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Sample records for interviews as topic

  1. Interview "Problems" as Topics for Analysis

    Science.gov (United States)

    Roulston, Kathryn

    2011-01-01

    In this article the author argues that interactional difficulties and questioning practices identified in the methodological literature on qualitative interviewing as "problems" provide topics of analysis. Methodological examinations of interview data drawing on conversation analysis also explicate how interview "problems" may be conceptualized in…

  2. Interviews concerning topical questions in nuclear technology

    International Nuclear Information System (INIS)

    Segatz, U.; Schatz, A.; Stephany, M.; Michaelis, H.

    1978-01-01

    On the occasion of the Nuclex meeting, October 3-7, 1978, Basle/Switzerland, the editorial department of 'Atom und Strom' questioned some leading scientists in nuclear technology on particularly relevant topics. The following subjects were discussed: - How long can we do without nuclear energy, - Modern technology for nuclear power plants, - Nuclear fuel cycle and environment, - Nuclear energy and European Communities, - Nuclear energy and its risks (reflections on incidents). (orig./UA) [de

  3. Interview as intraviews

    DEFF Research Database (Denmark)

    Petersen, Kit Stender

    2014-01-01

    In this article I will illustrate how our understanding of the interview situation changes when we rethink it with some of the concepts from Karen Barad’s notion of agential realism. With concepts such as ‘apparatuses’, ‘phenomena‘, ‘intra-action’ and ‘material-discursive’ (Barad, 2007) it become...... the children’s ways of responding to my questions and re-negotiated the positions of interviewer and interviewee....... possible to focus more extensively on how matter matters in the interview situation. Re-thinking the interview as an intraview1, I argue that Barad’s concepts will enhance our awareness not only of how the researcher affects the interview but also of how certain kinds of materiality in interview situations...... do not merely refer to passive entities but must be understood as matter that matters. To illustrate my points I will analyse how bringing a puppet with me to interviews with 4-6 year old children seemed to interfere with the interview situation creating unforeseen diversions in ways that influenced...

  4. Researcher or nurse? Difficulties of undertaking semi-structured interviews on sensitive topics.

    Science.gov (United States)

    Ashton, Susan

    2014-09-01

    To reflect on the author's personal and professional journey when undertaking semi-structured interviews on sensitive topics with potentially vulnerable people. When discussing care at the end of life, researchers must accept that some participants may become distressed or emotional, depending on their previous experiences. Interviews that involve sensitive topics require careful planning. The semi-structured interviews were conducted as part of the author's PhD study examining the experiences of advance care planning among family caregivers of people with advanced dementia. A reflection on my personal and professional journey when undertaking semi-structured interviews on sensitive topics with potentially vulnerable people. The frustration and tragedy of dementia, as experienced by the family caregivers, were powerful and required the author to exert self-control to avoid being overly sympathetic and offering words of reassurance, agreement and comfort. This blurring of roles between researcher and nurse has implications for all nurse researchers who undertake qualitative interviews, particularly when an intense emotional response is likely. Nurse researchers should plan and prepare for potential blurring of roles during emotional interviews and should never automatically assume that they are sufficiently prepared as a result of their previous experience and nurse training.

  5. Methodological and ethical issues related to qualitative telephone interviews on sensitive topics.

    Science.gov (United States)

    Mealer, Meredith; Jones Rn, Jacqueline

    2014-03-01

    To explore the methodological and ethical issues of conducting qualitative telephone interviews about personal or professional trauma with critical care nurses. The most common method for conducting interviews is face-to-face. However, there is evidence to support telephone interviewing on a variety of sensitive topics including post-traumatic stress disorder (PTSD). Qualitative telephone interviews can limit emotional distress because of the comfort experienced through virtual communication. Critical care nurses are at increased risk of developing PTSD due to the cumulative exposure to work-related stress in the intensive care unit. We explored the methodological and ethical issues of conducting qualitative telephone interviews, drawing on our experiences communicating with a group of critical care nurses. Qualitative research interviews with 27 critical care nurses. Fourteen of the nurses met the diagnostic criteria for PTSD; 13 did not and had scores consistent with high levels of resilience. This is a methodology paper on the authors' experiences of interviewing critical care nurses on sensitive topics via the telephone. The authors found that establishing rapport and connections with the participants and the therapeutic use of non-verbal communication were essential, and fostered trust and compassion. The ethical issues of this mode of communication include protecting the privacy and confidentiality associated with the disclosure of sensitive information, and minimising the risk of psychological harm to the researcher and participants. Qualitative telephone interviews are a valuable method of collecting information on sensitive topics. This paper explores a method of interviewing in the workplace. It will help inform interventions to promote healthy adaptation following trauma exposure in the intensive care unit.

  6. Stability of measures from children's interviews: the effects of time, sample length, and topic.

    Science.gov (United States)

    Heilmann, John; DeBrock, Lindsay; Riley-Tillman, T Chris

    2013-08-01

    The purpose of this study was to examine the reliability of, and sources of variability in, language measures from interviews collected from young school-age children. Two 10-min interviews were collected from 20 at-risk kindergarten children by an examiner using a standardized set of questions. Test-retest reliability coefficients were calculated for 8 language measures. Generalizability theory (G-theory) analyses were completed to document the variability introduced into the measures from the child, session, sample length, and topic. Significant and strong reliability correlation coefficients were observed for most of the language sample measures. The G-theory analyses revealed that most of the variance in the language measures was attributed to the child. Session, sample length, and topic accounted for negligible amounts of variance in most of the language measures. Measures from interviews were reliable across sessions, and the sample length and topic did not have a substantial impact on the reliability of the language measures. Implications regarding the clinical feasibility of language sample analysis for assessment and progress monitoring are discussed.

  7. Topical verapamil as a scar modulator.

    Science.gov (United States)

    Boggio, Ricardo Frota; Boggio, Leonardo Frota; Galvão, Bruno Luiz; Machado-Santelli, Glaucia Maria

    2014-10-01

    Skin injuries and the consequent loss of tissue integrity triggers a sequence of cellular and biochemical events that lead to a healed wound. Any failure during this rather sophisticated process may result in pathological scarring. To evaluate the efficacy of topical verapamil as a modulator of the healing process, a group of five observers (plastic surgeon, dermatologist, physiotherapist, biologist, and layman) analyzed pictures of 120 patients 3 months after abdominoplasty (60 patients) and mammoplasty (60 patients). Half of each group of patients used the topical verapamil scar modulator. Pictures were rated using the Stony Brook Scale. According to the classification established by us, the scars in patients who used topical verapamil scar modulator showed better results than those who did not (p modulators showed 48 and 51.2 % satisfaction for mammoplasty and abdominoplasty scars, respectively. No adverse reactions were observed or reported after the use of topical verapamil. This is the first clinical trial that reports the use of topical verapamil as a modulator in the healing process in the postoperative period. Based on clinical results and on the high level of reliability and statistical significance, we concluded that verapamil at a concentration of 50 µM is an excellent choice as a scar modulator; its use avoids the development of keloids and hypertrophic scars after plastic surgery.

  8. Reconsidering Rapport: Interviewing as Postmodern Inquiry Practice.

    Science.gov (United States)

    Lincoln, Yvonna S.

    Interviewing has been a recognized mainstay of ethnographic fieldwork for more than 100 years. Coupled with participant observation, it was taken to be the complete corpus of anthropological and sociological inquiry activity. Although the repertoire of fieldwork inquirers has grown, interviewing remains a primary data collection technique,…

  9. Interview

    CERN Multimedia

    Association du personnel

    2007-01-01

    New column in ECHO The editorial team would like to give the â€ワpeople at CERN” the chance to have their say. Through regular interviews, it wishes to highlight the particularities of those who help CERN remain a centre of excellence.

  10. Virtual Ethnography: Interactive Interviewing Online as Method

    Directory of Open Access Journals (Sweden)

    Susan Crichton

    2008-03-01

    Full Text Available Recognizing the power of the Internet to connect people, regardless of place or time, we explore the notion of a virtual form of ethnography, suggesting online, textual interactive interviews are worthy of research consideration. This paper reports on three research projects, drawing examples from almost ten years in the evolution of Internet supported conferencing software. It is the position of this paper that we were able to share and develop new insights into being authors, interlocutors, online learners, online researchers, and members of an educational context. Further, we feel that we were able to sustain conversations beyond the scope of many traditional face-to-face interview sessions, noting that the participants enjoyed the process and often found it hard to quit their interactions with us. Hence our position that even though the technology is still emerging and improving, the potential is clearly rich, inviting, and worth continued study.nstructor if given the authority in a social constructivist learning environment.

  11. Dyadic Interviews as a Tool for Qualitative Evaluation

    Science.gov (United States)

    Morgan, David L.; Eliot, Susan; Lowe, Robert A.; Gorman, Paul

    2016-01-01

    Although evaluation researchers frequently make use of focus groups and individual interviews as sources of qualitative data, there has been far less attention to dyadic interviews that create a conversation between two research participants. This article describes dyadic interviews as a format that shares many of the advantages of focus groups,…

  12. Video interviewing as a learning resource

    DEFF Research Database (Denmark)

    Hedemann, Lars; Søndergaard, Helle Alsted

    2011-01-01

    The present investigation was carried out as a pilot study, with the aim of obtaining exploratory insights into the field of learning, and more specifically, how the use of video technology can be used as a mean to excel the outcome of the learning process. The motivation behind the study has its...

  13. Introducing dyadic interviews as a method for collecting qualitative data.

    Science.gov (United States)

    Morgan, David L; Ataie, Jutta; Carder, Paula; Hoffman, Kim

    2013-09-01

    In dyadic interviews, two participants interact in response to open-ended research questions. There are few precedents for using dyadic interviews as a technique for qualitative research. We introduce this method largely in comparison to focus groups, because both represent forms of interactive interviewing. We do not, however, view dyadic interviews as miniature focus groups, and treat them as generating their own opportunities and issues. To illustrate the nature of dyadic interviewing, we present summaries of three studies using this method. In the first study, we used dyadic interviews and photovoice techniques to examine experiences of people with early-stage dementia. In the second study, we explored the experiences of staff who provided services to elderly housing residents. In the third study, we examined barriers and facilitators to substance abuse treatment among Asian Americans and Pacific Islanders in Hawaii. We conclude with a discussion of directions for future research using dyadic interviews.

  14. Honey as a topical treatment for wounds.

    Science.gov (United States)

    Jull, Andrew B; Cullum, Nicky; Dumville, Jo C; Westby, Maggie J; Deshpande, Sohan; Walker, Natalie

    2015-03-06

    Honey is a viscous, supersaturated sugar solution derived from nectar gathered and modified by the honeybee, Apis mellifera. Honey has been used since ancient times as a remedy in wound care. Evidence from animal studies and some trials has suggested that honey may accelerate wound healing. The objective of this review was to assess the effects of honey compared with alternative wound dressings and topical treatments on the of healing of acute (e.g. burns, lacerations) and/or chronic (e.g. venous ulcers) wounds. For this update of the review we searched the Cochrane Wounds Group Specialised Register (searched 15 October 2014); The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2014, Issue 9); Ovid MEDLINE (1946 to October Week 1 2014); Ovid MEDLINE (In-Process & Other Non-Indexed Citations 13 October 2014); Ovid EMBASE (1974 to 13 October 2014); and EBSCO CINAHL (1982 to 15 October 2014). Randomised and quasi-randomised trials that evaluated honey as a treatment for any sort of acute or chronic wound were sought. There was no restriction in terms of source, date of publication or language. Wound healing was the primary endpoint. Data from eligible trials were extracted and summarised by one review author, using a data extraction sheet, and independently verified by a second review author. All data have been subsequently checked by two more authors. We identified 26 eligible trials (total of 3011 participants). Three trials evaluated the effects of honey in minor acute wounds, 11 trials evaluated honey in burns, 10 trials recruited people with different chronic wounds including two in people with venous leg ulcers, two trials in people with diabetic foot ulcers and single trials in infected post-operative wounds, pressure injuries, cutaneous Leishmaniasis and Fournier's gangrene. Two trials recruited a mixed population of people with acute and chronic wounds. The quality of the evidence varied between different comparisons and

  15. Tazarotene as alternative topical treatment for onychomycosis

    Directory of Open Access Journals (Sweden)

    Campione E

    2015-02-01

    Full Text Available Elena Campione,1 Evelin Jasmine Paternò,2 Gaetana Costanza,2,3 Laura Diluvio,1 Isabella Carboni,1 Daniele Marino,4 Cartesio Favalli,4 Sergio Chimenti,1 Luca Bianchi,1 Augusto Orlandi2,3 1Department of Dermatology, 2Department of Biomedicine and Prevention, 3Department of Anatomic Pathology, Policlinic Tor Vergata, 4Department of Microbiology, University of Rome Tor Vergata, Rome, Italy Background: Distal and lateral onychomycoses are the most frequent forms of onychomycosis, causing subungual hyperkeratosis that usually limits local penetration of antimycotic drugs. Tazarotene exerts anti-inflammatory and immune-modulating activities toward both infective agents and damaged keratinocytes. Given the well-documented efficacy of tazarotene on hyperkeratotic nail psoriasis, we investigated its therapeutic use in onychomycosis. Patients and methods: We designed a preliminary open clinical trial in patients affected by distal and lateral subungual onychomycosis of the toenails and verified the fungistatic activity of tazarotene in vitro. Fifteen patients were treated with topical tazarotene 0.1% gel once per day for 12 weeks. Mycological cultures and potassium hydroxide stains of nail samples were performed at the beginning and at the end of the study. Treatment was considered effective when clinical healing and negative mycological culture were obtained. Onycholysis, nail bed discoloration, and subungual hyperkeratosis were measured using standardized methodologies and analyzed by means of Mann–Whitney test and analysis of variance. Fungistatic activity of tazarotene was evaluated by disk diffusion assay. Results: Six patients (40% reached a mycological cure on target nail samples already after 4 weeks of treatment. Complete clinical healing and negative cultures were reached in all patients at week 12, with a significant improvement of all clinical parameters of the infected nails. Disk diffusion assay after 48 hours of incubation with

  16. Interviewing Objects: Including Educational Technologies as Qualitative Research Participants

    Science.gov (United States)

    Adams, Catherine A.; Thompson, Terrie Lynn

    2011-01-01

    This article argues the importance of including significant technologies-in-use as key qualitative research participants when studying today's digitally enhanced learning environments. We gather a set of eight heuristics to assist qualitative researchers in "interviewing" technologies-in-use (or other relevant objects), drawing on concrete…

  17. Soaps and Germicides as Adjunct Topical Antimycotic Agents on ...

    African Journals Online (AJOL)

    Objective: The study aims at evaluating the potentials of soaps and germicides / disinfectants as adjunct topical anti-vulvovaginal candidasis agents. Methods: In vitro inhibitory activities of the test agents, prepared according to the manufacturer's specification for toilet and midwifery purposes were determined using modified ...

  18. The impact of self-interviews on response patterns for sensitive topics: a randomized trial of electronic delivery methods for a sexual behaviour questionnaire in rural South Africa.

    Science.gov (United States)

    Harling, Guy; Gumede, Dumile; Mutevedzi, Tinofa; McGrath, Nuala; Seeley, Janet; Pillay, Deenan; Bärnighausen, Till W; Herbst, Abraham J

    2017-08-17

    Self-interviews, where the respondent rather than the interviewer enters answers to questions, have been proposed as a way to reduce social desirability bias associated with interviewer-led interviews. Computer-assisted self-interviews (CASI) are commonly proposed since the computer programme can guide respondents; however they require both language and computer literacy. We evaluated the feasibility and acceptability of using electronic methods to administer quantitative sexual behaviour questionnaires in the Somkhele demographic surveillance area (DSA) in rural KwaZulu-Natal, South Africa. We conducted a four-arm randomized trial of paper-and-pen-interview, computer-assisted personal-interview (CAPI), CASI and audio-CASI with an age-sex-urbanicity stratified sample of 504 adults resident in the DSA in 2015. We compared respondents' answers to their responses to the same questions in previous surveillance rounds. We also conducted 48 cognitive interviews, dual-coding responses using the Framework approach. Three hundred forty (67%) individuals were interviewed and covariates and participation rates were balanced across arms. CASI and audio-CASI were significantly slower than interviewer-led interviews. Item non-response rates were higher in self-interview arms. In single-paper meta-analysis, self-interviewed individuals reported more socially undesirable sexual behaviours. Cognitive interviews found high acceptance of both self-interviews and the use of electronic methods, with some concerns that self-interview methods required more participant effort and literacy. Electronic data collection methods, including self-interview methods, proved feasible and acceptable for completing quantitative sexual behaviour questionnaires in a poor, rural South African setting. However, each method had both benefits and costs, and the choice of method should be based on context-specific criteria.

  19. The impact of self-interviews on response patterns for sensitive topics: a randomized trial of electronic delivery methods for a sexual behaviour questionnaire in rural South Africa

    Directory of Open Access Journals (Sweden)

    Guy Harling

    2017-08-01

    Full Text Available Abstract Background Self-interviews, where the respondent rather than the interviewer enters answers to questions, have been proposed as a way to reduce social desirability bias associated with interviewer-led interviews. Computer-assisted self-interviews (CASI are commonly proposed since the computer programme can guide respondents; however they require both language and computer literacy. We evaluated the feasibility and acceptability of using electronic methods to administer quantitative sexual behaviour questionnaires in the Somkhele demographic surveillance area (DSA in rural KwaZulu-Natal, South Africa. Methods We conducted a four-arm randomized trial of paper-and-pen-interview, computer-assisted personal-interview (CAPI, CASI and audio-CASI with an age-sex-urbanicity stratified sample of 504 adults resident in the DSA in 2015. We compared respondents’ answers to their responses to the same questions in previous surveillance rounds. We also conducted 48 cognitive interviews, dual-coding responses using the Framework approach. Results Three hundred forty (67% individuals were interviewed and covariates and participation rates were balanced across arms. CASI and audio-CASI were significantly slower than interviewer-led interviews. Item non-response rates were higher in self-interview arms. In single-paper meta-analysis, self-interviewed individuals reported more socially undesirable sexual behaviours. Cognitive interviews found high acceptance of both self-interviews and the use of electronic methods, with some concerns that self-interview methods required more participant effort and literacy. Conclusions Electronic data collection methods, including self-interview methods, proved feasible and acceptable for completing quantitative sexual behaviour questionnaires in a poor, rural South African setting. However, each method had both benefits and costs, and the choice of method should be based on context-specific criteria.

  20. [Science as a profession: an interview with Carlos Chagas Filho].

    Science.gov (United States)

    Chagas Filho, Carlos

    2012-06-01

    The editing of this interview focuses on aspects of the extensive professional career of Carlos Chagas Filho, who was the founder of the Instituto de Biofísica of the Universidade do Brasil, currently the Universidade Federal do Rio de Janeiro. It highlights the scientific and political role he played in Brazilian science and on the international scene. His memoirs include his experience at the Instituto Oswaldo Cruz, where he began his scientific training; the efforts to create the Laboratório de Física Biológica, succeeded by the Instituto de Biofísica; his work on the Conselho Nacional de Pesquisas and the Academia Brasileira de Ciências; the part he played at the United Nations Educational, Scientific and Cultural Organization; his time as president of the Pontifical Academy of Sciences of the Vatican, which led him to ponder questions about the relationship between science and religion.

  1. The Reference Interview as a Creative Art. Second Edition.

    Science.gov (United States)

    Jennerich, Elaine Z.; Jennerich, Edward J.

    Customer service is a vital part of library service. The reference interview remains a key element in assisting library patrons with information needs. This book shows librarians how to combine creativity with professional expertise in reference interviews, to provide quality customer service and satisfy patrons. The book is divided into 11…

  2. [The interview as a research data collection method].

    Science.gov (United States)

    Debout, Christophe

    2016-04-01

    The interview is a widely-used method for collecting research data, notably in qualitative and mixed protocols. However, it is an umbrella term which groups together numerous types of interviews adapted to the methodological diversity which characterises nursing science. Copyright © 2016. Published by Elsevier Masson SAS.

  3. Being Irrationally Funny as a Cognitive Psychologist: Interview With Dan Ariely.

    Science.gov (United States)

    Ariely, Dan; Popescu, Beatrice

    2015-11-01

    The idea of interviewing Dan Ariely was somehow latent on my mind since I started being interested in cognitive psychology and cognitive behavior psychotherapy, but actually got more ardent ever since irrationality became a research topic for his team at Duke University. I picked him as an interviewee thinking not only at his exceptional skills as a researcher and as Kahnemann 'disciple', but mainly for his fantastic wit, true modesty and utmost interest in making people's lives easier and more comfortable, by creating awareness on a lot of topics otherwise neglected. Dan Ariely's very agreeable personality and humor would not let you think of him as a burnt casualty who, in his youth struggled to survive a personal drama, so well-documented in his paper "Painful lessons" posted on the MIT website (http://web.mit.edu/ariely/www/MIT/Papers/mypain.pdf). I think reading his paper and also this transcribed interview with him would be also comforting for people who found out about Bucharest fire incident that rocked our society and also for people who are personally related to this tragedy.

  4. Interviewing separately or as couples? Considerations of authenticity of method.

    Science.gov (United States)

    Taylor, Bridget; de Vocht, Hilde

    2011-11-01

    Heideggerian researchers recognize that people and their worlds are coconstructed; people make sense of their world from within it, not detached from it. The presence of one's partner in a joint interview will therefore influence the experience of participants, and will also influence the descriptions they provide. In this article, we present a reflexive discussion of two studies in which we used Heideggerian hermeneutic phenomenology to explore people's experiences of sexuality and intimacy within the context of their illness. We present the Heideggerian concepts of Dasein, authenticity and truth, and draw on extracts from our interview transcripts to exemplify the different effects of joint and one-to-one interviews. We also discuss ethical considerations regarding these different interview approaches. Heidegger's philosophy does not preferentially support either method, but helps us to be clearer about the merits and limitations of each approach. Combining both approaches provides richer understanding of phenomena.

  5. Interview with Ron Wasserstein

    Science.gov (United States)

    Rossmann, Allan; Wasserstein, Ron

    2014-01-01

    Ron Wasserstein is Executive Director of the American Statistical Association (ASA). He previously served as Vice-President for Academic Affairs and Professor of Statistics at Washburn University. This interview took place via email on January 21- February 24, 2014. Topics covered in this interview are as follows: 1) Beginnings, 2) Teaching…

  6. Topical fluoride as a cause of dental fluorosis in children.

    Science.gov (United States)

    Wong, May Cm; Glenny, Anne-Marie; Tsang, Boyd Wk; Lo, Edward Cm; Worthington, Helen V; Marinho, Valeria Cc

    2010-01-20

    associations were found between starting using fluoride toothpaste/toothbrushing before or after the age of 24 months and fluorosis (data from observational studies). From the RCTs, use of higher level of fluoride was associated with an increased risk of fluorosis. No significant association between the frequency of toothbrushing or the amount of fluoride toothpaste used and fluorosis was found. There should be a balanced consideration between the benefits of topical fluorides in caries prevention and the risk of the development of fluorosis. Most of the available evidence focuses on mild fluorosis. There is weak unreliable evidence that starting the use of fluoride toothpaste in children under 12 months of age may be associated with an increased risk of fluorosis. The evidence for its use between the age of 12 and 24 months is equivocal. If the risk of fluorosis is of concern, the fluoride level of toothpaste for young children (under 6 years of age) is recommended to be lower than 1000 parts per million (ppm).More evidence with low risk of bias is needed. Future trials assessing the effectiveness of different types of topical fluorides (including toothpastes, gels, varnishes and mouthrinses) or different concentrations or both should ensure that they include an adequate follow-up period in order to collect data on potential fluorosis. As it is unethical to propose RCTs to assess fluorosis itself, it is acknowledged that further observational studies will be undertaken in this area. However, attention needs to be given to the choice of study design, bearing in mind that prospective, controlled studies will be less susceptible to bias than retrospective and/or uncontrolled studies.

  7. Topical steroid abuse: its use as a depigmenting agent.

    Science.gov (United States)

    Nnoruka, Edith; Okoye, Obiefuna

    2006-06-01

    This study was undertaken to document prevalence, motives and observed complications of steroid use as a depigmenting agent amongst African blacks in southeast Nigeria. This practice is very common in the African environment. Consecutive new patients attending the dermatology clinic of the University of Nigeria TeachingHospital, Enugu, from June to December 2004 were recruited. Active substances of products used were determined from packages, while unknown concoctions were analyzed. Chi-squared and Fischer tests were used for statistical analysis, with a significant threshold fixed at 5%. Females aged 18-69 years accounted for 75% (414) of patients. Main topical steroids used by both women and men were class-1 steroids, and these were often compounded with other bleaching products. Median duration of usage was 9 years +/- 1.3. Disorders observed included steroid-induced acne (45.3%), macular hyperpigmentation of face (37.2%), mycoses (40.4%), striae (28.3%), telangiectasis (21.3%), hypertrichosis (13.9%) and diabetes mellitus (2.1%). Duration of utilization of these topical steroids was significantly associated with severe local and systemic consequences, while withdrawal of the offending steroids usually resulted in severe withdrawal dermatitis that was unpleasant to patients. This may suggest that discontinuation is impossible.

  8. Topical corticosteroids as adjunctive therapy for bacterial keratitis

    Science.gov (United States)

    Herretes, Samantha; Wang, Xue; Reyes, Johann MG

    2014-01-01

    Background Bacterial keratitis is a serious ocular infectious disease that can lead to severe visual disability. Risk factors for bacterial corneal infection include contact lens wear, ocular surface disease, corneal trauma, and previous ocular or eyelid surgery. Topical antibiotics constitute the mainstay of treatment in cases of bacterial keratitis, whereas the use of topical corticosteroids as an adjunctive therapy to antibiotics remains controversial. Topical corticosteroids are usually used to control inflammation using the smallest amount of the drug. Their use requires optimal timing, concomitant antibiotics, and careful follow-up. Objectives The objective of the review was to assess the effectiveness and safety of corticosteroids as adjunctive therapy for bacterial keratitis. Secondary objectives included evaluation of health economic outcomes and quality of life outcomes. Search methods We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) (2014, Issue 6), Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid OLDMEDLINE (January 1946 to July 2014), EMBASE (January 1980 to July 2014), Latin American and Caribbean Health Sciences Literature Database (LILACS) (January 1982 to July 2014), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com), ClinicalTrials.gov (www.clinicaltrials.gov) and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en). We did not use any date or language restrictions in the electronic searches for trials. We last searched the electronic databases on 14 July 2014. We also searched the Science Citation Index to identify additional studies that had cited the only trial included in the original version of this review, reference lists of included trials, earlier reviews, and the American Academy of Ophthalmology guidelines. We also contacted experts to identify any unpublished and

  9. The Interview as Collaborative Achievement: Interaction, Identity, and Ideology in a Speech Event

    Science.gov (United States)

    Talmy, Steven

    2011-01-01

    This article contrasts a common conceptualization of the interview in applied linguistics, referred to as an "interview as research instrument" perspective, with an alternative, referred to as a "research interview as social practice" orientation. It illustrates implications of the two perspectives on interviews by contrasting…

  10. The CEO as organizational architect: an interview with Xerox's Paul Allaire. Interview by Robert Howard.

    Science.gov (United States)

    Allaire, P

    1992-01-01

    As chairman and CEO of the Xerox Corporation, Paul Allaire leads a company that is a microcosm of the changes transforming American business. With the introduction of the first plain-paper copier in 1959, Xerox invented a new industry and launched itself on a decade of spectacular growth. But easy growth led Xerox to neglect the fundamentals of its core business, leaving the company vulnerable to low-cost Japanese competition. Starting in the mid-1980s, Xerox embarked on a long-term effort to regain its dominant position in world copier markets and to create a new platform for future growth. Thanks to the company's Leadership through Quality program, Xerox became the first major U.S. company to win back market share from the Japanese. Allaire describes his efforts to take Xerox's corporate transformation to a new level. Since becoming CEO in 1990, he has repositioned Xerox as "the document company" at the intersection of the worlds of paper-based and electronic information. And he has guided the company through a fundamental redesign of what he calls the "organizational architecture" of Xerox's document processing business. Few CEOs have approached the process of organizational redesign as systematically and methodically as Allaire has. He has created a new corporate structure that balances independent business divisions with integrated R&D and customer operations organizations. He has redefined managerial roles and responsibilities, changed the way managers are selected and compensated, and renewed the company's senior management ranks. And he has articulated the new values and behaviors Xerox managers will need to thrive in a more competitive and fast-changing business environment.

  11. Language as a Strategy for Learning Science Curriculum Topics

    Directory of Open Access Journals (Sweden)

    Boris Fernando Candela Rodríguez

    2017-01-01

    Full Text Available Since the 1990s, teacher educators have shown an increasing interest in introducing the skills of orality, reading and writing in science classrooms as a learning tool. To do so, they rely on literature from research, which initially shows how weakly those skills have been implemented in school. Thus, the present study aims to synthesize the main aspects that provides literature on the introduction of language explicitly in the science classroom. In that sense, a research methodology content analysis is used, which allowed to “see” that  skills of orality, reading and writing are powerful thinking and learning of science strategies, considering that these allow students, at first, become aware about their alternative conceptions on a specific topic, and then make these conceptions evolve progressively towards the theoretical models of science.

  12. [Topical voriconazole as an effective treatment for fungal keratitis].

    Science.gov (United States)

    Wang, L Y; Xu, Z Z; Zhang, J J; Sun, S T; Li, J; Yu, X F; Zhu, L; Zhang, Y Q; He, Y; Li, J C; Wang, L L; Tao, S Y

    2016-09-11

    To evaluate the efficacy of topical voriconazole in patients with fungal keratitis caused by different fungal species. Interventional case series. Eighty-four patients aged 18 years or older from central China with confirmed fungal keratitis who presented at the outpatient department of Henan Eye Institute were enrolled in the study. The patients underwent in vivo confocal scanning laser microscopy examination, coneal scraping and microscopic examination and fungal culture, and then received topical voriconazole, closed curative effects were conducted. The sensitivity of three different diagnostic techniques, spectrum of the fungi, cure rate for fungal corneal infection related to each species were analyzed. In our study, 84 patients were diagnosed with fungal keratitis based on clinical symptoms, and results of at least one of the examinations of in vivo confocal scanning laser microscopy, conventional smear, and corneal scraping culture and the sensitivity were 92.85%(78/84), 85.71%(72/84), 84.52%(71/84)respectively. In viro confocal scanning laser microscopy. Successful management was achieved in 83.33% of the patients. Topical voriconazole treatment failed in 14 patients(16.67%), who required surgical treatment. In 36 patients with Fusarium corneal infections, 26(72.22%)were successfully treated with topical voriconazole; however, in 18 patients with Aspergillus corneal infections and 7 patients with Alternaria corneal infections, 94.44% and 100.00% of them were successfully treated, respectively. In a case-based dynamic tracking study, in vivo confocal microscopy provided real-time dynamic detection of surviving hyphae. The existence of hyphae was(38.35±17.32)days for Fusarium,(25.00±16.11)days for Aspergillus,(21.00±4.36)days for Alternaria, and(41.50±31.68)days for the focus in the deep stroma. The duration of treatment was similar for all four groups. Topical application of voriconazole is on effective method for the freatment of fungal keratitis

  13. The interpreter as co-interviewer: the role of the interpreter during interviews in cross-language health research.

    Science.gov (United States)

    Suurmond, Jeanine; Woudstra, Anke; Essink-Bot, Marie-Louise

    2016-07-01

    Interviews with ethnic minority patients provide a rich source of data to understand their perspectives of disease and its management. Language barriers are, however, often a problem so interpreters need to be used. We explored the impact of the interpreter on cross-language interviews between researchers and respondents. Secondary analysis of four interviews between researchers and patients involving professional interpreters. Interpreters were actively involved and influenced the interview in several ways: they assumed the interviewer's communicative role, edited information; initiated information-seeking, took over control of the interview, and took over the respondent's role. While the interpreter supported the interviewer, they posed risks to the quality of the interview. Researchers need to be aware of the influence of interpreters. Researchers should instruct interpreters carefully about their roles though they may benefit from interpreters' strategies to support them. © The Author(s) 2016.

  14. Topical ranibizumab as a treatment of corneal neovascularization.

    Science.gov (United States)

    Ferrari, Giulio; Dastjerdi, Mohammad H; Okanobo, Andre; Cheng, Sheng-Fu; Amparo, Francisco; Nallasamy, Nambi; Dana, Reza

    2013-07-01

    To examine the effect of topical ranibizumab on clinically stable corneal neovascularization (NV). This was a prospective, open-label, monocentric, uncontrolled noncomparative study. Ten eyes of 9 patients with corneal NV received topical ranibizumab (1%) 4 times a day for 3 weeks with a follow-up period of 16 weeks. The main corneal NV outcome measures were: neovascular area, the area occupied by the corneal neovessels; vessel caliber (VC), the mean diameter of the corneal neovessels; and invasion area (IA), the fraction of the total cornea area covered by the vessels. This study was conducted at the Massachusetts Eye and Ear Infirmary, Boston, MA. Statistically significant decreases in neovascular area (55.3%, P < 0.001), which lasted through 16 weeks, and VC (59%, P < 0.001), which continued to improve up to week 16, were observed after treatment. No significant decrease was observed in IA (12.3%, P = 0.49). There was no statistically significant change in visual acuity or intraocular pressure. No adverse events ascribed to the treatment were noted. Topical application of ranibizumab is effective in reducing the severity of corneal NV in the context of established corneal NV, mostly through decrease in VC rather than IA.

  15. Topical Ranibizumab as a Treatment of Corneal Neovascularization

    Science.gov (United States)

    Ferrari, Giulio; Dastjerdi, Mohammad H.; Okanobo, Andre; Cheng, Sheng-Fu; Amparo, Francisco; Nallasamy, Nambi; Dana, Reza

    2014-01-01

    Purpose To examine the effect of topical ranibizumab on clinically stable corneal neovascularization (NV). Methods This was a prospective, open-label, monocentric, uncontrolled, non-comparative study. Ten eyes of 9 patients with corneal NV received topical ranibizumab (1%) 4 times a day for 3 weeks with a follow-up of 16 weeks. The main corneal neovascularization outcome measures were: neovascular area (NA), the area occupied by the corneal neovessels; vessel caliber (VC), the mean diameter of the corneal neovessels; and invasion area (IA), the fraction of the total cornea area covered by the vessels. This study was conducted at the Massachusetts Eye and Ear Infirmary, Boston, MA, USA. Results Statistically significant decreases in NA (55.3%, P<0.001), which lasted through 16 weeks, and VC (59%, P<0.001), which continued to improve up to week 16, were observed after treatment. No significant decrease was observed in IA (12.3%, P=0.49). There was no statistically significant change in visual acuity or intraocular pressure. No adverse events ascribed to the treatment were noted. Conclusions Topical application of ranibizumab is effective in reducing the severity of corneal NV in the context of established corneal NV, mostly through decrease in VC rather than IA. PMID:23407316

  16. Preclinical evaluation of lime juice as a topical microbicide candidate

    Directory of Open Access Journals (Sweden)

    Boothe Adrienne R

    2008-01-01

    Full Text Available Abstract Background The continued growth of the global HIV epidemic highlights the urgent need to develop novel prevention strategies to reduce HIV transmission. The development of topical microbicides is likely to take a number of years before such a product would be widely available. This has resulted in a call for the rapid introduction of simpler vaginal intervention strategies in the interim period. One suggested practice would be vaginal douching with natural products including lime or lemon juice. Here we present a comprehensive preclinical evaluation of lime juice (LiJ as a potential intervention strategy against HIV. Results Pre-treatment of HIV with LiJ demonstrated direct virucidal activity, with 10% juice inactivating the virus within 5 minutes. However, this activity was significantly reduced in the presence of seminal plasma, where inactivation required maintaining a 1:1 mixture of neat LiJ and seminal plasma for more than 5 minutes. Additionally, LiJ demonstrated both time and dose-dependent toxicity towards cervicovaginal epithelium, where exposure to 50% juice caused 75–90% toxicity within 5 minutes increasing to 95% by 30 minutes. Cervicovaginal epithelial cell monolayers were more susceptible to the effects of LiJ with 8.8% juice causing 50% toxicity after 5 minutes. Reconstructed stratified cervicovaginal epithelium appeared more resilient to LiJ toxicity with 30 minutes exposure to 50% LiJ having little effect on viability. However viability was reduced by 75% and 90% following 60 and 120 minutes exposure. Furthermore, repeat application (several times daily of 25% LiJ caused 80–90% reduction in viability. Conclusion These data demonstrate that the virucidal activity of LiJ is severely compromised in the presence of seminal plasma. Potentially, to be effective against HIV in vivo, women would need to apply a volume of neat LiJ equal to that of an ejaculate, and maintain this ratio vaginally for 5–30 minutes after

  17. People with ID as interviewers and co-researchers: experiences and reflection.

    NARCIS (Netherlands)

    Lieshout, H. van

    2012-01-01

    Aim: To share the experience of working with people with intellectual disabilities (ID) as interviewers in a qualitative study about community participation of people with ID. We reflect on two perspectives: the interviewers and the researchers. Method: Eighteen people with ID were interviewed by

  18. Poetry Education Research as an Anchorage of Thought: Using Poetry as Interview Stimulus Material

    Science.gov (United States)

    Xerri, Daniel

    2017-01-01

    Interviews in qualitative research may sometimes employ stimulus material as a means of eliciting richer data. However, scant consideration has been given to the use of poetry for this purpose, especially within the field of poetry education research. This article seeks to address the gap in the literature by illustrating how the use of poetry as…

  19. Transcultural Experience and Multiple Biographies as a Research Topic

    Directory of Open Access Journals (Sweden)

    Maciej Falski

    2014-12-01

    Full Text Available Transcultural Experience and Multiple Biographies as a Research Topic Transculturality refers to the traditional understanding of culture as self-contained, concentrated around its own center and producing clear borders. “Trans” signifies the act of crossing; it signifies overcoming such borders. It looks at phenomena, people, and notions that are not limited to one communicational environment, but are represented in multiple locations, or contexts. Or rather—they cannot be fully ascribed to one “culture,” because they exhibit, traits of both (or more cultures. Culture studies often describe, also, people with “trans” life stories; it is not a matter of simple crossing of borders, living a bit in one environment and a bit in another. The point is that their sense of belonging is of a mixed, ambiguous character, and their identity is blurred. It is a question of practices that they draw from two or more sources, creating a peculiar amalgam characteristic of living “in between.” Transculturality, just like multiple biographies, means both partial belonging and dual belonging, which is very well illustrated by the case studies presented in the volume: they have in a way, varied roots, which means they bear unique, hybrid fruit.   Doświadczenie transkulturowe i biografie wielorakie jako temat badawczy Transkulturowość odnosi się do tradycyjnego pojmowania kultury jako samowystarczalnej, skoncentrowanej na sobie i wytwarzającej wyraźne granice. Przyrostek „trans” oznacza akt przekraczania tak wytyczonych granic. Kategoria transkulturowości skłania do patrzenia na zjawiska, biografie i pojęcia jako coś, co nie ogranicza się do jednego środowiska komunikacyjnego, lecz występuje bądź przejawia się w wielu miejscach i kontekstach. Można też powiedzieć, że nie można ich przypisać do jednej „kultury”, ponieważ reprezentują cechy dwóch (lub więcej wspólnot kulturowych. Studia kulturowe często zajmuj

  20. Individual Interviews as Insight into Children's Computational Thinking

    Science.gov (United States)

    Higgins, Heidi J.; Wiest, Lynda R.

    2006-01-01

    Teachers who believe "practice makes perfect" may engage students in repetitive, perhaps timed, computational exercises. If educators teach students to understand the procedures they practice, however, they will not need as much drill and they will have more flexible use of the computations they perform. Three-quarters of a century ago, William…

  1. Osmolarity as a contributing factor in topical drug delivery

    Science.gov (United States)

    Funke, Claire; Szeri, Andrew J.

    2017-11-01

    Gels and dissolvable solids are drug delivery platforms being evaluated for application of active pharmaceutical ingredients, termed microbicides, which act topically against infection by sexually transmitted HIV. In previous work, we have investigated how dilution by naturally produced fluid from the vaginal mucosa affects drug transport into the vaginal wall. We expand on this work by no longer assuming a constant flux and instead developing a relation for fluid transport based on osmolarity - thus allowing fluid to pass both into and out of epithelial cells. This relation shows that varying the osmolarity of the applied solution can have a significant effect on the amount of drug delivered to its target while holding the applied amount constant. This effect is modulated by a dimensionless group that relates the rates of solute and solvent transport. Ultimately, our goal is to develop a tool to understand better how to manipulate solution osmolarity in order to improve drug delivery within safety parameters for mucosal tissue.

  2. The interpreter as co-interviewer: the role of the interpreter during interviews in cross-language health research

    NARCIS (Netherlands)

    Suurmond, Jeanine; Woudstra, Anke; Essink-Bot, Marie-Louise

    2016-01-01

    Interviews with ethnic minority patients provide a rich source of data to understand their perspectives of disease and its management. Language barriers are, however, often a problem so interpreters need to be used. We explored the impact of the interpreter on cross-language interviews between

  3. Hermeneutic interviewing: an example of its development and use as research method.

    Science.gov (United States)

    Geanellos, R

    1999-06-01

    In a study exploring the practice knowledge of nursing on adolescent mental health units, I chose hermeneutic philosophy to guide the conduct of the research. Immediately, I encountered the problem that hermeneutics is essentially unconcerned with its use as research method. The need for congruence between the study's hermeneutic foundations and the methodological processes of the research, led me to develop a style of hermeneutic interviewing for the purpose of information gathering. I did this using Gadamer's (1979) fundamental principles of: (1) tradition, (2) dialectics of interpretation, and (3) dialectic of question and answer. These principles are examined and discussed. The actualization of hermeneutic interviewing, as a means of information gathering, proved challenging. Using interview excerpts, I demonstrate my use of hermeneutic interviewing as research method, and critique my interviewing skills in relation to the fundamental principles from which this style of interviewing was developed.

  4. Testing Skype as an interview method in epidemiologic research: response and feasibility.

    Science.gov (United States)

    Weinmann, Tobias; Thomas, Silke; Brilmayer, Susanne; Heinrich, Sabine; Radon, Katja

    2012-12-01

    Despite its popularity, Skype has not been tested as a tool for epidemiologic research. We examined its feasibility in Germany. A population-based sample of young adults was randomly invited to a Skype (n = 150) or a phone interview (n = 150). Response and duration of interviews were analysed to evaluate the feasibility of Skype interviews. Response was low and, with 10 % (95 % CI 5-15 %), even worse among Skype candidates, compared to 22 % (15-28 %) in the phone group. A third of the Skype group asked for being interviewed by phone. Median duration was 34.0 minutes for Skype interviews and 37.0 minutes for phone interviews. Skype is not yet a feasible tool for data collection in Germany.

  5. An interview with the president. "I'd like to see America used as a global lab".

    Science.gov (United States)

    Clinton, W J

    2000-12-22

    AN INTERVIEW WITH THE PRESIDENT:"I'd Like to See America Used as a Global Lab" President Bill Clinton met with Science magazine on 6 December for a broad-ranging interview that looked at how science and technology are likely to change our world, and how he might continue to interact with the scientific community after he leaves office in January. What emerged confirms a portrait many people have painted of Clinton: a polymath who rarely resorts to the platitudes we have come to expect from politicians--especially on the topic of science. This online transcript of the conversation between Clinton and Science Editor Ellis Rubinstein contains material which could not be included in print for space reasons.

  6. The artist interview as a conservation tool for process-based art by Sjoerd Buisman

    NARCIS (Netherlands)

    Stigter, S.; Beerkens, L.; 't Hoen, P.; Hummelen, IJ.; van Saaze, V.; Scholte, T.; Stigter, S.

    2012-01-01

    The oeuvre interview conducted with Sjoerd Buisman in 1998 was followed up ten years later with a case interview about the ‘planting piece’ Dennenwal from the collection of the Kröller-Müller Museum. Living material such as trees, grasses and potatoes, which frequently recurs in the work of

  7. The Research Interview as Discourses Crossing Swords: The Researcher and Apprentice on Crossing Roads

    Science.gov (United States)

    Tanggaard, Lene

    2007-01-01

    This article presents a conception of the qualitative research interview as discourses crossing swords. The article draws on examples showing how the researchers' view on learning is challenged by the interviewed apprentices. The apprentices do not assume learning in itself to be an important aspect of their lives. They consider the process of…

  8. The University as an Institution Today: Topics for Reflection | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The second half of this century has witnessed a global boom in higher education. Today, in both the developing and industrialized worlds, the vital role of higher education in society is accepted. However, as the end of the second millennium draws near, we must reflect upon the university as an institution; we must look at its ...

  9. The University as an Institution Today: Topics for Reflection | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The University as an Institution Today interweaves the themes of history, theory, and administration in probing the fundamentals of the university ideal. ... A Colombian philosopher, theologian, architectural historian, and educator, Father Alphonso Borrero Cabal, S.J., is an internationally recognized expert in the field of ...

  10. Recreational football as a health promoting activity: a topical review

    DEFF Research Database (Denmark)

    Krustrup, Peter; Aagaard, Per; Nybo, Lars

    2010-01-01

    -intensity continuous running and strength training. Further, recreational football training enhances fat oxidation during exercise and results in a higher fat loss than interval training and strength training, and results in marked muscle hypertrophy and elevates bone mass, more than interval and continuous running......The present review addresses the physiological demands during recreational football training and the effects on central health variables that influence the risk of life-style diseases of young and middle-aged men. Recent studies have established that recreational football, carried out as small......-sided games can be characterized as having a high aerobic component with mean heart rates of 80-85% of maximum heart rate, which is similar to values observed for elite football players. In addition, the training includes multiple high-speed runs, sprints, turns, jumps and tackles, which provide a high impact...

  11. Solid effervescent formulations as new approach for topical minoxidil delivery.

    Science.gov (United States)

    Pereira, Maíra N; Schulte, Heidi L; Duarte, Natane; Lima, Eliana M; Sá-Barreto, Livia L; Gratieri, Tais; Gelfuso, Guilherme M; Cunha-Filho, Marcilio S S

    2017-01-01

    Currently marketed minoxidil formulations present inconveniences that range from a grease hard aspect they leave on the hair to more serious adverse reactions as scalp dryness and irritation. In this paper we propose a novel approach for minoxidil sulphate (MXS) delivery based on a solid effervescent formulation. The aim was to investigate whether the particle mechanical movement triggered by effervescence would lead to higher follicle accumulation. Preformulation studies using thermal, spectroscopic and morphological analysis demonstrated the compatibility between effervescent salts and the drug. The effervescent formulation demonstrated a 2.7-fold increase on MXS accumulation into hair follicles casts compared to the MXS solution (22.0±9.7μg/cm 2 versus 8.3±4.0μg/cm 2 ) and a significant drug increase (around 4-fold) in remaining skin (97.1±29.2μg/cm 2 ) compared to the drug solution (23.5±6.1μg/cm 2 ). The effervescent formulations demonstrated a prominent increase of drug permeation highly dependent on the effervescent mixture concentration in the formulation, confirming the hypothesis of effervescent reaction favoring drug penetration. Clinically, therapy effectiveness could be improved, increasing the administration interval, hence, patient compliance. More studies to investigate the follicular targeting potential and safety of new formulations are needed. Copyright © 2016 Elsevier B.V. All rights reserved.

  12. The Dental School Interview As a Predictor of Dental Students' OSCE Performance.

    Science.gov (United States)

    Park, Sang E; Price, Mirissa D; Karimbux, Nadeem Y

    2018-03-01

    The aim of this study was to evaluate the use of the dental school admissions interview score as a noncognitive indicator of performance in predoctoral dental education, with specific attention to whether a correlation existed between the admissions interview scores and performance on the objective structured clinical examination (OSCE). The study population consisted of all 175 students in the Harvard School of Dental Medicine (HSDM) DMD Classes of 2012 through 2016. Data on students' gender and age on entering dental school were self-reported using their applications for admission to the HSDM DMD program. Data on students' OSCE scores for three examination sessions were collected from the Office of Dental Education. The results showed that the students' interview scores did not significantly correlate with OSCE performance on any of the three exams. Performance on the first and second OSCEs did, however, correlate with performance on the third OSCE (pOSCEs; however, among male students, there was a significant negative correlation (pOSCEs. There was no significant association between gender and OSCE or interview score. These results suggest that although the admissions interview scores can serve as an important resource in student selection, with the lack of association between interview and OSCE scores, it is possible that the communication skills required for the interview do not directly overlap with those required for OSCE success.

  13. The role of topical antibiotics used as prophylaxis in surgical site infection prevention.

    LENUS (Irish Health Repository)

    McHugh, S M

    2011-04-01

    Compared with systemic antibiotic therapy, the topical or local delivery of an antibiotic has many potential advantages. However, local antibiotics at the surgical site have received very limited approval in any of the surgical prophylaxis consensus guidelines that we are aware of. A review of the literature was carried out through searches of peer-reviewed publications in PubMed in the English language over a 30 year period between January 1980 and May 2010. Both retrospective and prospective studies were included, as well as meta-analyses. With regard to defining \\'topical\\' or \\'local\\' antibiotic application, the application of an antibiotic solution to the surgical site intraoperatively or immediately post-operatively was included. A number of surgical procedures have been shown to significantly benefit from perioperative topical prophylaxis, e.g. joint arthroplasty, cataract surgery and, possibly, breast augmentation. In obese patients undergoing abdominal surgery, topical surgical prophylaxis is also proven to be beneficial. The selective use of topical antibiotics as surgical prophylaxis is justified for specific procedures, such as joint arthroplasty, cataract surgery and, possibly, breast augmentation. In selective cases, such as obese patients undergoing abdominal surgery, topical surgical prophylaxis is also proven to be beneficial. Apart from these specific indications, the evidence for use of topical antibiotics in surgery is lacking in conclusive randomized controlled trials.

  14. The role of topical antibiotics used as prophylaxis in surgical site infection prevention.

    LENUS (Irish Health Repository)

    McHugh, S M

    2012-02-01

    Compared with systemic antibiotic therapy, the topical or local delivery of an antibiotic has many potential advantages. However, local antibiotics at the surgical site have received very limited approval in any of the surgical prophylaxis consensus guidelines that we are aware of. A review of the literature was carried out through searches of peer-reviewed publications in PubMed in the English language over a 30 year period between January 1980 and May 2010. Both retrospective and prospective studies were included, as well as meta-analyses. With regard to defining \\'topical\\' or \\'local\\' antibiotic application, the application of an antibiotic solution to the surgical site intraoperatively or immediately post-operatively was included. A number of surgical procedures have been shown to significantly benefit from perioperative topical prophylaxis, e.g. joint arthroplasty, cataract surgery and, possibly, breast augmentation. In obese patients undergoing abdominal surgery, topical surgical prophylaxis is also proven to be beneficial. The selective use of topical antibiotics as surgical prophylaxis is justified for specific procedures, such as joint arthroplasty, cataract surgery and, possibly, breast augmentation. In selective cases, such as obese patients undergoing abdominal surgery, topical surgical prophylaxis is also proven to be beneficial. Apart from these specific indications, the evidence for use of topical antibiotics in surgery is lacking in conclusive randomized controlled trials.

  15. Timeline interviews

    DEFF Research Database (Denmark)

    Adriansen, Hanne Kirstine

    2012-01-01

    The aim of this paper is to explain and discuss timeline interviews as a method for doing life history research. It is a ‘how to’ article explaining the strengths and weaknesses of using a timeline when conducting qualitative interviews. The method allows the interviewee to participate...... in the reporting of the interview which may give raise to ownership and sharing of the analytical power in the interview situation. Exactly for this reason, it may not be the most appropriate method for interviewing elites or for conducting insider interviews where positionality can be at play. The use...... of the timeline should not lead the nterviewer or the interviewee to assume linearity and coherence; it is an rganising principle for the events. It provides an opportunity for linking the story with the wider social, political and environmental context during the interview. hile the method is very suitable...

  16. Have We Come as Far as We Had Hoped? Discrimination in the Residency Interview.

    Science.gov (United States)

    Hessel, Kara; DiPasco, Peter; Kilgore, Lyndsey; Shelley, Casey; Perry, Alvin; Wagner, Jamie

    The primary objective was to use a pilot survey of fourth-year medical students at our institution to determine if female residency applicants were asked potentially illegal questions regarding family status and childbearing more frequently than male applicants. Secondary objectives included comparing the use of potentially illegal questions in surgical versus nonsurgical specialties and between community and academic residency programs. A 20-item questionnaire was distributed to all fourth-year medical students at the University of Kansas School of Medicine. Data were analyzed in SPSS using descriptive statistics, bivariate analysis, and multivariate analysis. University of Kansas Health System, Tertiary Care Center. Fourth-year medical students from the University of Kansas School of Medicine. There were 57 survey respondents (51% male and 49% female). Female applicants were more likely to report being asked about their desire to have a family than male applicants (32% vs. 3%, respectively, p = 0.041). However, male and female students were equally likely to report being asked specifically if they had or intended to have children (p = 0.194). No significant differences were found in potentially illegal question-asking between surgical and nonsurgical specialties or between community-based and academic programs. Although women now represent 47% of the applicant pool, gender discrimination in the residency interview has not been eradicated. Women are more likely to report potentially illegal questions regarding their desire to have a family on residency interviews than men. Community and academic programs appear to ask similar numbers and types of potentially illegal questions. Further study is warranted to determine if these findings apply to the entire applicant pool. Further education of interviewers is necessary regarding potentially illegal questions during the residency interview process. Copyright © 2017 Association of Program Directors in Surgery

  17. The Use of English as Ad Hoc Institutional Standard in the Belgian Asylum Interview

    Science.gov (United States)

    Maryns, Katrijn

    2017-01-01

    In institutional settings of globalization, labelled languages are generally preferred over multilingual repertoires and mobile language resources. Drawing on linguistic-ethnographic analysis of the way English is treated as an invariable "ad hoc" idiom in the Belgian asylum interview, this article demonstrates how institutional measures…

  18. Motivational Interviewing as a Supervision Strategy in Probation: A Randomized Effectiveness Trial

    Science.gov (United States)

    Walters, Scott T.; Vader, Amanda M.; Nguyen, Norma; Harris, T. Robert; Eells, Jennifer

    2010-01-01

    Motivational interviewing (MI) has been recommended as a supervision style in probation. This project examined the effectiveness of an MI training curriculum on probation officer MI skill and subsequent probationer outcome. Twenty probation officers were randomized to receive MI training, or to a waiting list control, while an additional group of…

  19. Using Motivational Interviewing as the Basis for a Peer Support Programme in High School

    Science.gov (United States)

    Channon, Sue; Marsh, Karen; Jenkins, Amy; Robling, Mike

    2013-01-01

    This paper reports on a peer support programme founded on the principles of Motivational Interviewing, a counselling method with a focus on exploring and helping to resolve ambivalence about behaviour change. Working with the staff and pupils of Ysgol Gyfun Gymraeg Plasmawr in South Wales UK, (referred to as Plasmawr) this work incorporated a…

  20. Interviewer-perceived honesty as a mediator of racial disparities in the diagnosis of schizophrenia.

    Science.gov (United States)

    Eack, Shaun M; Bahorik, Amber L; Newhill, Christina E; Neighbors, Harold W; Davis, Larry E

    2012-09-01

    African Americans are disproportionately diagnosed as having schizophrenia, and the factors that contribute to this disparity are poorly understood. This study utilized data from the 1995 MacArthur Violence Risk Assessment Study to examine the impact of racial differences in sociodemographic characteristics, clinical presentation, and perceived honesty on disparities in the diagnosis of schizophrenia among African Americans. Researchers using structured assessments of diagnostic, sociodemographic, and clinical measures interviewed African Americans (N=215) and whites (N=537) receiving inpatient care for a severe mental illness. The impact of interviewers' perceptions of the participants' honesty on racial disparities in the diagnosis of schizophrenia was assessed. African Americans (45%) were more than three times as likely as whites (19%) to be diagnosed as having schizophrenia. Disparities in sociodemographic and clinical characteristics modestly contributed to disparities in diagnostic rates. In contrast, interviewer-perceived honesty proved to be a significant predictor of racial disparities in schizophrenia diagnoses. After adjustment for perceived honesty, diagnostic disparities between African Americans and whites were substantially reduced. Mediator analyses confirmed that interviewer-perceived honesty was the only consistent mediator of the relationship between race and schizophrenia diagnosis. Interviewers' perceptions of honesty among African-American participants are important contributors to disparities in the diagnosis of schizophrenia. Clinicians' perceptions of dishonesty among African-American patients may reflect poor patient-clinician relationships. Methods of facilitating a trusting relationship between patients and clinicians are needed to improve the assessment and treatment of persons from minority groups who are seeking mental health care. (Psychiatric Services 63:875-880, 2012; doi: 10.1176/appi.ps.201100388).

  1. Safety and Feasibility of Topical Application of Limonene as a Massage Oil to the Breast.

    Science.gov (United States)

    Miller, Jessica A; Thompson, Patricia A; Hakim, Iman A; Lopez, Ana Maria; Thomson, Cynthia A; Chew, Wade; Hsu, Chiu-Hsieh; Chow, H-H Sherry

    2012-10-01

    Limonene, a major component in citrus oil, has demonstrated anti-cancer effects in preclinical mammary cancer models. However, the effective oral dose translates to a human dose that may not be feasible for chronic dosing. We proposed to evaluate topical application of limonene to the breast as an alternative dosing strategy. We conducted a mouse disposition study to determine whether limonene would be bio available in the mammary tissue after topical application. SKH-1 mice received topical or oral administration of limonene in the form of orange oil every day for 4 weeks. Plasma and mammary pads were collected 4 hrs after the final dosing. We also conducted an exploratory clinical study to evaluate the safety and feasibility of topically applied limonene in the form of orange oil to the breast. Healthy women were recruited to apply orange oil containing massage oil to their breasts daily for four weeks. Safety and feasibility were assessed by reported adverse events, clinical labs, and usage compliance. Pre and post-intervention nipple aspirate fluid (NAF) and plasma were collected for limonene concentration determination. The mouse disposition study showed that topical and oral orange oil administration resulted in similar mammary tissue disposition of limonene with no clinical signs of toxicity. In the clinical study, the topical application of limonene containing massage oil to the breast was found to be safe with high levels of usage compliance for daily application, although NAF and plasma limonene concentrations were not significantly changed after the massage oil application. Our studies showed that limonene is bio available in mammary tissue after topical orange oil application in mice and this novel route of administration to the breast is safe and feasible in healthy women.

  2. “En tu casa o en la mía’: the interview as infotainment

    Directory of Open Access Journals (Sweden)

    Marián Alonso González

    2016-11-01

    Full Text Available The fight for viewers has led to a spectacular range of television content on offer where boundaries of genres have disappeared giving rise to new formats of hybrid television programmes. This has given a new lease of life to interviews as a genre of infotainment. The present article analyses the programme ‘En tu casa o en la mía’, a new type of interview of famous personalities which combines information and entertainment with elements that are very similar to the info-show. We shall embark on a study of this media product, its narrative, treatment, structure and the technique used so as to describe the elements that make it an example of gender hybridization in today’s television programmes.

  3. Drug abuse and change readiness in prisoners : effect of motivational interviewing as measured by SOCRATES

    OpenAIRE

    Dahl, Helene M.

    2008-01-01

    The effect of Motivational Interviewing (MI) was evaluated in a sample of incarcerated substance abusers, using the Stages of Change Readiness and Treatment Eagerness Scale (SOCRATES). The design was a pre-post between-groups design. To explore the importance of feedback in MI-training participants (N = 98) were randomized to two conditions that differed in terms of feedback or no feedback to the counsellor, and received five sessions of MI. As predicted, the results indicated a significant o...

  4. [Puppets as a resource for in-depth interviews with pre-school children].

    Science.gov (United States)

    González-Gil, Teresa

    2007-01-01

    Doing research about children health and illness process involves to consider their own experience interpretation, so that listening to children's voice in necessary. Qualitative research offers us the possibility to access children's subjective experience. Nevertheless doing research with children is not easy and sometimes the use of support tools is necessary. This article goes in depth into the use of puppets as an strategy to carry out in-depth interviews with preschools.

  5. Interview as a tool to obtain information in qualitative research strategy

    OpenAIRE

    I V Chekhovskiy

    2009-01-01

    The axis of the publication is the endeavor involving the description of one of three universal methods of sociological data collection, i.e. the interview. The interview method is viewed in the context of the change in the extent to which the interview procedure is formalized. Other underlying principles of the classification of diverse practices of sociological interview are provided in this very item. Special attention is given to the roles of interviewer and respondent in the course of th...

  6. The Role of Web Interviews as Part of a National Travel Survey

    DEFF Research Database (Denmark)

    Christensen, Linda

    2013-01-01

    Purpose — The paper is analysing the effect of adding a web survey to a traditional telephone-based national travel survey by asking the respondents to check in on the web and answer the questions there (Computer Assisted Web Interview, CAWI). If they are not participating by web they are as usual...... called by telephone (Computer Assisted Telephone Interview, CATI). Design/methodology/approach — Multivariate regression analyses are used to analyse the difference in response rates by the two media and to analyse if respondents’ answering by the two media have different travel patterns. Findings...... and of highly educated. And it is offering a higher flexibility to answer after a couple of days off. The CATI is on the other hand more useful for the elderly. In addition, the CATI survey proved to be more useful for busy people and people not willing to participate in a survey at all. Young people and people...

  7. The Use of Videoconferencing as a Medium for the Qualitative Interview

    Directory of Open Access Journals (Sweden)

    Monique Sedgwick RN, PhD

    2009-03-01

    Full Text Available Qualitative data collection, especially conducting in-person interviews, presents challenges for researchers whose participants are geographically dispersed. Often alternative means of interviewing using communication technology are necessary. This was true for this focused ethnographic research exploring the experiences of participants who were connected to a particular cultural group by virtue of their similar experience but who were not located in the same geographical area. The purpose of this paper is to present the experience of using videoconferencing technology to collect experiential data from undergraduate nursing students and preceptors who were dispersed over a 640,000 square kilometer area in western and northern Canada during a rural hospital-based preceptorship. Recommendations for using videoconferencing as a medium for conducting in-depth qualitative interviews include using a high-bandwidth connection such as SuperNet or Web conferencing, and evaluating whether the type of information sought is likely to be shared in other than in-person face-to-face situations.

  8. An Abnormal Psychology Community Based Interview Assignment

    Science.gov (United States)

    White, Geoffry D.

    1977-01-01

    A course option in abnormal psychology involves students in interviewing and observing the activities of individuals in the off-campus community who are concerned with some aspect of abnormal psychology. The technique generates student interest in the field when they interview people about topics such as drug abuse, transsexualism, and abuse of…

  9. Telephone and Face-to-Face Interviews with Low-Income Males with Child Care Responsibilities Support Inclusion as a Target Audience in SNAP-Ed.

    Science.gov (United States)

    Krall, Jodi Stotts; Wamboldt, Patricia; Lohse, Barbara

    2015-06-01

    Federally funded nutrition programs mostly target females. Changes in family dynamics suggest low-income men have an important role in food management responsibilities. The purpose of this study was to inform nutrition education program planning to meet needs of lower-income males. Cross-sectional telephone and face-to-face interviews. Stratified random sample of men (n = 101), 18-59 years of age, with child care responsibilities, living in households participating in the Supplemental Nutrition Assistance Program and a convenience sample of adult males (n = 25) recruited from lower income venues. (1) Scripted telephone interviews about health status, eating behaviors, eating competence, food security, technology usage and topics and strategies for nutrition education. (2) In-person cognitive interviews during review of selected online nutrition education lessons. Nutrition education topics of interest, preferred educational strategies, influences on and barriers to intake, eating competence, critiques of online program content, graphics, format. Bivariate correlations, independent t tests, one-way analysis of variance or Chi square, as appropriate. Thematic analyses of cognitive interviews. Of telephone interviewees, 92.1% prepared meals/snacks for children and 54.5% made major household food decisions. Taste was the greatest influence on food selection and the greatest barrier to eating healthful foods. Topics of highest interest were "which foods are best for kids" and "how to eat more healthy foods." Preferred nutrition education strategies included online delivery. Online lessons were highly rated. Interactive components were recognized as particularly appealing; enhanced male centricity of lessons was supported. Findings provided compelling evidence for including needs specific to low-income males when planning, designing, and funding nutrition education programs.

  10. Interview as a tool to obtain information in qualitative research strategy

    Directory of Open Access Journals (Sweden)

    I V Chekhovskiy

    2009-12-01

    Full Text Available The axis of the publication is the endeavor involving the description of one of three universal methods of sociological data collection, i.e. the interview. The interview method is viewed in the context of the change in the extent to which the interview procedure is formalized. Other underlying principles of the classification of diverse practices of sociological interview are provided in this very item. Special attention is given to the roles of interviewer and respondent in the course of the interview.

  11. Canada as an Immigrant Nation: Implications for Educators Excerpts from an Interview with John Ralston Saul

    Science.gov (United States)

    Education Canada, 2011

    2011-01-01

    This article presents an interview with John Ralston Saul, one of Canada's pre-eminent thinkers. In the interview, Mr. Saul shares his provocative and compelling thoughts on the state of Canada's public education systems.

  12. Topical fluoroquinolone use as a risk factor for in vitro fluoroquinolone resistance in ocular cultures.

    Science.gov (United States)

    Fintelmann, Robert E; Hoskins, Eliza N; Lietman, Thomas M; Keenan, Jeremy D; Gaynor, Bruce D; Cevallos, Vicky; Acharya, Nisha R

    2011-04-01

    To determine whether recent use of topical fluoroquinolones is a risk factor for in vitro fluoroquinolone resistance in Staphylococcus aureus ocular isolates. Disk diffusion susceptibility testing for ciprofloxacin, moxifloxacin, and gatifloxacin was performed for all ocular isolates of S aureus at the Francis I. Proctor Foundation microbiology laboratory from January 1, 2005, to December 31, 2008. The medical records of patients with positive S aureus cultures were reviewed to determine topical or systemic fluoroquinolone use within the 3 months prior to culture. The Fisher exact test was used to compare the proportion of patients who used topical fluoroquinolones in the past 3 months among fluoroquinolone-sensitive and -resistant cases. Logistic regression was used to determine risk factors for fluoroquinolone resistance. Of 200 S aureus cultures, 41 were resistant to ciprofloxacin, moxifloxacin, and gatifloxacin (20.5%). Fluoroquinolone-resistant S aureus isolates were from older patients (mean [SD] age, 65.5 [25.0] years) compared with fluoroquinolone-susceptible isolates (mean [SD] patient age, 52.1 [22.1] years) (P = .003). Use of fluoroquinolones within the 3 months before testing was more frequent in resistant isolates (29%) than in susceptible isolates (11%) (P = .005), as was recent hospitalization (22% of resistant isolates, 0% of susceptible isolates) (P fluoroquinolone use within 3 months was a significant predictor of fluoroquinolone resistance (P = .046), along with age, systemic immunosuppression, and topical fluoroquinolone use between 3 and 6 months before testing. Recent topical fluoroquinolone use is significantly associated with fluoroquinolone resistance in S aureus isolates from ocular cultures.

  13. Counseling as a Stochastic Process: Fitting a Markov Chain Model to Initial Counseling Interviews

    Science.gov (United States)

    Lichtenberg, James W.; Hummel, Thomas J.

    1976-01-01

    The goodness of fit of a first-order Markov chain model to six counseling interviews was assessed by using chi-square tests of homogeneity and simulating sampling distributions of selected process characteristics against which the same characteristics in the actual interviews were compared. The model fit four of the interviews. Presented at AERA,…

  14. Topical application of entry inhibitors as "virustats" to prevent sexual transmission of HIV infection

    Directory of Open Access Journals (Sweden)

    Root Michael

    2008-12-01

    Full Text Available Abstract With the continuing march of the AIDS epidemic and little hope for an effective vaccine in the near future, work to develop a topical strategy to prevent HIV infection is increasingly important. This stated, the track record of large scale "microbicide" trials has been disappointing with nonspecific inhibitors either failing to protect women from infection or even increasing HIV acquisition. Newer strategies that target directly the elements needed for viral entry into cells have shown promise in non-human primate models of HIV transmission and as these agents have not yet been broadly introduced in regions of highest HIV prevalence, they are particularly attractive for prophylaxis. We review here the agents that can block HIV cellular entry and that show promise as topical strategies or "virustats" to prevent mucosal transmission of HIV infection

  15. In vitro analysis of polyurethane foam as a topical hemostatic agent.

    Science.gov (United States)

    Broekema, Ferdinand I; van Oeveren, Wim; Zuidema, Johan; Visscher, Susan H; Bos, Rudolf R M

    2011-04-01

    Topical hemostatic agents can be used to treat problematic bleedings in patients who undergo surgery. Widely used are the collagen- and gelatin-based hemostats. This study aimed to develop a fully synthetic, biodegradable hemostatic agent to avoid exposure to animal antigens. In this in vitro study the suitability of different newly developed polyurethane-based foams as a hemostatic agent has been evaluated and compared to commonly used agents. An experimental in vitro test model was used in which human blood flowed through the test material. Different modified polyurethane foams were compared to collagen and gelatin. The best coagulation was achieved with collagen. The results of the polyurethane foam improved significantly by increasing the amount of polyethylene glycol. Therefore, the increase of the PEG concentration seems a promising approach. Additional in vivo studies will have to be implemented to assess the application of polyurethane foam as a topical hemostatic agent.

  16. Infection control as a topic for ward-based nursing education.

    Science.gov (United States)

    Gould, D; Chamberlain, A

    1994-08-01

    The link between nursing theory and practice remains a topic of ongoing debate. Related to this issue is the best place to effectively combine the two. The solution may be ward-based teaching programmes as part of formal continuing staff development, involving collaboration between college-based lecturers and acknowledged clinical experts. Using infection control as an example of a topic in need of regular and continual updating for qualified practitioners, it is argued that such programmes would be desirable because they would afford sufficient flexibility to fulfil individual learning needs and could be assessed to indicate whether nursing practice had been enhanced. Participants could be accredited for successful completion of ward-based programmes.

  17. Final Technical Report summarizing Purdue research activities as part of the DOE JET Topical Collaboration

    Energy Technology Data Exchange (ETDEWEB)

    Molnar, Denes [Purdue Univ., West Lafayette, IN (United States). Dept. of Physics and Astronomy

    2015-09-01

    This report summarizes research activities at Purdue University done as part of the DOE JET Topical Collaboration. These mainly involve calculation of covariant radiative energy loss in the (Djordjevic-)Gyulassy-Levai-Vitev ((D)GLV) framework for relativistic A+A reactions at RHIC and LHC energies using realistic bulk medium evolution with both transverse and longitudinal expansion. The single PDF file provided also includes a report from the entire JET Collaboration.

  18. Final Technical Report summarizing Purdue research activities as part of the DOE JET Topical Collaboration

    International Nuclear Information System (INIS)

    Molnar, Denes

    2015-01-01

    This report summarizes research activities at Purdue University done as part of the DOE JET Topical Collaboration. These mainly involve calculation of covariant radiative energy loss in the (Djordjevic-)Gyulassy-Levai-Vitev ((D)GLV) framework for relativistic A+A reactions at RHIC and LHC energies using realistic bulk medium evolution with both transverse and longitudinal expansion. The single PDF file provided also includes a report from the entire JET Collaboration.

  19. Interview with Danny Kaplan

    Science.gov (United States)

    Rossman, Allan; Kaplan, Danny

    2017-01-01

    Danny Kaplan is DeWitt Wallace Professor of Mathematics and Computer Science at Macalester College. He received Macalester's Excellence in teaching Award in 2006 and the CAUSE/USCOTS Lifetime Achievement Award in 2017. This interview took place via email on March 4-June 17, 2017. Topics covered in the interview include: (1) the current state of…

  20. Microemulsions as vehicles for topical administration of voriconazole: formulation and in vitro evaluation.

    Science.gov (United States)

    El-Hadidy, Gladious Naguib; Ibrahim, Howida Kamal; Mohamed, Magdi Ibrahim; El-Milligi, Mohamed Farid

    2012-01-01

    This work was undertaken to investigate microemulsion (ME) as a topical delivery system for the poorly water-soluble voriconazole. Different ME components were selected for the preparation of plain ME systems with suitable rheological properties for topical use. Two permeation enhancers were incorporated, namely sodium deoxycholate or oleic acid. Drug-loaded MEs were evaluated for their physical appearance, pH, rheological properties and in vitro permeation studies using guinea pig skin. MEs based on polyoxyethylene(10)oleyl ether (Brij 97) as the surfactant showed pseudoplastic flow with thixotropic behavior and were loaded with voriconazole. Jojoba oil-based MEs successfully prolonged voriconazole release up to 4 h. No significant changes in physical or rheological properties were recorded on storage for 12 months at ambient conditions. The presence of permeation enhancers favored transdermal rather than dermal delivery. Sodium deoxycholate was more effective than oleic acid for enhancing the voriconazole permeation. Voriconazole-loaded MEs, with and without enhancers, showed significantly better antifungal activity against Candida albicans than voriconazole supersaturated solution. In conclusion, the studied ME formulae could be promising vehicles for topical delivery of voriconazole.

  1. Citizen journalism is as old as journalism itself: An interview with Stuart Allan

    OpenAIRE

    Hajek, Roman; Stefanikova, Sandra; Allan, Stuart

    2014-01-01

    Professor Stuart Allan from Cardiff University in the UK is one of the leading scholars\\ud in contemporary journalism studies. He has made a significant contribution to the development\\ud of this research field, having authored or edited seventeen books to date (many\\ud of which have been translated into multiple languages), as well as a wide range of journal\\ud articles and book chapters. He is a co-founder of the peer-reviewed journal Journalism\\ud Education, and serves on the editorial boa...

  2. Public Participation Guide: Stakeholder Interviews

    Science.gov (United States)

    Interviews with stakeholders are one-to-one conversations about a specific topic or issue. The primary purpose of these interviews is to obtain project-relevant information and elicit stakeholder reactions and suggestions.

  3. Treating umbilical granuloma with topical clobetasol propionate cream at home is as effective as treating it with topical silver nitrate in the clinic

    DEFF Research Database (Denmark)

    Brødsgaard, Anne; Nielsen, Tove; Mølgaard, Ulla

    2015-01-01

    AIM: There is a lack of evidence on the best treatment option for umbilical granuloma. The primary aim of this study was to compare three treatments for umbilical granuloma: standard treatment with topical silver nitrate, clobetasol propionate cream (0.05%) and ethanol wipes. The secondary aim......%) in the outpatient clinic, 30 infants had topical clobetasol propionate cream (0.05%) applied at home, and 34 infants received cleansing with ethanol wipes (82%) at home. RESULTS: Silver nitrate and clobetasol propionate cream (0.05%) were significantly superior to ethanol wipes, with shorter healing times...... and higher resolution rates (p = 0.0001). Healing time and resolution rates were identical for silver nitrate and clobetasol propionate cream (0.05%). Mild side effects were occasionally reported, all of which were self-limiting. CONCLUSION: Treating umbilical granuloma with topical clobetasol propionate...

  4. Time as a Key Topic in Health Professionals’ Perceptions of Clinical Handovers

    OpenAIRE

    Bernadette M. Watson; Liz Jones; Julia Cretchley

    2014-01-01

    Clinical handovers are an essential part of the daily care and treatment of hospital patients. We invoked a language and social psychology lens to investigate how different health professional groups discussed the communication problems and strengths they experienced in handovers. We conducted in-depth interviews with three different health professional groups within a large metropolitan hospital. We used Leximancer text analytics software as a tool to analyze the data. Results showed that ti...

  5. Choosing "Something Else" as a Sexual Identity: Evaluating Response Options on the National Health Interview Survey.

    Science.gov (United States)

    Eliason, Michele J; Streed, Carl G

    2017-10-01

    Researchers struggle to find effective ways to measure sexual and gender identities to determine whether there are health differences among subsets of the LGBTQ+ population. This study examines responses on the National Health Interview Survey (NHIS) sexual identity questions among 277 LGBTQ+ healthcare providers. Eighteen percent indicated that their sexual identity was "something else" on the first question, and 57% of those also selected "something else" on the second question. Half of the genderqueer/gender variant participants and 100% of transgender-identified participants selected "something else" as their sexual identity. The NHIS question does not allow all respondents in LGBTQ+ populations to be categorized, thus we are potentially missing vital health disparity information about subsets of the LGBTQ+ population.

  6. Tough Teens: The Methodological Challenges of Interviewing Teenagers as Research Participants

    Science.gov (United States)

    Bassett, Raewyn; Beagan, Brenda L.; Ristovski-Slijepcevic, Svetlana; Chapman, Gwen E.

    2008-01-01

    Encouraging a teenager to have a conversation in a semistructured research interview is fraught with difficulties. The authors discuss the methodological challenges encountered when interviewing adolescents of European Canadian, African Canadian, and Punjabi Canadian families who took part in the Family Food Decision-Making Study in two regions of…

  7. An Introduction to Topic Modeling as an Unsupervised Machine Learning Way to Organize Text Information

    Science.gov (United States)

    Snyder, Robin M.

    2015-01-01

    The field of topic modeling has become increasingly important over the past few years. Topic modeling is an unsupervised machine learning way to organize text (or image or DNA, etc.) information such that related pieces of text can be identified. This paper/session will present/discuss the current state of topic modeling, why it is important, and…

  8. Ototoxicity associated with topical administration of diclofenac sodium as an otic drop: An experimental animal study.

    Science.gov (United States)

    Acioglu, Engin; Yigit, Ozgur; Onur, Firat; Atas, Ahmet; Server, Ela Araz; Kara, Eyup

    2017-07-01

    The aim of the study is to evaluate the ototoxicity of topical diclofenac sodium in comparison to positive and negative controls prior to the investigation of analgesic and anti-inflammatory efficacy of the agent in otic administration. Twenty four ears of 12 guinea pigs were included in the study. Wide myringotomy was performed on all tympanic membranes under general anesthesia and auditory brainstem responses (ABR) were evaluated. The subjects were separated into four groups, two groups received diclofenac sodium at low and high doses, positive controls received gentamicin and negative controls received isotonic sodium chloride topically for 14 days and ABRs were reevaluated. No significant difference were observed between the pre and post-treatment click response, 1 kHz and 8 kHz response threshold levels after isotonic sodium chloride administration. All threshold levels were elevated in the positive control group. In the low and high dose diclofenac sodium groups, click response, 1 kHz and 8 kHz response threshold levels were significantly higher compared to the baseline values. Pre and post-treatment mean threshold level changes were not significantly different between the low and high dose diclofenac sodium groups. Pre and post-treatment mean threshold level changes in the gentamicin group were not significantly different from low or high dose diclofenac sodium groups. Diclofenac sodium, considered as an analgesic and anti-inflammatory otic preparation, is shown to be as ototoxic as gentamicin in chronic use which may lead to loss of hearing especially when used topically in chronic otitis cases with tympanic membrane damage. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. Avoidance as a strategy of (not coping: qualitative interviews with carers of Huntington's Disease patients

    Directory of Open Access Journals (Sweden)

    van Teijlingen Edwin R

    2005-09-01

    Full Text Available Abstract Background Since Huntington's Disease (HD is a familial disease with an average onset in the mid-thirties, one might expect that spousal carers are concerned with providing care for off-spring who may turn out to be affected. Methods This study involved ten face-to-face interviews with carers of spouses affected by HD in Northeast Scotland. Carers were recruited through two channels: a genetic clinic and the Scottish Huntington's Association (SHA. Interviews were conducted in carers' own homes. A thematic analysis of the transcripts was conducted. Results Although carers did worry about their children, they did not envisage being involved in their care. Many avoided talking about the disease, both within and outwith their family; this may have greatly reduced the level of support provided by family members. Conversely, avoidance was often accompanied by symptom-spotting. For example, several people had given up driving, before they were incapable of doing so. The explanation appears to be that they avoided getting into situations in which HD may express itself. Support meetings seem to be valued amongst patients with other serious diseases and their carers, however, although all participants had had contact with the SHA, only one regularly attended meetings. It was felt that seeing others with HD provided a constant reminder of the possible effect of HD on the wider family, which seemed to outweigh the benefit of attending. Overall, the analysis highlighted 'avoidance' as a key theme. Conclusion Many denied symptoms of HD in their spouses, pre-diagnosis. All had pretended at some point that it was not happening, through ignoring early signs and 'obvious' symptoms. Some partners had refused to go to the doctor until it was no longer possible to deny symptoms. Formal health and social care seemed to play a very small role compared to informal care arrangements.

  10. Production of nanosuspensions as a tool to improve drug bioavailability: focus on topical delivery.

    Science.gov (United States)

    Lai, Francesco; Schlich, Michele; Pireddu, Rosa; Corrias, Francesco; Fadda, Anna Maria; Sinico, Chiara

    2015-01-01

    Over the past two decades nanosizing technology has become one of the most successful formulation approaches for improving the bioavailability of poorly soluble drugs, which show a low oral absorption due to low dissolution velocity. Nanocrystals are nanoparticles of pure drug, without any matrix material, with an average diameter below 1 µm (typically in the range of 200-500 nm), which can be prepared in both water and non-water media as colloidal nanosuspensions stabilized using surfactants or polymers. The reduction of the drug particle diameter below 1 µm increases the dissolution velocity by increasing the particle surface and decreasing the diffusion layer thickness. Nanosuspension production processes involve two different approaches such as bottom-up (drug nanocrystal precipitation) and top-down (drug particle disintegration) technologies or a combination of two. Within these main approaches, a variety of possible techniques to achieve particle size reduction have been proposed by different research groups from both industry and academia. Even though nanosuspensions formulations have been especially studied for oral and parenteral administration, nanocrystals have showed a great potential also for topical delivery through alternative routes such as dermal, pulmonary and ocular route. The purpose of this review is to describe the main technologies used to produce nanosuspensions as well as to explore the most significant results and progresses obtained by application of drug nanocrystal formulations through topical routes.

  11. Topical ayurvedic ointment-induced chemical injury presenting as bilateral acute keratitis.

    Science.gov (United States)

    Sahay, Pranita; Saluja, Gunjan; Maharana, Prafulla Kumar; Titiyal, Jeewan S

    2017-08-20

    A 40-years-old female patient was referred to the cornea clinic as a probable case of bilateral keratitis. The patient had a history of headache followed by acute onset of redness, pain and discharge from both eyes for 15 days. The patient was diagnosed as bilateral keratitis by the first contact physician and was started on topical antibiotics, cycloplegics and lubricating eye-drops. At presentation, both eyes had visual acuity of perception of light, conjunctival congestion, limbal blanching, diffuse corneal oedema and epithelial defect. A detailed history revealed application of Vicks VapoRub [topical ayurvedic analgesic which contains (per 100 g of product) menthol (2.82 g), camphor (5.25 g) and eucalyptol (1.49 mL) and excipients include thymol (0.1 g), turpentine oil (5.57 mL), nutmeg oil (0.54 mL), cedar wood oil and petrolatum)] on the forehead and eyelids for headache several times over 2-3 days before the onset. The patient further confirmed the accidental application of the ointment in the eyes. A provisional diagnosis of acute chemical injury with Vicks VapoRub was made and treatment with topical antibiotic, cycloplegic, steroid, lubricant and vitamin C was started. On follow-up, both eyes showed gradual resolution of corneal oedema and epithelial defect. Visual acuity improved in the left eye to 6/60 with no change in right eye due to corneal haze. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  12. Comparative Study between topical applications liposomally entrapped DNA repair enzymes and thymidine dinucleotide as radioprotectors

    International Nuclear Information System (INIS)

    Shabon, M.H.; El-Bedewi, A.F.

    2005-01-01

    The delivery of active agents to the skin by liposome carriers received great interest during the last three decades. This is based on their potential to enclose various types of biological materials and to deliver them to diverse cell types. Recent work suggests that liposomes as vehicles for topical drug delivery may be superior to conventional preparations. Also, topical application of DNA repair enzymes to irradiated skin increases the rate of repair of DNA potentially damaged cells. Moreover, thymidine dinucleotide is a new skin photo-protective agent against non-ionizing radiation through induction of DNA repair. Gamma irradiation can produce DNA damage in human skin. DNA mutations have an important role in the development of skin cancer and precancerous skin lesions. Albino rats were irradiated with Cobalt-60 gamma radiation with different doses (0.5, 1.5, 3 Gy), and were treated by either thymidine dinucleotide or liposomally entrapped DNA repair enzymes topically 24 hours before irradiation. Evaluation was done histopathologically by H and E stain. Computerized image analyzer using Masson's trichrome stain was also done. Gamma radiation produced epidermal thinning and dermal inflammatory cells together with collagen fragmentation and clumping in a dose-dependent manner. Comparing between both thymidine dinucleotide and liposomally entrapped DNA repair enzymes pretreated and irradiated rats. Low dose irradiation (0.5 Gy) together with previous drugs showed preservation of epidermis with no inflammatory cells and also it maintained the normal architecture of collagen bundles. However, they were ineffective with higher doses. In conclusion our results may suggest that the effects of gamma radiation on the skin at low dose could be minimized by the use of these drugs before exposure

  13. JAK3 as an Emerging Target for Topical Treatment of Inflammatory Skin Diseases.

    Directory of Open Access Journals (Sweden)

    Ana Karina Alves de Medeiros

    Full Text Available The recent interest and elucidation of the JAK/STAT signaling pathway created new targets for the treatment of inflammatory skin diseases (ISDs. JAK inhibitors in oral and topical formulations have shown beneficial results in psoriasis and alopecia areata. Patients suffering from other ISDs might also benefit from JAK inhibition. Given the development of specific JAK inhibitors, the expression patterns of JAKs in different ISDs needs to be clarified. We aimed to analyze the expression of JAK/STAT family members in a set of prevalent ISDs: psoriasis, lichen planus (LP, cutaneous lupus erythematosus (CLE, atopic dermatitis (AD, pyoderma gangrenosum (PG and alopecia areata (AA versus healthy controls for (pJAK1, (pJAK2, (pJAK3, (pTYK2, pSTAT1, pSTAT2 and pSTAT3. The epidermis carried in all ISDs, except for CLE, a strong JAK3 signature. The dermal infiltrate showed a more diverse expression pattern. JAK1, JAK2 and JAK3 were significantly overexpressed in PG and AD suggesting the need for pan-JAK inhibitors. In contrast, psoriasis and LP showed only JAK1 and JAK3 upregulation, while AA and CLE were characterized by a single dermal JAK signal (pJAK3 and pJAK1, respectively. This indicates that the latter diseases may benefit from more targeted JAK inhibitors. Our in vitro keratinocyte psoriasis model displayed reversal of the psoriatic JAK profile following tofacitinib treatment. This direct interaction with keratinocytes may decrease the need for deep skin penetration of topical JAK inhibitors in order to exert its effects on dermal immune cells. In conclusion, these results point to the important contribution of the JAK/STAT pathway in several ISDs. Considering the epidermal JAK3 expression levels, great interest should go to the investigation of topical JAK3 inhibitors as therapeutic option of ISDs.

  14. Topical Yunnan Baiyao administration as an adjunctive therapy for bleeding complications in adolescents with advanced cancer.

    Science.gov (United States)

    Ladas, E J; Karlik, J B; Rooney, D; Taromina, K; Ndao, D H; Granowetter, L; Kelly, K M

    2012-12-01

    Yunnan Baiyao (White Medicine from Yunnan, YNB) is a Chinese herbal medicinal powder used to stop bleeding and improve circulation in traumatic injuries. We describe the use of YNB in adolescents with cancer as an adjunct to uncontrolled bleeding in the palliative care setting. Through a retrospective chart review of all patients receiving integrative medicine consultations at the Integrative Therapies Program at Columbia University from January 1, 2007 to January 31, 2012, we describe the outcome of patients treated with YNB for management of uncontrolled bleeding. Four patients were identified who received topical YNB for uncontrolled bleeding; patients included two males and two females with diagnoses of solid tumors (n = 3) and Burkitt's lymphoma (n = 1). Mean age was 15.5 years (range 15-17). Fifty percent had life-threatening bleeding from the tumor site and 50 % experienced uncontrollable epistaxis. All patients received preceding therapy with packed red blood cells and platelet transfusions, topical thrombin, and oral aminocaproic acid. Two patients used YNB in the inpatient setting, and all four patients used YNB as outpatients. In all patients, bleeding control improved with the addition of YNB to conventional hemostatic interventions. Two patients using YNB in their home reported control of bleeding episodes. There were no adverse events reported. YNB may be an efficacious agent for uncontrolled bleeding in conjunction with conventional hemostatic agents in adolescents with advanced cancer. It is well accepted by patients. YNB may be especially valuable in the outpatient setting to prevent the recurrence of hemorrhage.

  15. Chitosan-solid lipid nanoparticles as carriers for topical delivery of tretinoin.

    Science.gov (United States)

    Ridolfi, Daniela M; Marcato, Priscyla D; Justo, Giselle Z; Cordi, Lívia; Machado, Daisy; Durán, Nelson

    2012-05-01

    Tretinoin (TRE) or all-trans retinoic acid is employed in the topical treatment of various skin diseases including acne and psoriasis. However, its use is strongly limited by side effects and high chemical instability. TRE encapsulation in nanostructured systems reduces these problems. Chitosan is a biopolymer that exhibits a number of interesting properties such as bioadhesion and antibacterial activity. The aim of this work was to prepare and characterize solid lipid nanoparticles (SLN) containing TRE, with and without addition of chitosan, to assess their in vitro cytotoxicity in keratinocytes and to evaluate their antibacterial activity against bacteria related to acne. SLN without (SLN-TRE) and with (SLN-chitosan-TRE) chitosan were prepared by hot high pressure homogenization. The hydrodynamic mean diameter and zeta potential were 162.7±1.4 nm and -31.9±2.0 mV for SLN-TRE, and 284.8±15.0 nm and 55.9±3.1 mV for SLN-chitosan-TRE. The SLN-chitosan-TRE exhibited high encapsulation efficiency, high physical stability in the tested period (one year), were not cytotoxic to keratinocytes and showed high antibacterial activity against P. acnes and S. aureus. Therefore chitosan-SLN can be good candidates to encapsulate TRE and to increase its therapeutic efficacy in the topical treatment of acne. Copyright © 2011 Elsevier B.V. All rights reserved.

  16. Topical probiotics as a therapeutic alternative for chronic rhinosinusitis: A preclinical proof of concept.

    Science.gov (United States)

    Schwartz, Joseph S; Peres, Adam G; Mfuna Endam, Leandra; Cousineau, Benoit; Madrenas, Joaquin; Desrosiers, Martin

    2016-11-01

    Patients with chronic rhinosinusitis (CRS) have been shown to manifest a high inflammatory phenotype, with a sinus microbiome deficient in gram-positive bacteria. Gram-positive bacteria are capable of downregulating proinflammatory host responses via an interleukin (IL) 10 mediated response and may represent a potential therapeutic alternative for CRS. We wanted to (i) immunoprofile the IL-10 induction capacity of two gram-positive probiotic strains and (ii) verify the tolerance of these strains by the sinus epithelium. A peripheral blood mononuclear cell (PBMC) challenge model was used to document probiotic induction of IL-10 and tumor necrosis factor (TNF) alpha responses at various bacterial dilutions. Epithelial cell tolerance was demonstrated by using a primary epithelial cell model derived from patient biopsy specimens (six patients total [three with CRS and three controls]). After an incubation period with either a live or a heat-killed probiotic strain, cell viability was assessed by using light microscopy. Both probiotic strains induced high IL-10 secretion in PBMCs, with differing profiles of TNF alpha production. Microscopic evaluation after probiotic incubation demonstrated intact cell viability for all cell cultures. We identified well-tolerated, nonpathogenic, "generally recognized as safe" status gram-positive probiotics with anti-inflammatory properties. Topical probiotics represented a potential novel topical therapeutic strategy for CRS relevant for further clinical evaluation.

  17. Brief motivational interviewing as a clinical strategy to promote asthma medication adherence.

    Science.gov (United States)

    Borrelli, Belinda; Riekert, Kristin A; Weinstein, Andrew; Rathier, Lucille

    2007-11-01

    Patient-centered approaches are associated with better patient retention and treatment outcomes, without increased time and cost. Motivational interviewing (MI) is a patient-centered counseling approach that can be briefly integrated into patient encounters and is specifically designed to enhance motivation to change among patients not ready to change. Existing asthma management approaches (eg, education and self-management) increase resistance among patients not ready or willing to follow medical recommendations. MI helps patients resolve their ambivalence about behavior change and builds their intrinsic motivation before providing education. Although MI overlaps with patient-centered communication, it additionally includes some concrete motivational strategies that can be briefly and easily implemented in medical settings (eg, setting an agenda, assessing motivation and confidence for change, helping the patient weigh the costs and benefits of change, and providing medical advice and health feedback). Reflective listening is used to help patients clarify their ambivalence and diffuse resistance. MI has been shown to be efficacious across a wide variety of health behavior change areas. This article will describe the method and spirit of MI as applied to asthma management by reviewing the principles of MI, brief MI strategies to motivate medication adherence, the evidence base for MI, and the costs and benefits of building MI into clinical practice.

  18. Using the Technology of the Confessional as an Analytical Resource: Four Analytical Stances Towards Research Interviews in Discourse Analysis

    Directory of Open Access Journals (Sweden)

    Brendan K. O'Rourke

    2007-05-01

    Full Text Available Among the various approaches that have developed from FOUCAULT's work is an Anglophone discourse analysis that has attempted to combine FOUCAULTian insights with the techniques of Conversation Analysis. An important current methodological issue in this discourse analytical approach is its theoretical preference for "naturally occurring" rather than research interview data. A FOUCAULTian perspective on the interview as a research instrument, questions the idea of "naturally-occurring discourse". The "technology of the confessional" operates, not only within research interviews, but permeates other interactions as well. Drawing on FOUCAULT does not dismiss the problems of the interview as research instrument rather it shows they cannot be escaped by simply switching to more "natural" interactions. Combining these insights with recent developments within discourse analysis can provide analytical resources for, rather than barriers to, the discourse analysis of research interviews. To aid such an approach, we develop a four-way categorisation of analytical stances towards the research interview in discourse analysis. A demonstration of how a research interview might be subjected to a discourse analysis using elements of this approach is then provided. URN: urn:nbn:de:0114-fqs070238

  19. Tactile Models and Games as Learning Tools for Topics of Molecular and Cell Biology

    Directory of Open Access Journals (Sweden)

    Nelma Regina Segnini Bossolan

    2017-07-01

    Full Text Available The cell structure and the dynamics of its functioning are basic topics for the understanding of phenomena on a larger scale in living organisms and for which research in science teaching has suggested several strategies based on the use of images, games, computational simulations and tactile models, among other types of external representations. Our science education research group, over the last 17 years, has developed and evaluated educational materials for teaching these topics, aimed at all levels of school. Among these materials, we highlight the tactile models for the assembly of nucleic acid, amino acids and proteins molecules, as well as a board game that deals with the process of protein synthesis. These materials were evaluated with students from the final grades of elementary and high school, in the context of the Natural Sciences Curriculum of the State of São Paulo, as well as students from two higher level courses, one of them Licentiate’s program in Exact Sciences. Activities were planned with a problem-solving approach and carried out in small groups. Tactile models of nucleic acid aided elementary students in understanding the role of these molecules in the transmission of hereditary traits. The game of protein synthesis, which depicts this process in a schematic eukaryotic cell where the participants aim to synthesize a particular protein, promoted the development of skills such as “decision making” and “making anticipations” among high school students, in addition of expanding their knowledge about the biological functions of these molecules. The tactile models of amino acids and proteins used by students of higher education promoted their spatial perception of these molecules, allowing the prediction of intra- and intermolecular interactions. It is important to emphasize the importance of these educational resources in the construction of more functional mental models of cells and of intracellular processes.

  20. Fathers' Role as Attachment Figures: An Interview with Sir Richard Bowlby

    Science.gov (United States)

    Newland, Lisa A.; Coyl, Diana D.

    2010-01-01

    Sir Richard Bowlby, son of John Bowlby, has carried on his father's work by lecturing and writing on the topic of attachment theory. He has initiated and maintained international connections with researchers, practitioners and agencies in the field of child development, and has produced training videos to more widely disseminate information about…

  1. Bupivacaine Lozenge Compared with Lidocaine Spray as Topical Pharyngeal Anesthetic before Unsedated Upper Gastrointestinal Endoscopy

    DEFF Research Database (Denmark)

    Salale, Nesrin; Treldal, Charlotte; Mogensen, Stine

    2014-01-01

    Unsedated upper gastrointestinal endoscopy (UGE) can induce patient discomfort, mainly due to a strong gag reflex. The aim was to assess the effect of a bupivacaine lozenge as topical pharyngeal anesthetic compared with standard treatment with a lidocaine spray before UGE. Ninety-nine adult...... outpatients undergoing unsedated diagnostic UGE were randomized to receive either a bupivacaine lozenge (L-group, n = 51) or lidocaine spray (S-group, n = 42). Primary objective was assessment of patient discomfort including acceptance of the gag reflex during UGE. The L-group assessed the discomfort...... significantly lower on a visual analog scale compared with the S-group (P = 0.02). There was also a significant difference in the four-point scale assessment of the gag reflex (P = 0.03). It was evaluated as acceptable by 49% in the L-group compared with 31% in the S-group. A bupivacaine lozenge compared...

  2. Comprehensive evaluation of carboxylated nanodiamond as a topical drug delivery system.

    Science.gov (United States)

    Lim, Dae Gon; Kim, Ki Hyun; Kang, Eunah; Lim, Sun Hee; Ricci, Jeremy; Sung, Si Kwon; Kwon, Myoung Taek; Jeong, Seong Hoon

    2016-01-01

    The best strategy in the development of topical drug delivery systems may be to facilitate the permeation of drugs without any harmful effects, while staying on the skin surface and maintaining stability of the system. Nanodiamonds (NDs) play a key role with their excellent physicochemical properties, including high biocompatibility, physical adsorption, reactive oxygen species (ROS) scavenging capability, and photostabilizing activity. Z-average sizes of carboxylated ND (ND-COOH) agglutinate decreased significantly as the pH increased. Fluorescein-conjugated ND was observed only on the stratum corneum, and no sample diffused into the dermal layer even after 48 hours. Moreover, ND-COOH and ND-COOH/eugenol complex did not show significant toxic effects on murine macrophage cells. ND improved in vitro skin permeation >50% acting as a "drug reservoir" to maintain a high drug concentration in the donor chamber, which was supported by quartz crystal microbalance results. Moreover, ND-COOH could adsorb a drug amount equivalent to 80% of its own weight. A photostability study showed that ND-COOH increased the photostability ~47% with regard to rate constant of the eugenol itself. A significant decrease in ROS was observed in the ND-COOH and ND-COOH/eugenol complex compared with the negative control during intracellular ROS assay. Moreover, ROS and cupric reducing antioxidant capacity evaluation showed that ND-COOH had synergistic effects of antioxidation with eugenol. Therefore, ND-COOH could be used as an excellent topical drug delivery system with improved permeability, higher stability, and minimized safety issue.

  3. Gaining trust as well as respect in communicating to motivated audiences about science topics.

    Science.gov (United States)

    Fiske, Susan T; Dupree, Cydney

    2014-09-16

    Expertise is a prerequisite for communicator credibility, entailing the knowledge and ability to be accurate. Trust also is essential to communicator credibility. Audiences view trustworthiness as the motivation to be truthful. Identifying whom to trust follows systematic principles. People decide quickly another's apparent intent: Who is friend or foe, on their side or not, or a cooperator or competitor. Those seemingly on their side are deemed warm (friendly, trustworthy). People then decide whether the other is competent to enact those intents. Perception of scientists, like other social perceptions, involves inferring both their apparent intent (warmth) and capability (competence). To illustrate, we polled adults online about typical American jobs, rated as American society views them, on warmth and competence dimensions, as well as relevant emotions. Ambivalently perceived high-competence but low-warmth, "envied" professions included lawyers, chief executive officers, engineers, accountants, scientists, and researchers. Being seen as competent but cold might not seem problematic until one recalls that communicator credibility requires not just status and expertise but also trustworthiness (warmth). Other research indicates the risk from being enviable. Turning to a case study of scientific communication, another online sample of adults described public attitudes toward climate scientists specifically. Although distrust is low, the apparent motive to gain research money is distrusted. The literature on climate science communicators agrees that the public trusts impartiality, not persuasive agendas. Overall, communicator credibility needs to address both expertise and trustworthiness. Scientists have earned audiences' respect, but not necessarily their trust. Discussing, teaching, and sharing information can earn trust to show scientists' trustworthy intentions.

  4. Evolution of food antioxidants as a core topic of food science for a century.

    Science.gov (United States)

    Cömert, Ezgi Doğan; Gökmen, Vural

    2018-03-01

    Antioxidants are among the most studied topics both in the area of food science and nutrition. Antioxidants were firstly used as just a food preservative, then it was realized that they inhibited the oxidation processes not only in foods but also in human metabolism. Then, they gained the spotlight with their important roles both in foods and in human body. Consequently, significant number of research articles focusing on the antioxidant content of different foods, analytical methods for better estimation and measurement of the antioxidant capacity of foods have been publishing for years. In addition, there is a growing interest among the food scientists in improving the knowledge on the physiological effects of antioxidants in the human body. This review provides a historical overview about antioxidants covering their occurrence and roles in various foods, analytical methods for the determination of their antioxidant capacity, and their physiological effects. Copyright © 2017 Elsevier Ltd. All rights reserved.

  5. Design and evaluation of novel topical formulation with olive oil as natural functional active.

    Science.gov (United States)

    Mota, Ana Henriques; Silva, Catarina Oliveira; Nicolai, Marisa; Baby, André; Palma, Lídia; Rijo, Patrícia; Ascensão, Lia; Reis, Catarina Pinto

    2017-07-03

    Currently, the innovative skin research is focused on the development of novel topical formulations loaded with natural functional actives. The health benefits of olive oil are unsurpassed and many others are revealed as research studies allow the understanding of its unlimited properties. Olive oil has a protective toning effect on skin, but it is not transported effectively into its layers. Aiming the development of a cosmetic formulation for skin photoprotection and hydration, we have prepared and characterized macro-sized particles, made of a hydrogel polymer, loaded with olive oil. Alginate beads were uniform in shape, with minimal oil leakage, offering interesting prospects for encapsulation of lipophilic and poorly stable molecules, like olive oil. In vitro photoprotection and in vivo tolerance tests were in favor of this application. Thus, this study suggests that the incorporation of the olive oil-loaded particles into a cream formulation provides strong moisturizing properties and a photoprotective potential, when applied to healthy subjects.

  6. INTERVIEWING EXPATRIATES AS A SOURCE FOR STUDENTS IN UNDERSTANDING DIFFERENCES IN CULTURAL BACKGROUNDS

    Directory of Open Access Journals (Sweden)

    Ni Luh Putu Sri Adnyani,S.Pd.,M.Hum.

    2017-04-01

    Full Text Available Interviewing expatriates whom live in Bali was one of the projects that have been done in Cross Cultural Understanding class in the academic year of 2011/2012. The aims of the project was 1 students have direct communication with foreigners living in Bali, 2 students obtain information related to cultural differences experienced by expatriates and 3 students find out how the expatriates overcome cultural differences. The project was done by the students in six weeks. Each student had to contact an expatriate who can easily be found in Bali. They had to prepare an interview guide and put the result of their interview on paper. Each student had to present the result of their project to the class continued with classroom discussion. At the end of the presentation, the students conclude differences in cultural aspects experienced by the expatriates and how they handled those differences to be able to live in Bali. By interviewing expatriates, students had direct information about differences in cultural backgrounds and made Cross Cultural Understanding subject becomes a more realistic issue.

  7. The Role of Web Interviews as Part of a National Travel Survey

    DEFF Research Database (Denmark)

    Christensen, Linda

    2013-01-01

    — The analyses show that web interviews are saving money, even though a more intensive post-processing is necessary. The analyses seem to show that the CAWI is resulting in a more careful answering which results in more trips reported. A CAWI is increasing the participation of children in the survey...

  8. Interviews as a Selection Tool for Entry-Level Hospitality Employees.

    Science.gov (United States)

    Martin, Lynda

    2002-01-01

    Responses from human resource professionals in restaurants (n=85) and hotels (n=118) identified critical entry-level job behaviors that might be used in developing behavior-based interviews. The large variety of responses and lack of agreement suggest that clear identification of these behaviors may be an area of weakness in the hospitality…

  9. Time as a Key Topic in Health Professionals’ Perceptions of Clinical Handovers

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    Bernadette M. Watson

    2014-10-01

    Full Text Available Clinical handovers are an essential part of the daily care and treatment of hospital patients. We invoked a language and social psychology lens to investigate how different health professional groups discussed the communication problems and strengths they experienced in handovers. We conducted in-depth interviews with three different health professional groups within a large metropolitan hospital. We used Leximancer text analytics software as a tool to analyze the data. Results showed that time was of concern to all groups in both similar and diverse ways. All professionals discussed time management, time pressures, and the difficulties of coordinating different handovers. Each professional group had its own unique perceptions and priorities about handovers. Our findings indicated that health professionals understood what was required for handover improvement but did not have the extra capacity to alter their current environment. Hospital management, with clinicians, need to implement handover schedule processes that prioritize interprofessional representation.

  10. Propolis as lipid bioactive nano-carrier for topical nasal drug delivery.

    Science.gov (United States)

    Rassu, Giovanna; Cossu, Massimo; Langasco, Rita; Carta, Antonio; Cavalli, Roberta; Giunchedi, Paolo; Gavini, Elisabetta

    2015-12-01

    Propolis shows therapeutic properties ascribed to the presence of some flavonoids, phenolic acids, and their esters; it is a natural multifunctional material, solid at room temperature, and composed mainly of resin and waxes. We therefore used propolis as a lipid material to prepare solid lipid nanoparticles (SLNs); SLNs are proposed bioactive medications for topical intranasal therapy. Suitable formulation parameters were studied and the SLNs obtained by the high shear homogenization method were characterized; a selected formulation was viscosized to increase the residence time. Dimensional, morphological, and solid-state characterizations of the formulated SLNs were performed. In vitro and ex vivo permeation tests of diclofenac sodium, the model drug, and polyphenols were carried out. The propolis amount and surfactant concentration represent the key parameters that affect nanoparticle properties in terms of size, drug and polyphenol content, and physical stability. Size dispersions of about 600 nm and 0.4 PI were obtained, which do not change by increasing the viscosity. Drug is encapsulated in SLNs, as demonstrated by FTIR and DSC analyses. In vitro and ex vivo studies prove that drug and polyphenols do not cross the membranes; therefore, propolis-based SLNs could be used as delivery systems of diclofenac and flavonoids for the local treatment of nasal cavity diseases. Due to propolis composition, the proposed formulation could be used as a bioactive medication in which the carrier can exert a complementary effect with the loaded drug. Copyright © 2015 Elsevier B.V. All rights reserved.

  11. Preparing and conducting interviews to collect data.

    Science.gov (United States)

    Doody, Owen; Noonan, Maria

    2013-05-01

    To describe three styles of interviews and discuss issues regarding planning and conducting interviews. Interviews are probably the approach most used to collect data in studies. They are particularly useful in uncovering the story behind a participant's experiences. Researchers can follow a line of questions to gain information about a topic, or further explore responses or findings. But the researcher needs to plan and decide the format of the interview before collecting data. The authors included papers on structured, unstructured and semi-structured interviews published in a peer-reviewed joumrnal and in English. Interviews are one of the most common metods of data collection in qualitative research. However they require the researcher to have a sound understanding of their use and appropriateness. The ability to conduct interviews is one that develops over time and to aid the researcher in developing their interview skills they should consult with other researchers, seeking comments and advice and, critically, to appraise audio recordings. This article aims to support students who are undertaking research modules as part of their academic studies, writing a research proposal or novice researchers who are about to use interviews as a means of data collection. To conduct a successful interview, researchers need to develop their interview technique, choose the right method and carefully plan for all aspects of the process.

  12. Topical issues of functioning a region as a social-economic system

    Directory of Open Access Journals (Sweden)

    Roman Andreyevich Timofeyev

    2015-09-01

    Full Text Available Objective to identify the topical issues of forming a region as a socialeconomic system. Methods systematic approach based on general scientific methods of empirical and theoretical research such as observation and comparison analysis and synthesis induction and deduction as well as comparativehistorical method statistical methods macroeconomic analysis. Results the major issues of applying a systematic approach to the analysis of the region as a socioeconomic system were explored and analyzed. The authors proved the most important features of the system considered different points of view on the content of the region as a system category analyzed the basic paradigm of the region functioning identified specific properties inherent to the region as a system conducted analysis of the modern Russian and foreign literature which showed that at present there is no consensus about the structural content of the region as an economic system at mesolevel suggested the authorsrsquo definition of the region category conclusions were made about the applicability of systematic approach to analyzing a region as a socioeconomic system. Scientific novelty the trends and problems of the region formation as an economic system were specifiedin the form of components of a single social and economic system the conceptual scheme for the region development as a socioeconomic system at mesolevel was proposed the author39s definition of the regionwas given. The suggested conceptual framework focuses on regional subsystems each of which is characterized by resources capacity the effective use of which is intended to ensure the sustainable and competitive territory development while increasing the quality of life of the population under federalism and globalization. Practical significance conclusions and suggestions can be used by public authorities in the strategic policy development for the effective management of the Russian regions. nbsp

  13. Routine history as compared to audio computer-assisted self-interview for prenatal care history taking.

    Science.gov (United States)

    Mears, Molly; Coonrod, Dean V; Bay, R Curtis; Mills, Terry E; Watkins, Michelle C

    2005-09-01

    To compare endorsement rates obtained with audio computer-assisted self-interview versus routine prenatal history. A crosssectional study compared items captured with the routine history to those captured with a computer interview (computer screen displaying and computer audio reading questions, with responses entered by touch screen). The subjects were women (n=174) presenting to a public hospital clinic for prenatal care. The prevalence of positive responses using the computer interview was significantly greater (p history for induced abortion (16.8% versus 4.0%), lifetime smoking (12.8% versus 5.2%), intimate partner violence (10.0% versus 2.4%), ectopic pregnancy (5.2% versus 1.1%) and family history of mental retardation (6.7% versus 0.6%). Significant differences were not found for history of spontaneous abortion, hypertension, epilepsy, thyroid disease, smoking during pregnancy, gynecologic surgery, abnormal Pap test, neural tube defect or cystic fibrosis family history. However, in all cases, prevalence was equal or greater with the computer interview. Women were more likely to report sensitive and high-risk behavior, such as smoking history, intimate partner violence and elective abortion, with the computer interview. The computer interview displayed equal or increased patient reporting of positive responses and may therefore be an accurate method of obtaining an initial history.

  14. Comprehensive evaluation of carboxylated nanodiamond as a topical drug delivery system

    Directory of Open Access Journals (Sweden)

    Lim DG

    2016-05-01

    Full Text Available Dae Gon Lim,1,* Ki Hyun Kim,1,* Eunah Kang,2 Sun Hee Lim,3 Jeremy Ricci,3 Si Kwon Sung,3 Myoung Taek Kwon,3 Seong Hoon Jeong1 1College of Pharmacy, Dongguk University-Seoul, Gyeonggi, 2School of Chemical Engineering and Material Science, Chung-Ang University, 3NanoResource Co. Ltd., Seoul, Republic of Korea *These authors contributed equally to this work Abstract: The best strategy in the development of topical drug delivery systems may be to facilitate the permeation of drugs without any harmful effects, while staying on the skin surface and maintaining stability of the system. Nanodiamonds (NDs play a key role with their excellent physicochemical properties, including high biocompatibility, physical adsorption, reactive oxygen species (ROS scavenging capability, and photostabilizing activity. Z-average sizes of carboxylated ND (ND–COOH agglutinate decreased significantly as the pH increased. Fluorescein-conjugated ND was observed only on the stratum corneum, and no sample diffused into the dermal layer even after 48 hours. Moreover, ND–COOH and ND–COOH/eugenol complex did not show significant toxic effects on murine macrophage cells. ND improved in vitro skin permeation >50% acting as a “drug reservoir” to maintain a high drug concentration in the donor chamber, which was supported by quartz crystal microbalance results. Moreover, ND–COOH could adsorb a drug amount equivalent to 80% of its own weight. A photostability study showed that ND–COOH increased the photostability ~47% with regard to rate constant of the eugenol itself. A significant decrease in ROS was observed in the ND–COOH and ND–COOH/eugenol complex compared with the negative control during intracellular ROS assay. Moreover, ROS and cupric reducing antioxidant capacity evaluation showed that ND–COOH had synergistic effects of antioxidation with eugenol. Therefore, ND–COOH could be used as an excellent topical drug delivery system with improved permeability

  15. Evaluation of Honey as a Topical Therapy for Intraoral Wound Healing in Rats.

    Science.gov (United States)

    Chamani, Goli; Zarei, Mohammad Reza; Mehrabani, Mitra; Mehdavinezhad, Ali; Vahabian, Mehrangiz; Ahmadi-Motamayel, Fatemah

    2017-03-01

    Honey is one of the oldest known medicines. Its medical and therapeutic importance has been recently rediscovered. Honey is an effective treatment for infected wounds and ulcers. The aim of this study was to determine the effect of honey as a topical therapy for intraoral wound healing in rats. Thirty-two male rats were divided into experimental and control groups (consisting of 16 rats, 4 animals in each group). A 2-mm mucosal defect was made to the depth of the periosteum using punch biopsy. Honey was applied to the wound every day, and the ulcer size was measured daily. On days 2, 4, 6, and 8, four rats were euthanized from each group (experimental and control groups), and tissues were histopathologically evaluated. Healing processes were studied as follows: the size of ulcer, inflammatory response, reepithelialization, and granulation tissue formation. The mean rank of wound size was significantly reduced in the honey group (2.50), as compared to the control group (6.50). Reepithelialization and granulation tissue formation mean rank were significantly higher in the honey group (6.50) than in the control group (2.50). Inflammation mean rank was statistically lower in the honey group (2.63) compared with the control group (6.38). Honey was shown to have a beneficial effect on the healing of oral ulcers in rats in this model. Further research may shed light on the effects of honey on different types of ulcers in humans.

  16. Narrative interviewing.

    Science.gov (United States)

    Anderson, Claire; Kirkpatrick, Susan

    2016-06-01

    Introduction Narrative interviews place the people being interviewed at the heart of a research study. They are a means of collecting people's own stories about their experiences of health and illness. Narrative interviews can help researchers to better understand people's experiences and behaviours. Narratives may come closer to representing the context and integrity of people's lives than more quantitative means of research. Methodology Researchers using narrative interview techniques do not set out with a fixed agenda, rather they tend to let the interviewee control the direction, content and pace of the interview. The paper describes the interview process and the suggested approach to analysis of narrative interviews, We draw on the example from a study that used series of narrative interviews about people's experiences of taking antidepressants. Limitations Some people may find it particularly challenging to tell their story to a researcher in this way rather than be asked a series of questions like in a television or radio interview. Narrative research like all qualitative research does not set out to be generalisable and may only involve a small set of interviews.

  17. Ferulic Acid-Based Polymers with Glycol Functionality as a Versatile Platform for Topical Applications.

    Science.gov (United States)

    Ouimet, Michelle A; Faig, Jonathan J; Yu, Weiling; Uhrich, Kathryn E

    2015-09-14

    Ferulic acid-based polymers with aliphatic linkages have been previously synthesized via solution polymerization methods, yet they feature relatively slow ferulic acid release rates (∼11 months to 100% completion). To achieve a more rapid release rate as required in skin care formulations, ferulic acid-based polymers with ethylene glycol linkers were prepared to increase hydrophilicity and, in turn, increase ferulic acid release rates. The polymers were characterized using nuclear magnetic resonance and Fourier transform infrared spectroscopies to confirm chemical composition. The molecular weights, thermal properties (e.g., glass transition temperature), and contact angles were also obtained and the polymers compared. Polymer glass transition temperature was observed to decrease with increasing linker molecule length, whereas increasing oxygen content decreased polymer contact angle. The polymers' chemical structures and physical properties were shown to influence ferulic acid release rates and antioxidant activity. In all polymers, ferulic acid release was achieved with no bioactive decomposition. These polymers demonstrate the ability to strategically release ferulic acid at rates and concentrations relevant for topical applications such as skin care products.

  18. Interview with Clive Phillpot

    Directory of Open Access Journals (Sweden)

    David Maroto

    2017-06-01

    Full Text Available Clive Phillpot is an English curator, writer, and librarian. Between 1977 and 1994 he was the Director of the Library at the Museum of Modern Art (MoMA in New York, where he founded and curated the Artist Book´s Collection. Previously, he was the librarian at the Chelsea School of Art in London. He has written and edited numerous articles and books on the topic of the artist’s book, whose concept he decisively contributed to define. In the 1960s and 1970s the artist’s book emerged as an accessible art medium by being cheap, portable, and mass distributed. In this interview I try to learn whether those expectations have survived, updated and transformed in the contemporary phenomenon of the artist’s novel.

  19. Efficacy of topical and systemic itraconazole as a broad-spectrum antifungal agent in mycotic corneal ulcer. A preliminary study

    Directory of Open Access Journals (Sweden)

    Agarwal Pankaj

    2001-01-01

    Full Text Available Purpose: To evaluate the efficacy of topical (1% and systemic itraconazole against common fungi such as Aspergillus and other filamentous fungi that cause mycotic corneal ulcer. Methods: A prospective randomised, controlled study was done in 54 clinically suspected cases of fungal keratitis of which 44 were culture proven. Half the cases (n=27 with superficial involvement were treated with only topical itraconazole (1% and the other half were treated with both topical and systemic itraconazole. Results:Aspergillus, Penicillium and Fusarium were the most common fungi isolated. The ulcer resolved in 42 eyes (77% and 12 eyes (23% did not respond well to treatment. Four of 12 non-responding eyes were caused by Fusarium species. Conclusion: Itraconazole, given either topically or systemically, is effective in treating mycotic corneal ulcers.

  20. The effect of diethylene glycol monoethyl ether as a vehicle for topical delivery of ivermectin.

    Science.gov (United States)

    Yazdanian, M; Chen, E

    1995-01-01

    The effect of diethylene glycol monoethyl ether (DGME; Transcutol) on the permeation of ivermectin, a broad-spectrum antiparasitic agent, through bovine skin was evaluated by in vitro permeation experiments followed by serial sectioning of the skin to assess the amount of ivermectin retained in the skin. Ivermectin permeation through bovine skin was enhanced by DGME and this enhancement was DGME-concentration-dependent. Permeation of ivermectin was effectively enhanced in vehicles with low proportions of DGME, but the magnitude of permeation enhancement decreased as the proportion of DGME increased. The permeation was accompanied by the formation of cutaneous depots of ivermectin. Furthermore, the data indicated that the flux and the cutaneous accumulation of ivermectin were sensitive to the concentration gradient of DGME across the skin. This suggested that ivermectin was permeating with DGME, in which it is very soluble. Hence, the enhancing mechanism involves solubilization of the ivermectin by DGME and the transport of DGME itself across the skin. Based on these results, DGME appears to be a potential vehicle for topical delivery of ivermectin by transport through the skin and through formation of cutaneous depots of ivermectin.

  1. Motivational interviewing as an instrument to promote physical activity and dietary adherence among people with diabetes: literature review

    Directory of Open Access Journals (Sweden)

    Juan Manuel Leyva-Moral

    2007-07-01

    Full Text Available Motivational Interviewing is a technique which is used to get behaviour changes and whose efficacy has been highly proved in areas such as smoking cessation or alcoholism.This review pretends to ascertain if Motivational Interviewing is the most effective strategy to increase adherence to physical activity and dietary modification programs among people with type 2 diabetes.Method: An exhaustive scientific national and international literature review was done. The following electronic databases were used: PsychoINFO, PubMed, OVID Full Text, CINAHL, CUIDEN, IBECS, CompluDoc y ENFISPO. The search strategy was limited to articles published between 1995 and 2005.Results: Eleven studies were included. Motivational Interviewing appears as a useful technique to increase adherence to physical activity and diet programs in people with type 2 diabetes. However, an in-depth analysis of the studies included in this literature review shows important methodological flows which could have caused some bias. The author affirms that Motivational Interviewing is just a useful technique but no more useful as other behavioural techniques used nowadays. There are not enough strong scientific evidences to assure the standardization of Motivational Interviewing in the field of diabetic education.

  2. Topical anesthesia

    Science.gov (United States)

    Kumar, Mritunjay; Chawla, Rajiv; Goyal, Manish

    2015-01-01

    Topical anesthetics are being widely used in numerous medical and surgical sub-specialties such as anesthesia, ophthalmology, otorhinolaryngology, dentistry, urology, and aesthetic surgery. They cause superficial loss of pain sensation after direct application. Their delivery and effectiveness can be enhanced by using free bases; by increasing the drug concentration, lowering the melting point; by using physical and chemical permeation enhancers and lipid delivery vesicles. Various topical anesthetic agents available for use are eutectic mixture of local anesthetics, ELA-max, lidocaine, epinephrine, tetracaine, bupivanor, 4% tetracaine, benzocaine, proparacaine, Betacaine-LA, topicaine, lidoderm, S-caine patch™ and local anesthetic peel. While using them, careful attention must be paid to their pharmacology, area and duration of application, age and weight of the patients and possible side-effects. PMID:26702198

  3. Topical anesthesia

    Directory of Open Access Journals (Sweden)

    Mritunjay Kumar

    2015-01-01

    Full Text Available Topical anesthetics are being widely used in numerous medical and surgical sub-specialties such as anesthesia, ophthalmology, otorhinolaryngology, dentistry, urology, and aesthetic surgery. They cause superficial loss of pain sensation after direct application. Their delivery and effectiveness can be enhanced by using free bases; by increasing the drug concentration, lowering the melting point; by using physical and chemical permeation enhancers and lipid delivery vesicles. Various topical anesthetic agents available for use are eutectic mixture of local anesthetics, ELA-max, lidocaine, epinephrine, tetracaine, bupivanor, 4% tetracaine, benzocaine, proparacaine, Betacaine-LA, topicaine, lidoderm, S-caine patch™ and local anesthetic peel. While using them, careful attention must be paid to their pharmacology, area and duration of application, age and weight of the patients and possible side-effects.

  4. An Interview with Lawrence M. Lieberman.

    Science.gov (United States)

    Academic Therapy, 1986

    1986-01-01

    An interview with L. Lieberman, a teacher educator and author, touches on such topics as departmentalization at the secondary and elementary level, the use of triple level tests to allow students to stay in mainstreamed settings, and the importance of emphasizing skill development rather than subject matter instruction in secondary resource rooms.…

  5. Is a motivational interviewing based lifestyle intervention for obese pregnant women across Europe implemented as planned?

    DEFF Research Database (Denmark)

    Jelsma, Judith G M; Simmons, David; Gobat, Nina

    2017-01-01

    mass index ≥29 kg/m(2). The intervention includes guidance on physical activity and/or healthy eating by a lifestyle coach trained in motivational interviewing (MI). The aim of this study was to assess the process elements: reach, dose delivered, fidelity and satisfaction and to investigate whether......BACKGROUND: Process evaluation is an essential part of designing and assessing complex interventions. The vitamin D and lifestyle intervention study (DALI) study is testing different strategies to prevent development of gestational diabetes mellitus among European obese pregnant women with a body....... Fidelity of eight (out of twelve) lifestyle coach practitioners was assessed by analysing audio recorded counselling sessions using the MI treatment integrity scale. Furthermore, associations between process elements and GWG were assessed with linear regression analyses. RESULTS: A total of 20...

  6. Motivational interviewing as a mechanism for change in men who batter: a randomized controlled trial.

    Science.gov (United States)

    Kistenmacher, Barbara R; Weiss, Robert L

    2008-01-01

    The present study reports on the potential effectiveness of motivational interviewing (MI) in changing the way batterers think about their violent behavior. Thirty-three domestic violence offenders who were court-mandated to treatment were randomly assigned to MI or a control condition before attending their first mandated treatment group. Consistent with predictions, the MI group demonstrated generally more improvement on stages of change subscales than the control group. Further, the MI group demonstrated a significantly greater decrease in the extent to which they blamed their violence on external factors. Current data indicate that MI has the potential to increase batterers' motivation to change, although validation trials with larger sample sizes and more refined measures are required.

  7. TOPICAL CASUAL TALKS AS RESPONSIVE LISTENING AND SPEAKING PERFORMANCES OF BEGINNERS

    Directory of Open Access Journals (Sweden)

    Taranindya Zulhi Amalia

    2017-04-01

    Full Text Available Global communication concern brings human to be familiar with English as early as possible. Nowadays beginner students started English orally in elementary school even kindergarten. At this moment, they dealth with listening and speaking skills and put them into practice. When they came down to English, some beginners feel uncomfortable in their learning because of facing formal situation. The beginners who were typically keen on playing and having fun comfortably could not be treated in teaching-learning that was usually presented to intermediate level or adult. Teachers had to create informal situation so that they were more relaxed and got chemistry one another. Dealing with comfortable zone put into informal situation in listening and speaking practices for the beginners, this study focused on topical casual talks. It set up a relaxed spot in order to explore effective communication related to their subject matters. The teachers/tutors could apply one of classroom listening and speaking performance types, responsive. This study used qualitative approach. While it refered to library research. The primary source was Elementary School Silabus. Whereas the secondary data sources were English teaching-learning books. This issue discussed about listening and speaking skills for beginners. The beginners classified into age 6-8. In listening section, the students processed teacher talk instantly. Afterwards in speaking, suitable direct short response answered the teacher talk. This action could be assessed by subjective test in the form of wh-questions and short answers test. Ultimately, the next comparable studies may converse different competences and performances for beginners or any levels.

  8. eHealth Technologies as an intervention to improve adherence to topical antipsoriatics: a systematic review.

    Science.gov (United States)

    Svendsen, Mathias Tiedemann; Andersen, Flemming; Andersen, Klaus Ejner

    2018-03-01

    Topical antipsoriatics are recommended first-line treatment of psoriasis, but rates of adherence are low. Patient support by use of electronic health (eHealth) services is suggested to improve medical adherence. To review randomised controlled trials (RCTs) testing eHealth interventions designed to improve adherence to topical antipsoriatics and to review applications for smartphones (apps) incorporating the word psoriasis. Literature review: Medline, Embase, Cochrane, PsycINFO and Web of Science were searched using search terms for eHealth, psoriasis and topical antipsoriatics. General analysis of apps: The operating systems (OS) for smartphones, iOS, Google Play, Microsoft Store, Symbian OS and Blackberry OS were searched for apps containing the word psoriasis. Literature review: Only one RCT was included, reporting on psoriasis patients' Internet reporting their status of psoriasis over a 12-month period. The rate of adherence was measured by Medication Event Monitoring System (MEMS ® ). An improvement in medical adherence and reduction of severity of psoriasis were reported. General analysis of apps: A total 184 apps contained the word psoriasis. There is a critical need for high-quality RCTs testing if the ubiquitous eHealth technologies, for example, some of the numerous apps, can improve psoriasis patients' rates of adherence to topical antipsoriatics.

  9. IT0: Discrete Math and Programming Logic Topics as a Hybrid Alternative to CS0

    Science.gov (United States)

    Martin, Nancy L.

    2015-01-01

    This paper describes the development of a hybrid introductory course for students in their first or second year of an information systems technologies degree program at a large Midwestern university. The course combines topics from discrete mathematics and programming logic and design, a unique twist on most introductory courses. The objective of…

  10. Severe Tinea corporis resulting from the use of topical steroids as ...

    African Journals Online (AJOL)

    Use of systemic and topical steroids is associated with many side effects. Cutaneous side effects of steroid include with many others susceptibility to cutaneous infections. One of such infections is Tinea corporis. Steroids form an important component of skin lightening and toning creams. Among females in our society the ...

  11. In vitro analysis of polyurethane foam as a topical hemostatic agent

    NARCIS (Netherlands)

    Broekema, Ferdinand I.; van Oeveren, Wim; Zuidema, Johan; Visscher, Susan H.; Bos, Rudolf R. M.

    Topical hemostatic agents can be used to treat problematic bleedings in patients who undergo surgery. Widely used are the collagen- and gelatin-based hemostats. This study aimed to develop a fully synthetic, biodegradable hemostatic agent to avoid exposure to animal antigens. In this in vitro study

  12. Recalling sexual behavior: a methodological analysis of memory recall bias via interview using the diary as the gold standard.

    Science.gov (United States)

    Graham, Cynthia A; Catania, Joseph A; Brand, Richard; Duong, Tu; Canchola, Jesse A

    2003-11-01

    This study examined the effect of time lag on the validity of retrospective self-reports of sexual behavior. Seventy-five heterosexual students (44 women, 31 men) made daily recordings of sexual behavior, condom use, and alcohol or substance use for 1 month. Ability of respondents to recall sexual behavior recorded during this period was assessed at 1, 2, and 3 months after diary completion using recall interviews (25 interviewed at each interval). For vaginal intercourse, total recall error was significantly greater at 3 months than at 1 month post-diary. For all other variables assessed, the 2- and 3-month time intervals did not produce significant increase in total recall error. Higher frequency of vaginal intercourse, orgasm, and alcohol use prior to sexual activity were associated with total recall error for some but not all behaviors and outcomes. The results provide a partial validation of the diary-interview recall model as a method for studying recall error.

  13. Four Decades of JDE Interviews: a Historical Content Analysis

    Science.gov (United States)

    Stahl, Norman A.; Theriault, Jennifer C.; Armstrong, Sonya L.

    2016-01-01

    This content analysis examines the topics, trends, and issues impacting developmental education and its professionals as evaluated by interviews that have appeared in the "Journal of Developmental Education" ("JDE") between the issuance of Volume 1 through Volume 39. A total of 76 interviews were analyzed with attention to…

  14. Tavaborole Topical

    Science.gov (United States)

    Tavaborole topical solution is used to treat fungal toenail infections (infections that may cause nail discoloration, splitting, or pain). Tavaborole topical solution is in a class of medications called antifungals. It works by stopping the growth of nail ...

  15. Efinaconazole Topical

    Science.gov (United States)

    Efinaconazole topical solution is used to treat fungal toenail infections (infections that may cause nail discoloration, splitting, or pain). Efinaconazole topical solution is in a class of medications called antifungals. It works by stopping the growth of nail ...

  16. Health Topics

    Science.gov (United States)

    ... Carpal tunnel syndrome Depression Irritable bowel syndrome Migraine Thyroid disease Urinary tract infections All A-Z health topics ... Carpal tunnel syndrome Depression Irritable bowel syndrome Migraine Thyroid disease Urinary tract infections All A-Z health topics ...

  17. Using Concept Mapping to Enhance the Research Interview

    Directory of Open Access Journals (Sweden)

    Ian M. Kinchin BSc, MPhil, PhD, CBiol, FSB.

    2010-03-01

    Full Text Available In this paper the authors report the use of concept mapping as a means of summarizing interview transcripts in the study of the information-seeking behavior of employees in an organization. Concept mapping differs from traditional methods of textual coding for interview analysis by making underlying cognitive structures transparent and giving a focus to the sets of propositions by which individuals construct meaning. Concept map structure correlates with the perceived richness of interview data. They provide quick summaries of the interview quality and may help to identify topics for further probing to elicit new information. In this study rich interviews provide complex concept map structures, whereas less successful interviews provide simpler, spoke structures. Issues in using concept maps with research interviews are discussed, including use as a retrospective interview probe, as a check on evidence saturation, as a form of data display or as a form of creative coding.

  18. Online stroke forum as source of data for qualitative research: insights from a comparison with patients' interviews.

    Science.gov (United States)

    Jamison, James; Sutton, Stephen; Mant, Jonathan; De Simoni, Anna

    2018-03-30

    To determine the appropriateness of an online forum compared with face-to-face interviews as a source of data for qualitative research on adherence to secondary prevention medications after stroke. A comparison of attributes of two data sources, interviews and a forum, using realistic evaluation; a comparison of themes around adherence according to the Perceptions and Practicalities Approach (PAPA) framework. Interviews were conducted in UK GP practices in 2013 and 2014; online posts were written by UK stroke survivors and family members taking part in the online forum of the Stroke Association between 2004 and 2011. 42 interview participants: 28 stroke survivors (age range 61-92 years) and 14 caregivers (85% spouses). 84 online forum participants: 49 stroke survivors (age range 32-72 years) and 33 caregivers (60% sons/daughters). 10 attributes were identified within the two data sources and categorised under three domains (context, mechanisms and outcomes). Participants' characteristics of forum users were often missing. Most forum participants had experienced a stroke within the previous 12 months, while interviewees had done so 1-5 years previously.All interview themes could be matched with corresponding themes from the forum. The forum yielded three additional themes: influence of bad press on taking statins, criticisms of clinicians' prescribing practices and caregiver burden in assisting with medications and being advocates for survivors with healthcare professionals. An online forum is an appropriate source of data for qualitative research on patients' and caregivers' issues with adherence to secondary prevention stroke medications and may offer additional insights compared with interviews, which can be attributed to differences in the approach to data collection. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  19. eHealth Technologies as an Intervention to Improve Adherence to Topical Antipsoriatics

    DEFF Research Database (Denmark)

    Svendsen, Mathias Tiedemann; Andersen, Flemming; Andersen, Klaus Ejner

    2018-01-01

    BACKGROUND: Topical antipsoriatics are recommended first-line treatment of psoriasis, but rates of adherence are low. Patient support by use of electronic health (eHealth) services is suggested to improve medical adherence. OBJECTIVE: To review randomised controlled trials (RCTs) testing eHealth...... interventions designed to improve adherence to topical antipsoriatics and to review applications for smartphones (apps) incorporating the word psoriasis. MATERIAL AND METHODS: Literature review: Medline, Embase, Cochrane, PsycINFO, and Web of Science were searched using search terms for eHealth, psoriasis......' internet-reporting their status of psoriasis over a 12-month period. The rate of adherence was measured by Medication Event Monitoring System (MEMS®). An improvement in medical adherence and reduction of severity of psoriasis were reported. General analysis of apps: 184 apps contained the word psoriasis...

  20. Perspectives in Practice – Motivational interviewing as a component of a school-based obesity prevention program for adolescent girls

    Science.gov (United States)

    Friend, Sarah; Neumark-Sztainer, Dianne; Story, Mary

    2010-01-01

    Over the past decade, motivational interviewing has been used by health professionals to promote health behavior changes and help individuals increase their motivation or “readiness” to change. This paper describes a preliminary study used to evaluate the feasibility of motivational interviewing as a component in a school-based obesity prevention program, New Moves. New Moves is a program for inactive adolescent high school girls who are overweight or at risk for becoming overweight due to low levels of physical activity. Throughout the 18-week pilot study, 41 girls, aged 16–18 participated in an all-girls physical education class that focused on increasing physical activity, healthy eating and social support. Individual sessions, using motivational interviewing techniques, were also conducted with 20 of the girls to develop goals and actions related to eating and physical activity. Among the participants, 81% completed all seven of the individual sessions and girls set a goal 100% of the time. Motivational interviewing offers a promising approach as a component for school-based obesity prevention programs and was demonstrated to be feasible to implement in school settings and acceptable to the adolescents. PMID:19103327

  1. The human heart and the circulatory system as an interesting interdisciplinary topic in lessons of physics and biology

    International Nuclear Information System (INIS)

    Volná, M; Látal, F; Kubínek, R; Richterek, L

    2014-01-01

    Many topics which are closely related can be found in the national curriculum of the Czech Republic for physics and biology. One of them is the heart and the circulatory system in the human body. This topic was examined cross curriculum, a teaching module was created and the topic was chosen for our research. The task was to determine if the students of bachelor study are aware of connections between physics and biology within this topic and whether we can help them effectively to describe the corresponding physics phenomena in the human body connected, for example, with a heart attack or with the measurement of blood pressure. In this paper, the heart and the circulatory system are presented as suitable topics for an interdisciplinary teaching module which includes both theoretical and experimental parts. The module was evaluated by a group of first-year undergraduate students of physics at the Faculty of Science, Palacký University. The acquired knowledge was compared with another control group through a test. The highest efficiency of the module was evaluated on the basis of questions that covered the calculation problems. (paper)

  2. Interview Investigation of Insecure Attachment Styles as Mediators between Poor Childhood Care and Schizophrenia-Spectrum Phenomenology.

    Science.gov (United States)

    Sheinbaum, Tamara; Bifulco, Antonia; Ballespí, Sergi; Mitjavila, Mercè; Kwapil, Thomas R; Barrantes-Vidal, Neus

    2015-01-01

    Insecure attachment styles have received theoretical attention and some initial empirical support as mediators between childhood adverse experiences and psychotic phenomena; however, further specificity needs investigating. The present interview study aimed to examine (i) whether two forms of poor childhood care, namely parental antipathy and role reversal, were associated with subclinical positive and negative symptoms and schizophrenia-spectrum personality disorder (PD) traits, and (ii) whether such associations were mediated by specific insecure attachment styles. A total of 214 nonclinical young adults were interviewed for subclinical symptoms (Comprehensive Assessment of At-Risk Mental States), schizophrenia-spectrum PDs (Structured Clinical Interview for DSM-IV Axis II Disorders), poor childhood care (Childhood Experience of Care and Abuse Interview), and attachment style (Attachment Style Interview). Participants also completed the Beck Depression Inventory-II and all the analyses were conducted partialling out the effects of depressive symptoms. Both parental antipathy and role reversal were associated with subclinical positive symptoms and with paranoid and schizotypal PD traits. Role reversal was also associated with subclinical negative symptoms. Angry-dismissive attachment mediated associations between antipathy and subclinical positive symptoms and both angry-dismissive and enmeshed attachment mediated associations of antipathy with paranoid and schizotypal PD traits. Enmeshed attachment mediated associations of role reversal with paranoid and schizotypal PD traits. Attachment theory can inform lifespan models of how adverse developmental environments may increase the risk for psychosis. Insecure attachment provides a promising mechanism for understanding the development of schizophrenia-spectrum phenomenology and may offer a useful target for prophylactic intervention.

  3. Interview Investigation of Insecure Attachment Styles as Mediators between Poor Childhood Care and Schizophrenia-Spectrum Phenomenology

    Science.gov (United States)

    Sheinbaum, Tamara; Bifulco, Antonia; Ballespí, Sergi; Mitjavila, Mercè; Kwapil, Thomas R.; Barrantes-Vidal, Neus

    2015-01-01

    Background Insecure attachment styles have received theoretical attention and some initial empirical support as mediators between childhood adverse experiences and psychotic phenomena; however, further specificity needs investigating. The present interview study aimed to examine (i) whether two forms of poor childhood care, namely parental antipathy and role reversal, were associated with subclinical positive and negative symptoms and schizophrenia-spectrum personality disorder (PD) traits, and (ii) whether such associations were mediated by specific insecure attachment styles. Method A total of 214 nonclinical young adults were interviewed for subclinical symptoms (Comprehensive Assessment of At-Risk Mental States), schizophrenia-spectrum PDs (Structured Clinical Interview for DSM-IV Axis II Disorders), poor childhood care (Childhood Experience of Care and Abuse Interview), and attachment style (Attachment Style Interview). Participants also completed the Beck Depression Inventory-II and all the analyses were conducted partialling out the effects of depressive symptoms. Results Both parental antipathy and role reversal were associated with subclinical positive symptoms and with paranoid and schizotypal PD traits. Role reversal was also associated with subclinical negative symptoms. Angry-dismissive attachment mediated associations between antipathy and subclinical positive symptoms and both angry-dismissive and enmeshed attachment mediated associations of antipathy with paranoid and schizotypal PD traits. Enmeshed attachment mediated associations of role reversal with paranoid and schizotypal PD traits. Conclusions Attachment theory can inform lifespan models of how adverse developmental environments may increase the risk for psychosis. Insecure attachment provides a promising mechanism for understanding the development of schizophrenia-spectrum phenomenology and may offer a useful target for prophylactic intervention. PMID:26247601

  4. Interview Investigation of Insecure Attachment Styles as Mediators between Poor Childhood Care and Schizophrenia-Spectrum Phenomenology.

    Directory of Open Access Journals (Sweden)

    Tamara Sheinbaum

    Full Text Available Insecure attachment styles have received theoretical attention and some initial empirical support as mediators between childhood adverse experiences and psychotic phenomena; however, further specificity needs investigating. The present interview study aimed to examine (i whether two forms of poor childhood care, namely parental antipathy and role reversal, were associated with subclinical positive and negative symptoms and schizophrenia-spectrum personality disorder (PD traits, and (ii whether such associations were mediated by specific insecure attachment styles.A total of 214 nonclinical young adults were interviewed for subclinical symptoms (Comprehensive Assessment of At-Risk Mental States, schizophrenia-spectrum PDs (Structured Clinical Interview for DSM-IV Axis II Disorders, poor childhood care (Childhood Experience of Care and Abuse Interview, and attachment style (Attachment Style Interview. Participants also completed the Beck Depression Inventory-II and all the analyses were conducted partialling out the effects of depressive symptoms.Both parental antipathy and role reversal were associated with subclinical positive symptoms and with paranoid and schizotypal PD traits. Role reversal was also associated with subclinical negative symptoms. Angry-dismissive attachment mediated associations between antipathy and subclinical positive symptoms and both angry-dismissive and enmeshed attachment mediated associations of antipathy with paranoid and schizotypal PD traits. Enmeshed attachment mediated associations of role reversal with paranoid and schizotypal PD traits.Attachment theory can inform lifespan models of how adverse developmental environments may increase the risk for psychosis. Insecure attachment provides a promising mechanism for understanding the development of schizophrenia-spectrum phenomenology and may offer a useful target for prophylactic intervention.

  5. Severe hyperkalemia as a complication of timolol, a topically applied beta-adrenergic antagonist

    International Nuclear Information System (INIS)

    Swenson, E.R.

    1986-01-01

    Severe hyperkalemia occurred in a patient with radiation pneumonitis and glaucoma shortly after beginning prednisone therapy. There was no evidence of renal failure, diabetes, acidosis, increased potassium intake, or significant tissue trauma. Medications having adverse effects on potassium metabolism were considered, and the patient's use of timolol maleate eyedrops was discontinued. His serum potassium level normalized despite continuation of the prednisone therapy. He became hyperkalemic on rechallenge with timolol and normokalemic following its withdrawal. This case indicates that the potential for beta-blocker-induced hyperkalemia exists even with topical appreciation

  6. 'Just like the fact that I'm Syrian like you are Scottish': ascribing interviewer identities as a resource in cross-cultural interaction.

    Science.gov (United States)

    Widdicombe, Sue

    2015-06-01

    Interviews are used as a research tool in numerous studies of identity. They have also been studied as social interactions in themselves. From this perspective, analysts have looked at the ways interviews generate identities, and how both parties work to fulfill the associated roles and expectations (e.g., the interviewer's neutrality). Interviewers thus become a more 'visible' participant, and several studies examine the influence of their multiple category memberships on the interaction. This paper aims to extend these insights to the insider/outsider dilemma in interviews, by looking at how participants make relevant and use interviewer identities as a resource. The data comes from a corpus of interviews with Syrian people on identity conducted by a British interviewer. The analysis shows how the interviewer's identity as a sojourner and stranger was used to warrant positive assessments of national character; her national identity was invoked to normalize national feelings; her identity as Christian used to characterize religious identity as inherent; and her identity as Westerner was used to legitimate complaints. I discuss implications for interviews on identity and identity within interviews, and argue that this approach is a thoroughly empirical way to address the shifting, practical ascription of insider-outsider status to the interviewer. © 2014 The British Psychological Society.

  7. Motivational interviewing

    DEFF Research Database (Denmark)

    Karlsen, Kamilla; Humaidan, Peter; Sørensen, Lise H

    2013-01-01

    This is a retrospective study to investigate whether motivational interviewing increases weight loss among obese or overweight women prior to fertility treatment. Women with body mass index (BMI) > 30 kg/m(2) approaching the Fertility Clinic, Regional Hospital Skive, were given advice about diet...... in weight loss programs for obese and overweight women prior to fertility treatment....... and physical activity with the purpose of weight loss. In addition, they were asked if they wanted to receive motivational interviewing. Among other data, age, height and weight were obtained. Main outcomes were weight loss measured in kg and decrease in BMI. We studied 187 women: 110 received sessions...

  8. A Pilot Study of a Picture- and Audio-Assisted Self-Interviewing Method (PIASI) for the Study of Sensitive Questions on HIV in the Field

    Science.gov (United States)

    Aarnio, Pauliina; Kulmala, Teija

    2016-01-01

    Self-interview methods such as audio computer-assisted self-interviewing (ACASI) are used to improve the accuracy of interview data on sensitive topics in large trials. Small field studies on sensitive topics would benefit from methodological alternatives. In a study on male involvement in antenatal HIV testing in a largely illiterate population…

  9. Health professionals perceive teamwork with relatives as an obstacle in their daily work - a focus group interview

    DEFF Research Database (Denmark)

    Laursen, Jannie; Broholm, Malene; Rosenberg, Jacob

    2017-01-01

    of this teamwork. Methods: The study was descriptive and exploratory and had a qualitative design with a phenomenological/hermeneutic orientation for the interviews. Focus group was the chosen methodology. The study comprised 19 health professionals in four focus groups. Results: Two themes emerged from...... makes it difficult for them to integrate relatives more and see them as participants in a natural teamwork for the benefit of the patient....

  10. The Concept of the Interculture in Time: (Intercultural Topics in Textbooks of French as a Foreign Language

    Directory of Open Access Journals (Sweden)

    Meta Lah

    2012-12-01

    Full Text Available The article deals with the concept of interculturality as used in foreign language didactics. In accordance with the definition of interculturality given in the first part of the article, two categories are included in the analysis – two “levels” of culture, each of them bearing a different name in literature, namely high and popular culture. Various textbooks used for teaching French as a foreign language in Slovenia in both the past and present were chosen for the analysis of topics that cover a fairly long period of time – among them the textbooks by two Slovenian authors: Južnič (1938 and Grad (1954, as well as some generally-used French textbooks, such as Cours de langue et de civilisation françaises (1953, Le nouveau sans frontières (1988 and Nouveau rond point (2011. The article is based on the hypothesis that high culture is more likely to be present in the older textbooks, which are based on traditional methods, whereas in modern textbooks more popular, everyday topics can be found. It is also presumed that topics in modern textbooks are, compared to their more traditional counterparts, introduced in an intercultural manner which could encourage students to compare the culture of the foreign country with their own. Both hypotheses are partly confirmed. In Slovenian textbooks there are very few culture-based topics. On the other hand, they are present in all French textbooks, regardless of the methodology. It is true that Mauger introduces more high culture than the others and that the intercultural topics are presented only in the most recent textbook. In all the others, it is exclusively the culture of the target country that is introduced.

  11. [The social security system as a topic in medical education. Own experiences and description of student's contribution].

    Science.gov (United States)

    Seidel, H J; Schochat, T

    2001-07-01

    The special subject "sociomedicine", as defined for medical students in "items to which the written examination in the second part of the medical examination can relate" has been taught by this department for 25 years as part of the course on medical ecology. There are 4 lectures (structure of the health care system; preventive care by doctors in the community and at the place of work; introduction to health economy; introduction to epidemiology) and the following seminars in small groups: social security systems; health insurance; excursion to a rehabilitation hospital; health reporting; epidemiology. The topics are presented and taught with emphasis on didactically useful and local examples. To ensure student participation "personal data" were introduced: Students give short reports on topics presented to them or they have to formulate questions to the topic of the seminar, questions or subjects to be dealt with. The questions concerning "social security systems" and "health insurance", collected over a 6 year period, were analyzed. Initially, the subject "sociomedicine" is not much appreciated by the students. The analysis shows what students think when they are challenged. The spectrum of questions mainly reflects the discussion in the media: Finance and benefits predominate, also budget and misuse, especially with reference to old-age pension and health insurance. Questions related to specific medical functions as e. g. medical expert opinion, are less often raised. However, topics such as "expansion of preventive measures", "chip card and utilisation" and "unconventional methods" are often addressed. A special demand for personal advice is seen during small talk discussions in intermissions (health insurance). The topics "medical expert opinion" and "comparison of public and private health insurance" have become positive knowledge required for the examination and for practising the medical profession. With these subjects as a starting point it appears easier

  12. Motivational Interviewing as a Framework to Guide School-Based Coaching

    Science.gov (United States)

    Lee, Jon; Frey, Andy J.; Herman, Keith; Reinke, Wendy

    2014-01-01

    In school-based settings, coaching is described as a professional development practice in which a person with specialized knowledge works with a teacher to change current practices to better student outcomes. Coaching has emerged as a strategy to support the successful deployment of evidence-based interventions. Still, little is known about the…

  13. Plasma levels of triamcinolone acetonide as determined by radioimmunoassay after topical application

    International Nuclear Information System (INIS)

    In this paper a method for the radioimmunological determination of triamcinolone acetonide (TAAc) in plasma is described. The antiserum used in the radioimmunological determinations showed high specifity for TAAc; the minimal detectable amount was 0.2 ng. The course of the plasma concentrationtime curve of TAAc after intravenous injection into rats was analysed. The concentration of TAAc in the blood of the patients after topical application of the drug is very low. No detectable amount of TAAc was found in the blood of out-patients. Hospitalized patients treated with TAAc under plastic occlusion showed plasma levels ranging from 0.8 to 3.4 ng/ml. This level remained constant throughout the treatment. (orig.) 891 AJ [de

  14. Effect of topical anti-glaucoma medications on late pupillary light reflex, as evaluated by pupillometry

    DEFF Research Database (Denmark)

    Ba-Ali, Shakoor; Sander, Birgit; Brøndsted, Adam Elias

    2015-01-01

    PURPOSE: The late post-illumination pupillary response (PIPR 10-30s ) to blue light is reduced in glaucoma, suggesting that pupillometry can be used in clinical glaucoma evaluation. Since animal studies have indicated that common anti-glaucomatous agents affect the iris muscle, we investigated...... the short-term effect of the anti-glaucoma drugs on the pupillary light reflex and in particular on the PIPR10-30s. METHODS: In this randomized, double-masked, crossover trial, pupillometry was performed before and after topical administration of latanoprost, dorzolamide, and timolol in 20 healthy subjects...... reduced by all three drugs after 3.5 h (p glaucoma medications did not interfere with the blue light elicited PIPR. Dorzolamide reduced pupil size, while timolol reduced both pupil size and maximal contraction to red...

  15. Nanoemulsion as a carrier to improve the topical anti-inflammatory activity of stem bark extract of Rapanea ferruginea

    Science.gov (United States)

    Dal Mas, Juarana; Zermiani, Tailyn; Thiesen, Liliani C; Silveira, Joana LM; da Silva, Kathryn ABS; de Souza, Márcia M; Malheiros, Angela; Bresolin, Tania MB; Lucinda-Silva, Ruth M

    2016-01-01

    The aim of this study was to develop nanoemulsion containing soft extract of stem bark of Rapanea ferruginea to improve the topical delivery and anti-inflammatory activity. The extract of R. ferruginea stem bark was incorporated into the oily phase of the nanoemulsion by the method of phase inversion at low energy. The developed nanoemulsion had an average droplet size of 47.88±8.20 nm and a polydispersibility index of 0.228. Uniformity of size, spherical shape of droplet, and absence of clusters were confirmed by transmission electronic microscopy. The zeta potential was −34.7±1.15 mV. The nanoemulsion showed a moderate degree of skin irritation in the agarose overlay assay in vitro. The content of the extract markers, myrsinoic acids A and B, was 54.10±0.08 and 53.03 μg/g in the formulation, respectively. The formulation demonstrated pseudoplastic and thixotropic rheological behavior. In vitro release of chemical markers was controlled by diffusion mechanism. An extract-loaded nanoemulsion showed a topical anti-inflammatory activity in a croton oil-induced edema ear model, with a decrease in tumor necrosis factor release and myeloperoxidase activity. The nanoemulsion was 160% more efficient than the conventional cream containing 0.13% of the extract. The nanoemulsion showed suitable properties as a carrier for topical use of R. ferruginea extract and the approach for improving the topical anti-inflammatory activity. PMID:27660442

  16. Results of an Interview Study as Basis for the Categorization of ...

    African Journals Online (AJOL)

    This work is a report of a micro study carried out on the' effects of higher-order cognitive skills-oriented teaching strategy on the performance of senior secondary school chemistry students in solving stoichiometric problems'. In this study, problem solving category was used as one of the independent variables. This micro ...

  17. Science of the Brain as a Gateway to Understanding Play: An Interview with Jaak Panksepp

    Science.gov (United States)

    American Journal of Play, 2010

    2010-01-01

    Jaak Panksepp, known best for his work on animal emotions and coining the term "affective neuroscience," investigates the primary processes of brain and mind that enable and drive emotion. As an undergraduate, he briefly considered a career in electrical engineering but turned instead to psychology, which led to a 1969 University of…

  18. Creativity in ethnographic interviews

    DEFF Research Database (Denmark)

    Kauffmann, Lene Teglhus

    2014-01-01

    The article discusses interviews as participatory reflexive observation. It is based on experiences of interviewing policymakers and researchers about knowledge and evidence in health promotion. This particular group of informants challenged an approach to interviews as getting informants to desc...... of knowledge production and points out the role of the researcher as an active participant in the creative process....... to describe their everyday work life. By employing a methodological framework focusing on reflexive processes, interviews became consensual interactions, and the content of the interviews turned out to be analyses, interpretations and meaning making, that is, knowledge production. Interpretation and meaning...... making drew on ideologies, norms and values central to the field and thereby the strategies employed by the informants as well as by the researcher could be seen as wayfaring strategies; creating the paths in the field as they go along. Such an approach to interviews opens up the creative character...

  19. Lavender-thymol as a new topical aromatherapy preparation for episiotomy: A randomised clinical trial.

    Science.gov (United States)

    Marzouk, T; Barakat, R; Ragab, A; Badria, F; Badawy, A

    2015-01-01

    The objective of this study was to evaluate the effectiveness of topical lavender-thymol in promoting episiotomy healing. This placebo-controlled, single-blinded, randomised clinical trial involved 60 primiparous women. REEDA score was used to evaluate the outcome of the trial. On the 7th post-partum day, women in Placebo-treated group had worse Redness, Edema, Ecchymosis, Discharge and Approximation (REEDA) score of 3.93 ± 3.65 compared with those in Lavender-thymol-treated group (2.03 ± 1.7) with significant difference (P = 0.013). Visual analogue Scale (VAS) score for pain at episiotomy in Lavender-thymol-treated group was 3.5 ± 1.9, whereas in Placebo-treated group it was 2.1 ± 2.2 (p = 0.011) for dyschezia, 3.8 ± 1.7 and 2.8 ± 1.6 in Placebo- and Lavender-thymol-treated women, respectively (p = 0.023). At 7th post-partum week, dyspareunia was more severe in Placebo-treated group compared with that in Lavender-thymol-treated group (5.3 ± 2.7 vs 2.7 ± 1.5 and p aromatherapy using lavender-thymol was highly effective, suitable and safe for episiotomy wound care with little or no expected side effects compared with that using placebo.

  20. [Quality assurance as the topic in medical periodicals. Results of a literature search].

    Science.gov (United States)

    Thomeczek, C; Ollenschläger, G

    1997-02-01

    Against the background of the increasing importance of quality assurance procedures for the medical profession, it was questioned to which extend the topic "quality assurance" is content in medical journals. The frequency of articles with the key word "quality assurance" in German journals for the period from 1/1992 to 9/1996 was analyzed by using a literature search on Knowledge Finder's Health Star database. Journals for the clinical physician and the physician in the medical practice, that listed more than 200 articles, were taken into account. By using the key word "quality assurance", 276 articles were found (79 in 6 interdisciplinary journals, 197 in 22 medical journals). Interdisciplinary journals published between 8 and 25 (median: 13, rank 1: Zeitschrift für ärztliche Fortbildung), medical journals between 2 and 56 (median 13, rank 1: Chirurg). This analysis leads to the conclusion that a comprehensive continuing education about medical and interdisciplinary aspects of quality assurance in medicine only by reading common German medical journals may not be sufficient.

  1. Mystical experience relational language as a way of Teresa sanjuanista loving openness to others. Interview with Maximiliano Garcia Herraiz, OCD

    Directory of Open Access Journals (Sweden)

    ALALITE Argentina

    2015-04-01

    Full Text Available Maximiliano Herraiz García OCD, Carmelite saints founders specialist and writer career and international recognition, Spanish by birth lived for ten years in Africa, and has traveled five continents evangelizing through the Carmelite mystics in dialogue with universal mysticism, now convinced of experiential dimension of faith. In this interview he reflects on the relationship between mystical experience and language, linking mission and mystical literature. As part of the preparation for the Fifth Centenary of the Birth of Teresa of Avila, highlights the urgency of considering his theology of friendship and ascetic mysticism as roads for the current century Christianity.

  2. Misselling as a New Topic of Financial Education? A Didactic Analysis of Investment Advise after the Financial Crisis

    Directory of Open Access Journals (Sweden)

    Dirk Loerwald

    2010-07-01

    Full Text Available Personal financial investments are, as a matter of course, a topic of economic education because they are a life situation which is inherently economical. In contrast, faulty advising in banks which has become focussed upon due to the extent it has played a part in the recent financial crisis is mentioned neither in curricula nor in educational text books. Numerous private funds have been exposed as unprofitable investments. One reason for this problem is to be found in the marketing staff of the banks who did not invest their customer’s funds securely enough – and the customers did not notice it. What conclusions can be drawn from this for general financial education after the financial crisis? The economic education has failed to address the topic of “faulty advising in banks” as well. On the basis of categorical economic didactics the following contribution will analyse whether one has an exemplary case here upon which students can win generalized, transferable insights. In this context, the topic of personal financial investments will be classified in an efficient manner and the risk of opportunism in advising situations will be analysed with the help of the positive principal-agent theory. The results of this analysis of informational asymmetries within financial markets give direction to the development and revision of curricula in the didactics of economic education. With the following article a sustainable theoretical fundament will be created to underscore the obligatory inclusion of this topic in curricula as well as its realisation for target groups in school text books.

  3. Effect of topical antiglaucoma medications on late pupillary light reflex, as evaluated by pupillometry

    Directory of Open Access Journals (Sweden)

    Shakoor eBa-Ali

    2015-04-01

    Full Text Available Purpose: The late post-illumination pupillary response (PIPR10-30s to blue light is reduced in glaucoma, suggesting that pupillometry can be used in clinical glaucoma evaluation. Since animal studies have indicated that common anti-glaucomatous agents affect the iris muscle, we investigated the short term effect of the antiglaucoma drugs on the pupillary light reflex and in particular on the PIPR10-30s.Methods: In this randomized, double-masked, crossover trial, pupillometry was performed before and after topical administration of latanoprost, dorzolamide and timolol in 20 healthy subjects. Stimulus was blue- (463 nm and red light (633 nm of 2 log (lux. Main outcome was the PIPR10-30s to blue light. Additionally, pupil size, maximal contraction and the early post-illumination pupillary response (PIPR0-10s to blue- and red light were investigated. Pupil response variations between 8 AM and 2 PM were also assessed. IOP was measured before and 3.5 h after drug instillation. Results: We found no drug effect on the blue light PIPR10-30s or any other blue light pupil parameters. During the control day, the only significant variation over time was observed for the red light PIPR0-10s (p = 0.02. Pupillary size decreased slightly with timolol (0.1 mm, p = 0.03 and dorzolamide (0.2 mm, p < 0.001, but not with latanoprost. Timolol also reduced the maximal contraction amplitude significantly during red light (p = 0.02. IOP was significantly reduced by all three drugs after 3.5 hours (p < 0.01, while it remained unchanged during the control day (p = 0.3. Conclusion: Antiglaucoma medications did not interfere with the blue light elicited PIPR. Dorzolamide reduced pupil size, while timolol reduced both pupil size and maximal contraction to red light, but the effect was minute and not of clinical importance.

  4. Bimatoprost Topical

    Science.gov (United States)

    ... not use a cotton swab or any other brush or applicator to apply topical bimatoprost.To use the solution, follow these steps: Wash your hands and face thoroughly with soap and water. Be sure that ...

  5. Ciclopirox Topical

    Science.gov (United States)

    Ciclopirox topical solution is used along with regular nail trimming to treat fungal infections of the fingernails and toenails (an infection that may cause nail discoloration, splitting and pain). Ciclopirox is in a ...

  6. Enhanced information regarding exercise training as treatment is needed. An interview study in patients with chronic obstructive pulmonary disease.

    Science.gov (United States)

    Nordvall Strömberg, Petronella; Fjellman-Wiklund, Anncristine; Wadell, Karin

    2015-01-01

    The purpose of this study is to describe thoughts and attitudes of patients with chronic obstructive pulmonary disease (COPD) when talking about exercise training as treatment. Semi-structured interviews were performed and analyzed with the grounded theory method. Four men and six women were interviewed (ages 66-84 years), with moderate to severe COPD, and no experience of organized exercise training as treatment for COPD. The analysis resulted in one core category, unknown territory, and three categories, good for those who can, but not for me; fear of future; and mastering. Exercise training as treatment was perceived by the participants as something unknown. It was also described as important for others but not for them. Their perceptions were that they could not perform exercise training, and did not have the knowledge of what or how to perform exercise that was good for them. Patients with COPD, with no previous experience of exercise training as treatment for their disease, describe exercise training as something unknown and unimportant for them. The results provide important knowledge for healthcare professionals regarding how to educate patients with COPD about the content and benefits of exercise training as treatment. Implications for Rehabilitation Exercise training is effective for patients with chronic obstructive pulmonary disease (COPD) with regard to dyspnea, physical capacity, health-related quality of life, and health care use. Patients with COPD perceive a lack of information regarding exercise training as treatment. The information and the presentation of exercise training as treatment might be of importance to get better adherence to this treatment.

  7. Health professionals perceive teamwork with relatives as an obstacle in their daily work - a focus group interview.

    Science.gov (United States)

    Laursen, Jannie; Broholm, Malene; Rosenberg, Jacob

    2017-09-01

    Health professionals must often balance between different rationalities within the hospital organisation. Having adequate time with patients, shorter waiting time and the ability to greater professional autonomy have been shown to help provide a higher quality of care. Empathy and sympathy appear to be crucial components for the health professionals and their relationship to patients. The aim of this study was to explore health professionals' experiences of relatives to critically ill patients in order to identify aspects that may facilitate a better understanding of this teamwork. The study was descriptive and exploratory and had a qualitative design with a phenomenological/hermeneutic orientation for the interviews. Focus group was the chosen methodology. The study comprised 19 health professionals in four focus groups. Two themes emerged from the interviews: the hospital culture does not integrate relatives, and health professionals felt that relatives took their resources and saw them as an obstacle in their daily work. Health professionals felt divided between the system and the individual sphere, which makes it difficult for them to integrate relatives more and see them as participants in a natural teamwork for the benefit of the patient. © 2016 Nordic College of Caring Science.

  8. A Summary of Information on the Behavior of the Yakima Fold Belt as a Structural Entity -- Topical Report

    Energy Technology Data Exchange (ETDEWEB)

    Last, George V.; Winsor, Kelsey; Unwin, Stephen D.

    2012-08-01

    This document is one in a series of topical reports compiled by the Pacific Northwest National Laboratory to summarize technical information on selected topics important to the performance of a probabilistic seismic hazard analysis (PSHA) of the Hanford Site. The purpose of this report is to summarize available data and analyses relevant to the Yakima Fold Belt (YFB) that may bear on the question of whether or not the YFB behaves as a single seismotectonic province in which activity along one fold structure is representative of behavior along all other fold structures. This topic has met with a fairly high level of contention in the expert community and has the potential to result in significant impacts on an evaluation of seismic hazard at the Hanford Site. This report defines the relevant alternative conceptual models relevant to this technical issue and the arguments and data that support those models. It provides a brief description of the technical issue and principal uncertainties; a general overview on the nature of the technical issue, along with alternative conceptual models, supporting arguments and information, and uncertainties; and finally, it suggests some possible approaches for reducing uncertainties regarding this issue.

  9. Concept mapping as a method to teach an evidence-based educated medical topic: a comparative study in medical students.

    Science.gov (United States)

    Saeidifard, Farzane; Heidari, Kazem; Foroughi, Moein; Soltani, Akbar

    2014-01-01

    The objective of this study was to compare concept mapping with lecture-based method in teaching of evidence based educated topic to medical students. This randomized controlled trial was carried out on medical students during sixth year of 7-year MD curriculum clerkship phase. Cluster randomization was used to divide students into intervention and control groups. Both groups, at the beginning, were taught "Diabetic Ketoacidosis" (DKA) using evidence-based tool named Critically Appraised Topics (CAT). Students of intervention group were taught construction of concept maps on DKA and in the control group students had a lecture and a group discussion about what they had been taught on DKA. In the end, all of the students had an exam that they had to answer to 7 questions following to two clinical scenarios. The questions addressed physiopathology, diagnosis and treatment of patients with DKA and were scored separately. Sum of these scores was considered as total score. Scores were compared between intervention and control groups. Seventy six medical students (28 male, 48 female) were participated in this study. Total score among intervention group was higher than control group (78.2% vs. 72.5%, p concept mapping method was more successful in education of evidence-based educated topic via CATs in comparison with lecture-based method. Interpretation of this finding would be the concept mapping method may develop meaningful learning among medical students.

  10. Life-history interviews

    DEFF Research Database (Denmark)

    Adriansen, Hanne Kirstine

    2010-01-01

    My first encounter with life history research was during my Ph.D. research. This concerned a multi-method study of nomadic mobility in Senegal. One method stood out as yielding the most interesting and in-depth data: life story interviews using a time line. I made interviews with the head...... of a time line for making life story interviews. I decided that the lack of authoritative literature should not omit me from teaching my students how to make a time line interview. After an introduction, they had to use the tool for making an interview each other concerning their learning journey to DPU...... for conducting life history research. While I also consider time line interviews useful for other types of research, that story will have to wait for another paper....

  11. The emergence and institutional co-determination of sustainability as a teaching topic in interdisciplinary science teacher education

    DEFF Research Database (Denmark)

    Rasmussen, Klaus

    2016-01-01

    and constrained by a complex web of interactions in and among the teaching disciplines of biology, geography and physics/chemistry and among the institutions of school, teacher college and university. The data collected are used to identify influences among the disciplines as well as disciplinary differences......, conceptualised through a new reference model that separates the analysis from the usual sustainability dimensions. The findings reveal how sustainability as a teaching topic can be a unifying idea in an interdisciplinary setting. Disciplinary differences evidently impact course planning and implementation...

  12. Isolation and prayer as means of solace for Arab women with breast cancer: An in-depth interview study.

    Science.gov (United States)

    Assaf, Ghada Najjar; Holroyd, Eleanor; Lopez, Violeta

    2017-11-01

    This study explored Arab women's experiences following the diagnosis and treatment of breast cancer. Face-to-face in-depth interviews were conducted with 20 Arab women attending a public hospital in Abu Dhabi, United Arab Emirates, following a recent diagnosis of breast cancer. All interviews were transcribed verbatim and analysed using the thematic method. Arab women's experiences following their breast cancer diagnoses and treatments included the themes of (1) protecting one's self from stigma, (2) facing uncertainties and prayers, and (3) getting on with life. Overall, the ways to find solace were through isolation and prayer, which are heavily influenced by religion and spiritual practices. They recommended that to help women with breast cancer, a campaign to raise awareness for early screening is needed as well the need to form a peer-led support group for women with breast cancer consisting of breast cancer survivors so that they can learn from each other's experiences. Arab women with breast cancer experienced a myriad of social, cultural, psychological, and relationship difficulties that impacted their overall health and well-being. The findings also found that these women were not passive agents. They sought to solve problem, move forward, and recreate the meanings in their lives in their own unique ways. Action is needed for possible ways to implement religion-health partnerships between breast cancer nurses, peer-led support groups, palliative care services, and religious institutions. Copyright © 2017 John Wiley & Sons, Ltd.

  13. Confirming mental health care in acute psychiatric wards, as narrated by persons experiencing psychotic illness: an interview study.

    Science.gov (United States)

    Sebergsen, Karina; Norberg, Astrid; Talseth, Anne-Grethe

    2016-01-01

    It is important that mental health nurses meet the safety, security and care needs of persons suffering from psychotic illness to enhance these persons' likelihood of feeling better during their time in acute psychiatric wards. Certain persons in care describe nurses' mental health care as positive, whereas others report negative experiences and express a desire for improvements. There is limited research on how persons with psychotic illness experience nurses' mental health care acts and how such acts help these persons feel better. Therefore, the aim of this study was to explore, describe and understand how the mental health nurses in acute psychiatric wards provide care that helps persons who experienced psychotic illness to feel better, as narrated by these persons. This study had a qualitative design; 12 persons participated in qualitative interviews. The interviews were transcribed, content analysed and interpreted using Martin Buber's concept of confirmation. The results of this study show three categories of confirming mental health care that describe what helped the participants to feel better step-by-step: first, being confirmed as a person experiencing psychotic illness in need of endurance; second, being confirmed as a person experiencing psychotic illness in need of decreased psychotic symptoms; and third, being confirmed as a person experiencing psychotic illness in need of support in daily life. The underlying meaning of the categories and of subcategories were interpreted and formulated as the theme; confirming mental health care to persons experiencing psychotic illness. Confirming mental health care acts seem to help persons to feel better in a step-wise manner during psychotic illness. Nurses' openness and sensitivity to the changing care needs of persons who suffer from psychotic illness create moments of confirmation within caring acts that concretely help the persons to feel better and that may enhance their health. The results show the

  14. Diflorasone Topical

    Science.gov (United States)

    ... area, do not use tight-fitting diapers or plastic pants. Such use may increase side effects.Do not apply other skin preparations or products ... doctor.if you are having surgery, including dental surgery, tell the doctor or dentist that you are using betamethasone topical.

  15. Betamethasone Topical

    Science.gov (United States)

    ... area, do not use tight-fitting diapers or plastic pants. Such use may increase side effects.Do not apply other skin preparations or products ... immediately.if you are having surgery, including dental surgery, tell the doctor or dentist that you are using betamethasone topical.

  16. Halcinonide Topical

    Science.gov (United States)

    ... area, do not use tight-fitting diapers or plastic pants. Such use may increase side effects.Do not wrap or bandage the treated area ... doctor.if you are having surgery, including dental surgery, tell the doctor or dentist that you are using halcinonide topical.

  17. Fluocinonide Topical

    Science.gov (United States)

    ... area, do not use tight-fitting diapers or plastic pants. Such use may increase side effects.Do not apply other skin preparations or products ... immediately.if you are having surgery, including dental surgery, tell the doctor or dentist that you are using fluocinonide topical.

  18. Dapsone Topical

    Science.gov (United States)

    ... go away: skin redness or burning skin drying skin oiliness and peeling itching Some side effects can be serious. If you experience any of these symptoms, stop using dapsone and call ... yellow or pale skin Dapsone topical may cause other side effects. Call ...

  19. Mometasone Topical

    Science.gov (United States)

    ... a few drops on the affected areas and massage lightly until it disappears.This medication is only for use on the skin. Do not let mometasone topical get into your eyes or mouth and do not swallow it. Avoid use on the face, in the genital and rectal areas, and in ...

  20. Rheological, mechanical and adhesive properties of surfactant-containing systems designed as a potential platform for topical drug delivery.

    Science.gov (United States)

    Carvalho, Flávia Chiva; Rocha e Silva, Hilris; da Luz, Gabriela Marielli; Barbi, Mariana da Silva; Landgraf, Daniele Silveira; Chiavacci, Leila Aparecida; Sarmento, Victor Hugo Vitorino; Gremião, Maria Palmira Daflon

    2012-04-01

    In the last few decades, nanotechnology has led to an advance in the development of topical drug delivery. Nanostructured drug delivery systems enable the compartmentalization of drugs in restricted environments, modifying the release profile and maintaining the required drug concentration for prolonged periods at the site of action and/or absorption. The development of nanostructured systems containing surfactants has evolved rapidly. Mixtures of surfactant, oil and water can self-associate to form structures, such as microemulsions and liquid crystal phases, which can be exploited as drug delivery systems because their nanostructured organization can control drug release. Therefore, the purpose of this study was to assess the potential of systems containing polyoxypropylene (5) polyoxyethylene (20) cetyl ether as surfactant, oleic acid or mineral oil as the oily phase, and water to be used as a platform in the development of topical drug delivery systems. Physicochemical characterization of the systems was performed by polarized light microscopy (PLM), small-angle X-ray scattering (SAXS), rheological tests and texture profile analysis. The ternary phase diagrams showed that combinations of surfactant/mineral oil/water and surfactant/oleic acid/water could form various thermodynamically stable structures, such as microemulsions and liquid crystals. The oily phases, oleic acid and mineral oil, changed the rheological, mechanical and adhesive properties of systems containing polyoxypropylene (5) polyoxyethylene (20) cetyl ether.

  1. Psycho-neural Identity as the Basis for Empirical Research and Theorization in Psychology: An Interview with Mario A. Bunge

    Science.gov (United States)

    Virues-Ortega, Javier; Hurtado-Parrado, Camilo; Martin, Toby L.; Julio, Flávia

    2012-10-01

    Mario Bunge is one of the most prolific philosophers of our time. Over the past sixty years he has written extensively about semantics, ontology, epistemology, philosophy of science and ethics. Bunge has been interested in the philosophical and methodological implications of modern psychology and more specifically in the philosophies of the relation between the neural and psychological realms. According to Bunge, functionalism, the philosophical stand of current psychology, has limited explanatory power in that neural processes are not explicitly acknowledged as components or factors of psychological phenomena. In Matter and Mind (2010), Bunge has elaborated in great detail the philosophies of the mind-brain dilemma and the basis of the psychoneural identity hypothesis, which suggests that all psychological processes can be analysed in terms of neural and physical phenomena. This article is the result of a long interview with Dr. Bunge on psychoneural identity and brain-behaviour relations.

  2. Lack of instrumental hydrological data? Trying the use of interviews as a way to estimate the regime of temporary streams.

    Science.gov (United States)

    Gallart, Francesc; Llorens, Pilar; Latron, Jérôme; Cid, Núria; Rieradevall, Maria; Prat, Narcís

    2015-04-01

    Temporary streams are those that undergo the recurrent cessation of flow or the complete drying of the stream bed. Although they may represent the main part of the elementary drainage network, or even most of the total network in some areas due to climatic or lithological reasons, temporary streams are rarely included in stream monitoring networks. As a result, hydrological data for assessing the regime of temporary streams are often scarce. The LIFE TRivers project is developing a software (TREHS, Temporary Rivers' Ecological and Hydrological Status), which is designed to help the managers for adequately implement the Water Framework Directive in this type of water bodies. The first need for managing a temporary stream is the characterisation of its hydrological regime, in order to help managers selecting appropriate sampling dates and using the right methods to determine its ecological status. Yet, the deviation of the actual regime from the natural one should be determined in order to assess the potential hydrological alteration due to the human activity and thereby determine the 'hydrological status'. TREHS applies a methodology for regime characterisation based on the results of the EU FP7 project MIRAGE. This methodology is based on the assessment of the temporal patterns of six 'aquatic states' that summarize the transient sets of mesohabitats occurring on a given reach at a particular moment, depending on the hydrological conditions. The qualitative nature of the aquatic states allowed the use of interviews to assess the regime of the streams in the lack of observed flow data. For the questionnaires, the TREHS temporal scheme was simplified from a monthly to a seasonal one and the aquatic states were reduced from six to three (flow, pools and dry). To validate the methodology based on the use of interviews, inhabitants of villages and small towns near to gauging stations were asked to fill the questionnaire. The preliminary results on temporary stream

  3. Balancing Constraints and the Sweet Spot as Coming Topics for Creativity Research

    DEFF Research Database (Denmark)

    Onarheim, Balder; Biskjaer, Michael Mose

    2017-01-01

    The aim of this chapter is the introduction of two new concepts, ‘balancing constraints’ and ‘the sweet spot of creativity’, as promising new paths for creativity research. This is motivated by the fact that creativity research shows a growing interest in the fundamental entwinement of constraints...... and creativity, with skillful and innovative handling of constraints seen as a prerequisite for apt creative performance. Based on a brief review of current disparate conceptualizations of constraints as both enablers and restrainers of creative activities, we begin by proposing the unifying concept ‘creativity...... the salient situations where the creative practitioner can be said to experience the ‘right’ level of constrainedness conducive to optimum creative performance. We then proceed to consider how the sweet spot can be attained by balancing constraints, i.e., by manipulating the intensity of constrainedness. More...

  4. American National Identity in a Globalized World as a Topic in the Advanced EFL-Classroom

    Directory of Open Access Journals (Sweden)

    Peter Freese

    2008-06-01

    Full Text Available In order to make an issue as complex and controversial as that of ‘national identity’ teachable in the advanced EFL-classroom, it has to be reduced to exemplary aspects and illustrated with concrete examples. Therefore, I will suggest an appropriate ‘Course Opener,’ briefly survey the historical unfolding of the American identity concept in order to provide teachers with the necessary background knowledge, and then suggest two teaching units, the first of which traces some major developments by means of ‘classic’ texts, whereas the second deals with the crucial issue of whether a shared language is a prerequisite for a shared identity.

  5. Absorption of Bupivacaine after Administration of a Lozenge as Topical Treatment for Pain from Oral Mucositis

    DEFF Research Database (Denmark)

    Mogensen, Stine; Sverrisdóttir, Eva; Sveinsdóttir, Kolbrún

    2017-01-01

    The aim was to investigate systemic exposure after administration of a novel bupivacaine lozenge in healthy individuals with normal mucosa and in head and neck cancer (HNC) patients with oral mucositis. A lozenge containing 5, 10, 25 and 50 mg bupivacaine, respectively, was administered as single......, respectively, after administration. The plasma concentration-time profiles of bupivacaine were fitted to pharmacokinetic models using nonlinear mixed-effects modelling, evaluating demographics and health status as covariates. The population pharmacokinetics (PK) of bupivacaine lozenge was best described...

  6. Learning Mathematics or Losing Money--Betting as a Topic for Mathematical Education

    Science.gov (United States)

    Siller, Hans-Stefan; MaaB, Jurgen

    2012-01-01

    No risk, no fun--betting on sports events costs the gamblers a lot of money and brings excellent profits to those who offer the bets. Among the people who bet on a regular basis, the proportion of young adults is frighteningly high. We now suggest a concept (as part of a basic mathematics course) for acquiring the necessary mathematical knowledge…

  7. New lidocaine lozenge as topical anesthesia compared to lidocaine viscous oral solution before upper gastrointestinal endoscopy

    DEFF Research Database (Denmark)

    Mogensen, Stine; Treldal, Charlotte; Feldager, Erik

    2012-01-01

    To evaluate the effect and acceptance of a new lidocaine lozenge compared with a lidocaine viscous oral solution as a pharyngeal anesthetic before upper gastrointestinal endoscopy (UGE), a diagnostic procedure commonly performed worldwide during which many patients experience severe discomfort mo...

  8. Inorganic layered double hydroxides as a 4-hexyl resorcinol delivery system for topical applications

    CSIR Research Space (South Africa)

    Mosangi, Damodar

    2016-08-01

    Full Text Available In this study, the hydrophobic even skin tone active, 4-hexylresorcinol (HR), was intercalated into a zinc aluminium layered double hydroxide (ZnAl-LDH) by a co-precipitation method and used as a controlled release ingredient in skin care...

  9. Structured Interviews: Developing Interviewing Skills in Human Resource Management Courses

    Science.gov (United States)

    Doll, Jessica L.

    2018-01-01

    Structured interviews are widely used in the employment process; however, students often have little experience asking and responding to structured interview questions. In a format similar to "speed dating," this exercise actively engages students in the interview process. Students pair off to gain experience as an interviewer by asking…

  10. Absorption of Bupivacaine after Administration of a Lozenge as Topical Treatment for Pain from Oral Mucositis.

    Science.gov (United States)

    Mogensen, Stine; Sverrisdóttir, Eva; Sveinsdóttir, Kolbrún; Treldal, Charlotte; Jensen, Kenneth; Jensen, Anders Bonde; Kristensen, Claus Andrup; Jacobsen, Jette; Kreilgaard, Mads; Petersen, Janne; Andersen, Ove

    2017-01-01

    The aim was to investigate systemic exposure after administration of a novel bupivacaine lozenge in healthy individuals with normal mucosa and in head and neck cancer (HNC) patients with oral mucositis. A lozenge containing 5, 10, 25 and 50 mg bupivacaine, respectively, was administered as single dose to 10 healthy individuals, and a lozenge containing 25 mg bupivacaine was administered as single dose to 10 HNC patients with oral mucositis and as multiple doses to five patients with HNC. Blood samples were collected for 6 hr from the healthy individuals and 3 hr from the patients with HNC, respectively, after administration. The plasma concentration-time profiles of bupivacaine were fitted to pharmacokinetic models using nonlinear mixed-effects modelling, evaluating demographics and health status as covariates. The population pharmacokinetics (PK) of bupivacaine lozenge was best described by a two-compartment distribution model with absorption transit compartments. All the observed plasma concentrations were well below the bupivacaine concentrations (2000-2250 ng/ml) which have caused toxic symptoms. The PK model suggested that relative bioavailability was two times higher in HNC patients with oral mucositis grade 1-2 and three times higher in HNC patients with oral mucositis grade 3-4 than in the healthy individuals. Simulations showed that the plasma concentrations would be below the toxic limit after repeated dosing every second hour with 25 mg bupivacaine for five days. The 25-mg bupivacaine lozenges were safe without systemic toxic levels of bupivacaine or risk of side effects. Based on PK simulations of repeated doses of 25 mg every two hours for 16 hr a day, the lozenges can be administered with minimum risk of exceeding the toxic limit. © 2016 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).

  11. HIImesophase as a drug delivery system for topical application of methyl salicylate.

    Science.gov (United States)

    Liang, Xin; Chen, Yu-Lin; Jiang, Xiao-Jing; Wang, Sheng-Mei; Zhang, Ji-Wen; Gui, Shuang-Ying

    2017-03-30

    The main objective of this study was to develop reversed hexagonal (H II ) mesophase for transdermal delivery of methyl salicylate. The formulation was prepared, characterized and evaluated for its skin penetration in vitro and skin retention in vivo. Preliminary pharmacodynamics and skin irritation were also investigated. The formulation was identified as hexagonal structure. In vitro study exhibited that H II mesophase enhanced the skin permeation by delivering 2.61 times more methyl salicylate than the commercially available cream. Meanwhile, H II mesophase presented higher bioavailability as AUC (0-24) and AUC (0-∞) were 32.894μg·mL -1 and 32.935μg·mL -1 respectively, while the cream were 12.791μg·mL -1 and 12.970μg·mL -1 . Preliminary pharmacodynamics studies demonstrated that H II mesophase possessed anti-inflammatory and analgesic effects for inhibiting paw edema, granuloma and pain. MeSa H II mesophase showed no skin irritation on the normal rat skin. Thus, H II mesophase was considered as an effective delivery system for MeSa. Copyright © 2016. Published by Elsevier B.V.

  12. The potential of Ganoderma lucidum extracts as bioactive ingredients in topical formulations, beyond its nutritional benefits.

    Science.gov (United States)

    Taofiq, Oludemi; Heleno, Sandrina A; Calhelha, Ricardo C; Alves, Maria José; Barros, Lillian; González-Paramás, Ana M; Barreiro, Maria F; Ferreira, Isabel C F R

    2017-10-01

    Ganoderma lucidum was characterized in terms of nutritional value and chemical composition. Thereafter, ethanolic Soxhlet extracts were evaluated for antioxidant, anti-inflammatory, antityrosinase, antimicrobial and cytotoxic effects, and further characterized in terms of phenolic acids, polysaccharides and triterpenoids. Finally, the obtained extracts were tested as cosmeceutical ingredients. G. lucidum proved to be a source of macronutrients and important bioactive compounds such as terpenoids, specially triterpenoids, and polysaccharides. In the extracts, ganoderic acids C2, A and H were the most abundant triterpenic acids and protocatechuic, p-hydroxibenzoic and syringic acids the identified phenolics. The developed cosmeceutical formulation preserved the extract bioactivities, presented a light-yellow colour and a pH of 4.6, which is considered appropriate for cosmeceutical's design. Behind the important nutritional/bioactive composition of G. lucidum, a potential towards its valorisation in the field of cosmeceuticals is foreseeable, as deduced from the bioactivities of its ethanolic extract and preservation in the tested formulation. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. Interviewing Child Victims of Sexual Exploitation.

    Science.gov (United States)

    Spaulding, William

    The interviewing of the child victim of sexual exploitation is one of the first and most important steps in solving and prosecuting a case of child exploitation and is the topic of this document. The first chapter discusses the interviewer's role, focusing on improving communication, dealing with emotion, the interviewer's response, male or female…

  14. The use of botanical extracts as topical skin-lightening agents for the improvement of skin pigmentation disorders.

    Science.gov (United States)

    Zhu, Wenyuan; Gao, Jie

    2008-04-01

    Both physicians and dermatology patients are searching for long-term topical skin care solutions (both cosmetic and cosmeceutical) to address problems presented by skin hyperpigmentation. Specifically, some women often express a desire to "lighten" skin tone by achieving improved visible tone, reduction in yellowness (or sallow tone), and reduction in the appearance of hyperpigmented spots ("age" or "sun" spots). Traditional depigmenting agents, such as hydroquinone, corticosteroids, and kojic acid, although highly effective, can raise several safety concerns (for example, ochronosis, atrophy, carcinogenesis, and other local or systemic side effects) with long-term exposure. An understanding of the benefits of natural and botanical extracts provides opportunities to develop new products to address pigmentation problems. Active compounds isolated from plants, such as arbutin, aloesin, gentisic acid, flavonoids, hesperidin, licorice, niacinamide, yeast derivatives, and polyphenols, inhibit melanogenesis without melanocytotoxicity by different mechanisms. This review presents an overview of trends in the application of plant extracts as topical treatments for hyperpigmentation disorders. It highlights some of the most relevant natural extracts, providing in vitro screening results and relevant available clinical study trial findings supporting their efficacy.

  15. Evaluation of a polyherbal topical aerosol spray as a supportive therapy for clinical mastitis in dairy cows

    Directory of Open Access Journals (Sweden)

    Ramasamy Selvam

    2015-09-01

    Full Text Available The present study was designed to evaluate the polyherbal topical aerosol spray Wisprec and reg; Advanced (M/S. Natural Remedies Private Limited, India as a supportive therapy for clinical mastitis in dairy cows. A total of 41 dairy cows suffering from clinical mastitis were selected, and Wisprec and reg; Advanced was sprayed on mastitis affected quarters of udder two times a day along with a parenteral antibiotic till complete recovery. The rectal temperature, pain on palpation of udder, swelling of udder, consistency of milk, recovery period and product satisfaction score were assessed to evaluate the efficacy of Wisprec and reg; Spray. Topical application of Wisprec and reg; Advanced Spray have shown a significant improvement (p<0.001 in alleviation of rectal temperature, pain on palpation of udder and swelling of udder, and the consistency of milk was restored to normal after 3 to 4 days of treatment. The results demonstrate that the Wisprec and reg; Advanced spray could be considered as an alternative to non-steroidal anti-inflammatory drugs (NSAIDs as a supportive therapy for clinical mastitis of dairy cows. [J Adv Vet Anim Res 2015; 2(3.000: 285-290

  16. TOPICAL REVIEW: Metallo-supramolecular modules as a paradigm for materials science

    Directory of Open Access Journals (Sweden)

    Dirk G Kurth

    2008-01-01

    Full Text Available Metal ion coordination in discrete or extended metallo-supramolecular assemblies offers ample opportunity to fabricate and study devices and materials that are equally important for fundamental research and new technologies. Metal ions embedded in a specific ligand field offer diverse thermodynamic, kinetic, chemical, physical and structural properties that make these systems promising candidates for active components in functional materials. A key challenge is to improve and develop methodologies for placing these active modules in suitable device architectures, such as thin films or mesophases. This review highlights recent developments in extended, polymeric metallo-supramolecular systems and discrete polyoxometalates with an emphasis on materials science.

  17. Topical Review: Adolescent Self-Regulation as a Foundation for Chronic Illness Self-Management

    Science.gov (United States)

    Lansing, Amy Hughes

    2014-01-01

    Objective To illustrate adolescent self-regulation as a foundation for both individual and interpersonal processes in adolescent chronic illness self-management. Method Literature review. Results Research has identified multiple individual (e.g., self-efficacy, coping, and adherence) and interpersonal factors (parental monitoring and friend support) that are sources of risk and resilience to adolescent chronic illness self-management. In this article, we highlight literature consistent with the idea that self-regulation (including cognitive, emotional, and behavioral regulation) underlies both individual and interpersonal sources of risk and resilience across development. Conclusions This self-regulation approach has multiple benefits: A parsimonious construct for explaining both individual and interpersonal processes that contribute to risk and resilience for chronic illness self-management, the incorporation of methods used in developmental and health psychology research, including performance-based, physiological, daily, and ecological momentary assessment, and a new look to interventions that target self-regulation as a way to improve individual and interpersonal processes in chronic illness self-management. PMID:25214646

  18. Topical report on sources and systems for aquatic plant biomass as an energy resource

    Energy Technology Data Exchange (ETDEWEB)

    Goldman, J.C.; Ryther, J.H.; Waaland, R.; Wilson, E.H.

    1977-10-21

    Background information is documented on the mass cultivation of aquatic plants and systems design that is available from the literature and through consultation with active research scientists and engineers. The biology of microalgae, macroalgae, and aquatic angiosperms is discussed in terms of morphology, life history, mode of existence, and ecological significance, as they relate to cultivation. The requirements for growth of these plants, which are outlined in the test, suggest that productivity rates are dependent primarily on the availability of light and nutrients. It is concluded that the systems should be run with an excess of nutrients and with light as the limiting factor. A historical review of the mass cultivation of aquatic plants describes the techniques used in commercial large-scale operations throughout the world and recent small-scale research efforts. This review presents information on the biomass yields that have been attained to date in various geographical locations with different plant species and culture conditions, emphasizing the contrast between high yields in small-scale operations and lower yields in large-scale operations.

  19. Perceived Changes in Communication as an Effect of STN Surgery in Parkinson's Disease: A Qualitative Interview Study

    Directory of Open Access Journals (Sweden)

    Emilia Ahlberg

    2011-01-01

    Full Text Available The aim of the present study was to explore four individuals' perspective of the way their speech and communication changed as a result of subthalamic nucleus deep brain stimulation treatment for Parkinson's disease. Interviews of two men and two women were analyzed using qualitative content analysis. Three themes emerged as a result of the analysis. The first theme included sub-themes describing both increased and unexpected communication difficulties such as a more vulnerable speech function, re-emerging stuttering and cognitive difficulties affecting communication. The second theme comprised strategies to improve communication, using different speech techniques and communicative support, as well as trying to achieve changes in medical and stimulation parameters. The third theme included descriptions of mixed feelings surrounding the surgery. Participants described the surgery as an unavoidable dramatic change, associated both with improved quality of life but also uncertainty and lack of information, particularly regarding speech and communication changes. Despite negative effects on speech, the individuals were generally very pleased with the surgical outcome. More information before surgery regarding possible side effects on speech, meeting with a previously treated patient and possibly voice and speech therapy before or after surgery are suggested to facilitate the adjustment to the new speech conditions.

  20. Balancing Constraints and the Sweet Spot as Coming Topics for Creativity Research

    DEFF Research Database (Denmark)

    Onarheim, Balder; Biskjaer, Michael Mose

    2017-01-01

    The aim of this chapter is the introduction of two new concepts, ‘balancing constraints’ and ‘the sweet spot of creativity’, as promising new paths for creativity research. This is motivated by the fact that creativity research shows a growing interest in the fundamental entwinement of constraints...... constraints’ to help establish common terminological ground. Since the presence of constraints change over time, we suggest the term ‘constrainedness’ to articulate this total constraint intensity at a given time. This allows us to introduce our main contribution, the concept ‘the sweet spot’, to address...... the salient situations where the creative practitioner can be said to experience the ‘right’ level of constrainedness conducive to optimum creative performance. We then proceed to consider how the sweet spot can be attained by balancing constraints, i.e., by manipulating the intensity of constrainedness. More...

  1. Nanoemulsion as a carrier to improve the topical anti-inflammatory activity of stem bark extract of Rapanea ferruginea

    Directory of Open Access Journals (Sweden)

    Dal Mas J

    2016-09-01

    Full Text Available Juarana Dal Mas,1 Tailyn Zermiani,1 Liliani C Thiesen,1 Joana LM Silveira,2 Kathryn ABS da Silva,1 Márcia M de Souza,1 Angela Malheiros,1 Tania MB Bresolin,1 Ruth M Lucinda-Silva1 1NIQFAR, Graduate Program in Pharmaceutical Sciences, University of Vale do Itajaí, Itajaí, Santa Catarina, Brazil; 2Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, Paraná, Brazil Abstract: The aim of this study was to develop nanoemulsion containing soft extract of stem bark of Rapanea ferruginea to improve the topical delivery and anti-inflammatory activity. The extract of R. ferruginea stem bark was incorporated into the oily phase of the nanoemulsion by the method of phase inversion at low energy. The developed nanoemulsion had an average droplet size of 47.88±8.20 nm and a polydispersibility index of 0.228. Uniformity of size, spherical shape of droplet, and absence of clusters were confirmed by transmission electronic microscopy. The zeta potential was -34.7±1.15 mV. The nanoemulsion showed a moderate degree of skin irritation in the agarose overlay assay in vitro. The content of the extract markers, myrsinoic acids A and B, was 54.10±0.08 and 53.03 µg/g in the formulation, respectively. The formulation demonstrated pseudoplastic and thixotropic rheological behavior. In vitro release of chemical markers was controlled by diffusion mechanism. An extract-loaded nanoemulsion showed a topical anti-inflammatory activity in a croton oil-induced edema ear model, with a decrease in tumor necrosis factor release and myeloperoxidase activity. The nanoemulsion was 160% more efficient than the conventional cream containing 0.13% of the extract. The nanoemulsion showed suitable properties as a carrier for topical use of R. ferruginea extract and the approach for improving the topical anti-inflammatory activity. Keywords: nanotechnology, nanoemulsion, Rapanea ferruginea, anti-inflammatory, phytomedicine

  2. Ethosomes and liposomes as topical vehicles for azelaic acid: a preformulation study.

    Science.gov (United States)

    Esposito, Elisabetta; Menegatti, Enea; Cortesi, Rita

    2004-01-01

    The basic properties and the in vitro release rate kinetics of azelaic acid (AA), alternatively vehiculated in different phospholipid-based vesicles such as ethosomes or liposomes, were investigated. Ethosomes were produced by a simple method based on addition of an aqueous phase to an ethanol solution (comprised between 20\\% and 45%, v/v) of soy phosphatidyl choline (5%, w/w) and AA (0.2%, w/w) under mechanical stirring. Liposomes were obtained by the same composition in the absence of ethanol with the reverse-phase evaporation method. Vesicle size was measured by photon correlation spectroscopy (PCS), evidencing smaller mean diameters and narrower dimensional distributions in the case of ethosomes with respect to liposomes. In order to obtain homogeneously sized vesicles, both ethosomal and liposomal dispersions were extruded through polycarbonate membranes with pores of calibrated diameter (400 nm and 200 nm). Vesicle morphology was characterized by freeze-fracture scanning electron microscopy (SEM) showing the presence of unilamellar vesicles both in liposome- and in ethosome-based dispersions. Free energy measurements of the vesicle bilayers were conducted by differential scanning calorimetry (DSC). AA diffusion from ethosomal or liposomal dispersions and from ethosomes and liposomes incorporated in a viscous gel was investigated by a Franz cell assembled with synthetic membranes. The release rate was more rapid from ethosomal systems than from liposomal systems. In particular, ethosomes produced by the highest ethanol concentration released AA more rapidly, and the same trend was found using viscous forms.

  3. Propylene glycol liposomes as a topical delivery system for miconazole nitrate: comparison with conventional liposomes.

    Science.gov (United States)

    Elmoslemany, Riham M; Abdallah, Ossama Y; El-Khordagui, Labiba K; Khalafallah, Nawal M

    2012-06-01

    Propylene glycol (PG)-phospholipid vesicles have been advocated as flexible lipid vesicles for enhanced skin delivery of drugs. To further characterize the performance of these vesicles and to address some relevant pharmaceutical issues, miconazole nitrate(MN)-loaded PG nanoliposomes were prepared and characterized for vesicle size, entrapment efficiency, in vitro release, and vesicle stability. An issue of pharmaceutical importance is the time-dependent, dilution-driven diffusion of propylene glycol out of the vesicles. This was addressed by assessing propylene glycol using gas chromatography in the separated vesicles and monitoring its buildup in the medium after repeated dispersion of separated vesicles in fresh medium. Further, the antifungal activity of liposomal formulations under study was assessed using Candida albicans, and their in vitro skin permeation and retention were studied using human skin. At all instances, blank and drug-loaded conventional liposomes were included for comparison. The results provided evidence of controlled MN delivery, constant percent PG uptake in the vesicles (≈45.5%) in the PG concentration range 2.5 to 10%, improved vesicle stability, and enhanced skin deposition of MN with minimum skin permeation. These are key issues for different formulation and performance aspects of propylene glycol-phospholipid vesicles.

  4. Potential Use of Essential Oil Isolated from Cleistocalyx operculatus Leaves as a Topical Dermatological Agent for Treatment of Burn Wound.

    Science.gov (United States)

    Tran, Gia-Buu; Le, Nghia-Thu Tram; Dam, Sao-Mai

    2018-01-01

    Several herbal remedies have been used as topical agents to cure burn wound, one of the most common injuries in worldwide. In this study, we investigated the potential use of Cleistocalyx operculatus essential oil to treat the burn wound. We identified a total of 13 bioactive compounds of essential oil, several of which exhibited the anti-inflammatory and antimicrobial activities. Furthermore, the essential oil showed the antibacterial effect against S. aureus but not with P. aeruginosa. The supportive effect of essential oil on burn wound healing process also has been proven. Among three groups of mice, wound contraction rate of essential oil treated group (100%) was significantly higher than tamanu oil treated (79%) and control mice (71%) after 20 days (0.22 ± 0.03 versus 0.31 ± 0.02 cm 2 , resp., p essential oil formed a complete epidermal structure, thick and neatly arranged fibers, and scattered immune cells in burn wound. On the contrary, saline treated burn wound formed uneven epidermal layer with necrotic ulcer, infiltration of immune cells, and existence of granulation tissue. This finding demonstrated Cleistocalyx operculatus essential oil as promising topical dermatological agent to treat burn wound.

  5. Novel alginate-based nanocarriers as a strategy to include high concentrations of hydrophobic compounds in hydrogels for topical application

    Science.gov (United States)

    Nguyen, H. T. P.; Munnier, E.; Souce, M.; Perse, X.; David, S.; Bonnier, F.; Vial, F.; Yvergnaux, F.; Perrier, T.; Cohen-Jonathan, S.; Chourpa, I.

    2015-06-01

    The cutaneous penetration of hydrophobic active molecules is of foremost concern in the dermatology and cosmetic formulation fields. The poor solubility in water of those molecules limits their use in hydrophilic forms such as gels, which are favored by patients with chronic skin disease. The aim of this work is to design a novel nanocarrier of hydrophobic active molecules and to determine its potential as an ingredient of a topical form. The nanocarrier consists of an oily core surrounded by a protective shell of alginate, a natural polysaccharide isolated from brown algae. These calcium alginate-based nanocarriers (CaANCs) were prepared at room temperature and without the use of organic solvent by an accelerated nanoemulsification-polymer crosslinking method. The size (hydrodynamic diameter ˜200 nm) and surface charge (zeta potential ˜ - 30 mV) of the CaANCs are both compatible with their application on skin. CaANCs loaded with a fluorescent label were stable in model hydrophilic galenic forms under different storage conditions. Curcumin was encapsulated in CaANCs with an efficiency of ˜95%, fully retaining its antioxidant activity. The application of the curcumin-loaded CaANCs on excised human skin led to a significant accumulation of the active molecules in the upper layers of the skin, asserting the potential of these nanocarriers in active pharmaceutical and cosmetic ingredients topical delivery.

  6. Novel alginate-based nanocarriers as a strategy to include high concentrations of hydrophobic compounds in hydrogels for topical application

    International Nuclear Information System (INIS)

    Nguyen, H T P; Munnier, E; Souce, M; Perse, X; David, S; Bonnier, F; Cohen-Jonathan, S; Chourpa, I; Vial, F; Yvergnaux, F; Perrier, T

    2015-01-01

    The cutaneous penetration of hydrophobic active molecules is of foremost concern in the dermatology and cosmetic formulation fields. The poor solubility in water of those molecules limits their use in hydrophilic forms such as gels, which are favored by patients with chronic skin disease. The aim of this work is to design a novel nanocarrier of hydrophobic active molecules and to determine its potential as an ingredient of a topical form. The nanocarrier consists of an oily core surrounded by a protective shell of alginate, a natural polysaccharide isolated from brown algae. These calcium alginate-based nanocarriers (CaANCs) were prepared at room temperature and without the use of organic solvent by an accelerated nanoemulsification-polymer crosslinking method. The size (hydrodynamic diameter ∼200 nm) and surface charge (zeta potential ∼ − 30 mV) of the CaANCs are both compatible with their application on skin. CaANCs loaded with a fluorescent label were stable in model hydrophilic galenic forms under different storage conditions. Curcumin was encapsulated in CaANCs with an efficiency of ∼95%, fully retaining its antioxidant activity. The application of the curcumin-loaded CaANCs on excised human skin led to a significant accumulation of the active molecules in the upper layers of the skin, asserting the potential of these nanocarriers in active pharmaceutical and cosmetic ingredients topical delivery. (paper)

  7. Social dialogue and social conflict as a topical factors of social transformations

    Directory of Open Access Journals (Sweden)

    I. Z. Derzhko

    2015-01-01

    Full Text Available The critical state of society can be measured by a system of interrelated indicators - economic, technologi­cal, political, cultural, ethnic and demographic. However, it is no exaggeration to state that they originally focused on the social aspects of life people lead to an integrated life crisis at a time of social transformations. There is no universal model of social dialogue; it is a means of improving productivity and competitiveness. Social dialogue - not only a form of crisis management, sometimes governments are turning to social part­ners only in case of economic crisis, seeking their support in taking unpopular measures. This approach is fundamentally wrong, because the dialogue is based on mutual trust and confidence, cooperation achieved over the years. That social dialogue should be used not only in adverse but also in favorable socio-economic circumstances. Opposition, competition, conflict, alternative, dissent is not only inevitable characteristics of a complex human world, but necessary factors that discourage stagnation, stagnation of society, the condi­tions of its constant renewal and development. Clarification of the nature and essence of social conflict as a specific manifestation of the contradictions of social relations requires consideration of a number of interre­© І.З. Держко, 2015 lated factors. First of all, we should take into account the fact that modern society is the very course of change in scientific thinking, social structure, is drawn into a new state, which is accompanied by adapting social transformation. That is why these problems require analysis of the conditions of its emergence, development methods and tools for forecasting and warning deviation from social norms. Social process includes ways of interaction between state and society, institutions and groups, political system and social environment, government and citizens. Social dialogue is one way of interaction between state and society

  8. Testing of an Echelle Spectrometer as a LIBS Detector at Sandia; TOPICAL

    International Nuclear Information System (INIS)

    David P. Baldwin; Daniel S. Zamzow; David K. Ottesen; Howard A. Johnsen

    2001-01-01

    Some useful information has been obtained regarding the potential use of the echelle spectrometer system for Laser-Induced Breakdown Spectroscopy (LIBS) monitoring applications, despite the AOTF-computer operational problems during the Sandia site-test. Currently, the use of the echelle spectrometer with the LIBS system is not suitable for trace-level analyte detection. This is due, in part, to the lower light throughput of the echelle spectrometer system compared to the SpectraPro-275. The low duty cycle of the LIBS system, which results from the use of a low-repetition-rate (but low-cost and portable) laser, also limits the detection sensitivity achievable using a high-resolution spectrometer. At high analyte concentrations, the echelle spectrometer is able to resolve spectral interferences including the Cd-As line pair at 228.8-nm and other LIBS emission features not resolved using the SpectraPro-275. A definite positive result obtained is the determination that at the high resolution of the echelle spectrometer, time-gating of the CCD detector is not necessary to discriminate analyte spectral signals from the LIBS background emission. The cost of the gated CCD and associated electronics is a significant portion of the cost of the Sandia LIBS system. Incorporation of a low-cost version of the echelle spectrometer for process monitoring applications not requiring trace-level detection could make LIBS a more viable technique where cost is a limiting factor. We hope to have the opportunity to perform additional collaborative work using the AOTF-echelle spectrometer for on-line LIBS monitoring applications, in order to demonstrate the advantage of rapid line-switching (using the AOTF) and simultaneous detection of multiple emission features across the spectral range of the echelle

  9. Development of backfill material as an engineered barrier in the waste package system. Interim topical report

    International Nuclear Information System (INIS)

    Wheelwright, E.J.; Hodges, F.N.; Bray, L.A.; Westsik, J.H. Jr.; Lester, D.H.; Nakai, T.L.; Spaeth, M.E.; Stula, R.T.

    1981-09-01

    A backfill barrier, emplaced between the containerized waste and the host rock, can both protect the other engineered barriers and act as a primary barrier to the release of radionuclides from the waste package. Attributes that a backfill should provide in order to carry out its required function have been identified. Primary attributes are those that have a direct effect upon the release and transport of radionuclides from the waste package. Supportive attributes do not directly affect radionuclide release but are necessary to support the primary attributes. The primary attributes, in order of importance, are: minimize (retard or exclude) the migration of ground water between the host rock and the waste canister system; retard the migration of selected chemical species (corrosive species and radionuclides) in the ground water; control the Eh and pH of the ground water within the waste-package environment. The supportive attributes are: self-seal any cracks or discontinuities in the backfill or interfacing host geology; retain performance properties at all repository temperatures; retain peformance properties during and after receiving repository levels of gamma radiation; conduct heat from the canister system to the host geology; retain mechanical properties and provide resistance to applied mechanical forces; retain morphological stability and compatibility with structural barriers and with the host geology for required period of time. Screening and selection of candidate backfill materials has resulted in a preliminary list of materials for testing. Primary emphasis has been placed on sodium and calcium bentonites and zeolites used in conjunction with quartz sand or crushed host rock. Preliminary laboratory studies have concentrated on permeability, sorption, swelling pressure, and compaction properties of candidate backfill materials

  10. Topical simvastatin gel as a novel therapeutic modality for palatal donor site wound healing following free gingival graft procedure.

    Science.gov (United States)

    Madi, Marwa; Kassem, Abeer

    2018-04-01

    Autogenous soft-tissue grafting is a commonly used procedure nowadays in dentistry. However, the prolonged healing time needed for the donor site leads to increase the patient's pain and discomfort. Statin has been observed to be beneficial in reducing bacterial burden, improving epithelization and wound healing. The aim of this study was to evaluate intra-oral topical application of simvastatin/chitosan gel (10 mg/mL) over the palatal donor site following free gingival graft (FGG) procedure. Subjects indicated for FGG procedure were divided into four groups. Group I: Simvastatin suspension (S), group II: simvastatin/chitosan gel (SC), group III: chitosan gel (C), group IV: petroleum gel (P). Treatment was applied three times/day for the following 7 days. Wound healing was evaluated at day 3, 7 and 14 post-surgery. A visual analogue scale (VAS) was used to measure the experienced discomfort at 1, 3, 5, 7 and 14 days. Statistical significant reduction in wound-healing scores was observed after 3 and 7 days for group II compared to other groups (p  = .015). A significant reduction was also observed in VAS score for group II compared to other groups at day 1, 3, 5 and 7. Topical application of S/C gel could be used as a novel therapeutic modality that improved healing and reduced pain in the palatal donor site following FGG procedure.

  11. Effect of undecylenic acid as a topical microbicide against genital herpes infection in mice and guinea pigs.

    Science.gov (United States)

    Bourne, N; Ireland, J; Stanberry, L R; Bernstein, D I

    1999-01-01

    There is increasing interest in the use of topical microbicides to help prevent the spread of sexually transmitted diseases (STD). Undecylenic acid (UA), a monosaturated fatty acid, is the active ingredient in a number of over-the-counter (OTC) antifungal spray powders, that also exhibits in vitro antibacterial and antiviral activity, including herpes simplex virus (HSV) activity. We, therefore, evaluated UA as a topical microbicide against genital HSV infection using the murine and guinea pig models of genital herpes. Mice were administered a 20% solution of UA in polyethylene glycol (PEG) vehicle, vehicle alone or phosphate buffered saline (PBS) intravaginally immediately prior to vaginal challenge with HSV-2. Pre-treatment with UA decreased the number of mice that became infected (P < 0.001 vs. PBS or vehicle control), developed symptoms (P <0.001) or died (P <0.001). However, when treatment was extended to either 5 min prior to or after viral inoculation, protection was lost. Similar findings were found using the guinea pig model, where UA treatment completely prevented HSV-2 vaginal infection when given immediately prior to HSV-2 inoculation (P<0.001 vs. PBS or vehicle control). Thus, UA, an approved OTC medication, provided significant protection against HSV disease and infection only when applied immediately before viral inoculation, indicating that better formulations were needed to extend the duration of protection.

  12. Exploring the Abyss. The Financial Crisis of 2008 ff. as a Central Topic of Problem-Centered Social Science Education

    Directory of Open Access Journals (Sweden)

    Thorsten Hippe

    2010-07-01

    Full Text Available The financial crisis of 2008 ff. and financial crises in general should be a central topic of social science education because these crises are a recurrent and therefore structural feature of modern capitalism which has severe consequences for citizens’ quality of life. Hence, the citizenry should know how to prevent such developments which endanger its well-being in a massive way. Therefore, learners should understand the relationship between the quality of people’s everyday lives and those economic institutions and political decisions which have led to the current mess. They should be enabled to critically evaluate the current misregulation of the financial sector and the economy in order to identify possible policy measures to prevent or at least to mitigate future crises. By educating (young citizens in this way, the (future general public can – as a necessary counterweight to the lobbyism of the finance industry – exert more prudent political pressure which gives politicians a greater incentive to regulate the financial sector and the economy in a manner which is beneficial for the vast majority of the people instead of for a small elite. Two core concepts of the social sciences can be used to make the roots of the seemingly complex topic more understandable for learners: liability and inequality.

  13. Mathematical people profiles and interviews

    CERN Document Server

    Albers, Donald

    2008-01-01

    This unique collection contains extensive and in-depth interviews with mathematicians who have shaped the field of mathematics in the twentieth century. Collected by two mathematicians respected in the community for their skill in communicating mathematical topics to a broader audience, the book is also rich with photographs and includes an introduction by Philip J. Davis.

  14. Ian Stevenson: An Omega Interview.

    Science.gov (United States)

    Kastenbaum, Robert

    1994-01-01

    Presents interview with Professor of Psychiatry and Director, Division of Personality Studies, in Department of Psychiatric Medicine at University of Virginia (Charlottesville). Discusses one controversial topic in area of death studies, cases suggestive of reincarnation. Describes first case he investigated, method of inquiry used to investigate…

  15. Syntacticized topics in Kurmuk

    DEFF Research Database (Denmark)

    Andersen, Torben

    2015-01-01

    This article argues that Kurmuk, a little-described Western Nilotic language, is characterized by a syntacticized topic whose grammatical relation is variable. In this language, declarative clauses have as topic an obligatory preverbal NP which is either a subject, an object or an adjunct. The gr...

  16. Technology as system innovation: a key informant interview study of the application of the diffusion of innovation model to telecare.

    Science.gov (United States)

    Sugarhood, Paul; Wherton, Joseph; Procter, Rob; Hinder, Sue; Greenhalgh, Trisha

    2014-01-01

    To identify and explore factors that influence adoption, implementation and continued use of telecare technologies. As part of the Assistive Technologies for Healthy Living in Elders: Needs Assessment by Ethnography (ATHENE) project, 16 semi-structured interviews were conducted with key participants from organisations involved in developing and providing telecare technologies and services. Data were analysed thematically, using a conceptual model of diffusion of innovations. Participants identified numerous interacting factors that facilitated or hindered adoption and use. As predicted by the model, these related variously to the technology, individual adopters, the process of social influence, the innovativeness and readiness of organisations, implementation and routinisation processes following initial adoption, and the nature and strength of linkages between these elements. Key issues included (i) the complexity and uniqueness of the "user system", (ii) the ongoing work needed to support telecare use beyond initial adoption, and (iii) the relatively weak links that typically exist between users of telecare technologies and the organisations who design and distribute them. Telecare is not merely a technology but a complex innovation requiring input from, and coordination between, people and organisations. To promote adoption and use, these contextual factors must be specified, understood and addressed.

  17. Topic modelling in the information warfare domain

    CSIR Research Space (South Africa)

    De Waal, A

    2013-11-01

    Full Text Available In this paper the authors provide context to Topic Modelling as an Information Warfare technique. Topic modelling is a technique that discovers latent topics in unstructured and unlabelled collection of documents. The topic structure can be searched...

  18. [What factors aid in the recruitment of general practice as a career? An enquiry by interview of general practitioners].

    Science.gov (United States)

    Natanzon, Iris; Ose, D; Szecsenyi, J; Joos, S

    2010-05-01

    In some parts of Germany there is already a lack of general practitioners (GPs). The reasons for this lack are complex. On the one hand there is an increasing demand for GPs as a result to demographic changes and an increase in the number of chronic diseases. On the other hand fewer medical students decide to become a general practitioner. The aim of this study was to explore, from the perspective of GPs, factors influencing the choice of general practice as a career. Also analysed is the extent to which those factors influence medical students in their carrier choice. 16 GPs were interviewed. Qualitative content analysis according to Mayring has been assisted by the Atlas.ti software program. GPs thought that the occupational orientation of medical students would be strongly dependent on the attractiveness of their future profession. Factors affecting the day-to-day work of general practice and may deterring the carrier choice of students were: poor working and general conditions leading to an increasing dissatisfaction among GPs; decreasing prestige of GPs caused by changed personal and occupational values and attitudes within the society; as well as poor representation and image of general practice as a discipline within the medical curriculum. Various approaches aimed at different target groups can be derived from these identified factors: the government providing general and occupational conditions that would relieve GPs of excessive bureaucracy; universities and medical associations meeting the challenge by improving undergraduate and postgraduate education in general practice; and GPs themselves giving a more self-confident presentation of general practice. Georg Thieme Verlag KG Stuttgart * New York.

  19. Histatin 5-spermidine conjugates have enhanced fungicidal activity and efficacy as a topical therapeutic for oral candidiasis.

    Science.gov (United States)

    Tati, Swetha; Li, Rui; Puri, Sumant; Kumar, Rohitashw; Davidow, Peter; Edgerton, Mira

    2014-01-01

    Oropharyngeal candidiasis (OPC) is caused by the opportunistic fungi Candida albicans and is prevalent in immunocompromised patients, individuals with dry mouth, or patients with prolonged antibiotic therapies that reduce oral commensal bacteria. Human salivary histatins, including histatin 5 (Hst 5), are small cationic proteins that are the major source of fungicidal activity of saliva. However, Hsts are rapidly degraded in vivo, limiting their usefulness as therapeutic agents despite their lack of toxicity. We constructed a conjugate peptide using spermidine (Spd) linked to the active fragment of Hst 5 (Hst 54-15), based upon our findings that C. albicans spermidine transporters are required for Hst 5 uptake and fungicidal activity. We found that Hst 54-15-Spd was significantly more effective in killing C. albicans and Candida glabrata than Hst 5 alone in both planktonic and biofilm growth and that Hst 54-15-Spd retained high activity in both serum and saliva. Hst 54-15-Spd was not bactericidal against streptococcal oral commensal bacteria and had no hemolytic activity. We tested the effectiveness of Hst 54-15-Spd in vivo by topical application to tongue surfaces of immunocompromised mice with OPC. Mice treated with Hst 54-15-Spd had significant clearance of candidal tongue lesions macroscopically, which was confirmed by a 3- to 5-log fold reduction of C. albicans colonies recovered from tongue tissues. Hst 54-15-Spd conjugates are a new class of peptide-based drugs with high selectivity for fungi and potential as topical therapeutic agents for oral candidiasis.

  20. Preparation of a mixed-matrix hydrogel of vorinostat for topical administration on the rats as experimental model.

    Science.gov (United States)

    Dai, Wenwen; Wang, Chenhui; Yu, Changhui; Yao, Ju; Sun, Fengying; Teng, Lesheng; Li, Youxin

    2015-10-12

    Oral vorinostat has the remarkable curative effect on aggravated and recurrent cutaneous T-cell lymphoma (CTCL), but is accompanied by serious adverse effects. Therefore, oral vorinostat is not applicable to the treatment of early stage CTCL. The aim of this study is to develop a novel vorinostat formulation which is effective for early stage CTCL and free of the serious adverse effects. A mixed-matrix hydrogel of vorinostat was prepared and characterized as a potential topical skin delivery system. Moisture retention, swelling behavior, viscosity, real-time morphology and differential scanning calorimeter analysis (DSC) of hydrogel were evaluated to select the solvent, matrix and humectant. The optimal HPMC/HPC ratio, pH, additive, dose and drug loading of vorinostat hydrogel were determined by evaluating the cumulative vorinostat amount of skin retention and transdermal amount of vorinostat through the skin in vitro. The optimal hydrogel presented a low transdermal amount of vorinostat through the skin, suggesting that the hydrogel reduced the amount of vorinostat that was absorbed in the systemic circulation. More importantly, in vivo percutaneous permeation experiments were also performed to evaluate the permeation behavior of vorinostat into the skin. The topical application with a much lower dose showed higher AUC (the cumulative vorinostat amount of skin retention) than oral application and the hydrogel achieved a sustained permeation of vorinostat in the skin for 24h in vivo. It indicated that a higher relative bioavailability for hydrogel was achieved compared with oral vorinostat. Moreover, there was no damage, inflammation or cell swelling of the skin after administration. Thus, the mixed-matrix vorinostat hydrogel prepared in this study could deliver vorinostat into local skin more efficiently than oral administration. Copyright © 2015 Elsevier B.V. All rights reserved.

  1. A Four-Step Model for Teaching Selection Interviewing Skills

    Science.gov (United States)

    Kleiman, Lawrence S.; Benek-Rivera, Joan

    2010-01-01

    The topic of selection interviewing lends itself well to experience-based teaching methods. Instructors often teach this topic by using a two-step process. The first step consists of lecturing students on the basic principles of effective interviewing. During the second step, students apply these principles by role-playing mock interviews with…

  2. Motivational Interviewing as an intervention to increase adolescent self-efficacy and promote weight loss: Methodology and design

    Directory of Open Access Journals (Sweden)

    Morrongiello Barbara

    2011-06-01

    Full Text Available Abstract Background Childhood obesity is associated with serious physiological and psychological consequences including type 2 diabetes, higher rates of depression and low self-esteem. With the population of overweight and obese youth increasing, appropriate interventions are needed that speak to the issue of readiness to change and motivation to maintain adherence to healthy behavior changes. Motivational Interviewing (MI is a method of therapy found to resolve ambivalence, enhance intrinsic motivation and promote confidence in a person's ability to make behavior changes. While MI has shown promise in the adult obesity literature as effecting positive lifestyle change, little is known about the effectiveness of MI with overweight and obese youth. This study aims to: 1 demonstrate that MI is an effective intervention for increasing a person's self-efficacy; 2 demonstrate that exposure to MI will facilitate healthy behavior changes; 3 explore psychological changes related to participation in MI and 4 compare physiological and anthropometric outcomes before and after intervention. Methods/Design The current investigation is a prospective study conducted with ongoing participants who regularly attend an outpatient pediatric care center for weight-loss. Overweight youth (BMI > 85th %ile between the ages of 10 and 18 who meet eligibility criteria will be recruited. Participants will be randomly assigned to a control group (social skills training or a treatment group (MI. Participants will meet with the therapist for approximately 30 minutes prior to seeing the dietician, over the course of 6 months. Participants will also undergo a full day assessment at the beginning and end of psychology intervention to evaluate body fat, and metabolic risk (screening for diabetes, high cholesterol, high blood pressure and fitness level. The paper and pencil portions of the assessments as well as the clinical testing will occur at baseline and at the conclusion of

  3. Providers as weight coaches: using practice guides and motivational interview to treat obesity in the pediatric office.

    Science.gov (United States)

    Tripp, Sandy Blizzard; Perry, Joan Templeton; Romney, Sharon; Blood-Siegfried, Jane

    2011-10-01

    Motivational interview techniques combined with an evidence-based guideline provide valuable tools for the treatment of childhood obesity. The National Association of Pediatric Nurse Practitioners' Healthy Eating and Activity Together guidelines were adopted in a rural pediatric office. After a 6-month pilot, effectiveness of treatment was evaluated with a retrospective chart review. The results suggest that children were motivated for healthy lifestyle changes but had difficulty maintaining motivation and compliance with healthy change choices after 1-2 months; however, with consistent use of motivational interviewing techniques combined with diet and exercise counseling, there was a trend toward lowered body mass index and waist measurements. Copyright © 2011 Elsevier Inc. All rights reserved.

  4. Motivational Interviewing as an intervention to increase adolescent self-efficacy and promote weight loss: Methodology and design

    OpenAIRE

    Morrongiello Barbara; Dettmer Elizabeth; Walpole Beverly; McCrindle Brian; Hamilton Jill

    2011-01-01

    Abstract Background Childhood obesity is associated with serious physiological and psychological consequences including type 2 diabetes, higher rates of depression and low self-esteem. With the population of overweight and obese youth increasing, appropriate interventions are needed that speak to the issue of readiness to change and motivation to maintain adherence to healthy behavior changes. Motivational Interviewing (MI) is a method of therapy found to resolve ambivalence, enhance intrinsi...

  5. Water-filtered infrared-A (wIRA can act as a penetration enhancer for topically applied substances

    Directory of Open Access Journals (Sweden)

    Sterry, Wolfram

    2008-07-01

    increased penetration depth compared to the non-irradiated skin (mode A: The ratio of the amount of the dye in the deeper (second 10% of the stratum corneum to the amount of the dye in the upper 10% of the stratum corneum showed medians and interquartile ranges for mode A of 0.017 (0.007/0.050, for mode B of 0.084 (0.021/0.106, for mode C of 0.104 (0.069/0.192 (difference between modes: p=0.0112, significant; comparison mode A with mode C: p<0.01, significant. In contrast to fluorescein, the lipophilic curcumin showed no differences in the penetration kinetics, in reference to whether the skin was irradiated with wIRA or not. These effects were confirmed by laser scanning microscopy. Water-filtered infrared-A irradiation increased the hydration of the stratum corneum: transepidermal water loss rose from approximately 8.8 g m-2 h-1 before wIRA irradiation to 14.2 g m-2 h-1 after wIRA irradiation and skin hydration rose from 67 to 87 relative units. Skin surface temperature increased from 32.8°C before wIRA to 36.4°C after wIRA irradiation. Discussion: The better penetration of the hydrophilic dye fluorescein after or during skin irradiation (modes B and C can be explained by increased hydration of the stratum corneum by irradiation with wIRA. Conclusions: As most topically applied substances for the treatment of patients are mainly hydrophilic, wIRA can be used to improve the penetration of substances before or after application of substances – in the first case even of thermolabile substances – with a broad clinical relevance as a contact free alternative to an occlusive dressing.

  6. Women's experiences of using vaginal trainers (dilators) to treat vaginal penetration difficulties diagnosed as vaginismus: a qualitative interview study.

    Science.gov (United States)

    Macey, Kat; Gregory, Angela; Nunns, David; das Nair, Roshan

    2015-06-20

    Recent research has highlighted controversies in the conceptualisation, diagnosis and treatment of vaginismus. Vaginal trainers are currently the most widely used treatment. Critiques have highlighted concerns that the evidence-base of its effectiveness is limited, with controlled trials reporting disappointing results, and its prescription promotes 'performance-based' sexuality which may be detrimental. Despite this, little has been done to seek women's views about their treatment. This study set out to explore women's experiences of vaginismus treatment with vaginal trainers, and to use their voices to propose guidelines for improving treatment. 13 women who had used vaginal trainers for vaginal penetration difficulties diagnosed as vaginismus were recruited through a specialist clinic, university campuses, and online forums. The women took part in semi-structured individual interviews (face-to-face/telephone/Skype), which were audio-recorded, transcribed verbatim and analysed using Thematic Analysis. Four superordinate themes were elicited and used to draft 'better treatment' guidelines. Themes were: (1) Lack of knowledge, (2) Invalidation of suffering by professionals, (3) Difficult journey, and (4) Making the journey easier. This paper describes themes (3) and (4). Difficult Journey describes the long and arduous 'Journey into treatment', including difficulties asking for help, undergoing physical investigations and negotiating 'the system' of medical referrals. It also describes the sometimes demoralising process of 'being in treatment', which includes emotional and practical demands of treatment. Making the journey easier highlights the importance of and limits to 'partner support'. 'Professional support' comprises personal qualities of professionals/therapeutic relationship, the value of specialist skills and knowledge and the need for facilitating couple communication about vaginismus. 'Peer support/helping each other' describes the importance of

  7. A case of topical opioid-induced delirium mistaken as behavioural and psychological symptoms of dementia in demented state.

    Science.gov (United States)

    Ito, Go; Kanemoto, Kousuke

    2013-06-01

    In Japan, indications for opioid analgesics, once exclusively used as pain killers for patients suffering from malignant cancer, have been expanded for a wide range of pain. Herein we report a patient with opioid-induced delirium associated with the administration of buprenorphine patches that was well below the indicated therapeutic range limit. An 82-year-old woman was referred to us from an orthopaedic practitioner for uncontrollable behavioural problems apparently caused by the beginning of dementia; the patient had gradually developed disorientation, visual hallucinations, and delusions. Laboratory and imaging findings excluded common causes of delirium including Alzheimer's disease and diffuse Lewy body disease. Detailed questioning revealed that the patient's confused state appeared following a buprenorphine patch dose increase and subsequently disappeared after administration was stopped. Delirium has not been reported as a side-effect in clinical trials of buprenorphine patches. However, our findings in this case show that even topical opioids can precipitate the development of a delirious state in elderly patients. © 2013 The Authors. Psychogeriatrics © 2013 Japanese Psychogeriatric Society.

  8. Learning Pathways, Learning Progression--The Process Matters: An Interview with Prof. Hans Niedderer about His Work as a Physics Education Researcher in Germany

    Science.gov (United States)

    Kulgemeyer, Christoph

    2014-01-01

    Hans Niedderer has contributed a lot to German physics education research. His work includes quantitative and qualitative studies about topics like the learning of physics concepts or the history and philosophy of science in science teaching, he has worked on theoretical issues as well as on textbooks. But it is not only his work that is…

  9. Interview as an Act of Seduction: Analysing Problems I Have Met during My Fieldwork on the Camino de Santiago and in Glastonbury

    Directory of Open Access Journals (Sweden)

    Tiina Sepp

    2012-12-01

    Full Text Available In this article I am going to analyse my experiences of fieldwork and discuss the role of the researcher in the process of data collection. I will approach problems arising during folkloristic fieldwork and the focus will be on researching belief narrative in personal experience stories. A lot has been written about fieldwork and in this article I am going to add my thoughts on topics that have already been discussed in self-critical reflexive style by several scholars: the different roles of the researcher and the problematic interactional relationship between researcher and informant; power relationships in an interview situation; combining emic and etic perspectives in researching; being ambivalent about which reality we really belong to. I am also going to raise some issues that have to date not been discussed much: the effect of the researcher’s gender on the process of fieldwork; stigmatisation of the supernatural; using the researcher’s own memorates to elicit belief statements from his or her informants; dealing with ‘difficult’ informants. Against the background of the above-mentioned topics lies the liminality of the researcher – while in the field we are in a state of liminality that Victor Turner described when talking about pilgrims and neophytes.Apart from discussing fieldwork-related problems, I am also going to describe some expressions of vernacular religion and contemporary spirituality on the Camino de Santiago and in Glastonbury. 

  10. Interview as an Act of Seduction: Analysing Problems I Have Met during My Fieldwork on the Camino de Santiago and in Glastonbury

    Directory of Open Access Journals (Sweden)

    Tiina Sepp

    2013-01-01

    Full Text Available In this article I am going to analyse my experiences of fieldwork and discuss the role of the researcher in the process of data collection. I will approach problems arising during folkloristic fieldwork and the focus will be on researching belief narrative in personal experience stories. A lot has been written about fieldwork and in this article I am going to add my thoughts on topics that have already been discussed in self-critical reflexive style by several scholars: the different roles of the researcher and the problematic interactional relationship between researcher and informant; power relationships in an interview situation; combining emic and etic perspectives in researching; being ambivalent about which reality we really belong to. I am also going to raise some issues that have to date not been discussed much: the effect of the researcher’s gender on the process of fieldwork; stigmatisation of the supernatural; using the researcher’s own memorates to elicit belief statements from his or her informants; dealing with ‘difficult’ informants. Against the background of the above-mentioned topics lies the liminality of the researcher – while in the field we are in a state of liminality that Victor Turner described when talking about pilgrims and neophytes. Apart from discussing fieldwork-related problems, I am also going to describe some expressions of vernacular religion and contemporary spirituality on the Camino de Santiago and in Glastonbury.

  11. Second Language Vocabulary Learning and Teaching: Still a Hot Topic

    Science.gov (United States)

    Larrotta, Clarena

    2011-01-01

    For many reasons second language vocabulary learning and teaching continues to be a topic of interest for learners, instructors, and researchers. This article describes the implementation of personal glossaries in a community program offering English as second language classes to Latina/o Spanish speaking adults. Field notes, interviews, and…

  12. 'I wish someone watched me interview:' medical student insight into observation and feedback as a method for teaching communication skills during the clinical years.

    Science.gov (United States)

    Schopper, Heather; Rosenbaum, Marcy; Axelson, Rick

    2016-11-09

    Experts suggest observation and feedback is a useful tool for teaching and evaluating medical student communication skills during the clinical years. Failing to do this effectively risks contributing to deterioration of students' communication skills during the very educational period in which they are most important. While educators have been queried about their thoughts on this issue, little is known about what this process is like for learners and if they feel they get educational value from being observed. This study explored student perspectives regarding their experiences with clinical observation and feedback on communication skills. A total of 125 senior medical students at a U.S. medical school were interviewed about their experiences with observation and feedback. Thematic analysis of interview data identified common themes among student responses. The majority of students reported rarely being observed interviewing, and they reported receiving feedback even less frequently. Students valued having communication skills observed and became more comfortable with observation the more it occurred. Student-identified challenges included supervisor time constraints and grading based on observation. Most feedback focused on information gathering and was commonly delayed until well after the observed encounter. Eliciting students' perspectives on the effect of observation and feedback on the development of their communication skills is a unique way to look at this topic, and brings to light many student-identified obstacles and opportunities to maximize the educational value of observation and feedback for teaching communication, including increasing the number of observations, disassociating observation from numerically scored evaluation, training faculty to give meaningful feedback, and timing the observation/feedback earlier in clerkships.

  13. Clinical efficacy and IL-17 targeting mechanism of Indigo naturalis as a topical agent in moderate psoriasis.

    Science.gov (United States)

    Cheng, Hui-Man; Wu, Yang-Chang; Wang, Qingmin; Song, Michael; Wu, Jackson; Chen, Dion; Li, Katherine; Wadman, Eric; Kao, Shung-Te; Li, Tsai-Chung; Leon, Francisco; Hayden, Karen; Brodmerkel, Carrie; Chris Huang, C

    2017-09-02

    Indigo naturalis is a Traditional Chinese Medicine (TCM) ingredient long-recognized as a therapy for several inflammatory conditions, including psoriasis. However, its mechanism is unknown due to lack of knowledge about the responsible chemical entity. We took a different approach to this challenge by investigating the molecular profile of Indigo naturalis treatment and impacted pathways. A randomized, double-blind, placebo-controlled clinical study was conducted using Indigo naturalis as topical monotherapy to treat moderate plaque psoriasis in a Chinese cohort (n = 24). Patients were treated with Indigo naturalis ointment (n = 16) or matched placebo (n = 8) twice daily for 8 weeks, with 1 week of follow-up. At week 8, significant improvements in Psoriasis Area and Severity Index (PASI) scores from baseline were observed in Indigo naturalis-treated patients (56.3% had 75% improvement [PASI 75] response) compared with placebo (0.0%). A gene expression signature of moderate psoriasis was established from baseline skin biopsies, which included the up-regulation of the interleukin (IL)-17 pathway as a key component; Indigo naturalis treatment resulted in most of these signature genes returning toward normal, including down-regulation of the IL-17 pathway. Using an in vitro keratinocyte assay, an IL-17-inhibitory effect was observed for tryptanthrin, a component of Indigo naturalis. This study demonstrated the clinical efficacy of Indigo naturalis in moderate psoriasis, and exemplified a novel experimental medicine approach to understand TCM targeting mechanisms. NCT01901705 .

  14. Choline- versus imidazole-based ionic liquids as functional ingredients in topical delivery systems: cytotoxicity, solubility, and skin permeation studies.

    Science.gov (United States)

    Santos de Almeida, Tânia; Júlio, Ana; Saraiva, Nuno; Fernandes, Ana Sofia; Araújo, Maria Eduarda M; Baby, André Rolim; Rosado, Catarina; Mota, Joana Portugal

    2017-11-01

    Poor drug solubility represents a problem for the development of topical formulations. Since ionic liquids (ILs) can be placed in either lipophilic or hydrophilic solutions, they may be advantageous vehicles in such delivery systems. Nonetheless, it is vital to determine their usefulness when used at concentrations were cell viability is maintained, which was considered herein. Five different ILs were prepared-three imidazole-based ILs: [C2mim][Br], [C4mim][Br], and [C6mim][Br]; and two choline-based ILs: [Cho][Phe] and [Cho][Glu]. Their cytotoxicity in human keratinocytes (HaCat cells), their influence in drug solubility and in percutaneous permeation, using pig skin membranes, was evaluated. Caffeine and salicylic acid were used as model actives. Choline-based ILs proved to be more suitable as functional ingredients, since they showed higher impact on drug solubility and a lower cytotoxicity. The major solubility enhancement was observed for caffeine and further solubility studies were carried out with this active in several concentrations of the choline-based ILs (0.1; 0.2; 0.5; 1.0; 3.0 and 5.0%, w/w) at 25 °C and 32 °C. Solubility was greatly influenced by concentrations up to 0.5%. The choline-based ILs showed no significant impact on the skin permeation, for both actives. The size of the imidazole-based ILs alkyl chain enhances the caffeine solubility and permeation, but also the ILs cytotoxicity. Stable O/W emulsions and gels were prepared containing the less toxic choline-based ILs and caffeine. Our results indicate that the choline-based ILs were effective functional ingredients, since, when used at nontoxic concentrations, they allowed a higher drug loading, while maintaining the stability of the formulations.

  15. Interviewing media workers

    Directory of Open Access Journals (Sweden)

    Heike Graf

    2010-11-01

    Full Text Available The focus of this article is on the use of Niklas Luhmann’s systems theoretical approach in order to analyse interviews conducted with media workers concerning their experiences of ethnic diversity in newsrooms. Applying systems theory means constructing the interview as a social system and seeing the “data” as observations produced by the observer and not as representations of a reality. The first part of the article describes the interview methodology and the second part provides examples, from the current study, of how systems theory can be applied in order to analyse interviews. Using a difference-theoretical approach means looking at the distinctions the informants make when talking about their experiences. These main guiding distinctions can be summarised as immigrant background/competence as well as advantage/competence. Using the guiding distinction of inclusion/exclusion when interpreting the interviewees’ statements, the interdependencies of mechanisms of inclusion and exclusion in newsrooms related to ethnic background can be examined.

  16. Topical application of mitomycin-C as an adjuvant treatment to bronchoscopic procedures in post-intubation tracheal stenosis

    Directory of Open Access Journals (Sweden)

    F. Viveiros

    2013-11-01

    Full Text Available Introduction: Post-intubation tracheal stenosis (PITS continues to be challenging in terms of diagnosis, management and prevention. Recurrence is common because of excessive granulation tissue formation and an insidious process of scar contracture. Topical application of mitomycin-C (MMC as an adjuvant treatment for endoscopic management of stenosis has shown good results. The authors aimed to evaluate the results of MMC topical application following bronchoscopic dilatation as an adjuvant in PITS treatment. Methods: Retrospectively selected patients with PITS who had had rigid bronchoscopy (RB dilatation followed by MMC application as adjuvant to endoscopic treatment. MMC in a concentration of 0.4 mg/ml was applied with a cotton stiletto around the stenotic lesion and granulation tissue for 3 min. Results: Eleven patients with PITS, with a median initial tracheal stenosis of 75% of the lumen, underwent RB/MMC treatment. Mean MMC sessions performed/patient was 3.5, with good response and prolonged decrease in granulation tissue formation in 55% of cases, moderate in 18% and relapse in 27%. Mean stenosis improvement was 34%. Conclusions: Topical MMC application at 0.4 mg/ml concentration seems to be associated with good results as adjuvant in PITS management with decrease in granulation tissue and sustained improvement in lumen diameter. Resumo: Introdução: O diagnóstico, tratamento e prevenção da estenose traqueal pós-entubação (ETPE continua a ser um desafio. A recorrência é comum devido à formação excessiva de tecido de granulação e a um processo insidioso de cicatrização constritiva. A aplicação tópica de mitomicina-C (MMC tem mostrado bons resultados como tratamento adjuvante na manipulação endoscópica das estenoses traqueais. Os autores tiveram como objetivo avaliar os resultados da aplicação tópica de MMC, após dilatação broncoscópica, como tratamento adjuvante da ETPE. Métodos: Doentes com ETPE

  17. New Materialism: Interviews & Cartographies

    NARCIS (Netherlands)

    van der Tuin, I.; Dolphijn, R.

    2012-01-01

    This book is the first monograph on the theme of “new materialism,” an emerging trend in 21st century thought that has already left its mark in such fields as philosophy, cultural theory, feminism, science studies, and the arts. The first part of the book contains elaborate interviews with some of

  18. Interview with Louise Lonabocker

    Science.gov (United States)

    von Munkwitz-Smith, Jeffrey

    2015-01-01

    This issue of "College and University" marks a transition in the Editor-in-Chief Position, with the interview of Louise Lonabocker, who has served in this capacity for the past ten years. She has also served as President of AACRAO, and in both positions, Lonabocker has been a role model for many AACRAO leaders. Lonabocker describes the…

  19. Interview with Jessica Utts

    Science.gov (United States)

    Rossman, Allan; Utts, Jessica

    2014-01-01

    This article offers a transcript of author Allan Rossman's interview with Jessica Utts, Professor and Chair of Statistics at the University of California-Irvine. Utts is also a Fellow of the American Statistical Association and a recipient of a Founders Award from ASA. Additionally, she has been elected as President of ASA for the year 2016. The…

  20. Avaliação da sobrecarga do cuidador de crianças com paralisia cerebral através da escala Burden Interview Assessment of the caregiver burden of children with cerebral palsy using the Burden Interview scale

    Directory of Open Access Journals (Sweden)

    Ana Cristina Resende Camargos

    2009-03-01

    Full Text Available OBJETIVOS: avaliar fatores que influenciam na sobrecarga dos cuidadores de crianças com paralisia cerebral. MÉTODOS: foram entrevistados 56 cuidadores de crianças com paralisia cerebral com idade entre um e 15 anos. Para avaliar a sobrecarga dos cuidadores foi utilizada a escala Burden Interview e foram coletados dados sobre nível socioeconômico da família, gravidade do comprometimento motor, diagnóstico topográfico e idade das crianças com paralisia cerebral. Para análise dos dados foram utilizados os testes Mann-Whitney e Kruskal-Wallis. RESULTADOS: um menor nível socioeconômico da família (p=0,03 e uma menor gravidade do comprometimento motor (p=0,05 das crianças com paralisia cerebral foram associados com maior sobrecarga do cuidador. Não houve diferença significativa em relação ao diagnóstico topográfico (p=0,71 e à idade das crianças com paralisia cerebral (p=0,35. CONCLUSÕES: o conhecimento de fatores que influenciam a sobrecarga dos cuidadores de crianças com paralisia cerebral é mais um dado a ser agregado no planejamento de atenção e intervenção a esse público específico.OBJECTIVES: to evaluate factors that influence the caregiver burden of children with cerebral palsy. METHODS: 56 caregivers who worked with children with cerebral palsy aged between one and fifteen years old were evaluated. To evaluate the caregiver burden the Burden Interview scale was used, along with data on the social and economic circumstances of the children's families, the severity of motor impairment, topographic diagnosis and age of child. The Mann-Whitney and Kruskal-Wallis test were used for data analysis. RESULTS: poorer social and economic circumstances of the children's families (p=0.03 and a lower severity of motor impairment (p=0.05 in the child with cerebral palsy were associated to a heavier caregiver burden. There was no significant difference in the case of topographic diagnosis (p=0.71 and age of child with cerebral

  1. Evaluation of Novel Antimicrobial Peptides as Topical Anti-Infectives with Broad Spectrum Activity Against Combat-Related Bacterial and Fungal Wound Infections

    Science.gov (United States)

    2016-10-01

    absence of topical antibiotics, are immediately colonized by gram-positive skin flora, such as Staphylococcus aureus. Gram-negative bacteria such as...in a wound, as the dAMP is metabolized and/or diluted with tissue fluids, it will continue to be active. We are aware that the peptides will be

  2. Audio computer-assisted self interview compared to traditional interview in an HIV-related behavioral survey in Vietnam.

    Science.gov (United States)

    Le, Linh Cu; Vu, Lan T H

    2012-10-01

    Globally, population surveys on HIV/AIDS and other sensitive topics have been using audio computer-assisted self interview for many years. This interview technique, however, is still new to Vietnam and little is known about its application and impact in general population surveys. One plausible hypothesis is that residents of Vietnam interviewed using this technique may provide a higher response rate and be more willing to reveal their true behaviors than if interviewed with traditional methods. This study aims to compare audio computer-assisted self interview with traditional face-to-face personal interview and self-administered interview with regard to rates of refusal and affirmative responses to questions on sensitive topics related to HIV/AIDS. In June 2010, a randomized study was conducted in three cities (Ha Noi, Da Nan and Can Tho), using a sample of 4049 residents aged 15 to 49 years. Respondents were randomly assigned to one of three interviewing methods: audio computer-assisted self interview, personal face-to-face interview, and self-administered paper interview. Instead of providing answers directly to interviewer questions as with traditional methods, audio computer-assisted self-interview respondents read the questions displayed on a laptop screen, while listening to the questions through audio headphones, then entered responses using a laptop keyboard. A MySQL database was used for data management and SPSS statistical package version 18 used for data analysis with bivariate and multivariate statistical techniques. Rates of high risk behaviors and mean values of continuous variables were compared for the three data collection methods. Audio computer-assisted self interview showed advantages over comparison techniques, achieving lower refusal rates and reporting higher prevalence of some sensitive and risk behaviors (perhaps indication of more truthful answers). Premarital sex was reported by 20.4% in the audio computer-assisted self-interview survey

  3. An Exploratory Study of the Concept Map as a Tool To Facilitate the Externalization of Students' Understandings about Global Atmospheric Change in the Interview Setting.

    Science.gov (United States)

    Rye, James A.; Rubba, Peter A.

    The primary purpose of this study was to investigate the effectiveness of two different types of post-instruction concept interviews: one that did and one that did not embed a concept mapping process as means of eliciting students' post-instruction conceptual understandings about the nature of, source of, and problems caused by chlorofluorocarbons…

  4. The "What Is a System" Reflection Interview as a Knowledge Integration Activity for High School Students' Understanding of Complex Systems in Human Biology

    Science.gov (United States)

    Tripto, Jaklin; Ben-Zvi Assaraf, Orit; Snapir, Zohar; Amit, Miriam

    2016-01-01

    This study examined the reflection interview as a tool for assessing and facilitating the use of "systems language" amongst 11th grade students who have recently completed their first year of high school biology. Eighty-three students composed two concept maps in the 10th grade--one at the beginning of the school year and one at its end.…

  5. Solid Lipid Nanoparticles Loaded with Retinoic Acid and Lauric Acid as an Alternative for Topical Treatment of Acne Vulgaris.

    Science.gov (United States)

    Silva, Elton Luiz; Carneiro, Guilherme; De Araújo, Lidiane Advíncula; Trindade, Mariana de Jesus Vaz; Yoshida, Maria Irene; Oréfice, Rodrigo Lambert; Farias, Luis de Macêdo; De Carvalho, Maria Auxiliadora Roque; Dos Santos, Simone Gonçalves; Goulart, Gisele Assis Castro; Alves, Ricardo José; Ferreira, Lucas Antônio Miranda

    2015-01-01

    Topical therapy is the first choice for the treatment of mild to moderate acne and all-trans retinoic acid is one of the most used drugs. The combination of retinoids and antimicrobials is an innovative approach for acne therapy. Recently, lauric acid, a saturated fatty acid, has shown strong antimicrobial activity against Propionibacterium acnes. However, topical application of retinoic acid is followed by high incidence of side-effects, including erythema and irritation. Solid lipid nanoparticles represent an alternative to overcome these side-effects. This work aims to develop solid lipid nanoparticles loaded with retinoic acid and lauric acid and evaluate their antibacterial activity. The influence of lipophilic stearylamine on the characteristics of solid lipid nanoparticles was investigated. Solid lipid nanoparticles were characterized for size, zeta potential, encapsulation efficiency, differential scanning calorimetry and X-ray diffraction. The in vitro inhibitory activity of retinoic acid-lauric acid-loaded solid lipid nanoparticles was evaluated against Propionibacterium acnes, Staphylococcus aureus and Staphylococcus epidermidis. High encapsulation efficiency was obtained at initial time (94 ± 7% and 100 ± 4% for retinoic acid and lauric acid, respectively) and it was demonstrated that lauric acid-loaded-solid lipid nanoparticles provided the incorporation of retinoic acid. However, the presence of stearylamine is necessary to ensure stability of encapsulation. Moreover, retinoic acid-lauric acid-loaded solid lipid nanoparticles showed growth inhibitory activity against Staphylococcus epidermidis, Propionibacterium acnes and Staphylococcus aureus, representing an interesting alternative for the topical therapy of acne vulgaris.

  6. Doxepin Topical

    Science.gov (United States)

    ... have or have ever had glaucoma, benign prostatic hypertrophy (enlargement of the prostate), or urinary retention (inability ... any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each ...

  7. Cryotherapy and Topical Minocycline as Adjunctive Measures to Control Pain After Third Molar Surgery: An Exploratory Study

    Science.gov (United States)

    Gelesko, Savannah; Long, Leann; Faulk, Jan; Phillips, Ceib; Dicus, Carolyn; White, Raymond P.

    2013-01-01

    Purpose To assess the impact of cryotherapy or topical minocycline on patients’ perceptions of recovery from pain after third molar surgery in an exploratory comparative-effectiveness study. Patients and Methods Subjects aged at least 14 years who were having all 4 third molars removed were enrolled in 3 separate institutional review board–approved studies. Study groups included subjects treated with a passively applied cold wrap for 24 hours postoperatively, subjects treated with topical minocycline during surgery, and subjects enrolled in a nonconcurrent comparison group who had received neither topical minocycline nor directed cryotherapy. Third molar surgery was performed in all cases by trained surgeons using the same protocol. An exact Kruskal-Wallis test was used to compare the distributions of the worst and average pain scores and a Fisher exact test to compare verbal responses from Gracely pain scales among the 3 groups for postsurgical days (PSDs) 1 to 3. Results This study comprised 51 cryotherapy subjects (2005–2009), 63 minocycline subjects (2003–2004), and 92 comparison-group subjects (2002–2006) who were treated at academic centers and in community practices across the United States (N = 206). Demographic descriptors were similar among all groups. For PSDs 1 through 3 (unadjusted), the highest scores for worst pain (6–7 [out of 7] on Likert-type scale) were reported less frequently in each of the study groups than in subjects in the comparison group, although the numbers of subjects reporting the highest scores were few. The distribution of pain outcomes was significantly different among the 3 groups for worst pain and affective words on PSD 1 (P = .04 for both). However, the small number of subjects who reported the highest pain scores precluded adequate multivariate statistical analyses for all outcomes on PSD 1 to 3. Conclusions Data from this exploratory study suggest that adjunctive therapy to decrease postoperative pain

  8. Becaplermin Topical

    Science.gov (United States)

    ... a clean, non-absorbent surface such as wax paper. Do not touch the tip of the tube to the wax paper, the ulcer, or any other surface. Recap the ... to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in ...

  9. Fluorouracil Topical

    Science.gov (United States)

    ... are also used to treat a type of skin cancer called superficial basal cell carcinoma if usual types of treatment cannot be used. Fluorouracil is in a class of medications called antimetabolites. It ... such as the abnormal cells in actinic keratoses and basal cell carcinoma.

  10. ANNUAL INTERVIEWS (MAPS)

    CERN Multimedia

    Human Resources Division

    2002-01-01

    The calendar for the 2002/2003 annual interview programme is confirmed as normally from 15 November 2002 to 15 February 2002 as foreseen in Administrative Circular N° 26 (rev. 2). However, where it is preferred to be as close as possible to 12 months since the last interview, supervisors and staff concerned may agree to the interview taking place up to 15 March 2003. This may also be necessary due to the roles of different supervisors resulting from the particular situations of divisional re-restructurings and detachments this year. The report form template is as last year available on the HR Division Website. A banner on the internal homepage leads directly to the page with the form. In collaboration with AS Division, the MAPS form including the personal data for the first page can be generated via the Human Resources Toolkit (HRT) application. For this exercise each staff member can now generate his/her own MAPS form. Information about how to do this is available here. Human Resources Division Tel. ...

  11. The Effectiveness of Diagnostic Assessment on the Development of Turkish Language Learners’ Narrative Skills as an Oral Proficiency Interview (OPI Task

    Directory of Open Access Journals (Sweden)

    Anjel Tozcu

    2016-07-01

    Full Text Available This study investigated the effectiveness of diagnostic assessment on improving students’ proficiency in narrating past events, an Oral Proficiency Interview (OPI Level 2 task. It found that students who were given a personalized learning plan subsequent to the diagnostic assessment interview significantly improved their proficiency in basic sentence structures than those in a control group. They used a significantly larger number of cohesive devices as compared to the control group and exhibited significantly increased accuracy in using cohesive devices than a control group. The students in the treatment group worked on the recommended activities based on the data gathered during the diagnostic assessment interview and the pre-interview questionnaires, i.e., the E & L, MBTI, and Barsch. The students in the control group spent the same amount of time reading narrations, doing comprehension exercise,s and following standard teacher feedback for improvement. Although both groups showed increases in accurate use of cohesive devices and proficiency in basic sentence structures, the treatment students showed significantly greater gains than the control students.

  12. Land use and cover change as an overarching topic in the Dutch National Research Programme on Global Air Pollution and Climate Change : issues for implementation

    NARCIS (Netherlands)

    Fresco, L.O.; Berg, van den M.M.; Zeijl-Rozema, van A.E.

    1996-01-01

    The integration study 'Land Use and Cover Change as an overarching topic in the Dutch National Research Programme on Global Air Pollution and Climate Change (NRP)' aims at identifying research fields in which the NRP can contribute most effectively to the international scientific

  13. A prospective comparison of topical feracrylum citrate versus adrenaline as haemostatic agent in hypospadias surgery in children

    Directory of Open Access Journals (Sweden)

    Ashok Kumar Laddha

    2014-01-01

    Full Text Available Background: A comparative study of topical feracrylum citrate versus adrenaline to minimise haemorrhage-related complications in paediatric hypospadiac patients. Patients and Methods: A total of 108 consecutive paediatric hypospadiac patients (48 in the study group and 60 control - random allocation were studied. In the study group, 1% feracrylum citrate solution was used and adrenaline (1:100,000 in controls. Results: Among the study group, average number of blood-soaked gauge pieces were 2.95/patient, correlating with average intraoperative blood loss of 14.74 ml. In controls, average blood-soaked gauge pieces were 4.83/patient corresponding to an average blood loss of 24.13 ml. The average amount of blood loss during surgery in the <5 years was 13.70 ml/patient in the feracrylum group, while the same in the adrenaline group was 23.45 ml. Average duration of surgery was 79 min in the study group, while the same in controls was 94 min/patient. Average number of cauterisations was 0.255/patient in the study group and 0.583/patient among controls. Postoperative haematoma was seen in 8% study group compared with 18% controls. Wound oedema appeared in 4.17% study group and 11.67% controls. Postoperative complications were higher among controls. Conclusions: Feracrylum is more efficient and safer topical haemostatic agent than adrenaline. It reduced the frequency of cauterisation and tissue damage, intraoperative blood loss, and postoperative complications.

  14. A multicenter study of topical azelaic acid 15% gel in combination with oral doxycycline as initial therapy and azelaic acid 15% gel as maintenance monotherapy.

    Science.gov (United States)

    Thiboutot, Diane M; Fleischer, Alan B; Del Rosso, James Q; Rich, Phoebe

    2009-07-01

    This two-phase, multicenter study was undertaken to examine the safety and efficacy of combination therapy with oral doxycycline and topical azelaic acid (AzA) 15% gel in moderate-to-severe papulopustular rosacea and to determine the effect of subsequent maintenance monotherapy with AzA 15% gel alone. In the initial open-label, non-randomized phase of the study, subjects (n=172) received topical AzA 15% gel and oral doxycycline (100 mg), both twice daily, for or = 75% inflammatory lesion count reduction (n=136) were randomized to receive either AzA 15% gel or its vehicle twice daily for an additional 24 weeks. Assessments of efficacy were obtained at four-week intervals throughout both phases of the study and included change in inflammatory lesion count, investigator global assessment (IGA) of rosacea severity, and separate assessments of erythema and telangiectasia severity. At the last visit for each phase of the study, the investigator and participant each rated overall improvement, with the participant rating cosmetic acceptability and the investigator rating treatment as "success" or "failure" based on IGA score. During the second phase of the trial, the rate of relapse -- defined as either a 50% deterioration in the lesion count improvement from phase 1, an increase in erythema intolerable to the subject or maintenance therapy failure as judged by the investigator and/or the subject -- was obtained. Safety assessments were conducted for both phases of the study and included analysis of adverse events (AEs) and a rating of cutaneous tolerability by the subject. By week 12 of the open-label phase of the study, 81.4% of subjects had reached a 75% or greater reduction in inflammatory lesion count, and 64% of patients achieved treatment success. During the second study phase (maintenance phase), AzA 15% gel consistently provided a better maintenance response than vehicle, with maintenance of remission in 75% of patients over the six-month duration of the

  15. Topical immunomodulators in dermatology

    Directory of Open Access Journals (Sweden)

    Khandpur Sujay

    2004-04-01

    Full Text Available Topical immunomodulators are agents that regulate the local immune response of the skin. They are now emerging as the therapy of choice for several immune-mediated dermatoses such as atopic dermatitis, contact allergic dermatitis, alopecia areata, psoriasis, vitiligo, connective tissue disorders such as morphea and lupus erythematosus, disorders of keratinization and several benign and malignant skin tumours, because of their comparable efficacy, ease of application and greater safety than their systemic counterparts. They can be used on a domiciliary basis for longer periods without aggressive monitoring. In this article, we have discussed the mechanism of action, common indications and side-effects of the commonly used topical immunomodulators, excluding topical steroids. Moreover, newer agents, which are still in the experimental stages, have also been described. A MEDLINE search was undertaken using the key words "topical immunomodulators, dermatology" and related articles were also searched. In addition, a manual search for many Indian articles, which are not indexed, was also carried out. Wherever possible, the full article was reviewed. If the full article could not be traced, the abstract was used.

  16. On the assessment of children in suspected child sexual abuse in light of Daubert and Frye: limitations of profiles and interviews as scientifically grounded evidence.

    Science.gov (United States)

    Bigelow, B J

    2000-05-01

    Practice with children and families entails the higher probability of encountering forensic issues of child sexual abuse (CSA) assessments for which relatively few psychologists, allied mental health and legal practitioners are sufficiently well equipped. The current paper reviews some of the key psycholegal issues bearing on the assessment of suspected CSA in the contexts of: (a) recent psycholegal precedence and common law rules of reliability and admissibility of CSA profile evidence; (b) the empirical problems with CSA syndromes; and (c) the problems with children's interviews as evidence, and suggestions for valid interviewing guidelines supporting free recall. These psycholegal issues are presented in terms of the Frye standard for expert testimony and the Federal Rules of Evidence, with recent American and Canadian case illustrations, such as Daubert v. Merrell Dow Pharmaceuticals, Hadden v. State of Florida (1997), Bighead v. The United States of America (1997), Diocese of Winona v. Interstate Fire & Cas. Co. (1994), and R. v. Simpson (1996).

  17. Entrevista clínica com crianças e adolescentes vítimas de abuso sexual Clinic interview with children and adolescents sexually abused

    Directory of Open Access Journals (Sweden)

    Luísa Fernanda Habigzang

    2008-12-01

    Full Text Available O abuso sexual contra crianças e adolescentes é atualmente um problema de saúde pública. A complexidade do fenômeno requer a capacitação dos profissionais que atuam na avaliação e intervenção clínica das vítimas. O presente artigo tem como objetivo fornecer subsídios teóricos e práticos sobre a entrevista clínica com crianças e adolescentes vítimas de abuso sexual, visando à obtenção do relato sobre a experiência abusiva. Aspectos como as possíveis conseqüências do abuso sexual, o setting da entrevista, a postura dos entrevistadores e as características da revelação pela criança estão apresentadas, bem como um roteiro de entrevista.The sexual abuse against children and adolescents is an actual public health concern. The complexity of phenomenon requires special training of professionals who work in the clinic evaluation of victims and intervention. This study aims to provide theoretical and practical information about the clinic interview with victims of child sexual abuse, aiming at the attainment of the abusive experience report. An interview protocol is presented and the aspects discussed include: sexual abuse potential outcomes, the interview setting, the professional attitude, and children's disclosure.

  18. Approaches in topical ocular drug delivery and developments in the use of contact lenses as drug-delivery devices.

    Science.gov (United States)

    Mehta, Prina; Haj-Ahmad, Rita; Al-Kinani, Ali; Arshad, Muhammad Sohail; Chang, Ming-Wei; Alany, Raid G; Ahmad, Zeeshan

    2017-07-01

    Drug-delivery approaches have diversified over the last two decades with the emergence of nanotechnologies, smart polymeric systems and multimodal functionalities. The intended target for specific treatment of disease is the key defining developing parameter. One such area which has undergone significant advancements relates to ocular delivery. This has been expedited by the development of material advancement, mechanistic concepts and through the deployment of advanced process technologies. This review will focus on the developments within lens-based drug delivery while touching on conventional and current methods of topical ocular drug delivery. A summary table will provide quick reference to note the key findings in this area. In addition, the review also elucidates current theranostic and diagnostic approaches based on ocular lenses.

  19. Topical antibiotics as a major contextual hazard toward bacteremia within selective digestive decontamination studies: a meta-analysis.

    Science.gov (United States)

    Hurley, James C

    2014-12-31

    Among methods for preventing pneumonia and possibly also bacteremia in intensive care unit (ICU) patients, Selective Digestive Decontamination (SDD) appears most effective within randomized concurrent controlled trials (RCCT's) although more recent trials have been cluster randomized. However, of the SDD components, whether protocolized parenteral antibiotic prophylaxis (PPAP) is required, and whether the topical antibiotic actually presents a contextual hazard, remain unresolved. The objective here is to compare the bacteremia rates and patterns of isolates in SDD-RCCT's versus the broader evidence base. Bacteremia incidence proportion data were extracted from component (control and intervention) groups decanted from studies investigating antibiotic (SDD) or non-antibiotic methods of VAP prevention and summarized using random effects meta-analysis of study and group level data. A reference category of groups derived from purely observational studies without any prevention method under study provided a benchmark incidence. Within SDD RCCTs, the mean bacteremia incidence among concurrent component groups not exposed to PPAP (27 control; 17.1%; 13.1-22.1% and 12 intervention groups; 16.2%; 9.1-27.3%) is double that of the benchmark bacteremia incidence derived from 39 benchmark groups (8.3; 6.8-10.2%) and also 20 control groups from studies of non-antibiotic methods (7.1%; 4.8 - 10.5). There is a selective increase in coagulase negative staphylococci (CNS) but not in Pseudomonas aeruginosa among bacteremia isolates within control groups of SDD-RCCT's versus benchmark groups with data available. The topical antibiotic component of SDD presents a major contextual hazard toward bacteremia against which the PPAP component partially mitigates.

  20. Discovering health topics in social media using topic models.

    Directory of Open Access Journals (Sweden)

    Michael J Paul

    Full Text Available By aggregating self-reported health statuses across millions of users, we seek to characterize the variety of health information discussed in Twitter. We describe a topic modeling framework for discovering health topics in Twitter, a social media website. This is an exploratory approach with the goal of understanding what health topics are commonly discussed in social media. This paper describes in detail a statistical topic model created for this purpose, the Ailment Topic Aspect Model (ATAM, as well as our system for filtering general Twitter data based on health keywords and supervised classification. We show how ATAM and other topic models can automatically infer health topics in 144 million Twitter messages from 2011 to 2013. ATAM discovered 13 coherent clusters of Twitter messages, some of which correlate with seasonal influenza (r = 0.689 and allergies (r = 0.810 temporal surveillance data, as well as exercise (r =  .534 and obesity (r =  -.631 related geographic survey data in the United States. These results demonstrate that it is possible to automatically discover topics that attain statistically significant correlations with ground truth data, despite using minimal human supervision and no historical data to train the model, in contrast to prior work. Additionally, these results demonstrate that a single general-purpose model can identify many different health topics in social media.

  1. Interview als Text vs. Interview als Interaktion

    Directory of Open Access Journals (Sweden)

    Arnulf Deppermann

    2013-09-01

    Full Text Available Das Interview ist nach wie vor das beliebteste sozialwissenschaftliche Verfahren des Datengewinns. Ökonomie der Erhebung, Vergleichbarkeit und die Möglichkeit, Einsicht in Praxisbereiche und historisch-biografische Dimensionen zu erhalten, die der direkten Beobachtung kaum zugänglich sind, machen seine Attraktivität aus. Zugleich mehren sich Kritiken, die seine Leistungsfähigkeit problematisieren, indem sie auf die begrenzte Reichweite der Explikationsfähigkeiten der Befragten, die Reaktivität der Erhebung oder die Differenz zwischen Handeln und dem Bericht über Handeln verweisen. Im Beitrag wird zwischen Ansätzen, die das Interview als Text, und solchen, die es als Interaktion verstehen, unterschieden. Nach dem Text-Verständnis werden Interviews unter inhaltlichen Gesichtspunkten analysiert und als Zugang zu einer vorgängigen sozialen oder psychischen Wirklichkeit angesehen. Das Interaktions-Verständnis versteht Interviews dagegen als situierte Praxis, in welcher im Hier und Jetzt von InterviewerInnen und Befragten gemeinsam soziale Sinnstrukturen hergestellt werden. Anhand ubiquitärer Phänomene der Interviewinteraktion – Fragen, Antworten und die Selbstpositionierung von InterviewerInnen und Befragten – werden Praktiken des interaktiv-performativen Handelns im Interview dargestellt. Ihre Relevanz für die Interviewkonstitution und ihre Erkenntnispotenziale für die Interviewauswertung werden aufgezeigt. Es wird dafür plädiert, die interaktive Konstitutionsweise von Interviews empirisch zu erforschen und methodisch konsequent zu berücksichtigen. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1303131

  2. Close up on remote interviews.

    Science.gov (United States)

    Higgins, Mike

    2014-10-21

    Embrace it or shy away from it, the march of technology moves onwards relentlessly. Job interviews, often seen as the most human part of the recruitment process, are increasingly moving to video conference or services such as Skype or FaceTime, especially for a first interview.

  3. The `What is a system' reflection interview as a knowledge integration activity for high school students' understanding of complex systems in human biology

    Science.gov (United States)

    Tripto, Jaklin; Ben-Zvi Assaraf, Orit; Snapir, Zohar; Amit, Miriam

    2016-03-01

    This study examined the reflection interview as a tool for assessing and facilitating the use of 'systems language' amongst 11th grade students who have recently completed their first year of high school biology. Eighty-three students composed two concept maps in the 10th grade-one at the beginning of the school year and one at its end. The first part of the interview is dedicated to guiding the students through comparing their two concept maps and by means of both explicit and non-explicit teaching. Our study showed that the explicit guidance in comparing the two concept maps was more effective than the non-explicit, eliciting a variety of different, more specific, types of interactions and patterns (e.g. 'hierarchy', 'dynamism', 'homeostasis') in the students' descriptions of the human body system. The reflection interview as a knowledge integration activity was found to be an effective tool for assessing the subjects' conceptual models of 'system complexity', and for identifying those aspects of a system that are most commonly misunderstood.

  4. A Study With Special Emphasis On Applying Motivational Interviewing As a Clinical Approach to Change Addictive Behavior of Drug Abusers in Iran

    Directory of Open Access Journals (Sweden)

    Majid Ghorbani

    2002-10-01

    The goals of present article are three – fold: In the first step, it introduces a brief form of motivational Interviewing for addictive behaviors. Its primary basis is the idea that most substance abusers seek medical treatment without being ready to change addictive behaviors. As a result, attempts the addicts to change often lead to their resistance. Therefore, the use of motivational interviewing (MI in which clients are directed towards realizing their own reasons and arguments for changing their behavior, seems to be most oppropriate to motivate and prepare them for change. In the second step, the article tries to discuss advantages of motivational interviewing approach to often opproaches (e.g, skills training approach, Indirect approach and confrontational – denial approach and suggests that (MI is the most appropriate strategy for the substance abusers, according to their degree of readiness for change. Finally in the third step, the article attempts to indicate the current dominant strategies of addiction treatment in Iran and concludes that due to dominance and commonality of medicine – based treatment strategies of addictive behaviors, (MI could be introduced as an alternative and appropriate treatment strategy for drug addicts in Iran.

  5. Interview with Dr Anna Matamala

    Directory of Open Access Journals (Sweden)

    Lucinea Marcelino Villela

    2016-12-01

    Full Text Available In this interview, which took place in June 2016, Dr Anna Matamala described some details about her long professional experience in Audiovisual Translation, especially in dubbing from English into Catalan, and we talked about many other things like her interest in lexicography, her point of view on some contemporary topics in Audiovisual Translation Studies: the use of technology, the relation between AVT and Accessibility Studies, AVT and Filmmaking fields, the importance of keeping in touch with other countries and even continents outside Europe, and she also gave some advice to the new generation of Translation students.

  6. Interview with Dr Anna Matamala

    Directory of Open Access Journals (Sweden)

    Lucinea Marcelino Villela

    2016-09-01

    In this interview, which took place in June 2016, Dr Anna Matamala described some details about her long professional experience in Audiovisual Translation, especially in dubbing from English into Catalan, and we talked about many other things like her interest in lexicography, her point of view on some contemporary topics in Audiovisual Translation Studies: the use of technology, the relation between AVT and Accessibility Studies, AVT and Filmmaking fields, the importance of keeping in touch with other countries and even continents outside Europe, and she also gave some advice to the new generation of Translation students.

  7. Interviewing children as a tool for teachers’ professional development - A reaction to Doug Clarke’s plenary lecture

    NARCIS (Netherlands)

    Heuvel-Panhuizen, M.H.A.M van den

    2013-01-01

    First I like to thank the organizers of the PME 37 conference for inviting me to act as a reactor to this plenary talk of Doug Clarke. I hope that my somewhat provocative thoughts are stuff for further thinking about the valuable work of Doug Clarke and his colleagues. To put my critical remarks

  8. DETOUR - Towards Pre-trial Detention as Ultima Ratio : 2nd Dutch National Report on Expert Interviews

    NARCIS (Netherlands)

    Boone, M.M.; Lindeman, J.M.W.; Jacobs, P.

    This national report is created within a European research project, commissioned by the Europe-an Commission, with the title ‘DETOUR – Towards Pre-trial Detention as Ultima Ratio’ that was conducted in 2016-2017. The research project aimed at exploring and analysing pre-trial detention practice,

  9. Contact dermatitis as an adverse reaction to some topically used European herbal medicinal products - part 1: Achillea millefolium-Curcuma longa.

    Science.gov (United States)

    Calapai, Gioacchino; Miroddi, Marco; Minciullo, Paola L; Caputi, Achille P; Gangemi, Sebastiano; Schmidt, Richard J

    2014-07-01

    This review focuses on contact dermatitis as an adverse effect of a selection of topically used herbal medicinal products for which the European Medicines Agency has completed an evaluation up to the end of November 2013 and for which a Community herbal monograph has been produced. Part 1: Achillea millefolium L.-Curcuma longa L. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  10. Attendance at cultural events, reading books or periodicals, and making music or singing in a choir as determinants for survival: Swedish interview survey of living conditions.

    Science.gov (United States)

    Bygren, L O; Konlaan, B B; Johansson, S E

    To investigate the possible influence of attendance at cultural events, reading books or periodicals, making music or singing in a choir as determinants for survival. A simple random sample was drawn of 15,198 individuals aged 16-74 years. Of these, 85% (12,982) were interviewed by trained non-medical interviewers between 1982 and 1983 about cultural activities. They were followed up with respect to survival until 31 December 1991. Swedish interview survey of living conditions comprising a random sample of the adult Swedish population. 12,675 people interviewed between 1982 and 1983. Survival of subjects after controlling for eight confounding variables: age, sex, education level, income, long term disease, social network, smoking, and physical exercise. 6,301 men and 6,374 women were followed up; 533 men and 314 women died during this period. The control variables influenced survival in the expected directions except for social network for men; a significant negative effective was found when the analysis was made separately for men and women. We found an influence on mortality when the eight control variables were controlled for in people who rarely attended events compared with those attending most often, the relative risk being 1.57 (95% confidence interval 1.18 to 2.09). Attendance at cultural events may have a positive influence on survival. Long term follow up of large samples with confounders that are well controlled for and with the cultural stimulation more highly specified should be used to try to falsify the hypothesis before experiments start.

  11. Attendance at cultural events, reading books or periodicals, and making music or singing in a choir as determinants for survival: Swedish interview survey of living conditions.

    Science.gov (United States)

    Bygren, L. O.; Konlaan, B. B.; Johansson, S. E.

    1996-01-01

    OBJECTIVES: To investigate the possible influence of attendance at cultural events, reading books or periodicals, making music or singing in a choir as determinants for survival. DESIGN: A simple random sample was drawn of 15,198 individuals aged 16-74 years. Of these, 85% (12,982) were interviewed by trained non-medical interviewers between 1982 and 1983 about cultural activities. They were followed up with respect to survival until 31 December 1991. SETTING: Swedish interview survey of living conditions comprising a random sample of the adult Swedish population. SUBJECTS: 12,675 people interviewed between 1982 and 1983. MAIN OUTCOME MEASURES: Survival of subjects after controlling for eight confounding variables: age, sex, education level, income, long term disease, social network, smoking, and physical exercise. RESULTS: 6,301 men and 6,374 women were followed up; 533 men and 314 women died during this period. The control variables influenced survival in the expected directions except for social network for men; a significant negative effective was found when the analysis was made separately for men and women. We found an influence on mortality when the eight control variables were controlled for in people who rarely attended events compared with those attending most often, the relative risk being 1.57 (95% confidence interval 1.18 to 2.09). CONCLUSION: Attendance at cultural events may have a positive influence on survival. Long term follow up of large samples with confounders that are well controlled for and with the cultural stimulation more highly specified should be used to try to falsify the hypothesis before experiments start. PMID:8990990

  12. Interview: Joseph Agassi

    Directory of Open Access Journals (Sweden)

    Joseph Agassi

    2016-12-01

    Full Text Available Joseph Agassi is an Israeli scholar born in Jerusalem on May 7, 1927. He has many books and articles published contributing to the fields of logic, scientific method, foundations of sciences, epistemology and, most importantly for this Journal, in the historiography of science. He studied with Karl Popper, who was definitely his biggest influence. He taught around the world in different universities. He currently lives in Herzliya, Israel. For his important contribution to the historiography of science, we chose to open the first issue of this journal with this interview recognizing his importance for the field, as well as paying our homage to him.

  13. Communicating about obesity and weight-related topics with children with a physical disability and their families: spina bifida as an example.

    Science.gov (United States)

    McPherson, Amy C; Swift, Judy A; Peters, Michelle; Lyons, Julia; Joy Knibbe, Tara; Church, Paige; Chen, Lorry; Farrell, Renée M; Willem Gorter, Jan

    2017-04-01

    The purpose of this study was to explore the experiences of children with spina bifida (SB), their families and healthcare professionals (HCPs) when discussing weight-related topics. In-depth qualitative interviews were conducted with HCPs from Canadian outpatient SB clinics (n = 13), children aged 6-18 years with SB (n = 17) and their parents (n = 20). Data were analyzed using a phenomenological approach within an interpretative paradigm. Many HCPs were not confident talking about weight, concerned that they would damage relationships with children and families. Parents wanted routine weight surveillance, but were worried about their children's self-esteem if their weight was discussed. They wanted HCPs to acknowledge the challenges of weight management in children with a physical disability and provide specialized solutions. Children wanted a positively framed and tailored approach to weight discussions, although this had generally not been their experience. Stakeholders describe therapeutic relationships that are currently disconnected around the issue of weight and obesity. However, children, parents and HCPs all believed that discussing this topic was critical. Positively framed, strengths-based and tailored approaches to weight-related discussions are warranted. Implications for Rehabilitation Rates of overweight and obesity in children and youth with physical disabilities are substantially higher than their typically developing peers. Healthcare professionals, children with physical disabilities and families often find weight-related discussions challenging and disconnected. Weight-related discussions should be tailored to the child and family's circumstances and priorities. Positively framed and strengths-based approaches to weight-related discussions are warranted.

  14. Introducing Scientific Writing as Mandatory Topic in Bachelor Nursing Program - Experience of the University of Dubrovnik, Croatia.

    Science.gov (United States)

    Zidarić, Mihaela; Vičić-Hudorović, Višnja; Hudorović, Narcis

    2016-06-01

    One of the methods that have been used to encourage student reflection skills is scientific writing. The purpose of this article is to discuss implementation of obligatory study topic with the main objective to increase the skills of scientific writing among students of Bachelor Nursing Curriculum and its relation to scientific publishing volume of Bachelor degree students from the University of Dubrovnik. By searching the local rank database called HRČAK, data were collected on publication volume of the Bachelor course students at the University of Dubrovnik from 2010 to 2014. Articles published in the Croatian medical journals in Croatian language were identified. Sixty-six students published 35 articles, alone or with co-authors. Two (6%) articles were written by a single author. Among co-authors from the nursing profession, those with associate degree in nursing (20%) predominated, followed by medical doctors and anthropologists (25%). The total number of authors was 95, and the share of papers published in Croatian language was 100%. The body of published articles increased from 2012 to 2013 by 14%, and then from 2013 to 2014 by 113%. For future investigations, closer insight into novel approaches is needed to encourage nursing students to increase their scientific productivity, especially in English language. In order to enhance international visibility of Croatian nursing authors, academic members of the Croatian scientific nursing community should find additional tools to upgrade scientific productivity of the Croatian nursing authors.

  15. Interview without a subject

    DEFF Research Database (Denmark)

    Rittenhofer, Iris

    2010-01-01

    This article contributes to the rethinking of qualitative interview research into intercultural issues. It suggests that the application of poststructuralist thought should not be limited to the analysis of the interview material itself, but incorporate the choice of interviewees and the modalities...... for the accomplishment of interviews. The paper focuses on a discussion of theoretical and methodological considerations of design, approach and research strategy. These discussions are specified in relation to a project on gender and ethnicity in cultural encounters at Universities. In the paper, I introduce a research...... design named Cultural interviewing, present an approach to the design of interviews named Interview without a subject, and offer an analytic strategy directed towards the analysis of interview transcripts named Interview on the level of the signifier. The paper concludes that even though it is relevant...

  16. Paediatric Virology as a new educational initiative: An interview with Nobelist Professor of Virology Harald zur Hausen.

    Science.gov (United States)

    Mammas, Ioannis N; Spandidos, Demetrios A

    2017-10-01

    Born in Gelsenkirchen-Buer in Germany on March 11th, 1936, Professor Harald zur Hausen, Emeritus Professor of Virology at the University of Freiburg and 2008 Nobel Prize Laureate in Physiology or Medicine for his discovery of human papillomavirus (HPV), which causes cervical cancer, believes that good knowledge of virological methods and diagnostic possibilities are an asset for all young paediatricians. Professor zur Hausen considers that the creation of an educational platform on Paediatric Virology is definitely very beneficial for young paediatricians, as this will greatly enhance their knowledge in the field of Virology. He very actively advocates the vaccination of boys for the eradication of HPV infection and emphasises that male HPV vaccination should be included into the current vaccination programmes. He would have certainly considered Dr George N. Papanicolaou (Kyme, Island of Euboea, Greece, 1883 - Miami, Florida, USA, 1962) as an excellent candidate for the Nobel Prize, stating that the contribution of Dr Papanicolaou did not find sufficient recognition in the past. In the context of the 3rd Workshop on Paediatric Virology, which will be held in Athens, Greece, on October 7th, 2017, Professor zur Hausen will give his plenary lecture on 'Paediatric Virology and Oncology: Virus persistence and the important first years of life'.

  17. Alkyl polyglucoside-stabilized emulsion as a prospective vehicle for Usnea barbata CO2-supercritical extract: Assessing stability, safety and efficiency of a topical formulation

    Directory of Open Access Journals (Sweden)

    Žugić Ana R.

    2015-01-01

    Full Text Available Antimicrobial activity of Usnea barbata especially against bacteria involved in pathogenesis of various skin conditions has been well documented in literature. Nevertheless, there are no papers dealing with formulation of its isolates into topical preparations for treatment of skin infections. In present study, alkyl polyglucoside (APG - based vehicle was developed as carrier of U. barbata CO2-supercritical extract (U-SE that demonstrated the best antimicrobial potential in preliminary screening. For comparison, chosen extract in the same concentration and using the same procedure was incorporated into a pharmacopoeial vehicle. Comparative evaluation of physicochemical stability, efficiency and safety proved APG-based vehicle to possess certain preferential features as carrier of U-SE compared to the reference one, composing a topical formulation with potential clinical relevance in treatment of skin infections. [Projekat Ministarstva nauke Republike Srbije, br. III45017 i br. TR34031

  18. Topical rapamycin as a treatment for fibrofolliculomas in Birt-Hogg-Dubé syndrome: a double-blind placebo-controlled randomized split-face trial.

    Directory of Open Access Journals (Sweden)

    Lieke M C Gijezen

    Full Text Available Birt-Hogg-Dubé syndrome (BHD is a rare autosomal dominant disorder characterised by the occurrence of benign, mostly facial, skin tumours called fibrofolliculomas, multiple lung cysts, spontaneous pneumothorax and an increased renal cancer risk. Current treatments for fibrofolliculomas have high rates of recurrence and carry a risk of complications. It would be desirable to have a treatment that could prevent fibrofolliculomas from growing. Animal models of BHD have previously shown deregulation of mammalian target of rapamycin (mTOR. Topical use of the mTOR inhibitor rapamycin is an effective treatment for the skin tumours (angiofibromas in tuberous sclerosis complex, which is also characterised by mTOR deregulation. In this study we aimed to determine if topical rapamycin is also an effective treatment for fibrofolliculomas in BHD.We performed a double blinded, randomised, facial left-right controlled trial of topical rapamycin 0.1% versus placebo in 19 BHD patients. Trial duration was 6 months. The primary outcome was cosmetic improvement as measured by doctors and patients. Changes in fibrofolliculoma number and size were also measured, as was occurrence of side effects.No change in cosmetic status of fibrofolliculomas was reported in the majority of cases for the rapamycin treated (79% by doctors, 53% by patients as well as the placebo treated facial sides (both 74%. No significant differences between rapamycin and placebo treated facial halves were observed (p = 1.000 for doctors opinion, p = 0.344 for patients opinion. No significant difference in fibrofolliculoma number or change in size of the fibrofolliculomas was seen after 6 months. Side effects occurred more often after rapamycin treatment (68% of patients than after placebo (58% of patients; p = 0.625. A burning sensation, erythema, itching and dryness were most frequently reported.This study provides no evidence that treatment of fibrofolliculomas with topical

  19. Evaluation of Carbohydrate-Derived Fulvic Acid (CHD-FA) as a Topical Broad-Spectrum Antimicrobial for Drug-Resistant Wound Infections

    Science.gov (United States)

    2016-10-01

    of Carbohydrate-Derived Fulvic Acid (CHD-FA) as a Topical Broad- Spectrum Antimicrobial for Drug- Resistant Wound Infections 5b. GRANT NUMBER 5c...demonstrated the antimicrobial properties of Carbohydrate-Derived Fulvic Acid (CHD-FA) against a broad collection of multi-drug resistant bacterial and...spectrum antimicrobial for drug- resistant wound infections) at the 54th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2014

  20. Use of interviews in nursing research.

    Science.gov (United States)

    Mitchell, Gary

    2015-06-24

    Conducting interviews is one of the most common ways of collecting data in healthcare research. In particular, interviews are associated with qualitative research, where researchers seek to understand participants' experiences through their own words and perspectives. This article will help healthcare researchers prepare to carry out interviews as part of their research. It will also emphasise important skills to consider during the interview process. Consideration will also be given to remedying interviews that do not go according to plan, as well as identifying appropriate debriefing processes post-interview. With this knowledge, healthcare researchers are more likely to conduct effective interviews that will yield better quality data and protect the participant.

  1. Use of abnormal and health psychology as topics in a classroom format to reduce alcohol and other drug abuse among college students at risk.

    Science.gov (United States)

    Miley, W M

    2001-12-01

    This study was done to assess whether classes containing topics derived from two college courses, Abnormal Psychology and Health Psychology, could be used in a class room format to reduce alcohol and other drug abuse among at-risk college students. Topics covered included stress and stress management, alcohol and other drug use and abuse, chronic illnesses and psychological disorders that develop from an unhealthy lifestyle, and factors that play a role in good health and well-being. Students were enrolled in a semester-long course for college credit as an alternative to punitive sanctions for on-campus alcohol violations and other drug violations. The Midwest Institute on Drug Use Survey and the CORE Alcohol and Drug Survey were administered on the first and last days of class. Analysis indicated a significant self-reported reduction in drug use and associated negative symptoms and behavioral effects. Women were more likely to report reductions in drug use than men.

  2. Coding interview questions concepts, problems, interview questions

    CERN Document Server

    Karumanchi, Narasimha

    2016-01-01

    Peeling Data Structures and Algorithms: * Programming puzzles for interviews * Campus Preparation * Degree/Masters Course Preparation * Instructor’s * GATE Preparation * Big job hunters: Microsoft, Google, Amazon, Yahoo, Flip Kart, Adobe, IBM Labs, Citrix, Mentor Graphics, NetApp, Oracle, Webaroo, De-Shaw, Success Factors, Face book, McAfee and many more * Reference Manual for working people

  3. ANNUAL INTERVIEWS (MAPS)

    CERN Multimedia

    2003-01-01

    For the performance appraisal of reference year 2003, the interview calendar has been fixed between 1 January and 31 March 2004. This new calendar gives a better time schedule to the supervisors to conduct the interviews. This may also be necessary due to the roles of different supervisors resulting from the particular situations of the new CERN structure as from 2004. With this later time limit, the new departments are invited to strictly respect the target date of 31 March. The report form template is as last year available on the HR Division Website. A banner on the internal homepage: http://cern.ch/hr-div will lead directly to the page with the form. The personal data for the first page of the form can be generated by each divisional hierarchy, by the Divisional Administrative Officer (DAO) or by the staff member himself via HRT. Following discussions about the first two years of MAPS, and in order to improve the performance appraisal process, some modifications have been brought to section 2 (Assessme...

  4. The addition of a goal-based motivational interview to standardised treatment as usual to reduce dropouts in a service for patients with personality disorder: a feasibility study.

    Science.gov (United States)

    McMurran, Mary; Cox, W Miles; Coupe, Stephen; Whitham, Diane; Hedges, Lucy

    2010-10-14

    Rates of non-completion of treatments for personality disorder are high and there are indications that those who do not complete treatment have worse outcomes than those who do. Improving both cost-efficiency and client welfare require attention to engaging people with personality disorder in treatment. A motivational interview, based on the Personal Concerns Inventory, may have the ability to enhance engagement and retention in therapy. Here, we report the protocol for a feasibility study for a randomised controlled trial (RCT). All referrals accepted to the psychological service of Nottinghamshire Healthcare NHS Trust's outpatient service for people with personality disorder are eligible for inclusion. Consenting participants are randomised to receive the Personal Concerns Inventory interview plus treatment as usual or treatment as usual only. We aim to recruit 100 participants over 11/2 years. A randomised controlled trial will be considered feasible if 1 the recruitment rate to the project is 54% of all referrals (95% CI 54-64), 2 80% of clients find the intervention acceptable in terms of its practicability and usefulness (95% CI 80-91), and 3 80% of therapists report finding the intervention helpful (95% CI 80-100). In a full-scale randomised controlled trial, the primary outcome measure will be completion of treatment i.e., entry into and completion of ≥ 75% of sessions offered. Therefore, information will be collected on recruitment rates, attendance at therapy sessions, and completion of treatment. The feasibility of examining the processes of engagement will be tested by assessing the value, coherence, and attainability of goals pre-treatment, and engagement in treatment. The costs associated with the intervention will be calculated, and the feasibility of calculating the cost-benefits of the intervention will be tested. The views of clients and therapists on the intervention, collected using semi-structured interviews, will be analysed using thematic

  5. The addition of a goal-based motivational interview to standardised treatment as usual to reduce dropouts in a service for patients with personality disorder: a feasibility study

    Directory of Open Access Journals (Sweden)

    Whitham Diane

    2010-10-01

    Full Text Available Abstract Background Rates of non-completion of treatments for personality disorder are high and there are indications that those who do not complete treatment have worse outcomes than those who do. Improving both cost-efficiency and client welfare require attention to engaging people with personality disorder in treatment. A motivational interview, based on the Personal Concerns Inventory, may have the ability to enhance engagement and retention in therapy. Here, we report the protocol for a feasibility study for a randomised controlled trial (RCT. Methods All referrals accepted to the psychological service of Nottinghamshire Healthcare NHS Trust's outpatient service for people with personality disorder are eligible for inclusion. Consenting participants are randomised to receive the Personal Concerns Inventory interview plus treatment as usual or treatment as usual only. We aim to recruit 100 participants over 11/2 years. A randomised controlled trial will be considered feasible if 1 the recruitment rate to the project is 54% of all referrals (95% CI 54-64, 2 80% of clients find the intervention acceptable in terms of its practicability and usefulness (95% CI 80-91, and 3 80% of therapists report finding the intervention helpful (95% CI 80-100. In a full-scale randomised controlled trial, the primary outcome measure will be completion of treatment i.e., entry into and completion of ≥ 75% of sessions offered. Therefore, information will be collected on recruitment rates, attendance at therapy sessions, and completion of treatment. The feasibility of examining the processes of engagement will be tested by assessing the value, coherence, and attainability of goals pre-treatment, and engagement in treatment. The costs associated with the intervention will be calculated, and the feasibility of calculating the cost-benefits of the intervention will be tested. The views of clients and therapists on the intervention, collected using semi

  6. What do speech-language pathologists describe as most important when trying to achieve client participation during aphasia rehabilitation? A qualitative focus group interview study.

    Science.gov (United States)

    Berg, Karianne; Askim, Torunn; Rise, Marit By

    2017-12-18

    The aim of this study was to investigate what speech-language pathologists describe as most important when trying to achieve client-oriented participation during aphasia rehabilitation. A qualitative study including semi-structured focus group interviews with 11 speech-language pathologists. Interviews were analysed with the use of systematic text condensation. Four main themes emerged from the analysis. (1) It is important to take the vulnerability of the client group into account. (2) It is important to address the client's process of realisation by navigating around unrealistic wishes and goals. (3) It is challenging to involve clients when the evidence-base for clinical practice is limited. (4) It is crucial to make therapy meaningful to the client. This study showed that speech-language pathologists perceived prediction of a clinical course in aphasia rehabilitation as challenging due to the vulnerable client group and the perceived need to guide the clients through the rehabilitation process. They talked about how unrealistic client goals, and the lack of a solid evidence-base to guide their clinical practice, made collaborative goal setting and treatment planning challenging. Due to these barriers, the speech-language pathologists struggled to achieve client participation, and thereby aphasia rehabilitation could not be described as fully client-oriented.

  7. Computer-Administered Interviews and Rating Scales

    Science.gov (United States)

    Garb, Howard N.

    2007-01-01

    To evaluate the value of computer-administered interviews and rating scales, the following topics are reviewed in the present article: (a) strengths and weaknesses of structured and unstructured assessment instruments, (b) advantages and disadvantages of computer administration, and (c) the validity and utility of computer-administered interviews…

  8. Understanding Infidelity: An Interview with Gerald Weeks

    Science.gov (United States)

    Smith, Travis

    2011-01-01

    In this interview, Gerald Weeks shares his expertise on the topic of infidelity and couples counseling. Dr. Weeks defines infidelity, presents assessment strategies for treating the issue of infidelity, and discusses an intersystemic model for infidelity treatment when counseling couples. Dr. Weeks also provides insight into common mistakes made…

  9. Interview with Karol Modzelewski

    Directory of Open Access Journals (Sweden)

    Paola Guglielmotti

    2010-06-01

    Full Text Available The first section of this interview addresses the political and cultural milieu that shaped Karol Modzelewski’s education (in Poland and Italy, too, the relations with both his mentor Aleksander Gieysztor and the historians of the previous generation, the condition of education in Poland especially in the ’60s, his political involvement, the selection of his research interests and the development the latter underwent. Then the interview examines Modzelewski’s relations with scholars belonging to other historiographical schools, with particular attention to the issue of ethnogenesis, the methodology concerning the structure of sources to reconstruct the history of the Barbarian world in the first millennium, the matter of the “Barbaric collectivism”, the reception of his study L’Europa dei barbari (‘The Europe of the Barbarians’, 2004, and finally how research is organized and evaluated in Poland. Quotable as Intervista a Karol Modzelewski, a cura di Paola Guglielmotti e Gian Maria Varanini, "Reti Medievali - Rivista", 11, 1 (2010, p. 509-579, url: .

  10. Interviews within experimental frameworks

    DEFF Research Database (Denmark)

    Reinhard, CarrieLynn D.

    2010-01-01

    -making processes in relatively inexperienced people as they engage with virtual worlds.  In order to understand the sense-making of virtual worlds, a method to record the interpretive process, as well as physical actions, was required.  In order to understand the sense-making processes involved in new experiences......, an amount of control was required over the nature of those experiences.  With these requirements, a hybrid study was designed by deconstructing the conceptualization of "the experiment" and utilizing both quantitative and qualitative methods.  The resulting study involved the following: a within-subjects......, and afterwards when they were asked to recall and compare these situations in open-ended questionnaires and interviews structured using Dervin's Sense-Making Methodology.  Having completed the study using this mixed method(ology) approach, I discuss the effectiveness of this approach, and where the approach...

  11. Emotions related to participation restrictions as experienced by patients with early rheumatoid arthritis: a qualitative interview study (the Swedish TIRA project).

    Science.gov (United States)

    Östlund, Gunnel; Björk, Mathilda; Thyberg, Ingrid; Thyberg, Mikael; Valtersson, Eva; Stenström, Birgitta; Sverker, Annette

    2014-01-01

    Psychological distress is a well-known complication in rheumatoid arthritis (RA), but knowledge regarding emotions and their relationship to participation restrictions is scarce. The objective of the study was to explore emotions related to participation restrictions by patients with early RA. In this study, 48 patients with early RA, aged 20-63 years, were interviewed about participation restrictions using the critical incident technique. Information from transcribed interviews was converted into dilemmas and linked to International Classification of Functioning, Disability, and Health (ICF) participation codes. The emotions described were condensed and categorized. Hopelessness and sadness were described when trying to perform daily activities such as getting up in the mornings and getting dressed, or not being able to perform duties at work. Sadness was experienced in relation to not being able to continue leisure activities or care for children. Examples of fear descriptions were found in relation to deteriorating health and fumble fear, which made the individual withdraw from activities as a result of mistrusting the body. Anger and irritation were described in relation to domestic and employed work but also in social relations where the individual felt unable to continue valued activities. Shame or embarrassment was described when participation restrictions became visible in public. Feelings of grief, aggressiveness, fear, and shame are emotions closely related to participation restrictions in everyday life in early RA. Emotions related to disability need to be addressed both in clinical settings in order to optimize rehabilitative multi-professional interventions and in research to achieve further knowledge.

  12. [Motivational interview: supporting change].

    Science.gov (United States)

    Fond, Guillaume; Ducasse, Déborah

    2015-01-01

    The motivational interview aims to help patients to resolve their ambivalence regarding problematic behaviors and to guide them into change. It differs from other therapeutic approaches mainly through the attitude of the therapist. In motivational interviewing, the therapist defends the statu quo. By reactance, the patient defends the change and enhance her/his motivation. This article provides a summary of the other concepts of motivational interviewing and its applications in the psychiatric daily practice. Copyright © 2015. Published by Elsevier Masson SAS.

  13. Comparing appropriateness and equivalence of email interviews to phone interviews in qualitative research on reproductive decisions.

    Science.gov (United States)

    Hershberger, Patricia E; Kavanaugh, Karen

    2017-10-01

    Despite an increasing use of qualitative email interviews by nurse researchers, there is little understanding about the appropriateness and equivalence of email interviews to other qualitative data collection methods, especially on sensitive topics research. The purpose is to describe our procedures for completing asynchronous, email interviews and to evaluate the appropriateness and equivalency of email interviews to phone interviews in two qualitative research studies that examined reproductive decisions. Content analysis guided the methodological appraisal of appropriateness and equivalency of in-depth, asynchronous email interviews to single phone interviews. Appropriateness was determined by: (a) participants' willingness to engage in email or phone interviews, (b) completing data collection in a timely period, and (c) participants' satisfaction with the interview. Equivalency was evaluated by: (a) completeness of the interview data, and (b) insight obtained from the data. Of the combined sample in the two studies (N=71), 31% of participants chose to participate via an email interview over a phone interview. The time needed to complete the email interviews averaged 27 to 28days and the number of investigator probe-participant response interchanges was 4 to 5cycles on average. In contrast, the phone interviews averaged 59 to 61min in duration. Most participants in both the email and phone interviews reported they were satisfied or very satisfied with their ability to express their true feelings throughout the interview. Regarding equivalence, 100% of the email and phone interviews provided insight into decision processes. Although insightful, two of the email and one phone interview had short answers or, at times, underdeveloped responses. Participants' quotes and behaviors cited within four published articles, a novel evaluation of equivalency, revealed that 20% to 37.5% of the citations about decision processes were from email participants, which is

  14. Doing Dirty Interviewing

    DEFF Research Database (Denmark)

    Lippke, Lena; Tanggaard, Lene

    in the position of a psychologist with past experiences within supervision and consultation/coaching. The framing of the interview was build around the theme “My role in keeping students out from dropping out of the Vocational Educational Training College.” We will discuss how both the interviewer...... and the interviewee might seduce each other to develop a conversation in which intersections between supervision/coaching and interviewing merge. The example clearly demonstrates how subjectivity influences the knowledge that is being produced in an interview situation, which should be recognized and reflected upon...

  15. Det kvalitative interview

    DEFF Research Database (Denmark)

    Brinkmann, Svend

    Bogen begynder med en teoretisk funderet introduktion til det kvalitative interview gennem en skildring af de mange forskellige måder, hvorpå samtaler er blevet brugt til produktion af viden. Opmærksomheden henledes specielt på de komplementære positioner, der kendetegner det oplevelsesfokuserede...... interview (fænomenologiske positioner) og det sprogfokuserede interview (diskursorienterede positioner), som henholdsvis fokuserer på interviewsamtalen som rapporter (om interviewpersonens oplevelser) og redegørelser (foranlediget af interviewsituationen). De følgende kapitler omhandler forskellige måder...... forskningsresultater baseret på kvalitative interview....

  16. Interview: Drew Feustel

    Directory of Open Access Journals (Sweden)

    Paul J. Sliker

    2011-01-01

    Full Text Available An interview with Andrew J. (Drew Feustel, Purdue alum, geophysicist and NASA astronaut. Dr. Feustel's first spaceflight in May 2009 (STS-125 repaired the Hubble Space Telescope. His second spaceflight in May 2011 (STS-134 was the penultimate journey of the Space Shuttle program. At Purdue University, Feustel served as a Residence Hall Counselor for two years at Cary Quadrangle and he was a Research Assistant and Teaching Assistant in the Department of Earth and Atmospheric Sciences. His MS thesis investigated physical property measurements of rock specimens under elevated hydrostatic pressures simulating Earth’s deep crustal environments. While at Purdue, Feustel served for three years as Grand Prix Chairman and team Kart driver for Sigma Phi Epsilon Fraternity.

  17. Disrupting the habit of interviewing

    Directory of Open Access Journals (Sweden)

    Eileen Honan

    2014-06-01

    Full Text Available This paper contributes to the growing domain of ‘post-qualitative’ research and experiments with a new (representational form to move away from traditional and clichéd descriptions of research methods. In this paper, I want to interrogate the category of interview, and the habit of interviewing, to disrupt the clichés, so as to allow thinking of different ways of writing/speaking/representing the interactions between researcher and researched that will breathe new life into qualitative inquiries. I will attempt to flatten and shred, destabilise and disrupt our common-sense ideas about interview, including those held most sacred to the qualitative community, that of anonymity and confidentiality, as well as the privilege of the ‘transcript’ in re-presenting interview data.

  18. Comparing the utility of a modified Diagnostic Interview for Gambling Severity (DIGS) with the South Oaks Gambling Screen (SOGS) as a research screen in college students.

    Science.gov (United States)

    Fortune, Erica E; Goodie, Adam S

    2010-12-01

    The South Oaks Gambling Screen (SOGS) is compared in reliability to a modified version of the Diagnostic Interview for Gambling Severity (DIGS-S) for use as a pathological gambling (PG) screen in college students. Seventy-two undergraduates (83.3% male, mean age of 18.8) from the University of Georgia completed the measures, completing a longitudinal design with 3 sessions over a 2-month time period. The DIGS-S and the SOGS demonstrated good internal consistency over the 3 sessions, with Cronbach's Alphas ranging from 0.73 to 0.89, as well as strong concurrent validity, with correlations of .50 to .80 (Ps college-aged sample.

  19. A Study of Topic and Topic Change in Conversational Threads

    Science.gov (United States)

    2009-09-01

    ture or content of a relationship changes. The ability to detect topic change would support investigations of sexual predators, where a conversation...often starts out platonic and then turns sexual [21], as well as investigations into the techniques of recruitment for criminal or religious activity. If...conditions such as Autism or Attention Deficit Disorder be detected via long term studies of topics in individuals’ personal communications? 62 CHAPTER 6

  20. Diclofenac Topical (osteoarthritis pain)

    Science.gov (United States)

    Diclofenac topical gel (Voltaren) is used to relieve pain from osteoarthritis (arthritis caused by a breakdown of ... the knees, ankles, feet, elbows, wrists, and hands. Diclofenac topical liquid (Pennsaid) is used to relieve osteoarthritis ...

  1. Women's Health Topics

    Science.gov (United States)

    ... Information by Audience For Women Women's Health Topics Women's Health Topics Share Tweet Linkedin Pin it More ... State & Local Officials Consumers Health Professionals Science & Research Industry Scroll back to top Popular Content Home Latest ...

  2. Child Development & Behavior Topics

    Science.gov (United States)

    ... Your Child Topics Commentaries Featured Links Contact Us Child Development & Behavior Topics A B C D E F ... Seat Safety Carbon Monoxide Chewing Tobacco Child Care Child Development Milestones Child Development, What Do Grown-Ups Know ...

  3. Topics in Operator Theory

    CERN Document Server

    Ball, Joseph A; Helton, JWilliam; Rodman, Leiba; Spitkovsky, Iiya

    2010-01-01

    This is the first volume of a collection of original and review articles on recent advances and new directions in a multifaceted and interconnected area of mathematics and its applications. It encompasses many topics in theoretical developments in operator theory and its diverse applications in applied mathematics, physics, engineering, and other disciplines. The purpose is to bring in one volume many important original results of cutting edge research as well as authoritative review of recent achievements, challenges, and future directions in the area of operator theory and its applications.

  4. Interview, observation og dokumentanalyse

    DEFF Research Database (Denmark)

    Lindstrøm, Maria Duclos

    2014-01-01

    Kapitlet giver et eksempel på hvordan man indenfor en mixed methods-tradition (metodekombination) kan kombinere interviews, dokumentanalyse og etnografiske observationer.......Kapitlet giver et eksempel på hvordan man indenfor en mixed methods-tradition (metodekombination) kan kombinere interviews, dokumentanalyse og etnografiske observationer....

  5. Interviewing like a researcher

    DEFF Research Database (Denmark)

    Evald, Majbritt Rostgaard; Freytag, Per Vagn; Nielsen, Suna Løwe

    2018-01-01

    the transformation that neutral research methods go through, we consider an often-used method in business research, which researchers often become familiar with or have opinions about, which is the personal interview. The illustration of how the personal interview can be influenced by three different paradigms lays...

  6. Interviewing to Understand Strengths

    Science.gov (United States)

    Hass, Michael R.

    2018-01-01

    Interviewing clients about their strengths is an important part of developing a complete understanding of their lives and has several advantages over simply focusing on problems and pathology. Prerequisites for skillfully interviewing for strengths include the communication skills that emerge from a stance of not knowing, developing a vocabulary…

  7. An interview guide for clinicians to identify a young disabled person's motivation to work

    NARCIS (Netherlands)

    Faber, B. J. M.; Wind, H.; Frings-Dresen, M. H. W.

    2016-01-01

    The percentage of young people with disabilities who are employed is relatively low. Motivation is considered to be an important factor in facilitating or hindering their ability to obtain employment. We aimed to develop a topic list that could serve as an interview guide for professionals in

  8. Education for the 1980s and Beyond: An Interview with Carl Rogers.

    Science.gov (United States)

    Robinson, Edward H., III

    1985-01-01

    Presents an interview with Carl Rogers regarding education today and what it could be in the future. Discusses topics including politics and power, free choice versus conservatism, censorship, facilitators of learning, knowledge children need in today's world, and the changing society as it relates to humanistic education. (BH)

  9. The Archives of the History of American Psychology: An Interview with David B. Baker.

    Science.gov (United States)

    Prieto, Loreto R.

    2001-01-01

    Presents an interview with David B. Baker, Director of the Archives of the History of American Psychology. Covers topics such as: Baker's interest in the history of psychology, his work at the Archives of the History of American Psychology, and recommendations for teachers when addressing history in non-history courses. (CMK)

  10. Developing Student Critical Thinking Skills through Teaching Psychology: An Interview with Claudio S. Hutz.

    Science.gov (United States)

    McCarthy-Tucker, Sherri

    2001-01-01

    Presents an interview with Claudio S. Hutz, who is dean of Instituto de Psicologia at Universidade Federal do Rio Grande do Sul in Porto Alegre, Brazil, where he has been teaching psychology since 1977. Discusses topics such as teaching psychology in Brazil and developing critical thinking skills. (CMK)

  11. An Interview with Vahakn N. Dadrian: An Expert on the Armenian Genocide.

    Science.gov (United States)

    Cargas, Harry James

    1987-01-01

    In an interview format, Dadrian discusses his views on the Holocaust and the Armenian genocide. Analyzing topics such as "victimology," he demonstrates how outside countries and the victimized group actually facilitate the genocidal process. Concludes that world concern must be generated so that events similar to those in Armenia are not…

  12. Motivational Interviewing by School Nurses

    DEFF Research Database (Denmark)

    Bonde, Ane; Bentsen, Peter; Hindhede, Anette Lykke

    . An example is to use the BMI-curve as a tool to inform about the overweight, and to use it with the spirit of motivational interviewing for evoking the child’s own concern, as illustrated in the following quote: “I show the BMI-curve and the dot where the child is placed on the curve. The goal is to make......Title: Motivational Interviewing by School Nurses: Spirit, Techniques, and Dilemmas in the Prevention of Child Obesity Introduction : School nurses play a central role in school-based, preventive health services in Denmark (National Board of Health, 2011), and they may play an important role...... a prevention strategy targeting children with a high risk of obesity with an intervention conducted by school nurses using motivational interviewing.Motivational interviewing is a counselling method to bring about behavioural change (Miller and Rollnick 1995). Effect has been documented for a range of problem...

  13. Freshman Health Topics

    Science.gov (United States)

    Hovde, Karen

    2011-01-01

    This article examines a cluster of health topics that are frequently selected by students in lower division classes. Topics address issues relating to addictive substances, including alcohol and tobacco, eating disorders, obesity, and dieting. Analysis of the topics examines their interrelationships and organization in the reference literature.…

  14. The school textbook as a research topic in the history of education: notes to the geography text

    Directory of Open Access Journals (Sweden)

    Jorge Alejandro Aguirre Rueda

    2015-01-01

    Full Text Available The school textbook as memory space, ideological and pedagogical tool vector has emerged as a new piece of research for historians. Undervalued for a long time, today it brings critical information to understand the initial processes of socialization that took place within schools. One of them, indeed, has been the textbook of geography, which is shown as vehicle tool for many national messages about the territory and the population. It was evident that in Spain, Mexico, Guatemala, Colombia, Ecuador, Chile and Argentina such themes and uses were recurrent and provided similar services. However, it was found that the vast majority of historical studies are still overestimating the role of the textbook, as already denounced Alain Choppin.

  15. Topical steroid-damaged skin

    Directory of Open Access Journals (Sweden)

    Anil Abraham

    2014-01-01

    Full Text Available Topical steroids, commonly used for a wide range of skin disorders, are associated with side effects both systemic and cutaneous. This article aims at bringing awareness among practitioners, about the cutaneous side effects of easily available, over the counter, topical steroids. This makes it important for us as dermatologists to weigh the usefulness of topical steroids versus their side effects, and to make an informed decision regarding their use in each individual based on other factors such as age, site involved and type of skin disorder.

  16. Topical or oral administration with an extract of Polypodium leucotomos prevents acute sunburn and psoralen-induced phototoxic reactions as well as depletion of Langerhans cells in human skin

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez, S.; Pathak, M.A.; Fitzpatrick, T.B. [Massachusetts General Hospital, Harvard Medical School, Dept. of Dermatology, Boston, MA (United States); Cuevas, J. [Hospital Universitario de Guadalajara, Dept. of Pathology, Guadalajara (Spain); Villarrubia, V.G. [I.F. Cantabria SA, Medical Dept., Immunology Sect., Madrid (Spain)

    1997-12-31

    Sunburn, immune suppression, photo-aging, and skin cancers result from uncontrolled overexposure of human skin to solar ultraviolet radiation (UVR). Preventive measures, including photo-protection, are helpful and can be achieved by topical sun-screening agents. Polypodium leucotomos (PL) has been used for the treatment of inflammatory diseases and has shown some in vitro and in vivo immunomodulating properties. Its beneficial photo-protective effects in the treatment of vitiligo and its antioxidant properties encouraged us to evaluate in vivo the potentially useful photo-protective property of natural extract of PL after topical application or oral ingestion. Twenty-one healthy volunteers [either untreated or treated with oral psoralens (8-MOP or 5-MOP)] were enrolled in this study and exposed to solar radiation for evaluation of the following clinical parameters: immediate pigment darkening (IPD), minimal erythema dose (MED), minimal melanogenic dose (MMD), and minimal phototoxic dose (MPD) before and after topical or oral administration of PL. Immunohistochemical assessment of CD1a-expressing epidermal cells were also performed. PL was found to be photo-protective after topical application as well as oral administration. PL increased UV dose required for IPD (P<0.01), MED (P<0.001) and MPD (P<0.001). After oral administration of PL, MED increased 2.,8{+-}0.59 times and MPD increased 2.75{+-}0.5 and 6.8{+-}1.3 times depending upon the type of psoralen used. Immunohistochemical study revealed photo-protection of Langherhans cells by oral as well as topical PL. The observed photo-protective activities of oral or topical PL reveal a new avenue in examining the potentially useful field of systemic photo-protection and suggests that PL can be used as adjunct treatment and can make photochemotherapy and phototherapy possibly safe and effective when the control of cutaneous phototoxicity to PUVA or UVB is a limiting factor in such photo-therapies. (au). 50 refs.

  17. Drug compartmentalization as strategy to improve the physico-chemical properties of diclofenac sodium loaded niosomes for topical applications.

    Science.gov (United States)

    Tavano, Lorena; de Cindio, Bruno; Picci, Nevio; Ioele, Giuseppina; Muzzalupo, Rita

    2014-12-01

    The objective of this research was to study the effect of diclofenac sodium compartmentalization on the physico-chemical properties (such as size, drug entrapment efficiency and percutaneous permeation across rabbit skin) of niosomal vesicles used as carriers. Niosomes were prepared starting from nonionic commercial surfactants belonging to the class of Polysorbates and Pluronics: mixtures of Span 60/F127 and Tween 60/F127 at different ratios were used to obtain vesicles and all formulations were compared in terms of dimensions, morphology, polydispersity index and entrapment efficiency. Moreover, the enhancing effect of niosomes on the ex vivo percutaneous penetration of diclofenac sodium was investigated using Franz-type diffusion chambers and compared to that obtained by using the corresponding drug solution. Results demonstrated that niosomes were spherical and homogeneous in shape. Their size was found to be dependent on the hydrophile-lipophile balance of the surfactant mixture: increasing hydrophobicity resulted in smaller vesicles. Drug incorporation led to a significant variation in vesicle size dependently from the compartment in which the drug was located. The permeation of diclofenac from free solution used as control was found to be lower respect to that obtained for all niosomal formulations, that can be considered as percutaneous permeation enhancers. In particular, the results indicated that the highest cumulative amounts of diclofenac permeated across rabbit skin after 24 h were obtained by formulations in which the drug was located in the aqueous core.

  18. Synergistic Combination of Chitosan Acetate with Nanoparticle Silver as a Topical Antimicrobial: Efficacy against Bacterial Burn Infections ▿

    Science.gov (United States)

    Huang, Liyi; Dai, Tianhong; Xuan, Yi; Tegos, George P.; Hamblin, Michael R.

    2011-01-01

    Chitosan and nanoparticle silver are both materials with demonstrated antimicrobial properties and have been proposed singly or in combination as constituents of antimicrobial burn dressings. Here, we show that they combine synergistically to inhibit the in vitro growth of Gram-positive methicillin-resistant Staphylococcus aureus (MRSA) and Gram-negative bacteria (Pseudomonas aeruginosa, Proteus mirabilis, and Acinetobacter baumannii), as judged by bioluminescence monitoring and isobolographic analysis, and also produce synergistic killing after 30 min of incubation, as measured by a CFU assay. The hypothesized explanation involves chitosan-mediated permeabilization of bacterial cells, allowing better penetration of silver ions into the cell. A dressing composed of freeze-dried chitosan acetate incorporating nanoparticle silver was compared with a dressing of chitosan acetate alone in an in vivo burn model infected with bioluminescent P. aeruginosa. The survival rates of mice treated with silver-chitosan or regular chitosan or left untreated were 64.3% (P = 0.0082 versus regular chitosan and P = 0.0003 versus the control), 21.4%, and 0%, respectively. Most of the fatalities occurred between 2 and 5 days postinfection. Silver-chitosan dressings effectively controlled the development of systemic sepsis, as shown by blood culture. These data suggest that a dressing combining chitosan acetate with silver leads to improved antimicrobial efficacy against fatal burn infections. PMID:21502618

  19. Comparing clinical effects of photodynamic therapy as a novel method with topical corticosteroid for treatment of Oral Lichen Planus.

    Science.gov (United States)

    Bakhtiari, Sedigheh; Azari-Marhabi, Saranaz; Mojahedi, Seyyed Masoud; Namdari, Mahshid; Rankohi, Zahra Elmi; Jafari, Soudeh

    2017-12-01

    Oral lichen planus is an autoimmune disorder with several challenges in treatment. Photodynamic therapy has been proposed as a new treatment option for the disease. The present study compared the clinical effects of photodynamic therapy to dexamethasone mouthwash in the treatment of oral lichen planus lesions. In this randomized clinical trial, 30 patients with oral lichen planus were included.15 patients were treated with 5% methylene blue mediated photodynamic therapy using Fotosan device for 30s (630nm wavelength and 7.2-14.4J/cm 2 dose) for 4 sessions in the days 1, 4, 7, 14. In another group, the treatment was done on 15 patients by 0.5mg tab dexamethasone solution in 5cc water, rinsed 4 times in a day within two weeks. The sign score, symptoms scores (pain), clinical severity and treatment efficacy were measured at the days 15, 30, 60, 90 after beginning of the treatment. The results were subjected to Mann-whitney U test in both groups. No significant difference existed between the two modalities regarding the treatment efficacy index, sign score, symptom score and clinical severity on the 15, 30, 60 and 90 post-treatment days. Decreases in patient's symptoms were statistically significant in both groups. Photodynamic therapy was as effective as the dexamethasone mouth wash in the treatment of oral lichen planus. It could be used as a safe modality in the treatment of oral lichen planus lesions without identified side effects. Copyright © 2017 Elsevier B.V. All rights reserved.

  20. Psychotherapy as Stochastic Process: Fitting a Markov Chain Model to Interviews of Ellis and Rogers. University of Minnesota Office of Student Affairs Research Bulletin, Vol. 15, No. 18.

    Science.gov (United States)

    Lichtenberg, James W.; Hummel, Thomas J.

    This investigation tested the hypothesis that the probabilistic structure underlying psychotherapy interviews is Markovian. The "goodness of fit" of a first-order Markov chain model to actual therapy interviews was assessed using a x squared test of homogeneity, and by generating by Monte Carlo methods empirical sampling distributions of…

  1. Clinical application of oral form of ANGIPARSTM and in combination with topical form as a new treatment for diabetic foot ulcers: A randomized clinical trial

    Directory of Open Access Journals (Sweden)

    Bahrami A

    2008-04-01

    Full Text Available ANGIPARSTM is a new herbal extract which has been produced in oral, topical, and intravenous forms. The present article contains preliminary results of the study which was planned to evaluate the efficacy and safety of orally applied ANGIPARSTM and to compare it with the combination of oral and topical forms and also with conventional therapy in patients with diabetic ulcers of the lower extremities."nTwenty one patients with diabetic foot ulcers were divided into 3 groups. The first group received 100 mg of oral ANGIPARSTM twice a day for 6 weeks in addition to conventional therapies. In the second group, ANGIPARSTM gel 3% was added to the oral form of the same product besides the conventional therapies for the same period of time. Finally, in the third group which was considered as control, only conventional therapies were performed. The patients were followed for 6 weeks. Parameters such as granulation tissue formation, skin epithelization, and wound surface areas changes were analyzed to determine the effectiveness of the compound in wounds healing. Furthermore, drug safety was assessed by monitoring adverse events and by clinical and laboratory evaluations."nThe study data showed significant differences between the intervention and control groups with respect to efficacy and tolerability. In each intervention group, primary wound healings occurred following 2 weeks. Complete wound healing which was greater than 70% improvement in wounds surface areas was achieved in 83% and 100% of group 1 and group 2 participants, respectively after 6 weeks. On the other hand, at the same period of time, only 22.2% of patients in control group revealed complete healing. Therefore, ANGIPARSTM had significant positive effect in increasing the incidence of complete wound closure compared with control group (p = 0.042. However, our evaluations indicated that adding topical treatment with 3% gel once a day to the oral therapy with the same product did not make

  2. UV-curable gels as topical nail medicines:In vivo residence, anti-fungal efficacy and influence of gel components on their properties.

    Science.gov (United States)

    Kerai, L V; Hilton, S; Maugueret, M; Kazi, B B; Faull, J; Bhakta, S; Murdan, S

    2016-11-30

    UV-curable gels, used as nail cosmetics for their in vivo durability, were reported to be promising as topical nail medicines. Our first aim was thus to investigate whether such durability applies to drug-loaded formulations. This was found to be true. However, ethanol inclusion in the pharmaceutical formulation (to enable drug loading) reduced the in vivo residence. The second aim was therefore to determine any other effects of ethanol, and if ethanol could be avoided by the choice of monomers. Thus, three methacrylate monomers, ethyl methacrylate, isobornyl methacrylate and 2-hydroxyethyl methacrylate (HEMA) were selected, and their influence on the formulation properties were determined. Ethanol and the methacrylate monomer influenced some (but not all) of the formulation properties. The most significant was that HEMA could dissolve drug and enable the preparation of ethanol-free, drug-loaded formulations, which would benefit in vivo residence. The absence of ethanol reduced drug loading, release and ungual flux, but had no negative impact on the in vitro anti-fungal efficacy. Thus, judicious selection of gel components enabled the exclusion of ethanol. The long in vivo residence, little residual monomers, sufficient ungual permeation and in vitro anti-fungal activity of the gels indicates their potential as anti-onychomycotic topical medicines. Copyright © 2016 Elsevier B.V. All rights reserved.

  3. Etiske udfordringer når personer med tætte relationer interviewes samtidigt i samme rum – Et Integrativt review

    DEFF Research Database (Denmark)

    Voltelen, Barbara; Konradsen, Hanne; Østergaard, Birte

    contained relevant information about dyadic interviewing but only very subtle topics about ethics and 8 articles addressed both dyadic interviewing and ethical considerations. Findings were divided into three different types of ethical challenges for: 1. The researcher/interviewer. 2. The planning of joint...... interviews 3. Participants wellbeing Conclusion Ethical considerations’ doing joint interviews could include themes as; privacy and confidentiality, informed consent, harm, dual role and over-involvement, politics and power. Joint interview provides insight to shared accounts and communication patterns......Background Interviewing two interrelated persons (or more) at the same time poses different considerations than interviews with one person, among others due to the relation between the informants. Aim To provide an overview on ethical perspectives conducting joint interviews with interrelated...

  4. The origin of the universe as a topic to discuss the Nature of Science in High School

    OpenAIRE

    Guttmann, Gustavo Antonio Montenegro; Cefet-RJ, Uned, Nova Friburgo, RJ; Braga, Marco; CEFET-RJ, Rio de Janeiro, RJ

    2015-01-01

    This paper presents an educational activity in which the Nature of Science is discussed in the confrontation of two distinct theories about the origin of the universe. These activities were developed in a high school in Rio de Janeiro. These theories are divergent, one defending the universe as having a defined origin, the Big Bang, and the other an Eternal Universe. At the end of the activities it was possible to verify that the students developed a more complex vision of Science.  http:/...

  5. REVIEWS OF TOPICAL PROBLEMS: Waves in systems with cross-diffusion as a new class of nonlinear waves

    Science.gov (United States)

    Tsyganov, Mikhail A.; Biktashev, V. N.; Brindley, J.; Holden, A. V.; Ivanitsky, Genrikh R.

    2007-03-01

    Research on spatially extended excitable systems with cross-diffusion components is reviewed. Particular attention is given to the new phenomena of the quasi-soliton and half-soliton interaction of excitation waves, which are specific to such systems and occur along with the standard nonsoliton wave interaction that causes the waves to mutually annihilate. A correlation is shown to exist between interaction regimes and wave profile shapes. One example of a cross-diffusion system is population systems with taxes. Based on the mathematical models of and experimental work with bacterial populations, waves in excitable cross-diffusion systems can be identified as a new class of nonlinear waves.

  6. Computational mediation as factor of motivation and meaningful learning in education of sciences of 9th grade: astronomy topics

    Science.gov (United States)

    Da Silva, F. M.; Furtado, W. W.

    2012-10-01

    The main purpose of this study was to analyze the contribution of using hypertext and pedagogic mediation in search of a Meaningful Learning Process in Sciences. We investigate the usage of hypertext in the teaching and learning methods of Astronomy modules. A survey was conducted with students from the 9th grade of Primary School of a public school in the city of Goiânia, Goiás in Brazil. We have analyzed the possibilities that hypermedia can offer in the teaching and learning process, using as reference David Ausubel's Theory of Meaningful Learning. The study was divided into four phases: application of an initial questionnaire on students, development of didactic material (hypertext), six classes held in a computer lab with the use of hypermedia and a final questionnaire applied in the lab after classes. This research indicated that the use of hypertext linked to pedagogical mediation processes is seen as a motivational tool and has potential to foster to Meaningful Learning.

  7. Philosophical Hermeneutic Interviewing

    Directory of Open Access Journals (Sweden)

    Roxanne K. Vandermause PhD, RN

    2011-12-01

    Full Text Available This article describes, exemplifies and discusses the use of the philosophical hermeneutic interview and its distinguishing characteristics. Excerpts of interviews from a philosophical hermeneutic study are used to show how this particular phenomenological tradition is applied to research inquiry. The purpose of the article is to lay out the foundational background for philosophical hermeneutics in a way that clarifies its unique approach to interviewing and its usefulness for advancing health care knowledge. Implications for health care research and practice are addressed.

  8. 3D scanning and 3D printing as innovative technologies for fabricating personalized topical drug delivery systems.

    Science.gov (United States)

    Goyanes, Alvaro; Det-Amornrat, Usanee; Wang, Jie; Basit, Abdul W; Gaisford, Simon

    2016-07-28

    Acne is a multifactorial inflammatory skin disease with high prevalence. In this work, the potential of 3D printing to produce flexible personalised-shape anti-acne drug (salicylic acid) loaded devices was demonstrated by two different 3D printing (3DP) technologies: Fused Deposition Modelling (FDM) and stereolithography (SLA). 3D scanning technology was used to obtain a 3D model of a nose adapted to the morphology of an individual. In FDM 3DP, commercially produced Flex EcoPLA™ (FPLA) and polycaprolactone (PCL) filaments were loaded with salicylic acid by hot melt extrusion (HME) (theoretical drug loading - 2% w/w) and used as feedstock material for 3D printing. Drug loading in the FPLA-salicylic acid and PCL-salicylic acid 3D printed patches was 0.4% w/w and 1.2% w/w respectively, indicating significant thermal degradation of drug during HME and 3D printing. Diffusion testing in Franz cells using a synthetic membrane revealed that the drug loaded printed samples released printed as a nose-shape mask by FDM 3DP, but the PCL-salicylic acid filament was not. In the SLA printing process, the drug was dissolved in different mixtures of poly(ethylene glycol) diacrylate (PEGDA) and poly(ethylene glycol) (PEG) that were solidified by the action of a laser beam. SLA printing led to 3D printed devices (nose-shape) with higher resolution and higher drug loading (1.9% w/w) than FDM, with no drug degradation. The results of drug diffusion tests revealed that drug diffusion was faster than with the FDM devices, 229 and 291μg/cm(2) within 3h for the two formulations evaluated. In this study, SLA printing was the more appropriate 3D printing technology to manufacture anti-acne devices with salicylic acid. The combination of 3D scanning and 3D printing has the potential to offer solutions to produce personalised drug loaded devices, adapted in shape and size to individual patients. Copyright © 2016 Elsevier B.V. All rights reserved.

  9. National Health Interview Survey (NHIS) - National Cardiovascular Disease Surveillance Data

    Data.gov (United States)

    U.S. Department of Health & Human Services — 2001 forward. The National Health Interview Survey (NHIS) has monitored the health of the nation since 1957. NHIS data on a broad range of health topics are...

  10. Preparation of a solid-in-oil nanosuspension containing L-ascorbic acid as a novel long-term stable topical formulation.

    Science.gov (United States)

    Piao, Hongyu; Kamiya, Noriho; Cui, Fude; Goto, Masahiro

    2011-11-25

    L-Ascorbic acid (AA, vitamin C) easily decomposes into inactive compounds in aqueous solutions and this has limited its topical use. This work reports the preparation of a solid-in-oil nanosuspension (SONS) containing AA and validation of its basic storage stability. Although AA itself is water-soluble, it can readily be nanosuspended in squalane via complex formation involving a combination of sucrose erucate (i.e. lipophilic surfactant) and sucrose monolaureate (i.e. hydrophilic surfactant) to yield SONS with a very low moisture content (solution. Our results demonstrate that almost all the encapsulated AA (95.3%) was readily extracted from the SONS upon addition of medium-chain triglyceride, which offers the possibility of degrading the formulation phase using lipase. Finally, its storage stability study was investigated at 25°C over 90 days under protection from light. An aqueous solution containing AA was used as a control. Compared with the control, the SONS markedly increased the stability of AA due to its low moisture content and, thus, the potential usefulness SONSs as a novel long-term stable topical formulation of AA has been proved. Copyright © 2011 Elsevier B.V. All rights reserved.

  11. Mental Mechanisms for Topics Identification

    Directory of Open Access Journals (Sweden)

    Louis Massey

    2014-01-01

    Full Text Available Topics identification (TI is the process that consists in determining the main themes present in natural language documents. The current TI modeling paradigm aims at acquiring semantic information from statistic properties of large text datasets. We investigate the mental mechanisms responsible for the identification of topics in a single document given existing knowledge. Our main hypothesis is that topics are the result of accumulated neural activation of loosely organized information stored in long-term memory (LTM. We experimentally tested our hypothesis with a computational model that simulates LTM activation. The model assumes activation decay as an unavoidable phenomenon originating from the bioelectric nature of neural systems. Since decay should negatively affect the quality of topics, the model predicts the presence of short-term memory (STM to keep the focus of attention on a few words, with the expected outcome of restoring quality to a baseline level. Our experiments measured topics quality of over 300 documents with various decay rates and STM capacity. Our results showed that accumulated activation of loosely organized information was an effective mental computational commodity to identify topics. It was furthermore confirmed that rapid decay is detrimental to topics quality but that limited capacity STM restores quality to a baseline level, even exceeding it slightly.

  12. National Health Interview Survey

    Data.gov (United States)

    U.S. Department of Health & Human Services — The National Health Interview Survey (NHIS) is the principal source of information on the health of the civilian noninstitutionalized population of the United States...

  13. Interview with Henry Jenkins

    Directory of Open Access Journals (Sweden)

    TWC Editor

    2008-09-01

    Full Text Available An interview with Henry Jenkins focussing on Transformative Works and Cultures (TWC, the Organization for Transformative Works (OTW, and Jenkins' academic research into fan and participatory cultures.

  14. Topics on continua

    CERN Document Server

    Macias, Sergio

    2005-01-01

    Specialized as it might be, continuum theory is one of the most intriguing areas in mathematics. However, despite being popular journal fare, few books have thoroughly explored this interesting aspect of topology. In Topics on Continua, Sergio Macías, one of the field's leading scholars, presents four of his favorite continuum topics: inverse limits, Jones's set function T, homogenous continua, and n-fold hyperspaces, and in doing so, presents the most complete set of theorems and proofs ever contained in a single topology volume. Many of the results presented have previously appeared only in research papers, and some appear here for the first time. After building the requisite background and exploring the inverse limits of continua, the discussions focus on Professor Jones''s set function T and continua for which T is continuous. An introduction to topological groups and group actions lead to a proof of Effros''s Theorem, followed by a presentation of two decomposition theorems. The author then offers an...

  15. Parental response to a letter reporting child overweight measured as part of a routine national programme in England: results from interviews with parents

    Directory of Open Access Journals (Sweden)

    Lawrence A. Nnyanzi

    2016-08-01

    Full Text Available Abstract Background Rising rates of childhood obesity have become a pressing issue in public health, threatening both the mental and physical well-being of children. Attempts to address this problem are multifaceted, and in England include the National Child Measurement Programme (NCMP which assesses weight status in English primary school children in reception class (aged 4–5 and in year 6 (aged 10–11, with results being sent out to parents. However the effectiveness and impact of this routine parental feedback has yet to be fully understood. This paper reports one component of a mixed methods study undertaken in North East England, examining the impact of the feedback letters on parents’ understanding and feelings about their child’s weight status and whether or not this seemed likely to lead to behaviour change. Methods One-to-one semi-structured interviews (n = 16 were conducted with a sample of parents/guardians after they had received their child’s weight results letter. Eight parents/guardians were sub-sampled from the group whose child had been indicated to be overweight or obese and eight were from the group whose child had been indicated to be of ideal weight status. Interviews were conducted until data saturation was reached for both groups. Results The reactions of parents/guardians whose children were identified as being overweight followed a sequence of behaviours ranging from shock, disgust with the programme, through denial and self-blame to acceptance, worry and intention to seek help. On the other hand, the reaction of parents/guardians whose children were identified as being ideal weight ranged from relief, pleasure and happiness through affirmation and self-congratulation to ‘othering’. Conclusions Whilst overweight and obesity is often portrayed as a medical condition, parents/guardians see it as deeply rooted in their social lives and not in health terms. Parents believe that the causes of overeating and

  16. Motivational Interviewing and Rehabilitation Counseling Practice

    Science.gov (United States)

    Wagner, C. C.; McMahon, B. T.

    2004-01-01

    This article explores commonalities between rehabilitation counseling and the counseling approach known as motivational interviewing. Motivational interviewing is an empirically supported, clientcentered, directive counseling approach designed to promote client motivation and reduce motivational conflicts and barriers to change. The underpinnings…

  17. Interview with Peter Jenni

    CERN Multimedia

    PH Newsletter

    2013-01-01

    Peter Jenni, former spokesperson of the ATLAS Collaboration, discusses the challenges and satisfactions from his long-standing career in high-energy physics in this month’s PH Newsletter.   Peter Jenni. Following a long career at CERN that dates back to 1970 (ranging from Summer Student to Fellow and to Staff), Peter Jenni recently retired after about 40 years marked by exciting discoveries (from the first two-photon production of eta-prime at SPEAR to the Higgs boson at the LHC). Peter was involved in the LHC from its very beginnings and was spokesperson of the ATLAS Collaboration until February 2009. Peter Jenni will continue working with ATLAS as a guest scientist with the Albert-Ludwigs-University Freiburg, and when he's not travelling he still spends most of his time in his office in Building 40, where he met with interviewer Panos Charitos. Panos Charitos: When did you first arrive to CERN? Peter Jenni: I first came to CERN as a Summer Student in ...

  18. Interview with Lenny Kaye

    Directory of Open Access Journals (Sweden)

    Cristina Garrigós

    2012-12-01

    Full Text Available Lenny Kaye has been Patti Smith’s long term guitarist, friend and collaborator, ever since they first began together in the early 1970s. He grew up between New York and New Jersey, graduating in American History from Rutgers University, where he later taught a course in the Department of American Studies on the History of American Rock, which became famous because of the large number of students who wanted to enroll in it. A very prolific writer and musician, he has produced an important number of records, as well as collaborated with numerous music magazines. He is the author of two books, Waylon Jennings: An Autobiography (1996 and You Call it Madness, The Sensuous Song of the Croon (2004. Nuggets (1972, his anthology of 60s garage music, is famous for defining the genre. This interview took place when he was visiting Spain in November 2012 with the Patti Smith Group. In it, we discussed the New York scene of the 70s, music, literature, drugs, politics, and many other things.

  19. Usefulness of pressure-sensitive adhesives as a pretreatment material before application of topical drug formulations and a peeling tape for excess stratum corneum layers.

    Science.gov (United States)

    Kikuchi, Keisuke; Todo, Hiroaki; Sugibayashi, Kenji

    2014-01-01

    Two unique pressure-sensitive adhesive (PSA) tapes (PSA-A, -B) with different adhesive properties of commercial PSAs were prepared and evaluated for their usefulness as a pretreatment material prior to the application of transdermal therapeutic systems or topical drug formulations and also as a peeling agent against excess layers of the stratum corneum. In the present study, in vitro permeation experiments were conducted using vertical type diffusion cells and excised hairless rat or porcine skin from which the stratum corneum had been stripped several times with PSAs. The results obtained revealed that PSA-A and -B had higher stripping or peeling effects than those of the marketed PSAs. Marked changes were observed in skin barrier function before and after stripping using PSAs, and the enhancement effect on the skin permeation of drugs achieved by stripping the stratum corneum was markedly different between the PSAs. PSA-A, in particular, markedly improved skin permeation and the skin concentration of topically applied chemical compounds because it removed many layers of the stratum corneum when skin was stripped only a few times. In contrast, when PSA-B was used to pretreat the skin surface, the extent of skin permeation and concentration of drugs was safely increased because only a few layers of the stratum corneum were removed, even with repeated stripping. The enhancement effect achieved by PSA-B was not as high as that by PSA-A. Thus, stripping with PSA-A can be used as a penetration enhancement tool, whereas PSA-B can be used as a peeling material against excess layers of the stratum corneum.

  20. Using Joint Interviews to Add Analytic Value.

    Science.gov (United States)

    Polak, Louisa; Green, Judith

    2016-10-01

    Joint interviewing has been frequently used in health research, and is the subject of a growing methodological literature. We review this literature, and build on it by drawing on a case study of how people make decisions about taking statins. This highlights two ways in which a dyadic approach to joint interviewing can add analytic value compared with individual interviewing. First, the analysis of interaction within joint interviews can help to explicate tacit knowledge and to illuminate the range of often hard-to-access resources that are drawn upon in making decisions. Second, joint interviews mitigate some of the weaknesses of interviewing as a method for studying practices; we offer a cautious defense of the often-tacit assumption that the "naturalness" of joint interviews strengthens their credibility as the basis for analytic inferences. We suggest that joint interviews are a particularly appropriate method for studying complex shared practices such as making health decisions. © The Author(s) 2015.

  1. Human-competitive automatic topic indexing

    CERN Document Server

    Medelyan, Olena

    2009-01-01

    Topic indexing is the task of identifying the main topics covered by a document. These are useful for many purposes: as subject headings in libraries, as keywords in academic publications and as tags on the web. Knowing a document’s topics helps people judge its relevance quickly. However, assigning topics manually is labor intensive. This thesis shows how to generate them automatically in a way that competes with human performance. Three kinds of indexing are investigated: term assignment, a task commonly performed by librarians, who select topics from a controlled vocabulary; tagging, a popular activity of web users, who choose topics freely; and a new method of keyphrase extraction, where topics are equated to Wikipedia article names. A general two-stage algorithm is introduced that first selects candidate topics and then ranks them by significance based on their properties. These properties draw on statistical, semantic, domain-specific and encyclopedic knowledge. They are combined using a machine learn...

  2. Client interpersonal impacts as mediators of long-term outcome in cognitive-behavioral therapy integrated with motivational interviewing for generalized anxiety disorder.

    Science.gov (United States)

    Constantino, Michael J; Romano, Felicia M; Coyne, Alice E; Westra, Henny A; Antony, Martin M

    2017-03-24

    A recent trial of generalized anxiety disorder treatment (Westra, H. A., Constantino, M. J., & Antony, M. M. (2016). Integrating Motivational Interviewing With Cognitive-Behavioral Therapy for Severe Generalized Anxiety Disorder: An Allegiance-Controlled Randomized Clinical Trial. Journal of Consulting and Clinical Psychology, 84, 768-782. doi: 10.1037/ccp0000098 ) revealed that cognitive-behavioral therapy (CBT) integrated with motivational interviewing (MI) outperformed CBT alone across a 12-month follow up. The present study examined whether this treatment effect was mediated by MI-CBT clients engaging over time in during-session interpersonal behaviors reflecting more friendly dominance, or agentic actions, and less friendly submissiveness (FS), or trustingly compliant actions both theory-specific MI mechanisms. Clients received 15 sessions of MI-CBT (n = 42) or CBT alone (n = 43). Therapists rated client interpersonal behavior following five sessions, and clients rated their worry at baseline, each session, and 6- and 12-month follow up. Mediator and outcome variables were derived from multilevel models. Mediation was tested using a bootstrapping procedure. There was a significant indirect effect for FS. As expected, CBT clients evidenced greater increases in FS than MI-CBT clients, which in turn, though unexpectedly, related to lower 12-month worry. However, long-term CBT outcomes remained inferior to MI-CBT outcomes even with CBT clients'greater increase in FS. Results suggest that CBT outcomes are more positive when clients trustingly comply; however, MI-CBT remained superior, but for as yet unexplained reasons. Clinical or methodological significance of this article: The findings highlight the clinical importance of GAD clients becoming more friendly dominant in the therapy relationship irrespective of whether they received CBT or integrative MI-CBT. Moreover, it seems clinically indicated to incorporate MI spirit and techniques into CBT when

  3. The limitations of language: male participants, stoicism, and the qualitative research interview.

    Science.gov (United States)

    Affleck, William; Glass, Kc; Macdonald, Mary Ellen

    2013-03-01

    The semistructured, open-ended interview has become the gold standard for qualitative health research. Despite its strengths, the long interview is not well suited for studying topics that participants find difficult to discuss, or for working with those who have limited verbal communication skills. A lack of emotional expression among male research participants has repeatedly been described as a significant and pervasive challenge by health researchers in a variety of different fields. This article explores several prominent theories for men's emotional inexpression and relates them to qualitative health research. The authors argue that investigators studying emotionally sensitive topics with men should look beyond the long interview to methods that incorporate other modes of emotional expression. This article concludes with a discussion of several such photo-based methods, namely, Photovoice, Photo Elicitation, and Visual Storytelling.

  4. Topics in atomic physics

    CERN Document Server

    Burkhardt, Charles E

    2006-01-01

    The study of atomic physics propelled us into the quantum age in the early twentieth century and carried us into the twenty-first century with a wealth of new and, in some cases, unexplained phenomena. Topics in Atomic Physics provides a foundation for students to begin research in modern atomic physics. It can also serve as a reference because it contains material that is not easily located in other sources. A distinguishing feature is the thorough exposition of the quantum mechanical hydrogen atom using both the traditional formulation and an alternative treatment not usually found in textbooks. The alternative treatment exploits the preeminent nature of the pure Coulomb potential and places the Lenz vector operator on an equal footing with other operators corresponding to classically conserved quantities. A number of difficult to find proofs and derivations are included as is development of operator formalism that permits facile solution of the Stark effect in hydrogen. Discussion of the classical hydrogen...

  5. Interview with Gavin Butt

    DEFF Research Database (Denmark)

    Hasse Jørgensen, Stina; Alexandra Sofie, Jönsson

    2008-01-01

    We have interviewed Gavin Butt about his research interest in the cross-field between performance and performativity in the visual arts: queer theory, queer cultures and their histories, post-second world war U.S. art, contemporary art and critical theory.......We have interviewed Gavin Butt about his research interest in the cross-field between performance and performativity in the visual arts: queer theory, queer cultures and their histories, post-second world war U.S. art, contemporary art and critical theory....

  6. Interviews with information receivers

    International Nuclear Information System (INIS)

    1997-11-01

    The Waste Policy Institute (WPI), through a cooperative agreement with the U.S. Department of Energy's (DOE) Office of Science and Technology (OST), conducted telephone interviews with people who requested OST publications to better understand why they wanted information from OST, how they used the information, and whether the information met their needs. Researchers selected 160 people who requested one of the two OST publications-either the Technology Summary Series (Rainbow Books) or the Initiatives newsletter. Of the 160 selected, interviewers spoke with 79 people nationwide representing six stakeholder audience categories

  7. Nonadherence to psoriasis medication as an outcome of limited coping resources and conflicting goals: findings from a qualitative interview study with people with psoriasis.

    Science.gov (United States)

    Thorneloe, R J; Bundy, C; Griffiths, C E M; Ashcroft, D M; Cordingley, L

    2017-03-01

    Medication nonadherence is known to limit the effectiveness of available therapies; however, little is known specifically about medication adherence in people with psoriasis. Medicines self-management can feel onerous to those with dermatological conditions due to the nature of therapies prescribed and many individuals with psoriasis experience additional challenges such as physical and psychological comorbidities that place significant additional demands on individuals and may undermine adherence. Viewing nonadherence to medication as an outcome of limited personal coping resources and conflicting goals may help to explain medication nonadherence. To explore individuals' perspectives of their psoriasis, medication and its management. Twenty people with psoriasis were recruited from community samples in England and interviewed in-depth about their perceptions of their psoriasis, medication, and adherence to medication and self-management advice. Data were analysed using Framework Analysis. Participants reported that adhering to recommended treatment regimens conflicted with the management of the physical and psychological demands of living with psoriasis. Medication usage was viewed as a source of unresolved emotional distress and, for some, resulted in poor self-reported adherence, which included medication overuse, underuse and rejection of prescribed therapies. Perceived lack of engagement by clinicians with participants' self-management difficulties was viewed as an additional source of stress and distress. Adhering to medication in psoriasis can be an additional source of considerable emotional distress. We interpreted some episodes of nonadherence to psoriasis medication as rational attempts by individuals to minimize distress and to gain control over their life. © 2016 The Authors. British Journal of Dermatology published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists.

  8. RECOMMENDATIONS FOR INTERVIEWERS CONDUCTING SOCIOLOGICAL SURVEYS: THE USE OF THE PSYCHOTYPES THEORY AND ANALYSIS OF RESPONDENTS’ NONVERBAL REACTIONS

    Directory of Open Access Journals (Sweden)

    Ж В Пузанова

    2018-12-01

    Full Text Available The quality of sociological data is the problem that cannot lose relevance in the works of methodologists and practicing sociologists for decades. Procedures and techniques for the improvement of the quality of information for all type of survey methods are developing. The purpose of the article is to inform the interviewers conducting semi-structured or unstructured interviews of the recommendations developed on the basis of the theory of psychotypes (by V.V. Ponomarenko. This technology will allow to improve the quality of sociological data. Identification of the psychotype of the respondent and his emotional reactions to different sensitive topics during the interview are the basis of this technology. Emotional reactions can be traced by nonverbal cues (facial expressions, gestures and poses and interpreted by the technology of the analysis of nonverbal reactions developed and approved earlier. During the multi-stage experiment, the reactions significant in the course of interview were traced and analyzed - irritation, surprise, sadness, contempt, joy, fear, disgust, stress/discomfort, doubt/indecision, manifestations of mental processes. At the first phase, representatives of ‘ideal types’ of each psychotype were selected by an abridged psychological test and external diagnostics based on sensitive topics. As a result, the recommendations for a semi-structured interview were formulated. To use this technique, it is necessary to test an interviewee before the interview by the abridged psychological technique (in case there are doubts after the visual diagnostics. According to the psychotype the interviewer pays attention to the sensitive topics of the in-terview, and during the interview can reformulate the open-ended questions to reduce the sensitivity of significant topics for each respondent.

  9. An Interview with Howard Gardner.

    Science.gov (United States)

    Kirschenbaum, Robert J.

    1990-01-01

    This interview with Howard Gardner, author of such books as "The Theory of Multiple Intelligences" and professor of education, addresses such concerns as the nature of cognitive science; parenting; the importance of human relationships in education; the meaning of "intelligence,""talent,""and giftedness";…

  10. TopicPanorama: A Full Picture of Relevant Topics.

    Science.gov (United States)

    Wang, Xiting; Liu, Shixia; Liu, Junlin; Chen, Jianfei; Zhu, Jun; Guo, Baining

    2016-12-01

    This paper presents a visual analytics approach to analyzing a full picture of relevant topics discussed in multiple sources, such as news, blogs, or micro-blogs. The full picture consists of a number of common topics covered by multiple sources, as well as distinctive topics from each source. Our approach models each textual corpus as a topic graph. These graphs are then matched using a consistent graph matching method. Next, we develop a level-of-detail (LOD) visualization that balances both readability and stability. Accordingly, the resulting visualization enhances the ability of users to understand and analyze the matched graph from multiple perspectives. By incorporating metric learning and feature selection into the graph matching algorithm, we allow users to interactively modify the graph matching result based on their information needs. We have applied our approach to various types of data, including news articles, tweets, and blog data. Quantitative evaluation and real-world case studies demonstrate the promise of our approach, especially in support of examining a topic-graph-based full picture at different levels of detail.

  11. Poetry as a “Humane Enterprise”: Interview with Eavan Boland on the Occasion of the 50th Anniversary of her Literary Career

    Directory of Open Access Journals (Sweden)

    Pilar Villar-Argáiz

    2012-03-01

    Full Text Available Few poets have written so eloquently as Eavan Boland about the silencing of women’s voices in the literary and historical past. Throughout her prolific career as a poet she has defended a new Irish aesthetics rooted in everyday life, a subject matter not particularly sanctioned by the Irish poetic tradition, which chiefly revolved around the traditional subject matter of the heroic, dismissing the ordinary world of women as a trivial issue. In blurring the borders of the political and the private realms in Ireland, Boland has renewed the conventions of the public poem, the domestic poem and the nature poem. It is now clear that, after ten volumes of poetry, she has founded a new Irish literary tradition of her own recognisably different from that of poets such as W.B. Yeats, one of her fondest male precursors. From this perspective, she is not only a constituent part of contemporary Irish poetry but also an essential voice of worldwide literature in English. The recent publication of A Journey with Two Maps (New York and London: Norton, 2011 again evinces how her strong voice has asserted itself above the echoes of her male literary predecessors. In this new prose book, Boland reflects on the different ‘maps’ she has followed on her journey as a woman poet. Some maps are dictated by the poetic past and the inherited craft; others by subversion and innovation. But Boland has not only been a traveler in search of accurate maps; she is also, at this stage, inevitably and unquestionably, a map-maker herself, a cartographer whose work has provided guiding signposts for younger women poets in the difficult task of overcoming what she defines in this interview as the “aching silence at the center of a national literature”. Interestingly, although Boland now enjoys critical acclaim among readers and writers, she never enacts that authority in poetry. An idiosyncratic feature of her work is the powerless stance taken in her writing to

  12. Topics in mathematical biology

    CERN Document Server

    Hadeler, Karl Peter

    2017-01-01

    This book analyzes the impact of quiescent phases on biological models. Quiescence arises, for example, when moving individuals stop moving, hunting predators take a rest, infected individuals are isolated, or cells enter the quiescent compartment of the cell cycle. In the first chapter of Topics in Mathematical Biology general principles about coupled and quiescent systems are derived, including results on shrinking periodic orbits and stabilization of oscillations via quiescence. In subsequent chapters classical biological models are presented in detail and challenged by the introduction of quiescence. These models include delay equations, demographic models, age structured models, Lotka-Volterra systems, replicator systems, genetic models, game theory, Nash equilibria, evolutionary stable strategies, ecological models, epidemiological models, random walks and reaction-diffusion models. In each case we find new and interesting results such as stability of fixed points and/or periodic orbits, excitability...

  13. A brief motivational interviewing as an adjunct to periodontal therapy-A potential tool to reduce relapse in oral hygiene behaviours. A three-year study.

    Science.gov (United States)

    Stenman, J; Wennström, J L; Abrahamsson, K H

    2018-05-01

    To evaluate (ii) whether inclusion of a single motivational interviewing (MI) session, as an adjunct to periodontal therapy, might be beneficial for preventing relapse in oral hygiene behaviours among patients treated for chronic periodontitis and (ii) whether individual and clinical characteristics can be of predictive value for retention of sufficient oral hygiene behaviours. This 3-year follow-up of a previously reported randomized controlled trial (RCT) study of 6-month duration included 26 patients. Patients in the test group had received one MI session by a clinical psychologist before initiation of the periodontal treatment. Otherwise, all patients followed the same treatment protocol for conventional educational intervention and non-surgical periodontal therapy. Efficacy variables assessed for evaluation of the standard of self-performed periodontal infection control were marginal bleeding index (MBI; primary efficacy variable) and plaque score (PI). The patterns of change in MBI and PI scores were similar for test and control groups over the observation period. At 3 years, both groups showed a desirable mean full-mouth MBI of 15%, a figure that was comparable to that at the short-term evaluation after active periodontal treatment. The post-treatment MBI was the only variable identified as a predictor of retained adequate oral hygiene behaviours. A single MI session as an adjunct to conventional periodontal therapy could not be proven to be of long-term beneficial additive effect with regard to prevention of relapse in oral hygiene behaviour. Desirable standard of self-performed infection control after active periodontal treatment predicted the retention of sufficient oral hygiene behaviour over time. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  14. Induction interview form in EDH

    CERN Multimedia

    Information technology Department, AIS (Administrative Information Services) Group

    2007-01-01

    As part of the efforts to rationalise administrative procedures, the IT and HR Departments have developed a new EDH form for induction interviews, which can be accessed using the link below. In accordance with Administrative Circular No. 2 ('Recruitment, Appointment and possible developments regarding the contractual position of Staff Members', Rev. 3), the work and training objectives to be achieved during the probation period shall be specified in writing to all new staff members during an induction interview. The interview shall take place between the new staff member and his supervisor within six weeks of his taking up his duties at the latest. https://edh.cern.ch/Document/MAPS/Induction1) (or from the EDH desktop, by clicking on 'Other Tasks' and going to the 'HR & Training' heading) Please note that this form is to be used exclusively for new staff members. A separate EDH form will be developed for fellows.Information technology Department, AIS (Administrative Information Services) Group Human Re...

  15. Podcast - Interview with Anna Sfard

    DEFF Research Database (Denmark)

    2006-01-01

    During the 14th - 17th of November PhD Students and researchers from e-learning lab attended a PhD course called "Perspectives on Identity in Learning and Education Research". This course was co-organised by three local doctoral schools; The International Doctoral school of Technology and Science......, The Doctoral School of Human Centered Informatics (HCI) and The Doctoral school of Education, Learning and Philosophy. During the course Thomas Ryberg had the opportunity to interview the invited guest speakers about their views on the notion of identity within learning and educational research. The first...... interview was with Anna Sfard who at present holds a joint appointment in Michigan State University in US (as Lappan-Phillips-Fitzgerald Professor of Mathematics Education) and in the University of Haifa, Israel. During the interview Anna talks about her research on identity and two metaphors on learning...

  16. Induction interview form in EDH

    CERN Multimedia

    Information technology Department, AIS (Administrative Information Services) Group,

    2007-01-01

    As part of the efforts to rationalise administrative procedures, the IT and HR Departments have developed a new EDH form for induction interviews, which can be accessed using the link below. In accordance with Administrative Circular No. 2 ('Recruitment, Appointment and possible developments regarding the contractual position of Staff Members', Rev. 3), the work and training objectives to be achieved during the probation period shall be specified in writing to all new staff members during an induction interview. The interview shall take place between the new staff member and his supervisor within six weeks of him taking up his duties at the latest. https://edh.cern.ch/Document/MAPS/Induction (or from the EDH desktop, by clicking on 'Other Tasks' and going to the 'HR & Training' heading) Please note that this form is to be used exclusively for new staff members. A separate EDH form will be developed for fellows. Information technology Department, AIS (Administrative Information Services) Group Human...

  17. Interviewing the moderator

    DEFF Research Database (Denmark)

    Traulsen, Janine Morgall; Almarsdóttir, Anna Birna; Björnsdóttir, Ingunn

    2004-01-01

    a concrete example of its use in a recently completed research project. They discuss several advantages of the interview, among them that it provides information about group interaction and participant behavior, and furnishes additional data on what is discussed when the tape recorder is turned off....

  18. Interview with Srinivasa Varadhan

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 17; Issue 9. Interview with Srinivasa Varadhan. S Varadhan R Sujatha. Face to Face Volume 17 Issue 9 September 2012 pp 903-912. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/017/09/0903-0912 ...

  19. Interview with Steve Parks

    Science.gov (United States)

    Hitchcock, Jennifer

    2016-01-01

    Jennifer Hitchcock interviews community activist and director of Syracuse University's Composition and Cultural Rhetoric doctoral program, Steve Parks. They discuss Parks's working-class background, career path, influences, and activism. Parks also considers the direction of the field of composition and rhetoric and expresses optimism for the…

  20. Interview with Christine Franklin

    Science.gov (United States)

    Rossman, Allan; Franklin, Christine

    2013-01-01

    Chris Franklin is Senior Lecturer, Undergraduate Coordinator, and Lothar Tresp Honoratus Honors Professor of Statistics at the University of Georgia. She is a Fellow of the American Statistical Association and received the USCOTS Lifetime Achievement Award in 2013. This interview took place via email on August 16, 2013-October 9, 2013. Franklin…

  1. The Unstructured Clinical Interview

    Science.gov (United States)

    Jones, Karyn Dayle

    2010-01-01

    In mental health, family, and community counseling settings, master's-level counselors engage in unstructured clinical interviewing to develop diagnoses based on the "Diagnostic and Statistical Manual of Mental Disorders" (4th ed., text rev.; "DSM-IV-TR"; American Psychiatric Association, 2000). Although counselors receive education about…

  2. The psychiatric interview

    DEFF Research Database (Denmark)

    Frederiksen, Julie Elisabeth Nordgaard; Sass, Louis A; Parnas, Josef

    2012-01-01

    faithful distinctions in this particular domain, we need a more adequate approach, that is, an approach that is guided by phenomenologically informed considerations. Our theoretical discussion draws upon clinical examples derived from structured and semi-structured interviews. We conclude that fully...

  3. Interview with Srinivasa Varadhan

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 17; Issue 9. Interview with Srinivasa Varadhan. S Varadhan R Sujatha. Face to Face Volume 17 Issue 9 September 2012 pp 903-912. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/reso/017/09/0903-0912 ...

  4. Health, colonialism, and development: an interview with historian Randall Packard. Interview by Gilberto Hochman, Jaime Benchimol and Magali Romero Sá.

    Science.gov (United States)

    Packard, Randall

    2011-06-01

    Interview with Randall Packard, William H. Welch Professor of the History of Medicine at The Johns Hopkins University and co-editor of the Bulletin of the History of Medicine. Speaking about his academic career, his activities as an editor, and his main works, Professor Packard addresses the topics of health and disease in the history of Africa; the relation between disease eradication programs and the ideology of development; the malaria eradication program; medicine, international health, and colonialism; academic production in the history of medicine in the Anglo-Saxon world; and the dynamics of scientific publishing in the field of the history of medicine.

  5. Skype interviewing: the new generation of online synchronous interview in qualitative research.

    Science.gov (United States)

    Janghorban, Roksana; Latifnejad Roudsari, Robab; Taghipour, Ali

    2014-01-01

    The most commonly used method for data collection in qualitative research is interviewing. With technology changes over the last few decades, the online interview has overcome time and financial constraints, geographical dispersion, and physical mobility boundaries, which have adversely affected onsite interviews. Skype as a synchronous online service offers researchers the possibility of conducting individual interviews as well as small focus groups, comparable to onsite types. This commentary presents the characteristics of the Skype interview as an alternative or supplemental choice to investigators who want to change their conventional approach of interviewing.

  6. PREFACE: CEWQO Topical Issue CEWQO Topical Issue

    Science.gov (United States)

    Bozic, Mirjana; Man'ko, Margarita

    2009-09-01

    This topical issue of Physica Scripta collects selected peer-reviewed contributions based on invited and contributed talks and posters presented at the 15th Central European Workshop on Quantum Optics (CEWQO) which took place in Belgrade 29 May-3 June 2008 (http://cewqo08.phy.bg.ac.yu). On behalf of the whole community took place in Belgrade 29 May-3 June 2008 (http://cewqo08.phy.bg.ac.yu, cewqo08.phy.bg.ac.yu). On behalf of the whole community of the workshop, we thank the referees for their careful reading and useful suggestions which helped to improve all of the submitted papers. A brief description of CEWQO The Central European Workshop on Quantum Optics is a series of conferences started informally in Budapest in 1992. Sometimes small events transform into important conferences, as in the case of CEWQO. Professor Jozsef Janszky, from the Research Institute of Solid State Physics and Optics, is the founder of this series. Margarita Man'ko obtained the following information from Jozsef Janszky during her visit to Budapest, within the framework of cooperation between the Russian and Hungarian Academies of Sciences in 2005. He organized a small workshop on quantum optics in Budapest in 1992 with John Klauder as a main speaker. Then, bearing in mind that a year before Janszky himself was invited by Vladimir Buzek to give a seminar on the same topic in Bratislava, he decided to assign the name 'Central European Workshop on Quantum Optics', considering the seminar in Bratislava to be the first workshop and the one in Budapest the second. The third formal workshop took place in Bratislava in 1993 organized by Vladimir Buzek, then in 1994 (Budapest, by Jozsef Janszky), 1995 and 1996 (Budmerice, Slovakia, by Vladimir Buzek), 1997 (Prague, by Igor Jex), 1999 (Olomouc, Czech Republic, by Zdenek Hradil), 2000 (Balatonfüred, Hungary, by Jozsef Janszky ), 2001 (Prague, by Igor Jex), 2002 (Szeged, Hungary, by Mihaly Benedict), 2003 (Rostock,Germany, by Werner Vogel and

  7. Interview with Andrew Dalby

    OpenAIRE

    Mac Con Iomaire, Máirtín

    2016-01-01

    Andrew Dalby (born 1947 in Liverpool) is an English linguist, translator and historian and author of numerous articles and several books on a wide range of topics including food history, language, and Classical texts. Dalby studied Latin, French and Greek at the Bristol Grammar School and University of Cambridge. Here he also studied Romance languages and linguistics, earning a bachelor's degree in 1970. Dalby worked for fifteen years at Cambridge University Library, eventually specialising i...

  8. A Reflexive Inquiry on the Effect of Place on Research Interviews Conducted With Homeless and Vulnerably Housed Individuals

    Directory of Open Access Journals (Sweden)

    John Ecker

    2016-11-01

    Full Text Available In this study, I utilized a process of reflexivity to examine the effect of location when conducting interviews with homeless and vulnerably housed individuals. The impact of interview locations has received limited attention in the community psychology literature, despite the majority of research being community-based. The study provides insights into the challenges, benefits, and power relations involved in selecting a research interview site and in conducting interviews. Personal journal entries were used to analyze the effect of location on the participants and I as the researcher, through a comparative analysis of interviews conducted in the community and a research center. Results demonstrate that interview locations hold great amounts of power and can provide the opportunity for holistic understandings of research topics. Lessons learned and methodological implications are discussed. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs170151

  9. An Interview with Lance Olsen

    Directory of Open Access Journals (Sweden)

    Ben Segal

    2012-04-01

    Full Text Available With over twenty books to his name, as editor or author, Lance Olsen is a cultural force unto himself. His latest book with Trevor Dodge, Architectures of Possibility (Raw Dog Screaming Press, is a writer's guide against transparent language, and predictable patterned literary convention. In this interview Olsen discusses radical pedagogy and experimental narrative theory and its practice.

  10. The In-Depth Interview as a Research Tool for Investigating the Online Intercultural Communication of Asian Internet Users in Relation to Ethics in Intercultural Research

    Science.gov (United States)

    Fetscher, Doris

    2013-01-01

    Virtual intercultural communication is of great interest in intercultural research. How can a researcher gain access to this field of investigation if s/he does not or only partially speaks the languages used by the subjects? This study is an example of how categories relevant to research can be accessed through in-depth interviews. The interview…

  11. Parent's alcoholism severity and family topic avoidance about alcohol as predictors of perceived stigma among adult children of alcoholics: Implications for emotional and psychological resilience.

    Science.gov (United States)

    Haverfield, Marie C; Theiss, Jennifer A

    2016-01-01

    Alcoholism is a highly stigmatized condition, with both alcohol-dependent individuals and family members of the afflicted experiencing stigmatization. This study examined the severity of a parent's alcoholism and family topic avoidance about alcohol as two factors that are associated with family members' perceptions of stigma. Three dimensions of stigma were considered: discrimination stigma, disclosure stigma, and positive aspect stigma. In addition, this study assessed associations between perceived stigmatization and individuals' experiences of depressive symptoms, self-esteem, and resilience. Adult children of alcoholics (N = 622) were surveyed about family conditions, perceived stigma, and their emotional and psychological well-being. Regression analyses revealed that the severity of a parent's alcoholism predicted all three types of stigma for females, but not for males. In addition, family topic avoidance about alcohol predicted all types of stigma for males and discrimination stigma and positive aspect stigma for females. With few exceptions, the three types of stigma predicted depressive symptoms, self-esteem, and resilience for both male and female adult children of alcoholics. The results are discussed in terms of their implications for promoting a family environment that mitigates stigma and encourages emotional and psychological well-being. In 2012, approximately 3.3 million deaths worldwide were due to the harmful use of alcohol (World Health Organization [WHO], 2014). Individuals who abuse alcohol are susceptible to a variety of negative health outcomes (Rehm et al., 2009) and display inappropriate social behaviors (Klingemann, 2001; Schomerus et al., 2011a). General societal perceptions tend to characterize alcohol-dependent individuals as irresponsible and lacking in self-control (Schomerus et al., 2011b). Research in the United Kingdom found that 54% of the population believes alcohol-dependent individuals are personally to blame for their own

  12. Topical Pain Medications

    Science.gov (United States)

    ... skin Learn about the various types of topical pain medications available for pain relief. Can they ease your ... hurt even though you take your usual arthritis pain medication. Reluctant to pop another pill, you might wonder ...

  13. Topics in Nuclear Astrophysics

    International Nuclear Information System (INIS)

    Chung, K.C.

    1982-01-01

    Some topics in nuclear astrophysics are discussed, e.g.: highly evolved stellar cores, stellar evolution (through the temperature analysis of stellar surface), nucleosynthesis and finally the solar neutrino problem. (L.C.) [pt

  14. Topical approaches to cellulite

    OpenAIRE

    ALĞIN YAPAR, Evren

    2017-01-01

    Today, topical application of pharmacologically active chemicals and local application of physical, mechanical and thermal methods are available in order to eliminate cellulite which is an aesthetic problem that affects the majority of women. Many products on natural or synthetic originated anti-cellulite active ingredients have been developed with topical application studies performed on cellulite developed parts. Formulations developed against cellulite are usually in the form of gel...

  15. Topical application of hemostatic paste

    Directory of Open Access Journals (Sweden)

    Mohammad Mizanur Rahman

    2017-02-01

    Full Text Available As a measure to control minor surgical bleeding, surgeons usually depend on a number of hemostatic aids. Topical use of bovine thrombin is a widely used procedure to arrest such minor bleeding. A 35 year old male sergeant of Bangladesh Air Force presented with repeated development of hematoma in his left thigh without any history of trauma or previous history of bleeding. Critical analysis of the patient’s history, routine and sophisticated hematological investigations revealed that the patient developed anti-thrombin antibody following the application of hemostatic paste in the tooth socket five years back during minor dental procedure to stop ignorable bleeding episodes. Therefore, topical use of hemostatic glue/paste or bovine thrombin should be avoided to desist minor bleeding as recombinant human thrombin is now available for topical use.

  16. Topics in millimeter wave technology

    CERN Document Server

    Button, Kenneth

    1988-01-01

    Topics in Millimeter Wave Technology, Volume 1 presents topics related to millimeter wave technology, including fin-lines and passive components realized in fin-lines, suspended striplines, suspended substrate microstrips, and modal power exchange in multimode fibers. A miniaturized monopulse assembly constructed in planar waveguide with multimode scalar horn feeds is also described. This volume is comprised of five chapters; the first of which deals with the analysis and synthesis techniques for fin-lines as well as the various passive components realized in fin-line. Tapers, discontinuities,

  17. Topics in current aerosol research

    CERN Document Server

    Hidy, G M

    1971-01-01

    Topics in Current Aerosol Research deals with the fundamental aspects of aerosol science, with emphasis on experiment and theory describing highly dispersed aerosols (HDAs) as well as the dynamics of charged suspensions. Topics covered range from the basic properties of HDAs to their formation and methods of generation; sources of electric charges; interactions between fluid and aerosol particles; and one-dimensional motion of charged cloud of particles. This volume is comprised of 13 chapters and begins with an introduction to the basic properties of HDAs, followed by a discussion on the form

  18. Topical treatment of melasma

    Directory of Open Access Journals (Sweden)

    Bandyopadhyay Debabrata

    2009-01-01

    Full Text Available Melasma is a common hypermelanotic disorder affecting the face that is associated with considerable psychological impacts. The management of melasma is challenging and requires a long-term treatment plan. In addition to avoidance of aggravating factors like oral pills and ultraviolet exposure, topical therapy has remained the mainstay of treatment. Multiple options for topical treatment are available, of which hydroquinone (HQ is the most commonly prescribed agent. Besides HQ, other topical agents for which varying degrees of evidence for clinical efficacy exist include azelaic acid, kojic acid, retinoids, topical steroids, glycolic acid, mequinol, and arbutin. Topical medications modify various stages of melanogenesis, the most common mode of action being inhibition of the enzyme, tyrosinase. Combination therapy is the preferred mode of treatment for the synergism and reduction of untoward effects. The most popular combination consists of HQ, a topical steroid, and retinoic acid. Prolonged HQ usage may lead to untoward effects like depigmentation and exogenous ochronosis. The search for safer alternatives has given rise to the development of many newer agents, several of them from natural sources. Well-designed controlled clinical trials are needed to clarify their role in the routine management of melasma.

  19. Identifying Topics in Microblogs Using Wikipedia.

    Directory of Open Access Journals (Sweden)

    Ahmet Yıldırım

    Full Text Available Twitter is an extremely high volume platform for user generated contributions regarding any topic. The wealth of content created at real-time in massive quantities calls for automated approaches to identify the topics of the contributions. Such topics can be utilized in numerous ways, such as public opinion mining, marketing, entertainment, and disaster management. Towards this end, approaches to relate single or partial posts to knowledge base items have been proposed. However, in microblogging systems like Twitter, topics emerge from the culmination of a large number of contributions. Therefore, identifying topics based on collections of posts, where individual posts contribute to some aspect of the greater topic is necessary. Models, such as Latent Dirichlet Allocation (LDA, propose algorithms for relating collections of posts to sets of keywords that represent underlying topics. In these approaches, figuring out what the specific topic(s the keyword sets represent remains as a separate task. Another issue in topic detection is the scope, which is often limited to specific domain, such as health. This work proposes an approach for identifying domain-independent specific topics related to sets of posts. In this approach, individual posts are processed and then aggregated to identify key tokens, which are then mapped to specific topics. Wikipedia article titles are selected to represent topics, since they are up to date, user-generated, sophisticated articles that span topics of human interest. This paper describes the proposed approach, a prototype implementation, and a case study based on data gathered during the heavily contributed periods corresponding to the four US election debates in 2012. The manually evaluated results (0.96 precision and other observations from the study are discussed in detail.

  20. Identifying Topics in Microblogs Using Wikipedia.

    Science.gov (United States)

    Yıldırım, Ahmet; Üsküdarlı, Suzan; Özgür, Arzucan

    2016-01-01

    Twitter is an extremely high volume platform for user generated contributions regarding any topic. The wealth of content created at real-time in massive quantities calls for automated approaches to identify the topics of the contributions. Such topics can be utilized in numerous ways, such as public opinion mining, marketing, entertainment, and disaster management. Towards this end, approaches to relate single or partial posts to knowledge base items have been proposed. However, in microblogging systems like Twitter, topics emerge from the culmination of a large number of contributions. Therefore, identifying topics based on collections of posts, where individual posts contribute to some aspect of the greater topic is necessary. Models, such as Latent Dirichlet Allocation (LDA), propose algorithms for relating collections of posts to sets of keywords that represent underlying topics. In these approaches, figuring out what the specific topic(s) the keyword sets represent remains as a separate task. Another issue in topic detection is the scope, which is often limited to specific domain, such as health. This work proposes an approach for identifying domain-independent specific topics related to sets of posts. In this approach, individual posts are processed and then aggregated to identify key tokens, which are then mapped to specific topics. Wikipedia article titles are selected to represent topics, since they are up to date, user-generated, sophisticated articles that span topics of human interest. This paper describes the proposed approach, a prototype implementation, and a case study based on data gathered during the heavily contributed periods corresponding to the four US election debates in 2012. The manually evaluated results (0.96 precision) and other observations from the study are discussed in detail.

  1. A ciência como profissão: entrevista com Carlos Chagas Filho Science as a profession: an interview with Carlos Chagas Filho

    Directory of Open Access Journals (Sweden)

    Nara Azevedo

    2012-06-01

    Full Text Available A edição desta entrevista privilegia aspectos da extensa trajetória profissional de Carlos Chagas Filho, fundador do Instituto de Biofísica da Universidade do Brasil, atual Universidade Federal do Rio de Janeiro. Evidencia seu papel científico e político na ciência brasileira e no cenário internacional. As memórias de Chagas Filho abrangem a vivência no Instituto Oswaldo Cruz, onde iniciou seu treinamento científico; os esforços para estruturar o Laboratório de Física Biológica, sucedido pelo Instituto de Biofísica; a atuação no Conselho Nacional de Pesquisas e na Academia Brasileira de Ciências; a participação na Organização das Nações Unidas para a Educação, a Ciência e a Cultura; a presidência da Academia Pontifícia do Vaticano, que o leva a tecer considerações sobre a relação entre ciência e religião.The editing of this interview focuses on aspects of the extensive professional career of Carlos Chagas Filho, who was the founder of the Instituto de Biofísica of the Universidade do Brasil, currently the Universidade Federal do Rio de Janeiro. It highlights the scientific and political role he played in Brazilian science and on the international scene. His memoirs include his experience at the Instituto Oswaldo Cruz, where he began his scientific training; the efforts to create the Laboratório de Física Biológica, succeeded by the Instituto de Biofísica; his work on the Conselho Nacional de Pesquisas and the Academia Brasileira de Ciências; the part he played at the United Nations Educational, Scientific and Cultural Organization; his time as president of the Pontifical Academy of Sciences of the Vatican, which led him to ponder questions about the relationship between science and religion.

  2. Hot Topics in Science Teaching

    Science.gov (United States)

    Ediger, Marlow

    2018-01-01

    There are vital topics in science teaching and learning which are mentioned frequently in the literature. Specialists advocate their importance in the curriculum as well as science teachers stress their saliency. Inservice education might well assist new and veteran teachers in knowledge and skills. The very best science lessons and units of…

  3. Superconcentration and related topics

    CERN Document Server

    Chatterjee, Sourav

    2014-01-01

    A certain curious feature of random objects, introduced by the author as “super concentration,” and two related topics, “chaos” and “multiple valleys,” are highlighted in this book. Although super concentration has established itself as a recognized feature in a number of areas of probability theory in the last twenty years (under a variety of names), the author was the first to discover and explore its connections with chaos and multiple valleys. He achieves a substantial degree of simplification and clarity in the presentation of these findings by using the spectral approach. Understanding the fluctuations of random objects is one of the major goals of probability theory and a whole subfield of probability and analysis, called concentration of measure, is devoted to understanding these fluctuations. This subfield offers a range of tools for computing upper bounds on the orders of fluctuations of very complicated random variables. Usually, concentration of measure is useful when more direct prob...

  4. Topics in statistical mechanics

    International Nuclear Information System (INIS)

    Elser, V.

    1984-05-01

    This thesis deals with four independent topics in statistical mechanics: (1) the dimer problem is solved exactly for a hexagonal lattice with general boundary using a known generating function from the theory of partitions. It is shown that the leading term in the entropy depends on the shape of the boundary; (2) continuum models of percolation and self-avoiding walks are introduced with the property that their series expansions are sums over linear graphs with intrinsic combinatorial weights and explicit dimension dependence; (3) a constrained SOS model is used to describe the edge of a simple cubic crystal. Low and high temperature results are derived as well as the detailed behavior near the crystal facet; (4) the microscopic model of the lambda-transition involving atomic permutation cycles is reexamined. In particular, a new derivation of the two-component field theory model of the critical behavior is presented. Results for a lattice model originally proposed by Kikuchi are extended with a high temperature series expansion and Monte Carlo simulation. 30 references

  5. Reflections and Recommendations for Conducting In-Depth Interviews With People With Dementia.

    Science.gov (United States)

    Cridland, Elizabeth K; Phillipson, Lyn; Brennan-Horley, Christopher; Swaffer, Kate

    2016-04-06

    Despite the importance and advantages of including people with dementia in research, there are various challenges for researchers and participants to their involvement. This article draws on the literature and experiences of a diverse group of authors, including a person with dementia, to provide recommendations about conducting research with people with dementia. Particular attention is given to in-depth interviews as a qualitative technique. More specifically, topics discussed include interview guide preparation, recruitment, obtaining consent/assent, conducting effective interviews, analysis and interpretation of data, effective communication of research findings, and reflections and recommendations for maintaining researcher and participant health. Given the current obstacles to participation in research of people with dementia, this is a timely article providing useful insights to promote improved outcomes using in-depth interviews. © The Author(s) 2016.

  6. Interviewer-Respondent Interactions in Conversational and Standardized Interviewing

    Science.gov (United States)

    Mittereder, Felicitas; Durow, Jen; West, Brady T.; Kreuter, Frauke; Conrad, Frederick G.

    2018-01-01

    Standardized interviewing (SI) and conversational interviewing are two approaches to collect survey data that differ in how interviewers address respondent confusion. This article examines interviewer-respondent interactions that occur during these two techniques, focusing on requests for and provisions of clarification. The data derive from an…

  7. Topical therapies in hyperhidrosis care.

    Science.gov (United States)

    Pariser, David M; Ballard, Angela

    2014-10-01

    Primary focal hyperhidrosis affects 3% of the US population; about the same number as psoriasis. More than half of these patients have primary focal axillary hyperhidrosis: sweating that is beyond what is anticipated or necessary for thermoregulation. Most topical therapies are based on aluminum salts, which work by a chemical reaction that forms plugs in the eccrine sweat ducts. Topical anticholinergics may also be used. Instruction on proper methods and timing of antiperspirants enhances effect and may be effective alone or in combination with other treatments in patients with hyperhidrosis. Copyright © 2014 Elsevier Inc. All rights reserved.

  8. TOPICAL REVIEW: Strain compensation technique in self-assembled InAs/GaAs quantum dots for applications to photonic devices

    Science.gov (United States)

    Tatebayashi, J.; Nuntawong, N.; Wong, P. S.; Xin, Y.-C.; Lester, L. F.; Huffaker, D. L.

    2009-04-01

    We report the strain compensation (SC) technique for a stacked InAs/GaAs self-assembled quantum dot (QD) structure grown by metalorganic chemical vapour deposition (MOCVD). Several techniques are used to investigate the effect of the SC technique: the high-resolution x-ray diffraction (XRD) technique is used to quantify the reduction in overall strain, atomic force spectroscopy is used to reveal that the SC layer improves the QD uniformity and reduces the defect density and photoluminescence characterization is used to quantify the optical property of stacked InAs QDs. In addition, experimental and mathematical evaluation of reduction in the strain field in the compensated structure is conducted. We identify two types of strain in stacked QD samples, homogeneous and inhomogeneous strain. XRD spectra indicate that vi > 36% reduction in the homogeneous strain can be accomplished. Inhomogeneous strain field is investigated by studying the strain coupling probability as a function of the spacer thickness, indicating that 19% reduction in inhomogeneous strain within SC structures has been evaluated. Next, device application of SC techniques including lasers and modulators is reported. Room temperature ground-state lasing from 6-stack InAs QDs with GaP SC is realized at a lasing wavelength of 1265 nm with a threshold current density of 108 A cm-2. The electro-optic (EO) properties of 1.3 µm self-assembled InAs/GaAs QDs are investigated. The linear and quadratic EO coefficients are 2.4 × 10-11 m V-1 and 3.2 × 10-18 m2 V-2, respectively, which are significantly larger than those of GaAs bulk materials. Also, the linear EO coefficient is almost comparable to that of lithium niobate.

  9. Motivational interviewing with hazardous drinkers.

    Science.gov (United States)

    Beckham, Nancy

    2007-02-01

    To test the effectiveness of motivational interviewing in a population of hazardous drinkers utilizing community health care centers in rural southeastern Idaho. This study targeted rural people at risk for alcohol dependence utilizing low-income community health care centers in rural southeastern Idaho. The Alcohol Use Disorders Identification Test (AUDIT) was used to screen interested clients' alcohol use. Clients achieving an AUDIT score indicating hazardous alcohol use were recruited into the study and randomized into a control or treatment group. Twenty-six hazardous drinkers attending five low-income community health centers participated in the study. The experimental group participated in one motivational interviewing session with the investigator, a family nurse practitioner (NP). The comparison group received no treatment. Alcohol use was tracked for 6 weeks after successful recruitment into the program. Participants in the study significantly decreased their average number of drinks per day. At time 1 (pretreatment), the control group drank 4.37 drinks per day and the treatment group drank 4.65 drinks per day. At time 2 (posttest), the control group drank 3.77 drinks per day and the treatment group drank 1.95 drinks per day. The effects of the motivational interviewing treatment on hazardous drinking also were measured by serum gamma-glutamyltransferase (GGT), a liver function test. There was also a significant decrease in the GGT from pretest to posttest in the treatment group. The results of this investigation found that motivational interviewing shows promise as an effective intervention for hazardous drinkers attending low-income community clinics. Although other possible explanations could be postulated for the positive changes in sample participants, the data indicate that the motivational interviewing approach was responsible for a significant portion of the positive changes within the current sample. The information collected from the study adds

  10. An Interview with Roy Ellen

    Directory of Open Access Journals (Sweden)

    Nejm Benessaiah

    2014-03-01

    Full Text Available I decided to undertake this interview with Professor Ellen, simply because I thought such a distinguished career deserved to be marked as he was retiring. Roy was happy to make time for our interviews, in the form of loosely structured conversation which, like the Arabian Nights, Roy pointed out, could have gone on forever, but I decided to draw the line at three sessions. Perhaps it could, and will go on to form part of a more in-depth biography, as I continued to discover other aspects and adventures of Roy’s interesting life in the course of other contexts, much as one does in the field. Much is known about what ethnobiologists and anthropologists say about another people’s lives; less is known about their own, apart from rare reflections, diaries and memoires. I found Roy’s reflections a source of comfort as I embarked on my own PhD fieldwork, reassuring me as I fumbled around, making my own unique but comparable mistakes among the insights I gleaned. The following is an edited version of the original interview. I hope it will be as enjoyable to the reader as it was to me working on it.

  11. Recent Advances In Topical Therapy In Dermatology

    Directory of Open Access Journals (Sweden)

    Mohan Thappa Devinder

    2003-01-01

    Full Text Available With changing times various newer topical agents are introduced in the field of dermatology. Tacrolimus and pimecrolimus are immunisuppressants, which are effective topically and are tried in the management of atopic dermatitis as well as other disorders including allergic contact dermatitis, atrophic lichen planus, pyoderma gangrenosum. Imiquimod, an immune response modifier, is presently in use for genital warts but has potentials as anti- tumour agent and in various other dermatological conditions when used topically. Tazarotene is a newer addition to the list of topical reginoids, which is effective in psoriasis and has better effect in combination with calcipotriene, phototherapy and topical costicosteroids. Tazarotene and adapelene are also effective in inflammatory acne. Calcipotriol, a vitamin D analogue has been introduced as a topical agent in the treatment of psoriasis. Steroid components are also developed recently which will be devoid of the side effects but having adequate anti-inflammatory effect. Topical photodynamic therapy has also a wide range of use in dermatology. Newer topical agents including cidofovir, capsaicin, topical sensitizers, topical antifungal agents for onychomycosis are also of use in clinical practice. Other promising developments include skin substitutes and growth factors for wound care.

  12. Selected topics in nuclear structure

    International Nuclear Information System (INIS)

    Stachura, Z.

    1984-09-01

    19. winter school in Zakopane was devoted to selected topics in nuclear structure such as: production of spin resonances, heavy ions reactions and their applications to the investigation of high spin states, octupole deformations, excited states and production of new elements etc. The experimental data are ofen compared with theoretical predictions. Report contains 28 papers. (M.F.W.)

  13. The Effect of Polyhexanide, Octenidine Dihydrochloride, and Tea Tree Oil as Topical Antiseptic Agents on In Vivo Microcirculation of the Human Skin: A Noninvasive Quantitative Analysis.

    Science.gov (United States)

    Rothenberger, Jens; Krauss, Sabrina; Tschumi, Christian; Rahmanian-Schwarz, Afshin; Schaller, Hans-Eberhard; Held, Manuel

    2016-10-01

    Antiseptics are indispensable for wound management and should focus not only on the efficacy in reducing the bacterial burden but also on how much they interfere in wound healing. In this study, the authors analyzed the direct effect of topical antiseptic agents on the microcirculation of intact human skin. The perfusion dynamics were assessed before, and 10 minutes after, the volunteers' fingers of the right hand (n = 20) were immersed in the following solutions - octenidine dihydrochloride, polyhexanide, tea tree oil, and saline solution. The authors used the Oxygen to See (LEA Medizintechnik GmbH, Giessen, Germany) diagnostic device for noninvasive determination of oxygen supply in microcirculation of blood perfused tissues, which combines a laser light to determine blood flow, as well as white light to determine hemoglobin oxygenation and the relative amount of hemoglobin. Tea tree oil (÷19.0%) (B. Braun Melsungen AG, Melsungen, Germany) and polyhexanide (÷12.4%) (Lavanid, Serag Wiessner GmbH, Naila, Germany) caused a significant increase in blood flow compared to the negative control (-25.6%). Octenidine (Octenisept, Schülke & Mayr GmbH, Norderstedt, Germany) showed a nonsignificant trend towards an increase in blood flow (÷7.2%). There were alterations in the values of hemoglobin oxygenation and the relative amount of hemoglobin, but these were not significant. Perfusion is an important factor for wound healing. Therefore, it might be advantageous if antiseptic agents would increase blood flow. Tea tree oil and polyhexanide have a positive effect on skin blood flow and can therefore be used especially in critically perfused wounds, provided the adverse reactions and the antimicrobial efficacy are comparable.

  14. JAVA Interview Questions with Answers

    OpenAIRE

    Mikky, James

    2014-01-01

    JAVA Interview Questions with Answers from ComputerTrainingsOnline.com is n interactive java online training provider to establish a standard present in programming languages training. It is a great opportunity to the people who wants to learn object oriented programming languages like java at their own pace as per the flexible schedules. Here you can share your views and thought procedures with our online community and clarify the queries in java with our core professional team. You can lear...

  15. Endoscopic Resection and Topical 5-Fluorouracil as an Alternative Treatment to Craniofacial Resection for the Management of Primary Intestinal-Type Sinonasal Adenocarcinoma

    Directory of Open Access Journals (Sweden)

    Simon Mackie

    2010-01-01

    Conclusion. Trans-nasal endoscopic resection and topical 5-Fluorouracil could potentially offer an acceptable alternative treatment to the standard of cranio-facial resection. This should be investigated in trials with a longer followup period than this paper in order to directly compare the two treatment modalities.

  16. A retrospective comparison of surgical removal and subsequent CO2 laser ablation versus topical administration of mitomycin C as therapy for equine corneolimbal squamous cell carcinoma.

    Science.gov (United States)

    Clode, Alison B; Miller, Chelsey; McMullen, Richard J; Gilger, Brian C

    2012-07-01

      To compare the complications and nonrecurrence rate following topical mitomycin C (MMC) therapy vs. CO(2) laser ablation for treating equine corneolimbal squamous cell carcinoma (SCC).   Retrospective study.   Twenty-five horses with corneolimbal SCC.   Medical records of horses undergoing surgical tumor resection followed by either topical MMC therapy (0.04%) or CO(2) laser ablation between the years of 2004 and 2010 were reviewed. Recurrence and complications were compared between groups and within MMC subgroups defined by the time at which treatment was initiated relative to surgery.   Therapy with topical MMC resulted in a nonrecurrence rate comparable to that achieved with CO(2) laser ablation (82.4% vs. 85.7%, respectively). Initiation of MMC following epithelialization of the surgical site a mean of 15 days postoperatively did not result in increased recurrence rates relative to treatment in the immediate postoperative period. Vision- or globe-threatening complications tended to occur with greater frequency in horses receiving topical MMC in the immediate postoperative period (5 of 6 major complications) relative to following epithelialization of the surgical site (1 of 6 major complications).   Horses receiving adjunctive topical MMC therapy were no more likely to experience tumor recurrence than were horses undergoing CO(2) laser ablation in the horses in this study. Initiation of two to three rounds of MMC following epithelialization of the surgical site results in fewer major complications and achieves comparable disease resolution relative to treatment in the immediate postoperative period. © 2011 American College of Veterinary Ophthalmologists.

  17. Salicylic Acid Topical

    Science.gov (United States)

    ... the package label for more information.Apply a small amount of the salicylic acid product to one or two small areas you want to treat for 3 days ... know that children and teenagers who have chicken pox or the flu should not use topical salicylic ...

  18. Conditionals Are Topics

    Science.gov (United States)

    Haiman, John

    1978-01-01

    A review of analyses of conditionals (in the philosophical literature) and of topics (primarily in linguistics) reveals that their definitions are very similar. This paper justifies the method of basing semantic analysis of a construction on a cross-linguistic examination of its superficial form. (Author/NCR)

  19. Advanced Topics in Aerodynamics

    DEFF Research Database (Denmark)

    Filippone, Antonino

    1999-01-01

    "Advanced Topics in Aerodynamics" is a comprehensive electronic guide to aerodynamics,computational fluid dynamics, aeronautics, aerospace propulsion systems, design and relatedtechnology. We report data, tables, graphics, sketches,examples, results, photos, technical andscientific literature......, for higher education, learning, reference, research and engineering services....

  20. Characters and Topical Diversity

    DEFF Research Database (Denmark)

    Eriksson, Rune

    2014-01-01

    The purpose of this article is to contribute to our understanding of the difference between the bestseller and the non-bestseller in nonfiction. It is noticed that many bestsellers in nonfiction belongs to the sub-genre of creative nonfiction, but also that the topics in this kind of literature i...

  1. Design and Evaluation of Topical Diclofenac Sodium Gel Using Hot Melt Extrusion Technology as a Continuous Manufacturing Process with Kolliphor® P407.

    Science.gov (United States)

    Pawar, Jaywant; Narkhede, Rajkiran; Amin, Purnima; Tawde, Vaishali

    2017-08-01

    The aim of the present context was to develop and evaluate a Kolliphor® P407-based transdermal gel formulation of diclofenac sodium by hot melt extrusion (HME) technology; central composite design was used to optimize the formulation process. In this study, we have explored first time ever HME as an industrially feasible and continuous manufacturing technology for the manufacturing of gel formulation using Kolliphor® P407 and Kollisolv® PEG400 as a gel base. Diclofenac sodium was used as a model drug. The HME parameters such as feeding rate, screw speed, and barrel temperature were crucial for the semisolid product development, and were optimized after preliminary trials. For the processing of the gel formulation by HME, a modified screw design was used to obtain a uniform product. The obtained product was evaluated for physicochemical characterization such as differential scanning calorimetry (DSC), X-ray diffraction (XRD), pH measurement, rheology, surface tension, and texture profile analysis. Moreover, it was analyzed for general appearance, spreadibility, surface morphology, and drug content. The optimized gel formulation showed homogeneity and transparent film when applied on a glass slide under microscope, pH was 7.02 and uniform drug content of 100.04 ± 2.74 (SD = 3). The DSC and XRD analysis of the HME gel formulation showed complete melting of crystalline API into an amorphous form. The Kolliphor® P407 and Kollisolv® PEG400 formed excellent gel formulation using HME with consistent viscoelastic properties of the product. An improved drug release was found for the HME gel, which showed a 100% drug release than that of a marketed product which showed only 88% of drug release at the end of 12 h. The Flux value of the HME gel was 106 than that of a marketed formulation, which showed only about 60 value, inferring a significant difference (P < 0.05) at the end of 1 h. This study demonstrates a novel application of the hot melt extrusion

  2. [Interview - technique of art (author's transl)].

    Science.gov (United States)

    Estl, M

    1976-01-01

    Interview is defined as "action-like discussion by medium of dialogue with a diagnostic object in view" (SCHRAML), at the same time the importance of the dialogue-purpose and of the motivation of the subject is pointed out. Several methods may be used for conducting the dialogue, their selection being mainly dependent on the vocational training of the investigator. The personality of the investigator plays an important role when interviewing. The interviewer has to take into account the ever present subjectivity to prevent diagnostic mistakes. On the other hand this subjectivity enables the interviewer to get a special diagnostic access when his own ability of empathy and intuition is consciously used. The knowledge of difficult interviewing-techniques is not sufficient, only an integrative coherence awards the single results from the dialogue and simultaneously observation of the subject the adequate position, this makes an interview to an art, whose command is only given to a few.

  3. Tracking topic birth and death in LDA.

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, Andrew T.; Robinson, David Gerald

    2011-09-01

    Most topic modeling algorithms that address the evolution of documents over time use the same number of topics at all times. This obscures the common occurrence in the data where new subjects arise and old ones diminish or disappear entirely. We propose an algorithm to model the birth and death of topics within an LDA-like framework. The user selects an initial number of topics, after which new topics are created and retired without further supervision. Our approach also accommodates many of the acceleration and parallelization schemes developed in recent years for standard LDA. In recent years, topic modeling algorithms such as latent semantic analysis (LSA)[17], latent Dirichlet allocation (LDA)[10] and their descendants have offered a powerful way to explore and interrogate corpora far too large for any human to grasp without assistance. Using such algorithms we are able to search for similar documents, model and track the volume of topics over time, search for correlated topics or model them with a hierarchy. Most of these algorithms are intended for use with static corpora where the number of documents and the size of the vocabulary are known in advance. Moreover, almost all current topic modeling algorithms fix the number of topics as one of the input parameters and keep it fixed across the entire corpus. While this is appropriate for static corpora, it becomes a serious handicap when analyzing time-varying data sets where topics come and go as a matter of course. This is doubly true for online algorithms that may not have the option of revising earlier results in light of new data. To be sure, these algorithms will account for changing data one way or another, but without the ability to adapt to structural changes such as entirely new topics they may do so in counterintuitive ways.

  4. The pharmacology of topical analgesics.

    Science.gov (United States)

    Barkin, Robert L

    2013-07-01

    systemic circulation, topically applied analgesics are associated with application-site reactions in patients, such as dryness, erythema, burning, and discoloration. Furthermore, some adverse events that have been observed in patients may be suggestive of some degree of systemic exposure. This article reviews the mechanisms of action, pharmacokinetics, and tolerability of topical treatments for the management of patient pain.

  5. STS-106 Crew Interviews: Boris Morukov

    Science.gov (United States)

    2000-01-01

    This NASA Johnson Space Center (JSC) video production presents an STS-106 pre-launch interview with Russian Cosmonaut/Mission Specialist Boris Morukov, M.D., Ph.D. Among other topics, Morukov discusses his background in studying weightlessness at the Russian Institute for Biomedical Problems and how his experiences prepared him to become a Cosmonaut candidate. STS-106 is International Space Station assembly flight ISS-2A.2b and will utilize the SPACEHAB Double Module and the Integrated Cargo Carrier (ICC) to take supplies to the station. The mission will also include 2 spacewalks.

  6. STS-106 Crew Interviews: Yuri Malenchenko

    Science.gov (United States)

    2000-01-01

    This NASA Johnson Space Center (JSC) video production presents an STS-106 pre-launch interview with Russian Cosmonaut/Mission Specialist Yuri Malenchenko, Col. Russian Air Force. Among other topics, Malenchenko discusses his 125-day space mission on Russian Space Station MIR in 1994, and his planned spacewalk to complete the connection between the Russian service module Svezda and the International Space Station (ISS). STS-106 is International Space Station assembly flight ISS-2A.2b and will utilize the SPACEHAB Double Module and the Integrated Cargo Carrier (ICC) to take supplies to the station. The mission will also include 2 spacewalks.

  7. Nanosized soy phytosome-based thermogel as topical anti-obesity formulation: an approach for acceptable level of evidence of an effective novel herbal weight loss product

    Directory of Open Access Journals (Sweden)

    El-Menshawe SF

    2018-01-01

    Full Text Available Shahira F El-Menshawe,1 Adel A Ali,1 Mohamed A Rabeh,2 Nermeen M Khalil3 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni Suef, 2Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Giza, 3Department of Pharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, Nahda University Beni-Suef, Beni Suef, Egypt Purpose: Herbal supplements are currently available as a safer alternative to manage obesity, which has become a rising problem over the recent years. Many chemical drugs on the market are designed to prevent or manage obesity but high cost, low efficacy, and multiple side effects limit its use. Nano lipo-vesicles phytosomal thermogel of Soybean, Glycine max (L. Merrill, was formulated and evaluated in an attempt to investigate its anti-obesity action on body weight gain, adipose tissue size, and lipid profile data. Methods: Three different techniques were used to prepare phytosome formulations including solvent evaporation, cosolvency, and salting out. The optimized phytosome formulation was then selected using Design Expert® (version 7.0.0 depending on the highest entrapment efficiency, minimum particle size (PS, and maximum drug release within 2 hours as responses for further evaluation. The successful phytosome complex formation was investigated by means of Fourier-transform infrared spec­troscopy and determination of PS and zeta potential. Phytosome vesicles’ shape was evaluated using transmission electron microscope to ensure its spherical shape. After characterization of the optimized phytosome formulation, it was incorporated into a thermogel formulation. The obtained phytosomal thermogel formulation was evaluated for its clarity, homogeneity, pH, and gel transformation temperature besides rheology behavior and permeation study. An in vivo study was done to investigate the anti-weight-gain effect of soy phytosomal ther­mogel. Results: EE was found to be >99% for all

  8. Evaluation of Carbohydrate-Derived Fulvic Acid (CHD-FA) as a Topical Broad-Spectrum Antimicrobial for Drug-Resistant Wound Infections

    Science.gov (United States)

    2014-10-01

    resistant bacteria and fungi was completed. The minimum inhibitory concentrations (MIC50 and MIC90) for CDH -FA against a collection of over 600...efficacy of topical application of CDH -FA on small animal models of wound infection with a wide variety of bacterial and fungal pathogens. Approach...Establish minimum inhibitory concentrations (MIC50 and MIC90) for CDH -FA against large collections of clinical isolates representing wound-associated

  9. Effects of low-level laser therapy (LLLT) and diclofenac (topical and intramuscular) as single and combined therapy in experimental model of controlled muscle strain in rats.

    Science.gov (United States)

    de Paiva Carvalho, Rodrigo Leal; Leal-Junior, Ernesto Cesar Pinto; Petrellis, Maria Carla; Marcos, Rodrigo Labat; de Carvalho, Maria Helena Catelli; De Nucci, Gilberto; Lopes-Martins, Rodrigo Alvaro Brandão

    2013-01-01

    Muscle injuries represent ca 30% of sports injuries and excessive stretching of muscle causes more than 90% of injuries. Currently the most used treatments are nonsteroidal anti-inflammatory drugs (NSAIDs), however, in last years, low-level laser therapy (LLLT) is becoming an interesting therapeutic modality. The aim of this study was to evaluate the effect of single and combined therapies (LLLT, topical application of diclofenac and intramuscular diclofenac) on functional and biochemical aspects in an experimental model of controlled muscle strain in rats. Muscle strain was induced by overloading tibialis anterior muscle of rats. Injured groups received either no treatment, or a single treatment with topical or intramuscular diclofenac (TD and ID), or LLLT (3 J, 810 nm, 100 mW) 1 h after injury. Walking track analysis was the functional outcome and biochemical analyses included mRNA expression of COX-1 and COX-2 and blood levels of prostaglandin E2 (PGE2 ). All treatments significantly decreased COX-1 and COX-2 gene expression compared with injury group (P < 0.05). However, LLLT showed better effects than TD and ID regarding PGE2 levels and walking track analysis (P < 0.05). We can conclude that LLLT has more efficacy than topical and intramuscular diclofenac in treatment of muscle strain injury in acute stage. © 2012 Wiley Periodicals, Inc. Photochemistry and Photobiology © 2012 The American Society of Photobiology.

  10. Transcultural adaptation of the filial responsibility interview schedule for Brazil.

    Science.gov (United States)

    Aires, M; Weissheimer, A-M; Rosset, I; de Oliveira, F A; de Morais, E P; Paskulin, L M G

    2012-06-01

    In developed countries, filial responsibility in relation to caring for elderly parents has been systematically studied. In Brazil and other developing countries, however, it is a relatively new topic and has not yet been included in the research agenda on ageing. To describe the process of cross-cultural adaptation of the qualitative phase of the filial responsibility interview schedule into Brazilian Portuguese. An expert committee of six team members participated in the study. In addition, individual interviews were held with 11 caregivers of older persons to evaluate the quality of the final Portuguese version of the schedule. The process included examining conceptual, item, semantic and operational equivalencies. Conceptual and item equivalencies were based on a literature review and on discussions with the expert committee. Semantic equivalence was attained through translation, back-translation, expert committee evaluation and pre-testing. The final version was pre-tested in caregivers of older persons enrolled in the home care programme of a primary health care service in Southern Brazil. Conceptual, item, semantic and operational equivalencies were attained. Through the interviews, responses to the open-ended questions concerning filial responsibility in the care for elderly parents pertained to the following categories: possibility of institutionalization of elderly parents, caregiver expectations, difficulties in being a child caregiver and responsibility as a natural process. The Portuguese version presented good semantic equivalence and the results showed that the concepts and items are applicable to the Brazilian context. © 2012 The Authors. International Nursing Review © 2012 International Council of Nurses.

  11. Anesthesia: A Topic for Interdisciplinary Study.

    Science.gov (United States)

    Labianca, Dominick A.; Reeves, William J.

    1977-01-01

    Describes an interdisciplinary approach for teaching the topic of anesthesia as one aspect of a chemistry-oriented course for nonscience majors which focuses on timely topics such as the energy crisis and drugs. Historical treatment with the examination of literature is emphasized in teaching. (HM)

  12. Topics in industrial mathematics

    International Nuclear Information System (INIS)

    Vatsya, S.R.

    1992-01-01

    Mathematical methods are widely used to solve practical problems arising in modern industry. This article outlines some of the topics relevant to AECL programmes. This covers the applications of transmission and neutron transport tomography to determine density distributions in rocks and two phase flow situations. Another example covered is the use of variational methods to solve the problems of aerosol migration and control theory. (author). 7 refs

  13. Comparison of three interview methods on response pattern to sensitive and non-sensitive questions.

    Science.gov (United States)

    Akbar Haghdoost, Ali; Reza Baneshi, Mohammad; Eybpoosh, Sana; Khajehkazemi, Razieh

    2013-06-01

    To get more precise responses when gathering information about sensitive topics such as drug use, it is important to use the most optimal method. This study was carried out to address the impact of three interview methods (street-based, household, and telephone interviews) on response pattern to sensitive and non-sensitive questions in terms of participation, disclosure and discontinuing rates. We selected three culturally diverse major cities of Iran. Then, we randomly selected 300 subjects, 100 for each type of interview, from each major city (899 in total). For street-based interviews only pedestrians who were walking alone were recruited, for household interviews only one individual from each house participated (3-4 houses in each alley were selected), and for telephone interviews we selected phone numbers using a random number list. We asked five non-sensitive and five sensitive (related to drug use and sexual contact among their personal network) questions. For telephone and household interviews, relative to street-based interviews, participants were less likely to disclose alcohol and drug-related behaviors (Adjusted OR = 0.76; 95% CI: 0.60- 0.97) and sexual behaviors among their network (Adjusted OR telephone/street-based = 0.64; 95% CI: 0.39- 1.07 and Adjusted OR household/ street-based = 0.56; 95% CI: 0.33- 0.95). We found that participants who were interviewed via the telephone were more likely (Adjusted OR = 1.24) and those who were interviewed at home were less likely (Adjusted OR = 0.86) to report non-sensitive information compared to participants who were interviewed on the street; however, these findings were not statistically significant. The largest participation rate and the least discontinuation rate were observed for household interviews. It seems that the methods of interview effect response to both sensitive and non-sensitive questions. We believe that for street-based interviews, respondents may disclose more sensitive information than

  14. Motivational Interviewing with computer assistance as an intervention to empower women to make contraceptive choices while incarcerated: study protocol for randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Clarke Jennifer

    2012-07-01

    Full Text Available Abstract Background Unplanned pregnancies and sexually transmitted infections (STIs are important and costly public health problems in the United States resulting from unprotected sexual intercourse. Risk factors for unplanned pregnancies and STIs (poverty, low educational attainment, homelessness, substance abuse, lack of health insurance, history of an abusive environment, and practice of commercial sex work are especially high among women with a history of incarceration. Project CARE (Contraceptive Awareness and Reproductive Education is designed to evaluate an innovative intervention, Motivational Interviewing with Computer Assistance (MICA, aimed at enhancing contraceptive initiation and maintenance among incarcerated women who do not want a pregnancy within the next year and who are anticipated to be released back to the community. This study aims to: (1 increase the initiation of highly effective contraceptives while incarcerated; (2 increase the continuation of highly effective contraceptive use at 3, 6, 9, and 12 months after release; and (3 decrease unsafe sexual activity. Methods/Design This randomized controlled trial will recruit 400 women from the Rhode Island Department of Corrections (RI DOC women’s jail at risk for an unplanned pregnancy (that is, sexually active with men and not planning/wanting to become pregnant in the next year. They will be randomized to two interventions: a control group who receive two educational videos (on contraception, STIs, and pre-conception counseling or a treatment group who receive two sessions of personalized MICA. MICA is based on the principles of the Transtheoretical Model (TTM and on Motivational Interviewing (MI, an empirically supported counseling technique designed to enhance readiness to change targeted behaviors. Women will be followed at 3, 6, 9, and 12 months post release and assessed for STIs, pregnancy, and reported condom use. Discussion Results from this study are expected

  15. Motivational Interviewing and Adolescent Psychopharmacology

    Science.gov (United States)

    Dilallo, John J.; Weiss, Gony

    2009-01-01

    The use of motivational interviewing strategies in the practice of adolescent psychopharmacology is described. Motivational interviewing is an efficient and collaborative style of clinical interaction and this helps adolescent patients to integrate their psychiatric difficulties into a more resilient identity.

  16. Planning for the Job Interview.

    Science.gov (United States)

    Close, Elizabeth, Ed.; Ramsey, Katherine, Ed.

    2000-01-01

    Offers advice from middle school educators (a principal, a supervisor, and a teacher) on job interviews for teaching positions: how applicants are selected from the stack of applications, what happens during an interview, and what truly makes a difference. (SR)

  17. Witness and suspect perceptions of working alliance and interviewing style

    OpenAIRE

    Vanderhallen, Miet; Vervaeke, Geert; Holmberg, Ulf

    2011-01-01

    Abstract: Considerable emphasis is placed on the importance of building rapport when interviewing witnesses and suspects. Despite the abundant literature on the working alliance in therapeutic settings, however, few studies have addressed the topic of rapport in investigative interviewing. Conceptual analysis revealed a number of similarities between the two constructs. This finding suggests the possible benefits of using the theoretical therapeutic construct and operationalisation of the wor...

  18. THE WRITTEN DISCOURSE OF INTERVIEWING STYLE FOR A MAGAZINE INTERVIEW

    Directory of Open Access Journals (Sweden)

    Jessie Barrot

    2012-07-01

    Full Text Available Abstract: This paper examines the written discourse of interviewing style for the purpose of print publication. Specifically, this paper sought to describe and explain the phases of interviewing procedures, the typology of the questions, and the transitional strategies executed by Oprah Winfrey during her interviews for O Magazine. One hundred and ten (110 response-soliciting statements were subjected to discourse analytic procedure to determine the features of such utterances. The results showed that her interview procedure follows a certain pattern that contributes to her ability to maintain the intimacy, familiarity, and dynamics of conversation. Further, results revealed that the interviewer employs a variety of response-soliciting strategies and transitional strategies that unconsciously put the control and authority in the conversation to the interviewees. Finally, some pedagogical implications were also presented for classroom use. Keywords: discourse analysis, interviewing style, interview questions, written discourse

  19. The lifetime prevalence of anxiety disorders in Iceland as estimated by the US National Institute of Mental Health Diagnostic Interview Schedule.

    Science.gov (United States)

    Líndal, E; Stefánsson, J G

    1993-07-01

    The lifetime prevalence of anxiety disorders was estimated in a study of the prevalence of mental disorders in Iceland. The survey instrument was an Icelandic translation of the US National Institute of Mental Health Diagnostic Interview Schedule. The cohort consisted of one half of those born in the year 1931. The participation rate was 79.3%. The overall prevalence of anxiety disorders was 44%, with phobia effecting 18%. The most common anxiety disorder was generalized anxiety, which had a prevalence of 22% and was more common among women. Simple phobia was the most common of the phobic disorders (8.8%), followed by agoraphobia without panic (3.8%), and social phobia (3.5%). The female-male ratio for anxiety disorders was 2:1. Of those with simple phobia, the most common items were a fear of heights (41%); claustrophobia (34%); being on public transportation (31%); the fear of being in crowds and speaking in front of others (28%); of being alone (24%); of insects (22%); of bad weather (21%); and of being in water (aquaphobia) (20%). In addition, 17% of the respondents listed phobias not cited in the DSM-III, and of those with the most common phobic disorder, only 9% had consulted a physician because of this condition. Post-traumatic stress disorder was found to affect women exclusively. Comorbidity shows a mean of at least 3 additional diagnoses.

  20. Household food insecurity as a determinant of overweight and obesity among low-income Hispanic subgroups: Data from the 2011-2012 California Health Interview Survey.

    Science.gov (United States)

    Smith, Teresa M; Colón-Ramos, Uriyoán; Pinard, Courtney A; Yaroch, Amy L

    2016-02-01

    An estimated 78% of Hispanics in the United States (US) are overweight or obese. Household food insecurity, a condition of limited or uncertain access to adequate food, has been associated with obesity rates among Hispanic adults in the US. However, the Hispanic group is multi-ethnic and therefore associations between obesity and food insecurity may not be constant across Hispanic country of origin subgroups. This study sought to determine if the association between obesity and food insecurity among Hispanics is modified by Hispanic ancestry across low-income (≤200% of poverty level) adults living in California. Data are from the cross-sectional 2011-12 California Health Interview Survey (n = 5498). Rates of overweight or obesity (BMI ≥ 25), Calfresh receipt (California's Supplemental Nutrition Assistance Program), and acculturation were examined for differences across subgroups. Weighted multiple logistic regressions examined if household food insecurity was significantly associated with overweight or obesity and modified by country of origin after controlling for age, education, marital status, country of birth (US vs. outside of US), language spoken at home, and Calfresh receipt (P groups, suggesting Hispanic subgroups behave differently in their association between food insecurity and obesity. By highlighting these factors, we can promote targeted obesity prevention interventions, which may contribute to more effective behavior change and reduced chronic disease risk in this population. Copyright © 2015 Elsevier Ltd. All rights reserved.

  1. The Integrated Model of (Dys- Functionality: Reconstructing Patterns of Gaming as Self-Medication in Biographical Interviews with Video Game Addicts

    Directory of Open Access Journals (Sweden)

    Paula Bleckmann

    2015-07-01

    Full Text Available We aim to build a new theory of highly committed problematic video gaming based on rich qualitative data and to compare it to existing theories. To do this, we used hermeneutic analytical methods and grounded theory methodology to analyze 125 hours of recording from 42 biographical interviews, 23 of them with long-term follow-up. Participants were addicted (ex- gamers according to screening instruments, aged 16 to 44, 29 males and 13 females. The integrated (dys- functionality model shows in-game behavior of participants to be dysfunctional in that it hinders advancement in several distinguishable real-life biographical quests (for success, for belonging, and for autonomy and at the same time functional in that it matches these quests. The model integrates two seemingly irreconcilable research traditions: The addiction/disease model in medical-psychological research investigates dysfunctionality of gaming in pathological gamers. Game studies focus on functionality of in-game behavior and establish gamer typologies based on gaming motives. By adding the biographical context to game studies, but keeping the gamer's perspective, we show that gamers whose lives become dominated by gaming may know what they want and "virtually" get it, but still not "really" get it in the long term. "Compensatory" gaming does not, thus, equal unproblematic or "non-addicted" gaming. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs150387

  2. Topics in Bethe Ansatz

    Science.gov (United States)

    Wang, Chunguang

    Integrable quantum spin chains have close connections to integrable quantum field. theories, modern condensed matter physics, string and Yang-Mills theories. Bethe. ansatz is one of the most important approaches for solving quantum integrable spin. chains. At the heart of the algebraic structure of integrable quantum spin chains is. the quantum Yang-Baxter equation and the boundary Yang-Baxter equation. This. thesis focuses on four topics in Bethe ansatz. The Bethe equations for the isotropic periodic spin-1/2 Heisenberg chain with N. sites have solutions containing ±i/2 that are singular: both the corresponding energy and the algebraic Bethe ansatz vector are divergent. Such solutions must be carefully regularized. We consider a regularization involving a parameter that can be. determined using a generalization of the Bethe equations. These generalized Bethe. equations provide a practical way of determining which singular solutions correspond. to eigenvectors of the model. The Bethe equations for the periodic XXX and XXZ spin chains admit singular. solutions, for which the corresponding eigenvalues and eigenvectors are ill-defined. We use a twist regularization to derive conditions for such singular solutions to bephysical, in which case they correspond to genuine eigenvalues and eigenvectors of. the Hamiltonian. We analyze the ground state of the open spin-1/2 isotropic quantum spin chain. with a non-diagonal boundary term using a recently proposed Bethe ansatz solution. As the coefficient of the non-diagonal boundary term tends to zero, the Bethe roots. split evenly into two sets: those that remain finite, and those that become infinite. We. argue that the former satisfy conventional Bethe equations, while the latter satisfy a. generalization of the Richardson-Gaudin equations. We derive an expression for the. leading correction to the boundary energy in terms of the boundary parameters. We argue that the Hamiltonians for A(2) 2n open quantum spin chains

  3. Pre-Service Physics Teachers' Opinions about the Difficulties in Understanding Introductory Quantum Physics Topics

    Science.gov (United States)

    Kizilcik, Hasan Sahin; Yavas, Pervin Ünlü

    2017-01-01

    The aim of this study is to identify the opinions of pre-service physics teachers about the difficulties in introductory quantum physics topics. In this study conducted with twenty-five pre-service physics teachers, the case study method was used. The participants were interviewed about introductory quantum physics topics. The interviews were…

  4. Interviewing When You’re Not Face-To-Face: The Use of Email Interviews in a Phenomenological Study

    Directory of Open Access Journals (Sweden)

    Chandra Bowden

    2015-01-01

    Full Text Available As Internet usage becomes more commonplace, researchers are beginning to explore the use of email interviews. Email interviews have a unique set of tools, advantages, and limitations, and are not meant to be blind reproductions of traditional face-to-face interview techniques. Email interviews should be implemented when: 1 researchers can justify email interviews are useful to a research project; 2 there is evidence that the target population will be open to email interviewing as a form of data collection; and 3 the justification of the email interview supports the researchers’ theoretical perspective. The objective of this study was to develop an email interviewing methodology. As with other forms of qualitative interviewing, it is important that the researcher: 1 identifies constraints; 2 adequately prepares for the interview; 3 establishes rapport; 4 asks appropriate questions; 5 actively listens; and 6 ends the email interview appropriately.

  5. Split-Session Focus Group Interviews in the Naturalistic Setting of Family Medicine Offices.

    Science.gov (United States)

    Fetters, Michael D; Guetterman, Timothy C; Power, Debra; Nease, Donald E

    2016-01-01

    When recruiting health care professionals to focus group interviews, investigators encounter challenges such as busy clinic schedules, recruitment, and a desire to get candid responses from diverse participants. We sought to overcome these challenges using an innovative, office-based, split-session focus group procedure in a project that elicited feedback from family medicine practices regarding a new preventive services model. This procedure entails allocating a portion of time to the entire group and the remaining time to individual subgroups. We discuss the methodologic procedure and the implications of using this approach for data collection. We conducted split-session focus groups with physicians and staff in 4 primary care practices. The procedure entailed 3 sessions, each lasting 30 minutes: the moderator interviewed physicians and staff together, physicians alone, and staff alone. As part of the focus group interview, we elicited and analyzed participant comments about the split-session format and collected observational field notes. The split-session focus group interviews leveraged the naturalistic setting of the office for context-relevant discussion. We tested alternate formats that began in the morning and at lunchtime, to parallel each practice's workflow. The split-session approach facilitated discussion of topics primarily relevant to staff among staff, topics primarily relevant to physicians among physicians, and topics common to all among all. Qualitative feedback on this approach was uniformly positive. A split-session focus group interview provides an efficient, effective way to elicit candid qualitative information from all members of a primary care practice in the naturalistic setting where they work. © 2016 Annals of Family Medicine, Inc.

  6. Topic Visualization and Survival Analysis

    OpenAIRE

    Wang, Ping Jr

    2017-01-01

    Latent semantic structure in a text collection is called a topic. In this thesis, we aim to visualize topics in the scientific literature and detect active or inactive research areas based on their lifetime. Topics were extracted from over 1 million abstracts from the arXiv.org database using Latent Dirichlet Allocation (LDA). Hellinger distance measures similarity between two topics. Topics are determined to be relevant if their pairwise distances are smaller than the threshold of Hellinger ...

  7. Resumes and Interviews: A Guide for Cosmetology. Student's Manual [and] Instructor's Guide.

    Science.gov (United States)

    Selke, Barbara E.

    The student's manual of this set consists of materials dealing with resume writing and job interview skills needed by individuals enrolled in cosmetology instructor training programs. Addressed in the individual units of the course are the following topics: resumes and employment applications, employment interviews, and preenrollment interviews.…

  8. Long-term follow-up of conjunctival melanoma treated with topical interferon alpha-2b eye drops as adjunctive therapy following surgical resection.

    Science.gov (United States)

    Kikuchi, Iku; Kase, Satoru; Ishijima, Kan; Ishida, Susumu

    2017-11-01

    The purpose of this study was to report the clinical outcomes of patients with conjunctival melanoma treated with interferon (IFN) α-2b eye drops following local tumor resection. Five eyes of five patients were enrolled in this study. All patients underwent the local resection of tumors, and topical IFNα-2b eye drops were subsequently administered 4 times/day until the complete disappearance of the pigmented lesions determined by slit-lamp examination. Ophthalmological findings, histopathological findings, and imaging modalities were retrospectively analyzed. The age of the patients ranged from 65 to 84 years (mean: 75.4 years). Locations of the tumor were the bulbar conjunctiva in three eyes, multiple palpebral conjunctivas in one eye, and palpebral conjunctiva and caruncle in one eye. All patients received topical IFNα-2b eye drop treatment for 6-10 months. Follow-up periods after resection ranged from 18 to 78 months. Histologically, all excised conjunctival tumors were diagnosed with malignant melanoma, where the surgical margins were completely negative in one patient. No patients had suffered from severe adverse effects related to IFNα-2b. Four out of five patients consequently achieved complete remission. Since one eye in one case showed resistance to the local chemotherapy containing IFNα-2b eye drops and the subconjunctival injection of IFN-β, orbital exenteration was eventually required 12 months after local resection. Topical IFNα-2b eye drops may be safe and one of the useful adjunctive treatments following surgical resection for patients with conjunctival melanoma.

  9. Topical treatment options for allergic conjunctivitis

    African Journals Online (AJOL)

    of topical dual-acting agents which have mast cell stabilising properties and act as antihistamines. Although corticosteroids are among the most effective agents in the treatment of .... diclofenac, has been shown to reduce ocular inflammation in VKC, and to reduce topical steroid use in these patients.9. Although ketorolac ...

  10. Being a quantitative interviewer: qualitatively exploring interviewers' experiences in a longitudinal cohort study

    Directory of Open Access Journals (Sweden)

    Derrett Sarah

    2011-12-01

    place in the event of sensitive situations - this appeared to alleviate the pressure on interviewers to carry the burden of responsibility. Interviewers are employed to scientifically gather quantitative data, yet their effectiveness relies largely on their humanity. We propose that the personal connection generated between the interviewers and participants was important, and enabled successful follow-up rates for the study. The enjoyment of these relationships was crucial to interviewers and helped balance the negative aspects of their role. Our results suggest that experienced quantitative interviewers endeavour, as do many qualitative researchers, to carefully and respectfully negotiate the requirements of the interview within a relationship they form with participants: being sensitive to the needs of participants and respectful of their wishes - and establishing an ethical relationship.

  11. Hot topics in functional neuroradiology.

    Science.gov (United States)

    Faro, S H; Mohamed, F B; Helpern, J A; Jensen, J H; Thulborn, K R; Atkinson, I C; Sair, H I; Mikulis, D J

    2013-12-01

    Functional neuroradiology represents a relatively new and ever-growing subspecialty in the field of neuroradiology. Neuroradiology has evolved beyond anatomy and basic tissue signal characteristics and strives to understand the underlying physiologic processes of central nervous system disease. The American Society of Functional Neuroradiology sponsors a yearly educational and scientific meeting, and the educational committee was asked to suggest a few cutting-edge functional neuroradiology techniques (hot topics). The following is a review of several of these topics and includes "Diffusion Tensor Imaging of the Pediatric Spinal Cord"; "Diffusional Kurtosis Imaging"; "From Standardization to Quantification: Beyond Biomarkers toward Bioscales as Neuro MR Imaging Surrogates of Clinical End Points"; Resting-State Functional MR Imaging"; and "Current Use of Cerebrovascular Reserve Imaging."

  12. Medical Student Mock Interviews to Improve Residency Interviewing and Match Success.

    Science.gov (United States)

    Hueston, William J; Holloway, Richard L

    2016-04-01

    Using a quasi-experimental approach, we examined student and faculty satisfaction with a mock residency interview program. We also examined whether self-selected participants had match rates that differed from nonparticipants. Interviews were arranged on a specified evening between students and a physician in the specialty to which the student wished to apply. Interviews were structured as similarly to residency interviews as possible, but included 10 minutes of verbal feedback and subsequent written feedback to all students. Students completed surveys indicating their satisfaction with the mock interview immediately following the interview and 5 months later (after their actual resident interviews). Faculty feedback to students and their satisfaction with the program also was collected. Out of 189 (55%) students in the senior class, 104 volunteered to participate. Immediately following the mock interview, over 90% of students who participated either strongly agreed or agreed that the interview feedback was helpful, seemed realistic, and helped them identify strengths and weaknesses. Responses collected 5 months later were still favorable, but less positive. Faculty identified 7 students who they believed had poor interview techniques and an additional 13 who interviewers believed would be unlikely to match in their specialty. Final match results for the group participating in the mock interview showed a primary match rate of 99%, which was higher than students who did not participate (94%, P interviews were useful in improving student match success compared to students who did not participate in the mock interview program. Because all students were not required to participate, it is unclear whether this tactic would be successful for all students.

  13. Topics in Nonlinear Dynamics

    DEFF Research Database (Denmark)

    Mosekilde, Erik

    Through a significant number of detailed and realistic examples this book illustrates how the insights gained over the past couple of decades in the fields of nonlinear dynamics and chaos theory can be applied in practice. Aomng the topics considered are microbiological reaction systems, ecological...... food-web systems, nephron pressure and flow regulation, pulsatile secretion of hormones, thermostatically controlled radiator systems, post-stall maneuvering of aircrafts, transfer electron devices for microwave generation, economic long waves, human decision making behavior, and pattern formation...... in chemical reaction-diffusion systems....

  14. Topics in CP violation

    Energy Technology Data Exchange (ETDEWEB)

    Quinn, H.R.

    1993-02-01

    Given the varied backgrounds of the members of this audience this talk will be a grab bag of topics related to the general theme of CP Violation. I do not have time to dwell in detail on any of them. First, for the astronomers and astrophysicists among you, I want to begin by reviewing the experimental status of evidence for CP violation in particle processes. There is only one system where this has been observed, and that is in the decays of neutral K mesons.

  15. Topical diclofenac does not affect the antiplatelet properties of aspirin as compared to the intermediate effects of oral diclofenac: A prospective, randomized, complete crossover study.

    Science.gov (United States)

    Rowcliffe, M; Nezami, B; Westphal, E S; Rainka, M; Janda, M; Bates, V; Gengo, F

    2016-04-01

    Nonsteroidal anti-inflammatory drugs (NSAIDs) adversely interact with aspirin, diminishing its antiplatelet effect and potentially placing patients at an increased risk for recurrent thrombotic events. This crossover study aimed to determine whether the topical NSAID diclofenac epolamine 1.3% patch or oral diclofenac 50 mg interfered with the antiplatelet effects of aspirin 325 mg. Twelve healthy men and women aged 18-50 were included. Participants were randomized into 5 treatment arms: aspirin, diclofenac potassium 50 mg, diclofenac patch, diclofenac potassium plus ASA 325 mg, and diclofenac patch plus aspirin. Platelet responsiveness was determined using whole-blood impedance aggregation (WBA) to collagen 1 μg/mL and arachidonic acid (AA) 0.5 mM and was sampled every 2 hours. No significant difference in platelet function was observed following the diclofenac patch and aspirin vs aspirin alone. Oral diclofenac produced a mixed effect with significant reduction in platelet inhibition at hour 2 and hour 8 following aspirin administration. Topical diclofenac does not significantly interfere with the antiplatelet effects of aspirin and may be a safer alternative to the oral formulation. © 2015, The American College of Clinical Pharmacology.

  16. Computer assisted self interviewing in a sexual health clinic as part of routine clinical care; impact on service and patient and clinician views.

    Directory of Open Access Journals (Sweden)

    Lenka A Vodstrcil

    Full Text Available BACKGROUND: Computer assisted self interviewing (CASI has been used at the Melbourne Sexual Health Centre (MSHC since 2008 for obtaining sexual history and identifying patients' risk factors for sexually transmitted infections (STIs. We aimed to evaluate the impact of CASI operating at MSHC. METHODOLOGY/PRINCIPAL FINDINGS: The proportion of patients who decline to answer questions using CASI was determined. We then compared consultation times and STI-testing rates during comparable CASI and non-CASI operating periods. Patients and staff completed anonymous questionnaires about their experience with CASI. 14,190 patients completed CASI during the audit period. Men were more likely than women to decline questions about the number of partners they had of the opposite sex (4.4% v 3.6%, p=0.05 and same sex (8.9% v 0%, p<0.001. One third (34% of HIV-positive men declined the number of partners they had and 11-17% declined questions about condom use. Women were more likely than men to decline to answer questions about condom use (2.9% v 2.3%, p=0.05. There was no difference in the mean consultation times during CASI and non-CASI operating periods (p≥0.17. Only the proportion of women tested for chlamydia differed between the CASI and non-CASI period (84% v 88% respectively, p<0.01. 267 patients completed the survey about CASI. Most (72% men and 69% women were comfortable using the computer and reported that all their answers were accurate (76% men and 71% women. Half preferred CASI but 18% would have preferred a clinician to have asked the questions. 39 clinicians completed the staff survey. Clinicians felt that for some STI risk factors (range 11%-44%, face-to-face questioning was more accurate than CASI. Only 5% were unsatisfied with CASI. CONCLUSIONS: We have demonstrated that CASI is acceptable to both patients and clinicians in a sexual health setting and does not adversely affect various measures of clinical output.

  17. Atopic dermatitis: skin care and topical therapies.

    Science.gov (United States)

    Fleischer, David M; Udkoff, Jeremy; Borok, Jenna; Friedman, Adam; Nicol, Noreen; Bienstock, Jeffrey; Lio, Peter; Tollefson, Megha M; Eichenfield, Lawrence F

    2017-09-01

    Atopic dermatitis (AD) pathogenesis is strongly influenced by Type 2 innate lymphoid cell and T-helper cell type 2 lymphocyte-driven inflammation and skin barrier dysfunction. AD therapies attempt to correct this pathology, and guidelines suggest suggest basics of AD therapy, which include repair of the skin barrier through bathing practices and moisturizers, infection control, and further lifestyle modifications to avoid and reduce AD triggers.While some patients' AD may be controlled using these measures, inflammatory eczema including acute flares and maintenance therapy in more severe patients are treated with topical pharmacologic agents such as topical corticosteroids, topical calcineurin inhibitors, and, more recently, topical PDE-4 inhibitors. This model of basic skin therapy and, as needed, topical pharmacologic agents may be used to treat the vast majority of patients with AD and remains the staple of AD therapy. ©2017 Frontline Medical Communications.

  18. [Topical anesthesia in flexible nasofibrolaryngoscopy].

    Science.gov (United States)

    Chiesa Estomba, Carlos Miguel; Ossa Echeverri, Carla Cristina; Araujo da Costa, Ana Sofía; Rivera Schmitz, Teresa; Castro Ruiz, Pilar; Santidrián Hidalgo, Carmelo

    2015-01-01

    The emergence of flexible nasofibrolaryngoscopy in recent decades has facilitated the development of Otolaryngology and the nasofibrolaryngoscope has become an essential diagnostic tool for the otolaryngologist. However, its use is not without discomfort for the patient, which is why various options for topical anaesthesia have been proposed during the development of the technique. This was a prospective, double blind, crossover study in patients with no history of nasal disease, through which we compared the use of topical anaesthetic (Lidocaine) + epinephrine, oxymetazoline and placebo. Using a visual analogue scale, the degree of discomfort was assessed during each scan. We evaluated 18 patients, 10 women (55.6%) and 8 men (44.4%), with a mean age of 28±4 years. The degree of disturbance generated by the scan with the application of lidocaine-epinephrine was 1.94; with oxymetazoline it was 3.78, and with placebo, 4.61. When the lidocaine-epinephrine solution was compared with oxymetazoline, there was a statistical significance in favour of lidocaine-epinephrine (P<0.05). When we compared the use of lidocaine-epinephrine with the placebo, the result was also statistically significant in favour of lidocaine-epinephrine (P<0.05). In this study we demonstrated that using lidocaine associated with epinephrine as a topical anaesthetic prior to flexible nasofibrolaryngoscopy decreases pain and feeling of discomfort for the patient. Consequently, we can recommend the use of topical nasal anaesthesia when performing this exploration. Copyright © 2014 Elsevier España, S.L.U. y Sociedad Española de Otorrinolaringología y Patología Cérvico-Facial. All rights reserved.

  19. Interactional Alarms: Experts' Framing of Health Risks in Live Broadcast News Interviews.

    Science.gov (United States)

    Armon, Rony

    2017-08-23

    This study examined how experts frame health risks in real-time interactions with journalists. Though there is evidence that experts influence media framing of health risks, the ways they respond to journalists' agendas in real-time interactions have yet to be explored. This paper examines instances of risk assessment extracted from a corpus of news interviews to determine how expert assessments were requested and provided. The analysis reveals that experts rarely deliver their assessments neutrally but rather treat these exchanges as opportunities for framing or reframing the topic. Their framing is shown to be responsive to journalistic agendas and to those who experts understand to be accountable when their assessment is elicited. These findings suggest ways in which news interviews can be useful in health communication. The implications for experts, journalists, and public information officers who plan to use interviews for this purpose are discussed.

  20. Revisiting the hypothesis-driven interview in a contemporary context.

    Science.gov (United States)

    Holmes, Alex; Singh, Bruce; McColl, Geoff

    2011-12-01

    The "hypothesis-driven interview" was articulated by George Engel as a method of raising and testing hypotheses in the process of building a biopsychosocial formulation and determining the most likely diagnosis. This interview was a forerunner of the modern medical interview as well as the contemporary psychiatric assessment. The objective of this article is to describe the hypothesis-driven interview and to explore its relationship with the contemporary medical interview. The literature on the medical and hypothesis-driven interview was reviewed. Key features of each were identified. The hypothesis-driven interview shares much with the contemporary medical interview. In addition, it enhances the application of communication skills and allows the interviewer to develop a formulation during the course of the assessment. The hypothesis-driven interview is well suited to the aims of a contemporary psychiatric assessment.

  1. STS-112 Crew Interviews - Magnus

    Science.gov (United States)

    2002-01-01

    STS-112 Mission Specialist 2 Sandra H. Magnus is seen during a prelaunch interview. She answers questions about her inspiration to become an astronaut and her career path. She gives details on the mission's goals, the most significant of which will be the installation of the S-1 truss structure on the International Space Station (ISS). The installation, one in a series of truss extending missions, will be complicated and will require the use of the robotic arm as well as extravehicular activity (EVA) by astronauts. Magnus also describes her function in the performance of transfer operations. Brief descriptions are given of experiments on board the ISS as well as on board the Shuttle.

  2. Cognitive interviewing methods for questionnaire pre-testing in homeless persons with mental disorders.

    Science.gov (United States)

    Adair, Carol E; Holland, Anna C; Patterson, Michelle L; Mason, Kate S; Goering, Paula N; Hwang, Stephen W

    2012-02-01

    In this study, cognitive interviewing methods were used to test targeted questionnaire items from a battery of quantitative instruments selected for a large multisite trial of supported housing interventions for homeless individuals with mental disorders. Most of the instruments had no published psychometrics in this population. Participants were 30 homeless adults with mental disorders (including substance use disorders) recruited from service agencies in Vancouver, Winnipeg, and Toronto, Canada. Six interviewers, trained in cognitive interviewing methods and using standard interview schedules, conducted the interviews. Questions and, in some cases, instructions, for testing were selected from existing instruments according to a priori criteria. Items on physical and mental health status, housing quality and living situation, substance use, health and justice system service use, and community integration were tested. The focus of testing was on relevance, comprehension, and recall, and on sensitivity/acceptability for this population. Findings were collated across items by site and conclusions validated by interviewers. There was both variation and similarity of responses for identified topics of interest. With respect to relevance, many items on the questionnaires were not applicable to homeless people. Comprehension varied considerably; thus, both checks on understanding and methods to assist comprehension and recall are recommended, particularly for participants with acute symptoms of mental illness and those with cognitive impairment. The acceptability of items ranged widely across the sample, but findings were consistent with previous literature, which indicates that "how you ask" is as important as "what you ask." Cognitive interviewing methods worked well and elicited information crucial to effective measurement in this unique population. Pretesting study instruments, including standard instruments, for use in special populations such as homeless

  3. Student Expenses in Residency Interviewing.

    Science.gov (United States)

    Walling, Anne; Nilsen, Kari; Callaway, Paul; Grothusen, Jill; Gillenwater, Cole; King, Samantha; Unruh, Gregory

    2017-08-01

    The student costs of residency interviewing are of increasing concern but limited current information is available. Updated, more detailed information would assist students and residency programs in decisions about residency selection. The study objective was to measure the expenses and time spent in residency interviewing by the 2016 graduating class of the University of Kansas School of Medicine and assess the impact of gender, regional campus location, and primary care application. All 195 students who participated in the 2016 National Residency Matching Program (NRMP) received a 33 item questionnaire addressing interviewing activity, expenses incurred, time invested and related factors. Main measures were self-reported estimates of expenses and time spent interviewing. Descriptive analyses were applied to participant characteristics and responses. Multivariate analysis of variance (MANOVA) and chi-square tests compared students by gender, campus (main/regional), and primary care/other specialties. Analyses of variance (ANOVA) on the dependent variables provided follow-up tests on significant MANOVA results. A total of 163 students (84%) completed the survey. The average student reported 38 (1-124) applications, 16 (1-54) invitations, 11 (1-28) completed interviews, and spent $3,500 ($20-$12,000) and 26 (1-90) days interviewing. No significant differences were found by gender. After MANOVA and ANOVA analyses, non-primary care applicants reported significantly more applications, interviews, and expenditures, but less program financial support. Regional campus students reported significantly fewer invitations, interviews, and days interviewing, but equivalent costs when controlled for primary care application. Cost was a limiting factor in accepting interviews for 63% and time for 53% of study respondents. Students reported investing significant time and money in interviewing. After controlling for other variables, primary care was associated with significantly

  4. Insights from an Editor's Journey: An Interview with Gert Biesta

    Science.gov (United States)

    Teschers, Christoph

    2017-01-01

    Gert J. J. Biesta is a widely known and respected scholar in the field of education. He has published a large number of articles, books, chapters and other work. He is currently professor of Education in the Department of Education at Brunel University London. This interview with Biesta touched on a wide range of topics. This article is a…

  5. Hilary Putnam Interviewed by Naoko Saito and Paul Standish

    Science.gov (United States)

    Journal of Philosophy of Education, 2014

    2014-01-01

    The interview, which took place on the eve of the 2012 American presidential election, coincides with the publication of three major works by or about Hilary Putnam. It begins and ends with the topic of science, drawing attention to science's profound importance but also to its contemporary forms of distortion. It explores Putnam's…

  6. Talking about Happiness: Interview Research and Well-Being

    Science.gov (United States)

    Campbell, Jennifer

    2016-01-01

    In addition to teaching research and writing skills, First-Year Composition classes are well situated to help students develop strategies for managing stress and increasing well-being. I describe an assignment sequence in which students interview others from three generations about topics related to happiness and wellbeing, analyze shared…

  7. Topic and Topic-Comment Constructions in Mandarin Chinese.

    Science.gov (United States)

    Shi, Dingxu

    2000-01-01

    Attempts to provide a precise definition for topic and to derive most of the properties of topic from this definition. The main assumption is that the topic-comment construction is a syntactic device employed to fulfill certain discourse functions. (Author/VWL)

  8. Tactile friction of topical formulations.

    Science.gov (United States)

    Skedung, L; Buraczewska-Norin, I; Dawood, N; Rutland, M W; Ringstad, L

    2016-02-01

    The tactile perception is essential for all types of topical formulations (cosmetic, pharmaceutical, medical device) and the possibility to predict the sensorial response by using instrumental methods instead of sensory testing would save time and cost at an early stage product development. Here, we report on an instrumental evaluation method using tactile friction measurements to estimate perceptual attributes of topical formulations. Friction was measured between an index finger and an artificial skin substrate after application of formulations using a force sensor. Both model formulations of liquid crystalline phase structures with significantly different tactile properties, as well as commercial pharmaceutical moisturizing creams being more tactile-similar, were investigated. Friction coefficients were calculated as the ratio of the friction force to the applied load. The structures of the model formulations and phase transitions as a result of water evaporation were identified using optical microscopy. The friction device could distinguish friction coefficients between the phase structures, as well as the commercial creams after spreading and absorption into the substrate. In addition, phase transitions resulting in alterations in the feel of the formulations could be detected. A correlation was established between skin hydration and friction coefficient, where hydrated skin gave rise to higher friction. Also a link between skin smoothening and finger friction was established for the commercial moisturizing creams, although further investigations are needed to analyse this and correlations with other sensorial attributes in more detail. The present investigation shows that tactile friction measurements have potential as an alternative or complement in the evaluation of perception of topical formulations. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  9. Using Multiple Interviewers in Qualitative Research Studies: The Influence of Ethic of Care Behaviors in Research Interview Settings

    Science.gov (United States)

    Matteson, Shirley M.; Lincoln, Yvonna S.

    2009-01-01

    This study considered the methodological implications of a qualitative study that involved two research practitioners as interviewers, one male and one female, who conducted semistructured cognitive interviews with middle school students. During the reading and analysis of interview transcriptions, differences were noted between the interviewers'…

  10. An Interview with Adolf Muschg

    Directory of Open Access Journals (Sweden)

    Judith Ricker-Abderhalden

    1984-01-01

    Full Text Available Adolf Muschg, a popular writer, teacher and aesthetician, is one of the comparatively few contemporary Swiss writers who has been able to establish himself firmly in Germany. In recent years, he has begun to attract the attention of American critics and Germanists as well. In the interview, Adolf Muschg deals with a wide spectrum of issues. He identifies the authors and works that mean most to him. He traces, for instance, his changing relationship to Goethe, whom he recently rediscovered. In Goethe's works, above all in his scientific studies, Muschg finds issues that are of central importance to the survival of our planet. He detects a kinship between Goethe and the "Greens" of the seventies and looks back critically on the turbulent sixties. He provides an analysis of the current tensions between the USA and Western Europe, while confirming his keen and very personal involvement with the USA. But at the core of the interview are his extensive comments on the creative processes and the perils inherent in writing fiction. There he deals with the complex relationship between literature and therapy, the therapeutic potential of literature for the writer and the reader. By describing the novelist's difficult journey on the narrow path between self-revelation and indiscretion, he also reflects upon the related issue of literary narcissism.

  11. Torpedo: topic periodicity discovery from text data

    Science.gov (United States)

    Wang, Jingjing; Deng, Hongbo; Han, Jiawei

    2015-05-01

    Although history may not repeat itself, many human activities are inherently periodic, recurring daily, weekly, monthly, yearly or following some other periods. Such recurring activities may not repeat the same set of keywords, but they do share similar topics. Thus it is interesting to mine topic periodicity from text data instead of just looking at the temporal behavior of a single keyword/phrase. Some previous preliminary studies in this direction prespecify a periodic temporal template for each topic. In this paper, we remove this restriction and propose a simple yet effective framework Torpedo to mine periodic/recurrent patterns from text, such as news articles, search query logs, research papers, and web blogs. We first transform text data into topic-specific time series by a time dependent topic modeling module, where each of the time series characterizes the temporal behavior of a topic. Then we use time series techniques to detect periodicity. Hence we both obtain a clear view of how topics distribute over time and enable the automatic discovery of periods that are inherent in each topic. Theoretical and experimental analyses demonstrate the advantage of Torpedo over existing work.

  12. Interview with Eddie Reisch

    Science.gov (United States)

    Owen, Hazel

    2013-01-01

    Eddie Reisch is currently working as a policy advisor for Te Reo Maori Operational Policy within the Student Achievement group with the Ministry of Education in New Zealand, where he has implemented and led a range of e-learning initiatives and developments, particularly the Virtual Learning Network (VLN). He is regarded as one of the leading…

  13. Interview with David Moore

    Science.gov (United States)

    Rossman, Allan; Dietz, E. Jacquelin; Moor, David

    2013-01-01

    David Moore is Professor Emeritus of Statistics at Purdue University. He served as the first President of the International Association for Statistical Education (IASE) from 1993-1995 and as President of the American Statistical Association (ASA) in 1998. He is a Fellow of the ASA and of the IMS and was awarded the ASA's Founders Award in…

  14. Topical Acne Treatments and Pregnancy

    Science.gov (United States)

    Topical Acne Treatments and Pregnancy In every pregnancy, a woman starts out with a 3-5% chance of having ... This sheet talks about whether exposure to topical acne treatments may increase the risk for birth defects ...

  15. Topics in orbit equivalence

    CERN Document Server

    Kechris, Alexander S

    2004-01-01

    This volume provides a self-contained introduction to some topics in orbit equivalence theory, a branch of ergodic theory. The first two chapters focus on hyperfiniteness and amenability. Included here are proofs of Dye's theorem that probability measure-preserving, ergodic actions of the integers are orbit equivalent and of the theorem of Connes-Feldman-Weiss identifying amenability and hyperfiniteness for non-singular equivalence relations. The presentation here is often influenced by descriptive set theory, and Borel and generic analogs of various results are discussed. The final chapter is a detailed account of Gaboriau's recent results on the theory of costs for equivalence relations and groups and its applications to proving rigidity theorems for actions of free groups.

  16. Leaning in to "muddy" interviews

    DEFF Research Database (Denmark)

    Lippke, Lena; Tanggaard, Lene

    2014-01-01

    situated identities among the participants cross each other. We emphasize the value of daring to lean in to the muddiness of peopled research, use it as an analytical tool and present it in its imperfect form. This approach contributes to transparency in qualitative research, opens up the data in a new way......Over the last few decades, qualitative research has been acknowledged as a peopled practice in which subjectivities come into play. The main argument presented in this article is that qualitative research involves “muddy,” troublesome, interactional passages, because of a complex interplay between...... subjectivities, situated identities, emotions, and conversational genres. Based on ethnographic fieldwork at a Danish Vocational Educational Training College, we introduce the concept of “leaning in” to provide an analytical grasp of the “muddy” interactional tension field in an interview situation, in which...

  17. THE EFFECTS OF READING TOPIC AND TOPIC PREFERENCE ON READING COMPREHENSION

    Directory of Open Access Journals (Sweden)

    Hesty Widiastuty

    2011-09-01

    Full Text Available This study is aimed at investigating the interaction effect of reading topic and topic preference, the effect of reading topic, and the effect of topic preference on Physics score, Biology score, and Chemistry score of single cause-multiple effects text. The population of this study was the eleventh grade of IPA students of SMA Negeri 2 Kuala Kapuas in Academic Year 2008/2009. There were 64 students of two classes (XI IA1 and IX IA2 as the sample of this study chosen by using cluster random sampling. It was used experimental research with factorial experimental design. The data were processed and analyzed through these steps: taking the data, coding scoring, tabulating, analyzing the data by using statistic technique of ANOVA processed by using SPSS 15 and taking the conclusion based on the statistical result. The results show that: (1 there was significant interaction effect among reading topic and topic preference on Physics score, Biology score, and Chemistry score of single cause-multiple effects text, (2 there was no significance effect of reading topic of single cause-multiple effects text, and (3 there was no significance effect of topic preference on Physics score, Biology score, and Chemistry score of single cause-multiple effects text. Keywords: reading topic, topic preference, reading comprehension

  18. Modified personal interviews: resurrecting reliable personal interviews for admissions?

    Science.gov (United States)

    Hanson, Mark D; Kulasegaram, Kulamakan Mahan; Woods, Nicole N; Fechtig, Lindsey; Anderson, Geoff

    2012-10-01

    Traditional admissions personal interviews provide flexible faculty-student interactions but are plagued by low inter-interview reliability. Axelson and Kreiter (2009) retrospectively showed that multiple independent sampling (MIS) may improve reliability of personal interviews; thus, the authors incorporated MIS into the admissions process for medical students applying to the University of Toronto's Leadership Education and Development Program (LEAD). They examined the reliability and resource demands of this modified personal interview (MPI) format. In 2010-2011, LEAD candidates submitted written applications, which were used to screen for participation in the MPI process. Selected candidates completed four brief (10-12 minutes) independent MPIs each with a different interviewer. The authors blueprinted MPI questions to (i.e., aligned them with) leadership attributes, and interviewers assessed candidates' eligibility on a five-point Likert-type scale. The authors analyzed inter-interview reliability using the generalizability theory. Sixteen candidates submitted applications; 10 proceeded to the MPI stage. Reliability of the written application components was 0.75. The MPI process had overall inter-interview reliability of 0.79. Correlation between the written application and MPI scores was 0.49. A decision study showed acceptable reliability of 0.74 with only three MPIs scored using one global rating. Furthermore, a traditional admissions interview format would take 66% more time than the MPI format. The MPI format, used during the LEAD admissions process, achieved high reliability with minimal faculty resources. The MPI format's reliability and effective resource use were possible through MIS and employment of expert interviewers. MPIs may be useful for other admissions tasks.

  19. An interview guide for clinicians to identify a young disabled person's motivation to work.

    Science.gov (United States)

    Faber, B J M; Wind, H; Frings-Dresen, M H W

    2016-06-27

    The percentage of young people with disabilities who are employed is relatively low. Motivation is considered to be an important factor in facilitating or hindering their ability to obtain employment. We aimed to develop a topic list that could serve as an interview guide for professionals in occupational health care which would aid them in their discussion of work motivation-related issues with this group. We systematically searched Pubmed, PsychInfo and Picarta. Studies were included if they described aspects of work motivation and/or instruments that assess work motivation. Based on the results of our literature survey, we developed a list of topics that had been shown to be related to work motivation. Our search resulted in 12 articles describing aspects of work motivation and 17 articles describing instruments that assess work motivation. The aspects that we found were intrinsic motivation, extrinsic motivation, goal setting, self-efficacy, expectancy, values and work readiness. Based on this information we developed an interview guide that includes seven topic areas: intrinsic motivation, extrinsic motivation, goal setting, expectancy, values, self- efficacy, and work readiness. The topics within the interview guide and the literature survey data that is presented will shed light on the role that motivation plays on the work participation among young people with disabilities.

  20. STS-106 Crew Interviews: Scott D. Altman

    Science.gov (United States)

    2000-01-01

    Live footage of a preflight interview with Pilot Scott D. Altman is seen. The interview addresses many different questions including why Altman became a pilot, the events that led to his interest, his career path through the Navy, and then finally, his selection by NASA as an astronaut. Other interesting information discussed in this one-on-one interview was his work on the movie set of "Top Gun," the highlights of his Navy career, and possible shorter time frame turnarounds for missions. Altman also mentions the scheduled docking with the new International Space Station (ISS) after the arrival of the Zvezda Service Module.

  1. ANNUAL INTERVIEWS - 2000

    CERN Multimedia

    1999-01-01

    The procedures for the above [Administrative Circular 26(Rev. 2)] will be as for 1999.The Appraisal Report form template is available as follows:For Macintosh usersConnect to the server SRV4-Home in the Appletalk zone NOVELL (as GUEST or using your Novell username and password), and then use the volume PE Division Data Disk.The Word file 'MOAS FORM' is available in the folder COM, folder Public.For PC usersStart Word; in File + New, choose document 'CERN MOAS FORM' in CERN Template.In view of the wide use of the form template, and to reduce use of paper, only the first page, pre-printed with staff members' individual data, will be distributed to divisions on request. Otherwise, this data will be transmitted electronically only.Users of the electronic template are asked to be careful to copy accurately the personal data.Personnel DivisionTel. 74480

  2. Interview with Mike Shaughnessy

    Science.gov (United States)

    Rossman, Allan; Shaughnessy, Mike

    2013-01-01

    Mike Shaughnessy is Professor Emeritus of Mathematics and Statistics at Portland State University in Oregon. He served as co-chair for the Board for the Special Interest Group for Research in Mathematics Education of the American Educational Research Association from 2005-2007. A member of the Board of Directors of the National Council of Teachers…

  3. Interview with Deborah Nolan

    Science.gov (United States)

    Rossman, Allan; Nolan, Deborah

    2015-01-01

    Deborah Nolan is Professor of Statistics and holds the Zaffaroni Family Chair in Undergraduate Education at the University of California-Berkeley, where she has also served as Associate Dean of Mathematical and Physical Sciences. She is a Fellow of the American Statistical Association and the Institute of Mathematical Statistics. This interview…

  4. INTERVIEW WITH MICHAEL WELKER

    African Journals Online (AJOL)

    Michael Welker recently visited the University of the Free State. As. Senior Professor and Director of the Research Centre for International and Interdisciplinary Theology at the University of Heidelberg, Welker recently led a project and edited a book. (with Michael Beintker and Albert de. Lange) on the European Reformation ...

  5. Vint Cerf. TECHNOS Interview.

    Science.gov (United States)

    Raney, Mardell

    1998-01-01

    Discussion with Vinton G. Cerf, widely known as father of the Internet and creator of the original email system, focuses on societal implications of the Internet; filtering; hypertext; email; the need for a global legal framework; e-commerce and potential for Web-based businesses; and implications of the Internet for education. (LRW)

  6. Elements of programming interviews the insider's guide

    CERN Document Server

    Aziz, Adnan; Prakash, Amit

    2015-01-01

    This is a larger-format version of Elements of Programming Interviews. The language is C++. Specifically, the font size is larger, and the page size is 7"x10" (the regular format uses 6"x9"). The content is identical. Have you ever... Wanted to work at an exciting futuristic company? Struggled with an interview problem that could have been solved in 15 minutes? Wished you could study real-world computing problems? If so, you need to read Elements of Programming Interviews (EPI). EPI is your comprehensive guide to interviewing for software development roles. The core of EPI is a collection of over 250 problems with detailed solutions. The problems are representative of interview questions asked at leading software companies. The problems are illustrated with 200 figures, 300 tested programs, and 150 additional variants. The book begins with a summary of the nontechnical aspects of interviewing, such as strategies for a great interview, common mistakes, perspectives from the other side of the table,...

  7. Online interviewing with interpreters in humanitarian contexts.

    Science.gov (United States)

    Chiumento, Anna; Machin, Laura; Rahman, Atif; Frith, Lucy

    2018-12-01

    Recognising that one way to address the logistical and safety considerations of research conducted in humanitarian emergencies is to use internet communication technologies to facilitate interviews online, this article explores some practical and methodological considerations inherent to qualitative online interviewing. Reflections from a case study of a multi-site research project conducted in post-conflict countries are presented.  Synchronous online cross-language qualitative interviews were conducted in one country.  Although only a small proportion of interviews were conducted online (six out of 35), it remains important to critically consider the impact upon data produced in this way. A range of practical and methodological considerations are discussed, illustrated with examples.  Results suggest that whilst online interviewing has methodological and ethical potential and versatility, there are inherent practical challenges in settings with poor internet and electricity infrastructure.  Notable methodological limitations include barriers to building rapport due to partial visual and non-visual cues, and difficulties interpreting pauses or silences. Drawing upon experiences in this case study, strategies for managing the practical and methodological limitations of online interviewing are suggested, alongside recommendations for supporting future research practice.  These are intended to act as a springboard for further reflection, and operate alongside other conceptual frameworks for online interviewing.

  8. Interview with Claudia Roden

    OpenAIRE

    Mac Con Iomaire, Máirtín

    2016-01-01

    Claudia Roden is an award winning cookbook writer and cultural anthropologist based in the United Kingdom. She is co-chair with Paul Levy of the Oxford Symposium on Food and Cookery. She was born in 1936 in Cairo, Egypt. After completing her formal education in Paris, she moved to London to study at Saint Martin's School of Art. She began her career as a painter, but soon realised following the Suez Crisis that the Jewish food culture of Egypt was disappearing which led her to begin her study...

  9. Interview with Kathleen Fitzpatrick

    Directory of Open Access Journals (Sweden)

    Andrés Lomeña Cantos

    2012-12-01

    Full Text Available Kathleen Fitzpatrick, born in 1967, teaches Media Studies in Pomona University (California, coordinator of the MediaCommons plattaform and one of the most remarkable Digital Humantties academic. His first book The Anxiety of Obsolescence (http://www.anxietyofobsolescence.com reflects on some novelist technophilia as a mecanism to maintain his privilege status inside a media ecology increasingly comptetive. His next essay, Planned obsolecence (http://www.plannedobsolescence.net, extends his critics to the old humanities role and meditate about pressent and future of academic publications.

  10. Interview with Heribert Hirt.

    Science.gov (United States)

    Hirt, Heribert

    2016-01-01

    As a son of an engineer who traveled widely during his career, Heribert Hirt began his life in the exotic country of Iran, before receiving his high-school education in Germany and then studying biochemistry at the University of Cape Town and then later at the University of Vienna, from where he received his PhD in 1987. He then worked as a postdoctoral fellow in Vienna, Oxford, and Wageningen, before starting his own group at the University of Vienna in 1993. It was also in Vienna that he became professor of genetics in 1997, followed by vice-director of the Gregor Mendel Institute of Plant Molecular Biology, and later head of the Plant Molecular Biology Department of the University of Vienna. In 2007, he decided that it was time for new challenges and accepted an appointment in France to direct the Paris-based INRA-CNRS Plant Genomics Institute for the following 7 years. In 2014, Heribert embarked on yet another challenge by accepting the role to head up the Center for Desert Agriculture at King Abdullah University of Sciences and Technology (KAUST) in Saudi Arabia. Copyright © 2015 Elsevier Ltd. All rights reserved.

  11. news interview talk: Organisational properties

    African Journals Online (AJOL)

    informational and debate news interviews in the political sphere manifested themselves in the. South African data. ... the fact that Clayman's (1991) analysis focuses solely on a corpus of political-news interview talk. Given that an ..... through the dry seasons, a gene from an arctic fish could protect tomatoes from frost.

  12. Aikido Politics in Interview Interaction.

    Science.gov (United States)

    Chew, Phyllis Ghim Lian

    1995-01-01

    Analyzes how less powerful subjects in an unequal encounter, an admission interview in an educational institution, were able to counter the power directed at them by the more powerful subject through "aikido" strategies. In the context of the interview, harmonizing with the ideological discursive formation of the institution in question…

  13. BUSINESS ETIQUETTE IN JOB INTERVIEW

    Directory of Open Access Journals (Sweden)

    AGEEVA JULIA VICTOROVNA

    2015-01-01

    Full Text Available The article presents the analysis of job interview transcripts from the perspective of dominant communicant’s (HR manager communicative behavior. The interviewer uses various etiquette forms that facilitate a more productive dialogue and stipulate cooperative strategies and tactics in order to achieve the main goal - to determine whether the job applicant meets the requirements of the employer.

  14. Motivational Interviewing in Relational Context

    Science.gov (United States)

    Miller, William R.; Rose, Gary S.

    2010-01-01

    Responds to M. Stanton's comments on the current author's original article. One of the puzzles of motivational interviewing is why it works at all. How can it be that an individual interview or two yields change in a long-standing problem behavior even without any effort to alter social context? The time involved is such a tiny part of the…

  15. Det foto-eliciterede interview

    DEFF Research Database (Denmark)

    Rasmussen, Kim

    2017-01-01

    Det foto-eliciterede interview fremkalder informationer og fortællinger ud af fotografier, og støtter børn i at ytre sig.......Det foto-eliciterede interview fremkalder informationer og fortællinger ud af fotografier, og støtter børn i at ytre sig....

  16. An Interview with Noam Chomsky

    Science.gov (United States)

    Jack, Gavin

    2006-01-01

    This article presents a transcript of an interview that the author conducted with Noam Chomsky. In this interview, Chomsky talks about language acquisition and his theory of Universal Grammar. He then explains how the USA best exemplifies the individualist national culture. He also cites the challenges researchers should address in intercultural…

  17. L'esperanto et le plurilinguisme de l'avenir: Entretien avec Umberto Eco (Esperanto and the Multilingualism of the Future: Interview with Umberto Eco).

    Science.gov (United States)

    Ertl, Istvan; Lo Jacomo, Francois

    Excerpts of the interview with Umberto Eco, a prominent semiotician, by two specialists in Esperanto focused on the role of translation, which paradoxically appears to be essential for the existence of a universal language such as Esperanto. Topics addressed include the perceived conflict between the existence of a "perfect," universal…

  18. Crew Interviews: Treschev

    Science.gov (United States)

    2002-01-01

    Sergei Treschev is a Cosmonaut of the Rocket Space Corporation Energia, (RSC), from Volynsky District, Lipetsk Region (Russia). He graduated from Moscow Energy Institute. After years of intense training with RSC Energia, he was selected as International Space Station (ISS) Increment 5 flight engineer. The Expedition-Five crew (two Russian cosmonauts and one American astronaut) will stay on the station for approximately 5 months. The Multipurpose Logistics Module, or MPLM, will carry experiment racks and three stowage and resupply racks to the station. The mission will also install a component of the Canadian Arm called the Mobile Base System (MBS) to the Mobile Transporter (MT) installed during STS-110. This completes the Canadian Mobile Servicing System, or MSS. The mechanical arm will now have the capability to "inchworm" from the U.S. Lab fixture to the MSS and travel along the Truss to work sites.

  19. Interview with Agnieszka Zalewska

    CERN Multimedia

    Antonella Del Rosso and Katarina Anthony

    2012-01-01

    Yesterday, the CERN Council elected its new President to take over as of 2013. Agnieszka Zalewska is the first woman and the first Polish physicist to fill this position.   Agnieszka Zalewska. Your involvement with CERN dates back to the 70s. Tell us about your career at CERN. I got involved with CERN in 1970, when I joined the Krakow group working on the K+ proton interactions recorded at the 2 metre Bubble chamber experiment at the PS. This was for my diploma thesis. I continued my collaboration with CERN during my PhD, working on the analysis of high-multiplicity events from the same experiment. After receiving my PhD in 1975, I came to CERN for the first time to work in the S136 experiment. I was then involved in the WA3 experiment and, for over 15 years, in the DELPHI experiment at LEP. It was a very interesting time because, in the early 80s, work had begun on the silicon vertex detector with VLSI read-out electronics in Peter Weilhammer's and Bernard Hyams’ group. ...

  20. INTERVIEW WITH VICENTE TALANQUER

    Directory of Open Access Journals (Sweden)

    Olga Lucia Castiblanco Abril

    2017-01-01

    de formación docente dentro de este y no en el de educación. Así surgió el programa de formación en el que actualmente trabajo. Dentro de este programa doy cursos sobre planeación y evaluación en educación de las ciencias, pero también doy cursos de química en los niveles introductorios. Cuando fui contratado en la Universidad de Arizona tuve más tiempo para dedicarme a la investigación educativa en química y crear un grupo de investigación en esa área. También comencé a investigar sobre pensamiento docente con los colegas que creamos el programa de formación de profesores. Este programa se ofrece solo a nivel de pregrado, pues en mi universidad la formación de maestros a nivel posgrado ocurre en el colegio de educación. Los docentes que quieren hacer posgrado en el colegio de ciencias solo pueden completar maestrías y doctorados en cada disciplina científica, pero sin el componente de educativo.

  1. Interview with Alison Goate.

    Science.gov (United States)

    Goate, Alison

    2008-12-01

    Alison M Goate is the Samuel & Mae S Ludwig Professor of Genetics in Psychiatry, Professor of Genetics and Professor of Neurology at Washington University School of Medicine in St Louis (MO, USA). Dr Goate studied for her undergraduate degree in biochemistry at the University of Bristol (UK) and received her graduate training at Oxford University (UK). She performed postdoctoral studies with Professor Theodore Puck, Professor Louis Lim and Dr John Hardy before receiving a Royal Society University Research Fellowship to support her independent research program at St Mary's Hospital Medical School in London. In 1991, Dr Goate and colleagues reported the first mutation linked to an inherited form of Alzheimer's disease, in the amyloid precursor protein (APP) gene on chromosome 21. The mutation was found to be linked to inherited cases of early-onset Alzheimer's disease. In 1992, Dr Goate moved to Washington University as an Associate Professor in Genetics and Psychiatry. Dr Goate and colleagues have since identified mutations in four other genes, including two that cause Alzheimer's disease and two that cause the related dementia frontotemporal dementia. In addition to her work on dementia, Dr Goate's laboratory also studies the genetics of alcohol and nicotine dependence. Dr Goate has received numerous awards including the Potamkin Award from the American Academy of Neurology, the Zenith Award from the Alzheimer's Association, the Senior Investigator Award from the Metropolitan Life Foundation, the St Louis Academy of Science Innovation Award and the Carl and Gerty Cori Faculty Achievement Award at Washington University. Dr Goate has been a member of many scientific Review Boards and currently serves on the Editorial Boards of several journals.

  2. A Study on Language Competence and Use by Ethnic Kyrgyz People in Post-Soviet Kyrgyzstan: Results from Interviews

    OpenAIRE

    ODAGIRI, Nami

    2012-01-01

    In this article the author discusses the case of Kyrgyzstan and examines the language use of ethnic Kyrgyz people. Based on the results of semi-structured interviews with thirteen ethnic Kyrgyz people, features of Kyrgyz language use are clarified. After the dissolution of the Soviet Union, the titular languages of each ex-Soviet state were promoted as ‘state languages’ and positioned as a symbol of national integration. Previous studies on this topic indicate the tendency that the influence ...

  3. How University Students View Themselves as Literate Beings: Implementing Literacy Self-Evaluation Interviews in the United States and Hong Kong

    Science.gov (United States)

    Kim, Koomi J.; Ng, Patrick; Fahrenbruck, Mary L.

    2015-01-01

    This study investigates how university students in the US and Hong Kong perceive themselves as literate and biliterate beings. All the participants in Hong Kong are biliterate in at least two languages (including Cantonese, Mandarin, and English), whereas only 40% of the U.S. participants are biliterate in at least two languages (including…

  4. Entrevistas com profissionais como atividade de ensino-aprendizagem desejável na formação do psicólogo Interviewing professionals as a desirable teaching-learning activity for psychology students

    Directory of Open Access Journals (Sweden)

    Waldir Bettoi

    2002-01-01

    Full Text Available O objetivo deste estudo foi o de refletir sobre possíveis interações de atividades de ensino-aprendizagem, especialmente entrevistas feitas com psicólogos sobre sua profissão, com concepções de alunos sobre sua futura profissão de psicólogo(a. Foram analisados questionários, respondidos pelos alunos no início e no final de seu contato com a disciplina, transcrições de entrevistas com psicólogos realizadas pelos alunos e comentários escritos que eles fizeram sobre as entrevistas. Procurou-se, a partir daí, delinear possíveis contribuições das entrevistas na construção de imagens dos alunos sobre a profissão. A análise do conjunto de informações indica que as entrevistas e a reflexão orientada sobre elas podem contribuir para a construção de uma imagem do psicólogo mais próxima de alguém que realiza ações profissionais significativas, ao mesmo tempo que propiciam aos alunos acesso a informações sobre possibilidades de atuação antes desconhecidas, constituindo-se em atividade relevante em sua formação.This investigation led to reflections about the possible interactions of some teaching - learning activities (in particular, the student's activity of interviewing professionals working in different areas of application with students' conceptions about their future profession as Psychologists. The analysis was based on questionnaires answered by the students at the beginning and at the end of the course, transcriptions of the interviews they made and their written comments on these interviews. An outline of the possible contributions of the interviews to the students' constructing of images about profession is presented. The interviews possibly contributed to the constructing of a conception about a professional, revealed at the end of the course, in which he/she is seen as someone who leads significant professional actions; they may also bring to the students a varied set of information regarding new

  5. Advanced verification topics

    CERN Document Server

    Bhattacharya, Bishnupriya; Hall, Gary; Heaton, Nick; Kashai, Yaron; Khan Neyaz; Kirshenbaum, Zeev; Shneydor, Efrat

    2011-01-01

    The Accellera Universal Verification Methodology (UVM) standard is architected to scale, but verification is growing and in more than just the digital design dimension. It is growing in the SoC dimension to include low-power and mixed-signal and the system integration dimension to include multi-language support and acceleration. These items and others all contribute to the quality of the SOC so the Metric-Driven Verification (MDV) methodology is needed to unify it all into a coherent verification plan. This book is for verification engineers and managers familiar with the UVM and the benefits it brings to digital verification but who also need to tackle specialized tasks. It is also written for the SoC project manager that is tasked with building an efficient worldwide team. While the task continues to become more complex, Advanced Verification Topics describes methodologies outside of the Accellera UVM standard, but that build on it, to provide a way for SoC teams to stay productive and profitable.

  6. Topics in inflationary cosmology

    International Nuclear Information System (INIS)

    Kahn, R.N.

    1985-01-01

    This thesis examines several topics in the theory of inflationary cosmology. It first proves the existence of Hawking Radiation during the slow-rolling period of a new inflationary universe. It then derives and somewhat extends Bardeen's gauge invariant formalism for calculating the growth of linear gravitational perturbations in a Friedmann-Robertson-Walker cosmological background. This formalism is then applied, first to several new inflationary universe models all of which show a Zel'dovich spectrum of fluctuations, but with amplitude sigma(100 4 ) above observational limits. The general formalism is next applied to models that exhibit primordial inflation. Fluctuations in these models also exhibit a Zel'dovich spectrum here with an acceptable amplitude. Finally the thesis presents the results of new, numerical calculations. A classical, (2 + 1) dimensional computer model is developed that includes a Higgs field (which drives inflation) along with enough auxiliary fields to generate dynamically not only a thermal bath, but also the fluctuations that naturally accompany that bath. The thesis ends with a discussion of future prospects

  7. Digital Social Network Mining for Topic Discovery

    Science.gov (United States)

    Moradianzadeh, Pooya; Mohi, Maryam; Sadighi Moshkenani, Mohsen

    Networked computers are expanding more and more around the world, and digital social networks becoming of great importance for many people's work and leisure. This paper mainly focused on discovering the topic of exchanging information in digital social network. In brief, our method is to use a hierarchical dictionary of related topics and words that mapped to a graph. Then, with comparing the extracted keywords from the context of social network with graph nodes, probability of relation between context and desired topics will be computed. This model can be used in many applications such as advertising, viral marketing and high-risk group detection.

  8. Tips for a physician in getting the right job, part VI: some possible interview questions for an executive position.

    Science.gov (United States)

    Harolds, Jay A

    2014-01-01

    This article examines numerous general questions and possible responses that will be of special interest for those doctors interviewing for an administrative position. These queries will be presented under the topic headings of why do you want to change jobs, what are your strong and weak points, what are your credentials to do this job well, and what are your career objectives. However, some of these questions and answers will also be helpful to those physicians seeking a clinical job. Additional types of questions and answers, such as those found in behavioral, situational, and stress interviews, will be discussed in subsequent articles.

  9. Interview

    International Nuclear Information System (INIS)

    Rozes, Stephane

    2014-01-01

    Programmed for this year, the debate for the Act concerning energy transition comes at a crucial moment in Francois Hollande's five year term of office. What is in store for the programme of renewable energy development? How will France reduce its nuclear energy share? Consultant Stephane Rozes invites elected representatives and State authorities to avoid being dogmatic. (author)

  10. Interview

    DEFF Research Database (Denmark)

    Sarauw, Laura Louise; Hollesen, Laika

    2011-01-01

    Det såkaldte humboldtske universitetsideal står i frit fald. Så det burde ikke komme som nogen overraskelse, at det demokratiske fundament slår revner. Det kommer i hvert fald ikke bag på Laura Louise Sarauw fra Københavns Universitet, der i sin ph.d.-afhandling har sat stort spørgsmålstegn ved d...

  11. [Motivational interviewing with alcohol-dependent patients].

    Science.gov (United States)

    Spaeth, Michael; Bleich, Stefan; Hillemacher, Thomas

    2017-09-01

    Motivational interviewing with alcohol-dependent patients Alcohol-dependent patients do not need to be motivated from the outside. They are mostly ambivalent, and the inner voice, which already speaks for change (change talk), is heard through motivational interviewing, carefully strengthened and developed together with the patient. The practitioner has to deal with the human spirit of motivational interviewing and should be able to communicate with empathy, respect, congruence, and openness. The patient's autonomy should always be maintained. Advice is only given upon request. The conversation style is directive-guiding instead of authoritariansteering. OARS and the EPE principle are the motivational interviewing basics, which are consistently applied over 4 processes of motivational interviewing: engaging, focusing, evocing, and planning. The likelihood of change talk increases as soon as discrepancies between life goals and alcohol consumption emerge. An increased rate of change talk makes a change in behavior more likely. If a patient argues against change (sustain talk), one should not confront, but should consistently work with reflections, reframing, and an emphasis on autonomy. Motivational interviewing can be applied in different settings and populations, should be learned by the entire team (best professional guidance) in teamwork, and be subjected to a critical and constant evaluation. Georg Thieme Verlag KG Stuttgart · New York.

  12. Analyses of Research Topics in the Field of Informetrics Based on the Method of Topic Modeling

    Directory of Open Access Journals (Sweden)

    Sung-Chien Lin

    2014-07-01

    Full Text Available In this study, we used the approach of topic modeling to uncover the possible structure of research topics in the field of Informetrics, to explore the distribution of the topics over years, and to compare the core journals. In order to infer the structure of the topics in the field, the data of the papers published in the Journal of Informetricsand Scientometrics during 2007 to 2013 are retrieved from the database of the Web of Science as input of the approach of topic modeling. The results of this study show that when the number of topics was set to 10, the topic model has the smallest perplexity. Although data scopes and analysis methodsare different to previous studies, the generating topics of this study are consistent with those results produced by analyses of experts. Empirical case studies and measurements of bibliometric indicators were concerned important in every year during the whole analytic period, and the field was increasing stability. Both the two core journals broadly paid more attention to all of the topics in the field of Informetrics. The Journal of Informetricsput particular emphasis on construction and applications ofbibliometric indicators and Scientometrics focused on the evaluation and the factors of productivity of countries, institutions, domains, and journals.

  13. Philosophy in the Public Interest: An Interview with Martha C. Nussbaum.

    Science.gov (United States)

    Miller, Margaret A.

    2002-01-01

    Presents a wide-ranging interview with one of America's most prominent philosophers, whose reputation is due not only to her productivity, but to her willingness to speak to broad audiences on topics of public importance. (EV)

  14. Topical Melatonin for Treatment of Androgenetic Alopecia

    OpenAIRE

    Fischer, Tobias W; Tr?eb, Ralph M; H?nggi, Gabriella; Innocenti, Marcello; Elsner, Peter

    2012-01-01

    Background: In the search for alternative agents to oral finasteride and topical minoxidil for the treatment of androgenetic alopecia (AGA), melatonin, a potent antioxidant and growth modulator, was identified as a promising candidate based on in vitro and in vivo studies. Materials and Methods: One pharmacodynamic study on topical application of melatonin and four clinical pre-post studies were performed in patients with androgenetic alopecia or general hair loss and evaluated by standardise...

  15. Selected Interviews with Doug Lowy

    Science.gov (United States)

    In these selected interviews, Douglas R. Lowy, M.D., Deputy Director of the National Cancer Institute (NCI), talks with media and scientific institutions about basic science, clinical research, and the work of NCI.

  16. Interview with Martha C. Nussbaum

    Directory of Open Access Journals (Sweden)

    Fabrizia Abbate

    2012-05-01

    Full Text Available Here's the interview granted by Martha Nussbaum to Fabrizia Abbate about the role of preference in social dynamics. How important are aesthetic preferences in the development of moral attitudes and choices ?

  17. An Interview with Stella Adler.

    Science.gov (United States)

    Rotte, Joanna

    2002-01-01

    Details the life of Stella Adler, an actor, director, and teacher who studied with Stanislavsky. Includes an interview (conducted in 1974) which touches on her influences, teachers, theatre groups, and styles of acting. (PM)

  18. Recent developments in topical thrombins.

    Science.gov (United States)

    Kessler, Craig M; Ortel, Thomas L

    2009-07-01

    Managing blood loss is part of the surgeon's responsibility during surgical procedures, and a variety of therapeutic strategies are available to help accomplish this. Topical haemostatic agents are among the agents used to control surgical bleeding and locally arrest blood flow. Bovine thrombin is a commonly used topical haemostatic agent; however, its use has been associated with potential risks, including well-documented cases of antibody-mediated coagulopathy. This coagulopathy develops as a consequence of antibody formation directed against bovine thrombin, other bovine coagulation proteins, and their human orthologs. The fact that a coagulopathy can result in association with the use of bovine plasma-derived thrombin preparations prompted the FDA to require pharmaceutical companies to place a black-box warning in their prescribing information for products containing bovine plasma-derived thrombin. Recently, human plasma-derived thrombin and recombinant human thrombin have been approved by the FDA with the expectation that they will be less immunogenic than the bovine-derived product. In clinical studies, purified human plasma-derived thrombin and recombinant thrombin have demonstrated equivalent efficacy and safety, with improved immunogenicity profiles compared with bovine-derived thrombin agents. Well-designed and adequately powered clinical trials should be conducted to indicate whether human thrombin products would improve the risk-benefit and cost-benefit profiles for surgeries complicated by excessive bleeding.

  19. An Interview with Zvi Griliches

    OpenAIRE

    Alan B. Krueger; Timothy Taylor

    2000-01-01

    Alan Krueger and Timothy Taylor interviewed Zvi Griliches, Paul M. Warburg Professor of Economics at Harvard University, at his home near the Harvard campus on June 21, 1999. The interview touches on his harrowing journey from Lithuania to Chicago; years at the University of Chicago; the move to Harvard University; work on diffusion and technology and on returns to education; thoughts on the data infrastructure; government service and economic research; and hobbies.

  20. Professionalism in intercultural job interviews

    DEFF Research Database (Denmark)

    Jensen, Iben

    2005-01-01

    The article is a slightly revised manuscript from my keynote speech at the NIC conference 2003 in Göteborg, Sweden. The aim of the speech was to put forward research towards a critical intercultural multiperspectivism in order to understand professional intercultural communication in multicultura...... societies. This is discussed in relation to a case, a job interview with an untrained Danish interviewer and a Chinese candidate....