It is concluded from the study that for optimal dosage regimen of drugs, the bioequivalence studies and kinetic behavior of the drugs are of paramount importance.

  8. Alternative method for intramuscular fat analysis using common laboratory equipment.

    Science.gov (United States)

    Segura, J; Calvo, L; Óvilo, C; González-Bulnes, A; Olivares, A; Cambero, M I; López-Bote, C J

    2015-05-01

    A procedure to quantify intramuscular fat was developed using common inexpensive laboratory equipment. Three homogenization methods of lyophilized muscle samples (Ball-mill, Grinder and Mortar) and two extraction methods (Ball-mill or Vortex) were used in turkey meat and pork. Two-hundred mg of lyophilized and homogenized samples were accurately weighed and mixed with 1.5 mL of dichloromethane-methanol (8:2) and shaken either in a Mixer Mill (MM400, Retsch Technology) or in a Vortex. The final mixture was separated by centrifugation. Solvent was evaporated under a nitrogen stream and lipid content was gravimetrically determined. Besides, it was checked that the fatty acid profile was not altered by the protocol used. Moreover, the analysis of 4 replicas from the same sample showed different variation coefficients (16-29%) for the new procedures proposed over a wide range of IMF content. The combination of Grinder and Vortex methodologies can be proposed as a simple and inexpensive alternative to previous ones. Copyright © 2015. Published by Elsevier Ltd.

  9. Study of Serum Drug Levels in Calves Following Intramuscular Administration of Three Tetracycline Drug Preparations

    OpenAIRE

    Black, W. D.; Claxton, J.; Robinson, G. A.

    1982-01-01

    Three antibiotic formulations, oxytetracycline (A) in propylene glycol and oxytetracycline (B) in polyvinyl pyrrolidine and pyrrolidino-methyltetracycline in an oil suspension were given to calves by the intramuscular route. Only oxytetracycline (A) appeared to cause much pain after injection.

  10. Decrease in intramuscular lipid droplets and translocation of HSL in response to muscle contraction and epinephrine

    DEFF Research Database (Denmark)

    Prats, Clara; Donsmark, Morten; Qvortrup, Klaus

    2006-01-01

    A better understanding of skeletal muscle lipid metabolism is needed to identify the molecular mechanisms relating intramuscular triglyceride (IMTG) to muscle metabolism and insulin sensitivity. An increasing number of proteins have been reported to be associated with intracellular triglyceride (TG...

  11. Pharmacokinetic Studies of Intramuscular Midazolam in Guinea Pigs Challenged With Soman

    National Research Council Canada - National Science Library

    Capacio, Benedict R; Byers, C. E; Merk, K. A; Smith, J. R; McDonough, J. H

    2004-01-01

    ...) activity following intramuscular (im) injection to soman-exposed guinea pigs (Crl:(HA)BR). Prior to experiments, the animals were surgically implanted with EEG leads to monitor seizure activity...

  12. The effect on serum enzymes of intramuscular injections of digoxin, bumetanide, pentazocine and isotonic sodium chloride

    DEFF Research Database (Denmark)

    Andersen, Klaus Ejner; Damsgaard, T

    1976-01-01

    Intramuscular injections of digoxin, bumetanide, pentazocine or isotonic sodium chloride have been given to 39 patients. We followed the serum concentrations of creatine kinase (CK), aspartate aminotransferase (ASAT), lactate dehydrogenase (LDH) and LDH isoenzymes for 4 days. Ten patients receiving...

  13. Neck and Occipital Pain Caused by Deep Cervical Intramuscular Lipoma: A Surgical Case.

    Science.gov (United States)

    Kogure, Kazunari; Yamazaki, Michio; Tamaki, Tomonori; Node, Yoji; Morita, Akio

    2017-01-01

    A lipoma is a slow-growing, benign tumor and is usually asymptomatic; hence, surgical intervention can often be avoided in patients with these tumors in the cervical and cranial area. Lipomas arise most commonly in the subcutaneous fat, but occasionally in muscle tissue. Intramuscular lipomas in the cervico-cranial area have rarely been reported. We describe here a patient with a large intramuscular lipoma in the deep cervical tissue. The patient experienced troublesome pain in the neck and occipital area, and surgical treatment was therefore suggested. Particularly in the cervical area, intramuscular lipomas sometimes invade the surrounding muscles and tissue layers and develop into an irregular mass, despite being benign. In addition, the cervical area has one of the most complex muscle structures. Nevertheless, surgical management of intramuscular lipoma in the cervical and cranial area is sometimes indicated, for example, in patients with clinical symptoms or masses with a tendency to grow large.

  14. Efficacy and Tolerability of Intramuscular Dexketoprofen in Postoperative Pain Management following Hernia Repair Surgery

    OpenAIRE

    Jamdade, P. T.; Porwal, A.; Shinde, J. V.; Erram, S. S.; Kamat, V. V.; Karmarkar, P. S.; Bhagtani, K.; Dhorepatil, S.; Irpatgire, R.; Bhagat, H.; Kolte, S. S.; Shirure, P. A.

    2011-01-01

    Objective. To evaluate the safety and efficacy of intramuscular dexketoprofen for postoperative pain in patients undergoing hernia surgery. Methodology. Total 202 patients received single intramuscular injection of dexketoprofen 50 mg or diclofenac 50 mg postoperatively. The pain intensity (PI) was self-evaluated by patients on VAS at baseline 1, 2, 4, 6, and 8 hours. The efficacy parameters were number of responders, difference in PI (PID) at 8 hours, sum of analogue of pain intensity differ...

  15. La adaptación de los alumnos inmigrantes: factores importantes para la educación

    Directory of Open Access Journals (Sweden)

    Jacqueline Graff Munaro

    2014-04-01

    Full Text Available http://dx.doi.org/10.5007/2175-795X.2014v32n1p237 Este estudio analiza la integración de los alumnos inmigrantes, en España, así como las actitudes hacia la inmigración de los alumnos españoles, en relación con variables psicosociales. El objetivo principal fue describir el proceso adaptativo e identificar variables que puedan servir para la acción educativa. El marco teórico de la aculturación y la identidad étnica es de Berry. Se realizó un estudio descriptivo y correlacional con una metodología cuantitativa y cualitativa. Los participantes eran adolescentes de 12 Institutos de la provincia de Salamanca repartidos en dos muestras: 516 autóctonos y 73 inmigrantes procedentes de América Latina, Europa, África del Norte y Central, y de Oriente (Total: 589. Se realizaron entrevistas (inmigrantes y cuestionarios para ambas muestras. Se utilizó la comparación de medias para analizar las muestras de españoles e inmigrantes por separado y después conjuntamente con las variables comunes. Se hizo un análisis de contenido de las entrevistas para conocer la apreciación del nuevo país y sus expectativas de futuro. Los resultados han demostrado que la integración es mayoritaria, pese a la discriminación. Las actitudes de los españoles hacia la inmigración fueron favorables. Estos factores están relacionados con variables psicosociales importantes para la actuación educativa: la empatía, el clima de clase, la importancia percibida de contacto y la autoestima.

  16. ¿Qué es la CIE y por qué es importante en la psicología?

    Directory of Open Access Journals (Sweden)

    Geoffrey M. Reed

    2012-01-01

    Full Text Available La Clasificación Internacional de las Enfermedades (CIE de la Organización Mundial de Salud (OMS es muy poco conocida en el ámbito de la psicología en España, y existe la falsa percepción de que su importancia es escasa en el campo de la salud mental. El propósito de este artículo es familiarizar a los psicólogos y otros profesionales en salud mental con el sistema de clasificación CIE, algo especialmente relevante al encontrarse actualmente en proceso de revisión. La OMS está haciendo un gran esfuerzo para crear una clasificación de trastornos mentales global, multicultural y multidisciplinar, centrándose en mejorar su utilidad clínica. Además, en la actual revisión de la CIE, la OMS ha adoptado el español como segunda lengua de trabajo, lo que da una gran oportunidad a los profesionales de la salud mental de España y otros países hispanohablantes de implicarse activamente en el desarrollo de la próxima versión de la clasificación. Es importante que los psicólogos de países hispanohablantes conozcan la CIE y entiendan los grandes beneficios que pueden aportarles su conocimiento y utilización para integrarse plenamente como profesión sanitaria oficial, así como para equipararse en la práctica de la psicología al resto de Europa y de todo el mundo en términos de diagnóstico y clasificación de los trastornos mentales.

  17. Serial correlation between the ultrasonographic and pathologic findings of intramuscular hemorrhaging in an experimental rabbit

    International Nuclear Information System (INIS)

    Ko, Kyung Ran; Ryu, Kyung Nam; Park, Ji Seon; Jin, Wook; Sung, Dong Wook; Park, Yong Koo

    2008-01-01

    To evaluate the serial ultrasonographic findings of experimental intramuscular hemorrhaging to determine if there is a correlation with the pathologic findings. An ultrasonography (US) was performed before and immediately after an intramuscular blood injection in nine rabbits. In addition, follow-up US images were obtained at 1, 4, 7, 10, 14, 21, and 28 days after the intramuscular blood injections in seven of the rabbits. The pathologic specimens, compared to the US findings on each date, and consisted of samples of left thigh muscle. A US, performed immediately after a blood injection, showed two patterns; 6 cases of hyperechoic muscle thickening and 3 cases of hyperechoic muscle thickening with extravasation between the epimysium and muscle bundle or within muscle bundle. A follow-up US showed a marked decrease in intramuscular hemorrhaging and microcalcifications, which appeared on the 4th, 7th and 10th day after the blood injection. The pathologic findings revealed several short echogenic lines in the muscular bundles which were hemosiderin. Moreover, a 28 day follow-up US revealed that the normal findings are correlated with the normal gross pathologic findings. The US findings of the intramuscular hemorrhaging, for each of the follow-up dates, in comparison to the pathologic findings, revealed a high correlation with the pathologic specimens. Consequently, a US transducer with high resolution can be considered as a helpful technique in the diagnosing and evaluating the follow-up treatment of intramuscular hemorrhaging

  18. Comparative Pharmacokinetics of Cefquinome (Cobactan 2.5% following Repeated Intramuscular Administrations in Sheep and Goats

    Directory of Open Access Journals (Sweden)

    Mohamed El-Hewaity

    2014-01-01

    Full Text Available The comparative pharmacokinetic profile of cefquinome was studied in sheep and goats following repeated intramuscular (IM administrations of 2 mg/kg body weight. Cefquinome concentrations in serum were determined by microbiological assay technique using Micrococcus luteus (ATCC 9341 as test organism. Following intramuscular injection of cefquinome in sheep and goats, the disposition curves were best described by two-compartment open model in both sheep and goats. The pharmacokinetics of cefquinome did not differ significantly between sheep and goats; similar intramuscular dose rate of cefquinome should therefore be applicable to both species. On comparing the data of serum levels of repeated intramuscular injections with first intramuscular injection, it was revealed that repeated intramuscular injections of cefquinome have cumulative effect in both species sheep and goats. The in vitro serum protein-binding tendency was 15.65% in sheep and 14.42% in goats. The serum concentrations of cefquinome along 24 h after injection in this study were exceeding the MICs of different susceptible microorganisms responsible for serious disease problems. These findings indicate successful use of cefquinome in sheep and goats.

  19. Serial correlation between the ultrasonographic and pathologic findings of intramuscular hemorrhaging in an experimental rabbit

    Energy Technology Data Exchange (ETDEWEB)

    Ko, Kyung Ran [National Cancer Center, Seoul (Korea, Republic of); Ryu, Kyung Nam; Park, Ji Seon; Jin, Wook; Sung, Dong Wook; Park, Yong Koo [KyungHee University Medical Center, Seoul (Korea, Republic of)

    2008-05-15

    To evaluate the serial ultrasonographic findings of experimental intramuscular hemorrhaging to determine if there is a correlation with the pathologic findings. An ultrasonography (US) was performed before and immediately after an intramuscular blood injection in nine rabbits. In addition, follow-up US images were obtained at 1, 4, 7, 10, 14, 21, and 28 days after the intramuscular blood injections in seven of the rabbits. The pathologic specimens, compared to the US findings on each date, and consisted of samples of left thigh muscle. A US, performed immediately after a blood injection, showed two patterns; 6 cases of hyperechoic muscle thickening and 3 cases of hyperechoic muscle thickening with extravasation between the epimysium and muscle bundle or within muscle bundle. A follow-up US showed a marked decrease in intramuscular hemorrhaging and microcalcifications, which appeared on the 4th, 7th and 10th day after the blood injection. The pathologic findings revealed several short echogenic lines in the muscular bundles which were hemosiderin. Moreover, a 28 day follow-up US revealed that the normal findings are correlated with the normal gross pathologic findings. The US findings of the intramuscular hemorrhaging, for each of the follow-up dates, in comparison to the pathologic findings, revealed a high correlation with the pathologic specimens. Consequently, a US transducer with high resolution can be considered as a helpful technique in the diagnosing and evaluating the follow-up treatment of intramuscular hemorrhaging.

  20. UM FINAL DE SEMANA NO ZOOLÓGICO: UM PASSEIO EDUCATIVO?

    Directory of Open Access Journals (Sweden)

    Silvania Sousa do Nascimento

    Full Text Available Os museus abertos, como parques e zoológicos, exercem um papel importante na divulgação e na popularização das ciências. Eles, geralmente, propõem atividades dirigidas ao grande público heterogêneo constituído de uma parcela considerável de grupos familiares. As atividades educativas oferecidas nesses espaços induzem diferentes níveis de interatividade entre os visitantes e os animais. Nosso artigo resume a observação de quatro grupos familiares no borboletário da Fundação Zoo-Botânica de Belo Horizonte, resultando em dados que foram avaliados qualitativamente. O resultado indica três níveis de interatividade entre os elementos de exposição desse espaço e os integrantes do grupo.

  1. Xantelasma: relato de um caso Eyelid xanthelasma: a case report

    Directory of Open Access Journals (Sweden)

    André Henrique Miranda

    2001-04-01

    Full Text Available Os autores relatam um caso raro em paciente do sexo masculino, de 71 anos de idade, com história de surgimento de "carocinho" na pálpebra superior direita há nove anos, que teve aumento importanteum ano. A tomografia computadorizada evidenciou espessamento da musculatura do reto lateral e de partes moles adjacentes. O diagnóstico pela biópsia foi de xantelasma.The authors report a rare case of a 71-year-old male patient with a 9-year history of appearance of a "little node" in the right superior eyelid, which increased significantly in size in the last year. Computed tomography showed thickening of the lateral rectus muscle and adjacent soft tissues. The diagnosis after biopsy was xanthelasma.

  2. Effect of intramuscular cholecalciferol megadose in children with nutritional rickets.

    Science.gov (United States)

    Bothra, Meenakshi; Gupta, Nandita; Jain, Vandana

    2016-06-01

    The treatment practices for vitamin D deficiency rickets are highly variable. Though a single intramuscular (IM) megadose of vitamin D is economical, and ensures good compliance, it poses the risk of hypervitaminosis D. This observational study was conducted to assess the duration of effect and safety of single IM megadose of cholecalciferol in the treatment of vitamin D deficiency rickets. Children younger than 14 years with rickets were enrolled. Baseline investigations included radiograph of wrists and estimation of serum calcium, phosphate, alkaline phosphatase (ALP), 25(OH) vitamin D and parathormone (PTH) levels. All children received a single IM megadose of vitamin D3. Biochemical parameters were re-evaluated at 1.5, 3 and 6 months after the megadose and the values were compared to the baseline. We enrolled 21 children, out of which nine remained under active follow-up till 6 months. Radiological evidence of rickets was present in all 21 children, 14 had hypocalcemia at the time of presentation. After IM cholecalciferol megadose, median 25 hydroxy vitamin D [25(OH)D] level remained significantly more than the baseline till 6 months after the megadose. At 1.5 months after the vitamin D megadose, three (30%) of the children were found to develop toxic levels of vitamin D (>150 ng/mL), although none had hypercalcemia or any clinical manifestation of vitamin D toxicity. At 3 months and 6 months after the megadose, 25(OH)D levels remained in the sufficient range (20-100 ng/mL) in seven out of the eight children who came for follow-up. A single IM megadose of vitamin D may be effective in significantly increasing the 25(OH)D levels for at least 6 months in children with rickets, but elevation of 25(OH)D to toxic range raises concern regarding its safety.

  3. Um sistema multiagente de apoio à aprendizagem baseada em problema

    Directory of Open Access Journals (Sweden)

    Laysa Mabel Oliveira Fontes

    2011-12-01

    Full Text Available A aprendizagem baseada em problema (Problem-Based Learning - PBL é uma teoria de aprendizagem que enfatiza a colaboração e o trabalho em grupo para resolução de um problema. No entanto, um problema que ocorre com freqüência no processo de aplicação da PBL é a presença de conversações fora do contexto, que é uma situação onde os estudantes perdem o foco das discussões do problema e passam a discutir outros assuntos. Outro aspecto importante é com relação ao processo de formação de grupos na PBL. Pode ser difícil para o facilitador alocar estudantes aos grupos a distância, uma vez que a ausência de um contato presencial dificulta o conhecimento de certas características importantes do perfil dos estudantes envolvidos no processo. Outro aspecto a ser considerado é a ausência de padronização dos conceitos relacionados à PBL, pois isto dificulta a compreensão comum e compartilhada sobre este domínio. Desta forma, este trabalho apresenta um sistema multiagente de apoio à PBL, com o objetivo de detectar e corrigir problemas inerentes à implantação desta teoria de aprendizagem. Para solucionar o problema de padronização dos conceitos relacionados à PBL, é proposta uma ontologia que preenche requisitos de abstração e significação dos conceitos relacionados ao domínio.

  4. OS CAMINHOS DO DIREITO: OBSTÁCULOS, FERRAMENTAS E PROCEDIMENTOS IMPORTANTES PARA SE GARANTIR A EFETIVIDADE DA LEI

    Directory of Open Access Journals (Sweden)

    DÉBORA SUELEN GOMES DE SOUZA

    2012-06-01

    Full Text Available Este artigo de revisão discute o papel do Tribunal de Justiça na Bahia a fim de promover um direito constitucionalmente previsto e teoricamente garantido, o acesso à justiça. A princípio, a abordagem se faz por meio da teoria sociológica sobre o campo jurídico. Tomamos o texto literário Diante da Lei, de Franz Kafka, como fundamento para discutir a teoria de Pierre Bordieu sobre o poder simbólico e os tipos de capitais presentes no campo jurídico. A revisão bibliográfica sobre o acesso a justiça reflete sobre as exigências e as restrições que a população, especificamente a mais pobre, enfrenta para buscar a efetividade do direito. Apesar de o acesso ser, teoricamente, direito de todos, de forma a obedecer à isonomia Constitucional, o que acontece é uma seletividade decorrente daquilo que se exige de forma direta ou indireta para adentrar ao campo jurídico. Ou seja, os critérios formais e os laços estreitos da justiça com as classes mais favorecidas implica numa refinagem a respeito de quem tem poder ou não para acessar este campo. Destacam-se as peculiaridades das normas constitucionais que deveriam ser direcionadas à sociedade como um todo, através de análise das funções dos magistrados que possuem a responsabilidade para exercer, efetivar e promover essas normas, além de analisarmos criticamente a respeito das instituições que auxiliam na efetivação desses direitos. Aborda-se assim, as condições que não condizem com os parâmetros constitucionais estabelecidos pelo Estado Democrático de Direito e pelo principio da isonomia que estabelece igualdade de direito para todos os indivíduos.Palavras-chave: poder simbólico; acesso a justiça; campo jurídico; democracia ABSTRACTThis review article discusses the role of the Court in Bahia to promote a right constitutionally theoretically predicted and guaranteed access to justice. In principle, the approach is done through the sociological theory about the legal

  5. Intramuscular aripiprazole in the acute management of psychomotor agitation.

    Science.gov (United States)

    De Filippis, Sergio; Cuomo, Ilaria; Lionetto, Luana; Janiri, Delfina; Simmaco, Maurizio; Caloro, Matteo; De Persis, Simone; Piazzi, Gioia; Simonetti, Alessio; Telesforo, C Ludovica; Sciarretta, Antonio; Caccia, Federica; Gentile, Giovanna; Kotzalidis, Georgios D; Girardi, Paolo

    2013-06-01

    To assess acute efficacy and safety of 9.75 mg of intramuscular (IM) injections of the atypical antipsychiatric aripiprazole in patients with schizophrenia or bipolar disorder and acute agitation. Open-label trial of IM injections of aripiprazole and 24-hour monitoring of clinical response in patients with major psychoses and acute agitation. Partial analysis of blood levels of the administered drug to correlate with clinical response. Acute psychiatric care wards in a single university hospital. A total of 201 acutely agitated patients (79 with schizophrenia and 122 with bipolar disorder I). Aripiprazole 9.75 mg IM injection. We evaluated clinical response using the Excitatory Component of the Positive and Negative Syndrome Scale (PANSS-EC), the Agitation/Calmness Evaluation Scale (ACES), and the Clinical Global Impressions scale (CGI). Assessments were conducted 30, 60, 90, and 120 minutes and 24 hours after the first injection for PANSS-EC and ACES, and 2, 4, 6, and 24 hours for CGI. Response was at least a 40% decrease in PANSS-EC scores. We measured serum aripiprazole and dehydroaripiprazole levels in a subsample. IM aripiprazole significantly improved clinical measures. PANSS-EC improved progressively, starting after 30 minutes. ACES improved after 90 minutes and continued thereafter. Effects were sustained, with steadily decreasing CGI scores, until the 24th hour. Response rate was 83.6% after 2 hours, but with repeat injections, it rose to over 90% with no differences among diagnostic groups. Although there were gender differences in the response to individual PANSS-EC items, the responses were similar overall. Neither clinical monitoring nor patient reporting revealed any side effects. No therapeutic window was identified, and levels did not correlate with any clinical measure. Aripiprazole was effective and safe in reducing acute agitation in patients with bipolar disorder or schizophrenia. Our results compare favorably to double-blind trials, probably

  6. Intramuscular Heating Characteristics of Multihour Low-Intensity Therapeutic Ultrasound.

    Science.gov (United States)

    Rigby, Justin H; Taggart, Rebecca M; Stratton, Kelly L; Lewis, George K; Draper, David O

    2015-11-01

    The heating characteristics of a stationary device delivering sustained acoustic medicine with low-intensity therapeutic ultrasound (LITUS) are unknown. To measure intramuscular (IM) heating produced by a LITUS device developed for long-duration treatment of musculoskeletal injuries. Controlled laboratory study. University research laboratory. A total of 26 healthy volunteers (16 men, 10 women; age = 23.0 ± 2.1 years, height = 1.74 ± 0.09 m, mass = 73.48 ± 14.65 kg). Participants were assigned randomly to receive active (n = 20) or placebo (n = 6) LITUS at a frequency of 3 MHz and an energy intensity of 0.132 W/cm(2) continuously for 3 hours with a single transducer or dual transducers on the triceps surae muscle. We measured IM temperature using thermocouples inserted at 1.5- and 3-cm depths into muscle. Temperatures were recorded throughout treatment and 30 minutes posttreatment. We used 2-sample t tests to determine the heating curve of the LITUS treatment and differences in final temperatures between depth and number of transducers. A mild IM temperature increase of 1 °C was reached 10 ± 5 minutes into the treatment, and a more vigorous temperature increase of 4 °C was reached 80 ± 10 minutes into the treatment. The maximal steady-state IM temperatures produced during the final 60 minutes of treatment at the 1.5-cm depth were 4.42 °C ± 0.08 °C and 3.92 °C ± 0.06 °C using 1 and 2 transducers, respectively. At the 3.0-cm depth, the maximal steady-state IM temperatures during the final 60 minutes of treatment were 3.05 °C ± 0.09 °C and 3.17 °C ± 0.05 °C using 1 and 2 transducers, respectively. We observed a difference between the temperatures measured at each depth (t78 = -2.45, P = .02), but the number of transducers used to generate heating was not different (t78 = 1.79, P = .08). The LITUS device elicited tissue heating equivalent to traditional ultrasound but could be sustained for multiple hours. It is a safe and effective alternative tool

  7. A NOVA NARRATIVA ITALIANA UM AUTOR, UM SÍMBOLO: PIER VITTORIO TONDELLI

    Directory of Open Access Journals (Sweden)

    Lucia Sgobaro Zanette

    2016-01-01

    Full Text Available Na literatura italiana dos anos oitenta, uma série de autores produziram textos classificados pela crítica de a nova narrativa italiana. Pier Vittorio Tondelli, que escreveu romances, contos, crônicas, textos críticos e peças de teatro durante toda a década, tornou-se - com as suas temáticas inerentes a uma realidade pós-moderna e, principalmente, ligadas a certas experiências da juventude do final dos anos setenta até o começo dos anos noventa - um autor-ícone desse período. Com a sua maneira de viver como homem em movimento, seu agudo senso de observa- ção, sua escritura, seu estilo, seu ritmo e seu forte sentire, ele se revelou um símbolo dessa nova geração de escritores, que promoveram uma importante renovação da literatura italiana, libertando-a dos impasses que a condicionavam: a dificuldade de leitura da narrativa neovanguardista e experimental, a falta de espessura da literatura de consumo e a obviedade da literatura realista, que, todavia, os novos escritores valorizavam bastante. Palavras-chave: literatura italiana, anos oitenta, renovação.

  8. Nicolau Syndrome after Intramuscular Injection of Non-Steroidal Anti-Inflammatory Drugs (NSAID

    Directory of Open Access Journals (Sweden)

    Mehmet Dadaci

    2015-01-01

    Full Text Available Nicolau syndrome is a rare complication of intramuscular injection that leads to local ischemic necrosis of the skin and adipose tissue. In this paper, we discuss etiologies, risk factors, and treatment options for gluteal Nicolau syndrome referring to patients treated in our hospital. Our study includes 17 women who visited our clinic with symptoms of gluteal necrosis secondary to intramuscular injection. The following variables were taken into account: injection site, drug administered, frequency of injections, the person who administered the injections, needle size, and needle tip color. Magnetic resonance images obtained in the aftermath of intramuscular injection application were carefully analyzed for presence of necrosis, cyst formation and the thickness of the gluteal fat tissue layer. Drugs that had been received in intramuscular injection were exclusively non-steroidal anti-inflammatory drugs. Mean patient BMI was 41.8 (all patients were considered as obese, and mean gluteal fat thickness was 54 mm. Standard length of needles (3.8 cm had been used in procedures. The wounds were treated with primary closure in 11 patients and with local flap therapy in 6 patients. The observed necrosis was a consequence of misplaced gluteal injection, where drugs were injected into the adipose tissue instead of the muscle due to the extreme thickness of the fat layer, on one hand, and the inappropriate length of standard needles, on the other hand. Intramuscular injection should be avoided in obese patients whenever possible: if it is necessary, proper injection technique should be used.

  9. Does insertion of intramuscular electromyographic electrodes alter motor behavior during locomotion?

    Science.gov (United States)

    Armour Smith, Jo; Kulig, Kornelia

    2015-06-01

    Intramuscular electromyography (EMG) is commonly used to quantify activity in the trunk musculature. However, it is unclear if the discomfort or fear of pain associated with insertion of intramuscular EMG electrodes results in altered motor behavior. This study examined whether intramuscular EMG affects locomotor speed and trunk motion, and examined the anticipated and actual pain associated with electrode insertion in healthy individuals and individuals with a history of low back pain (LBP). Before and after insertion of intramuscular electrodes into the lumbar and thoracic paraspinals, participants performed multiple repetitions of a walking turn at self-selected and controlled average speed. Low levels of anticipated and actual pain were reported in both groups. Self-selected locomotor speed was significantly increased following insertion of the electrodes. At the controlled speed, the amplitude of sagittal plane lumbo-pelvic motion decreased significantly post-insertion, but the extent of this change was the same in both groups. Lumbo-pelvic motion in the frontal and axial planes and thoraco-lumbar motion in all planes were not affected by the insertions. This study demonstrates that intramuscular EMG is an appropriate methodology to selectively quantify the activation patterns of the individual muscles in the paraspinal group, both in healthy individuals and individuals with a history of LBP. Copyright © 2015 Elsevier Ltd. All rights reserved.

  10. FDG PET/CT and MR imaging of intramuscular myxoma in the gluteus maximus

    Directory of Open Access Journals (Sweden)

    Nishio Jun

    2012-06-01

    Full Text Available Abstract Intramuscular myxoma is a rare benign soft tissue tumor which may be mistaken for other benign and low-grade malignant myxoid neoplasms. We present the case of a 63-year-old woman with an asymptomatic intramuscular myxoma discovered incidentally on a whole-body F-18 fluorodeoxyglucose (FDG positron emission tomography (PET/computed tomography. PET images showed a mild FDG uptake (maximum standardized uptake value, 1.78 in the left gluteus maximus. Subsequent magnetic resonance (MR imaging revealed a well-defined ovoid mass with homogenous low signal intensity on T1-weighted sequences and markedly high signal intensity on T2-weighted sequences. Contrast-enhanced MR images showed heterogeneous enhancement throughout the mass. The diagnosis of intramuscular myxoma was confirmed on histopathology after surgical excision of the tumor. The patient had no local recurrence at one year follow-up. Our case suggests that intramuscular myxoma should be considered in the differential diagnosis of an oval-shaped intramuscular soft tissue mass with a mild FDG uptake.

  11. TDAH: um sintoma social

    Directory of Open Access Journals (Sweden)

    Giuliana Sorbara

    2017-03-01

    Full Text Available Ao longo da história médica a definição e a forma de se definir o diagnóstico do Transtorno do Déficit de Atenção e Hiperatividade (TDAH culminaram em uma medicalização excessiva e questionável de crianças participantes do cenário educacional. Essa medicalização da vida no ambiente escolar se realiza aliada a um processo histórico e social de normatização imposto pela biopolítica, e, consequentemente, um aumento de diagnósticos visando melhorar o desempenho do aluno. Christoph Türcke ao falar sobre os choques imagéticos auxilia na compreensão do TDAH. Para ele, o choque de imagens apresentadas pelos aparatos audiovisuais exerce uma fascinação estética que, ao fornecer sempre novas imagens, estabelece um espaço mental, em regime de atenção excessiva. Novos padrões de socialização, dessa forma, vão se sedimentando no que se pode denominar de uma mutação subjetiva ligada às imagens e, por conseguinte, medicalizada. Enfim, o TDAH encontra-se nesse espaço em que a criança que possui o déficit de atenção é a criança da cultura atual, denominada por cultura High-tech, em que os sintomas do TDAH são da sociedade contemporânea.

  12. The IDvIP trial: a two-centre randomised double-blind controlled trial comparing intramuscular diamorphine and intramuscular pethidine for labour analgesia.

    Science.gov (United States)

    Wee, Michael Y K; Tuckey, Jenny P; Thomas, Peter; Burnard, Sara

    2011-07-08

    Intramuscular pethidine is routinely used throughout the UK for labour analgesia. Studies have suggested that pethidine provides little pain relief in labour and has a number of side effects affecting mother and neonate. It can cause nausea, vomiting and dysphoria in mothers and can cause reduced fetal heart rate variability and accelerations. Neonatal effects include respiratory depression and impaired feeding. There are few large studies comparing the relative side effects and efficacy of different opioids in labour. A small trial comparing intramuscular pethidine with diamorphine, showed diamorphine to have some benefits over pethidine when used for labour analgesia but the study did not investigate the adverse effects of either opioid. The Intramuscular Diamorphine versus Intramuscular Pethidine (IDvIP) trial is a randomised double-blind two centre controlled trial comparing intramuscular diamorphine and pethidine regarding their analgesic efficacy in labour and their side effects in mother, fetus and neonate. Information about the trial will be provided to women in the antenatal period or in early labour. Consent and recruitment to the trial will be obtained when the mother requests opioid analgesia. The sample size requirement is 406 women with data on primary outcomes. The maternal primary outcomes are pain relief during the first 3 hours after trial analgesia and specifically pain relief after 60 minutes. The neonatal primary outcomes are need for resuscitation and Apgar Score analgesia, whether method of analgesia would be used again, use of Entonox, umbilical arterial and venous pH, fetal heart rate, meconium staining, time from delivery to first breath, Apgar scores at 5 mins, naloxone requirement, transfer to neonatal intensive care unit, neonatal haemoglobin oxygen saturation at 30, 60, 90, and 120 mins after delivery, and neonatal sedation and feeding behaviour during first 2 hours. If the trial demonstrates that diamorphine provides better analgesia

  13. D. Luís Pires : retalhos de vida de um prelado quatrocentista

    OpenAIRE

    Garrido, André

    2007-01-01

    D. Luís foi capelão em 1433, quando D. Duarte subiu ao trono, e era arcebispo de Braga quando morreu em 1480. Ao longo destes 43 anos foi embaixador régio, legado papal na Alemanha, bispo em três dioceses nacionais e responsável por um dos sínodos diocesanos mais importantes para o período medieval. No contexto nacional, foi testemunha directa dos momentos políticos que conduzirama Alfarrobeira. Já no âmbito europeu, foi um privilegiado espectador do despontar da arte e cultura renascentista ...

  14. Movimentos sociais digitais em Portugal: um estudo de caso múltiplo

    OpenAIRE

    Sousa, Adriana Patrícia Costa das Dôres

    2017-01-01

    Dissertação de mestrado, Educação Social, Escola Superior de Educação e Comunicação, Universidade do Algarve, 2017 Este trabalho de investigação pretende trazer um contributo importante para o estudo dos movimentos sociais digitais. A realidade deste tipo de movimentos é um fenómeno recente, embora, com tradição histórica nos movimentos sociais tradicionais sofrendo ao longo dos tempos novas reconfigurações. Outrora a luta dos movimentos sociais manifestava-se através de revoluções fazendo...

  15. Um gênero comunicacional: os boatos e as lendas urbanas

    OpenAIRE

    Université Paul Valéry/Montpelier III, Jean-Bruno Renard - Université Paul Valé

    2008-01-01

    Neste artigo, o autor pontua que é preciso analisar o grau de um boato na sociedade e estudar os mecanismos de distorção de fatos ou informações factuais. Para ele, no entanto, é muito importante entender como e por que são espalhadas notícias falsas que passam a merecer crédito. Renard acredita que boatos e narrativas populares contemporâneas são os equivalentes modernos de lendas antigas ao expressarem um pensamento social ou simbólico.

  16. Investigation of the mechanisms that influence the accretion of bovine intramuscular and subcutaneous adipose tissue

    International Nuclear Information System (INIS)

    Miller, M.F.

    1987-01-01

    The understanding of the mechanisms that differ between breeds of cattle and their ability to deposit intramuscular adipose tissue is imperative to profitable beef production. Thus, the interactions among breeds, metabolic substrates and specific hormones in bovine intramuscular and subcutaneous adipose tissue were investigated. Subcutaneous and intramuscular adipose tissues were obtained from 10 Angus and 9 Santa Gertrudis steers immediately postmortem. The adipose tissues were incubated for 2 h and 48 h with and without 1 mU/ml insulin and 30 mg/ml bovine serum albumin (BSA) to measure the incorporation of 14 C-labeled acetate and glucose into lipid fractions. At the same chronological age, Angus steers had a more youthful lean maturity score, higher USDA marbling scores and higher USDA quality grades than carcasses from Santa Gertrudis steers

  17. Efficacy and Tolerability of Intramuscular Dexketoprofen in Postoperative Pain Management following Hernia Repair Surgery.

    Science.gov (United States)

    Jamdade, P T; Porwal, A; Shinde, J V; Erram, S S; Kamat, V V; Karmarkar, P S; Bhagtani, K; Dhorepatil, S; Irpatgire, R; Bhagat, H; Kolte, S S; Shirure, P A

    2011-01-01

    Objective. To evaluate the safety and efficacy of intramuscular dexketoprofen for postoperative pain in patients undergoing hernia surgery. Methodology. Total 202 patients received single intramuscular injection of dexketoprofen 50 mg or diclofenac 50 mg postoperatively. The pain intensity (PI) was self-evaluated by patients on VAS at baseline 1, 2, 4, 6, and 8 hours. The efficacy parameters were number of responders, difference in PI (PID) at 8 hours, sum of analogue of pain intensity differences (SAPID), and onset and duration of analgesia. Tolerability assessment was done by global evaluation and adverse events in each group. Results. Dexketoprofen showed superior efficacy in terms of number of responders (P = .007), PID at 8 hours (P = .02), and SAPID( 0-8 hours ) (P dexketoprofen trometamol 50 mg given intramuscularly provided faster, better, and longer duration of analgesia in postoperative patients of hernia repair surgery than diclofenac 50 mg, with comparable safety.

  18. Nitrocobinamide, a New Cyanide Antidote That Can Be Administered by Intramuscular Injection

    Science.gov (United States)

    Chan, Adriano; Jiang, Jingjing; Fridman, Alla; Guo, Ling T.; Shelton, G. Diane; Liu, Ming-Tao; Green, Carol; Haushalter, Kristofer J.; Patel, Hemal H.; Lee, Jangwoen; Yoon, David; Burney, Tanya; Mukai, David; Mahon, Sari B.; Brenner, Matthew; Pilz, Renate B.; Boss, Gerry R.

    2015-01-01

    Currently available cyanide antidotes must be given by intravenous injection over 5–10 min, making them illsuited for treating many people in the field, as could occur in a major fire, an industrial accident, or a terrorist attack. These scenarios call for a drug that can be given quickly, e.g., by intramuscular injection. We have shown that aquohydroxocobinamide is a potent cyanide antidote in animal models of cyanide poisoning, but it is unstable in solution and poorly absorbed after intramuscular injection. Here we show that adding sodium nitrite to cobinamide yields a stable derivative (referred to as nitrocobinamide) that rescues cyanide-poisoned mice and rabbits when given by intramuscular injection. We also show that the efficacy of nitrocobinamide is markedly enhanced by coadministering sodium thiosulfate (reducing the total injected volume), and we calculate that ∼1.4 mL each of nitrocobinamide and sodium thiosulfate should rescue a human from a lethal cyanide exposure. PMID:25650735

  19. Staphylococcus cohnii spp urealyticus: relato de caso de um patógeno incomum

    OpenAIRE

    d'Azevedo,Pedro Alves; Antunes,Ana Lúcia Sousa; Martino,Marinês Dalla Valle; Pignatari,Antonio Carlos Campos

    2008-01-01

    Staphylococcus coagulase negativos tem surgido como importantes agentes em infecções de pacientes hospitalizados. Neste estudo, relatamos o caso de bacteremia associada a cateter venoso central devido a Staphylococcus cohnii spp urealyticus isolado em hemocultura de um paciente do sexo masculino, 53 anos, internado em hospital geral da cidade de São Paulo. Discutimos nesse relato a dificuldade em identificar rotineiramente esse microrganismo no Laboratório de Microbiologia Clínica. Staphyloco...

  20. Propriedades magnéticas de organismos magnetotácticos: um trabalho multidisciplinar

    OpenAIRE

    Margato,Bianca; Santos,Maylla dos; Barros,Henrique Lins de

    2007-01-01

    Medidas do momento magnético de microorganismos magnetotácticos foram realizadas a partir do estudo de movimento de células no meio aquoso. Essas medidas fornecem informações importantes para a compreensão de processos adaptativos dos seres vivos. O presente trabalho oferece uma técnica que pode ser aplicada no ensino de física, biologia ou ecologia e é um exemplo de pesquisa multidisciplinar.

  1. Intramuscular tendon involvement on MRI has limited value for predicting time to return to play following acute hamstring injury.

    Science.gov (United States)

    van der Made, Anne D; Almusa, Emad; Whiteley, Rod; Hamilton, Bruce; Eirale, Cristiano; van Hellemondt, Frank; Tol, Johannes L

    2018-01-01

    Hamstring injury with intramuscular tendon involvement is regarded as a serious injury with a delay in return to play (RTP) of more than 50 days and reinjury rates up to 63%. However, this reputation is based on retrospective case series with high risk of bias. Determine whether intramuscular tendon involvement is associated with delayed RTP and elevated rates of reinjury. MRI of male athletes with an acute hamstring injury was obtained within 5 days of injury. Evaluation included standardised MRI scoring and scoring of intramuscular tendon involvement. Time to RTP and reinjury rate were prospectively recorded. Out of 70 included participants, intramuscular tendon disruption was present in 29 (41.4%) injuries. Injuries without intramuscular tendon disruption had a mean time to RTP of 22.2±7.4 days. Injuries with Injuries with full-thickness disruption took longer to RTP compared with injuries without disruption (p=0.025). Longitudinal intramuscular tendon disruption was not significantly associated with time to RTP. Waviness was present in 17 (24.3%) injuries. Mean time to RTP for injuries without and with waviness was 22.6±7.5 and 30.2±10.8 days (p=0.014). There were 11 (15.7%) reinjuries within 12 months, five (17.2%) in the group with intramuscular tendon disruption and six (14.6%) in the group without intramuscular tendon disruption. Time to RTP for injuries with full-thickness disruption of the intramuscular tendon and waviness is significantly longer (by slightly more than 1 week) compared with injuries without intramuscular tendon involvement. However, due to the considerable overlap in time to RTP between groups with and without intramuscular tendon involvement, its clinical significance for the individual athlete is limited. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  2. Systemic and local immune response in pigs intradermally and intramuscularly injected with inactivated Mycoplasma hyopneumoniae vaccines.

    Science.gov (United States)

    Martelli, P; Saleri, R; Cavalli, V; De Angelis, E; Ferrari, L; Benetti, M; Ferrarini, G; Merialdi, G; Borghetti, P

    2014-01-31

    The systemic and respiratory local immune response induced by the intradermal administration of a commercial inactivated Mycoplasma hyopneumoniae whole-cell vaccine (Porcilis(®) MHYO ID ONCE - MSD AH) in comparison with two commercial vaccines administered via the intramuscular route and a negative control (adjuvant only) was investigated. Forty conventional M. hyopneumoniae-free pigs were randomly assigned to four groups (ten animals each): Group A=intradermal administration of the test vaccine by using the needle-less IDAL(®) vaccinator at a dose of 0.2 ml; Group B=intramuscular administration of a commercially available vaccine (vaccine B); Group C=intramuscular administration of the adjuvant only (2 ml of X-solve adjuvant); Group D=intramuscular administration of a commercially available vaccine (vaccine D). Pigs were vaccinated at 28 days of age. Blood and bronchoalveolar lavage (BAL) fluid samples were collected at vaccination (blood only), 4 and 8 weeks post-vaccination. Serum and BAL fluid were tested for the presence of antibodies by ELISA test. Peripheral blood monomorphonuclear cells (PBMC) were isolated to quantify the number of IFN-γ secreting cells by ELISpot. Moreover, cytokine gene expression from the BAL fluid was performed. Total antibodies against M. hyopneumoniae and specific IgG were detected in serum of intradermally and intramuscularly (vaccine B only) vaccinated pigs at 4 and 8 weeks post-vaccination. M. hyopneumoniae specific IgA were detected in BAL fluid from vaccinated animals (Groups A and B) but not from controls and animals vaccinated with the bacterin D (padministration of an adjuvanted bacterin induces both systemic and mucosal immune responses. Moreover, the intramuscularly administered commercial vaccines each had a different ability to stimulate the immune response both systemically and locally. Copyright © 2013 Elsevier B.V. All rights reserved.

  3. Fibrous Myopathy as a Complication of Repeated Intramuscular Injections for Chronic Headache

    Directory of Open Access Journals (Sweden)

    R Burnham

    2006-01-01

    Full Text Available Two cases of fibrous myopathy associated with repeated, long-term intramuscular injections for treatment of chronic temporomandibular joint pain and chronic headache, respectively, are described. Both patients developed severe, function-limiting contractures in upper and lower extremity muscles used as injection sites. In one of the cases, the contractures were painful. Electrophysiological testing, magnetic resonance imaging and muscle biopsy results were all consistent with myopathy and replacement of skeletal muscle with noncontractile fibrous tissue. These cases are presented to increase awareness of fibrous myopathy and to promote surveillance for this serious potential complication of long-term intramuscular injections in chronic headache and other pain patients.

  4. Associations of heart and adipocyte fatty acid-binding protein gene expression with intramuscular fat content in pigs

    NARCIS (Netherlands)

    Gerbens, F.; Verburg, F.J.; Moerkerk, van H.T.; Engel, B.; Buist, W.; Veerkamp, J.H.; Pas, te M.F.

    2001-01-01

    Intramuscular fat content is a major determinant of meat quality in pigs. Previously, polymorphisms in the adipocyte and heart fatty acid-binding protein genes, A-FABP and H-FABP, have been significantly associated with genetic variation of intramuscular fat content in a Duroc pig population.

  5. Associations of heart and adipocyte fatty acid-binding protein gene expression with intramuscular fat content in pigs.

    NARCIS (Netherlands)

    Gerbens, F.; Verburg, F.J.; Moerkerk, H.T.B. van; Engel, B.; Buist, W.; Veerkamp, J.H.; Pas, M.F. te

    2001-01-01

    Intramuscular fat content is a major determinant of meat quality in pigs. Previously, polymorphisms in the adipocyte and heart fatty acid-binding protein genes, A-FABP and H-FABP, have been significantly associated with genetic variation of intramuscular fat content in a Duroc pig population.

  6. Fatores considerados pela população como mais importantes para manutenção da saúde Factores considerados por la población como más importantes para el mantenimiento de la salud Factors considered important for health maintenance by the population

    Directory of Open Access Journals (Sweden)

    Fernando Vinholes Siqueira

    2009-12-01

    Full Text Available OBJETIVO: Analisar os fatores que adultos e idosos consideram como mais importantes para manutenção da saúde. MÉTODOS: Estudo transversal realizado com 4.060 adultos e 4.003 idosos residentes em áreas de abrangência de 240 unidades básicas de saúde das regiões Sul e Nordeste, em 2005. Um cartão com figuras e frases referentes a sete fatores relacionados com o risco de doenças e agravos não transmissíveis era mostrado aos indivíduos para que indicassem o fator mais relevante para a saúde. Os fatores eram: manter uma alimentação saudável, fazer exercício físico regularmente, não tomar bebidas alcoólicas em excesso, realizar consultas médicas regularmente, não fumar, manter o peso ideal e controlar ou evitar o estresse. As análises foram ajustadas por regressão de Poisson com cálculo de razões de prevalência ajustadas, intervalos com 95% de confiança, e valores de significância usando os Testes de Wald para heterogeneidade e tendência linear. RESULTADOS: Os fatores mais freqüentemente indicados pelos adultos foram: alimentação saudável (33,8%, realizar exercício físico (21,4% e não fumar (13,9%. Entre os idosos, os fatores mais relatados foram: alimentação saudável (36,7%, não fumar (17,7% e consultar o médico regularmente (14,2%. Foram observadas diferenças entre os fatores citados conforme a região geográfica, variáveis demográficas, socioeconômicas e de saúde. CONCLUSÕES: A maioria de adultos e idosos, de ambas regiões, reconhece e indica a necessidade de manter uma alimentação saudável e de não fumar como medidas mais importantes para manutenção da saúde. Estratégias de educação em saúde devem considerar essas características dos indivíduos para estimular medidas específicas a serem adotadas para cada segmento populacional.OBJETIVO: Analizar los factores que adultos y ancianos consideran como más importantes para mantenimiento de la salud. MÉTODOS: Estudio transversal

  7. Microstructure alterations in beef intramuscular connective tissue caused by hydrodynamic pressure processing

    Science.gov (United States)

    Scanning electron microscopy (SEM) was utilized to evaluate microstructural changes in intramuscular connective tissue of beef semimembranosus muscle subjected to hydrodynamic pressure processing (HDP). Samples were HDP treated in a plastic container (HDP-PC) or a steel commercial unit (HDP-CU). C...

  8. Role of ultrasonography and magnetic resonance imaging in the diagnosis of intramuscular cysticercosis

    Energy Technology Data Exchange (ETDEWEB)

    Tripathy, Sujit Kumar [Postgraduate Institute of Medical Education and Research, Department of Orthopedics, Chandigarh (India); Friarage Hospital, Department of Orthopedics, Northallerton (United Kingdom); Sen, Ramesh Kumar; Akkina, Narendranadh; Hampannavar, Aravind; Tahasildar, Naveen [Postgraduate Institute of Medical Education and Research, Department of Orthopedics, Chandigarh (India); Limaye, Rajiv [Friarage Hospital, Department of Orthopedics, Northallerton (United Kingdom)

    2012-09-15

    Nonspecific clinical presentations often lead to misdiagnosis of focal cysticercal myositis. This report emphasizes the role of ultrasonography and magnetic resonance imaging (MRI) in the diagnosis of solitary intramuscular cysticercosis. Six patients with persistent post-traumatic isolated muscular swelling were treated with analgesic and antibiotics, but the swelling did not subside. Radiographs showed soft tissue swelling with no bony abnormalities. Laboratory markers were inconclusive. Ultrasonographic and magnetic resonance images (MRI) showed typical features of intramuscular cysticercosis. Clinical, radiological, and fundoscopic evaluation of brain and eyes could not isolate any cysticercosis focus in these organs. Patients were treated with 3 weeks albendazole therapy. The identifying sonographic features of intramuscular cysticercosis, as evident from this case series, included an intramuscular elliptical or oval anechoic lesion with echogenic intralesional focus likely to be scolex. Magnetic resonance images showed orientation of the cyst along the direction of muscle fibers with T2W hyperintense signal and post-contrast perilesional enhancement. All patients responded to medical treatment. Cysticercosis may manifest as isolated muscular swelling without neurological or ocular involvement. Clinicians should be aware of this clinical condition to avoid misdiagnosis. Ultrasonography and magnetic resonance imaging are good diagnostic aids to establish soft tissue cysticercosis. (orig.)

  9. Weekly Intramuscular Injection of Levothyroxine following Myxoedema: A Practical Solution to an Old Crisis

    Directory of Open Access Journals (Sweden)

    Peter N. Taylor

    2015-01-01

    Full Text Available An 82-year-old female with known hypothyroidism was admitted to hospital after being found on the floor. On examination, she was unkempt, confused, bradycardic, hypothermic, and barely arousable. Initial biochemistry revealed a thyroid stimulating hormone (TSH of >100 mU/L and free thyroxine (FT4 level of 1.5 pmol/L which supported a diagnosis of myxoedema coma. She was resuscitated and commenced on liothyronine, levothyroxine, and hydrocortisone and some improvement was made. It became apparent that she was hiding and spitting out her oral levothyroxine including levothyroxine elixir. Given the need for prompt alternative control, we sought advice from international experts where intramuscular levothyroxine was recommended. She was managed from day 50 onwards with intramuscular levothyroxine 200 mcg once a week, which was subsequently increased to 500 mcg. Thyroid function normalized and she made continual cognitive and physical progress and was discharged to a rehabilitation hospital. Her intramuscular levothyroxine was stopped and she was subsequently restarted on oral levothyroxine, with a plan for on-going close monitoring of her thyroid function. This report highlights the potential to use intramuscular levothyroxine in individuals with severe hypothyroidism arising from poor compliance with levothyroxine treatment or other potential causes such as impaired absorption.

  10. Depletion of penicillin G residues in heavy sows after intramuscular injection. Part I: Tissue residue depletion

    Science.gov (United States)

    Heavy sows (n=126) were treated with penicillin G procaine at a 5x label dose (33,000 IU/kg) for 3 consecutive days by intramuscular (IM) injection using 3 separate patterns (treatments) of drug administration (42 sows per treatment). Treatments differed by pattern and maximum injection volume per s...

  11. Fluorine-18 fluorodeoxyglucose positron emission tomography-computed tomography in evaluation of residual intramuscular myxoma

    International Nuclear Information System (INIS)

    Zade, Anand; Ahire, Archana; Shetty, Shishir; Rai, Sujith; Bokka, Rajashekharrao; Velumani, Arokiaswamy; Kabnurkar, Rasika

    2015-01-01

    Intramuscular myxoma (IM) is a rare benign neoplasm. In a patient diagnosed with IM of left thigh, we report the utility of a postoperative fluorine-18 fluorodeoxyglucose positron emission tomography-computed tomography scan in assessing the efficacy of surgical excision

  12. MMR vaccine in 14 months old children, intramuscular versus subcutaneous administration

    NARCIS (Netherlands)

    Lafeber AF; Klis FRM van der; Marzec AHJO; Labadie J; Ommen R van; Strieder TG; Berbers GAM; Utrecht Stichting Thuiszorg; Amersfoort Stichting Thuiszorg Eemland (STE),; LVO

    2001-01-01

    In this study we compared the recommended subcutaneous administration of the RIVM MMR vaccine with the intramuscular administration for both safety and immunogenicity. Study subjects were 14 months old children, living in Amersfoort or Utrecht, who were eligible for their first MMR vaccination.

  13. Intramuscular dissection of a large ganglion cyst into the gastrocnemius muscle.

    Science.gov (United States)

    Nicholson, Luke T; Freedman, Harold L

    2012-07-01

    Ganglion cysts are lesions resulting from the myxoid degeneration of the connective tissue associated with joint capsules and tendon sheaths. Most common around the wrist joint, ganglion cysts may be found elsewhere in the body, including in and around the knee joint. Uncommonly, ganglion cysts can present intramuscularly. Previous reports document the existence of intramuscular ganglia, often without histologic confirmation. This article describes a case of an intramuscular ganglion cyst in the medial gastrocnemius muscle of a 53-year-old woman. The patient initially presented for discomfort associated with the lesion. Examination was consistent with intramuscular cystic lesion of unknown etiology. Ultrasound and magnetic resonance imaging revealed the origin of the mass at the semimembranosus-gastrocnemius bursa. Because of its location, the mass was initially suspected to be a dissecting Baker's cyst, an uncommon but previously reported diagnosis. The patient underwent surgical excision, and examination of the intact specimen revealed a thin, fibrous, walled cyst with no lining epithelium, which was consistent with a ganglion cyst. To the authors' knowledge, this is the first report in the orthopedic literature of a ganglion cyst dissecting into the gastrocnemius muscle. Because ganglion cysts commonly require excision for definitive treatment and do not respond well to treatment measures implemented for Baker's cysts, including resection of underlying meniscal tears, the authors believe it is important for orthopedic surgeons to be able to distinguish between Baker's and other cysts associated with the knee joint, including ganglion cysts, which may require more definitive treatment. Copyright 2012, SLACK Incorporated.

  14. Florfenicol concentrations in milk of lactating cows postreated by intramuscular or intramammary routes

    Directory of Open Access Journals (Sweden)

    John Ruiz B

    2010-08-01

    Full Text Available intramammary administration to establish the optimum withdrawal time, therapeutic efficacy, and its influence on milk yield. Materials and method. Twelve healthy lactating Holstein cows were selected from the University of Antioquia’s teaching dairy herd (Colombia, were randomly assigned to a control (n=6 group or florfenicol (n=6 group that received 20 mg/kg of florfenicol by intramammary and intramuscular routes, with a 15 days washout period between treatments. Results. The Tmax and Cmax for the intramuscular route were 6 hoursand 2.86 mg/L respectively. The Tmax and Cmax for the intramammary route, were estimated at 0 hour and about 20000 mg/L respectively by extrapolated from regression line. The florfenicol elimination phase in milk had an average half-life of elimination (t½ of 19.8 hours and 4.9 hours for intramuscular and intramammary administration, respectively. The therapeutic efficacy only was reached by intramammary route, when minimal inhibitory concentration (M.I.C. of florfenicol by Stahphylococcus aureus, was used as reference value. There was no statistically significant difference in milk yield between treated and non-treated cows. Conclusions. According to these results, post-treatment milk withdrawal should be no less than 3 days for intramammary administration, and at least 7 days for intramuscular administration. The therapeutic efficacy only was reached by intramammary route. In addition, there was no statistically significant difference in milk yield between treated and nontreated cows.

  15. Intramuscular Lipoma-Induced Occipital Neuralgia on the Lesser Occipital Nerve.

    Science.gov (United States)

    Han, Hyun Ho; Kim, Hak Soo; Rhie, Jong Won; Moon, Suk Ho

    2016-06-01

    Occipital neuralgia (ON) is commonly characterized by a neuralgiform headache accompanied by a paroxysmal burning sensation in the dermatome area of the greater, lesser, or third occipital nerve. The authors report a rare case of ON caused by an intramuscular lipoma originating from the lesser occipital nerve.A 52-year-old man presented with sharp pain in the left postauricular area with a 3 × 2-cm palpable mass. Computed tomography revealed a mass suspiciously resembling an intramuscular lipoma within splenius muscle. In the operation field, a protruding mass causing stretching of the lesser occipital nerve was found. After complete resection, the neuralgiform headache symptom had resolved and the intramuscular lipoma was confirmed through histopathology.Previous studies on the causes of ON have reported that variation in normal anatomic structures results in nerve compression. Occipital neuralgia, however, caused by intramuscular lipomas in splenius muscles have not been previously reported, and the dramatic resolution following surgery makes it an interesting case worth reporting.

  16. The experience of intramuscular benzathine penicillin for prophylaxis of recurrent cellulitis: A cohort study

    Directory of Open Access Journals (Sweden)

    Hsien-Meng Chen

    2017-10-01

    Conclusion: Intramuscular benzathine penicillin at a 4-week interval may be an effective prophylactic strategy to reduce the incidence of cellulitis. Further studies are necessary to determine the factors associated with failure of prophylaxis as well as optimal individualized dosage and dosing interval of the prophylactic agent.

  17. Role of ultrasonography and magnetic resonance imaging in the diagnosis of intramuscular cysticercosis

    International Nuclear Information System (INIS)

    Tripathy, Sujit Kumar; Sen, Ramesh Kumar; Akkina, Narendranadh; Hampannavar, Aravind; Tahasildar, Naveen; Limaye, Rajiv

    2012-01-01

    Nonspecific clinical presentations often lead to misdiagnosis of focal cysticercal myositis. This report emphasizes the role of ultrasonography and magnetic resonance imaging (MRI) in the diagnosis of solitary intramuscular cysticercosis. Six patients with persistent post-traumatic isolated muscular swelling were treated with analgesic and antibiotics, but the swelling did not subside. Radiographs showed soft tissue swelling with no bony abnormalities. Laboratory markers were inconclusive. Ultrasonographic and magnetic resonance images (MRI) showed typical features of intramuscular cysticercosis. Clinical, radiological, and fundoscopic evaluation of brain and eyes could not isolate any cysticercosis focus in these organs. Patients were treated with 3 weeks albendazole therapy. The identifying sonographic features of intramuscular cysticercosis, as evident from this case series, included an intramuscular elliptical or oval anechoic lesion with echogenic intralesional focus likely to be scolex. Magnetic resonance images showed orientation of the cyst along the direction of muscle fibers with T2W hyperintense signal and post-contrast perilesional enhancement. All patients responded to medical treatment. Cysticercosis may manifest as isolated muscular swelling without neurological or ocular involvement. Clinicians should be aware of this clinical condition to avoid misdiagnosis. Ultrasonography and magnetic resonance imaging are good diagnostic aids to establish soft tissue cysticercosis. (orig.)

  18. Differences in intramuscular vascular connections of human and dog latissimus dorsi muscles.

    Science.gov (United States)

    Yang, D; Morris, S F

    1999-02-01

    Distal ischemia and necrosis of the dog latissimus dorsi muscle flap used in experimental cardiomyoplasty have been reported. However, little information on the intramuscular vascular anatomy of the dog latissimus dorsi is available. It is unclear whether there are any anatomic factors relating to the muscle flap ischemia and necrosis, and whether the dog latissimus dorsi is a suitable experimental model. To study the intramuscular vascular territories in the dog latissimus dorsi muscle, and to compare the intramuscular vasculature of the dog with that of the human, 5 fresh dog cadavers and 7 fresh human cadavers were injected with a mixture of lead oxide, gelatin, and water (200 mL/kg) through the carotid artery. Both the dog and the human latissimus dorsi muscles and neurovascular pedicles were dissected and radiographed. The intramuscular vascular anatomy of the latissimus dorsi muscles was compared. Radiographs demonstrate clearly that the pattern of latissimus dorsi intramuscular anastomoses between branches of the thoracodorsal artery and the perforators of posterior intercostal arteries in the proximal half of the muscle are different between the dog and the human. In the dog muscle, vascular connections between the thoracodorsal artery and the posterior intercostal arteries are formed by reduced-caliber choke arteries, whereas four to six true anastomoses without a change in caliber between them are found in the human muscle. The portion of the latissimus dorsi muscle supplied by the dominant thoracodorsal vascular territory was 25.9% +/- 0.3% in the dog and 23.9% +/- 0.5% in the human. For further comparison, an extended vascular territory in the latissimus dorsi muscle was demonstrated, including both the thoracodorsal territory and the posterior intercostal territories. The area of the extended vascular territory was 52% +/- 0.5% of the total muscle. The dog latissimus dorsi model may not be a perfect predictor of the behavior of the human latissimus

  19. Effect of Salted Ice Bags on Surface and Intramuscular Tissue Cooling and Rewarming Rates.

    Science.gov (United States)

    Hunter, Eric J; Ostrowski, Jennifer; Donahue, Matthew; Crowley, Caitlyn; Herzog, Valerie

    2016-02-01

    Many researchers have investigated the effectiveness of different cryotherapy agents at decreasing intramuscular tissue temperatures. However, no one has looked at the effectiveness of adding salt to an ice bag. To compare the cooling effectiveness of different ice bags (wetted, salted cubed, and salted crushed) on cutaneous and intramuscular temperatures. Repeated-measures counterbalanced design. University research laboratory. 24 healthy participants (13 men, 11 women; age 22.46 ± 2.33 y, height 173.25 ± 9.78 cm, mass 74.51 ± 17.32 kg, subcutaneous thickness 0.63 ± 0.27 cm) with no lower-leg injuries, vascular diseases, sensitivity to cold, compromised circulation, or chronic use of NSAIDs. Ice bags made of wetted ice (2000 mL ice and 300 mL water), salted cubed ice (intervention A; 2000 mL of cubed ice and 1/2 tablespoon of salt), and salted crushed ice (intervention B; 2000 mL of crushed ice and 1/2 tablespoon of salt) were applied to the posterior gastrocnemius for 30 min. Each participant received all conditions with at least 4 d between treatments. Cutaneous and intramuscular (2 cm plus adipose thickness) temperatures of nondominant gastrocnemius were measured during a 10-min baseline period, a 30-min treatment period, and a 45-min rewarming period. Differences from baseline were observed for all treatments. The wetted-ice and salted-cubed-ice bags produced significantly lower intramuscular temperatures than the salted-crushed-ice bag. Wetted-ice bags produced the greatest temperature change for cutaneous tissues. Wetted- and salted-cubed-ice bags were equally effective at decreasing intramuscular temperature at 2 cm subadipose. Clinical practicality may favor salted-ice bags over wetted-ice bags.

  20. Intramuscular Cobinamide Sulfite in a Rabbit Model of Sub-Lethal Cyanide Toxicity

    Science.gov (United States)

    Brenner, Matthew; Kim, Jae G.; Mahon, Sari B.; Lee, Jangwoen; Kreuter, Kelly A.; Blackledge, William; Mukai, David; Patterson, Steve; Mohammad, Othman; Sharma, Vijay S.; Boss, Gerry R.

    2009-01-01

    Objective To determine the ability of an intramuscular cobinamide sulfite injection to rapidly reverse the physiologic effects of cyanide toxicity. Background Exposure to cyanide in fires and industrial exposures and intentional cyanide poisoning by terrorists leading to mass casualties is an ongoing threat. Current treatments for cyanide poisoning must be administered intravenously, and no rapid treatment methods are available for mass casualty cyanide exposures. Cobinamide is a cobalamin (vitamin B12) analog with an extraordinarily high affinity for cyanide that is more water-soluble than cobalamin. We investigated the use of intramuscular cobinamide sulfite to reverse cyanide toxicity induced physiologic changes in a sublethal cyanide exposure animal model. Methods New Zealand white rabbits were given 10 mg sodium cyanide intravenously over 60 minutes. Quantitative diffuse optical spectroscopy and continuous wave near infrared spectroscopy monitoring of tissue oxy- and deoxyhemoglobin concentrations were performed concurrently with blood cyanide level measurements and cobinamide levels. Immediately after completion of the cyanide infusion, the rabbits were injected intramuscularly with cobinamide sulfite (n=6) or inactive vehicle (controls, n=5). Results Intramuscular administration led to rapid mobilization of cobinamide and was extremely effective at reversing the physiologic effects of cyanide on oxyhemoglobin and deoxyhemoglobin extraction. Recovery time to 63% of their baseline values in the central nervous system was in a mean of 1032 minutes in the control group and 9 minutes in the cobinamide group with a difference of 1023 minutes (95% confidence interval [CI] 116, 1874 minutes). In muscle tissue, recovery times were 76 and 24 minutes with a difference of 52 minutes (95% CI 7, 98min). Red blood cell cyanide levels returned towards normal significantly faster in cobinamide sulfite-treated animals than in control animals. Conclusions Intramuscular

  1. Contenidos de isómeros trans de los ácidos grasos en productos cárnicos. (III Tejido adiposo y grasa intramuscular de vacuno

    Directory of Open Access Journals (Sweden)

    Lluch, M. C.

    1993-06-01

    polinsaturados, en el tejido muscular. Los contenidos de ácidos grasos trans muestran diferencias significativas entre ambos tejidos (medias del 7% de ácidos trans totales en grasa intramuscular y 10.5% en grasa de depósito. El C18: 1t presenta una distribución paralela a la del total de ácidos trans, mientras que para el C16: 1 trans se observa un comportamiento claramente diferente, ya que no se presentan estas diferencias significativas entre ambos tejidos. En cuanto a los factores estudiados que pueden influir en el contenido de isómeros trans, cabe destacar que la raza fue aquél que ofrecía más diferencias, mientras que entre los diversos orígenes (explotaciones ganaderas y entre categorías de canal se presentaron menos diferencias en relación a los contenidos de estos isómeros. También es importante destacar que las correlaciones que se han observado entre los contenidos de ácidos trans y los totales de ácidos saturados, mono y polinsaturados presentan un signo contrario, según el tipo de tejido. Así, un aumento del % de ácidos trans va aparejado con un aumento de saturados y una disminución de polinsaturados en el tejido muscular, mientras que va aparejado con una disminución de saturados y un aumento de mono y polinsaturados en el tejido adiposo.

  2. Um mundo de cores

    Directory of Open Access Journals (Sweden)

    Elis Artz

    2016-08-01

    Full Text Available A pintura de Elis Artz é feita com muita alma e transborda alegria. A vitalidade de seu trabalho transparece nas cores fortes e nos traços simples e harmoniosos. Confira o trabalho da artista nesta edição da Revista Jangada. ELIS by ELIS Descobri meu talento artístisco e criativo há uns 25 anos. Nasci no Brasil e me mudei para os EUA 10 anos atrás por puro amor. Embora seja psicóloga de formação, o meu apreço pela pintura só cresceu e, com o passar dos anos, a paixão pelas tintas me direcionou a fazer cursos com artistas brasileiros renomados. Já morando nos EUA e com essa grande paixão adormecida, durante anos, decidi me entregar para as cores que sempre me trouxeram alegria e cor para os meus dias. Embora muitas de minhas pinturas tenham ido para minha família e amigos no Brasil, vendi inúmeras outras pelo país através de exposições em galerias de arte. Em 2014, fui uma das artistas em destaque no MTD ART nos Estados Unidos. Minha obra estava dentro de cada ônibus das cidades de Champaign e Urbana e exposta em destaque na Estação de Trem. Em maio de 2015, tive o prazer de ter outro trabalho meu nos outdoors da cidade, destacando a minha tela 'Frida' o ano inteiro e de expor em conjunto com alguns artistas locais no final de outubro. Desde então, tenho pintado cada vez mais e me interessado em divulgar o meu trabalho. E, como diria um amigo meu "Elis, você me mostrou que a vida não é só preto no branco". Ele estava certo.

  3. Kinetics of sup(99m)Tc-EHDP administered by intramuscular injection in man and in experimental animals

    Energy Technology Data Exchange (ETDEWEB)

    Vattimo, A.; Lore, F.; Pisani, M.

    1981-06-01

    With the aim of assessing the kinetics of a diphosphonate administered by intramuscular injection, we have studied the behaviour of sup(99m)Tc-labelled 1-hydroxy-1, 1-diphosphonate in man and in experimental animals, after intramuscular injection. The curves of plasma and urine radioactivity were analyzed in a six-compartment kinetic model containing seven transition coefficients. The results show that the diphosphonate given by intramuscular injection is absorbed rapidly and completely. Therefore the possibility of using this way of administration should be considered in the pathological conditions in which diphosphonates are used as therapeutic agents.

  4. Avaliação da buprenorfina pelas vias intravenosa ou intramuscular em cães anestesiados pelo desfluorano

    Directory of Open Access Journals (Sweden)

    Souza Almir Pereira de

    2004-01-01

    Full Text Available Objetivou-se avaliar comparativamente os efeitos da buprenorfina, administrada pelas vias intramuscular(IM ou intravenosa (IV, sobre variáveis cardiovasculares, em cães anestesiados com desfluorano. Para tanto, foram utilizados dezesseis cães adultos, clinicamente saudáveis, distribuídos em dois grupos (n=8 denominados de GI e GII. Em ambos os grupos, a anestesia foi induzida com propofol (8 mg/kg, IV e em seguida os animais foram intubados com sonda orotraqueal de Magill, a qual foi conectada ao aparelho de anestesia volátil para administração de desfluorano (1,5 CAM. Após 30 minutos do início da anestesia inalatória, foi aplicado no GI buprenorfina na dose de 0,02 mg/kg pela via IV, enquanto no GII administrou-se o opióide na mesma dose porém pela via IM. Avaliaram-se: freqüência cardíaca (FC; pressões arteriais sistólica, diastólica e média (PAS, PAD e PAM; débito cardíaco (DC; pressão venosa central (PVC e pressão da artéria pulmonar (PAP. As colheitas foram feitas nos seguintes momentos: M1 - 30 minutos após o início da anestesia inalatória antes da aplicação do opióide; M2 - 15 minutos após a administração da buprenorfina; M3, M4 e M5 - de 15 em 15 minutos após M2. A avaliação estatística dos dados foi efetuada por meio de Análise de Perfil (p<0,05. As variáveis PAS, PAM, DC, PVC e PAP, não apresentaram alterações significativas de seus valores em ambos os grupos. Entretanto, a FC e a PAD apresentaram reduções significativas após a administração do opióide apenas no GI. Assim, pôde-se concluir que a buprenorfina administrada pelas vias IV ou IM não interferiu nos índices cardiovasculares de forma a manifestar efeitos clínicos importantes em cães anestesiados com desfluorano.

  5. Centro histórico como território turístico criativo: um estudo em um destino turístico internacional no Brasil

    Directory of Open Access Journals (Sweden)

    Magnus Luiz Emmendoerfer

    2016-08-01

    Full Text Available O objetivo é analisar os elementos que possibilitam qualificar um centro histórico como um Território Turístico Criativo (TTC. Para realizar esta investigação, a cidade de Ouro Preto, Minas Gerais, Brasil, foi escolhida por ser um destino turístico internacional e por ser reconhecida mundialmente pela Organização das Nações Unidas para a Educação, a Ciência e a Cultura - UNESCO como patrimônio cultural. Em termos metodológicos, esta análise foi realizada com base em dados documentais e bibliográficos. Como resultados, foram apresentadas características para qualificar um centro histórico como um território turístico e criativo. Também observou-se níveis distintos de territórios criativos no contexto do turismo que podem (coexistirem na cidade investigada. Ao mesmo tempo, observou-se limitadas conexões justamente onde há expressões de criatividade e cultura. Portanto, esta investigação demonstrou que o processo de qualificação de territórios turísticos criativos é algo importante na contemporaneidade para a gestão do turismo e de destinos de forma sustentável.

  6. Miopatia do "core central": relato de um caso

    Directory of Open Access Journals (Sweden)

    Lineu Cesar Werneck

    1981-06-01

    Full Text Available É relatado o caso de um menino de 6 anos, branco, que apresentou hipotonia desde o nascimento, e retardo no desenvolvimento motor, que vem regredindo parcial e espontâneamente. A investigação laboratorial foi normal, com eletromiografia alterada. A biópsia muscular processada pela histoquímica, revelou importante predomínio de fibras do tipo I, ausência de atividade no centro das fibras musculares para as enzimas DPNH-diaforase e desidrogenase succínica, com atividade normal e até aumentada em algumas fibras durante as reações para as ATPases. São feitos breves comentários a respeito da patologia e patogenia, enfatizando a benignidade da doença.

  7. Niveles urinarios de angiotensina-(1-7) y angiotensina II en pacientes con estenosis aórtica de importante repercusión hemodinámica

    OpenAIRE

    López-de la Vega,César; Rosas-Peralta,Martín; Lomelí-Estrada,Catalina; Pastelín-Hernández,Gustavo; del Valle-Mondragón,Leonardo

    2011-01-01

    Objetivo:Reforzar el conocimiento sobre la fisiopatología de la estenosis aórtica. Métodos: Se compararon los niveles urinarios de angiotensina II y angiotensina-(1-7) entre dos muestras: a) 45 pacientes con estenosis aórtica de importante repercusión hemodinámica, sin hipertensión arterial sistémica y con funciones renal y sistólica ventricular izquierda normales; b) grupo de control con 21 voluntarios sin patología cardiovascular. Hipótesis nula: no habría diferencia entre los niveles urina...

  8. Características sociodemográficas e fatores importantes para a manutenção da saúde em mulheres

    Directory of Open Access Journals (Sweden)

    Márcia Cristina Sales

    2014-12-01

    Full Text Available Objetivo: Investigar fatores importantes para a manutenção da saúde e as características socioeconômicas e demográficas de mulheres usuárias de Unidades Básicas de Saúde. Métodos: Estudo observacional, transversal e analítico, realizado em 2011, envolvendo 204 mulheres assistidas em 16 unidades do município de Queimadas, Paraíba. Obtiveram-se informações referentes às características demográficas (local de moradia, cor da pele, idade e situação conjugal, socioeconômicas (nível de escolaridade e recebimento do Bolsa Família, e hábitos de vida (alimentação, tabagismo, consulta médica, sedentarismo, ingestão de bebidas alcoólicas, controle do peso e do estresse por meio de questionário, ao qual aplicou-se estatística descritiva e razão de prevalência. Resultados: As participantes apresentaram idade média de 28,22 anos (DP=6,49. A maioria residia na zona rural (n=126; 61,76%, declarou saber ler ou escrever (n=184; 90,2% e receber o benefício Bolsa Família (n=153; 75,0%. Os fatores mais importantes para a manutenção da saúde foram a alimentação saudável (n=126; 61,8%, o não tabagismo (n=21; 10,3% e a consulta médica regular (n=19; 9,3%. As variáveis socioeconômicas e demográficas não apresentaram associações estatísticas significativas com os fatores importantes para manutenção da saúde. Conclusão: A população estudada reconhece a alimentação saudável, o não tabagismo e as consultas médicas regulares como os fatores mais importantes para a manutenção da saúde.

  9. Comunicação Integrada de Marketing e Valor de Marca: um Estudo em Empresas de Tecnologia da Informação

    OpenAIRE

    Santana, Shirley Arruda

    2003-01-01

    A comunicação integrada de marketing (CIM) tornou-se um dos temas centrais entre acadêmicos e profissionais a partir da década de 90, sendo considerada um importante caminho para facilitar e para manter fortes estruturas de memória de marca através do tempo, podendo harmonizar e reforçar as impressões desta junto ao públicoalvo. As organizações ainda não descobriram de um modo geral o poder da comunicação, que é capaz de renovar o ambiente de marketing, facilitar as relações e ...

  10. Levantamento das condições de trabalho em um serviço de equoterapia segundo a visão macroergonômica

    OpenAIRE

    Luís Cláudio Martins Chiaramonte

    2004-01-01

    Este estudo tem como objetivo investigar as condições de trabalho de um serviço de equoterapia. A metodologia utilizada foi a ferramenta Design Macroergonômico (DM) proposto por Fogliatto e Guimarães (1999), tendo sido avaliadas as demandas ergonômicas dos dez trabalhadores de um Centro de Equoterapia da Cidade de Caxias do Sul. Os resultados indicam que as exigências físicas do trabalho não são um problema e que os trabalhadores não sentem dor como era esperado. As demandas importantes dizem...

  11. Distribution of enrofloxacin in intestinal tissue and contents of healthy pigs after oral and intramuscular administrations

    DEFF Research Database (Denmark)

    Wiuff, C.; Lykkesfeldt, J.; Aarestrup, Frank Møller

    2002-01-01

    The concentration of enrofloxacin in plasma, intestinal tissue, lymph nodes and intestinal contents was investigated in healthy pigs after oral (p.o.) and intramuscular (i.m.) administration of a single dose of 2.5 mg/kg bw. Tissue and content samples were collected from jejunum, ileum, caecum...... administration, and maximum concentrations in tissue and plasma were determined later than after i.m. administration. No difference between route of administration was observed in the intestinal content. Enrofloxacin concentrations in faeces during a 5-day dosing regimen with i.m. and p.o. administration were....... On the basis of these results it was concluded that in order to ensure an immediate high concentration of enrofloxacin, and thereby avoid an initial selection for resistant mutants, the intramuscular route seems to be preferable to the oral route....

  12. Pharmacokinetics of ketoprofen in the green iguana (Iguana iguana) following single intravenous and intramuscular injections.

    Science.gov (United States)

    Tuttle, Allison D; Papich, Mark; Lewbart, Gregory A; Christian, Shane; Gunkel, Conny; Harms, Craig A

    2006-12-01

    The nonsteroidal antiinflammatory drug ketoprofen (KTP) is a commonly used antiinflammatory and analgesic agent in reptile medicine, but no studies documenting its pharmacokinetics in this species have been published. Ketoprofen was administered as a racemic mixture to green iguanas (Iguana iguana) intravenously (i.v.) and intramuscularly (i.m.) at 2 mg/kg. Pharmacokinetic analyses were performed and indicated that ketoprofen in iguanas administered by the intravenous route has a classical two-compartmental distribution pattern, a slow clearance (67 ml/ kg/hr) and a long terminal half-life (31 hr) compared to ketoprofen studies reported in mammals. When delivered by the intramuscular route, bioavailability was 78%. These data indicate the daily dosing that is generally recommended for reptile patients, as an extrapolation from mammalian data, may be more frequent than necessary.

  13. Sequential decoding of intramuscular EMG signals via estimation of a Markov model.

    Science.gov (United States)

    Monsifrot, Jonathan; Le Carpentier, Eric; Aoustin, Yannick; Farina, Dario

    2014-09-01

    This paper addresses the sequential decoding of intramuscular single-channel electromyographic (EMG) signals to extract the activity of individual motor neurons. A hidden Markov model is derived from the physiological generation of the EMG signal. The EMG signal is described as a sum of several action potentials (wavelet) trains, embedded in noise. For each train, the time interval between wavelets is modeled by a process that parameters are linked to the muscular activity. The parameters of this process are estimated sequentially by a Bayes filter, along with the firing instants. The method was tested on some simulated signals and an experimental one, from which the rates of detection and classification of action potentials were above 95% with respect to the reference decomposition. The method works sequentially in time, and is the first to address the problem of intramuscular EMG decomposition online. It has potential applications for man-machine interfacing based on motor neuron activities.

  14. First intramuscular administration in the U.S. space program. [of motion sickness drugs

    Science.gov (United States)

    Bagian, James P.

    1991-01-01

    In the past, the only kind of medicines used for symptomatic treatment of space motion sickness (SMS) in space had been oral, transdermal, or suppositories. This paper describes the effect of the first intramuscular (IM) administration of Phenergan (50-mg in single dose) on SMS in one subject who exhibited grade-3 symptoms and signs which persisted unabated throughout the first and the second flight days aboard the Space Shuttle. Thirty minutes after the injection, the subject had completely recovered. His symptoms were gone, his appetite was back, and he had no recurrences for the remainder of the flight. Since that experiment, intramuscular injections have been given nine more times on subsequent flights, with similar results.

  15. Influence of conjugated linoleic acid (CLA on intramuscular fatty acid composition in rabbit

    Directory of Open Access Journals (Sweden)

    C. Corino

    2010-01-01

    Full Text Available The impact of feeding CLA has been thoroughly investigated in pigs, and Thiel- Cooper et al. (2001, Ostrowska et al. (2003, Lo Fiego et al. (2004, found that CLA modifies lipid fatty acid profile, negatively affecting some nutritional lipid indexes. So far,much less attention has been paid to rabbits. Recently, Corino et al. (2003 have shown that supplementing rabbit diets with CLA has limited effect on the chemical composition of meat and at a high slaughter weight reduces intramuscular fat content. The present research has been carried out to evaluate the effect of dietary CLA supplementation on cis-9, trans-11 and trans-10,cis-12- C18:2 isomers content, and on fatty acid composition of rabbit intramuscular lipids.

  16. Concurrent emphysematous pyelonephritis and thigh necrotizing fasciitis after intramuscular administration of diclofenac

    Directory of Open Access Journals (Sweden)

    Fateme Shamekhi Amiri

    2014-01-01

    Full Text Available Necrotizing fasciitis (NF is a rapidly progressive, life-threatening soft tissue infec-tion. NF may result from any injury to the skin or from hematogenous spread. However, con-current emphysematous pyelonephritis and necrotizing fasciitis of the left thigh has not been reported. We report a case of emphysematous pyelonephritis and necrotizing fasciitis of the left thigh after intramuscular administration of diclofenac that improved with aggressive management including broad-spectrum antibiotics, nephrectomy and surgical intervention.

  17. Giant intramuscular lipoma of the tongue: a case report and literature review

    OpenAIRE

    Colella, Giuseppe; Biondi, Paolo; Caltabiano, Rosario; Vecchio, Giada Maria; Amico, Paolo; Magro, Gaetano

    2009-01-01

    We herein report a rare case of giant intramuscular lipoma of the tongue. A 75-year-old Italian male presented at our department with a large tumor at the tip of the tongue that had been present for over 30 years. Clinical examination revealed a yellowish lesion, measuring 10 cm in maximum diameter, protruding from lingual surface. Histological examination showed an unencapsulated lipomatous tumor composed of mature adipocytes, uniform in size and shape, diffusely infiltrating striated muscle...

  18. Pharmacokinetics of diclofenac in pigs after intramuscular administration of a single dose

    OpenAIRE

    Pejčić Zorica; Pokrajac Milena; Jezdimirović Milanka

    2006-01-01

    The pharmacokinetics of diclofenac was studied in 10 clinically normal male Yorkshire pigs, following intramuscular (i.m) administration of a single dose of diclofenac-sodium (2.5 mg/kg body weight). Diclofenac serum concentrations were determined by high pressure- liquid-chromatography (HPLC), with UV detection (226 nm). Following i.m. administration all individual diclofenac serum levels best fitted the one-compartment open model for extravascular administration. The maximal diclofenac seru...

  19. Intramuscular Distribution of the Abducens Nerve in the Lateral Rectus Muscle for the Management of Strabismus.

    Science.gov (United States)

    Shin, Hyun Jin; Lee, Shin-Hyo; Shin, Kang-Jae; Koh, Ki-Seok; Song, Wu-Chul

    2018-06-01

    To elucidate the intramuscular distribution and branching patterns of the abducens nerve in the lateral rectus (LR) muscle so as to provide anatomical confirmation of the presence of compartmentalization, including for use in clinical applications such as botulinum toxin injections. Thirty whole-mount human cadaver specimens were dissected and then Sihler's stain was applied. The basic dimensions of the LR and its intramuscular nerve distribution were investigated. The distances from the muscle insertion to the point at which the abducens nerve enters the LR and to the terminal nerve plexus were also measured. The LR was 46.0 mm long. The abducens nerve enters the muscle on the posterior one-third of the LR and then typically divides into a few branches (average of 1.8). This supports a segregated abducens nerve selectively innervating compartments of the LR. The intramuscular nerve distribution showed a Y-shaped ramification with root-like arborization. The intramuscular nerve course finished around the middle of the LR (24.8 mm posterior to the insertion point) to form the terminal nerve plexus. This region should be considered the optimal target site for botulinum toxin injections. We have also identified the presence of an overlapping zone and communicating nerve branches between the neighboring LR compartments. Sihler's staining is a useful technique for visualizing the entire nerve network of the LR. Improving the knowledge of the nerve distribution patterns is important not only for researchers but also clinicians to understand the functions of the LR and the diverse pathophysiology of strabismus.

  20. Vaccine-induced myositis with intramuscular sterile abscess formation: MRI and ultrasound findings

    Energy Technology Data Exchange (ETDEWEB)

    Polat, Ahmet Veysel; Bekci, Tumay; Selcuk, Mustafa Bekir [Ondokuz Mayis University, Department of Radiology, Faculty of Medicine, Samsun (Turkey); Dabak, Nevzat [Ondokuz Mayis University, Department of Orthopaedics and Traumatology, Faculty of Medicine, Samsun (Turkey); Ulu, Esra Meltem Kayahan [Samsun Medical Park Hospital, Department of Radiology, Samsun (Turkey)

    2015-12-15

    Although limb swelling is a well-known complication of vaccination, its rarity and wide band of differential diagnosis of limb swelling make it a diagnostic challenge. In this case report, we describe three cases of vaccine-induced myositis with intramuscular sterile abscess formation in patients with limb swelling and their magnetic resonance imaging and ultrasonography findings. Both radiologists and clinicians should be familiar with this rare entity, its clinical and imaging spectrum, and follow-up strategies. (orig.)

  1. Vaccine-induced myositis with intramuscular sterile abscess formation: MRI and ultrasound findings

    International Nuclear Information System (INIS)

    Polat, Ahmet Veysel; Bekci, Tumay; Selcuk, Mustafa Bekir; Dabak, Nevzat; Ulu, Esra Meltem Kayahan

    2015-01-01

    Although limb swelling is a well-known complication of vaccination, its rarity and wide band of differential diagnosis of limb swelling make it a diagnostic challenge. In this case report, we describe three cases of vaccine-induced myositis with intramuscular sterile abscess formation in patients with limb swelling and their magnetic resonance imaging and ultrasonography findings. Both radiologists and clinicians should be familiar with this rare entity, its clinical and imaging spectrum, and follow-up strategies. (orig.)

  2. Sustained-release progesterone nanosuspension following intramuscular injection in ovariectomized rats

    OpenAIRE

    Kharshoum, rasha

    2010-01-01

    Heba F SalemFaculty of Pharmacy, Beni-Suef University, Beni-Suef, EgyptAbstract: The production of an intramuscular (IM) injection of natural progesterone would provide a safer solution than using semi synthetic progesterone. However, disadvantages such as low solubility and a short half life prevent the use of natural progesterone. In this study, we formulated a sustained release form of natural progesterone to be given as IM injection. A progesterone nanosuspension (PNS) was first developed...

  3. Nitric oxide nanoparticles: Pre-clinical utility as a therapeutic for intramuscular abscesses

    OpenAIRE

    Schairer, David O.; Martinez, Luis R.; Blecher, Karin; Chouake, Jason S.; Nacharaju, Parimala; Gialanella, Philip; Friedman, Joel M.; Nosanchuk, Joshua D.; Friedman, Adam J.

    2012-01-01

    Nitric oxide (NO) is a critical component of host defense against invading pathogens; however, its therapeutic utility is limited due to a lack of practical delivery systems. Recently, a NO-releasing nanoparticulate platform (NO-np) was shown to have in vitro broad-spectrum antimicrobial activity and in vivo pre-clinical efficacy in a dermal abscess model. To extend these findings, both topical (TP) and intralesional (IL) NO-np administration was evaluated in a MRSA intramuscular murine absce...

  4. Serial MR Imaging of Intramuscular Hematoma: Experimental Study in a Rat Model with the Pathologic Correlation

    Science.gov (United States)

    Lee, Yeon Soo; Kwon, Soon Tae; Kim, Jong Ok

    2011-01-01

    Objective We wanted to demonstrate the temporal changes of the magnetic resonance imaging (MRI) findings in experimentally-induced intramuscular hematomas in rats and to correlate these data with the concurrent pathologic observations. Materials and Methods Intramuscular hematoma was induced in 30 rats. The MR images were obtained at 1, 4, 7 and 10 days and at 2, 3, 4, 6 and 8 weeks after muscle injury. The characteristic serial MRI findings were evaluated and the relative signal intensities were calculated. Pathologic specimens were obtained at each time point. Results On the T1-weighted imaging (T1WI), the intramuscular hematomas exhibited isointensity compared to that of muscle or the development of a high signal intensity (SI) rim on day one after injury. The high SI persisted until eight weeks after injury. On the T2-weighted imaging (T2WI), the hematomas showed high SI or centrally low SI on day one after injury, and mainly high SI after four days. A dark signal rim was apparent after seven days, which was indicative of hemosiderin on the pathology. The gradient echo (GRE) imaging yielded dark signal intensities at all stages. Conclusion Unlike brain hematomas, experimentally-induced intramuscular hematomas show increased SI on both the T1WI and T2WI from the acute stage onward, and this is pathologically correlated with a rich blood supply and rapid healing response to injury in the muscle. On the T2WI and GRE imaging, high SI with a peripheral dark signal rim is apparent from seven days to the chronic stage. PMID:21228942

  5. Acute selenium toxicity in lambs following intramuscular injection of sodium selenite

    Energy Technology Data Exchange (ETDEWEB)

    Caravaggi, C; Clark, F L; Jackson, A R.B.

    1970-01-01

    The LD50 in lambs from a farm where selenium deficiency has not been recorded was found to be 45..mu..g. of Se/kg. body weight when sodium selenite was administered as a single intramuscular injection. Marked pulmonary congestion and oedema were constantly present with degenerative changes in liver and kidney. A similarity was noted between the autopsy findings of acute selenosis and those described for enterotoxaemia. 13 references, 4 figures.

  6. Serial MR Imaging of Intramuscular Hematoma: Experimental Study in a Rat Model with the Pathologic Correlation

    International Nuclear Information System (INIS)

    Lee, Yeon Soo; Kim, Jong Ok; Choi, Eun Seok; Kwon, Soon Tae

    2011-01-01

    We wanted to demonstrate the temporal changes of the magnetic resonance imaging (MRI) findings in experimentally-induced intramuscular hematomas in rats and to correlate these data with the concurrent pathologic observations. Intramuscular hematoma was induced in 30 rats. The MR images were obtained at 1, 4, 7 and 10 days and at 2, 3, 4, 6 and 8 weeks after muscle injury. The characteristic serial MRI findings were evaluated and the relative signal intensities were calculated. Pathologic specimens were obtained at each time point. On the T1-weighted imaging (T1WI), the intramuscular hematomas exhibited isointensity compared to that of muscle or the development of a high signal intensity (SI) rim on day one after injury. The high SI persisted until eight weeks after injury. On the T2-weighted imaging (T2WI), the hematomas showed high SI or centrally low SI on day one after injury, and mainly high SI after four days. A dark signal rim was apparent after seven days, which was indicative of hemosiderin on the pathology. The gradient echo (GRE) imaging yielded dark signal intensities at all stages. Unlike brain hematomas, experimentally-induced intramuscular hematomas show increased SI on both the T1WI and T2WI from the acute stage onward, and this is pathologically correlated with a rich blood supply and rapid healing response to injury in the muscle. On the T2WI and GRE imaging, high SI with a peripheral dark signal rim is apparent from seven days to the chronic stage

  7. Efficacy and safety of vitamin D3 B.O.N intramuscular injection in Korean adults with vitamin D deficiency

    Directory of Open Access Journals (Sweden)

    Han Seok Choi

    2016-12-01

    Conclusion: Intramuscular injection of vitamin D3 200,000 IU was superior to placebo in terms of its impact on serum 25(OHD concentrations, and is considered to be safe and effective in Korean adults with vitamin D deficiency.

  8. Um modelo para analisar o problema de filas em caixas de supermercados: um estudo de caso

    Directory of Open Access Journals (Sweden)

    Reinaldo Morabito

    2000-06-01

    Full Text Available Neste estudo aplicamos teoria de filas para analisar o problema de congestão em caixas de supermercados. Estamos particularmente interessados em modelar o tempo médio de espera em fila, aqui entendido como uma componente importante do nível de serviço ao consumidor, em função da capacidade do sistema (i.e., o número de caixas num dado período de tempo. Três modelos são explorados: (i representar o sistema por meio de um simples modelo M/M/m de fila única, onde m é o número de caixas, (ii representar o sistema por meio de m modelos M/M/1 paralelos e independentes, e (iii representar o sistema por meio de um modelo Markoviano mais geral, onde os dois modelos anteriores podem ser vistos como casos particulares. Para avaliar o desempenho destes modelos, realizamos um estudo de caso num dos supermercados da rede Jaú-Serve, localizado no interior de São Paulo. Os resultados mostraram que o terceiro modelo pode resultar numa boa aproximação para o problema, ao contrário dos dois primeiros.In this study we applied queueing theory to analyze the problem of congestion in supermarket check-outs. We are particularly concerned with modeling the mean user waiting time in the queue, viewed as an important component of the user service, as a function of the capacity of the system (i.e., the number of cashiers in a given time period. Three models are explored: (i to represent the system by means of a simple M/M/m queueing model, where m is the number of cashiers, (ii to represent the system by means of m parallel and independent M/M/1 queueing models, and (iii to represent the system by means of a more generic Markovian model, where the former models can be viewed as particular cases. In order to evaluate the performance of the models, we developed a case study in one of the supermarkets of Jaú-Serve chain located in São Paulo State. The results showed that the third model can yield a good approximation for the problem, different from the

  9. Vivencias emocionais de mulheres submetidas a cirurgia bariatrica no Hospital de Clinicas da Unicamp : um estudo clinico-qualitativo

    OpenAIRE

    Ronis Magdaleno Junior

    2009-01-01

    Resumo: Este estudo teve por objetivo compreender as vivências emocionais de mulheres obesas mórbidas submetidas à cirurgia bariátrica. A obesidade tornou-se, globalmente, um grave problema de saúde pública e, em função disto, tem crescido de modo expressivo o número de cirurgias bariátricas como opção de tratamento para a obesidade mórbida. Contudo, é um procedimento que implica em importantes modificações físicas e psicossociais para o paciente. Metodologia: Aplicamos o Método Clínico Quali...

  10. Intramuscular versus intravenous prophylactic oxytocin for postpartum hemorrhage after vaginal delivery: a randomized controlled study.

    Science.gov (United States)

    Dagdeviren, Hediye; Cengiz, Huseyin; Heydarova, Ulkar; Caypinar, Sema Suzen; Kanawati, Ammar; Guven, Ender; Ekin, Murat

    2016-11-01

    Prevention of postpartum haemorrhage (PPH) is essential in the pursuit of improved health care for women. Oxytocin, the most commonly used uterotonic agent to prevent PPH, has no established the route of administration. In this study we aimed to compare whether the mode of oxytocin administration, i.e., intravenous and intramuscular administration, has an effect on the potential benefits and side effects. A total of 256 women were randomised into two groups: intramuscular group (128) or intravenous group (128). Estimated blood loss during the third stage of labour was similar between the two groups (p = 0.572). Further there were no statistically significant difference was noted between the two groups in terms of the mean duration of labor, duration of the third stage of labor, manual removal of the placenta, need for instrumental delivery, need for blood transfusion, PPH ≥500 mL, PPH ≥1000 mL, or length of hospital stay. Using oxytocin by intravenous and intramuscular route has a similar efficacy and adverse effects.

  11. Pharmacokinetics and -dynamics of intramuscular and intranasal naloxone: an explorative study in healthy volunteers.

    Science.gov (United States)

    Skulberg, Arne Kristian; Tylleskar, Ida; Nilsen, Turid; Skarra, Sissel; Salvesen, Øyvind; Sand, Trond; Loftsson, Thorsteinn; Dale, Ola

    2018-03-22

    This study aimed to develop a model for pharmacodynamic and pharmacokinetic studies of naloxone antagonism under steady-state opioid agonism and to compare a high-concentration/low-volume intranasal naloxone formulation 8 mg/ml to intramuscular 0.8 mg. Two-way crossover in 12 healthy volunteers receiving naloxone while receiving remifentanil by a target-controlled infusion for 102 min. The group were subdivided into three different doses of remifentanil. Blood samples for serum naloxone concentrations, pupillometry and heat pain threshold were measured. The relative bioavailability of intranasal to intramuscular naloxone was 0.75. Pupillometry showed difference in antagonism; the effect was significant in the data set as a whole (p < 0.001) and in all three subgroups (p < 0.02-p < 0.001). Heat pain threshold showed no statistical difference. A target-controlled infusion of remifentanil provides good conditions for studying the pharmacodynamics of naloxone, and pupillometry was a better modality than heat pain threshold. Intranasal naloxone 0.8 mg is inferior for a similar dose intramuscular. Our design may help to bridge the gap between studies in healthy volunteers and the patient population in need of naloxone for opioid overdose. clinicaltrials.gov : NCT02307721.

  12. Association between FASN gene polymorphisms ultrasound carcass traits and intramuscular fat in Qinchuan cattle.

    Science.gov (United States)

    Raza, Sayed Haidar Abbas; Gui, Linsheng; Khan, Rajwali; Schreurs, Nicola M; Xiaoyu, Wang; Wu, Sen; Mei, Chugang; Wang, Li; Ma, Xueyao; Wei, Dawei; Guo, Hongfang; Zhang, Song; Wang, Xingping; Kaleri, Hubdar Ali; Zan, Linsen

    2018-03-01

    Fatty acid synthase (FASN) is an enzyme involved with fat deposition and fatty acid composition in cattle. This study was conducted to detect single nucleotide polymorphisms (SNPs) of the FASN gene and explore their relationships with ultrasound carcass traits in order to assess the potential use of the FASN gene for the breeding selection of Qinchuan cattle for desirable carcass traits. The frequencies of SNP g.12740C>T, g.13192T>C and g.13232C>T were identified in 525 individual Qinchuan cattle which were also assessed for backfat depth, eye muscle area and intramuscular fat by ultrasound. According to the PIC values, g.13192T>C possessed an intermediate polymorphism (0.25T, g.12740C>T possessed low polymorphism (PICC were in Hardy-Weinberg disequilibrium (c2C was associated with a greater eye muscle area and the TT genotype at g.13232C>T was associated with greater intramuscular fat. When these genotypes were combined there was no difference in eye muscle area and intramuscular fat between the diplotypes. The H 2 H 2 diplotype was associated with carcass traits that are likely to provide economic advantage in Qinchuan cattle. Variations in the FASN genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. Efficacy and Tolerability of Intramuscular Dexketoprofen in Postoperative Pain Management following Hernia Repair Surgery

    Directory of Open Access Journals (Sweden)

    P. T. Jamdade

    2011-01-01

    Full Text Available Objective. To evaluate the safety and efficacy of intramuscular dexketoprofen for postoperative pain in patients undergoing hernia surgery. Methodology. Total 202 patients received single intramuscular injection of dexketoprofen 50 mg or diclofenac 50 mg postoperatively. The pain intensity (PI was self-evaluated by patients on VAS at baseline 1, 2, 4, 6, and 8 hours. The efficacy parameters were number of responders, difference in PI (PID at 8 hours, sum of analogue of pain intensity differences (SAPID, and onset and duration of analgesia. Tolerability assessment was done by global evaluation and adverse events in each group. Results. Dexketoprofen showed superior efficacy in terms of number of responders (P=.007, PID at 8 hours (P=.02, and SAPID 0–8 hours (P<.0001. It also showed faster onset of action (42 minutes and longer duration of action (6.5 hours. The adverse events were comparable in both groups. Conclusion. Single dose of dexketoprofen trometamol 50 mg given intramuscularly provided faster, better, and longer duration of analgesia in postoperative patients of hernia repair surgery than diclofenac 50 mg, with comparable safety.

  14. Intramuscular manifestation of non-Hodgkin lymphoma and myeloma: Prevalence, clinical signs, and computed tomography features

    Energy Technology Data Exchange (ETDEWEB)

    Surov, Alexey; Spielmann, Rolf-Peter; Behrmann, Curd (Dept. of Radiology, Martin Luther Univ., Halle-Wittenberg (Germany)), e-mail: alex.surow@medizin.uni-halle.de; Holzhausen, Hans-Juergen (Dept. of Hematology/Oncology, Martin Luther Univ., Halle-Wittenberg (Germany)); Arnold, Dirk (Dept. of Pathology, Martin Luther Univ., Halle-Wittenberg (Germany)); Schmidt, Joerg (Dept. of Medical Statistics and Controlling, Martin Luther Univ., Halle-Wittenberg (Germany))

    2010-01-15

    Background: Intramuscular manifestations of malignant immuno proliferative diseases (IMMID) are very rare. Purpose: To determine the prevalence and the clinical features of IMMID in a large series of patients, and to analyze their radiological appearances. Material and Methods: Between 1997 and 2007, 20 patients with IMMID (non-Hodgkin lymphoma [NHL], n=14, and myeloma, n=6) were identified. All patients underwent computed tomography (CT). In five cases, magnetic resonance imaging (MRI) was additionally performed. Results: Clinically, 16 patients presented with local pain and soft-tissue swelling. In four patients, IMMID was found incidentally. The most common site was the erector spinae muscle, followed by the iliopsoas and pelvic muscles. In 13 cases of IMMID, diffuse mass-forming muscle infiltration was found. Focal intramuscular masses were identified in seven cases. Conclusion: NHL mostly manifests as diffuse muscle enlargement, whereas myelomas form focal intramuscular masses. Nevertheless, CT and MR appearances are nonspecific and can be misinterpreted as muscle sarcoma or inflammatory disease. Although rare, muscle involvement should be considered in the differential diagnosis of muscle disorders in patients with non-Hodgkin lymphoma and myeloma

  15. Kinesio® Tape Barrier Does Not Inhibit Intramuscular Cooling During Cryotherapy.

    Science.gov (United States)

    Lyman, Katie J; McCrone, Michael; Hanson, Thomas A; Mellinger, Christopher D; Gange, Kara

    2018-05-29

    Allied health care professionals commonly apply cryotherapy as treatment for acute musculoskeletal trauma and the associated symptoms. Understanding the impact of a tape barrier on intramuscular temperature can assist in determining treatment duration for effective cryotherapy. To determine whether Kinesio® Tape acts as a barrier that affects intramuscular temperature during cryotherapy application. A repeated-measures, counterbalanced design in which the independent variable was tape application and the dependent variable was muscle temperature as measured by thermocouples placed 1 cm beneath the adipose layer. Additional covariates for robustness were BMI and adipose thickness. University research laboratory. 19 male college students with no contraindications to cryotherapy, no known sensitivity to Kinesio® Tape, and no reported quadriceps injury within the past six months. Topical cryotherapy: crushed-ice bags of 1 kg and 0.5 kg. Intramuscular temperature. The tape barrier had no statistically significant effect on muscle temperature. The pattern of temperature change was indistinguishable between participants with and without tape application. Findings suggest health care professionals can combine cryotherapy with a Kinesio® Tape application without any need for adjustments to cryotherapy duration.

  16. Extracellular Matrix and Growth Factors Improve the Efficacy of Intramuscular Islet Transplantation.

    Directory of Open Access Journals (Sweden)

    Haruyuki Tsuchiya

    Full Text Available The efficacy of intramuscular islet transplantation is poor despite being technically simple, safe, and associated with reduced rates of severe complications. We evaluated the efficacy of combined treatment with extracellular matrix (ECM and growth factors in intramuscular islet transplantation.Male BALB/C mice were used for the in vitro and transplantation studies. The following three groups were evaluated: islets without treatment (islets-only group, islets embedded in ECM with growth factors (Matrigel group, and islets embedded in ECM without growth factors [growth factor-reduced (GFR Matrigel group]. The viability and insulin-releasing function of islets cultured for 96 h were significantly improved in Matrigel and GFR Matrigel groups compared with the islets-only group.Blood glucose and serum insulin levels immediately following transplantation were significantly improved in the Matrigel and GFR Matrigel groups and remained significantly improved in the Matrigel group at postoperative day (POD 28. On histological examination, significantly decreased numbers of TdT-mediated deoxyuridine triphosphate-biotin nick end labeling-positive islet cells and significantly increased numbers of Ki67-positive cells were observed in the Matrigel and GFR Matrigel groups at POD 3. Peri-islet revascularization was most prominent in the Matrigel group at POD 14.The efficacy of intramuscular islet transplantation was improved by combination treatment with ECM and growth factors through the inhibition of apoptosis, increased proliferation of islet cells, and promotion of revascularization.

  17. Intramuscular injection of malignant hyperthermia trigger agents induces hypermetabolism in susceptible and nonsusceptible individuals.

    Science.gov (United States)

    Metterlein, Thomas; Schuster, Frank; Kranke, Peter; Roewer, Norbert; Anetseder, Martin

    2010-01-01

    A new minimally invasive metabolic test for the diagnosis of susceptibility for malignant hyperthermia measuring intramuscular p(CO(2)) and lactate following local application of caffeine and halothane in humans was recently proposed. The present study tested the hypothesis that a more simplified test protocol allows a differentiation between malignant hyperthermia susceptible (MHS) and malignant hyperthermia nonsusceptible (MHN) and control individuals. With approval of the local ethics committee and informed consent, microdialysis and p(CO(2)) probes with attached microtubing were placed into the lateral vastus muscle of six MHS, seven MHN and seven control individuals. Following equilibration, boluses of 500 microl caffeine 80 mmol l(-1) and halothane 10 vol% dissolved in soybean oil were injected locally. p(CO(2)) and lactate were measured spectrophotometrically. The maximal rate of p(CO(2)) increase was significantly higher in MHS than in MHN and control individuals following application of halothane and caffeine, respectively. Intramuscular caffeine injection leads to a significantly higher increase of local lactate levels in MHS than in MHN and control individuals, whereas halothane increased local lactate levels in all investigated groups. Haemodynamic and systemic metabolic parameters did not differ between the investigated groups. Local caffeine and halothane injection increased intramuscular metabolism in MHS individuals significantly more than in the two other groups. In contrast to previous investigations, direct injection of the concentrations of halothane described here increased lactate and p(CO(2)) even in MHN skeletal muscle.

  18. Extracellular Matrix and Growth Factors Improve the Efficacy of Intramuscular Islet Transplantation.

    Science.gov (United States)

    Tsuchiya, Haruyuki; Sakata, Naoaki; Yoshimatsu, Gumpei; Fukase, Masahiko; Aoki, Takeshi; Ishida, Masaharu; Katayose, Yu; Egawa, Shinichi; Unno, Michiaki

    2015-01-01

    The efficacy of intramuscular islet transplantation is poor despite being technically simple, safe, and associated with reduced rates of severe complications. We evaluated the efficacy of combined treatment with extracellular matrix (ECM) and growth factors in intramuscular islet transplantation. Male BALB/C mice were used for the in vitro and transplantation studies. The following three groups were evaluated: islets without treatment (islets-only group), islets embedded in ECM with growth factors (Matrigel group), and islets embedded in ECM without growth factors [growth factor-reduced (GFR) Matrigel group]. The viability and insulin-releasing function of islets cultured for 96 h were significantly improved in Matrigel and GFR Matrigel groups compared with the islets-only group. Blood glucose and serum insulin levels immediately following transplantation were significantly improved in the Matrigel and GFR Matrigel groups and remained significantly improved in the Matrigel group at postoperative day (POD) 28. On histological examination, significantly decreased numbers of TdT-mediated deoxyuridine triphosphate-biotin nick end labeling-positive islet cells and significantly increased numbers of Ki67-positive cells were observed in the Matrigel and GFR Matrigel groups at POD 3. Peri-islet revascularization was most prominent in the Matrigel group at POD 14. The efficacy of intramuscular islet transplantation was improved by combination treatment with ECM and growth factors through the inhibition of apoptosis, increased proliferation of islet cells, and promotion of revascularization.

  19. Sodium Nitrite and Sodium Thiosulfate Are Effective Against Acute Cyanide Poisoning When Administered by Intramuscular Injection.

    Science.gov (United States)

    Bebarta, Vikhyat S; Brittain, Matthew; Chan, Adriano; Garrett, Norma; Yoon, David; Burney, Tanya; Mukai, David; Babin, Michael; Pilz, Renate B; Mahon, Sari B; Brenner, Matthew; Boss, Gerry R

    2017-06-01

    The 2 antidotes for acute cyanide poisoning in the United States must be administered by intravenous injection. In the out-of-hospital setting, intravenous injection is not practical, particularly for mass casualties, and intramuscular injection would be preferred. The purpose of this study is to determine whether sodium nitrite and sodium thiosulfate are effective cyanide antidotes when administered by intramuscular injection. We used a randomized, nonblinded, parallel-group study design in 3 mammalian models: cyanide gas inhalation in mice, with treatment postexposure; intravenous sodium cyanide infusion in rabbits, with severe hypotension as the trigger for treatment; and intravenous potassium cyanide infusion in pigs, with apnea as the trigger for treatment. The drugs were administered by intramuscular injection, and all 3 models were lethal in the absence of therapy. We found that sodium nitrite and sodium thiosulfate individually rescued 100% of the mice, and that the combination of the 2 drugs rescued 73% of the rabbits and 80% of the pigs. In all 3 species, survival in treated animals was significantly better than in control animals (log rank test, Pcyanide poisoning in 3 clinically relevant animal models of out-of-hospital emergency care. Copyright © 2016 American College of Emergency Physicians. Published by Elsevier Inc. All rights reserved.

  20. Assessing Anticalcification Treatments in Bioprosthetic Tissue by Using the New Zealand Rabbit Intramuscular Model

    Science.gov (United States)

    Wright, Gregory A; Faught, Joelle M; Olin, Jane M

    2009-01-01

    The objective of this work was to demonstrate that the New Zealand White (NZW) rabbit intramuscular model can be used for detecting calcification in bioprosthetic tissue and to compare the calcification in the rabbit to that of native human valves. The rabbit model was compared with the commonly used Sprague–Dawley rat subcutaneous model. Eighteen rabbits and 18 rats were used to assess calcification in bioprosthetic tissue over time (7, 14, 30, and 90 d). The explanted rabbit and rat tissue discs were measured for calcium by using atomic absorption and Raman spectroscopy. Calcium deposits on the human valve explants were assessed by using Raman spectroscopy. The results showed that the NZW rabbit model is robust for detecting calcification in a shorter duration (14 d), with less infection complications, more space to implant tissue groups (thereby reducing animal use numbers), and a more metabolically and mechanically dynamic environment than the rat subcutaneous model . The human explanted valves and rabbit explanted tissue both showed Raman peaks at 960 cm−1 which is representative of hydroxyapatite. Hydroxyapatite is the final calcium and phosphate species in the calcification of bioprosthetic heart valves and rabbit intramuscular implants. The NZW rabbit intramuscular model is an effective model for assessing calcification in bioprosthetic tissue. PMID:19619417

  1. Efficacy of Doramectin Via Intramuscular Injection in Gastrointestinal Nematodes in Horses

    Directory of Open Access Journals (Sweden)

    Yonairo Manuel Herrera Benavides

    2015-05-01

    Full Text Available This research aimed to test the effectiveness of doramectin by intramuscular administration against nematodes of horses, as it is evacuated, observed in the reduction in egg counts per gram of feces (epg. To this end, six donkeys and ten mestizo horses of different sexes and ages were used, all naturally infected with gastrointestinal nematodes. Animals were randomly divided into two groups: 1 (control, three donkeys and four horses that didn’t receive anthelmintic treatment; and 2 (treated, three donkeys and six horses treated with doramectin at a dose of 0.2 mg/kg by intramuscular administration, single dose, applied on the neck. At days 5, 12, 16, 24, 34, 41, 47, 56, 60 and 140 post-treatment all animals were subjected to stool tests, allowing to define epg values by McMaster technique. The results determined that doramectin by intramuscular administration was highly effective in controlling nematodes in field conditions and in animals subjected to continual reinfestation.

  2. Irreversible muscle damage in bodybuilding due to long-term intramuscular oil injection.

    Science.gov (United States)

    Banke, I J; Prodinger, P M; Waldt, S; Weirich, G; Holzapfel, B M; Gradinger, R; Rechl, H

    2012-10-01

    Intramuscular oil injections generating slowly degrading oil-based depots represent a controversial subject in bodybuilding and fitness. However they seem to be commonly reported in a large number of non-medical reports, movies and application protocols for 'site-injections'. Surprisingly the impact of long-term (ab)use on the musculature as well as potential side-effects compromising health and sports ability are lacking in the medical literature. We present the case of a 40 year old male semi-professional bodybuilder with systemic infection and painful reddened swellings of the right upper arm forcing him to discontinue weightlifting. Over the last 8 years he daily self-injected sterilized sesame seed oil at numerous intramuscular locations for the purpose of massive muscle building. Whole body MRI showed more than 100 intramuscular rather than subcutaneous oil cysts and loss of normal muscle anatomy. 2-step septic surgery of the right upper arm revealed pus-filled cystic scar tissue with the near-complete absence of normal muscle. MRI 1 year later revealed the absence of relevant muscle regeneration. Persistent pain and inability to perform normal weight training were evident for at least 3 years post-surgery. This alarming finding indicating irreversible muscle mutilation may hopefully discourage people interested in bodybuilding and fitness from oil-injections. The impact of such chronic tissue stress on other diseases like malignancy remains to be determined. © Georg Thieme Verlag KG Stuttgart · New York.

  3. Leg amputation following intramuscular injection of iron dextran in a 32 year old woman

    Directory of Open Access Journals (Sweden)

    Gloria Shalviri

    2015-10-01

    Full Text Available To inform healthcare professionals of a rare serious reaction leading to leg amputation following intramuscular injection of iron dextran and report comments for preventing such reactions.A case of leg amputation following intramuscular injection of iron dextran reported to Iranian Pharmacovigilance Center was reviewed. Patient and reaction data was collected by assessing the reported yellow card, patient chart review and interviewing with patient and physicians. World Health Organization definition for serious reactions was used to determine the seriousness of the reaction. Naranjo algorithm was used to determine probability scale. The probability of the reaction was determined based on questionnaire of Schumock et al. The studied case is classified as a rare and serious but preventable reaction induced by intramuscular injection of iron dextran in a 32 year old woman. The probability of the reaction is appeared to be “probable” based on Naranjo algorithm. It seems that Iron dextran could cause serious and life threatening adverse effects. It is necessary for healthcare professionals to be informed of such rare but serious reaction in order to apply preventive actions.

  4. Parâmetros Ecocardiográficos e Sobrevida na Cardiopatia Chagásica com Disfunção Sistólica Importante

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    Daniela do Carmo Rassi

    2014-04-01

    Full Text Available Fundamento: O ecocardiograma fornece dados importantes na avaliação cardiológica de pacientes em insuficiência cardíaca. A identificação de parâmetros ecocardiográficos na cardiopatia chagásica grave auxiliaria na implementação terapêutica e na avaliação prognóstica. Objetivo: Correlacionar parâmetros ecocardiográficos com desfecho mortalidade cardiovascular em pacientes com fração de ejeção 70,71 mL/m2 foi associado ao aumento significativo na mortalidade (log rank p < 0,0001. Conclusão: O volume indexado do átrio esquerdo mostrou-se como único fator de predição independente de mortalidade nesta população de pacientes chagásicos e com disfunção sistólica importante.

  5. Vascular anatomy of the medial sural artery perforator flap: a new classification system of intra-muscular branching patterns.

    Science.gov (United States)

    Dusseldorp, Joseph R; Pham, Quy J; Ngo, Quan; Gianoutsos, Mark; Moradi, Pouria

    2014-09-01

    The medial sural artery perforator (MSAP) flap is a versatile fasciocutaneous flap. The main difficulty encountered when raising the MSAP flap is in obtaining adequate pedicle length during intra-muscular dissection. The objective of this study was to determine the pattern of intra-muscular course of the MSAP flap pedicle. 14 cadaveric specimens were dissected and CT angiograms of 84 legs were examined. The intra-muscular branching pattern and depths of the medial sural artery branches were analyzed. The number of perforators, position of the dominant perforator and both intra-muscular and total pedicle length were also recorded and compared to existing anatomical data. Three types of arterial branching pattern were identified within the medial gastrocnemius, demonstrating one (31%), two (59%) or three or more (10%) main branches. A dominant perforator from the medial sural artery was present in 92% of anatomical specimens (13/14). Vertically, the location of the perforator from the popliteal crease was on average 13 cm (±2 cm). Transversely, the perforator originated 2.5 cm (±1 cm) from the posterior midline. Using CT angiography it was possible in 10 consecutive patients to identify a more superficial intra-muscular branch and determine the leg with the optimal branching pattern type for flap harvest. This study is the first to describe the variability of the intra-muscular arterial anatomy of the medial head of gastrocnemius muscle. Surgeons utilizing the MSAP flap option should be aware of the possible branching pattern types and consequently the differing perforator distribution and depths of intra-muscular branches. Routine use of pre-operative CT angiogram may help determine which leg has the most favorable branching pattern type and intra-muscular course for flap harvest. Copyright © 2014 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

  6. Effect of weight, sex and hunting period on fatty acid composition of intramuscular and subcutaneous fat from wild boar

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    Artūras Šiukščius

    2012-04-01

    Full Text Available The study examined the influence of weight, sex and month of hunting on the fatty acid composition of intramuscular and subcutaneous fat from 49 free ranging wild boars hunted in Lithuania during the winter season. A total number of 27 and 25 fatty acids were identified in the intramuscular fat and subcutaneous tissue of wild boars, respectively. The weight of the wild boar had mainly affected only the levels of separate fatty acids both in the intramuscular and subcutaneous fat. Higher levels of saturated fatty acids (SFA were found in the intramuscular and subcutaneous fat of males compared with females. The effect of both weight and sex on the levels of fatty acids was higher in the subcutaneous fat than in the intramuscular fat. Weight, sex and hunting month had no effect on PUFA/SFA and n-6 PUFA/n-3 PUFA ratios in the intramuscular and subcutaneous fat. The atherogenic (AI and thrombogenic (TI indexes and hypocholesterolemic/hypercholesterolemic ratio in subcutaneous fat were more favorable in females compared with males and in the January hunting season than in November and December.

  7. Venezuelan equine encephalitis virus replicon particle vaccine protects nonhuman primates from intramuscular and aerosol challenge with ebolavirus.

    Science.gov (United States)

    Herbert, Andrew S; Kuehne, Ana I; Barth, James F; Ortiz, Ramon A; Nichols, Donald K; Zak, Samantha E; Stonier, Spencer W; Muhammad, Majidat A; Bakken, Russell R; Prugar, Laura I; Olinger, Gene G; Groebner, Jennifer L; Lee, John S; Pratt, William D; Custer, Max; Kamrud, Kurt I; Smith, Jonathan F; Hart, Mary Kate; Dye, John M

    2013-05-01

    There are no vaccines or therapeutics currently approved for the prevention or treatment of ebolavirus infection. Previously, a replicon vaccine based on Venezuelan equine encephalitis virus (VEEV) demonstrated protective efficacy against Marburg virus in nonhuman primates. Here, we report the protective efficacy of Sudan virus (SUDV)- and Ebola virus (EBOV)-specific VEEV replicon particle (VRP) vaccines in nonhuman primates. VRP vaccines were developed to express the glycoprotein (GP) of either SUDV or EBOV. A single intramuscular vaccination of cynomolgus macaques with VRP expressing SUDV GP provided complete protection against intramuscular challenge with SUDV. Vaccination against SUDV and subsequent survival of SUDV challenge did not fully protect cynomolgus macaques against intramuscular EBOV back-challenge. However, a single simultaneous intramuscular vaccination with VRP expressing SUDV GP combined with VRP expressing EBOV GP did provide complete protection against intramuscular challenge with either SUDV or EBOV in cynomolgus macaques. Finally, intramuscular vaccination with VRP expressing SUDV GP completely protected cynomolgus macaques when challenged with aerosolized SUDV, although complete protection against aerosol challenge required two vaccinations with this vaccine.

  8. Autoridade docente: repensar um conceito

    Directory of Open Access Journals (Sweden)

    Thiago Miranda dos Santos Moreira

    Full Text Available Resumo Vivemos uma crise de autoridade no mundo moderno e seu impacto no âmbito educacional tem sido objeto de análises e críticas sob diferentes perspectivas. De acordo com Hannah Arendt, esse não é um fenômeno gerado na esfera da educação, não obstante, seu impacto nesse âmbito apareça aos olhos da autora como o sintoma mais evidente da profundidade e seriedade desta crise. Este trabalho tem por objetivo analisar o conceito de autoridade na obra de Hannah Arendt, propondo uma abordagem que busca romper com as perspectivas que veem a autoridade como um epifenômeno do poder. Desse modo, busca-se lançar um olhar sobre a autoridade como um elemento consubstancial à educação e não como um mero instrumento de poder, submissão e sujeição de indivíduos. Assim, num primeiro momento, será apresentada a perspectiva de Alain Renaut, filósofo francês que, em sua abordagem da autoridade, dialoga direta e criticamente com Arendt. Em seguida, será apresentada a origem do conceito sob a perspectiva de Hannah Arendt, bem como sua relação com a educação.

  9. Determination of α-tocopherol in pork with high intramuscular fat content

    Directory of Open Access Journals (Sweden)

    Rey, A.

    1996-10-01

    Full Text Available Extraction of α-tocopherol from pork samples with low (3% (LF or high (9% (HF amount of intramuscular fat have been carried out by three different methods, two of them based in saponification plus extraction of α-tocopherol and the other one without saponification. All samples were spiked with five different amount of α-tocopherol prior to analysis. In LF samples, recovery was in the range 85-95% in all cases, with not significant differences between methods. Recovery was much lower in HF samples when using methods which involve prior saponification of muscle samples (50-60%. Changes in KOH concentration did not improve markedly the recovery. The method based on direct extraction provided much better recovery in HF samples (85- 92% and consequently is recommended for samples high in fat.

    Se han utilizado tres métodos de cuantificación de α-tocoferol en muestras de tejido muscular de cerdos con un contenido en grasa intramuscular del 3% (LF y del 9% (HF. Dos de los métodos saponifican la muestra antes de extraer el α-tocoferol, y el tercero utiliza una extracción directa con solventes. Antes del análisis se añadieron cinco cantidades de α-tocoferol en cada caso. La recuperación del α-tocoferol en las muestras de bajo contenido en grasa intramuscular fue en todos los casos alrededor del 85-95%, sin encontrarse diferencias según el método utilizado. En las muestras con alto contenido en grasa intramuscular la recuperación fue mucho menor cuando se utilizaron los métodos que saponifican la muestra (50-60%. Al añadir mayor concentración de KOH no se mejoró sustancialmente la recuperación. El método basado en extracción directa con solventes proporcionó una recuperación superior (85-92% y es por tanto el que se recomienda para muestras con alto contenido en grasa intramuscular.

  10. Um crime delicado: conversando aos infinitos - "Um retrato de cavalo"

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    Cid Ottoni Bylaardt

    2010-12-01

    um cavalo e seu retrato, a partir dos sentimentos contraditórios de seu dono, que considera um crime aquele clique. Temos aí um retrato, imagem subtraída ilicitamente ao seu dono: escrita, representação. Temos também uma narrativa, escrita do retrato, representação da representação. Este artigo pretende mostrar como Guimarães Rosa manipula as ambiguidades da linguagem literária, levando-a além dos limites da representação, explorando seu fascínio, seu saber, que não é da ordem da compreensão. O cavalo e seu retrato fazem refletir sobre a literatura, sobre seu excesso de verdade que compõe sua mentira. Ao escrever o cavalo e seu retrato, o texto não consegue fixar nenhuma verdade, apenas imagens fugidias que compõem recapítulos: há sempre um escrito a se sobrepor a outro, sem determinar onde está o verdadeiro, onde está o que o nega, a remeter o olhar ao reino da fascinação, onde a imagem perde o valor de significação para se tornar pura paixão da indeterminação, da indiferença.

  11. El problema judío en la mente de tres importantes personajes del siglo VII : un papa, un obispo español y un rey visigodo

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    Ángel Riesco Terrero

    1993-01-01

    Full Text Available El «antisemitismo» y más concretamente el «antijudaísmo», aparte de fenómeno complejo, es tan antiguo y nuevo como el propio pueblo de Israel. Pero tal vez sea más importante caer en la cuenta de que esa animadversión, a veces, odio, indiferencia, antipatía, persecución... ha actuado como eficaz revulsivo, convirtiéndose para muchos en afecto, simpatía y admiración o, por lo menos, en una de las causas principales y de mayor interés por la historia del pueblo judío.

  12. A comparison of the effect of intranasal desmopressin and intramuscular hyoscine N-butyl bromide combination with intramuscular hyoscine N-butyl bromide alone in acute renal colic

    Directory of Open Access Journals (Sweden)

    Abdol-Reza Kheirollahi

    2010-01-01

    Full Text Available Background: Patients with acute renal colic usually require immediate diagnosis and treatment. In this clinical trial analgesic effect of hyoscine N-butyl bromide and desmopressin combination in comparison with hyoscine N-butyl bromide alone in patients with acute renal colic induced by urinary stones was assessed. Methods: The study included 114 patients randomly allocated in two groups (A and B. Patients in group A received 20 mg intramuscular hyoscine N-butyl bromide at admission time and patients in group B received 20 μg of intranasal desmopressin in combination with 20 mg intramuscular hyoscine N-butyl bromide. A visual analogue scale (VAS; a 10-cm horizontal scale ranging from "zero or no pain" to "10 or unbearable pain" was hired to assess the patients′ pain severity at baseline, 30 and 60 minutes after the treatments. Results: On admission, the pain level was similar in both groups (group A: 8.95 ± 0.11 and group B: 8.95 ± 0.12. In group A, the mean of pain level showed a decrease after 30 minutes (group A: 7.26 ± 0.25 and group B: 5.95 ± 0.28 but further decreasing did not occur; however in group B, the pain consistently decreased and the mean after 60 minutes was significantly decreased (group A: 6.80 ± 0.31 and group B: 3.71 ± 0.31. No side effects were detected in this study. Conclusions: The combination of hyoscine N-butyl bromide and desmopressin is more effective than hyoscine N-butyl bromide alone in patients with renal colic. Further studies are recommended to validate these findings and compare the different doses of desmopressin.

  13. Monorquidismo em um equino marchador

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    Jéssica Fontana de Magalhães

    2015-06-01

    Full Text Available O monorquidismo é um quadro raramente descrito em equinos, que não apresenta descrições prévias na literatura nacional. Trata-se de um equino adulto brasileiro, com oito anos de idade, sem raça definida, porém com características de raças de origem nacional. Por abordagem inguinal do lado esquerdo, localizou-se a túnica vaginal intacta, que, aberta, continha a cauda de um epidídimo mal formado, o ducto deferente e um delgado pedículo vascular, mas sem indícios de testículo. Exames histológicos e hormonais confirmaram a ausência de tecido testicular. Conclui-se que os exames histológicos e hormonais são essenciais para o diagnóstico de monorquidismo que, apesar de raro, também pode acometer equinos nacionais

  14. SEMIOSE DE UM PARADOXO COMUNICATIVO

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    Mauricius Martins Farina

    2008-06-01

    Full Text Available Este ensaio perscruta uma noção de real e de ficção em que ambos surgem como representação, num processo de semiose considerada um paradoxo comunicativo. O jornalismo contemporâneo é também uma mercadoria, um sistema complexo de comunicação, seu produto é a realidade construída com argumentos estereotipados por interesses editoriais pautados por interesses políticos e comerciais, simulacro de um conteúdo que não reflete, mas cria a necessidade no receptor. Também a realidade construída pelas imagens contemporâneas não é comunicação no sentido designativo, mas expressão de um simulacro que, como tal, ao negar a fantasia, recalca a realidade como uma ficção, operando num sistema de códigos numéricos que surgem como imagem num espaço visual transduzido da sua indexalidade para a virtualidade.

  15. O Brasil, um ano depois

    Directory of Open Access Journals (Sweden)

    AMADO LUIZ CERVO

    2011-09-01

    Full Text Available O presente artigo busca analisar as modificações ocorridas na posição brasileira no que se refere ao atentado de 11 de setembro de 2001, decorrido um ano desde sua realização.

  16. Molecular Factors Underlying the Deposition of Intramuscular Fat and Collagen in Skeletal Muscle of Nellore and Angus Cattle.

    Science.gov (United States)

    Martins, Taiane S; Sanglard, Letícia M P; Silva, Walmir; Chizzotti, Mário L; Rennó, Luciana N; Serão, Nick V L; Silva, Fabyano F; Guimarães, Simone E F; Ladeira, Márcio M; Dodson, Michael V; Du, Min; Duarte, Marcio S

    2015-01-01

    Studies have shown that intramuscular adipogenesis and fibrogenesis may concomitantly occur in skeletal muscle of beef cattle. Thus, we hypothesized that the discrepancy of intramuscular fat content in beef from Nellore and Angus was associated with differences in intramuscular adipogenesis and fibrogenesis during the finishing phase. To test our hypothesis, longissimus muscle samples of Nellore (n = 6; BW = 372.5 ± 37.3 kg) and Angus (n = 6; BW = 382.8 ± 23.9 kg) cattle were collected for analysis of gene and protein expression, and quantification of intramuscular fat and collagen. Least-squares means were estimated for the effect of Breed and differences were considered at P ≤ 0.05. A greater intramuscular fat content was observed in skeletal muscle of Angus compared to Nellore cattle (P≤0.05). No differences were observed for mRNA expression of lipogenic and lipolytic markers ACC, FAS, FABP4, SERBP-1, CPT-2, LPL, and ACOX (P > 0.05) in skeletal muscle of Nellore and Angus cattle. Similarly, no differences were observed in mRNA expression of adipogenic markers Zfp423, PPARγ, and C/EBPα (P>0.05) However, a greater PPARγ protein content was observed in skeletal muscle of Angus compared to Nellore cattle (P≤0.05). A greater abundance of adipo/fibrogenic cells, evaluated by the PDGFRα content, was observed in skeletal muscle of Angus than Nellore cattle (P≤0.05). No differences in fibrogenesis were observed in skeletal muscle of Angus and Nellore cattle, which is in accordance with the lack of differences in intramuscular collagen content in beef from both breeds (P>0.05). These findings demonstrate that difference in intramuscular fat content is associated with a slightly enhanced adipogenesis in skeletal muscle of Angus compared to Nellore cattle, while no difference in fibrogenesis.

  17. SIMULINVE – Um simulador de inventário para um centro de distribuição de peças

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    Heráclito Lopes Jaguaribe Pontes

    2008-10-01

    Full Text Available No mercado globalizado atual, as empresas buscam garantir disponibilidade de produto ao cliente final, com o menor nível de inventário possível. As ferramentas de simulação disponibilizam aos gestores melhores visões do negócio e melhores condições para a tomada de decisão. Em um Centro de Distribuição de Peças (CDP, para se alcançar um melhor desempenho no gerenciamento do inventário é importante poder contar com uma ferramenta capacitada para realizações de simulações de possíveis cenários. Este trabalho teve como objetivo desenvolver um processo para gerenciamento de inventario que resultou em um simulador de inventário para CDP. O simulador realiza projeções visando obter como resultados a previsão de demanda, a política de reposição das peças, o percentual de atendimento dos pedidos, os meses de inventário, a quantidade de Scrap e a quantidade de peças. O simulador foi submetido a experimentos com três cenários diferentes e os resultados confirmaram a qualidade do sistema de simulação proposto.

  18. Reality show: um paradoxo nietzschiano

    Directory of Open Access Journals (Sweden)

    Ilana Feldman

    2011-01-01

    Full Text Available

    O fenômeno dos reality shows - e a subseqüente relação entre imagem e verdade - assenta-se sobre uma série de paradoxos. Tais paradoxos podem ser compreendidos à luz do pensamento do filósofo alemão Friedrich Nietzsche, que, através dos usos de formulações paradoxais, concebia a realidade como um mundo de pura aparência e a verdade como um acréscimo ficcional, como um efeito. A ficção é então tomada, na filosofia de Nietzsche, não em seu aspecto falsificante e desrealizador - como sempre pleiteou nossa tradição metafísica -, mas como condição necessária para que certa espécie de invenção possa operar como verdade. Sendo assim, a própria expressão reality show, através de sua formulação paradoxal, engendra explicitamente um mundo de pura aparência, em que a verdade, a parte reality da proposição, é da ordem do suplemento, daquilo que se acrescenta ficcionalmente - como um adjetivo - a show. O ornamento, nesse caso, passa a ocupar o lugar central, apontando para o efeito produzido: o efeito-de-verdade. Seguindo, então, o pensamento nietzschiano e sua atualização na contemporaneidade, investigaremos de que forma os televisivos “shows de realidade” operam paradoxalmente, em consonância com nossas paradoxais práticas culturais.

  19. Uma arquitetura de um sistema learning companion para ensino a distância

    OpenAIRE

    Faraco, Rafael Avila

    2003-01-01

    Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de Produção. Atualmente o ensino a distância constitui-se em uma modalidade de ensino importante no sentido em que procura atender a uma demanda por capacitação contínua de um público que sofre com a concorrência acirrada, mercado de trabalho competitivo, falta de tempo e dificuldade de acesso à informação com qualidade. A evolução do ensino a distância, acompanhada pela ...

  20. Universidades corporativas e vantagens competitivas: um estudo multicaso em franquias brasileiras

    OpenAIRE

    Jaercio Alex Silva Barbosa

    2016-01-01

    O conhecimento tem se mostrado como uma importante fonte de vantagem competitiva para as organizações. Por isso, as empresas buscam, cada vez mais, mecanismos que alavanquem os processos de geração, gestão e disseminação do conhecimento organizacional. Uma das ferramentas, que pode potencializar a transformação do conhecimento em vantagens competitivas, é a universidade corporativa. Nesse contexto, as franquias surgem como um dos objetos de estudos que podem ajudar a explicar esta relação, po...

  1. Intramuscular diclofenac vs periprostatic lidocaine injection for controlling pain undergoing transrectal ultrasound guided prostatic biopsy

    International Nuclear Information System (INIS)

    Alam, S.I.

    2017-01-01

    Background: Transrectal ultrasound (TRUS) technique for getting prostatic tissue for histopathology is now the standard procedure for malignant lesions of the prostate and imperative diagnostic investigation of patients with clinical specks of prostatic neoplasia. During TRUS guided biopsy, pain control has been important issue therefore, highly potent analgesia before this procedure should be considered on high priority according to current census. Therefore, we compared intramuscular diclofenac injection with sensory blockade of injection lidocaine to abolish pain undergoing prostatic biopsy with TRUS technique. Methods: Total 200 patients were selected for this study having raised PSA values and suspicious nodule on Digital Rectal Examination. These patients were segregated into two groups by randomization. Group Ar eceived intramuscular diclofenac and group Bw ere infiltrated with lidocaine injection for sensory blockade. Results: Patients in group A was having mean age of 64.5±5.8 years while for group B patients was 65.6±4.9 years (p=0.16). Both groups have statistically insignificant difference in their mean PSA values (p=0.24) and mean prostatic volume (p=0.22). The mean pain scores on visual analogue scale in groups A was 3.5±0.8 and in group B it was 2.4±0.8 (p<0.001). 60% group A patients reported with mild or no pain compared to 90% in group B. (p<0.001). Conclusion: Local blockade with lidocaine injection has better pain control as compared to patients experienced pain with intramuscular diclofenac used for prostatic biopsy through TRUS technique.

  2. Real-time simultaneous and proportional myoelectric control using intramuscular EMG

    Science.gov (United States)

    Smith, Lauren H.; Kuiken, Todd A.; Hargrove, Levi J.

    2014-12-01

    Objective. Myoelectric prostheses use electromyographic (EMG) signals to control movement of prosthetic joints. Clinically available myoelectric control strategies do not allow simultaneous movement of multiple degrees of freedom (DOFs); however, the use of implantable devices that record intramuscular EMG signals could overcome this constraint. The objective of this study was to evaluate the real-time simultaneous control of three DOFs (wrist rotation, wrist flexion/extension, and hand open/close) using intramuscular EMG. Approach. We evaluated task performance of five able-bodied subjects in a virtual environment using two control strategies with fine-wire EMG: (i) parallel dual-site differential control, which enabled simultaneous control of three DOFs and (ii) pattern recognition control, which required sequential control of DOFs. Main results. Over the course of the experiment, subjects using parallel dual-site control demonstrated increased use of simultaneous control and improved performance in a Fitts’ Law test. By the end of the experiment, performance using parallel dual-site control was significantly better (up to a 25% increase in throughput) than when using sequential pattern recognition control for tasks requiring multiple DOFs. The learning trends with parallel dual-site control suggested that further improvements in performance metrics were possible. Subjects occasionally experienced difficulty in performing isolated single-DOF movements with parallel dual-site control but were able to accomplish related Fitts’ Law tasks with high levels of path efficiency. Significance. These results suggest that intramuscular EMG, used in a parallel dual-site configuration, can provide simultaneous control of a multi-DOF prosthetic wrist and hand and may outperform current methods that enforce sequential control.

  3. Computed tomographic measurement of gluteal subcutaneous fat thickness in reference to failure of gluteal intramuscular injections

    Energy Technology Data Exchange (ETDEWEB)

    Burbridge, B.E. [Univ. of Saskatchewan, Royal Univ. Hospital, Academic Dept. of Medical Imaging, Saskatoon, Saskatchewan (Canada)]. E-mail: brent.burbridge@usask.ca

    2007-04-15

    Casual observation of gluteal region fat thickness on computed tomography (CT) of the pelvis leads to the hypothesis that, in some individuals intended intramuscular injections are not properly deposited in the gluteal muscle. We gathered and analyzed data to determine whether this hypothesis was true. CT scans of the pelvis were analyzed over an 18-day period in the tall of 2005. The thickness of gluteal region subcutaneous fat was measured in a standardized manner. Measurement of gluteal region subcutaneous fat thickness was performed for 298 pelvic CT scans. There were 150 male subjects and 148 female subjects. The average gluteal fat thickness for female subjects was 33.2 mm, whereas the average for male subjects was 23.1 mm. Analysis revealed a significant difference in gluteal region fat thickness between male and female subjects. A 37-mm needle, allowing for 6-mm penetration of the gluteal muscle, would not have entered the gluteal muscle fibres in 81 of 148 female subjects (54.7%), in 21 of 150 male subjects (14%), and in 102 of the 298 total sample (34.2%). Analysis revealed a significant difference between male and female subjects with regard to gluteal muscle needle penetration. An overall predicted failure rate of 34% was identified for intended gluteal intramuscular injections when the standard technique was used. This is important information for care providers who inject medications in the gluteal region. In a significant number of patients, the medications will be injected subcutaneously and not into the gluteal musculature, possibly altering the pharmacokinetics of the administered medication. An alternative injection site should probably be chosen to increase the success rate of intramuscular deposition of medications and vaccines in unselected adults. (author)

  4. Giant intramuscular lipoma of the tongue: a case report and literature review.

    Science.gov (United States)

    Colella, Giuseppe; Biondi, Paolo; Caltabiano, Rosario; Vecchio, Giada Maria; Amico, Paolo; Magro, Gaetano

    2009-06-22

    We herein report a rare case of giant intramuscular lipoma of the tongue. A 75-year-old Italian male presented at our department with a large tumor at the tip of the tongue that had been present for over 30 years. Clinical examination revealed a yellowish lesion, measuring 10 cm in maximum diameter, protruding from lingual surface. Histological examination showed an unencapsulated lipomatous tumor composed of mature adipocytes, uniform in size and shape, diffusely infiltrating striated muscle fibers of the tongue. The patient is well with no local recurrence after a 15-month follow-up period.

  5. Evaluation of calcium di-sodium EDTA intramuscular injection using gamma scintigraphy against heavy metal poisoning

    International Nuclear Information System (INIS)

    Kumar, N.; Soni, S.; Mehra, L.; Mittal, G.; Nishad, D.K.; Bhatnagar, A.; Singh, T.; Ahmad, F.J.

    2010-01-01

    Full text: Heavy metals become toxic when they are not metabolized by the body and accumulate in soft tissues. These metals may enter the body through food, water, air or absorption through skin when an individual is exposed to areas with high heavy metal content such as agriculture, pharmaceutical manufacturing, paint and heavy metal industries or residential settings. Majority of population commonly get affected by heavy metal poisoning. Heavy metal poisoning is more likely to result through inhalation or ingestion route. Aim of the present study is to provide an easy, effective and controlled chelating therapy against heavy metal using Ca-disodium EDTA intramuscular injection. Ca-disodium-EDTA and Sesame oil were procured from Merck, India and Sigma Aldrich, USA respectively. Ca-Na 2 EDTA radiolabeling with 99m Tc-pertechnetate was standardized using stannous ions as reducing agent. The hypothesis of present work is to maintain effective concentration of chelating agent in blood for prolong time period. To test this hypothesis, we studied 1% Ca-Na 2 EDTA blood bioavailability after intramuscular depot administration in new zealand white rabbit. The optimized radiolabeled intramuscular formulation was evaluated for its dissolution and permeation studies in isotonic buffer solution were envisaged through radiometry. Sub-acute toxicity studies were performed after a single dose intramuscular administration of 1% Ca-Na 2 EDTA in Sprague Dawley rats. Radiolabeled Ca-disodium-EDTA (>95% labeled) was found to be fairly stable up to 24 h in physiological solution (Serum) as well as in normal saline with negligible degradation of 2.5% and 5.0% respectively, thereby indicating high stability of radiolabeled product. In-vitro data indicates that control release pattern (Cmax 24 hrs) with effective concentration up to seven days. 99m Tc-CaNa 2 EDTA retention at depot site was estimated up to 3 days by scintigraphy. Subacute toxicity studies done by histopathological

  6. Artesunate Suppositories versus Intramuscular Artemether for Treatment of Severe Malaria in Children in Papua New Guinea

    OpenAIRE

    Karunajeewa, Harin A.; Reeder, John; Lorry, Kerry; Dabod, Elizah; Hamzah, Juliana; Page-Sharp, Madhu; Chiswell, Gregory M.; Ilett, Kenneth F.; Davis, Timothy M. E.

    2006-01-01

    Drug treatment of severe malaria must be rapidly effective. Suppositories may be valuable for childhood malaria when circumstances prevent oral or parenteral therapy. We compared artesunate suppositories (n = 41; 8 to 16 mg/kg of body weight at 0 and 12 h and then daily) with intramuscular (i.m.) artemether (n = 38; 3.2 mg/kg at 0 h and then 1.6 mg/kg daily) in an open-label, randomized trial with children with severe Plasmodium falciparum malaria in Papua New Guinea (PNG). Parasite density a...

  7. Intramuscular pressure and EMG relate during static contractions but dissociate with movement and fatigue

    DEFF Research Database (Denmark)

    Sjøgaard, Gisela; Jensen, Bente R.; Hargens, Allan R.

    2004-01-01

    Intramuscular pressure (IMP) and electromyography (EMG) mirror muscle force in the nonfatigued muscle during static contractions. The present study explores whether the constant IMP-EMG relationship with increased force may be extended to dynamic contractions and to fatigued muscle. IMP and EMG...... with speed of abduction. In the nonfatigued supraspinatus muscle, a linear relationship was found between IMP and EMG; in contrast, during fatigue and recovery, significant timewise changes of the IMP-to-EMG ratio occurred. The results indicate that IMP should be included along with EMG when mechanical load...... sharing between muscles is evaluated during dynamic and fatiguing contractions....

  8. Tissue Disposition and Withdrawal Time of Fosfomycin in Swines after Oral and Intramuscular Administration

    OpenAIRE

    Pérez, Denisa Soledad; Soraci, Alejandro Luis; Tapia, Maria Ofelia

    2016-01-01

    A HPLC-MS/MS method, which was suitable to be used in withdrawal time studies, was validated for the determination of fosfomycin in swine muscle, liver, kidney and skin-fat. Therefore, the withdrawal time of fosfomycin in swines, considering a MRL of 0.5 μg/mL was studied. Forty-eight pigs were assigned to two groups; in group one, fosfomycin was orally administered daily with 30 mg⁄kg bw and to the other group a dose of 15 mg⁄kg bw of the antibiotic was intramuscularly administered. Pigs wer...

  9. Osteonecrose dos maxilares associada ao uso de bisfosfonatos: importante complicação do tratamento oncológico Bisphosphonate-associated jaws osteonecrosis: an important complication of oncology treatment

    Directory of Open Access Journals (Sweden)

    Marco Antonio T. Martins

    2009-02-01

    Full Text Available Os bisfosfonatos são um grupo de medicamentos utilizados no tratamento de doenças malignas metastáticas e em outras doenças ósseas como osteoporose e doença de Paget. A despeito dos seus benefícios, uma importante complicação denominada de osteonecrose dos maxilares vem sendo observada nos pacientes usuários crônicos dos bisfosfonatos que se caracteriza clinicamente por exposições ósseas na região maxilofacial persistente, acompanhadas de osteomielite, geralmente sintomáticas e cujo tratamento é complexo. Este estudo tem por objetivo revisar a literatura sobre a osteonecrose associada ao uso dos bisfosfonatos, em especial, em oncologia, no período de 2003 a 2008. Serão apresentados e discutidos os fatores de risco, aspectos etiopatogênicos, clínicos, imagenológicos, terapêuticos e preventivos desta doença. Devido à dificuldade de tratamento da osteonecrose associada aos bisfosfonatos, o foco deve ser a prevenção, sendo o ideal a eliminação de quadros infecciosos orais antes da terapia com os bisfosfonatos ter sido iniciada e minimizar traumas em boca após o uso destes medicamentos.Bisphosphonates are drugs used in the treatment of malignant metastatic diseases and in other bone lesions such as osteoporosis and Paget´s disease. Besides their benefits, jaw osteonecrosis, an important side effect, has been observed in long-term users of these drugs. Jaw osteonecrosis is clinically characterized by prolonged maxillary and mandible bone exposure accompanied by osteomyelitis. These lesions are usually symptomatic and difficult to treat. This study has the objective of reviewing publications from 2003 to 2008 about bisphosphonate-associated jaw osteonecrosis, in particular in relation to oncology. Risk factors, and etiopathological, clinical, radiographic, therapeutic, and preventive aspects of this condition are presented and discussed. Due to the difficulty to treat this disease, the focus must be prevention, with the

  10. Side effects and potential risk factors of botulinum toxin type A intramuscular injections in knee flexion contractures of hemophiliacs.

    Science.gov (United States)

    Rodriguez-Merchan, E Carlos; De la Corte-Rodriguez, Hortensia

    2017-07-01

    Knee flexion contracture (KFC) is a common complication of recurrent hemarthrosis in children and young adults with hemophilia. If the KFC is not prevented (by means of primary prophylaxis) and treated properly and early (be means of physical medicine and rehabilitation), it will become fixed. Areas covered: The aim of this article is to review the potential role of botulinum toxin type A (BTX-A) intramuscular injections for the treatment of KFC in people with hemophilia (PWH). Expert commentary: Although two recent reports have mentioned the benefits of intramuscular injections of BTX-A in PWH with KFC, the data are still scant and too preliminary. The use of intramuscular injections of BTX-A in PWH today should not be recommended until more case studies/small series (ideally well-designed clinical trials) fully demonstrate that this is safe and effective. The risks of intramuscular injections to a hemophilia patient cannot be underestimated (iatrogenic muscle hematomas and pseudotumors). This paper calls the attention of hemophilia treaters on the potential risks of this apparently interesting technique. The current use of BTX-A intramuscular injections in KFC of PWH could make no sense. Raising false expectations in these patients should be avoided.

  11. POSTPARTUM BOVINE ENDOMETRITIS TREATMENT BY INTRAUTERINE AND INTRAMUSCULAR ADMINISTRATION OF OXITETRACYCLINE TRATAMENTO DE ENDOMETRITE BOVINA PÓS PUERPERAL PELAS VIAS INTRAMUSCULAR E INTRA-UTERINA

    Directory of Open Access Journals (Sweden)

    Ciro Alexandre Alves Torres

    2009-07-01

    Full Text Available The aim of this study was to evaluate the efficiency of the postpartum bovine endometritis treatment by intrauterine and intramuscular administration of tetracycline. Forty six cross bred cows diagnosed by gynecological exam with postpartum endometritis were assigned randomly in two treatments: G1 (n=21 - animals were treated with one intramuscular (IM dose of tetracycline (20 mg/Kg of body weight, while in G2 (n=25 animals were treated with one intrauterine (IU dose of tetracycline (30 mg/Kg of body weight. No difference (p>0.05 was observed in the recovery rate between the two treatments (61.9 X 76.0%, G1 and G2, respectively. The interval from treatment until first estrous was 33.9±22.6 versus 14.8 ±10.9 days (P<0.05 and until first service was 54.7 ± 33.9 versus 27.2 ± 20.3 days (P<0.05; for G1 and G2, respectively. No difference (p>0.05 was observed in the number of services per conception between G1 (1.54 and G2 (1.3. The treatment cost was lower for the G1 (U$ 3.51 versus U$ 5.00. Although not to have had differences in the clinical recovery rate, the use of the oxitetracycline managed for way IU in the postpuerperal treatment of endometrites in cows revealed more efficient in the reduction of the interval between the treatment and first heat and first insemination, beyond presenting lower cost that the treatment with oxitetracycline managed for way IM

    KEY WORDS: Bovine, postpartum endometritis, intrauterine, intramuscular, oxitetracicline.
    Este trabalho teve por objetivo comparar a eficiência do uso da oxitetracilina, administrada pelas vias intramuscular (IM e intrauterina (IU, no tratamento de endometrites em vacas no período pós-puerperal. Foram utilizados 46 animais mestiços que apresentaram quadro clínico de endometrite, distribuídos aleatoriamente em dois tratamentos: G1 (n=21 – tratado com uma dose de 30 mg/Kg PV de oxitetraciclina por via IM, e G2 (n=25  – uma infusão de 20 mg/Kg PV de

  12. Formar melhor para um melhor cuidar

    Directory of Open Access Journals (Sweden)

    Manuela Maria da Conceição Ferreira

    2016-02-01

    Full Text Available A formação surge como uma ajuda ao desenvolvimento humano, adoptando uma posição abrangente que inclui o aluno e o próprio professor (Kohlberg e Mayer, 1972, em que o resultado obtido é menos importante do que a disponibilidade gerada durante o percurso, para que o aluno possa continuar a evoluir ao longo da vida. Esta perspectiva desenvolvimentalista, antecipava já, a tendência actual que defende que a educação deve constituir para cada indivíduo uma forma de promover o máximo desenvolvimento das suas potencialidades, através de experiências de aprendizagem de complexidade crescente. A formação não é apenas uma instância de mediação das relações formador/formando ou equipa de formadores/grupo de formandos, mas uma instância de auto-mediação do formando com o seu mundo subjectivo, mediador do grupo de formação com as suas subjectividades, mediador do grupo com um projecto de acção através do qual ele se exterioriza (Correia, 1997: 25. A qualidade do desenvolvimento e das aprendizagens do ser humano e de toda a acção pedagógica e educativa passa de uma maneira determinante pela qualidade das relações pessoais e interpessoais estabelecidas no processo de ensino/aprendizagem (Tavares, 1996. O mesmo autor (p: 83 refere que o “educador antes de mais tem de ser uma pessoa que se dirige a outra pessoa e a ajuda a dar à luz - mais e melhor que a parteira – a sua própria identidade pessoal, como ser inteligente e livre, autor e actor do seu próprio destino de uma maneira autónoma e responsável”.

  13. Recursos informacionais: importante aliado no processo de elaboração dos planos de aulas 10.5007/1518-2924.2007v12n23p92

    Directory of Open Access Journals (Sweden)

    Wilse Arena da Costa

    2007-11-01

    Full Text Available Sabendo da importância dos recursos informacionais no setor educacional, especialmente para elaboração do plano de aulas pelos professores das séries iniciais, realizou-se uma pesquisa na Escola Municipal Anfilófio de Souza Campos - EMASC, na cidade de Itiquira, Mato Grosso – MT. Procurou-se identificar os recursos informacionais utilizados pelos professores para enriquecer o conteúdo de suas disciplinas e dinamizar o processo ensino/aprendizagem. Enfatizou-se também, a partir de uma abordagem teórico-referencial, o papel do bibliotecário como agente nucleador da biblioteca como instituição viva e participante do conhecimento e das práticas pedagógicas desenvolvidas pelo professor. De forma peremptória, os resultados mostraram a prioridade dada ao livro didático e o uso reduzido ou inadequado da biblioteca, dos recursos eletrônicos e dos sites direcionados à Educação. Porém, um fator constatado que faz muita diferença em qualquer instituição escolar, nos dias atuais, é a ausência de um bibliotecário na EMASC.

  14. Fitoterápicos: um mercado promissor

    Directory of Open Access Journals (Sweden)

    TRAUDI KLEIN

    2010-06-01

    Full Text Available

    Observa-se na Fitoterapia uma tendência de contribuição efetiva à saúde da população. Por consequência, a padronização de fitomedicamentos é um pré-requisito para a garantia da qualidade, bem como para a constância dos efeitos terapêuticos e segurança do usuário. A validação de processo analítico deve garantir, através de evidências experimentais, que o método atenda às exigências das aplicações analíticas, assegurando a confiabilidade dos resultados. Assim, os equipamentos e materiais de laboratório devem ser devidamente calibrados e o analista qualificado. As substâncias químicas de referência devem ser certificadas por compêndios oficiais, como as Farmacopeias ou por outros códigos autorizados pela legislação vigente.Tão importante quanto o desenvolvimento e validação de uma metodologia analítica é o posterior estudo de estabilidade, a fim de garantir que o produto mantenha sua qualidade durante toda vida útil. Para a obtenção de registro de um medicamento fitoterápico dentro dos padrões requeridos pela legislação faz-se necessário, portanto, a realização de diferentes testes para validação deste medicamento de forma a garantir sua segurança no uso, eficácia na utilização e qualidade do produto. Palavras-chave: Fitomedicamentos. Validação. Saúde Publica. Padronização. ABSTRACT Phytomedicines: a promising market There is an observable trend towards phytotherapy making a recognized effective contribution to public health. Consequently, the standardization of phytomedicines is a prerequisite for quality assurance and to ensure the consistency of therapeutic effects and safety of the user. Analytical method validation should ensure, through experimental testing, that the method meets the requirements of the analytical applications, ensuring the reliability of results. Thus, the equipment and laboratory materials must be properly calibrated and the analyst

  15. ¿Por qué es importante el género en la Pedagogía Crítica?

    Directory of Open Access Journals (Sweden)

    Consol Aguilar Ródenas

    2009-01-01

    Full Text Available El artículo muestra la necesidad de incluir desde la pedagogía crítica en el ámbito de la reforma educativa, no tan solo en la teoría, sino también en la práctica académica cotidiana, en la acción, el género como un elemento de transformación de las desigualdades sociales, mostrando algunos aspectos importantes de la relación entre conocimiento, poder y género que pueden ayudar a lograr esas transformaciones como, por ejemplo, el feminismo dialógico, la aportación de los feminismos a los estudios de las nuevas masculinidades o diversas investigaciones ligadas al análisis del curriculum educativo considerando la relación entre neoliberalismo, educación y género; la exclusión social; la relación entre género e interculturalidad y otro modelo de relación afectivo-sexual en la construcción de las identidades unido a la coeducación y el aprendizaje dialógico, recuperando el papel en política cultural y educativa del profesorado desde el compromiso.

  16. Fat embolism in liposuction and intramuscular grafts in rabbits Embolia gordurosa na lipoaspiração e enxertia intramuscular em coelhos

    Directory of Open Access Journals (Sweden)

    Victor Araujo Felzemburgh

    2012-05-01

    Full Text Available PURPOSE: To evaluate the effects of fat embolism in organs such as lung and liver. METHODS: Twenty rabbits underwent autologous intramuscular fat grafting in the right thigh after liposuction. The groups were determined according to the postoperative day that occurred in euthanasia: 60, 90 and 120 day. Then, lung and liver were excised and sent to the histopathology laboratory for analysis in search of late injury secondary to a prior event of fat embolism in the tissues. RESULTS: The results showed a change in the macroscopic sample with discoloration of the liver tissue heterogeneously. There were no changes consistent with embolic effect under the microscope. CONCLUSION: The option of performing a technique of fat grafting with a less traumatic surgical procedure can be considered protective against embolic events, with no impact to late embolic events on the tissues.OBJETIVO: Avaliar a repercussão da embolia gordurosa em órgãos como pulmão e fígado. MÉTODOS: Vinte coelhos foram submetidos à enxertia autóloga intramuscular de gordura em coxa direita após lipoaspiração. Os grupos foram determinados conforme os dias pós-operatórios (DPO em que ocorreu a eutanásia: 60 DPO, 90DPO, 120 DPO. Em seguida, o pulmão e o fígado foram ressecados e encaminhados ao laboratório de histopatologia para análise em busca de lesão tardia secundária a evento de embolia gordurosa prévia nos tecidos. RESULTADOS: Foi evidenciada uma alteração na amostra a analise macroscópica com alteração da coloração do tecido hepático de forma heterogênea. Não houve alterações compatíveis com repercussão de processo embólico à microscopia. CONCLUSÃO: A opção pela realização de uma técnica de lipoenxertia menos traumática e com pequeno tempo cirúrgico pode ser considerada protetora para eventos embólicos, não havendo repercussão embólica a tardiamente.

  17. Um documento interessante de 1930

    Directory of Open Access Journals (Sweden)

    Irina Vassilieff

    1977-09-01

    Full Text Available (primeiro parágrafo do texto No decorrer das pesquisas de campo que estamos realizando em Varpa, a fim de instrumentar uma eventual monografia de Mestrado, topamos com o original de uma ata de eleição realizada a 1 de março de 1930. Trata-se de um documento que, salvo melhor juizo, poderia ser uma janela, se bem que modesta, aberta aos estudiosos de um vetor das instituições políticas brasileiras. E, ao veiculá-lo, abstemo-nos tanto de uma análise ideológica como de uma exercitação metodológica, limitando-nos apenas à simples localização, no esquema tradicional, de uma transcrição acompanhada de comentários.  O documento está arquivado na própria colônia de Varpa, que se localiza a 439 quilômetros da Capital do Estado de São Paulo em linha reta, e a 17 quilômetros de Tupã, à margem direita do rio do Peixe, constituindo atualmente um dos distritos do município de Tupã.

  18. Qualidade total: Um novo paradigma?

    Directory of Open Access Journals (Sweden)

    Suzana da Rosa Tolfo

    1999-01-01

    Full Text Available Nos últimos anos, o movimento para a implantação da Gestão da Qualidade Total vem crescendo ao redor do mundo. Em razão disso, há uma diversidade de ações realizadas com o nome de "Qualidade Total'. Uma revisão da teoria é complexa, porque existem muitos autores que tratam da questão. Eles escolhem diferentes perspectivas de análises (teóricas e empíricas e há dificuldades em se identificar um corpo conceitual. Há uma ampla difusão de modelos, ferramentas, técnicas, mercado e consultores. Essa popularidade, muitas vezes, faz com que determinadas organizações adotem essa forma de gestão do trabalho sem o conhecimento necessário das implicações que um modelo dessa ordem representa; especialmente no caso brasileiro, suscetível a proposições importadas. O presente artigo propõe um exame daquilo que os fundadores têm articulado sobre TQM, as principais críticas nesta direção e a avaliação de como vem sendo aplicadono nosso país.

  19. Tecnologia, especialização regional e produtividade: um estudo da pecuária leiteira em Minas Gerais

    Directory of Open Access Journals (Sweden)

    Mauro Borges Lemos

    2003-01-01

    Full Text Available Este trabalho pretende estabelecer um comparativo entre algumas microrregiões mineiras produtoras de leite, enfocando, sobretudo, características tecnológicas e de especialização. Trabalha-se com a idéia de que estas variáveis explicam em grande medida o diferencial de produção e produtividade do setor leiteiro, sendo importante o seu entendimento dentro do contexto de intensas mudanças as quais o setor vem passando nos últimos anos no Brasil. Desenvolvendo um estudo de dimensão espacial, pretende-se traçar um perfil da atividade em Minas Gerais, apontando os principais "gargalos" para o seu desenvolvimento e as perspectivas para a redução das desigualdades no setor.

  20. Haematological and biochemical alterations caused by epidural and intramuscular administration of xylazine hydrochloride in dromedary camels (Camelus dromedarius

    Directory of Open Access Journals (Sweden)

    Omid Azari

    2012-09-01

    Full Text Available This study was conducted in 16 healthy immature dromedary camels weighing 120-150 kg to evaluate and compare the effects of epidural and intramuscular injections of xylazine administered at 0.1 mg/kg and 0.2 mg/kg. Haematological parameters included haemoglobin, packed cell volume, total erythrocyte count and total leukocyte count. Biochemical parameters included alkaline phosphates, alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, creatinine and glucose. Parameters were measured at different intervals before (baseline and after the administration of drugs. Our study showed that the effect of xylazine on haematological and biochemical parameters is dose-dependant and is also related to the route of administration. The low dose of xylazine administered using both intramuscular and epidural methods showed minimal effects, whereas high doses of the drug, especially when injected intramuscularly, caused greater changes in haematological and biochemical parameters.

  1. Genetics of Marbling in Wagyu Revealed by the Melting Temperature of Intramuscular and Subcutaneous Lipids

    Directory of Open Access Journals (Sweden)

    Sally S. Lloyd

    2017-01-01

    Full Text Available Extreme marbling or intramuscular deposition of lipid is associated with Wagyu breeds and is therefore assumed to be largely inherited. However, even within 100% full blood Wagyu prepared under standard conditions, there is unpredictable scatter of the degree of marbling. Here, we evaluate melting temperature (Tm of intramuscular fat as an alternative to visual scores of marbling. We show that “long fed” Wagyu generally has Tm below body temperature but with a considerable range under standardized conditions. Individual sires have a major impact indicating that the variation is genetic rather than environmental or random error. In order to measure differences of lower marbling breeds and at shorter feeding periods, we have compared Tm in subcutaneous fat samples from over the striploin. Supplementary feeding for 100 to 150 days leads to a rapid decrease in Tm of 50% Red Wagyu (Akaushi : 50% European crosses, when compared to 100% European. This improvement indicates that the genetic effect of Wagyu is useful, predictable, and highly penetrant. Contemporaneous DNA extraction does not affect the measurement of Tm. Thus, provenance can be traced and substitution can be eliminated in a simple and cost-effective manner.

  2. [Intramuscular depot steroids : Possible treatment of postsurgical cystoid macula edema with steroid response?

    Science.gov (United States)

    Seuthe, A-M; Szurman, P; Boden, K T

    2017-11-01

    We report on a patient with postsurgical cystoid macular edema (CME) after phacoemulsification and multifocal intraocular lens (MIOL) implantation. At first, there was a very good reaction to intravitreal triamcinolone, inducing complete regression of the edema without increasing intraocular pressure (IOP). One year later the patient suffered from retinal detachment and was treated with vitrectomy, laser, and gas tamponade. Afterward, he developed macular pucker with edema. After surgical treatment with pucker peeling and intravitreal triamcinolone, the patient showed a steroid response and an increase IOP. Postoperatively, there was a recurrence of CME. A coincidental administration of a steroid injection intramuscularly by the general practitioner achieved a prompt reduction of the CME without increasing IOP. This case shows that an initially good reaction to triamcinolone without increasing IOP does not rule out a future steroid response, and that a potential treatment option for CME in patients with a known steroid response could consist of intramuscularly injected steroids.

  3. Pharmacokinetics of oral transmucosal and intramuscular dexmedetomidine combined with buprenorphine in cats.

    Science.gov (United States)

    Porters, N; de Rooster, H; Bosmans, T; Baert, K; Cherlet, M; Croubels, S; De Backer, P; Polis, I

    2015-04-01

    Plasma concentrations and pharmacokinetics of dexmedetomidine and buprenorphine after oral transmucosal (OTM) and intramuscular (i.m.) administration of their combination in healthy adult cats were compared. According to a crossover protocol (1-month washout), a combination of dexmedetomidine (40 μg/kg) and buprenorphine (20 μg/kg) was given OTM (buccal cavity) or i.m. (quadriceps muscle) in six female neutered cats. Plasma samples were collected through a jugular catheter during a 24-h period. Plasma dexmedetomidine and buprenorphine concentrations were determined by liquid chromatography-tandem mass spectrometry. Plasma concentration-time data were fitted to compartmental models. For dexmedetomidine and buprenorphine, the area under the plasma concentration-time curve (AUC) and the maximum plasma concentrations (Cmax ) were significantly lower following OTM than following i.m. administration. For buprenorphine, time to reach Cmax was also significantly longer after OTM administration than after i.m. injection. Data suggested that dexmedetomidine (40 μg/kg) combined with buprenorphine (20 μg/kg) is not as well absorbed from the buccal mucosa site as from the intramuscular injection site. © 2014 John Wiley & Sons Ltd.

  4. Delayed intramuscular human neurotrophin-3 improves recovery in adult and elderly rats after stroke.

    Science.gov (United States)

    Duricki, Denise A; Hutson, Thomas H; Kathe, Claudia; Soleman, Sara; Gonzalez-Carter, Daniel; Petruska, Jeffrey C; Shine, H David; Chen, Qin; Wood, Tobias C; Bernanos, Michel; Cash, Diana; Williams, Steven C R; Gage, Fred H; Moon, Lawrence D F

    2016-01-01

    There is an urgent need for a therapy that reverses disability after stroke when initiated in a time frame suitable for the majority of new victims. We show here that intramuscular delivery of neurotrophin-3 (NT3, encoded by NTF3) can induce sensorimotor recovery when treatment is initiated 24 h after stroke. Specifically, in two randomized, blinded preclinical trials, we show improved sensory and locomotor function in adult (6 months) and elderly (18 months) rats treated 24 h following cortical ischaemic stroke with human NT3 delivered using a clinically approved serotype of adeno-associated viral vector (AAV1). Importantly, AAV1-hNT3 was given in a clinically-feasible timeframe using a straightforward, targeted route (injections into disabled forelimb muscles). Magnetic resonance imaging and histology showed that recovery was not due to neuroprotection, as expected given the delayed treatment. Rather, treatment caused corticospinal axons from the less affected hemisphere to sprout in the spinal cord. This treatment is the first gene therapy that reverses disability after stroke when administered intramuscularly in an elderly body. Importantly, phase I and II clinical trials by others show that repeated, peripherally administered high doses of recombinant NT3 are safe and well tolerated in humans with other conditions. This paves the way for NT3 as a therapy for stroke. © The Author (2015). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  5. Riboflavin laurate nanosuspensions as an intramuscular injection for long-term riboflavin supplementation.

    Science.gov (United States)

    Du, Lina; Li, Guanglong; Jin, Yiguang; Wang, Lin; Xu, Qishou; Dong, Junxing

    2013-06-25

    The aim of this study was to prepare riboflavin laurate (RFL) nanosuspensions as an intramuscular injection for long-term riboflavin supplementation. Stable RFL nanosuspensions were obtained by injecting RFL/poloxamer solution in N,N-dimethyl formamide into a trehalose solution. Long soft nanostructures initially appeared and then tube-like rigid nanostructures were obtained after removal of solvents according to the transmission electron microscopic images. The nanosuspensions had narrow size distribution and the mean size was about 300 nm. Molecular self-assembly of RFL may drive the formation of nanostructures. RFL formed a monolayer at the air/water interface and poloxamer 188 could insert into the monolayer. The nanosuspensions were intramuscularly injected into rats to provide long-term riboflavin supplementation for more than 30 days in light of body weight, food intake, and urinary riboflavin. The nanosuspensions were also used to resist the riboflavin deficiency induced by methotrexate chemotherapy. RFL nanosuspensions are a promising nanomedicine for long-term riboflavin supplementation. Copyright © 2013 Elsevier B.V. All rights reserved.

  6. Quantification of intermuscular and intramuscular adipose tissue using magnetic resonance imaging after neurodegenerative disorders

    Institute of Scientific and Technical Information of China (English)

    Madoka Ogawa; Robert Lester; Hiroshi Akima; Ashraf S. Gorgey

    2017-01-01

    Ectopic adiposity has gained considerable attention because of its tight association with metabolic and cardiovascular health in persons with spinal cord injury (SCI). Ectopic adiposity is characterized by the storage of adipose tissue in non-subcutaneous sites. Magnetic resonance imaging (MRI) has proven to be an effective tool in quantifying ectopic adiposity and provides the opportunity to measure different adipose depots including intermuscular adipose tissue (IMAT) and intramuscular adipose tissue (IntraMAT) or in-tramuscular fat (IMF). It is highly important to distinguish and clearly define these compartments, because controversy still exists on how to accurately quantify these adipose depots. Investigators have relied on separating muscle from fat pixels based on their characteristic signal intensities. A common technique is plotting a threshold histogram that clearly separates between muscle and fat peaks. The cut-offs to separate between muscle and fat peaks are still not clearly defined and different cut-offs have been identified. This review will outline and compare the Midpoint and Otsu techniques, two methods used to determine the threshold between muscle and fat pixels on T1 weighted MRI. The process of water/fat segmentation using the Dixon method will also be outlined. We are hopeful that this review will trigger more research towards accurately quantifying ectopic adiposity due to its high relevance to cardiometabolic health after SCI.

  7. A comparison of the effect of intramuscular diclofenac, ketorolac or piroxicam on postoperative pain following laparoscopy.

    Science.gov (United States)

    O'Hanlon, J. J.; Beers, H.; Huss, B. K.; Milligan, K. R.

    1996-01-01

    Sixty patients presenting for in-patient gynaecological laparoscopic surgery were randomly allocated to receive either diclofenac 75 mg (n = 20), ketorolac 30 mg (n = 20) or piroxicam 20 mg (n = 20) as an intra-muscular injection immediately after induction of anaesthesia. Postoperative visual analogue scores over the first 24 hours, using a 10 cm scale, ranged from 3.2-0.5 in the diclofenac group, 2.7-0.85 in the ketorolac group and 2.8-0.5 in the piroxicam group. The scores did not differ significantly between the three groups (p > 0.05). Mean time (SD) to first analgesia was 27(94) minutes in the piroxicam group, 16 (30) minutes in the diclofenac group and 62 (120) minutes in the piroxicam group. Six out of twenty patients in the diclofenac group required further analgesia compared to nine out of twenty in the other two drug groups. This difference was not significant. There were no reports of increased bleeding, bronchoconstriction, bleeding from the upper gastrointestinal tract, renal impairment or pain from the intra-muscular injection site in any of the groups. The administration of a non-steroidal anti-inflammatory drug to patients presenting for laparoscopic surgery reduces postoperative pain. There were no obvious differences between the agents used. PMID:8686101

  8. Immunization of mice with gamma-irradiated intramuscularly injected schistosomula of Schistosoma mansoni

    International Nuclear Information System (INIS)

    Bickle, Q.D.; Taylor, M.G.; Doenhoff, M.J.; Nelson, G.S.

    1979-01-01

    The parameters involved in the induction of resistance against Schistosoma mansoni by injection of irradiated, artificially transformed schistosomula were studied in mice. Single intramuscular injections of 500 schistosomula exposed to radiation doses in the range 2.3 to 160 krad. resulted in significant protection ( in the range 20 to 50% as assessed by reduced worm burdens) against a challenge infection administered at intervals from 3 to 24 weeks post-vaccination. However, schistosomular irradiated with 20 krad. consistently resulted in better protection than those exposed to either higher or lower radiation doses despite the persistence of stunted adults from the infections irradiated with 2.3 krad. Vaccination with 40 krad. schistosomula resulted in significant protection in terms of reduced worm and tissue egg burdens and increased survival following lethal challenge. Varying the number of irradiated schistosomula, the frequency and route of their administration, the site of challenge and the strain of host all failed to enhance the level of resistance. However, percutaneously applied, irradiated cercariae were found to be more effective in stimulating resistance (60%) than intramuscularly injected, irradiated schistosomula (40%). (author)

  9. Genetics of Marbling in Wagyu Revealed by the Melting Temperature of Intramuscular and Subcutaneous Lipids

    Science.gov (United States)

    Valenzuela, Jose L.; Steele, Edward J.

    2017-01-01

    Extreme marbling or intramuscular deposition of lipid is associated with Wagyu breeds and is therefore assumed to be largely inherited. However, even within 100% full blood Wagyu prepared under standard conditions, there is unpredictable scatter of the degree of marbling. Here, we evaluate melting temperature (Tm) of intramuscular fat as an alternative to visual scores of marbling. We show that “long fed” Wagyu generally has Tm below body temperature but with a considerable range under standardized conditions. Individual sires have a major impact indicating that the variation is genetic rather than environmental or random error. In order to measure differences of lower marbling breeds and at shorter feeding periods, we have compared Tm in subcutaneous fat samples from over the striploin. Supplementary feeding for 100 to 150 days leads to a rapid decrease in Tm of 50% Red Wagyu (Akaushi) : 50% European crosses, when compared to 100% European. This improvement indicates that the genetic effect of Wagyu is useful, predictable, and highly penetrant. Contemporaneous DNA extraction does not affect the measurement of Tm. Thus, provenance can be traced and substitution can be eliminated in a simple and cost-effective manner. PMID:29201894

  10. Ivermectin disposition kinetics after subcutaneous and intramuscular administration of an oil-based formulation to cattle.

    Science.gov (United States)

    Lifschitz, A; Virkel, G; Pis, A; Imperiale, F; Sanchez, S; Alvarez, L; Kujanek, R; Lanusse, C

    1999-10-01

    Slight differences in formulation may change the plasma kinetics and ecto-endoparasiticide activity of endectocide compounds. This work reports on the disposition kinetics and plasma availability of ivermectin (IVM) after subcutaneous (SC) and intramuscular (IM) administration as an oil-based formulation to cattle. Parasite-free Aberdeen Angus calves (n = 24; 240-280 kg) were divided into three groups (n = 8) and treated (200 microg/kg) with either an IVM oil-based pharmaceutical preparation (IVM-TEST formulation) (Bayer Argentina S.A.) given by subcutaneous (Group A) and intramuscular (Group B) injections or the IVM-CONTROL (non-aqueous formulation) (Ivomec, MSD Agvet) subcutaneously administered (Group C). Blood samples were taken over 35 days post-treatment and the recovered plasma was extracted and analyzed by HPLC using fluorescence detection. IVM was detected in plasma between 12 h and 35 days post-administration of IVM-TEST (SC and IM injections) and IVM-CONTROL formulations. Prolonged IVM absorption half-life (p oil-based formulation examined in this trial, compared to the standard preparation, may positively impact on its strategic use in cattle.

  11. INFLUENCE OF INTRAMUSCULAR APPLICATION OF AUTOLOGOUS CONDITIONED PLASMA ON SYSTEMIC CIRCULATING IGF-1

    Directory of Open Access Journals (Sweden)

    Gert Schippinger

    2011-09-01

    Full Text Available Platelet-rich plasma (PRP to increase levels of platelets and growth factors has been used for the treatment of sports injuries suggesting to improve healing and regeneration. This method offers some potential especially for elite athletes. However, the insulin like growth factor-1 (IGF-1 is prohibited by the World Anti Doping Agency and, in addition, there may be a possible link between increased levels of IGF-1 and cancer risk. Aim of the study was to evaluate a systemic increase of IGF-1 after local intramuscular administration of PRP in young healthy moderately trained male subjects. Blood samples were drawn and PRP preparation was performed by means of centrifugation. Enriched plasma was injected into the gluteus muscle. Venous blood was collected and serum prepared before as well as after 0.5, 3 and 24 hours after PRP administration. IGF-1 analysis was performed applying an ELISA test kit. No significant systemic increase of mean IGF-1 was found after the PRP injection. Only one subject showed an increase after 24 h, but all IGF-1 values were found within reference limits. We conclude that a single intramuscular application of PRP does not significantly increase systemic IGF-1 levels. Therefore, a single application of PRP is safe with respect to systemic IGF-1 response and cancer risk and this should be allowed for treatment of muscle injuries in elite athletes

  12. Initial intramuscular perfusion pressure predicts early skeletal muscle function following isolated tibial fractures

    Directory of Open Access Journals (Sweden)

    Haas Norbert P

    2008-04-01

    Full Text Available Abstract Background The severity of associated soft tissue trauma in complex injuries of the extremities guides fracture treatment and decisively determines patient's prognosis. Trauma-induced microvascular dysfunction and increased tissue pressure is known to trigger secondary soft tissue damage and seems to adversely affect skeletal muscle function. Methods 20 patients with isolated tibial fractures were included. Blood pressure and compartment pressure (anterior and deep posterior compartment were measured continuously up to 24 hours. Corresponding perfusion pressure was calculated. After 4 and 12 weeks isokinetic muscle peak torque and mean power of the ankle joint in dorsal and plantar flexion were measured using a Biodex dynamometer. Results A significant inverse correlation between the anterior perfusion pressure at 24 hours and deficit in dorsiflexion at 4 weeks was found for both, the peak torque (R = -0.83; p Conclusion The functional relationship between the decrease in intramuscular perfusion pressures and muscle performance in the early rehabilitation period indicate a causative and prognostic role of early posttraumatic microcirculatory derangements and skeletal muscle function. Therapeutic concepts aimed at effective muscle recovery, early rehabilitation, and decreased secondary tissue damage, should consider the maintenance of an adequate intramuscular perfusion pressure.

  13. Magnetic resonance imaging of intramuscular myxoma with histological comparison and a review of the literature

    International Nuclear Information System (INIS)

    Luna, A.; Martinez, S.; Bossen, E.

    2005-01-01

    To evaluate the magnetic resonance (MR) features of intramuscular myxoma (IM) compared with its pathological findings. Two radiologists retrospectively reviewed records and imaging studies of patients with histologically proven IM. Two radiologists also analyzed by consensus all the MR studies (pre- and post-contrast T1-weighted and T2-weighted sequences) and a pathologist reviewed the available histological material. Seventeen patients with 18 histologically proven IM were reviewed. Histological samples of 11 of these 18 tumors were available for pathological analysis. There were 14 women and three men, with a mean age of 58.9 years. IM involved predominantly the thigh (n=10). MR imaging showed well-circumscribed intramuscular masses, hypointense on T1-weighted and hyperintense on T2-weighted images. Eleven masses were homogeneous and seven slightly heterogeneous due to fibrous septa. Enhanced MR imaging demonstrated three different patterns: peripheral enhancement (n=1), peripheral and patchy internal enhancement (n=7) or peripheral and linear internal enhancement (n=4). Intratumoral cysts were detected in four masses. MR imaging showed the presence of a pseudocapsule (n=12), fat around the lesion (n=16) and peritumoral edema (n=16). Histologically, all the tumors were hypocellular, hypovascular and myxoid. Peripheral areas of collagenous fibers formed a partial capsule and IM often merged into surrounding muscular fibers. More cellular tumors and those with scanty myxoid stroma tended to show a more prominent internal enhancement. IM shows several recognizable MR features which suggest its diagnosis. (orig.)

  14. A psicologia histórico-cultural soviética (1917-1991: problemas de paternidade associados a obras e autores importantes

    Directory of Open Access Journals (Sweden)

    Roberto Valdés Puentes

    2017-02-01

    Full Text Available Resumo: Mukhina e Venguer estão envolvidos em problemas de “paternidade”. Chegou-se a conclusão que os livros Temas de psicologia pré-escolar e Psicologia Pré-escolar, publicados por Venguer e Mukhina, respectivamente, são praticamente um único livro devido a seu conteúdo. Em tal sentido, recomenda-se que os autores sejam adequadamente citados, com base na edição específica, acrescida, no segundo caso, da problematização que existe em torno dessas obras e autores, bem como de uma posição que assumidamente reconheça que essas ideias e produções pertencem a dois cientistas diferentes. Palavras-chave: Psicologia Histórico-cultural. Ex-União Soviética. Petrovsky. Mukhina. Venguer.

  15. Selection for intramuscular fat and lean meat yield will improve the bloomed colour of Australian lamb loin meat.

    Science.gov (United States)

    Calnan, H B; Jacob, R H; Pethick, D W; Gardner, G E

    2017-09-01

    The colour of bloomed m. longissimus was measured 24h post slaughter for 8165 lamb carcasses produced over 5years across 8 sites in Australia. Intramuscular fat across a 2 to 8% range and shortloin fat weight were positively associated with meat lightness (L*), redness (a*), yellowness (b*), hue and chroma (Pmeat colour parameters (Pmeat yield will have neutral or positive effects on meat colour, while selection for increased intramuscular fat will make the bloomed colour of lamb meat lighter and redder. Copyright © 2017. Published by Elsevier Ltd.

  16. Intramuscular olanzapine versus intramuscular aripiprazole for the treatment of agitation in patients with schizophrenia: A pragmatic double-blind randomized trial.

    Science.gov (United States)

    Kittipeerachon, Mantana; Chaichan, Warawat

    2016-10-01

    To evaluate and compare the effectiveness and adverse effects of intramuscular (IM) olanzapine and IM aripiprazole for the treatment of agitated patients with schizophrenia in clinical practice. A 24-hour randomized double-blind study carried out at a psychiatric hospital in Thailand enrolled adult patients (18-65years old) with schizophrenia experiencing agitation. Patients received one dose of IM olanzapine or IM aripiprazole followed by routine oral psychotropic medications. Efficacy was primarily measured using the Excited Component of the Positive and Negative Syndrome Scale (PANSS-EC). A total of 80 patients with a PANSS-EC score range of 22-35 entered the study, of whom 13% had a medical comorbidity and 40% a history of active substance abuse. The 40 patients receiving IM olanzapine showed greater improvement than the 40 patients receiving IM aripiprazole in PANSS-EC scores at 2h after the injection (p=0.002) but not at 24h. The two treatments were well tolerated. Patients receiving IM olanzapine experienced greater somnolence than those receiving IM aripiprazole. There were no clinically relevant changes in vital signs in either group. The results indicate that IM olanzapine and aripiprazole are similarly effective and well tolerated in the real-world treatment of agitation associated with schizophrenia over the first 24h. However, in the early hours, IM olanzapine may produce more sedation and reductions in agitation. Copyright © 2016 Elsevier B.V. All rights reserved.

  17. Two Sudden and Unexpected Deaths of Patients with Schizophrenia Associated with Intramuscular Injections of Antipsychotics and Practice Guidelines to Limit the Use of High Doses of Intramuscular Antipsychotics

    Directory of Open Access Journals (Sweden)

    Nasratullah Wahidi

    2016-01-01

    Full Text Available Intravenous haloperidol has been associated with torsades de pointes (TdP. These two sudden deaths were probable adverse drug reactions (ADRs following intramuscular (IM antipsychotics. The autopsies described lack of heart pathology and were highly compatible with the possibility of TdP in the absence of risk factors other than the accumulation of antipsychotics with a high serum peak after the last injection, leading to death within hours. The first case was a 27-year-old African-American male with schizophrenia but no medical issues. His death was probably caused by repeated IM haloperidol injections of 10 mg (totaling 35 mg in 2 days. The second case involves a 42-year-old African-American female with metabolic syndrome. Her probable cause of death was the last ziprasidone IM injection of 20 mg in addition to (1 three extra haloperidol doses (2 hours before the ziprasidone injection, 5 mg oral haloperidol; approximately 21 hours earlier, 5 mg oral haloperidol; and 2 days prior, one 10 mg IM haloperidol injection, (2 10 mg/day of scheduled oral haloperidol for 6 days before death, and (3 a long-acting paliperidone injection of 156 mg 18 days before death. The study of haloperidol glucuronidation and its impairment in some African-Americans is urgently recommended.

  18. Acerca del cáncer cervicouterino como un importante problema de salud pública About uterocervical cancer as an important public health problem

    Directory of Open Access Journals (Sweden)

    Julio César Espín Falcón

    2012-12-01

    Full Text Available El cáncer se presenta como un importante problema de salud, dada la alta morbilidad y mortalidad que produce. Es uno de los procesos más complejos de la naturaleza y resulta el más complicado en la esfera de la medicina por su origen multicausal, la complejidad de sus mecanismos patogénicos y la variedad de formas y tipos que pueden originarse en el ser vivo. El objetivo de este trabajo es ofrecer información útil y actualizada acerca del cáncer cervicouterino. Esta enfermedad es prevenible y curable y se relaciona con la aparición del cáncer en vagina, cuello uterino, vulva y ano; en las mujeres se ha demostrado que la infección por el virus del papiloma humano es un factor de riesgo para su desarrollo. En la actualidad existen y se comercializan en el mundo dos tipos de vacuna, lo que se considera uno de los mayores avances en la medicina preventiva moderna. La aplicación de estas vacunas profilácticas contra el virus del papiloma humano podría reducir la incidencia y mortalidad por cáncer cervicouterino. Esta enfermedad constituye una de las entidades con más impacto y repercusión sobre la salud femenina, particularmente en las mujeres jóvenes. Está considerada una enfermedad emergente desde hace escasos años y sus consecuencias sociales, humanas y económicas lo convierten en un problema importante de salud pública y de la humanidad.Cancer represents an important health problem due to its high morbidity and mortality. It is one of the most complex processes of nature and the most complicated in medicine because of its multiple cause origin, the complexity of its pathogenic mechanisms and the variety of forms and types that may adopt in the subject alive. The objective of this paper was to provide useful and updated information on the uterocervical cancer. This disease is preventable and curable; it is related to the occurrence of cancer in the vagina, the uterine neck, the vulva and the anus. It has been proved that human

  19. A cobertura de ciência em três jornais paraenses: um estudo longitudinal

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    Vanessa Brasil de Carvalho

    Full Text Available Resumo Neste artigo, apresentamos uma proposta metodológica visando realizar um estudo longitudinal que fornecesse um panorama da cobertura de ciência em 130 anos, por três jornais importantes do Estado do Pará: A Província do Pará (1876-2002, Folha do Norte (1896-1974 e O Liberal (1946-atual. Analisamos um período de dois meses a cada dez anos, de 1876 a 2006, em cada jornal selecionado, de maneira que obtivemos um olhar em longo prazo que perpassou pela história dos periódicos e, portanto, por grande parte da história da imprensa no Pará e na Amazônia. Utilizamos análise de conteúdo e análise de frames da Mídia. Nossos dados mostram que houve ênfase na pesquisa em saúde, destaque para a ciência nacional e preocupação em contextualizar os fatos científicos. Controvérsias e incertezas científicas ganharam pouco espaço nos jornais analisados.

  20. DE BATESON A INGOLD: PASSOS NA CONSTITUIÇÃO DE UM PARADIGMA ECOLÓGICO

    Directory of Open Access Journals (Sweden)

    Otávio Velho

    2001-10-01

    Full Text Available Em 2000 foi finalmente reeditado o mais importante livro de Gregory Bateson, Steps to an Ecology of Mind. Nesse mesmo ano, foi lançado o livro de Tim Ingold, The Perception of the Environment, que retoma muitas das preocupações de Bateson. Este ensaio considera que esses dois eventos marcam passos importantes na constituição de um "paradigma ecológico", o qual vem responder a alguns dilemas que rondam a antropologia e abrir perspectivas para um diálogo interdisciplinar em novas bases.Gregory Bateson’s most important book, Steps to an Ecology of Mind, was finally re-edited in 2000. In the same year, Tim Ingold’s book, The Perception of the Environment, which takes up many of Bateson’s preocupations, was released. This essay proposes that these two events represent important steps towards an "ecological paradigm", which attempts to answer some of anthropology’s dilemas, and open up perspectives for interdisciplinary dialogue on new terms.

  1. Liver transcriptome profile in pigs with extreme phenotypes of intramuscular fatty acid composition

    Directory of Open Access Journals (Sweden)

    Ramayo-Caldas Yuliaxis

    2012-10-01

    Full Text Available Abstract Background New advances in high-throughput technologies have allowed for the massive analysis of genomic data, providing new opportunities for the characterization of the transcriptome architectures. Recent studies in pigs have employed RNA-Seq to explore the transcriptome of different tissues in a reduced number of animals. The main goal of this study was the identification of differentially-expressed genes in the liver of Iberian x Landrace crossbred pigs showing extreme phenotypes for intramuscular fatty acid composition using RNA-Seq. Results The liver transcriptomes of two female groups (H and L with phenotypically extreme intramuscular fatty acid composition were sequenced using RNA-Seq. A total of 146 and 180 unannotated protein-coding genes were identified in intergenic regions for the L and H groups, respectively. In addition, a range of 5.8 to 7.3% of repetitive elements was found, with SINEs being the most abundant elements. The expression in liver of 186 (L and 270 (H lncRNAs was also detected. The higher reproducibility of the RNA-Seq data was validated by RT-qPCR and porcine expression microarrays, therefore showing a strong correlation between RT-qPCR and RNA-Seq data (ranking from 0.79 to 0.96, as well as between microarrays and RNA-Seq (r=0.72. A differential expression analysis between H and L animals identified 55 genes differentially-expressed between groups. Pathways analysis revealed that these genes belong to biological functions, canonical pathways and three gene networks related to lipid and fatty acid metabolism. In concordance with the phenotypic classification, the pathways analysis inferred that linolenic and arachidonic acids metabolism was altered between extreme individuals. In addition, a connection was observed among the top three networks, hence suggesting that these genes are interconnected and play an important role in lipid and fatty acid metabolism. Conclusions In the present study RNA-Seq was used

  2. Controle de Qualidade dos Serv iços de Auditoria Independente: Um Estudo Compara tivo entre as Normas Brasileiras e as Normas Internacionais

    OpenAIRE

    Ito, Elisabeth Yukie Horita; Niyama, Jorge Katsumi; Mendes, Paulo César de Melo

    2008-01-01

    A atividade de auditoria independente exerce um papel importante no bom funcionamento do mercado por contribuir para maior confiabilidade das informações quanto à sua transparência e adequação de forma independente e com base em procedimentos técnicos e profissionais. Para assegurar a qualidade dos serviços prestados pela auditoria independente é necessário um efetivo controle de qualidade desses serviços. A mencionada qualidade está diretamente relacionada à independência e à compe...

  3. Controle de Qualidade dos Serv iços de Auditoria Independente: Um Estudo Compara tivo entre as Normas Brasileiras e as Normas Internacionais

    OpenAIRE

    Elisabeth Yukie Horita Ito; Jorge Katsumi Niyama; Paulo César de Melo Mendes

    2009-01-01

    A atividade de auditoria independente exerce um papel importante no bom funcionamento do mercado por contribuir para maior confiabilidade das informações quanto à sua transparência e adequação de forma independente e com base em procedimentos técnicos e profissionais. Para assegurar a qualidade dos serviços prestados pela auditoria independente é necessário um efetivo controle de qualidade desses serviços. A mencionada qualidade está diretamente relacionada à independência e à competênc...

  4. Melhoria de processos com recurso a ferramentas Lean : um caso prático numa indústria de calçado

    OpenAIRE

    Ramos, Patrícia Maria da Silva

    2015-01-01

    Nos dias de hoje as indústrias recorrem cada vez mais à filosofia lean, para atingir níveis de produtividade excelentes. Esta filosofia permite a uma empresa otimizar os seus recursos e eliminar ou minimizar desperdícios. A ergonomia é um fator importante nesta filosofia, uma vez que os recursos humanos são um fator chave na busca da melhoria contínua. O presente trabalho incide sobre a implementação de ferramentas lean com o objetivo de aumentar a eficiência e reduzir desperdícios no proc...

  5. Dermatite multifatorial em um canino

    Directory of Open Access Journals (Sweden)

    C.B. Matos

    2012-12-01

    Full Text Available Relatou-se um caso clínico de dermatite multifatorial em cão, envolvendo Demodex canis, Sporothrix schenckii e bactérias dos gêneros Staphylococcus e Streptococcus. O animal, macho, da raça Pit Bull, com um ano e três meses de idade, apresentou lesões úmidas, hiperêmicas, descamativas e ulcerativas nas regiões do pescoço e do tórax. Exames laboratoriais confirmaram o diagnóstico de infecção concomitante por fungo, bactéria e parasito. A terapia antimicrobiana com moxidectina, itraconazol e amoxicilina foi efetiva, com remissão dos sinais clínicos após 30 dias de tratamento. Este relato salienta a importância do diagnóstico de certeza, que foi determinante para estabelecimento da terapêutica adequada e recuperação do animal.

  6. Intramuscular degeneration process in Duchenne muscular dystrophy; Investigation by longitudinal MR imaging of the skeletal muscles

    Energy Technology Data Exchange (ETDEWEB)

    Hasegawa, Takeshi; Matsumra, Kiichiro (Shimoshizu National Hospital, Yotsukaido, Chiba (Japan)); Hashimoto, Takahiro; Ikehira, Hiroo; Fukuda, Hiroshi; Tateno, Yukio

    1992-03-01

    Intramuscular degeneration process of Duchenne dystrophy skeletal muscles was investigated by longitudinal skeletal muscle imaging with high-field-strength NMR-CT of 1.5 Tesla. Thigh muscles in 10 cases ranging in age from 4 to 19 years were examined by T{sub 1}-weighted longitudinal images (TR=215{approx}505 ms, TE=19{approx}20 ms). The following results were obtained. Skeletal muscle degeneration was depicted as high signal intensity area reflecting its high fat contents. These high signal intensity areas had a longitudinally streaky appearance in parallel direction with myofibers. These findings were more prominent toward myotendon junction than muscle bellies. Skeletal muscle degeneration progressed rapidly between 7 to 10 years of age, and reached a plateau after that. (author).

  7. Tissue distribution of enrofloxacin in African clawed frogs (Xenopus laevis) after intramuscular and subcutaneous administration.

    Science.gov (United States)

    Felt, Stephen; Papich, Mark G; Howard, Antwain; Long, Tyler; McKeon, Gabriel; Torreilles, Stéphanie; Green, Sherril

    2013-03-01

    As part of an enrofloxacin pharmacokinetic study, concentrations of enrofloxacin and ciprofloxacin (metabolite) were measured in various tissues (brain, heart, kidney, liver, lung, and spleen) collected from treated (subcutaneous delivery, n = 3; intramuscular delivery, n = 3; untreated controls, n = 2) adult female Xenopus laevis by using HPLC. Enrofloxacin was rapidly absorbed after administration by either route and readily diffused into all sampled tissues. Enrofloxacin and ciprofloxacin were present in the tissue samples collected at 8 h. The highest average tissue concentrations for enrofloxacin were found in kidney, with the lowest concentrations in liver. Ciprofloxacin tissue concentrations paralleled but were always lower than those of enrofloxacin for all time points and tissues except brain and kidney. These results, together with previously published pharmacokinetic data and known minimal inhibitory concentrations of common pathogenic bacteria, provide a strong evidence-based rationale for choosing enrofloxacin to treat infectious diseases in X. laevis.

  8. Pharmacokinetic-Pharmacodynamic Model To Evaluate Intramuscular Tetracycline Treatment Protocols To Prevent Antimicrobial Resistance in Pigs

    DEFF Research Database (Denmark)

    Ahmad, Amais; Græsbøll, Kaare; Christiansen, Lasse Engbo

    2015-01-01

    High instances of antimicrobial resistance are linked to both routine and excessive antimicrobial use, but excessive or inappropriate use represents an unnecessary risk. The competitive growth advantages of resistant bacteria may be amplified by the strain dynamics; in particular, the extent...... to which resistant strains outcompete susceptible strains under antimicrobial pressure may depend not only on the antimicrobial treatment strategies but also on the epidemiological parameters, such as the composition of the bacterial strains in a pig. This study evaluated how variation in the dosing...... protocol for intramuscular administration of tetracycline and the composition of bacterial strains in a pig affect the level of resistance in the intestine of a pig. Predictions were generated by a mathematical model of competitive growth of Escherichia coli strains in pigs under specified plasma...

  9. Pharmacokinetic-Pharmacodynamic Model To Evaluate Intramuscular Tetracycline Treatment Protocols To Prevent Antimicrobial Resistance in Pigs

    DEFF Research Database (Denmark)

    Ahmad, Amais; Græsbøll, Kaare; Christiansen, Lasse Engbo

    2015-01-01

    protocol for intramuscular administration of tetracycline and the composition of bacterial strains in a pig affect the level of resistance in the intestine of a pig. Predictions were generated by a mathematical model of competitive growth of Escherichia coli strains in pigs under specified plasma......High instances of antimicrobial resistance are linked to both routine and excessive antimicrobial use, but excessive or inappropriate use represents an unnecessary risk. The competitive growth advantages of resistant bacteria may be amplified by the strain dynamics; in particular, the extent...... to which resistant strains outcompete susceptible strains under antimicrobial pressure may depend not only on the antimicrobial treatment strategies but also on the epidemiological parameters, such as the composition of the bacterial strains in a pig. This study evaluated how variation in the dosing...

  10. Comparison between intravenous and intramuscular administration of ketamine in children sedation referred to emergency department

    Directory of Open Access Journals (Sweden)

    Behnaz Boroumand Rezazadeh

    2014-12-01

    Full Text Available Ketamine, among wide variety of sedative drugs, has shown beneficial effects when using during the procedural sedation, specifically in pediatrics. Various parameters should be considered in order to perform a safe and effective procedural sedation including optimum dosage of the sedative, administration methods of sedation, and need for applying any adjuvant drug. In this study, we aimed to review the studies, which have compared the efficacy of the different ways of the injection of ketamine such as intravenous or intramuscular ketamine application. Based on data obtained from the related articles, efficacy and safety of these two methods of ketamine usage in the pediatric procedural sedation were widely similar, but the intravenously administration of the ketamine can be proposed as the preferable mode.

  11. Comparison of liquid chromatographic and bioassay procedures for determining depletion of intramuscularly injected tylosin.

    Science.gov (United States)

    Moats, W A; Harris, E W; Steele, N C

    1985-01-01

    Crossbred pigs weighing 80-110 kg were injected intramuscularly in the ham with 8.8 mg/kg tylosin. Animals were slaughtered in groups of 3 at intervals of 4 h, and 1, 2, 4, and 8 days after injection, and samples of blood, injected muscle, uninjected muscle, liver, and kidney were analyzed by liquid chromatography (LC) and by bioassay using Sarcina lutea as the test organism. The LC method was far more sensitive with a detection limit of less than 0.1 ppm, while the detection limit by bioassay was about 0.5 ppm in tissue. Results by bioassay and LC sometimes differed considerably for tissue samples. Residues in all tissues were below the tolerance limit of 0.2 ppm at 24 h, except in the injected muscle in one animal. Residues were not detected in any tissue of any animal at 48 h after treatment.

  12. Prediction of intramuscular fat levels in Texel lamb loins using X-ray computed tomography scanning.

    Science.gov (United States)

    Clelland, N; Bunger, L; McLean, K A; Conington, J; Maltin, C; Knott, S; Lambe, N R

    2014-10-01

    For the consumer, tenderness, juiciness and flavour are often described as the most important factors for meat eating quality, all of which have a close association with intramuscular fat (IMF). X-ray computed tomography (CT) can measure fat, muscle and bone volumes and weights, in vivo in sheep and CT predictions of carcass composition have been used in UK sheep breeding programmes over the last few decades. This study aimed to determine the most accurate combination of CT variables to predict IMF percentage of M. longissimus lumborum in Texel lambs. As expected, predicted carcass fat alone accounted for a moderate amount of the variation (R(2)=0.51) in IMF. Prediction accuracies were significantly improved (Adj R(2)>0.65) using information on fat and muscle densities measured from three CT reference scans, showing that CT can provide an accurate prediction of IMF in the loin of purebred Texel sheep. Copyright © 2014. Published by Elsevier Ltd.

  13. Association between intramuscular fat in the arm following arm training and INSIG2

    DEFF Research Database (Denmark)

    Popadic Gacesa, J Z; Secher, N H; Momcilovic, M

    2014-01-01

    ) ; mean ± standard deviation) carried out a 12-week two-arm elbow extensor training (10 maximal extensions with 1 min recovery between bouts) five times per day, five times per week. For 17 volunteers, upper arm muscle and adipose tissue [subcutaneous (SCAT) and intramuscular (IMAT)] volumes were.......0 ± 0.9%; GC/CC: %IMAT 0.6 ± 0.5% (P > 0.05). However, in the year following the training, accumulation of upper arm IMAT was twice as large in participants homozygous for the G allele (GG: Δ%IMAT +2.5 ± 0.8%; GC/CC: Δ%IMAT +1.1 ± 0.7%; P 

  14. Immunogenicity and safety of low dose virosomal adjuvanted influenza vaccine administered intradermally compared to intramuscular full dose administration

    NARCIS (Netherlands)

    Künzi, Valérie; Klap, Jaco M.; Seiberling, Michael K.; Herzog, Christian; Hartmann, Katharina; Kürsteiner, Oliver; Kompier, Ronald; Grimaldi, Roberto; Goudsmit, Jaap

    2009-01-01

    BACKGROUND: Despite the established benefit of intramuscular (i.m.) influenza vaccination, new adjuvants and delivery methods for comparable or improved immunogenicity are being explored. Intradermal (i.d.) antigen administration is hypothesized to initiate an efficient immune response at reduced

  15. Salivary testosterone in female-to-male transgender adolescents during treatment with intra-muscular injectable testosterone esters

    NARCIS (Netherlands)

    Bui, H.N.; Schagen, S.E.; Klink, D.T.; Delemarre-van de Waal, H.A.; Blankenstein, M.A.; Heijboer, A.C.

    2013-01-01

    Introduction: In our hospital, female-To-male (FtM) transgender adolescents from the age of 16 are treated with two- or four-weekly intra-muscular injections of testosterone-esters. Some patients treated with four-weekly injections have complaints of fatigue and experience mood swings towards the

  16. Intramuscular tendon involvement on MRI has limited value for predicting time to return to play following acute hamstring injury

    NARCIS (Netherlands)

    van der Made, Anne D.; Almusa, Emad; Whiteley, Rod; Hamilton, Bruce; Eirale, Cristiano; van Hellemondt, Frank; Tol, Johannes L.

    2018-01-01

    Background Hamstring injury with intramuscular tendon involvement is regarded as a serious injury with a delay in return to play (RTP) of more than 50 days and reinjury rates up to 63%. However, this reputation is based on retrospective case series with high risk of bias. Objective Determine whether

  17. 18F-FDG PET/CT Findings Following Repeated Intramuscular Injections of "Site Enhancement Oil" in the Upper Extremities

    DEFF Research Database (Denmark)

    Dejanović, Danijela; Loft, Annika

    2017-01-01

    We present the findings on F-FDG PET/CT in a 50-year-old man known to self-administer intramuscular injections with site enhancement oil in the upper extremities. PET images show diffuse pathological high FDG uptake in soft tissue of the upper arms and in scanned portions of the forearms. On the CT...

  18. The Effect of the Timing of Intramuscular Oxytocin Injection on Maternal Bleeding during the Third Stage of Labour

    Directory of Open Access Journals (Sweden)

    Sakine Mohamadian

    2013-12-01

    Full Text Available Background and aim: The third stage of labour is one of the most troublesome stages of child delivery. The basic principle of the third stage management is administrating prophylactic uterotonics. However, the time of its administration varies in different hospitals. This study aimed to determine the effect of intramuscular oxytocin injection after emergence of the fetal anterior shoulder or placental expulsion on bleeding in the third stage of labour. Methodology: This clinical trial was conducted on 100 pregnant women with gestational age of 38-42 weeks, and singleton pregnancies. Subjects were selected using convenience sampling and were then randomly assigned to intervention (injection of 10 IU intramuscular oxytocin after emergence of the fetal anterior shoulder and control (injection of 10 IU intramuscular oxytocin after placental expulsion groups. Blood was collected in containers and weighed with a weighing scale.  A checklist was used to record labor and delivery related data. Data were analyzed by SPSS version 11.5, using Chi-square and t-test. Findings: The mean amount of bleeding during the third stage of labour was 183.4 ± 145.8 and 202.2 ±208.8 ml in intervention and control group, respectively. No significant difference was found between two groups in terms of maternal bleeding. Conclusion: Injection of intramuscular oxytocin either after emergence of the fetal anterior shoulder or placental expulsion does not affect the amount of maternal bleeding during the third stage of labour.

  19. Orientação de enfermagem: fator importante no ajustamento das mulheres mastectomizadas - contribuição à assistência de enfermagem

    Directory of Open Access Journals (Sweden)

    Zuila Maria de Figueiredo Carvalho

    1984-12-01

    Full Text Available Os problemas biopsicossócio-espirituais decorrentes da mutilação por mastec-tomia constituem motivo de preocupação para os profissionais de saúde, mais precisamente da enfermeira. O objetivo deste estudo foi identificar os problemas que interferem na adaptação familiar e social da cliente, antes e após a cirurgia. Esta pesquisa, exploratória, realizou-se em dois hospitais de oncologia da Cidade do Rio de Janeiro, envolvendo sessenta clientes com câncer de mama. A amostra constitui-se de três grupos, com vinte clientes cada um. A coleta dos dados efetuou-se mediante entrevista individual. Os resultados indicam a falta de orientação nos períodos pré e pós-operatórios, assim como problemas emocionais decorrentes da mutilação que afetam especialmente a vida sexual. O trabalho oferece subsídios para o planejamento de ações de enfermagem, visando o atendimento das necessidades apresentadas por essa clientela.

  20. Intramuscular olanzapine versus intramuscular haloperidol plus lorazepam for the treatment of acute schizophrenia with agitation: An open-label, randomized controlled trial.

    Science.gov (United States)

    Huang, Charles Lung-Cheng; Hwang, Tzung-Jeng; Chen, Yi-Hsing; Huang, Guan-Hua; Hsieh, Ming H; Chen, Hsiu-Hsi; Hwu, Hai-Gwo

    2015-05-01

    To compare the efficacy and safety profile between intramuscular (IM) olanzapine and IM haloperidol plus IM lorazepam in acute schizophrenic patients with moderate to severe agitation. This was a prospective, randomized, open-label study. Acutely agitated patients with schizophrenia or schizoaffective disorder (n = 67) were randomized to receive 10 mg IM olanzapine (n = 37) or 5 mg IM haloperidol plus 2 mg IM lorazepam (n = 30). Agitation was measured with Positive and Negative Syndrome Scale Excited Component (PANSS-EC) and Agitation-Calmness Evaluation Scale (ACES) during the first 2 hours and at 24 hours after the first injection. Safety was assessed using the Simpson-Angus Scale and Barnes Akathisia Rating Scale and by recording adverse events at 24 hours following the first injection. The Clinical Global Impression-Severity scale was also rated. The PANSS-EC scores decreased significantly at 2 hours after the first injection in both groups (olanzapine: -10.2, p haloperidol + lorazepam: -9.9, p Haloperidol plus lorazepam was not inferior to olanzapine in reducing agitation at 2 hours. There were no significant differences in PANSS-EC or ACES scores between the two groups within 2 hours following the first injection. The frequencies of adverse events and changes in Clinical Global Impression-Severity, Simpson-Angus Scale, and Barnes Akathisia Rating Scale scores from baseline to 24 hours showed no significant differences between the groups. The findings suggest that IM haloperidol (5 mg) plus lorazepam (2 mg) is not inferior to IM olanzapine (10 mg) in the treatment of acute schizophrenic patients with moderate to severe agitation (ClinialTrials.gov identifier number NCT00797277). Copyright © 2015. Published by Elsevier B.V.

  1. Effectiveness of Per Rectal Misoprostol Versus Intramuscular Oxytocin for Prevention of Primary Postpartum Haemorrhage.

    Science.gov (United States)

    Asmat, Raheela; Ashraf, Tasneem; Asmat, Fazila; Asmat, Shakila; Asmat, Nagina

    2017-01-01

    To compare the effectiveness of per rectal misoprostol over oxytocin in primary postpartum haemorrhage (PPH). Randomised controlled trial study. Gynaecology and Obstetrics Department, Unit IV, Bolan Medical Complex Hospital, Quetta, from September 2013 to February 2014. Emergency obstetric patients receiving per rectal misoprostol (800 µgm) were named as group 'A' and those receiving 10 units oxytocin intramuscularly were labelled as group 'B'. The patients were followed within 24 hours of spontaneous vaginal deliveries. Pads soaked were used to assess the amount of blood loss. A total of 1,678 patients were included in the study. The mean age of patients in group-A was 29.11 years while the mean age of patients in group-B was 29.16 years. One hundred and twenty-three (14.66%) patients in group-A and 120 (14.31%) patients in group-B had PPH. Among the total 1,678 patients, 243 (14.49%) had postpartum haemorrhage among whom 24 (9.88%) had major haemorrhage with a blood loss ≥1000 mL. Among the sub-group (839 patients) administered misoprostol had 123 (14.66%) patients with blood loss greater than 500 mL and the rest 716 patients (85.34%) had blood loss less than 500 mL. The sub-group administered oxytocin have 120 (14.31%) out of 839 patients with postpartum haemorrhage while 719 (85.69%) had blood loss less than 500 mL. Active management of 3rd stage of labour with per rectal misoprostol administration was as effective as intramuscular oxytocin. Both were equally effective to reduce PPH and the subsequent need for surgical interventions.

  2. Onset and Effect Duration of Intrabuccal Space and Intramuscular Ketamine in Pediatrics

    Directory of Open Access Journals (Sweden)

    Saeed Majidi

    2018-01-01

    Full Text Available Background: Painful diagnostic and therapeutic procedures performed for children are routine actions. Opioids and nonsteroidal anti-inflammatory drugs such as acetaminophens are among medications that can be used for this purpose. This study aimed to compare the onset and duration of action of intrabuccal (IB, submucosal space and intramuscular (IM injection of ketamine in pediatrics. Materials and Methods: This clinical trial study was carried out on 126 children of 1–15 years old referred to the emergency room of Al-Zahra and Kashani Hospitals in Isfahan and divided into two 63 populated groups of IM and IB. For one group randomly, 3 mg/kg IB ketamine was administered, and for another group, ketamine was injected intramuscularly at the dose of 5 mg/kg. The drug effect, surgeon satisfaction, and complications were evaluated. Data were analyzed using SPSS software. Results: The mean of time between injection and onset of drug effect in IM group was 5.71 min, whereas in IB group, it was 4.14 min (P < 0.0001. The mean of the duration of drug effect in IM group was 45.54 min, whereas in IB group, it was 24.63 min (P < 0.0001. Complications in IM group were significantly more reported than IB group (33.3% versus 11.1%, respectively, P = 003. The median of surgeon satisfaction in IM group was 3 and in IB group was 4 which was statistically significant (P = 0.007. Conclusions: IB method is preferred over IM method, and hence, it is recommended to use.

  3. Pharmacokinetic study of flunixin and its interaction with enrofloxacin after intramuscular administration in calves

    Directory of Open Access Journals (Sweden)

    K. Abo-EL-Sooud

    Full Text Available The Pharmacokinetic aspects of flunixin (FL administered alone and in combination with enrofloxacin (EN, were studied in clinically healthy calves. The experiments were performed on two groups: FL alone {2.2 mg/kg,intramuscular (IM}, and combination of FL (2.2 mg/kg, IM and EN {2.5 mg/kg, IM}. Plasma concentrations of FL were determined using High Performance Liquid Chromatography (HPLC method. Moreover, the effects of FL alone or in combination on liver and kidney functions were also assessed. Flunixin was rapidly absorbed intramuscularly with a half-life of absorption (t of 0.094 h and the peak plasma concentration (C was 1.27 g/mL was attained after 1/2ab max 0.49 h (T . Enrofloxacin significantly altered the pharmacokinetics of FL by delaying its absorption and accelerate its max elimination from body. Significant increases (32% in the area under the curve (AUC and (37% in the elimination rate constant (K from the central compartment and a significant decrease (27% in the elimination half-life (t of FL el 1/2el were found following coadministration with EN, compared with administration of FL alone. The maximum plasma drug concentration (C showed significant increase (28% following the coadministration of EN with FL as max compared to that following the administration of FL alone. It was concluded that the combination of FL and EN negatively altered the kinetics of FL and exaggerated the adverse effect on hepato-renal function in calves consequently; the concomitant use of FL and EN should be avoided in calves. [Vet. World 2011; 4(10.000: 449-454

  4. Influence of intramuscular granisetron on experimentally induced muscle pain by acidic saline.

    Science.gov (United States)

    Louca, S; Ernberg, M; Christidis, N

    2013-06-01

    The aim of this study was to investigate whether intramuscular administration of the 5-HT(3) receptor antagonist granisetron reduces experimental muscle pain induced by repeated intramuscular injections of acidic saline into the masseter muscles. Twenty-eight healthy and pain-free volunteers, fourteen women and fourteen men participated in this randomized, double-blind and placebo-controlled study. After a screening examination and registration of the baseline pressure-pain threshold (PPT), the first simultaneous bilateral injections of 0·5 mL acidic saline (9 mg mL(-1) , pH 3·3) into the masseter muscles were performed. Two days later, PPT and pain (VAS) were re-assessed. The masseter muscle was then pre-treated with 0·5 mL granisetron (Kytril(®) 1 mg mL(-1) pH 5·3) on one side and control substance (isotonic saline, 9 mg mL(-1) pH 6) on the contralateral side. Two minutes thereafter a bilateral simultaneous injection of 0·5 mL acidic saline followed. The evoked pain intensity, pain duration, pain area and PPT were assessed. The volunteers returned 1 week later to re-assess VAS and PPT. On the side pre-treated with granisetron, the induced pain had significantly lower intensity and shorter duration (P granisetron on pain duration was significant only in women (P granisetron has a pain-reducing effect on experimentally induced muscle pain by repeated acidic saline injection. © 2013 John Wiley & Sons Ltd.

  5. In-vitro and in-vivo evaluation of diclofenac sodium intramuscular injection using gamma scintigraphy

    International Nuclear Information System (INIS)

    Soni, S.; Kumar, N.; Mehra, L.; Singh, T.; Mittal, G.; Nishad, D.K.; Sharma, B.G.; Bhatnagar, A.

    2010-01-01

    Full text: Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) which is available as over-the-counter (OTC) medication for the systemic and topical treatment of painful and inflammatory conditions such as arthritis and back pain. This study was undertaken to investigate the distribution and retention of intramuscularly injected diclofenac sodium (DFN) in white New Zealand rabbit using gamma scintigraphy. A new formulation of the nonselective NSAID diclofenac sodium suitable for intramuscular injection has been developed using sesame oil as a vehicle. The hypothesis of present work is to maintain effective concentration of DFN in blood for prolonged time period. A novel method of radiolabeling with 99m Tc-pertechnetate was adopted using stannous ions as reducing agent. The radiolabeled product was tested for quality control using ascending instant thin layer chromatography (ITLC) technique. ITLC-SG, (Gelman, USA) and acetone were used as the stationary phase and mobile phase respectively in the chromatographic procedure. In vitro and in vivo stability parameters were evaluated. Biodistribution studies and blood kinetics of 99m Tc-DFN was done in balb c mice and white New Zealand rabbit respectively. 99m Tc-DFN retention at depot site was evaluated using gamma scintigraphy. 99m Tc-DFN, when incubated at 37 deg C for 24 hr in normal saline and human serum showed disintegration of only 6.6% and 3.5% respectively, thereby indicating high stability of radiolabeled product. Protein binding studies of 99m Tc-DFN shows more than 85% serum protein binding. Blood clearance of radiopharmaceutical in rabbits, exhibited a biphasic exponential pattern in i.v. bolus while in i.m. linear control release pattern were observed up to 24 hrs

  6. Intramuscular Immunisation with Chlamydial Proteins Induces Chlamydia trachomatis Specific Ocular Antibodies.

    Directory of Open Access Journals (Sweden)

    Alexander Badamchi-Zadeh

    Full Text Available Ocular infection with Chlamydia trachomatis can cause trachoma, which is the leading cause of blindness due to infection worldwide. Despite the large-scale implementation of trachoma control programmes in the majority of countries where trachoma is endemic, there remains a need for a vaccine. Since C. trachomatis infects the conjunctival epithelium and stimulates an immune response in the associated lymphoid tissue, vaccine regimens that enhance local antibody responses could be advantageous. In experimental infections of non-human primates (NHPs, antibody specificity to C. trachomatis antigens was found to change over the course of ocular infection. The appearance of major outer membrane protein (MOMP specific antibodies correlated with a reduction in ocular chlamydial burden, while subsequent generation of antibodies specific for PmpD and Pgp3 correlated with C. trachomatis eradication.We used a range of heterologous prime-boost vaccinations with DNA, Adenovirus, modified vaccinia Ankara (MVA and protein vaccines based on the major outer membrane protein (MOMP as an antigen, and investigated the effect of vaccine route, antigen and regimen on the induction of anti-chlamydial antibodies detectable in the ocular lavage fluid of mice.Three intramuscular vaccinations with recombinant protein adjuvanted with MF59 induced significantly greater levels of anti-MOMP ocular antibodies than the other regimens tested. Intranasal delivery of vaccines induced less IgG antibody in the eye than intramuscular delivery. The inclusion of the antigens PmpD and Pgp3, singly or in combination, induced ocular antigen-specific IgG antibodies, although the anti-PmpD antibody response was consistently lower and attenuated by combination with other antigens.If translatable to NHPs and/or humans, this investigation of the murine C. trachomatis specific ocular antibody response following vaccination provides a potential mouse model for the rapid and high throughput

  7. Comparison of artemisinin suppositories, intramuscular artesunate and intravenous quinine for the treatment of severe childhood malaria.

    Science.gov (United States)

    Cao, X T; Bethell, D B; Pham, T P; Ta, T T; Tran, T N; Nguyen, T T; Pham, T T; Nguyen, T T; Day, N P; White, N J

    1997-01-01

    Severe malaria remains a major cause of mortality and morbidity for children living in many tropical regions. With the emergence of strains of Plasmodium falciparum resistant to both chloroquine and quinine, alternative antimalarial agents are required. The artemisinin group of compounds are rapidly effective in severe disease when given by intramuscular or intravenous injection. However, these routes of administration are not always available in rural areas. In an open, randomized comparison 109 Vietnamese children, aged between 3 months and 14 years, with severe P.falciparum malaria, were allocated at random to receive artemisinin suppositories followed by mefloquine (n = 37), intramuscular artesunate followed by mefloquine (n = 37), or intravenous quinine followed by pyrimethamine/sulfadoxine (n = 35). There were 9 deaths: 2 artemisinin, 4 artesunate and 5 quinine-treated children. There was no difference in fever clearance time, coma recovery, or length of hospital stay among the 3 groups. However, parasite clearance times were significantly faster in artemisinin and artesunate-treated patients than in those who received quinine (P children receiving these drugs had lower peripheral reticulocyte counts by day 5 of treatment than those in the quinine group (P = 0.011). No other adverse effect or toxicity was found. There was no treatment failure in these 2 groups, but 4 patients in the quinine group failed to clear their parasites within 7 d of starting treatment and required alternative antimalarial therapy. Artemisinin suppositories are easy to administer, cheap, and very effective for treating children with severe malaria. In rural areas where medical facilities are lacking these drugs will allow antimalarial therapy to be instituted earlier in the course of the disease and may therefore save lives.

  8. Field study on the safety and efficacy of intradermal versus intramuscular vaccination against Mycoplasma hyopneumoniae.

    Science.gov (United States)

    Beffort, Lisa; Weiß, Christine; Fiebig, Kerstin; Jolie, Rika; Ritzmann, Mathias; Eddicks, Matthias

    2017-09-30

    The present study compares the safety and efficacy of a needle-free, intradermal Mycoplasma hyopneumoniae vaccine to an intramuscular one. 420 piglets (21+3 days of age) were randomly assigned to two vaccination groups (intradermal vaccination V1 (n=138), intramuscular vaccination V2 (n=144)) and one unvaccinated control group (CG, n=138). As safety parameters clinical observations, local injection site reactions (ISR) and rectal temperatures were assessed. Average daily weight gain (ADWG) and pneumonic lung lesions (LL) were measured as efficacy parameters. ISRs were minor in V1. After both vaccinations, no adverse impact on appetite was observed and mean rectal temperatures remained within physiological range. ADWG during the fattening period was significantly higher in vaccinated groups (V1: 913.4 g, V2: 924.5 g) compared with CG (875.6 g). No differences in ADWG were observed between V1 and V2. Vaccinated pigs had a significantly reduced mean extent of LL compared with CG. V1 was superior in reducing the extent and prevalence of LL compared with V2. These results reveal that a needle-free intradermal vaccination is safe and efficacious in reducing both the prevalence and extent of lung lesions, as well as in improving performance parameters, in a farrow-to-finish farm with a late onset of M hyopneumonia e infection. © British Veterinary Association (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  9. Intramuscular leukemic relapse: clinical signs and imaging findings. A multicentric analysis

    Energy Technology Data Exchange (ETDEWEB)

    Surov, Alexey [Martin Luther University Halle-Wittenberg, Department of Radiology, Halle (Germany); University of Leipzig, Department of Diagnostic and Interventional Radiology, Leipzig (Germany); Kiratli, Hayyam [Hacettepe University School of Medicine, Department of Ophthalmology, Ankara (Turkey); Im, Soo Ah [Seoul St. Mary' s Hospital, Department of Radiology, Seoul (Korea, Republic of); Manabe, Yasuhiro [National Hospital Organization Okayama Medical Center, Department of Neurology, Okayama (Japan); O' Neill, Alibhe; Shinagare, Atul B. [Brigham and Women' s Hospital, Department of Radiology, Boston, MA (United States); Spielmann, Rolf Peter [Martin Luther University Halle-Wittenberg, Department of Radiology, Halle (Germany)

    2014-09-26

    Leukemia is a group of malignant diseases involving peripheral blood and bone marrow. Extramedullary tumor manifestation in leukemia can also occur. They more often involve lymph nodes, skin, and bones. Intramuscular leukemic relapse (ILR) is very unusual. The aim of this analysis was to summarize the reported data regarding clinical signs and radiological features of ILR. The PubMed database was searched for publications related to ILR. After an analysis of all identified articles, 20 publications matched the inclusion criteria. The authors of the 20 publications were contacted and provided imaging of their cases for review. The following were recorded: age, gender, primary diagnosis, clinical signs, pattern, localization and size of the intramuscular leukemic relapse. Images of 16 patients were provided [8 computer tomographic (CT) images and 15 magnetic resonance images, MRI]. Furthermore, one patient with ILR was identified in our institutional database. Therefore, images of 17 patients were available for further analysis. Overall, 32 cases with ILR were included in the analysis. In most cases acute myeloid leukemia was diagnosed. Most ILRs were localized in the extremities (44 %) and in the extraocular muscles (44 %). Clinically, ILR manifested as local pain, swelling and muscle weakness. Radiologically, ILR presented most frequently with diffuse muscle infiltration. On postcontrast CT/MRI, most lesions demonstrated homogeneous enhancement. ILRs were hypo-/isointense on T1w and hyperintense on T2w images. ILR manifests commonly as focal pain, swelling and muscle weakness. ILR predominantly involved the extraocular musculature and the extremities. Radiologically, diffuse muscle infiltration was the most common imaging finding. (orig.)

  10. UM CRISTIANISMO INÉDITO?

    Directory of Open Access Journals (Sweden)

    Mario de França Miranda

    2008-01-01

    Full Text Available Numa primeira parte este artigo oferece aos leitores uma síntese da obra de Charles Taylor intitulada “A era secular”, fiel à seqüência das partes do livro expostas pelo autor e ressaltando o que nos pareceu mais digno de nota. Numa segunda parte apresentamos uma reação pessoal à leitura desta importante obra. Aí aparece como as reflexões de Taylor incidem fortemente em algumas áreas da teologia e questionam seriamente o cristianismo convencional. ABSTRACT: The article’s first part offers to the readers a synthesis of Charles Taylor’s  ”A secular” era” according to the book’s topics presented by the author highlighting what is important to note. In the second part we introduce a personal response to this important work. There appears how Taylor’s reflections strongly involve some areas of Theology and raise serious questions about the conventional Christianity.

  11. MAT2B promotes adipogenesis by modulating SAMe levels and activating AKT/ERK pathway during porcine intramuscular preadipocyte differentiation

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Cunzhen; Chen, Xiaochang; Wu, Wenjing; Wang, Wusu; Pang, Weijun; Yang, Gongshe, E-mail: gsyang999@hotmail.com

    2016-05-15

    Intramuscular fat (IMF) has been demonstrated as one of the crucial factors of livestock meat quality. The MAT2B protein with MAT2α catalyzes the formation of methyl donor S- adenosylmethionine (SAMe) to mediate cell metabolism including proliferation and apoptosis. However, the regulatory effect of MAT2B on IMF deposition is still unclear. In this study, the effect of MAT2B on adipogenesis and its potential mechanism during porcine intramuscular preadipocyte differentiation was studied. The results showed that overexpression of MAT2B promoted adipogenesis and significantly up-regulated the mRNA and protein levels of adipogenic marker genes including FASN, PPARγ and aP2, consistently, knockdown of MAT2B inhibited lipid accumulation and down-regulated the mRNA and protein levels of the above genes. Furthermore, flow cytometry and EdU-labeling assay indicated that MAT2B regulate adipogenesis was partly due to influence intracellular SAMe levels and further affect cell clonal expansion. Also, increased expression of MAT2B activated the phosphorylations of AKT and ERK1/2, whereas knockdown of MAT2B blocked AKT signaling and repressed the phosphorylation of ERK1/2. Moreover, the inhibitory effect of LY294002 (a specific PI3K inhibitor) on the activities of AKT and ERK1/2 was partially recovered by overexpression of MAT2B in porcine intramuscular adipocytes. Finally, Co-IP experiments showed that MAT2B can directly interact with AKT. Taken together, our findings suggested that MAT2B acted as a positive regulator through modifying SAMe levels as well as activating AKT/ERK signaling pathway to promote porcine intramuscular adipocyte differentiation. - Highlights: • MAT2B up-regulates the expression of adipogenic marker genes and promotes porcine intramuscular preadipocyte differentiation. • MAT2B influences intracellular SAMe levels and further affects cell clonal expansion. • MAT2B interacts with AKT and activates AKT/ERK signaling pathway.

  12. Repeated maternal intramuscular or intraamniotic erythromycin incompletely resolves intrauterine Ureaplasma parvum infection in a sheep model of pregnancy.

    Science.gov (United States)

    Kemp, Matthew W; Miura, Yuichiro; Payne, Matthew S; Watts, Rory; Megharaj, Smruthi; Jobe, Alan H; Kallapur, Suhas G; Saito, Masatoshi; Spiller, O Brad; Keelan, Jeffrey A; Newnham, John P

    2014-08-01

    Ureaplasma spp are the most commonly isolated microorganisms in association with preterm birth. Maternal erythromycin administration is a standard treatment for preterm prelabor rupture of membranes. There is little evidence of its effectiveness in eradicating Ureaplasma spp from the intrauterine cavity and fetus. We used a sheep model of intrauterine Ureaplasma spp infection to investigate the efficacy of repeated maternal intramuscular and intraamniotic erythromycin treatment to eradicate such an infection. Thirty ewes with singleton pregnancies received an intraamniotic injection of 10(7) color change units of erythromycin-sensitive Ureaplasma parvum serovar 3 at 55 days' gestation. At 116 days' gestation, 28 ewes with viable fetuses were randomized to receive (1) intraamniotic and maternal intramuscular saline solution treatment (n = 8), (2) single intraamniotic and repeated maternal intramuscular erythromycin treatment (n = 10), or (3) single maternal intramuscular and repeated intraamniotic erythromycin treatment (n = 10). Fetuses were surgically delivered at 125 days' gestation. Treatment efficacy was assessed by culture, quantitative polymerase chain reaction, and histopathologic evaluation. Animals treated with intraamniotic erythromycin had significantly less viable U parvum serovar 3 in the amniotic fluid at delivery. However, neither combination of maternal intramuscular and intraamniotic erythromycin treatment successfully cleared U parvum serovar 3 from the amniotic fluid or fetal tissues. Three de novo erythromycin-resistant U parvum isolates were identified in erythromycin-treated animals. Erythromycin treatment, given both to the ewe and into the amniotic cavity, fails to eradicate intrauterine and fetal U parvum serovar 3 infection and may lead to development of erythromycin resistant U parvum. Copyright © 2014 Mosby, Inc. All rights reserved.

  13. O INSTITUTO DO INQUÉRITO CIVIL VISTO COMO FORMA E MEIO IMPORTANTE PARA PACIFICAR AS DEMANDAS COLETIVAS E A DISCUSSÃO DE SEU DEVIDO PROCESSO CONSTITUCIONAL

    Directory of Open Access Journals (Sweden)

    Francisco das Chagas da Silva

    2017-06-01

    Full Text Available O objetivo deste trabalho é abordar as peculiaridades do inquérito civil no direito brasileiro sob a ótica dos princípios que embasam o devido processo legal. Introduzido pela lei da Ação Civil Pública, o Inquérito Civil é um instituto de titularidade do Ministério Público voltado a auxiliar a pacificação dos conflitos coletivos, servindo de fundamento para a propositura de ações coletivas e de firmação do termo de ajustamento de conduta (TAC, mecanismos processuais e extraprocessuais que tem como finalidade a defesa de interesses difusos, coletivos e individuais homogêneos. Durante todo o desenvolvimento desta pesquisa foram analisadas diversas obras literárias dos mais variados autores da área do direito processual civil, do direito processual do trabalho e do direito constitucional, além da apreciação de dados oriundos da jurisprudência pátria, bem como revistas e periódicos da área jurídica pertinentes ao tema aqui desenvolvido. O trabalho está dividido numa apreciação sobre o devido processo constitucional e nos princípios norteadores do processo. Depois será desenvolvida uma análise acerca da natureza jurídica do inquérito civil e, por fim, uma discussão acerca do contraditório nesse procedimento administrativo, verificando as argumentações doutrinárias que negam a aplicação deste princípio.

  14. Condições hídricas e crescimento vegetal de culturas agrícolas importantes para comunidades indígenas do semiárido brasileiro

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    Francimar da Silva Albuquerque

    Full Text Available RESUMO A região semiárida brasileira caracteriza-se pela extrema variabilidade interanual da precipitação pluvial, de tal forma que o conhecimento do início e do fim da estação chuvosa contribui para evitar cultivos de lavouras antieconômicos e consequentes prejuízos. Objetivou-se com este trabalho relacionar as estimativas das condições hídricas com a estação de crescimento e com o desenvolvimento de culturas agrícolas importantes para as comunidades indígenas do semiárido nordestino, considerando-se três distintos cenários climatológicos. As estimativas da evapotranspiração potencial (ETP mensal, para cada localidade, foram calculadas pelo método de Thornthwaite (1948 e transformadas em médias decendiais. As variáveis distribuição decendial da precipitação, ETP integral e metade da ETP foram utilizadas para caracterização da fase de crescimento do feijão-caupi, da mandioca e do milho, além da determinação dos períodos pré-úmido, úmido e pós-úmido. Na região do semiárido nordestino brasileiro, não é possível traçar um planejamento anual agrícola para cultivos de sequeiro em anos secos. Apenas para a localidade de Banzaê, BA-Quijingue, BA, nos cenários normal e chuvoso, foi possível prever épocas com menor probabilidade de risco para os cultivos, a partir da determinação do início, da duração e do final de cada subperíodo, bem como da estação de crescimento de cada cultura, que são 31/01 a 23/09 e 10/12 a 12/09 para o feijão-caupi, 31/01 a 01/11 e 10/12 a 21/10 para a mandioca, e 31/01 a 03/10 e 10/12 a 22/09 para o milho, na mesma ordem dos cenários de precipitação. Há uma grande variabilidade e irregularidade de períodos de dez dias de precipitação, ao longo do ano, nas localidades estudadas.

  15. Propaganda: um romance quase perfeito

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    Rosane da Conceição Pereira

    2001-02-01

    Full Text Available Neste artigo, a publicidade é pensada como uma atividade que manifesta a representação racional de uma “realidade” suposta, embora através do apelo a fatores emocionais.  Ela constitui um verdadeiro “romance quase perfeito”, muitas vezes reelaborando as expectativas do público.  A partir da persuasão deste, o apelo emocional da retórica no texto e na imagem da propaganda obtém êxito.  A proposta é então pensar como a publicidade pode ser fundamentada na representação platônica, ainda que operada de modo contrário.

  16. La olfacción: otro componente importante del examen físico Olfaction: another important component of physical examination

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    Marco Antonio Montano Díaz

    2006-12-01

    Full Text Available Se presenta un trabajo donde se revisa la literatura disponible, y se aporta la experiencia personal de los autores sobre la utilidad de la olfacción para realizar un correcto diagnóstico clínico, así como las posibilidades técnicas con que contamos hoy para detectar y medir diversas substancias emanadas del cuerpo humano. Los objetivos propuestos son: cómo promover la idea de incluir la enseñanza organizada y sistemática de la olfacción como un componente importante del examen físico del paciente, y motivar a los tecnólogos para que produzcan y desarrollen instrumentos con los fines expresados. La literatura y la práctica diaria demuestran la abundante y útil información que brinda la olfacción bien realizada. Se expone lo referido sobre la olfacción por varios clásicos de la medicina y por jóvenes especialistas de nuestro tiempo y se concluye que la olfacción debe incluirse junto con la inspección, palpación, percusión y auscultación como otro elemento del examen físico que debe ser enseñado sistemáticamente en nuestras universidades, así como la conveniencia de desarrollar una tecnología que permita detectar substancias volátiles en el aliento y otras emanaciones humanas. No se trata aquí de la utilidad de los olores con fines terapéuticos o de otro tipo que no sea diagnóstico.A study where available medical literature is revised and personal experience of the authors about the usefulness of olfaction is taken in order to carry out a proper clinical diagnosis, as well as the technical possibilities in present days to detect and measure several substances that emanate from the human body. The objectives proposed are: the promotion of the idea to include an organized and systematic teaching of olfaction as an important component of physical examination in patients, and to encourage the technologists to produce and develop instruments with this purpose. Medical literature and daily practice show the abundant and

  17. C8. Um caso singular de tuberculose

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    Carlos Lopes

    2003-11-01

    Full Text Available Doente sexo masculino, 50 anos, raça negra, HIV -, fumador, hábitos etílicos importantes, baixo nível sócio-económico. Internado por quadro com dois meses de evolução de: febre, suores nocturnos, tosse, expectoração, emagrecimento (20 Kg/3 M, anorexia, astenia, seguido por: náuseas, vómitos, distensão e dor abdominais. O exame objectivo revelou: fervores na auscultação pulmonar e hepatomegália. Raio-X Tórax: infiltrado alvéolointersticial difuso bilateral. Ecografia abdominal: hepatomegália e ascite. Paracentese: ascite quilosa; pleocitose linfocítica; teste cutâneo de tuberculina +. Exame bacteriológico da expectoração: M. tuberculosis. Parâmetros inflamatórios de fase aguda aumentados; TC Torácica: consolidação do lobo superior direito; opacidades nodulares bilaterais, derrame pleural esquerdo, liquído intraperitoneal; hepatomegália heterogénea; infiltração da gordura mesentérica e espessamento parietal.Durante o internamento, iniciou diarreia e dor abdominal intensa. A colonoscopia revelou estenose parcial do íleon terminal, processo inflamatório; úlceras da sigmóideia. Histologia: infiltrado inflamatório linfocítico e granulomas epitelióides com células gigantes multinucleadas. Alguns bacilos álcool-ácido resistentes (ZN.Foi administrada terapêutica quádrupla (HRZE desde o 2.º dia de internamento. Ao 47.º dia de internamento, verificou-se um agravamento da dor abdominal. Diagnóstico final: Tuberculose Pulmonar, Gastrointestinal e Peritoneal.Actualmente, o envolvimento do tracto gastrointestinal e peritoneu é raro, geralmente resultante de disseminação hematogénea. : Male patient, 50 years old, african, HIV ˜, smoker, heavy etanolic habits, low socioeconomic status. He was admitted to our department due to fever, night sweats, cough, sputum, weight loss (20Kg/ 3 M, anorexia

  18. Resultados do desenvolvimento de um propulsor à plasma no Brasil

    Science.gov (United States)

    Ferreira, I. S.; Ferreira, J. L.

    2003-08-01

    Uma das partes mais importantes de um satélite é o controle de atitude do mesmo. E se tratando de um satélite científico, a atenção para este sistema deve ser redobrada. Uma possibilidade atraente para executar esta tarefa é a propulsão elétrica. Aqui, mostraremos resultados obtidos pelo propulsor à plasma PHALL-01, desenvolvido na Universidade de Brasília entre 2000 e 2003. Este é derivado do propulsor russo SPT-100 (Stationary Plasma Thruster), mas com o emprego inovador de um arranjo de imãs permanentes como fonte do campo magnético, este último o agente da aceleração do plasma. Esta alteração foi motivada pelo objetivo de que o mesmo operasse com o mínimo de potência elétrica. A partir da formulação teórica do mecanismo de aceleração, tendo como base as equações da magnetohidrodinâmica, pode-se obter vínculos sob os quais o propulsor pudesse ser construído. O mais forte destes é o que dita a topologia do campo magnético. Sendo assim, foram realizadas simulações computacionais, que definiram a geometria do propulsor. Após construído, este foi diagnosticado usando-se sondas de Langmuir e analisadores de energia. Como resultados, obtivemos a distribuição espacial da temperatura, densidade e potencial do plasma, bem como a distribuição angular do feixe produzido pelo mesmo em vários regimes de operação. O espectro de energia do feixe de plasma também foi medido, indicando íons de até 560eV. Combinando estes resultados, calculou-se o empuxo do propulsor: 84mN; e o impulso específico: 1083s. Estes demonstram que o mesmo estará qualificado, num futuro próximo, para o emprego no controle de atitude de satélites científicos, ou até mesmo como parte do conjunto propulsor primário, responsáveis pela transferência de órbitas.

  19. Bloqueio do nervo supraescapular: procedimento importante na prática clínica. Parte II Suprascapular nerve block: important procedure in clinical practice. Part II

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    Marcos Rassi Fernandes

    2012-08-01

    Full Text Available O bloqueio do nervo supraescapular é um método de tratamento reprodutível, confiável e extremamente efetivo no controle da dor no ombro. Esse método tem sido amplamente utilizado por profissionais na prática clínica, como reumatologistas, ortopedistas, neurologistas e especialistas em dor, na terapêutica de enfermidades crônicas, como lesão irreparável do manguito rotador, artrite reumatoide, sequelas de AVC e capsulite adesiva, o que justifica a presente revisão (Parte II. O objetivo deste estudo foi descrever as técnicas do procedimento e suas complicações descritas na literatura, já que a primeira parte reportou as indicações clínicas, drogas e volumes utilizados em aplicação única ou múltipla. Apresentamse, detalhadamente, os acessos para a realização do procedimento tanto direto como indireto, anterior e posterior, lateral e medial, e superior e inferior. Diversas são as opções para se realizar o bloqueio do nervo supraescapular. Apesar de raras, as complicações podem ocorrer. Quando bem indicado, este método deve ser considerado.The suprascapular nerve block is a reproducible, reliable, and extremely effective treatment method in shoulder pain control. This method has been widely used by professionals in clinical practice such as rheumatologists, orthopedists, neurologists, and pain specialists in the treatment of chronic diseases such as irreparable rotator cuff injury, rheumatoid arthritis, stroke sequelae, and adhesive capsulitis, which justifies the present review (Part II. The objective of this study was to describe the techniques and complications of the procedure described in the literature, as the first part reported the clinical indications, drugs, and volumes used in single or multiple procedures. We present in details the accesses used in the procedure: direct and indirect, anterior and posterior, lateral and medial, upper and lower. There are several options to perform suprascapular nerve block

  20. UM OLHAR QUALITATIVO SOBRE AÇÕES PROMOCIONAIS DO SHOPPING TOTAL DA CIDADE DE PORTO ALEGRE

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    Cláudio Damacena

    2012-08-01

    Full Text Available As atitudes e os comportamentos dos consumidores em relação aos shopping centers continuam sendo tópicos importantes de pesquisa na Área de Marketing, principalmente pelo dinamismo da evolução social, econômica e tecnológica e seu impacto no mundo do consumo. Nesse contexto, percebe-se um certo paradoxo, ou seja, o número de shopping centers continua crescendo, entretanto, o número de consumidores que visitam esses empreendimentos não aumenta no mesmo ritmo. Por isso que cada vez mais ações promocionais são realizadas para atrair o consumidor ao shopping center, porém apenas algumas são eficazes. Com o objetivo de explorar essa questão, foi realizada uma pesquisa qualitativa sobre um dos shoppings de uma região metropolitana brasileira, mas especificamente sobre uma de suas ações promocionais. Os resultados do estudo apontam importantes revelações sobre as percepções de lojistas e consumidores acerca de ações promocionais realizadas por shopping centers. Um desses resultados mostra a importância do tempo e da repetição do evento para que possa ser lembrado e associado ao shopping, gerando imagem positiva à marca. Outro resultado importante é a questão da participação de todos os lojistas do shopping center, inclusive nas atividades de entretenimento, no planejamento e na realização da ação promocional. Palavras-chave: Shopping Center. Imagem. Promoção.

  1. Irinotecan-loaded double-reversible thermogel with improved antitumor efficacy without initial burst effect and toxicity for intramuscular administration.

    Science.gov (United States)

    Din, Fakhar Ud; Kim, Dong Wuk; Choi, Ju Yeon; Thapa, Raj Kumar; Mustapha, Omer; Kim, Dong Shik; Oh, Yu-Kyoung; Ku, Sae Kwang; Youn, Yu Seok; Oh, Kyung Taek; Yong, Chul Soon; Kim, Jong Oh; Choi, Han-Gon

    2017-05-01

    Intramuscularly administered, anti-tumour drugs induce severe side effects due to their direct contact with body tissues and initial burst effect. In this study, to solve this problem, a novel double-reversible thermogel system (DRTG) for the intramuscular administration of irinotecan was developed. This irinotecan-loaded DRTG was prepared by dispersing the irinotecan-loaded thermoreversible solid lipid nanoparticles (SLNs) in the thermoreversible hydrogel. In DRTG, the former was solid at 25°C but converted to liquid at 36.5°C; in contrast, the latter existed in a liquid form but transformed to gel state in the body. The DRTG was easily administered intramuscularly. Its particle size and drug content were not noticeably changeable, resulting that it was stable at 40°C for at least 6months. Compared to the irinotecan-loaded solution and conventional hydrogel, the DRTG significantly delayed drug release, leading to a reduced burst effect. Moreover, it showed decreased C max and maintained the sustained plasma concentrations at a relatively low level for the long period of 60h in rats, resulting in ameliorated side effects of the anti-tumour drug. Furthermore, it gave significantly improved anti-tumour efficacy in tumour-bearing mice compared to the hydrogel but, unlike the conventional hydrogel, induced no body weight loss and local damage to the muscle. Thus, this DRTG with improved antitumor efficacy without initial burst effect and toxicity could provide a potential pharmaceutical system for the intramuscular administration of irinotecan. Intramuscularly administered, anti-tumour drugs induce severe side effects due to their direct contact with body tissues and initial burst effect. To solve this problem, we developed a novel double-reversible thermogel system (DRTG) for the intramuscular administration of irinotecan. Unlike the conventional hydrogel, the DRTG is a dispersion of the irinotecan-loaded thermoreversible solid lipid nanoparticles in the

  2. Potentiation of electrochemotherapy by intramuscular IL-12 gene electrotransfer in murine sarcoma and carcinoma with different immunogenicity

    International Nuclear Information System (INIS)

    Sedlar, Ales; Dolinsek, Tanja; Markelc, Bostjan; Prosen, Lara; Kranjc, Simona; Bosnjak, Masa; Blagus, Tanja; Cemazar, Maja; Sersa, Gregor

    2012-01-01

    Electrochemotherapy provides good local tumor control but requires adjuvant treatment for increased local response and action on distant metastasis. In relation to this, intramuscular interleukin-12 (IL-12) gene electro-transfer, which provides systemic shedding of IL-12, was combined with local electrochemotherapy with cisplatin. Furthermore, the dependence on tumor immunogenicity and immunocompetence of the host on combined treatment response was evaluated. Sensitivity of SA-1 sarcoma and TS/A carcinoma cells to electrochemotherapy with cisplatin was tested in vitro. In vivo, intratumoral electrochemotherapy with cisplatin (day 1) was combined with a single (day 0) or multiple (days 0, 2, 4) intramuscular murine IL-12 (mIL-12) gene electrotransfer. The antitumor effectiveness of combined treatment was evaluated on immunogenic murine SA-1 sarcoma in A/J mice and moderately immunogenic murine TS/A carcinoma, in immunocompetent BALB/c and immunodeficient SCID mice. Electrochemotherapy in vitro resulted in a similar IC 50 values for both sarcoma and carcinoma cell lines. However, in vivo electrochemotherapy was more effective in the treatment of sarcoma, the more immunogenic of the tumors, resulting in a higher log cell kill, longer specific tumor growth delay, and also 17% tumor cures compared to carcinoma where no tumor cures were observed. Adjuvant intramuscular mIL-12 gene electrotransfer increased the log cell kill in both tumor models, potentiating the specific tumor growth delay by a factor of 1.8-2 and increasing tumor cure rate by approximately 20%. In sarcoma tumors, the potentiation of the response by intramuscular mIL-12 gene electrotransfer was dose-dependent and also resulted in a faster onset of tumor cures. Comparison of the carcinoma response to the combined treatment modality in immunocompetent and immunodeficient mice demonstrated that the immune system is needed both for increased cell kill and for attaining tumor cures. Based on the comparison of

  3. The neuroprotective effects of intramuscular insulin-like growth factor-I treatment in brain ischemic rats.

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    Heng-Chih Chang

    Full Text Available Brain ischemia leads to muscle inactivity-induced atrophy and may exacerbate motor function deficits. Intramuscular insulin-like growth factor I (IGF-I injection has been shown to alleviate the brain ischemia-induced muscle atrophy and thus improve the motor function. Motor function is normally gauged by the integrity and coordination of the central nervous system and peripheral muscles. Whether brain ischemic regions are adaptively changed by the intramuscular IGF-I injection is not well understood. In this study, the effect of intramuscular IGF-I injection was examined on the central nervous system of brain ischemic rats. Rats were divided into 4 groups: sham control, brain ischemia control, brain ischemia with IGF-I treatment, and brain ischemia with IGF-I plus IGF-I receptor inhibitor treatment. Brain ischemia was induced by right middle cerebral artery occlusion. IGF-I and an IGF-1 receptor inhibitor were injected into the affected calf and anterior tibialis muscles of the treated rats for 4 times. There was an interval of 2 days between each injection. Motor function was examined and measured at the 24 hours and 7 days following a brain ischemia. The affected hind-limb muscles, sciatic nerve, lumbar spinal cord, and motor cortex were collected for examination after euthanizing the rats. IGF-I expression in the central nervous system and affected muscles were significantly decreased after brain ischemia. Intramuscular IGF-I injection increased the IGF-I expression in the affected muscles, sciatic nerve, lumbar spinal cord, and motor cortex. It also increased the p-Akt expression in the affected motor cortex. Furthermore, intramuscular IGF-I injection decreased the neuronal apoptosis and improved the motor function. However, co-administration of the IGF-I receptor inhibitor eliminated these effects. Intramuscular IGF-I injection after brain ischemia attenuated or reversed the decrease of IGF-I in both central and peripheral tissues, and

  4. Health worker and policy-maker perspectives on use of intramuscular artesunate for pre-referral and definitive treatment of severe malaria at health posts in Ethiopia

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    Takele Kefyalew

    2016-10-01

    Full Text Available Abstract Background The World Health Organization (WHO recommends injectable artesunate given either intravenously or by the intramuscular route for definitive treatment for severe malaria and recommends a single intramuscular dose of intramuscular artesunate or intramuscular artemether or intramuscular quinine, in that order of preference as pre-referral treatment when definitive treatment is not possible. Where intramuscular injections are not available, children under 6 years may be administered a single dose of rectal artesunate. Although the current malaria treatment guidelines in Ethiopia recommend intra-rectal artesunate or alternatively intramuscular artemether or intramuscular quinine as pre-referral treatment for severe malaria at the health posts, there are currently no WHO prequalified suppliers of intra-rectal artesunate and when available, its use is limited to children under 6 years of age leaving a gap for the older age groups. Intramuscular artesunate is not part of the drugs recommended for pre-referral treatment in Ethiopia. This study assessed the perspectives of health workers, and policy-makers on the use of intramuscular artesunate as a pre-referral and definitive treatment for severe malaria at the health post level. Methods In-depth interviews were held with 101 individuals including health workers, malaria focal persons, and Regional Health Bureaus from Oromia and southern nations, nationalities, and peoples’ region, as well as participants from the Federal Ministry of Health and development partners. An interview guide was used in the data collection and thematic content analysis was employed for analysis. Results Key findings from this study are: (1 provision of intramuscular artesunate as pre-referral and definitive treatment for severe malaria at health posts could be lifesaving; (2 with adequate training, and provision of facilities including beds, health posts can provide definitive treatment for severe

  5. Comparison of oral itraconazole and intramuscular meglumine antimoniate in the treatment of cutaneous leishmaniasis

    International Nuclear Information System (INIS)

    Saleem, K.; Rahman, A.

    2007-01-01

    To compare the efficacy and tolerability of oral itraconazole against intramuscular meglumine antimoniate in the treatment of Cutaneous Leishmaniasis (CL). Two hundred eligible and consenting patients of Cutaneous Leishmaniasis (CL) were divided in two groups with 100 patients in each. The number and location of the lesions were documented and clinical types of cutaneous leishmaniasis were noted. The diagnosis was confirmed by skin slit smear and histopathology of the lesional skin. Culture on Nicolle Novy MacNeal (NNN) medium and Leishmanin test was done in all patients. All the patients in both groups were subjected to complete blood picture, urine examination, serum urea and creatinine levels and ECG examination. One group was given itraconazole 100 mg twice daily orally for a duration of 6-8 weeks. The other group was given meglumine antimoniate 10 cc in the form of deep intramuscular injections for 15-30 days. The efficacy of the treatment was judged by clinical and parasitological response. Side effects of the agents were also noted during treatment. Out of 200 patients studied, 185 were males and 15 were females. The mean age of presentation was 30 + 6.6 years. Single lesion was seen in 132 (66%) subjects whereas 68 (34%) subjects had multiple lesions. Slit skin smears were positive in 50 (25%) of the patients. Skin biopsy yielded the presence of LT bodies in 150 (75%) subjects. The culture was positive in 102 (51%) cases. Leishmanin test was positive in 94% subjects. Seventy-five (75%) patients on itraconazole therapy showed complete clinical and parasitological cure in 4-8 weeks duration. A rise in ALT was seen in 12% subjects. Five (5%) subjects did not show any improvement till the end of therapy. Sixty-five (65%) subjects on meglumine antimoniate showed complete healing in 15-30 days. In 35 (35%) of the patients, the treatment had to be stopped due to intolerable side-effects. Four cases of lupoid leishmaniasis and 4 cases of sporotrichoid leishmaniasis

  6. Comparison of intramuscular alfaxalone and ketamine combined with dexmedetomidine and butorphanol for castration in cats.

    Science.gov (United States)

    Khenissi, Latifa; Nikolayenkova-Topie, Olga; Broussaud, Ségolène; Touzot-Jourde, Gwenola

    2017-08-01

    Objectives Cardiorespiratory parameters and anaesthesia quality in cats anaesthetised with either intramuscular (IM) alfaxalone or ketamine both combined with dexmedetomidine and butorphanol for castration were evaluated. Methods Thirty-two client-owned cats were randomly assigned to receive either alfaxalone (A; 3 mg/kg IM) or ketamine (K; 5 mg/kg IM), combined with dexmedetomidine (10 μg/kg) and butorphanol (0.2 mg/kg). Heart rate (HR), respiratory rate (RR) and rectal temperature (T°) were recorded prior to drug administration. Pulse rate (PR) and RR were recorded 10 (T 10 ) and 15 (T 15 ) mins after injection (T 0 ). Cardiorespiratory values (PR, RR, SPO 2 , blood pressure, P E 'CO 2 ) were recorded every 5 mins for the duration of the procedure. Pain at injection, intubation and recovery were evaluated with simple descriptive scores. Feasibility of anaesthesia was evaluated by the number of top-ups of anaesthetic needed. Cat attitude, ability to walk and presence of ataxia were assessed several times after extubation (T exmin ) and the time between injection and extubation recorded. Pain was assessed at T ex120 and T ex240 with the 4Avet-pain score. Results The RR was significantly lower in group K at T 10 (RR K = 28 ±13.35 breaths per minute [brpm], RR A = 43.24 ±7.04 brpm) and T 15 (RR K = 28 ±11.53 brpm vs RR A = 43 ±12.18 brpm). Time to extubation was significantly longer in group A (T A = 62 ±14.6 mins, T K = 45.13 ± 7.38 mins). Cats in group K needed more top-ups, were more ataxic at T ex120 , had a worse recovery score at T ex60 and were less willing to walk at T ex30 . Conclusions and relevance Cats receiving alfaxalone had a longer but better quality recovery. Cardiorespiratory parameters were stable and within clinically acceptable values following IM injection of either alfaxalone or ketamine in healthy cats. Intramuscular alfaxalone is a suitable alternative to ketamine for short procedures requiring anaesthesia when used in combination

  7. Intramuscular renin-angiotensin system is activated in human muscular dystrophy.

    Science.gov (United States)

    Sun, Guilian; Haginoya, Kazuhiro; Dai, Hongmei; Chiba, Yoko; Uematsu, Mitsugu; Hino-Fukuyo, Naomi; Onuma, Akira; Iinuma, Kazuie; Tsuchiya, Shigeru

    2009-05-15

    To investigate the role of the muscular renin-angiotensin system (RAS) in human muscular dystrophy, we used immunohistochemistry and Western blotting to examine the cellular localization of angiotensin-converting enzyme (ACE), the angiotensin II type 1 receptor (AT1) and the angiotensin II type 2 receptor (AT2) in muscle biopsies from patients with Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), and congenital muscular dystrophy (CMD). In normal muscle, ACE was expressed in vascular endothelial cells and neuromuscular junctions (NMJs), whereas AT1 was immunolocalized to the smooth muscle cells of blood vessels and intramuscular nerve twigs. AT2 was immunolocalized in the smooth muscle cells of blood vessels. These findings suggest that the RAS has a functional role in peripheral nerves and NMJs. ACE and AT1, but AT2 immunoreactivity were increased markedly in dystrophic muscle as compared to controls. ACE and the AT1 were strongly expressed in the cytoplasm and nuclei of regenerating muscle fibers, fibroblasts, and in macrophages infiltrating necrotic fibers. Double immunolabeling revealed that activated fibroblasts in the endomysium and perimysium of DMD and CMD muscle were positive for ACE and AT1. Triple immunolabeling demonstrated that transforming growth factor-beta1 (TGF-beta1) and ACE were colocalized on the cytoplasm of activated fibroblasts in dystrophic muscle. Furthermore, Western blotting showed increases in the expression of AT1 and TGF-beta1 protein in dystrophic muscle, which coincided with our immunohistochemical results. The overexpression of ACE and AT1 in dystrophic muscle would likely result in the increased production of Ang II, which may act on these cells in an autocrine manner via AT1. The activation of AT1 may induce fibrous tissue formation through overexpression of TGF-beta1, which potently activates fibrogenesis and suppresses regeneration. In conclusion, our results imply that the intramuscular RAS-TGF-beta1 pathway

  8. Comparative pharmacokinetics of cefoperazone following intravenous and intramuscular administration in goats

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    Taha Attia

    2015-06-01

    Full Text Available The pharmacokinetic profile of cefoperazone was studied in goats following intravenous and intramuscular administration of 20 mg/kg body weight. Cefoperazone concentrations in serum were determined by microbiological assay technique using Escherichia coli (ATCC 10536 as test organism. Following i.v. administration, the cefoperazone serum concentration–time curve was best fitted in a two compartment open model. Cefoperazone has moderate distribution in the body of goats with Vdss of 0.44 ± 0.03 L/kg. The elimination half-life (T0.5(β, area under curve (AUC and total body clearance (Cltot were 1.97 ± 0.14 h, 149.63 ± 8.61 μg ml−1 h−1, and 2.17 ml/min/kg, respectively. Following i.m. administration, the drug was very rapidly absorbed, with an absorption half-life (T0.5(ab of 0.12 ± 0.01 h. The maximum serum concentration (Cmax of 30.42 ± 3.53 μg ml−1 was attained at (Tmax 0.58 ± 0.02 h, with an elimination half-life (T0.5(el of 2.53 ± 0.11 h. The systemic bioavailability of cefoperazone in the goats after i.m. administration was 83.62% and in vitro protein binding was 20.34%. The serum concentrations of cefoperazone along 12 h post i.m. injection in this study were exceeding the MIC of different susceptible micro-organisms responsible for serious disease problems. Consequently, a suitable intramuscular dosage regimen for cefoperazone was 20 mg/kg repeated at 12 h intervals in goats. The drug was detected in urine up to 12 and 18 h following i.v. and i.m. administration, respectively.

  9. Ecologia alimentar e conectividade genética de Chaetodon Striatus em um gradiente geográfico

    OpenAIRE

    Liedke, Ana Maria Rubini

    2013-01-01

    Resumo: Conhecer a ecologia alimentar de uma espécie é um aspecto importante para compreender sua biologia. A relação entre disponibilidade, qualidade do alimento e estado fisiológico reflete na distribuição e abundância de uma dada espécie, e terá influência direta no comportamento alimentar e tipo de presas. A relação entre plasticidade alimentar e fluxo gênico pode levar as populações das extremidades da distribuição a se diferenciarem e possivelmente se adaptarem aos recursos disponíveis....

  10. Reações dos consumidores a falhas de serviços: um estudo no Brasil e EUA

    OpenAIRE

    Matos, Celso Augusto de; Garrido, Ivan Lapuente; D’Ávila, Lívia Castro; Calixto, Cyntia Vilasboas

    2012-01-01

    Apesar das pesquisas sobre falhas e recuperação de serviços, há poucos estudos investigando o efeito de diferenças culturais. Com base na revisão da literatura, foi proposto um modelo teórico, testado em dados de uma survey realizada junto a 260 consumidores do Brasil e EUA. Os resultados mostraram que a dimensão interpessoal da justiça percebida foi a mais importante para explicar a satisfação do consumidor, que por sua vez influenciou mais fortemente a intenção de reclamar junto a amigos...

  11. Bullying na Escola: um sofrimento

    Directory of Open Access Journals (Sweden)

    Marlene Silva Sardinha Gurpilhares

    2014-07-01

    Full Text Available O bullying é uma forma de violência presente nas escolas e o termo é utilizado para caracterizar todas as formas de agressões repetitivas psicológicas e físicas, direta ou indiretamente. Esta violência causa sofrimentos, intimidação e medo, sempre numa relação de poder entre pares. Esta pesquisa trata de um estudo do bullying escolar: o que é, como surgiu, como identificá-lo e sua caracterização, conseqüências, causas, o papel da escola, de professores e pais e uma proposta prática que pode ser adotada para sua prevenção e contenção. O objetivo é organizar materiais para leitura dos atores educacionais para uma possível reflexão, através de pesquisas bibliográficas. Esta violência é grave e deveria ser tratada como saúde pública, devido às conseqüências que traz, como queda na aprendizagem, na autoestima e em casos mais graves, até o suicido e outras tragédias. A escola necessita atentar para esse tipo de violência, revendo suas ações em todos os momentos, tendo um olhar integral e diferenciado em relação aos alunos. É fundamental que o bullying não seja tratado como brincadeira de criança e para ser identificado e combatido é necessária uma ação entre a família e todos da escola, que pode ser desenvolvida através de projetos que ajudem a apontar caminhos para a solução do problema. Tais ações devem ser pautadas por constantes debates e reflexões, nas quais o aluno se torne o protagonista. Não existem fórmulas prontas, pois a intervenção deve ser feita através da realidade de cada escola.

  12. Mulher, Pampa e natureza: um olhar através de contos puebleros

    Directory of Open Access Journals (Sweden)

    Juliana Corrêa Pereira Schlee

    2016-12-01

    Full Text Available O presente trabalho é um estudo em andamento que se detém nos contos puebleros para deslocar o olhar sobre a mulher, o Pampa e a natureza. Assim, busco a Educação Ambiental, como campo de saber importante e potente para a análise de mundo que temos em seu processo de construção cultural moderno. Entendendo a literatura como pedagogia cultural para problematizar como nos constituímos mulher no Pampa e como nos relacionamos com o discurso de natureza. O Pampa para pensar além de um território geográfico, mas como um lugar que é constituído pelos diversos atravessamentos: biológicos, geográficos, culturais, econômicos, políticos. Modos de ver o mundo, viver e narrar a natureza. Fabricações  histórica e socialmente constituídos em diferentes culturas e em diferentes épocas. É preciso pensar sobre as universalidades de ser mulher, assim como suas relações com a natureza e o pampa.

  13. Desenvolvimento de um ambiente de aprendizagem para o ensino de controle de processos

    Directory of Open Access Journals (Sweden)

    André Pereira da Costa

    2014-12-01

    Full Text Available Esta pesquisa teve como objetivo construir um ambiente de aprendizagem para o ensino de Controle deProcessos, tornando-se um importante recurso didático que favorece o aprendizado dos graduandos do CursoSuperior de Tecnologia em Automação Industrial, no IFPB Campus Cajazeiras. Então, em nosso percursometodológico, utilizamos o software MATLAB, bem como sua linguagem de programação característica, paratornar viável a construção do ambiente. Tal software é bastante utilizado na área de Controle de Processos emdiversas pesquisas, contribuindo tanto para o desenvolvimento prático, pois possibilita que novos métodos decontrole sejam avaliados e empregados nas mais distintas situações, como também no campo educacional.Além disso, utilizamos os pêndulos simples e invertido como modelos mecânicos do simulador. Dentre osresultados obtidos, podemos mencionar a simplicidade de utilização e manipulação do ambiente, pois suainterface gráfica facilita a execução das simulações, de modo dinâmico, na qual o estudante de graduaçãopoderá configurar o sistema e o controlador, além de visualizar o resultado da simulação em um gráfico.

  14. Performance Esportiva ou Performance Administrativa: O Dilema dos Gestores de um Clube de Futebol Brasileiro

    Directory of Open Access Journals (Sweden)

    Renan Bonamigo Tonial

    2017-02-01

    Full Text Available O mercado esportivo mundial assume um papel importante na economia de alguns países. No Brasil, a expressiva movimentação financeira posiciona o futebol como principal esporte desse mercado. Neste contexto está inserido o Grêmio Foot-Ball Porto Alegrense, um clube de futebol profissional com sede na cidade de Porto Alegre, no estado do Rio Grande do Sul. Os gestores responsáveis pelo clube encontram-se em um dilema relacionado as escolhas estratégicas, provocado pela baixa performance esportiva e administrativa do clube. Este caso de ensino, decorrente da consolidação de dados secundários, visando proporcionar a reflexão e promover a discussão sobre temas ligados ao planejamento estratégico, escolha da estratégia competitiva, processo decisório e identificação de perfil dos agentes de tomada de decisão. Desse modo, sugere-se a aplicação do caso nos cursos de graduação e pós-graduação, nas disciplinas de administração estratégica, administração mercadológica e administração esportiva.

  15. Um novo Fundef? As idéias de Anísio Teixeira

    Directory of Open Access Journals (Sweden)

    Amaral Nelson Cardoso

    2001-01-01

    Full Text Available O professor Anísio Teixeira, na década de 1960, preocupado com o financiamento da educação, apresentou uma proposta de como definir e implantar um fundo que garantisse recursos permanentes para o ensino primário. Em seus aspectos metodológicos, o Fundo de Manutenção e Desenvolvimento do Ensino Fundamental e de Valorização do Magistério (Fundef, criado pelo Governo, assemelha-se à proposta apresentada por Anísio Teixeira. Existem, entretanto, diferenças importantes e fundamentais, pelo fato do professor Anísio definir o volume total de recursos a partir do estabelecimento do salário dos docentes. Nesse estudo apresentam-se as semelhanças e diferenças entre os dois fundos e realiza-se uma simulação do que se poderia chamar "Um novo Fundef", baseado nas idéias de Anísio Teixeira. Como resultado, obtém-se valores perfeitamente viáveis para serem financiados por uma economia com a dimensão da economia brasileira, assim como ocorreu no estudo apresentado por Anísio Teixeira no livro Educação é um direito.

  16. Um credo pedagógico na democracia escolar: algum traçado do pensamento de John Dewey = A democratic creed in school’s democracy: John Dewey’s educational thoughts

    Directory of Open Access Journals (Sweden)

    Boto, Carlota

    2006-01-01

    Full Text Available Este artigo pretende trabalhar com o pensamento pedagógico de John Dewey. Filósofo americano, Dewey viveu entre 1859 e 1952 e foi um importante líder do movimento que ficou conhecido nos Estados Unidos da América como educação progressiva. Sua obra constitui importante fonte para compreender os temas da democracia, do interesse, do ensino ativo e da liberdade em contextos educacionais. Por tal razão, suas idéias podem ser consideradas como pioneiras do que aqui compreendemos como segunda geração de direitos educacionais

  17. DEFININDO UM OPERADOR-MONSTRO

    Directory of Open Access Journals (Sweden)

    Lovania Roehrig TEIXEIRA

    2015-06-01

    Full Text Available O presente artigo revê a literatura relacionada a um tipo particular de operador, supostamente presente em línguas naturais, chamado de “operador-monstro”. Esse operador tem a característica de poder mudar o contexto de avaliação de itens indexicais sob seu escopo. Sua existência foi inicialmente negada por Kaplan (1989, em seu famoso texto sobre a semântica dos itens indexicais, e, posteriormente, autores como Schlenker (2003 e Anand (2006 argumentaram que tais operadores de fato existem em línguas naturais, com base tanto em dados de línguas indo-europeias quanto de outras famílias linguísticas. Contudo, analisando com cuidado a literatura, é possível notar, nos vários autores que se debruçaram sobre o tema, diferentes definições desse operador. Neste artigo, após apresentar o conceito de operador-monstro conforme postulado por Kaplan (1989 e defender sua existência com base em dados do português brasileiro (PB, argumentamos a favor de uma definição para esse operador que seja ampla, nas linhas daquela primeiramente proposta por Kaplan (1989. Os dados do PB serão crucias para defender nossa posição.

  18. Um tico para formar adultos

    Directory of Open Access Journals (Sweden)

    Edson Mendes de Almeida

    2017-07-01

    Full Text Available A revista Tico-Tico foi lançada em 1905, com a intenção de ensinar as crianças. Era publicada como um suplemento na revista O Malho, mas que poderia ser adquirida separadamente. Em seu interior eram encontradas histórias em quadrinhos, inicialmente decalcadas dos jornais estadunidenses e posteriormente feitas por artistas nacionais, lendas e contos, galeria de fotos dos leitores, além das seções do Dr. Sabe-tudo e das Lições do Vovô. A publicação procurou desenvolver o hábito de leitura e gosto pelo conhecimento dos pequenos, que até então não tinham uma obra voltada para eles. O período estudado do periódico (1920-1922, perfaz outro movimento singular na época, o desenvolvimento da Semana de Arte Moderna de 1922, em São Paulo.

  19. Corpo & Gênero: Articulando Um Debate

    Directory of Open Access Journals (Sweden)

    Carla Cristina Lima de Almeida

    2012-04-01

    Full Text Available

      O artigo examina as relações entre corpo e gênero, problematizando a tese de que o corpo constitui uma base fixa sobre a qual se fundamenta o gênero. A partir de um estudo bibliográfico, apresenta argumentos que evidenciam o corpo e o sexo envolvidos em intensas práticas discursivas sobre o “eu” e a ordem social; constituindo-se, portanto, também em instâncias dinâmicas e mutáveis. O trabalho investiga ainda algumas construções contempo-râneas em torno do corpo, destacando questionamentos provocados pelo crescimento das práticas de “reprodução assistida”. Pretende, assim, colaborar com o desenvolvimento de estudos do gênero no campo do serviço social, estimulando análises que considerem os contextos sociais, históricos e culturais que articulam as experiências marcadas por gênero, bem como a formulação de políticas públicas nesta área.

  20. Intramuscular ganglia arising from the superior tibiofibular joint: CT and MR evaluation

    International Nuclear Information System (INIS)

    Bianchi, S.; Abdelwahab, I.F.; Kenan, S.; Zwass, A.; Ricci, G.; Palomba, G.

    1995-01-01

    To evaluate the role of magnetic resonance imaging (MRI) and computed tomography (CT) in the diagnosis of intramuscular ganglia (IMG) that arise from the superior tibiofibular joint (STFJ). Our series consisted of three men and three women. Four patients were studied by MRI, one by CT only, and two by both modalities. Contrast was used in one of the two patients studied by CT. MRI was obtained in at least two orthogonal planes to demonstrate the relation of the ganglia to STFJ. The MR and CT appearance of these ganglia was basically that of a well-defined soft tissue mass with low attenuation on CT images consistent with the presence of fluid. On MR studies, they had an isointense signal on T1-weighted images and a homogenous high-intensity signal on T2-weighted images. MRI demonstrated the attachment of these ganglia to the STFJ. CT and MRI were effective, noninvasive modalities in the evaluation of IMG. The imaging features on both modalities were consistent with the presence of fluid-containing lesions that had close proximity and were attached to the STFJ. The combination of location and the fluid consistency of these lesions facilitated the diagnosis. (orig.)

  1. The comprehensive liver transcriptome of two cattle breeds with different intramuscular fat content.

    Science.gov (United States)

    Wang, Xi; Zhang, Yuanqing; Zhang, Xizhong; Wang, Dongcai; Jin, Guang; Li, Bo; Xu, Fang; Cheng, Jing; Zhang, Feng; Wu, Sujun; Rui, Su; He, Jiang; Zhang, Ronghua; Liu, Wenzhong

    2017-08-26

    Intramuscular fat (IMF) content is an important determinant factor of meat quality in cattle. There is significant difference in IMF content between Jinnan and Simmental cattle. Here, to identify candidate genes and networks associated with IMF deposition, we deeply explored the transcriptome architecture of liver in these two cattle breeds. We sequenced the liver transcriptome of five Jinnan and three Simmental cattle, yielding about 413.9 million sequencing reads. 124 differentially expressed genes (DEGs) were detected, of which 53 were up-regulated and 71 were down-regulated in Jinnan cattle. 1282 potentially novel genes were also identified. Gene ontology analysis revealed these DEGs (including CYP21A2, PC, ACACB, APOA1, and FADS2) were significantly enriched in lipid biosynthetic process, regulation of cholesterol esterification, reverse cholesterol transport, and regulation of lipoprotein lipase activity. Genes involved in pyruvate metabolism pathway were also significantly overrepresented. Moreover, we identified an interaction network which related to lipid metabolism, which might be contributed to the IMF deposition in cattle. We concluded that the DEGs involved in the regulation of lipid metabolism could play an important role in IMF deposition. Overall, we proposed a new panel of candidate genes and interaction networks that can be associated with IMF deposition and used as biomarkers in cattle breeding. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. Isolated (localized) idiopathic granulomatous (giant cell) vasculitis in an intramuscular lipoma.

    Science.gov (United States)

    Fernando Val-Bernal, J; Val, Daniel; Calvo, Ignacio; Francisca Garijo, M

    2006-01-01

    Isolated (localized) idiopathic granulomatous vasculitis (IGV) is an uncommon, heterogeneous, and poorly defined group of disorders characterized by infiltration of the arterial wall caused by compactly grouped mononuclear phagocytes, with or without giant cells, in segmental distribution. We report on a 55-year-old woman with IGV limited to an intramuscular lipoma of the left thigh. The vasculitis was identified incidentally upon microscopic examination of the removed tumor. The IGV was centered on two medium-sized arteries, accompanied by narrowing of the lumens, and not associated with secondary changes such as infart or postinfart fibrosis. The inflammatory infiltrate was rich in T-lymphocytes and macrophages, with the presence of giant cells. The patient was asymptomatic and well in a follow-up period of 2 months, during which she was not treated. To our knowledge, this is the first report of lipoma involvement in localized IGV. It is important to distinguish cases of isolated intratumorous IGV from systemic disease, because the latter implies a poor prognosis and requires an aggressive treatment.

  3. Comparison of Intramuscular or Subcutaneous Injections vs. Castration in Pigs—Impacts on Behavior and Welfare

    Directory of Open Access Journals (Sweden)

    John McGlone

    2016-08-01

    Full Text Available Physical castration (PC is painful and stressful for nursing piglets. One alternative to PC is immunological castration (IC, but the pain and stress of handling associated with injections have not been assessed. The objectives of this study were to measure the pain and distress of subcutaneous (SQ and intramuscular (IM injections compared to PC in piglets, and to compare SQ or IM injections in finishing pigs. After farrowing, 3 to 5 d old male piglets were randomly assigned to (control no handling treatment (NO, sham-handling (SHAM, IM, SQ, or PC. Finishing pigs were assigned to NO, SHAM, IM, or SQ. Behavior was monitored for 1 h prior and 1 h post treatment in each age group. Social, feeding behaviors, and signs of pain were recorded. Finishing pigs treated with SQ injections had higher feeding behaviors pre-treatment than they did post-treatment. Overall, physical castrations caused measurable pain-like behaviors and general behavioral dysregulation at a much higher level than the other treatment groups. SQ and IM injections did not cause either significant behavioral or physiological alterations in piglets. SQ injections caused a decrease in finishing pig feed behaviors post treatment ( p = 0.02 and SHAM treated finishing pigs spent significantly more time lying than the other treatment groups. In general IM and SQ injections did not cause any other significant changes in behavior or physiology.

  4. A Key Gene, PLIN1, Can Affect Porcine Intramuscular Fat Content Based on Transcriptome Analysis

    Directory of Open Access Journals (Sweden)

    Bojiang Li

    2018-04-01

    Full Text Available Intramuscular fat (IMF content is an important indicator for meat quality evaluation. However, the key genes and molecular regulatory mechanisms affecting IMF deposition remain unclear. In the present study, we identified 75 differentially expressed genes (DEGs between the higher (H and lower (L IMF content of pigs using transcriptome analysis, of which 27 were upregulated and 48 were downregulated. Notably, Kyoto Encyclopedia of Genes and Genomes (KEGG enrichment analysis indicated that the DEG perilipin-1 (PLIN1 was significantly enriched in the fat metabolism-related peroxisome proliferator-activated receptor (PPAR signaling pathway. Furthermore, we determined the expression patterns and functional role of porcine PLIN1. Our results indicate that PLIN1 was highly expressed in porcine adipose tissue, and its expression level was significantly higher in the H IMF content group when compared with the L IMF content group, and expression was increased during adipocyte differentiation. Additionally, our results confirm that PLIN1 knockdown decreases the triglyceride (TG level and lipid droplet (LD size in porcine adipocytes. Overall, our data identify novel candidate genes affecting IMF content and provide new insight into PLIN1 in porcine IMF deposition and adipocyte differentiation.

  5. Pharmacokinetics of enrofloxacin after oral, intramuscular and bath administration in crucian carp (Carassius auratus gibelio).

    Science.gov (United States)

    Shan, Q; Fan, J; Wang, J; Zhu, X; Yin, Y; Zheng, G

    2018-02-01

    The pharmacokinetics of enrofloxacin (ENR) was studied in crucian carp (Carassius auratus gibelio) after single administration by intramuscular (IM) injection and oral gavage (PO) at a dose of 10 mg/kg body weight and by 5 mg/L bath for 5 hr at 25°C. The plasma concentrations of ENR and ciprofloxacin (CIP) were determined by HPLC. Pharmacokinetic parameters were calculated based on mean ENR or CIP concentrations using WinNonlin 6.1 software. After IM, PO and bath administration, the maximum plasma concentration (C max ) of 2.29, 3.24 and 0.36 μg/ml was obtained at 4.08, 0.68 and 0 hr, respectively; the elimination half-life (T 1/2β ) was 80.95, 62.17 and 61.15 hr, respectively; the area under the concentration-time curve (AUC) values were 223.46, 162.72 and 14.91 μg hr/ml, respectively. CIP, an active metabolite of enrofloxacin, was detected and measured after all methods of drug administration except bath. It is possible and practical to obtain therapeutic blood concentrations of enrofloxacin in the crucian carp using IM, PO and bath immersion administration. © 2017 John Wiley & Sons Ltd.

  6. Muscle and genotype effects on fatty acid composition of goat kid intramuscular fat

    Directory of Open Access Journals (Sweden)

    Valeriano Domenech

    2011-07-01

    Full Text Available Little is known about the fatty acid composition of the major muscles in goats from different breeds. Forty entire male suckling kids, 20 Criollo Cordobes and 20 Anglo Nubian, were slaughtered at 75 days of age and the fatty acid composition of their longissimus thoracis (LT and semitendinosus (ST muscles was analysed to clarify the effects of genotype and muscle type on goat kid meat. Genotype had a great influence on the fatty acid composition of goat kid meat. Meat from Criollo Cordobes had greater saturated (P<0.001 and lower monounsaturated (P<0.001 and polyunsaturated fatty acids (P=0.002 concentration than meat from Anglo Nubian, showing higher saturated fatty acids (SFA. On the other hand, intramuscular fat content from both genotypes was higher (P=0.042 in ST muscle, while the lowest cholesterol levels were observed in ST of Criollo Cordobes (P=0.038. That higher fat content resulted in lower relative contents of total polyunsaturated (P<0.001 and n-3 (P=0.002 fatty acids due to the lower contribution of the membrane phospholipids.

  7. Intramuscular keratocyst as a soft tissue counterpart of keratocystic odontogenic tumor: differential diagnosis by immunohistochemistry.

    Science.gov (United States)

    Abé, Tatsuya; Maruyama, Satoshi; Yamazaki, Manabu; Essa, Ahmed; Babkair, Hamzah; Mikami, Toshihiko; Shingaki, Susumu; Kobayashi, Tadaharu; Hayashi, Takafumi; Cheng, Jun; Saku, Takashi

    2014-01-01

    Keratocystic odontogenic tumor (KCOT), a developmental jaw cyst previously referred to as odontogenic keratocyst (OKC), typically arises in the jawbone. In this article, however, we report a case of KCOT located within the temporalis muscle. We compared its immunohistochemical profiles with those of authentic jaw KCOT, orthokeratinized odontogenic cyst, and epidermoid cyst in order to consider whether a soft tissue counterpart of KCOT could be a separate disease entity. The patient was a 46-year-old man with a well-defined cystic lesion within the left temporalis muscle. On computed tomographic images, the lesion was recognized as a cystic lesion, although KCOT was not included in the clinical differential diagnoses. The location of the lesion was not within bone but, rather, within the temporalis muscle that was attached to the jawbones. Our review of the literature has disclosed more than 20 peripheral KCOT cases of the oral mucosa and more than 10 cases of the skin, but only 1 case arising in muscle. Immunohistochemical investigation of the present intramuscular case reveals KCOT-characteristic profiles distinct from the other 3 types of cysts investigated. The results indicate that KCOT-like lesions can arise within soft tissues, although use of the term odontogenic might seem inappropriate in those cases. © 2013.

  8. Investigation of pharmacokinetic parameters of tiamulin after intramuscular and subcutaneous administration in normal dogs.

    Science.gov (United States)

    Laber, G

    1988-03-01

    Kinetic variables for tiamulin in the normal dog have been determined. Serum concentrations of tiamulin were compared after intramuscular (i.m.) and subcutaneous (s.c.) administration of a single dose of tiamulin. Following a single i.m. dose of 10 mg/kg body weight, the compound was calculated to have a Cmax = 0.61 +/- 0.15 micrograms/ml, a Tmax = 6 h and a t1/2 = 4.7 +/- 1.4 h. Tiamulin showed dose-dependent pharmacokinetics when given as a single s.c. dose of either 10 mg or 25 mg/kg body weight. For the lower dose, the values Cmax = 1.55 +/- 0.11 micrograms/ml, Tmax = 8 h and t1/2 = 4.28 +/- 0.18 h were obtained. For the higher dose Cmax = 3.14 +/- 0.04 micrograms/ml, Tmax = 8 h and t1/2 = 12.4 +/- 3.4 h were calculated. When tiamulin was administered subcutaneously at a dose rate of 10 mg/kg body weight, higher and better maintained serum levels were achieved than those following i.m. administration. After repeated s.c. doses no significant accumulation of tiamulin occurred. Assuming that a continuous effective serum concentration is necessary throughout the course of therapy, these data would indicate that tiamulin should be given every 24 h.

  9. Pharmacokinetics of imipenem after intravenous, intramuscular and subcutaneous administration to cats.

    Science.gov (United States)

    Albarellos, Gabriela A; Denamiel, Graciela A; Montoya, Laura; Quaine, Pamela C; Lupi, Martín P; Landoni, María F

    2013-06-01

    The study describes the pharmacokinetics and predicted efficacy of imipenem after intravenous (IV), intramuscular (IM) and subcutaneous (SC) administration to five adult cats at a dose of 5 mg/kg. Susceptibility to imipenem [minimum inhibitory concentration (MIC)] was determined for antimicrobial resistant Escherichia coli (n = 13) and staphylococci (n = 3) isolated from domestic cat infections (urinary system, skin and conjunctiva). Maximum plasma concentrations of imipenem were 13.45 µg/ml (IV), 6.47 µg/ml (IM) and 3.83 µg/ml (SC). Bioavailability was 93.18% (IM) and 107.90% (SC). Elimination half-lives for IV, IM and SC administration were 1.17, 1.44 and 1.55 h, respectively. All tested bacteria were susceptible to imipenem; MIC values were 0.03 µg/ml for Staphylococcus species and imipenem concentrations remained above a MIC of 0.5 µg/ml for approximately 4 h (IV and IM) and 9 h (SC). Imipenem would be predicted to be effective for the treatment of antimicrobial resistant bacterial infections in cats at a dosage of 5 mg/kg every 6-8 h (IV, IM), or longer for the SC route. However, clinical trials are mandatory to establish its efficacy and proper dosing.

  10. Investigation of DNA Integration into Reproductive Organs Following Intramuscular Injection of DNA in Mice

    Directory of Open Access Journals (Sweden)

    Fatemeh Vahedi

    2012-10-01

    Full Text Available Background: DNA immunization with plasmid DNA encoding bacterial, viral, parasitic, and tumor antigens has been reported to trigger protective immunity. The use of plasmid DNA vaccinations against many diseases has produced promising results in animal and human clinical trials; however, safety concerns about the use of DNA vaccines exist, such as the possibility of integration into the host genome, and elicitation of adverse immune responses. Methods: In this study, we examined the potential integration and bio-distribution of pcDNA3.1+PA, a new vaccine candidate with GenBank accession # EF550208, encoding the PA63 gene, in reproductive organs of mice; ovaries and uterus in female, and testis in male. Animals of both sexes were injected intramuscularly with pcDNA3.1+PA. Host genome integration and tissue distribution were examined using PCR and RT-PCR two times monthly for six months. Results: RT-PCR confirmed that pcDNA3.1+PA was not integrated into the host genome and did not enter reproductive organs. Conclusions: This finding has important implications for the use of pcDNA3.1+PA plasmid as a vaccine and opens new perspectives in the DNA vaccine area.

  11. Active Mycobacterium Infection Due to Intramuscular BCG Administration Following Multi-Steps Medication Errors

    Directory of Open Access Journals (Sweden)

    MohammadReza Rafati

    2015-10-01

    Full Text Available Bacillus Calmette-Guérin (BCG is indicated for treatment of primary or relapsing flat urothelial cell carcinoma in situ (CIS of the urinary bladder. Disseminated infectious complications occasionally occur due to BCG as a vaccine and intravesical therapy.  Intramuscular (IM or Intravenous (IV administrations of BCG are rare medication errors which are more probable to produce systemic infections. This report presents 13 years old case that several steps medication errors occurred consequently from physician handwriting, pharmacy dispensing, nursing administration and patient family. The physician wrote βHCG instead of HCG in the prescription. βHCG was read as BCG by the pharmacy staff and 6 vials of intravesical BCG were administered IM twice a week for 3 consecutive weeks. The patient experienced fever and chills after each injection, but he was admitted 2 months after first IM administration of BCG with fever and pancytopenia. Unfortunately four month after using drug, during second admission duo to cellulitis at the sites of BCG injection the physicians diagnosed the medication error. Using handwritten prescription and inappropriate abbreviations, spending inadequate time for taking a brief medical history in pharmacy, lack of verifying name, dose and wrote before medication administration and lack of considering medication error as an important differential diagnosis had roles to occur this multi-steps medication error.

  12. Nitric oxide nanoparticles: pre-clinical utility as a therapeutic for intramuscular abscesses.

    Science.gov (United States)

    Schairer, David; Martinez, Luis R; Blecher, Karin; Chouake, Jason; Nacharaju, Parimala; Gialanella, Philip; Friedman, Joel M; Nosanchuk, Joshua D; Friedman, Adam

    2012-01-01

    Nitric oxide (NO) is a critical component of host defense against invading pathogens; however, its therapeutic utility is limited due to a lack of practical delivery systems. Recently, a NO-releasing nanoparticulate platform (NO-np) was shown to have in vitro broad-spectrum antimicrobial activity and in vivo pre-clinical efficacy in a dermal abscess model. To extend these findings, both topical (TP) and intralesional (IL) NO-np administration was evaluated in a MRSA intramuscular murine abscess model and compared with vancomycin. All treatment arms accelerated abscess clearance clinically, histologically, and by microbiological assays on both days 4 and 7 following infection. However, abscesses treated with NO-np via either route demonstrated a more substantial, statistically significant decrease in bacterial survival based on colony forming unit assays and histologically revealed less inflammatory cell infiltration and preserved muscular architecture. These data suggest that the NO-np may be an effective addition to our armament for deep soft tissue infections.

  13. A Key Gene, PLIN1, Can Affect Porcine Intramuscular Fat Content Based on Transcriptome Analysis.

    Science.gov (United States)

    Li, Bojiang; Weng, Qiannan; Dong, Chao; Zhang, Zengkai; Li, Rongyang; Liu, Jingge; Jiang, Aiwen; Li, Qifa; Jia, Chao; Wu, Wangjun; Liu, Honglin

    2018-04-04

    Intramuscular fat (IMF) content is an important indicator for meat quality evaluation. However, the key genes and molecular regulatory mechanisms affecting IMF deposition remain unclear. In the present study, we identified 75 differentially expressed genes (DEGs) between the higher (H) and lower (L) IMF content of pigs using transcriptome analysis, of which 27 were upregulated and 48 were downregulated. Notably, Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis indicated that the DEG perilipin-1 ( PLIN1 ) was significantly enriched in the fat metabolism-related peroxisome proliferator-activated receptor (PPAR) signaling pathway. Furthermore, we determined the expression patterns and functional role of porcine PLIN1. Our results indicate that PLIN1 was highly expressed in porcine adipose tissue, and its expression level was significantly higher in the H IMF content group when compared with the L IMF content group, and expression was increased during adipocyte differentiation. Additionally, our results confirm that PLIN1 knockdown decreases the triglyceride (TG) level and lipid droplet (LD) size in porcine adipocytes. Overall, our data identify novel candidate genes affecting IMF content and provide new insight into PLIN1 in porcine IMF deposition and adipocyte differentiation.

  14. Intramuscular anti-D in chronic immune thrombocytopenia children with severe thrombocytopenia.

    Science.gov (United States)

    Sirachainan, Nongnuch; Anurathapan, Usanarat; Chuansumrit, Ampaiwan; Songdej, Duantida; Wongwerawattanakoon, Pakawan; Hutspardol, Sakara; Kitpoka, Pimpun

    2013-12-01

    Nine patients with chronic immune thrombocytopenia and platelet counts anti-D. Phase 1 was anti-D daily for 5 days, followed by phase 2, anti-D weekly for 12 weeks and withheld when platelet counts ≥ 20 × 10(9) /L, and then phase 3 was anti-D once every 2 weeks for 24 weeks. According to the International Working Group criteria, in phase 1, 66.7% of patients responded to the treatment. In phases 2 and 3, 11.1% (0-41.7%) and 7.7% (0-33.3%) of total episodes of follow up, respectively, responded to the treatment. Therefore, intramuscular anti-D given at a dose of 10 mcg/kg for 5 days is an alternative method to raise platelet counts in chronic immune thrombocytopenia children with severe thrombocytopenia where the intravenous form of anti-D is not available. © 2013 The Authors. Pediatrics International © 2013 Japan Pediatric Society.

  15. Pharmacokinetic properties of methadone hydrochloride after single intramuscular administration in adult dairy goats.

    Science.gov (United States)

    Kock, M; Thompson, E; Vulliet, P R; Brooks, D L

    1994-10-01

    Pharmacokinetic parameters of methadone were studied in adult dairy goats. Five goats were each given methadone hydrochloride as a single 0.2 mg/kg of body weight dosage by intramuscular (IM) administration. Plasma methadone concentrations were determined for 96 h after dosing. Plasma methadone concentrations after IM administration were best described by an open one-compartment model. Overall elimination half-life (t1/2) was 1.38 h. Peak plasma concentrations were reached 0.25 h after dosing, and the actual plasma concentration averaged 37.8 ng/ml (SD = 12.76) at that time. The data obtained from this study suggest that plasma concentrations, similar to those that are analgesic in humans, can be achieved after IM administration of methadone at a dose rate of 0.2 mg/kg of body weight. In addition, these plasma concentrations can be maintained for up to 3 h after a single injection and, therefore, may provide satisfactory analgesia for such period.

  16. Lower aerobic capacity was associated with abnormal intramuscular energetics in patients with metabolic syndrome

    International Nuclear Information System (INIS)

    Yokota, Takashi; Kinugawa, Shintaro; Okita, Koichi

    2011-01-01

    Lower aerobic capacity is a strong and independent predictor of cardiovascular morbidity and mortality in patients with metabolic syndrome (MetS). However, the mechanisms are not fully elucidated. We tested the hypothesis that skeletal muscle dysfunction could contribute to the lower aerobic capacity in MetS patients. The incremental exercise tests with cycle ergometer were performed in 12 male patients with MetS with no habitual exercise and 11 age-, sex- and activity-matched control subjects to assess the aerobic capacity. We performed 31 phosphorus-magnetic resonance spectroscopy (MRS) to assess the high-energy phosphate metabolism in skeletal muscle during aerobic exercise. Proton-MRS was also performed to measure intramyocellular lipid (IMCL) content. Peak oxygen uptake (peak VO 2 ; 34.1±6.2 vs. 41.4±8.4 ml kg -1 min -1 , P -1 min -1 , P 2 (r=-0.64) and AT (r=-0.60), respectively. IMCL content was threefold higher in MetS and was inversely correlated with peak VO 2 (r=-0.47) and AT (r=-0.52), respectively. Moreover, there was a positive correlation between IMCL content and PCr loss (r=0.64). These results suggested that lean-body aerobic capacity in MetS patients was lower compared with activity-matched healthy subjects, which might be due to the reduced intramuscular fatty acid oxidative metabolism. (author)

  17. Pharmacokinetics of meropenem after intravenous, intramuscular and subcutaneous administration to cats.

    Science.gov (United States)

    Albarellos, Gabriela A; Montoya, Laura; Passini, Sabrina M; Lupi, Martín P; Lorenzini, Paula M; Landoni, María F

    2016-12-01

    The aim of the study was to describe the pharmacokinetics and predicted efficacy of meropenem after intravenous (IV), intramuscular (IM) and subcutaneous (SC) administration to cats at a single dose of 10 mg/kg. Five adult healthy cats were used. Blood samples were withdrawn at predetermined times over a 12 h period. Meropenem concentrations were determined by microbiological assay. Pharmacokinetic analyses were performed with computer software. Initial estimates were determined using the residual method and refitted by non-linear regression. The time that plasma concentrations were greater than the minimum inhibitory concentration (T >MIC) was estimated by applying bibliographic MIC values and meropenem MIC breakpoint. Maximum plasma concentrations of meropenem were 101.02 µg/ml (C p(0) , IV), 27.21 µg/ml (C max , IM) and 15.57 µg/ml (C max , SC). Bioavailability was 99.69% (IM) and 96.52 % (SC). Elimination half-lives for the IV, IM and SC administration were 1.35, 2.10 and 2.26 h, respectively. Meropenem, when administered to cats at a dose of 10 mg/kg q12h,, is effective against bacteria with MIC values of 6 μg/ml, 7 μg/ml and 10 μg/ml for IV, IM and SC administration, respectively. However, clinical trials are necessary to confirm clinical efficacy of the proposed dosage regimen. © The Author(s) 2015.

  18. Intramuscular pressures in antigravity muscles using gravity-independent, pneumatic hardware.

    Science.gov (United States)

    Macias, Brandon R; Minocha, Ranjeet; Cutuk, Adnan A; Hill, James; Shiau, Jonathon; Hargens, Alan R

    2008-08-01

    Resistive exercise helps prevent muscle atrophy in microgravity, but better exercise equipment is needed. Therefore, the purpose of this study was to determine if a pneumatic, gravity-independent leg-press device (LPD) provides sufficient force to leg musculature. We hypothesized that intramuscular pressure (IMP), a quantitative index of muscle force, is greater in the antigravity superficial posterior and deep posterior compartments than in the non-antigravity anterior compartment during bilateral leg-press exercise. Millar pressure transducers were inserted into the anterior, lateral, superficial posterior, and deep posterior muscle compartments of the left leg of eight healthy subjects (three women, five men). Subjects were supine on the Keiser SX-1, a pneumatic LPD. Then maximal voluntary contraction (MVC) was determined; each subject performed three consecutive voluntary contractions at approximately 18%, 50%, and 100% MVC while continuously measuring IMP. Repeated measures ANOVA were used to determine differences of IMPs between compartments and loads. The magnitudes of IMP (mean +/- SEM) at 18 - 3% (abbreviated approximately 18%), 50%, and 100% MVC in the superficial and deep posterior compartments were significantly greater than that in the anterior compartment during exercise (P antigravity compartments as compared to the non-antigravity compartment. Since antigravity muscles of the leg are contained primarily in the superficial and deep posterior compartments, the LPD may help prevent muscle atrophy associated with microgravity.

  19. Transcriptome changes favoring intramuscular fat deposition in the longissimus muscle following castration of bulls.

    Science.gov (United States)

    Jeong, J; Bong, J; Kim, G D; Joo, S T; Lee, H-J; Baik, M

    2013-10-01

    Castration increases intramuscular fat (IMF) deposition, improving beef quality in cattle. The present study was performed to determine the global transcriptome changes following castration of bulls and to identify genes associated with IMF deposition in the longissimus dorsi (LM) of Korean cattle. A customized bovine CombiMatrix oligonucleotide microarray was constructed, and transcriptome changes following castration were determined by microarray hybridization. Transcriptome comparison between bulls and steers indicated that 428 of 8,407 genes were differentially expressed in the LM by greater than two fold (P castration. Castration upregulated transcription of adipogenic perilipin 2 (PLIN2) and visfatin, lipogenic fatty acid synthase, fatty acid esterification 1-acylglycerol-3-phosphate O-acyltransferase 5, and many fatty acid oxidation-related genes. Many TCA cycle and OP genes were also transcriptionally upregulated. Correlation analysis indicated that the IMF content in the LM was highly correlated with mRNA levels of PLIN2 (r = 0.70, P castration shifts transcription of lipid metabolism genes, favoring IMF deposition by increasing adipogenesis, lipogenesis, and triglyceride synthesis. This study also indicated that castration increases transcription of genes involved in fatty acid oxidation and subsequent energy production (TCA and OP genes). Our microarray analysis provided novel information that castration alters the transcriptome associated with lipid/energy metabolism, favoring IMF deposition in the LM.

  20. First reported experience with intramuscular diaphragm pacing in replacing positive pressure mechanical ventilators in children.

    Science.gov (United States)

    Onders, Raymond P; Ponsky, Todd A; Elmo, MaryJo; Lidsky, Karen; Barksdale, Edward

    2011-01-01

    Diaphragm pacing (DP) has been shown to successfully replace mechanical ventilators for adult tetraplegic patients with chronic respiratory insufficiency. This is the first report of DP in ventilator-dependent children. This was a prospective interventional experience under institutional review board approval. Diaphragm pacing involves outpatient laparoscopic diaphragm motor point mapping to identify the site where stimulation causes maximum diaphragm contraction with implantation of 4 percutaneous intramuscular electrodes. Diaphragm conditioning ensues to wean the child from the ventilator. Six children were successfully implanted ranging from 5 to 17 years old with the smallest 15 kg in weight. Length of time on mechanical ventilation ranged from 11 days to 7.6 years with an average of 3.2 years. In all patients, DP provided tidal volumes above basal needs. Five of the patients underwent a home-based weaning program, whereas one patient who was implanted only 11 days post spinal cord injury never returned to the ventilator with DP use. Another patient was weaned from the ventilator full time but died of complications of his underlying brain stem tumor. The remaining patients weaned from the ventilator for over 14 hours a day and/or are actively conditioning their diaphragms. Diaphragm pacing successfully replaced mechanical ventilators, which improves quality of life. Copyright © 2011 Elsevier Inc. All rights reserved.

  1. Single-use autoinjector for once-weekly intramuscular injection of IFNβ-1a.

    Science.gov (United States)

    Limmroth, Volker; Gerbershagen, Kathrin

    2014-12-01

    IFNβ products and glatiramer acetate are established treatment first-line options in long-term disease-modifying therapy of multiple sclerosis (MS). These self-injectable medications are used once weekly to once daily. Injection-related issues are common patient-cited reasons for nonadherence. Autoinjectors have been shown to support long-term adherence to injectable medications. The ability to self-inject in MS patients has been associated with a reduced risk of missed injections and drug discontinuation, and a beneficial effect on patient independence. The recently introduced easy-to-use prefilled once-weekly pen is a safe and effective device for intramuscular (IM) IFNβ-1a application and provides a convenient method for self-injection. We reviewed the available published evidence on the characteristics of this device. The once-weekly pen facilitates self-injection and was preferred over prefilled syringes by patients in a prospective open-label, multicenter Phase IIIb trial in MS patients who had been using IM IFNβ-1a in prefilled syringes. The simple and safe handling, shielded short needle, single-use disposable design and virtually painless injection by the device may contribute to adherence, quality of life and independence in patients using IM IFNβ-1a.

  2. The effect of air-lock technique on pain at the site of intramuscular injection

    Directory of Open Access Journals (Sweden)

    Dilek K. Yilmaz

    2016-03-01

    Full Text Available Objectives: To investigate the effects of air-lock technique (ALT on pain of intramuscular (IM injection delivered to the ventrogluteal and dorsogluteal site (DS. Methods: A randomized controlled trial design was used to assess the pain intensity associated with IM injections administered using 2 different methods and injection sites. Recruitment of patients was carried out between April and August 2013 at the Department of Brain Surgery, Cekirge State Hospital, Bursa, Turkey. The sample comprised 60 patients who developed no complications at the IM site, and had no illness that could affect their perception of pain. The patients were randomly divided into 2 groups of 30 patients. Patients in the first group received injections in the ventrogluteal site (VS, while the DS was used for injections in the second group. Patients in each group received 2 injections, one using ALT and one not using the technique. After each injection, the pain felt by patients during the injection was immediately assessed using a visual analog scale. Results: The mean pain score after injections to the DS by the ALT was 3.30 ± 2.70, while the mean pain score after injections to the VS using the same technique was 2.53 ± 2.52. Conclusion: Although the difference between groups was not significant, the results of the study supported the idea that injections delivered to the VS by ALT are less painful than those delivered to the DS.

  3. An interlaboratory study of the pharmacokinetics of testosterone following intramuscular administration to Thoroughbred horses.

    Science.gov (United States)

    Moeller, B C; Sams, R A; Guinjab-Cagmat, J; Szabo, N J; Colahan, P; Stanley, S D

    2011-12-01

    Testosterone is an anabolic androgenic steroid (AAS) that is endogenously produced by both male and female horses that also has the potential for abuse when administered exogenously to race horses. To recommend appropriate withdrawal guidelines so that veterinarians can discontinue therapeutic use prior to competition, the pharmacokinetics and elimination of testosterone were investigated. An aqueous testosterone suspension was administered intramuscularly in the neck of Thoroughbred horses (n = 20). The disposition of testosterone from this formulation was characterized by an initial, rapid absorption phase followed by a much more variable secondary absorption phase. The median terminal half-life was 39 h. A second focus of this study was to compare the testosterone concentrations determined by two different laboratories using a percentage similarity model with a coefficient of variation of 16.5% showing good agreement between the two laboratories results. Based on the results of this study, a withdrawal period of 30 days for aqueous testosterone administered IM is recommended. © 2011 Blackwell Publishing Ltd.

  4. Streptococcus bovis/S. equinus complex septicemia in a group of calves following intramuscular vaccination.

    Science.gov (United States)

    Clarke, Lorelei L; Fathke, Robert L; Sanchez, Susan; Stanton, James B

    2016-07-01

    Organisms previously classified as Streptococcus bovis (i.e., the S. bovis/S. equinus complex) are common in cattle feces, but may also act as opportunistic pathogens. In the current work, Streptococcus infantarius subsp. coli, a member of this complex, was associated of a cluster of calves that died within hours of injection with a modified live viral vaccine. Within 12 h of vaccination of 46 calves at a cow/calf operation, 4 calves had died, 3 calves were ill, and 1 unvaccinated cow was dead. Autopsies were performed on the cow, 2 dead calves, and 1 affected surviving calf, which was euthanized ~24 h after vaccine administration. The animals had similar gross anatomic and microscopic lesions, including subcutaneous and intramuscular dark hemorrhage on the caudal neck, multiorgan ecchymosis and petechiation, and alveolitis to interstitial pneumonia. Gram-positive cocci were in the vasculature of the lung and skeletal muscle, and S. infantarius subsp. coli was cultured from tissues and from the vaccines used on affected animals, but not in vials used on unaffected animals. Together, these findings suggest death caused by streptococcal septicemia and toxemia as a result of contamination. © 2016 The Author(s).

  5. Pharmacokinetic Evaluation of a Single Intramuscular High Dose versus an Oral Long-Term Supplementation of Cholecalciferol.

    Directory of Open Access Journals (Sweden)

    Katharina Wylon

    Full Text Available Vitamin D deficiency is frequent during the winter and occurs throughout the year in the elderly or patients suffering from autoimmune diseases. The objective of this study was to evaluate the pharmacokinetic properties of oral supplementation versus a single intramuscular injection of cholecalciferol in healthy individuals.Up to 8,000 I.U. oral cholecalciferol was administered daily for 84 days in a 4 week dose-escalation setting to vitamin D deficient individuals. In another cohort, a single intramuscular injection of 100,000 I.U. cholecalciferol was given. In both cohorts, individuals without vitamin D intake served as the comparison group. 25-hydroxyvitamin D (25(OHD concentrations were measured in all individuals at defined time points throughout the studies.The mean 25(OHD serum concentration increased significantly after oral cholecalciferol intake compared to the control group (day 28: 83.4 nmol/l and 42.5 nmol/l; day 56: 127.4 nmol/l and 37.3 nmol/l; day 84: 159.7 nmol/l and 30.0 nmol/l. In individuals receiving 100,000 I.U. cholecalciferol intramuscular, the mean 25(OHD serum concentration peaked after 4 weeks measuring 70.9 nmol/l compared to 32.7 nmol/l in the placebo group (p = 0.002. The increase of 25(OHD serum concentrations after 28 days was comparable between both routes of administration (p = 0.264.Oral and intramuscular cholecalciferol supplementation effectively increased serum 25(OHD concentrations.

  6. Electrical muscle stimulation elevates intramuscular BDNF and GDNF mRNA following peripheral nerve injury and repair in rats.

    Science.gov (United States)

    Willand, Michael P; Rosa, Elyse; Michalski, Bernadeta; Zhang, Jennifer J; Gordon, Tessa; Fahnestock, Margaret; Borschel, Gregory H

    2016-10-15

    Despite advances in surgery, patients with nerve injuries frequently have functional deficits. We previously demonstrated in a rat model that daily electrical muscle stimulation (EMS) following peripheral nerve injury and repair enhances reinnervation, detectable as early as two weeks post-injury. In this study, we explain the enhanced early reinnervation observed with electrical stimulation. In two groups of rats, the tibial nerve was transected and immediately repaired. Gastrocnemius muscles were implanted with intramuscular electrodes for sham or muscle stimulation. Muscles were stimulated daily, eliciting 600 contractions for one hour/day, repeated five days per week. Sixteen days following nerve injury, muscles were assessed for functional reinnervation by motor unit number estimation methods using electromyographic recording. In a separate cohort of rats, surgical and electrical stimulation procedures were identical but muscles and distal nerve stumps were harvested for molecular analysis. We observed that stimulated muscles had significantly higher motor unit number counts. Intramuscular levels of brain-derived and glial cell line-derived neurotrophic factor (BDNF and GDNF) mRNA were significantly upregulated in muscles that underwent daily electrical stimulation compared to those without stimulation. The corresponding levels of trophic factor mRNA within the distal stump were not different from one another, indicating that the intramuscular electrical stimulus does not modulate Schwann cell-derived trophic factor transcription. Stimulation over a three-month period maintained elevated muscle-derived GDNF but not BDNF mRNA. In conclusion, EMS elevates intramuscular trophic factor mRNA levels which may explain how EMS enhances neural regeneration following nerve injury. Copyright © 2016 IBRO. Published by Elsevier Ltd. All rights reserved.

  7. Antipyretic efficacy and tolerability of oral ibuprofen, oral dipyrone and intramuscular dipyrone in children: a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Judith Prado

    Full Text Available CONTEXT AND OBJECTIVE: Dipyrone is a widely used over-the-counter antipyretic in Latin America, and elsewhere among Latin immigrants. Despite limited evidence, physicians often prescribe oral ibuprofen or intramuscular dipyrone as the most effective antipyretics. Our aim was to compare the antipyretic efficacy and tolerability of a single dose of oral ibuprofen, oral dipyrone or intramuscular dipyrone in febrile children. DESIGN AND SETTING: Randomized, single-blind clinical trial, at San Bartolomé Mother-Child National Teaching Hospital, Lima, Peru. METHODS: Children from six months to six years old with fever (rectal temperature: 38.3 to 39.8° C in the emergency ward between February and June 2003 were eligible. Seventy-five children were randomly assigned to receive a single dose of oral ibuprofen (10 mg/kg, oral dipyrone (15 mg/kg or intramuscular dipyrone (15 mg/kg. The primary outcome was mean temperature reduction after 30, 45, 60, 90 and 120 minutes. Secondary outcomes were fever-associated symptoms and clinical adverse events. RESULTS: Fever decreased by about 0.5° C after 45 minutes and by about 1.0° C after 120 minutes in all three groups. Mean temperatures were similar for the three groups at all times. There was a significant decrease in fever-associated symptoms for all groups. Six patients (four receiving oral dipyrone and two receiving ibuprofen were withdrawn because of vomiting within 20 minutes after first dose of study medication. One patient assigned to oral ibuprofen presented transient urticaria. CONCLUSIONS: Antipyretic efficacy and tolerability were similar for oral ibuprofen, oral dipyrone and intramuscular dipyrone. Oral antipyretics seem more appropriate for feverish children.

  8. Gluteal Augmentation With Intramuscular Implants in Patients With Human Immunodeficiency Virus With Lipoatrophy Related to the Use of Antiretroviral Therapy.

    Science.gov (United States)

    Andrade, Guilherme Augusto; Coltro, Pedro Soler; Barros, Mário Eduardo; Müller Neto, Bruno Francisco; Lima, Renan Victor; Farina, Jayme Adriano

    2017-11-01

    Lipodystrophy syndrome associated with highly active antiretroviral therapy (HAART) may lead to low self-esteem and poor compliance with the drug treatment on patients infected with human immunodeficiency virus (HIV), which is a matter of concern for the health system. The aim of this study was to evaluate patients with HIV submitted to gluteal augmentation with intramuscular silicone implants to correct gluteal lipoatrophy related to the use of HAART. This is a retrospective evaluation of 10 patients submitted to gluteal augmentation with intramuscular silicone implant for correction of gluteal lipoatrophy related to the use of HAART, operated between 2012 and 2015. Postoperative complications and the degree of patient's satisfaction were analyzed. There were 3 postoperative complications including 1 case of surgical wound dehiscence and 2 cases of seroma. Six months after surgery, 8 patients had an excellent degree of satisfaction, and 2 patients had a good degree of satisfaction related to the procedure. Although this intervention does not offer functional advantages, it improves the body contour, increases patients' self-esteem, and helps them to accept their body image. These advantages can lead to higher compliance with prolonged HAART. Gluteal augmentation with intramuscular silicone implant can be a viable option to treat patients with HIV with gluteal lipoatrophy related to the use of HAART. The patients were satisfied with the outcomes of the procedure, and there were only minor self-limited postoperative complications.

  9. Hiperekplexia: Um Caso Raro de Hipertonia Neonatal

    OpenAIRE

    Alegria, Artur; Santos, Manuela; Coelho, Elisabete; Cardoso, Maria Luís

    2014-01-01

    A hiperekplexia ou «doença do sobressalto» é um síndroma clínico muito raro caracterizado por uma resposta de sobressalto exagerada a estímulos sensoriais inesperados e hipertonia generalizada neonatal transitória, resultante de um defeito genético dos receptores da glicina. Descrevemos um novo caso clínico desta doença, num recém-nascido cuja história familiar era negativa. Após o nascimento apresentou-se com hipertonia e rigidez muscular generalizadas, agravadas em resposta a estímulos táct...

  10. Um lugar para a Filosofia?

    Directory of Open Access Journals (Sweden)

    Samir Dessbesel Ferreira

    2010-01-01

    Full Text Available De que modo pode a Filosofia integrar-se às demais disciplinas da grade curricular dos cursos técnicos do IFSul? E como se insere uma disciplina como essa em instituições de ensino que têm tradicionalmente como foco o ensino tecnológico e profissionalizante, como são os Institutos Federais? Primeiramente, a Filosofia poderia contribuir na formação do profissional egresso, desenvolvendo-lhe competências relacionadas ao filosofar, em especial as relacionadas ao raciocínio abstrato e à comunicação, o que poderia vir a fazer a diferença no mercado de trabalho. Assim, os Institutos Federais ofereceriam um ensino de excelência com o objetivo de formar o técnico mais bem qualificado possível ao mercado de trabalho. Todavia, o aparelhamento técnico de nossos jovens, embora essencial para o desenvolvimento do País, não pode apresentar-se como a preocupação prioritária dos educadores, pois é fundamental considerar-se a formação integral da pessoa humana. Qual educação, afinal, queremos? E qual o papel da escola pública em nossa sociedade? O direcionamento unilateral à qualificação profissional pode levar-nos à formação de uma espécie de “superpeão”. A escola não pode ser serva do mercado. Ela tem o papel maior de agente de questionamento e transformação da sociedade. A concepção de Ensino Médio Técnico-Integrado nos parece orientar-se antes para a formação “integral” do cidadão, da pessoa em sua totalidade. O trabalho não é apenas uma relação econômica, mas também ética, política e estética. Deve ser uma forma de realização, de humanização do mundo, e não de coisificação do homem. É sempre possível pensar nossos espaços de educação formal como um compartilhar humano de sentidos, de afetos, de vivências, de posturas, de identidades. A esses espaços deverá a qualificação técnica sempre agregar-se, jamais sobrepor-se.

  11. Quando a instituição escolar contribui para a violência: um olhar sobre os portadores de transtornos de aprendizagem

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    Maria Lúcia Moreira Gomes

    2012-10-01

    Full Text Available Falar sobre violência na escola parece investir em assunto corriqueiro e com ares de modernidade, atribuindo a esta o sentido de um problema que se agiganta. No entanto, podemos afirmar que a escola não está dando conta de seus alunos reais porque ela continua sendo a escola ideal para alunos ideais. Estudos comprovam que as dificuldades de aprendizagem trazem em seu bojo, no caso específico dos transtornos de aprendizagem, um fator importante a ser considerado que é o desconhecimento do assunto por parte dos educadores. Este fato, aliado a situações de bulling, é, comprovadamente, um dos fatores desencadeadores da violência escolar.

  12. Gene expression in the muscle and central nervous system following intramuscular inoculation of encapsidated or naked poliovirus replicons

    International Nuclear Information System (INIS)

    Jackson, Cheryl A.; Messinger, Jeff; Palmer, Matthew T.; Peduzzi, Jean D.; Morrow, Casey D.

    2003-01-01

    The spread of intramuscularly inoculated poliovirus to the central nervous system (CNS) has been documented in humans, monkeys, and mice transgenic for the human poliovirus receptor. Poliovirus spread is thought to be due to infection of the peripheral nerve and retrograde transport of poliovirus through the axon to the neuron cell body, where final virus uncoating occurs and translation/replication ensues. In previous studies, we have shown that polio-based vectors (replicons) can be used for gene delivery to motor neurons of the CNS. Using a replicon that encodes green fluorescent protein (GFP), we found that following intrathecal inoculation, GFP expression was confined to motorneurons of the spinal cord. To further characterize the gene expression of poliovirus in the periphery and CNS, we have intramuscularly inoculated transgenic mice with poliovirus replicons encoding GFP. Expression of GFP was demonstrated in the muscle, sciatic nerve, dorsal root ganglion, and the ventral horn motorneurons following intramuscular inoculation. There was no evidence of paralysis or behavioral abnormalities in the mice following intramuscular inoculation of the replicon encoding GFP. Injection of replicon RNA alone (naked RNA) into the muscle of transgenic mice or rats, which do not express the poliovirus receptor, also resulted in expression of GFP in the muscle, sciatic nerve, dorsal root ganglion, and ventral horn motorneurons, indicating that transport of the replicon RNA from the periphery to CNS had occurred. GFP expression was found in the muscles and sciatic nerve as early as 6 h after injection of replicons or replicon RNA, even after sciatic nerve section. Analysis at longer times postinjection revealed GFP expression similar to 6 h levels in the cut sciatic nerves and robust expression in the nerves of uncut animals. The infection and expression of GFP in the CNS following intramuscular inoculation of encapsidated replicons encoding GFP occurred in juvenile or

  13. O operar de um coletivo na WEB

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    Karen Eidelwein

    Full Text Available Analisamos o operar de um grupo de discussão na WEB buscando identificar seu agenciamento enquanto coletivo autoprodutivo. Estabelecemos sete indicadores de operação e cinco categorias temáticas. A visualização de cada um dos indicadores de operação em cada uma das categorias temáticas possibilitou compreender o operar do grupo como decorrente das próprias relações que foram sendo estabelecidas, em um processo autoprodutivo, de causalidade recursiva. Foi possível argumentar que o grupo apresentou indícios de um modo de instituir-se capaz de apontar para outras formas de relação em torno da construção de objetos coletivos teóricos voltados para a ação fora do espaço digital.

  14. Umělá inteligence

    OpenAIRE

    Ragas, Luděk

    2017-01-01

    Cílem této bakalářské práce je poskytnout náhled do rozsáhlého oboru umělé inteligence. Téze nejprve poskytuje definici umělé inteligence a krátký přehled její historie. Poté práce stručně popisuje technologie umělé inteligence, jako jsou neuronové sítě, expertní systémy a genetické algoritmy. Na závěr téze popisuje vliv umělé inteligence na společnost a její pozici v ní. The aim of this bachelor thesis is to provide insight into the extensive field of artificial intelligence. At first, th...

  15. Meninos, eu vi e ouvi! (Um depoimento)

    OpenAIRE

    Trinta, Aluizio Ramos

    2004-01-01

    Herbert Marshall McLuhan e o Centro para a Cultura e a Tecnologia da Universidade de Toronto (Canadá). Origens artísticas, literárias e filosóficas do mcluhanismo (ou do "mcluhnatismo", segundo adversários). Memórias de um jovem professor brasileiro: conhecendo um Mestre. Anotações filológicas acerca dos modos de pensar, escrever e dizer de Herbert Marshall McLuhan.

  16. Forma de heidenhain da doença de creutzfeldt-jakob: relato de um caso

    Directory of Open Access Journals (Sweden)

    Luciano Ribeiro Pinto Junior

    1986-03-01

    Full Text Available Registro de um caso da doença de Creutzfeldt-Jakob, forma de Heidenhain, que se caracteriza por comprometimento visual importante. As manifestações iniciais consistiram de distúrbios visuais. A paciente evoluiu para franca demência, ao lado de manifestações pirâmido-extrapiramidais. Além dos dados clínicos o EEG mostrou atividade periódica característica da doença. O estudo anátomo-patológico confirmou o diagnóstico clínico mostrando alteração esponjosa, degeneração neuronal e astrogliose. Além do quadro clínico, eletrencefalográfico e anátomo-patológico são discutidos os aspectos etiopatogênicos da doença.

  17. DIVERSIDADE DE LEPIDOPTERA EM UM FRAGMENTO FLORESTAL EM MUZAMBINHO, MINAS GERAIS

    OpenAIRE

    Andrade, Dirlene Aparecida de; Teixeira, Isabel Ribeiro do Valle

    2017-01-01

    RESUMO O monitoramento de populações de Lepidoptera fornece informações importantes para avaliar a dinâmica e as mudanças ecológicas nos ecossistemas. Neste trabalho avaliou-se e caracterizou-se a Lepidofauna da mata do IFSULDEMINAS - Campus Muzambinho - MG, estabelecendo um padrão para inúmeros fragmentos semelhantes na região. Em 12 meses de levantamento foram capturados 590 indivíduos de 69 espécies, distribuídas em 10 famílias. A família mais abundante foi Nymphalidae (73,56% dos indivídu...

  18. Astrocitoma frontal com metastase medular: registro de um caso e revisão da literatura

    Directory of Open Access Journals (Sweden)

    J. Jorge Facure

    1978-12-01

    Full Text Available Relato de um caso de astrocitoma grau II com metástase medular ao nível da terceira vértebra dorsal. O nódulo intradural determinou sinais e sintomas de compressão medular. O diagnóstico clínico foi confirmado por mielografia descendente com lipiodol e mielocintilografia com I131 - albumina. A paciente foi submetida a laminectomia para exerese da metástase. A revisão da literatura mostra que o fator mais importante para a ocorrência das metástase dos tumores encefálicos é a invasão do sistema ventricular e/ou espaço subaracnóideo periencefálico pela neoplasia, sem relação com o ato operatório.

  19. The optimal choice of medication administration route regarding intravenous, intramuscular, and subcutaneous injection

    Directory of Open Access Journals (Sweden)

    Jin JF

    2015-07-01

    Full Text Available Jing-fen Jin,1 Ling-ling Zhu,2 Meng Chen,3 Hui-min Xu,3 Hua-fen Wang,1 Xiu-qin Feng,1 Xiu-ping Zhu,3 Quan Zhou31Division of Nursing, 2VIP Care Ward, Division of Nursing, 3Department of Pharmacy, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of ChinaBackground: Intravenous (IV, intramuscular (IM, and subcutaneous (SC are the three most frequently used injection routes in medication administration. Comparative studies of SC versus IV, IM versus IV, or IM versus SC have been sporadically conducted, and some new findings are completely different from the dosage recommendation as described in prescribing information. However, clinicians may still be ignorant of such new evidence-based findings when choosing treatment methods.Methods: A literature search was performed using PubMed, MEDLINE, and Web of Sciences™ Core Collection to analyze the advantages and disadvantages of SC, IV, and IM administration in head-to-head comparative studies.Results: “SC better than IV” involves trastuzumab, rituximab, antitumor necrosis factor medications, bortezomib, amifostine, recombinant human granulocyte-macrophage colony-stimulating factor, granulocyte colony-stimulating factor, recombinant interleukin-2, immunoglobulin, epoetin alfa, heparin, and opioids. “IV better than SC” involves ketamine, vitamin K1, and abatacept. With respect to insulin and ketamine, whether IV has advantages over SC is determined by specific clinical circumstances. “IM better than IV” involves epinephrine, hepatitis B immunoglobulin, pegaspargase, and some antibiotics. “IV better than IM” involves ketamine, morphine, and antivenom. “IM better than SC” involves epinephrine. “SC better than IM” involves interferon-beta-1a, methotrexate, human chorionic gonadotropin, hepatitis B immunoglobulin, hydrocortisone, and morphine. Safety, efficacy, patient preference, and pharmacoeconomics are four principles

  20. EDUCAÇÃO E SOFRIMENTO: MARCAS DE UM PARADIGMA

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    Nize Campos Pellanda

    2008-07-01

    Full Text Available Com essa comunicação pretendemos apresentar um relato de uma pesquisa em andamento sobre sofrimento dos estudantes como consequência de práticas educativas que não contemplam necessidades fundamentais dos seres humanos em termos biológicos, epistêmicos e ontológicos. Essas necessidades estão sendo apontadas por pesquisas transdisciplinares recentes sobre o funcionamento dos seres vivos. Essas práticas didáticas são consideradas na pesquisa como altamente inibidoras do ser/conhecer. Essa inseparabilidade das dimensões da realidade é a marca principal da investigação pautada no paradigma da complexidade fazendo contraponto com as questões da fragmentação da modernidade que representam um foco importante de análise. O quadro teórico de fundo para análise dos dados é construído a partir de ciências que constituem o movimento de auto-organização (MAO focalizando principalmente as teorias biológico/cognitivas da Biologia do Conhecer de H. Maturana e F. Varela e Complexificação pelo ruído de H. Atlan. Os dados referem-se a duas fontes principais de coleta: conversas com crianças de 5ª a 8ª séries do Ensino Fundamental de escolas estaduais de duas cidades diferentes e depoimentos de educadores em forma de história de vida. Nessa apresentação serão discutidos apenas os dados referentes à primeira parte pois a segunda parte ainda não foi analisada. Esclarecemos que trata-se de uma pesquisa em andamento e, por esse motivo, não aparecerão aqui situações conclusivas mas sim uma ênfase no devir da pesquisa. A partir desse quadro teórico, são feitas as análises cujo eixo situa-se na questão da (nãoconstrução de sentido na escola. Usamos sentido como aquilo que emerge da ação humana e, portanto, como produção dos seres humanos no bojo de sua ação sobre a realidade. Nessa perspectiva, ele faz parte integrante do processo de conhecimento que, por sua vez, não se separa do processo de viver. Palavras

  1. Relationship between medical compression and intramuscular pressure as an explanation of a compression paradox.

    Science.gov (United States)

    Uhl, J-F; Benigni, J-P; Cornu-Thenard, A; Fournier, J; Blin, E

    2015-06-01

    Using standing magnetic resonance imaging (MRI), we recently showed that medical compression, providing an interface pressure (IP) of 22 mmHg, significantly compressed the deep veins of the leg but not, paradoxically, superficial varicose veins. To provide an explanation for this compression paradox by studying the correlation between the IP exerted by medical compression and intramuscular pressure (IMP). In 10 legs of five healthy subjects, we studied the effects of different IPs on the IMP of the medial gastrocnemius muscle. The IP produced by a cuff manometer was verified by a Picopress® device. The IMP was measured with a 21G needle connected to a manometer. Pressure data were recorded in the prone and standing positions with cuff manometer pressures from 0 to 50 mmHg. In the prone position, an IP of less than 20 did not significantly change the IMP. On the contrary, a perfect linear correlation with the IMP (r = 0.99) was observed with an IP from 20 to 50 mmHg. We found the same correlation in the standing position. We found that an IP of 22 mmHg produced a significant IMP increase from 32 to 54 mmHg, in the standing position. At the same time, the subcutaneous pressure is only provided by the compression device, on healthy subjects. In other words, the subcutaneous pressure plus the IP is only a little higher than 22 mmHg-a pressure which is too low to reduce the caliber of the superficial veins. This is in accordance with our standing MRI 3D anatomical study which showed that, paradoxically, when applying low pressures (IP), the deep veins are compressed while the superficial veins are not. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  2. Pharmacokinetics of a new diclofenac sodium formulation developed for subcutaneous and intramuscular administration.

    Science.gov (United States)

    Zeitlinger, Markus; Rusca, Antonio; Oraha, Alhan Z; Gugliotta, Barbara; Müller, Markus; Ducharme, Murray P

    2012-06-01

    To assess the relative bioavailability of diclofenac sodium hydroxypropyl β-cyclodextrin (HPβCD) administered via the subcutaneous (s.c.) and intramuscular (i.m.) route versus Voltaren® i.m. and to evaluate the dose linearity and pharmacokinetics of the s.c. formulation at three dose levels. Safety and local tolerability were also assessed. One single-dose, randomized, three-way, crossover relative bioavailability study and one linearity single escalating dose, randomized, three-way cross-over pharmacokinetic study were conducted at two different clinical sites. A total of 42 healthy male and female subjects participated in both studies. Subjects received 75 mg/ml diclofenac sodium HPβCD (i.m. and s.c.) and Voltaren® 75 mg/3 ml (i.m.) in Study 1 and 25, 50, or 75 mg/ml diclofenac sodium HPβCD (s.c.) in Study 2. Study 1 demonstrated bioequivalence of the s.c. test formulation with Voltaren® i.m. with respect to Cmax and AUC. Bioequivalence of the test i.m. with Voltaren® i.m. was also demonstrated (except the upper limit of the 90% confidence interval (CI) for Cmax which marginally exceeded the 80 - 125% range (125.78%)). Study 2 demonstrated that after s.c. administration of the test formulation, both Cmax and AUC are linearly related to the tested diclofenac doses. All tested doses were safe and locally well-tolerated with no serious adverse events reported. Bioequivalence of diclofenac HPβCD 75 mg/ml after s.c. and i.m. administration with Voltaren® i.m. was demonstrated, except for the marginal deviation in Cmax when comparing the i.m. test and Voltaren®. Linearity was also demonstrated for the three doses intended for marketing.

  3. Intramuscular ziprasidone versus haloperidol for managing agitation in Chinese patients with schizophrenia.

    Science.gov (United States)

    Zhang, Hongyan; Wang, Gang; Zhao, Jingping; Xie, Shiping; Xu, Xiufeng; Shi, Jianguo; Deng, Hehuang; Li, Keqing; Gao, Chengge; Wang, Xiaoping; Vanderburg, Douglas; Pan, Sharon; Tang, Haiyun; Shu, Liang; Karayal, Onur N

    2013-04-01

    Intramuscular (IM) antipsychotics are preferred for efficient control of agitation symptoms. Previous studies have demonstrated that IM ziprasidone is efficacious and safe for treatment of agitation in schizophrenia. However, clinicians now recognize that racial differences may contribute to altered therapeutic response and tolerability. This study compared the efficacy and tolerability of IM ziprasidone versus IM haloperidol for the management of agitation in Chinese subjects with schizophrenia. Subjects with acute schizophrenia were randomized to either ziprasidone (n = 189, 10 to 20 mg as required up to a maximum of 40 mg/d) or haloperidol (n = 187, 5 mg every 4 to 8 hours to a maximum of 20 mg/d) for 3 days. Psychiatric assessments and adverse events were assessed at baseline, 2, 4, 24, 48, and 72 hours. In the ziprasidone group, 2.1% of subjects discontinued versus 3.7% in the haloperidol group. The least squares mean change (SE) from baseline to 72 hours in Brief Psychiatry Rating Scale total score was -17.32 (0.7) for ziprasidone (n = 167) and -18.44 (0.7) for haloperidol (n = 152), with a 95% confidence interval treatment difference of -0.7 to 2.9. Fewer subjects experienced adverse events after ziprasidone (n = 54, 28.6%) than haloperidol (n = 116, 62.0%), with a notably higher incidence of extrapyramidal symptoms in the haloperidol group (n = 69, 36.9%) compared to the ziprasidone group (n = 4, 2.1%). For controlling agitation in schizophrenia in this Chinese study, ziprasidone had a favorable tolerability profile and comparable efficacy and safety compared to haloperidol.

  4. Fatty Acids Profile of Intramuscular Fat in Light Lambs Traditionally and Artificially Reared

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    Milan MARGETÍN

    2014-03-01

    Full Text Available The quality of 40 carcasses of light lambs of the synthetic population of Slovak Dairy sheep from (a artificial rearing (AR and (b traditional rearing (TR was assessed on the basis of fatty acids profile of intramuscular fat (IMF. Lambs from AR in comparison with TR were of lower quality as assessed on the basis of fatty acids (FAs profile. The content of conjugated linolic acid (CLA in the fat of TR lambs was severalfold higher (0.749 vs. 0.193 g.100g-1 FAME, P<0.001 than in AR lambs. Similarly, the content of trans-vaccenic (TVA, á-linolenic (ALA, rumenic (RA, eicosapentaenoic (EPA and docosahexaenoic acid (DHA was in TR lambs significantly higher (P<0.001 than in AR lambs (0.955 vs. 0.111; 0.715 vs. 0.251; 0.672 vs. 0.148; 0.352 vs. 0.061; 0.252 vs. 0.079 g.100g-1 FAME. In contrary, the content of linoleic acid (LA, the ratio of LA/ALA and n-6/n-3 in AR lambs was higher than in TR lambs (9.07 vs. 4.81 g.100 g-1 FAME; 39.11 vs. 6.80; 14.56 vs. 3.25, P<0.001. In TR lambs the content of n-3 PUFA and BCFA was significantly higher (P<0.001 than in AR lambs (2.08 vs. 0.84 and 1.95 vs. 0.45. The value of thrombogenic index was higher in AR lambs in comparison with TR lambs (1.44 vs. 1.31; P<0.05. Significant differences between FAs of IMF of ram lambs and ewe lambs were observed only in the case of arachidonic acid (P<0.05.

  5. Metabolism of [14C]Cefmenoxime in normal subjects after intramuscular administration

    International Nuclear Information System (INIS)

    Machinist, J.M.; Bopp, B.A.; Quinn, D.

    1984-01-01

    The metabolism of cefmenoxime (SCE-1365) was studied in four healthy male volunteers after intramuscular administration of a single 500-mg dose of the 14C-labeled drug. Plasma levels of total radioactivity and cefmenoxime peaked at 0.5 and 1.0 h, corresponding to 16.5 micrograms eq/ml and 15.8 micrograms/ml, respectively. Thereafter, parent drug levels declined rapidly, with a terminal elimination half-life of ca. 1.5 h. No significant differences were noted between total radioactivity and parent drug levels up to 2 h after drug administration. After 3 h, low but persistent levels of radioactivity were significantly greater than parent drug levels, indicating metabolism or degradation of cefmenoxime. The terminal elimination half-life of total radioactivity was estimated to be ca. 40 h. The radioactive plasma metabolite(s) remaining at the end of the 5-day study represented only 1% of the administered dose. Urinary excretion was the major route of elimination of cefmenoxime, accounting for ca. 86% of the dose in 12 h. Analysis of cefmenoxime in urine by total radioactivity, high-pressure liquid chromatography, and a microbiological assay showed that 80 to 92% of the excreted dose was parent drug. Radioactivity was also excreted into the feces via the bile and represented ca. 11% of the dose after 5 days. Although extensive degradation of cefmenoxime was found in fecal samples, it was proposed that this may be due to the metabolic activity of the intestinal flora rather than in vivo biotransformation in the liver. This study supports the concept that cefmenoxime undergoes minimal metabolism in humans and is excreted largely as unchanged drug

  6. Hemato-Biochemical Effects of Colistin Administered Intramuscularly in Growing Broiler Birds

    Directory of Open Access Journals (Sweden)

    Muhammad Kashif Saleemi

    2014-01-01

    Full Text Available The current study was designed to probe pathological effects of colistin in growing broilers. One hundred twenty day-old broiler chicks were divided into six equal groups A-F. These birds were injected colistin sulphate, 0, 5, 10, 20, 40 and 80 mg/kg BW respectively through intramuscular route. The different serum-biochemical parameters including total protein, albumen, globulin, ALT, AST, LDH, GGT, creatinine and BUN were determined at day 21 and 42 of experiment. The hematological parameters including RBC, WBC, PCV and Hb were determined twice. The serum total protein values were significantly higher in group E as compared with control group. At day 42 groups, C-E had significantly lower albumen values as compared to group A. The similar pattern was observed in globulin values. The creatinine & urea was also found significantly higher in group D and E at day 21 of experiment, while at day 42 all the groups having significantly higher urea level in comparison with group A indicating nephrotoxic effect of colistin. The serum enzymes including ALT and AST were significantly higher in group D & E as compared with group A, which is an indication of liver damage. The LDH and GGT values showed significantly increasing trend in experimental groups compared with control. The erythrocytes and leucocytes count were significantly higher in control and low dose groups as compared with higher colistin dose groups. It is concluded that lavish parenteral administration of colistin resulted in increased levels of hepato-renal serum indicators and lower values of hematological parameters.

  7. Sedative and antinociceptive effects of dexmedetomidine and buprenorphine after oral transmucosal or intramuscular administration in cats.

    Science.gov (United States)

    Porters, Nathalie; Bosmans, Tim; Debille, Mariëlla; de Rooster, Hilde; Duchateau, Luc; Polis, Ingeborgh

    2014-01-01

    To compare sedation and antinociception after oral transmucosal (OTM) and intramuscular (IM) administration of a dexmedetomidine-buprenorphine combination in healthy adult cats. Randomized, 'blinded' crossover study, with 1 month washout between treatments. Six healthy neutered female cats, weighing 5.3-7.5 kg. A combination of dexmedetomidine (40 μg kg(-1) ) and buprenorphine (20 μg kg(-1) ) was administered by either the OTM (buccal cavity) or IM (quadriceps muscle) route. Sedation was measured using a numerical rating scale, at baseline and at various time points until 6 hours after treatment. At the same time points, analgesia was scored using a dynamic and interactive visual analogue scale, based on the response to an ear pinch, and by the cat's response to a mechanical stimulus exerted by a pressure rate onset device. Physiological and adverse effects were recorded, and oral pH measured. Signed rank tests were performed, with significance set at p < 0.05. Data are presented as median and range. There were no differences in sedation or antinociception scores between OTM and IM dosing at any of the time points. Nociceptive thresholds increased after both treatments but without significant difference between groups. Buccal pH remained between 8 and 8.5. Salivation was noted after OTM administration (n = 2) and vomiting after both OTM (n = 4), and IM (n = 3) dosing. In healthy adult cats, OTM administration of dexmedetomidine and buprenorphine resulted in comparable levels of sedation and antinociception to IM dosing. The OTM administration may offer an alternative route to administer this sedative-analgesic combination in cats. © 2013 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia.

  8. Efficacy of Sublingual Misoprostol versus Intramuscular Methylergometrine in Prevention of Primary Postpartum Hemorrhage

    International Nuclear Information System (INIS)

    Anwar, R.; Ambreen, A.; Khuram, A.; Mushtaq, M.

    2013-01-01

    Post partum hemorrhage still remains a major cause of maternal morbidity and mortality in developing countries. Most of oxytocics like methylergometrine require parenteral administration, which requires special storage. Misoprostol is thermo stable, has a long shelf life and is widely recommended for prevention of postpartum hemorrhage. This can be a choice of oxytocic in developing countries like ours, where storage facilities and resources are limited. Objectives: To compare efficacy of sublingual Misoprostol versus intramuscular Methylergometrine in prevention of primary postpartum hemorrhage after delivery. Study Design: Quasi experimental study Place and Duration of Study: Department of Gynae/Obs, Military Hospital and Combined Military Hospital Rawalpindi cantt. December 2007 to July 2008. Material and Methods: One hundred and thirty six pregnant ladies were selected. On arrival each patient was examined thoroughly along with baseline investigations. Therapeutic option was allocated to the patients simply by using a table of random numbers and dividing them in two equal groups. Informed written consent was taken. Each patient was observed for blood loss estimation and hematocrit drop. All the data was analyzed using SPSS version 10.0. Mean +- SD for age, pre-delivery and post-delivery hematocrit, percentage of drop in hematocrit and blood loss during labour was calculated. Results: Mean drop of hematocrit and blood loss were compared among two groups. At the end, it was revealed that there was no significant difference among two groups in blood loss (p=0.49) and hematocrit drop (p=0.14). Conclusion: There is no significant better effect in preventing post partum hemorrhage among the two drugs. (author)

  9. Depletion of long-acting ampicillin in goat milk following intramuscular administration.

    Science.gov (United States)

    Ferrini, Anna Maria; Trenta, Simona; Mannoni, Veruscka; Rosati, Remo; Coni, Ettore

    2010-12-08

    Although goat milk production represents today a very small percentage of the world milk market, this percentage has been growing continuously during the past 20 years. Goat milk is the basic milk supply in many developing countries and provides tasteful derivative products in developed countries. Goats, as well as all milk-producing animals, can be affected by mastitis, but goats being considered a minor species, few drugs are specifically registered for these animals; most, at least for mastitis treatment, are usually tested and registered for use in cows. This situation leads often to the adoption for goat milk of withdrawal periods defined for cows even if these extrapolations prove almost never valid for goats. In the present study, the elimination of the β-lactam antibacterial agent ampicillin in goat milk was investigated. Ampicillin was chosen because it is one of the most common antibiotics used by goat farmers against mastitis due to the fact that it is well tolerated and has short elimination times in cows. Goats were treated with long-acting ampicillin at 15 mg (kg of body weight)(-1) by double intramuscular injection at 72 h interval. Milk was collected in a 12 h milking scheme. The method used to determine the levels of ampicillin in goat milk was based on a liquid-liquid extraction of this drug from the matrix, successive derivatization with formaldehyde, and final separation by HPLC with fluorescence detection. The results point out a slow depletion of ampicillin and, consequently, a withdrawal period (13 milkings) longer than that extrapolated and authorized for cows and sheep.

  10. The impact of a standardised intramuscular sedation protocol for acute behavioural disturbance in the emergency department

    Directory of Open Access Journals (Sweden)

    Downes Michael A

    2010-06-01

    Full Text Available Abstract Background Acute behavioural disturbance (ABD is an increasing problem in emergency departments. This study aimed to determine the impact of a structured intramuscular (IM sedation protocol on the duration of ABD in the emergency department. Methods A historical control study was undertaken comparing 58 patients who required physical restraint and parenteral sedation with the structured IM sedation protocol, to 73 historical controls treated predominantly by intravenous sedation, according to individual clinician preference. The primary outcome was the duration of the ABD defined as the time security staff were required. Secondary outcomes were the requirement for additional sedation, drug related-adverse effects and patient and staff injuries. Results The median duration of the ABD in patients with the new sedation protocol was 21 minutes (IQR: 15 to 35 minutes; Range: 5 to 78 minutes compared to a median duration of 30 minutes (IQR: 15 to 50 minutes; Range: 5 to 135 minutes in the historical controls which was significantly different (p = 0.03. With IM sedation only 27 of 58 patients (47%; 95% CI: 34% to 60% required further sedation compared to 64 of 73 historical controls (88%; 95%CI: 77% to 94%. There were six (10% drug-related adverse events with the new IM protocol [oxygen desaturation (5, oxygen desaturation/airway obstruction (1] compared to 10 (14% in the historical controls [oxygen desaturation (5, hypoventilation (4 and aspiration (1]. Injuries to staff occurred with three patients using the new sedation protocol and in seven of the historical controls. Two patients were injured during the new protocol and two of the historical controls. Conclusion The use of a standardised IM sedation protocol was simple, more effective and as safe for management of ABD compared to predominantly intravenous sedation.

  11. Umbilical cord mesenchyme stem cell local intramuscular injection for treatment of uterine niche

    Science.gov (United States)

    Fan, Dazhi; Wu, Shuzhen; Ye, Shaoxin; Wang, Wen; Guo, Xiaoling; Liu, Zhengping

    2017-01-01

    Abstract Background: Uterine niche is defined as a triangular anechoic structure at the site of the scar or a gap in the myometrium at the site of a previous caesarean section. The main clinical manifestations are postmenstrual spotting and intrauterine infection, which may seriously affect the daily life of nonpregnant women. Trials have shown an excellent safety and efficacy for the potential of mesenchymal stem cells (MSCs) as a therapeutic option for scar reconstruction. Therefore, this study is designed to investigate the safety and efficacy of using MSCs in the treatment for the uterine niche. Methods/design: This phase II clinical trial is a single-center, prospective, randomized, double-blind, placebo-controlled with 2 arms. One hundred twenty primiparous participants will be randomly (1:1 ratio) assigned to receive direct intramuscular injection of MSCs (a dose of 1∗107 cells in 1 mL of 0.9% saline) (MSCs group) or an identical-appearing 1 mL of 0.9% saline (placebo-controlled group) near the uterine incision. The primary outcome of this trial is to evaluate the proportion of participants at 6 months who is found uterine niche in the uterus by transvaginal utrasonography. Adverse events will be documented in a case report form. The study will be conducted at the Department of Obstetric of Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan. Discussion: This trial is the first investigation of the potential for therapeutic use of MSCs for the management of uterine niche after cesarean delivery. Conclusion: This protocol will help to determine the efficacy and safety of MSCs treatment in uterine niche and bridge the gap with regards to the current preclinical and clinical evidence. Trial registration number: NCT02968459 (Clinical Trials.gov: http://clinicaltrials.gov/). PMID:29095305

  12. Lack of gender effect on the pharmacokinetics of oxytetracycline in Fenneropenaeus chinensis after intramuscular administration

    Science.gov (United States)

    Sun, Ming; Li, Jian; Chang, Zhiqiang; Guo, Wenting; Zhao, Fazhen; Li, Jitao

    2015-04-01

    Fenneropenaeus chinensis, an economically important shrimp species, currently suffers from epizootic diseases due to high density stocking and bacterial infections. Oxytetracycline (OTC) has been widely used to treat various systemic bacterial infections in shrimp farming. In the present study, the effect of gender on pharmacokinetics of OTC in F. chinensis was investigated. The OTC concentrations in hemolymph of shrimp after single intramuscular administration (75 mg OTC per kg body weight) were analyzed by high performance liquid chromatography and best described with a two-compartment open model which is characterized by a short elimination half-life, low clearance, and a relatively large apparent volume of distribution. The pharmacokinetic equations were C t = 58.54e-0.38 t + 11.67e-0.04 t for females; and C t = 27.94e-0.28 t + 14.87e-0.04 t for males. The distribution and elimination half-lives of OTC were 1.82 and 19.58 h, respectively, in females and 2.50 and 16.11 h, respectively, in males at 22°C. The areas under the drug concentration curve were 480 mg L-1 h-1 in females and 430 mg L-1 h-1 in males. The total body clearance of the drug was 157.11 mL kg-1 h-1 in females and 172.47 mL kg-1 h-1 in males. The apparent volume distribution was 4.44 in females and 4.01 L kg-1 in males. There was no significant difference in pharmacokinetic parameters between female and male shrimps, indicating that there is no need to consider the gender effect in clinical use of OTC in F. chinensis farming.

  13. Artesunate Suppositories versus Intramuscular Artemether for Treatment of Severe Malaria in Children in Papua New Guinea

    Science.gov (United States)

    Karunajeewa, Harin A.; Reeder, John; Lorry, Kerry; Dabod, Elizah; Hamzah, Juliana; Page-Sharp, Madhu; Chiswell, Gregory M.; Ilett, Kenneth F.; Davis, Timothy M. E.

    2006-01-01

    Drug treatment of severe malaria must be rapidly effective. Suppositories may be valuable for childhood malaria when circumstances prevent oral or parenteral therapy. We compared artesunate suppositories (n = 41; 8 to 16 mg/kg of body weight at 0 and 12 h and then daily) with intramuscular (i.m.) artemether (n = 38; 3.2 mg/kg at 0 h and then 1.6 mg/kg daily) in an open-label, randomized trial with children with severe Plasmodium falciparum malaria in Papua New Guinea (PNG). Parasite density and temperature were measured every 6 h for ≥72 h. Primary endpoints included times to 50% and 90% parasite clearance (PCT50 and PCT90) and the time to per os status. In a subset of 29 patients, plasma levels of artemether, artesunate, and their common active metabolite dihydroartemisinin were measured during the first 12 h. One suppository-treated patient with multiple complications died within 2 h of admission, but the remaining 78 recovered uneventfully. Compared to the artemether-treated children, those receiving artesunate suppositories had a significantly earlier mean PCT50 (9.1 versus 13.8 h; P = 0.008) and PCT90 (15.6 versus 20.4 h; P = 0.011). Mean time to per os status was similar for each group. Plasma concentrations of primary drug plus active metabolite were significantly higher in the artesunate suppository group at 2 h postdose. The earlier initial fall in parasitemia with artesunate is clinically advantageous and mirrors higher initial plasma concentrations of active drug/metabolite. In severely ill children with malaria in PNG, artesunate suppositories were at least as effective as i.m. artemether and may, therefore, be useful in settings where parenteral therapy cannot be given. PMID:16495259

  14. Artesunate suppositories versus intramuscular artemether for treatment of severe malaria in children in Papua New Guinea.

    Science.gov (United States)

    Karunajeewa, Harin A; Reeder, John; Lorry, Kerry; Dabod, Elizah; Hamzah, Juliana; Page-Sharp, Madhu; Chiswell, Gregory M; Ilett, Kenneth F; Davis, Timothy M E

    2006-03-01

    Drug treatment of severe malaria must be rapidly effective. Suppositories may be valuable for childhood malaria when circumstances prevent oral or parenteral therapy. We compared artesunate suppositories (n = 41; 8 to 16 mg/kg of body weight at 0 and 12 h and then daily) with intramuscular (i.m.) artemether (n = 38; 3.2 mg/kg at 0 h and then 1.6 mg/kg daily) in an open-label, randomized trial with children with severe Plasmodium falciparum malaria in Papua New Guinea (PNG). Parasite density and temperature were measured every 6 h for > or = 72 h. Primary endpoints included times to 50% and 90% parasite clearance (PCT50 and PCT90) and the time to per os status. In a subset of 29 patients, plasma levels of artemether, artesunate, and their common active metabolite dihydroartemisinin were measured during the first 12 h. One suppository-treated patient with multiple complications died within 2 h of admission, but the remaining 78 recovered uneventfully. Compared to the artemether-treated children, those receiving artesunate suppositories had a significantly earlier mean PCT50 (9.1 versus 13.8 h; P = 0.008) and PCT90 (15.6 versus 20.4 h; P = 0.011). Mean time to per os status was similar for each group. Plasma concentrations of primary drug plus active metabolite were significantly higher in the artesunate suppository group at 2 h postdose. The earlier initial fall in parasitemia with artesunate is clinically advantageous and mirrors higher initial plasma concentrations of active drug/metabolite. In severely ill children with malaria in PNG, artesunate suppositories were at least as effective as i.m. artemether and may, therefore, be useful in settings where parenteral therapy cannot be given.

  15. Intramuscular injection of alfaxalone in combination with butorphanol for sedation in cats.

    Science.gov (United States)

    Deutsch, Julia; Jolliffe, Colette; Archer, Emma; Leece, Elizabeth A

    2017-07-01

    To assess quality of sedation following intramuscular (IM) injection of two doses of alfaxalone in combination with butorphanol in cats. Prospective, randomized, 'blinded' clinical study. A total of 38 cats undergoing diagnostic imaging or noninvasive procedures. Cats were allocated randomly to be administered butorphanol 0.2 mg kg -1 combined with alfaxalone 2 mg kg -1 (group AB2) or 5 mg kg -1 (group AB5) IM. If sedation was inadequate, alfaxalone 2 mg kg -1 IM was administered and cats were excluded from further analysis. Temperament [1 (friendly) to 5 (aggressive)], response to injection, sedation score at 2, 6, 8, 15, 20, 30, 40, 50 and 60 minutes, overall sedation quality scored after data collection [1 (excellent) to 4 (inadequate)] and recovery quality were assessed. Heart rate (HR), respiratory rate (f R ) and arterial haemoglobin saturation (SpO 2 ) were recorded every 5 minutes. Groups were compared using t tests and Mann-Whitney U tests. Sedation was analysed using two-way anova, and additional alfaxalone using Fisher's exact test (p cats in AB2 and two in AB5 (p = 0.005). Recovery quality, HR, f R and SpO 2 were similar. Seven cats required oxygen supplementation. Complete recovery times were shorter in AB2 (81.8 ± 24.3 versus 126.6 ± 33.3 minutes; p = 0.009). Twitching was the most common adverse event. In combination with butorphanol, IM alfaxalone at 5 mg kg -1 provided better quality sedation than 2 mg kg -1 . Monitoring of SpO 2 is recommended. Copyright © 2017 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.

  16. The pharmacological effects of the anesthetic alfaxalone after intramuscular administration to dogs.

    Science.gov (United States)

    Tamura, Jun; Ishizuka, Tomohito; Fukui, Sho; Oyama, Norihiko; Kawase, Kodai; Miyoshi, Kenjiro; Sano, Tadashi; Pasloske, Kirby; Yamashita, Kazuto

    2015-03-01

    The pharmacological effects of the anesthetic alfaxalone were evaluated after intramuscular (IM) administration to 6 healthy beagle dogs. The dogs received three IM doses each of alfaxalone at increasing dose rates of 5 mg/kg (IM5), 7.5 mg/kg (IM7.5) and 10 mg/kg (IM10) every other day. Anesthetic effect was subjectively evaluated by using an ordinal scoring system to determine the degree of neuro-depression and the quality of anesthetic induction and recovery from anesthesia. Cardiorespiratory variables were measured using noninvasive methods. Alfaxalone administered IM produced dose-dependent neuro-depression and lateral recumbency (i.e., 36 ± 28 min, 87 ± 26 min and 115 ± 29 min after the IM5, IM7.5 and IM10 treatments, respectively). The endotracheal tube was tolerated in all dogs for 46 ± 20 and 58 ± 21 min after the IM7.5 and IM10 treatments, respectively. It was not possible to place endotracheal tubes in 5 of the 6 dogs after the IM5 treatment. Most cardiorespiratory variables remained within clinically acceptable ranges, but hypoxemia was observed by pulse oximetry for 5 to 10 min in 2 dogs receiving the IM10 treatment. Dose-dependent decreases in rectal temperature, respiratory rate and arterial blood pressure also occurred. The quality of recovery was considered satisfactory in all dogs receiving each treatment; all the dog exhibited transient muscular tremors and staggering gait. In conclusion, IM alfaxalone produced a dose-dependent anesthetic effect with relatively mild cardiorespiratory depression in dogs. However, hypoxemia may occur at higher IM doses of alfaxalone.

  17. Pharmacokinetics and tissue distribution of enrofloxacin after single intramuscular injection in Pacific white shrimp.

    Science.gov (United States)

    Fang, X; Zhou, J; Liu, X

    2018-02-01

    The pharmacokinetic properties and tissue distribution of enrofloxacin (EF) were investigated after single intramuscular (i.m.) dose of 10 mg/kg body weight (b.w.) in Pacific white shrimp at 22 to 25°C. EF and its metabolite ciprofloxacin (CF) were determined by high-performance liquid chromatography. After i.m. administration, EF was absorbed quickly, and the peak of EF concentration (C max ) reached at first time point in hemolymph. The volume of distribution V d(area) of EF was 3.84 L/kg, indicating that the distribution of EF was good. The area under the concentration-time curve (AUC) of EF was 90.1 and 274.2 μg hr/ml in muscle and hepatopancreas, respectively, which was higher than 75.8 μg hr/ml in hemolymph. The EF elimination was slow in muscle and hepatopancreas with the half-life (T 1/2β ) of 52.3 and 75.8 hr, respectively. CF, the mainly metabolite of EF, was detected in hemolymph, muscle and hepatopancreas. The C max was 0.030, 0.013 and 0.218 μg/ml, respectively. Based on a minimum inhibitory concentration (MIC) of 0.006-0.032 μg/ml for susceptible strains, EF i.m. injected at a dose 10 mg/kg could be efficacious against common pathogenic bacteria of Pacific white shrimp. © 2017 John Wiley & Sons Ltd.

  18. Utilizing Z-track Air Lock Technique to Reduce Pain in Intramuscular Injections

    Directory of Open Access Journals (Sweden)

    Evelyn Hemme Tambunan

    2015-04-01

    Full Text Available Introduction: Injection is one of most painful and common medical interventions that more than 12 billion of it are administered annually throughout the world. Pain remains as one of the unresolved health problems. The objective of this research was to investigate the pain severity utilizing the z-track air lock technique during intra muscular injection procedure. Method:This study was conducted as an unblinded cinical trial, where 90 female subjects aged between 18-25 years old were randomly assigned to three groups of 30. Each group received z-track air lock (Group ZTAL, air lock (AL, and z-track (Group ZT techniques. Neurobion 5000 vitamin used as an injection substance.A Verbal Rating Scale (VRS on 0–3 was used to evaluate the severity of pain during procedure. Data were analized using the SPSS version 19. Groups’ age, Body Mass Index (BMI and pain severity were analyzed through descriptive and One Way ANOVA statistics. Results: Results showed that there were no signifi cant differences of pain severity both within and between groups (p > 0.05. Discussion: Both Z-track and air lock method are less pain compared to traditional method according to previous studies. Noncicepti stimulus inhibited nocicepti stimulus in z-track technique while locking effect inhibit leakeage of substance injection to subcutaneous layer of skin which contain of nerve fi bers. However All techniques are recommended to produce less pain therefore it can be considered as a standard procedure for intra muscular injection. Keywords: intramuscular injection, z-track air lock technique, pain

  19. The effect of intramuscular administration of medroxy progesterone acetate (MPA on electrocardiographic alterations of female dogs

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    M Neshat Gharamaleky

    2010-11-01

    Full Text Available Progestins are useful for hormonal prevention of pregnancy in humans and animals. Progestrone and medroxy progestrone acetate are used for treatment of premenopausal syndrome and decreasing complications of estrogen therapy after menopause. Prescription of progesterone in dogs is usually done to control or delay estrus. If this drug is used at anestrous it will inhibit the gonadotropin excretion beyond the basic level and it will prevent cycle from happening again in proestrus or at the beginning of estrus progesterone will prevent ovulation. Use of progesterone is not totally safe in bitches. It can cause several problems such as cystic endometrial hyperplasia and pyrometera. In this study the effects of medroxy progestrone acetat (MPA on electrocardiographic changes are evaluated. After nutritional and environmental uniformity and other evaluations, the animals were divided into two groups with six bitches in each group. MPA was used at 10 mg/kg for the first group and 20 mg/kg for the second group. An ECG was recorded from the first group in time zero. MPA was injected intramuscularly and immediately after ECG recording and the time of injection was noted. Another ECG was recorded 0.5 and 2 hours after injection. The same process was repeated for the second group. It was observed that MPA at 20 mg/kg increased the heart rate and consequently PR interval and RR interval were decreased significantly in normal range. Also administration of drug at 10 mg/kg decreased the heart rate and increased PR interval, QT interval and RR interval significantly in normal range. It is probable that these observations are the result of MPAs dose dependent vasodilatory nature that induces the heart to exhibit compensative reactions such as increasing heart rate.

  20. Organização de Reparo na Conversa Cotidiana: um Estudo Empírico

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    Caroline Caputo Pires

    2017-02-01

    Full Text Available O presente trabalho visa analisar ocorrências de trajetórias de reparo com dados em fala-em-interação em uma filmagem com quatro brasileiros intercambistas na Alemanha, no qual apresentam suas experiências no período de um ano em contato com outra língua e cultural. Assim, para descrever o fenômeno de reparo (SIDNELL, 2010, GARCEZ, 2008, LODER, 2005 é importante destacar que os participantes em interação e demonstrável pela articulação de análises comunicacionais, o fenômeno do reparo é importante para a interpretação em relação à correção na fala-em-interação, na medida em que o reparo se refere às práticas que participantes usam para contornar problemas ou obstáculos na fala, audição ou compreensão da fala. Enfatiza-se, nesse trabalho, que os estudos sobre reparo na fala-em-interação se deram no campo dos estudos da Análise da Conversa, entre estudiosos que se interessam nas ações cotidianas na vida das pessoas. Dessa forma, a base empírica desse trabalho focalizará os conceitos da Análise da Conversa, fenômenos de reparo em uma filmagem de uma interação de brasileiros em intercambio no ano de 2014. Os dados empíricos fazem parte do projeto da UFMG que investiga perspectivas comunicativas e as atitudes extracomunicativas que indivíduos realizam e desenvolvem no decorrer de um encontro intercultural de duração maior.

  1. Um Processador Rápido de Corte em Momento Transverso para o Trigger da Experiência CP-LEAR

    CERN Document Server

    Machado, Emanuel Tito Mendes

    Neste trabalho pretendemos mostrar alguns aspectos importantes no desenho de instrumentação para sistemas de selecção de eventos (trigger), que se revelaram importantes no desenho do sistema de trigger de CP–LEAR. Para isso, fazemos um zoom progressivo sobre a experiência. Começamos por mostrar o que são sistemas de trigger, quais as suas propriedades e diversidade, e que tipos de sistemas são usados e em que circunstâncias. É também feito um apanhado do state of the art dos diversos componentes e soluções utilizadas para a resolução dos problemas típicos destes sistemas. A seguir, apresentamos CP–LEAR, descrevendo a física em que se apoia o seu método. Aqui introduzimos o conceito de simetrias, e em que circunstâncias podemos falar de violação de simetria. Seguidamente, introduzimos o sistema de kaões neutros, apresentamos o fenómeno de violação CP, e descrevemos o método de CP–LEAR utilizado para o seu estudo. Depois de apresentar o detector utilizado na experiência, começa...

  2. Randomised, prospective, non-blinded pilot study comparing the effect of intramuscular steroid injections and intralesional steroid injections in the management of tennis elbow

    Science.gov (United States)

    Tahir, Hasan; Biro, Izolda; Donnelly, Simon; Greenwood, Mandy

    2016-01-01

    Background Tennis elbow is an overuse injury affecting people performing repetitive forearm movements. It is a soft tissue disorder that causes significant disability and pain. The aim of the study was to establish that an intramuscular steroid injection is effective in the short-term pain relief and functional improvement of tennis elbow. The severity of pain at the injection site was monitored to determine whether the intramuscular injection is better tolerated than the intralesional injection. Methods and results 19 patients, who had no treatment for tennis elbow in the preceding 3 months, were recruited from Whipps Cross University Hospital, London, and were randomised to receive either 80 mg of intramuscular Depo-Medrone or 40 mg of intralesional Depo-Medrone injection. Blinding proved difficult as the injection sites differed and placebo arms were not included in the study. A Patient-Rated Tennis Elbow Evaluation (PRTEE) Questionnaire and a 10-point Likert scale were used to assess primary outcome. Six weeks after the treatment, there was a reduction in pain, improvement in function and total PRTEE scores in both intramuscular and intralesional groups (p=0.008) using a 95% CI for mean treatment difference of −26 to +16 points. A statistically significant result (p=0.001) in favour of intramuscular causing less pain at the injection site was noted. Conclusion Non-inferiority of intramuscular to intralesional injections was not confirmed; however, the intramuscular injection proved to be effective in reducing tennis elbow-related symptoms and was found less painful at the site of injection at the time of administration. Trial registration number EUDRACT Number: 2010-022131-11. REC Number: 10/H0718/76 (NRES, Central London REC 1). PMID:28879024

  3. Implementação paralela de um código de elementos finitos em 2D para as Equações de Navier-Stokes para fluidos incompressíveis com transporte de escalares.

    OpenAIRE

    Pedro Juan Torres López

    2010-01-01

    O estudo do fluxo de água e do transporte escalar em reservatórios hidrelétricos é importante para a determinação da qualidade da água durante as fases iniciais do enchimento e durante a vida útil do reservatório. Neste contexto, um código de elementos finitos paralelo 2D foi implementado para resolver as equações de Navier-Stokes para fluido incompressível acopladas a transporte escalar, utilizando o modelo de programação de troca de mensagens, a fim de realizar simulações em um ambiente de ...

  4. Prehospital Agitation and Sedation Trial (PhAST): A Randomized Control Trial of Intramuscular Haloperidol versus Intramuscular Midazolam for the Sedation of the Agitated or Violent Patient in the Prehospital Environment.

    Science.gov (United States)

    Isenberg, Derek L; Jacobs, Dorian

    2015-10-01

    Violent patients in the prehospital environment pose a threat to health care workers tasked with managing their medical conditions. While research has focused on methods to control the agitated patient in the emergency department (ED), there is a paucity of data looking at the optimal approach to subdue these patients safely in the prehospital setting. Hypothesis This study evaluated the efficacy of two different intramuscular medications, midazolam and haloperidol, to determine their efficacy in sedating agitated patients in the prehospital setting. This was a prospective, randomized, observational trial wherein agitated patients were administered intramuscular haloperidol or intramuscular midazolam to control agitation. Agitation was quantified by the Richmond Agitation and Sedation Scale (RASS). Paramedics recorded the RASS and vital signs every five minutes during transport and again upon arrival to the ED. The primary outcome was mean time to achieve a RASS less than +1. Secondary outcomes included mean time for patients to return to baseline mental status and adverse events. Five patients were enrolled in each study group. In the haloperidol group, the mean time to achieve a RASS score of less than +1 was 24.8 minutes (95% CI, 8-49 minutes), and the mean time for the return of a normal mental status was 84 minutes (95% CI, 0-202 minutes). Two patients required additional prehospital doses for adequate sedation. There were no adverse events recorded in the patients administered haloperidol. In the midazolam group, the mean time to achieve a RASS score of less than +1 was 13.5 minutes (95% CI, 8-19 minutes) and the mean time for the return of normal mental status was 105 minutes (95% CI, 0-178 minutes). One patient required additional sedation in the ED. There were no adverse events recorded among the patients administered midazolam. Midazolam and haloperidol administered intramuscularly appear equally effective for sedating an agitated patient in the

  5. SINERGIAS ENTRE GESTÃO DO CONHECIMENTO E PLANEJAMENTO TECNOLÓGICO: UM ESTUDO DE CASO

    Directory of Open Access Journals (Sweden)

    Hércules Antonio do Prado

    2013-08-01

    Full Text Available No âmbito das empresas da área de Tecnologia da Informação, o planejamento tecnológico é um importante instrumento de Gestão do Conhecimento que leva em conta tanto as necessidades de mercado quanto a proposição de novas soluções tecnológicas a partir do acervo tecnológico disponível ou de novos desenvolvimentos. Apesar de o planejamento tecnológico ser uma atividade intensiva no uso e na geração de conhecimento, não há reportado na literatura um pro-cesso sistemático de gestão deste conhecimento. Assim, esta pesquisa teve como objetivo escla-recer as relações entre Gestão do Conhecimento e Planejamento Tecnológico para a melhoria de processos e o aproveitamento do conhecimento gerado para a solução de problemas futuros. Co-mo instrumento de planejamento tecnológico, utilizou-se o Technology Roadmapping, técnica orientada às necessidades do negócio que auxilia na identificação, seleção e desenvolvimento das alternativas tecnológicas. Uma pesquisa quali-quantitativa foi realizada em uma organização da área de Tecnologia da Informação do Distrito Federal, em duas etapas. A primeira etapa foi uma pesquisa-ação voltada à elaboração de um Planejamento Tecnológico para subsidiar a segunda etapa, que consistiu de um levantamento de campo visando a levantar sinergias entre Gestão do Conhecimento e Planejamento Tecnológico. Os resultados encontrados desnudam pontos em que o planejamento tecnológico, por meio de um Technology Roadmapping, enriquecem o modelo de gestão do conhecimento em uma organização. Assim, novas oportunidades de negócio, funciona-lidades e produtos foram identificados a partir do compartilhamento do conhecimento utilizado na elaboração do roadmap. Ao mesmo tempo, os insumos requeridos na construção de um road-map - como pessoas com conhecimento e ambiente para realização de atividades como discussões e documentos - permitiram levantar novas demandas a serem atendidas pela

  6. Adolfo Celi, um olhar para dois mundos

    Directory of Open Access Journals (Sweden)

    Alessandra Vanucci

    2002-11-01

    Full Text Available O ensaio resgata a vivência brasileira de Adolfo Celi, ator e diretor italiano ativo em cinema e teatro (1922-1986, inserido no laboratório paulista da renovação, na década de 1950. Sua atuação impôs, no palco, o legado texto-cêntrico de Sílvio d'Amico e a utopia do ator plástico de Copeau e, na tela, a estética neo-realista associada a uma atuação fortemente marcada pelo ideário teatral moderno. As intuições, a herança, as oportunidades e as invenções perdidas desta experiência transcultural sugerem um quadro de realização somente parcial do projeto modernizador. Ao entrar na década de 60, é a sensação de ter esgotado um ciclo existencial que fornece a Celi um válido álibi para o retorno. Álibi (1969, seu terceiro e último filme como diretor, realizado na Itália com Gassmann e Lucignani, é um testemunho de vida e memórias, de raiva e de saudade do Brasil; e um precioso guia para entender sua extraordinária ‘aventura americana’.

  7. Treatment of agitation in the acute psychiatric setting. An observational study of the effectiveness of intramuscular psychotropic medication.

    Science.gov (United States)

    Bauer, Jeanett Østerby; Stenborg, Dina; Lodahl, Tue; Mønsted, Mik Mathias

    2016-11-01

    Agitation is frequent in the acute psychiatric setting. The observation and treatment of agitation is important to avoid harm to patients or staff, to reduce distress of the patient, and to reduce the risk of coercion, especially physical restraint. To evaluate the effect of intramuscular treatment with psychotropics on agitation in a non-selected acute psychiatric population. The Positive and Negative Syndrome Scale Excitement Component (PANSS-EC) was implemented in the acute psychiatric ward at Psychiatric Center Copenhagen to improve assessment and treatment of agitation. During a period of almost ~2 years the staff was requested to assess agitation before and after administration of intramuscular injections. PANSS-EC was obtained at baseline and within 2 hours after injection for 135 injections with antipsychotics or benzodiazepines administered to 101 acute, non-selected psychiatric patients with high occurrence of co-morbid substance abuse. Mean PANSS-EC at baseline was 26.53 ± 4.87, and mean reduction in PANSS-EC was 14.99 ± 8.48 (p patients were subjected to physical restraint. Patients subjected to restraint had a significantly higher PANSS-EC score. Patients who received a subsequent injection had a significantly lower decline in PANSS-EC score. Besides two cases of acute dystonia following haloperidol injections, no serious side-effects were observed. Treatment of agitation with intramuscular injections of psychotropics was in general effective in this non-selected, highly agitated psychiatric population, and injections were well tolerated.

  8. Improved neurological outcome by intramuscular injection of human amniotic fluid derived stem cells in a muscle denervation model.

    Directory of Open Access Journals (Sweden)

    Chun-Jung Chen

    Full Text Available The skeletal muscle develops various degrees of atrophy and metabolic dysfunction following nerve injury. Neurotrophic factors are essential for muscle regeneration. Human amniotic fluid derived stem cells (AFS have the potential to secrete various neurotrophic factors necessary for nerve regeneration. In the present study, we assess the outcome of neurological function by intramuscular injection of AFS in a muscle denervation and nerve anastomosis model.Seventy two Sprague-Dawley rats weighing 200-250 gm were enrolled in this study. Muscle denervation model was conducted by transverse resection of a sciatic nerve with the proximal end sutured into the gluteal muscle. The nerve anastomosis model was performed by transverse resection of the sciatic nerve followed by four stitches reconnection. These animals were allocated to three groups: control, electrical muscle stimulation, and AFS groups.NT-3 (Neurotrophin 3, BDNF (Brain derived neurotrophic factor, CNTF (Ciliary neurotrophic factor, and GDNF (Glia cell line derived neurotrophic factor were highly expressed in AFS cells and supernatant of culture medium. Intra-muscular injection of AFS exerted significant expression of several neurotrophic factors over the distal end of nerve and denervated muscle. AFS caused high expression of Bcl-2 in denervated muscle with a reciprocal decrease of Bad and Bax. AFS preserved the muscle morphology with high expression of desmin and acetylcholine receptors. Up to two months, AFS produced significant improvement in electrophysiological study and neurological functions such as SFI (sciatic nerve function index and Catwalk gait analysis. There was also significant preservation of the number of anterior horn cells and increased nerve myelination as well as muscle morphology.Intramuscular injection of AFS can protect muscle apoptosis and likely does so through the secretion of various neurotrophic factors. This protection furthermore improves the nerve

  9. Single Intramuscular-dose Toxicity of Water soluble Carthmi-Flos herbal acupuncture (WCF in Sprague-Dawley Rats

    Directory of Open Access Journals (Sweden)

    Lee Hyung-geol

    2014-03-01

    Full Text Available Objectives: This experiment was conducted to examine the toxicity of WCF (Water soluble Carthmi-Flos herbal acupuncture by administering a single intramuscular dose of WCF in 6-week-old, male and female Sprague-Dawley rats and to find the lethality dose for WCF. Methods: The experiment was conducted at Biotoxtech according to Good Laboratory Practices under a request by the Korean Pharmacopuncture Institute. This experiment was performed based on the testing standards of “Toxicity Test Standards for Drugs” by the Ministry of Food and Drug Safety. Subjects were divided into 4 groups: 1 control group in which normal saline was administered and 3 test groups in which 0.1, 0.5 or 1.0 mL of WCF was administered; a single intramuscular dose was injected into 5 males and 5 females in each group. General symptoms and body weights were observed/measured for 14 days after injection. At the end of the observation period, hematological and clinical chemistry tests were performed, followed by necropsy and histopathological examinations of the injected sections. Results: No mortalities were observed in any group. Also, symptoms, body weight, hematology, clinical chemistry and necropsy were not affected. However, histopathological examination of the injected part in one female in the 1.0-mL group showed infiltration of mononuclear cells and a multi-nucleated giant cell around eosinophilic material. Conclusion: Administration of single intramuscular doses of WCF in 3 groups of rats showed that the approximate lethal dose of WCF for all rats was in excess of 1.0 mL, as no mortalities were observed for injections up to and including 1.0 mL.

  10. Increased technetium uptake is not equivalent to muscle necrosis: scintigraphic, morphological and intramuscular pressure analyses of sore muscles after exercise

    Science.gov (United States)

    Crenshaw, A. G.; Friden, J.; Hargens, A. R.; Lang, G. H.; Thornell, L. E.

    1993-01-01

    A scintigraphic technique employing technetium pyrophosphate uptake was used to identify the area of skeletal muscle damage in the lower leg of four runners 24 h after an ultramarathon footrace (160 km). Most of the race had been run downhill which incorporated an extensive amount of eccentric work. Soreness was diffuse throughout the posterior region of the lower leg. In order to interpret what increased technetium uptake reflects and to express extreme endurance related damages, a biopsy was taken from the 3-D position of abnormal uptake. In addition, intramuscular pressures were determined in the deep posterior compartment. Scintigraphs revealed increased technetium pyrophosphate uptake in the medial portion of the gastrocnemius muscle. For 3698 fibres analysed, 33 fibres (1%) were necrotic, while a few other fibres were either atrophic or irregular shaped. A cluster of necrotic fibres occurred at the fascicular periphery for one subject and fibre type grouping occurred for another. Ultrastructural analysis revealed Z-line streaming near many capillaries and variously altered subsarcolemmal mitochondria including some with paracrystalline inclusions. The majority of the capillaries included thickened and irregular shaped endothelial cells. Intramuscular pressures of the deep posterior compartment were slightly elevated (12-15 mmHg) for three of the four subjects. Increased technetium uptake following extreme endurance running does not just reflect muscle necrosis but also subtle fibre abnormalities. Collectively, these pathological findings are attributed to relative ischaemia occurring during the race and during pre-race training, whereas, intramuscular pressure elevations associated with muscle soreness are attributed to mechanical stress caused by extensive eccentric work during the race.

  11. Fatty rind of intramuscular soft-tissue tumors of the extremity: is it different from the split fat sign?

    Energy Technology Data Exchange (ETDEWEB)

    Sung, Jinkyeong; Kim, Jee-Young [The Catholic University of Korea, Departments of Radiology, St. Vincent' s Hospital, College of Medicine, Suwon, Gyeonggi-do (Korea, Republic of)

    2017-05-15

    To analyze intramuscular soft-tissue tumors with fatty rind, and to evaluate the difference between fatty rind and split fat sign on magnetic resonance imaging (MRI). We retrospectively analyzed 50 pathologically confirmed intramuscular masses on MRI. We evaluated the distribution and shape of fatty rind and muscle atrophy. Fatty rind was found more frequently in benign lesions (80% [36 out of 45]) compared with malignant lesions (25% [1 out of 5]; P = 0.013). Thirty-six benign lesions were peripheral nerve sheath tumors (PNSTs; n = 19), hemangiomas (n = 11), myxomas (n = 2), ganglion cysts (n = 2), giant cell tumor (n = 1), and leiomyoma (n = 1). One malignant lesion was a low-grade fibromyxoid sarcoma. In all masses with fatty rind, fat was confined to the proximal and the distal ends. In 12 cases, complete or partial circumferential fatty rind was also noted. Fatty rinds at both ends showed crescent, triangular, or combined shape. The prevalence of crescent-shaped fatty rind was significantly higher in benign PNST (17 out of 38) compared with the other tumors (1 out of 32; P < 0.001). Complete circumferential fat was noted only in hemangioma (n = 5). Triangular fatty rind was related to peripheral location of the mass or muscle atrophy. Most intramuscular tumors with fatty rinds were benign, and PNST was the most common tumor type. Fatty rind could be caused by displaced neurovascular bundle fat, fatty atrophy of the muscle involved, or intermuscular or perimysial fat. Crescent-shaped fatty rind was noted more frequently in benign PNSTs. (orig.)

  12. Fatty rind of intramuscular soft-tissue tumors of the extremity: is it different from the split fat sign?

    International Nuclear Information System (INIS)

    Sung, Jinkyeong; Kim, Jee-Young

    2017-01-01

    To analyze intramuscular soft-tissue tumors with fatty rind, and to evaluate the difference between fatty rind and split fat sign on magnetic resonance imaging (MRI). We retrospectively analyzed 50 pathologically confirmed intramuscular masses on MRI. We evaluated the distribution and shape of fatty rind and muscle atrophy. Fatty rind was found more frequently in benign lesions (80% [36 out of 45]) compared with malignant lesions (25% [1 out of 5]; P = 0.013). Thirty-six benign lesions were peripheral nerve sheath tumors (PNSTs; n = 19), hemangiomas (n = 11), myxomas (n = 2), ganglion cysts (n = 2), giant cell tumor (n = 1), and leiomyoma (n = 1). One malignant lesion was a low-grade fibromyxoid sarcoma. In all masses with fatty rind, fat was confined to the proximal and the distal ends. In 12 cases, complete or partial circumferential fatty rind was also noted. Fatty rinds at both ends showed crescent, triangular, or combined shape. The prevalence of crescent-shaped fatty rind was significantly higher in benign PNST (17 out of 38) compared with the other tumors (1 out of 32; P < 0.001). Complete circumferential fat was noted only in hemangioma (n = 5). Triangular fatty rind was related to peripheral location of the mass or muscle atrophy. Most intramuscular tumors with fatty rinds were benign, and PNST was the most common tumor type. Fatty rind could be caused by displaced neurovascular bundle fat, fatty atrophy of the muscle involved, or intermuscular or perimysial fat. Crescent-shaped fatty rind was noted more frequently in benign PNSTs. (orig.)

  13. Effect of different adjuvant formulations on the immunogenicity and protective effect of a live Mycoplasma hyopneumoniae vaccine after intramuscular inoculation.

    Science.gov (United States)

    Xiong, Qiyan; Wei, Yanna; Xie, Haidong; Feng, Zhixin; Gan, Yuan; Wang, Chunlai; Liu, Maojun; Bai, Fangfang; Xie, Fang; Shao, Guoqing

    2014-06-05

    Mycoplasma hyopneumoniae (M. hyopneumoniae) vaccine strain 168 is an intrapulmonically injected attenuated live vaccine that is available in the Chinese market. The aim of this study was to develop suitable adjuvants for this live vaccine to provide effective protection after intramuscular inoculation. Several adjuvant components were screened to assess their toxicity for the live vaccine, and various adjuvant formulations were then designed and prepared. Vaccines supplemented with these adjuvants were used to immunize mice intramuscularly to assess the capacity of the adjuvants to induce a specific immune response. The screened formulations were then evaluated in pigs. Seven of the eight adjuvant components did not affect the viability of the live vaccine, and seven different adjuvant formulations were then designed. In mice, the ISCOM-matrix adjuvant and the levamisole-chitosan mixture adjuvant significantly enhanced serum IgG responses against M. hyopneumoniae, while lymphocyte proliferation was enhanced by the ISCOM-matrix adjuvant, the carbomer-astragalus polysaccharide mixture adjuvant and an oil-in-water emulsion adjuvant. These four adjuvants were evaluated in pigs. Enhancement of specific lymphocyte proliferation responses was observed in the groups vaccinated with the ISCOM-matrix adjuvant and the carbomer-astragalus polysaccharide mixture adjuvant. Significant enhancement of serum IgG antibody production was observed before challenge in pigs vaccinated with the carbomer-astragalus polysaccharide mixture adjuvant and the levamisole-chitosan mixture adjuvant, while after challenge, all of the animals that received vaccines containing adjuvants had higher antibody concentrations against M. hyopneumoniae than unvaccinated animals. Animals inoculated with a vaccine containing the ISCOM-matrix adjuvant (median score 3.57) or the carbomer-astragalus polysaccharide mixture adjuvant (median score 5.28) had reduced lesion scores compared to unvaccinated animals

  14. Rats and rabbits as pharmacokinetic screening tools for long acting intramuscular depots: case study with paliperidone palmitate suspension.

    Science.gov (United States)

    Patel, Harilal; Patel, Prakash; Modi, Nirav; Patel, Pinakin; Wagh, Yogesh; George, Alex; Desai, Nirmal; Srinivas, Nuggehally R

    2018-05-08

    Development of prodrug of 9-hydroxyrisperidone (paliperidone) long-acting intramuscular injection has enabled delivery over four-week time period with improved compliance. The key aim of this work was to establish a reliable preclinical model which may potentially serve as a screening tool for judging the pharmacokinetics of paliperidone formulation(s) prior to human clinical work. Sparse sampling composite study was used in rats, (Wistar/Sprague-Dawley (SD; n = 10)) and a serial blood sampling study design was used in rabbits (n = 4). Animals received intramuscular injection of paliperidone palmitate in the thigh muscle at dose of 16 (rats) and 4.5 mg/kg (rabbits). Samples were drawn in rats (retro-orbital sinus) and rabbits (central ear artery) and were analysed for paliperidone using liquid chromatography-mass spectrometry/ mass spectrometry (LC-MS/MS) assay. The plasma data was subjected to pharmacokinetic analysis. Following intramuscular injection of depot formulation in Wistar/SD rats and rabbits, absorption of paliperidone was slow and gradual with median value of time to reach maximum concentration (T max ) occurring on day 7. The exposures (i.e. area under the curve (AUC; 0-28) days) were 18,597, 21,865 and 18,120 ng.h/mL, in Wistar, SD and rabbits, respectively. The clearance was slow and supported long half-life (8-10 days). Either one of the two models can serve as a research tool for establishing pharmacokinetics of paliperidone formulation(s).

  15. Clinical effects of dexmedetomidine combined with methadone after intranasal and intramuscular administration in dogs

    Directory of Open Access Journals (Sweden)

    Daniela Gioeni

    2018-06-01

    Full Text Available The intranasal (IN route shows promise for chemical restraint given the large area offered for drugs absorption. The nasal turbinates increase nasal mucosa surface, which have a greater blood flow than muscle, brain and liver tissue . Aim of the study is to compare the clinical effects and sedation scores following either IN or intramuscular (IM administration of dexmedetomidine-methadone in dogs. Twenty mixed-breed, client-owned, healthy dogs, undergoing soft tissue surgery or diagnostic procedures, were randomly allocated in two groups (n = 10 to receive dexmedetomidine (0.01 mg kg-1 together with methadone (0.4 mg kg-1 IN (IN-group or IM (IM-group. Temperament was evaluated before premedication (1 = calm and friendly, 4 = very excitable or nervous (Maddern et al. 2010. Heart rate (HR, respiratory frequency (fR, body temperature, and side effects were recorded before (T0 and 10 (T10, 20 (T20 and 30 (T30 minutes after premedication. Sedation was scored 3 times (every 10 minutes after drugs administration using a descriptive sedation scale (0 = no sedation, 13 = extremely sedated. Induction was performed at T30 with titrate-to-effect propofol and the dosage was recorded. Student T-test was performed. Weight, age, temperament, body temperature and propofol dose were not different between groups. At each time point, excluding T0, IM-group showed a statistically lower HR and fRcompared to IN-group. No undesirable effects were observed in both groups. Sedation score in IM-group was significantlyhigher compared to IN-group at each time point. In conclusion, despite statistical differences, IN administration produces a satisfactory clinical sedation with more gradual hemodynamic effects compared to IM injection; this is probably due to a direct transport of drugs from cranial nerves (I-V to brain with limited systemic absorption. However, the high variability recorded in sedation score between subjects in IN-group (min 1/13; max 13/13 at T30

  16. Pharmacokinetics of dexmedetomidine combined with methadone following oral-transmucosal and intramuscular administration in dogs

    Directory of Open Access Journals (Sweden)

    Federica Di Cesare

    2017-05-01

    Full Text Available Oral-transmucosal (OTM drug delivery refers to noninvasive and painless administration of medical preparations through any oral cavity membrane to achieve systemic effects (Sattar et al., 2014. Regarding sedative drugs, OTM administration is very attractive in veterinary medicine, especially for patients difficult to inject and restrain (Messenger et al., 2016. This study aims to compare the pharmacokinetics of dexmedetomidine after OTM and intramuscular (IM administration combined with methadone. After obtaining Ethical Committee approval and owner’s written consent, eight dogs, were administered with dexmedetomidine (10 mg/kg and methadone (0.4 mg/kg by OTM and other 4 dogs by IM route. Blood samples were collected at prefixed times up to four hours. Dexmedetomidine was quantified by a validated HPLC-MS method. On dexmedetomidine concentrations, a pharmacokinetic analysis was carried out with a noncompartmental approach (Phoenix WinNonlin® 7.0, Pharsight, Cary, NC. Mean ± SD terminal half-lives of dexmedetomidine were 187.42 ± 109.66 and 94.78 ± 34.08 min after OTM and IM administration, respectively. Maximum serum (Cmax concentrations were 0.83 ± 0.32 and 9.09 ± 2.46 ng/mL for OTM and IM administration, respectively. Time to maximum concentration (Tmax were 44.38 ± 32.16 and 21.25±11.39 min by OTM and IM administration, respectively. Area under the curve from 0 to the last measured concentration (AUClast were 103.75 ± 30.23 and 614.87 ± 77.15 min*ng/mL for OTM and IM administration, respectively. Cmax, Tmax and AUClast values by OTM route demonstrate a lower and delayed absorption of the drug compared to IM. To complete the study, the pharmacokinetic analysis of methadone is foreseen, so as a clinical trial to compare the clinical effects of the combination of dexmedetomidine and methadone by OTM and IM administration and to establish an effective dosage of oral-transumucosal route in dogs for this association.

  17. Sustained-release progesterone nanosuspension following intramuscular injection in ovariectomized rats

    Directory of Open Access Journals (Sweden)

    Heba F Salem

    2010-11-01

    Full Text Available Heba F SalemFaculty of Pharmacy, Beni-Suef University, Beni-Suef, EgyptAbstract: The production of an intramuscular (IM injection of natural progesterone would provide a safer solution than using semi synthetic progesterone. However, disadvantages such as low solubility and a short half life prevent the use of natural progesterone. In this study, we formulated a sustained release form of natural progesterone to be given as IM injection. A progesterone nanosuspension (PNS was first developed and then dispersed in a thermosensitive gel matrix. The selected nanoparticles showed an average particle size of 267 nm and a zeta potential approaching-41 mV. The in vitro release profile of PNS from the F127 plus methyl cellulose gel followed zero order kinetics and correlated linearly with the weight percentage of gel dissolved, demonstrating that the overall rate of release of PNS is controlled by dissolution of the pluronic F127/methyl cellulose (MC gel (r2 > 0.99. The pharmacokinetic parameters of the PNS (6 mg/mL in pluronic F127/MC gel were evaluated in comparison with the control progesterone suspension. After the administration of PNS in F127/MC gel into the rats, a maximum serum concentration of 22.1 ± 1.9 ng/mL was reached at a Tmax of 4.05 ± 0.1 h. The terminal half life was 12.7 ± 0.8 h. The area under the curve AUC0-∞ of the injected formula was 452.75 ± 42.8 ng•h/mL and the total mean residence time was 18.57 ± 1.44 h. The PNS in gel was significantly different from the control in rate and extent at P < 0.001. The natural progesterone which was nanosized and formulated in a thermosensitive gel significantly sustained the action of natural progesterone so that it could be injected every 36 h instead of every day. Moreover, this formula is expected to provide a much safer choice than the use of semi-synthetic progesterone.Keywords: progesterone, nanosuspension, thermosensitive gel, ovariectomized female rats

  18. Sustained-release progesterone nanosuspension following intramuscular injection in ovariectomized rats.

    Science.gov (United States)

    Salem, Heba F

    2010-11-10

    The production of an intramuscular (IM) injection of natural progesterone would provide a safer solution than using semi synthetic progesterone. However, disadvantages such as low solubility and a short half life prevent the use of natural progesterone. In this study, we formulated a sustained release form of natural progesterone to be given as IM injection. A progesterone nanosuspension (PNS) was first developed and then dispersed in a thermosensitive gel matrix. The selected nanoparticles showed an average particle size of 267 nm and a zeta potential approaching-41 mV. The in vitro release profile of PNS from the F127 plus methyl cellulose gel followed zero order kinetics and correlated linearly with the weight percentage of gel dissolved, demonstrating that the overall rate of release of PNS is controlled by dissolution of the pluronic F127/methyl cellulose (MC) gel (r² > 0.99). The pharmacokinetic parameters of the PNS (6 mg/mL) in pluronic F127/MC gel were evaluated in comparison with the control progesterone suspension. After the administration of PNS in F127/MC gel into the rats, a maximum serum concentration of 22.1 ± 1.9 ng/mL was reached at a T(max) of 4.05 ± 0.1 h. The terminal half life was 12.7 ± 0.8 h. The area under the curve AUC₀₋∞ of the injected formula was 452.75 ± 42.8 ng·h/mL and the total mean residence time was 18.57 ± 1.44 h. The PNS in gel was significantly different from the control in rate and extent at P < 0.001. The natural progesterone which was nanosized and formulated in a thermosensitive gel significantly sustained the action of natural progesterone so that it could be injected every 36 h instead of every day. Moreover, this formula is expected to provide a much safer choice than the use of semi-synthetic progesterone.

  19. Expression profiles and associations of adiponectin and adiponectin receptors with intramuscular fat in Tibetan chicken.

    Science.gov (United States)

    Zhang, R; Lin, Y; Zhi, L; Liao, H; Zuo, L; Li, Z; Xu, Y

    2017-04-01

    1. Adiponectin and its receptors (ADIPOR1 and ADIPOR2) are novel endocrine systems that act at various levels to modulate glucose and lipid metabolism. This study was designed to investigate the spatial expression of adiponectin, ADIPOR1 and ADIPOR2 genes in various tissues in Tibetan chicken. The temporal expression of adiponectin and its receptor mRNAs were also studied in adipose tissue, breast muscle and thigh muscle and the correlations of the levels of adiponectin, ADIPOR1 and ADIPOR2 mRNA with the contents of intramuscular fat in breast muscle and thigh muscle of Tibetan chicken were determined. 2. Quantitative real-time PCR detected chicken adiponectin, ADIPOR1 and ADIPOR2 mRNA transcripts in heart, liver, spleen, lung, kidney, skeletal muscle and adipose tissue. 3. Adipose tissue contained the highest amount of adiponectin mRNA followed by the kidney and liver. The expression levels of ADIPOR1 mRNA were significantly higher in adipose tissue, lung and spleen, and adipose tissue exhibited significantly higher levels of ADIPOR2 mRNA followed by the spleen and lung compared with other tissues. 4. Temporal expression profiles of adiponectin, ADIPOR1 and ADIPOR2 mRNA showed gender differences in adipose tissue and skeletal muscle at certain ages. In adipose tissue, adiponectin mRNA was higher in 154-d-old females and ADIPOR1 mRNA was higher in 154-d-old males: Adiponectin and ADIPOR2 mRNA were higher, and ADIPOR1 mRNA was lower, in thigh muscle in female compared with male chickens. 5. The correlation data showed that, except for adiponectin mRNA, the levels of ADIPOR1 and ADIPOR2 mRNA in thigh muscle of males were significantly positively correlated with IMF (r = 0.206 for the ADIPOR1 gene and r = 0.676 for the ADIPOR2 gene). 6. Taken together, it was concluded that adiponectin and the ADIPOR1 and ADIPOR2 genes are ubiquitously expressed in various tissues of Tibetan chicken and the expression of the adiponectin system is gender-dependant at certain ages

  20. Comparative pharmacokinetics of cefuroxime lysine after single intravenous, intraperitoneal, and intramuscular administration to rats.

    Science.gov (United States)

    Zhao, Long-shan; Yin, Ran; Wei, Bin-bin; Li, Qing; Jiang, Zhen-yuan; Chen, Xiao-hui; Bi, Kai-shun

    2012-11-01

    To compare the pharmacokinetic parameters of cefuroxime lysine, a new second-generation of cephalosporin antibiotics, after intravenous (IV), intraperitoneal (IP), or intramuscular (IM) administration. Twelve male and 12 virgin female Sprague-Dawley rats, weighing from 200 to 250 g, were divided into three groups (n=4 for each gender in each group). The rats were administered a single dose (67.5 mg/kg) of cefuroxime lysine via IV bolus or IP or IM injection. Blood samples were collected and analyzed with a validated UFLC-MS/MS method. The concentration-time data were then calculated by compartmental and non-compartmental pharmacokinetic methods using DAS software. After IV, IP or IM administration, the plasma cefuroxime lysine disposition was best described by a tri-compartmental, bi-compartmental or mono-compartmental open model, respectively, with first-order elimination. The plasma concentration profiles were similar through the 3 administration routes. The distribution process was rapid after IV administration [t(1/2(d)), 0.10 ± 0.11 h vs 1.36 ± 0.65 and 1.25 ± 1.01 h]. The AUMC(0-∞) is markedly larger, and mean residence time (MRT) is greatly longer after IP administration than that in IV, or IM routes (AUMC(0-∞): 55.33 ± 20.34 vs 16.84 ± 4.85 and 36.17 ± 13.24 mg·h(2)/L; MRT: 0.93 ± 0.10 h vs 0.37 ± 0.07 h and 0.65 ± 0.05 h). The C(max) after IM injection was significantly higher than that in IP injection (73.51 ± 12.46 vs 49.09 ± 7.06 mg/L). The AUC(0-∞) in male rats were significantly higher than that in female rats after IM administration (66.38 ± 16.5 vs 44.23 ± 6.37 mg·h/L). There was no significantly sex-related difference in other pharmacokinetic parameters of cefuroxime lysine between male and female rats. Cefuroxime lysine shows quick absorption after IV injection, a long retension after IP injection, and a high C(max) after IM injection. After IM administration the AUC(0-∞) in male rats was significantly larger than that in

  1. Pharmacokinetics of butorphanol after intravenous, intramuscular, and oral administration in Hispaniolan Amazon parrots (Amazona ventralis).

    Science.gov (United States)

    Guzman, David Sanchez-Migallon; Flammer, Keven; Paul-Murphy, Joanne R; Barker, Steven A; Tully, Thomas N

    2011-09-01

    Previous studies have validated the clinical use of opioids with kaap-receptor affinities for pain management in birds. Butorphanol, a kappa opioid receptor agonist and a mu opioid receptor antagonist, is currently considered by many clinicians to be the opioid of choice for this use. However, despite studies reporting the analgesic properties of butorphanol in psittacine birds, dosing intervals have not been established for any psittacine species. The goals of this study in the Hispaniolan Amazon parrot (Amazona ventralis) were to evaluate the pharmacokinetics of butorphanol tartrate after intravenous (IV), intramuscular (IM), and oral (PO) administration and to determine the bioavailability of butorphanol tartrate after oral administration. Twelve Hispaniolan Amazon parrots were used in the study, with a complete-crossover experimental design and a 3-month period separating each part of the study. The birds were randomly assigned to 3 groups (n = 4) for each stage. Butorphanol tartrate was administered once at a dose of 5 mg/kg in the basilic vein or pectoral muscles or as an oral solution delivered via feeding tube into the crop for the IV, IM, and PO studies, respectively. After butorphanol administration, blood samples were collected at 1, 5, 15, 30, 60, 90, 120, 180, and 240 minutes for the IV and IM studies and at 5, 15, 30, 60, 90, 120, 180, 240, and 300 minutes for the PO study. Because of the size limitation of the birds, naive pooling of datum points was used to generate a mean plasma butorphanol concentration at each time point. For each study, birds in each group (n = 4) were bled 3 times after dosing. Plasma butorphanol concentrations were determined by high-performance liquid chromatography/tandem mass spectrometry, and pharmacokinetic parameters were calculated. Butorphanol tartrate was found to have high bioavailability and rapid elimination following IM administration. In contrast, oral administration resulted in low bioavailability (Amazon

  2. Central Role of the PPARγ Gene Network in Coordinating Beef Cattle Intramuscular Adipogenesis in Response to Weaning Age and Nutrition

    OpenAIRE

    Moisá, Sonia J.; Shike, Daniel W.; Faulkner, Dan B.; Meteer, William T.; Keisler, Duane; Loor, Juan J.

    2014-01-01

    Adipogenic/lipogenic transcriptional networks regulating intramuscular fat deposition (IMF) in response to weaning age and dietary starch level were studied. The longissimus muscle (LM) of beef steers on an early weaning (141 days age) plus high-starch diet (EWS) or a normal weaning (NW, 222 days age) plus starch creep-feed diet (CFS) was biopsied at 0 (EW), 25, 50, 96 (NW), 167, and 222 (pre-slaughter) days. Expression patterns of 35 target genes were studied. From NW through slaughter, all ...

  3. Topical Administration Is a Promising Inoculating Route versus Intramuscular Inoculation for the Nanoparticle-Carried DNA Vaccine to Prevent Corneal Infections.

    Science.gov (United States)

    Hu, Kai; Malla, Tejsu; Zhai, Yujia; Dong, Lili; Tang, Ru

    2015-01-01

    To evaluate the comparative effect of topical versus intramuscular administration of nanoparticle-carried DNA vaccine in preventing corneal herpes simplex virus type 1 (HSV-1) infection. Nanoparticle [polyethylenimine (PEI)-Fe3O4]-carried DNA vaccine (PEI-Fe3O4-pRSC-gD-IL-21) or DNA vaccine (pRSC-gD-IL-21) alone were topically versus intramuscularly inoculated into one eye each of mice on days 0, 14 and 28. Three weeks after the final immunization, the specific immune responses and clinical degrees of primary herpes simplex keratitis were evaluated. Topical inoculation of nanoparticle-carried DNA vaccine induced mice to generate similar levels of specific HSV-1-neutralizing antibody, IFN-γ and IL-4 in serum and specific killing (cytotoxicity) and proliferative activities of the splenic lymphocytes, but a significantly higher level of secretory IgA in tears compared to those of intramuscular inoculation. More importantly, the mice inoculated topically showed a significantly decreased herpes simplex keratitis severity than the mice inoculated intramuscularly after HSV-1 challenge on the corneas of the mice. Topical inoculation of nanoparticle-carried DNA vaccine elicits a stronger specific local immune response and more effectively inhibits herpes simplex keratitis as compared to intramuscular inoculation in an HSV-1 ocular challenge mouse model. Thus, topical administration may be a promising inoculating route for the nanoparticle-carried DNA vaccine to prevent corneal infections. © 2015 S. Karger AG, Basel.

  4. Lipoma vulvar: um relato de caso

    Directory of Open Access Journals (Sweden)

    Mariano Lopes da Silva Filho

    2012-04-01

    Full Text Available Os lipomas são os tumores benignos mais comuns dos tecidos moles. No entanto, lipomas localizados em vulva são extremamente raros e a literatura é incerta quanto à sua incidência mundial. O objetivo deste artigo é descrever um caso clínico de lipoma localizado em vulva em uma mulher de 35 anos. A paciente queixava-se de massa de crescimento insidioso localizada no grande lábio inferior. O ultrassom de partes moles evidenciou um nódulo subcutâneo da linhagem lipomatosa. Foi realizada a exérese do lipoma, e a análise histopatológica confirmou que se tratava de um lipoma.

  5. Modulação do eixo corticotrófico na caquexia neoplásica em um modelo animal

    OpenAIRE

    Jefferson Crespigio

    2013-01-01

    A síndrome da anorexia-caquexia (SAC) é uma importante condição clínica no câncer em estágio avançado, estando relacionada à importante diminuição de sobrevida nos pacientes. A presença do tumor e sua interação com o hospedeiro desencadeiam a liberação de várias substâncias como interleucinas, caracterizando um estado de estresse, com consequente ativação do eixo hipotálamo-hipófise-adrenal (HPA). O objetivo do presente trabalho foi avaliar a influência da caquexia neoplásica sobre o eixo HPA...

  6. Um panorama da literatura relevante sobre Itaipu

    OpenAIRE

    Espósito Neto, Tomaz

    2013-01-01

    A hidroelétrica brasileiro-paraguaia de Itaipu é considerada um marco relevante nas relações entre Brasil e Paraguai, pois criou um vínculo permanente entre os dois países. Ainda nos dias atuais Itaipu é uma das maiores geradoras de energia do mundo, responsável por mais de 25 por cento da energia gerada no Brasil e cerca de 95 por cento da eletricidade consumida no Paraguai. Os diversos reflexos da construção de Itaipu, em especial as mudanças na estrutura de poder no Cone Sul, são fenômenos...

  7. A obesidade infantil: um problema emergente

    OpenAIRE

    Sousa, Joana; Loureiro, Isabel; Carmo, Isabel do

    2008-01-01

    A obesidade é um dos problemas de saúde mais graves que afecta crianças e adolescentes a nível mundial. As evidências sugerem que o problema está a agravar-se rapidamente. O aumento da prevalência de obesidade infantil pode fazer com que a próxima geração apresente indicadores de obesidade no adulto superiores aos indicadores actuais. Pelo facto de a obesidade estar intimamente associada a diferentes patologias crónicas faz com que estejamos perante um enorme desafio para o sistema de cuidado...

  8. Doença de Kikuchi-Fujimoto: apresentação de um caso

    Directory of Open Access Journals (Sweden)

    Jailson de Sousa Oliveira

    2017-08-01

    Full Text Available A doença de Kikuchi-Fujimoto (DKF ou linfadenite histiocítica necrotizante é uma doença benigna e auto-limitada, rara, caracterizada por linfadenopatia generalizada, febre e leucopenia. É um importante diagnóstico diferencial com patologias linfoproliferativas, autoimunes, infecciosas, podendo em raros casos estar associada a estas. Relatamos o caso de um paciente de 24 anos, com quadro de febre, linfadenopatia cervical e inguinal e lesões cutaneomucosas. O Fator Anti-Nuclear (FAN foi positivo, hemograma evidenciou pancitopenia, anti-DNA negativo. A biópsia de linfonodo inguinal evidenciou linfadenite histiocítica necrotizante. O paciente evoluiu com piora clínica por atividade de doença associada a sepse, evoluindo com pericardite aguda e tamponamento cardíaco. Realizado pulsoterapia com ciclofosfamida, com melhora substancial das manifestações cutâneas e sistêmicas. O diagnóstico de pacientes com DKF deve implicar necessariamente no seguimento para avaliação do surgimento de doenças autoimunes, assim como doenças infecciosas e linfoproliferativas.

  9. Pedro Ferreira, um escultor baiano desconhecido Pedro Ferreira, an unknown sculptor from Bahia

    Directory of Open Access Journals (Sweden)

    Maria Helena Ochi Flexor

    2008-12-01

    Full Text Available Este trabalho é o resultado do início de um estudo sobre o escultor Pedro Ferreira. Embora seja autor de obras importantes, passa quase desapercebido na historiografia da arte baiana. Trata-se de artista que pertence ao tempo em que o neoclassicismo se impunha à cultura Ocidental, porém, ainda restavam, na Bahia, as práticas do período barroco, em especial a cópia dos grandes mestres renascentistas. Pedro Ferreira foi um desses artistas e teve como principal inspirador Murillo, da escola espanhola.This work is the result of a beginning study about a sculptor Pedro Ferreira. Although he was author of important workmanships, he passes almost unknown in the bahian history of art. He was an artist who lives belongs a time when the neoclassicismo was imposed to the Occidental culture, but, still remained in Bahia, the practical ones of the baroque period, in special the copy of the great Renaissance masters. Pedro Ferreira was one of these artists and has inspired, as main artist, Murillo, of the Spanish school.

  10. Relato de um caso de melanoma de conjuntiva Conjuntival melanoma: a case report

    Directory of Open Access Journals (Sweden)

    Carlos Gustavo Leite Vieira

    2000-10-01

    Full Text Available Objetivo: Relatar um caso raro de melanoma de conjuntiva de longa evolução em paciente melanodérmica. Método: Análise de caso. Resultado: Até a presente data a paciente encontra-se bem sem evidências de recorrência da patologia em questão após excisão local. Conclusão: Observamos que mesmo sem a realização de crioterapia adjuvante ou medidas mais agressivas, existem alguns casos como esse que acabamos de relatar para o qual a excisão simples pode garantir a cura. Um aspecto importante deste relato é a importância do exame histopatológico de peças e fragmentos cirúrgicos removidos.Purpose: The authors describe a rare case of malignant conjunctival melanoma with a long evolution. Methods: A case report. Results: Until this time the patient does not show any sign of relapse of this melanoma, after local excision. Conclusion: Without cryotherapy or more agressive methods we observe that there are some cases of conjunctival melanoma that might be cured with only a local excision. An important aspect of this case is the relevance of the histopathologic analysis of the removed surgical fragments.

  11. Plantilla 1: El documento audiovisual: elementos importantes

    OpenAIRE

    Alemany, Dolores

    2011-01-01

    Concepto de documento audiovisual y de documentación audiovisual, profundizando en la distinción de documentación de imagen en movimiento con posible incorporación de sonido frente al concepto de documentación audiovisual según plantea Jorge Caldera. Diferenciación entre documentos audiovisuales, obras audiovisuales y patrimonio audiovisual según Félix del Valle.

  12. Valores Associados à Compra de Automóvel por Jovens no Ceará: Um Estudo sob a Ótica da Cadeia de Meios-Fim

    Directory of Open Access Journals (Sweden)

    Natália de Sena Nunes

    2012-12-01

    Full Text Available O setor automotivo enfrenta um ambiente competitivo e, por isso, precisa implementar estratégias de diferenciação para que o consumidor prefira uma empresa em detrimento a outra. A fim de alcançar atingir o seu objetivo, as organizações devem criar estratégias que podem ser traçadas através da conquista de um público específico, o jovem. Para conquistar esse público, porém, deve-se buscar entender o que os motiva a adquirir um veículo, quais são os valores por trás da compra de um determinado automóvel, para que a empresa possa oferecer realmente um carro que o cliente procura. Esse, portanto, é o objetivo desta pesquisa, que é analisada sob a ótica da teoria de meios-fim, tão importante para a identificação de atributos, consequências e valores envolvidos na relação do jovem e o automóvel. DOI: 10.5585/remark.v11i3.2298

  13. Intramuscular adrenaline does not reduce the incidence of respiratory distress and hypoglycaemia in neonates delivered by elective caesarean section at term

    DEFF Research Database (Denmark)

    Pedersen, Pernille; Avlund, O L; Pedersen, B L

    2008-01-01

    AIM: To test whether intramuscular injection of 30 microg adrenaline decreased the incidence of respiratory distress and hypoglycaemia in term infants delivered by elective caesarean section before active labour. METHOD: The study was randomised and double-blinded. A total of 270 neonates were...... assigned to intramuscular treatment with saline (0.30 ml) or 30 microg adrenaline (0.30 ml) immediately after birth. The primary endpoint was referral to the neonatal ward because of respiratory distress or a blood glucose level ... with pulse oximetry to disclose potential side effects. RESULTS: Pulse-oximetry recordings revealed a modest systemic effect by intramuscular adrenaline as the heart rate and the haemoglobin oxygen saturation were significantly higher in infants who received adrenaline. In contrast, the incidence...

  14. PHARMACOKINETICS OF CEFTIOFUR CRYSTALLINE FREE ACID STERILE SUSPENSION IN GREEN IGUANAS ( IGUANA IGUANA) AFTER SINGLE INTRAMUSCULAR ADMINISTRATION.

    Science.gov (United States)

    Sadar, Miranda J; Hawkins, Michelle G; Taylor, Ian T; Byrne, Barbara A; Tell, Lisa A

    2018-03-01

    The objective of this study was to establish the pharmacokinetic parameters of ceftiofur crystalline free acid (CCFA) for a single intramuscular injection in green iguanas ( Iguana iguana). Six green iguanas received an injection of 5 mg/kg CCFA into the triceps muscle. Using high-performance liquid chromatography, concentrations of ceftiofur free acid equivalents in plasma samples collected at predetermined time points were evaluated up to 21 days following drug administration. Noncompartmental pharmacokinetic analysis was applied to the data. The observed maximum plasma concentration (C max obs ) was 2.765 ± 0.864 μg/mL, and the time of observed maximum concentration (T max obs ) was 6.1 ± 9.2 hr. The area under the curve (0 to infinity) was 239.3 ± 121.1 μg·hr/mL. No significant adverse drug reactions were clinically observed, and no visible injection site reactions were noted. Minimum inhibitory concentrations of bacterial isolates from iguanas were used to establish a target plasma concentration of 2.0 μg/mL. Based on the results from this study, a potential dosing interval for ceftiofur crystalline free acid administered at 5 mg/kg intramuscularly for iguanas maintained at a temperature of 30°C would be 24 hr based on a target plasma concentration of 2 μg/mL; however, multidose studies still need to be performed.

  15. Survey of Botulinum Toxin Injections in Anticoagulated Patients: Korean Physiatrists' Preference in Controlling Anticoagulation Profile Prior to Intramuscular Injection.

    Science.gov (United States)

    Jang, Yongjun; Park, Geun-Young; Park, Jihye; Choi, Asayeon; Kim, Soo Yeon; Boulias, Chris; Phadke, Chetan P; Ismail, Farooq; Im, Sun

    2016-04-01

    To evaluate Korean physiatrists' practice of performing intramuscular botulinum toxin injection in anticoagulated patients and to assess their preference in controlling the bleeding risk before injection. As part of an international collaboration survey study, a questionnaire survey was administered to 100 Korean physiatrists. Physiatrists were asked about their level of experience with botulinum toxin injection, the safe international normalized ratio range in anticoagulated patients undergoing injection, their tendency for injecting into deep muscles, and their experience of bleeding complications. International normalized ratio injection by 41% of the respondents. Thirty-six respondents replied that the international normalized ratio should be lowered to sub-therapeutic levels before injection, and 18% of the respondents reported that anticoagulants should be intentionally withheld and discontinued prior to injection. In addition, 20%-30% of the respondents answered that they were uncertain whether they should perform the injection regardless of the international normalized ratio values. About 69% of the respondents replied that they did have any standardized protocols for performing botulinum toxin injection in patients using anticoagulants. Only 1 physiatrist replied that he had encountered a case of compartment syndrome. In accordance with the lack of consensus in performing intramuscular botulinum toxin injection in anticoagulated patients, our survey shows a wide range of practices among many Korean physiatrists; they tend to avoid botulinum toxin injection in anticoagulated patients and are uncertain about how to approach these patients. The results of this study emphasize the need for formulating a proper international consensus on botulinum toxin injection management in anticoagulated patients.

  16. Effect of exposure routes on the relationships of lethal toxicity to rats from oral, intravenous, intraperitoneal and intramuscular routes.

    Science.gov (United States)

    Ning, Zhong H; Long, Shuang; Zhou, Yuan Y; Peng, Zi Y; Sun, Yi N; Chen, Si W; Su, Li M; Zhao, Yuan H

    2015-11-01

    The lethal toxicity values (log 1/LD(50)) of 527 aliphatic and aromatic compounds in oral, intravenous, intramuscular and intraperitoneal routes were used to investigate the relationships of log 1/LD(50) from different exposure routes. Regression analysis shows that the log 1/LD(50) values are well correlated between intravenous and intraperitoneal or intramuscular injections. However, the correlations between oral and intravenous or intraperitoneal routes are relatively poor. Comparison of the average residuals indicates that intravenous injection is the most sensitive exposure route and oral administration is the least sensitive exposure route. This is attributed to the difference in kinetic process of toxicity testing. The toxic effect of a chemical can be similar or significantly different between exposure routes, depending on the absorption rates of chemicals into blood. Inclusion of hydrophobic parameter and fractions of ionic forms can improve the correlations between intravenous and intraperitoneal or oral routes, but not between intraperitoneal and oral routes. This is due to the differences of absorption rate in different exposure environments from different routes. Several factors, such as experimental uncertainty, metabolism and toxic kinetics, can affect the correlations between intravenous and intraperitoneal or oral routes. Copyright © 2015 Elsevier Inc. All rights reserved.

  17. Preclinical advantages of intramuscularly administered peptide A3-APO over existing therapies in Acinetobacter baumannii wound infections.

    Science.gov (United States)

    Ostorhazi, Eszter; Rozgonyi, Ferenc; Sztodola, Andras; Harmos, Ferenc; Kovalszky, Ilona; Szabo, Dora; Knappe, Daniel; Hoffmann, Ralf; Cassone, Marco; Wade, John D; Bonomo, Robert A; Otvos, Laszlo

    2010-11-01

    The designer antibacterial peptide A3-APO is efficacious in mouse models of Escherichia coli and Acinetobacter baumannii systemic infections. Here we compare the efficacy of the peptide with that of imipenem and colistin in A. baumannii wound infections after burn injury. CD-1 mice were inflicted with burn wounds and different inocula of A. baumannii, isolated from an injured soldier, were placed into the wound sites. The antibiotics were given intramuscularly (im) one to five times. Available free peptide in the blood and the systemic toxicity of colistin and A3-APO were studied in healthy mice. While toxicity of colistin was observed at 25 mg/kg bolus drug administration, the lowest toxic dose of A3-APO was 75 mg/kg. In the A. baumannii blast injury models, 5 mg/kg A3-APO improved survival and reduced bacterial counts in the blood as well as in the wounds and improved wound appearance significantly better than any other antibiotic treatment. The free peptide concentration in the blood did not reach 1 µg/mL. Peptide A3-APO, with an intramuscular therapeutic index of 15, is more efficacious and less toxic than any existing burn injury infection therapy modality against multidrug-resistant Gram-negative pathogens. A3-APO administered by the im route probably binds to a biopolymer that promotes the peptide's biodistribution.

  18. Intramuscular Olanzapine in the Management of Behavioral and Psychological Symptoms in Hospitalized Older Adults: A Retrospective Descriptive Study

    Directory of Open Access Journals (Sweden)

    Silvia Duong

    2015-01-01

    Full Text Available Background. While behavioral and psychological symptoms are frequent in hospitalized older adults with dementia or delirium, data supporting the off-label use of intramuscular atypical antipsychotics remain scarce. We examined the use of short-acting intramuscular (IM olanzapine in hospitalized older adults to manage behavioral and psychological symptoms. Methods. A retrospective observational study of inpatients 65 years or older with at least one order for olanzapine IM during admission in urban Ontario Canada was conducted. Patient demographics, prescriptions for olanzapine IM, reason for administration, perceived effectiveness, adverse events, concurrently prescribed psychotropics, comorbidities, and patient discharge destination were recorded. Results. Among 82 patients aged 65–96 years (mean ± SD 79.3 ± 7.7 85 cases were identified. Cognitive impairment or dementia affected 63.5% and 50.6% had comorbidities. Olanzapine IM was ordered 102 times and 34 patients (41% received at least one dose. The intended efficacy was achieved in 79.4% of 78 cases of 124 doses given (62.9%. Fourteen (41% patients who received doses experienced adverse events, with sedation and hypotension being the most common. Conclusions. Olanzapine IM appears effective in hospitalized older adults but is associated with potential adverse events. Structured monitoring and documentation are needed to ensure safe use in this high-risk population.

  19. Liderança e trabalho em equipe: um estudo de caso da equipe de enfermagem de um hospital geral de Belo Horizonte

    Directory of Open Access Journals (Sweden)

    Karla Rona Silva

    2011-12-01

    Full Text Available O trabalho em equipe é considerado um importante pressuposto para a reorganização do processo de trabalho. Essa modalidade visa uma abordagem mais integral, resolutiva e efetiva frente às atividades coletivas e interdisciplinares. Para a equipe de enfermagem este tipo de trabalho é de fundamental importância e depende de uma liderança capaz de gerenciar os conflitos e anseios que por ventura surgirem. Tal liderança, muitas vezes, eleita pelo próprio grupo, envolve a capacidade de influenciar pessoas. Assim, esse estudo tem por objetivo analisar o papel das lideranças e sua efetividade para o trabalho no interior de uma equipe assistencial de enfermagem. Os sujeitos da pesquisa em questão são quatro técnicos de enfermagem do setor de atendimento de urgência e emergência de um hospital geral de grande porte, localizado em Belo Horizonte. Uma vez que a questão da liderança apresenta-se, na maioria das vezes, de forma subjetiva, não sendo possível analisá-la em sua plenitude em questionários fechados, optou-se pela utilização da observação participante como principal ferramenta metodológica para coleta dos dados da pesquisa. Com o estudo, pode-se observar que a equipe, de uma forma geral, possui um bom entrosamento e uma postura ético-profissional pertinente ao desenvolvimento da assistência e do cuidado frente ao paciente. No entanto, a observação participante nos revelou a existência de uma liderança autoritária exercida por um dos membros da equipe. Apesar da insatisfação gerada nos demais membros da equipe, essa postura não prejudica o desenvolvimento do trabalho.

  20. Um sistema para o ensino e aprendizagem de algoritmos utilizando um companheiro de aprendizagem colaborativo

    OpenAIRE

    Petry, Patrícia Gerent

    2005-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-graduação em Ciência da Computação Esta dissertação apresenta um modelo computacional de um sistema de suporte ao ensino e aprendizagem no domínio de algoritmos. O sistema inclui um companheiro de aprendizagem virtual, que utiliza a Modelagem Baseada em Restrições (Constraint-Based Modelling) como forma de representação do conhecimento e raciocínio. Os Sistemas Companheiro de Aprendizagem (...

  1. Comparison between the Effects of Oral and Intramuscular Administration of Shin’iseihaito (Xinyiqingfeitang in a Streptococcus pyogenes-Induced Murine Sinusitis Model

    Directory of Open Access Journals (Sweden)

    Masaaki Minami

    2018-01-01

    Full Text Available Streptococcus pyogenes (S. pyogenes is a species of Gram-positive coccoid bacteria having many virulence factors. Its capsule and exotoxins can cause upper respiratory tract infections such as sinusitis. The general treatment for S. pyogenes-induced sinusitis is administration of antibiotics such as penicillin and macrolides; however, a serious problem associated with these antibiotics is their attenuated effect. Shin’iseihaito (Xinyiqingfeitang, a formula of Japanese traditional Kampo medicine and traditional Chinese medicine, has been used for the treatment of sinusitis. In general, formulas of Japanese traditional Kampo medicine are orally administered. This is in contrast to certain formulas of traditional Chinese medicine, which are being recently administered intramuscularly or intravenously. Regarding these traditional Chinese medicine formulas, the injection methodology is reported to be more effective than oral intake. In this study, we compared the efficacy between orally and intramuscularly administered Shin’iseihaito against S. pyogenes-induced sinusitis. We evaluated the antibacterial effect of Shin’iseihaito extract (SSHT against S. pyogenes by K-B disk diffusion assay. Furthermore, we investigated the nasal colonization of S. pyogenes, determined cytokine (TNF-α, IL-1β, and IL-6 levels, and conducted a splenocyte proliferative assay in a murine sinusitis model. SSHT displayed direct anti-S. pyogenes activity. Intramuscular administration of SSHT decreased the nasal colonization of S. pyogenes compared with oral administration. Thymidine uptake analysis revealed that the proliferation of splenocytes from S. pyogenes-infected mice under intramuscular SSHT treatment was upregulated compared to that of splenocytes from S. pyogenes-infected mice under oral SSHT treatment. We also found that TNF-α, IL-1β, and IL-6 levels in the nasal discharge from intramuscularly treated S. pyogenes-infected mice were lower than those from

  2. Estudo exploratório da demanda potencial para um sistema de compartilhamento de bicicletas pedelecs

    Directory of Open Access Journals (Sweden)

    Leonardo Dal Picolo Cadurin

    Full Text Available Resumo O objetivo deste estudo exploratório é apresentar e discutir os resultados de um procedimento para avaliar a demanda potencial por um sistema de bicicletas pedelecs compartilhadas no campus de São Carlos da Universidade de São Paulo (USP. Formado por duas áreas separadas por uma distância de 4,5 km, o campus parece ser particularmente adequado para implantação deste tipo de sistema de transporte. O procedimento proposto permite traçar um perfil do público-alvo. Permite ainda verificar a preferência entre os ônibus operados pela própria universidade e as pedelecs compartilhadas, visando os deslocamentos entre áreas. Para tanto, faz uso das técnicas de preferência declarada e redes neurais artificiais, para as etapas de coleta e análise dos dados, respectivamente. A partir das respostas de 397 estudantes foi possível identificar que o esforço físico, condições meteorológicas, tempo de viagem e ausência de ciclovias são fatores que restringem o uso de bicicletas convencionais. Lotação excessiva, horários de partida fixos, ausência de controle sobre o início da viagem e distância de caminhada são aspectos importantes para as pessoas não utilizarem os ônibus operados pela USP. Sobre a preferência por pedelecs, a escolha é influenciada pela presença de ciclovias/ciclofaixas, da lotação do ponto de ônibus da USP e das condições meteorológicas.

  3. Intramuscular Artesunate for Severe Malaria in African Children: A Multicenter Randomized Controlled Trial.

    Directory of Open Access Journals (Sweden)

    Peter G Kremsner

    2016-01-01

    Full Text Available Current artesunate (ARS regimens for severe malaria are complex. Once daily intramuscular (i.m. injection for 3 d would be simpler and more appropriate for remote health facilities than the current WHO-recommended regimen of five intravenous (i.v. or i.m. injections over 4 d. We compared both a three-dose i.m. and a three-dose i.v. parenteral ARS regimen with the standard five-dose regimen using a non-inferiority design (with non-inferiority margins of 10%.This randomized controlled trial included children (0.5-10 y with severe malaria at seven sites in five African countries to assess whether the efficacy of simplified three-dose regimens is non-inferior to a five-dose regimen. We randomly allocated 1,047 children to receive a total dose of 12 mg/kg ARS as either a control regimen of five i.m. injections of 2.4 mg/kg (at 0, 12, 24, 48, and 72 h (n = 348 or three injections of 4 mg/kg (at 0, 24, and 48 h either i.m. (n = 348 or i.v. (n = 351, both of which were the intervention arms. The primary endpoint was the proportion of children with ≥ 99% reduction in parasitemia at 24 h from admission values, measured by microscopists who were blinded to the group allocations. Primary analysis was performed on the per-protocol population, which was 96% of the intention-to-treat population. Secondary analyses included an analysis of host and parasite genotypes as risks for prolongation of parasite clearance kinetics, measured every 6 h, and a Kaplan-Meier analysis to compare parasite clearance kinetics between treatment groups. A post hoc analysis was performed for delayed anemia, defined as hemoglobin ≤ 7 g/dl 7 d or more after admission. The per-protocol population was 1,002 children (five-dose i.m.: n = 331; three-dose i.m.: n = 338; three-dose i.v.: n = 333; 139 participants were lost to follow-up. In the three-dose i.m. arm, 265/338 (78% children had a ≥ 99% reduction in parasitemia at 24 h compared to 263/331 (79% receiving the five-dose i

  4. Hipospadia perineal em um cão: relato de caso

    Directory of Open Access Journals (Sweden)

    F.S. Valente

    2014-06-01

    Full Text Available A hipospadia é uma anomalia congênita da genitália externa, na qual a uretra peniana termina ventral e caudalmente à sua abertura normal. Pode ser classificada, com base na localização da abertura uretral, como glandular, peniana, escrotal, perineal e anal. O objetivo deste trabalho é relatar um caso raro de hipospadia perineal, em que são abordados seus aspectos clínicos e terapêuticos, em um cão macho, sem raça definida, com seis meses de idade. Um canino com histórico de suspeita de hermafroditismo e presença de um orifício, logo abaixo do ânus, pelo qual urinava foi atendido no Hospital de Clínicas Veterinárias da Universidade Federal do Rio Grande do Sul (UFRGS. Durante o exame físico, foi observado o meato uretral localizado ventralmente ao ânus, além de alterações no prepúcio, pênis e escroto. Foram realizados exames de triagem, tais como: hemograma completo, urinálise, ecografia abdominal e uretrocistografia. O cão foi encaminhado para a cirurgia, quando foi submetido à amputação peniana e prepucial total e também à orquiectomia. O canino recebeu antibioticoterapia, analgésicos, anti-inflamatório e limpezas diárias dos pontos e da região perineal e apresentou excelente recuperação pós-operatória. Após 30 dias da cirurgia, o paciente retornou ao hospital, e foi verificada completa cicatrização da ferida cirúrgica, sem sinais de infecção urinária e inflamação ou assaduras na região perineal. A hipospadia perineal é um caso raro de anomalia uretral congênita, ainda pouco documentada em medicina veterinária. O procedimento cirúrgico realizado demonstrou ser importante, uma vez que removeu toda a genitália externa defeituosa, onde, futuramente, poderiam desenvolver-se infecções e/ou inflamações. Com isso, minimizou as complicações dessa doença e melhorou a qualidade de vida do paciente.

  5. Violência doméstica psicológica sob a perspectiva da mulher idosa: um enfoque na fenomenologia social

    OpenAIRE

    Rafaella Queiroga Souto

    2014-01-01

    Introdução: A violência doméstica psicológica perpetrada pelo familiar contra a mulher idosa é uma importante e pouco pesquisada questão de saúde pública global. Objetivo: Compreender a experiência da mulher idosa que vivencia violência doméstica psicológica. Método: Pesquisa qualitativa ancorada pela fenomenologia social de Alfred Schütz, realizada com onze mulheres idosas identificadas nos registros de dois serviços localizados no município de Campina Grande, Paraíba e um serviço localizado...

  6. Análise de um sistema de aquecimento de água para residências rurais, utilizando energia solar

    OpenAIRE

    Basso,Luiz H.; Souza,Samuel N. M. de; Siqueira,Jair A. C.; Nogueira,Carlos E. C.; Santos,Reginaldo F.

    2010-01-01

    A conscientização da importância do meio ambiente tem incentivado o estudo de novas fontes energéticas renováveis e menos poluentes. Dentre essas fontes, a energia solar destaca-se por ser perene e limpa. A utilização da energia solar em sistemas de aquecimento de água residencial rural pode colaborar com a economia de energia elétrica, base da matriz energética brasileira. Conhecer os fatores que influenciam na operação de um sistema de aquecimento de água por energia solar é importante na d...

  7. O GERENCIAMENTO DO RELACIONAMENTO COM FORNECEDORES NA INTEGRAÇÃO DA CADEIA DE SUPRIMENTOS: UM ESTUDO DE CASO NA INDÚSTRIA ELETRO-MECÂNICA

    OpenAIRE

    Almeida, Marly Mizue Kaibara de; Marins, Fernando Augusto Silva; Tramarico, Claudemir Leif

    2012-01-01

    O aumento da competição, a globalização e a necessidade de redução do ciclo de produção e níveis de estoques criou a necessidade de processos baseados em alianças eficazes na cadeia de suprimentos. Estas pressões têm levado os gestores a reverem suas empresas individualmente e analisar sua posição na cadeia de suprimentos. O Gerenciamento da Cadeia de Suprimentos representa uma importante evolução nas práticas de relacionamento entre clientes e fornecedores participantes de um mesmo canal de ...

  8. Agripec : um modelo para estimar custos economicos e emissões de gases efeito-estufa para a pecuaria bovina brasileira

    OpenAIRE

    Costa, Thelmo Vergara de Almeida Martins

    2011-01-01

    A criação bovina é um importante emissor de Gases Efeito Estufa (GEE) do Brasil. A maior parte das emissões de metano vem da fermentação entérica, resultado normal do processo digestivo dos animais ruminantes como os bovinos. No entanto, a tarefa de analisar a contribuição da pecuária bovina nas emissões de GEEs necessita da identificação dos contextos regionais em que ocorrem os diferentes sistemas de produção no Brasil. Assim, para se comparar diferentes sistemas produtivos, é necessário se...

  9. Gestão de marcas por meio das redes sociais: um estudo sobre a utilização do facebook

    OpenAIRE

    Flávia Preuss Siqueira Batista

    2011-01-01

    Este estudo aborda a utilização das mídias sociais como ferramenta para gestão de marcas. O tema se demonstra relevante por tratar de três assuntos considerados importantes na atualidade: gestão de marcas, marketing de relacionamento e redes sociais no ambiente virtual. A proposta do estudo é explorar se as organizações estão estabelecendo um relacionamento com seus clientes de forma que este promova o brand equity por meio do uso das redes sociais. Para se atingir os objetivos do estudo, foi...

  10. Práticas de Gestão de Recursos Humanos nas PME: um estudo multi-caso no concelho de Alcácer do Sal

    OpenAIRE

    Felisardo, Alexandra Sofia dos Santos

    2015-01-01

    Dissertação apresentada para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Ciências Empresariais - Ramo gestão de PME Num contexto cada vez mais competitivo, a gestão de recursos de recursos humanos assume um papel cada vez mais importante na criação de vantagem competitiva sustentável, uma vez que os trabalhadores são a base de qualquer empresa. No entanto, nem todas as empresas, principalmente as pequenas e médias empresas (PME), compreendem a sua importância,...

  11. Casey Heynes: estudo semiótico de um caso de bullying registrado em vídeo

    Directory of Open Access Journals (Sweden)

    Isabel Cristina Vieira Coimbra Diniz

    2012-04-01

    Full Text Available O registro audiovisual de um conflito entre estudantes australianos, Casey Heynes (http://www.youtube.com/watch?v=eyVilspkzBg, ficou conhecido mundialmente por meio da difusão em sites de compartilhamento de vídeos. As imagens apresentam a agressão a um estudante que reage subitamente, e, com uma força inesperada, derruba o agressor. As imagens impressionaram o mundo e levantaram uma importante discussão nas escolas, alertando pais e professores sobre um tipo de violência conhecida como bullying. Neste trabalho, analisa-se, sob a perspectiva da semiótica de linha francesa, o acontecimento como sequência de ações e reações que constroem diferentes sentidos no processo enunciativo. A partir da investigação do plano do conteúdo, privilegiamos o nível narrativo do percurso gerativo de sentido, especialmente o percurso da paixão. Dessa forma, pela confrontação entre sujeito agressor e sujeito agredido na relação homem-mundo, vislumbram-se percursos passionais em que se pode tangenciar, pelas categorias aspectuais, as gradações que particularizam o bullying no vídeo citado.

  12. Análise da percepção e complexidade ambiental de profissionais de um Curso de Ecoturismo

    Directory of Open Access Journals (Sweden)

    Vanessa Andretta

    2014-06-01

    Full Text Available Estudar a relação entre homem e natureza, bem como propor soluções que conduzam à conscientização ambiental, é um desafio para os pesquisadores. Uma importante ferramenta para estimular a conscientização ambiental é o ecoturismo. Identificar e analisar a percepção ambiental dos profissionais envolvidos com o ecoturismo permite compreender a relação com a natureza desses possíveis multiplicadores da conscientização ambiental. O presente trabalho descreve um estudo sobre a teoria da complexidade ambiental e a percepção ambiental e de uma série de profissionais que cursaram Pós-Graduação Lato Sensu à distância em Ecoturismo da Universidade Federal de Lavras, entre os anos de 2004 e 2007. Diagnosticou-se que os indivíduos analisados são capazes de perceber e apontar diversos problemas ambientais, mas pouco se responsabilizam por eles e, tampouco, envolvem-se em ações conservacionistas. Nesse contexto, um esquema de raciocínio é proposto, de tal forma que a percepção ambiental seja associada à teoria da complexidade ambiental, com o intuito de motivar raciocínios e ações conservacionistas nas atividades cotidianas desses profissionais. Certamente, aproximação similar pode ser estendida a outros grupos de indivíduos.

  13. Pesquisa qualitativa em Educação Matemática a distância: aspectos importantes do uso do Role Playing Game como procedimento metodológico de pesquisa Qualitative research in distance Mathematics Education: important aspects of the Role Playing Game as research methodological procedure

    Directory of Open Access Journals (Sweden)

    Maurício Rosa

    2012-09-01

    Full Text Available Este artigo evidencia aspectos do Role Playing Game (RPG, jogo de representação de personagens, que o tornam um importante procedimento de investigação em termos de Pesquisa Qualitativa em Educação (no caso, Educação Matemática a Distância. Esse jogo foi adotado em uma pesquisa (ROSA, 2008 que estudou as relações estabelecidas entre a construção de identidades online e o ensino e a aprendizagem do conceito de Integral Definida (conceito do Cálculo Diferencial e Integral em um curso a distância. Assim, a partir dessa investigação que utilizou o RPG jogado a distância, via chat, como procedimento de coleta de dados, discutimos a inserção desse jogo como procedimento metodológico de pesquisa em Educação Matemática a Distância e caracterizamos como esse processo liga-se a questões referentes à Pesquisa Qualitativa nesse novo cenário: o ciberespaço. Logo, assumimos que adotar o RPG como procedimento de pesquisa favorece tanto o pesquisador, quanto os sujeitos investigados, em termos de mostrarem-se como "diferentes" mesmo sendo "os mesmos" (ROSA, 2008 e isso potencializa a produção do conhecimento matemático, bem como a análise das ações e possibilidades educacionais vislumbradas pelo ser online que se apresenta no ambiente natural apresentado. Também apontamos a adoção do RPG como fator que impele e amplia a concepção pós-estruturalista de Educação que, em ambientes virtuais, cada vez mais, vem destacando e estabelecendo uma amplitude de investigação que transforma esse espaço imaginativo e surpreendente em um ambiente natural de pesquisa.This article highlights aspects of the Role Playing Game (RPG, which make an important procedure in terms of research on Qualitative Research in Distance Education (in this case, Mathematics Education. This game was used in a research (ROSA, 2008 that studied the relations between the construction of online identities and teaching and learning of the concept of

  14. Turismo médico em Portugal : análise de viabilidade do desenvolvimento de um operador turístico

    OpenAIRE

    Pereira, Joana Santos Brilha, 1990-; Antão, Mário Alexandre Guerreiro, 1965-

    2016-01-01

    Lusíada. Economia & Empresa. - ISSN 1645-6750. - S. 2, n. 20 (2016). - p. 61-79 Este estudo visa um dos sectores de atividade económica mais importantes para Portugal; a indústria turística. Propõe incidir a sua análise sobre o conceito de Turismo Médico, através da análise da viabilidade da criação de um operador turístico especializado, não esquecendo a importância dos demais factores para o aparecimento e desenvolvimento do Turismo Médico em Portugal. Pretende-se compreender de que f...

  15. Viabilidade hidro-sedimentológica de um canal de maré projetado no oeste da Lagoa de Araruama – RJ

    OpenAIRE

    Silva, Rodrigo Amado Garcia; Rosman, Paulo Cesar Colonna

    2016-01-01

    RESUMO A Lagoa de Araruama, maior laguna hipersalina do Brasil, é um importante sistema estuarino situado na Região dos Lagos, sudeste do estado do Rio de Janeiro. A lagoa tem forma oblonga, estendendo-se por cerca de 40 km de oeste a leste em seu eixo maior. Por apresentar um balanço hídrico negativo e apenas uma ligação com o mar, através do longo Canal de Itajuru em sua extremidade leste, a laguna apresenta pouquíssima renovação de águas, o que a torna naturalmente propensa a eutrofização....

  16. Perfil clínico-epidemiológico dos pacientes internados na clínica pediátrica em um hospital universitário

    OpenAIRE

    José Sávio Menezes Parente; Francisco Ranilson Alves Silva

    2017-01-01

    Introdução: a infância é um período de grande importância na formação do ser humano, logo, um episódio de doença pode interromper esse processo, além de interferir na estrutura familiar e gerar ônus ao sistema de saúde. A epidemiologia e a morbidade atuam como importantes instrumentos, pois promovem o conhecimento em saúde e auxiliam na distribuição dos recursos, alcançando os vários níveis administrativos. Porém, estudos que envolvem o perfil de internações pediátricas ainda são escassos. O ...

  17. Educação para a saúde junto a um grupo de adolescentes: relato de uma experiência de estudantes de enfermagem

    Directory of Open Access Journals (Sweden)

    Yara Perez Martins

    1985-12-01

    Full Text Available Trata-se da abordagem sobre a elaboração de um programa de Educação em Saúde, para um grupo de adolescentes. Tomou-se como base o referencial teórico sobre pesquisa-ação para se definir os procedimentos do trabalho. Para tanto, vêm-se desenvolvendo reuniões semanais com o grupo de adolescentes, nas quais a participação destes tem demonstrado que o medo, a vergonha, a insegurança, decorrentes da desinformação sobre saúde e a privação de contatos reais com a pessoa do outro, se constituem em importantes indicadores que dificultam o viver sadio dos adolescentes.

  18. Avaliação de um sistema de tratamento de águas cinzas em edificação de campus universitário

    OpenAIRE

    Mariana Cardoso Chrispim

    2014-01-01

    O reúso de água é um instrumento importante que contribui para a redução da pressão sobre os mananciais e para redução do consumo de água potável para fins que não requeiram água de padrão potável. Neste contexto, o presente estudo teve como objetivo principal analisar um sistema de coleta e tratamento de águas cinzas provenientes de pias de banheiro, chuveiros e máquina de lavar roupas tendo em vista o reúso não-potável em edificações. Os objetivos específicos foram: caracterizar qualitativa...

  19. Césio-137, um drama recontado

    OpenAIRE

    Vieira,Suzane de Alencar

    2013-01-01

    O acidente radiológico com césio-137, desencadeado na cidade de Goiânia no ano 1987, não se encerra com o fim da contaminação radiológica e se estende a um processo judicial, médico-científico e narrativo de identificação e reconhecimento de novas vítimas. O drama ocupa um lugar central na dinâmica do evento radiológico ao estender seus limites, modular sua intensidade e atualizá-lo a cada nova narrativa. A etnografia, enquanto uma narrativa sobre o evento, incorpora e atualiza o drama como m...

  20. Vieira: o profeta de um outro apocalipse

    Directory of Open Access Journals (Sweden)

    Maria theresa Abelha Alves

    1998-03-01

    Full Text Available As crenças di fundidas pelas obras proféticas de Antônio Vieira orquestram a religião, a utopia e apoiesis, configurando-se como ecostardios da unificação qa realidade que deixou esperançoso o mundorenascentista. Antônio Vieira, como revelador dos segredos bíblicos, ecomo intérprete das trovas messiânicas de Bandarra, expõe o sentidoapoca líptico da história, anunciando o advento de um novo império,renovador das paradisíacas delícias, sob o poder temporal de um re1português e sob o poder espiritual de Cristo.

  1. Luiz Gama: um abolicionista leitor de Renan

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    Ligia Fonseca Ferreira

    2007-08-01

    Full Text Available O hisoriador e filósofo Ernest Renan exerceu grande influência, hoje um tanto esquecida, sobre uma boa parte da elite intelectual brasileira engajada em reformas e movimentos que caracterizam a transição da Monarquia para a República. Dentre eles, destaca-se o abolicionista Luiz Gama, caso único de um ex-escravo autodidata que alcança projeção no cenário político e na República das Letras. Leitor precoce de Vida de Jesus, obra seminal do pensador francês, o advogado dos escravos é um dos primeiros a referir-se à obra que contou com inédita tradução brasileira, pouco depois de sua publicação na França. Por fim, observamos a apropriação das idéias renanianas por parte de personalidades diversas do ponto de vista social e racial, estabelecendo um paralelo entre Luiz Gama e Joaquim Nabuco.Historian and philosopher Ernest Renan exerts great influence - today somewhat forgotten - on a large part of the Brazilian intellectual elite that is engaged in reforms and movements which characterize the transition of a Monarchy to a Republic. Among these, abolitionist Luiz Gama stands out as the sole case of a former autodidact slave, who achieves a projection in the political scenario, and in the Republic of Letters. An early reader of Vida de Jesus, a seminal work of the French philosopher, the slaves’ attorney is one of the first to refer to the work, which counted with a first-hand, unprecedented Brazilian translation, shortly after its publication in France. Finally, we shall see the appropriation of Renanian ideas on the part of various personalities from the social and racial point of view, while establishing a parallel between Luiz Gama and Joaquim Nabuco.

  2. Um Visitante do Rio de Janeiro Colonial

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    Jean M. Carvalho França

    1997-01-01

    Full Text Available O texto que se segue é a tradução de um manuscrito francês, intitulado Relâche du Vaisseau L'Arc-en-ciel à Rio de Janeiro, 1748, que se encontra na Biblioteca da Ajuda, em Lisboa. Trata-se de um relato anônimo, que dá conta da passagem do navio francês L'Arc-en-ciel pelo porto carioca. Tal relato, um curioso documento para a história dos nossos costumes, contém uma descrição da baía da Guanabara e da cidade do Rio de Janeiro, uma pequena análise do caráter da gente portuguesa do Brasil, um perfil do Governador Dom Fernando Freire e algumas considerações gerais sobre a situação do porto local e sobre os víveres disponíveis na região.The following text is a translation of a French manuscript named Relachê du Vaisseau L'Arc-en-ciel à Rio de Janeiro, 1748, which is in Biblioteca da Ajuda (Ajuda Library in Lisbon. It is an anonymous report and relates the stay of the French ship L'Arc-en-ciel in Rio de Janeiro harbour. Such report, a curious document for the history of our customs, has a description of Guanabara bay and Rio de Janeiro city, a brief analysis of the character of the Portuguese people in Brazil, a prolife of Governor Dom Fernando Freire and some considerations of the situation of local harbour and on the provisions available in that region.

  3. Paralisia periodica tireotoxica: registro de um caso

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    Athos Scherer Torres

    1979-06-01

    Full Text Available É relatado um caso de paralisia periódica tireotóxica. Os autores chamam a atenção para o fato de não haver registro de publicações semelhantes na literatura brasileira nos 10 últimos anos. São abordados diversos aspectos do diagnóstico diferencial com outros tipos de paralisia periódica.

  4. Um romance interdisciplinar revolucionário

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    Álvaro Cardoso Gomes

    2015-11-01

    Full Text Available Este artigo analisa o romance No hospício, de Rocha Pombo, procurando mostrar como o autor envereda pelo experimentalismo romanesco, o que o leva a criar uma obra revolucionária. Impregnando sua ficção com reflexões estéticas, metafísicas e a poesia, o autor criou um romance inovador que reflete as grandes inquietações do Simbolismo, no final do século XIX.

  5. No protection in chickens immunized by the oral or intra-muscular immunization route with Ascaridia galli soluble antigen

    DEFF Research Database (Denmark)

    Andersen, Janne Pleidrup; Norup, Liselotte R.; Dalgaard, Tina S.

    2013-01-01

    In chickens, the nematode Ascaridia galli is found with prevalences of up to 100% causing economic losses to farmers. No avian nematode vaccines have yet been developed and detailed knowledge about the chicken immune response towards A. galli is therefore of great importance. The objective...... of this study was to evaluate the induction of protective immune responses to A. galli soluble antigen by different immunization routes. Chickens were immunized with a crude extract of A. galli via an oral or intra-muscular route using cholera toxin B subunit as adjuvant and subsequently challenged with A...... immunization had an effect on both Th1 and Th2 cytokines in caecal tonsils and Meckel's diverticulum. Thus both humoral and cellular immune responses are inducible by soluble A. galli antigen, but in this study no protection against the parasite was achieved....

  6. Modeling the growth dynamics of multiple Escherichia coli strains in the pig intestine following intramuscular ampicillin treatment

    DEFF Research Database (Denmark)

    Ahmad, Amais; Zachariasen, Camilla; Christiansen, Lasse Engbo

    2016-01-01

    using a mathematical model to simulate the competitive growth of E. coli strains in a pig intestine under specified plasma concentration profiles of ampicillin. Results : In vitro growth results demonstrated that the resistant strains did not carry a fitness cost for their resistance, and that the most...... with ampicillin resistance in E. coli. Besides dosing factors, epidemiological factors (such as number of competing strains and bacterial excretion) influenced resistance development and need to be considered further in relation to optimal treatment strategies. The modeling approach used in the study is generic......Background : This study evaluated how dosing regimen for intramuscularly-administered ampicillin, composition of Escherichia coli strains with regard to ampicillin susceptibility, and excretion of bacteria from the intestine affected the level of resistance among Escherichia coli strains...

  7. A Randomized controlled trial on safety and efficacy of single intramuscular versus staggered oral dose of 600 000IU Vitamin D in treatment of nutritional rickets.

    Science.gov (United States)

    Mondal, Krishanu; Seth, Anju; Marwaha, Raman K; Dhanwal, Dinesh; Aneja, Satinder; Singh, Ritu; Sonkar, Pitambar

    2014-06-01

    Comparison of efficacy and safety of two different regimens of vitamin D-600 000 IU as a single intramuscular dose, and 60 000IU orally once a week for 10 weeks-in treatment of nutritional rickets. Children with nutritional rickets (age: 0.5-5 years, n = 61) were randomized to receive either 60 000IU vitamin D orally once a week for 10 weeks or 600 000IU single intramuscular injection. Serum calcium, phosphate, alkaline phosphatase, urinary calcium/creatinine ratio, serum 25 hydroxy vitamin D and radiological score were compared at 12-week follow-up. No difference was found in efficacy of the two regimens on comparing biochemical and radiological parameters. Serum 25 hydroxy vitamin D >100 ng/ml was found in two children in the oral group and one child in the intramuscular group. No child developed hypercalcemia or hypercalciuria after starting treatment. Staggered oral and one-time intramuscular administrations of 600 000IU vitamin D are equally effective and safe in treatment of nutritional rickets. © The Author [2014]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  8. Intramuscular adrenaline does not reduce the incidence of respiratory distress and hypoglycaemia in neonates delivered by elective caesarean section at term

    DEFF Research Database (Denmark)

    Pedersen, Pernille; Avlund, O L; Pedersen, B L

    2008-01-01

    AIM: To test whether intramuscular injection of 30 microg adrenaline decreased the incidence of respiratory distress and hypoglycaemia in term infants delivered by elective caesarean section before active labour. METHOD: The study was randomised and double-blinded. A total of 270 neonates were...

  9. A COMPARATIVE-STUDY OF ELECTROMYOGRAMS OF THE MASSETER, TEMPORALIS, AND ANTERIOR DIGASTRIC MUSCLES OBTAINED BY SURFACE AND INTRAMUSCULAR ELECTRODES - RAW-EMG

    NARCIS (Netherlands)

    KOOLE, P; DEJONGH, HJ; BOERING, G

    Electromyographic activity was synchronously recorded by surface and intramuscular electrodes in the same muscle. The activity of the left masseter, left temporalis, and both bellies of the anterior digastric muscle was studied by this double registration technique. In rest position no

  10. Ultrastructural localisation of intramuscular expression of BDNF mRNA by silver-gold intensified non-radioactive in situ hybridisation

    NARCIS (Netherlands)

    Liem, RSB; Brouwer, N; Copray, JCVM

    2001-01-01

    A non-radioactive in situ hybridisation method is described for the detection of low intramuscular levels of brain-derived neurotrophic factor (BDNF) mRNA at the electron microscope level. Application of high-grade silver-gold intensification of the diaminobenzidine end product of in situ

  11. Treatment with intramuscular vascular endothelial growth factor gene compared with placebo for patients with diabetes mellitus and critical limb ischemia : A double-blind randomized trial

    NARCIS (Netherlands)

    Kusumanto, YH; Van Weel, [No Value; Mulder, NH; Smit, AJ; Van den Dungen, JJAM; Hooymans, JMM; Sluiter, WJ; Tio, RA; Quax, PHA; Gans, ROB; Dullaart, RPF; Hospers, GAP

    Despite advances in revascularization techniques, limb salvage and relief of pain cannot be achieved in many diabetic patients with diffuse peripheral vascular disease. Our objective was to determine the effect of intramuscular administration of phVEGF(165) (vascular endothelial growth factor

  12. Application of kidney inhibition swab tests to evaluate penicillin-G residues in sow tissues and body fluids following intramuscular injection

    Science.gov (United States)

    Kidney inhibition swab (KIS) tests, recently adapted by the US FSIS for antibiotics on-site screening, were employed to evaluate the depletion of penicillin-G residues from kidney, liver, muscle, serum, and urine of sows after intramuscular (IM) penicillin-G procaine administration. Sows (n=130; 22...

  13. Administration of imatinib mesylate in rats impairs the neonatal development of intramuscular interstitial cells in bladder and results in altered contractile properties.

    Science.gov (United States)

    Gevaert, Thomas; Hutchings, Graham; Everaerts, Wouter; Prenen, Hans; Roskams, Tania; Nilius, Bernd; De Ridder, Dirk

    2014-04-01

    The KIT receptor is considered as a reliable marker for a subpopulation of interstitial cells (IC), and by persistent neonatal inhibition of KIT we have investigated the role of this receptor in the development of IC-networks in bladder and we have observed the functional consequences of this inhibition. Newborn rat pups were treated daily with the KIT inhibitor imatinib mesylate (IM). After 7 days animals were sacrificed and bladder samples were dissected for morphological and functional studies. Morphological research consisted of immunohistochemistry with IC specific antigens (KIT and vimentin) and electron microscopy. The functional studies were based on isolated bladder strips in organ baths, in which spontaneous bladder contractility and the response to a non-subtype selective muscarinic agonist was evaluated. Suburothelial and intramuscular IC were found and characterized in neonatal rat bladder. IM-treatment induced a significant decrease in numbers of IC based on specific immunohistochemical markers, and electron microscopy revealed evidence of IC cell injury. These morphological alterations were observed on intramuscular IC only and not on IC in the suburothelium. Isolated muscle strips from IM-treated animals had a lower contractile frequency and an altered response to muscarinic agonists. The present study shows the presence of regional subpopulations of IC in neonatal rat bladder, provides evidence for a dependence on KIT of the development of intramuscular IC and supports the hypothesis that a poor development of networks of intramuscular IC might have repercussions on spontaneous and muscarinic-induced bladder contractility. © 2013 Wiley Periodicals, Inc.

  14. The effect of adipocyte and heart fatty acid-binding protein genes on intramuscular fat and backfat content in Meishan crossbred pigs

    NARCIS (Netherlands)

    Gerbens, F.; Koning, de D.J.; Harders, F.L.; Meuwissen, T.H.E.; Groenen, M.A.M.; Veerkamp, R.L.; Arendonk, van J.A.M.; Pas, te M.F.W.

    2000-01-01

    Effects of genetic variation in porcine adipocyte and heart fatty acid-binding protein genes, A-FABP and H-FABP, respectively, on intramuscular fat (IMF) content and backfat thickness (BFT) were examined in F2 crossbreds of Meishan and Western pigs. The involvement of each FABP gene in IMF accretion

  15. Acupuncture Compared with Intramuscular Injection of Neostigmine for Postpartum Urinary Retention: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

    Directory of Open Access Journals (Sweden)

    Xiao-Mei Wang

    2018-01-01

    Full Text Available Objective. To compare the effectiveness and safety of acupuncture versus intramuscular injection of neostigmine. Methods. Databases including CNKI, VIP, WanFang, SinoMed, PubMed, Cochrane Library, and clinicaltrials.gov database were retrieved for relevant literature, with the retrieval deadline being November 2017. Two reviewers independently screened, selected, and extracted data and validated the results. The methodological quality was evaluated with the “Risk of Bias” tool, and the meta-analysis was performed by using the RevMan 5.3.5 software. Results. Totally 953 patients with postpartum urinary retention from 15 randomized controlled trials entered the meta-analysis. 12 articles compared the clinical cure rate of acupuncture alone versus intramuscular injection of neostigmine and found the cure rate in the acupuncture group was 2 times that in the neostigmine group (RR, 1.91; 95% CI: 1.66–2.19. 15 articles compared the clinical effectiveness rate of acupuncture alone with that of intramuscular injection of neostigmine and found the clinical effectiveness rate was 28% higher in the acupuncture group than in the neostigmine group (RR: 1.28; 95% CI: 1.16–1.42. No adverse event was reported in the acupuncture group. Conclusion. Acupuncture alone is more effective in treating postpartum urinary retention than intramuscular injection of neostigmine, with good safety profile. Therefore, it is a feasible and valuable technique in clinical settings.

  16. O caso Paco: um exemplo de neodesencadeamento

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    Elizabete Siqueira

    2011-08-01

    Full Text Available Este trabalho é produto de uma investigação empreendida sobre Oestatuto contemporâneo das identificações em sujeitos com marcas e alterações corporais, no Programa de Pós-graduação em Psicologia Clínica da Universidade Católica de Pernambuco. Foram estudados os depoimentos coletados em outra pesquisa realizada no âmbito da Antropologia pela pesquisadora Fabiana Maria Gama Pereira, intitulada Tatuagens, piercings e outras marcas corporais: aproximações interetnográficas entre Recife e Madri. A metodologia utilizada foi a meta-análise. Os relatos de quatro sujeitos que submeteram seus corpos a alterações corporais foram analisados com base nos pressupostos da psicanálise. Eles foram divididos em dois grupos: o primeiro, composto por três sujeitos que marcam seus corpos para o Outro em busca de reconhecimento; e o outro, por um sujeito que ancora seu ser em suas modificações corporais e tem uma modalidade identificatória peculiar a uma insígnia de gozo. Nosso objetivo é demonstrar que o caso do sujeito do segundo grupo representa um exemplo paradigmático de um neodesencadeamento psicótico.

  17. La legitimación de la Ciencia social en las bases de datos científicas más importantes para América Latina

    OpenAIRE

    Morales Gaitán, Katia Andrea; Aguado López, Eduardo

    2010-01-01

    Se analizan desde la Sociología de la ciencia tres ejes de su campo. El primero, rescata la epistemología de la producción científica social. El segundo, trata la construcción de la legitimidad de los científicos a través de sus publicaciones. El tercero, refiere el estudio de los indicadores más importantes para América Latina generados por la Cienciometría. Se concluye que la incorporación de las Tecnologías de Información y Comunicación son canales a través de los cuales se legitiman los r...

  18. Cardiovascular, respiratory and sedative effects of intramuscular alfaxalone, butorphanol and dexmedetomidine compared with ketamine, butorphanol and dexmedetomidine in healthy cats.

    Science.gov (United States)

    Cremer, Jeannette; Riccó, Carolina H

    2017-11-01

    Objectives The aim of the study was to evaluate the cardiorespiratory effects, quality of sedation and recovery of intramuscular alfaxalone-dexmedetomidine-butorphanol (ADB) and ketamine-dexmedetomidine-butorphanol (KDB), in cats. Methods Nine adult, healthy cats (6.63 ± 1.42 kg) were enrolled in a blinded, randomized, crossover experimental design. Cats were sedated twice intramuscularly, once with ADB (alfaxalone 1 mg/kg, dexmedetomidine 0.005 mg/kg, butorphanol 0.2 mg/kg), and once with KDB (ketamine 5 mg/kg, dexmedetomidine 0.005 mg/kg, butorphanol 0.2 mg/kg), in random order. Data collected included heart rate (HR), arterial blood pressure and blood gas analysis, respiratory rate, and sedation score. Analysis of variance with Bonferroni post-hoc correction was used for parametric data, and a Wilcoxon signed rank test was used for non-parametric data. Significance was set at P <0.05. Results Total sedation time was shorter for ADB (90.71 ± 15.12 mins vs 147.00 ± 47.75 mins). Peak sedation was observed within 15 mins in both groups. Quality of recovery was excellent in both groups. HR decreased over time in both groups. Diastolic and mean arterial pressure decreased over time for ADB, becoming significant after 30 mins. All cardiovascular variables were within the clinically acceptable range in both groups. Arterial partial pressure of oxygen was significantly decreased from baseline for KDB at all time points (73 ± 2.5 mmHg [9.7 ± 0.3 kPa] vs ADB 83 ± 2.6 mmHg [11 ± 0.3 kPa]). Hypoventilation was not observed. Conclusions and relevance Both protocols produced acceptable cardiovascular stability. Sedation and recovery quality were good, albeit sedation was shorter with ADB. Although oxygenation was better maintained in the ADB group, all sedated cats should receive oxygen supplementation.

  19. Survey of SSC12 regions affecting fatty acid composition of intramuscular fat using high density SNP data

    Directory of Open Access Journals (Sweden)

    María eMuñoz

    2012-01-01

    Full Text Available Fatty acid composition is a critical aspect of pork because it affects sensorial and technological aspects of meat quality and it is relevant for human health. Previous studies identified significant QTLs in porcine chromosome 12 for fatty acid profile of backfat and intramuscular fat. In the present study, 374 SNPs mapped in SSC12 from the 60K Porcine SNP Beadchip were used. We have combined linkage and association analyses with expression data analysis in order to identify regions of SSC12 that could affect fatty acid composition of intramuscular fat in longissimus muscle. The QTL scan showed a region around the 60 cM position that significantly affects palmitic fatty acid and two related fatty acid indexes. The Iberian QTL allele increased the palmitic content (+2.6% of mean trait. This QTL does not match any of those reported in the previous study on fatty acid composition of backfat, suggesting different genetic control acting at both tissues. The SNP association analyses showed significant associations with linolenic and palmitic acids besides several indexes. Among the polymorphisms that affect palmitic fatty acid and match the QTL region at 60 cM, there were three that mapped in the Phosphatidylcholine Transfer Protein (PCTP gene and one in the Acetyl-CoA Carboxylase  gene (ACACA. Interestingly one of the PCTP SNPs also affected significantly unsaturated and double bound indexes and the ratio between polyunsaturated/monounsaturated fatty acids. Differential expression was assessed on longissimus muscle conditional on the genotype of the QTL and on the most significant SNPs, according to the results obtained in the former analyses. Results from the microarray expression analyses, validated by RT-qPCR, showed that PCTP expression levels significantly vary depending on the QTL as well as on the own PCTP genotype. The results obtained with the different approaches point out the PCTP gene as a powerful candidate underlying the QTL for

  20. Population pharmacokinetics of methadone hydrochloride after a single intramuscular administration in adult Japanese sika deer (Cervus nippon nippon).

    Science.gov (United States)

    Scala, Christopher; Marsot, Amélie; Limoges, Marie-Josée; Locatelli, Yann; Simon, Nicolas; Alvarez, Jean-Claude

    2015-03-01

    To assess the population pharmacokinetics of methadone in deer. Prospective non-randomized experimental trial. Twelve healthy adult sika deer (nine males and three females). Deer received intramuscular administration of racemic methadone hydrochloride at 0.5 mg kg(-1) or 1 mg kg(-1) . Plasma methadone and its metabolite 2-Ethylidene-1,5-Dimethyl-3,3-Diphenyl-Pyrolidine (EDDP) concentrations were determined by validated liquid chromatography coupled to tandem mass spectrometry methods, at times 0, 30 minutes, 1, 2, 3, 4, 5, 6, 8, 12 and 24 hours. Population pharmacokinetics analysis was undertaken using a non-linear mixed effects modelling (NONMEM). A two-compartment linear disposition model best described observed time-concentration profiles of methadone and EDDP. Population parameter estimates of methadone were elimination clearance (17.3 L hour(-1) ), metabolic clearance (34.6 L hour(-1) ), volume of distribution of compartment 1 (216.0 L) and volume of distribution of compartment 2 (384.0 L). Population parameter estimates of EDDP were elimination clearance (121.0 L hour(-1) ), volume of distribution of compartment 3 (1.08 L) and volume of distribution of compartment 4 (499.5 L). The total clearance and total volume of distribution of methadone and EDDP were 51.9 L hour(-1) , 121.0 L hour (-1) , 600.0 L and 500.6 L, respectively. The methadone terminal elimination half-life was 8.19 hours. No adverse effects were observed after methadone administration. Following intramuscular injection, methadone was characterized by a large total volume of distribution, high systemic clearance and intermediate terminal half-life in sika deer. © 2014 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia.

  1. Intramuscular injection of human umbilical cord-derived mesenchymal stem cells improves cardiac function in dilated cardiomyopathy rats.

    Science.gov (United States)

    Mao, Chenggang; Hou, Xu; Wang, Benzhen; Chi, Jingwei; Jiang, Yanjie; Zhang, Caining; Li, Zipu

    2017-01-28

    Stem cells provide a promising candidate for the treatment of the fatal pediatric dilated cardiomyopathy (DCM). This study aimed to investigate the effects of intramuscular injection of human umbilical cord-derived mesenchymal stem cells (hUCMSCs) on the cardiac function of a DCM rat model. A DCM model was established by intraperitoneal injections of doxorubicin in Sprague-Dawley rats. hUCMSCs at different concentrations or cultured medium were injected via limb skeletal muscles, with blank medium injected as the control. The rats were monitored for 4 weeks, meanwhile BNP, cTNI, VEGF, HGF, GM-CSF, and LIF in the peripheral blood were examined by ELISA, and cardiac function was monitored by echocardiography (Echo-CG). Finally, the expression of IGF-1, HGF, and VEGF in the myocardium was examined by histoimmunochemistry and real-time PCR, and the ultrastructure of the myocardium was examined by electron microscopy. Injection of hUCMSCs markedly improved cardiac function in the DCM rats by significantly elevating left ventricular ejection fraction (LVEF) and left ventricular fraction shortening (LVFS). The BNP and cTNI levels in the peripheral blood were reduced by hUCMSCs, while HGF, LIF, GM-CSF, and VEGF were increased by hUCMSCs. Expression of IGF-1, HGF, and VEGF in the myocardium from the DCM rats was significantly increased by hUCMSC injection. Furthermore, hUCMSCs protected the ultrastructure of cardiomyocytes by attenuating mitochondrial swelling and maintaining sarcolemma integrity. Intramuscular injection of UCMSCs can improve DCM-induced cardiac function impairment and protect the myocardium. These effects may be mediated by regulation of relevant cytokines in serum and the myocardium.

  2. Oral and intramuscular application of cyanogenic glycoside amygdalin did not induce changes in haematological profile of male rabbits

    Directory of Open Access Journals (Sweden)

    Katarína Zbyňovská

    2017-01-01

    Full Text Available Amygdalin is a cyanogenic glycoside initially obtained from the seeds of bitter almonds. It is composed of one molecule of benzaldehyde, two molecules of glucose and one molecule of hydrocyanic acid. Various ways of amygdalin application play a different role in recipient organism. Intravenous infusion of amygdalin produced neither cyanidemia nor signs of toxicity, but oral administration resulted in significant blood cyanide levels. The present in vivo study was designed to reveal whether amygdalin is able to cause changes in the haematological profile and thus alter the physiological functions, using rabbits as a biological model. Adult male rabbits (n = 20 were randomly divided into five groups: the control group without any amygdalin administration, two experimental groups received a daily intramuscular injection of amygdalin at a dose 0.6 and 3.0 mg.kg-1 b.w. and other two groups were fed by crushed apricot seeds at dose 60 and 300 mg. kg-1 b.w., mixed with commercial feed over the period of 14 days. After two weeks, haematological parameters in whole blood were analysed (WBC - total white blood cell count, LYM - lymphocytes count, MID - medium size cell count, GRA - granulocytes count, RBC - red blood cell count, HGB - haemoglobin, HCT - haematocrit, MCV - mean corpuscular volume, MCH - mean corpuscular hemoglobin, MCHC - mean corpuscular hemoglobin concentration, RDWc - red cell distribution width, PLT - platelet count, PCT - platelet percentage, MPV - mean platelet volume, PDWc - platelet distribution width using haematology analyser Abacus junior VET. Our findings indicate that intramuscular and oral application of amygdalin for two weeks did not significantly affect the haematology parameters in experimental animals. In this study, no obvious beneficial or negative effects of amygdalin administration on the blood of male rabbits were observed.

  3. Distinctive genes determine different intramuscular fat and muscle fiber ratios of the longissimus dorsi muscles in Jinhua and landrace pigs.

    Directory of Open Access Journals (Sweden)

    Ting Wu

    Full Text Available Meat quality is determined by properties such as carcass color, tenderness and drip loss. These properties are closely associated with meat composition, which includes the types of muscle fiber and content of intramuscular fat (IMF. Muscle fibers are the main contributors to meat mass, while IMF not only contributes to the sensory properties but also to the plethora of physical, chemical and technological properties of meat. However, little is known about the molecular mechanisms that determine meat composition in different pig breeds. In this report we show that Jinhua pigs, a Chinese breed, contains much higher levels of IMF than do Landrace pigs, a Danish breed. We analyzed global gene expression profiles in the longissimus dorsi muscles in Jinhua and Landrace breeds at the ages of 30, 90 and 150 days. Cross-comparison analysis revealed that genes that regulate fatty acid biosynthesis (e.g., fatty acid synthase and stearoyl-CoA desaturase are expressed at higher levels in Jinhua pigs whereas those that regulate myogenesis (e.g., myogenic factor 6 and forkhead box O1 are expressed at higher levels in Landrace pigs. Among those genes which are highly expressed in Jinhua pigs at 90 days (d90, we identified a novel gene porcine FLJ36031 (pFLJ, which functions as a positive regulator of fat deposition in cultured intramuscular adipocytes. In summary, our data showed that the up-regulation of fatty acid biosynthesis regulatory genes such as pFLJ and myogenesis inhibitory genes such as myostatin in the longissimus dorsi muscles of Jinhua pigs could explain why this local breed produces meat with high levels of IMF.

  4. Distinctive genes determine different intramuscular fat and muscle fiber ratios of the longissimus dorsi muscles in Jinhua and landrace pigs.

    Science.gov (United States)

    Wu, Ting; Zhang, Zhenhai; Yuan, Zhangqin; Lo, Li Jan; Chen, Jun; Wang, Yizhen; Peng, Jinrong

    2013-01-01

    Meat quality is determined by properties such as carcass color, tenderness and drip loss. These properties are closely associated with meat composition, which includes the types of muscle fiber and content of intramuscular fat (IMF). Muscle fibers are the main contributors to meat mass, while IMF not only contributes to the sensory properties but also to the plethora of physical, chemical and technological properties of meat. However, little is known about the molecular mechanisms that determine meat composition in different pig breeds. In this report we show that Jinhua pigs, a Chinese breed, contains much higher levels of IMF than do Landrace pigs, a Danish breed. We analyzed global gene expression profiles in the longissimus dorsi muscles in Jinhua and Landrace breeds at the ages of 30, 90 and 150 days. Cross-comparison analysis revealed that genes that regulate fatty acid biosynthesis (e.g., fatty acid synthase and stearoyl-CoA desaturase) are expressed at higher levels in Jinhua pigs whereas those that regulate myogenesis (e.g., myogenic factor 6 and forkhead box O1) are expressed at higher levels in Landrace pigs. Among those genes which are highly expressed in Jinhua pigs at 90 days (d90), we identified a novel gene porcine FLJ36031 (pFLJ), which functions as a positive regulator of fat deposition in cultured intramuscular adipocytes. In summary, our data showed that the up-regulation of fatty acid biosynthesis regulatory genes such as pFLJ and myogenesis inhibitory genes such as myostatin in the longissimus dorsi muscles of Jinhua pigs could explain why this local breed produces meat with high levels of IMF.

  5. Product-service systems em laboratório de análises clínicas: um estudo de caso

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    Veridiana Rotondaro Pereira

    2016-06-01

    Full Text Available Resumo Cada vez mais as empresas oferecem soluções completas a seus clientes, com produtos e serviços. Essa mudança na composição do portfólio das organizações vem ocorrendo por uma série de razões, sejam relacionadas às questões estratégicas, motivadas por demandas do cliente, ou ainda por tendências que visam menores impactos ambientais. Este artigo visa contribuir com a literatura existente, adicionando a perspectiva do cliente neste cenário, por meio de um estudo de caso nos laboratórios de um dos principais hospitais da América Latina. Investigou-se a aquisição de equipamentos de análises clínicas, e os resultados mostram uma trajetória evolutiva de implementação do PSS durante as últimas décadas. Como cliente, este laboratório passou por três fases de evolução: primeiro como comprador de equipamentos, depois, numa segunda etapa, como os equipamentos não eram mais de propriedade do laboratório, passaram para contratos de leasing, e no terceiro estágio, para a aquisição de um contrato integrado de PSS, orientado a resultado. Nesta última fase, o laboratório observou vantagens importantes relacionadas tanto ao uso dos produtos quanto ao atendimento a demandas internas. Estas mudanças no processo de compra trouxeram importantes ganhos para o laboratório, como um sistema operacional seguro, a divisão dos riscos com o provedor da solução, suporte técnico especializado.

  6. Uma exposição acidental aos raios X de um difratômetro

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    Valverde N.J. de L.

    2000-01-01

    Full Text Available As mãos de três trabalhadores foram irradiadas acidentalmente numa indústria em Camaçari, Estado da Bahia, Brasil. O diagnóstico clínico de radiodermite aguda foi possível, antes mesmo da confirmação dosimétrica da ocorrência, em virtude das manifestações cutâneas exibidas, precedidas por um eritema, e também pelas histórias ocupacionais. As avaliações das doses recebidas pelos acidentados, usando-se restituições com dosímetros termoluminescentes, tiveram boa correlação com as doses estimadas em função das manifestações clínicas. A causa imediata do acidente foi a má manutenção do equipamento que levou a sua janela posterior a ficar permanentemente aberta, porém foram fatores contributórios importantes a falta de informação dos empregados sobre os possíveis efeitos biológicos das radiações ionizantes e o não seguimento dos procedimentos operacionais corretos. A descrição deste acidente é importante, face ao grande número de difratômetros existentes em laboratórios, universidades, centros de pesquisa e indústrias. Tais aparelhos são considerados "virtualmente isentos de risco ocupacional", o que não é verdadeiro, como comprova a ocorrência que descrevemos. A evolução médica dos pacientes tem sido satisfatória, especialmente em virtude da baixa energia do feixe de raios X do difratômetro e, em conseqüência, da sua pequena penetração tissular.

  7. Comparison of the Immunogenicity of Various Booster Doses of Inactivated Polio Vaccine Delivered Intradermally Versus Intramuscularly to HIV-Infected Adults.

    Science.gov (United States)

    Troy, Stephanie B; Kouiavskaia, Diana; Siik, Julia; Kochba, Efrat; Beydoun, Hind; Mirochnitchenko, Olga; Levin, Yotam; Khardori, Nancy; Chumakov, Konstantin; Maldonado, Yvonne

    2015-06-15

    Inactivated polio vaccine (IPV) is necessary for global polio eradication because oral polio vaccine can rarely cause poliomyelitis as it mutates and may fail to provide adequate immunity in immunocompromised populations. However, IPV is unaffordable for many developing countries. Intradermal IPV shows promise as a means to decrease the effective dose and cost of IPV, but prior studies, all using 20% of the standard dose used in intramuscular IPV, resulted in inferior antibody titers. We randomly assigned 231 adults with well-controlled human immunodeficiency virus infection at a ratio of 2:2:2:1 to receive 40% of the standard dose of IPV intradermally, 20% of the standard dose intradermally, the full standard dose intramuscularly, or 40% of the standard dose intramuscularly. Intradermal vaccination was done using the NanoPass MicronJet600 microneedle device. Baseline immunity was 87%, 90%, and 66% against poliovirus serotypes 1, 2, and 3, respectively. After vaccination, antibody titers increased a median of 64-fold. Vaccine response to 40% of the standard dose administered intradermally was comparable to that of the standard dose of IPV administered intramuscularly and resulted in higher (although not significantly) antibody titers. Intradermal administration had higher a incidence of local side effects (redness and itching) but a similar incidence of systemic side effects and was preferred by study participants over intramuscular administration. A 60% reduction in the standard IPV dose without reduction in antibody titers is possible through intradermal administration. © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  8. Neuromuscular partitioning in the extensor carpi radialis longus and brevis based on intramuscular nerve distribution patterns: A three-dimensional modeling study.

    Science.gov (United States)

    Ravichandiran, Mayoorendra; Ravichandiran, Nisanthini; Ravichandiran, Kajeandra; McKee, Nancy H; Richardson, Denyse; Oliver, Michele; Agur, Anne M

    2012-04-01

    Differential activation of specific regions within a skeletal muscle has been linked to the presence of neuromuscular compartments. However, few studies have investigated the extra- or intramuscular innervation throughout the muscle volume of extensor carpi radialis longus (ECRL) and brevis (ECRB). The aim of this study was to determine the presence of neuromuscular partitions in ECRL and ECRB based on the extra- and intramuscular innervation using three-dimensional modeling. The extra- and intramuscular nerve distribution was digitized and reconstructed in 3D in all the muscle volumes using Autodesk Maya in seven formalin embalmed cadaveric specimens (mean age, 75.7 ± 15.2 years). The intramuscular nerve distribution was modeled in all the muscle volumes. ECRL was found to have two neuromuscular compartments, superficial and deep. One branch from the radial nerve proper was found to innervate ECRL. This branch was divided into anterior and posterior branches to the superficial and deep compartments, respectively. Five innervation patterns were identified in ECRB with partitioning of the muscle belly into two, three, or four compartments, in a proximal to distal direction depending on the number of nerve branches entering the muscle belly. The ECRL and ECRB both demonstrated neuromuscular compartmentalization based on intramuscular innervation. According to the partitioning hypothesis, a muscle may be differentially activated depending on the required function of the muscle, thus allowing multifunctional muscles to contribute to a variety of movements. Therefore, the increased number of neuromuscular partitions in ECRB when compared with ECRL could be due to the need for more differential recruitment in the ECRB depending on force requirements. Copyright © 2011 Wiley Periodicals, Inc.

  9. Se não há Um...: a relação do outro com o outro na Sétima Tese da Segunda hipótese do Parmênides de Platão

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    Gabriele Cornelli

    2016-12-01

    Full Text Available O presente ensaio tem como objetivo examinar o problema colocado na Sétima Tese da Segunda Hipótese do Parmênides de Platão (164b-165E. A citada hipótese centra-se na relação dos outros com o outro, voltando assim para a Terceira Tese, mas, desta vez, sem o apoio do Um para impedir a fragmentação. Assim, toda a percepção da realidade sofre um processo de deriva, descrito por Parmênides como “um sonho durante o sono”, no qual cada um dos outros “de Um que parecia se revela multíplice, de pequeníssimo um todo enorme” (164d. O sonho, no entanto, apresenta características muito precisas destes conjuntos: entre elas, o fato de “ter o número” (164d e “aparecer no seu interior o par e o ímpar” (164e. O “sonho numérico” de Parmênides pode ser uma importante chave de leitura para compreender a consistência histórico-teórica da Sétima Tese, especialmente quando visto à luz do debate ontológico e matemático que ocupa o Quinto Século, antes de Platão.

  10. QUALIDADE DE VIDA NO TRABALHO (QVT: UM ESTUDO COM PROFESSORES DOS INSTITUTOS FEDERAIS

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    Rodrigo Ribeiro de Oliveira

    2015-12-01

    Full Text Available No cenário atual em que há exigências contínuas de evolução do conhecimento e de avanços tecnológicos, a educação tecnológica é um assunto que merece destaque, pois é através dela que uma grande parcela dos trabalhadores é formada para atuar no mercado de trabalho cada vez mais qualificado e competitivo. Um dos projetos estratégicos mais importantes na área de ensino no país é o dos Institutos Federais que contam com 562 campi em todo país. Houve um crescimento significativo do quadro funcional: no ano de 2002 contava com 8.999 professores, atualmente conta com 37.021 (2015. Isso mostra um crescimento de 411,39%. Nesse contexto, o objetivo deste trabalho foi analisar o grau de satisfação dos professores dos Institutos Federais em relação à Qualidade de Vida no Trabalho, diante dos impactos da expansão da rede no Brasil. A pesquisa foi realizada com professores que participaram do II Fórum Mundial de Educação Profissional e Tecnológica, realizado em Florianópolis em 2012. Esta pesquisa caracteriza-se como quantitativa, exploratória, descritiva e avaliação (survey. Com relação ao instrumento, foi utilizado o Protocolo Biopsicossocial e organizacional - BPSO-96, de Limongi-França. Foram respondidos 43 questionários. Entre os cinco domínios avaliados, constatou-se que o domínio social foi o que apresentou o menor índice de satisfação (3,193, enquanto que o domínio psicológico foi o que apresentou maior satisfação (6,819. Destaca-se que a variável que apresentou a maior média na pesquisa foi a relação professor-aluno (8,233. Embora os resultados não possam ser generalizados para o expressivo universo de professores do Ensino Técnico dos Institutos Federais, os achados deste estudo demonstram a necessidade de alinhamento quanto à política de gestão de benefícios e apoio familiar e comunitário no grupo pesquisado, revelando a qualidade da relação ensino-aprendizado neste cenário.

  11. Um estudo exploratório sobre colaboração logística em um grande varejo supermercadista An exploratory study of collaborative logistics in a large supermarket chain

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    José Geraldo Vidal Vieira

    2010-03-01

    Full Text Available Esta pesquisa tem por objetivo discutir os elementos de colaboração logística importantes para a construção de um melhor relacionamento entre o varejista e seus fornecedores. Esses elementos foram identificados a partir da literatura e observados em um estudo de caso em uma grande rede de varejo supermercadista. As teorias relacionadas à pesquisa são referentes à natureza da colaboração, ao desempenho logístico e à economia dos custos de transação. Dentre os elementos usualmente mais citados para o processo de colaboração, como confiança, reciprocidade, compartilhamento de informações, interação entre as áreas funcionais, objetivos e metas conjuntas, e integração interpessoal, os resultados sugerem que este último elemento é o mais importante no processo de colaboração logística.This research discusses the logistic cooperation elements important for building a better relationship between a retailer and its suppliers. These elements were identified in the literature and observed in a case study based on a large supermarket chain. The research refers to the theories concerning the nature of collaboration, the logistic performance and the economy of transaction costs. Among the factors commonly cited in the collaboration process, such as trust, reciprocity, information sharing, interaction between functional areas, joint objectives and targets, and interpersonal integration, the results suggest that the latter particularly is the most important in the collaborative process.

  12. Um personagem da memória campo-bonense?: o emblemático pastor Klingelhoeffer, soldado Farroupilha

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    Souza, José Edimar de

    2011-01-01

    Full Text Available A presente pesquisa analisa os motivos que teriam levado um “cura de almas” a empunhar armas contra o Império. Friedrich Christian Klinglhoeffer, popularmente conhecido como Pastor Farrapo, com seu envolvimento na Revolução Farroupilha transforma-se em pastor mártir da causa republicana no Rio Grande do Sul. Na busca das justificativas deste fato avalia-se a situação política da Europa (Alemanha no século XIX, bem como o Brasil e o Rio Grande do Sul à época da imigração de Klingelhoeffer. Neste contexto, se desenvolve a trajetória e importante participação de Klingellhoeffer na Revolução Farroupilha e, principalmente, no desenvolvimento de Campo Bom e para o progresso do Vale dos Sinos

  13. Viagens em Troia com Freire:a tecnologia como um agente de emancipação

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    Paulo Blikstein

    Full Text Available Resumo A rápida penetração de novas tecnologias na escola constitui uma oportunidade para a disseminação da filosofia de dois importantes teóricos da educação: Seymour Papert e Paulo Freire. As tecnologias digitais possibilitam formas diversas e inovadoras de trabalhar, expressar e construir. Essa adaptabilidade camaleônica da mídia computacional promove diversidade epistemológica (TURKLE; PAPERT, 1991, criando um ambiente no qual os alunos, na sua própria voz, podem concretizar suas ideias e projetos com motivação e empenho. Este artigo descreve uma implementação conduzida em uma escola pública brasileira e gera uma série de princípios de design de ambientes Papert/Freireanos, analisando o empenho intelectual e emocional dos estudantes, suas trajetória de aprendizado e a complexidade de seus projetos, que variaram de robôs controlados por computador a filmes de ficção científica. O artigo discute um modelo de implementação com quatro componentes: primeiro, identificar um tema gerador relevante para a comunidade; segundo, partir da cultura e da experiência tecnológica da comunidade como base para a introdução de novas tecnologias; terceiro, deliberadamente usar uma abordagem de mídia mista, em que alta e baixa tecnologia coexistem; por fim, deslocar certos protocolos sociais e comportamentais considerados normais nas escolas, mesmo aqueles aparentemente irrelevantes para o ensino e a aprendizagem. Conclui-se que tal utilização de tecnologias expressivas pode ser um poderoso agente de emancipação à Paulo Freire e, em especial, em comunidades economicamente carentes.

  14. Um mapeamento descritivo dos modelos de gestão de redes de correspondentes bancários no Brasil

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    Martin Jayo

    2013-09-01

    Full Text Available Apesar dos diversos estudos que se desenvolveram nos últimos anos enfocando o crescimento dos chamados correspondentes bancários (CBs como canal de distribuição de serviços financeiros à população de baixa renda no Brasil, existe uma importante lacuna nessa literatura, relacionada à compreensão das diferentes formas pelas quais redes de CBs podem ser montadas e geridas. No presente artigo teve-se por objetivo construir um mapeamento das diferentes configurações de negócios - ou modelos de gestão de redes de CBs - hoje praticadas na utilização do canal de CBs pelos bancos brasileiros. Para tanto, adotou-se um método taxonômico, que permitiu distinguir a existência de seis diferentes modelos de gestão de redes de CBs praticados pelos bancos na gestão do canal, os quais foram, por sua vez, agrupados em três classes, de acordo com o grau de delegação de atividades a gestores de rede terceirizados. O resultado do trabalho é um mapeamento inédito das diferentes configurações de negócios praticadas na operação do canal de CBs no Brasil. A relevância da contribuição deriva da escassez de referências ao tópico em estudos anteriores, bem como da importância adquirida em anos recentes pelo canal de CBs como um dos principais canais de distribuição de serviços bancários à população de baixa renda.

  15. RECICLAGEM DE PRECIPITAÇÃO NA AMAZÔNIA: UM ESTUDO DE REVISÃO

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    Vinícius Machado Rocha

    2015-03-01

    Full Text Available Este artigo traz uma perspectiva histórica da evolução do conhecimento sobre a reciclagem de precipitação e fornece uma visão crítica do estado da arte atual. São retratadas as principais fontes de umidade para a precipitação na Amazônia e o transporte de vapor d'água sobre a América do Sul. A quantificação do mecanismo de reciclagem é um indicador da importância dos processos de superfície e do clima no ciclo hidrológico, assim como da sensibilidade climática relacionada às alterações nesses processos. Os aspectos climatológicos da reciclagem na América do Sul mostram que a contribuição advectiva é mais importante para a precipitação sobre a Amazônia e o Nordeste do Brasil, ao passo que na região Centro-Sul a contribuição local tem importante papel na precipitação. Estima-se que a reciclagem de precipitação na Amazônia é da ordem de 20-35%. A advecção de umidade domina o fornecimento de vapor d'água em grande parte da região amazônica, entretanto, o papel da evapotranspiração local na reciclagem é mais importante no setor sul da bacia. Embora os estudos sobre reciclagem tenham produzido novos conhecimentos acerca da interação entre os processos de superfície e o ciclo hidrológico, os efeitos das mudanças climáticas globais nesse mecanismo ainda não estão completamente compreendidos.

  16. Como antecipar os efeitos de uma tecnologia? Um Modelo Exploratório Inspirado na Nova Ciência de McLuhan e Aplicado ao Facebook

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    Vinícius Andrade Pereira

    2015-12-01

    Full Text Available O artigo tem como objetivo principal identificar os principais efeitos dos sites de redes sociais (SRS na cultura contemporânea, tendo como objeto específico o Facebook. Como referência teórica e metodológica adota-se uma proposição exploratória fortemente inspirada em uma “Nova Ciência”, tal como aventada por McLuhan. Isso implica a Lei dos Meios, sintetizada nas Tétrades. Como resultados o estudo propõe um conjunto de efeitos do Facebook na cultura contemporânea, que já podem ser identificados e mapeados e que se constituem como novos pontos e questões para futuras pesquisas. Ainda, apresenta um método de pesquisa que propõe o diálogo com disciplinas correlatas ao campo da comunicação, assim como uma metodologia flexível, capaz de lidar com descrições em profundidade de um objeto, ao mesmo tempo que acolher acasos e desvios de um procedimento científico ortodoxo, tal como preconizado por Feyerabend. Por fim, o estudo recupera uma parte importante da obra de McLuhan, ainda pouco explorada nos estudos comunacionais no Brasil.

  17. Estimativa do intervalo pós-morte em um canino (Canis lupus familiaris Linnaeus 1758 pela entomologia forense em Cabedelo-PB, Brasil: relato de caso

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    G. Martins

    2013-08-01

    Full Text Available O intervalo pós-morte (IPM é um instrumento importante de diagnóstico relacionado à prática forense. O uso de insetos tem sido relatado como um modo eficiente para estimá-lo, quando o cadáver encontra-se em estágio avançado de decomposição. Objetivou-se com este trabalho estimar o IPM com base em evidências entomológicas em um canino. Foram coletadas larvas de moscas no cadáver e encaminhadas ao laboratório de entomologia, onde foram criadas e eclodiram adultos da espécie Chrysomya albiceps (Wiedemann, 1819. Somando-se os dados abióticos de temperatura e umidade relativa do local de coleta e do local de criação, estimou-se um IPM mínimo de 3,34 dias do momento da postura dos ovos pelas moscas até a coleta das larvas. Com base nos resultados obtidos, conclui-se que a entomologia forense, como ferramenta para estimativa do IPM, mostrou-se eficaz e determinante na elucidação do caso em questão.

  18. E-278 - ORDENS RÉGIAS 1681-1809. Um códice do Arquivo da Cúria Metropolitana do Rio de Janeiro

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    Beatriz Catão Cruz Santos

    Full Text Available Este trabalho é um instrumento de pesquisa que apresenta o livro ou códice E-278 - Ordens Régias 1681-1809, localizado no Arquivo da Cúria Metropolitana do Rio de Janeiro. Contém um índice de ordens, alvarás e cartas reunidas sob a rubrica "ordens régias", expedidas em nome do soberano e transmitidas ao bispado do Rio de Janeiro entre 1681 e 1809. Acompanha o índice uma introdução sobre a documentação e um panorama dos assuntos tratados. O trabalho é um dos resultados da pesquisa Irmandades, Capelas e Rituais no Rio de Janeiro do século XVIII, desenvolvida na Universidade Federal do Rio de Janeiro. A publicação do referido códice, entre três que a pesquisa selecionou, é importante para a história do Rio de Janeiro no Antigo Regime e sua inserção no império português.

  19. Monocitose é um marcador de risco independente para a doença arterial coronariana

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    Afiune Neto Abrahão

    2006-01-01

    Full Text Available OBJETIVOS: Inflamação e ativação das células do sistema imunológico têm participação importante na patogênese da aterosclerose. Este estudo analisa o leucograma que incluiu neutrófilos, eosinófilos, linfócitos, monócitos e basófilos dos pacientes com doença arterial coronariana (DAC crônica e no infarto agudo do miocárdio (IAM. MÉTODOS: Analisamos o leucograma de 232 pacientes não-diabéticos, com idade entre 15 e 88 anos. A DAC estava presente em 142 pacientes (57 com DAC estável e 85 com IAM, diagnosticada angiograficamente, comparada a 90 indivíduos-controle. Os grupos controle e DAC foram comparáveis para a idade, índice de massa corpórea, antecedentes familiares, tabagismo, hipertensão, HDL e LDL (todas variáveis com p > 0,25. RESULTADOS: A análise univariada mostrou maior prevalência de leucocitose na DAC, sendo maior nos pacientes com IAM quando comparados com a DAC estável. O mesmo comportamento foi observado para os monócitos. Porém, a distribuição foi semelhante para as demais células do hemograma. A análise multivariada pelo método da regressão logística, utilizando-se os modelos stepwise (todas variáveis e backward (p < 0,25, mostrou que a monocitose foi variável independente para DAC e para o IAM. CONCLUSÃO: O número de monócitos, um dos mais importantes componentes do processo inflamatório na placa aterosclerótica, foi um marcador de risco independente para a DAC e para o IAM.

  20. Os programas de emagrecimento na Internet: um estudo exploratório Diet programs on the Internet: brief notes

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    Ligia Amparo da Silva Santos

    2007-01-01

    Full Text Available Este texto é parte de um estudo sobre estratégias educativas utilizadas pelos programas de emagrecimento oferecidos via Internet e tem como objetivo descrever e analisar alguns elementos estruturantes desses sites. Observou-se que os mesmos utilizam estratégias que se aproximam mais da realidade cotidiana dos participantes, e que aspectos psicológicos e motivacionais são considerados importantes. Além disso, há uma tentativa de criar estratégias educacionais que transitem da concepção do "fazer dieta" para o conceito de reeducação alimentar concebida como "o comer de tudo, sem passar fome". Tal fato revela uma aliança entre as ciências da nutrição e a gastronomia, que representa um elo importante nas tentativas do resgate do prazer em comer. Destaca-se a importância de estudar tais estratégias, uma vez que o emagrecimento tem sido uma meta desejada por grande parte da população, seja com objetivo de ampliar a qualidade da saúde, seja com fins estéticos.This paper aims to describe and analyze some elements of diet programs offered on the Internet. The study observed that strategies used by the programs are familiar to people, and that psychological and motivational aspects are important. Therefore, there is an attempt to create educational strategies ranging from the concept of "doing diet" to "nutritional re-education". The latter is understood as "to eat everything, without starving". This fact unveils an alliance between the nutritional sciences and gastronomy, which greatly helps recovering the pleasure of eating. The text points out the importance of studying such strategies, mainly because losing weight is the objective of the largest part of the population, either for improving health or for aesthetical purposes.

  1. EMPREENDEDORISMO E VALORES HUMANOS: UM ESTUDO CONCEITUAL

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    Luciano Vignochi

    2013-09-01

    Full Text Available O objetivo principal deste artigo foi identificar conceitos de valores humanos em publicações científicas sobre empreendedorismo. Não há um único conceito de valores humanos, gerando diversas abordagens e aplicações do termo em estudos sobre empreendedorismo. Para identificar diferenças conceituais e aplicações práticas, optou-se por realizar uma análise de conteúdo em um portfólio de artigos selecionados em bases de dados. O principal critério de seleção das publicações foi aderência ao tema. Os resultados mostram que valores podem ser definidos como: critérios de julgamento da realidade; aspectos abstratos, cognitivos e afetivos ou características determinantes da personalidade e do comportamento de empreendedores. Valores influenciam a sobrevivência do indivíduo, o crescimento do empreendimento e podem nivelar a congruência do empreendedor e seu propósito de empreendimento com os critérios de convivência social. Ainda foram discriminados resultados de estudos aplicados com vistas a destacar evidências de contribuições práticas de pesquisas sobre valores humanos em empreendedorismo. Futuras investigações para aprofundar e replicar as análises realizadas neste estudo podem contribuir com a formação de empreendedores, a realização de diagnóstico empresarial e com avanços para a consolidação um modelo de desenvolvimento de empresas baseado em valores humanos.

  2. É POSSÍVEL UM SUJEITO ECLESIAL?

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    Mario Miranda

    2011-01-01

    Full Text Available A afirmação presente no Documento de Aparecida de que o laicato é sujeito eclesial nos levou a examinar os pressupostos para que ele o seja de fato. Assim, depois de descrever em breves traços a Igreja que herdamos do passado, abordamos a necessidade de se criar uma nova mentalidade no laicato, então caracterizada no passado pela passividade. Entretanto, constatamos que a esta nova mentalidade exige também mudança na configuração eclesial para que possa fazer emergir um laicato adulto e ativo, já que existe uma interação entre ambas. No final, mencionamos ainda as exigências de cunho espiritual, como a liberdade interior e o amor à Igreja para um juízo objetivo e um comportamento correspondente por parte do indivíduo na comunidade eclesial. ABSTRACT: The present affirmation in the Document of Aparecida that the layperson is an ecclesiastical subject led us to examine the suppositions supporting that he is in fact. Thus, after describing in brief traces the Church that we inherit from the past, we approach the necessity of creating a new mentality in the laity, up until now characterized in the past by passivity. However, we report that this new mentality demands change in the ecclesiastical configuration so that it can allow the emergence of an adult and active laity, since an interaction between both already exists. In the end, we mention the requirements of a spiritual nature, as the interior freedom and the love of the Church for an objective judgment and a corresponding behavior on the part of the individual in the ecclesiastical community.

  3. Mestre ou aprendiz: faces de um narrador

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    Marcelo Antonio Ribas Hauck

    2009-12-01

    Full Text Available Narrar é, segundo Benjamim, uma forma de intercambiar experiências, e se direcionarmos nosso olhar para o sujeito dessa narrativa, o teremos em duas funções: ora como narrador mestre, ora como narrador aprendiz. Contar estórias é um instrumento útil para evitar o esquecimento e para provocar uma abertura de espaço para a criação. O presente artigo apresenta uma das inúmeras possíveis leituras sobre as estratégias utilizadas por Mia Couto, em Terra sonâmbula, na criação de sujeitos que narram, que contam estórias. Uma busca por esses narradores em trânsito, narradores flutuantes ou nômades. Sujeitos em constante ir e vir, transitando e destransitando entre mundos aparentemente paradoxais, mas que se encontram separados por uma tênue linha, que, a qualquer momento, pode fazer com que mestre e aprendiz troquem de campo e função, ou até mesmo exerçam ambas. Os dois aprendem estórias novas e contam estórias antigas em um ir-evir espaço-temporal. O comportamento desses narradores é marcado por viagens e mutações ininterruptas. Constituinte de uma literatura atravessada por elementos insólitos, em um trabalho minucioso com a linguagem e em constante diálogo com a tradição moçambicana, esse comportamento tornase referencial para a compreensão da história política e cultural do país.Palavras-chave: Narrador; Benjamin; Hibridismo; Oratura; Identidade.

  4. A qualidade do ambiente de loja no varejo de supermercados: um estudo de caso em uma rede de supermercados em Araguaína/TO

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    Rumeninng Abrantes Santos

    2013-12-01

    Full Text Available O objeto principal deste estudo é verificar quais as características que levam os comportamentos motivacionais de seleção de lojas e formatos de varejo de alimentos por parte do consumidor de baixa renda da cidade de Araguaína Tocantins. Neste estudo observou-se que as técnicas qualitativas de investigação apontam características do consumidor de baixa renda bem como o comportamento das empresas varejistas de alimentos quanto ao posicionando frente a esse consumidor. Os pontos principais deste estudo levam em conta de que no ato da compra a loja pode proporcionar ao consumidor uma experiência extremamente agradável, desde que se crie todo um ambiente agradável que passe uma boa imagem e proporcione certo calor humano, de prazer e aceitação. Por isso, o atendimento e o trabalho de visual merchandising são extremamente importantes na construção de valor. Os resultados revelam que o preço dos produtos nem sempre é importante para os consumidores, o que é comprovado pela preferência dos consumidores na região de estudo pelo supermercado que pratica os maiores preços, mas que com eficiência desenvolve um trabalho exaustivo e sinérgico nos outros produtos do mix de marketing.

  5. Hemangioma de úvula: relato de um caso

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    G. Sobrinho Fernando P.

    2003-01-01

    Full Text Available O hemangioma é o mais comum tumor de origem vascular, benigno, freqüentemente diagnosticado em crianças, e com predileção pela cabeça e pescoço, mas que raramente tem origem na úvula. Neste órgão, apresenta risco de traumatismo local e sangramento. Este artigo relato um caso de hemangioma de úvula num adulto jovem com disfagia orofaríngea progressiva e sensação de corpo estranho na garganta, tratado com sucesso por ressecção cirúrgica do tumor com bisturi de radiofreqüência.

  6. Estou Satisfeito: Um Estudo sobre a Lealdade do Consumidor em Restaurantes Empregando a Escala Dineserv

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    Carlos Alberto Alves

    2017-08-01

    Full Text Available O propósito deste trabalho é investigar a relação entre a qualidade de serviços e a lealdade do consumidor mediada pela satisfação, por meio de um estudo empírico realizado com frequentadores de restaurantes na cidade de São Paulo. Por meio de uma extensiva revisão bibliográfica, duas hipóteses centrais foram formuladas: a a qualidade de serviços percebida possui relação direta e significante com a lealdade e b a satisfação é um fator mediador, contribuindo com a relação qualidade de serviço percebida e lealdade do consumidor.  Foi realizada uma pesquisa tipo survey com 444 consumidores que frequentam restaurantes para jantar na cidade de São Paulo, e utilizada a Modelagem de Equação Estrutural, para avaliar as relações entre caminhos e testes de hipóteses. Os resultados apontam para uma relação positiva e significante entre a qualidade percebida em serviços e a lealdade do consumidor e, da mesma forma, foi encontrado que a satisfação possui papel de mediação na relação. Como contribuição gerencial, os resultados deste estudo dão algumas importantes direções aos gestores de restaurantes na formulação de uma estratégia para fornecer uma qualidade de serviço superior aos seus clientes e consumidores. Este estudo se justifica tanto teoricamente como gerencialmente, pois, no Brasil, poucos trabalhos publicados consideram a relação entre a qualidade percebida de serviços e a lealdade do consumidor, mediada pela satisfação no setor de hospitalidade.

  7. Leitura na escola: um barco à deriva?

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    Teixeira, Marlene

    2008-01-01

    Full Text Available Este artigo busca, na teoria da enunciação de É. Benveniste, elementos para repensar o trabalho com a leitura na escola. Considera que, na discussão das noções gêmeas de forma e sentido, o autor formula uma concepção de significado que, de um lado, pode deter a interpretação à deriva, implicada na visão de leitura centrada no leitor, e, de outro lado, possibilita que se transcenda a idéia de que é pela decifração mdo código que se dá o processo de construção do significado. Conclui que, no processo de leitura, é sempre de um trabalho com a língua que se trata, trabalho que se renova a cada ato de aproximação do aluno com o texto, porque a língua é submetida ao ato de enunciação

  8. UM MODELO INFORMACIONAL PARA EMPRESAS MULTIPLANTA

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    Rogério Matos Dias

    2006-09-01

    Full Text Available Este estudo objetiva conceber, testar e demonstrar a aplicabilidade de um modelo informacional que possibilite a gestão integrada das operações da cadeia de suprimentos para firmas geograficamente dispersas – também denominadas empresas multiplanta. Para tanto, foram aplicados os métodos de pesquisa de caso e pesquisa-ação em uma empresa representativa do setor mínero-metalúrgico em âmbito mundial, a Rio Doce Manganês S.A., subsidiária da Cia. Vale do Rio Doce. A pesquisa pretende demonstrar que o modelo de sistema informacional proposto, por meio da automatização dos processos transacionais e gerenciais, é capaz de prover recursos de planejamento e controle nos níveis operacional, tático e estratégico, devido a sua capacidade de incrementar velocidade e qualidade nos processos de análise e decisão. Adicionalmente, pretende conduzir, após análise dos resultados e avaliação das contribuições a empresa estudada, a um modelo informacional adequado para gerir as operações de outras empresas de mineração e metalurgia com características semelhantes.

  9. Muhammad Ali, um outsider na sociedade americana?

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    Flávio Py Mariante Neto

    2010-12-01

    Full Text Available O estudo analisa a carreira do boxeador Muhammad Ali segundo as formulações sobre as relações de poder em configurações apresentadas por Norbert Elias. O propósito foi compreender como um atleta que foi contra questões tão profundas da sociedade estabelecida obteve sucesso profissional. Tratou-se de um estudo documental, tendo como fonte livros, artigos e reportagens publicadas sobre a trajetória do lutador. Concluiu-se que apesar de Ali ter se posicionado contra padrões estabelecidos de sua época em questões como a religião, o racismo e o patriotismo, a sua habilidade técnica acima da média, o seu poder de autopromoção e a sua capacidade de participar do jogo no contexto configuracional de que fazia parte, lhe deram condições de sobrevivência no mundo do boxe e conseqüente sucesso profissional.

  10. Adiposity, lipogenesis, and fatty acid composition of subcutaneous and intramuscular adipose tissues of Brahman and Angus crossbred cattle.

    Science.gov (United States)

    Campbell, E M G; Sanders, J O; Lunt, D K; Gill, C A; Taylor, J F; Davis, S K; Riley, D G; Smith, S B

    2016-04-01

    The objective of this study was to demonstrate differences in aspects of adipose tissue cellularity, lipid metabolism, and fatty and cholesterol composition in Angus and Brahman crossbred cattle. We hypothesized that in vitro measures of lipogenesis would be greater in three-fourths Angus progeny than in three-fourths Brahman progeny, especially in intramuscular (i.m.) adipose tissue. Progeny ( = 227) were fed a standard, corn-based diet for approximately 150 d before slaughter. Breed was considered to be the effect of interest and was forced into the model. There were 9 breed groups including all 4 kinds of three-fourths Angus calves: Angus bulls Angus-sired F cows ( = 32), Angus bulls Brahman-sired F cows ( = 20), Brahman-sired F bulls Angus cows ( = 24), and Angus-sired F bulls Angus cows ( = 20). There were all 4 kinds of three-fourths Brahman calves: Brahman bulls Brahman-sired F cows ( = 21), Brahman bulls Angus-sired F cows ( = 43), Brahman-sired F bulls Brahman cows ( = 26), and Angus-sired F bulls Brahman cows ( = 13). Additionally, F calves (one-half Brahman and one-half Angus) were produced only from Brahman-sired F bulls Angus-sired F cows ( = 28). Contrasts were calculated when breed was an important fixed effect, using the random effect family(breed) as the error term. Most contrasts were nonsignificant ( > 0.10). Those that were significant ( Angus > F, three-fourths Brahman > F, and three-fourths crossbred progeny combined > F), s.c. adipocyte volume (three-fourths Angus > F and three-fourths bloods combined > F), lipogenesis from acetate in s.c. adipose tissue (three-fourths Brahman calves from Brahman dams > three-fourths Brahman calves from F dams), and percentage 18:3-3 in s.c. adipose tissue (three-fourths Brahman calves from Brahman-sired F dams Angus-sired F dams). Intramuscular adipocyte volume ( Angus cattle. Additionally, several differences were observed in i.m. adipose tissue that were consistent with this being a less-developed adipose

  11. Pharmacokinetic behavior of enrofloxacin and its metabolite ciprofloxacin in urutu pit vipers (Bothrops alternatus) after intramuscular administration.

    Science.gov (United States)

    Waxman, Samanta; Prados, Ana Paula; de Lucas, José Julio; San Andrés, Manuel Ignacion; Regner, Pablo; de Oliveira, Vanesa Costa; de Roodt, Adolfo; Rodríguez, Casilda

    2014-03-01

    Enrofloxacin is widely used in veterinary medicine and is an important alternative to treating bacterial infections, which play an important role as causes of disease and death in captive snakes. Its extralabel use in nontraditional species has been related to its excellent pharmacokinetic and antimicrobial characteristics. This can be demonstrated by its activity against gram-negative organisms implicated in serious infectious diseases of reptile species with a rapid and concentration-dependent bactericidal effect and a large volume of distribution. Pharmacokinetic parameters for enrofloxacin were investigated in seven urutu pit vipers (Bothrops alternatus), following intramuscular injections of 10 mg/kg. The plasma concentrations of enrofloxacin and its metabolite, ciprofloxacin, were measured using high-performance liquid chromatography. Blood samples were collected from the ventral coccygeal veins at 0.5, 1, 2, 4, 8, 12, 24, 36, 48, 72, 96, 108, and 168 hr. The kinetic behavior was characterized by a relatively slow absorption (time of maximal plasma concentration = 4.50 +/- 3.45 hr) with peak plasma concentration of 4.81 +/- 1.12 microg/ml. The long half-life during the terminal elimination phase (t1/2 lambda = 27.91 +/- 7.55 hr) of enrofloxacin after intramuscular administration, calculated in the present study, could suggest that the antibiotic is eliminated relatively slowly and/or the presence of a slow absorption in urutu pit vipers. Ciprofloxacin reached a peak plasma concentration of 0.35 microg/ml at 13.45 hr, and the fraction of enrofloxacin metabolized to ciprofloxacin was 13.06%. If enrofloxacin's minimum inhibitory concentration (MIC90) values of 0.5 microg/ml were used, the ratios AUC(e+c): MIC90 (276 +/- 67 hr) and Cmax(e+c): MIC90 (10 +/- 2) reach the proposed threshold values (125 hr and 10, respectively) for optimized efficacy and minimized resistance development when treating infections caused by Pseudomonas. The administration of 10 mg/kg of

  12. Safety and effectiveness of rapid-acting intramuscular olanzapine for agitation associated with schizophrenia – Japan postmarketing surveillance study

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    Katagiri H

    2018-01-01

    Full Text Available Hideaki Katagiri,1 Masanori Taketsuna,2 Shinpei Kondo,3 Kenta Kajimoto,4 Etsuko Aoi,5 Yuka Tanji1 1Bio Medicine, 2Statistical Sciences, 3Post Marketing Study Management, 4Scientific Communications, Medicines Development Unit Japan, 5Global Patient Safety Japan, Quality and Patient Safety, Eli Lilly Japan K.K., Kobe, Japan Objective: The objective of this study was to evaluate the safety and effectiveness of rapid-acting intramuscular (IM olanzapine in the treatment of acute agitation associated with schizophrenia in real-world clinical settings in Japan.Methods: In this multicenter, postmarketing surveillance (PMS study, patients with acute agitation associated with schizophrenia were treated with IM olanzapine daily in a daily clinical setting. The observational period ranged from 1 to 7 days, including the day of initial administration. Safety was assessed by reporting treatment-emergent adverse events (TEAEs and adverse drug reactions (ADRs. The Positive and Negative Syndrome Scale – Excited Component (PANSS-EC score was used to evaluate effectiveness at baseline and at 2 hours (after each administration, 2 days, and 3 days (end of the observational period from the last administration of the IM olanzapine injection.Results: The safety analysis set included 999 patients, and the initial dose of 10 mg was administered to 955 patients. TEAEs were reported in 28 patients (36 events, the most common of which were dyslalia (5 patients, akathisia and somno­lence (4 patients each, hepatic function abnormal (3 patients, and constipation and dehydration (2 patients each. One serious adverse event of akathisia occurred during the observation period. The PANSS-EC score (mean ± standard deviation was 23.3±6.4 (n=625 at baseline, 16.9±7.0 (n=522 at 2 hours after initial injection, and 14.9±6.5 (n=650 at the last observation carried forward.Conclusion: The results of this Japanese PMS study demonstrated that IM olanzapine is safe and has a

  13. Repeated dose intramuscular injection of the CIMAvax-EGF vaccine in Sprague Dawley rats induces local and systemic toxicity.

    Science.gov (United States)

    Mancebo, A; Casacó, A; González, B; Ledón, N; Sorlozabal, J; León, A; Gómez, D; González, Y; Bada, A M; González, C; Arteaga, M E; Ramírez, H; Fuentes, D

    2012-05-09

    CIMAvax-EGF consists of a human recombinant epidermal growth factor (EGF), coupled to P64k, a recombinant carrier protein from N. meningitis, and Montanide ISA 51 as adjuvant. The vaccine immunization induces a specific antibody production, inhibiting the EGF/EGF-R interaction through EGF deprivation. The objective of this study was to assess the CIMAvax-EGF toxicity in Sprague Dawley rats after intramuscular administration of repeated doses (6 months) and at the same time to determine if rat is a relevant species for studying CIMAvax-EGF vaccine. Rats were randomly distributed into four groups: control, Montanide ISA 51, treated with 1× and 15× of human total dose of the antigen. Animals were immunized weekly during 9 weeks, plus 9 immunizations every 14 days. Rats were inspected daily for clinical signs. Body weight, food consumption, and rectal temperature were measured during the administration of doses. Blood samples were collected for hematological, serum biochemical determinations and EGF titles at the beginning, three months and at the end of experimentation. Gross necropsy and histological examination of tissues were performed on animals at the end of the assay. Vaccine provoked the apparition of antibodies against EGF in the rats, demonstrating rat species relevance in these studies. Body weight gain, food and water consumption were not affected. CIMAvax-EGF and Montanide ISA 51 produced local damage at the administration site, showing multiple cysts and granulomas. Both vaccine-treated groups showed neutrophil elevation, besides an AST increase probably related to the damage at the administration site. Rectal temperature was found to be significantly higher in 15× treated group after immunizations, probably induced by the inflammatory process at the injection site. In summary, the clinical pathology findings together with the body temperature results, appear to be caused by the inflammatory reaction at the administration site of the vaccine, mainly

  14. ¿Porqué es importante que el personal docente investigue? Reflexión a partir de resultados de una experiencia de investigación etnográfica

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    Campos Saborío, Natalia

    2015-09-01

    Full Text Available El propósito de este ensayo es analizar resultados de experiencias de investigadoras educativas, con el uso de la etnografía, realizadas en el Instituto de Investigación para el Mejoramiento de la Educación Costarricense (IIMEC, hoy Instituto de Investigación en Educación (INIE, durante los años ochenta y noventa. En este periodo se llevaron a cabo tres proyectos pioneros de investigación etnográfica en educación los cuales versaron sobre interacción verbal, manejo de aula y cambio institucional. La naturaleza de los estudios respecto de construir la realidad educativa, interpretarla, conjuntamente con los sujetos observados, y las acciones educativas efectuadas a partir de los datos recolectados, invitan autora de este ensayo a reflexionar sobre la pregunta: ¿Por qué es importante que el personal docente investigue? En él se destaca cómo los resultados de la investigación cualitativa, etnográfica, contribuyen con la docencia y la acción social en la formación de docentes y se enfatiza la necesidad de que se vivan, analicen, comprendan e interpreten los procesos de la realidad educativa concreta.

  15. Arte, imagem e fotografia: um diálogo possível entre Roland Barthes, Walter Benjamin e Jacques Rancière = Art, image and photography: a possible dialogue between Roland Barthes, Walter Benjamin and Jacques Rancière

    Directory of Open Access Journals (Sweden)

    Voigt, André Fabiano

    2016-01-01

    Full Text Available O presente artigo objetiva estabelecer um diálogo entre três autores que escreveram trabalhos importantes sobre a relação da arte com as imagens e a fotografia. Enquanto os pensamentos de Roland Barthes e Walter Benjamin se assemelham, Jacques Rancière apresenta uma postura dissonante ao analisar arte, imagem e fotografia no interior do que ele chama de regime estético das artes

  16. A BRINQUEDOTECA COMO ESPAÇO DE PROMOÇÃO DA HOSPITALIDADE E GARANTIA DE DIREITOS DA CRIANÇA: um estudo de caso em um hospital da Paraíba

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    Raiane Santana do Rêgo

    2017-09-01

    Full Text Available O ato de brincar está intimamente inserido no contexto da recreação, e inúmeras pesquisas demonstram seus benefícios para o desenvolvimento social e psicológico na fase da infância. Diante de tamanha importância, o brincar foi elevado à categoria de direito fundamental da criança garantido, há tempos, em diversos instrumentos jurídicos internacionais e nacionais. Esta pesquisa objetiva analisar como a inserção das brinquedotecas em hospitais tem ajudado a garantir o “direito de brincar” das crianças, e como estes espaços têm contribuído para a promoção do “bem- entreter”, preceituado pela hospitalidade. A partir de um estudo de caso em um hospital paraibano que atende ao público infantil com câncer, constatou-se que, apesar de dispor do espaço da brinquedoteca, e atender assim a Lei da Brinquedoteca Hospitalar, sem sua efetiva utilização por uma equipe de recreação, qualificada e especializada, e de maneira planejada e contínua, o direito da criança de usufruir deste local para as brincadeiras tão importantes para sua recuperação e tratamento, acaba por não ser garantido.

  17. A multiple-dose, double-blind comparison of intramuscularly and orally administered ketorolac tromethamine and Ketogan in patients with pain following orthopaedic surgery

    DEFF Research Database (Denmark)

    Gebuhr, Peter Henrik; Soelberg, M; Strauss, W

    1994-01-01

    combination product containing the narcotic analgesic, ketobemidone, plus a spasmolytic agent) by intramuscular injection every 1-6 h as needed for pain. When patients were able to tolerate an oral diet and were expected to respond to oral analgesic medication, based on overall pain sensitivity, they were...... and at the end of each day. Both treatments were effective immediately after the first dose and during the subsequent multiple-dose phase. There were no statistically significant differences between ketorolac and Ketogan. The results show that 10-mg doses of ketorolac in intramuscular injections followed by 10......In this multiple-dose, double-blind study 100 patients with moderate, severe or very severe pain following orthopaedic surgery were randomly assigned to receive ketorolac, a non-steroidal anti-inflammatory drug with potent analgesic properties (10 mg), or the standard regimen of Ketogan (a...

  18. Transretroperitoneal CT-guided Embolization of Growing Internal Iliac Artery Aneurysm after Repair of Abdominal Aortic Aneurysm: A Transretroperitoneal Approach with Intramuscular Lidocaine Injection Technique

    Energy Technology Data Exchange (ETDEWEB)

    Park, Joon Young, E-mail: pjy1331@hanmail.net; Kim, Shin Jung, E-mail: witdd2@hanmail.net; Kim, Hyoung Ook, E-mail: chaos821209@hanmail.net [Chonnam National University Hospital, Department of Radiology (Korea, Republic of); Kim, Yong Tae, E-mail: mono-111@hanmail.net [Chonnam National University Hwasun Hospital, Department of Radiology (Korea, Republic of); Lim, Nam Yeol, E-mail: apleseed@hanmail.net; Kim, Jae Kyu, E-mail: kjkrad@jnu.ac.kr [Chonnam National University Hospital, Department of Radiology (Korea, Republic of); Chung, Sang Young, E-mail: sycpvts@jnu.ac.kr; Choi, Soo Jin Na, E-mail: choisjn@jnu.ac.kr; Lee, Ho Kyun, E-mail: mhaha@hanmail.net [Chonnam National University Hospital, Department of Surgery (Korea, Republic of)

    2015-02-15

    This study was designed to evaluate the efficacy and safety of CT-guided embolization of internal iliac artery aneurysm (IIAA) after repair of abdominal aortic aneurysm by transretroperitoneal approach using the lidocaine injection technique to iliacus muscle, making window for safe needle path for three patients for whom CT-guided embolization of IIAA was performed by transretroperitoneal approach with intramuscular lidocaine injection technique. Transretroperitoneal access to the IIAA was successful in all three patients. In all three patients, the IIAA was first embolized using microcoils. The aneurysmal sac was then embolized with glue and coils without complication. With a mean follow-up of 7 months, the volume of the IIAAs remained stable without residual endoleaks. Transretroperitoneal CT-guided embolization of IIAA using intramuscular lidocaine injection technique is effective, safe, and results in good outcome.

  19. "Previsões e Sugestões": um presdente americano em Montevidéu, 1960

    Directory of Open Access Journals (Sweden)

    Roberto García Ferreira

    2014-12-01

    Full Text Available Em março de 1960, o presidente dos EUA, Dwight Eisenhower visitou brevemente Montevidéu por 16 horas. Sua chegada era parte de uma excursão relâmpago que este presidente empreendeu pela América do Sul, em resposta à forte popularidade com que esta parte do continente observava a Revolução Cubana. Em contraste a isto, a política dos EUA gerou resistência Suas objeções cobriam um amplo setor que transcendia a militância comunista, incluindo estudantes universitários. Este trabalho, apoiado com a documentação do Serviço de Inteligência e Enlace (SIE da Polícia de Montevidéu, mostra as importantes características da operação policial implantada para silenciar o forte viés antiamericano que os jovens universitários uruguaios procuravam demonstrar durante aquela visita.

  20. O clima organizacional: um conceito motivador para redução do Turnover

    Directory of Open Access Journals (Sweden)

    João André Tavares Fernandes

    2013-08-01

    Full Text Available Este artigo assume como metodologia de pesquisa qualitativa e tem como objetivo analisar como o clima organizacional pode motivar o colaborador e consequentemente reduzir o índice de turnover nas organizações. Nos dias de hoje, os profissionais procuram muito mais que bons salários e benefícios, eles visam obter, além disso, empregos que forneçam qualidade de vida. Uma vez que as empresas precisam consolidar o relacionamento com seus colaboradores, a fim de manter funcionários qualificados e devidamente familiarizados com seus processos, podendo assim oferecer qualidade e confiabilidade aos seus clientes. É extremamente importante que a organização esteja atenta ao nível de motivação de seus parceiros internos, observando se há um Clima Organizacional satisfatório, que além de incentivar a melhoria na produtividade, irá contribuir para a permanência do colaborador na empresa, reduzindo o turnover, pois o atendimento de suas necessidades pode resultar em níveis crescentes de satisfação, enquanto que a sua ausência pode trazer ameaças a sua integridade.