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Sample records for intramuscular um importante

  1. Triacilglicerol intramuscular: um importante substrato energético para o exercício de endurance Triacilglicerol intramuscular: un importante substrato energético para el ejercicio de endurance Intramuscular triacylglycerol: an important energetic substrate for endurance exercise

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    Mônica Aparecida Belmonte

    2005-04-01

    Full Text Available Os ácidos graxos são uma importante fonte de energia para exercício de endurance. Os ácidos graxos plasmáticos encontram-se disponíveis para as fibras musculares sob a forma de ácidos graxos associados à albumina ou agregados à molécula de triacilglicerol (TAG encontrada nas lipoproteínas. Entretanto, além dessas fontes plasmáticas, a hidrólise do TAG encontrado no músculo também pode contribuir com a oferta de ácidos graxos durante o exercício de endurance. O objetivo do presente trabalho foi realizar uma extensa revisão da literatura sobre a importância do TAG intramuscular como substrato energético. A revisão da literatura sugere que a contribuição dos estoques endógenos de TAG durante a realização do exercício de endurance é bastante relevante. Além disso, pode-se concluir que uma adaptação induzida pelo treinamento de endurance é o aumento dos estoques intramusculares de TAG. Após o treinamento de endurance, também é observado aumento na capacidade de utilização desses estoques. Apesar de parecer importante, a contribuição do TAG intramuscular ainda é motivo de controvérsia na literatura. Essa discrepância de resultados está relacionada às metodologias empregadas para estimar a sua oxidação no exercício. A fim de esgotar este assunto de maneira apropriada, mais pesquisas, com novos métodos (ex.: utilização de isótopos, ressonância magnética nuclear e microscopia eletrônica, precisam ser conduzidas.Los ácidos grasos son una fuente importante de energía para el ejercicio de endurance. Los ácidos grasos plasmáticos se encuentran disponibles en las fibras musculares bajo la forma de ácido graso asociado a la albúmina o agregados a la molécula del triacilglicerol (TAG encontrados en las lipoproteínas. Sin embargo, además de estos fuentes plasmáticas, la hidrólisis de los TAG encontrados en el músculo pueden contribuir también con la oferta de ácidos grasos durante el ejercicio

  2. Curdlan: an important microbial hydrocolloid/ Goma curdlana: um importante hidrocolóide microbiano

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    Elaine Soares Amorim

    2003-05-01

    Full Text Available The use of gums in the food industry is mainly based in its functional properties, which are related to the capacity to prevent or delay a series of physicals phenomenon, having an important role in the stability of many industrialized food. The use of these in the several food productions is indispensable, because they contribute to thickening, gelling, stabilization, suspension, film formation and gums can act as auxiliary agents of processing. Therefore, our objective was evaluated the chemistries physical properties, as well as, the areas of application of the microbial hydrocolloid, curdlan.O uso das gomas na indústria de alimentos baseia-se principalmente no aproveitamento de suas propriedades funcionais, que estão relacionadas à capacidade de prevenir ou retardar uma série de fenômenos físicos, desempenhando papel importante na estabilidade de muitos alimentos industrializados. É indispensável o uso destas na produção de diversos produtos alimentícios, pois contribuem para o espessamento, gelificação, estabilização, suspensão, formação de filme e podem atuar como agentes auxiliares de processamento. Desta forma, o presente trabalho buscou avaliar as propriedades físico-químicas, bem como, as áreas de aplicação da goma curdlana que é um hidrocolóide de origem microbiana.

  3. Tilosina: um importante antibiótico não monitorado em leite no Brasil

    OpenAIRE

    Costa, Rafaela Pinto da; Spisso, Bernardete Ferraz; Pereira, Mararlene Ulberg; Monteiro, Mychelle Alves; Ferreira, Rosana Gomes; Carlos, Betânia de Souza; Oliveira, Angélica Castanheira de

    2015-01-01

    A introdução de agentes antimicrobianos na alimentação animal revolucionou a produção de alimentos no mundo, porém o uso indiscriminado desses agentes podem provocar agravos à saúde da população. Os macrolídeos constituem a segunda classe de antimicrobianos mais usados nos animais em geral, sendo a tilosina presente em um maior número de formulações disponíveis para bovinos. A contaminação do leite por resíduos de tilosina acima dos valores considerados seguros pode constituir um risco potenc...

  4. Corantes como importante classe de contaminantes ambientes - um estudo de caso

    OpenAIRE

    Danielle Palma de Oliveira

    2005-01-01

    As amostras ambientais coletadas na área do Ribeirão dos Cristais, região metropolitana de São Paulo, apresentaram atividade mutagênica sistemática durante os últimos anos. De acordo com estudos já publicados em literatura, essa contaminação estava relacionada ao lançamento de efluentes líquidos de uma indústria de tingimento neste corpo d água. Essa indústria tinge principalmente nylon e poliéster, utilizando em seus processos azo corantes dispersos, entre outros. Os corantes de um produto c...

  5. Ecology of neotropical mistletoes: an important canopy-dwelling component of Brazilian ecosystems Ecologia de ervas-de-passarinho Neotropicais: um importante componente do dossel de ecossistemas brasileiros

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    Rafael Arruda

    2012-06-01

    Full Text Available Mistletoes have been studied in temperate countries regularly because they can be pests of cultivated plants and forest plantations. In comparison with temperate habitats, little is known about the ecology of mistletoes in the Neotropics. More emphasis should be given to neotropical mistletoes because they could be important elements of plant communities, acting as key resources for pollinators, seed dispersers and herbivores. Using a combination of findings from early mistletoe studies and empirical evidence from several recent case studies, we report emerging patterns of mistletoe interactions with associated organisms and propose aims for further studies. There has been increasing interest in working with mistletoes in Brazil. Although there are some data on the ecology of mistletoe seed dispersal, reproductive biology studies are scarce and represent a wide range of fieldwork to be explored. Knowledge of the basic biology of mistletoes will be very important for modeling their spatial distribution using metapopulation or epidemiological approaches. In this review, we summarize the studies conducted in the neotropical region in order to provide a framework for current research and new ideas for future investigations of mistletoes, especially in Brazil.Ervas-de-passarinho têm sim sido regularmente estudadas em países temperados por afetar negativamente espécies cultivadas e florestas manejadas. Em comparação com ambientes temperados pouco se conhece sobre a ecologia das ervas-de-passarinho neotropicais. Desta forma, é necessário maior conhecimento sobre o grupo porque são importantes elementos de comunidades vegetais, atuando como recurso-chave para polinizadores, dispersores de sementes e herbívoros. Através de uma combinação de trabalhos clássicos já publicados com evidências empíricas recentes, nós apresentamos padrões emergentes da interação entre ervas-de-passarinho com os organismos associados e questionamentos para

  6. Chlamydia trachomatis: um importante agente de infecções respiratórias em lactentes de famílias de baixa renda

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    Edna Lucia Souza

    2012-10-01

    Full Text Available OBJETIVOS: Determinar a prevalência de infecção do trato respiratório inferior (ITRI por Chlamydia trachomatis em lactentes internados e descrever as características clínicas, laboratoriais e radiológicas da doença. MÉTODOS: Este foi um estudo do tipo corte transversal, realizado durante um período de 12 meses. Foram incluídos todos os lactentes de até 6 meses internados consecutivamente no Centro Pediátrico Professor Hosannah de Oliveira da Universidade Federal da Bahia, em Salvador, BA, com diagnóstico clínico ou clínico-radiológico de ITRI. O diagnóstico de infecção por C. trachomatis foi realizado através da pesquisa de anticorpos da classe IgM, utilizando-se o ensaio imunoenzimático (ELISA. A prevalência de ITRI por C. trachomatis foi determinada, e foram calculadas as razões de prevalência para essa infecção e variáveis clínicas e laboratoriais. RESULTADOS: Cento e cinquenta e um lactentes realizaram sorologia para C. trachomatis, das quais 15 (9,9% foram positivas. A infecção por C. trachomatis ocorreu unicamente entre os menores de 5 meses, principalmente naqueles menores de 2 meses. Três crianças com infecção por C. trachomatis nasceram de parto cesáreo. Conjuntivite e eosinofilia ocorreram em 33,3% dos casos. As radiografias de tórax se mostraram alteradas em 92% dos casos. Demonstrou-se associação da infecção por C. trachomatis com duração de internação superior a 15 dias (p = 0,0398 e com oxigenoterapia (p = 0,0484. CONCLUSÕES: Houve alta prevalência de ITRI por C. trachomatis na população estudada. A infecção por esta bactéria foi associada a uma forma mais grave da doença, demonstrando a importância de se investigar essa infecção na gestante de forma a evitar o adoecimento de recém-nascidos.

  7. Matriz Metaloproteinase 2: um importante marcador genético para colesteatomas Matrix Metalloproteinase 2: an important genetic marker for cholesteatomas

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    Douglas Salmazo Rocha Morales

    2007-02-01

    Full Text Available Este estudo foi desenvolvido para determinar a presença de MMP2 em colesteatomas humanos e observar se colesteatomas que complicam (invasivos apresentam uma maior expressão imunohistoquímica de Matriz Metaloproteinase 2 (MMP2. Colesteatomas produzem enzimas que causam erosão óssea, como a MMP2. MATERIAL E MÉTODO: Analisamos a expressão imunohistoquímica de MMP2 em colesteatomas invasivos, comparando-os aos latentes. Um estudo de corte transversal com dezenove lâminas e blocos parafinados de colesteatoma, derivados de mastoidectomias, foram desparafinados e submetidos à técnica imunohistoquímica com anticorpos anti-MMP2. RESULTADOS: Os resultados foram expressos em 0 (tênue, + (leve, ++ (moderado e +++ (intenso, de acordo com a intensidade da expressão de MMP2. As expressões 0 e + foram denominadas Fraca e as expressões ++ e +++, Forte. Dos 8 colesteatomas invasivos, 7 apresentaram Forte expressão de MMP2 (87,5%. Com relação aos colesteatomas latentes (11, apenas 3 apresentaram Forte expressão de MMP2 (27,3%, com um teste exato de Fisher significante (p= 0,015. CONCLUSÃO: Colesteatomas expressam MMP2 e colesteatomas invasivos expressam MMP2 com maior intensidade, em relação aos latentes.AIM: This study is to determine the MMP2’s presence in cholesteatomas and whether complicating cholesteatomas show a higher immunohistochemical expression of matrix metalloproteinase 2. Cholesteatoma produces enzymesthat cause bone erosion like Matrixmetalloproteinase 2 (MMP2. MATERIAL AND METHODS: We analyzed the expression of MMP2 in invasive (causing complications compared to latent cholesteatomas (not causing complications. A crosssectional study with nineteen slides and paraffin blocks of cholesteatomas derived from mastoidectomies were located and processed, including 8 invasive and 11 latent cholesteatomas. Immunohistochemical thecnique was empregated to MMP2. RESULTS: The results are expressed as 0, + (to low, ++ and +++(high

  8. Porfiria aguda intermitente, um importante e raro diagnóstico diferencial de abdômen agudo: relato de caso e revisão da literatura

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    Fernando Rogério Lara Ferreira

    2011-12-01

    Full Text Available As porfirias são distúrbios metabólicos relacionados à disfunção enzimática da cadeia de biossíntese do heme, componente fundamental para formação de diversas moléculas. Tal defeito ocasiona um acúmulo de precursores (porfirinas nocivos ao organismo. As porfirias se manifestam de maneira heterogênea através de sintomas neuroviscerais, cutâneos ou ambos, geralmente durante episódio de agudização denominado crise porfírica após a exposição a algum fator precipitante. No presente artigo é relatado caso de crise porfírica inicialmente diagnosticado como abdômen agudo e tratado com laparotomia exploradora inconclusiva, seguido de revisão de literatura. Durante o pós operatório o quadro evoluiu com sinais neurológicos de tetraparesia, tetraplegia e desconforto respiratório que sugeriam o diagnóstico de síndrome de Guillain-Barré, hipótese afastada após análise do líquor que não mostrou dissociação albumino-citológica. Admitida em unidade de terapia intensiva, dado o quadro neurológico e a necessidade de suporte ventilatório, apresentou colúria e crises convulsivas sendo feita a hipótese de crise porfírica, confirmada com a dosagem de porfirinas na urina de 24 horas. Iniciado o tratamento de suporte, porém, sem o uso de derivados do heme devido a indisponibilidade, a paciente evoluiu com infecção hospitalar, disfunção orgânica e óbito. A porfiria deve ser levada em consideração nos casos agudos de dor abdominal de causa desconhecida, associada a sinais neurológicos como paresias, distúrbios hidroeletrolíticos e psiquiátricos, especialmente em pacientes com presença de fatores precipitantes, história de crises recorrentes e história familiar positiva para porfiria.

  9. Intramuscular plasmacytoma

    Energy Technology Data Exchange (ETDEWEB)

    Surov, Alexey [Martin-Luther-University of Halle-Wittenberg, Department of Radiology, Halle (Saale) (Germany); Tcherkes, Anatolij [Martin-Luther-University of Halle-Wittenberg, Department of Hematology/Oncology, Halle (Saale) (Germany); Meier, Frieder [Martin-Luther-University of Halle-Wittenberg, Department of Pathology, Halle (Saale) (Germany)

    2014-11-15

    In multiple myeloma, secondary infiltration of adjacent muscles from bone lesions is common. However, plasmacytoma directly arising within the skeletal musculature is rare. Imaging findings of this rare entity have been described only sporadically. The purpose of this study was to identify the clinical signs and radiological features of intramuscular plasmacytoma (IP). Eleven patients with IP were retrospectively identified in the pathological and radiological databases of our institution. Computed tomography (CT) was performed in nine patients and magnetic resonance imaging (MRI) in four cases. IP presented clinically with local pain in four patients. In one case with involvement of the rectus lateralis muscle of the eye, the patient showed a painless bulbus proptosis. In another patient, IP manifested as a massive bilateral forearm swelling with compartment syndrome. In four patients, IP was identified incidentally on computed tomography during staging examination. On imaging, two patterns of IP were found: intramuscular mass (n = 5) or diffuse muscle infiltration (n = 6). On CT with contrast, IP showed a moderate enhancement. With MRI on T1-weighted images, IP was isointense in comparison to the unaffected musculature, whereas on T2-weighted images, IP showed high signal intensity. After intravenous administration of contrast medium, a slight-to-moderate inhomogeneous enhancement was seen in all cases. IP should be considered in the differential diagnosis of muscle tumors. It manifests with two radiological patterns, either as intramuscular mass or as diffuse muscle infiltration. (orig.)

  10. Hydronephrosis in Schinzel-Giedion syndrome: an important clue for the diagnosis Hidronefrose na síndrome de Schinzel-Giedion: um achado importante para o diagnóstico

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    Lilian Maria José Albano

    2004-01-01

    Full Text Available Schinzel-Giedion syndrome is a rare autosomal recessive disorder characterized by coarse facies, midface retraction, hypertrichosis, multiple skeletal anomalies, and cardiac and renal malformations. Craniofacial abnormalities of this syndrome sometimes resemble a storage or metabolic disease. The pathogenesis of the disease remains unknown. The objective of this report was to emphasize the importance of congenital bilateral hydronephrosis for the diagnosis of Schinzel-Giedion syndrome. We describe the first Brazilian case of a newborn with typical facies, generalized hypertrichosis, cardiac and skeletal anomalies, and bilateral hydronephrosis detected during pregnancy and confirmed later by abdominal ultrasonography. Chromosomal constitution was normal. Of the 35 cases already reported in the literature, 31 presented hydronephrosis, which is considered an important clue in diagnosis. If Schinzel-Giedion syndrome were indexed as a cause of congenital hydronephrosis, its identification would be greatly facilitated, since the majority of the other findings in Schinzel-Giedion syndrome are nonspecific and common to many genetic syndromes.A síndrome de Schinzel-Giedion é uma patologia genética rara de etiologia desconhecida e herança autossômica recessiva. Caracteriza-se pela presença de um fácies grotesco, hipoplasia da porção média da face, hipertricose, múltiplas anomalias esqueléticas, malformações cardíacas e renais.As anomalias craniofaciais desta síndrome podem lembrar o fácies de uma doença metabólica de depósito. O objetivo deste relato foi enfatizar a importância da hidronefrose congênita bilateral no diagnóstico da síndrome de Schinzel-Giedion . Descrevemos o primeiro caso brasileiro de um recém-nascido com fácies típico, hipertricose generalizada, anomalias esqueléticas, cardíacas e hidronefrose bilateral, detectada pela ultrassonografia fetal e, posteriormente, confirmada pelo mesmo método. O estudo cromos

  11. Micronúcleo: um importante marcador biológico intermediário na prevenção do câncer bucal = Micronuclei: an important intermediate biomarker on oral cancer prevention

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    Andrade, Miguel Gustavo Setúbal

    2005-01-01

    Full Text Available A preocupação com a prevenção do câncer da boca e da orofaringe tem motivado diversos estudos epidemiológicos que, apesar de serem úteis em identificar fatores de risco, os indivíduos da amostra já tinham desenvolvido a neoplasia maligna. Outros estudos são conduzidos para investigar a incidência de leucoplasias e segundo tumor primário em indivíduos submetidos a um determinado agente de prevenção. Nesses estudos, entretanto, as alterações celulares são constatadas num momento avançado. Este trabalho se propõe a discutir o papel do micronúcleo, uma alteração cromossômica capaz de refletir a exposição dos indivíduos a carcinógenos, como marcador biológico intermediário na prevenção do câncer bucal e na avaliação de estudos prospectivos

  12. Diclofenaco intramuscular no tratamento agudo da migrânea: um estudo duplo cego placebo controlado Intramuscular diclofenac in the acute treatment of migraine: a double-blind placebo controlled study

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    Marcelo E. Bigal

    2002-06-01

    Full Text Available O objetivo do presente estudo é avaliar, com mascaramento duplo, o efeito do diclofenaco sobre a dor e sintomas associados em pacientes com crise de migrânea. Sessenta pacientes com migrânea com aura e sessenta pacientes com migrânea sem aura foram randomizados para receber diclofenaco intramuscular, na dose de 75 mg, associado com injeção intravenosa de solução salina, 10 ml, ou para receber solução salina isoladamente. Três parâmetros de avaliação analgésica e uma escala analógica para avaliar os sintomas associados foram usados. Aferimos ainda os percentuais de recorrência e de utilização de medicação de resgate. Pacientes que receberam diclofenaco apresentaram redução na intensidade da dor estatisticamente significativa, 60 minutos após a administração, em dois dos três parâmetros utilizados (migrânea sem aura e nos três parâmetros utilizados (migrânea com aura. Não observamos diferença, comparado com o placebo, na intensidade dos sintomas associados. Houve redução da recorrência e da utilização de medicação de resgate. A despeito de ser uma opção no tratamento das migrâneas em unidades de emergência, o diclofenaco apresenta início de ação lento e nenhum efeito nos sintomas associados.The aim of this study is to assess, in a double blind fashion, the effect of diclofenac on the pain and associated symptoms in patients with acute migraine. 60 patients with migraine with aura and 60 patients with migraine without aura were assigned at random to receiving intramuscular diclofenac, 75 mg associated to intravenous physiological saline, 10 ml, or physiological saline alone. We used 3 parameters of analgesic evaluation and an analogical scale to asses associated symptoms. We also observed the recurrence and rescue medication percentiles. Patients receiving diclofenac showed a statistically significant improvement of pain 60 minutes after the administration in two of the three parameters

  13. Development of a new experimental model of intramuscular electrical stimulation of the diaphragm in rabbits Desenvolvimento de um novo modelo experimental de estimulação elétrica intramuscular do diafragma em coelhos

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    Rodrigo Guellner Ghedini

    2010-12-01

    Full Text Available PURPOSE: To develop an animal model of diaphragmatic electrical stimulation able to generate an appropriate ventilatory support through the direct implantation of electrodes in the diaphragm (electroventilation. METHODS: Six New Zealand female rabbits (2-3 kg were placed on mechanical ventilation. Then, a laparotomy was performed in order to identify the motor points in each hemidiaphragm, followed by the implantation of the electrodes for diaphragmatic stimulation. We tested two types of electrodes according to the conduction of electrical stimulation: unipolar and bipolar. The electrodes were placed on different occasions in the same animals and tested with current intensities of 20, 26 and 32 mA. Each current intensity was repeated three times for 10 respiratory cycles with 1 minute interval between each cycle, and 5 minutes for new current intensity. We recorded the relationship between current intensity and inspiratory volume. RESULTS: The electrodes adequately stimulate the diaphragm and obtain inspired volumes using different intensity currents. The bipolar electrode generated inspiratory volumes as high as 4.5 times of baseline while the unipolar electrode reached up to 3.5 times of baseline. CONCLUSION: This model has proved to be effective for studying the performance of the diaphragm under different electrical stimulations using different set of electrodes.OBJETIVO: Desenvolver um modelo animal de estimulação elétrica diafragmática capaz de gerar um suporte ventilatório adequado através da implantação direta de eletrodos no diafragma (eletroventilação. MÉTODOS: Seis coelhas da raça Nova Zelândia (2-3 kg foram colocadas em ventilação mecânica. Através de uma laparotomia foram identificados os pontos motores em ambas as cúpulas diafragmáticas, seguido pela implantação dos eletrodos para estimulação diafragmática. Foram testados dois tipos de eletrodos de acordo com a condução do estímulo elétrico: unipolar e

  14. História da psicologia social no Rio de Janeiro: dois importantes personagens

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    Renato Sampaio Lima

    2009-08-01

    Full Text Available A psicologia social de meados da década de 1960 e início da década de 1970 conheceu, segundo alguns autores, o que se denominou "crise". Nas décadas seguintes, as discordâncias teóricas e metodológicas presentes neste campo evidenciaram não apenas posições antagônicas em relação a temas importantes no campo da psicologia social, como também deram visibilidade a alguns autores que representavam estas rivalidades. No Brasil e, mais especificamente no Rio de Janeiro, dois personagens importantes tiveram seus nomes e suas obras relacionados a estes antagonismos: Schneider e Rodrigues. Nosso objetivo será apresentar um relato da história destes importantes personagens da psicologia social no Rio de Janeiro.

  15. El Buen Ordeño es muy Importante

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    Blackman Charles

    1947-06-01

    Full Text Available El ordeño es uno de los mayores trabajos de las fincas lecheras y es también uno de los más importantes. La forma en que se ordeña las vacas determina en gran parte la calidad de la leche e influye además sobre la cantidad de leche producida. Las vacas lecheras deben ser ordeñadas dos veces al día, a intervalos iguales.

  16. Revisión de algunos aspectos importantes

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    J. A. Ávila

    2012-01-01

    Full Text Available El soporte nutricional adecuado y oportuno contribuye en la reducción del riesgo de infecciones, mejora la función inmune y el pronóstico del paciente; es por esto que se destaca la importancia de mantener un adecuado estado nutricional en los pacientes críticamente enfermos. Con este propósito, el presente documento resalta el valor de la nutrición parenteral y su papel en aquellos animales con desnutrición presente o prevista, siempre y cuando la vía enteral no esté disponible o sea insuficiente; esto, en razón de su metabolismo alterado, el cual predispone a un mayor catabolismo mus-cular. La correcta elaboración de un plan nutricional debe tener en cuenta aspectos de gran importancia como la evaluación integral de los hallazgos históricos, clínicos y paraclínicos, con el fin de detectar el grado o riesgo de desnutrición; por su parte, la selección del tipo de nutrición más adecuada y el tipo de solución por emplear, son variables igualmente relevantes pues varían según cada caso particular, dependiendo de la condición del paciente y el tipo de patologías asociadas. Así pues, el cálculo de los requerimientos calóricos y la manera en que estos serán suplementados, son variables que deben manejarse con cautela, con el fin de no exceder la capacidad metabólica y desencadenar complicaciones que representen mayor morbilidad y mortalidad. Por úl-timo, es importante resaltar que la nutrición parenteral debe descontinuarse tan pronto como sea posible para disminuir los problemas relacionados con la misma, como la atrofia gastrointestinal.

  17. Intramuscular variation in mitochondrial functionality of beef ...

    African Journals Online (AJOL)

    Intramuscular color stability variations in beef semimembranosus have been reported previously. Mitochondria remain biochemically active in postmortem muscle and can influence fresh beef color stability. However, the role of mitochondrial functionality in intramuscular color variations in beef semimembranosus is yet to be ...

  18. Ultrastructure of developing human intramuscular nerves

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    Guilberto Minguetti

    1979-12-01

    Full Text Available Terminações nervosas intramusculares são observadas já na nona semana de vida intra-uterina e consistem de grupos de axônios não mielinizados, de diâmetro variável, envolvidos por poucas células de Schwann e sem nenhum espaço entre os axolemas. Nesta e nas fases imediatamente seguintes as células de Schwann são comumente vistas em mitose. Na décima segunda semana, pequenos espaços preenchidos por fibras colágenas aparecem entre os axônios que são agora envolvidos em pequenos grupos ou individualmente pelas células de Schwann as quais , por sua vez, aparecem em maior número. Naqueles axônios únicos a célula de Schwann envolvente apresenta mesaxônios, o que constitue nos primeiros sinais de mielinização. Ainda nesta fase não observadas células perineurais pouco diferenciadas. Por volta da décima sexta semana os axônios e o perineuro atingem um grau avançado de diferenciação, embora ainda não se possa visualizar bainhas de mielina. Somente na décima oitava semana de desenvolvimento é que são visualizadas as bainhas de mielina com suas típicas incisuras de Schmidt-Lantermann e nodos de Ranvier perfeitamente formados. Ainda na décima oitava semana aparecem perfeitamente formados os "vasa nervorum" que se dispõem no sentido longitudinal das fibras nervosas, envoltos pelo tecido conjuntivo das mesmas. Da vigésima oitava semana em diante o aspecto encontrado é semelhante ao das terminações nervosas do adulto.

  19. Intramuscular lipoma of the subscapularis muscle

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    Debora Balabram

    Full Text Available CONTEXT: Intramuscular lipomas are benign tumors that infiltrate the muscles. CASE REPORT: We describe the case of a 58-year-old female patient with an axillary lump. The lump was a lipoma inside the subscapularis muscle. It is important to differentiate these lesions from liposarcomas and from other diseases that may present as axillary lumps. The most accurate imaging method for differentiating benign lipomatous tumors from liposarcomas is magnetic resonance imaging, but surgical removal of these intramuscular lesions to confirm the diagnosis is recommended. CONCLUSION: Intramuscular lipomas are a rare cause of benign axillary lumps and should be considered in making differential diagnoses on axillary masses.

  20. Intramuscular hemangioma. The diagnostic value of MRI

    International Nuclear Information System (INIS)

    Kadota, Tetsuya; Sumino, Teruyuki; Doi, Yasushi; Ozaki, Jiro; Tatsumi, Hideaki

    1999-01-01

    Intramuscular hemangiomas are relatively rare tumors of young adults. It is difficult for the tumors to be diagnosed preoperatively because plain and CT radiographic examinations may not always be specific to them. Ten cases of intramuscular hemangioma are reported. MR examinations were performed on all ten patients with pathologically proved intramuscular hemangioma. Three characteristics of MR findings are shown, using the results of the literature and of our 10 cases. MRI, especially T 2 -weighted image, supplies valuable information to evaluate the local extent of the tumor. MR examination is highly useful and indispensable for attaining a preoperative diagnosis. (author)

  1. Interferon Beta-1a Intramuscular Injection

    Science.gov (United States)

    Interferon beta-1a intramuscular injection is used to reduce the number of episodes of symptoms and slow the development ... problems with vision, speech, and bladder control). Interferon beta-1a is in a class of medications called ...

  2. Cellulitis Developing After Intramuscular Metamizole Injection

    Directory of Open Access Journals (Sweden)

    Onur Ozturk

    2016-12-01

    Full Text Available If the suitable technique is not used in intramuscular injection applications and the injection area is not detected correctly, complications may be observed. Our patient was given intramuscular Metamizole in his house and then he had cellulitis with necrosis area. Following an antibiotic treatment, tissue defect was primarily covered with gluteal muscle skin flap. Cellulitis development after metamizole injection is not common still potential side effects should be considered before prescription.

  3. Unusual intramuscular lipoma of deltoid muscle.

    Science.gov (United States)

    Kapetanakis, Stylianos; Papathanasiou, Jiannis; Dermon, Antonios; Dimitrakopoulou, Alexandra; Ververidis, Athanasios; Chloropoulou, Pelagia; Kazakos, Konstantinos

    2010-01-01

    Lipomas are common soft tissue tumors usually located under the skin. Nevertheless, intramuscular lipomas of deltoid muscle are unusual tumors. We present a case of 74-year-old woman with an intramuscular like clepsydra lipoma of deltoid muscle. The lesion was a palpable soft mass at the lateral side of the humerus. The patient had no previous history of trauma. The main symptom was pain only in abduction and extension. Imaging, pathological findings and surgical excision are discussed.

  4. Nicolau Syndrome after Intramuscular Injection: 3 Cases

    Directory of Open Access Journals (Sweden)

    Seok-Kwun Kim

    2012-05-01

    Full Text Available Nicolau syndrome is a rare complication of intramuscular injection consisting of ischemic necrosis of skin, soft tissue, and muscular tissue that arises locoregionally. The characteristic pattern is pain around the injection site, developing into erythema, a livedoid dermatitis patch, and necrosis of the skin, subcutaneous fat, and muscle tissue. Three patients were injected with drugs (diclofenac sodium, ketoprofen, meperidine for pain relief. Three patients complained of pain, and a skin lesion was observed, after which necrosis developed on their buttocks. Each patient underwent debridement and coverage. The wound healed uneventfully. We report three cases of Nicolau syndrome in the buttocks following diclofenac intramuscular injection.

  5. Intravenous and intramuscular magnesium sulphate regimens in ...

    African Journals Online (AJOL)

    1993-09-03

    Sep 3, 1993 ... parenterally, usually according to one of two popular regimens: the intramuscular (IM) regimen introduced by. Pritchard' and a continuous intravenous (IV) infusion described by Zuspan! Sibai et a/.3 have reported that lower serum magnesium values are achieved with Zuspan's regimen (maintenance dose ...

  6. Epidural and intramuscular pethidine - a pharmacokinetic study ...

    African Journals Online (AJOL)

    Epidural preservative-free pethidine hydrochloride 0,75 mg/kg is rapidly absorbed into the blood. At 1,5 mg/kg the plasma levels reached are similar to those achieved by intramuscular preservative-free pethidine hydrochloride, as is the time course. Plasma levels fall more rapidly after epidural pethidine, Since the plasma ...

  7. pethidine study Epidural and intramuscular a pharmacokinetic

    African Journals Online (AJOL)

    1983-02-05

    Feb 5, 1983 ... Eleven patients received intramuscular and 10 epidural pethidine. Premedication was with oral diazepam 10 mg 2 hours pre- operatively. Two patients in the epidural group received meto- clopramide 10 mg intravenously for nausea during the trial. Bupi\\·acaine 0,5% (plain) was used for all skin infiltration.

  8. Intramuscular compared to intravenous midazolam for paediatric ...

    African Journals Online (AJOL)

    Background: Sedation in children remains a controversial issue in emergency departments (ED). Midazolam, as a benzodiazepine is widely used for procedural sedation among paediatrics. We compared the effectiveness and safety of two forms of midazolam prescription; intramuscular (IM) and intravenous (IV). Patients ...

  9. fetal survival and neonatal growth with intramuscular

    African Journals Online (AJOL)

    FETAL SURVIVAL AND NEONATAL GROWTH WITH INTRAMUSCULAR. INJECTIONS OF FOLATE DURING GESTATION IN THE RAT. 1s. c. lkpo, 1e. o. Agu* and 22M. Ofuya. DEPARTMENT OF ANIMAL AND ENVIRONMENTAL BIOLOGY,. 20EPARTMENT or HUMAN PHYSIOLOGY. UNIVERSITY or PORT HARCOURT, ...

  10. Generalized intramuscular granulocytic sarcoma mimicking polymyositis

    Energy Technology Data Exchange (ETDEWEB)

    Fritz, Jan; Claussen, Claus D.; Pereira, Philippe L.; Horger, Marius S. [Eberhard-Karls-University, Department of Diagnostic Radiology, Tuebingen (Germany); Vogel, Wichard [Eberhard-Karls-University, Department of Internal Medicine-Oncology, Tuebingen (Germany); Wehrmann, Martin [Eberhard-Karls-University, Department of Pathology, Tuebingen (Germany)

    2007-10-15

    We report a case of granulocytic sarcoma exclusively manifesting as diffuse intramuscular infiltration of the proximal upper and lower limb girdle and the torso muscles in a patient with previous history of acute myelogenous leukemia 5a. Whole-body CT showed widespread distribution of ill-defined intramuscular, homogeneously enhancing lesions. On whole-body MRI, lesions were homogeneously hyperintense on fat saturated T2-weighted images, isointense on T1-weighted images and strongly enhancing after intravenous gadolinium contrast administration. Histopathology revealed muscular infiltration of blast cells with identical immunochemistry to the initial manifestation of leukemia, diagnostic for an extramedullary relapse manifesting as granulocytic sarcoma. CT and MRI characteristics of this previously undocumented manifestation of granulocytic sarcoma should assist in the identification of such cases. (orig.)

  11. Nicolau syndrome following intramuscular benzathine penicillin

    Directory of Open Access Journals (Sweden)

    De Sousa R

    2008-01-01

    Full Text Available Nicolau syndrome (NS is a rare complication of an intramuscular injection characterized by severe pain, skin discoloration, and varying levels of tissue necrosis. The case outcomes vary from atrophic ulcers and severe pain to sepsis and limb amputation. We describe a case of a seven-year-old boy with diagnosis of NS after intramuscular benzathine penicillin injection to the ventrolateral aspect of the left thigh. Characteristic violaceous discoloration of skin and immediate injection site pain identified it as a case of NS. The case was complicated by rapid progression of compartment syndrome of the lower limb, proceeding to acute renal failure and death. Associated compartment syndrome can be postulated as a poor prognostic factor for NS.

  12. Two Intramuscular Lipoma Case Reports: Radiological Findings

    Directory of Open Access Journals (Sweden)

    Ayse Umul

    2016-09-01

    Full Text Available Lipomas are common soft tissue tumors of mesenchymal origin.They contain mature adipose tissue. They are usually located in the subcutaneous tissue. They rarely ocur within the muscle and then are called intramuscular lipomas. Ultrasonography is the first diagnostic method to be selected. However, cross-sectional imaging methods are more useful in the diagnosis. On Magnetic resonance imaging (MRI, with the help of signal characteristics and fat suppression techniques,diagnosis is easily achieved. In addition, the relationship of lesion with the adjacent anatomical structures can be assessed better with MRI. Here, will be explained two different intramuscular lipoma cases and imaging findings will be reviewed. [J Contemp Med 2016; 6(3.000: 221-225

  13. História da psicologia social no Rio de Janeiro: dois importantes personagens

    OpenAIRE

    Lima,Renato Sampaio

    2009-01-01

    A psicologia social de meados da década de 1960 e início da década de 1970 conheceu, segundo alguns autores, o que se denominou "crise". Nas décadas seguintes, as discordâncias teóricas e metodológicas presentes neste campo evidenciaram não apenas posições antagônicas em relação a temas importantes no campo da psicologia social, como também deram visibilidade a alguns autores que representavam estas rivalidades. No Brasil e, mais especificamente no Rio de Janeiro, dois personagens importantes...

  14. Intramuscular Gluteal Augmentation: The XYZ Method.

    Science.gov (United States)

    Gonzalez, Raul; Gonzalez, Ricardo

    2018-04-01

    Although interest in buttocks implant procedures is growing around the world, it remains a technically demanding procedure. The intramuscular plane is thought to be superior to other planes of dissection. Asymmetry and visibility of the implants remain frequent complications when the surgeon works without any reference points to guide the procedure. The XYZ method helps the surgeon to obtain symmetry, to significantly reduce implant visibility and to decrease other complications associated with buttocks implants. The method uses the surface anatomy of the boney frame of the pelvis to perform a geometric plane to detach the muscle. Published by Elsevier Inc.

  15. Intramuscular and rectal therapies of acute seizures.

    Science.gov (United States)

    Leppik, Ilo E; Patel, Sima I

    2015-08-01

    The intramuscular (IM) and rectal routes are alternative routes of delivery for antiepileptic drugs (AEDs) when the intravenous route is not practical or possible. For treatment of acute seizures, the AED used should have a short time to maximum concentration (Tmax). Some AEDs have preparations that may be given intramuscularly. These include the benzodiazepines (diazepam, lorazepam, and midazolam) and others (fosphenytoin, levetiracetam). Although phenytoin and valproate have parenteral preparations, these should not be given intramuscularly. A recent study of prehospital treatment of status epilepticus evaluated a midazolam (MDZ) autoinjector delivering IM drug compared to IV lorazepam (LZP). Seizures were absent on arrival to the emergency department in 73.4% of the IM MDZ compared to a 63.4% response in LZP-treated subjects (p administration as solutions, gels, and suppositories. In a placebo-controlled study, diazepam (DZP) was administered at home by caregivers in doses that ranged from 0.2 to 0.5 mg/kg. Diazepam was superior to placebo in reduced seizure frequency in children (p intramuscularly and DZP given rectally appear to have the properties required for rapid enough absorption to be useful when intravenous routes are not possible. Some drugs cannot be administered rectally owing to factors such as poor absorption or poor solubility in aqueous solutions. The relative rectal bioavailability of gabapentin, oxcarbazepine, and phenytoin is so low that the current formulations are not considered to be suitable for administration by this route. When administered as a solution, diazepam is rapidly absorbed rectally, reaching the Tmax within 5-20 min in children. By contrast, rectal administration of lorazepam is relatively slow, with a Tmax of 1-2h. The dependence of gabapentin on an active transport system, and the much-reduced surface area of the rectum compared with the small intestine, may be responsible for its lack of absorption from the rectum. This

  16. Histological properties of intramuscular connective tissues in native ...

    African Journals Online (AJOL)

    The conventional histological study revealed that except the endomysium which was similar in both muscles, the other intramuscular connective tissues' layers varied between leg and breast muscles and were affected by sex. All the connective tissue fibers were observed in all the intramuscular connective tissues of both ...

  17. Intramuscular penicillin is more effective than oral penicillin in ...

    African Journals Online (AJOL)

    Data were not pooled because of clinical and methodological heterogeneity of the trials. Four trials (1 098 patients) compared intramuscular with oral penicillin and all showed that intramuscular penicillin was more effective in reducing RF recurrence and streptococcal throat infections than oral penicillin. One trial (360 ...

  18. Uma análise dos atributos importantes no processo de decisão de compra de notebooks utilizando análise fatorial e escalonamento multidimensional.

    Directory of Open Access Journals (Sweden)

    Valter Afonso Vieira

    2006-12-01

    Full Text Available Identificar atributos importantes no processo decisório do consumidor é uma tarefa árdua para profissionais de marketing. Diversos são os segmentos que necessitam de tais tipos de pesquisas. Com base nesse contexto, este artigo tem como objetivo identificar os atributos importantes considerados pelos consumidores na compra de notebook. Para tal fim, realizou-se uma pesquisa exploratória-qualitativa por meio da entrevista de profundidade com profissionais da área de informática e com potenciais compradores de notebook. Os resultados, após análise de conteúdo, demonstraram 42 atributos considerados para a compra. Em um segundo momento foi realizada uma etapa quantitativa tipo survey com uma amostra bola-de-neve de 131 entrevistados. Assim, após aplicação da análise fatorial exploratória, cinco dimensões foram identificadas, correspondendo aos atributos mais importantes para o processo de decisão de compra. As dimensões foram classificadas como prazer e benefício, características do aparelho, desempenho, cautela e operacional. Por fim, conclusões finais e pesquisas futuras são apresentadas e discutidas.

  19. Intramuscular degeneration process in Duchenne muscular dystrophy

    International Nuclear Information System (INIS)

    Hasegawa, Takeshi; Matsumra, Kiichiro; Hashimoto, Takahiro; Ikehira, Hiroo; Fukuda, Hiroshi; Tateno, Yukio.

    1992-01-01

    Intramuscular degeneration process of Duchenne dystrophy skeletal muscles was investigated by longitudinal skeletal muscle imaging with high-field-strength NMR-CT of 1.5 Tesla. Thigh muscles in 10 cases ranging in age from 4 to 19 years were examined by T 1 -weighted longitudinal images (TR=215∼505 ms, TE=19∼20 ms). The following results were obtained. Skeletal muscle degeneration was depicted as high signal intensity area reflecting its high fat contents. These high signal intensity areas had a longitudinally streaky appearance in parallel direction with myofibers. These findings were more prominent toward myotendon junction than muscle bellies. Skeletal muscle degeneration progressed rapidly between 7 to 10 years of age, and reached a plateau after that. (author)

  20. Magnetic resonance imaging of intramuscular metastases

    Energy Technology Data Exchange (ETDEWEB)

    Surov, Alexey; Spielmann, Rolf-Peter; Behrmann, Curd [Martin-Luther-University Halle-Wittenberg, Department of Radiology, Halle (Germany); Fiedler, Eckhard [Martin-Luther-University Halle-Wittenberg, Department of Dermatology and Venereology, Halle (Germany); Voigt, Wieland [Martin-Luther-University Halle-Wittenberg, Department of Oncology, Halle (Germany); Wienke, Andreas [Martin-Luther-University Halle-Wittenberg, Department of Biometry, Halle (Germany); Holzhausen, Hans-Juergen [Martin-Luther-University Halle-Wittenberg, Department of Pathology, Halle (Germany)

    2011-04-15

    The aim of the present study was to analyse magnetic resonance findings of intramuscular metastases (IM) in a relatively large series. From January 2000 to January 2010, 28 patients (207 metastases) were retrospectively identified in the radiological database of the Martin-Luther-University. Several different scanning protocols were used depending on the localisation of IM. In 12 patients diffusion-weighted (DW) images were obtained with a multi-shot SE-EPI sequence. Apparent diffusion coefficient (ADC) maps were also calculated. Furthermore, fusion images were manually generated between the DW and half-Fourier acquisition single-shot turbo spin echo (HASTE) images. On T2-weighted images, 97% of the recognised IM were hyperintense in comparison to unaffected musculature, and 3% were mixed iso- to hyperintense. On T1-weighted images most IM (91%) were homogeneously isointense in comparison to muscle tissue, whereas 4% were hypointense, and 5% lightly hyperintense. ADC maps were calculated for 91 metastases ranging from 0.99 to 4.00 mm{sup 2}s{sup -1} (mean value 1.99 {+-} 0.66). ADC values of low (<1.5) signal intensity (SI) were identified in 26%, moderate SI (from 1.5 to 3.0) in 68%, and high SI (>3.0) in 6%. Of the IM that were investigated with contrast medium, 88.5% showed marked enhancement. It was homogeneous in 88% and heterogenous in 6%. Rim enhancement with central low attenuation was seen in 6%. There was no difference in enhancement characteristics with respect to ADC values or fusion patterns. Peritumoral enhancement was identified in 2.4%. Magnetic resonance features of muscle metastases are relatively typical and consist of round or oval intramuscular masses with well-defined margins, marked enhancement, low or moderate ADC values, and moderate to high signal intensity on fusion images. (orig.)

  1. Neoclássicos ou neoschumpeterianos : quais os mais importantes para a convergência?

    OpenAIRE

    Sousa, Cândido Tiago Ruivo de

    2010-01-01

    O presente trabalho pretende analisar a convergência absoluta e condicional, e a descoberta de qual das escolas de pensamento é mais importante para o crescimento e convergência, nos 27 Estados Membros da UE. A dissertação é composta por uma revisão de literatura, que transmite as principais técnicas e resultados alcançados. Em seguida são apresentadas as metodologias utilizadas. Para analisar a convergência absoluta foi usado o modelo de Baumol (1986) (convergência β absolu...

  2. Leucinose: estudo de um caso

    Directory of Open Access Journals (Sweden)

    M. Valeriana L. Moura-Ribeiro

    1985-12-01

    Full Text Available Apresentação de um caso de leucinose em recém-nascido do sexo feminino, diagnosticado no 26º dia de vida. O quadro neurológico se caracterizava por alteração do tono muscular, convulsões, letargia e dificuldade respiratória. A demonstração do aumento de aminoácidos de cadeia ramificada através do aminoacidograma constituiu o teste diagnóstico mais importante e o tratamento com MSUD resultou na boa evolução da paciente.

  3. Seguimento de um humano por um robô companheiro

    OpenAIRE

    Amorim, Diogo Samuel Bento

    2016-01-01

    Cada vez mais surgem robôs a partilhar o mesmo espaço físico que os humanos. Deste modo é importante pensar em como os robôs interagem com um humano e na partilha do mesmo espaço que eles. A forma como se movem e reagem passa a ter cada vez mais relevância e é uma componente cada vez mais presente em sistemas robóticos móveis. Aspetos relacionados com a movimentação do robô que não estão diretamente relacionados com comandos rígidos podem ter um impacto muito signi cativo na fo...

  4. Caracterização de novos isolados de Bacillus thuringiensis para o controle de importantes insetos-praga da agricultura

    Directory of Open Access Journals (Sweden)

    Emeline Boni Campanini

    2012-01-01

    Full Text Available A bactéria Bacillus thuringiensis Berliner produz um corpo de inclusão paraesporal (cristal de natureza proteica, formado durante a esporulação, que atua de forma eficiente no controle de insetos-praga de culturas economicamente importantes. Esse cristal é constituído de proteínas Cry, que são codificadas pelos genes cry; um isolado pode ser caracterizado pelo conteúdo de genes cry que apresenta. Visando caracterizar novos isolados no combate de insetos-praga pertencentes às ordens Lepidoptera e Coleoptera, 76 isolados bacterianos foram analisados molecularmente e tiveram seu potencial de controle avaliado por meio de bioensaios com larvas de Spodoptera frugiperda (J.E. Smith, Sphenophorus levis Vaurie e Tenebrio molitor Linnaeus. As análises moleculares indicaram 11 isolados (14,5% da coleção, contendo genes lepidóptero-específicos e 17 (22,37% com genes coleóptero-específicos. As análises de patogenicidade revelaram dois isolados com alto potencial de controle para lagartas de S. frugiperda, um para larvas de S. levis e seis prejudiciais ao desenvolvimento das larvas de T. molitor. Esses isolados de B. thuringiensis podem ser promissores no controle biológico das referidas pragas.

  5. Intramuscular myxoma and fibrous dysplasia of bone - Mazabraud's syndrome

    International Nuclear Information System (INIS)

    Court-Payen, M.; Ingemann Jensen, L.; Bjerregaard, B.; Schwarz Lausten, G.; Skjoldbye, B.

    1997-01-01

    We present a case of Mazabroud's syndrome, a rare benign disease, with multiple intramuscular myxomas of the thoracic wall associated with fibrous dysplasia of bone. CT, MR imaging and ultrasonography (US) of the thorax showed 2 well circumscribed homogeneous intramuscular tumors. A US-guided needle biopsy with a large-core needle (2.0 mm) and a fine needle (0.8 mm) showed that the tumors were intramuscular myxomas with no sign of malignancy. 99m Tc bone scintigraphy showed a markedly increased uptake in the right lower skull, and multiple smaller foci. CT of the skull revealed a right-sided unilateral bone thickening of the orbit and the ethomoidal cells, and right-sided exophthalmia. This case history suggests that patients with multiple intramuscular myxomas should be preoperatively examined for osseous lesions. A postoperative follow-up should also be performed to detect other soft-tissue myxomas not as yet clinically detectable, or rare osseous complications. (orig.)

  6. Neonatal intramuscular injection of plasmid encoding glucagon-like ...

    Indian Academy of Sciences (India)

    Prakash

    -A) was significantly elevated in GP rats. These results suggest that neonatal intramuscular injection of plasmid DNA encoding GLP-1 affects anxiety behaviour in adolescent rats, probably through NGFI-A-activated upregulation of hippocampal ...

  7. Nursing Students and Gluteal Intramuscular Injection

    Directory of Open Access Journals (Sweden)

    Cornwall J

    2011-06-01

    Full Text Available BackgroundNurses are required to perform gluteal intramuscular (IM injections in practice. There are dangers associated with erroneous performance of this task, particularly with dorsogluteal injections. Knowledge regarding safe injection practice is therefore vital for nursing students.Method Fifty-eight second year students at a New Zealand Nursing School were given schematic drawings of the posterior and lateral aspects of the gluteal region. They were asked to mark and justify the safest location for gluteal IM injections.ResultsFifty-seven students marked the dorsal schematic and one the lateral, with 38 (66.7% marking in the upper outer quadrant (UOQ. Twenty indicating the UOQ (52.6% wrote ‘sciatic’ or ‘nerve’ in justifying their location.Nineteen (33.3% marked a location outside the UOQ; nine (47.4% of these mentioned ‘sciatic’ or ‘nerve’ as reasons for injection safety. Overall, 50% of students mentioned ‘sciatic’ or ‘nerve’ in justifying the safety of their chosen injection location.ConclusionResults suggest some second year nursing students do not understand safe gluteal IM injection locations and rationale. Current teaching practices and IM injection techniques could be revisited to prepare students more effectively; this may help prevent pathologies arising from this procedure.

  8. Modelo integral de productividad, aspectos importantes para su implementación

    Directory of Open Access Journals (Sweden)

    Jorge Eduardo Medina Fernández de Soto

    2010-08-01

    Full Text Available El Modelo Integral busca la optimización de la productividad, a partir de los objetivos estratégicos empresariales y el análisis y mejoramiento de la propuesta de valor para el cliente, identificando el nivel de operación óptimo y los recursos tangibles realmente necesarios. También identifica los procesos empresariales de creación de valor y es una guía hacia el desarrollo de la propuesta de valor. Además, analiza las inversiones necesarias para las nuevas propuestas de valor, buscando un crecimiento estratégico sostenible. El artículo explica en primer lugar los fundamentos y componentes del modelo y luego algunos aspectos importantes para su implementación.

  9. Manejar las emociones, factor importante en el mejoramiento de la calidad de vida

    Directory of Open Access Journals (Sweden)

    Sandra Rocío Cano Murcia

    2012-07-01

    Full Text Available En este escrito se resaltarán algunos de los puntos más importantes de la obra de Daniel Goleman, reconocido psicólogo y autor de varios libros, entre ellos ‘’La Inteligencia Emocional’’, con el ánimo de encaminar actividades hacia el establecimiento de hábitos y el fortalecimiento de habilidades emocionales, que conlleven a una sana convivencia y que promueva el mejoramiento de la calidad de vida de cada individuo. Entendiendo esta como el “Bien Estar o Estar Bien” en términos de tranquilidad, paz interior y óptima forma de relacionarnos en sociedad.

  10. O cerrado não é um bioma

    OpenAIRE

    Batalha,Marco Antônio

    2011-01-01

    É importante definirmos corretamente um termo, porque pode haver implicações práticas e imediatas. Dois conceitos importantes para serem definidos acuradamente são os de "cerrado" e de "bioma". Da maneira como vem sendo usado no Brasil, o conceito de bioma adquiriu erroneamente uma conotação florística. Na verdade, o conceito de bioma é similar ao de formação vegetal, mas leva em conta a associação da vegetação com a fauna e com os microrganismos. Assim, por um lado, o conceito de bioma é fis...

  11. AUDIOLIVRO: UMA IMPORTANTE CONTRIBUIÇÃO TECNOLÓGICA PARA OS

    OpenAIRE

    Menezes, Nelijane C.; Franklin, Sérgio

    2008-01-01

    p. 58-72 As tecnologias da informação têm proporcionado modificações históricas na sociedade, propiciando meios de comunicação, baseados em suportes inovadores e recursos informacionais. Este trabalho apresenta, através do estudo de caso desenvolvido na Biblioteca Pública do Estado da Bahia, o audiolivro; um recurso informacional valioso para a formação educacional e o desenvolvimento do hábito de leitura e de pesquisa, para pessoas com necessidades especiais ou não. R...

  12. Necessidades em saúde: questões importantes para o trabalho da enfermagem

    Directory of Open Access Journals (Sweden)

    Edir Nei Teixeira Mandu

    1999-03-01

    Full Text Available A construção de novos parâmetros e práticas em saúde e enfermagem, no sentido do efetivo exercício de direitos sociais, é um desafio posto na atualidade. Este trabalho é uma contribuição ao enfrentamento desse desafio. Olhando para o saber da enfermagem, reflete-se sobre um dado modo de interpretação das necessidades em saúde. A partir de uma discussão acerca das necessidades humanas e de sua relação com o trabalho em saúde, submete-se à crítica a interpretação das necessidades humanas/em saúde presente na teoria de Wanda de Aguiar Horta. Destaca-se na análise a importância da autonomia/autovalorização humana e a interpretação de necessidades a partir da consideração aos sujeitos que recebem-fazem saúde e ao contexto social.

  13. Sexualidad en el anciano: un elemento importante en su calidad de vida

    Directory of Open Access Journals (Sweden)

    Jorge Orihuela de la Cal

    2001-12-01

    Full Text Available Se aplicó un cuestionario a 93 personas mayores de 60 años procedentes de la ciudad de Matanzas y atendidas por el Médico y la Enfermera de la Familia, para abordar algunos aspectos importantes sobre la sexualidad. La actividad e interés sexual se conserva en la mayoría de los hombres, mientras que en las mujeres sobresale la indiferencia. Entre las enfermedades crónicas no transmisibles que padecen están la hipertensión arterial y la artrosis. Los medicamentos más empleados son los sedantes y los antihipertensivos.A questionnaire was applied to 93 persons over 60 from the city of Matanzas that are attended by the family phyisician and nurse to deal with some important aspects about sexuality. Most of men maintain their sexual activity and interest, whereas indifference prevails among women. Arterial hypertension and arthrosis are among the chronic non-comunicable diseases suffered by them. Sedatives and antihypertensives are the most used drugs.

  14. DIAGNÓSTICO GENÉTICO PARA ENFERMEDADES NEURODEGENERATIVAS. UN IMPORTANTE DESAFÍO PARA CHILE

    Directory of Open Access Journals (Sweden)

    Dr. Marcelo Miranda C.

    2016-05-01

    Full Text Available En esta revisión se analizan las características hereditarias de las principales condiciones neurodegenerativas (demencias tipo Alzheimer y frontotemporal, enfermedad de Parkinson y otros cuadros como la enfermedad de Huntington. Se hace énfasis en la necesidad de contar con exámenes genéticos de confirmación diagnóstica en estos cuadros, lo que constituye una falencia en nuestro medio. Disponer de estos recursos diagnósticos permite una mejor aproximación al paciente, estableciendo un diagnóstico más certero, un pronóstico con más base y una asesoría genética adecuada. La implementación de una terapia efectiva para cada cuadro, estará basada en un futuro próximo en un diagnóstico más preciso de la condición del paciente y para esto los estudios genéticos son una herramienta muy importante de la que dispone el clínico, además de estudios de imágenes y de laboratorio con otros marcadores humorales.

  15. La Piedra Caliza El más Importante de los Fertilizantes Naturales

    Directory of Open Access Journals (Sweden)

    Albrecht Wm.

    1947-09-01

    Full Text Available El encalamiento del suelo ha sido por mucho tiempo un arte agrícola. El colocar piedra caliza sobre el terreno, que en otro tiempo se consideró como una labor rutinaria, ha venido a tenerse últimamente como una práctica a la que ahora se le asignan razones de índole científica. Son hechos científicos recientes los que basados en las relaciones existentes entre el suelo y la planta, nos han suministrado los fundamentos sobre los cuales se apoya el mayor rendimiento en las cosechas obtenido con la aplicación de piedra caliza a los suelos. La piedra caliza ha estado siempre a ociada a la producción de plantas leguminosas; las que a su turno se consideran como buen alimento para ganado joven y en crecimiento. Nosotros ahora justamente, nos estamos dando cuenta de que el suministro de calcio es como fertilizante tal como lo consideraron los viejos. El calcio es, en efecto, el más importante de los elementos nutritivos que pueden agregarse al suelo para ayudarlo en la producción de más abundantes cosechas, suministrándonos ellas a su vez una mejor nutrición.

  16. Competencias más importantes para la disciplina administrativa en Colombia

    Directory of Open Access Journals (Sweden)

    Jaime Castrillón

    2015-01-01

    Full Text Available A partir de los resultados encontrados del Proyecto Tuning Latin-America, que se replicó en Colombia, esta investigación identifica de las 47 competencias del proyecto, las 5 más importantes según la percepción de los académicos y de los empleadores, las cuales deben ser tenidas en cuenta para garantizar buenos resultados de los profesionales en administración. Las competencias también se han clasificado de acuerdo con los fundamentos filosóficos de Bédard en ontológicas, axiológicas, epistemológicas, praxiológicas. Este estudio usa una orientación descriptiva cuando se construye el ranking de las competencias y aplica una inferencia estadística para determinar el nivel de importancia de ellas. Los resultados muestran una percepción diferente para académicos y empleadores. Sin embargo, empleadores y académicos piensan que los administradores están orientados a los elementos epistemológicos y praxiológicos, tanto en las competencias genéricas como específicas. Se puede concluir que es necesario hacer un esfuerzo para cerrar la brecha entre los conocimientos y los aspectos prácticos frente a los conceptos éticos, morales y los principios ontológicos mediante una buena educación impartida en las instituciones de educación superior. Derechos Reservados © 2015 Universidad Nacional Autónoma de México, Facultad de Contaduría y Admi- nistración. Este es un artículo de acceso abierto distribuido bajo los términos de la Licencia Creative Commons CC BY-NC-ND 4.0.

  17. Supraspinatus Intramuscular Calcified Hematoma or Necrosis Associated with Tendon Tear

    Directory of Open Access Journals (Sweden)

    Alexandre Lädermann

    2015-01-01

    Full Text Available Introduction. Rotator cuff intramuscular calcification is a rare condition usually caused by heterotopic ossification and myositis ossificans. Case Presentation. We describe a patient with voluminous calcified mass entrapped in supraspinatus muscle associated with corresponding tendon tear. Histological examination corresponded to a calcified hematoma or necrosis. Patient was surgically managed with open excision of the calcified hematoma and rotator cuff arthroscopic repair. At 6 months, supraspinatus muscle was healed, and functional outcome was good. Discussion and Conclusion. We hypothesized that supraspinatus intramuscular calcified hematoma was responsible for mechanical stress on the tendon. This association has never been described.

  18. Can a Clinical Examination Demonstrate Intramuscular Tendon Involvement in Acute Hamstring Injuries?

    NARCIS (Netherlands)

    Crema, Michel D.; Guermazi, Ali; Reurink, Gustaaf; Roemer, Frank W.; Maas, Mario; Weir, Adam; Moen, Maarten H.; Goudswaard, Gert J.; Tol, Johannes L.

    2017-01-01

    Involvement of the intramuscular (central) tendon in acute hamstring injuries, as detected on magnetic resonance imaging (MRI), may prolong recovery times. To date, it is unclear whether hamstring injuries exhibiting intramuscular tendon involvement can be identified though routine clinical

  19. Can a clinical examination demonstrate intramuscular tendon involvement in acute hamstring injuries?

    NARCIS (Netherlands)

    Crema, M.D. (Michel D.); A. Guermazi (Ali); G. Reurink (Gustaaf); Roemer, F.W. (Frank W.); M. Maas (Mario); A. Weir (Adam); M.H. Moen (Maaike); G.J. Goudswaard (Gert Jan); J.L. Tol (Johannes)

    2017-01-01

    textabstractBackground: Involvement of the intramuscular (central) tendon in acute hamstring injuries, as detected on magnetic resonance imaging (MRI), may prolong recovery times. To date, it is unclear whether hamstring injuries exhibiting intramuscular tendon involvement can be identified though

  20. Geodiversidade, Geoconservação e Geoturismo – trinômio importante para a proteção do patrimônio geológico

    OpenAIRE

    Lilian Carla Moreira Bento

    2009-01-01

    RESENHALEITE DO NASCIMENTO, M. A. L. do; RUCHKYS, U. A.; MANTESSO-NETO, V. Geodiversidade, Geoconservação eGeoturismo – trinômio importante para a proteção do patrimônio geológico. São Paulo: Sociedade Brasileira de Geologia,2008. 82 p.Geodiversidade, Geoconservação e Geoturismo– trinômio importante para a proteção dopatrimônio geológico é o primeiro livro brasileiro quetrata dessa temática que surgiu nos países europeus nadécada de 1990 e hoje alcança um público cada vezmais crescente.Lançad...

  1. Intramuscular and epimuscular microstimulation of single motor units

    NARCIS (Netherlands)

    Griep, P.A.M.; Pool, C.W.; Lammerlée, G.C.; Wallinga, W.; Seeder, T.; Donselaar, Yvonne C.

    1980-01-01

    A new epimuscular method for stimulating single motor units (m.u.'s) in free prepared muscle is described. Unit isolation is stable and can be continued for long periods. The method is compared with an intramuscular stimulation technique and histological evidence is presented to confirm the validity

  2. Sciatic nerve palsy associated with intramuscular quinine injections ...

    African Journals Online (AJOL)

    Sct?ior ikfeclical O[ficcr. Department of Orthopaeclics, Mulago Hospital, Makerere University, Kampala, Uganda. Key Words: Sciatic nerve palsy, intramuscular injections, children, quinine dil~ydrochloride. The purpose of this paper is to show that, in children, gluteal injection of quinine dihydrochloride (QDH) may result in ...

  3. Impact of oral and intramuscular administration amoxicillin on the ...

    African Journals Online (AJOL)

    Objective: The aim of this study was to evaluate the level of selection of amoxicillin-resistant Enterobacteriaceae in the digestive microbiota of piglets during oral and intramuscular administration of amoxicillin. Methodology and Results: Enumeration of Enterobacteriaceae was carried out on MacConkey agar with and ...

  4. Intramuscular Injection of “Site Enhancement Oil”

    DEFF Research Database (Denmark)

    Petersen, Maria Louise; Colville-Ebeling, Bonnie; Jensen, Thomas Hartvig Lindkær

    2015-01-01

    The use of intramuscular injection of foreign substances for aesthetic purposes is well known. Complications are usually local to the site of injection but can be potentially lethal. Here, we present a case of "site enhancement oil" use in a 42-year-old man who died from asphyxia due to hanging...

  5. Comparison of intramuscular artemether and intravenous quinine in ...

    African Journals Online (AJOL)

    Objectives: To compare the efficacy of intramuscular artemether and intravenous quinine in the treatment of severe falciparum malaria. Design: An open randomized controlled clinical trial. Setting: New Halfa Teaching Hospital, Eastern Sudan, in the period November 2001-January 2002. Subjects: Forty one male and ...

  6. An Interesting Case of Intramuscular Myxoma with Scapular Bone Lysis

    Directory of Open Access Journals (Sweden)

    Jérôme Tirefort

    2017-01-01

    Full Text Available Introduction. Intramuscular myxoma is a rare benign primitive tumor of the mesenchyme founded at the skeletal muscle level; it presents itself like an unpainful, slow-growing mass. Myxomas with bone lysis are even more rare; only 7 cases have been reported in the English literature, but never at the shoulder level. Case Presentation. We describe an 83-year-old patient with a growing mass in the deltoid muscle with unique scapular lysis, without any symptom. Magnetic resonance imaging (MRI and a biopsy were performed and the diagnosis of intramuscular myxoma has been retained. In front of this diagnosis of nonmalignant lesion, the decision of a simple follow-up was taken. One year after this decision, the patient was still asymptomatic. Conclusion. In the presence of an intramuscular growing mass with associated bone lysis, intramuscular myxoma as well as malignant tumor should be evoked. MRI has to be part of the initial radiologic appraisal but biopsy is essential to confirm the diagnosis. By consensus, the standard treatment is surgical excision but conservative treatment with simple follow-up can be an option.

  7. Intravenous paracetamol versus intramuscular pethidine in relief of ...

    African Journals Online (AJOL)

    Background: Intramuscular pethidine is one of most common opioids used for labour analgesia. There are a number of concerns in the literature regarding the use of pethidine. The aim of this study is to compare analgesic efficacy of paracetamol with pethidine for labour pain in normal vaginal delivery. Materials and ...

  8. Intramuscular cysticercosis – The solitary reaper | Singh | Annals of ...

    African Journals Online (AJOL)

    Occurrence of solitary intramuscular cysticercosis without involvement of the central nervous system is rare. We report a case of solitary cysticercosis of the brachioradialis muscle in a 35-year-old woman who presented with discomfort and pain in the right elbow and arm after trivial trauma. There were no systemic or ...

  9. Sciatic nerve palsy associated with intramuscular quinine injections ...

    African Journals Online (AJOL)

    The purpose of this paper is to show that, in children, gluteal injection of quinine dihydrochloride (QDH) may result in damage to the sciatic nerve. Forty-six children were seen with foot drop following intramuscular injections in the same limb. They were analyzed for the type of injection, injection site, route of injection, the ...

  10. Epidural versus intramuscular pethidine in postoperative pain relief ...

    African Journals Online (AJOL)

    Twenty-one patients received epidural pethidine 0,75 mg/kg in 10 ml normal saline for postoperative analgesia. A control group of 20 patients received intramuscular pethidine 1,5 mg/kg. Respiratory-and cardiovascular parilmeters in both groups were stable, and in both side-effects were similar and not serious. In the ...

  11. Tetanus from Intramuscular Quinine Injection InWarri Niger Delta ...

    African Journals Online (AJOL)

    Aim: To evaluate the development of tetanus from intramuscular injection in children inWarri, Niger Delta of Nigeria Materials and Methods; Retrieval and analysis of case notes of all children with tetanus seen between 1999 and 2008 at Central Hospital Warri with referrals from surrounding General Hospitals and GN ...

  12. Epidural versus In postoperatIve intramuscular pain relief pethidine

    African Journals Online (AJOL)

    Twenty-one patients received epidural pethidine. 0,75 mg/kg in 10 ml normal saline for postoperative analgesia. A control group of 20 patients received intramuscular pethidine 1,5 mg/kg. Respiratory--and cardiovascular parilmeters in both groups were stable, and in both side-effects were similar and not serious. In the ...

  13. Polyostotic fibrous dysplasia associated with intramuscular myxomas: Mazabraud's syndrome

    International Nuclear Information System (INIS)

    Lassance Cabral, C.E.; Guedes, P.; Celso Cruz, L. Jr.; Smith, J.; Rezende, J.F.

    1998-01-01

    Mazabraud's syndrome, though uncommon, is reported increasingly frequently. It represents an entity readily recognisable radiologically on MR imaging. Awareness of the syndrome, particularly when the myxoma is solitary, can prevent misdiagnosis of intramuscular myxomas (especially when large) as malignant mesenchymal tumors containing myxoid tissue. We review the 34 cases previously reported in the literature and include a recent case from our center. (orig.)

  14. The clearance of albumin microspheres from an intramuscular injection site

    International Nuclear Information System (INIS)

    Mills, S.N.; Davis, S.S.; Frier, M.; Hardy, J.G.; Wilson, C.G.

    1982-01-01

    Human serum albumin microspheres of three different diameters were radiolabelled with indium-111, and a suspension injected into rabbit thigh muscle. Clearance from the intramuscular site was monitored for 2 weeks using gamma scintigraphy. The clearance rates were compared with the injection site clearance of non-biodegradable polystyrene microspheres. (U.K.)

  15. Sonographic Appearance of a Solitary Intramuscular Cysticercosis: A Case Report

    International Nuclear Information System (INIS)

    Moon, Ju Hee; Joo, Seung Ho; Shim, Joo Eun; Kim, Yee Jeong; Oh, Hyun Cheol; Kim, Tae Hwan

    2009-01-01

    The development of antiparasitic drugs and public health strategies has reduced the prevalence of cysticercosis in South Korea. In contrast, the disease is still endemic in Southeast Asia. The influx of immigrants from endemic areas has been on the increase. We report the sonographic and pathological findings of cysticercosis that presented as an intramuscular solitary mass in a 27-year-old Philippine woman

  16. The clearance of liposomes administered by the intramuscular route

    International Nuclear Information System (INIS)

    Arrowsmith, M.; Mills, S.N.

    1982-01-01

    Iodine 131-labelled lecithin was used to label liposomes entrapping cortisone-21-palmitate. The lecithin was injected into the fascia latae muscles of rabbits and the percentage of the initial dose remaining at certain time intervals was calculated from gamma camera image data. Release from the intramuscular site occurs by diffusion from intact liposomes. (U.K.)

  17. Indium-111 leukocyte accumulation in intramuscular injection sites

    International Nuclear Information System (INIS)

    Swayne, L.C.; Dolgin, C.; Kabnick, L.S.; Filippone, A.

    1986-01-01

    We report four cases of indium-111 leukocyte concentration in previous intramuscular injection sites. Three patterns were observed: (1) small, discrete, and round; (2) linear; (3) irregular and large. The scintigraphic appearance did not necessarily correlate with the number of injections that the patient had received. (orig.)

  18. Biological effects in intramuscular 239Pu administration during chelatotherapy

    International Nuclear Information System (INIS)

    Sinyakov, E.G.; Nifatov, A.P.; Bazhin, A.G.; Lyubchanskij, Eh.R.

    1988-01-01

    Durable (up to 64 days) application of complexones (Ca and Zn DTPA) in the case of intramuscular administration of 239 Pu large amounts in rats is studied. The results of studying the biological effect proving considerable decrease of the average lifespan of rats are given

  19. Conflito de Interesses em Eventos de Educação Médica Continuada (EMC: o que Palestrantes e Ouvintes Consideram Importante que Seja Declarado?

    Directory of Open Access Journals (Sweden)

    José Domingos Neto

    Full Text Available RESUMO Introdução As companhias farmacêuticas representam a principal fonte de inovações terapêuticas na medicina, daí têm participação importante em eventos de educação médica continuada (EMC. Objetivos Conhecer as concepções de médicos (palestrantes ou ouvintes acerca do significado dos conflitos de interesses em eventos de EMC e que tipo de relação deveria ser declarado. Metodologia Médicos que atuam numa universidade brasileira responderam a um questionário com perguntas abertas e fechadas. Os dados qualitativos foram analisados de acordo com uma análise de conteúdos, e os quantitativos submetidos a análise estatística apropriada. Resultados Setenta e seis médicos responderam ao questionário; 55,3% consideram o conflito de interesses como uma situação, enquanto 44,7% o consideram um comportamento. Além do financiamento de pesquisa relacionada ao tema da palestra, mais da metade dos participantes apontou outros seis tipos de relacionamento indústria/palestrante cuja declaração é desejável. Cinquenta por cento dos palestrantes e 18% dos ouvintes acreditam estar bem preparados para lidar com as indústrias farmacêuticas. Considerações finais Escolas médicas, Conselho Federal de Medicina e Associação Médica Brasileira deveriam trabalhar para aprimorar a compreensão dos médicos acerca do tema e criar regras claras sobre o que deveria ser declarado.

  20. Intramuscular capillary-type hemangioma: radiologic-pathologic correlation

    Energy Technology Data Exchange (ETDEWEB)

    Yilmaz, Sabri; Alomari, Ahmad I.; Chaudry, Gulraiz [Boston Children' s Hospital and Harvard Medical School, Vascular Anomalies Center, Boston, MA (United States); Boston Children' s Hospital and Harvard Medical School, Division of Vascular and Interventional Radiology, Boston, MA (United States); Kozakewich, Harry P. [Boston Children' s Hospital and Harvard Medical School, Vascular Anomalies Center, Boston, MA (United States); Boston Children' s Hospital and Harvard Medical School, Department of Pathology, Boston, MA (United States); Fishman, Steven J. [Boston Children' s Hospital and Harvard Medical School, Vascular Anomalies Center, Boston, MA (United States); Boston Children' s Hospital and Harvard Medical School, Department of Surgery, Boston, MA (United States); Mulliken, John B. [Boston Children' s Hospital and Harvard Medical School, Vascular Anomalies Center, Boston, MA (United States); Boston Children' s Hospital and Harvard Medical School, Department of Plastic and Oral Surgery, Boston, MA (United States)

    2014-05-15

    Infantile hemangiomas demonstrate a pattern of proliferative growth in infancy followed by a slow phase of involution. In contrast a rare type of vascular tumor, intramuscular capillary-type hemangioma, usually presents beyond the period of infancy with nonspecific symptoms and no evidence of involution. The purpose of this study was to characterize the clinical, imaging, histopathological characteristics and management of intramuscular capillary-type hemangioma. We performed a retrospective review of a 20-year period to identify children diagnosed with intramuscular capillary-type hemangioma. Patient demographics, imaging and histopathological findings were recorded. We included 18 children (10 boys, 8 girls) with histologically proven intramuscular capillary-type hemangioma - and adequate imaging. The mean age at presentation was 8.1 years (range 1 day to 19 years). Twelve lesions involved muscles of the extremities, 4 were located in the trunk and 2 were in the head and neck. MRI had been performed in all children and demonstrated a soft-tissue mass with flow voids, consistent with fast flow. The lesion was well-circumscribed in 16 children and intralesional fat was seen in 14. Doppler US demonstrated a heterogeneous lesion, predominantly isoechoic to surrounding muscle, with enlarged arterial feeders. Enlarged feeding arteries, inhomogeneous blush and lack of arteriovenous shunting were noted on angiography (n = 5). The most common histopathological findings were lobules of capillaries with plump endothelium and at least some adipose tissue. The lesions were excised in six children. Two children were lost to follow-up. In the remaining 10, follow-up MRI studies ranging from 3 months to 10 years showed that the lesion enlarged in proportion to the child (n = 7), demonstrated slow growth (n = 2) or remained stable (n = 1). There was no change in imaging characteristics on follow-up. Intramuscular capillary-type hemangioma is a rare benign vascular tumor of

  1. Comparison of intramuscular olanzapine, orally disintegrating olanzapine tablets, oral risperidone solution, and intramuscular haloperidol in the management of acute agitation in an acute care psychiatric ward in Taiwan.

    Science.gov (United States)

    Hsu, Wen-Yu; Huang, Si-Sheng; Lee, Bo-Shyan; Chiu, Nan-Ying

    2010-06-01

    The purpose of this study was to compare efficacy and safety among intramuscular olanzapine, intramuscular haloperidol, orally disintegrating olanzapine tablets, and oral risperidone solution for agitated patients with psychosis during the first 24 hours of treatment in an acute care psychiatric ward. Forty-two inpatients from an acute care psychiatric ward of a medical center in central Taiwan were enrolled. They were randomly assigned to 1 of the 4 treatment groups (10-mg intramuscular olanzapine, 10-mg olanzapine oral disintegrating tablet, 3-mg oral risperidone solution, or 7.5-mg intramuscular haloperidol). Agitation was measured by using the excited component of the Positive and Negative Syndrome Scale (PANSS-EC), the Agitation-Calmness Evaluation Scale, and the Clinical Global Impression--Severity Scale during the first 24 hours. There were significant differences in the PANSS-EC total scores for the 4 intervention groups at 15, 30, 45, 60, 75, and 90 minutes after the initiation of treatment. More significant differences were found early in the treatment. In the post hoc analysis, the patients who received intramuscular olanzapine or orally disintegrating olanzapine tablets showed significantly greater improvement in PANSS-EC scores than did patients who received intramuscular haloperidol at points 15, 30, 45, 60, 75, and 90 minutes after injection. These findings suggest that intramuscular olanzapine, orally disintegrating olanzapine tablets, and oral risperidone solution are as effective treatments as intramuscular haloperidol for patients with acute agitation. Intramuscular olanzapine and disintegrating olanzapine tablets are more effective than intramuscular haloperidol in the early phase of the intervention. There is no significant difference in effectiveness among intramuscular olanzapine, orally disintegrating olanzapine tablets, and oral risperidone solution.

  2. George Orwell -Um Intelectual Militante

    Directory of Open Access Journals (Sweden)

    Sandra dos Santos

    2016-07-01

    Full Text Available George Orwell, pseudônimo de Eric Arthur Blair, representou um importante intelectual na produção de obras literárias do século XX , ao lado de tantos outros autores que denunciaram em seus escritos, os abusos cometidos por governos de regimes totalitários e fascistas.A mudança de nome , que reforçou uma contestação ao seu estilo burguês , a participação em lutas políticas e o caráter revolucionário e denunciativo de suas obras assinalaram parte da vida deste escritor. Este artigo tem por objetivo delinear o perfil de um intelectual engajado, cujos ideais de mudanças e de conscientização estiveram presentes concretamente em suas ações como ativista, assim como em obras cuja importância permanece e se solidifica cada vez mais nos dias atuais.

  3. Muscle enhancement using intramuscular injections of oil in bodybuilding

    DEFF Research Database (Denmark)

    Schäfer, Ch. N.; Hvolris, Jørgen Jesper; Karlsmark, Tonny

    2012-01-01

    BACKGROUND: Self-administered intramuscular injection of site enhancement oil (SEO) is a cosmetic and performance-enhancing procedure used to reshape muscles in the bodybuilder subculture, but its consequences and complications are only sporadically described. Methods: A systematic search...... in MEDLINE and EMBASE databases during the spring of 2009 and 2010. Internet searches were performed, and bodybuilder pharmacopoeias were consulted to describe SEO use and the clinical complications known. Results: One review and seven case reports were identified. Eight case reports describe oleomas caused...... by repeated intramuscular injections of anabolic steroids. Conclusions: SEOs cause sclerosing lipogranulomatosis and its progression may lead to lifelong complications. Thorough radiologic evaluation is important to plan surgical revisions in active phases. Also antibiotics, steroids, and compression therapy...

  4. Intramuscular versus Subcutaneous Administration of Iron Dextran in Suckling Piglets

    Directory of Open Access Journals (Sweden)

    M. Svoboda

    2007-01-01

    Full Text Available The aim of the study was to compare the development of red blood cell indices after subcutaneous versus intramuscular administration of iron dextran to suckling piglets during early postnatal period. The piglets in group I (n = 17 were injected subcutaneously (into groin with 200 mg Fe3+ as iron dextran on day 3 of life. In group II (n = 16, the piglets received intramuscular injection (into gluteal muscles of 200 mg Fe3+ as iron dextran on day 3 of life. In group III (n = 10, the piglets did not receive any iron till the age of 3 days. The blood was taken and analyzed (Hb, PCV, RBC, MCV, MCH, MCHC, Fe on days 3, 7, 14, 21, 28 and 35. Haematological indices of piglets in group III were characteristic for hypochromic anaemia. Anaemia in group III had a detrimental effect on the growth rate of piglets. The development of red blood cell indices and iron concentration in blood plasma in subcutaneously treated piglets did not differ significantly from that of intramuscularly-treated group. Both treatments prevented development of anaemia.

  5. Pharmacokinetics of butafosfan after intravenous and intramuscular administration in piglets.

    Science.gov (United States)

    Sun, F; Wang, J; Yang, S; Zhang, S; Shen, J; Xingyuan, C

    2017-04-01

    The pharmacokinetics and bioavailability of butafosfan in piglets were investigated following intravenous and intramuscular administration at a single dose of 10 mg/kg body weight. Plasma concentration-time data and relevant parameters were best described by noncompartmental analysis after intravenous and intramuscular injection. The data were analyzed through WinNolin 6.3 software. After intravenous administration, the mean pharmacokinetic parameters were determined as T 1/2λz of 3.30 h, Cl of 0.16 L kg/h, AUC of 64.49 ± 15.07 μg h/mL, V ss of 0.81 ± 0.44/kg, and MRT of 1.51 ± 0.27 h. Following intramuscular administration, the C max (28.11 μg/mL) was achieved at T max (0.31 h) with an absolute availability of 74.69%. Other major parameters including AUC and MRT were 48.29 ± 21.67 μg h/mL and 1.74 ± 0.29 h, respectively. © 2016 John Wiley & Sons Ltd.

  6. Há morte nas catacumbas?: um estudo sobre turismo negro

    OpenAIRE

    Coutinho, Belmira Maria dos Santos Gomes

    2012-01-01

    Na sociedade contemporânea, em que a morte é simultaneamente presente e ausente do quotidiano dos indivíduos, é importante identificar as principais instituições que permitem o contacto entre o indivíduo e a morte e as relações que podem ser estabelecidas entre eles. O Turismo Negro, ou seja, a actividade turística em locais de ou associados a morte e sofrimento, é uma das mais importantes instituições mediadoras da morte. O Turismo Negro é um objecto de interesse recente entre a comunidad...

  7. Parkinsonismo induzido pela flunarizina: a propósito de um caso

    Directory of Open Access Journals (Sweden)

    Ivanidton Galhardo

    1993-11-01

    Full Text Available Os autores registram o caso de uma paciente com parkinsonismo induzido pela flunarizina. Ressaltam um aspecto importante, relacionado ao tremor, que assumia características wilsonianas quando realizava a prova índice-nariz. A depressão foi sintoma importante. A cura se efetivou pela retirada da droga e pelo uso de levodopa e de tremaril por período de três meses.

  8. Acute toxicity and radioprotective efficiency of gammaphos injected intramuscularly to mice

    International Nuclear Information System (INIS)

    Kuna, P.

    1985-01-01

    In experiments on mice it was shown that acute toxicity of gammaphos (WR-2721) was 790 mg/kg and 862 mg-kg after intraperitoneal and intramuscular administration, resperctively. Gammaphos in the dose of 100 mg/kg, injected intramuscularly, increased the radioresistance of mice in nearly the same way as cystamine, in the dose of 150 mg/kg, did. The increase in the dose of gammaphos up to 200 or 300 mg/kg, injected intramuscularly, enhanced the radioprotective effect. No change was observed in the radioprotective efficiency of gammaphos after intramuscular injection as compared to intraperitoneal administration of the protective agent in the same dose

  9. Evaluation of Linear Regression Simultaneous Myoelectric Control Using Intramuscular EMG.

    Science.gov (United States)

    Smith, Lauren H; Kuiken, Todd A; Hargrove, Levi J

    2016-04-01

    The objective of this study was to evaluate the ability of linear regression models to decode patterns of muscle coactivation from intramuscular electromyogram (EMG) and provide simultaneous myoelectric control of a virtual 3-DOF wrist/hand system. Performance was compared to the simultaneous control of conventional myoelectric prosthesis methods using intramuscular EMG (parallel dual-site control)-an approach that requires users to independently modulate individual muscles in the residual limb, which can be challenging for amputees. Linear regression control was evaluated in eight able-bodied subjects during a virtual Fitts' law task and was compared to performance of eight subjects using parallel dual-site control. An offline analysis also evaluated how different types of training data affected prediction accuracy of linear regression control. The two control systems demonstrated similar overall performance; however, the linear regression method demonstrated improved performance for targets requiring use of all three DOFs, whereas parallel dual-site control demonstrated improved performance for targets that required use of only one DOF. Subjects using linear regression control could more easily activate multiple DOFs simultaneously, but often experienced unintended movements when trying to isolate individual DOFs. Offline analyses also suggested that the method used to train linear regression systems may influence controllability. Linear regression myoelectric control using intramuscular EMG provided an alternative to parallel dual-site control for 3-DOF simultaneous control at the wrist and hand. The two methods demonstrated different strengths in controllability, highlighting the tradeoff between providing simultaneous control and the ability to isolate individual DOFs when desired.

  10. Sistema Robotizado para el transporte de materiales en el que es importante el control de la orientación

    OpenAIRE

    Lago Rodríguez, Alfonso

    2015-01-01

    El presente proyecto se centra en la elaboración de un sistema que permita el control de la orientación en 3D, en tiempo real, de un manipulador ABB IRB 120. Se trata de programar un robot industrial para el transporte de productos en los que es importante en control de su orientación. Se pretende implementar un control en cadena cerrada, en base a la información sobre la orientación proporcionada en tiempo real por un sensor inercial tipo IMU de la marca Xsens. Se ha implementado un protocol...

  11. Distribution of Neomycin in Bull Calves After Intramuscular Injection

    OpenAIRE

    Black, W. D.; Claxton, M. J.

    1982-01-01

    Neomycin sulfate was injected intramuscularly in calves. Blood and tissue samples were taken at zero, one, two, four, six, eight and 24 hours after administration. The tissues with high levels (greater than 10 μg/g) of drug at the one hour period were kidney cortex and medulla, urine, blood serum and the injection site. By 24 hours after administration only the kidney cortex and urine had high levels of neomycin. The drug could not be detected in any brain tissues and very small amounts (less...

  12. Morphology of local changes following intramuscular application of some radioprotectives

    International Nuclear Information System (INIS)

    Resl, M.; Kuna, P.

    1985-01-01

    The dynamics is described of morphological changes following the intramuscular administration to unirradiated rats of Imuna physiological solution, Aqua pro inj. Biotika, gammaphos of domestic make dissolved in physiological solution or in injection water, cystamine either alone or in combination with mexamine dissolved in physiological solution. The least manifest local changes were found following the application of physiological solution alone, the most significant changes were found after the application of Aqua pro inj. Biotika alone. The comparison showed that the most suitable form of radioprotectives is gammaphos in physiological solution. (author)

  13. APLASIA CUTIS CONGÉNITA – UM CASO CLÍNICO

    Directory of Open Access Journals (Sweden)

    Mónica Costeira

    2016-07-01

    Comentários: A aplasia cutis congénita é uma lesão que pode ser causadora de grande ansiedade parental, pelo que é importante ao Pediatra o seu reconhecimento e devido esclarecimento. Apesar de se tratar, na maioria das vezes, de um defeito benigno, é importante o conhecimento da sua relação com outras anomalias e síndromes de forma a otimizar a sua orientação precoce e adequada. Da mesma forma, é importante o aconselhamento genético, nos casos que assim o justifiquem.

  14. Anatomía quirúrgica del músculo glúteo mayor: espacio Intramuscular de FROD

    Directory of Open Access Journals (Sweden)

    Freddy Rodríguez-García

    Full Text Available Antecedentes y Objetivos. El músculo glúteo mayor es el más voluminoso y superficial de la región glútea, con forma cuadrilátera, dos inserciones diferentes, espesor variable en sus distintas zonas, y cubierto con diferentes fascias o aponeurosis. Realizamos un detallado estudio de la anatomía descriptiva y quirúrgica de dicho músculo para comparar cuál de las técnicas actuales utilizadas para el aumento glúteo con implantes es más segura y cuál proporciona mejores resultados. Material y método. Estudiamos 10 cadáveres frescos facilitados por el Instituto de Medicina Legal Regional Norte, y 10 cadáveres formolizados del anfiteatro de la Universidad Libre Seccional Barranquilla (Colombia, durante el período comprendido entre marzo de 2009 y febrero de 2010. Resultados. Determinamos que el músculo glúteo mayor, además de sus características anatómicas detalladas en los textos de anatomía descriptiva, está constituido por gruesos fascículos musculares paralelos y adyacentes unidos por fuertes tabiques o septos fibroaponeuróticos, del plano superficial al profundo. En el desarrollo del estudio encontramos un espacio anatómico intramuscular en el glúteo mayor, no descrito antes en las publicaciones de Cirugía Plástica ni en los textos de Anatomía más conocidos. Se presenta como una zona limpia, de aproximadamente 10 cm. de diámetro, con delicada aponeurosis muscular en su piso, sin la presencia de los tabiques fibroaponeuróticos interfasciculares habituales y exenta de estructuras vasculonerviosas importantes. Conclusiones. Describimos un nuevo espacio intramuscular en el glúteo mayor, que identificamos como Espacio Intramuscular de FROD, que consideramos de enorme potencial quirúrgico para la ejecución de las técnicas de aumento glúteo.

  15. A representação social de um corpo magro por adolescentes obesas

    OpenAIRE

    Dressiane Zanardi Pereira

    2011-01-01

    Introdução A obesidade entre adolescentes é um problema que afeta a saúde pública como um todo. Pode ser caracterizada como um distúrbio do estado nutricional normal que gera um aumento de tecido adiposo, reflexo do excesso de gordura resultante do balanço energético positivo. É uma doença multifatorial de origem desconhecida com diagnóstico complexo. As ações de saúde direcionadas para os jovens com essa patologia, devem levar em consideração importantes aspectos dessa fase da vida do indiv...

  16. Infiltrative intramuscular myxoma of the cervical spine: a case report.

    Science.gov (United States)

    Manoharan, Sakthivel Rajan Rajaram; Shaw, Andrew B; Arnold, Christina A; Farhadi, H Francis

    2015-01-01

    Myxomas are benign tumors of mesenchymal cell origin that usually present as solitary lesions. They are infrequently associated with fibrous dysplasia, as in McCune-Albright or Mazabraud syndrome. Myxomas can develop in a variety of locations, although the most frequent sites are the thigh, buttocks, shoulder, and upper arm. Intramuscular myxomas (IMs) refer to lesions that occur within muscle compartments. They have been infrequently reported in the neck musculature. To date, only five cases have been reported within the posterior neck muscles without associated intraspinal extension. To our knowledge, this is the first case of an IM presenting with extension into the spinal canal. We report a case of posterior cervical IM with intraspinal extension presenting in a 63-year-old woman as a palpable mass. Complete intralesional resection of the tumor was achieved by standard midline posterior approach. Meticulous resection of the entire capsule was achieved and all margins were confirmed to be free of neoplasm. A diagnosis of myxoma was provided on pathologic evaluation. Follow-up at 1.5 years confirmed maintained complete resolution of the preoperative symptoms, with no evidence of local recurrence on imaging. Intramuscular myxomas should be included in the differential diagnosis of cervical paraspinal tumors. Furthermore, we suggest that masses involving the axial muscles should be closely monitored and the patient counseled regarding potential neurologic sequelae. Copyright © 2015 Elsevier Inc. All rights reserved.

  17. Safety of Moxifloxacin following repeated intramuscular administration in Wistar rats

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    K.A. Sadariya

    Full Text Available Moxifloxacin is a novel fourth generation fluoroquinolone with broad spectrum of antibacterial activity. The study was conducted to evaluate the safety of Moxifloxacin (5.0 mg/kg after repeated intramuscular administration at 24 h interval for 14 days in male and female wistar rats. Hematological (Haemoglobin, RBC, WBC, MCV, MCH, MCHC, HCT and DLC, blood biochemical parameters (AST, ALT, ALP, Total Bilirubin, Total Serum Protein, Serum Albumin, Globulin, Serum Creatinine, Urea, Uric acid and Blood glucose and histopathological examination of various tissues were carried out in the present study. Male and female animals of any group did not reveal any clinical symptoms and mortality attributable to the 14 days intramuscular administration of Moxifloxacin. The data were compared by unpaired two tail `t` test using Graph Pad Prism (Version 4.00. All above hematological and blood biochemical parameters were found to fluctuate within normal range during treatment period and the mean values were not significantly differ (p < 0.05 from corresponding control values. Moreover, no gross or microscopic changes were found in the liver, kidney, heart, spleen, stomach, intestine and joint cartilages of the treated wistar rats. Results indicate that daily administration of Moxifloxacin for 14 days seems to be safe and well tolerated in rats. [Veterinary World 2010; 3(10.000: 449-452

  18. Intramuscular vascular malformations of an extremity: findings on MR imaging and pathologic correlation

    International Nuclear Information System (INIS)

    Kim, E.Y.; Ahn, J.M.; Yoon, H.K.; Do, Y.S.; Kim, S.H.; Choo, S.W.; Choo, I.W.; Suh, Y.L.; Kim, S.M.; Kang, H.S.

    1999-01-01

    Objective. To analyze the findings of intramuscular vascular malformations of an extremity on MR imaging and to correlate these findings with histopathologic examination.Design and patients. The findings on MR imaging and the medical records of 14 patients with an intramuscular vascular malformation of the extremity were retrospectively studied. All patients underwent surgical excision. Diagnoses were based on the results of pathologic examination. Findings on MR imaging were noted and correlated with the histopathologic findings.Results. Intramuscular vascular malformations of an extremity showed multi-septate, honeycomb, or mixed appearance on MR imaging. Multi-septate areas correlated with dilated and communicating vascular spaces with flattened endothelium. Honeycomb areas corresponded to vascular spaces with inconspicuous small lumina and thickened vascular walls. Areas of increased signal intensity on T2-weighted images were found in all intramuscular vascular malformations. Infiltrative margins were more commonly seen in intramuscular lymphaticovenous malformations. Adherence to neurovascular structures and orientation of the lesion along the long axis of the affected muscle were more commonly seen in intramuscular venous malformations.Conclusions. Intramuscular vascular malformations showed either a multi-septate, honeycomb, or mixed appearance, reflecting the size of the vascular spaces and the thickness of the smooth muscles of the vessel walls. Prediction of the subtype of an intramuscular vascular malformation of an extremity on MR imaging seems to be difficult, although there are associated findings that may be helpful in the differential diagnosis of each subtype. (orig.)

  19. Health worker and policy-maker perspectives on use of intramuscular artesunate for pre-referral and definitive treatment of severe malaria at health posts in Ethiopia

    OpenAIRE

    Kefyalew, Takele; Kebede, Zelalem; Getachew, Dawit; Mukanga, David; Awano, Tessema; Tekalegne, Agonafer; Batisso, Esey; Edossa, Wasihun; Mekonnen, Emebet; Tibenderana, James; Baba, Ebenezer Sheshi; Shumba, Constance; Nankabirwa, Joaniter I.; Hamade, Prudence

    2016-01-01

    Abstract Background The World Health Organization (WHO) recommends injectable artesunate given either intravenously or by the intramuscular route for definitive treatment for severe malaria and recommends a single intramuscular dose of intramuscular artesunate or intramuscular artemether or intramuscular quinine, in that order of preference as pre-referral treatment when definitive treatment is not possible. Where intramuscular injections are not available, children under 6 years may be admin...

  20. Avaliando a comutatividade: importante requisito da qualidade para laboratórios clínicos Understanding commutability: important quality requirement for clinical laboratories

    Directory of Open Access Journals (Sweden)

    Chams Bicalho Maluf

    2011-12-01

    Full Text Available INTRODUÇÃO: Poucos laboratórios no Brasil realizam a avaliação da comutatividade dos resultados de exames, provavelmente por desconhecimento dos procedimentos para sua realização e também pela pouca importância dada a essa avaliação. OBJETIVO: Avaliar a comutatividade dos resultados de exames hematológicos realizados em três analisadores automatizados em um laboratório de um hospital público universitário, em Belo Horizonte, MG, Brasil, propondo procedimento prático, de baixa complexidade, factível de ser utilizado em laboratórios clínicos. MATERIAL E MÉTODOS: As amostras foram selecionadas visando obter valores nos níveis de decisão terapêutica. Foram processadas seis amostras por dia, durante quatro dias, em duplicata em três analisadores, totalizando 48 replicatas em cada instrumento. Foi avaliada a correlação entre os resultados de 10 dos principais parâmetros hematológicos obtidos nos instrumentos-teste e aqueles obtidos com o instrumento-referência. Foram estimados os erros sistemáticos e totais, considerando as especificações da variação biológica como limite máximo aceitável. RESULTADOS: O coeficiente de correlação (r entre os equipamentos para os parâmetros investigados foi > 0,975. Os erros sistemático (médio e total, obtidos para os parâmetros analisados, quando se comparam os equipamentos de teste com o de referência, atenderam às especificações da qualidade definidos. Discussão: A comutatividade é um importante processo da gestão da qualidade do laboratório clínico e visa garantir a comparabilidade de resultados de exames realizados por diferentes sistemas. CONCLUSÃO: Utilizando procedimento padronizado internacionalmente, prático e de baixa complexidade, demonstrou-se que os exames realizados nos equipamentos avaliados são equivalentes, podendo ser usados indistintamente no acompanhamento de pacientes.INTRODUCTION: Few Brazilian laboratories evaluate the commutability of test

  1. Discontinuing the Use of PRN Intramuscular Medication for Agitation in an Acute Psychiatric Hospital.

    Science.gov (United States)

    Hayes, Ariel; Russ, Mark J

    2016-03-01

    This study examined the impact of eliminating intramuscular PRN medication for agitation on patient and staff safety in an acute psychiatric inpatient setting. The current retrospective chart review investigated the use of PRN medications (oral and intramuscular) to treat acute agitation, including aggression, and related outcomes before and after a mandated change in PRN practice that required real time physician input before administration of intramuscular medications. The use of both oral and intramuscular PRN medications dramatically decreased following implementation of the mandated change in practice. In particular, the use of intramuscular PRNs for agitation decreased by about half. Despite this decrease, the assault rate in the hospital was unchanged, and the utilization of restraint and seclusion continued to decrease. It is possible to reduce the utilization of PRN medications for agitation without broadly compromising safety on acute care psychiatric inpatient units.

  2. RNA-seq analysis of bovine intramuscular, subcutaneous and perirenal adipose tissues.

    Science.gov (United States)

    Sheng, Xihui; Ni, Hemin; Liu, Yunhai; Li, Junya; Zhang, Lupei; Guo, Yong

    2014-03-01

    The deposition of intramuscular fat is an important factor affecting the beef quality, such as flavour and palatability. In this study, for further identifying the differential molecular mechanisms regulating the deposition of fat between intramuscular and external adipose tissues, particularly subcutaneous and perirenal adipose tissues, it was designed to obtain transcript sequence data and compare the transcriptomes among intramuscular, subcutaneous, and perirenal adipose tissues by RNA-Seq. A total of 66,206,912, 55,114,070 and 67,320,426 fragments were sequenced for the intramuscular (IAT), subcutaneous (SAT), and perirenal adipose tissue (PAT) respectively. Among them, total 953, 1,534, 2,026 genes showing differential expression between IAT and SAT, IAT and PAT, SAT and PAT, were identified respectively (FDR fat deposition, especially intramuscular fat, at a fine scale.

  3. Administração de medicamentos injetáveis por via intramuscular: conhecimento dos ocupacionais de farmácias Administration of intramuscular injections medications: knowledge of occupationals working in pharmacies

    Directory of Open Access Journals (Sweden)

    Silvia Mara Rangel

    2000-06-01

    Full Text Available Complicações advindas da aplicação incorreta das injeções intramusculares podem acarretar sérios prejuízos orgânicos, favorecer o aparecimento de infecções e aumentar a permanência do paciente na instituição ou prejudicar as funções no trabalho. Estudo anterior detectou vários casos de pacientes com complicações locais após aplicação intramuscular de diclofenaco sódico em farmácias e concluiu que a falta de conhecimento da técnica de administração desse medicamento pode ter sido uma das causas das complicações. Diante disso o estudo atual teve o objetivo de identificar e avaliar o nível de conhecimentos de ocupacionais que administram medicamentos injetáveis intramusculares à população, em farmácias de Ribeirão Preto - SP. O estudo se constituiu num levantamento, a partir de um questionário contendo 20 questões abertas e fechadas, aplicado a uma população constituída por ocupacionais atuando em farmácias, selecionadas através do método da amostragem simples casual estratificada -partilha proporcional, resultando num total de 41 sujeitos. Concluímos que a população vem recebendo medicamento s injetáveis de ocupacionais com déficit de informações a respeito da técnica de aplicação de injetáveis. Os sujeitos referiram não receber treinamento adequado para exercer esse procedimento, terminando por aprendê-lo com outro funcionário ou observando alguém que o realize. Disto resulta lacunas de conhecimento em uma amostra de ocupacionais que podem, realmente, levar ao aparecimento de complicações pós injeções intramusculares na população que utiliza os serviços desses estabelecimentos.Complications from the incorrect administration of intramuscular injections can cause serious organic damages, infections and increase the patient's permanence in health institution or to harm the functions in the work. The previous study detected several cases of patients with local complications after

  4. Event sequencing of forced intramuscular medication in England.

    Science.gov (United States)

    Bowers, L; Ross, J; Owiti, J; Baker, J; Adams, C; Stewart, D

    2012-11-01

    In most inpatient psychiatric care systems it is permissible in certain situations for staff to forcibly inject patients with psychotropic medication. The aim of this study is to describe what precedes and follows a coerced intramuscular injection within a nursing shift. Data were collected on the sequence of conflict (aggression, absconding, etc.) and containment (seclusion, restraint, etc.) for the first 2 weeks of 522 acute admissions on 84 wards in 31 UK hospitals. Injections were given to 9% of patients. Aggression, regular medication refusal and pro re nata (PRN) medication refusal preceded injections. The giving of coerced medication concluded most crises. Coerced medication effectively resolves crises in the short term. Staff should offer oral PRN as an alternative, unless this is unsafe. Where only verbal violence has occurred staff should try to resolve the crisis without enforcing medication. More research on the best way to respond to inpatients' medication refusal is required. © 2012 Blackwell Publishing.

  5. Putative regulatory factors associated with intramuscular fat content.

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    Aline S M Cesar

    Full Text Available Intramuscular fat (IMF content is related to insulin resistance, which is an important prediction factor for disorders, such as cardiovascular disease, obesity and type 2 diabetes in human. At the same time, it is an economically important trait, which influences the sensorial and nutritional value of meat. The deposition of IMF is influenced by many factors such as sex, age, nutrition, and genetics. In this study Nellore steers (Bos taurus indicus subspecies were used to better understand the molecular mechanisms involved in IMF content. This was accomplished by identifying differentially expressed genes (DEG, biological pathways and putative regulatory factors. Animals included in this study had extreme genomic estimated breeding value (GEBV for IMF. RNA-seq analysis, gene set enrichment analysis (GSEA and co-expression network methods, such as partial correlation coefficient with information theory (PCIT, regulatory impact factor (RIF and phenotypic impact factor (PIF were utilized to better understand intramuscular adipogenesis. A total of 16,101 genes were analyzed in both groups (high (H and low (L GEBV and 77 DEG (FDR 10% were identified between the two groups. Pathway Studio software identified 13 significantly over-represented pathways, functional classes and small molecule signaling pathways within the DEG list. PCIT analyses identified genes with a difference in the number of gene-gene correlations between H and L group and detected putative regulatory factors involved in IMF content. Candidate genes identified by PCIT include: ANKRD26, HOXC5 and PPAPDC2. RIF and PIF analyses identified several candidate genes: GLI2 and IGF2 (RIF1, MPC1 and UBL5 (RIF2 and a host of small RNAs, including miR-1281 (PIF. These findings contribute to a better understanding of the molecular mechanisms that underlie fat content and energy balance in muscle and provide important information for the production of healthier beef for human consumption.

  6. Efficacy of intramuscular and intraperitoneal deferoxamine for aluminum chelation.

    Science.gov (United States)

    Molitoris, B A; Alfrey, P S; Miller, N L; Hasbargen, J A; Kaehney, W D; Alfrey, A C; Smith, B J

    1987-04-01

    As intravenous administration of deferoxamine is difficult in home dialysis patients we set out to determine the efficacy of intramuscular (i.m.) and intraperitoneal (i.p.) deferoxamine for removal of aluminum. Patients with serum aluminum levels greater than 90 micrograms/liter were studied in a paired fashion with each patient serving as their own control. Serum and peritoneal fluid aluminum were determined using flameless atomic absorption. In hemodialysis patients 2 g of intravenous deferoxamine increased serum aluminum from 124.7 +/- 32.4 to 415 +/- 192.4 micrograms/liter. One g of deferoxamine given intravenously or intramuscularly resulted in 76.8 +/- 35.3% and 70.4 +/- 23.2%, respectively, of the 2 g i.v. response. The rate at which serum aluminum increased following i.v. deferoxamine infusion was biphasic, with an initial rapid phase lasting 139 minutes followed by a much slower phase. The volume of distribution of aluminum following deferoxamine administration was 12.6 +/- 1.61 and the half life (t1/2) for aluminum removal during hemodialysis was 9.0 +/- 2.0 hours. The increase in serum aluminum following deferoxamine was not due to chelation of erythrocyte aluminum as erythrocyte aluminum remained constant over 24 hours. In patients on continuous ambulatory peritoneal dialysis, 2 g intravenous deferoxamine resulted in the removal of 560 +/- 267 micrograms of aluminum over 24 hours while 2 g deferoxamine given intraperitoneally gave 91 +/- 13% of the intravenous response. Aluminum clearance over 48 hours was twice that for 24 hours for both i.v. and i.p. deferoxamine.(ABSTRACT TRUNCATED AT 250 WORDS)

  7. BOLSA FAMÍLIA: IMPORTANTE DETERMINANTE PARA A EDUCAÇÃO E CRESCIMENTO SOCIOECONÔMICO DO BRASIL

    OpenAIRE

    Ferreira, Luiz Antonio

    2012-01-01

    Esta dissertação trata de um tema relativamente novo, com literatura escassa, praticamente sem estudos teóricos que o abordem. Referenciais são encontrados em publicações feitas em seminários e palestras bem como em artigos e notas jornalísticas. Esta dissertação se trata de trabalho exploratório, analítico descritivo com base documental. O Programa Bolsa Família, tema central deste trabalho, é uma ferramenta para distribuição de renda que funciona de forma simples e tem sido efetiva para o a...

  8. Bloqueio do nervo supraescapular: procedimento importante na prática clínica. Parte II

    OpenAIRE

    Fernandes,Marcos Rassi; Barbosa,Maria Alves; Sousa,Ana Luiza Lima; Ramos,Gilson Cassem

    2012-01-01

    O bloqueio do nervo supraescapular é um método de tratamento reprodutível, confiável e extremamente efetivo no controle da dor no ombro. Esse método tem sido amplamente utilizado por profissionais na prática clínica, como reumatologistas, ortopedistas, neurologistas e especialistas em dor, na terapêutica de enfermidades crônicas, como lesão irreparável do manguito rotador, artrite reumatoide, sequelas de AVC e capsulite adesiva, o que justifica a presente revisão (Parte II). O objetivo deste ...

  9. Lealdade a um acordo estabelecido entre os escolares

    Directory of Open Access Journals (Sweden)

    Nelson Pedro-Silva

    Full Text Available Resumo Com o presente estudo objetivamos saber se os alunos consideravam a lealdade um valor mais importante do que a honestidade e a veracidade. O universo pesquisado foi composto de 40 estudantes matriculados no Ensino Fundamental II de uma cidade do interior paulista. Para a coleta de informações, empregamos duas historietas sobre a lealdade, que serviram de ponto de partida para a entrevista, segundo o modelo piagetiano. Os resultados apontaram os seguintes aspectos: a a lealdade, para ser concebida como valor, não depende do conteúdo, mas das consequências geradoras a outrem; b ela parece ser independente da experiência escolar; e c as meninas se inclinam a ver, mais do que os meninos, a lealdade a um acordo estabelecido como um valor, apesar de condenarem seu conteúdo e serem mais sensíveis aos seus resultados. Concluímos que, a despeito dos resultados, a lealdade deve ser concebida como um valor importante para os estudantes.

  10. INFLUENCE OF GENETIC POLYMORPHISM IN FABP3 AND LEPR GENES ON INTRAMUSCULAR FAT CONTENT IN PIG CARCASSES

    Directory of Open Access Journals (Sweden)

    Kristina Budimir

    2014-06-01

    Full Text Available Intensive production conditions, selection directed to increase the percentage of muscle tissue in carcasses and consumer demand have led to a reduction of intramuscular fat content in pig carcasses. Intramuscular fat is a factor affecting the flavor, juiciness and tenderness of pork meat. FABP protein family causes the differences in the content of intramuscular fat in different pig breeds. FABP3 and LEPR gene are candidate genes for intramuscular fat content and their polymorphisms explain the variability that can occur in different pig breeds. The aim of this paper is to demonstrate the influence of genes on different intramuscular fat content in pig carcasses due to pigs genotype.

  11. Extended-release intramuscular paliperidone palmitate: a review of its use in the treatment of schizophrenia.

    Science.gov (United States)

    Carter, Natalie J

    2012-05-28

    Extended-release intramuscular paliperidone palmitate (Xeplion®; Invega® Sustenna®) [henceforth referred to as intramuscular paliperidone palmitate] is a long-acting injectable (LAI) formulation of the well established atypical antipsychotic agent paliperidone (9-hydroxyrisperidone), which is the major active metabolite of risperidone. This article reviews, from an EU perspective, the therapeutic efficacy and tolerability of intramuscular paliperidone palmitate in the treatment of adults with schizophrenia, and the pharmacology of paliperidone that is relevant to the intramuscular formulation. Intramuscular paliperidone palmitate 25-150 mg equivalents (mg eq.) effectively reduced symptoms of schizophrenia in most short-term (9-13 weeks) placebo-controlled trials, as demonstrated by improvements in Positive and Negative Syndrome Scale (PANSS) total scores from baseline to endpoint that were significantly greater in intramuscular paliperidone palmitate than placebo recipients. The onset of clinical response was 8 days in patients who received the recommended initial 150 mg eq. dose of intramuscular paliperidone palmitate into the deltoid muscle on day 1. In a longer-term (24-week maintenance phase and variable length double-blind phase) placebo-controlled trial, intramuscular paliperidone palmitate was associated with a significantly longer time to relapse than placebo in patients with schizophrenia at a preplanned interim analysis conducted after 68 relapse events. Because of these favourable results, the study was terminated early. In two 13-week trials, one of which was conducted in Chinese patients, intramuscular paliperidone palmitate administered using the recommended initiation dosage regimen was noninferior to LAI-risperidone in patients with schizophrenia in terms of the between-group treatment difference (intramuscular paliperidone palmitate vs LAI-risperidone) for the mean change from baseline to endpoint in PANSS total score. The tolerability of

  12. Livedoid dermatitis and severe necrosis (Nicolau's syndrome) after intramuscular hydroxyzine injection.

    Science.gov (United States)

    Gayken, Jon; Westanmo, Anders; Knutsen, Amy; Ahrenholz, David H; Mohr, William J; Solem, Lynn D

    2006-01-01

    Nicolau's syndrome, also called embolica cutis medicamentosa, is characterized by well- circumscribed livedoid dermatitis with aseptic necrosis after intramuscular injection. We report the case of a 45-year-old woman with severe necrosis of the thigh several days after a routine intramuscular injection of hydroxyzine who was transferred to and treated at our Regional Burn Center. Although there has been one case report and numerous voluntarily reported instances of intramuscular hydroxyzine-induced necrosis to the Food and Drug Administration Spontaneous Reporting System, this phenomenon is rare.

  13. A contabilidade como ferramenta importante para o planejamento tributário das micro e empresas de pequeno porte

    Directory of Open Access Journals (Sweden)

    Jádson Gonçalves Ricarte

    2005-11-01

    Full Text Available Existem problemas com melhores ou piores soluções, assim como existem pessoas com maior ou menor capacidade para solução de problemas. Portanto, ao idealizar um estudo, um dos principais pré-requisitos que motiva o pesquisador é abordá-lo de forma tal que possa vir a atingir tanto os que dominam ou tem interesses já específicos por ele, por exemplo, a comunidade acadêmica, como também aqueles que não apresentam o conhecimento, muito menos o interesse, pois muitas vezes estão além de suas diretrizes de curto prazo. As microempresas e as empresas de pequeno porte (EPPs representam 99,20% das empresas constituídas no Brasil, sendo 87,95% de micro empresas e 11,25% de pequenas empresas, empregando 56, 1 0% da mão-de-obra disponível. No nordeste as empresas de pequeno porte constituem um total de aproximadamente 540.000, o que representa 78,74% de todas as empresas em funcionamento nesta região. A finalidade deste trabalho é fazer um comparativo da forma de tributação entre as microempresas, as empresas de pequeno porte e as demais empresas, que nós, no Brasil, as classificamos como empresas normais, pois não se utilizam de qualquer benefício fiscal, demonstrando a melhor opção de tributação para o micro e pequeno empresário. There are some issues that have better ofworse solutions. ln the same way,there are people with higher or less capacity to solve problems. 50, whenidealizing study, one of the main pre-requirements that motivates theresearcher is to develop it in such way that is going to affect the ones whoknows it or ahs interests already specified before for instance the academiccommunity as those who do not show knowledge, nor even interest, becausethey are beyond their short-term aims. Micro and small companies (EPPsrepresent 99,20% ofthe companies built in Brazil, composed by 87,95% ofmicro companies and 11,25% ofsmall companies, employing 56, 10% oftheavailable workers. ln the northeast the small companies are

  14. CONFIANÇA: UM CONSTRUTO UNIVERSAL

    Directory of Open Access Journals (Sweden)

    Breno Augusto Diniz

    2011-09-01

    Full Text Available A confiança cumpre um importante papel nos relacionamentos interorganizacionais e interpessoais. Este artigo explora, através de pesquisa bibliográfica, o papel da confiança em cinco diferentes teorias organizacionais e sociais: a teoria dos custos de transação, a teoria da agência, a teoria dos recursos internos, do capital social e a teoria transitiva (através do pensamento da americana Mary Parker Follet, buscando melhor compreender sua função em cada uma delas. Verificaram-se algumas correlações substanciais entre tais teorias no que tange à confiança.

  15. La adaptación de los alumnos inmigrantes: factores importantes para la educación

    Directory of Open Access Journals (Sweden)

    Jacqueline Graff Munaro

    2014-04-01

    Full Text Available http://dx.doi.org/10.5007/2175-795X.2014v32n1p237 Este estudio analiza la integración de los alumnos inmigrantes, en España, así como las actitudes hacia la inmigración de los alumnos españoles, en relación con variables psicosociales. El objetivo principal fue describir el proceso adaptativo e identificar variables que puedan servir para la acción educativa. El marco teórico de la aculturación y la identidad étnica es de Berry. Se realizó un estudio descriptivo y correlacional con una metodología cuantitativa y cualitativa. Los participantes eran adolescentes de 12 Institutos de la provincia de Salamanca repartidos en dos muestras: 516 autóctonos y 73 inmigrantes procedentes de América Latina, Europa, África del Norte y Central, y de Oriente (Total: 589. Se realizaron entrevistas (inmigrantes y cuestionarios para ambas muestras. Se utilizó la comparación de medias para analizar las muestras de españoles e inmigrantes por separado y después conjuntamente con las variables comunes. Se hizo un análisis de contenido de las entrevistas para conocer la apreciación del nuevo país y sus expectativas de futuro. Los resultados han demostrado que la integración es mayoritaria, pese a la discriminación. Las actitudes de los españoles hacia la inmigración fueron favorables. Estos factores están relacionados con variables psicosociales importantes para la actuación educativa: la empatía, el clima de clase, la importancia percibida de contacto y la autoestima.

  16. ¿Qué es la CIE y por qué es importante en la psicología?

    Directory of Open Access Journals (Sweden)

    Geoffrey M. Reed

    2012-01-01

    Full Text Available La Clasificación Internacional de las Enfermedades (CIE de la Organización Mundial de Salud (OMS es muy poco conocida en el ámbito de la psicología en España, y existe la falsa percepción de que su importancia es escasa en el campo de la salud mental. El propósito de este artículo es familiarizar a los psicólogos y otros profesionales en salud mental con el sistema de clasificación CIE, algo especialmente relevante al encontrarse actualmente en proceso de revisión. La OMS está haciendo un gran esfuerzo para crear una clasificación de trastornos mentales global, multicultural y multidisciplinar, centrándose en mejorar su utilidad clínica. Además, en la actual revisión de la CIE, la OMS ha adoptado el español como segunda lengua de trabajo, lo que da una gran oportunidad a los profesionales de la salud mental de España y otros países hispanohablantes de implicarse activamente en el desarrollo de la próxima versión de la clasificación. Es importante que los psicólogos de países hispanohablantes conozcan la CIE y entiendan los grandes beneficios que pueden aportarles su conocimiento y utilización para integrarse plenamente como profesión sanitaria oficial, así como para equipararse en la práctica de la psicología al resto de Europa y de todo el mundo en términos de diagnóstico y clasificación de los trastornos mentales.

  17. Polyphenol supplementation alters intramuscular apoptotic signaling following acute resistance exercise.

    Science.gov (United States)

    Townsend, Jeremy R; Stout, Jeffrey R; Jajtner, Adam R; Church, David D; Beyer, Kyle S; Riffe, Joshua J; Muddle, Tyler W D; Herrlinger, Kelli L; Fukuda, David H; Hoffman, Jay R

    2018-01-01

    The purpose of this study was to examine the effects of 28-days of supplementation with an aqueous proprietary polyphenol blend (PPB) sourced from Camellia sinensis on intramuscular apoptotic signaling following an acute lower-body resistance exercise protocol and subsequent recovery. Untrained males (n = 38, 21.8 ± 2.7 years, 173.4 ± 7.9 cm, 77.6 ± 14.6 kg) were randomized to PPB (n = 14), placebo (PL; n = 14) or control (CON; n = 10). Participants completed a lower-body resistance exercise protocol comprised of the squat, leg press, and leg extension exercises. Skeletal muscle microbiopsies were obtained from the vastus lateralis preexercise (PRE), 1-h (1HR), 5-h (5HR), and 48-h (48HR) post-resistance exercise. Apoptotic signaling pathways were quantified using multiplex signaling assay kits to quantify total proteins (Caspase 3, 8, 9) and markers of phosphorylation status (JNK, FADD, p53, BAD, Bcl-2). Changes in markers of muscle damage and intramuscular signaling were analyzed via separate repeated measures analysis of variance (ANOVA). Change in Bcl-2 phosphorylation at 1H was significantly greater in PL compared to CON (P = 0.001). BAD phosphorylation was significantly elevated at 5H in PL compared to PPB (P = 0.015) and CON (P = 0.006). The change in JNK phosphorylation was significantly greater in PPB (P = 0.009), and PL (P = 0.017) compared to CON at 1H, while the change for PL was elevated compared to CON at 5H (P = 0.002). A main effect was observed (P < 0.05) at 1H, 5H, and 48H for p53 and Caspase 8, with Caspase 3 and Caspase 9 elevated at 48H. These data indicate that chronic supplementation with PPB alters apoptotic signaling in skeletal muscle following acute muscle-damaging resistance exercise. © 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

  18. Subcutaneous or intramuscular injections of insulin in children. Are we injecting where we think we are?

    Science.gov (United States)

    Polak, M; Beregszaszi, M; Belarbi, N; Benali, K; Hassan, M; Czernichow, P; Tubiana-Rufi, N

    1996-12-01

    This study was designed to assess the insulin injection location in a group of children who had their injection according to their daily practice, thought to lead to subcutaneous injections. The location of the insulin deposit at the injection site was visualized using an ultrasound device. The exact insulin injection location could be localized, and 18 of 59 injections (30.5%) (one injection for each child) were in the intramuscular tissue. Of the children who had intramuscular injection, 15 of 18 were boys. The children who had an intramuscular injection had a significantly lower percentile of BMI (mean +/- SE: 47 +/- 8 vs. 72 +/- 4, P = 0.004), lower distance from skin surface to muscle fascia without a skinfold (5.6 +/- 0.6 vs. 11 +/- 0.7 mm, P insulin injection. We identified a group of children at risk for intramuscular insulin injections and that may deserve specific injection technique and advice.

  19. Pharmacokinetic Studies of Intramuscular Midazolam in Guinea Pigs Challenged With Soman

    National Research Council Canada - National Science Library

    Capacio, Benedict R; Byers, C. E; Merk, K. A; Smith, J. R; McDonough, J. H

    2004-01-01

    ...) activity following intramuscular (im) injection to soman-exposed guinea pigs (Crl:(HA)BR). Prior to experiments, the animals were surgically implanted with EEG leads to monitor seizure activity...

  20. The IDvIP Trial: A two-centre randomised double-blind controlled trial comparing intramuscular diamorphine and intramuscular pethidine for labour analgesia

    Directory of Open Access Journals (Sweden)

    Thomas Peter

    2011-07-01

    Full Text Available Abstract Background Intramuscular pethidine is routinely used throughout the UK for labour analgesia. Studies have suggested that pethidine provides little pain relief in labour and has a number of side effects affecting mother and neonate. It can cause nausea, vomiting and dysphoria in mothers and can cause reduced fetal heart rate variability and accelerations. Neonatal effects include respiratory depression and impaired feeding. There are few large studies comparing the relative side effects and efficacy of different opioids in labour. A small trial comparing intramuscular pethidine with diamorphine, showed diamorphine to have some benefits over pethidine when used for labour analgesia but the study did not investigate the adverse effects of either opioid. Methods The Intramuscular Diamorphine versus Intramuscular Pethidine (IDvIP trial is a randomised double-blind two centre controlled trial comparing intramuscular diamorphine and pethidine regarding their analgesic efficacy in labour and their side effects in mother, fetus and neonate. Information about the trial will be provided to women in the antenatal period or in early labour. Consent and recruitment to the trial will be obtained when the mother requests opioid analgesia. The sample size requirement is 406 women with data on primary outcomes. The maternal primary outcomes are pain relief during the first 3 hours after trial analgesia and specifically pain relief after 60 minutes. The neonatal primary outcomes are need for resuscitation and Apgar Score Discussion If the trial demonstrates that diamorphine provides better analgesia with fewer side effects in mother and neonate this could lead to a change in national practice and result in diamorphine becoming the preferred intramuscular opioid for analgesia in labour. Trial Registration ISRCTN14898678 Eudra No: 2006-003250-18, REC Reference No: 06/Q1702/95, MHRA Authorisation No: 1443/0001/001-0001, NIHR UKCRN reference 6895, RfPB grant

  1. Efficacy and Tolerability of Intramuscular Dexketoprofen in Postoperative Pain Management following Hernia Repair Surgery

    OpenAIRE

    Jamdade, P. T.; Porwal, A.; Shinde, J. V.; Erram, S. S.; Kamat, V. V.; Karmarkar, P. S.; Bhagtani, K.; Dhorepatil, S.; Irpatgire, R.; Bhagat, H.; Kolte, S. S.; Shirure, P. A.

    2011-01-01

    Objective. To evaluate the safety and efficacy of intramuscular dexketoprofen for postoperative pain in patients undergoing hernia surgery. Methodology. Total 202 patients received single intramuscular injection of dexketoprofen 50 mg or diclofenac 50 mg postoperatively. The pain intensity (PI) was self-evaluated by patients on VAS at baseline 1, 2, 4, 6, and 8 hours. The efficacy parameters were number of responders, difference in PI (PID) at 8 hours, sum of analogue of pain intensity differ...

  2. Pharmacokinetics of florfenicol after intravenous and intramuscular dosing in llamas.

    Science.gov (United States)

    Pentecost, Rebecca L; Niehaus, Andrew J; Werle, Nick A; Lakritz, Jeffrey

    2013-10-01

    Florfenicol, is a broad spectrum antimicrobial agent with wide tissue distribution commonly used to treat camelids. To address the lack of drug disposition data for florfenicol in llamas, we evaluated the pharmacokinetics after 20mg/kg intravenous (i.v.) and intramuscular (i.m.) dosing. Serum concentrations were determined using a HPLC-UV assay and pharmacokinetic analysis was conducted using non-compartmental analysis. Following i.v. injection, systemic clearance and Vdss in llamas were 4.6 mL/min/kg and 737 mL/kg, respectively. Mean residence time after i.v. dosing was 3h. After i.m. injection, florfenicol was rapidly absorbed, with Cmax concentrations being 3.2 μg/mL at 0.5h, mean residence time was 15 h, mean absorption time was 12h and absolute bioavailability of florfenicol after i.m. injection was 63%. The prolonged absorption of florfenicol after i.m. administration suggests the apparent HL_λz reflects the absorption process rather than elimination of the drug. Florfenicol administration was not associated with adverse reactions after dosing by either route. Serum florfenicol concentrations remained >1.0 μg/mL for 12h after i.m. administration. For susceptible pathogens, once daily dosing of 20mg/kg body weight appears appropriate. Copyright © 2013 Elsevier Ltd. All rights reserved.

  3. Intramuscular ketamine to facilitate pediatric central vascular access.

    Science.gov (United States)

    Denmark, T Kent; Hargrove, Jenny R; Brown, Lance

    2004-07-01

    Obtaining prompt vascular access in young children presenting to the emergency department (ED) is frequently both necessary and technically challenging. The objective of our study was to describe our experience using intramuscular (IM) ketamine to facilitate the placement of central venous catheters in children presenting to our ED needing vascular access in a timely fashion. We performed a retrospective medical record review of all pediatric patients central venous catheter facilitated by the use of IM ketamine. Eleven children met our inclusion criteria. Most of the children were young and medically complicated. The children ranged in age from 6 months to 8 years. The only complication identified was vomiting experienced by an 8-year-old boy. Emergency physicians successfully obtained central venous access in all subjects in the case series. The use of IM ketamine to facilitate the placement of central venous catheters in children who do not have peripheral venous access appears to be helpful. Emergency physicians may find it useful to be familiar with this use of IM ketamine.

  4. Development and assessment of learning objects about intramuscular medication administration

    Directory of Open Access Journals (Sweden)

    Lilian Mayumi Chinen Tamashiro

    2014-10-01

    Full Text Available OBJECTIVES: to develop and assess a learning object about intramuscular medication administration for nursing undergraduates and nurses.METHOD: a random, intentional and non-probabilistic sample was selected of nurses from a Brazilian social network of nursing and students from the Undergraduate Program at the University of São Paulo School of Nursing to serve as research subjects and assess the object.RESULTS: the participants, 8 nurses and 8 students, studied the object and answered an assessment instrument that included the following criteria: educational aspects (relevance of the theme, objectives and texts/hypertexts, interface of the environment (navigation, accessibility and screen design and didactic resources (interactivity and presentation of resources. In total, 128 significant answers were obtained, 124 (97% of which were positive, assessed as excellent and satisfactory, considered as a flexible, dynamic, objective resources that is appropriate to the nursing learning process.CONCLUSION: the educational technology shows a clear and easily understandable language and the teaching method could be applied in other themes, contributing to the education and training of nursing professionals, positively affecting nursing teaching, stimulating the knowledge, autonomous and independent learning, aligned with the new professional education requirements.

  5. Intramuscular myxoma: clinical and surgical observation notes on eleven cases.

    Science.gov (United States)

    Baltu, Yahya; Arikan, Şefik Murat; Dölen, Utku Can; Uzun, Hakan; Alkan, Banu İnce; Aydın, Orhan

    2017-04-01

    Intramuscular myxoma (IM) is a benign, soft tissue neoplasm of mesenchymal origin. We report our experience with this tumour. This clinical study comprised 11 cases of IM that were operated on between March 2008 and June 2016. Tumour location and size, results of pre-operative radiological studies, preop-erative biopsies, pathology examinations, applied surgical method and post-operative complications were reported for all patients. In total, nine patients with 11 IMs with a mean age of 60.0 years were assessed. Mean follow-up was 39.2 months. Tumours were located in the right thigh (5 patients, 7 IM), left gluteal area (2 patients, 2 IM), right gluteal area (1 IM) and left thigh (1 IM) ranging from 2 × 1 cm to 10 × 17 cm Pre-operative radiological diagnoses were cystic lesion, abscess, bursitis, fibrosarcoma, fibroma, lipoma, malign mesenchymal tumour and IM. Pre-operative biopsy was performed for five cases. All tumours were removed via simple excision and were pathologically consistent with IM. No complication or recurrence was observed during the follow-up period. IM is a relatively rare benign tumour, the pre-operative diagnosis of which using radiological and clinical methods is quite difficult, creating pre-operative diagnostic confusion. It is generally diagnosed by microscopic examination. Simple excision with a small margin of surrounding tissue is considered to be sufficient for its treatment.

  6. Pharmacokinetics of intravenous and intramuscular buprenorphine in the horse.

    Science.gov (United States)

    Davis, J L; Messenger, K M; LaFevers, D H; Barlow, B M; Posner, L P

    2012-02-01

    The purpose of this study was to determine the pharmacokinetics of buprenorphine following intravenous (i.v.) and intramuscular (i.m.) administration in horses. Six horses received i.v. or i.m. buprenorphine (0.005 mg/kg) in a randomized, crossover design. Plasma samples were collected at predetermined times and horses were monitored for adverse reactions. Buprenorphine concentrations were measured using ultra-performance liquid chromatography with electrospray ionization mass spectrometry. Following i.v. administration, clearance was 7.97±5.16 mL/kg/min, and half-life (T(1/2)) was 3.58 h (harmonic mean). Volume of distribution was 3.01±1.69 L/kg. Following i.m. administration, maximum concentration (C(max)) was 1.74±0.09 ng/mL, which was significantly lower than the highest measured concentration (4.34±1.22 ng/mL) after i.v. administration (PBuprenorphine has a moderate T(1/2) in the horse and was detected at concentrations expected to be therapeutic in other species after i.v. and i.m. administration of 0.005 mg/kg. Signs of excitement and gastrointestinal stasis may be noted. © 2011 Blackwell Publishing Ltd.

  7. Paliperidone Palmitate Intramuscular 3-Monthly Formulation: A Review in Schizophrenia.

    Science.gov (United States)

    Lamb, Yvette N; Keating, Gillian M

    2016-10-01

    A 3-monthly formulation of intramuscular paliperidone palmitate (3-monthly paliperidone palmitate) has recently been approved for the maintenance treatment of schizophrenia in adult patients in the EU (Trevicta ® ), following earlier approval in the USA (Invega Trinza ® ). This narrative review discusses the clinical use of 3-monthly paliperidone palmitate in the maintenance treatment of schizophrenia in adult patients and summarizes its pharmacological properties. The efficacy of the 3-monthly paliperidone palmitate formulation as a maintenance treatment for schizophrenia has been demonstrated in well designed, phase III trials. Three-monthly paliperidone palmitate was more effective than placebo in delaying time to relapse and reducing relapse rates, and was noninferior to 1-monthly paliperidone palmitate in the proportion of patients that remained relapse-free. The 3-monthly formulation was also more effective than placebo in controlling the symptoms of schizophrenia, whilst not differing significantly from the 1-monthly formulation in terms of symptomatic control. Three-monthly paliperidone palmitate was generally well tolerated in clinical trials, with a tolerability profile consistent with that of the 1-monthly formulation. In conclusion, 3-monthly paliperidone palmitate is a useful treatment option for adult patients with schizophrenia who are adequately treated with the 1-monthly formulation, particularly for those who would prefer, or may benefit from, longer dosing intervals.

  8. INTRAMUSCULAR HYDATID CYST OF PARASPINAL MUSCLE: A RARE LOCATION

    Directory of Open Access Journals (Sweden)

    Bhargava Vardhana Reddy

    2015-05-01

    Full Text Available INTRODUCTION: Hydatid disease has a worldwide distribution and causes health problems in endemic countries. The parasite has a "dog - sheep" cycle with man as an intermediate accidental host. When humans ingest the eggs of the tapeworm, the embryos that emer ge penetrate the intestinal mucosa and are transported via the circulation to various organs. Most commonly they reach the liver, lungs and the other organs are rarely affected. Primary hydatid cyst of skeletal muscle is rare, occurring in 1 - 3% of all case s. (1,2 The prevalence of intramuscular hydatid disease is reported to be less than 0.5% , because muscle is an unfavourable site for infestation because of high levels of lactic acid in muscle. (3 The diagnosis is difficult because of the unusual location, low prevalence and complicated cysts may mimic solid or complex lesions. (4 The differential diagnosis in these cases must include malignant soft - tissue tumors such as myxoid liposarcoma, soft tissue abscesses and chronic hematoma. (5 Hydatid disease of h umans caused by Echinococcus granulosus has been recognized as a major public health problem. It is found in all sheep - raising countries of the world. In India, the highest prevalence is reported from Andhra Pradesh and Tamil Nadu. (6 Injudicious approach in the management of these rare presentations may be the root cause of severe anaphylactic shock and systemic dissemination. We report an unusual case of primary hydatidosis of the paraspinal muscles

  9. Iatrogenic axillary neuropathy after intramuscular injection of the deltoid muscle.

    Science.gov (United States)

    Davidson, Loren T; Carter, Gregory T; Kilmer, David D; Han, Jay J

    2007-06-01

    A previously healthy 26-yr-old male presented for an electrodiagnostic evaluation with complaints of significant right deltoid muscle atrophy and shoulder abduction weakness after receiving an intramuscular (IM) deltoid injection of an antiemetic 4 wk earlier. Electrodiagnostic evaluation confirmed an acute axillary neuropathy. We hypothesize that direct mechanical trauma to the anterior branch of the axillary nerve resulted in axillary mononeuropathy with axonal loss, although chemically induced nerve injury cannot be excluded. Injections in and about the shoulder complex are performed routinely for the purposes of vaccination, IM medication administration, deltoid trigger-point injections, and intra-articular and bursal steroid injections. Although such injections are considered routine office procedures, there is increased risk of neurovascular injury if they are performed incorrectly. The purpose of this brief report is to make practitioners aware of the potential for axillary neuropathy with such procedures, to review the salient anatomy, and to propose a potential guideline for clinical practice to minimize iatrogenic axillary neuropathy.

  10. Alternative method for intramuscular fat analysis using common laboratory equipment.

    Science.gov (United States)

    Segura, J; Calvo, L; Óvilo, C; González-Bulnes, A; Olivares, A; Cambero, M I; López-Bote, C J

    2015-05-01

    A procedure to quantify intramuscular fat was developed using common inexpensive laboratory equipment. Three homogenization methods of lyophilized muscle samples (Ball-mill, Grinder and Mortar) and two extraction methods (Ball-mill or Vortex) were used in turkey meat and pork. Two-hundred mg of lyophilized and homogenized samples were accurately weighed and mixed with 1.5 mL of dichloromethane-methanol (8:2) and shaken either in a Mixer Mill (MM400, Retsch Technology) or in a Vortex. The final mixture was separated by centrifugation. Solvent was evaporated under a nitrogen stream and lipid content was gravimetrically determined. Besides, it was checked that the fatty acid profile was not altered by the protocol used. Moreover, the analysis of 4 replicas from the same sample showed different variation coefficients (16-29%) for the new procedures proposed over a wide range of IMF content. The combination of Grinder and Vortex methodologies can be proposed as a simple and inexpensive alternative to previous ones. Copyright © 2015. Published by Elsevier Ltd.

  11. Intramuscular Olanzapine – a UK case series of early cases

    Directory of Open Access Journals (Sweden)

    Taylor Mark

    2007-04-01

    Full Text Available Abstract Background Clinical trials assessing efficacy and safety of Intramuscular (IM Olanzapine in acute schizophrenia and acute mania have previously been undertaken in studies required for drug registration in patients who were required to give informed consent. These patients may have less severe forms of psychosis than patients treated in routine practice. Data derived from naturalistic practice following the launch of IM olanzapine may be helpful for clinicians in assessing efficacy and safety of IM olanzapine. The PANSS-EC scale used in the clinical studies may represent a tool that could be used in routine clinical practice. Case presentation We report on an early unselected case series of 7 patients who received IM olanzapine in routine clinical practice settings in the UK. In this case series, olanzapine IM was generally effective, and no adverse events were reported. Adjunctive benzodiazepines were given concomitantly in 1 of the 7 subjects. This is relevant as concomitant benzodiazepines are not recommended for a minimum of 1 hour post IM olanzapine administration. PANSS-EC data was collected in 2 of the 7 subjects. Conclusion Although patients had greater severity of psychosis than clinical trial patients there were no unexpected findings. In addition the PANSS-EC scale is a scale that may be useful in assessing the efficacy of IM antipsychotics in routine clinical practice.

  12. BIOAVAILABILITY AND PHARMACOKINETICS OF NORFLOXACIN AFTER INTRAMUSCULAR ADMINISTRATION IN GOATS

    Directory of Open Access Journals (Sweden)

    WAJEEHA, F. H. KHAN AND I. JAVED

    2006-01-01

    Full Text Available Bioavailability and pharmacokinetics of two commercially available preparations of norfloxacin i.e. A (imported and B (locally prepared were determined in six healthy female goats after single intramuscular administration @ 5 mg/kg b.wt following crossover study design. The blood samples collected at 0.25, 0.5, 0.75, 1, 2, 3, 4, 6, 8 and 12 hours postmedication were also analysed for drug concentration by microbiological assay. Results revealed that preparation A showed higher (p<0.05 plasma drug levels than the preparation B at 1, 3, 6 and 8 hours after medication. Among bioavailability parameters AUC (g.h/ml and relative bioavailability (F% were higher for preparation A than the preparation B, while other parameters did not differ between the two preparations. Similarly, various pharmacokinetic parameters did not show any statistical difference between preparation A and B. The study revealed comparable elimination kinetics but different bioavailability of two commercial preparations of norfloxacin. It is concluded from the study that for optimal dosage regimen of drugs, the bioequivalence studies and kinetic behavior of the drugs are of paramount importance.

  13. Serial correlation between the ultrasonographic and pathologic findings of intramuscular hemorrhaging in an experimental rabbit

    Energy Technology Data Exchange (ETDEWEB)

    Ko, Kyung Ran [National Cancer Center, Seoul (Korea, Republic of); Ryu, Kyung Nam; Park, Ji Seon; Jin, Wook; Sung, Dong Wook; Park, Yong Koo [KyungHee University Medical Center, Seoul (Korea, Republic of)

    2008-05-15

    To evaluate the serial ultrasonographic findings of experimental intramuscular hemorrhaging to determine if there is a correlation with the pathologic findings. An ultrasonography (US) was performed before and immediately after an intramuscular blood injection in nine rabbits. In addition, follow-up US images were obtained at 1, 4, 7, 10, 14, 21, and 28 days after the intramuscular blood injections in seven of the rabbits. The pathologic specimens, compared to the US findings on each date, and consisted of samples of left thigh muscle. A US, performed immediately after a blood injection, showed two patterns; 6 cases of hyperechoic muscle thickening and 3 cases of hyperechoic muscle thickening with extravasation between the epimysium and muscle bundle or within muscle bundle. A follow-up US showed a marked decrease in intramuscular hemorrhaging and microcalcifications, which appeared on the 4th, 7th and 10th day after the blood injection. The pathologic findings revealed several short echogenic lines in the muscular bundles which were hemosiderin. Moreover, a 28 day follow-up US revealed that the normal findings are correlated with the normal gross pathologic findings. The US findings of the intramuscular hemorrhaging, for each of the follow-up dates, in comparison to the pathologic findings, revealed a high correlation with the pathologic specimens. Consequently, a US transducer with high resolution can be considered as a helpful technique in the diagnosing and evaluating the follow-up treatment of intramuscular hemorrhaging.

  14. Serial correlation between the ultrasonographic and pathologic findings of intramuscular hemorrhaging in an experimental rabbit

    International Nuclear Information System (INIS)

    Ko, Kyung Ran; Ryu, Kyung Nam; Park, Ji Seon; Jin, Wook; Sung, Dong Wook; Park, Yong Koo

    2008-01-01

    To evaluate the serial ultrasonographic findings of experimental intramuscular hemorrhaging to determine if there is a correlation with the pathologic findings. An ultrasonography (US) was performed before and immediately after an intramuscular blood injection in nine rabbits. In addition, follow-up US images were obtained at 1, 4, 7, 10, 14, 21, and 28 days after the intramuscular blood injections in seven of the rabbits. The pathologic specimens, compared to the US findings on each date, and consisted of samples of left thigh muscle. A US, performed immediately after a blood injection, showed two patterns; 6 cases of hyperechoic muscle thickening and 3 cases of hyperechoic muscle thickening with extravasation between the epimysium and muscle bundle or within muscle bundle. A follow-up US showed a marked decrease in intramuscular hemorrhaging and microcalcifications, which appeared on the 4th, 7th and 10th day after the blood injection. The pathologic findings revealed several short echogenic lines in the muscular bundles which were hemosiderin. Moreover, a 28 day follow-up US revealed that the normal findings are correlated with the normal gross pathologic findings. The US findings of the intramuscular hemorrhaging, for each of the follow-up dates, in comparison to the pathologic findings, revealed a high correlation with the pathologic specimens. Consequently, a US transducer with high resolution can be considered as a helpful technique in the diagnosing and evaluating the follow-up treatment of intramuscular hemorrhaging

  15. Desenvolvimento de um curso on-line sobre o tema administração de medicamentos

    OpenAIRE

    Cassiani, Silvia Helena De Bortoli; Benfati, Flávia Borges da Silva; Dias, Denise Costa; Zem-Mascarenhas, Silvia Helena; Zanetti, Maria Lúcia

    2003-01-01

    O estudo descreveu o desenvolvimento de um curso on-line sobre o processo da administração de medicamentos - vias. Para tanto se utilizou o World Wide Web Course Tools (WebCT), que é um software que fornece várias ferramentas a supervisores e acesso a estudantes providos de uma senha a diversos ambientes. O material do curso foi subdivido em oito tópicos ilustrados: administração de medicamentos por via oral, sublingual, via parenteral, intradérmica, subcutânea, intramuscular, endovenosa e ap...

  16. Development and evaluation of a recombinant DNA vaccine candidate expressing porcine circovirus 2 structural protein Desenvolvimento e avaliação de um candidato à vacina de DNA recombinante expressando a proteína estrutural do circovírus suíno

    Directory of Open Access Journals (Sweden)

    Abelardo Silva Júnior

    2009-01-01

    Full Text Available Porcine circovirus 2 (PCV2 is generally associated with the porcine circovirosis syndrome, which is considered an important disease of swine and has potentially serious economic impact on the swine industry worldwide. This article describes the construction of a recombinant plasmid expressing the PCV2 structural protein and the evaluation of cellular and humoral immune responses produced by this recombinant vaccine in BALB/c mice. The vaccine candidate was obtained and analyzed in vivo, in an effort to determine the ability to induce a specific immune response in mice. DNA was extracted from a Brazilian PCV2 isolate and the gene coding for Cap protein was amplified by PCR and inserted into an expression plasmid. Groups of BALB/c mice were inoculated intra-muscularly and intradermally in a 15-day interval, with 100 µg and 50 µg of the vaccine construct, respectively. Another group was inoculated intramuscularly with 100 µg of empty plasmid, corresponding to the control group. Seroconversion and cellular response in BALB/c mice were compared and used for vaccine evaluation. Seroconversion was analyzed by ELISA. After a series of 3 immunizations the spleen cells of the immunized animals were used to perform lymphocyte proliferation assays. Seroconversion to PCV2 was detected by ELISA in the animals inoculated with the vaccine construct when compared with control groups. Lymphocyte proliferation assays showed a stronger cell proliferation in the inoculated animals compared with the control group. Thus, the vaccine candidate construct demonstrated to be able to induce both humoral and cellular responses in inoculated mice.O circovírus suíno 2 (PCV2 é geralmente associado à síndrome da circovirose suína, que é considerada uma importante doença de suínos e possui um sério impacto econômico na suinocultura mundial. Este trabalho descreve a construção de um plasmídeo recombinante que expressa a proteína estrutural do PCV2 e a avalia

  17. Um estudo empírico de um sistema de reconhecimento facial utilizando o classificador KNN

    Directory of Open Access Journals (Sweden)

    Fabio Abrantes Diniz

    2016-06-01

    Full Text Available Neste artigo, apresenta-se um estudo empírico de otimização das taxas de acurácias resultantes de um sistema de reconhecimento facial baseado nas técnicas Eigenfaces e K-Nearest Neighbors. Foram investigadas as seguintes variáveis: imagens com três dimensões distintas, número de características (Eigenfaces, valores de k da técnica K-Nearest Neighbors e três medidas de distância (euclidiana, Manhattan e euclidiana normalizada. Os estudos foram importantes para entender empiricamente quais parâmetros são os mais relevantes para as técnicas analisadas e que resultam em melhores taxas de acurácias de reconhecimento facial. Os resultados dos experimentos comprovaram que as imagens com dimensões 12x9 pixels produzem as melhores taxas de acurácias de reconhecimento facial, combinando com a medida de distância euclidiana normalizada e um número de Eigenfaces igual a vinte.

  18. OS CAMINHOS DO DIREITO: OBSTÁCULOS, FERRAMENTAS E PROCEDIMENTOS IMPORTANTES PARA SE GARANTIR A EFETIVIDADE DA LEI

    Directory of Open Access Journals (Sweden)

    DÉBORA SUELEN GOMES DE SOUZA

    2012-06-01

    Full Text Available Este artigo de revisão discute o papel do Tribunal de Justiça na Bahia a fim de promover um direito constitucionalmente previsto e teoricamente garantido, o acesso à justiça. A princípio, a abordagem se faz por meio da teoria sociológica sobre o campo jurídico. Tomamos o texto literário Diante da Lei, de Franz Kafka, como fundamento para discutir a teoria de Pierre Bordieu sobre o poder simbólico e os tipos de capitais presentes no campo jurídico. A revisão bibliográfica sobre o acesso a justiça reflete sobre as exigências e as restrições que a população, especificamente a mais pobre, enfrenta para buscar a efetividade do direito. Apesar de o acesso ser, teoricamente, direito de todos, de forma a obedecer à isonomia Constitucional, o que acontece é uma seletividade decorrente daquilo que se exige de forma direta ou indireta para adentrar ao campo jurídico. Ou seja, os critérios formais e os laços estreitos da justiça com as classes mais favorecidas implica numa refinagem a respeito de quem tem poder ou não para acessar este campo. Destacam-se as peculiaridades das normas constitucionais que deveriam ser direcionadas à sociedade como um todo, através de análise das funções dos magistrados que possuem a responsabilidade para exercer, efetivar e promover essas normas, além de analisarmos criticamente a respeito das instituições que auxiliam na efetivação desses direitos. Aborda-se assim, as condições que não condizem com os parâmetros constitucionais estabelecidos pelo Estado Democrático de Direito e pelo principio da isonomia que estabelece igualdade de direito para todos os indivíduos.Palavras-chave: poder simbólico; acesso a justiça; campo jurídico; democracia ABSTRACTThis review article discusses the role of the Court in Bahia to promote a right constitutionally theoretically predicted and guaranteed access to justice. In principle, the approach is done through the sociological theory about the legal

  19. Geodiversidade, Geoconservação e Geoturismo – trinômio importante para a proteção do patrimônio geológico

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    Lilian Carla Moreira Bento

    2009-08-01

    Full Text Available RESENHALEITE DO NASCIMENTO, M. A. L. do; RUCHKYS, U. A.; MANTESSO-NETO, V. Geodiversidade, Geoconservação eGeoturismo – trinômio importante para a proteção do patrimônio geológico. São Paulo: Sociedade Brasileira de Geologia,2008. 82 p.Geodiversidade, Geoconservação e Geoturismo– trinômio importante para a proteção dopatrimônio geológico é o primeiro livro brasileiro quetrata dessa temática que surgiu nos países europeus nadécada de 1990 e hoje alcança um público cada vezmais crescente.Lançado pela Sociedade Brasileira de Geologiaem 2008, traduz-se numa obra de relevante importânciapara aqueles que pretendem trabalhar na áreado trinômio, trazendo conceitos-chave, tais comogeodiversidade, geoconservação e geoturismo e reflexõesindispensáveis para uma análise crítica do tema.Escrito por três grandes especialistas na áreade Geologia e atuantes na área de geoturismo, patrimôniogeológico e geoconservação, está estruturadoem três capítulos: Geodiversidade, Geoconservaçãoe Geoturismo, e traz como anexos documentos importantesrelacionados à temática (Declaração Internacionaldos Direitos à Memória da Terra e Declaraçãode Aracaju, bem como uma rica lista de bibliografiasbrasileiras sobre o trinômio, permitindo ao leitorum aprofundamento no tema.

  20. Effect of intramuscular cholecalciferol megadose in children with nutritional rickets.

    Science.gov (United States)

    Bothra, Meenakshi; Gupta, Nandita; Jain, Vandana

    2016-06-01

    The treatment practices for vitamin D deficiency rickets are highly variable. Though a single intramuscular (IM) megadose of vitamin D is economical, and ensures good compliance, it poses the risk of hypervitaminosis D. This observational study was conducted to assess the duration of effect and safety of single IM megadose of cholecalciferol in the treatment of vitamin D deficiency rickets. Children younger than 14 years with rickets were enrolled. Baseline investigations included radiograph of wrists and estimation of serum calcium, phosphate, alkaline phosphatase (ALP), 25(OH) vitamin D and parathormone (PTH) levels. All children received a single IM megadose of vitamin D3. Biochemical parameters were re-evaluated at 1.5, 3 and 6 months after the megadose and the values were compared to the baseline. We enrolled 21 children, out of which nine remained under active follow-up till 6 months. Radiological evidence of rickets was present in all 21 children, 14 had hypocalcemia at the time of presentation. After IM cholecalciferol megadose, median 25 hydroxy vitamin D [25(OH)D] level remained significantly more than the baseline till 6 months after the megadose. At 1.5 months after the vitamin D megadose, three (30%) of the children were found to develop toxic levels of vitamin D (>150 ng/mL), although none had hypercalcemia or any clinical manifestation of vitamin D toxicity. At 3 months and 6 months after the megadose, 25(OH)D levels remained in the sufficient range (20-100 ng/mL) in seven out of the eight children who came for follow-up. A single IM megadose of vitamin D may be effective in significantly increasing the 25(OH)D levels for at least 6 months in children with rickets, but elevation of 25(OH)D to toxic range raises concern regarding its safety.

  1. Intramuscular architecture of the autochthonous back muscles in humans

    Science.gov (United States)

    Stark, Heiko; Fröber, Rosemarie; Schilling, Nadja

    2013-01-01

    Many training concepts take muscle properties such as contraction speed or muscle topography into account to achieve an optimal training outcome. Thus far, the internal architecture of muscles has largely been neglected, although it is well known that parameters such as pennation angles or the lengths of fascicles but also the proportions of fleshy and tendinous fascicle parts have a major impact on the contraction behaviour of a muscle. Here, we present the most detailed description of the intramuscular fascicle architecture of the human perivertebral muscles available so far. For this, one adult male cadaver was studied. Our general approach was to digitize the geometry of each fascicle of the muscles of back proper (Erector spinae) – the Spinalis thoracis, Iliocostalis lumborum, Longissimus thoracis and the Multifidus thoracis et lumborum – and of the deep muscles of the abdomen – Psoas minor, Psoas major and Quadratus lumborum – during a layerwise dissection. Architectural parameters such as fascicle angles to the sagittal and the frontal planes as well as fascicle lengths were determined for each fascicle, and are discussed regarding their consequences for the function of the muscle. For example, compared with the other dorsovertebral muscles, the Longissimus thoracis can produce greater shortening distances because of its relatively long fleshy portions, and it can store more elastic energy due to both its relatively long fleshy and tendinous fascicle portions. The Quadratus lumborum was outstanding because of its many architectural subunits defined by distinct attachment sites and fascicle lengths. The presented database will improve biomechanical models of the human trunk by allowing the incorporation of anisotropic muscle properties such as the fascicle direction into finite element models. This information will help to increase our understanding of the functionality of the human back musculature, and may thereby improve future training concepts

  2. Intramuscular fiber conduction velocity, isometric force and explosive performance

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    Methenitis Spyridon

    2016-06-01

    Full Text Available Conduction of electrical signals along the surface of muscle fibers is acknowledged as an essential neuromuscular component which is linked with muscle force production. However, it remains unclear whether muscle fiber conduction velocity (MFCV is also linked with explosive performance. The aim of the present study was to investigate the relationship between vastus lateralis MFCV and countermovement jumping performance, the rate of force development and maximum isometric force. Fifteen moderately-trained young females performed countermovement jumps as well as an isometric leg press test in order to determine the rate of force development and maximum isometric force. Vastus lateralis MFCV was measured with intramuscular microelectrodes at rest on a different occasion. Maximum MFCV was significantly correlated with maximum isometric force (r = 0.66, p < 0.01, nevertheless even closer with the leg press rate of force development at 100 ms, 150 ms, 200 ms, and 250 ms (r = 0.85, r = 0.89, r = 0.91, r = 0.92, respectively, p < 0.01. Similarly, mean MFCV and type II MFCV were better correlated with the rate of force development than with maximum isometric leg press force. Lower, but significant correlations were found between mean MFCV and countermovement jump power (r = 0.65, p < 0.01. These data suggest that muscle fiber conduction velocity is better linked with the rate of force development than with isometric force, perhaps because conduction velocity is higher in the larger and fastest muscle fibers which are recognized to contribute to explosive actions.

  3. Cost-effectiveness of an influenza vaccination program offering intramuscular and intradermal vaccines versus intramuscular vaccine alone for elderly.

    Science.gov (United States)

    Leung, Man-Kit; You, Joyce H S

    2016-05-11

    Intradermal (ID) injection is an alternative route for influenza vaccine administration in elderly with potential improvement of vaccine coverage. This study aimed to investigate the cost-effectiveness of an influenza vaccination program offering ID vaccine to elderly who had declined intramuscular (IM) vaccine from the perspective of Hong Kong public healthcare provider. A decision analytic model was used to simulate outcomes of two programs: IM vaccine alone (IM program), and IM or ID vaccine (IM/ID program) in a hypothetic cohort of elderly aged 65 years. Outcome measures included influenza-related direct medical cost, infection rate, mortality rate, quality-adjusted life years (QALYs) loss, and incremental cost per QALY saved (ICER). Model inputs were derived from literature. Sensitivity analyses evaluated the impact of uncertainty of model variables. In base-case analysis, the IM/ID program was more costly (USD52.82 versus USD47.59 per individual to whom vaccine was offered) with lower influenza infection rate (8.71% versus 9.65%), mortality rate (0.021% versus 0.024%) and QALYs loss (0.00336 versus 0.00372) than the IM program. ICER of IM/ID program was USD14,528 per QALY saved. One-way sensitivity analysis found ICER of IM/ID program to exceed willingness-to-pay threshold (USD39,933) when probability of influenza infection in unvaccinated elderly decreased from 10.6% to 5.4%. In 10,000 Monte Carlo simulations of elderly populations of Hong Kong, the IM/ID program was the preferred option in 94.7% of time. An influenza vaccination program offering ID vaccine to elderly who had declined IM vaccine appears to be a highly cost-effective option. Copyright © 2016 Elsevier Ltd. All rights reserved.

  4. The adipokine Chemerin induces lipolysis and adipogenesis in bovine intramuscular adipocytes.

    Science.gov (United States)

    Fu, Yuan-Yuan; Chen, Kun-Lin; Li, Hui-Xia; Zhou, Guang-Hong

    2016-07-01

    The adipokine Chemerin is reported to regulate adipogenesis and glucose homeostasis in vivo and in 3T3-L1 cells. Our team is focused on the role of Chemerin in metabolism and intramuscular adipocyte differentiation because intramuscular fat is the basic material for the formation of marbling in livestock and poultry meat. In this study, bovine intramuscular mature adipocytes were cultured in medium with Chemerin, and the process of lipolysis of mature adipocytes and the adipogenesis of de-differentiated preadipocytes were investigated. The results showed that Chemerin induced significant lipolytic metabolism in intramuscular mature adipocytes, indicated by increased levels of glycerol, FFA, and up-regulated expression of the lipolysis critical factors HSL, LPL, and leptin. Meanwhile, the expressions of adipogenic key factors PPARγ, C/EBPα, and A-FABP were decreased by Chemerin during lipolysis or dedifferentiation in mature adipocytes. The de-differentiated preadipocytes could re-differentiate into mature adipocytes. Intriguingly, the formation of cells' lipid droplets was promoted by Chemerin during preadipocyte differentiation. In addition, mRNA and protein expressions of PPARγ, C/EBPα, and A-FABP were up-regulated by Chemerin during preadipocytes differentiation. These results suggest that Chemerin promotes lipolysis in mature adipocytes and induces adipogenesis during preadipocyte re-differentiation, further indicating a dual role for Chemerin in the deposition of intramuscular fat in ruminant animals.

  5. FDG PET/CT and MR imaging of intramuscular myxoma in the gluteus maximus.

    Science.gov (United States)

    Nishio, Jun; Naito, Masatoshi

    2012-06-30

    Intramuscular myxoma is a rare benign soft tissue tumor which may be mistaken for other benign and low-grade malignant myxoid neoplasms. We present the case of a 63-year-old woman with an asymptomatic intramuscular myxoma discovered incidentally on a whole-body F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography. PET images showed a mild FDG uptake (maximum standardized uptake value, 1.78) in the left gluteus maximus. Subsequent magnetic resonance (MR) imaging revealed a well-defined ovoid mass with homogenous low signal intensity on T1-weighted sequences and markedly high signal intensity on T2-weighted sequences. Contrast-enhanced MR images showed heterogeneous enhancement throughout the mass. The diagnosis of intramuscular myxoma was confirmed on histopathology after surgical excision of the tumor. The patient had no local recurrence at one year follow-up. Our case suggests that intramuscular myxoma should be considered in the differential diagnosis of an oval-shaped intramuscular soft tissue mass with a mild FDG uptake.

  6. FDG PET/CT and MR imaging of intramuscular myxoma in the gluteus maximus

    Directory of Open Access Journals (Sweden)

    Nishio Jun

    2012-06-01

    Full Text Available Abstract Intramuscular myxoma is a rare benign soft tissue tumor which may be mistaken for other benign and low-grade malignant myxoid neoplasms. We present the case of a 63-year-old woman with an asymptomatic intramuscular myxoma discovered incidentally on a whole-body F-18 fluorodeoxyglucose (FDG positron emission tomography (PET/computed tomography. PET images showed a mild FDG uptake (maximum standardized uptake value, 1.78 in the left gluteus maximus. Subsequent magnetic resonance (MR imaging revealed a well-defined ovoid mass with homogenous low signal intensity on T1-weighted sequences and markedly high signal intensity on T2-weighted sequences. Contrast-enhanced MR images showed heterogeneous enhancement throughout the mass. The diagnosis of intramuscular myxoma was confirmed on histopathology after surgical excision of the tumor. The patient had no local recurrence at one year follow-up. Our case suggests that intramuscular myxoma should be considered in the differential diagnosis of an oval-shaped intramuscular soft tissue mass with a mild FDG uptake.

  7. Intramuscular Heating Characteristics of Multihour Low-Intensity Therapeutic Ultrasound.

    Science.gov (United States)

    Rigby, Justin H; Taggart, Rebecca M; Stratton, Kelly L; Lewis, George K; Draper, David O

    2015-11-01

    The heating characteristics of a stationary device delivering sustained acoustic medicine with low-intensity therapeutic ultrasound (LITUS) are unknown. To measure intramuscular (IM) heating produced by a LITUS device developed for long-duration treatment of musculoskeletal injuries. Controlled laboratory study. University research laboratory. A total of 26 healthy volunteers (16 men, 10 women; age = 23.0 ± 2.1 years, height = 1.74 ± 0.09 m, mass = 73.48 ± 14.65 kg). Participants were assigned randomly to receive active (n = 20) or placebo (n = 6) LITUS at a frequency of 3 MHz and an energy intensity of 0.132 W/cm(2) continuously for 3 hours with a single transducer or dual transducers on the triceps surae muscle. We measured IM temperature using thermocouples inserted at 1.5- and 3-cm depths into muscle. Temperatures were recorded throughout treatment and 30 minutes posttreatment. We used 2-sample t tests to determine the heating curve of the LITUS treatment and differences in final temperatures between depth and number of transducers. A mild IM temperature increase of 1 °C was reached 10 ± 5 minutes into the treatment, and a more vigorous temperature increase of 4 °C was reached 80 ± 10 minutes into the treatment. The maximal steady-state IM temperatures produced during the final 60 minutes of treatment at the 1.5-cm depth were 4.42 °C ± 0.08 °C and 3.92 °C ± 0.06 °C using 1 and 2 transducers, respectively. At the 3.0-cm depth, the maximal steady-state IM temperatures during the final 60 minutes of treatment were 3.05 °C ± 0.09 °C and 3.17 °C ± 0.05 °C using 1 and 2 transducers, respectively. We observed a difference between the temperatures measured at each depth (t78 = -2.45, P = .02), but the number of transducers used to generate heating was not different (t78 = 1.79, P = .08). The LITUS device elicited tissue heating equivalent to traditional ultrasound but could be sustained for multiple hours. It is a safe and effective alternative tool

  8. Intramuscular aripiprazole in the acute management of psychomotor agitation.

    Science.gov (United States)

    De Filippis, Sergio; Cuomo, Ilaria; Lionetto, Luana; Janiri, Delfina; Simmaco, Maurizio; Caloro, Matteo; De Persis, Simone; Piazzi, Gioia; Simonetti, Alessio; Telesforo, C Ludovica; Sciarretta, Antonio; Caccia, Federica; Gentile, Giovanna; Kotzalidis, Georgios D; Girardi, Paolo

    2013-06-01

    To assess acute efficacy and safety of 9.75 mg of intramuscular (IM) injections of the atypical antipsychiatric aripiprazole in patients with schizophrenia or bipolar disorder and acute agitation. Open-label trial of IM injections of aripiprazole and 24-hour monitoring of clinical response in patients with major psychoses and acute agitation. Partial analysis of blood levels of the administered drug to correlate with clinical response. Acute psychiatric care wards in a single university hospital. A total of 201 acutely agitated patients (79 with schizophrenia and 122 with bipolar disorder I). Aripiprazole 9.75 mg IM injection. We evaluated clinical response using the Excitatory Component of the Positive and Negative Syndrome Scale (PANSS-EC), the Agitation/Calmness Evaluation Scale (ACES), and the Clinical Global Impressions scale (CGI). Assessments were conducted 30, 60, 90, and 120 minutes and 24 hours after the first injection for PANSS-EC and ACES, and 2, 4, 6, and 24 hours for CGI. Response was at least a 40% decrease in PANSS-EC scores. We measured serum aripiprazole and dehydroaripiprazole levels in a subsample. IM aripiprazole significantly improved clinical measures. PANSS-EC improved progressively, starting after 30 minutes. ACES improved after 90 minutes and continued thereafter. Effects were sustained, with steadily decreasing CGI scores, until the 24th hour. Response rate was 83.6% after 2 hours, but with repeat injections, it rose to over 90% with no differences among diagnostic groups. Although there were gender differences in the response to individual PANSS-EC items, the responses were similar overall. Neither clinical monitoring nor patient reporting revealed any side effects. No therapeutic window was identified, and levels did not correlate with any clinical measure. Aripiprazole was effective and safe in reducing acute agitation in patients with bipolar disorder or schizophrenia. Our results compare favorably to double-blind trials, probably

  9. The IDvIP trial: a two-centre randomised double-blind controlled trial comparing intramuscular diamorphine and intramuscular pethidine for labour analgesia.

    Science.gov (United States)

    Wee, Michael Y K; Tuckey, Jenny P; Thomas, Peter; Burnard, Sara

    2011-07-08

    Intramuscular pethidine is routinely used throughout the UK for labour analgesia. Studies have suggested that pethidine provides little pain relief in labour and has a number of side effects affecting mother and neonate. It can cause nausea, vomiting and dysphoria in mothers and can cause reduced fetal heart rate variability and accelerations. Neonatal effects include respiratory depression and impaired feeding. There are few large studies comparing the relative side effects and efficacy of different opioids in labour. A small trial comparing intramuscular pethidine with diamorphine, showed diamorphine to have some benefits over pethidine when used for labour analgesia but the study did not investigate the adverse effects of either opioid. The Intramuscular Diamorphine versus Intramuscular Pethidine (IDvIP) trial is a randomised double-blind two centre controlled trial comparing intramuscular diamorphine and pethidine regarding their analgesic efficacy in labour and their side effects in mother, fetus and neonate. Information about the trial will be provided to women in the antenatal period or in early labour. Consent and recruitment to the trial will be obtained when the mother requests opioid analgesia. The sample size requirement is 406 women with data on primary outcomes. The maternal primary outcomes are pain relief during the first 3 hours after trial analgesia and specifically pain relief after 60 minutes. The neonatal primary outcomes are need for resuscitation and Apgar Score analgesia, whether method of analgesia would be used again, use of Entonox, umbilical arterial and venous pH, fetal heart rate, meconium staining, time from delivery to first breath, Apgar scores at 5 mins, naloxone requirement, transfer to neonatal intensive care unit, neonatal haemoglobin oxygen saturation at 30, 60, 90, and 120 mins after delivery, and neonatal sedation and feeding behaviour during first 2 hours. If the trial demonstrates that diamorphine provides better analgesia

  10. Xantelasma: relato de um caso Eyelid xanthelasma: a case report

    Directory of Open Access Journals (Sweden)

    André Henrique Miranda

    2001-04-01

    Full Text Available Os autores relatam um caso raro em paciente do sexo masculino, de 71 anos de idade, com história de surgimento de "carocinho" na pálpebra superior direita há nove anos, que teve aumento importanteum ano. A tomografia computadorizada evidenciou espessamento da musculatura do reto lateral e de partes moles adjacentes. O diagnóstico pela biópsia foi de xantelasma.The authors report a rare case of a 71-year-old male patient with a 9-year history of appearance of a "little node" in the right superior eyelid, which increased significantly in size in the last year. Computed tomography showed thickening of the lateral rectus muscle and adjacent soft tissues. The diagnosis after biopsy was xanthelasma.

  11. Efficacy and Tolerability of Intramuscular Dexketoprofen in Postoperative Pain Management following Hernia Repair Surgery.

    Science.gov (United States)

    Jamdade, P T; Porwal, A; Shinde, J V; Erram, S S; Kamat, V V; Karmarkar, P S; Bhagtani, K; Dhorepatil, S; Irpatgire, R; Bhagat, H; Kolte, S S; Shirure, P A

    2011-01-01

    Objective. To evaluate the safety and efficacy of intramuscular dexketoprofen for postoperative pain in patients undergoing hernia surgery. Methodology. Total 202 patients received single intramuscular injection of dexketoprofen 50 mg or diclofenac 50 mg postoperatively. The pain intensity (PI) was self-evaluated by patients on VAS at baseline 1, 2, 4, 6, and 8 hours. The efficacy parameters were number of responders, difference in PI (PID) at 8 hours, sum of analogue of pain intensity differences (SAPID), and onset and duration of analgesia. Tolerability assessment was done by global evaluation and adverse events in each group. Results. Dexketoprofen showed superior efficacy in terms of number of responders (P = .007), PID at 8 hours (P = .02), and SAPID( 0-8 hours ) (P dexketoprofen trometamol 50 mg given intramuscularly provided faster, better, and longer duration of analgesia in postoperative patients of hernia repair surgery than diclofenac 50 mg, with comparable safety.

  12. Distribution of enrofloxacin in intestinal tissue and contents of healthy pigs after oral and intramuscular administrations

    DEFF Research Database (Denmark)

    Wiuff, C.; Lykkesfeldt, J.; Aarestrup, Frank Møller

    2002-01-01

    The concentration of enrofloxacin in plasma, intestinal tissue, lymph nodes and intestinal contents was investigated in healthy pigs after oral (p.o.) and intramuscular (i.m.) administration of a single dose of 2.5 mg/kg bw. Tissue and content samples were collected from jejunum, ileum, caecum...... and colon from pigs killed at 2, 3 and 6 h after dosing. Intramuscular administration resulted in significantly higher concentrations in plasma, intestinal tissue and lymph nodes at 2 h but not at 3 or 6 h compared with p.o. administration. The absorption and distribution phase was longer after oral....... On the basis of these results it was concluded that in order to ensure an immediate high concentration of enrofloxacin, and thereby avoid an initial selection for resistant mutants, the intramuscular route seems to be preferable to the oral route....

  13. Intramuscular myxoma of the face: an unusual localization. A clinicopathological study.

    Science.gov (United States)

    Orlandi, A; Bianchi, L; Marino, B; Spagnoli, L G; Nini, G

    1995-03-01

    Intramuscular myxoma is a rare benign mesenchymal lesion. Only very rare cases of cutaneous localization of this tumor have been described, in particular related to the somatic soft tissues of the face. This unusual localization may clinically mimic nodular or cystic facial lesions having different origins. The aim of our work was to well characterize the phenotype of the spindle cells characteristic of intramuscular mixoma. Tissue samples were processed for morphological and ultrastructural studies. Moreover, immunohistochemical stainings were performed to characterize the expression of different nonmuscular and muscular cytoskeletal proteins. The tumor was composed of sparse spindle cells embedded in a prominent mucoid matrix. Besides the predominance of a fibroblast-like appearance, some neoplastic cells displayed immunohistochemical and ultrastructural features resembling either myofibroblasts or primitive mesenchymal cells, with a modulation of cell actin expression. The presence of multiple phenotypes of nonmuscular, mesenchymal pathway of differentiation can be considered a peculiar feature of intramuscular myxoma.

  14. Nitrocobinamide, a new cyanide antidote that can be administered by intramuscular injection.

    Science.gov (United States)

    Chan, Adriano; Jiang, Jingjing; Fridman, Alla; Guo, Ling T; Shelton, G Diane; Liu, Ming-Tao; Green, Carol; Haushalter, Kristofer J; Patel, Hemal H; Lee, Jangwoen; Yoon, David; Burney, Tanya; Mukai, David; Mahon, Sari B; Brenner, Matthew; Pilz, Renate B; Boss, Gerry R

    2015-02-26

    Currently available cyanide antidotes must be given by intravenous injection over 5-10 min, making them ill-suited for treating many people in the field, as could occur in a major fire, an industrial accident, or a terrorist attack. These scenarios call for a drug that can be given quickly, e.g., by intramuscular injection. We have shown that aquohydroxocobinamide is a potent cyanide antidote in animal models of cyanide poisoning, but it is unstable in solution and poorly absorbed after intramuscular injection. Here we show that adding sodium nitrite to cobinamide yields a stable derivative (referred to as nitrocobinamide) that rescues cyanide-poisoned mice and rabbits when given by intramuscular injection. We also show that the efficacy of nitrocobinamide is markedly enhanced by coadministering sodium thiosulfate (reducing the total injected volume), and we calculate that ∼1.4 mL each of nitrocobinamide and sodium thiosulfate should rescue a human from a lethal cyanide exposure.

  15. Intrarectal quinine versus intravenous or intramuscular quinine for treating Plasmodium falciparum malaria.

    Science.gov (United States)

    Eisenhut, Michael; Omari, Aika A A

    2009-01-21

    In children with falciparum malaria, a proprietary quinine preparation (adjusted to make it less acidic) administered rectally may be easier to use and less painful than intramuscular or intravenous administration. However, rectal quinine may be less effective. To compare intrarectal quinine with intravenous or intramuscular quinine for treating malaria caused by Plasmodium falciparum. In May 2008, we searched the Cochrane Infectious Diseases Group Specialized Register, CENTRAL (The Cochrane Library 2008, Issue 2), MEDLINE, EMBASE, LILACS, and CINAHL. We also searched conference proceedings, contacted individual researchers and a pharmaceutical company, and checked reference lists. Randomized and quasi-randomized controlled trials comparing intrarectal quinine with intramuscular and intravenous quinine for treating people with uncomplicated and severe Plasmodium falciparum malaria. We independently assessed each trial's risk of bias quality and extracted data, including adverse event data. We analysed dichotomous data using the odds ratio and continuous data using the mean difference. Ten randomized controlled trials, all involving children only (total of 1417 children), fulfilled the inclusion criteria. The same investigator was involved in nine of the trials. Seven trials compared proprietary intrarectal with intravenous quinine, and seven trials compared it with intramuscular treatment. We detected no statistically significant difference between intrarectal and intravenous or intramuscular routes for death, parasite clearance by 48 hours and seven days, parasite clearance time, fever clearance time, coma recovery time, duration of hospitalization, and time to drinking. The trials reporting on these outcomes were small, which resulted in large confidence intervals for all outcomes apart from duration of hospitalization. One large trial (898 children) reported that intrarectal was less painful than intramuscular administration. We detected no difference in the

  16. Effect of Doll Injection Display on Pain Intensity due to Intramuscular Injection in Preschool Children

    Directory of Open Access Journals (Sweden)

    H. Irani

    2016-09-01

    Full Text Available Aims: Pains caused by the invasive actions such as intramuscular injection lead to the physical and mental tensions in the children. Therefore, such pains should be given relief. One of the main priorities in the nursing is to notice methods that reduce pains due to the invasive actions in the children. The aim of this study was to investigate the effects of injection displayed on a doll on the pain intensity due to the intramuscular injection in the preschool children. Materials & Methods: In the randomized controlled clinical trial, 62 kids aged between 4 and 6 years with pharyngitis were studied in the clinic of the health network of Khalil-abad Township in 2015. The intramuscular injection of penicillin 6.3.3 was administrated for the kids. The subjects, selected by simple lottery, were divided into two groups including experimental and control groups (n=31 per group. Data was collected using a demographic characteristic collecting form and Oucher standard pain assessment tool. In experimental group, the kid watching, one intramuscular injection was displayed on a doll by a nurse; then, the kid underwent an intramuscular injection. In control group, the routine injection method was done. Data was analyzed by SPSS 19 software using Mann-Whitney, independent T, and Chi-square tests. Findings: Mean pain intensity after injection in experimental group (3.22±0.90 was significantly lower than control group (4.19±0.83; p<0.001. Conclusion: The injection displayed on a doll before the intramuscular injection might lead to pain reduction in the preschool kids.

  17. Systemic and local immune response in pigs intradermally and intramuscularly injected with inactivated Mycoplasma hyopneumoniae vaccines.

    Science.gov (United States)

    Martelli, P; Saleri, R; Cavalli, V; De Angelis, E; Ferrari, L; Benetti, M; Ferrarini, G; Merialdi, G; Borghetti, P

    2014-01-31

    The systemic and respiratory local immune response induced by the intradermal administration of a commercial inactivated Mycoplasma hyopneumoniae whole-cell vaccine (Porcilis(®) MHYO ID ONCE - MSD AH) in comparison with two commercial vaccines administered via the intramuscular route and a negative control (adjuvant only) was investigated. Forty conventional M. hyopneumoniae-free pigs were randomly assigned to four groups (ten animals each): Group A=intradermal administration of the test vaccine by using the needle-less IDAL(®) vaccinator at a dose of 0.2 ml; Group B=intramuscular administration of a commercially available vaccine (vaccine B); Group C=intramuscular administration of the adjuvant only (2 ml of X-solve adjuvant); Group D=intramuscular administration of a commercially available vaccine (vaccine D). Pigs were vaccinated at 28 days of age. Blood and bronchoalveolar lavage (BAL) fluid samples were collected at vaccination (blood only), 4 and 8 weeks post-vaccination. Serum and BAL fluid were tested for the presence of antibodies by ELISA test. Peripheral blood monomorphonuclear cells (PBMC) were isolated to quantify the number of IFN-γ secreting cells by ELISpot. Moreover, cytokine gene expression from the BAL fluid was performed. Total antibodies against M. hyopneumoniae and specific IgG were detected in serum of intradermally and intramuscularly (vaccine B only) vaccinated pigs at 4 and 8 weeks post-vaccination. M. hyopneumoniae specific IgA were detected in BAL fluid from vaccinated animals (Groups A and B) but not from controls and animals vaccinated with the bacterin D (padministration of an adjuvanted bacterin induces both systemic and mucosal immune responses. Moreover, the intramuscularly administered commercial vaccines each had a different ability to stimulate the immune response both systemically and locally. Copyright © 2013 Elsevier B.V. All rights reserved.

  18. Intravenous and Intramuscular Formulations of Antiseizure Drugs in the Treatment of Epilepsy.

    Science.gov (United States)

    Patel, Sima I; Birnbaum, Angela K; Cloyd, James C; Leppik, Ilo E

    2015-12-01

    Intravenous and intramuscular antiseizure drugs (ASDs) are essential in the treatment of clinical seizure emergencies as well as in replacement therapy when oral administration is not possible. The parenteral formulations provide rapid delivery and complete (intravenous) or nearly complete (intramuscular) bioavailability. Controlled administration of the ASD is feasible with intravenous but not intramuscular formulations. This article reviews the literature and discusses the chemistry, pharmacology, pharmacokinetics, and clinical use of currently available intravenous and intramuscular ASD formulations as well as the development of new formulations and agents. Intravenous or intramuscular formulations of lorazepam, diazepam, midazolam, and clonazepam are typically used as the initial treatment agents in seizure emergencies. Recent studies also support the use of intramuscular midazolam as easier than the intravenous delivery of lorazepam in the pre-hospital setting. However, benzodiazepines may be associated with hypotension and respiratory depression. Although loading with intravenous phenytoin was an early approach to treatment, it is associated with cardiac arrhythmias, hypotension, and tissue injury at the injection site. This has made it less favored than fosphenytoin, a water-soluble, phosphorylated phenytoin molecule. Other drugs being used for acute seizure emergencies are intravenous formulations of valproic acid, levetiracetam, and lacosamide. However, the comparative effectiveness of these for status epilepticus (SE) has not been evaluated adequately. Consequently, guidelines for the medical management of SE continue to recommend lorazepam followed by fosphenytoin, or phenytoin if fosphenytoin is not available. Intravenous solutions for carbamazepine, lamotrigine, and topiramate have been developed but remain investigational. The current ASDs were not developed for use in emergency situations, but were adapted from ASDs approved for chronic oral use. New

  19. Fibrous Myopathy as a Complication of Repeated Intramuscular Injections for Chronic Headache

    Directory of Open Access Journals (Sweden)

    R Burnham

    2006-01-01

    Full Text Available Two cases of fibrous myopathy associated with repeated, long-term intramuscular injections for treatment of chronic temporomandibular joint pain and chronic headache, respectively, are described. Both patients developed severe, function-limiting contractures in upper and lower extremity muscles used as injection sites. In one of the cases, the contractures were painful. Electrophysiological testing, magnetic resonance imaging and muscle biopsy results were all consistent with myopathy and replacement of skeletal muscle with noncontractile fibrous tissue. These cases are presented to increase awareness of fibrous myopathy and to promote surveillance for this serious potential complication of long-term intramuscular injections in chronic headache and other pain patients.

  20. Effect of genotype on fatty acid composition of intramuscular and subcutaneous fat of Celta pig breed

    Directory of Open Access Journals (Sweden)

    Domínguez, R.

    2014-09-01

    Full Text Available A total of 45 Celta breed pigs were used to investigate the effect of genotype (Barcina, Carballiña and Santiaguesa lines on the fatty acid composition of intramuscular (IMF and subcutaneous fat (SF. The total IMF content was influenced by genotype (P Un total de 45 cerdos de raza Celta fueron usados para estudiar el efecto del genotipo (líneas Barcina, Carballiña y Santiaguesa sobre la composición de ácidos grasos de la grasa intramuscular y subcutánea. El contenido en grasa intramuscular estuvo influenciado por el genotipo (P < 0.05; la Barcina presentó los mayores valores (5.21% vs 1.99 y 3.59 para las líneas Santiaguesa y Carballiña respectivamente. Los lípidos totales y neutros de la grasa intramuscular de la línea Santiaguesa mostraron mayores contenidos de PUFA que las otras dos líneas. Los índices nutricionales también se vieron influenciados por el genotipo; la línea Santiguesa presentó los menores valores de los índices aterogénico y trombogénico y los mayores de la relación entre ácidos grasos hipo e hipercolesterolémicos. En los lípidos totales y neutros de la grasa intramuscular se obtuvieron mayores valores de MUFA y menores de PUFA (P < 0.05 que en la grasa subcutánea. En los lípidos polares, las muestras de grasa intramuscular presentaron los mayores valores de PUFA (entre 37–44%. Finalmente, la grasa subcutánea mostró valores superiores de MUFA y SFA que la intramuscular (P < 0.05. Las diferencias en el contenido de grasa intramuscular y de espesor de grasa subcutánea implica que su deposición puede estar regulada por diferentes mecanismos.

  1. Pharmacokinetics of an ampicillin-sulbactam combination after intravenous and intramuscular administration to sheep.

    OpenAIRE

    Escudero, E; Espuny, A; Vicente, S; Cárceles, C M

    1999-01-01

    The pharmacokinetics of a 2:1 ampicillin-sulbactam combination were studied in 6 sheep, after intravenous and intramuscular injection at a single dose rate of 20 mg/kg body weight (13.33 mg/kg of sodium ampicillin and 6.67 mg/kg of sodium sulbactam). The drugs were distributed according to an open 2-compartment model after intravenous administration and a one-compartment model with first order absorption after intramuscular administration. The apparent volumes of distribution calculated by th...

  2. Effects of radiotherapy combined with daily intramuscular injection of bleomycin for uterine cervical cancer

    International Nuclear Information System (INIS)

    Ishigaki, Takeo; Sakuma, Sadayuki.

    1983-01-01

    A total of 103 cases of cancer of the uterine cervix, untreated previously, were treated with radiotherapy combined with daily intramuscular injection of Bleomycin 30 minutes before irradiation (BR therapy) in 12 institutions. Result showed that especially in cases of stage III, BR therapy was superior in primary local control rate (89.6%), recurrence rate (20.8%) and crude 5-year survival rate (56.5%) to that of nationwide statistics. No severe side effects were found. It was concluded that external radiotherapy could control advanced cancers of uterine cervix combining with intramuscular injection of Bleomycin. (author)

  3. Duration and degree of radioprotection by WR-2721 in mice following intraperitoneal, intramuscular and subcutaneous administration

    International Nuclear Information System (INIS)

    Kuna, P.

    1983-01-01

    An intramuscular dose of 300 mg S-2-(3-aminopropylamino)-ethyl-phosphothioic acid (WR-2721) per kg body weight, applied 15-120 minutes before whole-body #betta# irradiation, protected mice significantly from radiation death. The protective dose was 35% of the acute toxic dose. After intraperitoneal and subcutaneous injection, resp., the same protective dose was effective within a 90 minute interval. According to the LD/sub 50/30/ the most effective radioprotective dose in mice was 300 mg WR-2721/kg, applied intramuscularly

  4. Fatores considerados pela população como mais importantes para manutenção da saúde Factores considerados por la población como más importantes para el mantenimiento de la salud Factors considered important for health maintenance by the population

    Directory of Open Access Journals (Sweden)

    Fernando Vinholes Siqueira

    2009-12-01

    Full Text Available OBJETIVO: Analisar os fatores que adultos e idosos consideram como mais importantes para manutenção da saúde. MÉTODOS: Estudo transversal realizado com 4.060 adultos e 4.003 idosos residentes em áreas de abrangência de 240 unidades básicas de saúde das regiões Sul e Nordeste, em 2005. Um cartão com figuras e frases referentes a sete fatores relacionados com o risco de doenças e agravos não transmissíveis era mostrado aos indivíduos para que indicassem o fator mais relevante para a saúde. Os fatores eram: manter uma alimentação saudável, fazer exercício físico regularmente, não tomar bebidas alcoólicas em excesso, realizar consultas médicas regularmente, não fumar, manter o peso ideal e controlar ou evitar o estresse. As análises foram ajustadas por regressão de Poisson com cálculo de razões de prevalência ajustadas, intervalos com 95% de confiança, e valores de significância usando os Testes de Wald para heterogeneidade e tendência linear. RESULTADOS: Os fatores mais freqüentemente indicados pelos adultos foram: alimentação saudável (33,8%, realizar exercício físico (21,4% e não fumar (13,9%. Entre os idosos, os fatores mais relatados foram: alimentação saudável (36,7%, não fumar (17,7% e consultar o médico regularmente (14,2%. Foram observadas diferenças entre os fatores citados conforme a região geográfica, variáveis demográficas, socioeconômicas e de saúde. CONCLUSÕES: A maioria de adultos e idosos, de ambas regiões, reconhece e indica a necessidade de manter uma alimentação saudável e de não fumar como medidas mais importantes para manutenção da saúde. Estratégias de educação em saúde devem considerar essas características dos indivíduos para estimular medidas específicas a serem adotadas para cada segmento populacional.OBJETIVO: Analizar los factores que adultos y ancianos consideran como más importantes para mantenimiento de la salud. MÉTODOS: Estudio transversal

  5. Associations of heart and adipocyte fatty acid-binding protein gene expression with intramuscular fat content in pigs

    NARCIS (Netherlands)

    Gerbens, F.; Verburg, F.J.; Moerkerk, van H.T.; Engel, B.; Buist, W.; Veerkamp, J.H.; Pas, te M.F.

    2001-01-01

    Intramuscular fat content is a major determinant of meat quality in pigs. Previously, polymorphisms in the adipocyte and heart fatty acid-binding protein genes, A-FABP and H-FABP, have been significantly associated with genetic variation of intramuscular fat content in a Duroc pig population.

  6. Associations of heart and adipocyte fatty acid-binding protein gene expression with intramuscular fat content in pigs.

    NARCIS (Netherlands)

    Gerbens, F.; Verburg, F.J.; Moerkerk, H.T.B. van; Engel, B.; Buist, W.; Veerkamp, J.H.; Pas, M.F. te

    2001-01-01

    Intramuscular fat content is a major determinant of meat quality in pigs. Previously, polymorphisms in the adipocyte and heart fatty acid-binding protein genes, A-FABP and H-FABP, have been significantly associated with genetic variation of intramuscular fat content in a Duroc pig population.

  7. Cultura e desenvolvimento local: um estudo do Programa Bairro-Escola da cidade de Nova Iguaçu

    OpenAIRE

    Knopp, Glauco da Costa

    2008-01-01

    A relação entre cultura e desenvolvimento é um dos assuntos centrais dos debates contemporâneos que vão além do ambiente acadêmico e atinge a agenda política em diversos países. A cultura exerce um papel importante para o desenvolvimento que não se restringe à dimensão econômica, pois é capaz de construir ou reconstruir identidades, elevar a auto-estima individual e coletiva, adicionar valor ao patrimônio existencial humano. Faz-se necessário, ainda, um outro conceito de desenvolvimento, calc...

  8. Um exemplo de ironia socrática no Íon de Platão

    Directory of Open Access Journals (Sweden)

    Teodoro Rennó Assunção

    2015-12-01

    Full Text Available A partir da informação básica sobre a história do conceito de “ironia”, assim como da definição de “ironia socrática” por Gregory Vlastos em seu conhecido artigo “Socratic Irony”, este nosso breve artigo visa a fazer simplesmente um teste da proposição de G. Vlastos através de um estudo de caso da ironia socrática, comentando o seu exemplo mais importante em um diálogo menor de Platão: o Íon.

  9. A NOVA NARRATIVA ITALIANA UM AUTOR, UM SÍMBOLO: PIER VITTORIO TONDELLI

    Directory of Open Access Journals (Sweden)

    Lucia Sgobaro Zanette

    2016-01-01

    Full Text Available Na literatura italiana dos anos oitenta, uma série de autores produziram textos classificados pela crítica de a nova narrativa italiana. Pier Vittorio Tondelli, que escreveu romances, contos, crônicas, textos críticos e peças de teatro durante toda a década, tornou-se - com as suas temáticas inerentes a uma realidade pós-moderna e, principalmente, ligadas a certas experiências da juventude do final dos anos setenta até o começo dos anos noventa - um autor-ícone desse período. Com a sua maneira de viver como homem em movimento, seu agudo senso de observa- ção, sua escritura, seu estilo, seu ritmo e seu forte sentire, ele se revelou um símbolo dessa nova geração de escritores, que promoveram uma importante renovação da literatura italiana, libertando-a dos impasses que a condicionavam: a dificuldade de leitura da narrativa neovanguardista e experimental, a falta de espessura da literatura de consumo e a obviedade da literatura realista, que, todavia, os novos escritores valorizavam bastante. Palavras-chave: literatura italiana, anos oitenta, renovação.

  10. TDAH: um sintoma social

    Directory of Open Access Journals (Sweden)

    Giuliana Sorbara

    2017-03-01

    Full Text Available Ao longo da história médica a definição e a forma de se definir o diagnóstico do Transtorno do Déficit de Atenção e Hiperatividade (TDAH culminaram em uma medicalização excessiva e questionável de crianças participantes do cenário educacional. Essa medicalização da vida no ambiente escolar se realiza aliada a um processo histórico e social de normatização imposto pela biopolítica, e, consequentemente, um aumento de diagnósticos visando melhorar o desempenho do aluno. Christoph Türcke ao falar sobre os choques imagéticos auxilia na compreensão do TDAH. Para ele, o choque de imagens apresentadas pelos aparatos audiovisuais exerce uma fascinação estética que, ao fornecer sempre novas imagens, estabelece um espaço mental, em regime de atenção excessiva. Novos padrões de socialização, dessa forma, vão se sedimentando no que se pode denominar de uma mutação subjetiva ligada às imagens e, por conseguinte, medicalizada. Enfim, o TDAH encontra-se nesse espaço em que a criança que possui o déficit de atenção é a criança da cultura atual, denominada por cultura High-tech, em que os sintomas do TDAH são da sociedade contemporânea.

  11. Obesidade: um problema comportamental?

    Directory of Open Access Journals (Sweden)

    Jacira A. da Cunha

    Full Text Available Com o objetivo de comparar os efeitos de alguns componentes de programas comportamentais para redução do peso corporal e a manutenção do peso perdido, foram selecionados 19 sujeitos: dois homens e 17 mulheres. Foram designados aleatoriamente para uma das quatro condições experimentais: Peso e Registro Público mais dicas de Auto-Controle (PRP + DA; Peso e Registro Público mais Registro de Alimentação (PRP + RA; Peso e Registro Público (PRP e apenas Peso (P; Grupo de Controle. Os sujeitos fizeram um contrato de perder um quilo por semana. Com relação a este objetivo, durante o programa e follow-up, o desempenho do Grupo (A PRP + DA foi de 89,5%; do Grupo (B PRP + RA foi de 92,3%; do Grupo (C PRP foi de 60,0% e do Grupo (D P, foi de 42,3%. Foi encontrada uma diferença significativa entre as condições experimentais e o Grupo (D P, e uma variabilidade acentuada entre os sujeitos. Há evidência de que os sujeitos adquiriram um grau relativamente alto de auto-controle no comportamento de comer; o peso perdido foi mantido durante o follow-up de quatro meses. O experimento mostrou que certos componentes são mais eficientes com determinados sujeitos. E há sujeitos que perdem peso em- condições mínimas, como as condições do Grupo de Controle.

  12. Síndrome mão-pé induzida por quimioterapia: relato de um caso

    Directory of Open Access Journals (Sweden)

    Delma Aurélia da Silva Simão

    2012-04-01

    Full Text Available Objetivou-se relatar um caso de uma paciente que apresentou síndrome mão-pé de grau 3, decorrente do uso do quimioterápico Capecitabina e para a qual foi utilizada massagem local com creme hidratante aquoso à base de aloe vera. A capacidade funcional da paciente foi avaliada utilizando-se a Escala de Performance ECOG e as lesões fotografadas durante as consultas de enfermagem que ocorreram em intervalos de dez dias, totalizando quarenta dias de acompanhamento. Observou-se melhora significativa da integridade tissular, com regressão total dos sintomas, importante ganho em qualidade de vida, e retorno imediato ao tratamento quimioterápico. Acredita-se que o aloe vera pode ser um importante coadjuvante na assistência de enfermagem a pacientes submetidos à quimioterapia antineoplásica.

  13. Um gênero comunicacional: os boatos e as lendas urbanas

    OpenAIRE

    Université Paul Valéry/Montpelier III, Jean-Bruno Renard - Université Paul Valé

    2008-01-01

    Neste artigo, o autor pontua que é preciso analisar o grau de um boato na sociedade e estudar os mecanismos de distorção de fatos ou informações factuais. Para ele, no entanto, é muito importante entender como e por que são espalhadas notícias falsas que passam a merecer crédito. Renard acredita que boatos e narrativas populares contemporâneas são os equivalentes modernos de lendas antigas ao expressarem um pensamento social ou simbólico.

  14. Um estudo das relações interpessoais em famílias com farmacodependentes

    OpenAIRE

    Silva, Jair Lourenço; Macedo, Rosa Maria S.; Derntl, Alice Moreira; Bergami, Nancy Benedita Berrueso

    2007-01-01

    Este estudo tem como objetivo evidenciar as implicações dos padrões de humor na manutenção do ciclo da drogadicção nos sistemas familiares com dependentes químicos, tendo como pressupostos as correlações entre drogadicção e transtornos de humor. Consideramos importante investigar como os padrões de depressão e mania afetam e são afetados, recursivamente, pelo sistema familiar com membro adicto. Apresentamos um estudo de caso de terapia familiar estrutural e estratégica de uma família com um m...

  15. D. Luís Pires : retalhos de vida de um prelado quatrocentista

    OpenAIRE

    Garrido, André

    2007-01-01

    D. Luís foi capelão em 1433, quando D. Duarte subiu ao trono, e era arcebispo de Braga quando morreu em 1480. Ao longo destes 43 anos foi embaixador régio, legado papal na Alemanha, bispo em três dioceses nacionais e responsável por um dos sínodos diocesanos mais importantes para o período medieval. No contexto nacional, foi testemunha directa dos momentos políticos que conduzirama Alfarrobeira. Já no âmbito europeu, foi um privilegiado espectador do despontar da arte e cultura renascentista ...

  16. um caminho reflexivo de enfermeira generalista a especialistaformar no cuidar para o desenvolvimento na neonatologia

    OpenAIRE

    Sousa, Ana Sofia Sequeira Neves de

    2013-01-01

    Relatório de estágio Mestrado, Enfermagem de Saúde Infantil e Pediatria, 2013, Escola Superior de Enfermagem de Lisboa O desenvolvimento infantil é um foco de atenção do Enfermeiro Especialista em Saúde Infantil e Pediatria (EESIP). Actualmente a Enfermagem de Saúde Infantil confronta-se com importantes desafios resultantes da situação atual das crianças em Portugal. Devido ao avanço da medicina e tecnologia, existem um elevado número de crianças com necessidades especiais ou com ris...

  17. Florfenicol concentrations in milk of lactating cows postreated by intramuscular or intramammary routes

    Directory of Open Access Journals (Sweden)

    John Ruiz B

    2010-08-01

    Full Text Available intramammary administration to establish the optimum withdrawal time, therapeutic efficacy, and its influence on milk yield. Materials and method. Twelve healthy lactating Holstein cows were selected from the University of Antioquia’s teaching dairy herd (Colombia, were randomly assigned to a control (n=6 group or florfenicol (n=6 group that received 20 mg/kg of florfenicol by intramammary and intramuscular routes, with a 15 days washout period between treatments. Results. The Tmax and Cmax for the intramuscular route were 6 hoursand 2.86 mg/L respectively. The Tmax and Cmax for the intramammary route, were estimated at 0 hour and about 20000 mg/L respectively by extrapolated from regression line. The florfenicol elimination phase in milk had an average half-life of elimination (t½ of 19.8 hours and 4.9 hours for intramuscular and intramammary administration, respectively. The therapeutic efficacy only was reached by intramammary route, when minimal inhibitory concentration (M.I.C. of florfenicol by Stahphylococcus aureus, was used as reference value. There was no statistically significant difference in milk yield between treated and non-treated cows. Conclusions. According to these results, post-treatment milk withdrawal should be no less than 3 days for intramammary administration, and at least 7 days for intramuscular administration. The therapeutic efficacy only was reached by intramammary route. In addition, there was no statistically significant difference in milk yield between treated and nontreated cows.

  18. MMR vaccine in 14 months old children, intramuscular versus subcutaneous administration

    NARCIS (Netherlands)

    Lafeber AF; Klis FRM van der; Marzec AHJO; Labadie J; Ommen R van; Strieder TG; Berbers GAM; Utrecht Stichting Thuiszorg; Amersfoort Stichting Thuiszorg Eemland (STE),; LVO

    2001-01-01

    In this study we compared the recommended subcutaneous administration of the RIVM MMR vaccine with the intramuscular administration for both safety and immunogenicity. Study subjects were 14 months old children, living in Amersfoort or Utrecht, who were eligible for their first MMR vaccination.

  19. Magnetic resonance imaging in patients with claustrophobia: results of treatment with intramuscular clorazepate

    Energy Technology Data Exchange (ETDEWEB)

    Sallevelt, P.E.J.M. [Velp Hospital, Dept. of Radiology (Netherlands); Barentsz, J.O. [Dept. of Diagnostic Radiology, University Hospital Nijmegen St. Radboud (Netherlands); Hekster, Y.A. [Dept. of Clinical Pharmacy, University Hospital Nijmegen St. Radboud (Netherlands)

    1993-08-01

    Between July 1991 and April 1992 1125 patients were examined with MRI, 34 (3%) of whom were treated with 50 mg clorazepate intramuscularly because of severe claustrophobia. The examination was successfully completed in 31 patients (91%). Only minor side effects were observed. Clorazepate suppresses the symptoms of claustrophobia, allowing the MRI examination to proceed. (orig.)

  20. Application of hyperspectral imaging for characterization of intramuscular fat distribution in beef

    Science.gov (United States)

    In this study, a hyperspectral imaging system in the spectral region of 400–1000 nm was used for visualization and determination of intramuscular fat concentration in beef samples. Hyperspectral images were acquired for beef samples, and spectral information was then extracted from each single sampl...

  1. Intramuscular nerve distribution of the hamstring muscles: Application to treating spasticity.

    Science.gov (United States)

    Rha, Dong-Wook; Yi, Kyu-Ho; Park, Eun Sook; Park, Chunung; Kim, Hee-Jin

    2016-09-01

    The aim of this article is to elucidate the ideal sites for botulinum toxin injection by examining the intramuscular nerve distributions in the hamstring muscles. The hamstring muscles, biceps femoris, semitendinosus, and semimembranosus (10 specimens each) were stained by the modified Sihler method. The locations of the muscle origins, nerve entry points, and intramuscular arborized areas were recorded as percentages of the total distance from the line crossing the medial and lateral tibial condyles (0%) to the ischial tuberosity (100%). Intramuscular arborization patterns were observed at 15-30% and 50-60% for the biceps femoris, 25-40% and 60-80% for the semitendinosus, and 20-40% for the semimembranosus. This study suggests that botulinum toxin injection for spasticity of the hamstring muscles should be targeted to specific areas. These areas, where the arborization of intramuscular nerve branches is maximal, are recommended as the most effective and safest points for injection. Clin. Anat. 29:746-751, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  2. EFFECT OF INTRAMUSCULAR ADMINISTRATION OF THIAZINAMIUM AND INHALED HISTAMINE ON FORCED INSPIRATORY VOLUME IN 1 S

    NARCIS (Netherlands)

    GIMENO, F; VANALTENA, R

    1993-01-01

    Twenty-one patients with symptoms suggestive of asthma were evaluated clinically by allergy skin tests, pulmonary function, and histamine inhalation challenge. In addition to the forced expiratory manoeuvres (FEV1), forced inspiratory manoeuvres (FIV1), were performed before and after intramuscular

  3. Intramuscular and intradermal injection of capsaicin: a comparison of local and referred pain

    DEFF Research Database (Denmark)

    Witting, Nanna; Svensson, Peter; Gottrup, Hanne

    2000-01-01

    The present study compared capsaicin-induced muscle and skin pain in humans. Twelve healthy subjects received, in a randomised, balanced order, 3 intramuscular (i.m.) injections into the brachioradial muscle: capsaicin 100 microg/1 ml, capsaicin 100 microg/20 microl or 1 ml solvent (Tween 80...

  4. Role of ultrasonography and magnetic resonance imaging in the diagnosis of intramuscular cysticercosis

    Energy Technology Data Exchange (ETDEWEB)

    Tripathy, Sujit Kumar [Postgraduate Institute of Medical Education and Research, Department of Orthopedics, Chandigarh (India); Friarage Hospital, Department of Orthopedics, Northallerton (United Kingdom); Sen, Ramesh Kumar; Akkina, Narendranadh; Hampannavar, Aravind; Tahasildar, Naveen [Postgraduate Institute of Medical Education and Research, Department of Orthopedics, Chandigarh (India); Limaye, Rajiv [Friarage Hospital, Department of Orthopedics, Northallerton (United Kingdom)

    2012-09-15

    Nonspecific clinical presentations often lead to misdiagnosis of focal cysticercal myositis. This report emphasizes the role of ultrasonography and magnetic resonance imaging (MRI) in the diagnosis of solitary intramuscular cysticercosis. Six patients with persistent post-traumatic isolated muscular swelling were treated with analgesic and antibiotics, but the swelling did not subside. Radiographs showed soft tissue swelling with no bony abnormalities. Laboratory markers were inconclusive. Ultrasonographic and magnetic resonance images (MRI) showed typical features of intramuscular cysticercosis. Clinical, radiological, and fundoscopic evaluation of brain and eyes could not isolate any cysticercosis focus in these organs. Patients were treated with 3 weeks albendazole therapy. The identifying sonographic features of intramuscular cysticercosis, as evident from this case series, included an intramuscular elliptical or oval anechoic lesion with echogenic intralesional focus likely to be scolex. Magnetic resonance images showed orientation of the cyst along the direction of muscle fibers with T2W hyperintense signal and post-contrast perilesional enhancement. All patients responded to medical treatment. Cysticercosis may manifest as isolated muscular swelling without neurological or ocular involvement. Clinicians should be aware of this clinical condition to avoid misdiagnosis. Ultrasonography and magnetic resonance imaging are good diagnostic aids to establish soft tissue cysticercosis. (orig.)

  5. Cyanide Antidotes for Mass Casualties: Comparison of Intramuscular Injector by Autoinjector, Intraosseous Injection, and Inhalational Delivery

    Science.gov (United States)

    2015-12-01

    Public Release; Distribution Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT Current antidotes for cyanide poisoning must be administered by intravenous... Cyanide Poisoning ; Intramuscular Injection; Intraosseous Injection; Inhalational Delivery 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT...required in cyanide - poisoned victims, since they may be hypotensive with collapsed peripheral veins. Thus, intravenous antidote administration would not

  6. Acute effects of intramuscular aponeurotomy on rat GM: Force transmission, muscle force and sarcomere length

    NARCIS (Netherlands)

    Jaspers, R.T.; Brunner, R.; Pel, J.J.M.; Huijing, P.A.J.B.M.

    1999-01-01

    Acute effects of intramuscular aponeurotomy on muscle force and geometry as a function to muscle length were studied in rat m. gastrocnemius medialis (GM). Acutely after aponeurotomy, activation of the muscle at increasing lengths (acute trajectory) showed a spontaneous and progressive but partial

  7. The experience of intramuscular benzathine penicillin for prophylaxis of recurrent cellulitis: A cohort study

    Directory of Open Access Journals (Sweden)

    Hsien-Meng Chen

    2017-10-01

    Conclusion: Intramuscular benzathine penicillin at a 4-week interval may be an effective prophylactic strategy to reduce the incidence of cellulitis. Further studies are necessary to determine the factors associated with failure of prophylaxis as well as optimal individualized dosage and dosing interval of the prophylactic agent.

  8. Arm flexion during ultrasound assists localization of an intramuscular etonogestrel contraceptive implant.

    Science.gov (United States)

    Biskamp, Connor; Kauffman, Robert P

    2016-03-01

    A nonpalpable etonogestrel implant was identified by high-frequency ultrasound in the biceps muscle 4-6mm below the skin. Active elbow flexion resulted in proximal movement of the implant relative to the ultrasound probe, suggesting localization in the muscle. This maneuver may assist in verifying intramuscular placement prior to surgical excision. Copyright © 2016 Elsevier Inc. All rights reserved.

  9. Role of ultrasonography and magnetic resonance imaging in the diagnosis of intramuscular cysticercosis

    International Nuclear Information System (INIS)

    Tripathy, Sujit Kumar; Sen, Ramesh Kumar; Akkina, Narendranadh; Hampannavar, Aravind; Tahasildar, Naveen; Limaye, Rajiv

    2012-01-01

    Nonspecific clinical presentations often lead to misdiagnosis of focal cysticercal myositis. This report emphasizes the role of ultrasonography and magnetic resonance imaging (MRI) in the diagnosis of solitary intramuscular cysticercosis. Six patients with persistent post-traumatic isolated muscular swelling were treated with analgesic and antibiotics, but the swelling did not subside. Radiographs showed soft tissue swelling with no bony abnormalities. Laboratory markers were inconclusive. Ultrasonographic and magnetic resonance images (MRI) showed typical features of intramuscular cysticercosis. Clinical, radiological, and fundoscopic evaluation of brain and eyes could not isolate any cysticercosis focus in these organs. Patients were treated with 3 weeks albendazole therapy. The identifying sonographic features of intramuscular cysticercosis, as evident from this case series, included an intramuscular elliptical or oval anechoic lesion with echogenic intralesional focus likely to be scolex. Magnetic resonance images showed orientation of the cyst along the direction of muscle fibers with T2W hyperintense signal and post-contrast perilesional enhancement. All patients responded to medical treatment. Cysticercosis may manifest as isolated muscular swelling without neurological or ocular involvement. Clinicians should be aware of this clinical condition to avoid misdiagnosis. Ultrasonography and magnetic resonance imaging are good diagnostic aids to establish soft tissue cysticercosis. (orig.)

  10. Fluorine-18 fluorodeoxyglucose positron emission tomography-computed tomography in evaluation of residual intramuscular myxoma

    International Nuclear Information System (INIS)

    Zade, Anand; Ahire, Archana; Shetty, Shishir; Rai, Sujith; Bokka, Rajashekharrao; Velumani, Arokiaswamy; Kabnurkar, Rasika

    2015-01-01

    Intramuscular myxoma (IM) is a rare benign neoplasm. In a patient diagnosed with IM of left thigh, we report the utility of a postoperative fluorine-18 fluorodeoxyglucose positron emission tomography-computed tomography scan in assessing the efficacy of surgical excision

  11. Freud: um monista mentalista?

    Directory of Open Access Journals (Sweden)

    Cândido Carla Laino

    2003-01-01

    Full Text Available É possível conceber a mente como um processo que emerge do corpo sem que possa ser reduzida a ele? Argumentamos que, ao situar as operações cerebrais mais próximas do terreno do significado, Freud desenvolve uma perspectiva energética do psiquismo que, além de se aproximar da moderna teoria científica da complexidade auto-organizada, é capaz de questionar as definições e categorias dualistas que tradicionalmente são aplicadas à relação mente-corpo. Com isso, Freud nos permite pensar em um corpo vivencial e multidimensional que difere do corpo abstrato da Modernidade, paradigmático ainda hoje para a maior parte das ciências que pesquisam o comportamento humano. A partir daí concluímos que, embora haja uma clara hegemonia do conhecimento biológico no estudo da mente, a contribuição freudiana que aponta a impossibilidade de traduzirmos completamente nossa experiência corporal em linguagem não pode ser ignorada, pois permite a conquista de uma nova racionalidade.

  12. Freud: um monista mentalista?

    Directory of Open Access Journals (Sweden)

    Carla Laino Cândido

    Full Text Available É possível conceber a mente como um processo que emerge do corpo sem que possa ser reduzida a ele? Argumentamos que, ao situar as operações cerebrais mais próximas do terreno do significado, Freud desenvolve uma perspectiva energética do psiquismo que, além de se aproximar da moderna teoria científica da complexidade auto-organizada, é capaz de questionar as definições e categorias dualistas que tradicionalmente são aplicadas à relação mente-corpo. Com isso, Freud nos permite pensar em um corpo vivencial e multidimensional que difere do corpo abstrato da Modernidade, paradigmático ainda hoje para a maior parte das ciências que pesquisam o comportamento humano. A partir daí concluímos que, embora haja uma clara hegemonia do conhecimento biológico no estudo da mente, a contribuição freudiana que aponta a impossibilidade de traduzirmos completamente nossa experiência corporal em linguagem não pode ser ignorada, pois permite a conquista de uma nova racionalidade.

  13. Um Historiador Cineasta

    Directory of Open Access Journals (Sweden)

    Miguel Mesquita Duarte

    2016-02-01

    Full Text Available No seu novo livro intitulado Jean-Luc Godard, Cinema Historian (2013, Michael Witt aborda alguns dos mais complexos e importantes aspectos da multifacetada obra de Jean-Luc Godard. Partindo de Histoire(s du Cinéma (1998 como objecto de estudo central, Michael Witt evidencia as proposições históricas aí desenvolvidos e analisa as suas formas, temas e procedimentos através da contextualização dos filmes e dos vídeos criados pelo cineasta Francês ao longo do projecto. Esta recensão crítica centra-se no estudo levado a cabo por Michael Witt sobre as principais influências e metodologias da investigação histórica de Godard, conferindo particular destaque ao encontro dialógico entre Godard e Walter Benjamin. Os modos alternativos de escrita da história convergem com a utilização criativa da montagem e com a exploração das capacidades intuitivas e expressivas da imagem, permitindo ao espectador entrar numa relação subjectiva com o passado. E, no caso de Godard, isso irá orientá-lo em direcção a uma reformulação da sintaxe fílmica e à consequente amplificação das potencialidades do cinema em narrar a história.

  14. Differences in intramuscular vascular connections of human and dog latissimus dorsi muscles.

    Science.gov (United States)

    Yang, D; Morris, S F

    1999-02-01

    Distal ischemia and necrosis of the dog latissimus dorsi muscle flap used in experimental cardiomyoplasty have been reported. However, little information on the intramuscular vascular anatomy of the dog latissimus dorsi is available. It is unclear whether there are any anatomic factors relating to the muscle flap ischemia and necrosis, and whether the dog latissimus dorsi is a suitable experimental model. To study the intramuscular vascular territories in the dog latissimus dorsi muscle, and to compare the intramuscular vasculature of the dog with that of the human, 5 fresh dog cadavers and 7 fresh human cadavers were injected with a mixture of lead oxide, gelatin, and water (200 mL/kg) through the carotid artery. Both the dog and the human latissimus dorsi muscles and neurovascular pedicles were dissected and radiographed. The intramuscular vascular anatomy of the latissimus dorsi muscles was compared. Radiographs demonstrate clearly that the pattern of latissimus dorsi intramuscular anastomoses between branches of the thoracodorsal artery and the perforators of posterior intercostal arteries in the proximal half of the muscle are different between the dog and the human. In the dog muscle, vascular connections between the thoracodorsal artery and the posterior intercostal arteries are formed by reduced-caliber choke arteries, whereas four to six true anastomoses without a change in caliber between them are found in the human muscle. The portion of the latissimus dorsi muscle supplied by the dominant thoracodorsal vascular territory was 25.9% +/- 0.3% in the dog and 23.9% +/- 0.5% in the human. For further comparison, an extended vascular territory in the latissimus dorsi muscle was demonstrated, including both the thoracodorsal territory and the posterior intercostal territories. The area of the extended vascular territory was 52% +/- 0.5% of the total muscle. The dog latissimus dorsi model may not be a perfect predictor of the behavior of the human latissimus

  15. Intramuscular Cobinamide Sulfite in a Rabbit Model of Sub-Lethal Cyanide Toxicity

    Science.gov (United States)

    Brenner, Matthew; Kim, Jae G.; Mahon, Sari B.; Lee, Jangwoen; Kreuter, Kelly A.; Blackledge, William; Mukai, David; Patterson, Steve; Mohammad, Othman; Sharma, Vijay S.; Boss, Gerry R.

    2009-01-01

    Objective To determine the ability of an intramuscular cobinamide sulfite injection to rapidly reverse the physiologic effects of cyanide toxicity. Background Exposure to cyanide in fires and industrial exposures and intentional cyanide poisoning by terrorists leading to mass casualties is an ongoing threat. Current treatments for cyanide poisoning must be administered intravenously, and no rapid treatment methods are available for mass casualty cyanide exposures. Cobinamide is a cobalamin (vitamin B12) analog with an extraordinarily high affinity for cyanide that is more water-soluble than cobalamin. We investigated the use of intramuscular cobinamide sulfite to reverse cyanide toxicity induced physiologic changes in a sublethal cyanide exposure animal model. Methods New Zealand white rabbits were given 10 mg sodium cyanide intravenously over 60 minutes. Quantitative diffuse optical spectroscopy and continuous wave near infrared spectroscopy monitoring of tissue oxy- and deoxyhemoglobin concentrations were performed concurrently with blood cyanide level measurements and cobinamide levels. Immediately after completion of the cyanide infusion, the rabbits were injected intramuscularly with cobinamide sulfite (n=6) or inactive vehicle (controls, n=5). Results Intramuscular administration led to rapid mobilization of cobinamide and was extremely effective at reversing the physiologic effects of cyanide on oxyhemoglobin and deoxyhemoglobin extraction. Recovery time to 63% of their baseline values in the central nervous system was in a mean of 1032 minutes in the control group and 9 minutes in the cobinamide group with a difference of 1023 minutes (95% confidence interval [CI] 116, 1874 minutes). In muscle tissue, recovery times were 76 and 24 minutes with a difference of 52 minutes (95% CI 7, 98min). Red blood cell cyanide levels returned towards normal significantly faster in cobinamide sulfite-treated animals than in control animals. Conclusions Intramuscular

  16. Effect of Salted Ice Bags on Surface and Intramuscular Tissue Cooling and Rewarming Rates.

    Science.gov (United States)

    Hunter, Eric J; Ostrowski, Jennifer; Donahue, Matthew; Crowley, Caitlyn; Herzog, Valerie

    2016-02-01

    Many researchers have investigated the effectiveness of different cryotherapy agents at decreasing intramuscular tissue temperatures. However, no one has looked at the effectiveness of adding salt to an ice bag. To compare the cooling effectiveness of different ice bags (wetted, salted cubed, and salted crushed) on cutaneous and intramuscular temperatures. Repeated-measures counterbalanced design. University research laboratory. 24 healthy participants (13 men, 11 women; age 22.46 ± 2.33 y, height 173.25 ± 9.78 cm, mass 74.51 ± 17.32 kg, subcutaneous thickness 0.63 ± 0.27 cm) with no lower-leg injuries, vascular diseases, sensitivity to cold, compromised circulation, or chronic use of NSAIDs. Ice bags made of wetted ice (2000 mL ice and 300 mL water), salted cubed ice (intervention A; 2000 mL of cubed ice and 1/2 tablespoon of salt), and salted crushed ice (intervention B; 2000 mL of crushed ice and 1/2 tablespoon of salt) were applied to the posterior gastrocnemius for 30 min. Each participant received all conditions with at least 4 d between treatments. Cutaneous and intramuscular (2 cm plus adipose thickness) temperatures of nondominant gastrocnemius were measured during a 10-min baseline period, a 30-min treatment period, and a 45-min rewarming period. Differences from baseline were observed for all treatments. The wetted-ice and salted-cubed-ice bags produced significantly lower intramuscular temperatures than the salted-crushed-ice bag. Wetted-ice bags produced the greatest temperature change for cutaneous tissues. Wetted- and salted-cubed-ice bags were equally effective at decreasing intramuscular temperature at 2 cm subadipose. Clinical practicality may favor salted-ice bags over wetted-ice bags.

  17. Contenidos de isómeros trans de los ácidos grasos en productos cárnicos. (III Tejido adiposo y grasa intramuscular de vacuno

    Directory of Open Access Journals (Sweden)

    Lluch, M. C.

    1993-06-01

    polinsaturados, en el tejido muscular. Los contenidos de ácidos grasos trans muestran diferencias significativas entre ambos tejidos (medias del 7% de ácidos trans totales en grasa intramuscular y 10.5% en grasa de depósito. El C18: 1t presenta una distribución paralela a la del total de ácidos trans, mientras que para el C16: 1 trans se observa un comportamiento claramente diferente, ya que no se presentan estas diferencias significativas entre ambos tejidos. En cuanto a los factores estudiados que pueden influir en el contenido de isómeros trans, cabe destacar que la raza fue aquél que ofrecía más diferencias, mientras que entre los diversos orígenes (explotaciones ganaderas y entre categorías de canal se presentaron menos diferencias en relación a los contenidos de estos isómeros. También es importante destacar que las correlaciones que se han observado entre los contenidos de ácidos trans y los totales de ácidos saturados, mono y polinsaturados presentan un signo contrario, según el tipo de tejido. Así, un aumento del % de ácidos trans va aparejado con un aumento de saturados y una disminución de polinsaturados en el tejido muscular, mientras que va aparejado con una disminución de saturados y un aumento de mono y polinsaturados en el tejido adiposo.

  18. Construção e caracterização de um transformador de 562,5 VA com núcleo de ferro amorfo

    OpenAIRE

    Maurício, André Filipe da Silva

    2014-01-01

    Nos sistemas de geração, transmissão e distribuição de energia, os transformadores de potência são um dos componentes mais comuns e importantes. Deste modo, o desempenho dos transformadores é fundamental para a eficiência global dos sistemas. Para optimizar a eficiência dos transformadores, a escolha do material ferromagnético a usar para a construção do núcleo, é um factor muito importante. Por exemplo, o uso de um material ferromagnético amorfo no núcleo de um transformador, em vez de aço s...

  19. Características sociodemográficas e fatores importantes para a manutenção da saúde em mulheres

    Directory of Open Access Journals (Sweden)

    Márcia Cristina Sales

    2014-12-01

    Full Text Available Objetivo: Investigar fatores importantes para a manutenção da saúde e as características socioeconômicas e demográficas de mulheres usuárias de Unidades Básicas de Saúde. Métodos: Estudo observacional, transversal e analítico, realizado em 2011, envolvendo 204 mulheres assistidas em 16 unidades do município de Queimadas, Paraíba. Obtiveram-se informações referentes às características demográficas (local de moradia, cor da pele, idade e situação conjugal, socioeconômicas (nível de escolaridade e recebimento do Bolsa Família, e hábitos de vida (alimentação, tabagismo, consulta médica, sedentarismo, ingestão de bebidas alcoólicas, controle do peso e do estresse por meio de questionário, ao qual aplicou-se estatística descritiva e razão de prevalência. Resultados: As participantes apresentaram idade média de 28,22 anos (DP=6,49. A maioria residia na zona rural (n=126; 61,76%, declarou saber ler ou escrever (n=184; 90,2% e receber o benefício Bolsa Família (n=153; 75,0%. Os fatores mais importantes para a manutenção da saúde foram a alimentação saudável (n=126; 61,8%, o não tabagismo (n=21; 10,3% e a consulta médica regular (n=19; 9,3%. As variáveis socioeconômicas e demográficas não apresentaram associações estatísticas significativas com os fatores importantes para manutenção da saúde. Conclusão: A população estudada reconhece a alimentação saudável, o não tabagismo e as consultas médicas regulares como os fatores mais importantes para a manutenção da saúde.

  20. Caso clínico radiológico fecaloma : importante complicación en adultos mayores con constipación crónica

    OpenAIRE

    Andrés O´Brien, S.

    2012-01-01

    La constipación crónica es un síntoma de alta frecuencia en la población, siendo uno de los principales motivos de consulta gastroenterológica. Su prevalencia puede ser muy alta en adultos mayores, en especial a nivel de asilos, donde alcanza un 80%. Una de las complicaciones más importante es la Impactación Fecal o Fecaloma, que puede determinar la formación de úlceras estercoráceas y eventualmente perforación, con una alta morbimortalidad. Se presenta un caso de un gran fecaloma en paciente...

  1. Gestión del conocimiento, aprendizaje organizacional y psicología cognitiva: desentrañando importantes competencias individuales y organizacionales

    OpenAIRE

    PAUL R. SPARROW

    2002-01-01

    El principal objetivo de este artículo es atraer la atención de los psicólogos del trabajo sobre una gama de competencias necesarias para actuar de forma eficaz en los diseños de las organizaciones modernas. Entender la naturaleza de estas capacidades individuales y organizacionales resulta ahora más importante para los psicólogos del trabajo y de las organizaciones porque las organizaciones de trabajo modernas funcionan en un contexto que cambia con rapidez. Hoy en día las organizaciones se...

  2. Kinetics of sup(99m)Tc-EHDP administered by intramuscular injection in man and in experimental animals

    International Nuclear Information System (INIS)

    Vattimo, A.; Lore, F.; Pisani, M.

    1981-01-01

    With the aim of assessing the kinetics of a diphosphonate administered by intramuscular injection, we have studied the behaviour of sup(99m)Tc-labelled 1-hydroxy-1, 1-diphosphonate in man and in experimental animals, after intramuscular injection. The curves of plasma and urine radioactivity were analyzed in a six-compartment kinetic model containing seven transition coefficients. The results show that the diphosphonate given by intramuscular injection is absorbed rapidly and completely. Therefore the possibility of using this way of administration should be considered in the pathological conditions in which diphosphonates are used as therapeutic agents. (orig.) [de

  3. Avaliação da buprenorfina pelas vias intravenosa ou intramuscular em cães anestesiados pelo desfluorano

    Directory of Open Access Journals (Sweden)

    Souza Almir Pereira de

    2004-01-01

    Full Text Available Objetivou-se avaliar comparativamente os efeitos da buprenorfina, administrada pelas vias intramuscular(IM ou intravenosa (IV, sobre variáveis cardiovasculares, em cães anestesiados com desfluorano. Para tanto, foram utilizados dezesseis cães adultos, clinicamente saudáveis, distribuídos em dois grupos (n=8 denominados de GI e GII. Em ambos os grupos, a anestesia foi induzida com propofol (8 mg/kg, IV e em seguida os animais foram intubados com sonda orotraqueal de Magill, a qual foi conectada ao aparelho de anestesia volátil para administração de desfluorano (1,5 CAM. Após 30 minutos do início da anestesia inalatória, foi aplicado no GI buprenorfina na dose de 0,02 mg/kg pela via IV, enquanto no GII administrou-se o opióide na mesma dose porém pela via IM. Avaliaram-se: freqüência cardíaca (FC; pressões arteriais sistólica, diastólica e média (PAS, PAD e PAM; débito cardíaco (DC; pressão venosa central (PVC e pressão da artéria pulmonar (PAP. As colheitas foram feitas nos seguintes momentos: M1 - 30 minutos após o início da anestesia inalatória antes da aplicação do opióide; M2 - 15 minutos após a administração da buprenorfina; M3, M4 e M5 - de 15 em 15 minutos após M2. A avaliação estatística dos dados foi efetuada por meio de Análise de Perfil (p<0,05. As variáveis PAS, PAM, DC, PVC e PAP, não apresentaram alterações significativas de seus valores em ambos os grupos. Entretanto, a FC e a PAD apresentaram reduções significativas após a administração do opióide apenas no GI. Assim, pôde-se concluir que a buprenorfina administrada pelas vias IV ou IM não interferiu nos índices cardiovasculares de forma a manifestar efeitos clínicos importantes em cães anestesiados com desfluorano.

  4. EMPLOYABILITY van UM-afgestudeerden

    NARCIS (Netherlands)

    van Eldert, Peter; Künn, Annemarie; Mommers, Ardi

    2017-01-01

    De voor u liggende studie is een weerslag van het project ‘Employability onder UM afgestudeerden’. Het rapport geeft eerst een samenvatting van de uitgevoerde literatuurstudie op het gebied van ‘employability’ in het hoger onderwijs. Vervolgens wordt de ‘employability’ van UM afgestudeerden vijf

  5. Parâmetros Ecocardiográficos e Sobrevida na Cardiopatia Chagásica com Disfunção Sistólica Importante

    Directory of Open Access Journals (Sweden)

    Daniela do Carmo Rassi

    2014-04-01

    Full Text Available Fundamento: O ecocardiograma fornece dados importantes na avaliação cardiológica de pacientes em insuficiência cardíaca. A identificação de parâmetros ecocardiográficos na cardiopatia chagásica grave auxiliaria na implementação terapêutica e na avaliação prognóstica. Objetivo: Correlacionar parâmetros ecocardiográficos com desfecho mortalidade cardiovascular em pacientes com fração de ejeção 70,71 mL/m2 foi associado ao aumento significativo na mortalidade (log rank p < 0,0001. Conclusão: O volume indexado do átrio esquerdo mostrou-se como único fator de predição independente de mortalidade nesta população de pacientes chagásicos e com disfunção sistólica importante.

  6. Um novo futuro

    Directory of Open Access Journals (Sweden)

    Luiz Carlos Mendonça de Barros

    2008-07-01

    Full Text Available Para explicar o dinamismo da economia brasileira nos últimos anos, é preciso entender as mudanças na economia mundial, principalmente na Ásia. A incorporação de quase um bilhão de asiáticos à economia de mercado provocou uma alteração profunda nas relações de preços entre produtos industriais e commodities agrícolas e minerais, em favor destes últimos. Essa nova dinâmica de preços nos mercados mundiais provocou uma mudança nas contas de nosso comércio exterior, com o aparecimento, a partir de 2004, de saldos comerciais elevadíssimos.To understand the dynamics of Brazilian economy in recent years, one has to assimilate the changes in the world economy, mainly in Asia. The incorporation of almost a billion of Asians into the market economy led to a profound change in the relations of prices between industrial products and mineral and agricultural commodities, in favour of the latter. This new dynamic of prices in international markets had an impact over our external commerce, resulting, since 2004, in very high incomes.

  7. A physiologically based pharmacokinetics model for florfenicol in crucian carp and oral-to-intramuscular extrapolation.

    Science.gov (United States)

    Yang, F; Sun, N; Sun, Y X; Shan, Q; Zhao, H Y; Zeng, D P; Zeng, Z L

    2013-04-01

    In this study, an oral physiologically based pharmacokinetics (PBPK) model was developed for florfenicol in crucian carp (Carassius auratus). Subsequently, oral-to-intramuscular extrapolation was performed and the two models were used to predict florfenicol concentrations in the edible tissues of crucian carp. The oral model gave good predictions in most tissues, except for kidney and liver in which the florfenicol concentrations were underestimated at the later time points. In contrast, using the intramuscular model, the concentrations in the kidney were overestimated at the later time points. Both models had the best predictive ability in the main edible tissue, the muscle. The oral model also accurately predicted the florfenicol concentrations in the muscle after multiple doses. The present study demonstrated the feasibility of predicting florfenicol concentrations in the edible tissues of crucian carp using a route-to-route extrapolation method. © 2012 Blackwell Publishing Ltd.

  8. First intramuscular administration in the U.S. space program. [of motion sickness drugs

    Science.gov (United States)

    Bagian, James P.

    1991-01-01

    In the past, the only kind of medicines used for symptomatic treatment of space motion sickness (SMS) in space had been oral, transdermal, or suppositories. This paper describes the effect of the first intramuscular (IM) administration of Phenergan (50-mg in single dose) on SMS in one subject who exhibited grade-3 symptoms and signs which persisted unabated throughout the first and the second flight days aboard the Space Shuttle. Thirty minutes after the injection, the subject had completely recovered. His symptoms were gone, his appetite was back, and he had no recurrences for the remainder of the flight. Since that experiment, intramuscular injections have been given nine more times on subsequent flights, with similar results.

  9. Radiological Characteristics and Management of Intramuscular Myxoma of the Temporal Muscle: Case Report

    Science.gov (United States)

    HIGASHIDA, Tetsuhiro

    2014-01-01

    The patient was a 51-year-old male with a 3-year history of a slow-growing, asymptomatic, subcutaneous mass in the left temporal region. Magnetic resonance imaging revealed a well-defined extracranial lesion with heterogeneous enhancement and without invasion of the skull. A variety of soft tissue tumors were included in the differential diagnosis. The patient underwent total resection of the tumor, and a diagnosis of intramuscular myxoma was confirmed histologically. There was no evidence of recurrence at 6-month follow-up. The present case is the first characterization of the radiological appearance of intramuscular myxoma in the temporal muscle. I emphasize that increased awareness of this rare lesion and a careful clinical and radiological preoperative assessment are crucial in determining an appropriate treatment strategy for patients with a soft tissue tumor of the head. PMID:24418787

  10. Distribution of enrofloxacin in intestinal tissue and contents of healthy pigs after oral and intramuscular administrations

    DEFF Research Database (Denmark)

    Wiuff, C.; Lykkesfeldt, J.; Aarestrup, Frank Møller

    2002-01-01

    and colon from pigs killed at 2, 3 and 6 h after dosing. Intramuscular administration resulted in significantly higher concentrations in plasma, intestinal tissue and lymph nodes at 2 h but not at 3 or 6 h compared with p.o. administration. The absorption and distribution phase was longer after oral......The concentration of enrofloxacin in plasma, intestinal tissue, lymph nodes and intestinal contents was investigated in healthy pigs after oral (p.o.) and intramuscular (i.m.) administration of a single dose of 2.5 mg/kg bw. Tissue and content samples were collected from jejunum, ileum, caecum...... administration, and maximum concentrations in tissue and plasma were determined later than after i.m. administration. No difference between route of administration was observed in the intestinal content. Enrofloxacin concentrations in faeces during a 5-day dosing regimen with i.m. and p.o. administration were...

  11. Sequential decoding of intramuscular EMG signals via estimation of a Markov model.

    Science.gov (United States)

    Monsifrot, Jonathan; Le Carpentier, Eric; Aoustin, Yannick; Farina, Dario

    2014-09-01

    This paper addresses the sequential decoding of intramuscular single-channel electromyographic (EMG) signals to extract the activity of individual motor neurons. A hidden Markov model is derived from the physiological generation of the EMG signal. The EMG signal is described as a sum of several action potentials (wavelet) trains, embedded in noise. For each train, the time interval between wavelets is modeled by a process that parameters are linked to the muscular activity. The parameters of this process are estimated sequentially by a Bayes filter, along with the firing instants. The method was tested on some simulated signals and an experimental one, from which the rates of detection and classification of action potentials were above 95% with respect to the reference decomposition. The method works sequentially in time, and is the first to address the problem of intramuscular EMG decomposition online. It has potential applications for man-machine interfacing based on motor neuron activities.

  12. Comparison of oral and intramuscular recombinant canine distemper vaccination in African wild dogs (Lycaon pictus).

    Science.gov (United States)

    Connolly, Maren; Thomas, Patrick; Woodroffe, Rosie; Raphael, Bonnie L

    2013-12-01

    A series of three doses of recombinant canary-pox-vectored canine distemper virus vaccine was administered at 1-mo intervals, orally (n = 8) or intramuscularly (n = 13), to 21 previously unvaccinated juvenile African wild dogs (Lycaon pictus) at the Wildlife Conservation Society's Bronx Zoo. Titers were measured by serum neutralization at each vaccination and at intervals over a period of 3.5-21.5 mo after the initial vaccination. All postvaccination titers were negative for orally vaccinated animals at all sampling time points. Of the animals that received intramuscular vaccinations, 100% had presumed protective titers by the end of the course of vaccination, but only 50% of those sampled at 6.5 mo postvaccination had positive titers. None of the three animals sampled at 21.5 mo postvaccination had positive titers.

  13. Transient erectile dysfunction associated with intramuscular injection of botulinum toxin type A.

    Science.gov (United States)

    Papadonikolakis, Anastasios S; Vekris, Marios D; Kostas, John P; Korompilias, Anastasios V; Soucacos, Panayotis N

    2002-01-01

    Autonomic nervous system dysfunction occurs rarely after botulinum toxin type A (BTX-A) intramuscular injections. We report a case of a 23-year-old man with spastic diplegia who had transient erectile dysfunction after intramuscular injection of BTX-A (total dosage, 300 IU, body weight 95 kg) in both hamstring muscles. Some investigators believe that the local spread of the toxin is responsible for autonomic dysfunction, while others believe that the transportation of the toxin to the spinal cord via retrograde flow or via the blood flow after entering the circulation are possible mechanisms of neurologic side effects. On the basis of our case, a retrograde axoplasmic flow to the spinal cord could probably occur because the spinal cord level of hamstring muscles is close to spinal cord levels responsible for erection control.

  14. Pharmacokinetics of ketoprofen in the green iguana (Iguana iguana) following single intravenous and intramuscular injections.

    Science.gov (United States)

    Tuttle, Allison D; Papich, Mark; Lewbart, Gregory A; Christian, Shane; Gunkel, Conny; Harms, Craig A

    2006-12-01

    The nonsteroidal antiinflammatory drug ketoprofen (KTP) is a commonly used antiinflammatory and analgesic agent in reptile medicine, but no studies documenting its pharmacokinetics in this species have been published. Ketoprofen was administered as a racemic mixture to green iguanas (Iguana iguana) intravenously (i.v.) and intramuscularly (i.m.) at 2 mg/kg. Pharmacokinetic analyses were performed and indicated that ketoprofen in iguanas administered by the intravenous route has a classical two-compartmental distribution pattern, a slow clearance (67 ml/ kg/hr) and a long terminal half-life (31 hr) compared to ketoprofen studies reported in mammals. When delivered by the intramuscular route, bioavailability was 78%. These data indicate the daily dosing that is generally recommended for reptile patients, as an extrapolation from mammalian data, may be more frequent than necessary.

  15. Influence of conjugated linoleic acid (CLA on intramuscular fatty acid composition in rabbit

    Directory of Open Access Journals (Sweden)

    C. Corino

    2010-01-01

    Full Text Available The impact of feeding CLA has been thoroughly investigated in pigs, and Thiel- Cooper et al. (2001, Ostrowska et al. (2003, Lo Fiego et al. (2004, found that CLA modifies lipid fatty acid profile, negatively affecting some nutritional lipid indexes. So far,much less attention has been paid to rabbits. Recently, Corino et al. (2003 have shown that supplementing rabbit diets with CLA has limited effect on the chemical composition of meat and at a high slaughter weight reduces intramuscular fat content. The present research has been carried out to evaluate the effect of dietary CLA supplementation on cis-9, trans-11 and trans-10,cis-12- C18:2 isomers content, and on fatty acid composition of rabbit intramuscular lipids.

  16. Efficacy and safety of vitamin D3 B.O.N intramuscular injection in Korean adults with vitamin D deficiency

    Directory of Open Access Journals (Sweden)

    Han Seok Choi

    2016-12-01

    Conclusion: Intramuscular injection of vitamin D3 200,000 IU was superior to placebo in terms of its impact on serum 25(OHD concentrations, and is considered to be safe and effective in Korean adults with vitamin D deficiency.

  17. Pharmacokinetics of diclofenac in pigs after intramuscular administration of a single dose

    OpenAIRE

    Pejčić Zorica; Pokrajac Milena; Jezdimirović Milanka

    2006-01-01

    The pharmacokinetics of diclofenac was studied in 10 clinically normal male Yorkshire pigs, following intramuscular (i.m) administration of a single dose of diclofenac-sodium (2.5 mg/kg body weight). Diclofenac serum concentrations were determined by high pressure- liquid-chromatography (HPLC), with UV detection (226 nm). Following i.m. administration all individual diclofenac serum levels best fitted the one-compartment open model for extravascular administration. The maximal diclofenac seru...

  18. Acute selenium toxicity in lambs following intramuscular injection of sodium selenite

    Energy Technology Data Exchange (ETDEWEB)

    Caravaggi, C.; Clark, F.L.; Jackson, A.R.B.

    1970-01-01

    The LD50 in lambs from a farm where selenium deficiency has not been recorded was found to be 45..mu..g. of Se/kg. body weight when sodium selenite was administered as a single intramuscular injection. Marked pulmonary congestion and oedema were constantly present with degenerative changes in liver and kidney. A similarity was noted between the autopsy findings of acute selenosis and those described for enterotoxaemia. 13 references, 4 figures.

  19. Cefodizime in serum and skin blister fluid after single intravenous and intramuscular doses in healthy volunteers.

    OpenAIRE

    Korting, H C; Schäfer-Korting, M; Maass, L; Klesel, N; Mutschler, E

    1987-01-01

    In gonorrhea therapy, cephalosporins are conventionally administered by intramuscular (i.m.) injection, which rather frequently leads to local side effects. To investigate whether the well-tolerated intravenous (i.v.) injection of cephalosporins may be of comparable gonocidal effect, levels of cefodizime, a new broad-spectrum cephalosporin, in serum and tissue fluid (suction blister and cantharides blister fluid) were determined in six healthy men. Single doses of 1 g of cefodizime were injec...

  20. Vaccine-induced myositis with intramuscular sterile abscess formation: MRI and ultrasound findings

    Energy Technology Data Exchange (ETDEWEB)

    Polat, Ahmet Veysel; Bekci, Tumay; Selcuk, Mustafa Bekir [Ondokuz Mayis University, Department of Radiology, Faculty of Medicine, Samsun (Turkey); Dabak, Nevzat [Ondokuz Mayis University, Department of Orthopaedics and Traumatology, Faculty of Medicine, Samsun (Turkey); Ulu, Esra Meltem Kayahan [Samsun Medical Park Hospital, Department of Radiology, Samsun (Turkey)

    2015-12-15

    Although limb swelling is a well-known complication of vaccination, its rarity and wide band of differential diagnosis of limb swelling make it a diagnostic challenge. In this case report, we describe three cases of vaccine-induced myositis with intramuscular sterile abscess formation in patients with limb swelling and their magnetic resonance imaging and ultrasonography findings. Both radiologists and clinicians should be familiar with this rare entity, its clinical and imaging spectrum, and follow-up strategies. (orig.)

  1. Accessing the biocompatibility of layered double hydroxide by intramuscular implantation: histological and microcirculation evaluation

    OpenAIRE

    Cunha, Vanessa Roberta Rodrigues; de Souza, Rodrigo Barbosa; da Fonseca Martins, Ana Maria Cristina Rebello Pinto; Koh, Ivan Hong Jun; Constantino, Vera Regina Leopoldo

    2016-01-01

    Biocompatibility of layered double hydroxides (LDHs), also known as hydrotalcite-like materials or double metal hydroxides, was investigated by in vivo assays via intramuscular tablets implantation in rat abdominal wall. The tablets were composed by chloride ions intercalated into LDH of magnesium/aluminum (Mg2Al-Cl) and zinc/aluminum (Zn2Al-Cl). The antigenicity and tissue integration capacity of LDHs were assessed histologically after 7 and 28 days post-implantation. No fibrous capsule near...

  2. Serial MR Imaging of Intramuscular Hematoma: Experimental Study in a Rat Model with the Pathologic Correlation

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Yeon Soo; Kim, Jong Ok; Choi, Eun Seok [Daejeon St. Mary' s Hospital, The Catholic University of Korea, Daejeon (Korea, Republic of); Kwon, Soon Tae [Chungnam National University, School of Medicine, Daejeon (Korea, Republic of)

    2011-02-15

    We wanted to demonstrate the temporal changes of the magnetic resonance imaging (MRI) findings in experimentally-induced intramuscular hematomas in rats and to correlate these data with the concurrent pathologic observations. Intramuscular hematoma was induced in 30 rats. The MR images were obtained at 1, 4, 7 and 10 days and at 2, 3, 4, 6 and 8 weeks after muscle injury. The characteristic serial MRI findings were evaluated and the relative signal intensities were calculated. Pathologic specimens were obtained at each time point. On the T1-weighted imaging (T1WI), the intramuscular hematomas exhibited isointensity compared to that of muscle or the development of a high signal intensity (SI) rim on day one after injury. The high SI persisted until eight weeks after injury. On the T2-weighted imaging (T2WI), the hematomas showed high SI or centrally low SI on day one after injury, and mainly high SI after four days. A dark signal rim was apparent after seven days, which was indicative of hemosiderin on the pathology. The gradient echo (GRE) imaging yielded dark signal intensities at all stages. Unlike brain hematomas, experimentally-induced intramuscular hematomas show increased SI on both the T1WI and T2WI from the acute stage onward, and this is pathologically correlated with a rich blood supply and rapid healing response to injury in the muscle. On the T2WI and GRE imaging, high SI with a peripheral dark signal rim is apparent from seven days to the chronic stage

  3. Concurrent emphysematous pyelonephritis and thigh necrotizing fasciitis after intramuscular administration of diclofenac

    Directory of Open Access Journals (Sweden)

    Fateme Shamekhi Amiri

    2014-01-01

    Full Text Available Necrotizing fasciitis (NF is a rapidly progressive, life-threatening soft tissue infec-tion. NF may result from any injury to the skin or from hematogenous spread. However, con-current emphysematous pyelonephritis and necrotizing fasciitis of the left thigh has not been reported. We report a case of emphysematous pyelonephritis and necrotizing fasciitis of the left thigh after intramuscular administration of diclofenac that improved with aggressive management including broad-spectrum antibiotics, nephrectomy and surgical intervention.

  4. Serial MR Imaging of Intramuscular Hematoma: Experimental Study in a Rat Model with the Pathologic Correlation

    International Nuclear Information System (INIS)

    Lee, Yeon Soo; Kim, Jong Ok; Choi, Eun Seok; Kwon, Soon Tae

    2011-01-01

    We wanted to demonstrate the temporal changes of the magnetic resonance imaging (MRI) findings in experimentally-induced intramuscular hematomas in rats and to correlate these data with the concurrent pathologic observations. Intramuscular hematoma was induced in 30 rats. The MR images were obtained at 1, 4, 7 and 10 days and at 2, 3, 4, 6 and 8 weeks after muscle injury. The characteristic serial MRI findings were evaluated and the relative signal intensities were calculated. Pathologic specimens were obtained at each time point. On the T1-weighted imaging (T1WI), the intramuscular hematomas exhibited isointensity compared to that of muscle or the development of a high signal intensity (SI) rim on day one after injury. The high SI persisted until eight weeks after injury. On the T2-weighted imaging (T2WI), the hematomas showed high SI or centrally low SI on day one after injury, and mainly high SI after four days. A dark signal rim was apparent after seven days, which was indicative of hemosiderin on the pathology. The gradient echo (GRE) imaging yielded dark signal intensities at all stages. Unlike brain hematomas, experimentally-induced intramuscular hematomas show increased SI on both the T1WI and T2WI from the acute stage onward, and this is pathologically correlated with a rich blood supply and rapid healing response to injury in the muscle. On the T2WI and GRE imaging, high SI with a peripheral dark signal rim is apparent from seven days to the chronic stage

  5. Penetration of moxalactam and cefazolin into atrial appendage after simultaneous intramuscular or intravenous administration.

    OpenAIRE

    Polk, R E; Smith, J E; Ducey, K; Lower, R R

    1982-01-01

    This study compared the penetration of moxalactam and cefazolin into the human atrial appendage after simultaneous administration of both drugs by two routes. Nineteen adult patients scheduled for coronary vein bypass surgery randomly received 10 mg of moxalactam and cefazolin per kg by either the intramuscular or intravenous (bolus) route on administration of anesthesia. Concentrations of cefazolin in serum were significantly greater than concentrations of moxalactam at all times for both ro...

  6. Efficacy and Tolerability of Intramuscular Dexketoprofen in Postoperative Pain Management following Hernia Repair Surgery

    Directory of Open Access Journals (Sweden)

    P. T. Jamdade

    2011-01-01

    Full Text Available Objective. To evaluate the safety and efficacy of intramuscular dexketoprofen for postoperative pain in patients undergoing hernia surgery. Methodology. Total 202 patients received single intramuscular injection of dexketoprofen 50 mg or diclofenac 50 mg postoperatively. The pain intensity (PI was self-evaluated by patients on VAS at baseline 1, 2, 4, 6, and 8 hours. The efficacy parameters were number of responders, difference in PI (PID at 8 hours, sum of analogue of pain intensity differences (SAPID, and onset and duration of analgesia. Tolerability assessment was done by global evaluation and adverse events in each group. Results. Dexketoprofen showed superior efficacy in terms of number of responders (P=.007, PID at 8 hours (P=.02, and SAPID 0–8 hours (P<.0001. It also showed faster onset of action (42 minutes and longer duration of action (6.5 hours. The adverse events were comparable in both groups. Conclusion. Single dose of dexketoprofen trometamol 50 mg given intramuscularly provided faster, better, and longer duration of analgesia in postoperative patients of hernia repair surgery than diclofenac 50 mg, with comparable safety.

  7. Intramuscular Electrical Stimulation for Muscle Activation of the Tibialis Anterior After Surgical Repair: A Case Report.

    Science.gov (United States)

    Hollis, Sharon; McClure, Philip

    2017-12-01

    Background Loss of voluntary activation of musculature can result in muscle weakness. External neuromuscular stimulation can be utilized to improve voluntary activation but is often poorly tolerated because of pain associated with required stimulus level. Intramuscular electrical stimulation requires much lower voltage and may be better tolerated, and therefore more effective at restoring voluntary muscle activation. Case Description A 71-year-old man sustained a rupture of the distal attachment of the tibialis anterior tendon. Thirty-two weeks after surgical repair, there was no palpable or visible tension development in the muscle belly or tendon. Dorsiflexion was dependent on toe extensors. Electrical stimulation applied via a dry needling placement in the muscle belly was utilized to induce an isometric contraction. Outcomes Five sessions of intramuscular electrical stimulation were delivered. By day 4 (second visit), the patient was able to dorsiflex without prominent use of the extensor hallucis longus. By day 6 (third visit), active-range-of-motion dorsiflexion with toes flexed increased 20° (-10° to 10°). Eighteen days after the initial treatment, the patient walked without his previous high-step gait pattern, and the tibialis anterior muscle test improved to withstanding moderate resistance (manual muscle test score, 4/5). Discussion The rapid change in muscle function observed suggests that intramuscular electrical stimulation may facilitate voluntary muscle activation. Level of Evidence Therapy, level 5. J Orthop Sports Phys Ther 2017;47(12):965-969. Epub 15 Oct 2017. doi:10.2519/jospt.2017.7368.

  8. Comparison of surface and intramuscular EMG pattern recognition for simultaneous wrist/hand motion classification.

    Science.gov (United States)

    Smith, Lauren H; Hargrove, Levi J

    2013-01-01

    The simultaneous control of multiple degrees of freedom (DOFs) is important for the intuitive, life-like control of artificial limbs. The objective of this study was to determine whether the use of intramuscular electromyogram (EMG) improved pattern classification of simultaneous wrist/hand movements compared to surface EMG. Two pattern classification methods were used in this analysis, and were trained to predict 1-DOF and 2-DOF movements involving wrist rotation, wrist flexion/extension, and hand open/close. The classification methods used were (1) a single pattern classifier discriminating between 1-DOF and 2-DOF motion classes, and (2) a parallel set of three classifiers to predict the activity of each of the 3 DOFs. We demonstrate that in this combined wrist/hand classification task, the use of intramuscular EMG significantly decreases classification error compared to surface EMG for the parallel configuration (p<0.01), but not for the single classifier. We also show that the use of intramuscular EMG mitigates the increase in errors produced when the parallel classifier method is trained without 2-DOF motion class data.

  9. Quadriceps and hamstring muscle activity during cycling as measured with intramuscular electromyography.

    Science.gov (United States)

    da Silva, Julio Cézar Lima; Tarassova, O; Ekblom, M M; Andersson, E; Rönquist, G; Arndt, A

    2016-09-01

    The aim of this study was to describe thigh muscle activation during cycling using intramuscular electromyographic recordings of eight thigh muscles, including the biceps femoris short head (BFS) and the vastus intermedius (Vint). Nine experienced cyclists performed an incremental test (start at 170 W and increased by 20 W every 2 min) on a bicycle ergometer either for a maximum of 20 min or to fatigue. Intramuscular electromyography (EMG) of eight muscles and kinematic data of the right lower limb were recorded during the last 20 s in the second workload (190 W). EMG data were normalized to the peak activity occurring during this workload. Statistical significance was assumed at p ≤ 0.05. The vastii showed a greater activation during the 1st quadrant compared to other quadrants. The rectus femoris (RF) showed a similar activation, but with two bursts in the 1st and 4th quadrants in three subjects. This behavior may be explained by the bi-articular function during the cycling movement. Both the BFS and Vint were activated longer than, but in synergy with their respective agonistic superficial muscles. Intramuscular EMG was used to verify muscle activation during cycling. The activation pattern of deep muscles (Vint and BFS) could, therefore, be described and compared to that of the more superficial muscles. The complex coordination of quadriceps and hamstring muscles during cycling was described in detail.

  10. Leg amputation following intramuscular injection of iron dextran in a 32 year old woman

    Directory of Open Access Journals (Sweden)

    Gloria Shalviri

    2015-10-01

    Full Text Available To inform healthcare professionals of a rare serious reaction leading to leg amputation following intramuscular injection of iron dextran and report comments for preventing such reactions.A case of leg amputation following intramuscular injection of iron dextran reported to Iranian Pharmacovigilance Center was reviewed. Patient and reaction data was collected by assessing the reported yellow card, patient chart review and interviewing with patient and physicians. World Health Organization definition for serious reactions was used to determine the seriousness of the reaction. Naranjo algorithm was used to determine probability scale. The probability of the reaction was determined based on questionnaire of Schumock et al. The studied case is classified as a rare and serious but preventable reaction induced by intramuscular injection of iron dextran in a 32 year old woman. The probability of the reaction is appeared to be “probable” based on Naranjo algorithm. It seems that Iron dextran could cause serious and life threatening adverse effects. It is necessary for healthcare professionals to be informed of such rare but serious reaction in order to apply preventive actions.

  11. Irreversible muscle damage in bodybuilding due to long-term intramuscular oil injection.

    Science.gov (United States)

    Banke, I J; Prodinger, P M; Waldt, S; Weirich, G; Holzapfel, B M; Gradinger, R; Rechl, H

    2012-10-01

    Intramuscular oil injections generating slowly degrading oil-based depots represent a controversial subject in bodybuilding and fitness. However they seem to be commonly reported in a large number of non-medical reports, movies and application protocols for 'site-injections'. Surprisingly the impact of long-term (ab)use on the musculature as well as potential side-effects compromising health and sports ability are lacking in the medical literature. We present the case of a 40 year old male semi-professional bodybuilder with systemic infection and painful reddened swellings of the right upper arm forcing him to discontinue weightlifting. Over the last 8 years he daily self-injected sterilized sesame seed oil at numerous intramuscular locations for the purpose of massive muscle building. Whole body MRI showed more than 100 intramuscular rather than subcutaneous oil cysts and loss of normal muscle anatomy. 2-step septic surgery of the right upper arm revealed pus-filled cystic scar tissue with the near-complete absence of normal muscle. MRI 1 year later revealed the absence of relevant muscle regeneration. Persistent pain and inability to perform normal weight training were evident for at least 3 years post-surgery. This alarming finding indicating irreversible muscle mutilation may hopefully discourage people interested in bodybuilding and fitness from oil-injections. The impact of such chronic tissue stress on other diseases like malignancy remains to be determined. © Georg Thieme Verlag KG Stuttgart · New York.

  12. Sodium Nitrite and Sodium Thiosulfate Are Effective Against Acute Cyanide Poisoning When Administered by Intramuscular Injection.

    Science.gov (United States)

    Bebarta, Vikhyat S; Brittain, Matthew; Chan, Adriano; Garrett, Norma; Yoon, David; Burney, Tanya; Mukai, David; Babin, Michael; Pilz, Renate B; Mahon, Sari B; Brenner, Matthew; Boss, Gerry R

    2017-06-01

    The 2 antidotes for acute cyanide poisoning in the United States must be administered by intravenous injection. In the out-of-hospital setting, intravenous injection is not practical, particularly for mass casualties, and intramuscular injection would be preferred. The purpose of this study is to determine whether sodium nitrite and sodium thiosulfate are effective cyanide antidotes when administered by intramuscular injection. We used a randomized, nonblinded, parallel-group study design in 3 mammalian models: cyanide gas inhalation in mice, with treatment postexposure; intravenous sodium cyanide infusion in rabbits, with severe hypotension as the trigger for treatment; and intravenous potassium cyanide infusion in pigs, with apnea as the trigger for treatment. The drugs were administered by intramuscular injection, and all 3 models were lethal in the absence of therapy. We found that sodium nitrite and sodium thiosulfate individually rescued 100% of the mice, and that the combination of the 2 drugs rescued 73% of the rabbits and 80% of the pigs. In all 3 species, survival in treated animals was significantly better than in control animals (log rank test, Pcyanide poisoning in 3 clinically relevant animal models of out-of-hospital emergency care. Copyright © 2016 American College of Emergency Physicians. Published by Elsevier Inc. All rights reserved.

  13. Raising perforator flaps for breast reconstruction: the intramuscular anatomy of the deep inferior epigastric artery.

    Science.gov (United States)

    Rozen, Warren M; Ashton, Mark W; Pan, Wei R; Taylor, G Ian

    2007-11-01

    The deep inferior epigastric artery (DIEA) perforator flap is used increasingly for breast reconstruction, preferred as a muscle-sparing operation over traditional transverse rectus abdominis musculocutaneous (TRAM) flaps. Complications related to the inclusion of rectus abdominis include abdominal wall weakness and a predisposition to ventral abdominal wall hernias. DIEA perforator flaps still present this complication, with clinical experience demonstrating frequent transection of rectus fibers during dissection of perforators. Despite this, published descriptions of the DIEA in the literature describe a "direct" course through rectus abdominis. This study interprets these clinical findings by analyzing the intramuscular course of the perforators. The investigation was performed on 31 hemiabdominal walls from both fresh and embalmed cadavers, using a combination of dissection and radiography of multiple cross-sectional planes. Intramuscular distances were measured using the distances between entry and exit points of perforators from rectus abdominis muscle, allowing characterization of the intramuscular course. Substantial longitudinal (mean, 1.52 cm; range, 0.2 to 4.1 cm) and transverse (mean, 1.32 cm; range, 0.3 to 3.5 cm) distances were traversed by each of the 76 perforators within the muscle. A significant transverse distance was shown to be traversed by perforators, confirming the need for division of rectus abdominis fibers during operation. This information may help explain the clinical findings of abdominal wall morbidity following perforator flaps, and may pave the way for improved preoperative selection of patients for DIEA perforator flaps.

  14. Intramuscular versus intravenous prophylactic oxytocin for postpartum hemorrhage after vaginal delivery: a randomized controlled study.

    Science.gov (United States)

    Dagdeviren, Hediye; Cengiz, Huseyin; Heydarova, Ulkar; Caypinar, Sema Suzen; Kanawati, Ammar; Guven, Ender; Ekin, Murat

    2016-11-01

    Prevention of postpartum haemorrhage (PPH) is essential in the pursuit of improved health care for women. Oxytocin, the most commonly used uterotonic agent to prevent PPH, has no established the route of administration. In this study we aimed to compare whether the mode of oxytocin administration, i.e., intravenous and intramuscular administration, has an effect on the potential benefits and side effects. A total of 256 women were randomised into two groups: intramuscular group (128) or intravenous group (128). Estimated blood loss during the third stage of labour was similar between the two groups (p = 0.572). Further there were no statistically significant difference was noted between the two groups in terms of the mean duration of labor, duration of the third stage of labor, manual removal of the placenta, need for instrumental delivery, need for blood transfusion, PPH ≥500 mL, PPH ≥1000 mL, or length of hospital stay. Using oxytocin by intravenous and intramuscular route has a similar efficacy and adverse effects.

  15. Safety, Pharmacokinetics, and Immunogenicity of Obiltoxaximab After Intramuscular Administration to Healthy Humans.

    Science.gov (United States)

    Nagy, Christa F; Leach, Timothy S; King, Alex; Guttendorf, Robert

    2017-11-10

    Inhalational anthrax is a highly lethal infection caused by Bacillus anthracis and a serious bioterrorism threat. Protective antigen (PA) is a critical component required for the virulence of Bacillus anthracis. Obiltoxaximab, a high-affinity monoclonal antibody that neutralizes PA, is approved in the United States for intravenous use for the treatment of inhalational anthrax in combination with appropriate antibacterial drugs and for prophylaxis of inhalational anthrax when alternative therapies are not available or appropriate. Here, we explored the safety, pharmacokinetics (PK), and immunogenicity of obiltoxaximab administered by intramuscular injection at doses of 4, 8, 16, 20, and 24 mg/kg in healthy humans. Systemic exposures were approximately dose proportional, maximum serum concentrations were observed after 6-9 days, and terminal half-life ranged from 16 to 23 days. Average absolute intramuscular bioavailability was 64%. Obiltoxaximab was well tolerated, and local tolerability was acceptable up to 24 mg/kg intramuscularly, up to 6 injections per dose, and up to 5 mL per injection. No injection-site abscesses or hypersensitivity reactions occurred; no subjects developed treatment-emergent antitherapeutic antibodies over the study period of 71 days. © 2017, The American College of Clinical Pharmacology.

  16. The myotoxicity of organic cosolvents following intramuscular injection: Characterization and mechanistic studies

    International Nuclear Information System (INIS)

    Brazeau, G.A.

    1989-01-01

    An in vitro rat muscle model for myotoxicity estimation was first developed. This system, which utilizes creatine kinase release as an index of myotoxicity, allows the myotoxicity of intramuscular solutions to be rapidly screened, without the limitations associated with published methods. This in vitro myotoxicity screening technique was validated against in vivo myotoxicity data in rabbits. The concentration-myotoxicity relationships were determined for the aqueous solutions of each of the cosolvents. The myotoxicity of mixed solvents consisting of propylene glycol, ethanol, and water was shown to be additive. This relationship of linear combination did not apply to ternary mixtures containing polyethylene glycol 400, which appeared to exert a protective effect in these mixtures. The possible mechanisms of organic cosolvent-induced myotoxicity were investigated. Myotoxicity was shown not to be linearly correlated with simple physicochemical properties nor with linear combinations of these properties. Results from biochemical studies suggested that organic cosolvent-induced creatine kinase release was caused by alterations in intracellular calcium homeostasis and not by direct solubilization of the sarcolemma. A final study explored the effect of muscle damage on the intramuscular bioavailability of a model compound dissolved in three cosolvent solutions with similar physicochemical properties but with different myotoxicities. Relative-bioavailability of a 14 C-diazepam tracer dose was not different among these solutions, while the in vivo myotoxicity of the solutions varied ten fold. These initial findings suggest that intramuscular drug bioavailability does not appear to be affected by skeletal muscle damage

  17. Um mundo de cores

    Directory of Open Access Journals (Sweden)

    Elis Artz

    2016-08-01

    Full Text Available A pintura de Elis Artz é feita com muita alma e transborda alegria. A vitalidade de seu trabalho transparece nas cores fortes e nos traços simples e harmoniosos. Confira o trabalho da artista nesta edição da Revista Jangada. ELIS by ELIS Descobri meu talento artístisco e criativo há uns 25 anos. Nasci no Brasil e me mudei para os EUA 10 anos atrás por puro amor. Embora seja psicóloga de formação, o meu apreço pela pintura só cresceu e, com o passar dos anos, a paixão pelas tintas me direcionou a fazer cursos com artistas brasileiros renomados. Já morando nos EUA e com essa grande paixão adormecida, durante anos, decidi me entregar para as cores que sempre me trouxeram alegria e cor para os meus dias. Embora muitas de minhas pinturas tenham ido para minha família e amigos no Brasil, vendi inúmeras outras pelo país através de exposições em galerias de arte. Em 2014, fui uma das artistas em destaque no MTD ART nos Estados Unidos. Minha obra estava dentro de cada ônibus das cidades de Champaign e Urbana e exposta em destaque na Estação de Trem. Em maio de 2015, tive o prazer de ter outro trabalho meu nos outdoors da cidade, destacando a minha tela 'Frida' o ano inteiro e de expor em conjunto com alguns artistas locais no final de outubro. Desde então, tenho pintado cada vez mais e me interessado em divulgar o meu trabalho. E, como diria um amigo meu "Elis, você me mostrou que a vida não é só preto no branco". Ele estava certo.

  18. Effect of weight, sex and hunting period on fatty acid composition of intramuscular and subcutaneous fat from wild boar

    Directory of Open Access Journals (Sweden)

    Artūras Šiukščius

    2012-04-01

    Full Text Available The study examined the influence of weight, sex and month of hunting on the fatty acid composition of intramuscular and subcutaneous fat from 49 free ranging wild boars hunted in Lithuania during the winter season. A total number of 27 and 25 fatty acids were identified in the intramuscular fat and subcutaneous tissue of wild boars, respectively. The weight of the wild boar had mainly affected only the levels of separate fatty acids both in the intramuscular and subcutaneous fat. Higher levels of saturated fatty acids (SFA were found in the intramuscular and subcutaneous fat of males compared with females. The effect of both weight and sex on the levels of fatty acids was higher in the subcutaneous fat than in the intramuscular fat. Weight, sex and hunting month had no effect on PUFA/SFA and n-6 PUFA/n-3 PUFA ratios in the intramuscular and subcutaneous fat. The atherogenic (AI and thrombogenic (TI indexes and hypocholesterolemic/hypercholesterolemic ratio in subcutaneous fat were more favorable in females compared with males and in the January hunting season than in November and December.

  19. Caracterização funcional de genes importantes no metabolismo de xilose das leveduras Rhodotorula dairenensis e Pseudozyma brasiliensis sp. nov

    OpenAIRE

    Thuanny Andrade Borges

    2014-01-01

    Resumo: A completa utilização da biomassa lignocelulósica é um dos pré-requisitos para tornar o processo do etanol de segunda geração economicamente competitivo. Entretanto, a fermentação dos açúcares disponíveis na biomassa celulósica apresenta um desafio único em decorrência da presença de outros açúcares, além da glicose, tais como xilose e arabinose, os quais não são fermentáveis por Saccharomyces cerevisiae, a principal levedura utilizada na indústria. Em leveduras, a conversão de D-xilo...

  20. El problema judío en la mente de tres importantes personajes del siglo VII : un papa, un obispo español y un rey visigodo

    Directory of Open Access Journals (Sweden)

    Ángel Riesco Terrero

    1993-01-01

    Full Text Available El «antisemitismo» y más concretamente el «antijudaísmo», aparte de fenómeno complejo, es tan antiguo y nuevo como el propio pueblo de Israel. Pero tal vez sea más importante caer en la cuenta de que esa animadversión, a veces, odio, indiferencia, antipatía, persecución... ha actuado como eficaz revulsivo, convirtiéndose para muchos en afecto, simpatía y admiración o, por lo menos, en una de las causas principales y de mayor interés por la historia del pueblo judío.

  1. Dinámica de la molécula más importante de la vida: el ADN. I. Modelos lineales y no lineales

    Directory of Open Access Journals (Sweden)

    Lorena Ramírez Reyes

    2005-01-01

    Full Text Available En este artículo se revisan los modelos más simples para la molécula más importante dela vida: el ADN. Se estudian las excitaciones colectivas y paulatinamente van incorporándose en elanálisis cualidades complejas de la molécula. Esto conlleva al estudio de la dinámica de talesexcitaciones mediante ecuaciones diferenciales no lineales. Las soluciones especiales de estasecuaciones corresponden a un tipo de ondas no lineales que mantienen forma y velocidadconstantes con la mínima pérdida de energía e información, conocidas como solitones ocompactones.

  2. Caso clínico radiológico fecaloma : importante complicación en adultos mayores con constipación crónica

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    Dr. S. Andrés O´Brien

    2012-01-01

    Full Text Available La constipación crónica es un síntoma de alta frecuencia en la población, siendo uno de los principales motivos de consulta gastroenterológica. Su prevalencia puede ser muy alta en adultos mayores, en especial a nivel de asilos, donde alcanza un 80%. Una de las complicaciones más importante es la Impactación Fecal o Fecaloma, que puede determinar la formación de úlceras estercoráceas y eventualmente perforación, con una alta morbimortalidad. Se presenta un caso de un gran fecaloma en paciente de 80 años que consulta por masa palpable hipogástrica.

  3. Hemofilia adquirida: relato de um caso

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    Marcelo Gil Cliquet

    2015-10-01

    Full Text Available Hemofilia A Adquirida (HAA é uma desordem hemorrágica incomum causada pelo desenvolvimento de autoanticorpos policlonais da subclasse IgG 4 contra o FVIII. O tratamento usual envolve a administração de FVIII humano ou recombinante parcialmente ativado eventualmente associados a imunossupressores. Relato do caso: Paciente, 86 anos, masculino, chegou ao PS com equimoses e hematomas pelo corpo. Evoluiu com obstrução da cavidade oral e entrou em insuficiência respiratória. Foi necessária traqueostomia. Exames laboratoriais: hemograma normal com leve queda da hemoglobina. Tempo de Protrombina Normal e TTPa > 100 seg. Solicitada a dosagem de Fator VIII e de inibidor se apresentando a 2% e presença de anticorpo anti-Fator VIII. O paciente recebeu Plasma Fresco Congelado e Crioprecipitado nos primeiros dias sem melhora e, após a chegada da dosagem do Fator e inibidor, foi iniciada imunossupressão com Solumedrol 1g EV por 3 dias seguido de Prednisona 1 a 2 mg/Kg. Dias depois iniciada Azathioprina, 50mg/dia e depois 100 mg/dia, além de FEIBA de acordo com a ocorrência de sangramentos. Evoluiu com melena, enterorragia e queda importante da hemoglobina, necessitando de transfusões. Após cerca de 30 dias do início da imunossupressão, foi observado resolução do quadro hemorrágico, redução do TTPa para cerca de 50 segundos e elevação do nível do FVIII para 8%. Conclusão: A imunossupressão foi essencial e conseguiu diminuir o título dos anticorpos e elevou os níveis de Fator VIII, resolvendo o quadro hemorrágico, mas isso só ocorreu após um mês de seu início. O suporte com fatores ativados foi crucial neste caso até que a imunossupressão fizesse efeito. Temia-se por eventos tromboembólicos que ocorreram tardiamente e, por isso, acreditamos ser um evento não relacionado a ele

  4. Centro histórico como território turístico criativo: um estudo em um destino turístico internacional no Brasil

    Directory of Open Access Journals (Sweden)

    Magnus Luiz Emmendoerfer

    2016-08-01

    Full Text Available O objetivo é analisar os elementos que possibilitam qualificar um centro histórico como um Território Turístico Criativo (TTC. Para realizar esta investigação, a cidade de Ouro Preto, Minas Gerais, Brasil, foi escolhida por ser um destino turístico internacional e por ser reconhecida mundialmente pela Organização das Nações Unidas para a Educação, a Ciência e a Cultura - UNESCO como patrimônio cultural. Em termos metodológicos, esta análise foi realizada com base em dados documentais e bibliográficos. Como resultados, foram apresentadas características para qualificar um centro histórico como um território turístico e criativo. Também observou-se níveis distintos de territórios criativos no contexto do turismo que podem (coexistirem na cidade investigada. Ao mesmo tempo, observou-se limitadas conexões justamente onde há expressões de criatividade e cultura. Portanto, esta investigação demonstrou que o processo de qualificação de territórios turísticos criativos é algo importante na contemporaneidade para a gestão do turismo e de destinos de forma sustentável.

  5. Levantamento das condições de trabalho em um serviço de equoterapia segundo a visão macroergonômica

    OpenAIRE

    Luís Cláudio Martins Chiaramonte

    2004-01-01

    Este estudo tem como objetivo investigar as condições de trabalho de um serviço de equoterapia. A metodologia utilizada foi a ferramenta Design Macroergonômico (DM) proposto por Fogliatto e Guimarães (1999), tendo sido avaliadas as demandas ergonômicas dos dez trabalhadores de um Centro de Equoterapia da Cidade de Caxias do Sul. Os resultados indicam que as exigências físicas do trabalho não são um problema e que os trabalhadores não sentem dor como era esperado. As demandas importantes dizem...

  6. Inscrever (no espaço, mapear e historicizar fronteiras: uma análise sobre a “Carta Cartographica dos pontos importantes do território em litígio na questão de limites entre o Estado do Rio Grande do Norte e o Estado do Ceará” (1903

    Directory of Open Access Journals (Sweden)

    Saul Estevam Fernandes

    2011-01-01

    Full Text Available In this article I try to analyze the “Carta Topographica dos pontos importantes do território em litígio na questão de limites entre o Estado do Rio Grande do Norte e o Estado do Ceará”, produced in 1903 by the engineer, astrologer, teacher and cartographer Manuel Pereira Reis. I try to explain, at first, how the family Albuquerque Maranhão was associated with a network of relationships that constituted and was formed by the insertion of respected intellectuals of the time, as Tavares de Lyra, Rui Barbosa and Manuel Pereira Reis. In a second time, I try to understand how the cartographic production is used as a device in the Rio Grande do Norte’s registration, mapping and historicity. / Neste artigo tento analisar a “Carta Topographica dos pontos importantes do território em litígio na questão de limites entre o Estado do Rio Grande do Norte e o Estado do Ceará”, produzido no ano de 1903, pelo engenheiro, astrônomo, professor, cartógrafo e deputado federal pelo Rio Grande do Norte Manuel Pereira Reis. Tento explicitar, em um primeiro momento, de que maneira a família Albuquerque Maranhão esteve associada à uma rede de relações que constituiu e foi constituída pela inserção de respeitados intelectuais da época, como Tavares de Lyra, Rui Barbosa e Manuel Pereira Reis. Em um segundo momento, busco entender de que maneira a produção cartográfica é utilizada como artifício na inscrição, mapeamento e historicização do espaço potiguar.

  7. Um modelo para analisar o problema de filas em caixas de supermercados: um estudo de caso

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    Reinaldo Morabito

    2000-06-01

    Full Text Available Neste estudo aplicamos teoria de filas para analisar o problema de congestão em caixas de supermercados. Estamos particularmente interessados em modelar o tempo médio de espera em fila, aqui entendido como uma componente importante do nível de serviço ao consumidor, em função da capacidade do sistema (i.e., o número de caixas num dado período de tempo. Três modelos são explorados: (i representar o sistema por meio de um simples modelo M/M/m de fila única, onde m é o número de caixas, (ii representar o sistema por meio de m modelos M/M/1 paralelos e independentes, e (iii representar o sistema por meio de um modelo Markoviano mais geral, onde os dois modelos anteriores podem ser vistos como casos particulares. Para avaliar o desempenho destes modelos, realizamos um estudo de caso num dos supermercados da rede Jaú-Serve, localizado no interior de São Paulo. Os resultados mostraram que o terceiro modelo pode resultar numa boa aproximação para o problema, ao contrário dos dois primeiros.In this study we applied queueing theory to analyze the problem of congestion in supermarket check-outs. We are particularly concerned with modeling the mean user waiting time in the queue, viewed as an important component of the user service, as a function of the capacity of the system (i.e., the number of cashiers in a given time period. Three models are explored: (i to represent the system by means of a simple M/M/m queueing model, where m is the number of cashiers, (ii to represent the system by means of m parallel and independent M/M/1 queueing models, and (iii to represent the system by means of a more generic Markovian model, where the former models can be viewed as particular cases. In order to evaluate the performance of the models, we developed a case study in one of the supermarkets of Jaú-Serve chain located in São Paulo State. The results showed that the third model can yield a good approximation for the problem, different from the

  8. Reflexões teóricas sobre o ensino do Empreendedorismo: a tentativa de construção de um modelo baseado na integração das áreas do conhecimento

    OpenAIRE

    Mendes de Oliveira, Janaina

    2015-01-01

    Este estudo tem com como objetivo buscar referenciais para construir um modelo teórico que possa ser utilizado pelos agentes responsáveis pelo desenvolvimento regional. O empreendedorismo tem um importante papel para gerar a capacidade empreendedora de uma região e os agentes como instituições de ensino e/ou poder público deverão seguir determinadas orientações para a consecução deste objetivo. Construir uma teoria é um caminho difícil, pois não existe um conceito único. Alinhando as ciências...

  9. A psicologia histórico-cultural soviética (1917-1991): problemas de paternidade associados a obras e autores importantes

    OpenAIRE

    Roberto Valdés Puentes

    2017-01-01

    Resumo: Mukhina e Venguer estão envolvidos em problemas de “paternidade”. Chegou-se a conclusão que os livros Temas de psicologia pré-escolar e Psicologia Pré-escolar, publicados por Venguer e Mukhina, respectivamente, são praticamente um único livro devido a seu conteúdo. Em tal sentido, recomenda-se que os autores sejam adequadamente citados, com base na edição específica, acrescida, no segundo caso, da problematização que existe em torno dessas obras e autores, bem como de uma posição que ...

  10. Vivencias emocionais de mulheres submetidas a cirurgia bariatrica no Hospital de Clinicas da Unicamp : um estudo clinico-qualitativo

    OpenAIRE

    Ronis Magdaleno Junior

    2009-01-01

    Resumo: Este estudo teve por objetivo compreender as vivências emocionais de mulheres obesas mórbidas submetidas à cirurgia bariátrica. A obesidade tornou-se, globalmente, um grave problema de saúde pública e, em função disto, tem crescido de modo expressivo o número de cirurgias bariátricas como opção de tratamento para a obesidade mórbida. Contudo, é um procedimento que implica em importantes modificações físicas e psicossociais para o paciente. Metodologia: Aplicamos o Método Clínico Quali...

  11. Videocâmeras em biotérios de experimentação: importante ferramenta no controle da contaminação ambiental na microbiota de camundongos

    Directory of Open Access Journals (Sweden)

    C.A. Muller

    2015-06-01

    Full Text Available O objetivo do presente estudo foi verificar a influência da contaminação ambiental na microbiota dos animais utilizados em experimentação, usando-se videocâmera como ferramenta de controle, a partir da comparação de dois biotérios de experimentação, sendo um protegido com presença de videocâmeras (A e o outro não (B, quanto ao padrão microbiológico dos camundongos. Para os testes bacteriológicos, foram utilizadas amostras de 222 animais do biotério A e 236 do biotério B; para os testes virológicos, 119 do biotério A e 236 do biotério B; já para os exames parasitológicos, 158 do biotério A e 316 do biotério B. Os dados foram submetidos à análise descritiva e ao teste do Qui-quadrado. Verificou-se uma maior ocorrência de microrganismos e de parasitas no biotério não protegido pelas videocâmeras. Klebsiella pneumoniae, Pasteurella sp. e Pseudomonas sp. foram encontradas nos animais de ambos os biotérios, ao passo que vírus e parasitos só foram detectados nos animais no biotério não protegido. Dentre os vírus, nos animais infectados, o de maior ocorrência foi o Vírus da Hepatite de Camundongos (MHV e, dentre os parasitos, o de maior ocorrência foi Syphacia sp. Concluiu-se que o biotério protegido foi capaz de garantir padrões microbiológicos mais adequados para a experimentação animal, que as videocâmeras são importantes ferramentas de controle e que a prática da biossegurança deve ser constante nas instituições de pesquisa.

  12. Osteonecrose dos maxilares associada ao uso de bisfosfonatos: importante complicação do tratamento oncológico Bisphosphonate-associated jaws osteonecrosis: an important complication of oncology treatment

    Directory of Open Access Journals (Sweden)

    Marco Antonio T. Martins

    2009-02-01

    Full Text Available Os bisfosfonatos são um grupo de medicamentos utilizados no tratamento de doenças malignas metastáticas e em outras doenças ósseas como osteoporose e doença de Paget. A despeito dos seus benefícios, uma importante complicação denominada de osteonecrose dos maxilares vem sendo observada nos pacientes usuários crônicos dos bisfosfonatos que se caracteriza clinicamente por exposições ósseas na região maxilofacial persistente, acompanhadas de osteomielite, geralmente sintomáticas e cujo tratamento é complexo. Este estudo tem por objetivo revisar a literatura sobre a osteonecrose associada ao uso dos bisfosfonatos, em especial, em oncologia, no período de 2003 a 2008. Serão apresentados e discutidos os fatores de risco, aspectos etiopatogênicos, clínicos, imagenológicos, terapêuticos e preventivos desta doença. Devido à dificuldade de tratamento da osteonecrose associada aos bisfosfonatos, o foco deve ser a prevenção, sendo o ideal a eliminação de quadros infecciosos orais antes da terapia com os bisfosfonatos ter sido iniciada e minimizar traumas em boca após o uso destes medicamentos.Bisphosphonates are drugs used in the treatment of malignant metastatic diseases and in other bone lesions such as osteoporosis and Paget´s disease. Besides their benefits, jaw osteonecrosis, an important side effect, has been observed in long-term users of these drugs. Jaw osteonecrosis is clinically characterized by prolonged maxillary and mandible bone exposure accompanied by osteomyelitis. These lesions are usually symptomatic and difficult to treat. This study has the objective of reviewing publications from 2003 to 2008 about bisphosphonate-associated jaw osteonecrosis, in particular in relation to oncology. Risk factors, and etiopathological, clinical, radiographic, therapeutic, and preventive aspects of this condition are presented and discussed. Due to the difficulty to treat this disease, the focus must be prevention, with the

  13. Autoridade docente: repensar um conceito

    Directory of Open Access Journals (Sweden)

    Thiago Miranda dos Santos Moreira

    Full Text Available Resumo Vivemos uma crise de autoridade no mundo moderno e seu impacto no âmbito educacional tem sido objeto de análises e críticas sob diferentes perspectivas. De acordo com Hannah Arendt, esse não é um fenômeno gerado na esfera da educação, não obstante, seu impacto nesse âmbito apareça aos olhos da autora como o sintoma mais evidente da profundidade e seriedade desta crise. Este trabalho tem por objetivo analisar o conceito de autoridade na obra de Hannah Arendt, propondo uma abordagem que busca romper com as perspectivas que veem a autoridade como um epifenômeno do poder. Desse modo, busca-se lançar um olhar sobre a autoridade como um elemento consubstancial à educação e não como um mero instrumento de poder, submissão e sujeição de indivíduos. Assim, num primeiro momento, será apresentada a perspectiva de Alain Renaut, filósofo francês que, em sua abordagem da autoridade, dialoga direta e criticamente com Arendt. Em seguida, será apresentada a origem do conceito sob a perspectiva de Hannah Arendt, bem como sua relação com a educação.

  14. Recursos informacionais: importante aliado no processo de elaboração dos planos de aulas 10.5007/1518-2924.2007v12n23p92

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    Wilse Arena da Costa

    2007-11-01

    Full Text Available Sabendo da importância dos recursos informacionais no setor educacional, especialmente para elaboração do plano de aulas pelos professores das séries iniciais, realizou-se uma pesquisa na Escola Municipal Anfilófio de Souza Campos - EMASC, na cidade de Itiquira, Mato Grosso – MT. Procurou-se identificar os recursos informacionais utilizados pelos professores para enriquecer o conteúdo de suas disciplinas e dinamizar o processo ensino/aprendizagem. Enfatizou-se também, a partir de uma abordagem teórico-referencial, o papel do bibliotecário como agente nucleador da biblioteca como instituição viva e participante do conhecimento e das práticas pedagógicas desenvolvidas pelo professor. De forma peremptória, os resultados mostraram a prioridade dada ao livro didático e o uso reduzido ou inadequado da biblioteca, dos recursos eletrônicos e dos sites direcionados à Educação. Porém, um fator constatado que faz muita diferença em qualquer instituição escolar, nos dias atuais, é a ausência de um bibliotecário na EMASC.

  15. Intramuscular diclofenac vs periprostatic lidocaine injection for controlling pain undergoing transrectal ultrasound guided prostatic biopsy

    International Nuclear Information System (INIS)

    Alam, S.I.

    2017-01-01

    Background: Transrectal ultrasound (TRUS) technique for getting prostatic tissue for histopathology is now the standard procedure for malignant lesions of the prostate and imperative diagnostic investigation of patients with clinical specks of prostatic neoplasia. During TRUS guided biopsy, pain control has been important issue therefore, highly potent analgesia before this procedure should be considered on high priority according to current census. Therefore, we compared intramuscular diclofenac injection with sensory blockade of injection lidocaine to abolish pain undergoing prostatic biopsy with TRUS technique. Methods: Total 200 patients were selected for this study having raised PSA values and suspicious nodule on Digital Rectal Examination. These patients were segregated into two groups by randomization. Group Ar eceived intramuscular diclofenac and group Bw ere infiltrated with lidocaine injection for sensory blockade. Results: Patients in group A was having mean age of 64.5±5.8 years while for group B patients was 65.6±4.9 years (p=0.16). Both groups have statistically insignificant difference in their mean PSA values (p=0.24) and mean prostatic volume (p=0.22). The mean pain scores on visual analogue scale in groups A was 3.5±0.8 and in group B it was 2.4±0.8 (p<0.001). 60% group A patients reported with mild or no pain compared to 90% in group B. (p<0.001). Conclusion: Local blockade with lidocaine injection has better pain control as compared to patients experienced pain with intramuscular diclofenac used for prostatic biopsy through TRUS technique.

  16. Divergent selection on intramuscular fat in rabbits: Responses to selection and genetic parameters.

    Science.gov (United States)

    Martínez-Álvaro, M; Hernández, P; Blasco, A

    2016-12-01

    A divergent selection experiment on intramuscular fat (IMF) was performed in rabbits. The aim of this study is to estimate the response to selection, the correlated responses in carcass and meat quality traits, and their genetic parameters. Selection criterion was the averaged phenotypic value of IMF measured at 9 wk of age in 2 full-sibs of the candidate. Traits considered were IMF, BW, chilled carcass weight, reference carcass weight, scapular and perirenal fat weights, carcass and meat color, pH, protein and fatty acid composition of meat. Total direct response to selection for IMF was 2.6 phenotypic SD of the trait, around 5% of the mean (1.09 g/100 g) per generation, with both lines following a symmetrical trend. Heritability of IMF was high (0.54), and in general, all traits related to carcass fat depots and IMF fatty acid composition showed high heritabilities (dissectible fat of the carcass, 0.70; MUFA percentage, 0.61; PUFA percentage, 0.45; and PUFA:SFA ratio, 0.42), except SFA percentage (0.09). The other carcass and meat quality traits showed moderate to low heritabilities. Intramuscular fat and dissectible fat percentage showed a low genetic correlation (0.34). Intramuscular fat was positively correlated with MUFA percentage (0.95) and negatively correlated with PUFA percentage (-0.89) and PUFA:SFA ratio (-0.98), corroborated with high correlated responses to selection. The rest of the traits did not show any substantial correlated response except protein content, which was greater in the high-IMF line than in the low-IMF line.

  17. ¿Por qué es importante el género en la Pedagogía Crítica?

    Directory of Open Access Journals (Sweden)

    Consol Aguilar Ródenas

    2009-01-01

    Full Text Available El artículo muestra la necesidad de incluir desde la pedagogía crítica en el ámbito de la reforma educativa, no tan solo en la teoría, sino también en la práctica académica cotidiana, en la acción, el género como un elemento de transformación de las desigualdades sociales, mostrando algunos aspectos importantes de la relación entre conocimiento, poder y género que pueden ayudar a lograr esas transformaciones como, por ejemplo, el feminismo dialógico, la aportación de los feminismos a los estudios de las nuevas masculinidades o diversas investigaciones ligadas al análisis del curriculum educativo considerando la relación entre neoliberalismo, educación y género; la exclusión social; la relación entre género e interculturalidad y otro modelo de relación afectivo-sexual en la construcción de las identidades unido a la coeducación y el aprendizaje dialógico, recuperando el papel en política cultural y educativa del profesorado desde el compromiso.

  18. Diamorphine for pain relief in labour : a randomised controlled trial comparing intramuscular injection and patient-controlled analgesia.

    Science.gov (United States)

    McInnes, Rhona J; Hillan, Edith; Clark, Diana; Gilmour, Harper

    2004-10-01

    To compare the efficacy of diamorphine administered by a patient-controlled pump (patient-controlled analgesia) with intramuscular administration for pain relief in labour. Randomised controlled trial. The South Glasgow University Hospitals NHS Trust. Primigravidae and multigravidae in labour at term (37-42 weeks). Women were randomised in labour to the study (patient-controlled analgesia) or control group (intramuscular). Randomisation was achieved through a random permuted block design stratified by parity. Study group women were given a loading dose of 1.2 mg diamorphine intravenously and then attached to the pump. Control group women received intramuscular diamorphine as per hospital protocol. Participants were also given 3 mg of buccal Stemetil. Data were collected throughout labour and at six postnatal weeks. Analgesia requirements during labour and women's satisfaction with the method of pain relief. Women in the study group (patient-controlled analgesia) used significantly less diamorphine than women in the control group (intramuscular) but were significantly more likely to state that they were very dissatisfied with their use of diamorphine and were significantly more likely to opt out of the trial before the birth of the baby. The majority of women in both groups used other analgesia concurrent with diamorphine such as Entonox, aromatherapy or TENS. Patient-controlled analgesia administration of diamorphine for the relief of pain in labour offers no significant advantages over intramuscular administration. The results also suggest that diamorphine is a poor analgesic for labour pain irrespective of the mode of administration.

  19. Side effects and potential risk factors of botulinum toxin type A intramuscular injections in knee flexion contractures of hemophiliacs.

    Science.gov (United States)

    Rodriguez-Merchan, E Carlos; De la Corte-Rodriguez, Hortensia

    2017-07-01

    Knee flexion contracture (KFC) is a common complication of recurrent hemarthrosis in children and young adults with hemophilia. If the KFC is not prevented (by means of primary prophylaxis) and treated properly and early (be means of physical medicine and rehabilitation), it will become fixed. Areas covered: The aim of this article is to review the potential role of botulinum toxin type A (BTX-A) intramuscular injections for the treatment of KFC in people with hemophilia (PWH). Expert commentary: Although two recent reports have mentioned the benefits of intramuscular injections of BTX-A in PWH with KFC, the data are still scant and too preliminary. The use of intramuscular injections of BTX-A in PWH today should not be recommended until more case studies/small series (ideally well-designed clinical trials) fully demonstrate that this is safe and effective. The risks of intramuscular injections to a hemophilia patient cannot be underestimated (iatrogenic muscle hematomas and pseudotumors). This paper calls the attention of hemophilia treaters on the potential risks of this apparently interesting technique. The current use of BTX-A intramuscular injections in KFC of PWH could make no sense. Raising false expectations in these patients should be avoided.

  20. Contraction mode and whey protein intake affect the synthesis rate of intramuscular connective tissue

    DEFF Research Database (Denmark)

    Holm, Lars; Klejs Rahbek, Stine; Farup, Jean

    2016-01-01

    IntroductionIn this study we investigated the impact of whey protein hydrolysate and maltodextrin (WPH) intake on intramuscular connective tissue (IMCT) protein fractional synthesis rate (FSR) after maximal shortening and lengthening contractions. Methods Twenty young men were randomized to receive...... either WPH or maltodextrin [carbohydrate (CHO)] immediately after completion of unilateral shortening and lengthening knee extensions. Ring-13C6-phenylalanine was infused, and muscle biopsies were obtained. IMCT protein FSR was measured at 1–5, as well as 1–3 and 3–5 hours after contractions and nutrient...

  1. Artesunate Suppositories versus Intramuscular Artemether for Treatment of Severe Malaria in Children in Papua New Guinea

    OpenAIRE

    Karunajeewa, Harin A.; Reeder, John; Lorry, Kerry; Dabod, Elizah; Hamzah, Juliana; Page-Sharp, Madhu; Chiswell, Gregory M.; Ilett, Kenneth F.; Davis, Timothy M. E.

    2006-01-01

    Drug treatment of severe malaria must be rapidly effective. Suppositories may be valuable for childhood malaria when circumstances prevent oral or parenteral therapy. We compared artesunate suppositories (n = 41; 8 to 16 mg/kg of body weight at 0 and 12 h and then daily) with intramuscular (i.m.) artemether (n = 38; 3.2 mg/kg at 0 h and then 1.6 mg/kg daily) in an open-label, randomized trial with children with severe Plasmodium falciparum malaria in Papua New Guinea (PNG). Parasite density a...

  2. Intramuscular pressure and EMG relate during static contractions but dissociate with movement and fatigue

    DEFF Research Database (Denmark)

    Sjøgaard, Gisela; Jensen, Bente R.; Hargens, Allan R.

    2004-01-01

    Intramuscular pressure (IMP) and electromyography (EMG) mirror muscle force in the nonfatigued muscle during static contractions. The present study explores whether the constant IMP-EMG relationship with increased force may be extended to dynamic contractions and to fatigued muscle. IMP and EMG...... with speed of abduction. In the nonfatigued supraspinatus muscle, a linear relationship was found between IMP and EMG; in contrast, during fatigue and recovery, significant timewise changes of the IMP-to-EMG ratio occurred. The results indicate that IMP should be included along with EMG when mechanical load...... sharing between muscles is evaluated during dynamic and fatiguing contractions....

  3. Comparative study of oral and intramuscular atropine sulphate as a premedicant in paediatric age group.

    Directory of Open Access Journals (Sweden)

    Chaudhari L

    1989-01-01

    Full Text Available The use of atropine sulphate in the paediatric age group as a premedicant orally in a dosage of 0.02 mg/kg body weight 70 minutes prior to surgery was found to be as effective as atropine sulphate given intramuscularly 35 minutes prior to surgery in a dosage of 0.01 mg/kg body weight. This avoids the unpleasant memory of needle prick; The duration of effect as studied in the normal healthy children not subjected to surgery was found to be 2 1/2-3 hours.

  4. Intramuscular fatty acid metabolism in contracting and non-contracting human skeletal muscle

    DEFF Research Database (Denmark)

    Sacchetti, M; Saltin, B; Osada, T

    2002-01-01

    The present study was undertaken to investigate the fate of blood-borne non-esterified fatty acids (NEFA) entering contracting and non-contracting knee extensor muscles of healthy young individuals. [U-(13)C]-palmitate was infused into a forearm vein during 5 h of one-legged knee extensor exercis...... at 40 % of maximal work capacity and the NEFA kinetics, oxidation and rate of incorporation into intramuscular triacylglycerol (mTAG) were determined for the exercising and the non-exercising legs. During 4 h of one-legged knee extensor exercise, mTAG content decreased by 30 % (P

  5. Evaluation of calcium di-sodium EDTA intramuscular injection using gamma scintigraphy against heavy metal poisoning

    International Nuclear Information System (INIS)

    Kumar, N.; Soni, S.; Mehra, L.; Mittal, G.; Nishad, D.K.; Bhatnagar, A.; Singh, T.; Ahmad, F.J.

    2010-01-01

    Full text: Heavy metals become toxic when they are not metabolized by the body and accumulate in soft tissues. These metals may enter the body through food, water, air or absorption through skin when an individual is exposed to areas with high heavy metal content such as agriculture, pharmaceutical manufacturing, paint and heavy metal industries or residential settings. Majority of population commonly get affected by heavy metal poisoning. Heavy metal poisoning is more likely to result through inhalation or ingestion route. Aim of the present study is to provide an easy, effective and controlled chelating therapy against heavy metal using Ca-disodium EDTA intramuscular injection. Ca-disodium-EDTA and Sesame oil were procured from Merck, India and Sigma Aldrich, USA respectively. Ca-Na 2 EDTA radiolabeling with 99m Tc-pertechnetate was standardized using stannous ions as reducing agent. The hypothesis of present work is to maintain effective concentration of chelating agent in blood for prolong time period. To test this hypothesis, we studied 1% Ca-Na 2 EDTA blood bioavailability after intramuscular depot administration in new zealand white rabbit. The optimized radiolabeled intramuscular formulation was evaluated for its dissolution and permeation studies in isotonic buffer solution were envisaged through radiometry. Sub-acute toxicity studies were performed after a single dose intramuscular administration of 1% Ca-Na 2 EDTA in Sprague Dawley rats. Radiolabeled Ca-disodium-EDTA (>95% labeled) was found to be fairly stable up to 24 h in physiological solution (Serum) as well as in normal saline with negligible degradation of 2.5% and 5.0% respectively, thereby indicating high stability of radiolabeled product. In-vitro data indicates that control release pattern (Cmax 24 hrs) with effective concentration up to seven days. 99m Tc-CaNa 2 EDTA retention at depot site was estimated up to 3 days by scintigraphy. Subacute toxicity studies done by histopathological

  6. Soft tissue pseudotumor following intramuscular injection of 'DPT': A pitfall in magnetic resonance imaging

    International Nuclear Information System (INIS)

    Huber, D.J.; Sumers, E.; Klein, M.; State Univ. of New York, Stony Brook

    1987-01-01

    We report the time-dependent magnetic resonance imaging (MRI) changes that resulted from an intramuscular injection of a commonly-used pediatric sedation regiment ('DPT'). These changes at the site of injection consist of a focal abnormality characterized by a slight increase in signal intensity on T1 weighted images and markedly increased signal intensity on T2 weighted images. Alterations in signal are detectable almost immediately after the injection and progress over the first 31 hours. This abnormality, which could be mistaken for real disease, persists up to 36 days following injection. (orig.)

  7. [Intramuscular myxoma].

    Science.gov (United States)

    Parmeggiani, A; Gentile, R; Castellaneta, A

    1996-02-01

    Intramuscolar mixoma is a rare benign neoplasm of mesenchymal origin consisting of stellate shaped cells in an abundant loose, mucopolysaccharide rich matrix. We report two cases of intramuscolar mixoma with review of the literature. Our objectives are to delineate the clinico pathologic characteristic, the nature of constituent cells and the features differing from others benign and malignant neoplasms.

  8. PORCIONAMENTO, CONSUMO E DESPERDÍCIO EM UM RESTAURANTE ESCOLAR

    Directory of Open Access Journals (Sweden)

    Telma de Oliveira

    2012-06-01

    Full Text Available A qualidade e quantidade dos alimentos ingeridos pela criança são essenciais, nos primeiros anos de vida, e acarretam repercussões nas práticas alimentares, ao longo desta. O objetivo deste estudo foi avaliar, durante cinco dias, o porcionamento de alimentos, o consumo médio e o desperdício, em um restaurante de unidade escolar particular do município de São Paulo, com crianças de 5 a 6 anos, em  2011. O consumo alimentar variou entre 120,8 e 243,7g, a porcentagem de sobras de saladas entre 35,9 e 97,5%, e os restos entre 22,6 e 49,1%. Concluiu-se que o porcionamento variou de acordo com o funcionário que prepara o prato e não de acordo com o apetite ou vontade da criança. É importante que, além do conhecimento do per capita próprio, para essa faixa etária, estabeleça-se um sistema de self service para que a criança crie o seu próprio padrão de consumo.

  9. Um crime delicado: conversando aos infinitos - "Um retrato de cavalo"

    Directory of Open Access Journals (Sweden)

    Cid Ottoni Bylaardt

    2010-12-01

    um cavalo e seu retrato, a partir dos sentimentos contraditórios de seu dono, que considera um crime aquele clique. Temos aí um retrato, imagem subtraída ilicitamente ao seu dono: escrita, representação. Temos também uma narrativa, escrita do retrato, representação da representação. Este artigo pretende mostrar como Guimarães Rosa manipula as ambiguidades da linguagem literária, levando-a além dos limites da representação, explorando seu fascínio, seu saber, que não é da ordem da compreensão. O cavalo e seu retrato fazem refletir sobre a literatura, sobre seu excesso de verdade que compõe sua mentira. Ao escrever o cavalo e seu retrato, o texto não consegue fixar nenhuma verdade, apenas imagens fugidias que compõem recapítulos: há sempre um escrito a se sobrepor a outro, sem determinar onde está o verdadeiro, onde está o que o nega, a remeter o olhar ao reino da fascinação, onde a imagem perde o valor de significação para se tornar pura paixão da indeterminação, da indiferença.

  10. A psicologia histórico-cultural soviética (1917-1991: problemas de paternidade associados a obras e autores importantes

    Directory of Open Access Journals (Sweden)

    Roberto Valdés Puentes

    2017-02-01

    Full Text Available Resumo: Mukhina e Venguer estão envolvidos em problemas de “paternidade”. Chegou-se a conclusão que os livros Temas de psicologia pré-escolar e Psicologia Pré-escolar, publicados por Venguer e Mukhina, respectivamente, são praticamente um único livro devido a seu conteúdo. Em tal sentido, recomenda-se que os autores sejam adequadamente citados, com base na edição específica, acrescida, no segundo caso, da problematização que existe em torno dessas obras e autores, bem como de uma posição que assumidamente reconheça que essas ideias e produções pertencem a dois cientistas diferentes. Palavras-chave: Psicologia Histórico-cultural. Ex-União Soviética. Petrovsky. Mukhina. Venguer.

  11. Nutrição e VIH/SIDA como é importante... : Monografia : Nutrition and HIV/AIDS How important is...

    OpenAIRE

    Castro, Ema Daniela Rocha de

    2009-01-01

    Resumo da tese: As estimativas indicam que a infecção por VIH já causou cerca de 25 milhões de mortes em todo o mundo. Um dos determinantes críticos das respostas imunitárias é a nutrição. Sendo a desnutrição por sua vez, uma das maiores complicações da infecção por VIH. A desnutrição nos indivíduos que vivem com VIH surge por vários factores, nomeadamente ingestão alimentar reduzida, perda de nutrientes, alterações metabólicas e interacções entre fármacos e alimentos. O sinal mais comum de i...

  12. Haematological and biochemical alterations caused by epidural and intramuscular administration of xylazine hydrochloride in dromedary camels (Camelus dromedarius).

    Science.gov (United States)

    Azari, Omid; Molaei, Mohammad Mahdi; Emadi, Ladan; Sakhaee, Ehsanollah; Sharifi, Hamid; Mehdizadeh, Sara

    2012-01-01

    This study was conducted in 16 healthy immature dromedary camels weighing 120-150 kg to evaluate and compare the effects of epidural and intramuscular injections of xylazine administered at 0.1 mg/kg and 0.2 mg/kg. Haematological parameters included haemoglobin, packed cell volume, total erythrocyte count and total leukocyte count. Biochemical parameters included alkaline phosphates, alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, creatinine and glucose. Parameters were measured at different intervals before (baseline) and after the administration of drugs. Our study showed that the effect of xylazine on haematological and biochemical parameters is dose-dependant and is also related to the route of administration. The low dose of xylazine administered using both intramuscular and epidural methods showed minimal effects, whereas high doses of the drug, especially when injected intramuscularly, caused greater changes in haematological and biochemical parameters.

  13. Haematological and biochemical alterations caused by epidural and intramuscular administration of xylazine hydrochloride in dromedary camels (Camelus dromedarius

    Directory of Open Access Journals (Sweden)

    Omid Azari

    2012-09-01

    Full Text Available This study was conducted in 16 healthy immature dromedary camels weighing 120-150 kg to evaluate and compare the effects of epidural and intramuscular injections of xylazine administered at 0.1 mg/kg and 0.2 mg/kg. Haematological parameters included haemoglobin, packed cell volume, total erythrocyte count and total leukocyte count. Biochemical parameters included alkaline phosphates, alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, creatinine and glucose. Parameters were measured at different intervals before (baseline and after the administration of drugs. Our study showed that the effect of xylazine on haematological and biochemical parameters is dose-dependant and is also related to the route of administration. The low dose of xylazine administered using both intramuscular and epidural methods showed minimal effects, whereas high doses of the drug, especially when injected intramuscularly, caused greater changes in haematological and biochemical parameters.

  14. Acerca del cáncer cervicouterino como un importante problema de salud pública About uterocervical cancer as an important public health problem

    Directory of Open Access Journals (Sweden)

    Julio César Espín Falcón

    2012-12-01

    Full Text Available El cáncer se presenta como un importante problema de salud, dada la alta morbilidad y mortalidad que produce. Es uno de los procesos más complejos de la naturaleza y resulta el más complicado en la esfera de la medicina por su origen multicausal, la complejidad de sus mecanismos patogénicos y la variedad de formas y tipos que pueden originarse en el ser vivo. El objetivo de este trabajo es ofrecer información útil y actualizada acerca del cáncer cervicouterino. Esta enfermedad es prevenible y curable y se relaciona con la aparición del cáncer en vagina, cuello uterino, vulva y ano; en las mujeres se ha demostrado que la infección por el virus del papiloma humano es un factor de riesgo para su desarrollo. En la actualidad existen y se comercializan en el mundo dos tipos de vacuna, lo que se considera uno de los mayores avances en la medicina preventiva moderna. La aplicación de estas vacunas profilácticas contra el virus del papiloma humano podría reducir la incidencia y mortalidad por cáncer cervicouterino. Esta enfermedad constituye una de las entidades con más impacto y repercusión sobre la salud femenina, particularmente en las mujeres jóvenes. Está considerada una enfermedad emergente desde hace escasos años y sus consecuencias sociales, humanas y económicas lo convierten en un problema importante de salud pública y de la humanidad.Cancer represents an important health problem due to its high morbidity and mortality. It is one of the most complex processes of nature and the most complicated in medicine because of its multiple cause origin, the complexity of its pathogenic mechanisms and the variety of forms and types that may adopt in the subject alive. The objective of this paper was to provide useful and updated information on the uterocervical cancer. This disease is preventable and curable; it is related to the occurrence of cancer in the vagina, the uterine neck, the vulva and the anus. It has been proved that human

  15. Fat embolism in liposuction and intramuscular grafts in rabbits Embolia gordurosa na lipoaspiração e enxertia intramuscular em coelhos

    Directory of Open Access Journals (Sweden)

    Victor Araujo Felzemburgh

    2012-05-01

    Full Text Available PURPOSE: To evaluate the effects of fat embolism in organs such as lung and liver. METHODS: Twenty rabbits underwent autologous intramuscular fat grafting in the right thigh after liposuction. The groups were determined according to the postoperative day that occurred in euthanasia: 60, 90 and 120 day. Then, lung and liver were excised and sent to the histopathology laboratory for analysis in search of late injury secondary to a prior event of fat embolism in the tissues. RESULTS: The results showed a change in the macroscopic sample with discoloration of the liver tissue heterogeneously. There were no changes consistent with embolic effect under the microscope. CONCLUSION: The option of performing a technique of fat grafting with a less traumatic surgical procedure can be considered protective against embolic events, with no impact to late embolic events on the tissues.OBJETIVO: Avaliar a repercussão da embolia gordurosa em órgãos como pulmão e fígado. MÉTODOS: Vinte coelhos foram submetidos à enxertia autóloga intramuscular de gordura em coxa direita após lipoaspiração. Os grupos foram determinados conforme os dias pós-operatórios (DPO em que ocorreu a eutanásia: 60 DPO, 90DPO, 120 DPO. Em seguida, o pulmão e o fígado foram ressecados e encaminhados ao laboratório de histopatologia para análise em busca de lesão tardia secundária a evento de embolia gordurosa prévia nos tecidos. RESULTADOS: Foi evidenciada uma alteração na amostra a analise macroscópica com alteração da coloração do tecido hepático de forma heterogênea. Não houve alterações compatíveis com repercussão de processo embólico à microscopia. CONCLUSÃO: A opção pela realização de uma técnica de lipoenxertia menos traumática e com pequeno tempo cirúrgico pode ser considerada protetora para eventos embólicos, não havendo repercussão embólica a tardiamente.

  16. Immunization of mice with gamma-irradiated intramuscularly injected schistosomula of Schistosoma mansoni

    International Nuclear Information System (INIS)

    Bickle, Q.D.; Taylor, M.G.; Doenhoff, M.J.; Nelson, G.S.

    1979-01-01

    The parameters involved in the induction of resistance against Schistosoma mansoni by injection of irradiated, artificially transformed schistosomula were studied in mice. Single intramuscular injections of 500 schistosomula exposed to radiation doses in the range 2.3 to 160 krad. resulted in significant protection ( in the range 20 to 50% as assessed by reduced worm burdens) against a challenge infection administered at intervals from 3 to 24 weeks post-vaccination. However, schistosomular irradiated with 20 krad. consistently resulted in better protection than those exposed to either higher or lower radiation doses despite the persistence of stunted adults from the infections irradiated with 2.3 krad. Vaccination with 40 krad. schistosomula resulted in significant protection in terms of reduced worm and tissue egg burdens and increased survival following lethal challenge. Varying the number of irradiated schistosomula, the frequency and route of their administration, the site of challenge and the strain of host all failed to enhance the level of resistance. However, percutaneously applied, irradiated cercariae were found to be more effective in stimulating resistance (60%) than intramuscularly injected, irradiated schistosomula (40%). (author)

  17. Riboflavin laurate nanosuspensions as an intramuscular injection for long-term riboflavin supplementation.

    Science.gov (United States)

    Du, Lina; Li, Guanglong; Jin, Yiguang; Wang, Lin; Xu, Qishou; Dong, Junxing

    2013-06-25

    The aim of this study was to prepare riboflavin laurate (RFL) nanosuspensions as an intramuscular injection for long-term riboflavin supplementation. Stable RFL nanosuspensions were obtained by injecting RFL/poloxamer solution in N,N-dimethyl formamide into a trehalose solution. Long soft nanostructures initially appeared and then tube-like rigid nanostructures were obtained after removal of solvents according to the transmission electron microscopic images. The nanosuspensions had narrow size distribution and the mean size was about 300 nm. Molecular self-assembly of RFL may drive the formation of nanostructures. RFL formed a monolayer at the air/water interface and poloxamer 188 could insert into the monolayer. The nanosuspensions were intramuscularly injected into rats to provide long-term riboflavin supplementation for more than 30 days in light of body weight, food intake, and urinary riboflavin. The nanosuspensions were also used to resist the riboflavin deficiency induced by methotrexate chemotherapy. RFL nanosuspensions are a promising nanomedicine for long-term riboflavin supplementation. Copyright © 2013 Elsevier B.V. All rights reserved.

  18. Inhibition of adipose tissue lipolysis increases intramuscular lipid and glycogen use in vivo in humans.

    Science.gov (United States)

    van Loon, Luc J C; Thomason-Hughes, Michaela; Constantin-Teodosiu, Dumitru; Koopman, René; Greenhaff, Paul L; Hardie, D Grahame; Keizer, Hans A; Saris, Wim H M; Wagenmakers, Anton J M

    2005-09-01

    This study investigates the consequences of inhibition of adipose tissue lipolysis on skeletal muscle substrate use. Ten subjects were studied at rest and during exercise and subsequent recovery under normal, fasting conditions (control trial, CON) and following administration of a nicotinic acid analog (low plasma free fatty acid trial, LFA). Continuous [U-13C]palmitate and [6,6-2H2]glucose infusions were applied to quantify plasma free fatty acid (FFA) and glucose oxidation rates and to estimate intramuscular triacylglycerol (IMTG) and glycogen use. Muscle biopsies were collected to measure 1) fiber type-specific IMTG content; 2) allosteric regulators of hormone-sensitive lipase (HSL), glycogen phosphorylase, and pyruvate dehydrogenase; and 3) the phosphorylation status of HSL at Ser563 and Ser565. Administration of a nicotinic acid analog (acipimox) substantially reduced plasma FFA rate of appearance and subsequent plasma FFA concentrations (P glycogen use. Differential phosphorylation of HSL or relief of its allosteric inhibition by long-chain fatty acyl-CoA could not explain the increase in muscle TG use, but there was evidence to support the contention that regulation may reside at the level of the glucose-fatty acid cycle. This study confirms the hypothesis that plasma FFA availability regulates both intramuscular lipid and glycogen use in vivo in humans.

  19. Initial intramuscular perfusion pressure predicts early skeletal muscle function following isolated tibial fractures

    Directory of Open Access Journals (Sweden)

    Haas Norbert P

    2008-04-01

    Full Text Available Abstract Background The severity of associated soft tissue trauma in complex injuries of the extremities guides fracture treatment and decisively determines patient's prognosis. Trauma-induced microvascular dysfunction and increased tissue pressure is known to trigger secondary soft tissue damage and seems to adversely affect skeletal muscle function. Methods 20 patients with isolated tibial fractures were included. Blood pressure and compartment pressure (anterior and deep posterior compartment were measured continuously up to 24 hours. Corresponding perfusion pressure was calculated. After 4 and 12 weeks isokinetic muscle peak torque and mean power of the ankle joint in dorsal and plantar flexion were measured using a Biodex dynamometer. Results A significant inverse correlation between the anterior perfusion pressure at 24 hours and deficit in dorsiflexion at 4 weeks was found for both, the peak torque (R = -0.83; p Conclusion The functional relationship between the decrease in intramuscular perfusion pressures and muscle performance in the early rehabilitation period indicate a causative and prognostic role of early posttraumatic microcirculatory derangements and skeletal muscle function. Therapeutic concepts aimed at effective muscle recovery, early rehabilitation, and decreased secondary tissue damage, should consider the maintenance of an adequate intramuscular perfusion pressure.

  20. Concentrations of gentamicin in bronchial secretions after intramuscular and endotracheal administration.

    Science.gov (United States)

    Odio, W; Van Laer, E; Klastersky, J

    1975-07-01

    A crossover study was performed in five adult tracheotomized patients without respiratory tract disease to investigate the tracheobronchial kinetics of intramuscularly and endotracheally administered gentamicin in the absence of infection. Although intramuscular injection of 2 mg/kg of gentamicin yielded adequate levels in the serum, the concentrations in the bronchial secretions of noninfected patients were not adequate to inhibit strains of Pseudomonas aeruginosa isolated from other patients with clinical infections. Conversely, endotracheally administered gentamicin resulted in high and sustained concentrations in the bronchial secretions that were many times superior to the minimum bactericidal concentration of gentamicin against Pseudomonas aeruginosa. Gentamicin administered by aerosols resulted in concentrations within the bronchial secretions and sputum that were adequate to kill more than 90 per cent of the strains of Pseudomonas aeruginosa isolated in this hosopital. These studies suggest that endotracheally administered gentamicin might prove to be an adequate adjunct for the treatment of severe Pseudomonas infection of the tracheobronchial tract, particularly in the absence of foreight bodies and abnormalities of structure or function.

  1. A comparison of the effect of intramuscular diclofenac, ketorolac or piroxicam on postoperative pain following laparoscopy.

    Science.gov (United States)

    O'Hanlon, J. J.; Beers, H.; Huss, B. K.; Milligan, K. R.

    1996-01-01

    Sixty patients presenting for in-patient gynaecological laparoscopic surgery were randomly allocated to receive either diclofenac 75 mg (n = 20), ketorolac 30 mg (n = 20) or piroxicam 20 mg (n = 20) as an intra-muscular injection immediately after induction of anaesthesia. Postoperative visual analogue scores over the first 24 hours, using a 10 cm scale, ranged from 3.2-0.5 in the diclofenac group, 2.7-0.85 in the ketorolac group and 2.8-0.5 in the piroxicam group. The scores did not differ significantly between the three groups (p > 0.05). Mean time (SD) to first analgesia was 27(94) minutes in the piroxicam group, 16 (30) minutes in the diclofenac group and 62 (120) minutes in the piroxicam group. Six out of twenty patients in the diclofenac group required further analgesia compared to nine out of twenty in the other two drug groups. This difference was not significant. There were no reports of increased bleeding, bronchoconstriction, bleeding from the upper gastrointestinal tract, renal impairment or pain from the intra-muscular injection site in any of the groups. The administration of a non-steroidal anti-inflammatory drug to patients presenting for laparoscopic surgery reduces postoperative pain. There were no obvious differences between the agents used. PMID:8686101

  2. Pharmacokinetics of buprenorphine following intravenous and intramuscular administration in male rhesus macaques (Macaca mulatta)

    Science.gov (United States)

    Kelly, Kristi R.; Pypendop, Bruno H.; Christe, Kari L.

    2014-01-01

    This study reports the pharmacokinetics of buprenorphine in conscious rhesus macaques (Macaca mulatta) after intravenous (IV) and intramuscular (IM) administration. Four healthy, opioid-naïve, socially-housed, adult male macaques were used. Buprenorphine (0.03 mg/kg) was administered intravenously as a bolus or intramuscularly on separate occasions. Blood samples were collected prior to, and up to 24 h, post-administration. Serum buprenorphine concentrations were analyzed with liquid chromatography-mass spectrometry. Noncompartmental pharmacokinetic analysis was performed with commercially available software. Mean residence time in the IV study as compared to the IM study was 177 (159–189) minutes vs. 185 (174–214) minutes, respectively [median (range)]. In the IV study, concentration back extrapolated to time zero was found to be 33.0 (16.8–57.0) ng/mL [median (range)]. On the other hand, the maximum serum concentration found in the IM study was 11.8 (6.30–14.8) ng/mL [median (range)]. Rhesus macaques maintained concentrations greater than 0.10 ng/mL for over 24 h in the IV study and over 12 h in the IM study. Bioavailability was found to be 68.1 (59.3–71.2)% [median (range)]. No significant adverse effects were observed in the monkeys at the 0.03 mg/kg dose of buprenorphine during either study. PMID:24666428

  3. [Differential diagnosis and management of intramuscular myxomas: A review of our experience].

    Science.gov (United States)

    Granel-Villach, Laura; Alcalde-Sánchez, Miguel; Salvador-Marín, Manuel; García-Calvo, Rafael; Santonja-López, Nuria; Salvador-Sanchís, José Luis

    Intramuscular myxoma is a rare benign soft tissue tumour of mesenchymal origin, which appears as a painless mass of slow growth. Early diagnosis is important in order to differentiate it from other entities, especially soft tissue sarcoma. Two cases, both women with a mean age of 52.5 years (range 40-65) are presented. The first was seen due to growth of a gluteal mass, and the second by coccydynia. Computed tomography and nuclear magnetic resonance were the diagnostic tests of choice. In one case, where there was a single but large lesion, radical extirpation of the gluteal muscle was chosen. In the other case, in which the lesions were multiple, individualised excision of cysts was performed. Postoperative functional limitation was low in both types of surgery, with good oncological results being obtained. Intramuscular myxomas are benign lesions. There are no cases of malignancy or recurrence due to incomplete resection. It has to be determined whether they are single or multiple, since in the latter case, they could be due to syndromes such as Mazabraud syndrome, which is associated with bone fibrous dysplasia, or Albright syndrome that is also associated with pigmented skin spots. Copyright © 2016 Academia Mexicana de Cirugía A.C. Publicado por Masson Doyma México S.A. All rights reserved.

  4. Comparing performance of amoxicillin and intramuscular benzathine penicillin in relieving manifestations of streptococcal pharyngitis in children.

    Science.gov (United States)

    Eslami, S T; Nassirian, A; Nassirian, H; Hatami, E; Sobhani, E; Najibpour, R

    2014-12-01

    To compare clinical and bacteriologic responses to intramuscular benzathine penicillin G (BPG) and single dose of amoxicillin in Group A streptococcal (GAS) pharyngitis. This study included 571 children from 6 to 15 years old age, with pharyngitis, who were admitted to 45 elementary and guidance schools from 7 regions of Education Organization in North-East of Iran, Mashhad. They were screened for enrollment and if he/she presented pharyngitis with clinical criteria of sore throat, erythema, exudate and tender or enlarged anterior cervical lymph nodes. Exclusion criteria included reports of antibiotic use, negative throat culture for GAS and history of allergy to the drugs. Clinical and bacteriologic responses to BPG and once daily orally amoxicillin were considered and compared. In the amoxicillin group, treatment failure was more than the penicillin group (18.9% vs. 6.4%, respectively) but the difference was not statistically significant (p amoxicillin. Our study was in line with studies comparing the two drugs. The results show that once-daily therapy with amoxicillin is as effective as intramuscular benzathine penicillin G for the treatment of GAS pharyngitis, but penicillin was significantly more effective in reducing exudate and concurrent signs vs. amoxicillin.

  5. Concomitant intramuscular human chorionic gonadotropin preserves spermatogenesis in men undergoing testosterone replacement therapy.

    Science.gov (United States)

    Hsieh, Tung-Chin; Pastuszak, Alexander W; Hwang, Kathleen; Lipshultz, Larry I

    2013-02-01

    Testosterone replacement therapy results in decreased serum gonadotropins and intratesticular testosterone, and impairs spermatogenesis, leading to azoospermia in 40% of patients. However, intratesticular testosterone can be maintained during testosterone replacement therapy with co-administration of low dose human chorionic gonadotropin, which may support continued spermatogenesis in patients on testosterone replacement therapy. We retrospectively reviewed the records of hypogonadal men treated with testosterone replacement therapy and concomitant low dose human chorionic gonadotropin. Testosterone replacement consisted of daily topical gel or weekly intramuscular injection with intramuscular human chorionic gonadotropin (500 IU) every other day. Serum and free testosterone, estradiol, semen parameters and pregnancy rates were evaluated before and during therapy. A total of 26 men with a mean age of 35.9 years were included in the study. Mean followup was 6.2 months. Of the men 19 were treated with injectable testosterone and 7 were treated with transdermal gel. Mean serum hormone levels before vs during treatment were testosterone 207.2 vs 1,055.5 ng/dl (p human chorionic gonadotropin therapy. Nine of 26 men contributed to pregnancy with the partner during followup. Low dose human chorionic gonadotropin appears to maintain semen parameters in hypogonadal men on testosterone replacement therapy. Concurrent testosterone replacement and human chorionic gonadotropin use may preserve fertility in hypogonadal males who desire fertility preservation while on testosterone replacement therapy. Copyright © 2013 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  6. Inflammatory responses following intramuscular and subcutaneous immunization with aluminum-adjuvanted or non-adjuvanted vaccines.

    Science.gov (United States)

    Kashiwagi, Yasuyo; Maeda, Mika; Kawashima, Hisashi; Nakayama, Tetsuo

    2014-06-05

    Aluminum-adjuvanted vaccines are administered through an intramuscular injection (IM) in the US and EU, however, a subcutaneous injection (SC) has been recommended in Japan because of serious muscle contracture previously reported following multiple IMs of antibiotics. Newly introduced adjuvanted vaccines, such as the human papillomavirus (HPV) vaccines, have been recommended through IM. In the present study, currently available vaccines were evaluated through IM in mice. Aluminum-adjuvanted vaccines induced inflammatory nodules at the injection site, which expanded into the intra-muscular space without any muscle degeneration or necrosis, whereas non-adjuvanted vaccines did not. These nodules consisted of polymorph nuclear neutrophils with some eosinophils within the initial 48h, then monocytes/macrophages 1 month later. Inflammatory nodules were observed 6 months after IM, had decreased in size, and were absorbed 12 months after IM, which was earlier than that after SC. Cytokine production was examined in the injected muscular tissues and AS04 adjuvanted HPV induced higher IL-1β, IL-6, KC, MIP-1, and G-CSF levels in muscle tissues than any other vaccine, but similar serum cytokine profiles were observed to those induced by the other vaccines. Currently available vaccines did not induce muscular degeneration or fibrotic scar as observed with muscle contracture caused by multiple IMs of antibiotics in the past. Copyright © 2014 Elsevier Ltd. All rights reserved.

  7. A randomized controlled trial of sublingual misoprostol and intramuscular oxytocin for prevention of postpartum hemorrhage.

    Science.gov (United States)

    Priya, G Prema; Veena, P; Chaturvedula, Latha; Subitha, L

    2015-12-01

    In India, two third of maternal deaths occur in rural areas where there is lack of transportation facilities, lack of refrigeration to store the injectable uterotonic drug such as oxytocin, lack of skilled personnel to administer them and lack of sterile syringes and needles. Hence, this study was conceived to evaluate misoprostol as a safe, effective, easily administered non-parenteral drug in the prevention of postpartum hemorrhage. This study was conducted during the period from August 2012 to July 2014. Low risk women with singleton pregnancy at term admitted for vaginal delivery were eligible for the study. A total of 500 women were randomized to two groups, 250 in each group, either to receive 400 mcg misoprostol sublingually or 10 units oxytocin intramuscularly at the delivery of anterior shoulder. Patient factors, labor parameters, blood loss and side effects were noted. The women in both the groups were well matched with respect to age, parity, gestational age and labor parameters. There was statistical significance in the blood loss (p = 0.04) between the two groups. The average blood loss was 70 ml in misoprostol group and 75 ml in oxytocin group. Shivering was the statistically significant side effect (p = 0.004) in the misoprostol group and nausea was the statistically significant side effect (p = 0.003) in the oxytocin group. Sublingual misoprostol is as effective as intramuscular oxytocin as a prophylactic oxytocic in the active management of third stage of labor for prevention of postpartum hemorrhage.

  8. Pharmacokinetics of oral transmucosal and intramuscular dexmedetomidine combined with buprenorphine in cats.

    Science.gov (United States)

    Porters, N; de Rooster, H; Bosmans, T; Baert, K; Cherlet, M; Croubels, S; De Backer, P; Polis, I

    2015-04-01

    Plasma concentrations and pharmacokinetics of dexmedetomidine and buprenorphine after oral transmucosal (OTM) and intramuscular (i.m.) administration of their combination in healthy adult cats were compared. According to a crossover protocol (1-month washout), a combination of dexmedetomidine (40 μg/kg) and buprenorphine (20 μg/kg) was given OTM (buccal cavity) or i.m. (quadriceps muscle) in six female neutered cats. Plasma samples were collected through a jugular catheter during a 24-h period. Plasma dexmedetomidine and buprenorphine concentrations were determined by liquid chromatography-tandem mass spectrometry. Plasma concentration-time data were fitted to compartmental models. For dexmedetomidine and buprenorphine, the area under the plasma concentration-time curve (AUC) and the maximum plasma concentrations (Cmax ) were significantly lower following OTM than following i.m. administration. For buprenorphine, time to reach Cmax was also significantly longer after OTM administration than after i.m. injection. Data suggested that dexmedetomidine (40 μg/kg) combined with buprenorphine (20 μg/kg) is not as well absorbed from the buccal mucosa site as from the intramuscular injection site. © 2014 John Wiley & Sons Ltd.

  9. Predictive efficiency of distinct color image segmentation methods for measuring intramuscular fat in beef

    Directory of Open Access Journals (Sweden)

    Renius Mello

    2015-10-01

    Full Text Available Intramuscular fat (IMF influences important quality characteristics of meat, such as flavor, juiciness, palatability, odor and tenderness. Thus, the objective of this study was to apply the following image processing techniques to quantify the IMF in beef: palette; sampling, interval of coordinates; black and white threshold; and discriminant function of colors. Thirty-five samples of beef, with a wide range of IMF, were used. Color images were taken of the meat samples from different muscles, with variability in the IMF content. The IMF of a thin cross-section meat was determined by chemical lipid extraction and was predicted by image analysis. The chemical method was compared with the image analysis. The segmentation procedures were validated by the adjustment of a linear regression equation to the series of values that were observed and predicted, as well as the regression parameters evaluated by the F-test. The predictive power of these approaches was also compared by residual analysis and by the decomposition of the mean square deviations. The results showed that the discriminant function was the best color segmentation method to measure intramuscular fat via digital images, but required adjustments in the prediction pattern.

  10. Intramuscular inoculation of cattle with Sarcocystis antigen results in focal eosinophilic myositis.

    Science.gov (United States)

    Vangeel, L; Houf, K; Geldhof, P; Nollet, H; Vercruysse, J; Ducatelle, R; Chiers, K

    2012-02-10

    Bovine eosinophilic myositis (BEM) is a subclinical myopathy characterized by multifocal white to grey-green discolorations in skeletal muscles, heart, tongue and oesophagus. These lesions are found at slaughter or during meat cutting and result in considerable economic losses. The etiology and pathogenesis are unclear, although it has been suggested, that Sarcocystis species are involved. To elucidate their role, two calves were repeatedly injected intramuscularly with adjuvanted Sarcocystis antigen. The morphological changes at the injection sites in these calves were histologically and immunohistochemically compared to spontaneous lesions from 44 BEM condemned carcasses sampled in slaughterhouses. Experimental intramuscular injection of Sarcocystis antigen resulted in lesions at the injection sites that were similar to the lesions of natural cases of BEM. They were characterized by massive infiltration of eosinophilic granulocytes, reactive macrophages (MAC387(+) cells), T-cells (CD3(+)) and B-cells (CD20(+)). Both in the experimental and in the natural cases, COX-2 expression was present in endothelial cells adjacent to lesional areas. MHC class II(+) staining was found amongst others in muscle cells surrounding the lesion. These results show that Sarcocystis antigens can induce an inflammatory response in bovine muscle having the characteristics of natural BEM. Copyright © 2011 Elsevier B.V. All rights reserved.

  11. Liver metabolism traits in two rabbit lines divergently selected for intramuscular fat.

    Science.gov (United States)

    Martínez-Álvaro, M; Paucar, Y; Satué, K; Blasco, A; Hernández, P

    2017-10-26

    Intramuscular fat (IMF) has a large effect in the sensory properties of meat because it affects tenderness, juiciness and flavour. A divergent selection experiment for IMF in longissimus dorsi (LD) muscle was performed in rabbits. Since liver is the major site of lipogenesis in rabbits, the objective of this work is to study the liver metabolism in the lines of the divergent selection experiment. Intramuscular fat content, perirenal fat weight, liver weight, liver lipogenic activities and plasma metabolites related to liver metabolism were measured in the eighth generation of selection. Direct response on IMF was 0.34 g/100 g of LD, which represented 2.7 SD of the trait, and selection showed a positive correlated response in the perirenal fat weight. High-IMF line showed greater liver size and greater liver lipogenic activities of enzymes glucose-6-phosphate dehydrogenase and malic enzyme. We did not find differences between lines for fatty acid synthase lipogenic activity. With regard to plasma metabolites, low-IMF line showed greater plasma concentration of triglycerides, cholesterol, bilirubin and alkaline phosphatase than high-IMF line, whereas high-IMF line showed greater albumin and alanine transaminase concentrations than low-IMF line. We did not observe differences between lines for glucose, total protein and plasma concentrations. Phenotypic correlations between fat (IMF and perirenal fat weight) and liver traits showed that liver lipogenesis affects fat deposition in both, muscle and carcass. However, the mechanisms whereby liver lipogenesis affected IMF content remain to be clarified.

  12. Treatment of reno-ureteral colic by twelfth intercostal nerve block with lidocaine versus intramuscular diclofenac.

    Science.gov (United States)

    Maldonado-Avila, Miguel; Del Rosario-Santiago, Marcos; Rosas-Nava, Jesus Emmanuel; Manzanilla-Garcia, Hugo Arturo; Rios-Davila, Victor Manuel; Rodriguez-Nava, Patricia; Vela-Mollinedo, Roberto Alejandro; Garduño-Arteaga, Mateo Leopoldo

    2017-03-01

    Renal colic is one of the most intense pains known to humans. Standard treatment usually consists of nonsteroidal anti-inflammatory drugs and opiates, but they do not always provide optimum efficacy and speed in relieving the pain. For more than 25 years, our hospital has been employing twelfth subcostal nerve block. The objective of the present study was to compare the efficacy of subcostal nerve block with lidocaine versus intramuscular diclofenac in renal colic management. Sixty patients of both sexes, above the age of 18 years, and presenting with renal colic were randomly selected for the study. The visual analog scale was applied prior to the treatment and at minutes 1, 3, 5, 30, and 45 after the application of the twelfth nerve block or the intramuscular administration of diclofenac. A total of 60 patients, 35 women and 25 men, were included in the study. There were statistically significant differences in the mean scores for pain from minute 1 to minute 45. There were no adverse effects. Twelfth Subcostal nerve block with lidocaine is an efficacious, safe, inexpensive, and very fast-acting medication for pain control related to renal colic. These characteristics make it superior to diclofenac.

  13. A Lipid Base Formulation for Intramuscular Administration of a Novel Sulfur Donor for Cyanide Antagonism.

    Science.gov (United States)

    Kovacs, Kristof; Jayanna, Prashanth K; Duke, Anna; Winner, Brittany; Negrito, Melaeni; Angalakurthi, Siva; Yu, Jorn C C; Füredi, Petra; Ludányi, Krisztina; Sipos, Peter; Rockwood, Gary A; Petrikovics, Ilona

    2016-01-01

    This study represents a new formulation of the novel Cyanide (CN) antidote, Dimethyl trisulfide (DMTS), for intramuscular administration. This is a naturally occurring organosulfur molecule with the capability of reacting with CN more efficiently than the present sulfur donor type CN therapy of Thiosulfate (TS). Two types of micelles (PEG2000-DSPE and PEG2000-DSPE/TPGS) were prepared and tested for their ability to encapsulate the liquid, highly lipophilic and volatile drug, DMTS. The micellar encapsulation for DMTS does not only eliminate the possible muscle necrosis at the injection sites, but the rate of evaporation within the micelles is suppressed, that can provide a level of stability for the formulation. The method of micelle preparation was optimized and it was demonstrated that the PEG2000-DSPE preparation can dissolve up to 2.0 mg/ml of the antidote candidate. Keeping the injection volume minimized this could provide a maximum DMTS dose of 12.5 mg/kg. However, even this low dose of DMTS showed a remarkable in vivo therapeutic efficacy (2 X LD50 protection) in a mice model when injected intramuscularly. These in vitro and in vivo findings proved the efficacy of DMTS in combating CN intoxication, and the presented work gives valuable insight to micelle preparation and sets the bases for a more advanced future formulation of DMTS.

  14. Low-Dose Intramuscular Diclofenac Sodium for Fever Control in Acute Brain Injury.

    Science.gov (United States)

    Picetti, Edoardo; Servadei, Franco; Reverberi, Cristiana; De Carlo, Francesca; Rossi, Ilaria; Antonini, Marta Velia; Caspani, Maria Luisa

    2016-11-01

    To evaluate the cerebral and hemodynamic effects of low-dose intramuscular diclofenac sodium (DCFS) administered for fever control in patients with acute brain injury in the intensive care unit. Inclusion criteria for this prospective clinical study were age ≥18 years; the ability to monitor intra-arterial blood pressure, core body temperature, and intracranial pressure; the placement of an indwelling jugular venous catheter for intermittent jugular venous oxygen saturation measurements; and a core body temperature ≥37.5°C. Exclusion criteria were hypovolemia, administration of drugs with hemodynamic effects during the study period, administration of antipyretics within 6 hours before the start of the study, acute heart failure, cerebral vasospasm, pregnancy, renal and gastric diseases, and allergy to DCFS. The study enrolled 30 patients with acute brain injury. Two We observed statistically significant decreases in core body temperature (P administration with respect to baseline (T0). The dosage of noradrenaline (norepinephrine) in subjects receiving treatment at the start of the study increased significantly from 0.14 μg/kg/minute ± 0.1 to 0.20 μg/kg/minute ± 0.1 (P = 0.0395). Low-dose intramuscular DCFS administration for fever control in patients with acute brain injury is effective but also exposes patients to potentially deleterious hypotensive episodes that must be diagnosed and treated expeditiously to prevent further damage to the injured brain. Copyright © 2016 Elsevier Inc. All rights reserved.

  15. SEMIOSE DE UM PARADOXO COMUNICATIVO

    Directory of Open Access Journals (Sweden)

    Mauricius Martins Farina

    2008-06-01

    Full Text Available Este ensaio perscruta uma noção de real e de ficção em que ambos surgem como representação, num processo de semiose considerada um paradoxo comunicativo. O jornalismo contemporâneo é também uma mercadoria, um sistema complexo de comunicação, seu produto é a realidade construída com argumentos estereotipados por interesses editoriais pautados por interesses políticos e comerciais, simulacro de um conteúdo que não reflete, mas cria a necessidade no receptor. Também a realidade construída pelas imagens contemporâneas não é comunicação no sentido designativo, mas expressão de um simulacro que, como tal, ao negar a fantasia, recalca a realidade como uma ficção, operando num sistema de códigos numéricos que surgem como imagem num espaço visual transduzido da sua indexalidade para a virtualidade.

  16. Psicologia escolar: um duplo desafio

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    Luiza Elena Leite Ribeiro do Valle

    Full Text Available A educação representa a capacidade de um povo organizar-se e construir seu futuro, portanto, não se realiza ao acaso, mas como consequência de um esforço expressivo. A Psicologia Escolar pretende facilitar o desenvolvimento humano, mas ainda permanece pouco conhecida. O sucesso no desempenho do psicólogo escolar exige uma imagem clara de seus principais propósitos, enfrentando um duplo desafio: ser aceito na escola (sem ter seu papel limitado na busca da promoção do desenvolvimento infantil e ser apoiado na organização de atividades preventivas que afetam o curso do desenvolvimento da criança (envolvendo o desenvolvimento cognitivo, afetivo, social e físico e o enriquecimento da interação social da criança. Brevemente, o propósito deste estudo é focalizar de forma prática um campo mais eficiente, amplo e satisfatório para a Psicologia Escolar.

  17. SIMULINVE – Um simulador de inventário para um centro de distribuição de peças

    Directory of Open Access Journals (Sweden)

    Heráclito Lopes Jaguaribe Pontes

    2008-10-01

    Full Text Available No mercado globalizado atual, as empresas buscam garantir disponibilidade de produto ao cliente final, com o menor nível de inventário possível. As ferramentas de simulação disponibilizam aos gestores melhores visões do negócio e melhores condições para a tomada de decisão. Em um Centro de Distribuição de Peças (CDP, para se alcançar um melhor desempenho no gerenciamento do inventário é importante poder contar com uma ferramenta capacitada para realizações de simulações de possíveis cenários. Este trabalho teve como objetivo desenvolver um processo para gerenciamento de inventario que resultou em um simulador de inventário para CDP. O simulador realiza projeções visando obter como resultados a previsão de demanda, a política de reposição das peças, o percentual de atendimento dos pedidos, os meses de inventário, a quantidade de Scrap e a quantidade de peças. O simulador foi submetido a experimentos com três cenários diferentes e os resultados confirmaram a qualidade do sistema de simulação proposto.

  18. Um estudo comparativo entre dados sociodemográficos e neuroticismo

    OpenAIRE

    Mansueto Dal Maso; Fabio Biasotto Feitosa

    2013-01-01

    O neuroticismo tem sido referido como um importante indicador de saúde mental. O estudo do grau de neuroticismo em uma dada população pode ser estratégico para o planejamento de políticas e programas de saúde coletiva. O objetivo do presente estudo foi avaliar o neuroticismo em estudantes universitários do Estado de Rondônia. Participaram como sujeitos deste estudo de levantamento 1.031 universitários de ambos os sexos, entre 18 e 75 anos, que autoavaliaram seu grau de neuroticismo. Os dados ...

  19. Direito Ambiental: Natureza como um Bem da Humanidade ou como Sujeito de Direitos?

    OpenAIRE

    Gomes, Ariel Koch; UniRitter - Lareate International Universities

    2013-01-01

    O Direito e a sociedade ainda concebem a natureza meramente como objeto, bem comum da população, levando a proteção da natureza, única e exclusivamente, como algo importante para as presentes e futuras gerações de seres humanos. A pesquisa tem por objetivo, portanto, a análise da possibilidade de um paradigma contemporâneo que insira o Direito e o Homem dentro da Natureza em evolução e suas leis. Insere-se a investigação no quadro do debate contemporâneo sobre os problemas ambientais e a rela...

  20. Ser / estar junto juvenil na contemporaneidade: um olhar de Bauman e Maffesoli.

    Directory of Open Access Journals (Sweden)

    Nádia Jane de Sousa

    2012-07-01

    Full Text Available Discute a temática juventude e seus agrupamentos, apontando um modo de estar-junto, potencializador de socialidade. Tendo como eixo teórico a sociologia compreensiva de Michel Maffesoli em contraponto com ideias de Zygmunt Bauman, apresenta questões como identidade, sociedade da imagem, estilo e tribalização, como eixos importantes para a compreensão das transformações nas vivências sociais, especialmente entre os jovens, na atualidade.

  1. Modelagem matemática de um giroscópio sintonizado dinamicamente

    OpenAIRE

    Barros, Ettore Apolônio de; Junqueira, Fernando de Castro

    2005-01-01

    Este trabalho apresenta a modelagem matemática da dinâmica de operação de um giroscópio sintonizado dinamicamente, DTG. A obtenção das funções de transferência simplificada ocorre realçando-se os conceitos relacionados a parâmetros e fenômenos importantes no desempenho do sensor. This work describes the principle of operation and the motion dynamics of a dynamically tuned gyroscope, DTG. The complete set of equations of motion are derived, and a simplified representation for the transfer f...

  2. Intramuscular olanzapine versus intramuscular aripiprazole for the treatment of agitation in patients with schizophrenia: A pragmatic double-blind randomized trial.

    Science.gov (United States)

    Kittipeerachon, Mantana; Chaichan, Warawat

    2016-10-01

    To evaluate and compare the effectiveness and adverse effects of intramuscular (IM) olanzapine and IM aripiprazole for the treatment of agitated patients with schizophrenia in clinical practice. A 24-hour randomized double-blind study carried out at a psychiatric hospital in Thailand enrolled adult patients (18-65years old) with schizophrenia experiencing agitation. Patients received one dose of IM olanzapine or IM aripiprazole followed by routine oral psychotropic medications. Efficacy was primarily measured using the Excited Component of the Positive and Negative Syndrome Scale (PANSS-EC). A total of 80 patients with a PANSS-EC score range of 22-35 entered the study, of whom 13% had a medical comorbidity and 40% a history of active substance abuse. The 40 patients receiving IM olanzapine showed greater improvement than the 40 patients receiving IM aripiprazole in PANSS-EC scores at 2h after the injection (p=0.002) but not at 24h. The two treatments were well tolerated. Patients receiving IM olanzapine experienced greater somnolence than those receiving IM aripiprazole. There were no clinically relevant changes in vital signs in either group. The results indicate that IM olanzapine and aripiprazole are similarly effective and well tolerated in the real-world treatment of agitation associated with schizophrenia over the first 24h. However, in the early hours, IM olanzapine may produce more sedation and reductions in agitation. Copyright © 2016 Elsevier B.V. All rights reserved.

  3. Two Sudden and Unexpected Deaths of Patients with Schizophrenia Associated with Intramuscular Injections of Antipsychotics and Practice Guidelines to Limit the Use of High Doses of Intramuscular Antipsychotics

    Directory of Open Access Journals (Sweden)

    Nasratullah Wahidi

    2016-01-01

    Full Text Available Intravenous haloperidol has been associated with torsades de pointes (TdP. These two sudden deaths were probable adverse drug reactions (ADRs following intramuscular (IM antipsychotics. The autopsies described lack of heart pathology and were highly compatible with the possibility of TdP in the absence of risk factors other than the accumulation of antipsychotics with a high serum peak after the last injection, leading to death within hours. The first case was a 27-year-old African-American male with schizophrenia but no medical issues. His death was probably caused by repeated IM haloperidol injections of 10 mg (totaling 35 mg in 2 days. The second case involves a 42-year-old African-American female with metabolic syndrome. Her probable cause of death was the last ziprasidone IM injection of 20 mg in addition to (1 three extra haloperidol doses (2 hours before the ziprasidone injection, 5 mg oral haloperidol; approximately 21 hours earlier, 5 mg oral haloperidol; and 2 days prior, one 10 mg IM haloperidol injection, (2 10 mg/day of scheduled oral haloperidol for 6 days before death, and (3 a long-acting paliperidone injection of 156 mg 18 days before death. The study of haloperidol glucuronidation and its impairment in some African-Americans is urgently recommended.

  4. Acesso à Justiça Popular: Uma Importante Experiência Prático-Jurídica-Social Universitária

    Directory of Open Access Journals (Sweden)

    Idir Canzi

    2014-10-01

    Full Text Available http://dx.doi.org/10.5007/1807-0221.2014v11n17p51 O presente artigo centra o desenvolvimento de seu conteúdo na temática do acesso à justiça popular. Contextualiza primeiramente o acesso à Justiça Popular e o seu alcance no Brasil. Descreve as importantes contribuições da atuação do ESJ - Escritório Sócio-Jurídico da Unochapecó - Universidade Comunitária da Região de Chapecó - SC, enquanto instrumento de acesso à Justiça popular na Comarca de Xaxim – SC. Apresenta e analisa o rol de atendimentos e ações ajuizadas pelo ESJ em favor da população usuária dos serviços da Assistência jurídica integral e gratuita (artigo 5°, inciso LXXIV da Constituição Federal de 1988 e Lei 1060/50, a partir da execução de estruturada pesquisa documental, nas competências 2003 a 2011. Ainda, insere a análise dos resultados das decisões judiciais dos processos ajuizados pelo Escritório Sócio-Jurídico da Unochapecó nas competências anunciadas. Finaliza atestando que o Escritório Sócio-Jurídico da Unochapecó na Comarca de Xaxim, SC, contribui de forma efetiva para que a população usuária tenha respeitado o acesso à justiça e ao sistema judiciário, por meio do oferecimento qualificado de serviços sócio-jurídicos, com atuação de profissionais e estudantes em estágio curricular que acompanham administrativa e judicialmente a integralidade das demandas.

  5. Orientação de enfermagem: fator importante no ajustamento das mulheres mastectomizadas - contribuição à assistência de enfermagem

    Directory of Open Access Journals (Sweden)

    Zuila Maria de Figueiredo Carvalho

    1984-12-01

    Full Text Available Os problemas biopsicossócio-espirituais decorrentes da mutilação por mastec-tomia constituem motivo de preocupação para os profissionais de saúde, mais precisamente da enfermeira. O objetivo deste estudo foi identificar os problemas que interferem na adaptação familiar e social da cliente, antes e após a cirurgia. Esta pesquisa, exploratória, realizou-se em dois hospitais de oncologia da Cidade do Rio de Janeiro, envolvendo sessenta clientes com câncer de mama. A amostra constitui-se de três grupos, com vinte clientes cada um. A coleta dos dados efetuou-se mediante entrevista individual. Os resultados indicam a falta de orientação nos períodos pré e pós-operatórios, assim como problemas emocionais decorrentes da mutilação que afetam especialmente a vida sexual. O trabalho oferece subsídios para o planejamento de ações de enfermagem, visando o atendimento das necessidades apresentadas por essa clientela.

  6. Liver transcriptome profile in pigs with extreme phenotypes of intramuscular fatty acid composition

    Directory of Open Access Journals (Sweden)

    Ramayo-Caldas Yuliaxis

    2012-10-01

    Full Text Available Abstract Background New advances in high-throughput technologies have allowed for the massive analysis of genomic data, providing new opportunities for the characterization of the transcriptome architectures. Recent studies in pigs have employed RNA-Seq to explore the transcriptome of different tissues in a reduced number of animals. The main goal of this study was the identification of differentially-expressed genes in the liver of Iberian x Landrace crossbred pigs showing extreme phenotypes for intramuscular fatty acid composition using RNA-Seq. Results The liver transcriptomes of two female groups (H and L with phenotypically extreme intramuscular fatty acid composition were sequenced using RNA-Seq. A total of 146 and 180 unannotated protein-coding genes were identified in intergenic regions for the L and H groups, respectively. In addition, a range of 5.8 to 7.3% of repetitive elements was found, with SINEs being the most abundant elements. The expression in liver of 186 (L and 270 (H lncRNAs was also detected. The higher reproducibility of the RNA-Seq data was validated by RT-qPCR and porcine expression microarrays, therefore showing a strong correlation between RT-qPCR and RNA-Seq data (ranking from 0.79 to 0.96, as well as between microarrays and RNA-Seq (r=0.72. A differential expression analysis between H and L animals identified 55 genes differentially-expressed between groups. Pathways analysis revealed that these genes belong to biological functions, canonical pathways and three gene networks related to lipid and fatty acid metabolism. In concordance with the phenotypic classification, the pathways analysis inferred that linolenic and arachidonic acids metabolism was altered between extreme individuals. In addition, a connection was observed among the top three networks, hence suggesting that these genes are interconnected and play an important role in lipid and fatty acid metabolism. Conclusions In the present study RNA-Seq was used

  7. Gilberto Freyre: um teórico da globalização?

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    Debora Gerstenberger

    2014-03-01

    Full Text Available Gilberto Freyre é um dos mais importantes intelectuais e cientistas sociais brasileiros de todos os tempos. No entanto, ao contrário de Fernand Braudel, o famoso contemporâneo francês e colega seu, Freyre atualmente não é considerado um fundador da nova ‘história global’. A questão é: qual o valor da obra de Gilberto Freyre para a historiografia contemporânea? Já que a maioria de seus livros trata de temas como colonialismo, migração e a ‘miscigenação’ de diferentes etnias e culturas, será que também revela algo sobre o que chamamos hoje de globalização? Como historiadores, no âmbito da nova história global, podemos utilizar seus escritos para entender (melhor o passado? E, se assim for, como podemos aproveitar sua obra?

  8. O Corpo Deglutido No Banquete Polifônico De “Vozes De Um Túmulo”

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    Rogério Caetano de Almeida

    2016-07-01

    Full Text Available Este trabalho analisa o poema “Vozes de um túmulo”, de Augusto dos Anjos, a partir da ideia de que as vozes polifônicas, que influenciam e permeiam o eu lírico, transformam-se em parte de seu ser e de seu corpo. Este último é o que chamamos aqui de corpo grotesco. Os trabalhos teóricos que dão suporte a este estudo são os de Mikhail Bakhtin (mais especificamente as partes que tratam do corpo e do banquete, Wolfgang Kayser (e sua visão de um grotesco moderno e Victor Hugo. Outros estudos importantes que permeiam esta noção de corpo no poema de Augusto dos Anjos são os de Henri Bergson, Charles Baudelaire e Arthur Schopenhauer.

  9. O desejo de ter um filho…: as vivências do casal infértil

    OpenAIRE

    Delgado, Maria João Coito

    2007-01-01

    Dissertação de Mestrado em Comunicação em Saúde apresentada à Universidade Aberta Um casal é considerado infértil quando não ocorre uma gravidez, após um ano de relações sexuais regulares não protegidas. A infertilidade tem vindo a ser descrita como uma crise importante que comporta uma dimensão física, psíquica, emocional e socio-cultural. O presente estudo, exploratório, de tipo descritivo, tem como objectivo central, conhecer as vivências do casal infértil, que deseja ter filhos. ...

  10. Fitoterápicos: um mercado promissor

    Directory of Open Access Journals (Sweden)

    TRAUDI KLEIN

    2010-06-01

    Full Text Available

    Observa-se na Fitoterapia uma tendência de contribuição efetiva à saúde da população. Por consequência, a padronização de fitomedicamentos é um pré-requisito para a garantia da qualidade, bem como para a constância dos efeitos terapêuticos e segurança do usuário. A validação de processo analítico deve garantir, através de evidências experimentais, que o método atenda às exigências das aplicações analíticas, assegurando a confiabilidade dos resultados. Assim, os equipamentos e materiais de laboratório devem ser devidamente calibrados e o analista qualificado. As substâncias químicas de referência devem ser certificadas por compêndios oficiais, como as Farmacopeias ou por outros códigos autorizados pela legislação vigente.Tão importante quanto o desenvolvimento e validação de uma metodologia analítica é o posterior estudo de estabilidade, a fim de garantir que o produto mantenha sua qualidade durante toda vida útil. Para a obtenção de registro de um medicamento fitoterápico dentro dos padrões requeridos pela legislação faz-se necessário, portanto, a realização de diferentes testes para validação deste medicamento de forma a garantir sua segurança no uso, eficácia na utilização e qualidade do produto. Palavras-chave: Fitomedicamentos. Validação. Saúde Publica. Padronização. ABSTRACT Phytomedicines: a promising market There is an observable trend towards phytotherapy making a recognized effective contribution to public health. Consequently, the standardization of phytomedicines is a prerequisite for quality assurance and to ensure the consistency of therapeutic effects and safety of the user. Analytical method validation should ensure, through experimental testing, that the method meets the requirements of the analytical applications, ensuring the reliability of results. Thus, the equipment and laboratory materials must be properly calibrated and the analyst

  11. Intramuscular tendon involvement on MRI has limited value for predicting time to return to play following acute hamstring injury

    NARCIS (Netherlands)

    van der Made, Anne D.; Almusa, Emad; Whiteley, Rod; Hamilton, Bruce; Eirale, Cristiano; van Hellemondt, Frank; Tol, Johannes L.

    2018-01-01

    Background Hamstring injury with intramuscular tendon involvement is regarded as a serious injury with a delay in return to play (RTP) of more than 50 days and reinjury rates up to 63%. However, this reputation is based on retrospective case series with high risk of bias. Objective Determine whether

  12. Salivary testosterone in female-to-male transgender adolescents during treatment with intra-muscular injectable testosterone esters

    NARCIS (Netherlands)

    Bui, Hong N.; Schagen, Sebastian E. E.; Klink, Daniel T.; Delemarre-van de Waal, Henriette A.; Blankenstein, Marinus A.; Heijboer, Annemieke C.

    2013-01-01

    In our hospital, female-to-male (FtM) transgender adolescents from the age of 16 are treated with two- or four-weekly intra-muscular injections of testosterone-esters. Some patients treated with four-weekly injections have complaints of fatigue and experience mood swings towards the end of the

  13. Intramuscular migration of calcific tendinopathy in the rotator cuff: ultrasound appearance and a review of the literature.

    Science.gov (United States)

    Becciolini, Marco; Bonacchi, Giovanni; Galletti, Stefano

    2016-09-01

    Calcific tendinopathy of the shoulder is a common condition caused by calcium hydroxyapatite crystals, affecting the tendons of the rotator cuff. Among uncommon complication, one is the migration of the calcium in the subacromion-subdeltoid bursa. More rare is the intraosseous migration. We present four cases of an even more rare condition, not well described in literature yet, the intramuscular migration of calcium.

  14. Salivary testosterone in female-to-male transgender adolescents during treatment with intra-muscular injectable testosterone esters

    NARCIS (Netherlands)

    Bui, H.N.; Schagen, S.E.; Klink, D.T.; Delemarre-van de Waal, H.A.; Blankenstein, M.A.; Heijboer, A.C.

    2013-01-01

    Introduction: In our hospital, female-To-male (FtM) transgender adolescents from the age of 16 are treated with two- or four-weekly intra-muscular injections of testosterone-esters. Some patients treated with four-weekly injections have complaints of fatigue and experience mood swings towards the

  15. Immunogenicity and safety of low dose virosomal adjuvanted influenza vaccine administered intradermally compared to intramuscular full dose administration

    NARCIS (Netherlands)

    Künzi, Valérie; Klap, Jaco M.; Seiberling, Michael K.; Herzog, Christian; Hartmann, Katharina; Kürsteiner, Oliver; Kompier, Ronald; Grimaldi, Roberto; Goudsmit, Jaap

    2009-01-01

    BACKGROUND: Despite the established benefit of intramuscular (i.m.) influenza vaccination, new adjuvants and delivery methods for comparable or improved immunogenicity are being explored. Intradermal (i.d.) antigen administration is hypothesized to initiate an efficient immune response at reduced

  16. 18F-FDG PET/CT Findings Following Repeated Intramuscular Injections of "Site Enhancement Oil" in the Upper Extremities

    DEFF Research Database (Denmark)

    Dejanović, Danijela; Loft, Annika

    2017-01-01

    We present the findings on F-FDG PET/CT in a 50-year-old man known to self-administer intramuscular injections with site enhancement oil in the upper extremities. PET images show diffuse pathological high FDG uptake in soft tissue of the upper arms and in scanned portions of the forearms. On the CT...

  17. The Effect of the Timing of Intramuscular Oxytocin Injection on Maternal Bleeding during the Third Stage of Labour

    Directory of Open Access Journals (Sweden)

    Sakine Mohamadian

    2013-12-01

    Full Text Available Background and aim: The third stage of labour is one of the most troublesome stages of child delivery. The basic principle of the third stage management is administrating prophylactic uterotonics. However, the time of its administration varies in different hospitals. This study aimed to determine the effect of intramuscular oxytocin injection after emergence of the fetal anterior shoulder or placental expulsion on bleeding in the third stage of labour. Methodology: This clinical trial was conducted on 100 pregnant women with gestational age of 38-42 weeks, and singleton pregnancies. Subjects were selected using convenience sampling and were then randomly assigned to intervention (injection of 10 IU intramuscular oxytocin after emergence of the fetal anterior shoulder and control (injection of 10 IU intramuscular oxytocin after placental expulsion groups. Blood was collected in containers and weighed with a weighing scale.  A checklist was used to record labor and delivery related data. Data were analyzed by SPSS version 11.5, using Chi-square and t-test. Findings: The mean amount of bleeding during the third stage of labour was 183.4 ± 145.8 and 202.2 ±208.8 ml in intervention and control group, respectively. No significant difference was found between two groups in terms of maternal bleeding. Conclusion: Injection of intramuscular oxytocin either after emergence of the fetal anterior shoulder or placental expulsion does not affect the amount of maternal bleeding during the third stage of labour.

  18. Intramuscular Perfusion Response in Delayed Onset Muscle Soreness (DOMS): A Quantitative Analysis with Contrast-Enhanced Ultrasound (CEUS).

    Science.gov (United States)

    Kellermann, Marion; Heiss, Rafael; Swoboda, Bernd; Gelse, Kolja; Freiwald, Jürgen; Grim, Casper; Nagel, Armin; Uder, Michael; Wildner, Dane; Hotfiel, Thilo

    2017-10-01

    The purpose of this study was to analyse intramuscular perfusion response in ultrastructural muscle lesions, by applying contrast-enhanced ultrasound (CEUS) to a delayed onset muscle soreness (DOMS) model. Results of this analysis were compared to high-resolution 3 Tesla MRI T2-weighted sequences. 14 healthy participants were recruited. Average perfusion parameters, represented as Peak enhancement (contrast agent inflow) and wash-in area under curve (WiAUC) of the gastrocnemius (GM) and soleus muscle (SM) were assessed before (baseline) and 60 h after inducing DOMS by eccentric exercise. Additionally, conventional ultrasound, high-resolution 3T MRI, creatine kinase level, range of motion (ROM) of the ankle joint, calf circumference and muscle soreness data were collected. Perfusion quantification revealed a statistically significant increase of intramuscular perfusion, corresponding to an increase in peak enhancement of 129.6% (p=0.0031) and in WiAUC of 115.2% (p=0.0107) in the gastrocnemius muscle at post-intervention. At follow-up, the MRI investigations showed intramuscular oedema for GM in all participants corresponding to a significant rise in T2 signal intensity (p=0.001) and in T2 time value (p=0.005). CEUS seems to be able to detect intramuscular perfusion changes and therefore may contribute to gaining deeper insight into the histopathology, inflammatory reactions and regeneration processes of ultrastructural muscle lesions. © Georg Thieme Verlag KG Stuttgart · New York.

  19. No protection in chickens immunized by the oral or intra-muscular immunization route with Ascaridia galli soluble antigen

    DEFF Research Database (Denmark)

    Andersen, Janne Pleidrup; Norup, Liselotte R.; Dalgaard, Tina S.

    2013-01-01

    of this study was to evaluate the induction of protective immune responses to A. galli soluble antigen by different immunization routes. Chickens were immunized with a crude extract of A. galli via an oral or intra-muscular route using cholera toxin B subunit as adjuvant and subsequently challenged with A...

  20. Qualidade total: Um novo paradigma?

    Directory of Open Access Journals (Sweden)

    Suzana da Rosa Tolfo

    1999-01-01

    Full Text Available Nos últimos anos, o movimento para a implantação da Gestão da Qualidade Total vem crescendo ao redor do mundo. Em razão disso, há uma diversidade de ações realizadas com o nome de "Qualidade Total'. Uma revisão da teoria é complexa, porque existem muitos autores que tratam da questão. Eles escolhem diferentes perspectivas de análises (teóricas e empíricas e há dificuldades em se identificar um corpo conceitual. Há uma ampla difusão de modelos, ferramentas, técnicas, mercado e consultores. Essa popularidade, muitas vezes, faz com que determinadas organizações adotem essa forma de gestão do trabalho sem o conhecimento necessário das implicações que um modelo dessa ordem representa; especialmente no caso brasileiro, suscetível a proposições importadas. O presente artigo propõe um exame daquilo que os fundadores têm articulado sobre TQM, as principais críticas nesta direção e a avaliação de como vem sendo aplicadono nosso país.

  1. Tradução e Validação da Escala FOUR para a Pediatria e o seu Uso Como Indicador Prognóstico: Um Estudo Piloto

    Directory of Open Access Journals (Sweden)

    Sofia Simões Ferreira

    2017-09-01

    Conclusão: A escala FOUR pode ser aplicada nos doentes internados com depressão do estado de consciência na unidade de cuidados intensivos pediátricos. Consideramos que um estudo multicêntrico seria importante para confirmar estes resultados.

  2. Tecnologia, especialização regional e produtividade: um estudo da pecuária leiteira em Minas Gerais

    Directory of Open Access Journals (Sweden)

    Mauro Borges Lemos

    2003-01-01

    Full Text Available Este trabalho pretende estabelecer um comparativo entre algumas microrregiões mineiras produtoras de leite, enfocando, sobretudo, características tecnológicas e de especialização. Trabalha-se com a idéia de que estas variáveis explicam em grande medida o diferencial de produção e produtividade do setor leiteiro, sendo importante o seu entendimento dentro do contexto de intensas mudanças as quais o setor vem passando nos últimos anos no Brasil. Desenvolvendo um estudo de dimensão espacial, pretende-se traçar um perfil da atividade em Minas Gerais, apontando os principais "gargalos" para o seu desenvolvimento e as perspectivas para a redução das desigualdades no setor.

  3. Desenvolvimento de um método potenciométrico para deteção de salmonella typhimurium

    OpenAIRE

    Silva, Nádia Filipa Durão da

    2013-01-01

    A Salmonella é um microrganismo responsável por grande parte das doenças alimentares, podendo por em causa a saúde pública da área contaminada. Uma deteção rápida, eficiente e altamente sensível e extremamente importante, sendo um campo em franco desenvolvimento e alvo de variados e múltiplos estudos na comunidade cientifica atual. Foi desenvolvido um método potenciométrico para a deteção de Salmonellas, com elétrodos seletivos de iões, construídos em laboratório com pontas de micropipetas...

  4. COMPARISON OF INTRAMUSCULAR FAT CONTENT IN THE FIRST FARROWING GILTS AND IN THE FATTENING GILTS

    Directory of Open Access Journals (Sweden)

    ALEKSANDRA JELIŃSKA

    2010-02-01

    Full Text Available The aim of the study was to compare the slaughter value and meat quality of the first farrowing gilts with normal fattening gilts. The study was carried out on 30 primiparous gilts (A and 39 fattening gilts (B. Age of A gilts at slaughter was 371.03 days and that of B gilts was two times lower and attained 179.64 days. However carcass fatness of the younger B gilts was higher than of primiparous gilts (P < 0.05 and carcass lean content was high in both gilt groups. Meat characteristics were determined in longissimus lumborum muscle. Some differences between the compared gilt groups were stated in muscle colour, WHC, protein and intramuscular fat content. Higher IMF content was found in primiparous gilts (1.88 ± 0.50 versus 1.19 ± 0.39%; P< 0.01.

  5. Intramuscular fatty acid metabolism in contracting and non-contracting human skeletal muscle

    DEFF Research Database (Denmark)

    Sacchetti, M; Saltin, B; Osada, T

    2002-01-01

    The present study was undertaken to investigate the fate of blood-borne non-esterified fatty acids (NEFA) entering contracting and non-contracting knee extensor muscles of healthy young individuals. [U-(13)C]-palmitate was infused into a forearm vein during 5 h of one-legged knee extensor exercise...... at 40 % of maximal work capacity and the NEFA kinetics, oxidation and rate of incorporation into intramuscular triacylglycerol (mTAG) were determined for the exercising and the non-exercising legs. During 4 h of one-legged knee extensor exercise, mTAG content decreased by 30 % (P ....05) in the contracting muscle, whereas it was unchanged in the non-contracting muscle. The uptake of plasma NEFA, as well as the proportion directed towards oxidation, was higher in the exercising compared to the non-exercising leg, whereas the rate of palmitate incorporation into mTAG was fourfold lower (0.70 +/- 0...

  6. MEDIDA DAS CAPACIDADES PSICOMOTORAS ENVOLVIDAS NA TÉCNICA DA INJEÇÃO INTRAMUSCULAR

    Directory of Open Access Journals (Sweden)

    Ana Maria Kazue Miyadahira

    Full Text Available Partindo-se do pressuposto de que no estudo de habilidades psicomotoras, a medida das capacidades motoras é fundamental, apresenta-se dois testes passíveis de serem utilizados pela enfermagem. Estes testes, denominados "psicomotor eletrônico" e "perfuragem" foram aplicados na primeira etapa do estudo sobre o processo de ensino-aprendizagem de habilidades psicomotoras no qual analisou-se a técnica de injeção intramuscular. Três grupos de estudantes de graduação em enfermagem, em diferentes estágios de desenvolvimento no curso, foram avaliados e verificou-se que eles eram homogêneos em relação às capacidades psicomotoras testadas.

  7. Decrease in intramuscular lipid droplets and translocation of HSL in response to muscle contraction and epinephrine

    DEFF Research Database (Denmark)

    Prats, Clara; Donsmark, Morten; Qvortrup, Klaus

    2006-01-01

    stimulation or muscle contraction on skeletal muscle TG content and HSL intracellular distribution. Rat soleus muscles were either incubated with epinephrine or electrically stimulated for 15 min. Single muscle fibers were used for morphological analysis by confocal and transmission electron microscopy. We......A better understanding of skeletal muscle lipid metabolism is needed to identify the molecular mechanisms relating intramuscular triglyceride (IMTG) to muscle metabolism and insulin sensitivity. An increasing number of proteins have been reported to be associated with intracellular triglyceride (TG......), among them the PAT family members: perilipin, ADRP (for adipocyte differentiation-related protein), and TIP47 (for tail-interacting protein of 47 kDa). Hormone-sensitive lipase (HSL) is thought to be the major enzyme responsible for IMTG hydrolysis in skeletal muscle. In adipocytes, regulation of HSL...

  8. Pharmacokinetic-Pharmacodynamic Model To Evaluate Intramuscular Tetracycline Treatment Protocols To Prevent Antimicrobial Resistance in Pigs

    DEFF Research Database (Denmark)

    Ahmad, Amais; Græsbøll, Kaare; Christiansen, Lasse Engbo

    2015-01-01

    to which resistant strains outcompete susceptible strains under antimicrobial pressure may depend not only on the antimicrobial treatment strategies but also on the epidemiological parameters, such as the composition of the bacterial strains in a pig. This study evaluated how variation in the dosing......High instances of antimicrobial resistance are linked to both routine and excessive antimicrobial use, but excessive or inappropriate use represents an unnecessary risk. The competitive growth advantages of resistant bacteria may be amplified by the strain dynamics; in particular, the extent...... protocol for intramuscular administration of tetracycline and the composition of bacterial strains in a pig affect the level of resistance in the intestine of a pig. Predictions were generated by a mathematical model of competitive growth of Escherichia coli strains in pigs under specified plasma...

  9. Pharmacokinetics of a florfenicol-tylosin combination after intravenous and intramuscular administration to beagle dogs.

    Science.gov (United States)

    Kim, Eun-Young; Gebru, Elias; Lee, Joong-Su; Kim, Jong-Choon; Park, Seung-Chun

    2011-04-01

    A pharmacokinetic study of a commercial florfenicol-tylosin (2:1) combination product was conducted in six beagle dogs after intravenous (IV) and intramuscular (IM) administration at doses of 10 mg/kg (florfenicol) and 5 mg/kg (tylosin). Serum drug concentrations were determined by a validated high performance liquid chromatography (HPLC) using UV detection. A rapid and nearly complete absorption of both drugs with a mean IM bioavailability of 103.9% (florfenicol) and 92.6% (tylosin), prolonged elimination half-life, and high tissue penetration with steady state volume of distribution of 2.63 l/kg (florfenicol) and 1.98 l/kg (tylosin) were observed. Additional studies, including pharmacodynamic and toxicological evaluation are required before recommendations can be made regarding the clinical application of the product in dogs.

  10. Intramuscular atropine in elderly people: Pharmacokinetic studies using the radioreceptor assay and some pharmacodynamic responses

    International Nuclear Information System (INIS)

    Kentala, E.; Kaila, T.; Kanto, J.

    1989-01-01

    The pharmacokinetics (radioreceptor assay, RRA) and som clinical effects of atropine were studied in 7 elderly gynaecological surgery patients. The RRA measures only the pharmacologically active isomer of atropine, 1-hyoscyamine. Following a single 0.01 mg/kg intramuscular (M. deltoideus) injection, a very fast rate of absorption was found with mean peak serum concentration occurring after only 13 min. The reason for this could be either a preferential tissue uptake of the 1-form or the injection site or both. The elimination half-life was 2.27 hr. Only 23.1% of the given drug was excreted in urine in 24 hr as a pharmacologically active form. The clinical effects (heart rate rise, subjective sedation and antisialogogue effect) were seen after only 30 min. This somewhat faster appearance of clinical effects than in previous studies can be due to the injection site. The sedative effect of the drug is clear and long lasting in elderly people. (author)

  11. Comparison between intravenous and intramuscular administration of ketamine in children sedation referred to emergency department

    Directory of Open Access Journals (Sweden)

    Behnaz Boroumand Rezazadeh

    2014-12-01

    Full Text Available Ketamine, among wide variety of sedative drugs, has shown beneficial effects when using during the procedural sedation, specifically in pediatrics. Various parameters should be considered in order to perform a safe and effective procedural sedation including optimum dosage of the sedative, administration methods of sedation, and need for applying any adjuvant drug. In this study, we aimed to review the studies, which have compared the efficacy of the different ways of the injection of ketamine such as intravenous or intramuscular ketamine application. Based on data obtained from the related articles, efficacy and safety of these two methods of ketamine usage in the pediatric procedural sedation were widely similar, but the intravenously administration of the ketamine can be proposed as the preferable mode.

  12. O INSTITUTO DO INQUÉRITO CIVIL VISTO COMO FORMA E MEIO IMPORTANTE PARA PACIFICAR AS DEMANDAS COLETIVAS E A DISCUSSÃO DE SEU DEVIDO PROCESSO CONSTITUCIONAL

    Directory of Open Access Journals (Sweden)

    Francisco das Chagas da Silva

    2017-06-01

    Full Text Available O objetivo deste trabalho é abordar as peculiaridades do inquérito civil no direito brasileiro sob a ótica dos princípios que embasam o devido processo legal. Introduzido pela lei da Ação Civil Pública, o Inquérito Civil é um instituto de titularidade do Ministério Público voltado a auxiliar a pacificação dos conflitos coletivos, servindo de fundamento para a propositura de ações coletivas e de firmação do termo de ajustamento de conduta (TAC, mecanismos processuais e extraprocessuais que tem como finalidade a defesa de interesses difusos, coletivos e individuais homogêneos. Durante todo o desenvolvimento desta pesquisa foram analisadas diversas obras literárias dos mais variados autores da área do direito processual civil, do direito processual do trabalho e do direito constitucional, além da apreciação de dados oriundos da jurisprudência pátria, bem como revistas e periódicos da área jurídica pertinentes ao tema aqui desenvolvido. O trabalho está dividido numa apreciação sobre o devido processo constitucional e nos princípios norteadores do processo. Depois será desenvolvida uma análise acerca da natureza jurídica do inquérito civil e, por fim, uma discussão acerca do contraditório nesse procedimento administrativo, verificando as argumentações doutrinárias que negam a aplicação deste princípio.

  13. Infecções de repetição: o que é importante para o pediatra Recurrent infections: what is important to pediatricians

    Directory of Open Access Journals (Sweden)

    Pérsio Roxo Júnior

    2009-12-01

    Full Text Available OBJETIVO: Apresentar uma revisão atualizada sobre infecções de repetição em crianças, abordando importantes aspectos para o pediatra relacionados a infecções em crianças saudáveis e em crianças com imunodeficiências primárias. FONTES DE DADOS: Artigos relacionados ao tema foram coletados dos bancos de dados Medline e Lilacs no período entre 1980 e 2008, tendo sido selecionados artigos de meta-análise, revisão e estudos clínicos realizados em seres humanos, cuja metodologia e discussão estavam bem estruturadas. Também foram incluídos livros-texto nacionais e internacionais pertinentes ao tema. SÍNTESE DOS DADOS: Infecções de repetição são frequentes na clínica pediátrica. Aproximadamente 50% dessas crianças são saudáveis e 10% podem ser imunodeficientes. A criança saudável apresenta crescimento e desenvolvimento normais e se encontra bem entre os episódios infecciosos. As infecções, na maioria das vezes, não têm curso prolongado ou complicado e ocorrem devido ao aumento da exposição a agentes infecciosos do meio ambiente nos primeiros anos de vida. As imunodeficiências primárias geralmente se manifestam como infecções de repetição por microorganismos específicos ou por germes de baixa virulência. Na maioria das vezes, os quadros infecciosos apresentam evolução prolongada, resposta inadequada à antibioticoterapia e elevados riscos de complicações. CONCLUSÕES: O diagnóstico precoce das imunodeficiências primárias é essencial para que medidas terapêuticas sejam rapidamente instituídas, reduzindo os riscos de ocorrência de óbito e complicações.OBJECTIVE: To present an up-to-date review about recurrent infections in children, addressing important aspects for pediatricians related to infections in healthy children and in children with primary immunodeficiencies. DATA SOURCE: Articles related to the subject were collected from Medline and Lilacs databases between 1980 and 2008, selecting

  14. CLINICALLY IMPORTANT FORMATIONS ON THE INTERIOR SURFACE OF THE BRACHIOCEPHALIC TRUNK. Formaciones clinicamente importantes en la superficie interna del tronco braquiocefálico

    Directory of Open Access Journals (Sweden)

    Susana N Biasutto

    2016-03-01

    Full Text Available Las características de la división arterial representan un factor de riesgo para la oclusión arterial y causa frecuente de dificultad para la cateterización. Su forma de presentación depende de la unión del 3º y 4º arcos aórticos. Con el objetivo de evidenciar las caracterís-ticas del tronco braquiocefálico (TBC se estudiaron 40 fetos de entre 12 y 23 semanas de gestación. Se disecaron los grandes vasos y el TBC fue seccionado en su origen y resecado conjuntamente con la porción proximal de las arterias carótida común derecha (CCD y subclavia derecha (SD. Se midió la longitud, el ancho y los ángulos interno y geométrico entre las arterias CCD y SD. Abrimos las arterias para observar la luz vascular. Se documentó fotográficamente. La longitud promedio fue de 4,25 mm y el ancho promedio de 1,53 mm. No se evidenció relación directa entre las medidas de los TBC y la edad fetal. La mediana del ángulo interno fue de 62º. Sólo el 50% de los TBC pudieron ser abiertos, permitiendo observar la presencia de tabiques parciales entre ambos vasos en el 20% de los casos y de espolones a nivel de la bifurcación en otro 10%. No hallamos descripciones sobre estos relieves en la literatura. El ángulo interno entre ambas arterias fue significativa-mente mayor en los casos que presentaron relieves. En conclusión, la presencia de relieves en la superficie interna del TBC tiene origen embriológico y representaría un factor importante de riesgo para patología obstructiva vascular y causa de dificultad para la cateterización. Arterial division features constitute risk factors for arterial occlusion and frequently cause difficulties in catheterization. In this case the relevant feature is the junction of the 3rd and 4th aortic arches. With the aim of displaying the features of the brachiocephalic trunk (BCT, we studied 40 fetuses of between 12 and 23 weeks of gestation. Great vessels were dissected and the BCT was cut and resected at its

  15. Efficacy and safety of intramuscular midazolam versus rectal diazepam in controlling status epilepticus in children.

    Science.gov (United States)

    Momen, Ali Akbar; Azizi Malamiri, Reza; Nikkhah, Ali; Jafari, Maryam; Fayezi, Abbas; Riahi, Kourosh; Maraghi, Elham

    2015-03-01

    The aim of this study was to evaluate the efficacy and safety of intramuscular midazolam in controlling convulsive status epilepticus in children, by comparing it with rectal diazepam. In this randomized trial, 100 children (50 in each group) with convulsive status epilepticus aged 1 month to 16 years were enrolled and randomly assigned into two groups to receive either 0.3 mg/kg intramuscular midazolam or 0.5 mg/kg rectal diazepam. Main outcome measure was stopping of all motor activity after drug administration. Another measures were times between patient's arrival to emergency department till drug administration, between drug administration to seizure cessation, and between patient's arrival to seizure cessation. Both medication were effective for seizure control and no significant difference was found between successful treatments after administering the medication (P = 0.061). In the midazolam group, in 96% (48/50) of cases treatment was successful and in the diazepam group, in 94% (47/50) of cases treatment was successful. Time from arrival to administering the medication was significantly shorter in midazolam group (P = 0.017). The majority of seizures in midazolam group were stopped in less than 66 s (median) compared to 130 s (median) for diazepam group, (P diazepam for controlling of status epilepticus in children. Midazolam via IM route could be one of the choices in children with convulsive status seizures who have difficult IV access. Copyright © 2014 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

  16. Comparison of artemisinin suppositories, intramuscular artesunate and intravenous quinine for the treatment of severe childhood malaria.

    Science.gov (United States)

    Cao, X T; Bethell, D B; Pham, T P; Ta, T T; Tran, T N; Nguyen, T T; Pham, T T; Nguyen, T T; Day, N P; White, N J

    1997-01-01

    Severe malaria remains a major cause of mortality and morbidity for children living in many tropical regions. With the emergence of strains of Plasmodium falciparum resistant to both chloroquine and quinine, alternative antimalarial agents are required. The artemisinin group of compounds are rapidly effective in severe disease when given by intramuscular or intravenous injection. However, these routes of administration are not always available in rural areas. In an open, randomized comparison 109 Vietnamese children, aged between 3 months and 14 years, with severe P.falciparum malaria, were allocated at random to receive artemisinin suppositories followed by mefloquine (n = 37), intramuscular artesunate followed by mefloquine (n = 37), or intravenous quinine followed by pyrimethamine/sulfadoxine (n = 35). There were 9 deaths: 2 artemisinin, 4 artesunate and 5 quinine-treated children. There was no difference in fever clearance time, coma recovery, or length of hospital stay among the 3 groups. However, parasite clearance times were significantly faster in artemisinin and artesunate-treated patients than in those who received quinine (P children receiving these drugs had lower peripheral reticulocyte counts by day 5 of treatment than those in the quinine group (P = 0.011). No other adverse effect or toxicity was found. There was no treatment failure in these 2 groups, but 4 patients in the quinine group failed to clear their parasites within 7 d of starting treatment and required alternative antimalarial therapy. Artemisinin suppositories are easy to administer, cheap, and very effective for treating children with severe malaria. In rural areas where medical facilities are lacking these drugs will allow antimalarial therapy to be instituted earlier in the course of the disease and may therefore save lives.

  17. In-vitro and in-vivo evaluation of diclofenac sodium intramuscular injection using gamma scintigraphy

    International Nuclear Information System (INIS)

    Soni, S.; Kumar, N.; Mehra, L.; Singh, T.; Mittal, G.; Nishad, D.K.; Sharma, B.G.; Bhatnagar, A.

    2010-01-01

    Full text: Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) which is available as over-the-counter (OTC) medication for the systemic and topical treatment of painful and inflammatory conditions such as arthritis and back pain. This study was undertaken to investigate the distribution and retention of intramuscularly injected diclofenac sodium (DFN) in white New Zealand rabbit using gamma scintigraphy. A new formulation of the nonselective NSAID diclofenac sodium suitable for intramuscular injection has been developed using sesame oil as a vehicle. The hypothesis of present work is to maintain effective concentration of DFN in blood for prolonged time period. A novel method of radiolabeling with 99m Tc-pertechnetate was adopted using stannous ions as reducing agent. The radiolabeled product was tested for quality control using ascending instant thin layer chromatography (ITLC) technique. ITLC-SG, (Gelman, USA) and acetone were used as the stationary phase and mobile phase respectively in the chromatographic procedure. In vitro and in vivo stability parameters were evaluated. Biodistribution studies and blood kinetics of 99m Tc-DFN was done in balb c mice and white New Zealand rabbit respectively. 99m Tc-DFN retention at depot site was evaluated using gamma scintigraphy. 99m Tc-DFN, when incubated at 37 deg C for 24 hr in normal saline and human serum showed disintegration of only 6.6% and 3.5% respectively, thereby indicating high stability of radiolabeled product. Protein binding studies of 99m Tc-DFN shows more than 85% serum protein binding. Blood clearance of radiopharmaceutical in rabbits, exhibited a biphasic exponential pattern in i.v. bolus while in i.m. linear control release pattern were observed up to 24 hrs

  18. Population pharmacokinetic and pharmacodynamic properties of intramuscular quinine in Tanzanian children with severe Falciparum malaria.

    Science.gov (United States)

    Hendriksen, Ilse C E; Maiga, Deogratius; Lemnge, Martha M; Mtove, George; Gesase, Samwel; Reyburn, Hugh; Lindegardh, Niklas; Day, Nicholas P J; von Seidlein, Lorenz; Dondorp, Arjen M; Tarning, Joel; White, Nicholas J

    2013-02-01

    Although artesunate is clearly superior, parenteral quinine is still used widely for the treatment of severe malaria. A loading-dose regimen has been recommended for 30 years but is still often not used. A population pharmacokinetic study was conducted with 75 Tanzanian children aged 4 months to 8 years with severe malaria who received quinine intramuscularly; 69 patients received a loading dose of 20 mg quinine dihydrochloride (salt)/kg of body weight. Twenty-one patients had plasma quinine concentrations detectable at baseline. A zero-order absorption model with one-compartment disposition pharmacokinetics described the data adequately. Body weight was the only significant covariate and was implemented as an allometric function on clearance and volume parameters. Population pharmacokinetic parameter estimates (and percent relative standard errors [%RSE]) of elimination clearance, central volume of distribution, and duration of zero-order absorption were 0.977 liters/h (6.50%), 16.7 liters (6.39%), and 1.42 h (21.5%), respectively, for a typical patient weighing 11 kg. Quinine exposure was reduced at lower body weights after standard weight-based dosing; there was 18% less exposure over 24 h in patients weighing 5 kg than in those weighing 25 kg. Maximum plasma concentrations after the loading dose were unaffected by body weight. There was no evidence of dose-related drug toxicity with the loading dosing regimen. Intramuscular quinine is rapidly and reliably absorbed in children with severe falciparum malaria. Based on these pharmacokinetic data, a loading dose of 20 mg salt/kg is recommended, provided that no loading dose was administered within 24 h and no routine dose was administered within 12 h of admission. (This study has been registered with Current Controlled Trials under registration number ISRCTN 50258054.).

  19. Can Preoperative Intramuscular Single-Dose Dexamethasone Improve Patient-Centered Outcomes Following Third Molar Surgery?

    Science.gov (United States)

    Al-Dajani, Mahmoud

    2017-08-01

    Because of increased attention focused on administering dexamethasone to treat third molar surgical complications, this study investigated the efficacy of single-dose dexamethasone in managing postoperative complications after impacted third molar surgery. Pain intensity and analgesic intake, patients' discomfort, limitation of oral function, and limitation of daily activities were assessed. This triple-blinded split-mouth randomized controlled clinical trial included patients 18 to 30 years old who underwent randomized bilateral extractions of impacted mandibular third molars during 2 consecutive sessions. Each patient was given a single-dose intramuscular injection of dexamethasone (0.1 mg/kg) preoperatively in 1 session and a placebo in the other session. Data were collected daily for 7 postoperative days, and 14 patient-centered outcomes were interpreted. A 2-tailed P value less than .05 was considered significant. All 32 patients (100%) enrolled completed the study. When administered dexamethasone, patients reported less pain (P ≤ .007), took fewer analgesics (P ≤ .002), reported less swelling (P ≤ .007), had less difficulty in eating (P ≤ .024), had less difficulty in enjoying food (P ≤ .005), had less difficulty in speech (P = .043), had less trismus (P = .005), were absent less from school or work (P ≤ .016), and had less disruption of daily activity (P ≤ .042). The differences between the 2 conditions in bleeding, malaise, and sleep disturbance were not significant (P > .05). Prophylactic dexamethasone administered intramuscularly before third molar surgery should be recommended as a safe and effective strategy for decreasing pain and discomfort and enhancing oral functions and daily activities, unless contraindicated. Copyright © 2017 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

  20. Anatomic localization of motor entry points and intramuscular nerve endings in the hamstring muscles.

    Science.gov (United States)

    An, X C; Lee, J H; Im, S; Lee, M S; Hwang, K; Kim, H W; Han, Seung-Ho

    2010-07-01

    To elucidate the location of motor entry points (MEPs) and intramuscular nerve endings of the hamstring muscles. We dissected 50 cadaveric lower extremities to identify the MEPs, where the nerve branch first pierced the muscle belly, and the proximal and distal limit points (PLPs and DLPs, respectively) of the terminal intramuscular nerve endings. These points were measured in relation to a reference line, expressed in x-coordinate, which connected the superior medial aspect of ischial tuberosity to the proximal aspect of the medial femoral epicondyle. We also expressed the MEP in y-coordinate, which is perpendicular to the x-coordinate connecting the superior medial aspect of ischial tuberosity to the lateral aspect of the greater trochanter. Finally, these distances were translated into percentage distances in relation to the total length of the reference lines and their mean values were calculated. For the long head of biceps femoris muscles, the MEPs were located at 41.5 and 36.3% distance of the x and y coordinates, while the PLP and DLP were located at 39.7 and 72.9% distance of the x-coordinate. For the short head, the corresponding data were 56.2, 59.7, 58.9 and 80.2%. The semitendinosus showed two innervations zones; the data for the upper and lower zones were 20.3, 18.9, 18.6, 36.8% and 59.9, 21.4, 56.6, 79.1%, respectively. For the semimembranosus, the data were 62.2, 18.8, 55.9 and 89.1%. The parameters provided from this study should help increase the efficacy and precision of motor point injections to the hamstring muscles.

  1. Intramuscular oxygen-ozone therapy in the treatment of low back pain.

    Science.gov (United States)

    Biazzo, Alessio; Corriero, Andrea Saverio; Confalonieri, Norberto

    2018-03-27

    Intramuscular paravertebral injections of ozone are minimally invasive, safe and efficacy in reducing pain and disability. The aim of this paper is to present the early results of paravertebral lumbar ozone injections in the treatment of low back pain. Between February 2011 and December 2015, a total of 109 patients underwent intramuscular paravertebral lumbar injections of ozone due to low back pain. Of them, 42 interrupted the treatment at a medium of 5.4 injections and were lost to follow-up. Of the 67 remaining patients, only 24 answered to our questionnaire. Local and radiating pain was assessed using a 10-cm horizontal Visual Analogue Scale. Perceived functional status and disability were evaluated using the Oswestry Disability Index, administered before treatment and one month after the last injection. Visual Analogue Scale reduction was demonstrated in 23 out of 29 cycles (79%) of ozone therapy. Regarding disability evaluation, Oswestry Disability Index score reduction was assessed in all except one. No complications were recorded. Our results are similar to the other reports: 79% of patients had VAS reduction of 2.3 points and all except one patient reported ODI reduction (average reduction of 9%). Lumbar paravertebral oxygen-ozone injections are minimally invasive, safe, cheaper and effective in relieving pain as well as disability. This technique is easy to perform, it doesn't need computed-tomography or anesthesiologist support. We suggest its application in low back pain as first choice to replace intradiscal computed-tomography-guided infiltrations and to avoid or delay surgery.

  2. Intramuscular leukemic relapse: clinical signs and imaging findings. A multicentric analysis

    Energy Technology Data Exchange (ETDEWEB)

    Surov, Alexey [Martin Luther University Halle-Wittenberg, Department of Radiology, Halle (Germany); University of Leipzig, Department of Diagnostic and Interventional Radiology, Leipzig (Germany); Kiratli, Hayyam [Hacettepe University School of Medicine, Department of Ophthalmology, Ankara (Turkey); Im, Soo Ah [Seoul St. Mary' s Hospital, Department of Radiology, Seoul (Korea, Republic of); Manabe, Yasuhiro [National Hospital Organization Okayama Medical Center, Department of Neurology, Okayama (Japan); O' Neill, Alibhe; Shinagare, Atul B. [Brigham and Women' s Hospital, Department of Radiology, Boston, MA (United States); Spielmann, Rolf Peter [Martin Luther University Halle-Wittenberg, Department of Radiology, Halle (Germany)

    2014-09-26

    Leukemia is a group of malignant diseases involving peripheral blood and bone marrow. Extramedullary tumor manifestation in leukemia can also occur. They more often involve lymph nodes, skin, and bones. Intramuscular leukemic relapse (ILR) is very unusual. The aim of this analysis was to summarize the reported data regarding clinical signs and radiological features of ILR. The PubMed database was searched for publications related to ILR. After an analysis of all identified articles, 20 publications matched the inclusion criteria. The authors of the 20 publications were contacted and provided imaging of their cases for review. The following were recorded: age, gender, primary diagnosis, clinical signs, pattern, localization and size of the intramuscular leukemic relapse. Images of 16 patients were provided [8 computer tomographic (CT) images and 15 magnetic resonance images, MRI]. Furthermore, one patient with ILR was identified in our institutional database. Therefore, images of 17 patients were available for further analysis. Overall, 32 cases with ILR were included in the analysis. In most cases acute myeloid leukemia was diagnosed. Most ILRs were localized in the extremities (44 %) and in the extraocular muscles (44 %). Clinically, ILR manifested as local pain, swelling and muscle weakness. Radiologically, ILR presented most frequently with diffuse muscle infiltration. On postcontrast CT/MRI, most lesions demonstrated homogeneous enhancement. ILRs were hypo-/isointense on T1w and hyperintense on T2w images. ILR manifests commonly as focal pain, swelling and muscle weakness. ILR predominantly involved the extraocular musculature and the extremities. Radiologically, diffuse muscle infiltration was the most common imaging finding. (orig.)

  3. Field study on the safety and efficacy of intradermal versus intramuscular vaccination against Mycoplasma hyopneumoniae.

    Science.gov (United States)

    Beffort, Lisa; Weiß, Christine; Fiebig, Kerstin; Jolie, Rika; Ritzmann, Mathias; Eddicks, Matthias

    2017-09-30

    The present study compares the safety and efficacy of a needle-free, intradermal Mycoplasma hyopneumoniae vaccine to an intramuscular one. 420 piglets (21+3 days of age) were randomly assigned to two vaccination groups (intradermal vaccination V1 (n=138), intramuscular vaccination V2 (n=144)) and one unvaccinated control group (CG, n=138). As safety parameters clinical observations, local injection site reactions (ISR) and rectal temperatures were assessed. Average daily weight gain (ADWG) and pneumonic lung lesions (LL) were measured as efficacy parameters. ISRs were minor in V1. After both vaccinations, no adverse impact on appetite was observed and mean rectal temperatures remained within physiological range. ADWG during the fattening period was significantly higher in vaccinated groups (V1: 913.4 g, V2: 924.5 g) compared with CG (875.6 g). No differences in ADWG were observed between V1 and V2. Vaccinated pigs had a significantly reduced mean extent of LL compared with CG. V1 was superior in reducing the extent and prevalence of LL compared with V2. These results reveal that a needle-free intradermal vaccination is safe and efficacious in reducing both the prevalence and extent of lung lesions, as well as in improving performance parameters, in a farrow-to-finish farm with a late onset of M hyopneumonia e infection. © British Veterinary Association (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  4. Effectiveness of Per Rectal Misoprostol Versus Intramuscular Oxytocin for Prevention of Primary Postpartum Haemorrhage.

    Science.gov (United States)

    Asmat, Raheela; Ashraf, Tasneem; Asmat, Fazila; Asmat, Shakila; Asmat, Nagina

    2017-01-01

    To compare the effectiveness of per rectal misoprostol over oxytocin in primary postpartum haemorrhage (PPH). Randomised controlled trial study. Gynaecology and Obstetrics Department, Unit IV, Bolan Medical Complex Hospital, Quetta, from September 2013 to February 2014. Emergency obstetric patients receiving per rectal misoprostol (800 µgm) were named as group 'A' and those receiving 10 units oxytocin intramuscularly were labelled as group 'B'. The patients were followed within 24 hours of spontaneous vaginal deliveries. Pads soaked were used to assess the amount of blood loss. A total of 1,678 patients were included in the study. The mean age of patients in group-A was 29.11 years while the mean age of patients in group-B was 29.16 years. One hundred and twenty-three (14.66%) patients in group-A and 120 (14.31%) patients in group-B had PPH. Among the total 1,678 patients, 243 (14.49%) had postpartum haemorrhage among whom 24 (9.88%) had major haemorrhage with a blood loss ≥1000 mL. Among the sub-group (839 patients) administered misoprostol had 123 (14.66%) patients with blood loss greater than 500 mL and the rest 716 patients (85.34%) had blood loss less than 500 mL. The sub-group administered oxytocin have 120 (14.31%) out of 839 patients with postpartum haemorrhage while 719 (85.69%) had blood loss less than 500 mL. Active management of 3rd stage of labour with per rectal misoprostol administration was as effective as intramuscular oxytocin. Both were equally effective to reduce PPH and the subsequent need for surgical interventions.

  5. Capreomycin oleate microparticles for intramuscular administration: Preparation, in vitro release and preliminary in vivo evaluation.

    Science.gov (United States)

    Cambronero-Rojas, Adrián; Torres-Vergara, Pablo; Godoy, Ricardo; von Plessing, Carlos; Sepúlveda, Jacqueline; Gómez-Gaete, Carolina

    2015-07-10

    Capreomycin sulfate (CS) is a second-line drug used for the treatment of multidrug-resistant tuberculosis (MDR-TB). The adverse effects profile and uncomfortable administration scheme of CS has led to the development of formulations based on liposomes and polymeric microparticles. However, as CS is a water-soluble peptide that does not encapsulate properly into hydrophobic particulate matrices, it was necessary to reduce its aqueous solubility by forming the pharmacologically active capreomycin oleate (CO) ion pair. The aim of this research was to develop a new formulation of CO for intramuscular injection, based on biodegradable microparticles that encapsulate CO in order to provide a controlled release of the drug with reduced local and systemic adverse effects. The CO-loaded microparticles prepared by spray drying or solvent emulsion-evaporation were characterized in their morphology, encapsulation efficiency, in vitro/in vivo kinetics and tissue tolerance. Through scanning electron microscopy it was confirmed that the microparticles were monodisperse and spherical, with an optimal size for intramuscular administration. The interaction between CO and the components of the microparticle matrix was confirmed on both formulations by X-ray powder diffraction and differential scanning calorimetry analyses. The encapsulation efficiencies for the spray-dried and emulsion-evaporation microparticles were 92% and 56%, respectively. The in vitro kinetics performed on both formulations demonstrated a controlled and continuous release of CO from the microparticles, which was successfully reproduced on an in vivo rodent model. The results of the histological analysis demonstrated that none of the formulations produced significant tissue damage on the site of injection. Therefore, the results suggest that injectable CO microparticles obtained by spray drying and solvent emulsion-evaporation could represent an interesting therapeutic alternative for the treatment of MDR

  6. Pharmacokinetics and tissue distribution of Antimony after multiple intramuscular administrations in the Hamster

    International Nuclear Information System (INIS)

    Al-Jaser, May H.; Radwan, Mahasen A.; Zaghloul, Imam Y.

    2006-01-01

    The fate of pentavalent antimony (Sb) in different tissues in the body after intramuscular administration is of great interest for the future study of Sb therapy in different sitting. Pharmacokinetics and tissue distribution of antimony (Sb) were studied in the hamster after daily dose of sodium stibogluconate equivalent to 120 mg kg of Sb, administered intramuscularly for two weeks. Liver, spleen, heart, kidney and skin tissues were isolated after blood collection at the specified time. Antimony was measured in these tissues after suitable treatment, ashing and processing, by flame less atomic absorption spectrophotometry. The concentration of Sb time profile in blood showed a linear raid decline with elimination half life (tz1/2) of 1.7h. The concentration of drug (ug/gm) declined in a biphasic manner from almost all tissues. However, the concentrations of Sb were declined in slower fashion from the hamster tissues than from the blood. The maximum concentration of Sb was determined in the kidney tissues (3416+-631ug/gm) while the lowest concentration was in the spleen (209+-187ug/gm). The maximum concentration of Sb in the kidney (ug/gm) was more than 25 fold higher than that measured from blood (ug/ml). The AUC of Sb in the studied tissues was in this rank: kidney>liver>skin>spleen>heart>blood. Surprisingly, the heart, spleen and liver showed a similar t1/2 of 5.2-6.2h while the kidney and skin had a t1/2 of about 3h. Therefore, disposition of Sb seems to kinetically follow multicompartmental compartmental model. The kidneys got the highest concentration of drug which may lead to nephrotoxicity on long term therapy. (author)

  7. MAT2B promotes adipogenesis by modulating SAMe levels and activating AKT/ERK pathway during porcine intramuscular preadipocyte differentiation

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Cunzhen; Chen, Xiaochang; Wu, Wenjing; Wang, Wusu; Pang, Weijun; Yang, Gongshe, E-mail: gsyang999@hotmail.com

    2016-05-15

    Intramuscular fat (IMF) has been demonstrated as one of the crucial factors of livestock meat quality. The MAT2B protein with MAT2α catalyzes the formation of methyl donor S- adenosylmethionine (SAMe) to mediate cell metabolism including proliferation and apoptosis. However, the regulatory effect of MAT2B on IMF deposition is still unclear. In this study, the effect of MAT2B on adipogenesis and its potential mechanism during porcine intramuscular preadipocyte differentiation was studied. The results showed that overexpression of MAT2B promoted adipogenesis and significantly up-regulated the mRNA and protein levels of adipogenic marker genes including FASN, PPARγ and aP2, consistently, knockdown of MAT2B inhibited lipid accumulation and down-regulated the mRNA and protein levels of the above genes. Furthermore, flow cytometry and EdU-labeling assay indicated that MAT2B regulate adipogenesis was partly due to influence intracellular SAMe levels and further affect cell clonal expansion. Also, increased expression of MAT2B activated the phosphorylations of AKT and ERK1/2, whereas knockdown of MAT2B blocked AKT signaling and repressed the phosphorylation of ERK1/2. Moreover, the inhibitory effect of LY294002 (a specific PI3K inhibitor) on the activities of AKT and ERK1/2 was partially recovered by overexpression of MAT2B in porcine intramuscular adipocytes. Finally, Co-IP experiments showed that MAT2B can directly interact with AKT. Taken together, our findings suggested that MAT2B acted as a positive regulator through modifying SAMe levels as well as activating AKT/ERK signaling pathway to promote porcine intramuscular adipocyte differentiation. - Highlights: • MAT2B up-regulates the expression of adipogenic marker genes and promotes porcine intramuscular preadipocyte differentiation. • MAT2B influences intracellular SAMe levels and further affects cell clonal expansion. • MAT2B interacts with AKT and activates AKT/ERK signaling pathway.

  8. Um diálogo entre um cristão ortodoxo e um behaviorista radical

    Directory of Open Access Journals (Sweden)

    Tyffanne Serra Paraná Rodrigues

    Full Text Available Este artigo discute a religião através de um diálogo entre dois sujeitos fictícios: Tommaso, um behaviorista radical e defensor da idéia skinneriana de que a religião não se diferencia de outras formas de controle, e Gottlieb, um cristão ortodoxo e entusiasta da religiosidade. As posições de Tommaso baseiam-se em uma ampla revisão sobre a religião na literatura behaviorista radical, que incluem todos os livros de B. F. Skinner; por sua vez, textos favoráveis à religiosidade, ainda que nem todos mencionem teorias psicológicas, têm Gottlieb como seu porta-voz. Além de se constituir em uma análise conceitual abrangente no interior da literatura behaviorista/skinneriana, este trabalho, favorecendo-se do método dialógico de exposição e, assim, recriando discussões dialéticas nas quais Gottlieb representa o interlocutor oculto nos textos behavioristas, que poderia apresentar argumentos semelhantes aos por ele suscitados, promove novas e distintas reflexões sobre a religiosidade e contribui, portanto, para maior elucidação do tema em questão

  9. Estratégia e ecologia: um estudo de caso

    Directory of Open Access Journals (Sweden)

    Valmir Emil Hoffmann

    1998-12-01

    Full Text Available Com a Revolução Industrial, o uso dos recursos naturais sofreu um grande incremento. Devido sua limitação, a necessidade de lidar com o desenvolvimento e com a preservação do meio ambiente ecológico cria uma das questões mais importantes da atualidade. Assim sendo, a relação entre as empresas e o meio ambiente é o ponto chave para se tentar atenuar o impacto do homem sobre a natureza. O efeito da globalização faz com que a dimensão ecológica, que já possuía interesse global, ganhe força, a ponto das nações mais desenvolvidas encontrarem na defesa da ecologia, uma barreira conveniente aos produtos concorrentes em seus mercados. Dentro desse contexto, as empresas brasileiras buscam alternativas, tanto para atender a intensa fiscalização governamental, dentro do Brasil, como também para continuar participando da competição naqueles mercados mais desenvolvidos, onde as barreiras não tarifárias, de apelo ecológico, bloqueiam o ingresso de seus produtos. O caso da Hering Têxtil, uma das mais importantes industrias têxteis do mundo, é apresentado. A empresa é um referencial relevante dentro dessa discussão. A relação da empresa com a variável ecológica e sua visão estratégica são consideradas com vistas a elucidar a maneira como ela tem tratado a questão, tanto como ameaça quanto como oportunidade.With the Industrial Revolution, the use of natural resources has improved a lot. Because their limitation, the necessity of dealing with development and environmental preservation creates one of the most important question of nowadays. Then the relation between enterprises and environment is a key point to try to decrease the impact of man over natural enviroment. The case of Hering Têxtil, one of the most important textil industries worldwide, is presented. Its relation with enviroment and the strategic view is considered.

  10. Bloqueio do nervo supraescapular: procedimento importante na prática clínica. Parte II Suprascapular nerve block: important procedure in clinical practice. Part II

    Directory of Open Access Journals (Sweden)

    Marcos Rassi Fernandes

    2012-08-01

    Full Text Available O bloqueio do nervo supraescapular é um método de tratamento reprodutível, confiável e extremamente efetivo no controle da dor no ombro. Esse método tem sido amplamente utilizado por profissionais na prática clínica, como reumatologistas, ortopedistas, neurologistas e especialistas em dor, na terapêutica de enfermidades crônicas, como lesão irreparável do manguito rotador, artrite reumatoide, sequelas de AVC e capsulite adesiva, o que justifica a presente revisão (Parte II. O objetivo deste estudo foi descrever as técnicas do procedimento e suas complicações descritas na literatura, já que a primeira parte reportou as indicações clínicas, drogas e volumes utilizados em aplicação única ou múltipla. Apresentamse, detalhadamente, os acessos para a realização do procedimento tanto direto como indireto, anterior e posterior, lateral e medial, e superior e inferior. Diversas são as opções para se realizar o bloqueio do nervo supraescapular. Apesar de raras, as complicações podem ocorrer. Quando bem indicado, este método deve ser considerado.The suprascapular nerve block is a reproducible, reliable, and extremely effective treatment method in shoulder pain control. This method has been widely used by professionals in clinical practice such as rheumatologists, orthopedists, neurologists, and pain specialists in the treatment of chronic diseases such as irreparable rotator cuff injury, rheumatoid arthritis, stroke sequelae, and adhesive capsulitis, which justifies the present review (Part II. The objective of this study was to describe the techniques and complications of the procedure described in the literature, as the first part reported the clinical indications, drugs, and volumes used in single or multiple procedures. We present in details the accesses used in the procedure: direct and indirect, anterior and posterior, lateral and medial, upper and lower. There are several options to perform suprascapular nerve block

  11. A cobertura de ciência em três jornais paraenses: um estudo longitudinal

    Directory of Open Access Journals (Sweden)

    Vanessa Brasil de Carvalho

    Full Text Available Resumo Neste artigo, apresentamos uma proposta metodológica visando realizar um estudo longitudinal que fornecesse um panorama da cobertura de ciência em 130 anos, por três jornais importantes do Estado do Pará: A Província do Pará (1876-2002, Folha do Norte (1896-1974 e O Liberal (1946-atual. Analisamos um período de dois meses a cada dez anos, de 1876 a 2006, em cada jornal selecionado, de maneira que obtivemos um olhar em longo prazo que perpassou pela história dos periódicos e, portanto, por grande parte da história da imprensa no Pará e na Amazônia. Utilizamos análise de conteúdo e análise de frames da Mídia. Nossos dados mostram que houve ênfase na pesquisa em saúde, destaque para a ciência nacional e preocupação em contextualizar os fatos científicos. Controvérsias e incertezas científicas ganharam pouco espaço nos jornais analisados.

  12. DE BATESON A INGOLD: PASSOS NA CONSTITUIÇÃO DE UM PARADIGMA ECOLÓGICO

    Directory of Open Access Journals (Sweden)

    Otávio Velho

    2001-10-01

    Full Text Available Em 2000 foi finalmente reeditado o mais importante livro de Gregory Bateson, Steps to an Ecology of Mind. Nesse mesmo ano, foi lançado o livro de Tim Ingold, The Perception of the Environment, que retoma muitas das preocupações de Bateson. Este ensaio considera que esses dois eventos marcam passos importantes na constituição de um "paradigma ecológico", o qual vem responder a alguns dilemas que rondam a antropologia e abrir perspectivas para um diálogo interdisciplinar em novas bases.Gregory Bateson’s most important book, Steps to an Ecology of Mind, was finally re-edited in 2000. In the same year, Tim Ingold’s book, The Perception of the Environment, which takes up many of Bateson’s preocupations, was released. This essay proposes that these two events represent important steps towards an "ecological paradigm", which attempts to answer some of anthropology’s dilemas, and open up perspectives for interdisciplinary dialogue on new terms.

  13. Indicadores de sustentabilidade: um levantamento dos principais sistemas de avaliação

    Directory of Open Access Journals (Sweden)

    Hans Michael Van Bellen

    Full Text Available Este artigo apresenta os resultados de um levantamento cujo objetivo é determinar as principais metodologias de avaliação para mensurar a sustentabilidade do desenvolvimento. Para isso, discute a crise ambiental e suas principais conseqüências, até o surgimento do conceito de desenvolvimento sustentável. Esse conceito, por sua vez, é observado a partir de diferentes abordagens que visam evidenciar a necessidade de um conhecimento mais aprofundado dos diferentes sistemas de indicadores de sustentabilidade e de sua utilização. Sistemas de indicadores de desenvolvimento sustentável podem constituir uma importante ferramenta de gestão ambiental, pública ou privada, à medida que consigam orientar e mensurar o desenvolvimento. Entretanto, para alcançar esse objetivo, é necessário conhecer melhor as metodologias existentes. Nesse sentido, o primeiro passo para conhecer melhor as ferramentas de avaliação do desenvolvimento é determinar quais as mais importantes em termos de reconhecimento internacional.

  14. O USO DE UMA ATIVIDADE EXPERIMENTAL COMO RECURSO PEDAGÓGICO PARA AVALIAR AS DIFICULDADES DOS ALUNOS EM UM CONTEÚDO DE FÍSICA

    OpenAIRE

    Leonardo Santos Cunha; Maria Bethânia Fochi dos Santos

    2017-01-01

    Este trabalho traz uma proposta de avaliação pedagógica que utiliza os dados de uma atividade experimental para mapear as dificuldades dos alunos em um conteúdo específico para assim orientar a próxima prática pedagógica. Com um caráter verificativo, a atividade foi elaborada utilizando um experimento de movimento retilíneo uniforme, o qual, através de um roteiro orientado, gerou os dados necessários para ser feita uma análise técnica desses dados e retirar as informações importantes. Enfim, ...

  15. Concepção e estudo de um biofiltro para tratamento de compostos orgânicos voláteis COVs

    OpenAIRE

    Alves, Marileide Moraes

    2005-01-01

    Na ultima década, a purificação biológica de rejeitos gasosos tem sido uma importante alternativa em detrimento dos métodos convencionais de tratamento. Mais recentemente, a biofiltração tem se mostrado um método efetivo e de baixo custo para tratamento de ar contaminado com compostos orgânicos voláteis (COVs). O biofiltro é um reator que possui um leito filtrante constituído por um material poroso, onde estão fixados os microrganismos. Durante o processo de biofiltração, o ar poluído é trans...

  16. Um ensaio de psicologia narrativa

    OpenAIRE

    Alves, António Ribeiro

    2008-01-01

    Texto da lição integrada no concurso de provas públicas para recrutamento de um Professor Coordenador para a Escola Superior de Educação, na área científica da Psicologia Narrativa organizado nas seguintes três secções: (1) O mapa cognitivo; (2) A narrativa como meio de construção das significações pessoais. (3) Limites práticos e teóricos e explorações no domínio da criatividade.

  17. Rumo a um marketing contratual?

    OpenAIRE

    Coelho, Arnaldo; Almeida, Filipe

    2002-01-01

    A fidelização dos clientes tornou-se a prioridade das estratégias de marketing. O marketing relacional preocupou-se em construir relações fortes e duradouras com seus clientes, com base numa perspectiva pessoal e emocional. A teoria dos custos de transação criou o cenário para o aparecimento de uma nova abordagem de marketing. O marketing contratual é proposto como uma nova perspectiva que proporciona todo um conjunto de práticas suscetíveis de criar barreiras à saída dos clientes e de conduz...

  18. Itatiaia Patrulha: um radiojornal popular

    OpenAIRE

    Fabíola Carolina Souza; Universidade Federal de Minas Gerais

    2014-01-01

    O Itatiaia Patrulha é um radiojornal policial, veiculado pela Rádio Itatiaia. Por lidar com o sofrimento das pessoas e trazer seus sentimentos e emoções para a reportagem, o programa comumente é associado ao sensacionalismo, sendo este conceito, muitas vezes, usado pelo senso comum como sinônimo de exploração dos fatos e dramas humanos. No entanto, acreditamos que por seu caráter generalizado, este conceito não nos ajuda a c...

  19. Quanto mais me bates mais gosto de ti: um estudo exploratório sobre a violência no namoro

    OpenAIRE

    Cristovão, Catarina Morgado

    2012-01-01

    Dissertação de Mestrado apresentada ao ISPA - Instituto Universitário, na especialidade de Psicologia Clínica. Tema: Quanto mais me bates mais gosto de ti: um Estudo Exploratório sobre a Violência no Namoro. Problema: A violência no namoro constitui um problema social muito importante nas relações românticas dos jovens e adultos. O comportamento do jovem vai estabelecer os padrões de relacionamento pessoal e relacional no futuro quando forem adultos. Recentemente, pesquisas têm vindo a obs...

  20. Controle de Qualidade dos Serv iços de Auditoria Independente: Um Estudo Compara tivo entre as Normas Brasileiras e as Normas Internacionais

    OpenAIRE

    Ito, Elisabeth Yukie Horita; Niyama, Jorge Katsumi; Mendes, Paulo César de Melo

    2008-01-01

    A atividade de auditoria independente exerce um papel importante no bom funcionamento do mercado por contribuir para maior confiabilidade das informações quanto à sua transparência e adequação de forma independente e com base em procedimentos técnicos e profissionais. Para assegurar a qualidade dos serviços prestados pela auditoria independente é necessário um efetivo controle de qualidade desses serviços. A mencionada qualidade está diretamente relacionada à independência e à compe...

  1. Controle de Qualidade dos Serv iços de Auditoria Independente: Um Estudo Compara tivo entre as Normas Brasileiras e as Normas Internacionais

    OpenAIRE

    Elisabeth Yukie Horita Ito; Jorge Katsumi Niyama; Paulo César de Melo Mendes

    2009-01-01

    A atividade de auditoria independente exerce um papel importante no bom funcionamento do mercado por contribuir para maior confiabilidade das informações quanto à sua transparência e adequação de forma independente e com base em procedimentos técnicos e profissionais. Para assegurar a qualidade dos serviços prestados pela auditoria independente é necessário um efetivo controle de qualidade desses serviços. A mencionada qualidade está diretamente relacionada à independência e à competênc...

  2. Violência intrafamiliar: um estudo com mães agressoras usuárias de álcool e drogas

    OpenAIRE

    Daniela Borges Bittar

    2010-01-01

    A violência é considerada, mundialmente, violação de direitos, embora com expressões variadas em diferentes contextos. Não bastam para seu controle apenas apelos aos sensos de responsabilidade ética e social dos indivíduos. Trata-se, antes, da redefinição desses sensos, do ponto de vista moral e legal. Historicamente, a violência atinge todos os setores da sociedade, sendo um fenômeno multideterminado. Compreender os determinantes da violência é um dos importantes passos, na saúde pública, pa...

  3. O estilo de vida de pacientes hipertensos de um programa de exercício aeróbico: estudo na Cidade de Toluca, México

    OpenAIRE

    Reza,Cleotilde Garci; Nogueira,Maria Suely

    2008-01-01

    A hipertensão arterial, assintomática e desconhecida pela maioria dos seus por tadores, é importante fator de risco para complicações cardiovasculares e renais. Este é um estudo quantitativo e descritivo. Objetivou identificar os estilos de vida associados ao incremento do descontrole da pressão ar terial em pacientes hipertensos que acodem a um programa de exercício. A coleta dos dados ocorreu num centro de saúde do município do Toluca, México, durante agosto 2006 a março 2007. Foi utilizado...

  4. O ESTILO DE VIDA DE PACIENTES HIPERTENSOS DE UM PROGRAMA DE EXERCÍCIO AERÓBIO: ESTUDO NA CIDADE DE TOLUCA, MÉXICO

    OpenAIRE

    Cleotilde Garci Reza

    2008-01-01

    A hipertensão arterial, assintomática e desconhecida pela maioria dos seus por tadores, é importante fator de risco para complicações cardiovasculares e renais. Este é um estudo quantitativo e descritivo. Objetivou identificar os estilos de vida associados ao incremento do descontrole da pressão ar terial em pacientes hipertensos que acodem a um programa de exercício. A coleta dos dados ocorreu num centro de saúde do município do Toluca, México, durante agosto 2006 a março 2007. Foi utilizado...

  5. Aripiprazole (intramuscular) for psychosis-induced aggression or agitation (rapid tranquillisation).

    Science.gov (United States)

    Ostinelli, Edoardo G; Jajawi, Salwan; Spyridi, Styliani; Sayal, Kamlaj; Jayaram, Mahesh B

    2018-01-08

    People experiencing psychosis may become aggressive. Antipsychotics, such as aripiprazole in intramuscular form, can be used in such situations. To evaluate the effects of intramuscular aripiprazole in the treatment of psychosis-induced aggression or agitation (rapid tranquillisation). On 11 December 2014 and 11 April 2017, we searched the Cochrane Schizophrenia Group's Study-based Register of Trials which is based on regular searches of CINAHL, BIOSIS, AMED, Embase, PubMed, MEDLINE, PsycINFO, and registries of clinical trials. All randomised controlled trials (RCTs) that randomised people with psychosis-induced aggression or agitation to receive either intramuscular aripiprazole or another intramuscular intervention. We independently inspected citations and, where possible, abstracts, ordered papers and re-inspected and quality assessed these. We included studies that met our selection criteria. At least two review authors independently extracted data from the included studies. We chose a fixed-effect model. We analysed dichotomous data using risk ratio (RR) and the 95% confidence intervals (CI). We analysed continuous data using mean differences (MD) and their CIs. We assessed risk of bias for included studies and used GRADE to create 'Summary of findings' tables. Searching found 63 records referring to 21 possible trials. We could only include three studies, all completed over the last decade, with 885 participants, of which 707 were included for quantitative analyses in this systematic review. Due to limited comparisons, small size of trials and a paucity of investigated and reported 'pragmatic' outcomes, evidence was mostly graded as low or very low quality. No trials reported useful data for one of our primary outcomes of tranquil or asleep by 30 minutes. Economic outcomes were also not reported in the trials.When compared with placebo, fewer people in the aripiprazole group needed additional injections compared to the placebo group (2 RCTs, n = 382, RR 0

  6. 178. La neumonía asociada a ventilación mecánica es un importante factor de riesgo de mortalidad en los pacientes sometidos a cirugía cardíaca mayor

    Directory of Open Access Journals (Sweden)

    J. Bustamante

    2012-04-01

    Conclusiones: El desarrollo de la neumonía en el postoperatorio inmediato de cirugía cardíaca es un factor independiente de riesgo muy importante de mortalidad. Se deben extremar las medidas demostradas de utilidad a fin de disminuir su incidencia.

  7. Health worker and policy-maker perspectives on use of intramuscular artesunate for pre-referral and definitive treatment of severe malaria at health posts in Ethiopia.

    Science.gov (United States)

    Kefyalew, Takele; Kebede, Zelalem; Getachew, Dawit; Mukanga, David; Awano, Tessema; Tekalegne, Agonafer; Batisso, Esey; Edossa, Wasihun; Mekonnen, Emebet; Tibenderana, James; Baba, Ebenezer Sheshi; Shumba, Constance; Nankabirwa, Joaniter I; Hamade, Prudence

    2016-10-18

    The World Health Organization (WHO) recommends injectable artesunate given either intravenously or by the intramuscular route for definitive treatment for severe malaria and recommends a single intramuscular dose of intramuscular artesunate or intramuscular artemether or intramuscular quinine, in that order of preference as pre-referral treatment when definitive treatment is not possible. Where intramuscular injections are not available, children under 6 years may be administered a single dose of rectal artesunate. Although the current malaria treatment guidelines in Ethiopia recommend intra-rectal artesunate or alternatively intramuscular artemether or intramuscular quinine as pre-referral treatment for severe malaria at the health posts, there are currently no WHO prequalified suppliers of intra-rectal artesunate and when available, its use is limited to children under 6 years of age leaving a gap for the older age groups. Intramuscular artesunate is not part of the drugs recommended for pre-referral treatment in Ethiopia. This study assessed the perspectives of health workers, and policy-makers on the use of intramuscular artesunate as a pre-referral and definitive treatment for severe malaria at the health post level. In-depth interviews were held with 101 individuals including health workers, malaria focal persons, and Regional Health Bureaus from Oromia and southern nations, nationalities, and peoples' region, as well as participants from the Federal Ministry of Health and development partners. An interview guide was used in the data collection and thematic content analysis was employed for analysis. Key findings from this study are: (1) provision of intramuscular artesunate as pre-referral and definitive treatment for severe malaria at health posts could be lifesaving; (2) with adequate training, and provision of facilities including beds, health posts can provide definitive treatment for severe malaria using intramuscular artesunate where referral is

  8. Health worker and policy-maker perspectives on use of intramuscular artesunate for pre-referral and definitive treatment of severe malaria at health posts in Ethiopia

    Directory of Open Access Journals (Sweden)

    Takele Kefyalew

    2016-10-01

    Full Text Available Abstract Background The World Health Organization (WHO recommends injectable artesunate given either intravenously or by the intramuscular route for definitive treatment for severe malaria and recommends a single intramuscular dose of intramuscular artesunate or intramuscular artemether or intramuscular quinine, in that order of preference as pre-referral treatment when definitive treatment is not possible. Where intramuscular injections are not available, children under 6 years may be administered a single dose of rectal artesunate. Although the current malaria treatment guidelines in Ethiopia recommend intra-rectal artesunate or alternatively intramuscular artemether or intramuscular quinine as pre-referral treatment for severe malaria at the health posts, there are currently no WHO prequalified suppliers of intra-rectal artesunate and when available, its use is limited to children under 6 years of age leaving a gap for the older age groups. Intramuscular artesunate is not part of the drugs recommended for pre-referral treatment in Ethiopia. This study assessed the perspectives of health workers, and policy-makers on the use of intramuscular artesunate as a pre-referral and definitive treatment for severe malaria at the health post level. Methods In-depth interviews were held with 101 individuals including health workers, malaria focal persons, and Regional Health Bureaus from Oromia and southern nations, nationalities, and peoples’ region, as well as participants from the Federal Ministry of Health and development partners. An interview guide was used in the data collection and thematic content analysis was employed for analysis. Results Key findings from this study are: (1 provision of intramuscular artesunate as pre-referral and definitive treatment for severe malaria at health posts could be lifesaving; (2 with adequate training, and provision of facilities including beds, health posts can provide definitive treatment for severe

  9. The neuroprotective effects of intramuscular insulin-like growth factor-I treatment in brain ischemic rats.

    Directory of Open Access Journals (Sweden)

    Heng-Chih Chang

    Full Text Available Brain ischemia leads to muscle inactivity-induced atrophy and may exacerbate motor function deficits. Intramuscular insulin-like growth factor I (IGF-I injection has been shown to alleviate the brain ischemia-induced muscle atrophy and thus improve the motor function. Motor function is normally gauged by the integrity and coordination of the central nervous system and peripheral muscles. Whether brain ischemic regions are adaptively changed by the intramuscular IGF-I injection is not well understood. In this study, the effect of intramuscular IGF-I injection was examined on the central nervous system of brain ischemic rats. Rats were divided into 4 groups: sham control, brain ischemia control, brain ischemia with IGF-I treatment, and brain ischemia with IGF-I plus IGF-I receptor inhibitor treatment. Brain ischemia was induced by right middle cerebral artery occlusion. IGF-I and an IGF-1 receptor inhibitor were injected into the affected calf and anterior tibialis muscles of the treated rats for 4 times. There was an interval of 2 days between each injection. Motor function was examined and measured at the 24 hours and 7 days following a brain ischemia. The affected hind-limb muscles, sciatic nerve, lumbar spinal cord, and motor cortex were collected for examination after euthanizing the rats. IGF-I expression in the central nervous system and affected muscles were significantly decreased after brain ischemia. Intramuscular IGF-I injection increased the IGF-I expression in the affected muscles, sciatic nerve, lumbar spinal cord, and motor cortex. It also increased the p-Akt expression in the affected motor cortex. Furthermore, intramuscular IGF-I injection decreased the neuronal apoptosis and improved the motor function. However, co-administration of the IGF-I receptor inhibitor eliminated these effects. Intramuscular IGF-I injection after brain ischemia attenuated or reversed the decrease of IGF-I in both central and peripheral tissues, and

  10. Irinotecan-loaded double-reversible thermogel with improved antitumor efficacy without initial burst effect and toxicity for intramuscular administration.

    Science.gov (United States)

    Din, Fakhar Ud; Kim, Dong Wuk; Choi, Ju Yeon; Thapa, Raj Kumar; Mustapha, Omer; Kim, Dong Shik; Oh, Yu-Kyoung; Ku, Sae Kwang; Youn, Yu Seok; Oh, Kyung Taek; Yong, Chul Soon; Kim, Jong Oh; Choi, Han-Gon

    2017-05-01

    Intramuscularly administered, anti-tumour drugs induce severe side effects due to their direct contact with body tissues and initial burst effect. In this study, to solve this problem, a novel double-reversible thermogel system (DRTG) for the intramuscular administration of irinotecan was developed. This irinotecan-loaded DRTG was prepared by dispersing the irinotecan-loaded thermoreversible solid lipid nanoparticles (SLNs) in the thermoreversible hydrogel. In DRTG, the former was solid at 25°C but converted to liquid at 36.5°C; in contrast, the latter existed in a liquid form but transformed to gel state in the body. The DRTG was easily administered intramuscularly. Its particle size and drug content were not noticeably changeable, resulting that it was stable at 40°C for at least 6months. Compared to the irinotecan-loaded solution and conventional hydrogel, the DRTG significantly delayed drug release, leading to a reduced burst effect. Moreover, it showed decreased C max and maintained the sustained plasma concentrations at a relatively low level for the long period of 60h in rats, resulting in ameliorated side effects of the anti-tumour drug. Furthermore, it gave significantly improved anti-tumour efficacy in tumour-bearing mice compared to the hydrogel but, unlike the conventional hydrogel, induced no body weight loss and local damage to the muscle. Thus, this DRTG with improved antitumor efficacy without initial burst effect and toxicity could provide a potential pharmaceutical system for the intramuscular administration of irinotecan. Intramuscularly administered, anti-tumour drugs induce severe side effects due to their direct contact with body tissues and initial burst effect. To solve this problem, we developed a novel double-reversible thermogel system (DRTG) for the intramuscular administration of irinotecan. Unlike the conventional hydrogel, the DRTG is a dispersion of the irinotecan-loaded thermoreversible solid lipid nanoparticles in the

  11. Dermatite multifatorial em um canino

    Directory of Open Access Journals (Sweden)

    C.B. Matos

    2012-12-01

    Full Text Available Relatou-se um caso clínico de dermatite multifatorial em cão, envolvendo Demodex canis, Sporothrix schenckii e bactérias dos gêneros Staphylococcus e Streptococcus. O animal, macho, da raça Pit Bull, com um ano e três meses de idade, apresentou lesões úmidas, hiperêmicas, descamativas e ulcerativas nas regiões do pescoço e do tórax. Exames laboratoriais confirmaram o diagnóstico de infecção concomitante por fungo, bactéria e parasito. A terapia antimicrobiana com moxidectina, itraconazol e amoxicilina foi efetiva, com remissão dos sinais clínicos após 30 dias de tratamento. Este relato salienta a importância do diagnóstico de certeza, que foi determinante para estabelecimento da terapêutica adequada e recuperação do animal.

  12. UM CRISTIANISMO INÉDITO?

    Directory of Open Access Journals (Sweden)

    Mario de França Miranda

    2008-01-01

    Full Text Available Numa primeira parte este artigo oferece aos leitores uma síntese da obra de Charles Taylor intitulada “A era secular”, fiel à seqüência das partes do livro expostas pelo autor e ressaltando o que nos pareceu mais digno de nota. Numa segunda parte apresentamos uma reação pessoal à leitura desta importante obra. Aí aparece como as reflexões de Taylor incidem fortemente em algumas áreas da teologia e questionam seriamente o cristianismo convencional. ABSTRACT: The article’s first part offers to the readers a synthesis of Charles Taylor’s  ”A secular” era” according to the book’s topics presented by the author highlighting what is important to note. In the second part we introduce a personal response to this important work. There appears how Taylor’s reflections strongly involve some areas of Theology and raise serious questions about the conventional Christianity.

  13. Desenvolvimento de um curso on-line sobre o tema administração de medicamentos Desarrollo de un curso via electrónica sobre la administración de medicamentos Development of a on-line course about administration of medication

    OpenAIRE

    Silvia Helena De Bortoli Cassiani; Flávia Borges da Silva Benfati; Denise Costa Dias; Silvia Helena Zem-Mascarenhas; Maria Lúcia Zanetti

    2003-01-01

    O estudo descreveu o desenvolvimento de um curso on-line sobre o processo da administração de medicamentos - vias. Para tanto se utilizou o World Wide Web Course Tools (WebCT), que é um software que fornece várias ferramentas a supervisores e acesso a estudantes providos de uma senha a diversos ambientes. O material do curso foi subdivido em oito tópicos ilustrados: administração de medicamentos por via oral, sublingual, via parenteral, intradérmica, subcutânea, intramuscular, endovenosa e ap...

  14. Clinical comparison of preanaesthetic intramuscular medetomidine and dexmedetomidine in domestic sheep.

    Science.gov (United States)

    Kastner, S B; Boller, M; Kutter, A; Akens, M K; Bettschart-Wolfensberger, R

    2001-10-01

    Medetomidine and its active d-enantiomer, dexmedetomidine, are highly selective alpha-2 agonists with potent sedative, anaesthetic-sparing and analgesic effects. These properties make them an ideal pre-anaesthetic medication for noxious surgical procedures. However, sheep can develop adverse hypoxaemic effects after intravenous alpha-2 agonists. Objective of the present study was to compare intramuscular injection of medetomidine or dexmedetomidine at equipotent doses as preanaesthetic medication prior to isoflurane anaesthesia in sheep. Nineteen healthy, adult, non-pregnant, female sheep of various breeds were used. The study was carried out as a randomised, blind trial. Group A received 15 micrograms/kg bwt dexmedetomidine and group B received 30 micrograms/kg bwt medetomidine intramuscularly (i.m.) 30 minutes prior to induction of anaesthesia. Anaesthesia was induced with ketamine (2.0 mg/kg bwt i.v.) and maintained with isoflurane in 100% oxygen. End expired anaesthetic concentration (FEiso), respiratory frequency (fR), direct arterial blood pressures and heart rates (HR) were measured. Arterial blood samples were taken at intervals. Data were averaged over time (sum of measurements/number of measurements) and tested for differences between groups by independent t-tests, and ANOVA for repeated measures followed by Bonferroni corrected t-tests. There were no differences in demographic data between the groups. Duration of anaesthesia [A: 170 (42) minutes, B: 144 (33) minutes] and duration of surgery [A: 92 (32) minutes, B: 85 (31) minutes] were similar in both groups. Average FEiso concentrations required to maintain a surgical plane of anaesthesia were not significantly different between groups [A: 0.82 (0.14)%; B: 1.00 (0.25)%]. Mean average fR, did not differ between groups [A: 31 (14), B: 37 (15)]. Heart rates were significantly lower in group B over the course of the anaesthesia. Mean arterial blood pressures (MAP) were not significantly different between

  15. Lipid composition of covering and intramuscular fat in pigs at different slaughter age

    Directory of Open Access Journals (Sweden)

    Piero Santoro

    2010-04-01

    Full Text Available To study age-related variations in fatty acid composition of covering and intramuscular fat (IMF, 60 half siblings, Pic X Camborough, of the same age, 30 barrows and 30 gilts, chosen from 10 litters were used. Groups of 20 subjects each, 10 castrated males and 10 females, balanced for litter, were sacrificed at 6, 8.5 and 9.5 months of age, corresponding to the common slaughter age of the three Italian pig production types, at live weights averaging approximately 90, 145 and 160 kg, respectively. Samples of backfat and longissimus thoracis (LT muscle, taken at the last rib, were analysed. On LT samples, moisture, fat content and drip loss were determined. Fatty acid composition was determined in lipids from subcutaneous adipose tissue and in lipid fractions from LT. Further, backfat lipids were submitted to iodine value (I.V. determination. The data were evaluated by means of analysis of variance with age at slaughter and sex as the independent variables. As age increased (6, 8.5 and 9.5 months, higher contents of saturated fatty acids (SFA (36.36, 39.08 and 39.19%, respectively; P<0.01 and monounsaturated fatty acids (MUFA (41.78, 43.44 and 44.37%, respectively; P<0.01 were observed in backfat, whereas polyunsaturated fatty acids (PUFA content, PUFA/SFA ratio and I.V. lowered (P<0.01. As total IMF is concerned, by increasing age, MUFA content increased (43.30; 46.76 and 47.28%, respectively; P<0.01, PUFA content decreased (18.63, 15.14 and 14.82%, respectively; P<0.01 and PUFA/SFA decreased as well (P<0.05; neutral lipids followed the same pattern, while an opposite trend was observed in polar lipids. IMF content (1.65% was modified neither by sex nor age. The study shows that fatty acids composition of subcutaneous and intramuscular fats differs among the 3 slaughtering ages typical of the Italian pig industry. The variations observed, which could be ascribed to the increase of carcass fatness at increasing slaughter age, can affect both the

  16. Comparison of intramuscular alfaxalone and ketamine combined with dexmedetomidine and butorphanol for castration in cats.

    Science.gov (United States)

    Khenissi, Latifa; Nikolayenkova-Topie, Olga; Broussaud, Ségolène; Touzot-Jourde, Gwenola

    2017-08-01

    Objectives Cardiorespiratory parameters and anaesthesia quality in cats anaesthetised with either intramuscular (IM) alfaxalone or ketamine both combined with dexmedetomidine and butorphanol for castration were evaluated. Methods Thirty-two client-owned cats were randomly assigned to receive either alfaxalone (A; 3 mg/kg IM) or ketamine (K; 5 mg/kg IM), combined with dexmedetomidine (10 μg/kg) and butorphanol (0.2 mg/kg). Heart rate (HR), respiratory rate (RR) and rectal temperature (T°) were recorded prior to drug administration. Pulse rate (PR) and RR were recorded 10 (T 10 ) and 15 (T 15 ) mins after injection (T 0 ). Cardiorespiratory values (PR, RR, SPO 2 , blood pressure, P E 'CO 2 ) were recorded every 5 mins for the duration of the procedure. Pain at injection, intubation and recovery were evaluated with simple descriptive scores. Feasibility of anaesthesia was evaluated by the number of top-ups of anaesthetic needed. Cat attitude, ability to walk and presence of ataxia were assessed several times after extubation (T exmin ) and the time between injection and extubation recorded. Pain was assessed at T ex120 and T ex240 with the 4Avet-pain score. Results The RR was significantly lower in group K at T 10 (RR K = 28 ±13.35 breaths per minute [brpm], RR A = 43.24 ±7.04 brpm) and T 15 (RR K = 28 ±11.53 brpm vs RR A = 43 ±12.18 brpm). Time to extubation was significantly longer in group A (T A = 62 ±14.6 mins, T K = 45.13 ± 7.38 mins). Cats in group K needed more top-ups, were more ataxic at T ex120 , had a worse recovery score at T ex60 and were less willing to walk at T ex30 . Conclusions and relevance Cats receiving alfaxalone had a longer but better quality recovery. Cardiorespiratory parameters were stable and within clinically acceptable values following IM injection of either alfaxalone or ketamine in healthy cats. Intramuscular alfaxalone is a suitable alternative to ketamine for short procedures requiring anaesthesia when used in combination

  17. Ano Novo: novas conquistas, novos desafios e um mesmo compromisso

    Directory of Open Access Journals (Sweden)

    André Luís Gemal

    2014-02-01

    Full Text Available Neste mês de fevereiro de 2014 lançamos o primeiro número do nosso segundo volume, mantendo assim o cronograma programado e a periodicidade proposta para nossa revista Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia. Após sua inserção no sistema Qualis, da Capes, ao final do ano passado, iniciamos 2014 com novas e importantes conquistas, entre elas, a inclusão na base de dados do Latindex e a nossa participação no sistema de classificação DOI. Neste segundo ano de vida da Vigilância Sanitária em Debate permanecemos com o mesmo compromisso de estimular a divulgação de saberes da área que, por vezes, estiveram sem espaço apropriado em veículos de divulgação reconhecidos no campo da saúde pública. O corpo editorial toma essa perspectiva como um desafio constante de nossa revista.

  18. Corpo & Gênero: Articulando Um Debate

    OpenAIRE

    Carla Cristina Lima de Almeida

    2012-01-01

      O artigo examina as relações entre corpo e gênero, problematizando a tese de que o corpo constitui uma base fixa sobre a qual se fundamenta o gênero. A partir de um estudo bibliográfico, apresenta argumentos que evidenciam o corpo e o sexo envolvidos em intensas práticas discursivas sobre o “eu” e a ordem social; constituindo-se, portanto, também em instâncias dinâmicas e mutáveis. O trabalho investiga ainda algumas construções contempo-râneas em torno do corpo, destacando questi...

  19. Adenocarcinoma pulmonar em um bovino

    OpenAIRE

    Viott,Aline de Marco; Langohr,Ingeborg Maria; Vannucci,Fábio Augusto; Almeida,Aliny Pontes; Leite,Rômulo Cerqueira; Ecco,Roselene

    2010-01-01

    Um bovino Guzerá, fêmea, adulto, com histórico de insuficiência cardíaca congestiva direita de duração de duas semanas, morreu durante o transporte ao hospital veterinário. À necropsia, o lobo pulmonar cranial esquerdo estava moderadamente aumentado de tamanho e firme. O parênquima do lobo afetado era branco e continha múltiplas áreas de 0,3 a 1,5cm de diâmetro, amareladas e caseosas. Alterações semelhantes foram observadas nos linfonodos mediastínicos e brônquicos, no pericárdio parietal, no...

  20. C8. Um caso singular de tuberculose

    Directory of Open Access Journals (Sweden)

    Carlos Lopes

    2003-11-01

    Full Text Available Doente sexo masculino, 50 anos, raça negra, HIV -, fumador, hábitos etílicos importantes, baixo nível sócio-económico. Internado por quadro com dois meses de evolução de: febre, suores nocturnos, tosse, expectoração, emagrecimento (20 Kg/3 M, anorexia, astenia, seguido por: náuseas, vómitos, distensão e dor abdominais. O exame objectivo revelou: fervores na auscultação pulmonar e hepatomegália. Raio-X Tórax: infiltrado alvéolointersticial difuso bilateral. Ecografia abdominal: hepatomegália e ascite. Paracentese: ascite quilosa; pleocitose linfocítica; teste cutâneo de tuberculina +. Exame bacteriológico da expectoração: M. tuberculosis. Parâmetros inflamatórios de fase aguda aumentados; TC Torácica: consolidação do lobo superior direito; opacidades nodulares bilaterais, derrame pleural esquerdo, liquído intraperitoneal; hepatomegália heterogénea; infiltração da gordura mesentérica e espessamento parietal.Durante o internamento, iniciou diarreia e dor abdominal intensa. A colonoscopia revelou estenose parcial do íleon terminal, processo inflamatório; úlceras da sigmóideia. Histologia: infiltrado inflamatório linfocítico e granulomas epitelióides com células gigantes multinucleadas. Alguns bacilos álcool-ácido resistentes (ZN.Foi administrada terapêutica quádrupla (HRZE desde o 2.º dia de internamento. Ao 47.º dia de internamento, verificou-se um agravamento da dor abdominal. Diagnóstico final: Tuberculose Pulmonar, Gastrointestinal e Peritoneal.Actualmente, o envolvimento do tracto gastrointestinal e peritoneu é raro, geralmente resultante de disseminação hematogénea. : Male patient, 50 years old, african, HIV ˜, smoker, heavy etanolic habits, low socioeconomic status. He was admitted to our department due to fever, night sweats, cough, sputum, weight loss (20Kg/ 3 M, anorexia

  1. Pharmacokinetic Evaluation of a Single Intramuscular High Dose versus an Oral Long-Term Supplementation of Cholecalciferol.

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    Katharina Wylon

    Full Text Available Vitamin D deficiency is frequent during the winter and occurs throughout the year in the elderly or patients suffering from autoimmune diseases. The objective of this study was to evaluate the pharmacokinetic properties of oral supplementation versus a single intramuscular injection of cholecalciferol in healthy individuals.Up to 8,000 I.U. oral cholecalciferol was administered daily for 84 days in a 4 week dose-escalation setting to vitamin D deficient individuals. In another cohort, a single intramuscular injection of 100,000 I.U. cholecalciferol was given. In both cohorts, individuals without vitamin D intake served as the comparison group. 25-hydroxyvitamin D (25(OHD concentrations were measured in all individuals at defined time points throughout the studies.The mean 25(OHD serum concentration increased significantly after oral cholecalciferol intake compared to the control group (day 28: 83.4 nmol/l and 42.5 nmol/l; day 56: 127.4 nmol/l and 37.3 nmol/l; day 84: 159.7 nmol/l and 30.0 nmol/l. In individuals receiving 100,000 I.U. cholecalciferol intramuscular, the mean 25(OHD serum concentration peaked after 4 weeks measuring 70.9 nmol/l compared to 32.7 nmol/l in the placebo group (p = 0.002. The increase of 25(OHD serum concentrations after 28 days was comparable between both routes of administration (p = 0.264.Oral and intramuscular cholecalciferol supplementation effectively increased serum 25(OHD concentrations.

  2. Antibody-Secreting Cell Responses and Protective Immunity Assessed in Gnotobiotic Pigs Inoculated Orally or Intramuscularly with Inactivated Human Rotavirus†

    OpenAIRE

    Yuan, Lijuan; Kang, S.-Y.; Ward, Lucy A.; To, Thanh L.; Saif, Linda J.

    1998-01-01

    Newborn gnotobiotic pigs were inoculated twice perorally (p.o.) (group 1) or intramuscularly (i.m.) (group 2) or three times i.m. (group 3) with inactivated Wa strain human rotavirus and challenged with virulent Wa human rotavirus 20 to 24 days later. To assess correlates of protection, antibody-secreting cells (ASC) were enumerated in intestinal and systemic lymphoid tissues from pigs in each group at selected postinoculation days (PID) or postchallenge days. Few virus-specific ASC were dete...

  3. Intramuscular Castleman's disease of the deltoid: a case report and review of the literature

    Energy Technology Data Exchange (ETDEWEB)

    Hakozaki, Michiyuki; Tajino, Takahiro; Yamada, Hitoshi; Kikuchi, Shinichi; Konno, Shinichi [Fukushima Medical University School of Medicine, Department of Orthopaedic Surgery, Fukushima (Japan); Hashimoto, Yuko [Fukushima Medical University School of Medicine, Department of Pathology and Diagnostic Pathology, Fukushima (Japan)

    2010-07-15

    Castleman's disease (CD), a rare benign disease characterized by lymphoid hyperplasia, typically arises in the mediastinum as a solitary tumor. We describe herein a rare case of intramuscular CD occurring in the left deltoid in a 28-year-old woman. The present case is instructive in the differential diagnosis of primary soft tissue tumors, for which the possibility of CD should be considered. (orig.)

  4. Spinal cord glia and interleukin-1 do not appear to mediate persistent allodynia induced by intramuscular acidic saline in rats.

    Science.gov (United States)

    Ledeboer, Annemarie; Mahoney, John H; Milligan, Erin D; Martin, David; Maier, Steven F; Watkins, Linda R

    2006-10-01

    Spinal glial activation and consequent interleukin-1 (IL-1) release are implicated in pain facilitation induced by inflammation/damage to skin and peripheral nerves. It is unclear whether pain facilitation induced at deep tissue sites also depends on these. We investigated whether spinal IL-1 and/or glial activation mediates bilateral allodynia induced by repeated unilateral intramuscular injections of acidic saline to rats. Given the prominent role of spinal IL-1 in various bilateral pain models, we predicted that intrathecal IL-1 receptor antagonist (IL-1ra) would suppress bilateral allodynia in this model as well. Surprisingly, neither single nor repeated intrathecal injections of IL-1ra affected allodynia, measured by the von Frey test, induced by prior intramuscular acidic saline compared with vehicle-injected controls. In addition, we tested the effect of 2 additional intrathecal manipulations that are broadly efficacious in suppressing glially mediated pain facilitation: (1) a glial metabolic inhibitor (fluorocitrate) and (2) the anti-inflammatory cytokine, interleukin-10 (IL-10). Like IL-1ra, fluorocitrate and IL-10 each failed to reverse allodynia. Finally, we observed no significant activation of glial cells, as assessed by immunohistochemistry of glial activation markers, in the lumbar spinal cord in response to intramuscular acidic saline. Taken together, the present data suggest that acidic saline-induced bilateral allodynia is created independently of glial activation. From converging lines of evidence, the current studies suggest that persistent bilateral allodynia induced by repeated intramuscular acidic saline is not mediated by spinal IL-1 and/or spinal glial activation. As such, this might represent the first evidence for pain facilitation occurring in the absence of glial involvement.

  5. Haematological and biochemical alterations caused by epidural and intramuscular administration of xylazine hydrochloride in dromedary camels (Camelus dromedarius)

    OpenAIRE

    Omid Azari; Mohammad Mahdi Molaei; Ladan Emadi; Ehsanollah Sakhaee; Hamid Sharifi; Sara Mehdizadeh

    2012-01-01

    This study was conducted in 16 healthy immature dromedary camels weighing 120-150 kg to evaluate and compare the effects of epidural and intramuscular injections of xylazine administered at 0.1 mg/kg and 0.2 mg/kg. Haematological parameters included haemoglobin, packed cell volume, total erythrocyte count and total leukocyte count. Biochemical parameters included alkaline phosphates, alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, creatinine and glucose. Parameters ...

  6. Epidural vs intramuscular administration of lecirelin, a GnRH analogue, for the resolution of follicular cysts in dairy cows.

    Science.gov (United States)

    Rizzo, Annalisa; Annalisa, Rizzo; Campanile, Debora; Debora, Campanile; Mutinati, Maddalena; Maddalena, Mutinati; Minoia, Giuseppe; Giuseppe, Minoia; Spedicato, Massimo; Massimo, Spedicato; Sciorsci, Raffaele Luigi; Luigi, Sciorsci Raffaele

    2011-06-01

    Bovine follicular cysts are an ovarian disorder of dairy cows associated with abnormal estrous behaviour and infertility. The treatment of choice is intramuscular administration of a GnRH analogue, which acts by triggering pituitary release of LH. However, the presence of GnRH and GnRH receptors on spinal cord and ovary in some species, and the kind of innervation of the ovary, let us hypothesize that GnRH and its analogues may also act when administered by epidural route, as happens for other drugs. Therefore the aim of this study was to compare the effects of epidural vs intramuscular administration of lecirelin (a GnRH analogue) on FC regression, estrus detection and pregnancy outcomes. The study was conducted on 220 Friesian cows affected by follicular cysts, divided among 4 groups: Group L(epid) and Group L(im) received, respectively 50 μg of lecirelin in the epidural space and intramuscular; Group C(epid) and Group C(im) were used as control groups. In Group L(epid), estrus induction and pregnancy rates were significantly higher than in Group L(im). The results of this study show that the epidural administration of lecirelin promoted the remission of follicular cysts and an improvement of reproductive parameters compared to intramuscular administration. Thus, an alternative therapeutical approach is available for FC treatment, in order to obtain an easier restoration of the ovarian activity, especially in those cases refractory to classical therapeutic approaches. Copyright © 2011 Elsevier B.V. All rights reserved.

  7. Antipyretic efficacy and tolerability of oral ibuprofen, oral dipyrone and intramuscular dipyrone in children: a randomized controlled trial

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    Judith Prado

    Full Text Available CONTEXT AND OBJECTIVE: Dipyrone is a widely used over-the-counter antipyretic in Latin America, and elsewhere among Latin immigrants. Despite limited evidence, physicians often prescribe oral ibuprofen or intramuscular dipyrone as the most effective antipyretics. Our aim was to compare the antipyretic efficacy and tolerability of a single dose of oral ibuprofen, oral dipyrone or intramuscular dipyrone in febrile children. DESIGN AND SETTING: Randomized, single-blind clinical trial, at San Bartolomé Mother-Child National Teaching Hospital, Lima, Peru. METHODS: Children from six months to six years old with fever (rectal temperature: 38.3 to 39.8° C in the emergency ward between February and June 2003 were eligible. Seventy-five children were randomly assigned to receive a single dose of oral ibuprofen (10 mg/kg, oral dipyrone (15 mg/kg or intramuscular dipyrone (15 mg/kg. The primary outcome was mean temperature reduction after 30, 45, 60, 90 and 120 minutes. Secondary outcomes were fever-associated symptoms and clinical adverse events. RESULTS: Fever decreased by about 0.5° C after 45 minutes and by about 1.0° C after 120 minutes in all three groups. Mean temperatures were similar for the three groups at all times. There was a significant decrease in fever-associated symptoms for all groups. Six patients (four receiving oral dipyrone and two receiving ibuprofen were withdrawn because of vomiting within 20 minutes after first dose of study medication. One patient assigned to oral ibuprofen presented transient urticaria. CONCLUSIONS: Antipyretic efficacy and tolerability were similar for oral ibuprofen, oral dipyrone and intramuscular dipyrone. Oral antipyretics seem more appropriate for feverish children.

  8. Intramuscular Delivery of Adenovirus Serotype 5 Vector Expressing Humanized Protective Antigen Induces Rapid Protection against Anthrax That May Bypass Intranasally Originated Preexisting Adenovirus Immunity

    OpenAIRE

    Wu, Shipo; Zhang, Zhe; Yu, Rui; Zhang, Jun; Liu, Ying; Song, Xiaohong; Yi, Shaoqiong; Liu, Ju; Chen, Jianqin; Yin, Ying; Xu, Junjie; Hou, Lihua; Chen, Wei

    2014-01-01

    Developing an effective anthrax vaccine that can induce a rapid and sustained immune response is a priority for the prevention of bioterrorism-associated anthrax infection. Here, we developed a recombinant replication-deficient adenovirus serotype 5-based vaccine expressing the humanized protective antigen (Ad5-PAopt). A single intramuscular injection of Ad5-PAopt resulted in rapid and robust humoral and cellular immune responses in Fisher 344 rats. Animals intramuscularly inoculated with a s...

  9. [Studies on the metabolic fate of isepamicin sulfate (HAPA-B). III. Intramuscular, intravenous and drip intravenous administration of HAPA-B in rabbits].

    Science.gov (United States)

    Suzuki, T; Somiya, Y; Shirai, M; Sakai, A; Iwasaki, M; Morishita, M

    1987-01-01

    Absorption, distribution, metabolism and excretion of isepamicin sulfate (HAPA-B) were studied following intramuscular, intravenous and drip intravenous administration at doses of 6.25, 25 and 100 mg/kg to rabbits. Plasma concentrations of HAPA-B following intramuscular, intravenous and drip intravenous administration depended on dose levels. Biological half-lives (T1/2), body clearance (Clt) and areas under plasma concentration-time curves (AUC) for different routes of administration were similar in all 3 routes. A theoretical curve for drug concentrations vs. time was obtained using pharmacokinetic parameters calculated from drug concentrations in plasma following a 45-minute drip intravenous administration. From the curve, it was estimated that 60 to 90 minutes would be required to achieve a similar maximum drug concentration in plasma by drip intravenous administration to that obtained by intramuscular administration. Thus, drug concentration patterns obtained following intramuscular administration could be duplicated in drip intravenous administration by regulating the length of time for infusion. The concentration of HAPA-B in tissues obtained following a 15-minute drip intravenous administration reached maximum after 15 minutes at a level higher than that achieved by intramuscular administration, but an hour later, concentrations in tissues including the kidney decreased to similar levels obtained following intramuscular administration and patterns of concentration decrease for drip intravenous administration and intramuscular administration were quite similar to each other thereafter. The drug was rapidly excreted into the urine following any of the 3 routes, and urinary recoveries in 24 hours were 75 approximately 92% of dose amounts for all dose levels tested. Bioautograms on thin-layer chromatographs of 0 approximately 6 hours urine samples obtained following an intramuscular administration of the drug showed a single biologically active bands with

  10. Randomized clinical trial to assess pain and bruising in medicines administered by means of subcutaneous and intramuscular needle injection: Is it necessary to have needles changed?

    OpenAIRE

    Lamblet, Luiz Carlos Ribeiro; Meira, Edilson Sant'Anna; Torres, Silvana; Ferreira, Barbara Carvalho; Martucchi, Sergio Dias

    2011-01-01

    This clinical trial aimed at comparing the intensity of pain and bruising by subcutaneous and intramuscular injections using and retractable fixed syringes and needles and syringes with no needles combined, at a public hospital in Sao Paulo, for six months. We evaluated the perception of pain in case of intramuscular (n=1000) and subcutaneous injections (n=240). In subcutaneous application, bruise formation was also verified. Pain and bruising scores were higher in the group with no needles c...

  11. The effect of site (deltoid or gluteus muscle) of intramuscular administration of anaesthetic drugs on the course of immobilisation in macaque monkeys (Macaca mulatta)

    OpenAIRE

    Ladislav Hess; Jiří Málek; Alice Kurzová; Martin Votava

    2012-01-01

    The aim of this work was to study the effect of site of intramuscular administration of anaesthetic drugs on the course of immobilisation in macaque monkeys (Macaca mulatta). Twenty macaque monkeys were given medetomidine (25 µg·kg-1) and ketamine (3 mg·kg-1) intramuscularly to the deltoid (n = 10 animals) or gluteus (n = 10 animals) muscles. Behavioural changes, loss of aggressiveness, immobilisation time and cardiorespiratory changes were recorded. The effect of drugs was reversed after 20 ...

  12. Five-day regimen of intramuscular or subcutaneous self-administered adrenocorticotropic hormone gel for acute exacerbations of multiple sclerosis: a prospective, randomized, open-label pilot trial.

    Science.gov (United States)

    Simsarian, James P; Saunders, Carol; Smith, D Michelle

    2011-01-01

    Despite over 50 years of experience with adrenocorticotropic hormone (ACTH) as a treatment for acute exacerbations of multiple sclerosis, there have been no trials examining the options of the 2-3-week dosing regimen or intramuscular injection protocol used in the original trials. At our clinic, we performed a small, prospective, randomized pilot study to examine the efficacy and safety of, and patient satisfaction with, a short (five-day) self-administered ACTH dosing protocol for exacerbations of multiple sclerosis, and to compare the subcutaneous and intramuscular routes of administration. Patients for this study were recruited from an outpatient treatment clinic. Each patient self-administered natural ACTH gel 80 U/day by subcutaneous or intramuscular injection for five consecutive days and was evaluated at baseline and on days 7 and 14. Patient feedback was collected using the Patient Global Impression of Change (PGI-C, the primary efficacy measure), a patient global visual analog scale, the Expanded Disability Status Scale, a timed walk, the Nine-hole Peg Test, and the Clinical Global Impression of Change. Of the 20 enrolled patients (mean age 39.5 years), 19 completed the study. On day 14, 61.1% of patients (11 of 18 with day 14 scores) were treatment responders, and rated their condition as "very much improved" or "much improved" on the PGI-C. The intramuscular group had numerically more responders, but there was no significant difference in the proportion of responders between the intramuscular and subcutaneous groups at day 14 (P = 0.3). The intramuscular route of injection was associated with more injection site pain than the subcutaneous route. A shorter five-day course of intramuscular or subcutaneous ACTH gel may improve symptoms associated with acute exacerbations of multiple sclerosis. Larger studies with standard of care controls are needed to confirm whether this shorter course of intramuscular or subcutaneous ACTH gel is effective and could

  13. Active Mycobacterium Infection Due to Intramuscular BCG Administration Following Multi-Steps Medication Errors

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    MohammadReza Rafati

    2015-10-01

    Full Text Available Bacillus Calmette-Guérin (BCG is indicated for treatment of primary or relapsing flat urothelial cell carcinoma in situ (CIS of the urinary bladder. Disseminated infectious complications occasionally occur due to BCG as a vaccine and intravesical therapy.  Intramuscular (IM or Intravenous (IV administrations of BCG are rare medication errors which are more probable to produce systemic infections. This report presents 13 years old case that several steps medication errors occurred consequently from physician handwriting, pharmacy dispensing, nursing administration and patient family. The physician wrote βHCG instead of HCG in the prescription. βHCG was read as BCG by the pharmacy staff and 6 vials of intravesical BCG were administered IM twice a week for 3 consecutive weeks. The patient experienced fever and chills after each injection, but he was admitted 2 months after first IM administration of BCG with fever and pancytopenia. Unfortunately four month after using drug, during second admission duo to cellulitis at the sites of BCG injection the physicians diagnosed the medication error. Using handwritten prescription and inappropriate abbreviations, spending inadequate time for taking a brief medical history in pharmacy, lack of verifying name, dose and wrote before medication administration and lack of considering medication error as an important differential diagnosis had roles to occur this multi-steps medication error.

  14. Pharmacokinetic-pharmacodynamic model to evaluate intramuscular tetracycline treatment protocols to prevent antimicrobial resistance in pigs.

    Science.gov (United States)

    Ahmad, Amais; Græsbøll, Kaare; Christiansen, Lasse Engbo; Toft, Nils; Matthews, Louise; Nielsen, Søren Saxmose

    2015-03-01

    High instances of antimicrobial resistance are linked to both routine and excessive antimicrobial use, but excessive or inappropriate use represents an unnecessary risk. The competitive growth advantages of resistant bacteria may be amplified by the strain dynamics; in particular, the extent to which resistant strains outcompete susceptible strains under antimicrobial pressure may depend not only on the antimicrobial treatment strategies but also on the epidemiological parameters, such as the composition of the bacterial strains in a pig. This study evaluated how variation in the dosing protocol for intramuscular administration of tetracycline and the composition of bacterial strains in a pig affect the level of resistance in the intestine of a pig. Predictions were generated by a mathematical model of competitive growth of Escherichia coli strains in pigs under specified plasma concentration profiles of tetracycline. All dosing regimens result in a clear growth advantage for resistant strains. Short treatment duration was found to be preferable, since it allowed less time for resistant strains to outcompete the susceptible ones. Dosing frequency appeared to be ineffective at reducing the resistance levels. The number of competing strains had no apparent effect on the resistance level during treatment, but possession of fewer strains reduced the time to reach equilibrium after the end of treatment. To sum up, epidemiological parameters may have more profound influence on growth dynamics than dosing regimens and should be considered when designing improved treatment protocols. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  15. Acceptability and intramuscular collagen properties of Podolian beef as affected by ageing

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    Giuseppe Maiorano

    2010-01-01

    Full Text Available The present study aimed to assess the effect of different ageing periods (2, 8, 15 and 21 d on intramuscular collagen (IMC properties, meat colour and water holding capacity (WHC and on meat liking in order to define the appropriate maturation length for Podolian meat. Longissimus dorsi lumborum from 6 Podolian young bulls, slaughtered at 14 months of age, was used. A total of 101 consumers participated in the test. Although not significantly, IMC concentration decreased after 15 d of ageing. Fibre collagen stability had a wavering trend, with an increase at 15 d (P<0.05 and a significant decrease at 21 d (P<0.05. Ageing time influenced colour parameters, with increased L* (P<0.01, a* (P<0.05 and b* (P<0.001. The degradation of myofibrils with muscle maturation decreased the percentage of thawing loss (P<0.01. The application of a prolonged ageing (15-21 d improved the overall liking (P<0.001 and the liking in terms of odour (P<0.001, taste/flavour (P<0.001 and texture (P<0.001. No significant differences were observed between 15 and 21 d of ageing for these parameters. We conclude that for Podolian meat the most appropriate ageing period may be 15 days.

  16. Maternal butyrate supplementation induces insulin resistance associated with enhanced intramuscular fat deposition in the offspring.

    Science.gov (United States)

    Huang, Yanping; Gao, Shixing; Chen, Jinglong; Albrecht, Elke; Zhao, Ruqian; Yang, Xiaojing

    2017-02-21

    Maternal nutrition is important for the risk of the offspring to develop insulin resistance and adiposity later in life. The study was undertaken to determine effects of maternal butyrate supplementation on lipid metabolism and insulin sensitivity in the offspring skeletal muscle. The offspring of rats, fed a control diet or a butyrate diet (1% sodium butyrate) throughout gestation and lactation, was studied at weaning and at 60 days of age. The offspring of dams fed a butyrate diet had higher HOMA-insulin resistance and impaired glucose tolerance. This was associated with elevated mRNA and protein expressions of lipogenic genes and decreased amounts of lipolytic enzyme. Simultaneously, enhanced acetylation of histone H3 lysine 9 and histone H3 lysine 27 modification on the lipogenic genes in skeletal muscle of adult offspring was observed. Higher concentration of serum insulin and intramuscular triglyceride in skeletal muscle of offspring from the butyrate group at weaning were accompanied by increasing levels of lipogenic genes and enrichment of acetylation of histone H3 lysine 27. Maternal butyrate supplementation leads to insulin resistance and ectopic lipid accumulation in skeletal muscle of offspring, indicating the importance of short chain fatty acids in the maternal diet on lipid metabolism.

  17. Nonnutritive sucking and oral sucrose relieve neonatal pain during intramuscular injection of hepatitis vaccine.

    Science.gov (United States)

    Liaw, Jen-Jiuan; Zeng, Wen-Ping; Yang, Luke; Yuh, Yeong-Seng; Yin, Ti; Yang, Meei-Horng

    2011-12-01

    Newborns are subject to pain during routine invasive procedures. Pain caused by immunization injections is preventable, but remains untreated in neonates. The purpose of the study was to compare the effectiveness of three nonpharmacological pain relief strategies on newborns' pain, physiological parameters, and cry duration before, during, and after hepatitis B intramuscular (IM) injection. In this prospective, randomized clinical trial, we enrolled 165 newborns (gestational age, ≥36 weeks). The infants received IM injections and were randomized to three treatment groups: nonnutritive sucking (NNS), 20% oral sucrose, or routine care. Pain was measured by the Neonatal Facial Coding System, physiological signals by electrocardiogram monitors, and cry duration using a stopwatch. Pain was significantly lower among infants in the NNS (B=-11.27, Pinjection. Sucrose orally administered two minutes before injection more effectively reduced newborns' pain during injection than NNS. Both nonpharmacological methods more effectively relieved newborns' pain, stabilized physiological parameters, and shortened cry duration during IM hepatitis injection than routine care. Copyright © 2011 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved.

  18. Intramuscular pressure and electromyography as indexes of force during isokinetic exercise

    Science.gov (United States)

    Aratow, M.; Ballard, R. E.; Grenshaw, A. G.; Styf, J.; Watenpaugh, D. E.; Kahan, N. J.; Hargens, A. R.

    1993-01-01

    A direct method for measuring force production of specific muscles during dynamic exercise is presently unavailable. Previous studies indicate that both intramuscular pressure (IMP) and electromyography (EMG) correlate linearly with muscle contraction force during isometric exercise. The objective of this study was to compare IMP and EMG as linear assessors of muscle contraction force during dynamic exercise. IMP and surface EMG activity were recorded during concentric and eccentric isokinetic plantarflexion and dorsiflexion of the ankle joint from the tibialis anterior (TA) and soleus (SOL) muscles of nine male volunteers. Ankle torque was measured using a dynamometer, and IMP was measured via catheterization. IMP exhibited better linear correlation than EMG with ankle joint torque during concentric contractions of the SOL and the TA, as well as during eccentric contractions. IMP provides a better index of muscle contraction force than EMG during concentric and eccentric exercise through the entire range of torque. IMP reflects intrinsic mechanical properties of individual muscles, such as length-tension relationships, which EMG is unable to assess.

  19. Pharmacokinetics of amoxicillin trihydrate in male Asian elephants (Elephas maximus) following intramuscular administration.

    Science.gov (United States)

    Sinphithakkul, P; Klangkaew, N; Sanyathitiseree, P; Giorgi, M; Kumagai, S; Poapolathep, A; Poapolathep, S

    2016-06-01

    The purpose of this study was to investigate the pharmacokinetic characteristics of amoxicillin (AMX) trihydrate in male Asian elephants, Elephas maximus, following intramuscular administration at two dosages of 5.5 and 11 mg/kg body weight (b.w.). Blood samples were collected from 0.5 up to 72 h. The concentration of AMX in elephant plasma was measured using liquid chromatography electrospray ionization mass spectrometry. AMX was measurable up to 24 h after administration at two dosages. Peak plasma concentration (Cmax ) was 1.20 ± 0.39 μg/mL after i.m. administration at a dosage of 5.5 mg/kg b.w., whereas it was 3.40 ± 0.63 μg/mL at a dosage of 11 mg/kg b.w. A noncompartment model was developed to describe the disposition of AMX in Asian elephants. Based on the preliminary findings found in this research, the dosage of 5.5 and 11 mg/kg b.w. produced drug plasma concentrations higher than 0.25 mg/mL for 24 h after i.m. administration. Thereafter, i.m. administration with AMX at a dosage of 5.5 mg/kg b.w. appeared a more suitable dose than 11 mg/kg b.w. However, more studies are needed to determine AMX clinical effectiveness in elephants. © 2015 John Wiley & Sons Ltd.

  20. Comparison of Intramuscular or Subcutaneous Injections vs. Castration in Pigs—Impacts on Behavior and Welfare

    Directory of Open Access Journals (Sweden)

    John McGlone

    2016-08-01

    Full Text Available Physical castration (PC is painful and stressful for nursing piglets. One alternative to PC is immunological castration (IC, but the pain and stress of handling associated with injections have not been assessed. The objectives of this study were to measure the pain and distress of subcutaneous (SQ and intramuscular (IM injections compared to PC in piglets, and to compare SQ or IM injections in finishing pigs. After farrowing, 3 to 5 d old male piglets were randomly assigned to (control no handling treatment (NO, sham-handling (SHAM, IM, SQ, or PC. Finishing pigs were assigned to NO, SHAM, IM, or SQ. Behavior was monitored for 1 h prior and 1 h post treatment in each age group. Social, feeding behaviors, and signs of pain were recorded. Finishing pigs treated with SQ injections had higher feeding behaviors pre-treatment than they did post-treatment. Overall, physical castrations caused measurable pain-like behaviors and general behavioral dysregulation at a much higher level than the other treatment groups. SQ and IM injections did not cause either significant behavioral or physiological alterations in piglets. SQ injections caused a decrease in finishing pig feed behaviors post treatment ( p = 0.02 and SHAM treated finishing pigs spent significantly more time lying than the other treatment groups. In general IM and SQ injections did not cause any other significant changes in behavior or physiology.

  1. Intramuscular pressures in antigravity muscles using gravity-independent, pneumatic hardware.

    Science.gov (United States)

    Macias, Brandon R; Minocha, Ranjeet; Cutuk, Adnan A; Hill, James; Shiau, Jonathon; Hargens, Alan R

    2008-08-01

    Resistive exercise helps prevent muscle atrophy in microgravity, but better exercise equipment is needed. Therefore, the purpose of this study was to determine if a pneumatic, gravity-independent leg-press device (LPD) provides sufficient force to leg musculature. We hypothesized that intramuscular pressure (IMP), a quantitative index of muscle force, is greater in the antigravity superficial posterior and deep posterior compartments than in the non-antigravity anterior compartment during bilateral leg-press exercise. Millar pressure transducers were inserted into the anterior, lateral, superficial posterior, and deep posterior muscle compartments of the left leg of eight healthy subjects (three women, five men). Subjects were supine on the Keiser SX-1, a pneumatic LPD. Then maximal voluntary contraction (MVC) was determined; each subject performed three consecutive voluntary contractions at approximately 18%, 50%, and 100% MVC while continuously measuring IMP. Repeated measures ANOVA were used to determine differences of IMPs between compartments and loads. The magnitudes of IMP (mean +/- SEM) at 18 - 3% (abbreviated approximately 18%), 50%, and 100% MVC in the superficial and deep posterior compartments were significantly greater than that in the anterior compartment during exercise (P muscles of the leg are contained primarily in the superficial and deep posterior compartments, the LPD may help prevent muscle atrophy associated with microgravity.

  2. Intramuscular anti-D in chronic immune thrombocytopenia children with severe thrombocytopenia.

    Science.gov (United States)

    Sirachainan, Nongnuch; Anurathapan, Usanarat; Chuansumrit, Ampaiwan; Songdej, Duantida; Wongwerawattanakoon, Pakawan; Hutspardol, Sakara; Kitpoka, Pimpun

    2013-12-01

    Nine patients with chronic immune thrombocytopenia and platelet counts anti-D. Phase 1 was anti-D daily for 5 days, followed by phase 2, anti-D weekly for 12 weeks and withheld when platelet counts ≥ 20 × 10(9) /L, and then phase 3 was anti-D once every 2 weeks for 24 weeks. According to the International Working Group criteria, in phase 1, 66.7% of patients responded to the treatment. In phases 2 and 3, 11.1% (0-41.7%) and 7.7% (0-33.3%) of total episodes of follow up, respectively, responded to the treatment. Therefore, intramuscular anti-D given at a dose of 10 mcg/kg for 5 days is an alternative method to raise platelet counts in chronic immune thrombocytopenia children with severe thrombocytopenia where the intravenous form of anti-D is not available. © 2013 The Authors. Pediatrics International © 2013 Japan Pediatric Society.

  3. Sedative, cardiovascular, haematologic and biochemical effects of four different drug combinations administered intramuscularly in cats.

    Science.gov (United States)

    Biermann, Kirsten; Hungerbühler, Stephan; Mischke, Reinhard; Kästner, Sabine B R

    2012-03-01

    To compare effects of four drug combinations on sedation, echocardiographic, haematologic and biochemical variables and recovery in cats. Experimental randomized 'blinded' cross-over study. Six healthy cats. Treatments were administered intramuscularly: midazolam 0.4 mg kg(-1) and butorphanol 0.4 mg kg(-1) (MB); midazolam 0.4 mg kg(-1), butorphanol 0.4 mg kg(-1) and ketamine 3 mg kg(-1) (MBK); midazolam 0.4 mg kg(-1), butorphanol 0.4 mg kg(-1) and dexmedetomidine 5 μg kg(-1) (MBD); ketamine 3 mg kg(-1) and dexmedetomidine 5 μg kg(-1) (KD). Sedation was evaluated at time-points over 10 minutes post injection. Echocardiography, systolic arterial blood pressure (SAP) measurement and blood sampling were performed at baseline and from 10 minutes after treatment. Quality of recovery was scored. Data were analysed by anova for repeated measures. p measurements, treatments decreased SAP by 17%, 25%, 13%, 5% in MB, MBK, MBD and KD, respectively. Heart rate decreased (p glucose was increased after MBD (31%) and KD (52%) and lactate concentration was decreased (p cats. Treatment MBK led to acceptable sedation and minimal cardiovascular changes. Both treatments with dexmedetomidine produced excellent sedation and recovery but induced more cardiovascular depression and haematologic changes. © 2012 The Authors. Veterinary Anaesthesia and Analgesia. © 2012 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesiologists.

  4. Tissue damage caused by the intramuscular injection of long-acting penicillin.

    Science.gov (United States)

    Schanzer, H; Jacobson, J H

    1985-04-01

    In order to elucidate whether tissue damage produced on occasion by intramuscular injection of long-acting penicillin is due to accidental intra-arterial injection or vasospasm, two types of experiments were carried out in rabbits. In the first set of experiments, six New Zealand White rabbits were given intra-arterial injections of 0.4 mL of a mixture containing 300,000 U of penicillin G benzathine and 300,000 units of penicillin procaine per milliliter (Bicillin C-R) into the left femoral artery and 0.4 mL of normal saline into the right femoral artery as autocontrol. In a second set of experiments, 0.4 mL of the same penicillin preparation was injected in the space surrounding the left femoral artery in five New Zealand rabbits, and 0.4 mL of normal saline was injected in a similar fashion around the right femoral artery as control. The legs of the rabbits that received the intra-arterial injection of penicillin invariably developed ischemic manifestations. None of the legs of rabbits given intra-arterial injections of normal saline had pathologic manifestations. None of the rabbits that received the periarterial penicillin preparation or normal saline developed abnormalities. These results strongly suggest that the tissue damage produced by penicillin is secondary to the intra-arterial administration of the drug.

  5. First reported experience with intramuscular diaphragm pacing in replacing positive pressure mechanical ventilators in children.

    Science.gov (United States)

    Onders, Raymond P; Ponsky, Todd A; Elmo, MaryJo; Lidsky, Karen; Barksdale, Edward

    2011-01-01

    Diaphragm pacing (DP) has been shown to successfully replace mechanical ventilators for adult tetraplegic patients with chronic respiratory insufficiency. This is the first report of DP in ventilator-dependent children. This was a prospective interventional experience under institutional review board approval. Diaphragm pacing involves outpatient laparoscopic diaphragm motor point mapping to identify the site where stimulation causes maximum diaphragm contraction with implantation of 4 percutaneous intramuscular electrodes. Diaphragm conditioning ensues to wean the child from the ventilator. Six children were successfully implanted ranging from 5 to 17 years old with the smallest 15 kg in weight. Length of time on mechanical ventilation ranged from 11 days to 7.6 years with an average of 3.2 years. In all patients, DP provided tidal volumes above basal needs. Five of the patients underwent a home-based weaning program, whereas one patient who was implanted only 11 days post spinal cord injury never returned to the ventilator with DP use. Another patient was weaned from the ventilator full time but died of complications of his underlying brain stem tumor. The remaining patients weaned from the ventilator for over 14 hours a day and/or are actively conditioning their diaphragms. Diaphragm pacing successfully replaced mechanical ventilators, which improves quality of life. Copyright © 2011 Elsevier Inc. All rights reserved.

  6. Postoperative analgesic effects of intravenous, intramuscular, subcutaneous or oral transmucosal buprenorphine administered to cats undergoing ovariohysterectomy.

    Science.gov (United States)

    Giordano, Tatiana; Steagall, Paulo V M; Ferreira, Tatiana H; Minto, Bruno W; de Sá Lorena, Sílvia Elaine Rodolfo; Brondani, Juliana; Luna, Stelio P L

    2010-07-01

    To compare the postoperative analgesic effects of intravenous (IV), intramuscular (IM), subcutaneous (SC) or oral transmucosal (OTM) buprenorphine administered to cats undergoing ovariohysterectomy. Randomized, prospective and blinded clinical trial. 100 female cats. Cats were assigned to receive 0.01 mg kg(-1) of buprenorphine administered by the IV, IM, SC or OTM route (n = 25/group). Buprenorphine was made up to 0.3 mL with 0.9% saline. DIVAS (0-100 mm) and simple descriptive scale (SDS) (from 0 to 4) pain and sedation scores were assigned to each cat before and 1, 2, 3, 4, 6, 8, 12 and 24 hours after ovariohysterectomy. Buprenorphine and carprofen were administered for rescue analgesia. Data were analyzed using anova and Fisher's exact test (p 0.05). There were no significant differences between groups for sedation scores at any time. SDS pain scores did not detect any differences between groups (p > 0.05). DIVAS pain scores after OTM administration were significantly higher than IV and IM administration at 1 hour and at 3, 4, 6, 8 and 12 hours, respectively (p buprenorphine required rescue analgesia, respectively. There was a significantly higher incidence of treatment failure in cats that received SC and OTM buprenorphine compared with cats that received IV and IM buprenorphine (p buprenorphine provided better postoperative analgesia than SC or OTM administration of the drug and these routes of administration should be preferred when buprenorphine is administered to cats.

  7. Lower aerobic capacity was associated with abnormal intramuscular energetics in patients with metabolic syndrome

    International Nuclear Information System (INIS)

    Yokota, Takashi; Kinugawa, Shintaro; Okita, Koichi

    2011-01-01

    Lower aerobic capacity is a strong and independent predictor of cardiovascular morbidity and mortality in patients with metabolic syndrome (MetS). However, the mechanisms are not fully elucidated. We tested the hypothesis that skeletal muscle dysfunction could contribute to the lower aerobic capacity in MetS patients. The incremental exercise tests with cycle ergometer were performed in 12 male patients with MetS with no habitual exercise and 11 age-, sex- and activity-matched control subjects to assess the aerobic capacity. We performed 31 phosphorus-magnetic resonance spectroscopy (MRS) to assess the high-energy phosphate metabolism in skeletal muscle during aerobic exercise. Proton-MRS was also performed to measure intramyocellular lipid (IMCL) content. Peak oxygen uptake (peak VO 2 ; 34.1±6.2 vs. 41.4±8.4 ml kg -1 min -1 , P -1 min -1 , P 2 (r=-0.64) and AT (r=-0.60), respectively. IMCL content was threefold higher in MetS and was inversely correlated with peak VO 2 (r=-0.47) and AT (r=-0.52), respectively. Moreover, there was a positive correlation between IMCL content and PCr loss (r=0.64). These results suggested that lean-body aerobic capacity in MetS patients was lower compared with activity-matched healthy subjects, which might be due to the reduced intramuscular fatty acid oxidative metabolism. (author)

  8. Muscle and genotype effects on fatty acid composition of goat kid intramuscular fat

    Directory of Open Access Journals (Sweden)

    Valeriano Domenech

    2011-07-01

    Full Text Available Little is known about the fatty acid composition of the major muscles in goats from different breeds. Forty entire male suckling kids, 20 Criollo Cordobes and 20 Anglo Nubian, were slaughtered at 75 days of age and the fatty acid composition of their longissimus thoracis (LT and semitendinosus (ST muscles was analysed to clarify the effects of genotype and muscle type on goat kid meat. Genotype had a great influence on the fatty acid composition of goat kid meat. Meat from Criollo Cordobes had greater saturated (P<0.001 and lower monounsaturated (P<0.001 and polyunsaturated fatty acids (P=0.002 concentration than meat from Anglo Nubian, showing higher saturated fatty acids (SFA. On the other hand, intramuscular fat content from both genotypes was higher (P=0.042 in ST muscle, while the lowest cholesterol levels were observed in ST of Criollo Cordobes (P=0.038. That higher fat content resulted in lower relative contents of total polyunsaturated (P<0.001 and n-3 (P=0.002 fatty acids due to the lower contribution of the membrane phospholipids.

  9. Accessing the biocompatibility of layered double hydroxide by intramuscular implantation: histological and microcirculation evaluation.

    Science.gov (United States)

    Cunha, Vanessa Roberta Rodrigues; de Souza, Rodrigo Barbosa; da Fonseca Martins, Ana Maria Cristina Rebello Pinto; Koh, Ivan Hong Jun; Constantino, Vera Regina Leopoldo

    2016-08-02

    Biocompatibility of layered double hydroxides (LDHs), also known as hydrotalcite-like materials or double metal hydroxides, was investigated by in vivo assays via intramuscular tablets implantation in rat abdominal wall. The tablets were composed by chloride ions intercalated into LDH of magnesium/aluminum (Mg2Al-Cl) and zinc/aluminum (Zn2Al-Cl). The antigenicity and tissue integration capacity of LDHs were assessed histologically after 7 and 28 days post-implantation. No fibrous capsule nearby the LDH was noticed for both materials as well any sign of inflammatory reactions. Sidestream Dark Field imaging, used to monitor in real time the microcirculation in tissues, revealed overall integrity of the microcirculatory network neighboring the tablets, with no blood flow obstruction, bleeding and/or increasing of leukocyte endothelial adhesion. After 28 days Mg2Al-Cl promoted multiple collagen invaginations (mostly collagen type-I) among its fragments while Zn2Al-Cl induced predominantly collagen type-III. This work supports previous results in the literature about LDHs compatibility with living matter, endorsing them as functional materials for biomedical applications.

  10. Intramuscular adipose tissue determined by T1-weighted MRI at 3T primarily reflects extramyocellular lipids.

    Science.gov (United States)

    Akima, Hiroshi; Hioki, Maya; Yoshiko, Akito; Koike, Teruhiko; Sakakibara, Hisataka; Takahashi, Hideyuki; Oshida, Yoshiharu

    2016-05-01

    The purpose of this study was to assess relationships between intramuscular adipose tissue (IntraMAT) content determined by MRI and intramyocellular lipids (IMCL) and extramyocellular lipids (EMCL) determined by (1)H magnetic resonance spectroscopy ((1)H MRS) or echo intensity determined by B-mode ultrasonography of human skeletal muscles. Thirty young and elderly men and women were included. T1-weighted MRI was taken from the right mid-thigh to measure IntraMAT content of the vastus lateralis (VL) and biceps femoris (BF) using a histogram shape-based thresholding technique. IMCL and EMCL were measured from the VL and BF at the right mid-thigh using (1)H MRS. Ultrasonographic images were taken from the VL and BF of the right mid-thigh to measure echo intensity based on gray-scale level for quantitative analysis. There was a significant correlation between IntraMAT content by MRI and EMCL of the VL and BF (VL, r=0.506, Plipids, not intramyocellular lipids, in human skeletal muscles. Copyright © 2016 Elsevier Inc. All rights reserved.

  11. Pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin after intramuscular administration of enrofloxacin in goats.

    Science.gov (United States)

    Rao, G S; Ramesh, S; Ahmad, A H; Tripathi, H C; Sharma, L D; Malik, J K

    2001-04-01

    The pharmacokinetics of enrofloxacin and its active metabolite ciprofloxacin were investigated in goats after a single intramuscular administration of enrofloxacin at 2.5 mg/kg body weight. The plasma concentrations of enrofloxacin and ciprofloxacin were determined simultaneously by a HPLC method. The peak concentrations (Cmax) of enrofloxacin (1.13 microg/ml) and ciprofloxacin (0.24 microg/ml) were observed at 0.8 and 1.2 h, respectively. The elimination half-life (t1/2beta), volume of distribution (Vd(area)), total body clearance (Cl(B)) and mean residence time (MRT) of enrofloxacin were 0.74 h, 1.42 L/kg, 1329 ml/h per kg and 1.54 h, respectively. The t1/2beta, area under the plasma concentration-time curve (AUC) and the MRT of ciprofloxacin were 1.38 h, 0.74 microg h/ml and 2.73 h, respectively. The metabolic conversion of enrofloxacin to ciprofloxacin was appreciable (36%) and the sum of the plasma concentrations of enrofloxacin and ciprofloxacin was maintained at or above 0.1 microg/ml for up to 4 h. Enrofloxacin appears to be useful for the treatment of goat diseases associated with pathogens sensitive to this drug.

  12. Noninvasive Monitoring of Elevated Intramuscular Pressure in a Model Compartment Syndrome via Quantitative Fascial Motion

    Science.gov (United States)

    Lynch, John E.; Lynch, John K.; Cole, Steven L.; Carter, Jonathan A.; Hargens, Alan R.

    2009-01-01

    Compartment syndromes, caused by elevated intramuscular pressure (IMP) and resulting from trauma or chronic overuse, frequently require invasive IMP monitoring for accurate diagnosis. Our objective is to test a non-invasive ultrasound technique for estimating IMP based on fascial displacement waveforms from arterial blood pressure pulses. In this study, IMP was increased in the legs of 23 healthy adult subjects up to 80 mmHg using two blood pressure cuffs covering the region from the knee to the ankle. Receiver operator characteristic (ROC) curves and recursive partitioning were used to determine the sensitivity and specificity of diagnosing elevated IMP using fascial displacement. For one ROC curve, in which several ultrasonic measurement parameters were used along with subject body mass index and blood pressure, the sensitivity and specificity for diagnosing normal IMP (below 30 mmHg) from elevated IMP (30 mmHg and up) was 0.61 and 0.94 respectively. Recursive partitioning, in which IMP was divided into three ranges (normal = 50 mmHg), resulted in improved diagnostic sensitivity (0.77) with almost no change in specificity (0.93). PMID:18979529

  13. An interlaboratory study of the pharmacokinetics of testosterone following intramuscular administration to Thoroughbred horses.

    Science.gov (United States)

    Moeller, B C; Sams, R A; Guinjab-Cagmat, J; Szabo, N J; Colahan, P; Stanley, S D

    2011-12-01

    Testosterone is an anabolic androgenic steroid (AAS) that is endogenously produced by both male and female horses that also has the potential for abuse when administered exogenously to race horses. To recommend appropriate withdrawal guidelines so that veterinarians can discontinue therapeutic use prior to competition, the pharmacokinetics and elimination of testosterone were investigated. An aqueous testosterone suspension was administered intramuscularly in the neck of Thoroughbred horses (n = 20). The disposition of testosterone from this formulation was characterized by an initial, rapid absorption phase followed by a much more variable secondary absorption phase. The median terminal half-life was 39 h. A second focus of this study was to compare the testosterone concentrations determined by two different laboratories using a percentage similarity model with a coefficient of variation of 16.5% showing good agreement between the two laboratories results. Based on the results of this study, a withdrawal period of 30 days for aqueous testosterone administered IM is recommended. © 2011 Blackwell Publishing Ltd.

  14. Streptococcus bovis/S. equinus complex septicemia in a group of calves following intramuscular vaccination.

    Science.gov (United States)

    Clarke, Lorelei L; Fathke, Robert L; Sanchez, Susan; Stanton, James B

    2016-07-01

    Organisms previously classified as Streptococcus bovis (i.e., the S. bovis/S. equinus complex) are common in cattle feces, but may also act as opportunistic pathogens. In the current work, Streptococcus infantarius subsp. coli, a member of this complex, was associated of a cluster of calves that died within hours of injection with a modified live viral vaccine. Within 12 h of vaccination of 46 calves at a cow/calf operation, 4 calves had died, 3 calves were ill, and 1 unvaccinated cow was dead. Autopsies were performed on the cow, 2 dead calves, and 1 affected surviving calf, which was euthanized ~24 h after vaccine administration. The animals had similar gross anatomic and microscopic lesions, including subcutaneous and intramuscular dark hemorrhage on the caudal neck, multiorgan ecchymosis and petechiation, and alveolitis to interstitial pneumonia. Gram-positive cocci were in the vasculature of the lung and skeletal muscle, and S. infantarius subsp. coli was cultured from tissues and from the vaccines used on affected animals, but not in vials used on unaffected animals. Together, these findings suggest death caused by streptococcal septicemia and toxemia as a result of contamination. © 2016 The Author(s).

  15. INTRAMUSCULAR TEMPERATURE DIFFERENCES BETWEEN THE MID-POINT AND PERIPHERAL EFFECTIVE RADIATING AREA WITH ULTRASOUND

    Directory of Open Access Journals (Sweden)

    Michale G. Miller

    2008-06-01

    Full Text Available The purpose of the study was to determine whether uniform intramuscular heating is achieved throughout a treatment area 2 times the transducer head at both 1 and 3 MHz. Seven male and three female subjects (Age: 23.6 ± 1.0 yrs, Weight: 83.8 ± 23.2 kg, Site Skinfold: 13.9 ± 7.3 mm underwent two ultrasound treatments (1 and 3 MHz in the triceps surae muscle group. Thermocouples were inserted at the midpoint and periphery of the treatment area. Ten minute baseline temperatures were recorded followed by a ten minute ultrasound treatment. Two (site X 10 (time repeated measures ANOVAs were separately used to determine significance for 1 and 3 MHz treatments. Post-hoc testing was performed using the Bonferroni adjustment. A significant site-by-time interaction was observed for both the 1 and 3 MHz treatments. From baseline to the end of the treatment, temperature increased approximately 2.62°C and 1.58°C for the midpoint and periphery of the 1 MHz treatment and 5.88°C and 3.64°C for the 3 MHz treatment. The differences in temperature suggest that uniform heating does not occur throughout the treatment area

  16. The pharmacokinetics of midazolam after intravenous, intramuscular, and rectal administration in healthy dogs.

    Science.gov (United States)

    Schwartz, M; Muñana, K R; Nettifee-Osborne, J A; Messenger, K M; Papich, M G

    2013-10-01

    Intravenous benzodiazepines are utilized as first-line drugs to treat prolonged epileptic seizures in dogs and alternative routes of administration are required when venous access is limited. This study compared the pharmacokinetics of midazolam after intravenous (IV), intramuscular (IM), and rectal (PR) administration. Six healthy dogs were administered 0.2 mg/kg midazolam IV, IM, or PR in a randomized, 3-way crossover design with a 3-day washout between study periods. Blood samples were collected at baseline and at predetermined intervals until 480 min after administration. Plasma midazolam concentrations were measured by high-pressure liquid chromatography with UV detection. Rectal administration resulted in erratic systemic availability with undetectable to low plasma concentrations. Arithmetic mean values ± SD for midazolam peak plasma concentrations were 0.86 ± 0.36 μg/mL (C0) and 0.20 ± 0.06 μg/mL (Cmax), following IV and IM administration, respectively. Time to peak concentration (Tmax ) after IM administration was 7.8 ± 2.4 min with a bioavailability of 50 ± 16%. Findings suggest that IM midazolam might be useful in treating seizures in dogs when venous access is unavailable, but higher doses may be needed to account for intermediate bioavailability. Rectal administration is likely of limited efficacy for treating seizures in dogs. © 2012 John Wiley & Sons Ltd.

  17. Intramuscular injections: a review of best practice for mental health nurses.

    Science.gov (United States)

    Cocoman, A; Murray, J

    2008-06-01

    This paper reviews practice in the area of intramuscular (IM) injection administration, an everyday activity for many nurses in clinical practice. The authors address administration of neuroleptic depot drugs within the adult mental health environment and examine the evidence base for this practice. A historical overview of injection practices and use of the dorsogluteal site is given, followed by more contemporary evidence on the benefits of using the ventrogluteal, deltoid and thigh sites. The authors point out that despite being a very commonplace nursing activity, there is a dearth of research-based guidelines for nurses in this area. A quantity of published papers and nursing texts on injection sites and techniques were assessed to evaluate their quality and relevance and their overall benefit to improving clinical practice. Much of the literature available was in the form of opinion pieces without a sound research/evidence base. There appears, however, to be enough consensual evidence to form an evidence-based clinical guideline for the administration of IM injections. The review of the available evidence, albeit at times contradictory, is presented along with a discussion of the implications for nurses.

  18. The safety and acceptability of intravenous fentanyl versus intramuscular pethidine for pain relief during labour.

    Science.gov (United States)

    Rezk, M; El-Shamy, E S; Massod, A; Dawood, R; Habeeb, R

    2015-01-01

    This trial aimed to ascertain the relative efficacy, adverse effects, and acceptability of fentanyl versus pethidine for pain relief during labour. Parturients (n=80) in the active phase who requested analgesia were randomly assigned to receive either intravenous fentanyl (n=40) or intramuscular pethidine (n=40). Pain scores hourly, maternal and fetal adverse effects, neonatal outcome, and maternal acceptability were assessed. Pain scores decreased in both groups, the decrease varying from mild to moderate, average pain scores remaining above 3.5 in both groups. Pain scores returned towards baseline over time; three hours after the initiation of treatment in the fentanyl group. Pethidine was associated with more maternal nausea and vomiting (p administration when compared to pethidine (p drugs were acceptable for pain relief during labour. Fentanyl is comparable to pethidine for pain relief during labour regarding efficacy and acceptability, but with more neonates with low Apgar scores at one minute and higher need for neonatal resuscitation and naloxone administration. Further larger trials are needed to confirm its safety.

  19. Pharmacokinetics of the novel atypical opioid tapentadol after intravenous, intramuscular and subcutaneous administration in cats.

    Science.gov (United States)

    Lee, H-K; Lebkowska-Wieruszewska, B; Kim, T-W; Kowaski, C-J; Giorgi, M

    2013-12-01

    Drugs that provide effective analgesia in cats are limited. The aim of the present study was to investigate the pharmacokinetics of the novel atypical drug tapentadol (TAP) after intravenous (IV), intramuscular (IM) and subcutaneous (SC) injection in six healthy cats using a 3 × 3 Latin square crossover study design. The dose rate used was 5mg/kg and the concentrations of TAP in plasma were evaluated using high-performance liquid chromatography. Some adverse effects including salivation, agitation and panting, were noted, especially following IV administration. In all three administration groups, TAP concentrations were detectable in plasma for up to 8h. Bioavailability for each route was almost complete, accounting for 94% and 90% after IM and SC administrations, respectively. Drug absorption was faster after IM than SC administration (0.25 h vs. 0.63 h). The half-life of the terminal portion of the plasma concentration curve was not significantly different between the three routes of administrations (2-3h). TAP appears to have some variation in its pharmacokinetic features in cats compared to other animal species. Further studies are needed to evaluate whether TAP would be suitable for use in cats that are experiencing moderate to severe pain, but are sensitive to the adverse effects of commonly prescribed opioids. Copyright © 2013 Elsevier Ltd. All rights reserved.

  20. A 12-week subchronic intramuscular toxicity study of risperidone-loaded microspheres in rats.

    Science.gov (United States)

    Zhang, J; Ye, L; Wang, W; Du, G; Yu, X; Zhu, X; Dong, Q; Cen, X; Guan, X; Fu, F; Tian, J

    2015-02-01

    Long-acting injectable formulations of antipsychotics have been an important treatment option to increase the compliance of the patient with schizophrenia by monitoring drug administration and identifying medication noncompliance and to improve the long-term management of schizophrenia. Risperidone, a serotoninergic 5-HT2 and dopaminergic D2 receptor antagonist, was developed to be a long-acting sustained-release formulation for the treatment of schizophrenia. In this study, 12-week subchronic toxicity study of risperidone-loaded microspheres (RMs) in rats by intramuscular injection with an 8-week recovery phase was carried out to investigate the potential subchronic toxicity of a novel long-acting sustained-release formulation. The results indicated that the dosage of 10-90 mg/kg of RM for 2 weeks did not cause treatment-related mortality. The main drug-related findings were contributed to the dopamine D2 receptor and α1-adrenoceptor antagonism of risperidone such as elevation of serum and pituitary prolactin levels and ptosis and changes in reproductive system (uterus, ovary, vagina, mammary gland, testis, seminal vesicle, epididymis, and prostate). In addition, foreign body granuloma in muscle at injection sites caused by poly-lactide-co-glycolide was observed. At the end of the recovery phase, these changes mostly returned to normal. The results indicated that RM had a good safety profile in rats. © The Author(s) 2015.

  1. The comprehensive liver transcriptome of two cattle breeds with different intramuscular fat content.

    Science.gov (United States)

    Wang, Xi; Zhang, Yuanqing; Zhang, Xizhong; Wang, Dongcai; Jin, Guang; Li, Bo; Xu, Fang; Cheng, Jing; Zhang, Feng; Wu, Sujun; Rui, Su; He, Jiang; Zhang, Ronghua; Liu, Wenzhong

    2017-08-26

    Intramuscular fat (IMF) content is an important determinant factor of meat quality in cattle. There is significant difference in IMF content between Jinnan and Simmental cattle. Here, to identify candidate genes and networks associated with IMF deposition, we deeply explored the transcriptome architecture of liver in these two cattle breeds. We sequenced the liver transcriptome of five Jinnan and three Simmental cattle, yielding about 413.9 million sequencing reads. 124 differentially expressed genes (DEGs) were detected, of which 53 were up-regulated and 71 were down-regulated in Jinnan cattle. 1282 potentially novel genes were also identified. Gene ontology analysis revealed these DEGs (including CYP21A2, PC, ACACB, APOA1, and FADS2) were significantly enriched in lipid biosynthetic process, regulation of cholesterol esterification, reverse cholesterol transport, and regulation of lipoprotein lipase activity. Genes involved in pyruvate metabolism pathway were also significantly overrepresented. Moreover, we identified an interaction network which related to lipid metabolism, which might be contributed to the IMF deposition in cattle. We concluded that the DEGs involved in the regulation of lipid metabolism could play an important role in IMF deposition. Overall, we proposed a new panel of candidate genes and interaction networks that can be associated with IMF deposition and used as biomarkers in cattle breeding. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. A Key Gene, PLIN1, Can Affect Porcine Intramuscular Fat Content Based on Transcriptome Analysis

    Directory of Open Access Journals (Sweden)

    Bojiang Li

    2018-04-01

    Full Text Available Intramuscular fat (IMF content is an important indicator for meat quality evaluation. However, the key genes and molecular regulatory mechanisms affecting IMF deposition remain unclear. In the present study, we identified 75 differentially expressed genes (DEGs between the higher (H and lower (L IMF content of pigs using transcriptome analysis, of which 27 were upregulated and 48 were downregulated. Notably, Kyoto Encyclopedia of Genes and Genomes (KEGG enrichment analysis indicated that the DEG perilipin-1 (PLIN1 was significantly enriched in the fat metabolism-related peroxisome proliferator-activated receptor (PPAR signaling pathway. Furthermore, we determined the expression patterns and functional role of porcine PLIN1. Our results indicate that PLIN1 was highly expressed in porcine adipose tissue, and its expression level was significantly higher in the H IMF content group when compared with the L IMF content group, and expression was increased during adipocyte differentiation. Additionally, our results confirm that PLIN1 knockdown decreases the triglyceride (TG level and lipid droplet (LD size in porcine adipocytes. Overall, our data identify novel candidate genes affecting IMF content and provide new insight into PLIN1 in porcine IMF deposition and adipocyte differentiation.

  3. Rats and rabbits as pharmacokinetic screening tools for long acting intramuscular depots: Case study with paliperidone palmitate suspension.

    Science.gov (United States)

    Patel, Harilal; Patel, Prakash; Modi, Nirav; Patel, Pinakin; Wagh, Yogesh; George, Alex; Desai, Nirmal; Srinivas, Nuggehally R

    2018-04-12

    1. Development of prodrug of paliperidone (9-hydroxyrisperidone) long-acting intramuscular injection has enabled delivery over 4-week time period with improved compliance. 2. Key aim of work was to establish a reliable preclinical model which may potentially serve as a screening tool for judging the pharmacokinetics of paliperidone formulation(s) prior to human clinical work. 3. Sparse sampling composite study was used in rats, (Wistar/Sprague-Dawley (n = 10)). A serial blood sampling study design was used in rabbits (n = 4). Animals received intramuscular injection of paliperidone palmitate in the thigh muscle at dose of 16 (rats) and 4.5 mg/kg (rabbits). Samples were drawn in rats (retro-orbital sinus) and rabbits (central ear artery) and analysed for paliperidone using LC-MS/MS assay. The plasma data was subjected to pharmacokinetic analysis. 4. Following intramuscular injection of depot formulation in Wistar/SD rats and rabbits, absorption of paliperidone was slow and gradual with median value of T max occurring on day 7. The exposures (i.e., AUC (0-28) days) were 18597 (Wistar), 21865 (SD) and 18120 (rabbits) ng.h/mL, in Wistar, SD and rabbits, respectively. The clearance was slow and supported long half-life (8-10 days). 5. Either one of the two models can serve as a research tool for establishing pharmacokinetics of paliperidone formulation(s).

  4. Induction of HIV-1-specific mucosal immune responses following intramuscular recombinant adenovirus serotype 26 HIV-1 vaccination of humans.

    Science.gov (United States)

    Baden, Lindsey R; Liu, Jinyan; Li, Hualin; Johnson, Jennifer A; Walsh, Stephen R; Kleinjan, Jane A; Engelson, Brian A; Peter, Lauren; Abbink, Peter; Milner, Danny A; Golden, Kevin L; Viani, Kyle L; Stachler, Matthew D; Chen, Benjamin J; Pau, Maria G; Weijtens, Mo; Carey, Brittany R; Miller, Caroline A; Swann, Edith M; Wolff, Mark; Loblein, Hayley; Seaman, Michael S; Dolin, Raphael; Barouch, Dan H

    2015-02-15

    Defining mucosal immune responses and inflammation to candidate human immunodeficiency virus type 1 (HIV-1) vaccines represents a current research priority for the HIV-1 vaccine field. In particular, it is unclear whether intramuscular immunization can elicit immune responses at mucosal surfaces in humans. In this double-blind, randomized, placebo-controlled clinical trial, we evaluated systemic and mucosal immune responses to a candidate adenovirus serotype 26 (Ad26) vectored HIV-1 envelop (Env) vaccine in baseline Ad26-seronegative and Ad26-seropositive healthy volunteers. Systematic mucosal sampling with rectal Weck-Cel sponges and rectal biopsies were performed. Intramuscular immunization elicited both systemic and mucosal Env-specific humoral and cellular immune responses in the majority of subjects. Individuals with preexisting Ad26-specific neutralizing antibodies had vaccine-elicited immune responses comparable to those of subjects who were Ad26 seronegative. We also observed no increase in activated total or vector-specific mucosal CD4+ T lymphocytes following vaccination by either histopathology or flow cytometry. These data demonstrate that a single intramuscular administration of this Ad26-vectored HIV-1 Env vaccine elicited both systemic and mucosal immune responses in humans. Induction of antigen-specific humoral and cellular mucosal immunity was not accompanied by a detectable increase in mucosal inflammation. NCT01103687. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  5. Verification of a standardized method for inserting intramuscular EMG electrodes into uniquely oriented segments of gluteus minimus and gluteus medius.

    Science.gov (United States)

    Semciw, A I; Green, R A; Pizzari, T; Briggs, C

    2013-03-01

    Guidelines for assessing the function of gluteus minimus and gluteus medius with electromyography (EMG) traditionally offer one electrode placement site per muscle. However, anatomical studies suggest that there are two uniquely oriented segments within gluteus minimus (anterior and posterior), and three within gluteus medius (anterior, middle, and posterior) with potential for independent function. Assessment of these muscles with one electrode may therefore provide only a limited account of their role. Thus, the aim of this cadaveric study was to verify guidelines for placing intramuscular electrodes into two uniquely oriented segments of gluteus minimus, and three segments of gluteus medius. The guidelines were developed with reference to anatomical reports, cadaveric observation and real-time ultrasound imaging in vivo. Five cadaveric gluteal regions were marked for intramuscular electrode insertions based on these guidelines. Intramuscular electrodes were inserted into the marked regions of gluteus minimus (2×) and gluteus medius (3×) with the aid of a 15 cm biopsy needle. Systematic dissection revealed that electrodes were successfully inserted into uniquely oriented segments of gluteus minimus and medius. The orientation of fascicles surrounding each electrode was also consistent with segmental descriptions in past anatomical research. The findings of this research suggest that the guidelines described may be used to assess the functional role of segments within gluteus minimus and medius in health and dysfunction using EMG. Finally, electromyographers intent on investigating the role of posterior gluteus minimus must be cautious of the superior gluteal neurovascular bundle. Copyright © 2012 Wiley Periodicals, Inc.

  6. Influenza vaccination in healthcare workers; comparison of side effects and preferred route of administration of intradermal versus intramuscular administration.

    Science.gov (United States)

    Meijer, W J; Wensing, A M J; Bos, A A; Kuiphuis, J C F; Hagelen, E M M; Wilschut, J C; de Vries, M J T; Riezebos-Brilman, A

    2017-03-13

    To explore the nature and severity of side effects and future preference of intradermal versus intramuscular influenza vaccination in healthcare workers. Prospective cohort study. Two University Medical Centers in The Netherlands. Healthcare workers receiving an influenza vaccination. Healthcare workers that were vaccinated during the influenza vaccination season of 2012-2013 were approached for participation in a questionnaire study. The questionnaire was divided into two parts. The first part had to be answered directly after vaccination and the second part two weeks after vaccination. The motivation for vaccine uptake, whether or not the HCWs had direct contact with patients and the prevalence and severity of local and systemic side effects of influenza vaccination were explored. In addition, it was assessed how participants experienced the vaccination and which type of administration they preferred for future vaccination. Side effects of vaccination were more prevalent in the intradermal group versus the intramuscular group (56% versus 26%, pvaccine. Directly after vaccination, healthcare workers preferred the intradermal vaccination. Two weeks after vaccination both types of vaccine were equally appreciated. This study shows that there are significant differences in the nature and severity of side effects upon intramuscular and intradermal influenza vaccination. This difference did not result in a preference among the vaccinated subjects for one type of vaccine. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. Síndrome de HETT - um relato de caso

    Directory of Open Access Journals (Sweden)

    Izilda das Eiras Tâmega

    2016-10-01

    Full Text Available Introdução: Em 1966, Andreas Rett descreveu pela primeira vez a síndrome de Rett, através de um estudo com 31 meninas que desenvolveram quadro de regressão mental, deterioração neuromotora e hiperamonemia. “Atrofia cerebral associada a hiperamonemia. No Brasil os primeiros casos foram identificados em 1986. Cerca de 95% das meninas que preenchem os critérios diagnósticos para a SR, tem uma alteração genética identificável no gene methyl-CpG-binding protein 2 (MECP2 do cromossomo X. Objetivo: Relatar um caso de uma criança admitida no Conjunto Hospitalar de Sorocaba . Metodologia: As informações contidas nesse trabalho foram obtidas por meio de análise de prontuário e revisão de literatura. Relato de caso: K.L.R, sexo feminino, branca, 6 anos e 7 meses, proveniente de Tatuí (SP com queixa de crise convulsiva com 1 ano e 6 meses de idade, encaminhada para o CHS devido a um episódio de vômito, hipotermia e flacidez muscular , esteve internada na origem por 10 dias. A mãe relatou que: que paciente começou a apresentar movimentos repetitivos de cruzar os dedos e “bater palmas”; não conseguia mais segurar objetos. Passou a rejeitar alimentos sólidos. Deixou de falar “mamãe” e “papai” e passou apenas a balbuciar. Os pais ainda relataram que com cerca de 02 anos de idade, passou em consulta com Médico Geneticista, que avaliou a paciente e solicitou Exame Molecular, pensando se tratar de Síndrome de Rett. Com 03 anos e 5 meses, teve episódio súbito de nistago vertical bilateral e rigidez muscular generalizada, com duração de poucos minutos. Foi ajustada a dose da carbamazepina. Conclusão: A síndrome de Rett é uma das causas mais frequentes de deficiência múltipla severa em crianças do sexo feminino, desta forma, os critérios clínicos constituem a base para o diagnóstico. É fundamental o diagnóstico precoce. Além disso, também é importante o apoio às famílias.

  8. Intramuscular delivery of adenovirus serotype 5 vector expressing humanized protective antigen induces rapid protection against anthrax that may bypass intranasally originated preexisting adenovirus immunity.

    Science.gov (United States)

    Wu, Shipo; Zhang, Zhe; Yu, Rui; Zhang, Jun; Liu, Ying; Song, Xiaohong; Yi, Shaoqiong; Liu, Ju; Chen, Jianqin; Yin, Ying; Xu, Junjie; Hou, Lihua; Chen, Wei

    2014-02-01

    Developing an effective anthrax vaccine that can induce a rapid and sustained immune response is a priority for the prevention of bioterrorism-associated anthrax infection. Here, we developed a recombinant replication-deficient adenovirus serotype 5-based vaccine expressing the humanized protective antigen (Ad5-PAopt). A single intramuscular injection of Ad5-PAopt resulted in rapid and robust humoral and cellular immune responses in Fisher 344 rats. Animals intramuscularly inoculated with a single dose of 10⁸ infectious units of Ad5-PAopt achieved 100% protection from challenge with 10 times the 50% lethal dose (LD₅₀) of anthrax lethal toxin 7 days after vaccination. Although preexisting intranasally induced immunity to Ad5 slightly weakened the humoral and cellular immune responses to Ad5-PAopt via intramuscular inoculation, 100% protection was achieved 15 days after vaccination in Fisher 344 rats. The protective efficacy conferred by intramuscular vaccination in the presence of preexisting intranasally induced immunity was significantly better than that of intranasal delivery of Ad5-PAopt and intramuscular injection with recombinant PA and aluminum adjuvant without preexisting immunity. As natural Ad5 infection often occurs via the mucosal route, the work here largely illuminates that intramuscular inoculation with Ad5-PAopt can overcome the negative effects of immunity induced by prior adenovirus infection and represents an efficient approach for protecting against emerging anthrax.

  9. UM OLHAR QUALITATIVO SOBRE AÇÕES PROMOCIONAIS DO SHOPPING TOTAL DA CIDADE DE PORTO ALEGRE

    Directory of Open Access Journals (Sweden)

    Cláudio Damacena

    2012-08-01

    Full Text Available As atitudes e os comportamentos dos consumidores em relação aos shopping centers continuam sendo tópicos importantes de pesquisa na Área de Marketing, principalmente pelo dinamismo da evolução social, econômica e tecnológica e seu impacto no mundo do consumo. Nesse contexto, percebe-se um certo paradoxo, ou seja, o número de shopping centers continua crescendo, entretanto, o número de consumidores que visitam esses empreendimentos não aumenta no mesmo ritmo. Por isso que cada vez mais ações promocionais são realizadas para atrair o consumidor ao shopping center, porém apenas algumas são eficazes. Com o objetivo de explorar essa questão, foi realizada uma pesquisa qualitativa sobre um dos shoppings de uma região metropolitana brasileira, mas especificamente sobre uma de suas ações promocionais. Os resultados do estudo apontam importantes revelações sobre as percepções de lojistas e consumidores acerca de ações promocionais realizadas por shopping centers. Um desses resultados mostra a importância do tempo e da repetição do evento para que possa ser lembrado e associado ao shopping, gerando imagem positiva à marca. Outro resultado importante é a questão da participação de todos os lojistas do shopping center, inclusive nas atividades de entretenimento, no planejamento e na realização da ação promocional. Palavras-chave: Shopping Center. Imagem. Promoção.

  10. "Um minuto para comprar e uma vida para pagar : padrões de interação em casais nos quais um dos membros é diagnosticado como comprador compulsivo

    OpenAIRE

    Guimarães, Cleide Maria Bartholi

    2012-01-01

    O consumo e as formas de dispor do dinheiro têm papel importante na vida cotidiana e permeiam os jogos dos casais. O comportamento de consumo adquiriu relevância acadêmica nas últimas décadas, assim como o comportamento de comprar em demasia, que se traduz na figura do comprador compulsivo. De uma perspectiva sistêmica, a presente pesquisa teve por objetivo mapear os padrões de interação em casais nos quais um dos membros é diagnosticado como comprador compulsivo, abordados por...

  11. Acidos fenólicos en paja de trigo. ¿Son estos los compuestos fenólicos más importantes en la inhibicion del crecimiento de las plantas? Acidos fenólicos en paja de trigo. ¿Son estos los compuestos fenólicos más importantes en la inhibicion del crecimiento de las plantas?

    Directory of Open Access Journals (Sweden)

    Roberto Quintero Lizaola

    2012-02-01

    Full Text Available They were identified the main phenolic acids in wheat straw by high performance liquid chromatography (HPLC, according with those reported by scientific literature as the main allelopathic compounds from wheat straw. The concentrations of these phenolic acids quantified on methanolic extracts by HPLC were very low (among 0.17 and 3.06 % in relationship to the concentration of total soluble phenolics quantified by colorimetry. In the same way, the recuperation percentages of phenolic acids by HPLC in relationship to the total concentration of soluble phenolics quantified by colorimetry in the methanolic extracts varied among 1.28 and 15.18 %. The results shown that it is possible that the identified and quantified phenolic acids by HPLC on wheat straw, could not be the most important phenolic compounds that act as allelopathic agents in some agricultural systems according to their concentrations. Se identificaron los principales ácidos fenólicos presentes en paja de trigo por cromatografía líquida de alta resolución (CLAR, coincidiendo en general con los ácidos fenólicos reportados en la literatura científica como los principales compuestos alelopáticos presentes en la paja de trigo. Las concentraciones de estos ácidos fenólicos, cuantificadas en los extractos metanólicos por CLAR, fueron muy bajas (entre 0.17 % y 3.06 % en relación con la cuantificación de fenólicos solubles totales realizada por colorimetría. Asimismo, los porcentajes de recuperación de los ácidos fenólicos por CLAR, con respecto a las concentraciones de fenólicos solubles totales, determinadas por colorimetría en los extractos metanólicos variaron entre 1.28 % y 15.18 %. Los resultados indican que es posible que los ácidos fenólicos identificados y cuantificados por CLAR en la paja de trigo, pueden no ser los compuestos fenólicos más importantes como agentes alelopáticos en algunos sistemas agrícolas, de acuerdo con las concentraciones cuantificadas.

  12. Existe um Sudoku com 16 pistas?

    OpenAIRE

    Martins, Paula Mendes; Picado, Jorge

    2015-01-01

    Nesta pequena nota damos notícia da resolução recente do problemado número mínimo de pistas de um Sudoku, um problema importanteno estudo matemático do Sudoku, que se manteve em aberto por muitos anos.

  13. Reações dos consumidores a falhas de serviços: um estudo no Brasil e EUA

    OpenAIRE

    Matos, Celso Augusto de; Garrido, Ivan Lapuente; D’Ávila, Lívia Castro; Calixto, Cyntia Vilasboas

    2012-01-01

    Apesar das pesquisas sobre falhas e recuperação de serviços, há poucos estudos investigando o efeito de diferenças culturais. Com base na revisão da literatura, foi proposto um modelo teórico, testado em dados de uma survey realizada junto a 260 consumidores do Brasil e EUA. Os resultados mostraram que a dimensão interpessoal da justiça percebida foi a mais importante para explicar a satisfação do consumidor, que por sua vez influenciou mais fortemente a intenção de reclamar junto a amigos...

  14. Ecologia alimentar e conectividade genética de Chaetodon Striatus em um gradiente geográfico

    OpenAIRE

    Liedke, Ana Maria Rubini

    2013-01-01

    Resumo: Conhecer a ecologia alimentar de uma espécie é um aspecto importante para compreender sua biologia. A relação entre disponibilidade, qualidade do alimento e estado fisiológico reflete na distribuição e abundância de uma dada espécie, e terá influência direta no comportamento alimentar e tipo de presas. A relação entre plasticidade alimentar e fluxo gênico pode levar as populações das extremidades da distribuição a se diferenciarem e possivelmente se adaptarem aos recursos disponíveis....

  15. Religião como variável para se pensar a juventude: um "modo jovem'' de ser religioso

    OpenAIRE

    Assis, Marcos Arcanjo de

    2016-01-01

    A partir da análise dos dados quantitativos sobre religião referentes à Belo Horizonte e cida- des vizinhas, pensa-se a religião como uma variável relevante para a compreensão da juventude. O texto quer mostrar que a religião é também uma variável privilegiada quando se pensa em juventude, e pode trazer importantes inferências para sua compreensão e de um modo jovem de ser religioso. 

  16. Um credo pedagógico na democracia escolar: algum traçado do pensamento de John Dewey = A democratic creed in school’s democracy: John Dewey’s educational thoughts

    Directory of Open Access Journals (Sweden)

    Boto, Carlota

    2006-01-01

    Full Text Available Este artigo pretende trabalhar com o pensamento pedagógico de John Dewey. Filósofo americano, Dewey viveu entre 1859 e 1952 e foi um importante líder do movimento que ficou conhecido nos Estados Unidos da América como educação progressiva. Sua obra constitui importante fonte para compreender os temas da democracia, do interesse, do ensino ativo e da liberdade em contextos educacionais. Por tal razão, suas idéias podem ser consideradas como pioneiras do que aqui compreendemos como segunda geração de direitos educacionais

  17. Mulher, Pampa e natureza: um olhar através de contos puebleros

    Directory of Open Access Journals (Sweden)

    Juliana Corrêa Pereira Schlee

    2016-12-01

    Full Text Available O presente trabalho é um estudo em andamento que se detém nos contos puebleros para deslocar o olhar sobre a mulher, o Pampa e a natureza. Assim, busco a Educação Ambiental, como campo de saber importante e potente para a análise de mundo que temos em seu processo de construção cultural moderno. Entendendo a literatura como pedagogia cultural para problematizar como nos constituímos mulher no Pampa e como nos relacionamos com o discurso de natureza. O Pampa para pensar além de um território geográfico, mas como um lugar que é constituído pelos diversos atravessamentos: biológicos, geográficos, culturais, econômicos, políticos. Modos de ver o mundo, viver e narrar a natureza. Fabricações  histórica e socialmente constituídos em diferentes culturas e em diferentes épocas. É preciso pensar sobre as universalidades de ser mulher, assim como suas relações com a natureza e o pampa.

  18. Um novo Fundef? As idéias de Anísio Teixeira

    Directory of Open Access Journals (Sweden)

    Amaral Nelson Cardoso

    2001-01-01

    Full Text Available O professor Anísio Teixeira, na década de 1960, preocupado com o financiamento da educação, apresentou uma proposta de como definir e implantar um fundo que garantisse recursos permanentes para o ensino primário. Em seus aspectos metodológicos, o Fundo de Manutenção e Desenvolvimento do Ensino Fundamental e de Valorização do Magistério (Fundef, criado pelo Governo, assemelha-se à proposta apresentada por Anísio Teixeira. Existem, entretanto, diferenças importantes e fundamentais, pelo fato do professor Anísio definir o volume total de recursos a partir do estabelecimento do salário dos docentes. Nesse estudo apresentam-se as semelhanças e diferenças entre os dois fundos e realiza-se uma simulação do que se poderia chamar "Um novo Fundef", baseado nas idéias de Anísio Teixeira. Como resultado, obtém-se valores perfeitamente viáveis para serem financiados por uma economia com a dimensão da economia brasileira, assim como ocorreu no estudo apresentado por Anísio Teixeira no livro Educação é um direito.

  19. Desenvolvimento de um ambiente de aprendizagem para o ensino de controle de processos

    Directory of Open Access Journals (Sweden)

    André Pereira da Costa

    2014-12-01

    Full Text Available Esta pesquisa teve como objetivo construir um ambiente de aprendizagem para o ensino de Controle deProcessos, tornando-se um importante recurso didático que favorece o aprendizado dos graduandos do CursoSuperior de Tecnologia em Automação Industrial, no IFPB Campus Cajazeiras. Então, em nosso percursometodológico, utilizamos o software MATLAB, bem como sua linguagem de programação característica, paratornar viável a construção do ambiente. Tal software é bastante utilizado na área de Controle de Processos emdiversas pesquisas, contribuindo tanto para o desenvolvimento prático, pois possibilita que novos métodos decontrole sejam avaliados e empregados nas mais distintas situações, como também no campo educacional.Além disso, utilizamos os pêndulos simples e invertido como modelos mecânicos do simulador. Dentre osresultados obtidos, podemos mencionar a simplicidade de utilização e manipulação do ambiente, pois suainterface gráfica facilita a execução das simulações, de modo dinâmico, na qual o estudante de graduaçãopoderá configurar o sistema e o controlador, além de visualizar o resultado da simulação em um gráfico.

  20. Performance Esportiva ou Performance Administrativa: O Dilema dos Gestores de um Clube de Futebol Brasileiro

    Directory of Open Access Journals (Sweden)

    Renan Bonamigo Tonial

    2017-02-01

    Full Text Available O mercado esportivo mundial assume um papel importante na economia de alguns países. No Brasil, a expressiva movimentação financeira posiciona o futebol como principal esporte desse mercado. Neste contexto está inserido o Grêmio Foot-Ball Porto Alegrense, um clube de futebol profissional com sede na cidade de Porto Alegre, no estado do Rio Grande do Sul. Os gestores responsáveis pelo clube encontram-se em um dilema relacionado as escolhas estratégicas, provocado pela baixa performance esportiva e administrativa do clube. Este caso de ensino, decorrente da consolidação de dados secundários, visando proporcionar a reflexão e promover a discussão sobre temas ligados ao planejamento estratégico, escolha da estratégia competitiva, processo decisório e identificação de perfil dos agentes de tomada de decisão. Desse modo, sugere-se a aplicação do caso nos cursos de graduação e pós-graduação, nas disciplinas de administração estratégica, administração mercadológica e administração esportiva.

  1. Mobilidade urbana: um desafio paulistano

    Directory of Open Access Journals (Sweden)

    Jorge Wilheim

    2013-01-01

    Full Text Available Na "leitura" de uma cidade distingo infraestruturas físicas e sistemas de vida, a fim de avaliar se as primeiras dão suporte adequado às segundas. Para a abordagem e compreensão da cidade dou mais importância a aspectos antropológicos do que aos estatísticos. Para avaliar mobilidade urbana há que considerar três fluxos: os imateriais (informações, cargas (bens e pessoas. Na de pessoas há expectativa de proximidade de embarque, pontualidade e conforto. Transporte público é sistema, do qual participam os diversos modais, inclusive o do pedestre. No futuro haverá mais locação do que propriedade privada do automóvel; e indústria de reciclagem dos elementos de carros usados. Deve o direito à mobilidade ser gratuito para o usuário ou ser por ele pago com subsídio? Políticas públicas deverão ter no urbanismo um processo de melhor gestão urbana, diminuir necessidade de deslocamentos, alterar o uso do carro, monitorar serviços com participação pública, sistematizar modais, garantir pontualidade e conforto do transporte.

  2. Relationship between medical compression and intramuscular pressure as an explanation of a compression paradox.

    Science.gov (United States)

    Uhl, J-F; Benigni, J-P; Cornu-Thenard, A; Fournier, J; Blin, E

    2015-06-01

    Using standing magnetic resonance imaging (MRI), we recently showed that medical compression, providing an interface pressure (IP) of 22 mmHg, significantly compressed the deep veins of the leg but not, paradoxically, superficial varicose veins. To provide an explanation for this compression paradox by studying the correlation between the IP exerted by medical compression and intramuscular pressure (IMP). In 10 legs of five healthy subjects, we studied the effects of different IPs on the IMP of the medial gastrocnemius muscle. The IP produced by a cuff manometer was verified by a Picopress® device. The IMP was measured with a 21G needle connected to a manometer. Pressure data were recorded in the prone and standing positions with cuff manometer pressures from 0 to 50 mmHg. In the prone position, an IP of less than 20 did not significantly change the IMP. On the contrary, a perfect linear correlation with the IMP (r = 0.99) was observed with an IP from 20 to 50 mmHg. We found the same correlation in the standing position. We found that an IP of 22 mmHg produced a significant IMP increase from 32 to 54 mmHg, in the standing position. At the same time, the subcutaneous pressure is only provided by the compression device, on healthy subjects. In other words, the subcutaneous pressure plus the IP is only a little higher than 22 mmHg-a pressure which is too low to reduce the caliber of the superficial veins. This is in accordance with our standing MRI 3D anatomical study which showed that, paradoxically, when applying low pressures (IP), the deep veins are compressed while the superficial veins are not. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  3. Florfenicol pharmacokinetics in healthy adult alpacas after subcutaneous and intramuscular injection.

    Science.gov (United States)

    Holmes, K; Bedenice, D; Papich, M G

    2012-08-01

    A single dose of florfenicol (Nuflor(®)) was administered to eight healthy adult alpacas at 20 mg/kg intramuscular (i.m.) and 40 mg/kg subcutaneous (s.c.) using a randomized, cross-over design, and 28-day washout period. Subsequently, 40 mg/kg florfenicol was injected s.c. every other day for 10 doses to evaluate long-term effects. Maximum plasma florfenicol concentrations (C(max), measured via high-performance liquid chromatography) were achieved rapidly, leading to a higher C(max) of 4.31±3.03 μg/mL following administration of 20 mg/kg i.m. than 40 mg/kg s.c. (C(max): 1.95±0.94 μg/mL). Multiple s.c. dosing at 48 h intervals achieved a C(max) of 4.48±1.28 μg/mL at steady state. The area under the curve and terminal elimination half-lives were 51.83±11.72 μg/mL·h and 17.59±11.69 h after single 2 mg/kg i.m. dose, as well as 99.78±23.58 μg/mL·h and 99.67±59.89 h following 40 mg/kg injection of florfenicol s.c., respectively. Florfenicol decreased the following hematological parameters after repeated administration between weeks 0 and 3: total protein (6.38 vs. 5.61 g/dL, Pflorfenicol should thus be used in alpacas and limited to treatment of highly susceptible pathogens. © 2011 Blackwell Publishing Ltd.

  4. Pharmacokinetics of a new diclofenac sodium formulation developed for subcutaneous and intramuscular administration.

    Science.gov (United States)

    Zeitlinger, Markus; Rusca, Antonio; Oraha, Alhan Z; Gugliotta, Barbara; Müller, Markus; Ducharme, Murray P

    2012-06-01

    To assess the relative bioavailability of diclofenac sodium hydroxypropyl β-cyclodextrin (HPβCD) administered via the subcutaneous (s.c.) and intramuscular (i.m.) route versus Voltaren® i.m. and to evaluate the dose linearity and pharmacokinetics of the s.c. formulation at three dose levels. Safety and local tolerability were also assessed. One single-dose, randomized, three-way, crossover relative bioavailability study and one linearity single escalating dose, randomized, three-way cross-over pharmacokinetic study were conducted at two different clinical sites. A total of 42 healthy male and female subjects participated in both studies. Subjects received 75 mg/ml diclofenac sodium HPβCD (i.m. and s.c.) and Voltaren® 75 mg/3 ml (i.m.) in Study 1 and 25, 50, or 75 mg/ml diclofenac sodium HPβCD (s.c.) in Study 2. Study 1 demonstrated bioequivalence of the s.c. test formulation with Voltaren® i.m. with respect to Cmax and AUC. Bioequivalence of the test i.m. with Voltaren® i.m. was also demonstrated (except the upper limit of the 90% confidence interval (CI) for Cmax which marginally exceeded the 80 - 125% range (125.78%)). Study 2 demonstrated that after s.c. administration of the test formulation, both Cmax and AUC are linearly related to the tested diclofenac doses. All tested doses were safe and locally well-tolerated with no serious adverse events reported. Bioequivalence of diclofenac HPβCD 75 mg/ml after s.c. and i.m. administration with Voltaren® i.m. was demonstrated, except for the marginal deviation in Cmax when comparing the i.m. test and Voltaren®. Linearity was also demonstrated for the three doses intended for marketing.

  5. Artesunate Suppositories versus Intramuscular Artemether for Treatment of Severe Malaria in Children in Papua New Guinea

    Science.gov (United States)

    Karunajeewa, Harin A.; Reeder, John; Lorry, Kerry; Dabod, Elizah; Hamzah, Juliana; Page-Sharp, Madhu; Chiswell, Gregory M.; Ilett, Kenneth F.; Davis, Timothy M. E.

    2006-01-01

    Drug treatment of severe malaria must be rapidly effective. Suppositories may be valuable for childhood malaria when circumstances prevent oral or parenteral therapy. We compared artesunate suppositories (n = 41; 8 to 16 mg/kg of body weight at 0 and 12 h and then daily) with intramuscular (i.m.) artemether (n = 38; 3.2 mg/kg at 0 h and then 1.6 mg/kg daily) in an open-label, randomized trial with children with severe Plasmodium falciparum malaria in Papua New Guinea (PNG). Parasite density and temperature were measured every 6 h for ≥72 h. Primary endpoints included times to 50% and 90% parasite clearance (PCT50 and PCT90) and the time to per os status. In a subset of 29 patients, plasma levels of artemether, artesunate, and their common active metabolite dihydroartemisinin were measured during the first 12 h. One suppository-treated patient with multiple complications died within 2 h of admission, but the remaining 78 recovered uneventfully. Compared to the artemether-treated children, those receiving artesunate suppositories had a significantly earlier mean PCT50 (9.1 versus 13.8 h; P = 0.008) and PCT90 (15.6 versus 20.4 h; P = 0.011). Mean time to per os status was similar for each group. Plasma concentrations of primary drug plus active metabolite were significantly higher in the artesunate suppository group at 2 h postdose. The earlier initial fall in parasitemia with artesunate is clinically advantageous and mirrors higher initial plasma concentrations of active drug/metabolite. In severely ill children with malaria in PNG, artesunate suppositories were at least as effective as i.m. artemether and may, therefore, be useful in settings where parenteral therapy cannot be given. PMID:16495259

  6. Artesunate suppositories versus intramuscular artemether for treatment of severe malaria in children in Papua New Guinea.

    Science.gov (United States)

    Karunajeewa, Harin A; Reeder, John; Lorry, Kerry; Dabod, Elizah; Hamzah, Juliana; Page-Sharp, Madhu; Chiswell, Gregory M; Ilett, Kenneth F; Davis, Timothy M E

    2006-03-01

    Drug treatment of severe malaria must be rapidly effective. Suppositories may be valuable for childhood malaria when circumstances prevent oral or parenteral therapy. We compared artesunate suppositories (n = 41; 8 to 16 mg/kg of body weight at 0 and 12 h and then daily) with intramuscular (i.m.) artemether (n = 38; 3.2 mg/kg at 0 h and then 1.6 mg/kg daily) in an open-label, randomized trial with children with severe Plasmodium falciparum malaria in Papua New Guinea (PNG). Parasite density and temperature were measured every 6 h for > or = 72 h. Primary endpoints included times to 50% and 90% parasite clearance (PCT50 and PCT90) and the time to per os status. In a subset of 29 patients, plasma levels of artemether, artesunate, and their common active metabolite dihydroartemisinin were measured during the first 12 h. One suppository-treated patient with multiple complications died within 2 h of admission, but the remaining 78 recovered uneventfully. Compared to the artemether-treated children, those receiving artesunate suppositories had a significantly earlier mean PCT50 (9.1 versus 13.8 h; P = 0.008) and PCT90 (15.6 versus 20.4 h; P = 0.011). Mean time to per os status was similar for each group. Plasma concentrations of primary drug plus active metabolite were significantly higher in the artesunate suppository group at 2 h postdose. The earlier initial fall in parasitemia with artesunate is clinically advantageous and mirrors higher initial plasma concentrations of active drug/metabolite. In severely ill children with malaria in PNG, artesunate suppositories were at least as effective as i.m. artemether and may, therefore, be useful in settings where parenteral therapy cannot be given.

  7. Intramuscular ziprasidone versus haloperidol for managing agitation in Chinese patients with schizophrenia.

    Science.gov (United States)

    Zhang, Hongyan; Wang, Gang; Zhao, Jingping; Xie, Shiping; Xu, Xiufeng; Shi, Jianguo; Deng, Hehuang; Li, Keqing; Gao, Chengge; Wang, Xiaoping; Vanderburg, Douglas; Pan, Sharon; Tang, Haiyun; Shu, Liang; Karayal, Onur N

    2013-04-01

    Intramuscular (IM) antipsychotics are preferred for efficient control of agitation symptoms. Previous studies have demonstrated that IM ziprasidone is efficacious and safe for treatment of agitation in schizophrenia. However, clinicians now recognize that racial differences may contribute to altered therapeutic response and tolerability. This study compared the efficacy and tolerability of IM ziprasidone versus IM haloperidol for the management of agitation in Chinese subjects with schizophrenia. Subjects with acute schizophrenia were randomized to either ziprasidone (n = 189, 10 to 20 mg as required up to a maximum of 40 mg/d) or haloperidol (n = 187, 5 mg every 4 to 8 hours to a maximum of 20 mg/d) for 3 days. Psychiatric assessments and adverse events were assessed at baseline, 2, 4, 24, 48, and 72 hours. In the ziprasidone group, 2.1% of subjects discontinued versus 3.7% in the haloperidol group. The least squares mean change (SE) from baseline to 72 hours in Brief Psychiatry Rating Scale total score was -17.32 (0.7) for ziprasidone (n = 167) and -18.44 (0.7) for haloperidol (n = 152), with a 95% confidence interval treatment difference of -0.7 to 2.9. Fewer subjects experienced adverse events after ziprasidone (n = 54, 28.6%) than haloperidol (n = 116, 62.0%), with a notably higher incidence of extrapyramidal symptoms in the haloperidol group (n = 69, 36.9%) compared to the ziprasidone group (n = 4, 2.1%). For controlling agitation in schizophrenia in this Chinese study, ziprasidone had a favorable tolerability profile and comparable efficacy and safety compared to haloperidol.

  8. Fatty Acids Profile of Intramuscular Fat in Light Lambs Traditionally and Artificially Reared

    Directory of Open Access Journals (Sweden)

    Milan MARGETÍN

    2014-03-01

    Full Text Available The quality of 40 carcasses of light lambs of the synthetic population of Slovak Dairy sheep from (a artificial rearing (AR and (b traditional rearing (TR was assessed on the basis of fatty acids profile of intramuscular fat (IMF. Lambs from AR in comparison with TR were of lower quality as assessed on the basis of fatty acids (FAs profile. The content of conjugated linolic acid (CLA in the fat of TR lambs was severalfold higher (0.749 vs. 0.193 g.100g-1 FAME, P<0.001 than in AR lambs. Similarly, the content of trans-vaccenic (TVA, á-linolenic (ALA, rumenic (RA, eicosapentaenoic (EPA and docosahexaenoic acid (DHA was in TR lambs significantly higher (P<0.001 than in AR lambs (0.955 vs. 0.111; 0.715 vs. 0.251; 0.672 vs. 0.148; 0.352 vs. 0.061; 0.252 vs. 0.079 g.100g-1 FAME. In contrary, the content of linoleic acid (LA, the ratio of LA/ALA and n-6/n-3 in AR lambs was higher than in TR lambs (9.07 vs. 4.81 g.100 g-1 FAME; 39.11 vs. 6.80; 14.56 vs. 3.25, P<0.001. In TR lambs the content of n-3 PUFA and BCFA was significantly higher (P<0.001 than in AR lambs (2.08 vs. 0.84 and 1.95 vs. 0.45. The value of thrombogenic index was higher in AR lambs in comparison with TR lambs (1.44 vs. 1.31; P<0.05. Significant differences between FAs of IMF of ram lambs and ewe lambs were observed only in the case of arachidonic acid (P<0.05.

  9. Pharmacokinetic and pharmacodynamic modelling of intravenous, intramuscular and subcutaneous buprenorphine in conscious cats.

    Science.gov (United States)

    Steagall, Paulo V M; Pelligand, Ludovic; Giordano, Tatiana; Auberger, Christophe; Sear, John W; Luna, Stelio P L; Taylor, Polly M

    2013-01-01

    To describe simultaneous pharmacokinetics (PK) and thermal antinociception after intravenous (i.v.), intramuscular (i.m.) and subcutaneous (SC) buprenorphine in cats. Randomized, prospective, blinded, three period crossover experiment. Six healthy adult cats weighing 4.1±0.5 kg. Buprenorphine (0.02 mg kg(-1)) was administered i.v., i.m. or s.c.. Thermal threshold (TT) testing and blood collection were conducted simultaneously at baseline and at predetermined time points up to 24 hours after administration. Buprenorphine plasma concentrations were determined by liquid chromatography tandem mass spectrometry. TT was analyzed using anova (pbuprenorphine concentration-time data decreased curvilinearly. S.c. PK could not be modeled due to erratic absorption and disposition. I.v. buprenorphine disposition was similar to published data. The PK-PD model showed an onset delay mainly attributable to slow biophase equilibration (t(1/2) k(e0)=47.4 minutes) and receptor binding (k(on)=0.011 mL ng(-1) minute(-1)). Persistence of thermal antinociception was due to slow receptor dissociation (t(1/2) k(off)=18.2 minutes). I.v. and i.m. data followed classical disposition and elimination in most cats. Plasma concentrations after i.v. administration were associated with antinociceptive effect in a PK-PD model including negative hysteresis. At the doses administered, the i.v. route should be preferred over the i.m. and s.c. routes when buprenorphine is administered to cats. © 2012 The Authors. Veterinary Anaesthesia and Analgesia. © 2012 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesiologists.

  10. Pregnancy-induced adaptations in intramuscular extracellular matrix of rat pelvic floor muscles.

    Science.gov (United States)

    Alperin, Marianna; Kaddis, Timothy; Pichika, Rajeswari; Esparza, Mary C; Lieber, Richard L

    2016-08-01

    Birth trauma to pelvic floor muscles is a major risk factor for pelvic floor disorders. Intramuscular extracellular matrix determines muscle stiffness, supports contractile component, and shields myofibers from mechanical strain. Our goal was to determine whether pregnancy alters extracellular matrix mechanical and biochemical properties in a rat model, which may provide insights into the pathogenesis of pelvic floor muscle birth injury. To examine whether pregnancy effects were unique to pelvic floor muscles, we also studied a hind limb muscle. Passive mechanical properties of coccygeus, iliocaudalis, pubocaudalis, and tibialis anterior were compared among 3-month old Sprague-Dawley virgin, late-pregnant, and postpartum rats. Muscle tangent stiffness was calculated as the slope of the stress-sarcomere length curve between 2.5 and 4.0 μm, obtained from a stress-relaxation protocol at a bundle level. Elastin and collagen isoform concentrations were quantified by the use of enzyme-linked immunosorbent assay. Enzymatic and glycosylated collagen crosslinks were determined by high-performance liquid chromatography. Data were compared by the use of repeated-measures, 2-way analysis of variance with Tukey post-hoc testing. Correlations between mechanical and biochemical parameters were assessed by linear regressions. Significance was set to P pelvic floor muscle stiffness did not differ from virgins (P > .3). A substantial increase in collagen V in coccygeus and pubocaudalis was observed in late-pregnant, compared with virgin, animals, (P pelvic floor muscles (P pelvic floor muscles, the tibialis anterior was unaltered by pregnancy. In contrast to other pelvic tissues, pelvic floor muscle stiffness increased in pregnancy, returning to prepregnancy state postpartum. This adaptation may shield myofibers from excessive mechanical strain during parturition. Biochemical alterations in pelvic floor muscle extracellular matrix due to pregnancy include increase in collagen V

  11. Development and comparison of intramuscularly long-acting paliperidone palmitate nanosuspensions with different particle size.

    Science.gov (United States)

    Leng, Donglei; Chen, Hongming; Li, Guangjing; Guo, Mengran; Zhu, Zhaolu; Xu, Lu; Wang, Yongjun

    2014-09-10

    The main purpose of this study was to develop and compare the pharmacokinetic behavior of two paliperidone palmitate (PP) nanosuspensions with different particle size after intramuscular (i.m.) administration. PP nanosuspensions were prepared by wet media milling method and the mean particle size of nanosuspension was controlled as 1,041 ± 6 nm (A) and 505 ± 9 nm (B), respectively. The morphology of nanosuspensions was observed by scanning electron microscope (SEM). Differential scanning calorimeter (DSC) and powder X-ray diffraction (PXRD) confirmed the crystallinity of PP in nanosuspensions. The physical and chemical stabilities of nanosuspensions A and B were investigated by particle analyzer and HPLC after storage for 2 months at 25°C, 4°C and mechanical shaking condition. No obvious change in particle size and chemical degradation of drug were observed. Following single-dose i.m. administration to beagle dogs, the release of paliperidone lasted for nearly 1 month. The Tmax of nanosuspensions A and B was 6 (d) and 10 (d). The AUC0-t and Cmax of nanosuspensions A was 2.0-fold and 1.8-fold higher than nanosuspensions B (p<0.05). The results demonstrated that PP nanosuspensions formulation had long-acting effect. Nanosuspension A with a larger particle size performed better than nanosuspension B. As a result, it is important to design appropriate particle size of nanosuspensions for i.m. administration in order to produce larger therapeutic effect. Copyright © 2014 Elsevier B.V. All rights reserved.

  12. The effect of intramuscular administration of medroxy progesterone acetate (MPA on electrocardiographic alterations of female dogs

    Directory of Open Access Journals (Sweden)

    M Neshat Gharamaleky

    2010-11-01

    Full Text Available Progestins are useful for hormonal prevention of pregnancy in humans and animals. Progestrone and medroxy progestrone acetate are used for treatment of premenopausal syndrome and decreasing complications of estrogen therapy after menopause. Prescription of progesterone in dogs is usually done to control or delay estrus. If this drug is used at anestrous it will inhibit the gonadotropin excretion beyond the basic level and it will prevent cycle from happening again in proestrus or at the beginning of estrus progesterone will prevent ovulation. Use of progesterone is not totally safe in bitches. It can cause several problems such as cystic endometrial hyperplasia and pyrometera. In this study the effects of medroxy progestrone acetat (MPA on electrocardiographic changes are evaluated. After nutritional and environmental uniformity and other evaluations, the animals were divided into two groups with six bitches in each group. MPA was used at 10 mg/kg for the first group and 20 mg/kg for the second group. An ECG was recorded from the first group in time zero. MPA was injected intramuscularly and immediately after ECG recording and the time of injection was noted. Another ECG was recorded 0.5 and 2 hours after injection. The same process was repeated for the second group. It was observed that MPA at 20 mg/kg increased the heart rate and consequently PR interval and RR interval were decreased significantly in normal range. Also administration of drug at 10 mg/kg decreased the heart rate and increased PR interval, QT interval and RR interval significantly in normal range. It is probable that these observations are the result of MPAs dose dependent vasodilatory nature that induces the heart to exhibit compensative reactions such as increasing heart rate.

  13. Highly delayed systemic translocation of aluminum-based adjuvant in CD1 mice following intramuscular injections.

    Science.gov (United States)

    Crépeaux, Guillemette; Eidi, Housam; David, Marie-Odile; Tzavara, Eleni; Giros, Bruno; Exley, Christopher; Curmi, Patrick A; Shaw, Christopher A; Gherardi, Romain K; Cadusseau, Josette

    2015-11-01

    Concerns regarding vaccine safety have emerged following reports of potential adverse events in both humans and animals. In the present study, alum, alum-containing vaccine and alum adjuvant tagged with fluorescent nanodiamonds were used to evaluate i) the persistence time at the injection site, ii) the translocation of alum from the injection site to lymphoid organs, and iii) the behavior of adult CD1 mice following intramuscular injection of alum (400 μg Al/kg). Results showed for the first time a strikingly delayed systemic translocation of adjuvant particles. Alum-induced granuloma remained for a very long time in the injected muscle despite progressive shrinkage from day 45 to day 270. Concomitantly, a markedly delayed translocation of alum to the draining lymph nodes, major at day 270 endpoint, was observed. Translocation to the spleen was similarly delayed (highest number of particles at day 270). In contrast to C57BL/6J mice, no brain translocation of alum was observed by day 270 in CD1 mice. Consistently neither increase of Al cerebral content, nor behavioral changes were observed. On the basis of previous reports showing alum neurotoxic effects in CD1 mice, an additional experiment was done, and showed early brain translocation at day 45 of alum injected subcutaneously at 200 μg Al/kg. This study confirms the striking biopersistence of alum. It points out an unexpectedly delayed diffusion of the adjuvant in lymph nodes and spleen of CD1 mice, and suggests the importance of mouse strain, route of administration, and doses, for future studies focusing on the potential toxic effects of aluminum-based adjuvants. Copyright © 2015 Elsevier Inc. All rights reserved.

  14. Pregnancy-induced adaptations in intramuscular extracellular matrix of rat pelvic floor muscles

    Science.gov (United States)

    Alperin, Marianna; Kaddis, Timothy; Pichika, Rajeswari; Esparza, Mary C.; Lieber, Richard L.

    2017-01-01

    BACKGROUND Birth trauma to pelvic floor muscles is a major risk factor for pelvic floor disorders. Intramuscular extracellular matrix determines muscle stiffness, supports contractile component, and shields myofibers from mechanical strain. OBJECTIVE Our goal was to determine whether pregnancy alters extracellular matrix mechanical and biochemical properties in a rat model, which may provide insights into the pathogenesis of pelvic floor muscle birth injury. To examine whether pregnancy effects were unique to pelvic floor muscles, we also studied a hind limb muscle. STUDY DESIGN Passive mechanical properties of coccygeus, iliocaudalis, pubocaudalis, and tibialis anterior were compared among 3-month old Sprague–Dawley virgin, late-pregnant, and postpartum rats. Muscle tangent stiffness was calculated as the slope of the stress–sarcomere length curve between 2.5 and 4.0 μm, obtained from a stress-relaxation protocol at a bundle level. Elastin and collagen isoform concentrations were quantified by the use of enzyme-linked immunosorbent assay. Enzymatic and glycosylated collagen crosslinks were determined by high-performance liquid chromatography. Data were compared by the use of repeated-measures, 2-way analysis of variance with Tukey post-hoc testing. Correlations between mechanical and biochemical parameters were assessed by linear regressions. Significance was set to P pelvic floor muscle stiffness did not differ from virgins (P > .3). A substantial increase in collagen V in coccygeus and pubocaudalis was observed in late-pregnant, compared with virgin, animals, (P pelvic floor muscles (P pelvic floor muscles, the tibialis anterior was unaltered by pregnancy. CONCLUSIONS In contrast to other pelvic tissues, pelvic floor muscle stiffness increased in pregnancy, returning to prepregnancy state post-partum. This adaptation may shield myofibers from excessive mechanical strain during parturition. Biochemical alterations in pelvic floor muscle extracellular matrix

  15. Sedative and antinociceptive effects of dexmedetomidine and buprenorphine after oral transmucosal or intramuscular administration in cats.

    Science.gov (United States)

    Porters, Nathalie; Bosmans, Tim; Debille, Mariëlla; de Rooster, Hilde; Duchateau, Luc; Polis, Ingeborgh

    2014-01-01

    To compare sedation and antinociception after oral transmucosal (OTM) and intramuscular (IM) administration of a dexmedetomidine-buprenorphine combination in healthy adult cats. Randomized, 'blinded' crossover study, with 1 month washout between treatments. Six healthy neutered female cats, weighing 5.3-7.5 kg. A combination of dexmedetomidine (40 μg kg(-1) ) and buprenorphine (20 μg kg(-1) ) was administered by either the OTM (buccal cavity) or IM (quadriceps muscle) route. Sedation was measured using a numerical rating scale, at baseline and at various time points until 6 hours after treatment. At the same time points, analgesia was scored using a dynamic and interactive visual analogue scale, based on the response to an ear pinch, and by the cat's response to a mechanical stimulus exerted by a pressure rate onset device. Physiological and adverse effects were recorded, and oral pH measured. Signed rank tests were performed, with significance set at p < 0.05. Data are presented as median and range. There were no differences in sedation or antinociception scores between OTM and IM dosing at any of the time points. Nociceptive thresholds increased after both treatments but without significant difference between groups. Buccal pH remained between 8 and 8.5. Salivation was noted after OTM administration (n = 2) and vomiting after both OTM (n = 4), and IM (n = 3) dosing. In healthy adult cats, OTM administration of dexmedetomidine and buprenorphine resulted in comparable levels of sedation and antinociception to IM dosing. The OTM administration may offer an alternative route to administer this sedative-analgesic combination in cats. © 2013 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia.

  16. Vascular development during distraction osteogenesis proceeds by sequential intramuscular arteriogenesis followed by intraosteal angiogenesis.

    Science.gov (United States)

    Morgan, Elise F; Hussein, Amira I; Al-Awadhi, Bader A; Hogan, Daniel E; Matsubara, Hidenori; Al-Alq, Zainab; Fitch, Jennifer; Andre, Billy; Hosur, Krutika; Gerstenfeld, Louis C

    2012-09-01

    the intramuscular compartment into the regions of osseous regeneration. Copyright © 2012 Elsevier Inc. All rights reserved.

  17. Intramuscular injection of alfaxalone in combination with butorphanol for sedation in cats.

    Science.gov (United States)

    Deutsch, Julia; Jolliffe, Colette; Archer, Emma; Leece, Elizabeth A

    2017-07-01

    To assess quality of sedation following intramuscular (IM) injection of two doses of alfaxalone in combination with butorphanol in cats. Prospective, randomized, 'blinded' clinical study. A total of 38 cats undergoing diagnostic imaging or noninvasive procedures. Cats were allocated randomly to be administered butorphanol 0.2 mg kg -1 combined with alfaxalone 2 mg kg -1 (group AB2) or 5 mg kg -1 (group AB5) IM. If sedation was inadequate, alfaxalone 2 mg kg -1 IM was administered and cats were excluded from further analysis. Temperament [1 (friendly) to 5 (aggressive)], response to injection, sedation score at 2, 6, 8, 15, 20, 30, 40, 50 and 60 minutes, overall sedation quality scored after data collection [1 (excellent) to 4 (inadequate)] and recovery quality were assessed. Heart rate (HR), respiratory rate (f R ) and arterial haemoglobin saturation (SpO 2 ) were recorded every 5 minutes. Groups were compared using t tests and Mann-Whitney U tests. Sedation was analysed using two-way anova, and additional alfaxalone using Fisher's exact test (p cats in AB2 and two in AB5 (p = 0.005). Recovery quality, HR, f R and SpO 2 were similar. Seven cats required oxygen supplementation. Complete recovery times were shorter in AB2 (81.8 ± 24.3 versus 126.6 ± 33.3 minutes; p = 0.009). Twitching was the most common adverse event. In combination with butorphanol, IM alfaxalone at 5 mg kg -1 provided better quality sedation than 2 mg kg -1 . Monitoring of SpO 2 is recommended. Copyright © 2017 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.

  18. Efficacy of Sublingual Misoprostol versus Intramuscular Methylergometrine in Prevention of Primary Postpartum Hemorrhage

    International Nuclear Information System (INIS)

    Anwar, R.; Ambreen, A.; Khuram, A.; Mushtaq, M.

    2013-01-01

    Post partum hemorrhage still remains a major cause of maternal morbidity and mortality in developing countries. Most of oxytocics like methylergometrine require parenteral administration, which requires special storage. Misoprostol is thermo stable, has a long shelf life and is widely recommended for prevention of postpartum hemorrhage. This can be a choice of oxytocic in developing countries like ours, where storage facilities and resources are limited. Objectives: To compare efficacy of sublingual Misoprostol versus intramuscular Methylergometrine in prevention of primary postpartum hemorrhage after delivery. Study Design: Quasi experimental study Place and Duration of Study: Department of Gynae/Obs, Military Hospital and Combined Military Hospital Rawalpindi cantt. December 2007 to July 2008. Material and Methods: One hundred and thirty six pregnant ladies were selected. On arrival each patient was examined thoroughly along with baseline investigations. Therapeutic option was allocated to the patients simply by using a table of random numbers and dividing them in two equal groups. Informed written consent was taken. Each patient was observed for blood loss estimation and hematocrit drop. All the data was analyzed using SPSS version 10.0. Mean +- SD for age, pre-delivery and post-delivery hematocrit, percentage of drop in hematocrit and blood loss during labour was calculated. Results: Mean drop of hematocrit and blood loss were compared among two groups. At the end, it was revealed that there was no significant difference among two groups in blood loss (p=0.49) and hematocrit drop (p=0.14). Conclusion: There is no significant better effect in preventing post partum hemorrhage among the two drugs. (author)

  19. Lack of gender effect on the pharmacokinetics of oxytetracycline in Fenneropenaeus chinensis after intramuscular administration

    Science.gov (United States)

    Sun, Ming; Li, Jian; Chang, Zhiqiang; Guo, Wenting; Zhao, Fazhen; Li, Jitao

    2015-04-01

    Fenneropenaeus chinensis, an economically important shrimp species, currently suffers from epizootic diseases due to high density stocking and bacterial infections. Oxytetracycline (OTC) has been widely used to treat various systemic bacterial infections in shrimp farming. In the present study, the effect of gender on pharmacokinetics of OTC in F. chinensis was investigated. The OTC concentrations in hemolymph of shrimp after single intramuscular administration (75 mg OTC per kg body weight) were analyzed by high performance liquid chromatography and best described with a two-compartment open model which is characterized by a short elimination half-life, low clearance, and a relatively large apparent volume of distribution. The pharmacokinetic equations were C t = 58.54e-0.38 t + 11.67e-0.04 t for females; and C t = 27.94e-0.28 t + 14.87e-0.04 t for males. The distribution and elimination half-lives of OTC were 1.82 and 19.58 h, respectively, in females and 2.50 and 16.11 h, respectively, in males at 22°C. The areas under the drug concentration curve were 480 mg L-1 h-1 in females and 430 mg L-1 h-1 in males. The total body clearance of the drug was 157.11 mL kg-1 h-1 in females and 172.47 mL kg-1 h-1 in males. The apparent volume distribution was 4.44 in females and 4.01 L kg-1 in males. There was no significant difference in pharmacokinetic parameters between female and male shrimps, indicating that there is no need to consider the gender effect in clinical use of OTC in F. chinensis farming.

  20. Metabolism of [14C]Cefmenoxime in normal subjects after intramuscular administration

    International Nuclear Information System (INIS)

    Machinist, J.M.; Bopp, B.A.; Quinn, D.

    1984-01-01

    The metabolism of cefmenoxime (SCE-1365) was studied in four healthy male volunteers after intramuscular administration of a single 500-mg dose of the 14C-labeled drug. Plasma levels of total radioactivity and cefmenoxime peaked at 0.5 and 1.0 h, corresponding to 16.5 micrograms eq/ml and 15.8 micrograms/ml, respectively. Thereafter, parent drug levels declined rapidly, with a terminal elimination half-life of ca. 1.5 h. No significant differences were noted between total radioactivity and parent drug levels up to 2 h after drug administration. After 3 h, low but persistent levels of radioactivity were significantly greater than parent drug levels, indicating metabolism or degradation of cefmenoxime. The terminal elimination half-life of total radioactivity was estimated to be ca. 40 h. The radioactive plasma metabolite(s) remaining at the end of the 5-day study represented only 1% of the administered dose. Urinary excretion was the major route of elimination of cefmenoxime, accounting for ca. 86% of the dose in 12 h. Analysis of cefmenoxime in urine by total radioactivity, high-pressure liquid chromatography, and a microbiological assay showed that 80 to 92% of the excreted dose was parent drug. Radioactivity was also excreted into the feces via the bile and represented ca. 11% of the dose after 5 days. Although extensive degradation of cefmenoxime was found in fecal samples, it was proposed that this may be due to the metabolic activity of the intestinal flora rather than in vivo biotransformation in the liver. This study supports the concept that cefmenoxime undergoes minimal metabolism in humans and is excreted largely as unchanged drug

  1. Pharmacokinetic behavior of meloxicam in loggerhead sea turtles (Caretta caretta) after intramuscular and intravenous administration.

    Science.gov (United States)

    Lai, Olimpia R; Di Bello, Antonio; Soloperto, Simona; Freggi, Daniela; Marzano, Giacomo; Cavaliere, Leonardo; Crescenzo, Giuseppe

    2015-04-01

    Data on reptile analgesia are scarce for nonsteroidal anti-inflammatory drugs (NSAIDs) and opioids and almost completely lacking in sea turtles, even though emergencies requiring correct pain management are very frequent in their rehabilitative medicine; therefore, dosage regimens extrapolated from other species involve the risk of clinical failure and damage to the animals. We describe the pharmacokinetic behavior of meloxicam in the loggerhead sea turtle (Caretta caretta). We chose meloxicam because of its selective anti-cyclooxygenase-2 activity and lesser adverse side effects. No data are available on the capacity of turtles to tolerate NSAIDs, so we chose a dose of 0.1 mg/kg of meloxicam. Plasma concentrations of meloxicam were unexpectedly low both for intravenous (IV; maximum concentration [C(max)] = 0.04±0.02 µg/mL) and intramuscular (IM; C(max) = 0.07±0.09 µg/mL) administration. A double-peak phenomenon occurred after both IV (time for second peak concentration T(max2) = 10.33±10.89 h) and IM (T(max2) = 1.17±0.75 h). The second peak after IM injection was premature, so some difficulty and delay in absorption appears to be an appropriate explanation. Furthermore, the area under the curve, and therefore systemic bioavailability (F = 31.82±28.24%), after both IV (0.30±0.29) and IM (0.10±0.03) injection appeared particularly limited. Terminal elimination slope and mean residence time indicated fast elimination after IM dosing; as a consequence, plasma concentrations dropped below analytic limits in 8 h. Considering that IM is the favored route of administration of drugs in rescue centers, it is unlikely that meloxicam at 0.1 mg/kg is an appropriate choice, particularly in long-term pain management protocols.

  2. Comparison of intranasal and intramuscular ketamine-midazolam combination in cats.

    Science.gov (United States)

    Marjani, Mehdi; Akbarinejad, Vahid; Bagheri, Mohsen

    2015-03-01

    The aim of the present study was to compare intranasal (INS) and intramuscular (IM) routes of administration of a ketamine-midazolam combination in cats. Randomized block design. Twelve healthy mixed breed cats (six males and six females). The drug combination was ketamine (14 mg kg(-1) ) and midazolam (0.5 mg kg(-1) ). In the IM group, drugs were injected into quadratus femoris muscle; in the INS. group, the combination dropped equally into the two nostrils. Pulse and respiratory rates, peripheral haemoglobin oxygen saturation (SpO2 ) and rectal temperature were monitored before and at intervals after drug administration. Time to onset and duration of sedation and, during recovery to head up, sternal recumbency and recovery were recorded. There were no significant differences between the groups in any time measured except for recovery to sternal recumbency, where time was lower in the INS than in the IM (p = 0.034). Respiratory rate was greater in the INS than in the IM group (p = 0.029), but there was no difference between groups in other physiological parameters. In both groups SpO2 was low before and fell further during sedation. The results substantiated that INS ketamine-midazolam can produce effective sedation in cats. Intranasal (INS) administration of ketamine-midazolam is atraumatic, and its use may avoid the pain of injection of ketamine combinations when this drug is used to induce sedation in cats. © 2014 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia.

  3. Multidisciplinary rehabilitation following botulinum toxin and other focal intramuscular treatment for post-stroke spasticity.

    Science.gov (United States)

    Demetrios, Marina; Khan, Fary; Turner-Stokes, Lynne; Brand, Caroline; McSweeney, Shane

    2013-06-05

    Spasticity may affect stroke survivors by contributing to activity limitations, caregiver burden, pain and reduced quality of life (QoL). Spasticity management guidelines recommend multidisciplinary (MD) rehabilitation programmes following botulinum toxin (BoNT) treatment for post-stroke spasticity. However, the evidence base for the effectiveness of MD rehabilitation is unclear. To assess the effectiveness of MD rehabilitation, following BoNT and other focal intramuscular treatments such as phenol, in improving activity limitations and other outcomes in adults and children with post-stroke spasticity. To explore what settings, types and intensities of rehabilitation programmes are effective. We searched the Cochrane Stroke Group Trials Register (February 2012), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2011, Issue 12), MEDLINE (1948 to December 2011), EMBASE (1980 to January 2012), CINAHL (1982 to January 2012), AMED (1985 to January 2012), LILACS (1982 to September 2012), PEDro, REHABDATA and OpenGrey (September 2012). In an effort to identify further published, unpublished and ongoing trials we searched trials registries and reference lists, handsearched journals and contacted authors. We included randomised controlled trials (RCTs) that compared MD rehabilitation (delivered by two or more disciplines in conjunction with medical input) following BoNT and other focal intramuscular treatments for post-stroke spasticity with placebo, routinely available local services, or lower levels of intervention; or studies that compared MD rehabilitation in different settings, of different types, or at different levels of intensity. We excluded RCTs that assessed the effectiveness of unidisciplinary therapy (for example physiotherapy only) or a single modality (for example stretching, casting, electrical stimulation or splinting only). The primary outcomes were validated measures of activity level (active and passive function

  4. Um lugar para a Filosofia?

    Directory of Open Access Journals (Sweden)

    Samir Dessbesel Ferreira

    2010-01-01

    Full Text Available De que modo pode a Filosofia integrar-se às demais disciplinas da grade curricular dos cursos técnicos do IFSul? E como se insere uma disciplina como essa em instituições de ensino que têm tradicionalmente como foco o ensino tecnológico e profissionalizante, como são os Institutos Federais? Primeiramente, a Filosofia poderia contribuir na formação do profissional egresso, desenvolvendo-lhe competências relacionadas ao filosofar, em especial as relacionadas ao raciocínio abstrato e à comunicação, o que poderia vir a fazer a diferença no mercado de trabalho. Assim, os Institutos Federais ofereceriam um ensino de excelência com o objetivo de formar o técnico mais bem qualificado possível ao mercado de trabalho. Todavia, o aparelhamento técnico de nossos jovens, embora essencial para o desenvolvimento do País, não pode apresentar-se como a preocupação prioritária dos educadores, pois é fundamental considerar-se a formação integral da pessoa humana. Qual educação, afinal, queremos? E qual o papel da escola pública em nossa sociedade? O direcionamento unilateral à qualificação profissional pode levar-nos à formação de uma espécie de “superpeão”. A escola não pode ser serva do mercado. Ela tem o papel maior de agente de questionamento e transformação da sociedade. A concepção de Ensino Médio Técnico-Integrado nos parece orientar-se antes para a formação “integral” do cidadão, da pessoa em sua totalidade. O trabalho não é apenas uma relação econômica, mas também ética, política e estética. Deve ser uma forma de realização, de humanização do mundo, e não de coisificação do homem. É sempre possível pensar nossos espaços de educação formal como um compartilhar humano de sentidos, de afetos, de vivências, de posturas, de identidades. A esses espaços deverá a qualificação técnica sempre agregar-se, jamais sobrepor-se.

  5. Prehospital Agitation and Sedation Trial (PhAST): A Randomized Control Trial of Intramuscular Haloperidol versus Intramuscular Midazolam for the Sedation of the Agitated or Violent Patient in the Prehospital Environment.

    Science.gov (United States)

    Isenberg, Derek L; Jacobs, Dorian

    2015-10-01

    Violent patients in the prehospital environment pose a threat to health care workers tasked with managing their medical conditions. While research has focused on methods to control the agitated patient in the emergency department (ED), there is a paucity of data looking at the optimal approach to subdue these patients safely in the prehospital setting. Hypothesis This study evaluated the efficacy of two different intramuscular medications, midazolam and haloperidol, to determine their efficacy in sedating agitated patients in the prehospital setting. This was a prospective, randomized, observational trial wherein agitated patients were administered intramuscular haloperidol or intramuscular midazolam to control agitation. Agitation was quantified by the Richmond Agitation and Sedation Scale (RASS). Paramedics recorded the RASS and vital signs every five minutes during transport and again upon arrival to the ED. The primary outcome was mean time to achieve a RASS less than +1. Secondary outcomes included mean time for patients to return to baseline mental status and adverse events. Five patients were enrolled in each study group. In the haloperidol group, the mean time to achieve a RASS score of less than +1 was 24.8 minutes (95% CI, 8-49 minutes), and the mean time for the return of a normal mental status was 84 minutes (95% CI, 0-202 minutes). Two patients required additional prehospital doses for adequate sedation. There were no adverse events recorded in the patients administered haloperidol. In the midazolam group, the mean time to achieve a RASS score of less than +1 was 13.5 minutes (95% CI, 8-19 minutes) and the mean time for the return of normal mental status was 105 minutes (95% CI, 0-178 minutes). One patient required additional sedation in the ED. There were no adverse events recorded among the patients administered midazolam. Midazolam and haloperidol administered intramuscularly appear equally effective for sedating an agitated patient in the

  6. Os ruídos encontrados na construção de um modelo democrático e participativo de gestão hospitalar

    OpenAIRE

    Bernardes,Andrea; Cecílio,Luis Carlos de Oliveira; Nakao,Janete R. S.; Évora,Yolanda D. Martinez

    2007-01-01

    Um caminho para a modernização gerencial tem se pautado na perspectiva mais dialógica em torno da construção de um projeto de qualificação da assistência que tem como característica importante a ênfase na gestão colegiada em todos os níveis, a partir do conceito de co-gestão. O estudo visa avaliar quase dez anos de adoção do modelo colegiado de gestão em um hospital público do estado do Rio de Janeiro, buscando caracterizar se houve algum impacto na sua micropolítica. O objetivo da pesquisa é...

  7. Fatty rind of intramuscular soft-tissue tumors of the extremity: is it different from the split fat sign?

    Energy Technology Data Exchange (ETDEWEB)

    Sung, Jinkyeong; Kim, Jee-Young [The Catholic University of Korea, Departments of Radiology, St. Vincent' s Hospital, College of Medicine, Suwon, Gyeonggi-do (Korea, Republic of)

    2017-05-15

    To analyze intramuscular soft-tissue tumors with fatty rind, and to evaluate the difference between fatty rind and split fat sign on magnetic resonance imaging (MRI). We retrospectively analyzed 50 pathologically confirmed intramuscular masses on MRI. We evaluated the distribution and shape of fatty rind and muscle atrophy. Fatty rind was found more frequently in benign lesions (80% [36 out of 45]) compared with malignant lesions (25% [1 out of 5]; P = 0.013). Thirty-six benign lesions were peripheral nerve sheath tumors (PNSTs; n = 19), hemangiomas (n = 11), myxomas (n = 2), ganglion cysts (n = 2), giant cell tumor (n = 1), and leiomyoma (n = 1). One malignant lesion was a low-grade fibromyxoid sarcoma. In all masses with fatty rind, fat was confined to the proximal and the distal ends. In 12 cases, complete or partial circumferential fatty rind was also noted. Fatty rinds at both ends showed crescent, triangular, or combined shape. The prevalence of crescent-shaped fatty rind was significantly higher in benign PNST (17 out of 38) compared with the other tumors (1 out of 32; P < 0.001). Complete circumferential fat was noted only in hemangioma (n = 5). Triangular fatty rind was related to peripheral location of the mass or muscle atrophy. Most intramuscular tumors with fatty rinds were benign, and PNST was the most common tumor type. Fatty rind could be caused by displaced neurovascular bundle fat, fatty atrophy of the muscle involved, or intermuscular or perimysial fat. Crescent-shaped fatty rind was noted more frequently in benign PNSTs. (orig.)

  8. Treatment of agitation in the acute psychiatric setting. An observational study of the effectiveness of intramuscular psychotropic medication.

    Science.gov (United States)

    Bauer, Jeanett Østerby; Stenborg, Dina; Lodahl, Tue; Mønsted, Mik Mathias

    2016-11-01

    Agitation is frequent in the acute psychiatric setting. The observation and treatment of agitation is important to avoid harm to patients or staff, to reduce distress of the patient, and to reduce the risk of coercion, especially physical restraint. To evaluate the effect of intramuscular treatment with psychotropics on agitation in a non-selected acute psychiatric population. The Positive and Negative Syndrome Scale Excitement Component (PANSS-EC) was implemented in the acute psychiatric ward at Psychiatric Center Copenhagen to improve assessment and treatment of agitation. During a period of almost ~2 years the staff was requested to assess agitation before and after administration of intramuscular injections. PANSS-EC was obtained at baseline and within 2 hours after injection for 135 injections with antipsychotics or benzodiazepines administered to 101 acute, non-selected psychiatric patients with high occurrence of co-morbid substance abuse. Mean PANSS-EC at baseline was 26.53 ± 4.87, and mean reduction in PANSS-EC was 14.99 ± 8.48 (p patients were subjected to physical restraint. Patients subjected to restraint had a significantly higher PANSS-EC score. Patients who received a subsequent injection had a significantly lower decline in PANSS-EC score. Besides two cases of acute dystonia following haloperidol injections, no serious side-effects were observed. Treatment of agitation with intramuscular injections of psychotropics was in general effective in this non-selected, highly agitated psychiatric population, and injections were well tolerated.

  9. Increased technetium uptake is not equivalent to muscle necrosis: scintigraphic, morphological and intramuscular pressure analyses of sore muscles after exercise

    Science.gov (United States)

    Crenshaw, A. G.; Friden, J.; Hargens, A. R.; Lang, G. H.; Thornell, L. E.

    1993-01-01

    A scintigraphic technique employing technetium pyrophosphate uptake was used to identify the area of skeletal muscle damage in the lower leg of four runners 24 h after an ultramarathon footrace (160 km). Most of the race had been run downhill which incorporated an extensive amount of eccentric work. Soreness was diffuse throughout the posterior region of the lower leg. In order to interpret what increased technetium uptake reflects and to express extreme endurance related damages, a biopsy was taken from the 3-D position of abnormal uptake. In addition, intramuscular pressures were determined in the deep posterior compartment. Scintigraphs revealed increased technetium pyrophosphate uptake in the medial portion of the gastrocnemius muscle. For 3698 fibres analysed, 33 fibres (1%) were necrotic, while a few other fibres were either atrophic or irregular shaped. A cluster of necrotic fibres occurred at the fascicular periphery for one subject and fibre type grouping occurred for another. Ultrastructural analysis revealed Z-line streaming near many capillaries and variously altered subsarcolemmal mitochondria including some with paracrystalline inclusions. The majority of the capillaries included thickened and irregular shaped endothelial cells. Intramuscular pressures of the deep posterior compartment were slightly elevated (12-15 mmHg) for three of the four subjects. Increased technetium uptake following extreme endurance running does not just reflect muscle necrosis but also subtle fibre abnormalities. Collectively, these pathological findings are attributed to relative ischaemia occurring during the race and during pre-race training, whereas, intramuscular pressure elevations associated with muscle soreness are attributed to mechanical stress caused by extensive eccentric work during the race.

  10. Avoiding analgesic escalation and excessive healthcare utilization in severe irritable bowel syndrome: a role for intramuscular anticholinergics?

    Science.gov (United States)

    Pearson, James S; Pollard, Christine; Whorwell, Peter J

    2014-11-01

    In patients with severe irritable bowel syndrome (IBS), abdominal pain can be the predominant symptom impacting on all aspects of their lives and resulting in excessive healthcare utilization. Furthermore, the use of analgesics can become excessive in this group of patients, sometimes leading to opiate dependency. Typically, the pain is often described as spastic in nature and we have speculated that parenteral anticholinergics might provide effective relief when all other measures have failed. For several years, we have therefore been asking general practitioners to consider teaching such patients to administer intramuscular hyoscine butylbromide for pain episodes and this study is an audit of this approach. Patients in whom the use of intramuscular hyoscine butylbromide had been recommended to their general practitioner in the last three years were interviewed over the telephone in order to document the efficacy of this approach as well as any potential disadvantages. A total of 122 general practitioners were advised to try this approach, with 58 agreeing to teach the technique and prescribe the medication. Of the 58 patients who used the medication, 50 (86%) found it gave them pain relief, which was complete in six (10%), substantial in 36 (62%) and mild in eight (14%), with 15 (26%) decreasing the use of analgesics and 13 (32%) of the 41 taking opiates able to reduce or stop them completely. Side effects were few and largely consisted of those associated with anticholinergics. Only four patients stopped medication because of side effects and no major skin reactions were reported. The use of intramuscular hyoscine butylbromide shows promise in the management of IBS when severe unmanageable abdominal pain is a major problem. This approach appears to be safe and has the potential to reduce analgesic escalation, opiate dependency and attendances at accident and emergency departments.

  11. Improved neurological outcome by intramuscular injection of human amniotic fluid derived stem cells in a muscle denervation model.

    Directory of Open Access Journals (Sweden)

    Chun-Jung Chen

    Full Text Available The skeletal muscle develops various degrees of atrophy and metabolic dysfunction following nerve injury. Neurotrophic factors are essential for muscle regeneration. Human amniotic fluid derived stem cells (AFS have the potential to secrete various neurotrophic factors necessary for nerve regeneration. In the present study, we assess the outcome of neurological function by intramuscular injection of AFS in a muscle denervation and nerve anastomosis model.Seventy two Sprague-Dawley rats weighing 200-250 gm were enrolled in this study. Muscle denervation model was conducted by transverse resection of a sciatic nerve with the proximal end sutured into the gluteal muscle. The nerve anastomosis model was performed by transverse resection of the sciatic nerve followed by four stitches reconnection. These animals were allocated to three groups: control, electrical muscle stimulation, and AFS groups.NT-3 (Neurotrophin 3, BDNF (Brain derived neurotrophic factor, CNTF (Ciliary neurotrophic factor, and GDNF (Glia cell line derived neurotrophic factor were highly expressed in AFS cells and supernatant of culture medium. Intra-muscular injection of AFS exerted significant expression of several neurotrophic factors over the distal end of nerve and denervated muscle. AFS caused high expression of Bcl-2 in denervated muscle with a reciprocal decrease of Bad and Bax. AFS preserved the muscle morphology with high expression of desmin and acetylcholine receptors. Up to two months, AFS produced significant improvement in electrophysiological study and neurological functions such as SFI (sciatic nerve function index and Catwalk gait analysis. There was also significant preservation of the number of anterior horn cells and increased nerve myelination as well as muscle morphology.Intramuscular injection of AFS can protect muscle apoptosis and likely does so through the secretion of various neurotrophic factors. This protection furthermore improves the nerve

  12. Effect of different adjuvant formulations on the immunogenicity and protective effect of a live Mycoplasma hyopneumoniae vaccine after intramuscular inoculation.

    Science.gov (United States)

    Xiong, Qiyan; Wei, Yanna; Xie, Haidong; Feng, Zhixin; Gan, Yuan; Wang, Chunlai; Liu, Maojun; Bai, Fangfang; Xie, Fang; Shao, Guoqing

    2014-06-05

    Mycoplasma hyopneumoniae (M. hyopneumoniae) vaccine strain 168 is an intrapulmonically injected attenuated live vaccine that is available in the Chinese market. The aim of this study was to develop suitable adjuvants for this live vaccine to provide effective protection after intramuscular inoculation. Several adjuvant components were screened to assess their toxicity for the live vaccine, and various adjuvant formulations were then designed and prepared. Vaccines supplemented with these adjuvants were used to immunize mice intramuscularly to assess the capacity of the adjuvants to induce a specific immune response. The screened formulations were then evaluated in pigs. Seven of the eight adjuvant components did not affect the viability of the live vaccine, and seven different adjuvant formulations were then designed. In mice, the ISCOM-matrix adjuvant and the levamisole-chitosan mixture adjuvant significantly enhanced serum IgG responses against M. hyopneumoniae, while lymphocyte proliferation was enhanced by the ISCOM-matrix adjuvant, the carbomer-astragalus polysaccharide mixture adjuvant and an oil-in-water emulsion adjuvant. These four adjuvants were evaluated in pigs. Enhancement of specific lymphocyte proliferation responses was observed in the groups vaccinated with the ISCOM-matrix adjuvant and the carbomer-astragalus polysaccharide mixture adjuvant. Significant enhancement of serum IgG antibody production was observed before challenge in pigs vaccinated with the carbomer-astragalus polysaccharide mixture adjuvant and the levamisole-chitosan mixture adjuvant, while after challenge, all of the animals that received vaccines containing adjuvants had higher antibody concentrations against M. hyopneumoniae than unvaccinated animals. Animals inoculated with a vaccine containing the ISCOM-matrix adjuvant (median score 3.57) or the carbomer-astragalus polysaccharide mixture adjuvant (median score 5.28) had reduced lesion scores compared to unvaccinated animals

  13. Genetic variants in IL15 promoter affect transcription activity and intramuscular fat deposition in longissimus dorsi muscle of pigs.

    Science.gov (United States)

    He, D; Jiang, Z; Tian, Y; Han, H; Xia, M; Wei, W; Zhang, L; Chen, J

    2018-02-01

    Intramuscular fat (IMF) content is a key aspect of pork quality. Elucidation of intramuscular adipocyte regulation mechanisms is important for improving IMF content. Intramuscular adipocytes are dispersed among muscle fibers, so they are inclined to be affected by muscle-derived factors. Interleukin-15 is a major muscle-secreted factor. In this study, the genetic and physiological impacts of IL15 on adipogenesis is investigated. The promoter region of IL15 was scanned by comparative sequencing using two DNA pools of high- and low-IMF individuals. Two SNPs, c.-342C>T (ss2137497757) and c.-334G>A (ss2137497756) (the translation start site is designated as +1), were identified with reverse allele distribution in these two groups. Genotyping by allele-specific PCR revealed that the two SNPs were completely linked. The IMF content of TA/TA individuals was lower than that for CG/CG ones, whereas the IL15 expression level was higher in T-A/T-A individuals. Luciferase assaying also revealed that the T-A haplotype promoter had higher transcription activity. Meanwhile, the effect of interleukin-15 on adipocyte differentiation was further assessed in vitro. Results showed that interleukin-15 suppressed preadipocyte proliferation in a dose-dependent manner. The cell cycle of preadipocytes was arrested, and apoptosis was induced. Oil Red O staining and triglyceride quantification indicated that adipocyte differentiation was also inhibited by interleukin-15. The mRNA levels of PPARG and FABP4 decreased markably upon interleukin-15 treatment. Taken together, we identified two completely linked SNPs in the porcine IL15 promoter region that could alter IL15 transcription activity. As interleukin-15 can inhibit porcine adipocyte differentiation, these promoter mutations could affect IMF deposition by producing differential levels of muscle-derived interleukin-15. © 2017 Stichting International Foundation for Animal Genetics.

  14. Fatty rind of intramuscular soft-tissue tumors of the extremity: is it different from the split fat sign?

    International Nuclear Information System (INIS)

    Sung, Jinkyeong; Kim, Jee-Young

    2017-01-01

    To analyze intramuscular soft-tissue tumors with fatty rind, and to evaluate the difference between fatty rind and split fat sign on magnetic resonance imaging (MRI). We retrospectively analyzed 50 pathologically confirmed intramuscular masses on MRI. We evaluated the distribution and shape of fatty rind and muscle atrophy. Fatty rind was found more frequently in benign lesions (80% [36 out of 45]) compared with malignant lesions (25% [1 out of 5]; P = 0.013). Thirty-six benign lesions were peripheral nerve sheath tumors (PNSTs; n = 19), hemangiomas (n = 11), myxomas (n = 2), ganglion cysts (n = 2), giant cell tumor (n = 1), and leiomyoma (n = 1). One malignant lesion was a low-grade fibromyxoid sarcoma. In all masses with fatty rind, fat was confined to the proximal and the distal ends. In 12 cases, complete or partial circumferential fatty rind was also noted. Fatty rinds at both ends showed crescent, triangular, or combined shape. The prevalence of crescent-shaped fatty rind was significantly higher in benign PNST (17 out of 38) compared with the other tumors (1 out of 32; P < 0.001). Complete circumferential fat was noted only in hemangioma (n = 5). Triangular fatty rind was related to peripheral location of the mass or muscle atrophy. Most intramuscular tumors with fatty rinds were benign, and PNST was the most common tumor type. Fatty rind could be caused by displaced neurovascular bundle fat, fatty atrophy of the muscle involved, or intermuscular or perimysial fat. Crescent-shaped fatty rind was noted more frequently in benign PNSTs. (orig.)

  15. Analgesia pós-operatória com metadona em gatos: administração epidural e intramuscular

    Directory of Open Access Journals (Sweden)

    C.A. Bernardi

    2012-02-01

    Full Text Available Compararam-se os efeitos analgésico, sedativo e neuroendócrino decorrentes da administração epidural e intramuscular da metadona em gatas submetidas à ovariossalpingoisterectomia (OSH. Todos os animais foram tranquilizados com acepromazina, 0,1mg kg-1 IM, seguindo-se a indução e manutenção anestésica com tiopental sódico, 12mg kg-1 IV, e halotano, respectivamente. Após a estabilização anestésica, os animais foram distribuídos em três grupos, com oito animais cada, tratados com metadona pela via epidural (EP ou intramuscular (IM 0,2mg kg-1, respectivamente, ou com solução salina (S 0,2mL kg-1. Foram avaliados: graus de analgesia e de sedação, necessidade de analgesia de resgate, efeitos adversos e concentração sérica de cortisol. Os graus de analgesia e de sedação e o cortisol não diferiram entre os tratamentos. Analgesia de resgate foi administrada quatro, nove e 11 vezes nos tratamentos EP, IM e S, respectivamente. Nos tratamentos IM e S, a suplementação analgésica foi necessária a partir da primeira hora pós-cirúrgica, enquanto no tratamento EP, somente a partir da terceira hora após a OSH. Conclui-se que a administração de metadona pela via epidural resulta em menor quantidade do analgésico pós-operatório, e que a analgesia é mais prolongada quando comparada à obtida pela via intramuscular, em gatas submetidas à OSH.

  16. Single Intramuscular-dose Toxicity of Water soluble Carthmi-Flos herbal acupuncture (WCF in Sprague-Dawley Rats

    Directory of Open Access Journals (Sweden)

    Lee Hyung-geol

    2014-03-01

    Full Text Available Objectives: This experiment was conducted to examine the toxicity of WCF (Water soluble Carthmi-Flos herbal acupuncture by administering a single intramuscular dose of WCF in 6-week-old, male and female Sprague-Dawley rats and to find the lethality dose for WCF. Methods: The experiment was conducted at Biotoxtech according to Good Laboratory Practices under a request by the Korean Pharmacopuncture Institute. This experiment was performed based on the testing standards of “Toxicity Test Standards for Drugs” by the Ministry of Food and Drug Safety. Subjects were divided into 4 groups: 1 control group in which normal saline was administered and 3 test groups in which 0.1, 0.5 or 1.0 mL of WCF was administered; a single intramuscular dose was injected into 5 males and 5 females in each group. General symptoms and body weights were observed/measured for 14 days after injection. At the end of the observation period, hematological and clinical chemistry tests were performed, followed by necropsy and histopathological examinations of the injected sections. Results: No mortalities were observed in any group. Also, symptoms, body weight, hematology, clinical chemistry and necropsy were not affected. However, histopathological examination of the injected part in one female in the 1.0-mL group showed infiltration of mononuclear cells and a multi-nucleated giant cell around eosinophilic material. Conclusion: Administration of single intramuscular doses of WCF in 3 groups of rats showed that the approximate lethal dose of WCF for all rats was in excess of 1.0 mL, as no mortalities were observed for injections up to and including 1.0 mL.

  17. Comparative Pharmacokinetics, Tissue Distribution, Excretion of Recombinant Liver-Targeting Interferon with IFN α2b Administered Intramuscular in Rats.

    Science.gov (United States)

    Wang, Jie; Lu, Xuemei; Jin, Xiaobao; Zeng, Wenting; Zhu, Jiayong

    2015-01-01

    Interferon α2b (IFN α2b) is the first cytokine, which has been approved by FDA to treat chronic hepatitis B. However, it has no organ or tissue selectivity effect, and will be rapidly cleared out in the liver after the administration treatment. In our previous study, a novel liver-targeting fusion interferon (IFN-CSP) was constructed by recombining human IFN α2b with a CSP region I-plus peptide. The purpose of this study is to compare pharmacokinetics, tissue distribution, excretion of recombinant liver-targeting interferon IFN-CSP with IFN α2b following intramuscular administration in rats and estimate whether the fusion protein recombinant liver-targeting interferon has liver-targeting effect. Serum, tissue, urinary, fecal, and biliary concentrations of the drug were measured at various time points after administration using ELISA test. The pharmacokinetic character of IFN-CSP and IFNα2b was described using a non-compartmental model after a single intramuscular administration. Our results showed that there were no significant differences between these two drugs in pharmacokinetic and elimination. However, drug concentration of recombinant liver-targeting IFN was higher than IFN α2b in the liver after intramuscular administration in rats at different time points. It was increased in the spleen but not apparently, and decreased in the heart, lung and kidney. In conclusion, compared with traditional IFN α2b, the novel recombinant liver-targeting IFN will be more accumulated in the liver tissue. With this excellent property, IFN-CSP shows a great application prospect in clinical treatment, although further investigation is still needed.

  18. Changes in intramuscular fat, fatty acid profile and cholesterol content induced by zeranol implantation strategy in hair lambs.

    Science.gov (United States)

    Valenzuela-Grijalva, Nidia V; González-Rios, Humberto; Islava, Thalia Y; Valenzuela, Martin; Torrescano, Gastón; Camou, Juan P; Núñez-González, Francisco A

    2012-05-01

    The effect of zeranol implantation strategy on intramuscular fat, fatty acid profile and cholesterol content of the longissimus dorsi muscle of hair lambs was studied. Four treatments were tested: C, control group; Z12, 12 mg zeranol; Z24, 24 mg zeranol in a single application; and RZ12, 12 mg zeranol given twice. One-way analysis of variance was employed to estimate the effect of treatments (P content was observed from implanting (C1 effect) and zeranol reimplantation (C3 effect). Implanted lambs exhibited an increase (P content using a zeranol implantation strategy on hair lambs. Copyright © 2011 Society of Chemical Industry.

  19. Subacute fat-embolism-like syndrome following high-volume intramuscular and accidental intravascular injection of mineral oil

    DEFF Research Database (Denmark)

    Hjort, Mathias; Hoegberg, Lotte Christine Groth; Jansen, Tejs

    2015-01-01

    infiltrations. Suspecting pneumonia, the patient was discharged with antibiotics. Unkown to the clinicians, the patient had self-administered a mineral oil with added anabolic steroids by intramuscular injections for cosmetic purposes. The patient had observed blood on aspiration, and then relocated the needle......Objective. We present a rare case of subacute fat-embolism-like syndrome (FES-like) following intravascular injection of mineral oil-steroid solution with delayed diagnosis, acute onset of pulmonary distress, and transient clinical deterioration. Case report. A 40-year-old man was admitted...

  20. Histopathological study of local changes after intramuscular administration of cysteamine or its combination with mexamine in rats

    International Nuclear Information System (INIS)

    Resl, M.; Kuna, P.

    1984-01-01

    Local changes after intramuscular injection of cysteamine (50 mg x kg -1 ) and its mixture with mexamine (24 + 4 mg x kg -1 ) were studied in rats. Dystrophic changes in the muscle fibers with an exceptionally expressed complete necrosis were described. Regeneration and reparation of developed changes were observed on the 7th day after the protector injections. There were no qualitative differences after the injection of the cysteamine alone or combined with the mexamine. The results indicate that i.m. injection may be one of the possible modes of administration. (author)

  1. Umělá inteligence

    OpenAIRE

    Ragas, Luděk

    2017-01-01

    Cílem této bakalářské práce je poskytnout náhled do rozsáhlého oboru umělé inteligence. Téze nejprve poskytuje definici umělé inteligence a krátký přehled její historie. Poté práce stručně popisuje technologie umělé inteligence, jako jsou neuronové sítě, expertní systémy a genetické algoritmy. Na závěr téze popisuje vliv umělé inteligence na společnost a její pozici v ní. The aim of this bachelor thesis is to provide insight into the extensive field of artificial intelligence. At first, th...

  2. Mobilidade Social na Idade Média: um breve estudo sobre os ministeriales na Alemanha

    Directory of Open Access Journals (Sweden)

    José Henrique Rollo

    2013-10-01

    Full Text Available http://dx.doi.org/10.5007/2178-4582.2013v47n2p289 A imagem veiculada pelos manuais de história da sociedade europeia medieval como uma organização piramidal rígida usualmente negligencia alguns grupos sociais que experimentaram alguma forma de mobilidade social vertical. Um desses grupos foram os ministeriales ou dienstmänner, homens não-livres empregados pela Igreja e pela nobreza como burocratas e soldados. Embora tenham existido em diversos países, eles foram particularmente importantes na Alemanha dos séculos IX a XIII. Este artigo apresenta algumas de suas principais características como grupo social, analisa brevemente os padrões de mobilidade e expõe algumas das interpretações historiográficas a seu respeito.

  3. Um olhar neoinstitucionalista para o Programa Bolsa Família

    Directory of Open Access Journals (Sweden)

    Luísa de Azevedo Nazareno

    2015-03-01

    Full Text Available O Programa Bolsa Família (PBF é um programa de transferência condicionada de renda que vem sendo implementado no Brasil desde 2003 e atinge hoje milhões de famílias, tendo trazido inovações importantes tanto no desenho do programa como em sua gestão. Seus impactos sociais positivos têm sido amplamente discutidos pela literatura, contudo, o PBF também deve ser analisado sob o ponto de vista de inovações institucionais. Neste trabalho, partimos do neoinstitucionalismo histórico para discutir a gestão do PBF e algumas de suas inovações, tais como a criação do Cadastro Único e a gestão compartilhada e descentralizada.

  4. Hipovitaminose A no Brasil: um problema de saúde pública

    OpenAIRE

    Ramalho Rejane Andréa; Flores Hernando; Saunders Cláudia

    2002-01-01

    A deficiência de vitamina A é considerada um dos problemas de saúde pública de fácil prevenção mais importantes em diversos países, inclusive o Brasil. Assim, o objetivo do presente trabalho foi revisar a literatura sobre carência de vitamina A publicada entre 1970 e 2000, disponível nas bases de dados MEDLINE e LILACS, e avaliar a hipovitaminose A na América Latina e no Brasil. A pesquisa revelou que até os anos 1980, a atenção dada pela saúde pública à vitamina A se concentrou na importânci...

  5. UM TRATADO PARA O AMOR

    Directory of Open Access Journals (Sweden)

    Maria José Caldeira do Amaral

    2015-07-01

    Full Text Available No Tratado do Amor Cortês - Tractatus de Amore - André Capelão deseja oferecer ao leitor a arte cortês de amar, a beleza do desejo erótico e a disciplina da paixão constitutiva dessa arte que é amar. O maior argumento dessa obra é efetivar o suspiro fundo que a dimensão amorosa infunde na alma do homem e da mulher aos quais foi concedida a virtude. Para esse autor, escriba da chancelaria real e talvez, não se sabe com certeza, um Ordo Sacratus, o amor é a raiz de toda cortesia, a fonte de todo bem. Nosso objetivo, então, é encontrar nessa suma amorosa construída nos enlaces da Literatura de Cavalaria Medieval, os desdobramentos essenciais dessa vida afetiva bela e virtuosa no enredo profundo do qual emerge o afeto, a fé e a contradição da experiência humana do sofrimento amoroso. Palavras Chave: Literatura Medieval. Amor Cortês, André Capelão, virtude, desejo. Abstract: With the treaty toward the love - Tractatus de Amore – André Capelão offers to the reader the courteous’ art for love, the erotic desire’s beauty and the  suffering discipline belong this love’s art  is. The best reason of this literary composition is to achieve the depth sigh that the loving dimension infuses into the lovers’s soul, the man and the woman wich this virtue was conceded. For this author, the royal chancery scribe and perhaps, no one knows for sure, a Sacratus Ordo, love is the root of all free, the source of all good. Our goal, then, is to find this sum loving built in interlacing of Medieval Knights literature, the essential developments of this beautiful and virtuous love life in the deep storyline which emerges affection, faith and the contradiction of the human experience of love suffering. Key words: Medieval Literature. Courteous Love. André Capelão. Virtue.

  6. [Arthroscope monitored solution of adult intramuscular injection associated gluteal muscle contracture by radiofrequency].

    Science.gov (United States)

    Liu, Yu-Jie; Xue, Jing; Zhou, Mi; Wang, Zhi-Gang; Li, Zhong-Li; Cai, Xu; Wei, Min; Wang, Yan; Zhu, Juan-Li

    2008-07-01

    To evaluate the result of releasing adult intramuscular injection associated gluteal muscle contracture under the monitor of arthroscope by radiofrequency probe. From June 2001 to June 2005, 108 cases of bilateral gluteal muscle contracture were treated with radiofrequency colation under the arthroscope and solution with an average age of 24 years (from 18 to 40 years). There were 57 males and 51 females. Preoperatively, the course of the outline of the femur greater trochanter the sciatic nerve in buttocks and the area of gluteal muscle contracture were marked. With the patients firmly anchored in the straight lateral position, normal saline (which contains Adnephrin) was injected between the surface of contracted gluteus and subcutaneous fat to reduce bleeding in operation. The ports for the motorized shaver and radiofrequency probe were located at the edge of gluteal muscle contracture and were 5 mm superior to the greater trochanter. The 6 mm diameter port for the arthroscope was 3 cm inferior to the greater trochanter. Space was made between contracture bands and overlying subcutaneous tissue with a periosteal elevator by blunt dissection. After the anterior and posterior edge of the contracture bands were fully revealed, normal saline were filled in the space. With the monitor of arthroscope, the procedures were: removing fatty tissue from the surface of the contracture bands with motorized shaver, then cutting off the contracture bands curve and carefully probing and cutting off contracture bands which were mixed in gluteus maximus with radiofrequency probe, finally hemostasis by radiofrequency probe. In the operation flexion, adduction, internal rotation and straightening hip joint were repeated, until it got normal range of motion without snap and bleeding. Results One hundred and one patients were followed up with an average of 19 months. According to a comprehensive evaluating system, 91 cases were excellent, 7 were good, and 3 were fair. No infection

  7. Intramuscular versus Intraosseous Delivery of Nerve Agent Antidote Pralidoxime Chloride in Swine.

    Science.gov (United States)

    Uwaydah, Nabeel I; Hoskins, Stephen L; Bruttig, Stephen P; Farrar, Henry; Copper, Nick C; Deyo, Donald J; Dubick, Michael A; Kramer, George C

    2016-01-01

    Exposure to nerve agents requires prompt treatment. We hypothesized that intraosseous (IO) injections of drug antidotes into the vascularized bone marrow will provide a more rapid and effective means to treat exposure to nerve agents than standard intramuscular (IM) injections. We compared the pharmacokinetics of IM and IO administration of pralidoxime chloride (2-PAM Cl) during normovolemia and hypovolemia, as well as their combined administration during normovolemia in swine. Ten normovolemic swine were randomly administered 2 mL, 660 mg 2-PAM Cl via the IM or IO route and monitored for 180 minutes. IM versus IO also was compared in 8 hypovolemic swine bled to a mean arterial pressure of 50 mmHg. In a combined group, an IO injection was administered followed by an IM injection 60 minutes later. Blood samples were collected at times over a 180-minute period to calculate standard pharmacokinetic variables to compare the 2 routes of administration. In the normovolemic swine, IM injection achieved therapeutic levels (4 μg/mL) in 2 minutes, whereas IO infusion achieved these levels in less than 15 seconds. 2-PAM-Cl concentrations fell below these levels at 60 minutes post-injection in both groups. In the hypovolemic swine, IM injection achieved therapeutic levels in 4 minutes compared to less than 15 seconds in the IO group. 2-PAM-Cl concentrations fell below therapeutic levels at 12 and 90 minutes post-injection in the IM and IO groups, respectively. In the combined IO-IM treatment, plasma levels remained above therapeutic levels for the entire experiment and had two concentration peaks that corresponded to IO and IM injections. The IO route for the delivery of 2-PAM Cl provides a significant time and high initial blood concentrations advantage compared to the IM route for the prehospital treatment of nerve agent exposure even under hypovolemic conditions. The initial concentration peak associated with IO, but not IM, may provide greater initial therapy at the

  8. Intramuscular long-acting paliperidone palmitate in acute patients with schizophrenia unsuccessfully treated with oral antipsychotics.

    Science.gov (United States)

    Hargarter, Ludger; Cherubin, Pierre; Bergmans, Paul; Keim, Sofia; Rancans, Elmars; Bez, Yasin; Parellada, Eduard; Carpiniello, Bernardo; Vidailhet, Pierre; Schreiner, Andreas

    2015-04-03

    In this prospective multicentre, open-label, 6-month study (Paliperidone Palmitate Flexible Dosing in Schizophrenia [PALMFlexS]), tolerability, safety and treatment response with paliperidone palmitate (PP) were explored in patients with acute symptoms of schizophrenia following switching from previously unsuccessful treatment with oral antipsychotics. This pragmatic study was conducted in a large, more representative sample of the general schizophrenia population compared to randomized controlled pivotal trials, to specifically mimic real-world clinical situations. After initiation on Day 1 and Day 8, patients received PP once monthly at flexible doses (50-150mgeq.) intramuscularly. The primary efficacy outcome was defined as the percentage of patients achieving ≥30% improvement in PANSS total score from baseline (BL) to last-observation-carried-forward (LOCF) endpoint (EP). Safety and tolerability assessments included Extrapyramidal Symptom Rating Scale (ESRS) total score and treatment-emergent adverse events (TEAEs). Overall, 212 patients received PP at least once after switching from oral antipsychotics, primarily due to lack of efficacy (45.8%). Significant improvements from BL in mean (SD) PANSS total score were observed from Day 8 onwards (BL to LOCF EP: -31.0 [29.0]; p<0.0001). At endpoint, two-thirds (66.7%) and 43.5% of patients achieved a ≥30% and ≥50% improvement in mean PANSS total score, respectively. PP was associated with significant improvements across secondary measures of symptom severity, subjective well-being, medication satisfaction, illness-related disorders of activity and participation, and patient functioning (p<0.0001; BL to LOCF EP). PP was generally well tolerated, with significant reductions in ESRS total score (p<0.0001) and mainly mild-to-moderate TEAEs. TEAEs reported in ≥5% of patients were injection-site pain (13.7%), insomnia (10.8%), psychotic disorder (10.4%), headache and anxiety (both 6.1%). The PALMFlexS study

  9. Virosomal hepatitis a vaccine: comparing intradermal and subcutaneous with intramuscular administration.

    Science.gov (United States)

    Frösner, Gert; Steffen, Robert; Herzog, Christian

    2009-01-01

    Vaccination against hepatitis A virus (HAV) is unaffordable to many developing countries. Substantial reductions in cost occur when vaccines are administered intradermally at low doses. Aluminum-free HAV vaccines are considered more suitable for intradermal use than traditional vaccines which can cause long-lasting local reactions. Thus, we compared the immunogenicity and safety of an aluminum-free virosomal HAV vaccine (Epaxal) administered by different routes: intradermal (i.d.), subcutaneous (s.c.), and intramuscular (i.m.). Two open pilot studies were conducted as sub-studies of a large lot consistency trial. Healthy subjects aged 18 to 45 were enrolled. Study 1 compared two i.d. regimens of a lower dose of Epaxal [0.1 mL (4.8 IU), one or two injection sites] with i.m. administration of the standard dose [0.5 mL (24 IU)]. Study 2 compared the s.c. with the i.m. administration of the standard dose. At month 12, subjects in study 1 received a booster dose of 0.1 mL i.d. or 0.5 mL i.m.; subjects in study 2 received 0.5 mL via the respective route (s.c. or i.m.). Serum was tested for antibodies at baseline, 2 weeks (study 1), and 1 and 6 months after the primary vaccination as well as prior and 1 month after the booster dose. Incidences of solicited and unsolicited adverse events were recorded. Seroprotection rates (anti-HAV geometric mean concentration of > or =20 mIU/mL) after 1 month ranged from 93.2% to 100% in all groups and remained high until month 12 (range 85.2&-90.2%). Complete (100%) seroprotection was achieved by all subjects in all groups after booster vaccination. All routes of administration were well tolerated. Local reactions were more common in subjects vaccinated i.d. and s.c. than i.m. The aluminum-free virosomal HAV vaccine Epaxal is highly immunogenic and well tolerated when administered either via i.d., s.c., or i.m. Vaccination via the i.d. route may confer significant cost savings over the conventional i.m. route.

  10. Pharmacokinetics of butorphanol after intravenous, intramuscular, and oral administration in Hispaniolan Amazon parrots (Amazona ventralis).

    Science.gov (United States)

    Guzman, David Sanchez-Migallon; Flammer, Keven; Paul-Murphy, Joanne R; Barker, Steven A; Tully, Thomas N

    2011-09-01

    Previous studies have validated the clinical use of opioids with kaap-receptor affinities for pain management in birds. Butorphanol, a kappa opioid receptor agonist and a mu opioid receptor antagonist, is currently considered by many clinicians to be the opioid of choice for this use. However, despite studies reporting the analgesic properties of butorphanol in psittacine birds, dosing intervals have not been established for any psittacine species. The goals of this study in the Hispaniolan Amazon parrot (Amazona ventralis) were to evaluate the pharmacokinetics of butorphanol tartrate after intravenous (IV), intramuscular (IM), and oral (PO) administration and to determine the bioavailability of butorphanol tartrate after oral administration. Twelve Hispaniolan Amazon parrots were used in the study, with a complete-crossover experimental design and a 3-month period separating each part of the study. The birds were randomly assigned to 3 groups (n = 4) for each stage. Butorphanol tartrate was administered once at a dose of 5 mg/kg in the basilic vein or pectoral muscles or as an oral solution delivered via feeding tube into the crop for the IV, IM, and PO studies, respectively. After butorphanol administration, blood samples were collected at 1, 5, 15, 30, 60, 90, 120, 180, and 240 minutes for the IV and IM studies and at 5, 15, 30, 60, 90, 120, 180, 240, and 300 minutes for the PO study. Because of the size limitation of the birds, naive pooling of datum points was used to generate a mean plasma butorphanol concentration at each time point. For each study, birds in each group (n = 4) were bled 3 times after dosing. Plasma butorphanol concentrations were determined by high-performance liquid chromatography/tandem mass spectrometry, and pharmacokinetic parameters were calculated. Butorphanol tartrate was found to have high bioavailability and rapid elimination following IM administration. In contrast, oral administration resulted in low bioavailability (< 10%), thus

  11. Expression profiles and associations of adiponectin and adiponectin receptors with intramuscular fat in Tibetan chicken.

    Science.gov (United States)

    Zhang, R; Lin, Y; Zhi, L; Liao, H; Zuo, L; Li, Z; Xu, Y

    2017-04-01

    1. Adiponectin and its receptors (ADIPOR1 and ADIPOR2) are novel endocrine systems that act at various levels to modulate glucose and lipid metabolism. This study was designed to investigate the spatial expression of adiponectin, ADIPOR1 and ADIPOR2 genes in various tissues in Tibetan chicken. The temporal expression of adiponectin and its receptor mRNAs were also studied in adipose tissue, breast muscle and thigh muscle and the correlations of the levels of adiponectin, ADIPOR1 and ADIPOR2 mRNA with the contents of intramuscular fat in breast muscle and thigh muscle of Tibetan chicken were determined. 2. Quantitative real-time PCR detected chicken adiponectin, ADIPOR1 and ADIPOR2 mRNA transcripts in heart, liver, spleen, lung, kidney, skeletal muscle and adipose tissue. 3. Adipose tissue contained the highest amount of adiponectin mRNA followed by the kidney and liver. The expression levels of ADIPOR1 mRNA were significantly higher in adipose tissue, lung and spleen, and adipose tissue exhibited significantly higher levels of ADIPOR2 mRNA followed by the spleen and lung compared with other tissues. 4. Temporal expression profiles of adiponectin, ADIPOR1 and ADIPOR2 mRNA showed gender differences in adipose tissue and skeletal muscle at certain ages. In adipose tissue, adiponectin mRNA was higher in 154-d-old females and ADIPOR1 mRNA was higher in 154-d-old males: Adiponectin and ADIPOR2 mRNA were higher, and ADIPOR1 mRNA was lower, in thigh muscle in female compared with male chickens. 5. The correlation data showed that, except for adiponectin mRNA, the levels of ADIPOR1 and ADIPOR2 mRNA in thigh muscle of males were significantly positively correlated with IMF (r = 0.206 for the ADIPOR1 gene and r = 0.676 for the ADIPOR2 gene). 6. Taken together, it was concluded that adiponectin and the ADIPOR1 and ADIPOR2 genes are ubiquitously expressed in various tissues of Tibetan chicken and the expression of the adiponectin system is gender-dependant at certain ages

  12. Muscle lipid metabolism in two rabbit lines divergently selected for intramuscular fat.

    Science.gov (United States)

    Martínez-Álvaro, M; Agha, S; Blasco, A; Hernández, P

    2017-06-01

    A divergent selection experiment for intramuscular fat (IMF) of LM at 9 wk of age was performed in rabbits. The objective of this work was to compare the lipid metabolism in muscles and fat tissues of the high-IMF and low-IMF lines. Lipogenic, catabolic, and lipolytic activities were studied in 2 muscles with different oxidative patterns (LM and semimembranosus proprius) and in the perirenal fat depot at 2 ages, 9 and 13 wk. In addition, adipocytes were characterized in perirenal fat. In the fifth generation, direct response to selection was 0.26 g IMF/100 g muscle. Lines showed differences in their lipogenic activities of muscles and fat tissues at 13 wk but not at 9 wk. The high-IMF line showed greater glucose-6-phosphate dehydrogenase (G6PDH), malic enzyme (EM), and fatty acid synthase (FAS) activities in LM than the low-IMF line, with probabilities = 1.00, 0.93, and 0.90, respectively. Differences between lines were particularly great for G6PDH activity, representing 1.13 SD. The high-IMF line also showed greater G6PDH and FAS activities in semimembranosus proprius (P = 0.98 for G6PDH and 0.95 for FAS) and perirenal fat (P = 0.91 for G6PDH and 0.96 for FAS). However, in perirenal fat, EM activity was greater in the low-IMF line (P = 0.90). No differences between lines were found in almost any catabolic or lipolytic activities of muscles. Regarding adipocyte characteristics, the high-IMF line showed larger adipocytes in perirenal fat depot tissue (P = 0.97) compared to the low-IMF line, but no differences between lines were observed in the number of adipocytes. This study sheds light on the metabolic activities involved in the genetic differentiation of lipid deposition in rabbits. This study shows that lipogenic activities in muscles and fat tissues, in particular G6PDH in LM, are involved in the lipid accumulation in muscle and adipose tissues.

  13. TRIENNIAL GROWTH AND DEVELOPMENT SYMPOSIUM: Factors influencing bovine intramuscular adipose tissue development and cellularity.

    Science.gov (United States)

    Albrecht, E; Schering, L; Liu, Y; Komolka, K; Kühn, C; Wimmers, K; Gotoh, T; Maak, S

    2017-05-01

    Appearance, distribution, and amount of intramuscular fat (IMF), often referred to as marbling, are highly variable and depend on environmental and genetic factors. On the molecular level, the concerted action of several drivers, including hormones, receptors, transcription factors, etc., determines where clusters of adipocytes arise. Therefore, the aim of future studies remains to identify such factors as biological markers of IMF to increase the ability to identify animals that deposit IMF early in age to increase efficiency of high-quality meat production. In an attempt to unravel the cellular development of marbling, we investigated the abundance of markers for adipogenic differentiation during fattening of cattle and the transcriptome of muscle and dissected IMF. Markers of different stages of adipogenic differentiation are well known from cell culture experiments. They are usually transiently expressed, such as delta-like homolog 1 (DLK1) that is abundant in preadipocytes and absent during differentiation to mature adipocytes. It is even a greater challenge to detect those markers in live animals. Within skeletal muscles, hyperplasia and hypertrophy of adipocytes can be observed throughout life. Therefore, development of marbling requires, on the cellular level, recruitment, proliferation, and differentiation of adipogenic cells to store excess energy in the form of lipids in new cells. In a recent study, we investigated the localization and abundance of early markers of adipogenic differentiation, such as DLK1, in bovine muscle tissue. An inverse relationship between IMF content and number of DLK1-positive cells in bovine muscle was demonstrated. Considering the cellular environment of differentiating adipocytes in muscle and the secretory action of adipocytes and myocytes, it becomes obvious that cross talk between cells via adipokines and myokines may be important for IMF development. Secreted proteins can act on other cells, inhibiting or stimulating

  14. Pharmacokinetics of dexmedetomidine combined with methadone following oral-transmucosal and intramuscular administration in dogs

    Directory of Open Access Journals (Sweden)

    Federica Di Cesare

    2017-05-01

    Full Text Available Oral-transmucosal (OTM drug delivery refers to noninvasive and painless administration of medical preparations through any oral cavity membrane to achieve systemic effects (Sattar et al., 2014. Regarding sedative drugs, OTM administration is very attractive in veterinary medicine, especially for patients difficult to inject and restrain (Messenger et al., 2016. This study aims to compare the pharmacokinetics of dexmedetomidine after OTM and intramuscular (IM administration combined with methadone. After obtaining Ethical Committee approval and owner’s written consent, eight dogs, were administered with dexmedetomidine (10 mg/kg and methadone (0.4 mg/kg by OTM and other 4 dogs by IM route. Blood samples were collected at prefixed times up to four hours. Dexmedetomidine was quantified by a validated HPLC-MS method. On dexmedetomidine concentrations, a pharmacokinetic analysis was carried out with a noncompartmental approach (Phoenix WinNonlin® 7.0, Pharsight, Cary, NC. Mean ± SD terminal half-lives of dexmedetomidine were 187.42 ± 109.66 and 94.78 ± 34.08 min after OTM and IM administration, respectively. Maximum serum (Cmax concentrations were 0.83 ± 0.32 and 9.09 ± 2.46 ng/mL for OTM and IM administration, respectively. Time to maximum concentration (Tmax were 44.38 ± 32.16 and 21.25±11.39 min by OTM and IM administration, respectively. Area under the curve from 0 to the last measured concentration (AUClast were 103.75 ± 30.23 and 614.87 ± 77.15 min*ng/mL for OTM and IM administration, respectively. Cmax, Tmax and AUClast values by OTM route demonstrate a lower and delayed absorption of the drug compared to IM. To complete the study, the pharmacokinetic analysis of methadone is foreseen, so as a clinical trial to compare the clinical effects of the combination of dexmedetomidine and methadone by OTM and IM administration and to establish an effective dosage of oral-transumucosal route in dogs for this association.

  15. EDUCAÇÃO E SOFRIMENTO: MARCAS DE UM PARADIGMA

    Directory of Open Access Journals (Sweden)

    Nize Campos Pellanda

    2008-07-01

    Full Text Available Com essa comunicação pretendemos apresentar um relato de uma pesquisa em andamento sobre sofrimento dos estudantes como consequência de práticas educativas que não contemplam necessidades fundamentais dos seres humanos em termos biológicos, epistêmicos e ontológicos. Essas necessidades estão sendo apontadas por pesquisas transdisciplinares recentes sobre o funcionamento dos seres vivos. Essas práticas didáticas são consideradas na pesquisa como altamente inibidoras do ser/conhecer. Essa inseparabilidade das dimensões da realidade é a marca principal da investigação pautada no paradigma da complexidade fazendo contraponto com as questões da fragmentação da modernidade que representam um foco importante de análise. O quadro teórico de fundo para análise dos dados é construído a partir de ciências que constituem o movimento de auto-organização (MAO focalizando principalmente as teorias biológico/cognitivas da Biologia do Conhecer de H. Maturana e F. Varela e Complexificação pelo ruído de H. Atlan. Os dados referem-se a duas fontes principais de coleta: conversas com crianças de 5ª a 8ª séries do Ensino Fundamental de escolas estaduais de duas cidades diferentes e depoimentos de educadores em forma de história de vida. Nessa apresentação serão discutidos apenas os dados referentes à primeira parte pois a segunda parte ainda não foi analisada. Esclarecemos que trata-se de uma pesquisa em andamento e, por esse motivo, não aparecerão aqui situações conclusivas mas sim uma ênfase no devir da pesquisa. A partir desse quadro teórico, são feitas as análises cujo eixo situa-se na questão da (nãoconstrução de sentido na escola. Usamos sentido como aquilo que emerge da ação humana e, portanto, como produção dos seres humanos no bojo de sua ação sobre a realidade. Nessa perspectiva, ele faz parte integrante do processo de conhecimento que, por sua vez, não se separa do processo de viver. Palavras

  16. Fatores Determinantes da Aprendizagem Organizacional para a Inovação Ambiental: Um Estudo Multicaso

    Directory of Open Access Journals (Sweden)

    Rafael Ricardo Jacomossi

    2017-09-01

    Full Text Available Conforme as questões ambientais orientam as ações das empresas por meio de sua agenda de inovação, a aprendizagem organizacional surge como importante elemento de análise. Sugere-se que as noções de aprendizagem organizacional e aprendizagem para a sustentabilidade devam convergir, estabelecendo-se como antecedentes do próprio processo de inovação ambiental e denotando, a partir deste ponto, um novo campo de análise – o da Aprendizagem Organizacional para a Inovação Ambiental. Este trabalho tem como objetivo identificar os indutores que determinam a aprendizagem organizacional para a inovação ambiental. Para tanto, foi elaborado um modelo conceitual de análise que foi aplicado por meio de um estudo multicaso em três empresas. Das diversas variáveis analisadas, a regulação, o papel do empreendedor, o trabalho de Pesquisa & Desenvolvimento (P&D em redes e a existência de um processo de gestão ambiental se mostraram influentes para a consolidação do processo de aprendizagem. Infere-se que as influências das variáveis do processo de aprendizagem organizacional para a inovação ambiental diferem quanto à intensidade em função do modelo de negócio adotado, do grau de autonomia dos gerentes, do tipo de educação ambiental recebido pelos funcionários, do ambiente cultural e do perfil do empreendedor.

  17. Transtorno afetivo bipolar: um enfoque transcultural

    OpenAIRE

    Sanches,Marsal; Jorge,Miguel Roberto

    2004-01-01

    Considerando-se que existem diferenças importantes na maneira como as emoções são vivenciadas e expressas em diferentes culturas, a apresentação e o manejo do transtorno afetivo bipolar sofrem influência de fatores culturais. O presente artigo realiza uma breve revisão da evidência referente aos aspectos transculturais do transtorno bipolar.

  18. Organização de Reparo na Conversa Cotidiana: um Estudo Empírico

    Directory of Open Access Journals (Sweden)

    Caroline Caputo Pires

    2017-02-01

    Full Text Available O presente trabalho visa analisar ocorrências de trajetórias de reparo com dados em fala-em-interação em uma filmagem com quatro brasileiros intercambistas na Alemanha, no qual apresentam suas experiências no período de um ano em contato com outra língua e cultural. Assim, para descrever o fenômeno de reparo (SIDNELL, 2010, GARCEZ, 2008, LODER, 2005 é importante destacar que os participantes em interação e demonstrável pela articulação de análises comunicacionais, o fenômeno do reparo é importante para a interpretação em relação à correção na fala-em-interação, na medida em que o reparo se refere às práticas que participantes usam para contornar problemas ou obstáculos na fala, audição ou compreensão da fala. Enfatiza-se, nesse trabalho, que os estudos sobre reparo na fala-em-interação se deram no campo dos estudos da Análise da Conversa, entre estudiosos que se interessam nas ações cotidianas na vida das pessoas. Dessa forma, a base empírica desse trabalho focalizará os conceitos da Análise da Conversa, fenômenos de reparo em uma filmagem de uma interação de brasileiros em intercambio no ano de 2014. Os dados empíricos fazem parte do projeto da UFMG que investiga perspectivas comunicativas e as atitudes extracomunicativas que indivíduos realizam e desenvolvem no decorrer de um encontro intercultural de duração maior.

  19. Um casamento feliz: direito internacional e sociedade civil global na formação dos regimes internacionais

    Directory of Open Access Journals (Sweden)

    Ana Paula Tostes

    2006-11-01

    Full Text Available O artigo tem o objetivo de demonstrar a relação entre o aumento da sociedade civil global e o Direito internacional público, por um lado e, por outro, a importância dos regimes internacionais para a perspectiva da participação de atores não-estatais nas relações internacionais. O debate na literatura sobre regimes internacionais aponta para a necessidade de realizarem-se mais pesquisas empíricas sobre os condicionantes do sucesso dos regimes internacionais, porém já é possível destacar evidências a respeito de um importante papel que vem sendo ocupado por atores não-soberanos na formação de regimes: o papel de especialistas. O artigo é uma reflexão sobre o conceito de "regime internacional" e seus limites e apresenta uma nota preliminar de pesquisa sobre as possibilidades da influência de atores da sociedade civil na busca da formação de um regime internacional de meio ambiente, com destaque na participação do Brasil no processo de formulação de um regime de biosseguranca.

  20. Um Processador Rápido de Corte em Momento Transverso para o Trigger da Experiência CP-LEAR

    CERN Document Server

    Machado, Emanuel Tito Mendes

    Neste trabalho pretendemos mostrar alguns aspectos importantes no desenho de instrumentação para sistemas de selecção de eventos (trigger), que se revelaram importantes no desenho do sistema de trigger de CP–LEAR. Para isso, fazemos um zoom progressivo sobre a experiência. Começamos por mostrar o que são sistemas de trigger, quais as suas propriedades e diversidade, e que tipos de sistemas são usados e em que circunstâncias. É também feito um apanhado do state of the art dos diversos componentes e soluções utilizadas para a resolução dos problemas típicos destes sistemas. A seguir, apresentamos CP–LEAR, descrevendo a física em que se apoia o seu método. Aqui introduzimos o conceito de simetrias, e em que circunstâncias podemos falar de violação de simetria. Seguidamente, introduzimos o sistema de kaões neutros, apresentamos o fenómeno de violação CP, e descrevemos o método de CP–LEAR utilizado para o seu estudo. Depois de apresentar o detector utilizado na experiência, começa...