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Sample records for interreg iiia sr

  1. Interreg IIIA SR - AT project SOLARSTRAT. Results of the interviews with experts on solar-thermal energy utilization. Possibilities of support to thermal-solar systems installation

    International Nuclear Information System (INIS)

    Ilias, I.

    2005-01-01

    In this presentation author presented the results of collecting of important data for solar-thermal market scenario modelling through interviews with Slovak stakeholders. Interviews with Slovak experts on thermal-solar energy utilisation represents important project activity in order to give a general review of current status of the market in target Bratislava region and to collect important data for next market analyses, which will be prepared by Austrian partner - IFAST. The results of face-to-face interviews and filled questionnaires can be generally presented as follows: - public attitude towards the renewable energy sources and solar energy utilisation is slowly getting better in Slovakia; - evaluating public awareness only 15% share of population is able to consider the possibilities of thermal-solar technologies; - expected increase of fossil fuels and energy prices will help to spread of thermal-solar systems through shorten the pay-back period of investment while prices of thermal-solar systems will increase only slightly; - also expected increase of political and economic public awareness about energy production and demand on thermal-solar systems will help to promote the further development of solar energy utilisation in Slovakia. Respondent were also evaluating the main barriers for better solar energy utilisation: (1) Weak public awareness, no systematic information campaign (examples from real life); (2) Missing support to installation for physical persons, no tax allowances; (3) High investment costs; (4) Unfriendly legislation Other important barriers for better development of the sector were presented. E.g. assembling companies cannot afford effective promotion, only big producers are able to fund the marketing on their products, which are mainly expensive systems. Public is still considering solar systems as too expensive ('I can't afford it'). Renewable energy sources (RES) are often presented as the alternative to nuclear energy - this argument is not working in Slovak conditions. Slovaks are thinking economically, not ecologically

  2. Interreg IIIA SR - AT project SOLARSTRAT. Results of the interviews with experts on solar-thermal energy utilization. Possibilities of support to thermal-solar systems installation

    International Nuclear Information System (INIS)

    Ilias, I.

    2005-01-01

    In this presentation author presented the results of collecting of important data for solar-thermal market scenario modelling through interviews with Slovak stakeholders. Interviews with Slovak experts on thermal-solar energy utilisation represents important project activity in order to give a general review of current status of the market in target Bratislava region and to collect important data for next market analyses, which will be prepared by Austrian partner - IFAST. The results of face-to-face interviews and filled questionnaires can be generally presented as follows: - public attitude towards the renewable energy sources and solar energy utilisation is slowly getting better in Slovakia; - evaluating public awareness only 15% share of population is able to consider the possibilities of thermal-solar technologies; - expected increase of fossil fuels and energy prices will help to spread of thermal-solar systems through shorten the pay-back period of investment while prices of thermal-solar systems will increase only slightly; - also expected increase of political and economic public awareness about energy production and demand on thermal-solar systems will help to promote the further development of solar energy utilisation in Slovakia. Respondents were also evaluating the main barriers for better solar energy utilisation: (1) Weak public awareness, no systematic information campaign (examples from real life); (2) Missing support to installation for physical persons, no tax allowances; (3) High investment costs; (4) Unfriendly legislation. Other important barriers for better development of the sector were presented. E.g. assembling companies cannot afford effective promotion, only big producers are able to fund the marketing on their products, which are mainly expensive systems. Public is still considering solar systems as too expensive ('I can't afford it'). Renewable energy sources (RES) are often presented as the alternative to nuclear energy - this argument is not working in Slovak conditions. Slovaks are thinking economically, not ecologically

  3. The Interreg IV Italia-Austria "SeismoSAT" project: connecting seismic data centers via satellite

    Science.gov (United States)

    Pesaresi, D.; Lenhardt, W.; Rauch, M.; Živčić, M.; Steiner, R.; Fabris, P.; Bertoni, M.

    2014-06-01

    Since 2002 OGS (Istituto Nazionale di Oceanografia e di Geofisica Sperimentale) in Udine (Italy), the Zentralanstalt für Meteorologie und Geodynamik (ZAMG) in Vienna (Austria), and the Agencija Republike Slovenije za Okolje (ARSO) in Ljubljana (Slovenia) are using the Antelope software suite as the main tool for collecting, analyzing, archiving and exchanging seismic data in real time, initially in the framework of the EU Interreg IIIA project "Trans-national seismological networks in the South-Eastern Alps" (Bragato et al., 2004, 2010). The data exchange has proved to be effective and very useful in case of seismic events near the borders between Italy, Austria and Slovenia, where the poor single national seismic networks coverage precluded a correct localization, while the usage of common data from the integrated networks improves considerably the overall reliability of real time seismic monitoring of the area (Fig. 1). At the moment the data exchange between the seismic data centers relies on their internet connections: this however is not an ideal condition for civil protection purposes, since the reliability of standard internet connections is poor. For this reason in 2012 the Protezione Civile della Provincia Autonoma di Bolzano in Bolzano (PCBZ, Italy), OGS, ZAMG subsidiary in Tirol (ZAMG Tirol) and ARSO joined in the Interreg IV Italia-Austria Project "SeismoSAT" (Progetto SeismoSAT, 2012) aimed in connecting the seismic data centers in real time via satellite. ARSO does not belong to the Interreg Italia-Austria region: for this reason ARSO joined the SeismoSAT project as an "associated partner", which, according to Interreg rules can not be funded. ARSO participation in the project is therefore at the beginning limited in benefiting only indirectly from improvement in the robustness of the data exchange between the other data centers, while eventually fully taking part in the project if other sources of funding will be available. The project is in a

  4. Cervical Cancer Stage IIIA

    Science.gov (United States)

    ... hyphen, e.g. -historical Searches are case-insensitive Cervical Cancer Stage IIIA Add to My Pictures View /Download : ... 1275x1275 View Download Large: 2550x2550 View Download Title: Cervical Cancer Stage IIIA Description: Stage IIIA cervical cancer; drawing ...

  5. Experimental data report for transient flow calibration facility tests IIIA101, IIIA102, IIIA201, and IIIA202

    International Nuclear Information System (INIS)

    Wambach, J.L.

    1980-01-01

    Thermal-hydraulic response data are presented for the transient performance tests of an ECC pitot tube rake (IIIA201, IIIA202) and both an ECC pitot tube rake and modular drag disc-turbine transducer (DTT) rake (IIIA101, IIIA102). The tests were conducted in a system which provided full scale simulation of the pressure vessel and intact loop cold leg piping of the Loss of Fluid Test Facility (LOFT). A load cell system was used to provide a reference mass flow rate measurement

  6. Ultrasonographic findings of type IIIa biliary atresia

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Seung Seob; Kim, Myung Joon; Lee, Mi Jung; Yoon, Choon Sik; Han, Seok Joo; Koh, Hong [Dept. of Radiology, Research Institute of Radiological Science, Severance Hospital, Yensei University College of Medicine, Seoul (Korea, Republic of)

    2014-12-15

    To describe the ultrasonographic (US) findings of type IIIa biliary atresia. We retrospectively reviewed a medical database of patients pathologically confirmed to have biliary atresia, Kasai type IIIa, between January 2002 and May 2013 (n=18). We evaluated US findings including the visible common bile duct (CBD), triangular cord thickness, gallbladder size and shape, and subcapsular flow on color Doppler US; laboratory data; and pathological hepatic fibrosis grades. We divided them into two groups-those with visible (group A) and invisible (group B) CBD on US-and compared all parameters between the two groups. CBD was visible on US in five cases (27.8%; group A) and invisible in 13 cases (72.2%; group B). US was performed at an earlier age in group A than in group B (median, 27 days vs. 60 days; P=0.027) with the maximal age of 51 days. A comparison of the US findings revealed that the triangular cord thickness was smaller (4.1 mm vs. 4.9 mm; P=0.004) and the gallbladder length was larger (20.0 mm vs. 11.7 mm; P=0.021) in group A. The gallbladder shape did not differ between the two groups, and the subcapsular flow was positive in all cases of both groups. There was no significant difference in the laboratory data between the two groups. Upon pathological analysis, group A showed low-grade and group B showed low- to high-grade hepatic fibrosis. When CBD is visible on US in patients diagnosed with type IIIa biliary atresia, other US features could have a false negative status. A subcapsular flow on the color Doppler US would be noted in the type IIIa biliary atresia patients.

  7. Ultrasonographic findings of type IIIa biliary atresia

    International Nuclear Information System (INIS)

    Kim, Seung Seob; Kim, Myung Joon; Lee, Mi Jung; Yoon, Choon Sik; Han, Seok Joo; Koh, Hong

    2014-01-01

    To describe the ultrasonographic (US) findings of type IIIa biliary atresia. We retrospectively reviewed a medical database of patients pathologically confirmed to have biliary atresia, Kasai type IIIa, between January 2002 and May 2013 (n=18). We evaluated US findings including the visible common bile duct (CBD), triangular cord thickness, gallbladder size and shape, and subcapsular flow on color Doppler US; laboratory data; and pathological hepatic fibrosis grades. We divided them into two groups-those with visible (group A) and invisible (group B) CBD on US-and compared all parameters between the two groups. CBD was visible on US in five cases (27.8%; group A) and invisible in 13 cases (72.2%; group B). US was performed at an earlier age in group A than in group B (median, 27 days vs. 60 days; P=0.027) with the maximal age of 51 days. A comparison of the US findings revealed that the triangular cord thickness was smaller (4.1 mm vs. 4.9 mm; P=0.004) and the gallbladder length was larger (20.0 mm vs. 11.7 mm; P=0.021) in group A. The gallbladder shape did not differ between the two groups, and the subcapsular flow was positive in all cases of both groups. There was no significant difference in the laboratory data between the two groups. Upon pathological analysis, group A showed low-grade and group B showed low- to high-grade hepatic fibrosis. When CBD is visible on US in patients diagnosed with type IIIa biliary atresia, other US features could have a false negative status. A subcapsular flow on the color Doppler US would be noted in the type IIIa biliary atresia patients.

  8. Opportunities and Difficulties in the Implementation of Projects Financed Through the Interreg IVC Program in Romania. Case Study: The Project "Public Policies and Social Enterprises"

    Directory of Open Access Journals (Sweden)

    Daniela PÎRVU

    2011-02-01

    Full Text Available In Europe today, economic success is often dependent on a region’s capacity to develop networks with other regions. Cooperation and experience sharing between regions can be a key trigger in stimulating a dynamic, forwardlooking regional development process. The EU has an important role to play in brokering and supporting partnerships between regions within the Union. Thousands of projects developed over many years under the INTERREG initiative have demonstrated the benefits for regions of working in partnership, sharing ideas and charting new and innovative ways of harnessing European investment. The analysis of the implementation of the projects financed through the INTERREG IVC Program proves that the development of the interregional European cooperation is constrained by the practical difficulties generated by various administrative systems and by the differences among competences on the levels of the public administration of the European Union member states.

  9. Natural Progression of Canine Glycogen Storage Disease Type IIIa.

    Science.gov (United States)

    Brooks, Elizabeth D; Yi, Haiqing; Austin, Stephanie L; Thurberg, Beth L; Young, Sarah P; Fyfe, John C; Kishnani, Priya S; Sun, Baodong

    2016-02-01

    Glycogen storage disease type IIIa (GSD IIIa) is caused by a deficiency of glycogen debranching enzyme activity. Hepatomegaly, muscle degeneration, and hypoglycemia occur in human patients at an early age. Long-term complications include liver cirrhosis, hepatic adenomas, and generalized myopathy. A naturally occurring canine model of GSD IIIa that mimics the human disease has been described, with progressive liver disease and skeletal muscle damage likely due to excess glycogen deposition. In the current study, long-term follow-up of previously described GSD IIIa dogs until 32 mo of age (n = 4) and of family-owned GSD IIIa dogs until 11 to 12 y of age (n = 2) revealed that elevated concentrations of liver and muscle enzyme (AST, ALT, ALP, and creatine phosphokinase) decreased over time, consistent with hepatic cirrhosis and muscle fibrosis. Glycogen deposition in many skeletal muscles; the tongue, diaphragm, and heart; and the phrenic and sciatic nerves occurred also. Furthermore, the urinary biomarker Glc4, which has been described in many types of GSD, was first elevated and then decreased later in life. This urinary biomarker demonstrated a similar trend as AST and ALT in GSD IIIa dogs, indicating that Glc4 might be a less invasive biomarker of hepatocellular disease. Finally, the current study further demonstrates that the canine GSD IIIa model adheres to the clinical course in human patients with this disorder and is an appropriate model for developing novel therapies.

  10. The role of geodata and geotools in sustainable energy planning. The Interreg project 'North Sea Sustainable Energy Planning'; Die Bedeutung von Geodaten und Geowerkzeugen fuer eine nachhaltige Energieplanung. Das Interreg-Projekt 'North Sea Sustainable Energy Planning'

    Energy Technology Data Exchange (ETDEWEB)

    Knies, Juergen [Jade Hochschule Wilhelmshaven/Oldenburg/Elsfleth, Oldenburg (DE). Inst. fuer Angewandte Photogrammetrie und Geoinformatik (IAPG)

    2012-07-01

    The Interreg IVB project 'North Sea Sustainable Energy Planning' is to promote the development of models for regional development in consideration of renewable energy sources and the implementation of measures for higher energy efficiency in consideration of regional and international boundary conditions. Geodata and geotools provide a basis for sustainable energy planning. The Institute of Applied Photogrammetry and Geoinformatics of Jade Hochschule University developed concepts and geotools to support decision-makers in this task. The concepts and tools are presented in this paper.

  11. Distribution of Heparan Sulfate Oligosaccharides in Murine Mucopolysaccharidosis Type IIIA

    Directory of Open Access Journals (Sweden)

    Kerryn Mason

    2014-12-01

    Full Text Available Heparan sulfate (HS catabolism begins with endo-degradation of the polysaccharide to smaller HS oligosaccharides, followed by the sequential action of exo-enzymes to reduce these oligosaccharides to monosaccharides and inorganic sulfate. In mucopolysaccharidosis type IIIA (MPS IIIA the exo-enzyme, N-sulfoglucosamine sulfohydrolase, is deficient resulting in an inability to hydrolyze non-reducing end glucosamine N-sulfate esters. Consequently, partially degraded HS oligosaccharides with non-reducing end glucosamine sulfate esters accumulate. We investigated the distribution of these HS oligosaccharides in tissues of a mouse model of MPS IIIA using high performance liquid chromatography electrospray ionization-tandem mass spectrometry. Oligosaccharide levels were compared to total uronic acid (UA, which was used as a measure of total glycosaminoglycan. Ten oligosaccharides, ranging in size from di- to hexasaccharides, were present in all the tissues examined including brain, spleen, lung, heart, liver, kidney and urine. However, the relative levels varied up to 10-fold, suggesting different levels of HS turnover and storage. The relationship between the di- and tetrasaccharides and total UA was tissue specific with spleen and kidney showing a different disaccharide:total UA ratio than the other tissues. The hexasaccharides showed a stronger correlation with total UA in all tissue types suggesting that hexasaccharides may more accurately reflect the storage burden in these tissues.

  12. BLM and RMI1 Alleviate RPA Inhibition of TopoIIIa Decatenase Activity

    DEFF Research Database (Denmark)

    Yang, Jay; Bachrati, Csanad Z; Hickson, Ian D

    2012-01-01

    RPA is a single-stranded DNA binding protein that physically associates with the BLM complex. RPA stimulates BLM helicase activity as well as the double Holliday junction dissolution activity of the BLM-topoisomerase IIIa complex. We investigated the effect of RPA on the ssDNA decatenase activity......-specific interactions between RPA and BLM-TopoIIIa-RMI1, which contrasts with RPA modulation of double Holliday junction dissolution. We propose that topoisomerase IIIa and RPA compete to bind to single-stranded regions of catenanes. Interactions with BLM and RMI1 enhance toposiomerase IIIa activity, promoting...

  13. 75 FR 75682 - Reclassification of Category IIIA Biological Products, Bacterial Vaccines and Related Biological...

    Science.gov (United States)

    2010-12-06

    ... Category IIIA, that FDA had proposed to place into Category IIIA, or for which FDA had issued a final order..., Docket No. 2000N-1219, as attachments to Delmont's April 28, 2003, hearing request. None of the data... Inoculation with Herpes Simplex Virus'' (Department of Microbiology, School of Medicine, Kyushu University...

  14. Paul Scherrer Institut annual report 1994. Annex IIIA: PSI condensed matter research and material sciences

    Energy Technology Data Exchange (ETDEWEB)

    Baltensperger, U. [ed.] [Paul Scherrer Inst. (PSI), Villigen (Switzerland)

    1995-10-01

    This annex reports on the PSI division IIIA`s progress achieved during 1994 in the Laboratory of Ionbeam-Physics, the Laboratory of Radiochemistry; the Laboratory for Neutron Scattering and the Laboratory for Astrophysics. Progress of the spallation neutron source project (SINQ) is documented by a set of pictures. A bibliography of the department`s publications is included. figs., tabs., refs.

  15. Outcome of endometrial cancer stage IIIA with adnexa or serosal involvement only

    NARCIS (Netherlands)

    Jobsen, Jan J.; Naudin ten Cate, Lambert; Lybeert, Marnix L.M.; Scholten, Astrid; van der Steen-Banasik, Elzbieta M.; van der Palen, Jacobus Adrianus Maria; Stenfert Kroese, Marika C.; Slot, Annerie; Schutter, Eltjo M.; Siesling, Sabine

    2011-01-01

    Objective. The aim of this study is to look at possible differences in outcome between serosa and adnexal involvement stage IIIA endometrial carcinoma. Methods. 67 patients with stage IIIA endometrial carcinoma were included, 46 with adnexal involvement and 21 with serosa. A central

  16. A Silicate Inclusion in Puente del Zacate, a IIIA Iron Meteorite

    Science.gov (United States)

    Olsen, Edward J.; Davis, Andrew M.; Clayton, Robert N.; Mayeda, Toshiko K.; Moore, Carleton B.; Steele, Ian M.

    1996-09-01

    The IIIA and IIIB iron meteorites are considered to have formed in the cores of asteroids. A silicate inclusion within the IIIA meteorite Puente del Zacate consisting of olivine (Fa_4), low-calcium pyroxene (Fs_6Wo_1), chromium diopside (Fs_3Wo47), plagioclase (An14Or_4), graphite, troilite, chromite, daubreelite, and iron metal resembles inclusions in IAB iron meteorites. The oxygen isotopic composition of the Puente del Zacate inclusion is like chromite and phosphate inclusions in other IIIA and IIIB irons. The Puente del Zacate inclusion may have been derived from the lower mantle of the IIIAB parent asteroid.

  17. Medical-Nutritional Intervention in a Jordanian Child with Glycogen Storage Disease Type IIIA: Case Report

    Directory of Open Access Journals (Sweden)

    Al-Zeidaneen Safaa A.

    2017-12-01

    Full Text Available Background: Glycogen storage disease (GSD type IIIa is a rare inborn error of metabolism characterized by a deficiency in glycogen disbranching enzymes. Nutritional intervention is a cornerstone in the medical care plane.

  18. Inherent lipid metabolic dysfunction in glycogen storage disease IIIa.

    Science.gov (United States)

    Li, Xin-Hua; Gong, Qi-Ming; Ling, Yun; Huang, Chong; Yu, De-Min; Gu, Lei-Lei; Liao, Xiang-Wei; Zhang, Dong-Hua; Hu, Xi-Qi; Han, Yue; Kong, Xiao-Fei; Zhang, Xin-Xin

    2014-12-05

    We studied two patients from a nonconsanguineous family with life-long abnormal liver function, hepatomegaly and abnormal fatty acid profiles. Abnormal liver function, hypoglycemia and muscle weakness are observed in various genetic diseases, including medium-chain acyl-CoA dehydrogenase (MCAD) deficiency and glycogen storage diseases. The proband showed increased free fatty acids, mainly C8 and C10, resembling fatty acid oxidation disorder. However, no mutation was found in ACADM and ACADL gene. Sequencing of theamylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase (AGL) gene showed that both patients were compound heterozygotes for c.118C > T (p.Gln40X) and c.753_756 del CAGA (p.Asp251Glufsx29), whereas their parents were each heterozygous for one of these mutations. The AGL protein was undetectable in EBV-B cells from the two patients. Transcriptome analysis demonstrated a significant different pattern of gene expression in both of patients’ cells, including genes involving in the PPAR signaling pathway, fatty acid biosynthesis, lipid synthesis and visceral fat deposition and metabolic syndrome. This unique gene expression pattern is probably due to the absence of AGL, which potentially accounts for the observed clinical phenotypes of hyperlipidemia and hepatocyte steatosis in glycogen storage disease type IIIa.

  19. Far-infrared fusion plasma diagnostics. Task IIIA. Final report

    International Nuclear Information System (INIS)

    Luhmann, N.C. Jr.

    1986-01-01

    The Task IIIA program at UCLA has been concerned with the development of innovative yet practical plasma diagnostic systems capable of providing detailed information essential to the success of the fusion program but not presently available within the fusion community. Historically, this has involved an initial development in the laboratory, followed by a test of feasibility on the Microtor tokamak prior to transfer of the technique/instrument to main line fusion devices. Strong emphasis has been placed upon the far-infrared (FIR) spectral region where novel diagnostic systems and technology have been developed and then distributed throughout the fusion program. The major diagnostics under development have been the measurement of plasma microturbulence and coherent modes via multichannel cw collective Thomson scattering, and the application of phase/polarization imaging techniques to provide accurate and detailed (>20 channel) electron density and current profiles not presently available using conventional methods. The eventual transfer of the above techniques to main line fusion devices is, of course, a major goal of the UCLA development program. The multichannel scattering development at UCLA was efficiently transferred to TEXT a few years ago. The apparatus has been employed to investigate the strong spectral and spatial asymmetries in the microturbulence uncovered through the unique multichannel and spatial scanning capabilities of the system. The scattering apparatus has also produced evidence for the ion pressure gradient driven eta/sub i/ modes thought responsible for anomalous transport in the edge regions of tokamak plasmas, as well as providing insight into the wave-wave coupling processes between various plasma modes

  20. Enzyme-replacement therapy from birth delays the development of behavior and learning problems in mucopolysaccharidosis type IIIA mice.

    Science.gov (United States)

    Gliddon, Briony L; Hopwood, John J

    2004-07-01

    Mucopolysaccharidosis type IIIA (MPS IIIA; Sanfilippo syndrome) is a lysosomal storage disorder characterized by severe CNS degeneration, resulting in behavioral abnormalities and loss of learned abilities. Early treatment is vital to prevent long-term clinical pathology in lysosomal storage disorders. We have used naturally occurring MPS IIIA mice to assess the effects of long-term enzyme-replacement therapy initiated either at birth or at 6 wk of age. MPS IIIA and normal control mice received weekly i.v. injections of 1 mg/kg recombinant human sulfamidase until 20 wk of age. Sulfamidase is able to enter the brain until the blood-brain barrier completely closes at 10-14 d of age. MPS IIIA mice that were treated from birth demonstrated normal weight, behavioral characteristics, and ability to learn. MPS IIIA mice that were treated from birth performed significantly better in the Morris water maze than MPS IIIA mice that were treated from 6 wk of age or left untreated. A reduction in storage vacuoles in cells of the CNS in MPS IIIA mice that were treated from birth is consistent with the improvements observed. These data suggest that enzyme that enters the brain in the first few weeks of life, before the blood-brain barrier matures, is able to delay the development of behavior and learning difficulties in MPS IIIA mice.

  1. Elucidation of the mechanisms of CryIIIA overproduction in a mutagenized strain of Bacillus thuringiensis var. tenebrionis

    International Nuclear Information System (INIS)

    Adams, L.F.; Mathewes, S.; O'Hara, P.; Peterson, A.; Gürtler, H.

    1994-01-01

    NB176 is a Bacillus thuringiensis mutant derived by λ-irradiation of NB125 Bacillus thuringiensis var. tenebrionis (Krieg). It exhibits two interesting phenotypes: (i) oligosporogeny and (ii) twofold to threefold overproduction of the CryIIIA protein. Southern profiles of the NB176 strain showed an additional copy(s) of the cryIIIA gene located on a 4 kb HindIII fragment, in addition to the expected cryIIIA gene on a 3 kb HindIII fragment. Each cryIIIA gene-bearing HindIII fragment was cloned from NB176. The restriction map of the 3 kb HindIII fragment was identical to that published by Donovan and coworkers. Sequencing of the 4 kb HindIII fragment showed no alterations in the promoter region of the cryIIIA gene but did show replacement of the region immediately following the cryIIIA open reading frame with a sequence encoding a transposase with 50% amino acid homology to that of Tn 1000. These findings suggest that the overproduction phenotype of NB176 results from extra copies of the cryIIIA gene produced from a transposition event(s) induced or stabilized by γ-irradiation. Integration of additional copies of the cryIIIA gene into the native 90MDa plasmid of the wild-type B. thuringiensis var. tenebrionis strain resulted in strains that made enormous crystals, many possessing greatly enhanced insecticidal activity

  2. The number of metastatic sites for stage IIIA endometrial carcinoma, endometrioid cell type, is a strong negative prognostic factor

    NARCIS (Netherlands)

    Jobsen, Jan J.; Naudin ten Cate, Lambert; Lybeert, Marnix L.M.; van der Steen-Banasik, Elzbieta M.; Scholten, A.M.; van der Palen, Jacobus Adrianus Maria; van der Palen, J.; Slot, Annerie; Stenfert Kroese, Marika C.; Schutter, Eltjo M.; Siesling, Sabine

    2010-01-01

    The aim of this study was to look at the impact of the number of sites with tumour involvement on outcome for patients with stage IIIA endometrioid-type endometrial carcinoma. Patients and methods: 141 patients stage IIIA were included. A central histopathological review was performed. Patients

  3. Arteriosclerosis and the promise of GPIIb/IIIa inhibitors in stroke Arteriosclerosis y nuevas perspectivas de los inhibidores del receptor GPIIb/IIIa en stroke

    Directory of Open Access Journals (Sweden)

    GUSTAVO SAPOSNIK

    2000-03-01

    Full Text Available Ischemic mechanisms in patients with brain and heart attacks have been studied for more than 150 years. Antiplatelets agents did show benefit in secondary prevention. Aspirin is the most common antiaggregant in clinical use today. However, the benefit produced by the "best" antiplatelet regimen in stroke prevention is lower than 40%. The adherence of circulating platelets to the subendothelium is mediated by glycoprotein (GP residing on the cell's surface. GPIIb/IIIa is the most important platelet membrane receptor that mediates the process of platelet aggregation, and thrombus formation. Thus, new drugs that block the GPIIb/IIIa receptor have recently emerged. Clinical trials using these agents have shown effectiveness in acute coronary syndromes. However, the absence of studies in cerebrovascular disease and the potential hemorrhagic complications questioned their use in stroke prevention. We review the clinical trials using the new GPIIb/IIIa agents in myocardial ischemia, and consider the potential implications for cerebrovascular disease.Los mecanismos de isquemia en infarto de miocardio y enfermedad cerebrovascular (ECV han sido estudiados por mas de 150 años. Drogas antiplaquetarias mostraron un beneficio en la prevención secundaria. La aspirina es el mas común de los antiagregantes usados en la practica clínica. No obstante, el beneficio producido, aun con el "mejor" tratamiento antiagregante, en la prevención de ECV es inferior al 40%. La adhesión plaquetaria es un proceso mediado por glicoproteinas (GP de la membrana celular. GPIIb/IIIa es un receptor de membrana plaquetaria que interviene en el proceso de agregación plaquetaria y formación del trombo. Estudios clínicos con nuevos agentes que bloquean a este receptor mostraron ser efectivos en los síndromes coronarios agudos. No obstante, la falta de estudios en ECV y las potenciales complicaciones hemorrágicas, limitan su uso en la prevención de stroke. Revisamos los

  4. Production and characterization of monoclonal antibodies against rat platelet GPIIb/IIIa

    International Nuclear Information System (INIS)

    Miyazaki, H.; Tamura, S.; Sudo, T.; Suzuki, T.

    1990-01-01

    Four murine monoclonal antibodies against rat platelets were produced by fusion of spleen cells from mice intravenously immunized with whole rat platelets. All four antibodies immunoprecipitated two major platelet membrane proteins with apparent molecular weights of 130,000 and 82,000 (nonreduced) and of 120,000 and 98,000 (reduced), which were structurally analogous to human glycoprotein (GP) IIb/IIIa, i.e. rat GPIIb/IIIa. Two of four antibodies, named P9 and P55, strongly inhibited adenosine diphosphate (ADP)-induced aggregation of washed rat platelets and caused approximately 50% inhibition of human fibrinogen binding to ADP-stimulated rat platelets, suggesting that rat GPIIb/IIIa serves as a fibrinogen receptor in ADP-induced aggregation. In contrast, two other antibodies, named P14 and P34, themselves caused aggregation of rat platelets in platelet-rich plasma (PRP) and the secretion of 14C-serotonin from 14C-serotonin-labeled PRP. These results indicate that rat GPIIb/IIIa plays an important role in platelet aggregation

  5. 77 FR 9163 - Removal of Category IIIa, IIIb, and IIIc Definitions

    Science.gov (United States)

    2012-02-16

    ... Passive control system concepts.\\2\\ The first U.S. aircraft certification for CAT IIIa occurred in 1971... international harmonization efforts, future landing minima reductions, and airspace system capacity improvements... Department of Transportation (DOT) (44 FR 1134) provide that to the maximum extent possible, operating...

  6. Paul Scherrer Institut annual report 1994. Annex IIIA: PSI condensed matter research and material sciences

    International Nuclear Information System (INIS)

    Baltensperger, U.

    1995-01-01

    This annex reports on the PSI division IIIA's progress achieved during 1994 in the Laboratory of Ionbeam-Physics, the Laboratory of Radiochemistry; the Laboratory for Neutron Scattering and the Laboratory for Astrophysics. Progress of the spallation neutron source project (SINQ) is documented by a set of pictures. A bibliography of the department's publications is included. figs., tabs., refs

  7. Contribution of inhibitory receptor glycoprotein iib / iiia in coronary angioplasty and acute coronary syndrome, about 152 patients

    International Nuclear Information System (INIS)

    Sellami, Walid

    2007-01-01

    The aim of our study was to evaluate the immediate results and long-term intake of anti-GP IIb / IIIa inhibitors for patients with acute coronary syndrome treated with coronary angioplasty. The use of anti-GP IIb / IIIa is a valid therapeutic option in patients with acute coronary syndrome with signs of severity and for patients undergoing complex angioplasty. Adverse effects of anti-GP IIb / IIIa can be seen to encourage vigilance and careful monitoring during the administration of these molecules and perfect knowledge of their pharmacological properties for appropriate use.

  8. Risk-stratifying capacity of PET/CT metabolic tumor volume in stage IIIA non-small cell lung cancer

    Energy Technology Data Exchange (ETDEWEB)

    Finkle, Joshua H.; Jo, Stephanie Y.; Yuan, Cindy; Pu, Yonglin [University of Chicago, Department of Radiology, Chicago, IL (United States); Ferguson, Mark K. [University of Chicago, Department of Surgery, Chicago, IL (United States); Liu, Hai-Yan [First Hospital of Shanxi Medical University, Department of Nuclear Medicine, Taiyuan, Shanxi (China); Zhang, Chenpeng [Shanghai Jiao Tong University, Department of Nuclear Medicine, RenJi Hospital, School of Medicine, Shanghai (China); Zhu, Xuee [Nanjing Medical University, Department of Radiology, BenQ Medical Center, Nanjing, Jiangsu Province (China)

    2017-08-15

    Stage IIIA non-small cell lung cancer (NSCLC) is heterogeneous in tumor burden, and its treatment is variable. Whole-body metabolic tumor volume (MTV{sub WB}) has been shown to be an independent prognostic index for overall survival (OS). However, the potential of MTV{sub WB} to risk-stratify stage IIIA NSCLC has previously been unknown. If we can identify subgroups within the stage exhibiting significant OS differences using MTV{sub WB}, MTV{sub WB} may lead to adjustments in patients' risk profile evaluations and may, therefore, influence clinical decision making regarding treatment. We estimated the risk-stratifying capacity of MTV{sub WB} in stage IIIA by comparing OS of stratified stage IIIA with stage IIB and IIIB NSCLC. We performed a retrospective review of 330 patients with clinical stage IIB, IIIA, and IIIB NSCLC diagnosed between 2004 and 2014. The patients' clinical TNM stage, initial MTV{sub WB}, and long-term survival data were collected. Patients with TNM stage IIIA disease were stratified by MTV{sub WB}. The optimal MTV{sub WB} cutoff value for stage IIIA patients was calculated using sequential log-rank tests. Univariate and multivariate cox regression analyses and Kaplan-Meier OS analysis with log-rank tests were performed. The optimal MTV{sub WB} cut-point was 29.2 mL for the risk-stratification of stage IIIA. We identified statistically significant differences in OS between stage IIB and IIIA patients (p < 0.01), between IIIA and IIIB patients (p < 0.01), and between the stage IIIA patients with low MTV{sub WB} (below 29.2 mL) and the stage IIIA patients with high MTV{sub WB} (above 29.2 mL) (p < 0.01). There was no OS difference between the low MTV{sub WB} stage IIIA and the cohort of stage IIB patients (p = 0.485), or between the high MTV{sub WB} stage IIIA patients and the cohort of stage IIIB patients (p = 0.459). Similar risk-stratification capacity of MTV{sub WB} was observed in a large range of cutoff values from 15 to 55 mL in

  9. Outcome of Endometrial Cancer Stage IIIA with Adnexa or Serosal Involvement Only

    Directory of Open Access Journals (Sweden)

    Jan J. Jobsen

    2011-01-01

    Methods. 67 patients with stage IIIA endometrial carcinoma were included, 46 with adnexal involvement and 21 with serosa. A central histopathological review was performed. Results. The 7-year locoregional failure rate was (LRFR 2.2% for adnexal involvement and 16.0% for involvement of the serosa (P=.0522. The 7-year distant metastasis-free survival was 72.7% for adnexal involvement and 58.7% for serosa (P=.3994. The 7-year disease-specific survival (DSS was 71.8% for patients with adnexal involvement and 75.4% for patients with serosa. Conclusion. Endometrial carcinoma stage IIIA with involvement of the adnexa or serosa showed to have a comparable disease-specific survival. Locoregional control was worse for serosa involvement compared to adnexa.

  10. Hypofractionated Radiation Therapy After Mastectomy in Preventing Recurrence in Patients With Stage IIa-IIIa Breast Cancer

    Science.gov (United States)

    2018-04-06

    Ductal Breast Carcinoma; Invasive Breast Carcinoma; Lobular Breast Carcinoma; Medullary Breast Carcinoma; Stage II Breast Cancer; Stage IIA Breast Cancer; Stage IIB Breast Cancer; Stage IIIA Breast Cancer; Tubular Breast Carcinoma

  11. Type IIIa cracking at 2CrMo welds in 1/2CrMoV pipework

    Energy Technology Data Exchange (ETDEWEB)

    Brett, S.J.; Smith, P.A. [National Power plc, Swindon (United Kingdom)

    1998-12-31

    The most common form of in-service defect found today on the welds of National Power`s 1/2CrMoV pipework systems is Type IV cracking which occurs in intercritically transformed material at the edge of the heat affected zone. However an alternate form of cracking, termed IIIa, which occurs close to the weld fusion line in fully grain refined heat affected zones, has also been observed. The incidence of Type IIIa cracking has increased in recent years and these defects now constitute a significant part of the total recorded crack population. This presentation describes Type IIIa cracking and compares and contrasts it with the better documented Type IV cracking. Particular reference is made to the role of carbon diffusion at the weld fusion line in promoting Type IIIa damage in preference to Type IV. (orig.) 5 refs.

  12. Adenovirus structural protein IIIa is involved in the serotype specificity of viral DNA packaging.

    Science.gov (United States)

    Ma, Hsin-Chieh; Hearing, Patrick

    2011-08-01

    The packaging of the adenovirus (Ad) genome into a capsid displays serotype specificity. This specificity has been attributed to viral packaging proteins, the IVa2 protein and the L1-52/55K protein. We previously found that the Ad17 L1-52/55K protein was not able to complement the growth of an Ad5 L1-52/55K mutant virus, whereas two other Ad17 packaging proteins, IVa2 and L4-22K, could complement the growth of Ad5 viruses with mutations in the respective genes. In this report, we investigated why the Ad17 L1-52/55K protein was not able to complement the Ad5 L1-52/55K mutant virus. We demonstrate that the Ad17 L1-52/55K protein binds to the Ad5 IVa2 protein in vitro and the Ad5 packaging domain in vivo, activities previously associated with packaging function. The Ad17 L1-52/55K protein also associates with empty Ad5 capsids. Interestingly, we find that the Ad17 L1-52/55K protein is able to complement the growth of an Ad5 L1-52/55K mutant virus in conjunction with the Ad17 structural protein IIIa. The same result was found with the L1-52/55K and IIIa proteins of several other Ad serotypes, including Ad3 and Ad4. The Ad17 IIIa protein associates with empty Ad5 capsids. Consistent with the complementation results, we find that the IIIa protein interacts with the L1-52/55K protein in vitro and associates with the viral packaging domain in vivo. These results underscore the complex nature of virus assembly and genome encapsidation and provide a new model for how the viral genome may tether to the empty capsid during the encapsidation process.

  13. Treatment outcomes in stage IIIA non-small-cell lung cancer in a community cancer center.

    Science.gov (United States)

    Hanson, Shaun; Persad, Kamleish; Qiao, Xian; Guarino, Michael; Petrelli, Nicholas

    2015-08-01

    Treatment outcomes for non-small-cell lung cancer (NSCLC) patients diagnosed at stage IIIA have been analyzed in many studies, which generally involve patients younger and healthier than the average patient with this disease. To analyze demographics and treatment outcomes in patients with stage IIIA NSCLC at a community cancer center. We reviewed charts of 226 patients diagnosed with stage IIIA NSCLC from January 2003 to December 2008 treated at our community cancer center. Results Median overall survival for all patients and sequentially and concurrently treated chemoradiation patients were 18 months, and 18 months, and 20 months, respectively. Median overall survival for women and men was 24 months and 16 months, respectively. Median overall survival for all patients and sequentially and concurrently treated chemoradiation patients were 18 months, and 18 months, and 20 months, respectively. Median overall survival for women and men was 24 months and 16 months, respectively. Study design was retrospective and some medical records were not available. However, this population is likely representative of patients treated in similar settings. In our population, advanced age and male gender were associated with lower median survival. Responses to concurrent and sequential chemoradiation seemed to differ based on age group, which may be useful as a prognostic guideline for similar populations. ©2015 Frontline Medical Communications.

  14. Survival Advantage Associated with Decrease in Stage at Detection from Stage IIIC to Stage IIIA Epithelial Ovarian Cancer

    Science.gov (United States)

    Lefringhouse, Jason; Pavlik, Edward; Miller, Rachel; DeSimone, Christopher; Ueland, Frederick; Kryscio, Richard; van Nagell, J. R.

    2014-01-01

    Objective. The aim of this study was to document the survival advantage of lowering stage at detection from Stage IIIC to Stage IIIA epithelial ovarian cancer. Methods. Treatment outcomes and survival were evaluated in patients with Stage IIIA and Stage IIIC epithelial ovarian cancer treated from 2000 to 2009 at the University of Kentucky Markey Cancer Center (UKMCC) and SEER institutions. Results. Cytoreduction to no visible disease (P < 0.0001) and complete response to platinum-based chemotherapy (P < 0.025) occurred more frequently in Stage IIIA than in Stage IIIC cases. Time to progression was shorter in patients with Stage IIIC ovarian cancer (17 ± 1 months) than in those with Stage II1A disease (36 ± 8 months). Five-year overall survival (OS) improved from 41% in Stage IIIC patients to 60% in Stage IIIA patients treated at UKMCC and from 37% to 56% in patients treated at SEER institutions for a survival advantage of 19% in both data sets. 53% of Stage IIIA and 14% of Stage IIIC patients had NED at last followup. Conclusions. Decreasing stage at detection from Stage IIIC to stage IIIA epithelial ovarian cancer is associated with a 5-year survival advantage of nearly 20% in patients treated by surgical tumor cytoreduction and platinum-based chemotherapy. PMID:25254047

  15. Chondrite chronology by initial Sr-87/Sr-86 in phosphates?

    Science.gov (United States)

    Podosek, Frank A.; Brannon, Joyce C.

    1991-01-01

    New data are presented on Rb-Sr isotope analyses of phosphates from nine ordinary chondrites, including accurate identification of initial Sr-87/Sr-86. The initial Sr-87/Sr-86 ratios found in this study were generally significantly higher than the more primitive initial Sr-87/Sr-86 ratios inferred for carbonaceous chondrite refractory inclusions, basaltic achondrites, or bulk ordinary chondrites. Such elevation of initial Sr-87/Sr-86 is generally considered to reflect isotopic redistribution during metamorphism. However, in this study, no evident correlation was found between the phosphate initial Sr-87/Sr-86 compositions and the metamorphic grade. Two possible alternative hypotheses for high initial Sr-87/Sr-86 ratios are considered.

  16. Prognostic value of immunohistochemical marker HER2/neu in patients resected for gastric cancer stage IIIA

    Directory of Open Access Journals (Sweden)

    O. M. Levyk

    2014-04-01

    Full Text Available Introduction Patients with the same stage of malignancy often have different life-span, which makes it necessary to search for new prognostic factors. The high incidence and low survival rate of patients with gastric cancer also cause an increased interest in studying the immunohistochemical profile of tumors of the stomach. Recently, researchers are studying the prognostic significance of immunohistochemical markers such as: EGFR [10], VEGF [12,15,18], HER2/neu [8,17,19], expression of betakatenin [1], hERG1 [7], p53 [14], PCNA [14,20] Of particular interest is the HER2/neu. Overexpression of HER2/neu promotes tumor growth and plays an important role in the pathogenesis of some human malignancies [17].Nevertheless, the impact of HER2/neu status on the prognosis of patients with gastric cancer remains controversial [6,11,19]. Nakajima Garcia and colleagues believe that the increased expression of HER2/neu in patients with gastric cancer correlates with poor prognosis and more aggressive disease [11]. At the same time, Begnami found that life expectancy in gastric cancer patients with HER-2/neu-positively stained tumors was significantly shorter than in patients with HER-2/neu-negatively stained tumors (17 months vs. 40 months, respectively, p=0.023 [5]. The aim of research Study the prognostic significance of immunohistochemical marker HER-2/neu in patients resected for gastric cancer stage IIIA. Materials and methods Materials for the study were histologic surgical specimens of the primary tumor in 21 patients who had surgery in the Zaporozhye Regional Clinical Oncology Center due to stomach cancer stage IIIA, including 14 men (67% and 7 females (33%. Patients underwent surgery in the volume: gastrectomy and distal subtotal resection, 86% of patients received adjuvant chemotherapy of standard schemes. Immunohistochemical study of HER2/neu (erbB-2 used a rabbit polyclonal antibody. Immunohistochemical reaction was evaluated as negative in the

  17. Characterization of a canine model of glycogen storage disease type IIIa

    Directory of Open Access Journals (Sweden)

    Haiqing Yi

    2012-11-01

    Glycogen storage disease type IIIa (GSD IIIa is an autosomal recessive disease caused by deficiency of glycogen debranching enzyme (GDE in liver and muscle. The disorder is clinically heterogeneous and progressive, and there is no effective treatment. Previously, a naturally occurring dog model for this condition was identified in curly-coated retrievers (CCR. The affected dogs carry a frame-shift mutation in the GDE gene and have no detectable GDE activity in liver and muscle. We characterized in detail the disease expression and progression in eight dogs from age 2 to 16 months. Monthly blood biochemistry revealed elevated and gradually increasing serum alanine transaminase (ALT, aspartate transaminase (AST and alkaline phosphatase (ALP activities; serum creatine phosphokinase (CPK activity exceeded normal range after 12 months. Analysis of tissue biopsy specimens at 4, 12 and 16 months revealed abnormally high glycogen contents in liver and muscle of all dogs. Fasting liver glycogen content increased from 4 months to 12 months, but dropped at 16 months possibly caused by extended fibrosis; muscle glycogen content continually increased with age. Light microscopy revealed significant glycogen accumulation in hepatocytes at all ages. Liver histology showed progressive, age-related fibrosis. In muscle, scattered cytoplasmic glycogen deposits were present in most cells at 4 months, but large, lake-like accumulation developed by 12 and 16 months. Disruption of the contractile apparatus and fraying of myofibrils was observed in muscle at 12 and 16 months by electron microscopy. In conclusion, the CCR dogs are an accurate model of GSD IIIa that will improve our understanding of the disease progression and allow opportunities to investigate treatment interventions.

  18. Structure of sulfamidase provides insight into the molecular pathology of mucopolysaccharidosis IIIA

    Energy Technology Data Exchange (ETDEWEB)

    Sidhu, Navdeep S. [University of Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen (Germany); University of Göttingen, Tammannstrasse 4, 37077 Göttingen (Germany); Schreiber, Kathrin [University of Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen (Germany); Pröpper, Kevin [University of Göttingen, Tammannstrasse 4, 37077 Göttingen (Germany); Becker, Stefan [Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen (Germany); Usón, Isabel [Instituto de Biologia Molecular de Barcelona (IBMB–CSIC), Barcelona Science Park, Baldiri Reixach 15, 08028 Barcelona (Spain); Institucio Catalana de Recerca i Estudis Avancats (ICREA), (Spain); Sheldrick, George M. [University of Göttingen, Tammannstrasse 4, 37077 Göttingen (Germany); Gärtner, Jutta; Krätzner, Ralph, E-mail: rkraetz@gwdg.de; Steinfeld, Robert, E-mail: rkraetz@gwdg.de [University of Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen (Germany)

    2014-05-01

    Mucopolysaccharidosis IIIA is a fatal neurodegenerative disease that typically manifests itself in childhood and is caused by mutations in the gene for the lysosomal enzyme sulfamidase. The first structure of this enzyme is presented, which provides insight into the molecular basis of disease-causing mutations, and the enzymatic mechanism is proposed. Mucopolysaccharidosis type IIIA (Sanfilippo A syndrome), a fatal childhood-onset neurodegenerative disease with mild facial, visceral and skeletal abnormalities, is caused by an inherited deficiency of the enzyme N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase). More than 100 mutations in the SGSH gene have been found to reduce or eliminate its enzymatic activity. However, the molecular understanding of the effect of these mutations has been confined by a lack of structural data for this enzyme. Here, the crystal structure of glycosylated SGSH is presented at 2 Å resolution. Despite the low sequence identity between this unique N-sulfatase and the group of O-sulfatases, they share a similar overall fold and active-site architecture, including a catalytic formylglycine, a divalent metal-binding site and a sulfate-binding site. However, a highly conserved lysine in O-sulfatases is replaced in SGSH by an arginine (Arg282) that is positioned to bind the N-linked sulfate substrate. The structure also provides insight into the diverse effects of pathogenic mutations on SGSH function in mucopolysaccharidosis type IIIA and convincing evidence for the molecular consequences of many missense mutations. Further, the molecular characterization of SGSH mutations will lay the groundwork for the development of structure-based drug design for this devastating neurodegenerative disorder.

  19. Environmental 90Sr measurements

    Science.gov (United States)

    Paul, M.; Berkovits, D.; Cecil, L.D.; Feldstein, H.; Hershkowitz, A.; Kashiv, Y.; Vogt, S.

    1997-01-01

    90Sr (T1/2 = 28.5 years) is a long-lived radionuclide produced in nuclear fission. Fast radiochemical detection of 90Sr in environmental samples is not feasible using current analytical methods. Accelerator Mass Spectrometry (AMS) measurements of 90Sr were made with the Rehovot 14UD Pelletron accelerator at a terminal voltage of 11 or 12 MV using our standard detection system. Injection of hydride ions (SrH3-) was chosen owing to high beam intensity and low Coulomb explosion effects. 90Sr ions were identified and discriminated from isobaric 90Zr by measuring time of flight, total energy and three independent energy-loss signals in an ionization chamber. A reference sample and a ground-water sample were successfully measured. The detection limit determined for a laboratory blank by the residual counts in the 90Sr region is 90Sr/Sr = 3 ?? 10-13, corresponding in practice to (2-4) ?? 10790Sr atoms or about 0.5-1 pCi/L in environmental water samples.

  20. Design of potent and specific integrin antagonists. Peptide antagonists with high specificity for glycoprotein IIb-IIIa.

    Science.gov (United States)

    Scarborough, R M; Naughton, M A; Teng, W; Rose, J W; Phillips, D R; Nannizzi, L; Arfsten, A; Campbell, A M; Charo, I F

    1993-01-15

    Members of the snake venon-derived, "disintegrin" peptide family containing the Arg-Gly-Asp (RGD) amino acid sequence are among the most potent inhibitors of the binding of adhesive proteins to platelet glycoprotein (GP) IIb-IIIa. However, GPIIb-IIIa antagonists containing the RGD sequence are not integrin specific and inhibit the adhesive functions of many other RGD-dependent integrins. The single disintegrin peptide, barbourin, containing a conservative amino acid substitution of Lys (K) for Arg (R) in the RGD sequence, is however, highly specific for GPIIb-IIIa. Using this information we have tested the hypothesis that both structural and conformational elements of barbourin are important for its high affinity and selectivity for platelet GPIIb-IIIa by synthesizing a series of conformationally constrained, disulfide-bridged peptides containing the KGD amino acid sequence. Incorporation of the KGD sequence into a cyclic peptide template, followed by systematic optimization of the cyclic ring size, optimization of secondary hydrophobic binding site interactions, and the derivatization of the lysyl side chain functionality of the KGD sequence has resulted in peptide analogs which display inhibitory potency and GPIIb-IIIa selectivity comparable to that of barbourin. This study demonstrates that the specificity and potency of the disintegrin family of antagonists, in particular barbourin, can be mimicked by small, conformationally restrained peptides.

  1. An effect of glycoprotein IIb/IIIa inhibitors on the kinetics of red blood cells aggregation.

    Science.gov (United States)

    Sokolova, Irina A; Muravyov, Alexei V; Khokhlova, Maria D; Rikova, Sofya Yu; Lyubin, Evgeny V; Gafarova, Marina A; Skryabina, Maria N; Fedyanin, Angrey A; Kryukova, Darya V; Shahnazarov, Alexander A

    2014-01-01

    The reversible aggregation of red blood cells (RBCs) continues to be of the basic science and clinical interest. Recently it has been reported about a specific binding between fibrinogen and unknown erythrocyte glycoprotein receptors. The aim of this study was to investigate whether the red blood cell aggregation (RBCA) include the cell-cell interaction using the membrane receptors that bind such ligands as fibrinogen or fibronectin. To test this hypothesis the RBCs were incubated with monafram - the drug of the monoclonal antibodies against glycoprotein (GP) IIb/IIIa, with the GPIIb-IIIa receptor antagonist tirofiban, epifibatide and with the fibrinogen inhibiting peptide. It has been found that the RBC incubation with monafram resulted in a marked RBCA decrease mainly in persons with high level of aggregation. Another research session has shown that RBC incubation with fibronectin was accompanied by a significant RBCA rise. The monafram addition to red cell incubation medium resulted in a significant RBCA lowering. The cell incubation with tirofiban and epifibatide issued in RBCA decrease. The similar results were obtained when RBCs were incubated with the fibrinogen inhibiting peptide. Although monafram, tirofiban, eptifibatide and the fibrinogen inhibiting peptide were related to fibrinogen function they didn't inhibit RBCA completely. Therefore, under moderate and low red blood cell aggregation the cell binding is probably related to nonspecific mode. It seems evident that the specific and nonspecific modes of red blood cell aggregate formation could co-exist. Additional theoretical and experimental investigations in this area are needed.

  2. Programmable type III-A CRISPR-Cas DNA targeting modules.

    Directory of Open Access Journals (Sweden)

    H Travis Ichikawa

    Full Text Available The CRISPR-Cas systems provide invader defense in a wide variety of prokaryotes, as well as technologies for many powerful applications. The Type III-A or Csm CRISPR-Cas system is one of the most widely distributed across prokaryotic phyla, and cleaves targeted DNA and RNA molecules. In this work, we have constructed modules of Csm systems from 3 bacterial species and heterologously expressed the functional modules in E. coli. The modules include a Cas6 protein and a CRISPR locus for crRNA production, and Csm effector complex proteins. The expressed modules from L. lactis, S. epidermidis and S. thermophilus specifically eliminate invading plasmids recognized by the crRNAs of the systems. Characteristically, activation of plasmid targeting activity depends on transcription of the plasmid sequence recognized by the crRNA. Activity was not observed when transcription of the crRNA target sequence was blocked, or when the opposite strand or a non-target sequence was transcribed. Moreover, the Csm module can be programmed to recognize plasmids with novel target sequences by addition of appropriate crRNA coding sequences to the module. These systems provide a platform for investigation of Type III-A CRISPR-Cas systems in E. coli, and for introduction of programmable transcription-activated DNA targeting into novel organisms.

  3. Safety of Neoadjuvant Bevacizumab plus Pemetrexed and Carboplatin 
in Patients with IIIa Lung Adenocarcinoma

    Directory of Open Access Journals (Sweden)

    Songliang ZHANG

    2015-06-01

    Full Text Available Background and objective Bevacizumab has showed its efficacy in advanced non-squamous lung cancer. The aim of this study is to assess the safety of bevacizumab plus pemetrexed and carboplatin neoadjuvant chemotherapy in patients with lung adenocarcinoma. Methods 25 patients with IIIa lung adenocarcinoma undergoing lobectemy or pneumonectomy with mediastinal lymphadenectomy after induction bevacizumab (Bev plus pemetrexed/carboplatin (PC were selected. Toxicity of chemotherapy and postoperative complications were analyzed. Results Grade 3 or 4 neoadjuvant-related adverse events included fatigue (3 patients, neutropenia (3 patients, hypertension (1 patient. The adverse events thought to be related to bevacizumab included epistaxis in 2 patients (grade 1: 1; grade 2: 1 and hypertension in 3 patients (grade 1: 2; grade 3: 1. Postoperative complications included pneumonia in 2 patients, bronchial stump insufficiency in 1 case, atelectasis in 2 cases, and arrhythmia in 1 case. Hemorrhage events, thromboembolic events and wound-healing problems were not observed in the perioperative period. Conclusion The treatment modality of neoadjuvant Bev-PC appears to be safe and tolerant in patients with stage IIIa lung adenocarcinoma.

  4. Secondary malignancies in patients with stage IA-IIIA Hodgkin's lymphoma after radiation (chemoradiation) therapy using accelerated dose fractionation

    International Nuclear Information System (INIS)

    Sinajko, V.V.; Minajlo, I.I.; Veyakin, I.V.

    2010-01-01

    The incidence of secondary malignancies was investigated in 367 patients with stage IA-IIIA Hodgkin's lymphoma after radiation therapy using accelerated fractionation. For 20 years of the observation 24 of them developed 27(7.4%) tumors, besides their frequency did not depend on the disease stage and method of treatment.

  5. Radiation Therapy, Chemotherapy, and Soy Isoflavones in Treating Patients With Stage IIIA-IIIB Non-Small Cell Lung Cancer

    Science.gov (United States)

    2017-05-23

    Adenocarcinoma of the Lung; Adenosquamous Cell Lung Cancer; Bronchoalveolar Cell Lung Cancer; Large Cell Lung Cancer; Recurrent Non-small Cell Lung Cancer; Squamous Cell Lung Cancer; Stage IIIA Non-small Cell Lung Cancer; Stage IIIB Non-small Cell Lung Cancer

  6. Health and Recovery Program in Increasing Physical Activity Level in Stage IA-IIIA Endometrial Cancer Survivors

    Science.gov (United States)

    2018-03-05

    Cancer Survivor; Endometrial Carcinoma; Stage I Uterine Corpus Cancer AJCC v7; Stage IA Uterine Corpus Cancer AJCC v7; Stage IB Uterine Corpus Cancer AJCC v7; Stage II Uterine Corpus Cancer AJCC v7; Stage IIIA Uterine Corpus Cancer AJCC v7

  7. 78 FR 57444 - Eagle Fund III-A, L.P.; Notice Seeking Exemption Under the Small Business Investment Act...

    Science.gov (United States)

    2013-09-18

    ... SMALL BUSINESS ADMINISTRATION [License No. 07/07-0117] Eagle Fund III-A, L.P.; Notice Seeking Exemption Under the Small Business Investment Act, Conflicts of Interest Notice is hereby given that Eagle..., Financings which Constitute Conflicts of Interest, of the Small Business Administration (``SBA'') Rules and...

  8. Antitumor Activity and Toxicity of Salts of Inorganic Group IIIa Metals: Aluminum, Gallium, Indium, and Thallium

    Science.gov (United States)

    Hart, Michael M.; Adamson, Richard H.

    1971-01-01

    The toxicity and antitumor activity of salts of the Group IIIa metals aluminum, gallium, indium, and thallium were determined. With the (lethal dose)50 as a measure, the decreasing order of toxicity was TlCl3 ≥ In(NO3)3 > Ga(NO3)3 > Al(NO3)3. All four metals exhibited antitumor activity, but when the tumor was inoculated by a route different from that of the drug, only Ga+3 and, to a lesser extent, In+3 inhibited tumor growth. Ga(NO3)3 was found to inhibit the growth of three out of four rodent solid tumors. Gallium therefore has potential therapeutic usefulness for treatment of solid tumors in man. PMID:5283954

  9. Natural Mallow Fiber-Reinforced Epoxy Composite for Ballistic Armor Against Class III-A Ammunition

    Science.gov (United States)

    Nascimento, Lucio Fabio Cassiano; Holanda, Luane Isquerdo Ferreira; Louro, Luis Henrique Leme; Monteiro, Sergio Neves; Gomes, Alaelson Vieira; Lima, Édio Pereira

    2017-10-01

    Epoxy matrix composites reinforced with up to 30 vol pct of continuous and aligned natural mallow fibers were for the first time ballistic tested as personal armor against class III-A 9 mm FMJ ammunition. The ballistic efficiency of these composites was assessed by measuring the dissipated energy and residual velocity after the bullet perforation. The results were compared to those in similar tests of aramid fabric (Kevlar™) commonly used in vests for personal protections. Visual inspection and scanning electron microscopy analysis of impact-fractured samples revealed failure mechanisms associated with fiber pullout and rupture as well as epoxy cracking. As compared to Kevlar™, the mallow fiber composite displayed practically the same ballistic efficiency. However, there is a reduction in both weight and cost, which makes the mallow fiber composites a promising material for personal ballistic protection.

  10. Neoadjuvant Chemoradiation Shows No Survival Advantage to Chemotherapy Alone in Stage IIIA Patients.

    Science.gov (United States)

    Krantz, Seth B; Mitzman, Brian; Lutfi, Waseem; Kuchta, Kristine; Wang, Chi-Hsiung; Howington, John A; Kim, Ki Wan

    2018-02-13

    For operable patients with clinical stage IIIA non-small cell lung cancer, the optimum neoadjuvant treatment strategy remains unclear. Our aim was to compare perioperative and long-term outcomes for patients receiving neoadjuvant chemoradiotherapy (NCRT) versus neoadjuvant chemotherapy (NCT) alone. We queried the National Cancer Database to identify all patients with N2 and either T1-T2 non-small cell lung cancer who received either NCRT or NCT followed by lobectomy between 2006 and 2012. Patients with T3 tumors were excluded. A propensity match analysis was performed incorporating preoperative variables, and the incidence of postoperative complications, pathologic downstaging, and long-term survival were compared. In all, 1,936 patients met criteria, 745 NCT and 1,191 NCRT. The NCRT patients were younger, less likely to be treated at an academic medical center, and more likely to have adenocarcinoma. After propensity matching, patients in the NCT group showed lower 30-day mortality (1.3% versus 2.9%) and 90-day mortality (2.9% versus 6.0%), and were more likely to undergo a minimally invasive resection (25.7% versus 14.1%). The NCRT patients were more likely to have a pathologic complete response (14.2% versus 4.0%) and to be N0 at the time of resection (45.2% versus 38.7%). In the multivariable analysis, NCRT patients were at a greater risk of mortality than NCT patients (hazard ratio 1.18, 95% confidence interval: 1.03 to 1.36). In our cohort, combined neoadjuvant chemotherapy and radiation therapy was associated with improved pathologic downstaging but showed increased perioperative mortality with no improvement in long-term overall survival. For stage IIIA patients with smaller tumors without local invasion, chemotherapy alone may be the preferred neoadjuvant treatment. Copyright © 2018 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  11. Platelet glycoprotein IIb/IIIa polymorphism HPA-3 b/b is associated with increased risk of ischemic stroke in patients under 60 years of age.

    Science.gov (United States)

    Duan, Hao; Cai, Yan; Sun, Xiaojiang

    2012-01-01

    The role of genetic risk factors in ischemic stroke is unclear. Platelet glycoprotein IIb/IIIa (GpIIb-IIIa) has been implicated in the pathogenesis of ischemic stroke. We sought to evaluate the relationship between the GpIIb/IIIa complex gene polymorphism and ischemic stroke. We investigated the association of the GpIIb/IIIa complex gene polymorphism with stroke risk in 306 patients with acute ischemic stroke and 266 control subjects by determining the GpIIb and GpIIIa genotype from leukocyte DNA by polymerase chain reaction (PCR) followed by FokI and ScrFI digestion, respectively. Compared with controls, more patients presented with coronary heart disease, hypertension, smoking history, and diabetes. In addition, the patients had higher levels of cholesterol and glucose compared with the control subjects. All donors in the GpIIIa (n=572) group expressed the GpIIIa PlA1 (HPA-1 aa) phenotype. There were no significant differences between the HPA-3 genotype (GpIIb) patient distribution (aa=39.9%, ab=41.4%, bb=28.7%) and healthy control subjects (aa=36.1%, ab=35.0%, bb=28.9%) (P=0.580). Among study participants ischemic stroke >2-fold (P=0.008). The GpIIb Ile/Ser843 gene polymorphism is associated with ischemic stroke among young and middle-aged adults (ischemic stroke.

  12. CLINICAL AND GENETIC CHARACTERISTICS OF MUCOLIPIDOSIS II AND IIIA TYPES IN CHILDREN

    Directory of Open Access Journals (Sweden)

    A. N. Semyachkina

    2017-01-01

    Full Text Available The article is devoted to a rare pathology from a group of accumulation diseases with an autosomal recessive type of inheritance – mucolipidosis II and IIIA types. The disease is characterized by a greater phenotypic similarity to mucopolysaccharidosis.Objective: analysis of genophenotypic parameters in Russian patients with mucolipidosis II and IIIA types. The activity of lysosomal enzymes in plasma (β-glucuronidase, total hexosaminidase and N-acetyl-α-D-glucosaminidase was measured using a standard technique using chromogenic and fluorogenic substrates. Genomic DNA of peripheral blood leukocytes was isolated using a set of reagents Preb 100 (DIAtomTM. Amplification of all exons of the GNPTAB gene was carried out by polymerase chain reaction (PCR followed by direct non-radioactive sequencing by Sanger.50 patients aged from 1.5 to 10 years were examined. The clinical symptoms of the disease included: a Hurler-like phenotype, growth retardation, skeletal, cardiac and vascular damage, and CNS. Mucolipidosis type II (I-cell disease was characterized by a more severe course. The clinical diagnosis was confirmed by the results of laboratory methods of investigation: normal parameters of renal excretion of glycosiminoglycans (GAG, high (5-15 times higher than normal activity of lysosomal hydrolases in blood plasma and detection of mutations in the GNPTAB gene.35 probands are completely genotyped. In 8 patients only 8 mutant alleles were detected; 7 mutations were not detected. Six new mutations in exons 1 (p.I31N; p.Q36P, 10 (p.L398P, 11 (p.W446X and 13 (p.S738X; c.2250delT were found, including a frequent mutation for Russian patients P.S738X (21% alleles. The most common (31.4% alleles in the Russian cohort of patients was a known small deletion c. 3503_3504delTC, leading to a reading frameshift.A clinical observation of a child with type 2 mucolipidosis (I-cell disease with typical symptomatology of the disease caused by two nonsense mutations

  13. [Identification of a novel mutation of AGL gene in two siblings affected with glycogen storage disease type IIIa].

    Science.gov (United States)

    Guo, Li; Lin, Weixia; Mao, Man; Song, Yuanzong

    2017-08-10

    To detect potential mutation of the AGL gene in two siblings affected with glycogen storage disease type IIIa. Clinical data of the two siblings was collected and analyzed. Genomic DNA was extracted from peripheral venous blood samples from the patients and their parents. All exons and their flanking sequences of the AGL gene were subjected to PCR amplification and Sanger sequencing. Suspected mutation was verified in 75 healthy controls. The main clinical features of the two siblings included hypoglycemia and hepatomegaly, along with markedly elevated liver and myocardial enzymes. Genetic analysis revealed that both siblings harbored compound heterozygous mutations c.1735+1G>T and c.959-1G>C of the AGL gene. Among these, the splicing mutation c.959-1G>C was a novel one with an allele frequency of glycogen storage disease type IIIa. The c.959-1G>C has enriched the spectrum of AGL gene mutations.

  14. Increased risk for vascular complications due to GP IIb/IIIa-antagonists in patients with cardiogenic shock supported by intraaortic balloon pump (IABP

    Directory of Open Access Journals (Sweden)

    Jens Röther

    2015-08-01

    Conclusion: Vascular events with the use of IABP are common but in our study, not significantly associated with a higher mortality. Treatment with GP IIb/IIIa-antagonists is associated with a higher risk of vascular events.

  15. Comparison of clinical and surgical-pathological staging in IIIA non-small cell lung cancer patients.

    Science.gov (United States)

    Muehling, Bernd; Wehrmann, Caren; Oberhuber, Alexander; Schelzig, Hubert; Barth, Thomas; Orend, Karl Heinz

    2012-01-01

    The heterogeneous group of IIIA NSCLC patients requires careful preoperative clinical staging as tumor size and lymph node involvement guide treatment. The purpose of our study was to analyze the correctness of clinical staging in IIIA patients. Retrospective analysis of all patients resected due to lung cancer that had been staged IIIA either clinically using invasive and noninvasive techniques or surgical-pathologically after surgical resection. Correctness, sensitivity, specificity, and positive and negative predictive values of clinical staging were calculated. From our tumor database, 49 patients who met the inclusion criteria were identified. The histology of the primary tumor included adenocarcinoma (53%), squamous cell carcinoma (41%), and other (6%). Preoperative clinical staging consisted of computed tomography (CT), integrated positron emission tomography-CT (PET-CT), bronchoscopy, and mediastinoscopy. The predominant surgical procedures performed were lobectomies (57%) and pneumonectomies (29%). Clinical staging for UICC, T and N stage was correct in 36.7, 38.7, and 40.8%, respectively. In terms of T4 stage, sensitivity was 28.5%, specificity was 80.9%, positive predictive value was 20%, and negative predictive value was 87.1%. As for N2 involvement, we found a sensitivity of 66.6% and a specificity of 35.7%. Positive and negative predictive values for N2 involvement were 43.7 and 58.8% in that order. Despite multimodal preoperative invasive and noninvasive staging techniques, the correctness of clinical staging in IIIA NSCLC patients is low. Hence, in doubt more invasive staging or probatory thoracotomy should be performed not to deny potentially curative surgery in those patients.

  16. Annotated bibliography for liquid metal surface tensions of groups III-A, IV-A, and V-A metals

    International Nuclear Information System (INIS)

    Murtha, M.J.; Burnet, G.

    1976-04-01

    An annotated bibliography has been prepared which includes summaries of 82 publications dating from 1920 and dealing with the measurement of the surface tensions of Groups III-A, IV-A, and V-A metals in the liquid state. The bibliography is organized by key element investigated, and contains a tabulation of correlations for surface tension as a function of temperature. A brief discussion dealing with variables and methods has been included

  17. Risk factors of brain metastases in completely resected pathological stage IIIA-N2 non-small cell lung cancer

    Directory of Open Access Journals (Sweden)

    Ding Xiao

    2012-07-01

    Full Text Available Abstract Background Brain metastases (BM is one of the most common failures of locally advanced non-small cell lung cancer (LA-NSCLC after combined-modality therapy. The outcome of trials on prophylactic cranial irradiation (PCI has prompted us to identify the highest-risk subset most likely to benefit from PCI. Focusing on patients with completely resected pathological stage IIIA-N2 (pIIIA-N2 NSCLC, we aimed to assess risk factors of BM and to define the highest-risk subset. Methods Between 2003 and 2005, the records of 217 consecutive patients with pIIIA-N2 NSCLC in our institution were reviewed. The cumulative incidence of BM was estimated using the Kaplan–Meier method, and differences between the groups were analyzed using log-rank test. Multivariate Cox regression analysis was applied to assess risk factors of BM. Results Fifty-three (24.4 % patients developed BM at some point during their clinical course. On multivariate analysis, non-squamous cell cancer (relative risk [RR]: 4.13, 95 % CI: 1.86–9.19; P = 0.001 and the ratio of metastatic to examined nodes or lymph node ratio (LNR ≥ 30 % (RR: 3.33, 95 % CI: 1.79–6.18; P = 0.000 were found to be associated with an increased risk of BM. In patients with non-squamous cell cancer and LNR ≥ 30 %, the 5-year actuarial risk of BM was 57.3 %. Conclusions In NSCLC, patients with completely resected pIIIA-N2 non-squamous cell cancer and LNR ≥ 30 % are at the highest risk for BM, and are most likely to benefit from PCI. Further studies are warranted to investigate the effect of PCI on this subset of patients.

  18. Paul Scherrer Institut annual report 1995. Annex IIIA: Solid state research at large facilities

    International Nuclear Information System (INIS)

    Baltensperger, U.; Lorenzen, R.

    1996-01-01

    The PSI research department IIIA is engaged in the final push to establish two research facilities: - the spallation neutron source (SINQ) and its instrumentation, - a positron source with high beam quality. The latter is essentially completed and ready for commissioning. The laboratory for Ion Beam Physics again served to many institutions with their accelerator mass spectroscopy by analyzing about 4000 samples. The new gas-jet facility and the neutron activation system at SINQ will be most important for the work of the laboratory of Radio- and Environmental Chemistry. Hence considerable effort has been put into the conception of this insertion device at the spallation source. Like in the previous year the laboratory of Neutron scattering was still relying on the access to neutron sources elsewhere than PSI. Regular access was available at ILL at a powder diffractometer and a triple axis spectrometer, upgraded and operated by PSI. Hence, besides the work for the instrumentation of SINQ, we had the opportunity to keep the scientific activities alive. Results of the laboratory of Astrophysics: one of the Radiation Environmental Monitors (REM) has now been in orbit for more than one year aboard the UK-satellite STRV-1B. The other monitor on a low circular orbit of a MIR-station also reports its results since about one year. (author) figs., tabs., refs

  19. Paul Scherrer Institut annual report 1995. Annex IIIA: Solid state research at large facilities

    Energy Technology Data Exchange (ETDEWEB)

    Baltensperger, U.; Lorenzen, R. [eds.

    1996-10-01

    The PSI research department IIIA is engaged in the final push to establish two research facilities: - the spallation neutron source (SINQ) and its instrumentation, - a positron source with high beam quality. The latter is essentially completed and ready for commissioning. The laboratory for Ion Beam Physics again served to many institutions with their accelerator mass spectroscopy by analyzing about 4000 samples. The new gas-jet facility and the neutron activation system at SINQ will be most important for the work of the laboratory of Radio- and Environmental Chemistry. Hence considerable effort has been put into the conception of this insertion device at the spallation source. Like in the previous year the laboratory of Neutron scattering was still relying on the access to neutron sources elsewhere than PSI. Regular access was available at ILL at a powder diffractometer and a triple axis spectrometer, upgraded and operated by PSI. Hence, besides the work for the instrumentation of SINQ, we had the opportunity to keep the scientific activities alive. Results of the laboratory of Astrophysics: one of the Radiation Environmental Monitors (REM) has now been in orbit for more than one year aboard the UK-satellite STRV-1B. The other monitor on a low circular orbit of a MIR-station also reports its results since about one year. (author) figs., tabs., refs.

  20. Risk factors of postoperative nosocomial pneumonia in stage I-IIIa lung cancer patients.

    Science.gov (United States)

    Wang, Zeng; Cai, Xin-Jun; Shi, Liang; Li, Fei-Yan; Lin, Neng-Ming

    2014-01-01

    To investigate the related risk factors of postoperative nosocomial pneumonia (POP) in patients with I-IIIa lung cancer. Medical records of 511 patients who underwent resection for lung cancer between January 2012 to December 2012 were retrospectively reviewed. Risk factors of postoperative pneumonia were identified and evaluated by univariate and multivariate analyses. The incidence of postoperative pneumonia in these lung cancer patients was 2.9% (15 cases). Compared with 496 patients who had no pneumonia infection after operation, older age (>60), histopathological type of squamous cell carcinoma and longer surgery time (>3h) were significant risk factors by univariate analysis. Other potential risk factors such as alcohol consumption, history of smoking, hypersensitivity, hypertension, diabetes mellitus and so on were not showed such significance in this study. Further, the multivariate analysis revealed that old age (>60 years) (OR 5.813, p=0.018) and histopathological type of squamous cell carcinoma (OR 5.831, prisk factors for postoperative pneumonia. This study demonstrated that being old aged (>60 years) and having squamous cell carcinoma histopathological type might be important factors in determining the risk of postoperative pneumonia in lung cancer patients after surgery.

  1. Safety and preliminary efficacy of one month glycoprotein IIb/IIIa inhibition with lefradafiban in patients with acute coronary syndromes without ST-elevation; a phase II study.

    OpenAIRE

    Akkerhuis, Martijn; Neuhaus, Karl; Wilcox, Robert; Vahanian, Alec; Boland, Jean; Hoffmann, J.; Baardman, Taco; Nehmiz, G.; Roth, U.; Klootwijk, Peter; Deckers, Jaap; Simoons, Maarten

    2000-01-01

    textabstractAIMS: Oral glycoprotein IIb/IIIa inhibitors might enhance the early benefit of an intravenous agent and prevent subsequent cardiac events in patients with acute coronary syndromes. We assessed the safety and preliminary efficacy of 1 month treatment with three dose levels of the oral GP IIb/IIIa blocker lefradafiban in patients with unstable angina or myocardial infarction without persistent ST elevation. METHODS: The Fibrinogen Receptor Occupancy STudy (FROST) was designed as a d...

  2. National patterns of care and outcomes after combined modality therapy for stage IIIA non-small-cell lung cancer.

    Science.gov (United States)

    Patel, Aalok P; Crabtree, Traves D; Bell, Jennifer M; Guthrie, Tracey J; Robinson, Clifford G; Morgensztern, Daniel; Colditz, Graham A; Kreisel, Daniel; Krupnick, A Sasha; Bradley, Jeffrey D; Patterson, G Alexander; Meyers, Bryan F; Puri, Varun

    2014-05-01

    The role of surgery in addition to chemotherapy and radiation for stage IIIA non-small-cell lung cancer (NSCLC) remains controversial. Because there are limited data on the benefit from surgery in this setting, we evaluated the use of combined modality therapy nationally and explored the outcomes with and without the addition of surgery. Patient variables and treatment-related outcomes were abstracted for patients with clinical stage IIIA NSCLC from the National Cancer Database. Patients receiving chemotherapy and radiation were compared with those undergoing chemotherapy, radiation, and surgery (CRS) in any sequence. Between 1998 and 2010, 61,339 patients underwent combined modality treatment for clinical stage IIIA NSCLC. Of these, 51,979 (84.7%) received chemotherapy and radiation while 9360 (15.3%) underwent CRS. Patients in the CRS group were younger, more likely female patients and Caucasians, and had smaller tumors and lower Charlson comorbidity scores. The 30-day surgical mortality was 200 of 8993 (2.2%). The median overall survival favored the CRS group in both unmatched (32.4 months versus 15.7 months, p therapy seem to have better long-term survival.

  3. Clinical Application of Adjuvant Treatment after Operation in Patients with Stage IIIa Non-small Cell Lung Cancer

    Directory of Open Access Journals (Sweden)

    Yajie GAO

    2010-04-01

    Full Text Available Background and objective The efficacy of complete resection of the cancer for patients with stage IIIa non-small cell lung cancer (NSCLC is limited. Synthetic therapy is taken the lead in advocating at present. However, the value of post-operative radiotherapy is not still clear. The aim of this study is to evaluate the survival time and side effects of postoperative chemotherapy or chemoradiotherapy in the treatment of stage IIIa NSCLC. Methods Between December 2003 and June 2007, 52 cases that have completed followed-up data with stage IIIa of NSCLC received in the First Affiliated Hospital of Dalian Medical University. Twenty-three patients received postoperative chemoradiotherapy (group A and 29 patients received postoperative chemotherapy combined with radiotherapy (group B. Group A adopted platinum-based combination chemotherapy for 4-6 cycles. The chemotherapeutics included gemcitabine, vinorelbine and docetaxel. Group B used chemotherapy for 2-4 cycles and then received 3-dimensional conformal radiotherapy (3D-CRT. The prescribe dose of target volume was 50 Gy. The chemotherapy was same as for group A and needed 4 cycles in all. The impact of postoperative adjuvant treatment on survival and toxicity was observed in patients with stage IIIa NSCLC and the reason of disease progression was analyzed. Results The median survival was 32.5 months in group A and 31.9 months in group B (P=0.371. Progression-free survival extended about 6 months (P=0.044. The survival rate was 87% at 1 year, 0.1% at 2 year, 33% at 3 year for group A compared with 93%, 69%, 45% for group B. The major side effects were hematological and gastrointestinal toxicities, including nausea, vomiting and neutropenia. There was no significant difference in these toxicities between the two groups (P>0.05. Radioactiv esophageal infection occurred in 17.2% of the patients. Acute and late radioactive lung infection occurred in 13.8% and 27.6% of the patients. All these toxicities

  4. Decay of 83Sr

    International Nuclear Information System (INIS)

    Yu Xiaohan; Shi Shuanghui; Gu Jiahui

    1997-01-01

    The decay of 83 Sr was reinvestigated using γ singles and γ-γ-t coincidence measurement. A new level scheme of Rb, which contains 41 excited levels and about 180 transitions, is constructed. 19 new levels were added to the old level scheme and 8 formerly adopted levels were denied. A new data set of branching ratio, log(ft) value and spin parity was obtained

  5. Pre-operative concurrent chemoradiotherapy for stage IIIA (N2) Non-Small cell lung cancer

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kyu Chan; Ahn, Yong Chan; Park, Keun Chil [College of Medicine, Sungkyunkwan Univ., Seoul (Korea, Republic of)] [and others

    1999-06-01

    This is to evaluate the acute complication, resection rate, and tumor down-staging after pre-operative concurrent chemoradiotherapy for stage IIIA (N2) non-small cell lung cancer. Fifteen patients with non-small cell lung cancer were enrolled in this study from May 1997 to June 1998 in Samsung Medical Center. The median age of the patients was 61 (range, 45-67) years and male to female ratio was 12:3. Pathologic types were squamous cell carcinoma (11) and adenocarcinoma (4). Pre-operative clinical tumor stages were cT1 in 2 patients, cT2 in 12, and cT3 in 1 and all were N2. Ten patients were proved to be N2 with mediastinoscopic biopsy and five had clinically evident mediastinal lymph node metastases on the chest CT scans. Pre-operative radiation therapy field included the primary tumor, the ipsilateral hilum, and the mediastinum. Total radiation dose was 45 Gy over 5 weeks with daily dose of 1.8 Gy. Pre-operative concurrent chemotherapy consisted of two cycles of intraventous cis-Platin (100 mg/m{sup 2}) on day 1 and oral Etoposide (50 mg/m{sup 2}/day) on days 1 through 14 with 4 weeks' interval. Surgery was followed after the pre-operative re-evaluation including chest CT scan in 3 weeks of the completion of the concurrent chemoradiotherapy if there was no evidence of disease progression. Full dose radiation therapy was administered to all the 15 patients. Planned two cycles of chemotherapy was completed in 11 patients and one cycle was given to four. One treatment related death of acute respiratory distress syndrome occurred in 15 days of surgery. Hospital admission was required in three patients including one with radiation pneumonitis and two with neutropenic fever. Hematologic complications and other acute complications including esophagitis were tolerable. Resection rate was 92.3% (12/13) in 13 patients excluding two patients who refused surgery. Pleural seeding was found in one patient after thoracotomy and tumor resection was not feasible. Post

  6. Reversal of glycogen storage disease type IIIa-related cardiomyopathy with modification of diet

    Science.gov (United States)

    Zori, R. T.; McCune, H.; Maisenbacher, M. K.; Ivsic, T.; Weinstein, D. A.

    2013-01-01

    Summary Glycogen storage disease type III (GSD III) is caused by a deficiency in debranching enzyme, which leads to an accumulation of abnormal glycogen called limit dextrin in affected tissues. Muscle and liver involvement is present in GSD type IIIa, while the defect is limited to the liver only in GSD type IIIb. Besides skeletal muscle involvement, a cardiomyopathy resembling idiopathic hypertrophic cardiomyopathy is seen. Management consists of maintaining normoglycaemia by supplementation with cornstarch therapy and/or protein. While studies are lacking regarding the best treatment for skeletal muscle disease, a high-protein diet was previously reported to be beneficial. No cases of improvement in cardiomyopathy have been reported. Our patient presented in infancy with hypoglycaemia and hepatomegaly. His prescribed management consisted of cornstarch supplementation and a high-protein diet providing 20% of his total energy needs. At 16 years of age, he developed a severe cardiomyopathy with a left ventricular mass index of 209 g/m2. The cardiomyopathy remained stable on a protein intake of 20–25% of total energy. At age 22 years, the diet was changed to increase his protein intake to 30% of total energy and minimize his cornstarch therapy to only what was required to maintain normoglycaemia. Dramatic improvement in the cardiomyopathy occurred. Over one year, his left ventricular mass index decreased from 159.7 g/m2 to 78 g/m2 (normal 50–86 g/m2) and the creatine kinase levels decreased from 455 U/L to 282 U/L. Avoidance of overtreatment with carbohydrate and a high-protein diet can reverse and may prevent cardiomyopathy. PMID:19322675

  7. Radius Core Decompression for Kienböck Disease Stage IIIA: Outcomes at 13 Years Follow-Up.

    Science.gov (United States)

    De Carli, Pablo; Zaidenberg, Ezequiel Ernesto; Alfie, Veronica; Donndorff, Agustin; Boretto, Jorge Guillermo; Gallucci, Gerardo Luis

    2017-09-01

    This study was designed to analyze the long-term clinical and radiological outcomes of a series of patients with Kienböck disease stage IIIA treated with radius core decompression. This retrospective study included 15 patients with Kienböck disease (Lichtman stage IIIA) who underwent distal radius metaphyseal core decompression between 1998 and 2005 and who were followed-up for at least 10 years. At the last follow-up, the patients were evaluated for wrist range of motion and grip strength. The overall results were evaluated by the modified Mayo wrist score and visual analog scale pain score. We also compared the radiological changes between the preoperative and the final follow-up in their Lichtman classification and the modified carpal height ratio. The mean follow-up period was 13 years (range, 10-18 years). Based on the modified Mayo wrist score, clinical results were excellent in 6 patients, good in 8 patients, and poor in 1 patient who required a proximal row carpectomy as revision surgery. The mean preoperative pain according to the visual analog scale was 7 (range, 6-10) and was 1.2 (range, 0-6) at the final follow-up. Compared with the opposite side, the average flexion/extension arc was 77% and the grip strength was 80%. All patients, except 1, returned to their original employment. At the final follow-up, 3 patients had decreased modified carpal height ratio, 12 remained unchanged. Radiographic disease progression according to the Lichtman classification to stages IIIB to IV occurred in only 2 wrists. There were no complications related to the core decompression. In this limited series, the radius core decompression demonstrated favorable long-term results and could be considered as a surgical alternative for stage IIIA of Kienböck disease. Therapeutic IV. Copyright © 2017 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.

  8. Increased platelet expression of glycoprotein IIIa following aspirin treatment in aspirin-resistant but not aspirin-sensitive subjects

    Science.gov (United States)

    Floyd, Christopher N; Goodman, Timothy; Becker, Silke; Chen, Nan; Mustafa, Agnesa; Schofield, Emma; Campbell, James; Ward, Malcolm; Sharma, Pankaj; Ferro, Albert

    2014-01-01

    Aims Aspirin is widely used as an anti-platelet agent for cardiovascular prophylaxis. Despite aspirin treatment, many patients experience recurrent thrombotic events, and aspirin resistance may contribute to this. We examined the prevalence of aspirin resistance in a healthy population, and investigated whether the platelet proteome differed in aspirin-resistant subjects. Methods Ninety-three healthy subjects received aspirin 300 mg daily for 28 days. Before and at the end of treatment, urine was taken to determine 11-dehydrothromboxane B2, and blood was taken to measure arachidonic acid (AA)-induced aggregation of platelet-rich plasma and to interrogate the platelet proteome by mass spectrometric analysis with further confirmation of findings using Western blotting. Results In two of the 93 subjects, neither AA-induced aggregation nor urinary 11-dehydrothromboxane B2 was effectively suppressed by aspirin, despite measurable plasma salicylate concentrations, suggesting the presence of true aspirin resistance. Despite no detectable differences in the platelet proteome at baseline, following aspirin a marked increase was seen in platelet glycoprotein IIIa expression in the aspirin-resistant but not aspirin-sensitive subjects. An increase in platelet glycoprotein IIIa expression with aspirin resistance was confirmed in a separate cohort of 17 patients with stable coronary artery disease on long term aspirin treatment, four of whom exhibited aspirin resistance. Conclusions In a healthy population, true aspirin resistance is uncommon but exists. Resistance is associated with an increase in platelet glycoprotein IIIa expression in response to aspirin. These data shed new light on the mechanism of aspirin resistance, and provide the potential to identify aspirin-resistant subjects using a novel biomarker. PMID:25099258

  9. [Mechanism of renal elimination of 2 elements of group IIIA of the periodic table : aluminum and indium].

    Science.gov (United States)

    Galle, P

    1981-01-05

    Aluminium and indium, two elements of group IIIA of the periodic table, are concentrated by the kidney inside lysosomes of proximal tubule cell. In these lysosomes, aluminium and indium are precipitated as non-soluble phosphate salts and these precipitates are then expelled in the tubular lumen and eliminated with the urinary flow. These data have been visualized by analytical microscopy (ion microscopy and X ray microanalysis). Local acid phosphatases are assumed to permit the concentration of aluminium and indium salts inside the lysosomes.

  10. Bivalirudin versus heparin with or without glycoprotein IIb/IIIa inhibitors in patients with STEMI undergoing primary percutaneous coronary intervention

    DEFF Research Database (Denmark)

    Stone, Gregg W; Mehran, Roxana; Goldstein, Patrick

    2015-01-01

    bleeding and mortality rates, but higher acute stent thrombosis rates compared with heparin + a glycoprotein IIb/IIIa inhibitor (GPI). Subsequent changes in primary PCI, including the use of potent P2Y12 inhibitors, frequent radial intervention, and pre-hospital medication administration, were incorporated...... approach was used in 21.3% of patients, prasugrel/ticagrelor was used in 18.1% of patients, and GPI was used in 84.8% of the control group. Bivalirudin compared with heparin ± GPI resulted in reduced 30-day rates of major bleeding (4.2% vs. 7.8%; relative risk [RR]: 0.53; 95% confidence interval [CI]: 0...

  11. Oral antiplatelet efficacy and specificity of a novel nonpeptide platelet GPIIb/IIIa receptor antagonist, DMP 802.

    Science.gov (United States)

    Mousa, S A; Olson, R E; Bozarth, J M; Lorelli, W; Forsythe, M S; Racanelli, A; Gibbs, S; Schlingman, K; Bozarth, T; Kapil, R; Wityak, J; Sielecki, T M; Wexler, R R; Thoolen, M J; Slee, A; Reilly, T M; Anderson, P S; Friedman, P A

    1998-08-01

    This study was undertaken to define the platelet glycoprotein alphaIIb beta3 integrin (GPII/IIIa) affinity, specificity, and oral antiplatelet efficacy of DMP 802, a small-molecule nonpeptide antiplatelet agent. Platelet GPIIb/IIIa integrin binding affinity and specificity for DMP 802 were determined by using binding and adhesion assays with cells from various species, including human. DMP 802 demonstrated a potent antiplatelet efficacy [median inhibitory concentration (IC50), 0.029 +/- 0.0042 microM] in inhibiting human platelet aggregation induced by 10 microM adenosine diphosphate (ADP), as assessed by light-transmittance aggregometry. DMP 802 inhibited 125I-fibrinogen binding to activated (ADP, epinephrine, and arachidonic acid at 100 microM each) gel purified human platelets with an IC50 of 0.012 +/- 0.003 microM. DMP 802 demonstrated tight association with unactivated human, baboon, or canine platelets (t(1/2) of dissociation, 32 +/- 2, 32 +/- 13, and 11 +/- 1 min, respectively). DMP 802 binds with high affinity to both unactivated and activated human platelets (Kd = 0.61 +/- 0.17, 0.57 +/- 0.21 nM, respectively). DMP 802 demonstrated species specificity in inhibiting platelet aggregation with IC50 values ranging from 0.025 to 0.092 microM (human, guinea pig, dog, swine, hamster) and 0.88-1.0 microM (rabbit and rat) in platelets obtained from these various species. DMP 802 demonstrated a high degree of specificity for platelet GPIIb/IIIa (alphaIIb/beta3) as compared with other integrins including alpha(v)beta3 (IC50, >10 microM), alpha(v)beta5 (IC50, >100 microM), alpha4beta1 (IC50, >100 microM), and alpha5beta1 (IC50, >10 microM). Oral antiplatelet efficacy of DMP 802 was examined after single oral (0.05-0.20 mg/kg) and after repeated oral dosing at 0.05 mg/kg daily for 5 days in mongrel dogs. Dose-dependent antiplatelet efficacy with an extended duration of antiplatelet efficacy was demonstrated based on ex vivo inhibition of platelet aggregation induced by

  12. Explorations of new selenites of the group IIIA and IVA metals

    International Nuclear Information System (INIS)

    Kong Fang; Li Peicin; Zhang Suyun; Mao Jianggao

    2012-01-01

    Systematic explorations of new phases in the Ga III /In III /Ge IV –Se IV –O systems by hydrothermal syntheses or solid-state reactions at high-temperature led to six new ternary compounds, namely, M 2 Se 2 O 7 (M=Ga 1, In 2), M(OH)(SeO 3 ) (M=Ga 3, In 4), α-Ge(SeO 3 ) 2 5 and β-Ge(SeO 3 ) 2 6. Ga 2 Se 2 O 7 1 displays a 3D open framework composed of 2D gallium oxide layers being further bridged and capped by SeO 3 groups. In 2 Se 2 O 7 2 features a 3D indium oxide framework formed by corner- and edge- sharing InO 6 octahedra with SeO 3 groups attached on the cavities and the 8-member ring tunnels of the structure. The isostructural of M(OH)(SeO 3 ) (M=Ga 3, In 4) exhibit a 2D metal selenite layer composed of 1D edge-sharing MO 6 octahedral chains that are interconnected by SeO 3 groups. α-Ge(SeO 3 ) 2 (P2 1 /n) 5 displays a 3D open framework with 1D 8-member ring tunnels along the a-axis while β-Ge(SeO 3 ) 2 (Pa-3) 6 exhibits a condensed 3D network. - Graphical abstract: Highlights: ► Up to now, selenites of the group IIIA and IVA metals are still rare. ► Hydrothermal or solid state reactions yielded six new compounds in this system. ► They are M 2 Se 2 O 7 (M=Ga, In), M(OH)(SeO 3 ) (M=Ga, In), α-Ge(SeO 3 ) 2 and β-Ge(SeO 3 ) 2 . ► They exhibit four different 3D and one 2D structural types. ► α-Ge(SeO 3 ) 2 and β-Ge(SeO 3 ) 2 represent the first examples of germanium selenites.

  13. Antiplatelet activity of L-sulforaphane by regulation of platelet activation factors, glycoprotein IIb/IIIa and thromboxane A2.

    Science.gov (United States)

    Oh, Chung-Hun; Shin, Jang-In; Mo, Sang Joon; Yun, Sung-Jo; Kim, Sung-Hoon; Rhee, Yun-Hee

    2013-07-01

    L-sulforaphane was identified as an anticarcinogen that could produce quinine reductase and a phase II detoxification enzyme. In recent decades, multi-effects of L-sulforaphane may have been investigated, but, to the authors' knowledge, the antiplatelet activation of L-sulforaphane has not been studied yet.In this study, 2 μg/ml of collagen, 50 μg/ml of ADP and 5 μg/ml of thrombin were used for platelet aggregations with or without L-sulforaphane. L-sulforaphane inhibited the platelet aggregation dose-dependently. Among these platelet activators, collagen was most inhibited by L-sulforaphane, which markedly decreased collagen-induced glycoprotein IIb/IIIa activation and thromboxane A2 (TxA2) formation in vitro. L-sulforaphane also reduced the collagen and epinephrine-induced pulmonary embolism, but did not affect prothrombin time (PT) in vivo. This finding demonstrated that L-sulforaphane inhibited the platelet activation through an intrinsic pathway.L-sulforaphane had a beneficial effect on various pathophysiological pathways of the collagen-induced platelet aggregation and thrombus formation as a selective inhibition of cyclooxygenase and glycoprotein IIb/IIIa antagonist. Thus, we recommend L-sulforaphane as a potential antithrombotic drug.

  14. Prognosis of stage pIIIA non small cell lung cancer after mediastinal lymph node dissection or sampling.

    Science.gov (United States)

    Misthos, P; Sepsas, E; Kokotsakis, J; Skottis, I; Lioulias, A

    2009-01-01

    The aim of this study was to define the impact of systematic mediastinal lymph node dissection (MLD) and mediastinal lymph node sampling (MLS) on the long-term results of patients suffering from non-small cell lung cancer (NSCLC) with N2 disease (pIIIA/N2). From 1999 to 2002, patients with NSCLC in stage pIIIA/N2 were retrospectively classified according to MLD or MLS procedure. Several clinical and pathological factors such as overall survival, disease-free interval, and complications were recorded and analyzed. Ninety-seven (64%) patients were subjected to MLD and 54 (35%) to MLS. Comparison between the two studied groups disclosed more frequent detection of one station pN2 nodes in MLS specimens (p <0.001), while skip metastasis was more often encountered after MLD (p=0.05). Duration of the operation, amount of postoperative bleeding and incidence of prolonged air leak were not significantly different between MLD and MLS groups. Cox regression analysis of all cases disclosed squamous histology as the only favorable factor of survival. The disease-free interval was significantly longer after MLD (p <0.001). Although radical lymphadenectomy did not offer significant prolongation of survival, the disease-free interval was significantly longer after MLD compared with MLS.

  15. Genomic clone encoding the α chain of the OKM1, LFA-1, and platelet glycoprotein IIb-IIIa molecules

    International Nuclear Information System (INIS)

    Cosgrove, L.J.; Sandrin, M.S.; Rajasekariah, P.; McKenzie, I.F.C.

    1986-01-01

    LFA-1, an antigen involved in cytolytic T lymphocyte-mediated killing, and Mac-1, the receptor for complement component C3bi, constitute a family of structurally and functionally related cell surface glycoproteins involved in cellular interactions. In both mouse and man, Mac-1 (OKM1) and LFA-1 share a common 95-kDa β subunit but are distinguished by their α chains, which have different cellular distributions, apparent molecular masses (165 and 177 kDa, respectively), and peptide maps. The authors report the isolation of a genomic clone from a human genomic library that on transfection into mouse fibroblasts produced a molecule(s) reactive with monoclonal antibodies to OKM1, to LFA-1, and to platelet glycoprotein IIb-IIIa. This gene was cloned by several cycles of transfection of L cells with a human genomic library cloned in λ phase Charon 4A and subsequent rescue of the λ phage. Transfection with the purified recombinant λ DNA yielded a transfectant that expressed the three human α chains of OKM1, LFA-1, and glycoprotein IIb-IIIa, presumably in association with the murine β chain

  16. Effect of PlA1/A2 glycoprotein IIIa gene polymorphism on the long-term outcome after successful coronary stenting

    Directory of Open Access Journals (Sweden)

    Riddell John

    2007-11-01

    Full Text Available Abstract Aim To prospectively determine the role of platelet glycoprotein IIIa (GP IIIa gene PlA1/PlA2 polymorphism on the long-term clinical outcome in patients with coronary artery disease undergoing coronary stenting. Design and setting Prospective observational study in the University Hospital of Caen (France. Patients and methods 1 111 symptomatic consecutive Caucasian patients treated with percutaneous coronary intervention including stent implantation underwent genotyping for GP IIIa PlA1/A2. Main outcome measures Long-term clinical outcome in terms of the rate of major adverse cardiac events (MACE, ie death from any cause, non-fatal Q wave or non Q wave myocardial infarction, and need for coronary revascularisation was obtained and subsequently stratified according to the GP IIIa PlA1/A2 polymorphism. Results Three groups of patients were determined according to the GP IIIa PlA1/A2 polymorphism (71.6% had the A1/A1, 25.8% had the A1/A2 and 2.6% had the A2/A2 genotype. These three groups were comparable for all clinical characteristics including sex ratio, mean age, vascular risk factors, previous coronary events, baseline angiographic exam, indication for the percutaneous coronary intervention and drug therapy. The incidence of MACE was similar in these 3 groups of patients during a mean follow-up period of 654+/-152 days. Independent risk factors for MACE were a left ventricular ejection fraction Conclusion The GP IIIa PlA1/A2 polymorphism does not influence the clinical long-term outcome in patients with symptomatic coronary disease undergoing percutaneous coronary intervention with stent implantation.

  17. Initial experience with a new femoral artery closure device following percutaneous coronary intervention with glycoprotein IIb/IIIa inhibition.

    Science.gov (United States)

    Ruygrok, Peter N; Ormiston, John A; Stewart, James T; Webster, Mark W I; El Jack, Seif; Simpson-Plaumann, Stephanie; Kay, I Patrick; Chou, Tony M

    2005-10-01

    The aim of the study was to determine the safety and efficacy of a novel femoral artery closure device (StarClose, Abbott Vascular Devices, Redwood City, CA) following percutaneous coronary intervention employing aspirin, heparin, and glycoprotein (GP) IIb/IIIa inhibition. A prospective nonrandomized single-center pilot study of the StarClose device included a subset of patients undergoing percutaneous coronary intervention utilizing GP IIb/IIIa inhibitors. Those that fulfilled the inclusion criteria (age < 80, no periprocedural haematoma, puncture above the superficial femoral and profunda femoralis artery bifurcation, no significant femoral artery disease) underwent closure of the femoral artery puncture site with a StarClose device immediately on completion of the procedure. Time to hemostasis (TTH), bleeding, mobilization, and short-term clinical follow-up data were collected, and an ultrasound scan of the femoral artery was performed 2 weeks later. Twenty-five patients were recruited, of whom 23 underwent percutaneous coronary intervention (PCI). Their mean age was 58 +/- 12 years, 84% were male, and 63% had unstable angina. All were on aspirin 100-150 mg daily and all PCI patients received i.v. heparin 4-10,000 units at commencement of the procedure and clopidogrel 600 mg on completion. Two patients were on a tirofiban infusion and 23 received a double bolus of eptifibatide, each 0.18 mg/kg, separated by 10 min. The procedural success was 100% and device success 23/25 (92%), with 1 failure due to technical error. The median device delivery time was 36 sec (range, 11-178) and median TTH 37 sec (range, 10-509 sec). There were no major adverse events. In 10 patients, a moderate amount of tract ooze required a short period of adjunctive manual compression. Follow-up ultrasound femoral artery scans revealed no compromise of the vessel lumen. Femoral artery closure with the device following coronary angiography and intervention using glycoprotein IIb/IIIa receptor

  18. High and prolonged sulfamidase secretion by the liver of MPS-IIIA mice following hydrodynamic tail vein delivery of antibiotic-free pFAR4 plasmid vector.

    Science.gov (United States)

    Quiviger, M; Arfi, A; Mansard, D; Delacotte, L; Pastor, M; Scherman, D; Marie, C

    2014-12-01

    Mucopolysaccharidosis type IIIA (MPS-IIIA) or Sanfilippo A syndrome is a lysosomal storage genetic disease that results from the deficiency of the N-sulfoglucosamine sulfohydrolase (SGSH) protein, a sulfamidase required for the degradation of heparan sulfate glycosaminoglycans (GAGs). The accumulation of these macromolecules leads to somatic organ pathologies, severe neurodegeneration and death. To assess a novel gene therapy approach based on prolonged secretion of the missing enzyme by the liver, mediated by hydrodynamic gene delivery, we first compared a kanamycin and an antibiotic-free expression plasmid vector, called pFAR4. Thanks to the reduced vector size, pFAR4 derivatives containing either a ubiquitous or a liver-specific promoter mediated a higher reporter gene expression level than the control plasmid. Hydrodynamic delivery of SGSH-encoding pFAR4 into MPS-IIIA diseased mice led to high serum levels of sulfamidase protein that was efficiently taken up by neighboring organs, as shown by the correction of GAG accumulation. A similar reduction in GAG content was also observed in the brain, at early stages of the disease. Thus, this study contributes to the effort towards the development of novel biosafe non-viral gene vectors for therapeutic protein expression in the liver, and represents a first step towards an alternative gene therapy approach for the MPS-IIIA disease.

  19. 77 FR 74545 - Eagle Fund III-A, L.P.; License No. 07/07-0117: Notice Seeking Exemption Under Section 312 of the...

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    2012-12-14

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  1. Safety and preliminary efficacy of one month glycoprotein IIb/IIIa inhibition with lefradafiban in patients with acute coronary syndromes without ST-elevation; a phase II study.

    NARCIS (Netherlands)

    K.M. Akkerhuis (Martijn); K.L. Neuhaus (Karl); R.G. Wilcox (Robert); A. Vahanian (Alec); J-L. Boland (Jean); J. Hoffmann; T. Baardman (Taco); G. Nehmiz; U. Roth; A.P.J. Klootwijk (Peter); J.W. Deckers (Jaap); M.L. Simoons (Maarten)

    2000-01-01

    textabstractAIMS: Oral glycoprotein IIb/IIIa inhibitors might enhance the early benefit of an intravenous agent and prevent subsequent cardiac events in patients with acute coronary syndromes. We assessed the safety and preliminary efficacy of 1 month treatment with three dose levels of the oral GP

  2. Combining low-molecular-weight heparin and glycoprotein IIb/IIIa antagonists for the treatment of acute coronary syndromes: the NICE 3 story. National Investigators Collaborating on Enoxaparin.

    Science.gov (United States)

    Ferguson, J J

    2000-12-01

    In recent years, a number of new therapies have become available that have significantly improved the care of patients with acute coronary syndromes (ACS). A number of studies have documented the significant superiority of the low-molecular-weight heparin (LMWH), enoxaparin, over unfractionated heparin (UFH) in the treatment of ACS. However, there are insufficient data regarding the safety of using LMWH in combination with glycoprotein (GP) IIb/IIIa antagonists. The NICE 3 study is an open-labeled, non-randomized, observational study examining the feasibility, safety, and preliminary efficacy of the LMWH, enoxaparin, in combination with each of the three commercially available GP IIb/IIIa antagonists in ACS patients. Approximately 600 patients at 45 clinical centers in North America will be divided between the three arms of the trial, representing each of the three GP IIb/IIIa antagonists. Once therapy is initiated, patients will receive no UFH (unless they require a coronary artery bypass graft) and will continue treatment even if invasive cath lab procedures are necessary. NICE 3 builds on the previous experiences of NICE 1 and NICE 4 with LMWH in the cath lab (with or without GP IIb/IIIa antagonists) to more aggressively extend the use of LMWHs into the medical management of ACS patients.

  3. Randomized controlled trial of resection versus radiotherapy after induction chemotherapy in stage IIIA-N2 non-small-cell lung cancer.

    NARCIS (Netherlands)

    Meerbeeck, J.P. van; Kramer, G.W.P.M.; Schil, P.E. van; Legrand, C.; Smit, E.F.; Schramel, F.M.; Tjan-Heijnen, V.C.; Biesma, B.; Debruyne, C.; Zandwijk, N. van; Splinter, T.A.; Giaccone, G.

    2007-01-01

    BACKGROUND: Induction chemotherapy before surgical resection increases survival compared with surgical resection alone in patients with stage IIIA-N2 non-small-cell lung cancer (NSCLC). We hypothesized that, following a response to induction chemotherapy, surgical resection would be superior to

  4. Randomized controlled trial of resection versus radiotherapy after induction chemotherapy in stage IIIA-N2 non-small-cell lung cancer

    NARCIS (Netherlands)

    J.P. van Meerbeeck (Jan); G.W.P.M. Kramer (Gijs); P.E.Y. van Schil (Paul); C. Legrand; E.F. Smit (Egbert); F.M.N.H. Schramel (Franz); V.C.G. Tjan-Heijnen (Vivianne); B. Biesma (Bonne); C. Debruyne (Channa); N. van Zandwijk (Nico); T.A.W. Splinter (Ted); G. Giaccone (Giuseppe)

    2007-01-01

    textabstractBackground: Induction chemotherapy before surgical resection increases survival compared with surgical resection alone in patients with stage IIIA-N2 non - small-cell lung cancer (NSCLC). We hypothesized that, following a response to induction chemotherapy, surgical resection would be

  5. RNA and DNA Targeting by a Reconstituted Thermus thermophilus Type III-A CRISPR-Cas System.

    Directory of Open Access Journals (Sweden)

    Tina Y Liu

    Full Text Available CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated systems are RNA-guided adaptive immunity pathways used by bacteria and archaea to defend against phages and plasmids. Type III-A systems use a multisubunit interference complex called Csm, containing Cas proteins and a CRISPR RNA (crRNA to target cognate nucleic acids. The Csm complex is intriguing in that it mediates RNA-guided targeting of both RNA and transcriptionally active DNA, but the mechanism is not well understood. Here, we overexpressed the five components of the Thermus thermophilus (T. thermophilus Type III-A Csm complex (TthCsm with a defined crRNA sequence, and purified intact TthCsm complexes from E. coli cells. The complexes were thermophilic, targeting complementary ssRNA more efficiently at 65°C than at 37°C. Sequence-independent, endonucleolytic cleavage of single-stranded DNA (ssDNA by TthCsm was triggered by recognition of a complementary ssRNA, and required a lack of complementarity between the first 8 nucleotides (5' tag of the crRNA and the 3' flanking region of the ssRNA. Mutation of the histidine-aspartate (HD nuclease domain of the TthCsm subunit, Cas10/Csm1, abolished DNA cleavage. Activation of DNA cleavage was dependent on RNA binding but not cleavage. This leads to a model in which binding of an ssRNA target to the Csm complex would stimulate cleavage of exposed ssDNA in the cell, such as could occur when the RNA polymerase unwinds double-stranded DNA (dsDNA during transcription. Our findings establish an amenable, thermostable system for more in-depth investigation of the targeting mechanism using structural biology methods, such as cryo-electron microscopy and x-ray crystallography.

  6. Scintigraphic detection of acute experimental endocarditis with the technetium-99m labelled glycoprotein IIb/IIIa receptor antagonist DMP444

    Energy Technology Data Exchange (ETDEWEB)

    Oyen, W.J.G.; Boerman, O.C.; Corstens, F.H.M. [Department of Nuclear Medicine, University Hospital Nijmegen, Nijmegen (Netherlands); Brouwers, F.M. [Department of Nuclear Medicine, University Hospital Nijmegen, Nijmegen (Netherlands); Department of Internal Medicine, University Hospital Nijmegen, Nijmegen (Netherlands); Barrett, J.A. [DuPont Pharmaceutical Company, Radiopharmaceutical Division, North Billerica, MA (United States); Verheugt, F.W.A. [Department of Cardiology, University Hospital Nijmegen, Nijmegen (Netherlands); Ruiter, D.J. [Department of Pathology, University Hospital Nijmegen, Nijmegen (Netherlands); Meer, J.W.M. van der [Department of Internal Medicine, University Hospital Nijmegen, Nijmegen (Netherlands)

    2000-04-01

    Bacterial endocarditis is an important clinical problem that may result in persistent bacteraemia and irreversible cardiac damage. Since endocarditis is characterized by aggregation of activated platelets, fibrin and bacteria, we studied DMP444, a technetium-99m labelled high-affinity antagonist of the GP IIb/IIIa receptor that is expressed on activated platelets. In seven Beagle dogs (11-15 kg), the left ventricle was catheterized via the right carotid artery. One hour later, 5 x 10{sup 7} colony forming units of Staphylococcus aureus were injected intracardially. Half an hour later, the catheter was removed. Two extra dogs underwent a complete sham procedure. One day after the intervention, five infected and the two non-infected dogs were injected with 37 MBq/kg {sup 99m}Tc-DMP444 and two infected dogs with 37 MBq/kg {sup 99m}Tc-IgG (used as a non-specific control agent) and imaged up to 4 h after injection. Samples were obtained for tissue counting, microbiology and histology. From 1 to 2 h post injection onward, there was clear focal accumulation of DMP444 in the aortic valve region when endocarditis was present, and this accumulation increased with time. The non-infected and the {sup 99m}Tc-IgG injected dogs showed only persisting blood pool activity without any focal abnormality. At 4 h post injection, the in vivo valve-to-blood pool ratios were 1.87{+-}0.18 in endocarditis, 1.01{+-}0.05 in non-infected controls and 1.09{+-}0.02 in {sup 99m}Tc-IgG injected dogs (P<0.05). It is concluded that targeting activated platelets with the {sup 99m}Tc-labelled GP IIb/IIIa antagonist DMP444 allows a final diagnosis of experimental bacterial endocarditis within 4 h owing to high, specific and fast in vivo uptake. (orig.)

  7. Scintigraphic detection of acute experimental endocarditis with the technetium-99m labelled glycoprotein IIb/IIIa receptor antagonist DMP444

    International Nuclear Information System (INIS)

    Oyen, W.J.G.; Boerman, O.C.; Corstens, F.H.M.; Brouwers, F.M.; Barrett, J.A.; Verheugt, F.W.A.; Ruiter, D.J.; Meer, J.W.M. van der

    2000-01-01

    Bacterial endocarditis is an important clinical problem that may result in persistent bacteraemia and irreversible cardiac damage. Since endocarditis is characterized by aggregation of activated platelets, fibrin and bacteria, we studied DMP444, a technetium-99m labelled high-affinity antagonist of the GP IIb/IIIa receptor that is expressed on activated platelets. In seven Beagle dogs (11-15 kg), the left ventricle was catheterized via the right carotid artery. One hour later, 5 x 10 7 colony forming units of Staphylococcus aureus were injected intracardially. Half an hour later, the catheter was removed. Two extra dogs underwent a complete sham procedure. One day after the intervention, five infected and the two non-infected dogs were injected with 37 MBq/kg 99m Tc-DMP444 and two infected dogs with 37 MBq/kg 99m Tc-IgG (used as a non-specific control agent) and imaged up to 4 h after injection. Samples were obtained for tissue counting, microbiology and histology. From 1 to 2 h post injection onward, there was clear focal accumulation of DMP444 in the aortic valve region when endocarditis was present, and this accumulation increased with time. The non-infected and the 99m Tc-IgG injected dogs showed only persisting blood pool activity without any focal abnormality. At 4 h post injection, the in vivo valve-to-blood pool ratios were 1.87±0.18 in endocarditis, 1.01±0.05 in non-infected controls and 1.09±0.02 in 99m Tc-IgG injected dogs (P 99m Tc-labelled GP IIb/IIIa antagonist DMP444 allows a final diagnosis of experimental bacterial endocarditis within 4 h owing to high, specific and fast in vivo uptake. (orig.)

  8. RNA and DNA Targeting by a Reconstituted Thermus thermophilus Type III-A CRISPR-Cas System.

    Science.gov (United States)

    Liu, Tina Y; Iavarone, Anthony T; Doudna, Jennifer A

    2017-01-01

    CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated) systems are RNA-guided adaptive immunity pathways used by bacteria and archaea to defend against phages and plasmids. Type III-A systems use a multisubunit interference complex called Csm, containing Cas proteins and a CRISPR RNA (crRNA) to target cognate nucleic acids. The Csm complex is intriguing in that it mediates RNA-guided targeting of both RNA and transcriptionally active DNA, but the mechanism is not well understood. Here, we overexpressed the five components of the Thermus thermophilus (T. thermophilus) Type III-A Csm complex (TthCsm) with a defined crRNA sequence, and purified intact TthCsm complexes from E. coli cells. The complexes were thermophilic, targeting complementary ssRNA more efficiently at 65°C than at 37°C. Sequence-independent, endonucleolytic cleavage of single-stranded DNA (ssDNA) by TthCsm was triggered by recognition of a complementary ssRNA, and required a lack of complementarity between the first 8 nucleotides (5' tag) of the crRNA and the 3' flanking region of the ssRNA. Mutation of the histidine-aspartate (HD) nuclease domain of the TthCsm subunit, Cas10/Csm1, abolished DNA cleavage. Activation of DNA cleavage was dependent on RNA binding but not cleavage. This leads to a model in which binding of an ssRNA target to the Csm complex would stimulate cleavage of exposed ssDNA in the cell, such as could occur when the RNA polymerase unwinds double-stranded DNA (dsDNA) during transcription. Our findings establish an amenable, thermostable system for more in-depth investigation of the targeting mechanism using structural biology methods, such as cryo-electron microscopy and x-ray crystallography.

  9. The temperate Burkholderia phage AP3 of the Peduovirinae shows efficient antimicrobial activity against B. cenocepacia of the IIIA lineage.

    Science.gov (United States)

    Roszniowski, Bartosz; Latka, Agnieszka; Maciejewska, Barbara; Vandenheuvel, Dieter; Olszak, Tomasz; Briers, Yves; Holt, Giles S; Valvano, Miguel A; Lavigne, Rob; Smith, Darren L; Drulis-Kawa, Zuzanna

    2017-02-01

    Burkholderia phage AP3 (vB_BceM_AP3) is a temperate virus of the Myoviridae and the Peduovirinae subfamily (P2likevirus genus). This phage specifically infects multidrug-resistant clinical Burkholderia cenocepacia lineage IIIA strains commonly isolated from cystic fibrosis patients. AP3 exhibits high pairwise nucleotide identity (61.7 %) to Burkholderia phage KS5, specific to the same B. cenocepacia host, and has 46.7-49.5 % identity to phages infecting other species of Burkholderia. The lysis cassette of these related phages has a similar organization (putative antiholin, putative holin, endolysin, and spanins) and shows 29-98 % homology between specific lysis genes, in contrast to Enterobacteria phage P2, the hallmark phage of this genus. The AP3 and KS5 lysis genes have conserved locations and high amino acid sequence similarity. The AP3 bacteriophage particles remain infective up to 5 h at pH 4-10 and are stable at 60 °C for 30 min, but are sensitive to chloroform, with no remaining infective particles after 24 h of treatment. AP3 lysogeny can occur by stable genomic integration and by pseudo-lysogeny. The lysogenic bacterial mutants did not exhibit any significant changes in virulence compared to wild-type host strain when tested in the Galleria mellonella moth wax model. Moreover, AP3 treatment of larvae infected with B. cenocepacia revealed a significant increase (P phage is a promising potent agent against bacteria belonging to the most common B. cenocepacia IIIA lineage strains.

  10. Survival in Operated Early and Local Advanced-Stage (IA-IIIA Non-Small Cell Lung Cancer

    Directory of Open Access Journals (Sweden)

    Mahsuk Taylan

    2016-06-01

    Full Text Available Objective: The early and local advanced stages (IA-IIIA of non-small cell lung cancer (NSCLC warrant the curative treatment approach of surgery. However, despite the surgical approach, survival depends on a number of factors. The aim of the study was to examine the factors that affect survival in operated NSCLC patients with these stages. Methods: A cohort of 231 operated patients with IA, IB, IIA, IIB, and IIIA stages of NSCLC were analyzed. The effects of age, sex, comorbidity, performance status, histopathology of the tumor, T stage, N stage, pleural invasion, surgical resection type and postoperative resection margin invasion on the survival of the patients were examined with Kaplan-Meier and Cox Regression analyses. Results: Advanced age (OR=1.042 for every passing year, CI=1.020-1.064, adenocarcinoma histopathology (OR=1.676 CI=1.178-2.384, N2 invasion (OR=2.389 CI=1.46-4.239, pleural invasion (OR=2.403 CI=1.569-3.678, resection margin invasion (OR=2.401, CI=1.141-5.048 and pneumonectomy as the type of surgical operation (OR=2.313, CI=1.467-3.647 were found to be independent prognostic factors of mortality. Conclusion: Follow-up of the NSCLC cases with advanced age, an adenocarcinoma type, visceral pleural invasion, N2-lymph node invasion, a history of pneumonectomy, and a resection margin invasion should be undertaken more atten­tively during planning of surgical operation and postoperative period. J Clin Exp Invest 2016; 7 (2: 125-133

  11. Photoelectron binding energy shifts observed during oxidation of group IIA, IIIA and IVA elemental surfaces

    International Nuclear Information System (INIS)

    Heide, P.A.W. van der

    2006-01-01

    An extensive re-evaluation of XPS binding energies (BE's) and binding energy shifts (ΔBE's) from metals, oxides and the carbonates of the group II, III and IVA elements (exceptions are Be, Mg and Hf) has been carried out using a substrate specific BE referencing approach. From this, O-1s BE's are found to fall into surface oxide, bulk oxide and carbonate groupings, with bulk oxides showing the lowest BE's followed by surface oxides (+∼1.5 eV) and then carbonates (+∼3.0 eV). The O-1s BE's from the bulk oxides also appear to scale with 1/d, where d is inter-atomic distance. The same is noted in the ΔBE's observed from the metallic counterparts during oxidation of the elemental surfaces. This, and the decreasing BE exhibited by Ca, Sr and Ba on oxidation is explained within the charge potential model as resulting from competing inter- and intra-atomic effects, and is shown to be consistent with partial covalency arguments utilizing Madulung potentials. The ΔBE's also fall into groups according to the elements location in the periodic table, i.e. s, p or d block. These trends open up the possibility of approximating ΔBE's arising from initial and final state effects, and bond distances

  12. The Frequency and Clinical Implication of ROS1 and RET Rearrangements in Resected Stage IIIA-N2 Non-Small Cell Lung Cancer Patients.

    Directory of Open Access Journals (Sweden)

    Sha Fu

    Full Text Available To evaluate the frequency and clinicopathological features of ROS1 and RET rearrangements in N2 node positive stage IIIA (IIIA-N2 non-small cell lung cancer (NSCLC patients, we retrospectively screened 204 cases with a tissue microarray (TMA panel by fluorescent in situ hybridization (FISH, and confirmed by direct sequencing and immunohistochemistry (IHC. The relationship between ROS1 or RET rearrangements, clinicopathological features, and prognostic factors were analyzed in resected stage IIIA-N2 NSCLC. Of the 204 cases, 4 cases were confirmed with ROS1 rearrangement, but no RET rearrangement was detected. All 4 ROS1-rearranged cases were adenocarcinomas. The predominant pathological type was acinar pattern in ROS1-rearranged tumors, except for 1 case harboring a mixture acinar and mucous tumor cells. Variants of ROS1 rearrangement were SDC4-ROS1 (E2:E32, SDC4-ROS1 (E4:E32 and SDC4-ROS1 (E4:E34. There was no significant association between ROS1 rearrangement and clinicopathological characteristics. In this cohort, multivariate analysis for overall survival (OS indicated that squamous cell carcinoma and lobectomy were independent predictors of poor prognosis; R0 surgical resection and non-pleural invasion were independent predictors of good prognosis. In resected stage IIIA-N2 NSCLC patients, ROS1-rearranged cases tended to occur in younger patients with adenocarcinomas. The prognosis of resected stage IIIA-N2 is generally considered poor, but patients with ROS1 rearrangement will benefit from the targeted therapy.

  13. Prognostic factors and long term results of neo adjuvant therapy followed by surgery in stage IIIA N2 non-small cell lung cancer patients

    Directory of Open Access Journals (Sweden)

    Li Jing

    2009-01-01

    Full Text Available Background: Prognosis of stage IIIA N2 non-small cell lung cancer (NSCLC remains poor despite the changes in therapeutic strategies. Objectives: To assess long term results of neo adjuvant therapy followed by surgery for patients with stage IIIA N2 NSCLC and to analyze factors influencing survival. Materials and Methods: The methods adopted include: Retrospective review of medical records of 91 patients with stage IIIA N2 NSCLC, who received neo adjuvant therapy followed by surgery; collection of information on demographic information, staging procedure, preoperative therapy, clinical response, type of resection, pathologic response of tumor, status of lymph nodes and adjuvant chemotherapy; survival analysis by Kaplan-Meier and calculation of prognostic factors using log-rank and Cox regression model. Results: All patients received a platinum-based chemotherapy and 23 (29.1% had an associated radiotherapy. Eighty four patients underwent thoracotomy. Median survival was 26 months (95%CI, 22.6-30.8 months with three and five year survival rates of 31.6 and 20.9%, respectively. Prognostic factors for survival on univariate analysis was clinical response (P = 0.032, complete resection (P = 0.002, pathologic tumor response ( P < 0.001, and lymph nodal down staging (P = 0.001. Multivariate analyses identified complete resection, pathologic tumor response and lymph nodal down staging as independent prognostic factors. Conclusion: Survival of patients with stage IIIA N2 NSCLC who received neo adjuvant therapy is significantly influenced by clinical response, complete resection, pathologic tumor response, and lymph nodal down staging. These results can be helpful in guiding standard clinical practice and evaluating the outcome of neo adjuvant therapy followed by surgery in patients with stage IIIA N2 NSCLC.

  14. Coral Sr-U Thermometry

    Science.gov (United States)

    DeCarlo, T. M.; Gaetani, G. A.; Cohen, A. L.; Foster, G. L.; Alpert, A.; Stewart, J.

    2016-12-01

    Coral skeletons archive the past two millennia of climate variability in the oceans with unrivaled temporal resolution. However, extracting accurate temperature information from coral skeletons is confounded by "vital effects", which often override the temperature dependence of geochemical proxies. Here, we present a new approach to coral paleothermometry based on results of abiogenic precipitation experiments interpreted within a framework provided by a quantitative model of the coral biomineralization process. We conducted laboratory experiments to test the temperature and carbonate chemistry controls on abiogenic partitioning of Sr/Ca and U/Ca between aragonite and seawater, and we modeled the sensitivity of skeletal composition to processes occurring at the site of calcification. The model predicts that temperature can be accurately reconstructed from coral skeleton by combining Sr/Ca and U/Ca ratios into a new proxy, Sr-U. We tested the model predictions with measured Sr/Ca and U/Ca ratios of fourteen Porites sp. corals collected from the tropical Pacific Ocean and the Red Sea, with a subset also analyzed using the boron isotope (δ11B) pH proxy. Observed relationships among Sr/Ca, U/Ca, and δ11B agree with model predictions, indicating that the model accounts for the key features of the coral biomineralization process. We calibrated Sr-U to instrumental temperature records and found that it captures 93% of mean annual variability (26-30 °C) and predicts temperature within 0.5 °C (1 σ). Conversely, Sr/Ca alone has an error of prediction of 1 °C and often diverges from observed temperature by 3 °C or more. Many of the problems afflicting Sr/Ca - including offsets among neighboring corals and decouplings from temperature during coral stress events - are reconciled by Sr-U. By accounting for the influence of the coral biomineralization process, the Sr-U thermometer may offer significantly improved reliability for reconstructing ocean temperatures from coral

  15. A method to determine 89Sr and 90Sr when they are in mixture

    International Nuclear Information System (INIS)

    Baha Al-Deen, A.H.; Baha Al-Deen, B.K. de

    1976-01-01

    89 Sr and 90 Sr are among the most dangerous types of radioactive fallout from biological view point. Particular concern about 89 Sr and 90 Sr is due to their chemical similarity to calcium. These radionuclides in water soluble form are absorbed by rain and they are eventually incorporated into human bones and teeth causing a potential danger to human life. Because of the great need for accurate measurement of 90 Sr in environmental samples which also contain 89 Sr and because no specific method has been published for the determination of 90 Sr and 89 Sr when they are in mixture, the following method was established: (1) enough time is allowed for the sample to reach the steady state between 90 Sr and its daughter 90 Y then the 90 Y is milked; (2) 90 Y is counted separately to determine the activity of 90 Sr; (3) the solution, after 90 Y is milked, is purified by hidroxide scavenging and counted for the combined 89 Sr and 90 Sr activity; (4) 89 Sr activity is determined by substracting the 90 Sr activity from the combined activity. The method has been applied by the authors to analyse an unknown solution of 89 Sr and 90 Sr at approximately environmental levels of activity obtaining the following results: (154+-19) dpm 90 Sr and (1210+-260) dpm 89 Sr per gram of original solution

  16. Procedural and clinical outcomes after use of the glycoprotein IIb/IIIa inhibitor abciximab for saphenous vein graft interventions

    International Nuclear Information System (INIS)

    Harskamp, Ralf E.; Hoedemaker, Niels; Newby, L. Kristin; Woudstra, Pier; Grundeken, Maik J.; Beijk, Marcel A.; Piek, Jan J.; Tijssen, Jan G.; Mehta, Rajendra H.; Winter, Robbert J. de

    2016-01-01

    Background: Percutaneous coronary intervention (PCI) of saphenous vein grafts (SVG) poses a high-risk for distal coronary thromboembolic events. Glycoprotein IIb/IIIa inhibitors are frequently used in hope of reducing the impact of this, although the safety and efficacy of these drugs to improve outcomes in this setting are understudied. Methods: Patients were included if they had prior coronary artery bypass surgery and subsequently underwent PCI of ≥ 1 SVG graft at a Dutch academic center between 1997 and 2008. These patients were matched 1:1 based on peri-procedural use of abciximab using a propensity-score matching algorithm based on 17 variables. Conditional logistic regression and Cox regression stratified on matched pairs were performed to evaluate the association between abciximab use and MACCE (the composite measure of mortality, myocardial infarction, stroke and repeat revascularization) at 30 days and up to 1 year. Results: The composite of 30-day MACCE occurred in 18 patients (15.3%) in the abciximab group and 16 patients (13.6%) in the propensity matched control group (OR: 1.13, 95% CI: 0.57–2.21, p = 0.73). At 1-year follow-up, MACCE rates were also similar (32.5% vs. 33.9%, HR: 0.97, 95% CI: 0.59–1.59). Major bleeding (BARC types 3a–c) was higher in the abciximab group (11.9% vs. 4.2%, OR: 2.80, 95% CI: 1.01–7.77). Ischemic outcomes did not differ among patients with acute coronary syndromes. Conclusion: The use of intravenous abciximab was not associated with improved clinical outcomes up to 1-year among patients undergoing SVG PCI, but was related to more bleeding. - Highlights: • PCI of SVG poses a high-risk for distal coronary thromboembolic events. • Glycoprotein IIb/IIIa inhibitors are frequently used in an attempt to reduce this risk. • We evaluated the safety and efficacy of abciximab (a glycoprotein IIb/IIIa inhibitor) using a propensity-score matched analysis of 236 patients at a large academic medical center. • Thirty

  17. Procedural and clinical outcomes after use of the glycoprotein IIb/IIIa inhibitor abciximab for saphenous vein graft interventions

    Energy Technology Data Exchange (ETDEWEB)

    Harskamp, Ralf E., E-mail: r.e.harskamp@gmail.com [Academic Medical Center–University of Amsterdam, Amsterdam (Netherlands); VU University Medical Center, Amsterdam (Netherlands); Duke Clinical Research Institute, Durham, NC (United States); Hoedemaker, Niels [Academic Medical Center–University of Amsterdam, Amsterdam (Netherlands); Newby, L. Kristin [Duke Clinical Research Institute, Durham, NC (United States); Woudstra, Pier; Grundeken, Maik J.; Beijk, Marcel A.; Piek, Jan J.; Tijssen, Jan G. [Academic Medical Center–University of Amsterdam, Amsterdam (Netherlands); Mehta, Rajendra H. [Duke Clinical Research Institute, Durham, NC (United States); Winter, Robbert J. de [Academic Medical Center–University of Amsterdam, Amsterdam (Netherlands)

    2016-01-15

    Background: Percutaneous coronary intervention (PCI) of saphenous vein grafts (SVG) poses a high-risk for distal coronary thromboembolic events. Glycoprotein IIb/IIIa inhibitors are frequently used in hope of reducing the impact of this, although the safety and efficacy of these drugs to improve outcomes in this setting are understudied. Methods: Patients were included if they had prior coronary artery bypass surgery and subsequently underwent PCI of ≥ 1 SVG graft at a Dutch academic center between 1997 and 2008. These patients were matched 1:1 based on peri-procedural use of abciximab using a propensity-score matching algorithm based on 17 variables. Conditional logistic regression and Cox regression stratified on matched pairs were performed to evaluate the association between abciximab use and MACCE (the composite measure of mortality, myocardial infarction, stroke and repeat revascularization) at 30 days and up to 1 year. Results: The composite of 30-day MACCE occurred in 18 patients (15.3%) in the abciximab group and 16 patients (13.6%) in the propensity matched control group (OR: 1.13, 95% CI: 0.57–2.21, p = 0.73). At 1-year follow-up, MACCE rates were also similar (32.5% vs. 33.9%, HR: 0.97, 95% CI: 0.59–1.59). Major bleeding (BARC types 3a–c) was higher in the abciximab group (11.9% vs. 4.2%, OR: 2.80, 95% CI: 1.01–7.77). Ischemic outcomes did not differ among patients with acute coronary syndromes. Conclusion: The use of intravenous abciximab was not associated with improved clinical outcomes up to 1-year among patients undergoing SVG PCI, but was related to more bleeding. - Highlights: • PCI of SVG poses a high-risk for distal coronary thromboembolic events. • Glycoprotein IIb/IIIa inhibitors are frequently used in an attempt to reduce this risk. • We evaluated the safety and efficacy of abciximab (a glycoprotein IIb/IIIa inhibitor) using a propensity-score matched analysis of 236 patients at a large academic medical center. • Thirty

  18. The Rb-Sr system

    International Nuclear Information System (INIS)

    Graham, I.J.

    1983-11-01

    This manual is intended to serve as a guide to the chemical procedures involved in Rb-Sr isotopic analysis as conducted at the Institute of Nuclear Sciences. Included are notes on the experimental developments made over the last 2.5 years, especially those involving rock dissolution and cation exchange chromatography

  19. Nivolumab, Cisplatin, and Pemetrexed Disodium or Gemcitabine Hydrochloride in Treating Patients With Stage I-IIIA Non-small Cell Lung Cancer That Can Be Removed by Surgery

    Science.gov (United States)

    2018-03-02

    Non-Squamous Non-Small Cell Lung Carcinoma; Stage I Non-Small Cell Lung Cancer; Stage IA Non-Small Cell Lung Carcinoma; Stage IB Non-Small Cell Lung Carcinoma; Stage II Non-Small Cell Lung Cancer; Stage IIA Non-Small Cell Lung Carcinoma; Stage IIB Non-Small Cell Lung Carcinoma; Stage IIIA Non-Small Cell Lung Cancer

  20. Insight into the mechanism of chemical modification of antibacterial agents by antibiotic resistance enzyme O-phosphotransferase-IIIA.

    Science.gov (United States)

    Power, Blake Hollett; Smith, Nathan; Downer, Brandon; Alisaraie, Laleh

    2017-01-01

    In the present work, the mechanism of resistance to aminoglycoside antibiotics was investigated. We examined the conformational changes of the O-phosphotransferase-IIIa enzyme, complexed with the antibiotics using MD simulations. The inhibitory effects of a group of antibacterial peptides against the enzyme were also examined, among which CP10A showed the highest affinity and the results correlated with the measured IC50 values. The regioselectivity of the phosphorylation reaction was shown to be in favor of the OH at the 5″ position versus the 3' of the antibiotic. The binding mode of CP10A was evaluated by means of MD simulation that resulted in recognizing its Trp8 and Arg13 residues binding near to where residues at the 3' and 5″ positions of the antibiotic would bind; thus, they are essential for the peptide inhibitory effect. The major open, semi-open, and closed conformations of the binding sites were identified throughout the MD trajectory, which enable the enzyme to regulate the influx of molecules into these sites. Based on the enzyme crystal structure, it was assumed that the 'antibiotic loop' of the enzyme is stable in its liganded mode; however, MD results revealed that the loop is highly flexible in both liganded and ligand-free modes. © 2016 John Wiley & Sons A/S.

  1. Crystal structure of the Csm3-Csm4 subcomplex in the type III-A CRISPR-Cas interference complex.

    Science.gov (United States)

    Numata, Tomoyuki; Inanaga, Hideko; Sato, Chikara; Osawa, Takuo

    2015-01-30

    Clustered, regularly interspaced, short palindromic repeat (CRISPR) loci play a pivotal role in the prokaryotic host defense system against invading genetic materials. The CRISPR loci are transcribed to produce CRISPR RNAs (crRNAs), which form interference complexes with CRISPR-associated (Cas) proteins to target the invading nucleic acid for degradation. The interference complex of the type III-A CRISPR-Cas system is composed of five Cas proteins (Csm1-Csm5) and a crRNA, and targets invading DNA. Here, we show that the Csm1, Csm3, and Csm4 proteins from Methanocaldococcus jannaschii form a stable subcomplex. We also report the crystal structure of the M. jannaschii Csm3-Csm4 subcomplex at 3.1Å resolution. The complex structure revealed the presence of a basic concave surface around their interface, suggesting the RNA and/or DNA binding ability of the complex. A gel retardation analysis showed that the Csm3-Csm4 complex binds single-stranded RNA in a non-sequence-specific manner. Csm4 structurally resembles Cmr3, a component of the type III-B CRISPR-Cas interference complex. Based on bioinformatics, we constructed a model structure of the Csm1-Csm4-Csm3 ternary complex, which provides insights into its role in the Csm interference complex. Copyright © 2014 Elsevier Ltd. All rights reserved.

  2. Structure and RNA-binding properties of the type III-A CRISPR-associated protein Csm3.

    Science.gov (United States)

    Hrle, Ajla; Su, Andreas A H; Ebert, Judith; Benda, Christian; Randau, Lennart; Conti, Elena

    2013-11-01

    The prokaryotic adaptive immune system is based on the incorporation of genome fragments of invading viral genetic elements into clusters of regulatory interspaced short palindromic repeats (CRISPRs). The CRISPR loci are transcribed and processed into crRNAs, which are then used to target the invading nucleic acid for degradation. The large family of CRISPR-associated (Cas) proteins mediates this interference response. We have characterized Methanopyrus kandleri Csm3, a protein of the type III-A CRISPR-Cas complex. The 2.4 Å resolution crystal structure shows an elaborate four-domain fold organized around a core RRM-like domain. The overall architecture highlights the structural homology to Cas7, the Cas protein that forms the backbone of type I interference complexes. Csm3 binds unstructured RNAs in a sequence non-specific manner, suggesting that it interacts with the variable spacer sequence of the crRNA. The structural and biochemical data provide insights into the similarities and differences in this group of Cas proteins.

  3. Functional correction of neurological and somatic disorders at later stages of disease in MPS IIIA mice by systemic scAAV9-hSGSH gene delivery

    Directory of Open Access Journals (Sweden)

    Haiyan Fu

    2016-01-01

    Full Text Available The reversibility of neuropathic lysosomal storage diseases, including MPS IIIA, is a major goal in therapeutic development, due to typically late diagnoses and a large population of untreated patients. We used self-complementary adeno-associated virus (scAAV serotype 9 vector expressing human N-sulfoglucosamine sulfohydrolase (SGSH to test the efficacy of treatment at later stages of the disease. We treated MPS IIIA mice at 1, 2, 3, 6, and 9 months of age with an intravenous injection of scAAV9-U1a-hSGSH vector, leading to restoration of SGSH activity and reduction of glycosaminoglycans (GAG throughout the central nervous system (CNS and somatic tissues at a dose of 5E12 vg/kg. Treatment up to 3 months age improved learning ability in the Morris water maze at 7.5 months, and lifespan was normalized. In mice treated at 6 months age, behavioral performance was impaired at 7.5 months, but did not decline further when retested at 12 months, and lifespan was increased, but not normalized. Treatment at 9 months did not increase life-span, though the GAG storage pathology in the CNS was improved. The study suggests that there is potential for gene therapy intervention in MPS IIIA at intermediate stages of the disease, and extends the clinical relevance of our systemic scAAV9-hSGSH gene delivery approach.

  4. Engagement of αIIbβ3 (GPIIb/IIIa) with ανβ3 Integrin Mediates Interaction of Melanoma Cells with Platelets

    Science.gov (United States)

    Lonsdorf, Anke S.; Krämer, Björn F.; Fahrleitner, Manuela; Schönberger, Tanja; Gnerlich, Stephan; Ring, Sabine; Gehring, Sarah; Schneider, Stefan W.; Kruhlak, Michael J.; Meuth, Sven G.; Nieswandt, Bernhard; Gawaz, Meinrad; Enk, Alexander H.; Langer, Harald F.

    2012-01-01

    A mutual relationship exists between metastasizing tumor cells and components of the coagulation cascade. The exact mechanisms as to how platelets influence blood-borne metastasis, however, remain poorly understood. Here, we used murine B16 melanoma cells to observe functional aspects of how platelets contribute to the process of hematogenous metastasis. We found that platelets interfere with a distinct step of the metastasis cascade, as they promote adhesion of melanoma cells to the endothelium in vitro under shear conditions. Constitutively active platelet receptor GPIIb/IIIa (integrin αIIbβ3) expressed on Chinese hamster ovary cells promoted melanoma cell adhesion in the presence of fibrinogen, whereas blocking antibodies to aνβ3 integrin on melanoma cells or to GPIIb/IIIa significantly reduced melanoma cell adhesion to platelets. Furthermore, using intravital microscopy, we observed functional platelet-melanoma cell interactions, as platelet depletion resulted in significantly reduced melanoma cell adhesion to the injured vascular wall in vivo. Using a mouse model of hematogenous metastasis to the lung, we observed decreased metastasis of B16 melanoma cells to the lung by treatment with a mAb blocking the aν subunit of aνβ3 integrin. This effect was significantly reduced when platelets were depleted in vivo. Thus, the engagement of GPIIb/IIIa with aνβ3 integrin interaction mediates tumor cell-platelet interactions and highlights how this interaction is involved in hematogenous tumor metastasis. PMID:22102277

  5. Rapid method for determining Sr-89 and Sr-90 using Cherenkov and proportional counting; Schnellmethode zur Bestimmung von SR-89 und SR-90 durch Cerenkov- und Proportionalzaehlermessungen

    Energy Technology Data Exchange (ETDEWEB)

    Lange, S.; Wende, C.; Schwokowski, R.; Alisch-Mark, M.; Abraham, A.; Heinrich, T. [Staatliche Betriebsgesellschaft fuer Umwelt und Landwirtschaft, Radebeul (Germany)

    2016-07-01

    A rapid method for determining Sr-89 and Sr-90 in water, milk and biological samples has been developed and tested. After sample preparation strontium is separated by extraction chromatography using Sr resin. Eluate is divided and transfered to LSC vial and filter paper by SrCO{sub 3} precipitation. A Hidex 300 SL TDCR liquid scintillation counter and Thermo Fisher low level proportional counter have been used. Chemical yield of Sr-85 tracer is determined by Gamma spectroscopy. Uncertainty budget, decision threshold and detection limit are calculated in accordance with GUM and ISO 11929.

  6. Smoking habits of patients with newly diagnosed stage IIIA/IIIB non-small cell lung cancer

    International Nuclear Information System (INIS)

    Sloan, J.; Bonner, J.A.; McGinnis, W.L.; Stella, P.; Marks, R.

    1997-01-01

    Purpose: This study was performed to assess the smoking habits and changes in the cigarette smoking habits of patients prior to, at the time of and after the diagnosis of unresectable stage IIIA/IIIB non-small cell lung cancer. Methods: Patients with the diagnosis of unresectable stage IIIA/IIIB non-small cell lung cancer who had agreed to enter a phase III North Central Cancer Treatment Group Trial comparing twice daily thoracic radiation therapy (TRT) given with chemotherapy to once daily TRT given with chemotherapy were asked to fill out a questionnaire regarding their past and present cigarette smoking habits. This questionnaire included information regarding the number of years of smoking, number of packs of cigarettes smoked per day and the time frame of smoking history. Subsequently, patients were given questionnaires to assess changes in smoking history at the halfway point of treatment, and during follow-up visits. Results: Of the 140 patients who were entered on the above noted trial, 132 filled out baseline questionnaires and were the subject of this study. Of these 132 patients, 126 (95%) had either smoked cigarettes in the past or smoked at the time of study entry. The median pack years of smoking. (years of smoking x packs per day) was 43 with a range of 3-169 pack years. Of the 126 patients with a smoking history, 124 provided information regarding the status of their smoking at the time of entry on the study: 89 (72%) claimed to have quit smoking and, 35 (28%) reported that they continued to smoke an average of one pack per day. Of the 89 patients who had quit smoking, roughly one third had quit within the month before study entry and 45% had quit during the 8 month period prior to entry on the study. Of the 35 patients who continued to smoke at the time of entry on the study, 21 indicated that they stopped smoking during the period following randomization. Hence 10% of the original 140 patients entered on study continued to smoke an average of one

  7. Pharmacokinetics, pharmacodynamics, and safety of a platelet GPIIb/IIIa antagonist, RGD891, following intravenous administration in healthy male volunteers.

    Science.gov (United States)

    Zannikos, P N; Rohatagi, S; Jensen, B K; DePhillips, S L; Massignon, D; Calic, F; Sibille, M; Kirkesseli, S

    2000-11-01

    The pharmacokinetics (PK), pharmacodynamics (PD), and safety of a platelet GPIIb/IIIa receptor antagonist, RGD891, and its active metabolite, RGD039, were evaluated after administration of various intravenous regimens of RGD891 to healthy male volunteers in two Phase I studies. Plasma and urine concentrations of RGD891 and RGD039 were measured by validated LC/MS/MS methods with minimum quantifiable limit (MQL) of 1 ng/mL and 10 ng/mL, respectively. PD activity was assessed by percent inhibition of ADP (20 microM)-induced platelet aggregation. Following intravenous dosing, the RGD891 was the predominant compound in plasma. The PK of RGD891 was dose independent associated with modest between-subject variability. RGD891 was rapidly cleared (Cl, 11.2-15.5 L/h), exhibited a restricted distribution (Vss, 23.0-25.9 L) and a short terminal t1/2 lambda z (1.2-2.1 h). Plasma concentrations of the metabolite (RGD039) increased with dose but were variable. RGD039 had longer t1/2 lambda z of 4.5 to 6.6 hours. Renal excretion of unchanged drug played an important role in the elimination of the parent compound. Both RGD891 and RGD039 exhibited renal clearance values that were comparable to the glomerular filtration rate. Intravenous administration of RGD891 effectively inhibited platelet aggregation in a dose-dependent and reversible manner. At the highest dose (60 micrograms/kg bolus dose + 336 micrograms/kg 8-h infusion) > 90% inhibition of platelet aggregation was achieved. PD activity was primarily attributed to the parent compound. Inhibition of platelet aggregation was dependent on the anticoagulant present, with samples containing PPACK showing 20% to 30% lower activity as compared to citrate. RGD891 was safe and well tolerated across the various regimens studies.

  8. Rapid determination of 90Sr in seawater

    International Nuclear Information System (INIS)

    Pavlotskaya, F.I.; Moskin, A.I.

    1994-01-01

    A method for determining 90 Sr in seawater that is based on direct isolation and radiochemical purification of daughter 90 Y is proposed. The analysis time is 6-8 h. The chemical yield of the Y-carrier during the 90 Sr determination from 35 liters of seawater varies in the range 37-69%. The analysis uncertainty is 90 Sr from seawater and subsequent isolation of 90 Y

  9. A founder AGL mutation causing glycogen storage disease type IIIa in Inuit identified through whole-exome sequencing: a case series.

    Science.gov (United States)

    Rousseau-Nepton, Isabelle; Okubo, Minoru; Grabs, Rosemarie; Mitchell, John; Polychronakos, Constantin; Rodd, Celia

    2015-02-03

    Glycogen storage disease type III is caused by mutations in both alleles of the AGL gene, which leads to reduced activity of glycogen-debranching enzyme. The clinical picture encompasses hypoglycemia, with glycogen accumulation leading to hepatomegaly and muscle involvement (skeletal and cardiac). We sought to identify the genetic cause of this disease within the Inuit community of Nunavik, in whom previous DNA sequencing had not identified such mutations. Five Inuit children with a clinical and biochemical diagnosis of glycogen storage disease type IIIa were recruited to undergo genetic testing: 2 underwent whole-exome sequencing and all 5 underwent Sanger sequencing to confirm the identified mutation. Selected DNA regions near the AGL gene were also sequenced to identify a potential founder effect in the community. In addition, control samples from 4 adults of European descent and 7 family members of the affected children were analyzed for the specific mutation by Sanger sequencing. We identified a homozygous frame-shift deletion, c.4456delT, in exon 33 of the AGL gene in 2 children by whole-exome sequencing. Confirmation by Sanger sequencing showed the same mutation in all 5 patients, and 5 family members were found to be carriers. With the identification of this mutation in 5 probands, the estimated prevalence of genetically confirmed glycogen storage disease type IIIa in this region is among the highest worldwide (1:2500). Despite identical mutations, we saw variations in clinical features of the disease. Our detection of a homozygous frameshift mutation in 5 Inuit children determines the cause of glycogen storage disease type IIIa and confirms a founder effect. © 2015 Canadian Medical Association or its licensors.

  10. [Resected non-small cell bronchogenic carcinoma stage pIIIA-N2. Which patients will benefit most from adjuvant therapy?].

    Science.gov (United States)

    Gómez, Ana M; Jarabo, José Ramón; Fernandez, Cristina; Calatayud, Joaquín; Fernández, Elena; Torres, Antonio J; Balibrea, José L; Hernando, Florentino

    2014-04-01

    Controversy persists as regards the indications and results of surgery in the treatment of patients with stage pIIIA-N2 non-small cell lung cancer (NSCLC). The objective of this study was to analyze the overall survival of a multicentre series of these patients and the role of adjuvant treatment, looking for factors that may define subgroups of patients with an increased benefit from this treatment. A retrospective study was conducted on 287 patients, with stage pIIIA-N2 NSCLC subjected to complete resection, taken from a multi-institutional database of 2.994 prospectively collected consecutive patients who underwent surgery for lung cancer. Adjuvant treatment was administered in 238 cases (82.9%). Analyses were made of the age, gender, histological type, administration of induction and adjuvant chemotherapy and/or radiation therapy treatments. The 5-year survival was 24%, with a median survival of 22 months. Survival was 26.5% among patients receiving with adjuvant treatment, versus 10.7% for those without it (P=.069). Age modified the effect of adjuvant treatment on survival (interaction P=.049). In patients under 70 years of age with squamous cell carcinoma, adjuvant treatment reduced the mortality rate by 37% (hazard ratio: 0,63; 95% CI; 0,42-0,95; P=.036). Completely resected patients with stage pIIIA-N2 NSCLC receiving adjuvant treatment reached higher survival rates than those who did not. Maximum benefit was achieved by the subgroup of patients under 70 years of age with squamous cell carcinoma. Copyright © 2012 AEC. Published by Elsevier Espana. All rights reserved.

  11. Pilot study of human recombinant interferon gamma and accelerated hyperfractionated thoracic radiation therapy in patients with unresectable stage IIIA/B nonsmall cell lung cancer

    International Nuclear Information System (INIS)

    Shaw, Edward G.; Deming, Richard L.; Creagan, Edward T.; Nair, Suresh; Su, John Q.; Levitt, Ralph; Steen, Preston D.; Wiesenfeld, Martin; Mailliard, James A.

    1995-01-01

    Purpose: Gamma interferon has a wide range of properties, including the ability to sensitize solid tumor cells to the effects of ionizing radiation. The North Central Cancer Treatment Group has previously completed pilot studies of accelerated hyperfractionated thoracic radiation therapy (AHTRT) in patients with unresectable Stage IIIA/B nonsmall cell lung cancer (NSCLC). This Phase I study was designed to assess the toxicity of concomitant gamma interferon and AHTRT in a similar patient population. Methods and Materials: Between December 1991 and May 1992, 18 patients with unresectable Stage IIIA/B NSCLC were treated with daily gamma interferon (0.2 mg subcutaneously) concomitant with AHTRT (60 Gy given in 1.5 Gy twice daily fractions). All patients had an Eastern Cooperative Oncology Group performance status of 0 or 1 with weight loss < 5%. Eight patients had Stage IIIA and 10 had Stage IIIB disease. Results: Nine patients (50%) experienced severe, life-threatening, or fatal toxicities. Eight of the patients (44%) developed significant radiation pneumonitis, which was severe in six patients and fatal in two patients (11% treatment-related mortality). Two patients (11%) developed severe radiation esophagitis. With follow-up of 15-21 months, 2 patients are alive, and 16 have died. The median survival time and 1-year survival rate is 7.8 months and 38%, respectively. Conclusion: Gamma interferon appeared to sensitize normal lung tissue to the effects of radiation, as demonstrated by the high incidence of severe or fatal radiation pneumonitis. We do not recommend pursuing gamma interferon as a radiosensitizer in this setting

  12. Negative effect of cyclin D1 overexpression on recurrence-free survival in stage II-IIIA lung adenocarcinoma and its expression modulation by vorinostat in vitro.

    Science.gov (United States)

    Lee, Eunju; Jin, DongHao; Lee, Bo Bin; Kim, Yujin; Han, Joungho; Shim, Young Mog; Kim, Duk-Hwan

    2015-12-17

    This study was aimed at identifying prognostic biomarkers for stage II-IIIA non-small cell lung cancer (NSCLC) according to histology and at investigating the effect of vorinostat on the expression of these biomarkers. Expression levels of cyclin D1, cyclin A2, cyclin E, and p16 proteins that are involved in the G1-to-S phase progression of cell cycle were analyzed using immunohistochemistry in formalin-fixed paraffin-embedded tissues from 372 samples of stage II-IIIA NSCLC. The effect of vorinostat on the expression of these proteins, impacts on cell cycle, and histone modification was explored in lung cancer cells. Abnormal expression of cyclin A2, cyclin D1, cyclin E, and p16 was found in 66, 47, 34, and 51 % of 372 cases, respectively. Amongst the four proteins, only cyclin D1 overexpression was significantly associated with poor recurrence-free survival (adjusted hazard ratio = 1.87; 95 % confidence interval = 1.12 - 2.69, P = 0.02) in adenocarcinoma but not in squamous cell carcinoma (P = 0.44). Vorinostat inhibited cell cycle progression to the S-phase and induced down-regulation of cyclin D1 in vitro. The down-regulation of cyclin D1 by vorinostat was comparable to a siRNA-mediated knockdown of cyclin D1 in A549 cells, but vorinostat in the presence of benzo[a]pyrene showed a differential effect in different lung cancer cell lines. Cyclin D1 down-regulation by vorinostat was associated with the accumulation of dimethyl-H3K9 at the promoter of the gene. The present study suggests that cyclin D1 may be an independent prognostic factor for recurrence-free survival in stage II-IIIA adenocarcinoma of lung and its expression may be modulated by vorinostat.

  13. Isotope ratio 87Sr/86Sr in limestones from Bambui group, Brazil (MG)

    International Nuclear Information System (INIS)

    Kawashita, K.; Mizusaki, A.M.P.; Kiang, C.H.

    1987-01-01

    The Sr composition of ancient seawater can be estimated from the analysis of carbonate rocks and, in some cases, used to estimate the age of the analyzed carbonate. The normalized 87Sr/86Sr ratios in calcium carbonate fractions from 14 core samples in the Bambui Group near Montalvania, MG, were found to range between .7077 and .7280. The higher values are attributable to Sr isotopic exchange between silicate and carbonate phases during diagenesis. The ratio of .7077 obtained in two pure calcium carbonate samples is here suggested as the best aproximation for the 87Sr/86Sr value for the Bambui sea. This ratio is compatible with an age of about 700 Ma., estimated from the published 87Sr/86Sr curve of Veizer and others, an age in accordance with Quadros recent (1987, in preparation) identification of marine acritarchs from the latest Precambrian (Vendian). (author) [pt

  14. beta decay of (78)Sr

    OpenAIRE

    Pérez-Cerdán, Ana Belén; Rubio, Berta; Gelletly, W.; Algora, Alejandro; Agramunt, Jorge; Burkard, K.; Huller W.; Nácher, Enrique; Sarriguren, Pedro; Caballero Ontanaya, Luis; Molina Palacios, Francisco Gabriel; Fraile, Luis M.; Reillo, E.; García Borge, María José; Dessagne, Ph.

    2011-01-01

    The gamma rays and conversion electrons emitted in the beta decay of (78)Sr to levels in (78)Rb have been studied using Ge detectors and a mini-orange spectrometer. A reliable level scheme based on the results of these experiments has been established. The properties of the levels in (78)Rb have been compared with calculations based on deformed Hartree-Fock with Skyrme interactions and pairing correlations in the BCS approximation. This has allowed an interpretation of the nature of the obser...

  15. Chernobyl 90Sr in bilberries from Poland

    International Nuclear Information System (INIS)

    Mietelski, J.W.; Vajda, N.

    1997-01-01

    As part of a detailed survey on the contamination of Polish forests 90 Sr activity concentrations were determined in bilberries. Elevated 90 Sr levels were found in several samples from north-eastern Poland. The calculated maximum 90 Sr surface contamination was 2 kBq*m -2 . The correlation between 90 Sr and 137 Cs concentrations in bilberries was good for two sets of samples originating from two geographical areas of Poland indicating the local differences in radionuclide depositions from Chernobyl fallout. (author)

  16. Experiences with the determination of Sr-89 and Sr-90 using fast methods; Erfahrungen bei der Bestimmung von {sup 89}Sr und {sup 90}Sr mittels Schnellmethoden

    Energy Technology Data Exchange (ETDEWEB)

    Kowalik, C.; Fueger, J. [Thueringer Landesanstalt fuer Umwelt und Geologie, Jena (Germany). Landesmessstelle fuer Umweltradioaktivaet

    2014-01-20

    Quick methods of the measurement of {sup 89}Sr and {sup 90}Sr have a great importance in the supervision of the environmental radioactivity. It is necessary to receive in short time dependable analytical data to be able to carry out suitable assessments or to give recommendations. The aim of the investigations was to be guaranteed the demands for these methods (test preparation, measurement and evaluation). The use of the solid phase extraction by means of commercial Sr Resin trademark columns (4.4' (5')-Di-tert-butylcyclohexanol-18-kronen-6-aether) (Triskem) to the radiochemical separation of the Sr isotopes was suitable. The measurements occurred to the FHT 770 T12 - Multi Low Level Alpha/Beta Sample Counter (Thermo Scientific). The results contain the summary activities of all available Sr isotopes, as for example {sup 89}Sr and {sup 90}Sr. The calculations of the single activities occur about the mathematical algorithm of the linear development on the basis of the works of G. Kanisch. The first results show, this method is suitable for the analysis of {sup 89}Sr and {sup 90}Sr and is used therefore in future in Thuringia.

  17. Preparation of 90Sr-90Y generator

    International Nuclear Information System (INIS)

    Jin Xiaohai; Yu Haibin; Zhang Jinming; Zhang Peixin; Lin Qiongfang

    1990-01-01

    In recent years, 90 Y has been considered as one of the best radionuclides for tumor radioimmunotherapy when chelated to tumor-associated antibodies. This evaluation is based on the superior properties of this radionuclide (suitable half-life, pure β-ray emitter of intermediate energy, stable daughters, and suitable chemical properties) and because it is available as a radionuclide generator product by decay of its 28a parent 90 Sr. The experimental conditions of 90 Sr- 90 Y generator are described. The elution efficiency of 90 Sr- 90 Y generator reaches 98%. One of the most important problems is the 90 Sr contamination breakthrough from the generator. The level of 90 Sr contamination must be controlled to the clinical standard. The cation exchange resin 732 (100-150 mesh) was successfully used for the separation of 90 Y from 90 Sr. The method used by the authors provides a 90 Y-HAc solution which is very simple and safe for administration to the patients. 90 Y was separated from 90 Sr almost completely, the level of the 90 Sr contamination per 740 MBq 90 Y product was only 0.74 kBq. However the toxicity of 90 Sr is extremely high, the human life-time permissible dose is 74 kBq, then 740 MBq of 90 Y is allowed to be administrated to a patient for 50-100 times

  18. Inhibition of tumor cell-induced platelet aggregation and lung metastasis by the oral GpIIb/IIIa antagonist XV454.

    Science.gov (United States)

    Amirkhosravi, Ali; Mousa, Shaker A; Amaya, Mildred; Blaydes, Susan; Desai, Hina; Meyer, Todd; Francis, John L

    2003-09-01

    Platelets are known to play a role in blood borne metastasis. Previous experimental studies have suggested that platelet GpIIb/IIIa may be a therapeutic target. However, the need for intravenous administration limits the potential application of current GpIIb/IIIa inhibitors to cancer therapy. The aim of the present study was to assess the efficacy of a novel, non-peptide oral GpIIb/IIIa antagonist (XV454) on tumor cell-induced platelet aggregation in vivo and on experimental metastasis. A Lewis lung carcinoma (LL2) mouse model of experimental metastasis was used in this study. XV454 (100 micro g) was administered intravenously (via tail vein) or orally (gavages) to 20 g mice. To determine the effect of XV454 on platelet aggregation, blood samples were collected by cardiac puncture 10 minutes after intravenous and 1-24 hrs after oral XV454, and platelet function was assessed by aggregometry, thrombelastography and the Platelet Function Analyzer (PFA100). The effect of XV454 on tumor cell-induced thrombocytopenia was determined 10 minutes after intravenous and 3 hrs after oral XV454 administration. Tumor cells (2 x 10(6)) were injected intravenously and 15 minutes after cell injection, platelet count was measured and compared to baseline (pre-injection) counts. To assess the effect on metastasis, XV454 was administered intravenous or orally 10 minutes and 3 hrs before tumor cell injection, respectively. Eighteen days later, surface lung tumor nodules were counted and the total lung tumor burden assessed. In a fourth group, in addition to the initial oral dose (before tumor cell injection), oral XV454 was given daily for the first week and three times in the second week. Administration of XV454 (5 mg/kg) completely inhibited platelet aggregation and this effect persisted for at least 24 hrs after oral delivery. Both intravenous and oral XV454 significantly inhibited tumor cell-induced thrombocytopenia (P < 0.01), the number of surface lung tumor nodules (80-85%; P

  19. Uterine cervix cancer treatment in IIB, IIIA and IIIB stages with external radiotherapy versus external radiotherapy and scintiscanning of low dose. ION SOLCA. Years 1998-2000

    International Nuclear Information System (INIS)

    Sanchez, Doris; Falquez, Roberto

    2002-01-01

    We realized study of retrospective accomplished in course of years 1998-2000, reviewing clinical charts of statistical department of ION SOLCA. We reviewed 544 cases in 1998, 603 patients in 1999, and 630 cases in 2000. In the radiotherapy service, 133 patients received treatment with external radiotherapy between February 1998 to February 1999 in IIB, IIIA, IIIB stages and only 80 patients were treated with external radiotherapy and scintiscanning of low dose rate in the same stages between March 1999 to March 2000. (The author)

  20. Effect of Wood Aging on Wine Mineral Composition and87Sr/86Sr Isotopic Ratio.

    Science.gov (United States)

    Kaya, Ayse D; Bruno de Sousa, Raúl; Curvelo-Garcia, António S; Ricardo-da-Silva, Jorge M; Catarino, Sofia

    2017-06-14

    The evolution of mineral composition and wine strontium isotopic ratio 87 Sr/ 86 Sr (Sr IR) during wood aging were investigated. A red wine was aged in stainless steel tanks with French oak staves (Quercus sessiliflora Salisb.), with three industrial scale replicates. Sampling was carried out after 30, 60, and 90 days of aging, and the wines were evaluated in terms of general analysis, phenolic composition, total polysaccharides, multielement composition, and Sr IR. Li, Be, Mg, Al, Sc, Ti, V, Mn, Co, Ni, Cu, Zn, Ga, Ge, As, Rb, Sr, Y, Zr, Mo, Sb, Cs, Ba, Pr, Nd, Sm, Eu, Dy, Ho, Er, Yb, Lu, Tl, and Pb elements and 87 Sr/ 86 Sr were determined by quadrupole inductively coupled plasma mass spectrometry (Q-ICP-MS) and Na, K, Ca, and Fe by flame atomic absorption spectrometry (FAAS). Two-way ANOVA was applied to assess wood aging and time effect on Sr IR and mineral composition. Wood aging resulted in significantly higher concentrations of Mg, V, Co, Ni, and Sr. At the end of the aging period, wine exhibited statistically identical Sr IR compared to control. Study suggests that wood aging does not affect 87 Sr/ 86 Sr, not precluding the use of this parameter for wine traceability purposes.

  1. Treatment-Related Predictive and Prognostic Factors in Trimodality Approach in Stage IIIA/N2 Non-Small Cell Lung Cancer

    Directory of Open Access Journals (Sweden)

    Branislav Jeremić

    2018-02-01

    Full Text Available While there are no established pretreatment predictive and prognostic factors in patients with stage IIIA/pN2 non-small cell lung cancer (NSCLC indicating a benefit to surgery as a part of trimodality approach, little is known about treatment-related predictive and prognostic factors in this setting. A literature search was conducted to identify possible treatment-related predictive and prognostic factors for patients for whom trimodality approach was reported on. Overall survival was the primary endpoint of this study. Of 30 identified studies, there were two phase II studies, 5 “prospective” studies, and 23 retrospective studies. No study was found which specifically looked at treatment-related predictive factors of improved outcomes in trimodality treatment. Of potential treatment-related prognostic factors, the least frequently analyzed factors among 30 available studies were overall pathologic stage after preoperative treatment and UICC downstaging. Evaluation of treatment response before surgery and by pathologic tumor stage after induction therapy were analyzed in slightly more than 40% of studies and found not to influence survival. More frequently studied factors—resection status, degree of tumor regression, and pathologic nodal stage after induction therapy as well as the most frequently studied factor, the treatment (in almost 75% studies—showed no discernible impact on survival, due to conflicting results. Currently, it is impossible to identify any treatment-related predictive or prognostic factors for selecting surgery in the treatment of patients with stage IIIA/pN2 NSCLC.

  2. Thermodynamic Modeling of Sr/TRU Removal

    International Nuclear Information System (INIS)

    Felmy, A.R.

    2000-01-01

    This report summarizes the development and application of a thermodynamic modeling capability designed to treat the Envelope C wastes containing organic complexants. A complete description of the model development is presented. In addition, the model was utilized to help gain insight into the chemical processes responsible for the observed levels of Sr, TRU, Fe, and Cr removal from the diluted feed from tank 241-AN-107 which had been treated with Sr and permanganate. Modeling results are presented for Sr, Nd(III)/Eu(III), Fe, Cr, Mn, and the major electrolyte components of the waste (i.e. NO 3 , NO 2 , F,...). On an overall basis the added Sr is predicted to precipitate as SrCO 3 (c) and the MnO 4 - reduced by the NO 2 - and precipitated as a Mn oxide. These effects result in only minor changes to the bulk electrolyte chemistry, specifically, decreases in NO 2 - and CO 3 2- , and increases in NO 3 - and OH - . All of these predictions are in agreement with the experimental observations. The modeling also indicates that the majority of the Sr, TRU's (or Nd(III)/Eu(III)) analogs, and Fe are tied up with the organic complexants. The Sr and permanganate additions are not predicted to effect these chelate complexes significantly owing to the precipitation of insoluble Mn oxides or SrCO 3 . These insoluble phases maintain low dissolved concentrations of Mn and Sr which do not affect any of the other components tied up with the complexants. It appears that the removal of the Fe and TRU'S during the treatment process is most likely as a result of adsorption or occlusion on/into the Mn oxides or SrCO 3 , not as direct displacement from the complexants into precipitates. Recommendations are made for further studies that are needed to help resolve these issues

  3. Electronic parameters of Sr2M2O7 (M = V, Nb, Ta) and Sr-O chemical bonding

    DEFF Research Database (Denmark)

    Atuchin, Victor V.; Grivel, Jean-Claude; Zhang, Zhaoming

    2010-01-01

    on the formation of the Sr-O bonds. The chemical bonding effects were considered on the basis of our XPS results for Sr2Nb2O7 and Sr2Ta2O7 and the previously published structural and XPS data for other Sr-oxide compounds. A new empirical relationship between Δ(O-Sr) and L(Sr-O) was obtained. Possible applications...

  4. Autoradiography of 90Sr in developing rats

    International Nuclear Information System (INIS)

    Olsen, I.; Jonsen, J.

    1979-01-01

    The distribution patterns of 90 Sr in five littermate, 8-day-old Wistar rats were studied by whole body autoradiography. Rats were killed 15 min, 1, 4, 24, and 72 h after a single intraperitoneal injection of the isotope. Immediately after administration, 90 Sr was distributed throughout most of the soft tissues of the body. The soft tissue deposits had practically disappeared after 4 h. In the hard tissues of the body 90 Sr accumulated up to 24-72 h. Fifteen minutes after injection the uptake of 90 Sr in the enamel of the teeth was highest in the occlusal and incisal regions. 90 Sr gradually accumulated throughout the enamel and after 72 h its distribution in this layer was fairly uniform. Immediately after injection a narrow zone of radioactivity appeared in the dentin near the pulp. This zone broadened with time towards the dentinoenamel junction and included the intire dentin layer 72 h after injection. Initially, the uptake of 90 Sr was higher in the dentin than in the enamel, particularly in the cervical areas of the crown. This difference became less apparent with time. There was good correlation between the uptake in the teeth and bones, supporting the use of teeth as indicators of the 90 Sr body burden. (author)

  5. Maxdose-SR and popdose-SR routine release atmospheric dose models used at SRS

    Energy Technology Data Exchange (ETDEWEB)

    Jannik, G. T. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Trimor, P. P. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2017-07-28

    MAXDOSE-SR and POPDOSE-SR are used to calculate dose to the offsite Reference Person and to the surrounding Savannah River Site (SRS) population respectively following routine releases of atmospheric radioactivity. These models are currently accessed through the Dose Model Version 2014 graphical user interface (GUI). MAXDOSE-SR and POPDOSE-SR are personal computer (PC) versions of MAXIGASP and POPGASP, which both resided on the SRS IBM Mainframe. These two codes follow U.S. Nuclear Regulatory Commission (USNRC) Regulatory Guides 1.109 and 1.111 (1977a, 1977b). The basis for MAXDOSE-SR and POPDOSE-SR are USNRC developed codes XOQDOQ (Sagendorf et. al 1982) and GASPAR (Eckerman et. al 1980). Both of these codes have previously been verified for use at SRS (Simpkins 1999 and 2000). The revisions incorporated into MAXDOSE-SR and POPDOSE-SR Version 2014 (hereafter referred to as MAXDOSE-SR and POPDOSE-SR unless otherwise noted) were made per Computer Program Modification Tracker (CPMT) number Q-CMT-A-00016 (Appendix D). Version 2014 was verified for use at SRS in Dixon (2014).

  6. Effect of new and conventional technological processes on the terroir marker 87Sr/86Sr

    Directory of Open Access Journals (Sweden)

    Catarino Sofia

    2016-01-01

    Full Text Available Aiming to use the strontium isotopic ratio 87Sr/86Sr for traceability and authentication of wine, it is crucial to understand the impacts of anthropogenic factor and technological processes on this parameter. In this study the effect of two technologies: nanofiltration (NF, applied for wine dealcoholisation (1, and ageing with oak wood staves (2, on 87Sr/86Sr ratio of wines from Portuguese Designations of Origin (DO, was assessed. Control wines, NF processed wines and wooden aged wines were evaluated for chemical composition, multi-elemental composition and 87Sr/86Sr ratio by Q-ICP-MS. Regarding NF experiments, high rejections to mineral elements, including heavy metals, were observed. Bearing in mind the several roles played by these elements in wine, this knowledge is of strategic importance in order to guarantee that NF process does not adversely affect product quality. Concerning wood ageing experiment, results indicate the influence of this technological process on metal physical-chemical stability. In the experimental conditions of this study, no significant effect of NF process and wood ageing on 87Sr/86Sr ratio was observed, suggesting that the application of these technologies in wine production is not a limitative factor for the use of 87Sr/86Sr ratio as a geographical origin marker.

  7. Report on nuclear energy in SR Slovenia

    International Nuclear Information System (INIS)

    1987-01-01

    Currently Yugoslavia has one 632 MWe nuclear power plant (NPP) of PWR design, located at Krsko in the Socialist Republic (SR) of Slovenia. Krsko NPP, which is a two-loop plant, started power operation in 1981. In general, reactor safety activities in the SR of Slovenia are mostly related to upgrading the safety of our Krsko NPP and to developing capabilities for use in future units. This report presents the nuclear safety related legislation and organization of the corresponding regulatory body, and the activities related to nuclear safety of the participating organizations in the SR of Slovenia in 1987.

  8. Safety and preliminary efficacy of one month glycoprotein IIb/IIIa inhibition with lefradafiban in patients with acute coronary syndromes without ST-elevation; a phase II study.

    Science.gov (United States)

    Akkerhuis, K M; Neuhaus, K L; Wilcox, R G; Vahanian, A; Boland, J L; Hoffmann, J; Baardman, T; Nehmiz, G; Roth, U; Klootwijk, A P; Deckers, J W; Simoons, M L

    2000-12-01

    Oral glycoprotein IIb/IIIa inhibitors might enhance the early benefit of an intravenous agent and prevent subsequent cardiac events in patients with acute coronary syndromes. We assessed the safety and preliminary efficacy of 1 month treatment with three dose levels of the oral GP IIb/IIIa blocker lefradafiban in patients with unstable angina or myocardial infarction without persistent ST elevation. The Fibrinogen Receptor Occupancy STudy (FROST) was designed as a dose-escalation trial with 20, 30 and 45 mg lefradafiban t.i.d. or placebo. Five hundred and thirty-one patients were randomized in a 3:1 ratio to lefradafiban or placebo in a double-blind manner. Efficacy was assessed by the incidence of death, myocardial infarction, coronary revascularization and recurrent angina. Safety was evaluated by the occurrence of bleeding classified according to the TIMI criteria and by measuring clinical laboratory parameters. There was a trend towards a reduction in cardiac events with lefradafiban 30 mg when compared with placebo and lefradafiban 20 mg. The benefit was particularly apparent in patients with a positive (> or = O.1 ng. ml(-1)) troponin I test at baseline and less so in those with a negative test result. In patients receiving lefradafiban, the cardiac event rate decreased with increasing minimal levels of fibrinogen receptor occupancy. There was a dose-dependent increase in the incidence of bleeding: the composite of major or minor bleeding occurred in 1% of placebo patients, 5% of patients receiving lefradafiban 20 mg and in 7% of patients receiving 30 mg, with an excessive risk (15%) in the 45 mg group which resulted in early discontinuation of this dose level. Gingival and arterial or venous puncture site bleedings were most common and accounted for more than 60% of all haemorrhagic events. There was an increased incidence of neutropenia (neutrophils <1. 5 x 10(9)/l) in the lefradafiban groups (5.2% vs 1.5% in the placebo group), which did not result from

  9. Addition to the analysis of the Sr VI and Sr VII spectra

    International Nuclear Information System (INIS)

    Wyart, J.F.

    1989-01-01

    Fifty-six lines of multicharged strontium are measured with an improved wavelength accuracy, or interpreted for the first time. They are 4p-4s, 4p-5s and 4p-4d transitions in Sr VII and 4p-5s transitions in Sr VI. The revision of the singlet-triplet connection in Sr VII is supported by theoretical survey of the ground configuration in Ge-like ions. (orig.)

  10. Crizotinib in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Removed by Surgery and ALK Fusion Mutations (An ALCHEMIST Treatment Trial)

    Science.gov (United States)

    2017-12-07

    ALK Gene Rearrangement; ALK Gene Translocation; ALK Positive; Stage IB Non-Small Cell Lung Carcinoma AJCC v7; Stage II Non-Small Cell Lung Cancer AJCC v7; Stage IIA Non-Small Cell Lung Carcinoma AJCC v7; Stage IIB Non-Small Cell Lung Carcinoma AJCC v7; Stage IIIA Non-Small Cell Lung Cancer AJCC v7

  11. Genotypes of hepatitis a virus in Turkey: first report and clinical profile of children infected with sub-genotypes IA and IIIA.

    Science.gov (United States)

    Yilmaz, Huseyin; Karakullukcu, Asiye; Turan, Nuri; Cizmecigil, Utku Y; Yilmaz, Aysun; Ozkul, Ayse A; Aydin, Ozge; Gunduz, Alper; Mete, Mahmut; Zeyrek, Fadile Y; Kirazoglu, Taner T; Richt, Juergen A; Kocazeybek, Bekir

    2017-08-11

    Hepatitis A virus (HAV) is a food and water-borne virus causing clinical (mainly hepatitis) and subclinical disease in humans. It is important to characterize circulating strains of HAV in order to prevent HAV infections using efficacious vaccines. The aim of this study was the detection and characterization of the circulating strains of HAV in Turkey by performing serology, RT-PCR, sequencing and phylogenetic analysis. In this study, 355 HAV suspected cases were analysed by ELISA for the presence of antibodies to HAV. RNA was extracted from 54 HAV IgM positive human sera. None of the suspect cases were vaccinated against HAV and they never received blood transfusions. Samples found positive by RT-PCR using primers targeting the VP1/VP2A junction and VP1/VP3 capsid region of HAV, were subjected to sequencing and phylogenetic analyses. IgM type antibodies to HAV were detected in 54 patients. Twenty one of them were students. The age of IgM positive cases was between 3 and 60 years. IgM positivity differed in age groups and was higher in the age group 3 to 10 years. Phylogenetic analysis showed that the majority of HAV strains detected in this study belong to the "HAV 1B" cluster. In addition, the HAV sub-genotypes IA (KT874461.1) and IIIA (KT222963.1) were found in 2 children. These sub-genotypes were not previously reported in Turkey. The child who carried sub-genotype IIIA travelled to Afghanistan and presented with abdominal pain, icterus and vomitus. He was positive for anti-HAV IgM and IgG but negative for hepatitis B and C. Liver enzymes like aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma-glutamyl transferase and lactate dehydrogenase were severely elevated. Bilirubin levels were also increased. White blood cells, neutrophils and hemoglobin were decreased while lymphocytes and monocytes were increased. Similar clinical signs and laboratory findings were reported for the child infected with sub-genotype IA but aspartate

  12. CHARACTERIZATION OF THE PARTIALLY PURIFIED PLANTARCIN SR18 PRODUCED BY LACTOBACILLUS PLANTARUM SR18

    Directory of Open Access Journals (Sweden)

    Wagih El-Shouny

    2013-04-01

    Full Text Available The bacteriocin bound to the cells and that secreted into the culture filtrate of Lactobacillus plantarum SR18 were precipitated by 75% ammomium sulphate, dialysed and further purified by Gel filtration on Sephadex G-100. Bacteriocins were purified from proteins bound to the cell of L. plantarum SR18 (plantarcin SR18 a and culture filtrate proteins (plantarcin SR18 b, respectively. The SDS-PAGE of partially purified Plantarcin SR18a showed a molecular weight of 3.5 KDa. While, plantarcin SR18 b had a molecular weight of 10.3 KDa. The antibacterial activity of the tested plantarcin SR18 preparations suffered no measurable loss after 45 min at 80ºC. Whereas, At 100ºC, significant decrease in the activity of bacteriocin preparations (60- 80 % took place by the end of 45 min. At pH ranged from 5-8, the activity of the plantarcin SR18 preparations suffered no measurable loss. Dissociating agents significantly affected the bacteriocin activity. Thus, tween 80 and mercaptoethanol increased the activity of bacteriocin preparations to 1.2-1.4 fold. Sodium dodecyl sulphate (SDS increased the activity of the tested bacteriocin preparations by about 20%.The lowest residual activity (60% was recorded after treatment with Triton X100 for 45 min. Protease completely inhibited the activities of all forms of plantarcin SR18 after 45 min at 37ºC.

  13. Metastable honeycomb SrTiO3/SrIrO3 heterostructures

    International Nuclear Information System (INIS)

    Anderson, T. J.; Ryu, S.; Podkaminer, J. P.; Ma, Y.; Eom, C. B.; Zhou, H.; Xie, L.; Irwin, J.; Rzchowski, M. S.; Pan, X. Q.

    2016-01-01

    Recent theory predictions of exotic band topologies in (111) honeycomb perovskite SrIrO 3 layers sandwiched between SrTiO 3 have garnered much attention in the condensed matter physics and materials communities. However, perovskite SrIrO 3 film growth in the (111) direction remains unreported, as efforts to synthesize pure SrIrO 3 on (111) perovskite substrates have yielded films with monoclinic symmetry rather than the perovskite structure required by theory predictions. In this study, we report the synthesis of ultra-thin metastable perovskite SrIrO 3 films capped with SrTiO 3 grown on (111) SrTiO 3 substrates by pulsed laser deposition. The atomic structure of the ultra-thin films was examined with scanning transmission electron microscopy (STEM), which suggests a perovskite layering distinct from the bulk SrIrO 3 monoclinic phase. In-plane 3-fold symmetry for the entire heterostructure was confirmed using synchrotron surface X-ray diffraction to measure symmetry equivalent crystal truncation rods. Our findings demonstrate the ability to stabilize (111) honeycomb perovskite SrIrO 3 , which provides an experimental avenue to probe the phenomena predicted for this material system.

  14. Prevalence and Predictors of Neoadjuvant Therapy for Stage IIIA Non-Small Cell Lung Cancer in the National Cancer Database: Importance of Socioeconomic Status and Treating Institution

    International Nuclear Information System (INIS)

    Sher, David J.; Liptay, Michael J.; Fidler, Mary Jo

    2014-01-01

    Purpose: The optimal locoregional therapy for stage IIIA non-small cell lung cancer (NSCLC) is controversial, with definitive chemoradiation therapy (CRT) and neoadjuvant therapy followed by surgery (NT-S) serving as competing strategies. In this study, we used the National Cancer Database to determine the prevalence and predictors of NT in a large, modern cohort of patients. Methods and Materials: Patients with stage IIIA NSCLC treated with CRT or NT-S between 2003 and 2010 at programs accredited by the Commission on Cancer were included. Predictors were categorized as clinical, time/geographic, socioeconomic, and institutional. In accord with the National Cancer Database, institutions were classified as academic/research program and as comprehensive and noncomprehensive community cancer centers. Logistic regression and random effects multilevel logistic regression were performed for univariable and multivariable analyses, respectively. Results: The cohort consisted of 18,581 patients, 3,087 (16.6%) of whom underwent NT-S (10.6% induction CRT, 6% induction chemotherapy). The prevalence of NT-S was constant over time, but there were significant relative 31% and 30% decreases in pneumonectomy and right-sided pneumonectomy, respectively, over time (P trend <.02). In addition to younger age, lower T stage, and favorable comorbidity score, indicators of higher socioeconomic status were strong independent predictors of NT-S, including white race, higher income, and private/managed insurance. The type of institution (academic/research program vs comprehensive or noncomprehensive community cancer centers, odds ratio 1.54 and 2.08, respectively) strongly predicted NT-S, but treatment volume did not. Conclusions: Neoadjuvant therapy followed by surgery was an uncommon treatment approach in Commission on Cancer programs, and the prevalence of postinduction pneumonectomy decreased over time. Higher socioeconomic status and treatment at academic institutions were significant

  15. Analytical microscopy observations of rat enterocytes after oral administration of soluble salts of lanthanides, actinides and elements of group III-A of the periodic chart.

    Science.gov (United States)

    Floren, C; Tekaya, L; Escaig, F; Labejof, L; Mouthon, G; Galle, P

    2001-05-01

    The behavior in the intestinal barrier of nine elements (three of the group III-A, four lanthanides and two actinides), absorbed as soluble salts, has been studied by two microanalytical methods: electron probe X-ray micro analysis (EPMA) and secondary ion mass spectrometry (SIMS). It has been shown that the three elements of group III-A, aluminium, gallium and indium; and the four lanthanides, lanthanum, cerium, europium and thulium, are selectively concentrated and precipitated as non-soluble form in enterocytes of proximal part of the intestinal tract. SIMS microscopy has shown that these elements are concentrated as a number of submicroscopic precipitates, most of them localized in the apical part of the duodenum enterocytes, where they are observed from one hour to 48 hr after a single intragastric administration. No precipitate is observed after three days. It is suggested that this mechanism of local concentration limits the diffusion of these elements through the digestive barrier, some of them being toxic and none of them having a recognized physiological role. Additionally, the precipitation in duodenal enterocytes, the life time of which is on the order of 2-3 days, allows the elements absorbed as soluble form to be eliminated as a non-soluble form in the digestive lumen along with the desquamation of the apoptotic enterocytes. The intracytoplasmic localization of the precipitates are supposed to be the lysosomes although no direct evidence could be given here due to the very small sizes of the lysosomes of enterocytes. The same results were not observed with the two studied actinides. After administration of thorium, only some very sparse microprecipitates could be observed in intestinal mucosa and, after administration of uranium, no precipitates were observed with the exception of some in the conjunctive part of the duodenal villi.

  16. The three-dimensional solution structure of mini-M conotoxin BtIIIA reveals a disconnection between disulfide connectivity and peptide fold.

    Science.gov (United States)

    Akcan, Muharrem; Cao, Ying; Chongxu, Fan; Craik, David J

    2013-06-15

    Conotoxins are bioactive peptides from the venoms of marine snails and have been divided into several superfamilies based on homologies in their precursor sequences. The M-superfamily conotoxins can be further divided into five branches based on the number of residues in the third loop of the peptide sequence. Recently two M-1 branch conotoxins (tx3a and mr3e) with a C1-C5, C2-C4, C3-C6 disulfide connectivity and one M-2 branch conotoxin (mr3a) with a C1-C6, C2-C4, C3-C5 disulfide connectivity were described. Here we report the disulfide connectivity, chemical synthesis and the three-dimensional NMR structure of the novel 14-residue conotoxin BtIIIA, extracted from the venom of Conus betulinus. It has the same disulfide connectivity as mr3a, which puts it in the M-2 branch conotoxins but has a distinctly different structure from other M-2 branch conotoxins. 105 NOE distance restraints and seven dihedral angle restraints were used for the structure calculations. The three-dimensional structure was determined with CYANA based on torsion angle dynamics and refinement in a water solvent box was carried out with CNS. Fifty structures were calculated and the 20 lowest energy structures superimposed with a RMSD of 0.49±0.16 Å. Even though it has the M-2 branch disulfide connectivity, BtIIIA was found to have a 'flying bird' backbone motif depiction that is found in the M-1 branch conotoxin mr3e. This study shows that conotoxins with the same cysteine framework can have different disulfide connectivities and different peptide folds. Copyright © 2013 Elsevier Ltd. All rights reserved.

  17. Diagnostic and co-dominant PCR markers for wheat stem rust resistance genes Sr25 and Sr26.

    Science.gov (United States)

    Liu, Sixin; Yu, Long-Xi; Singh, Ravi P; Jin, Yue; Sorrells, Mark E; Anderson, James A

    2010-02-01

    Wheat stem rust, caused by Puccinia graminis f. sp. tritici, is one of the most destructive diseases of wheat. A new race of the pathogen named TTKSK (syn. Ug99) and its derivatives detected in East Africa are virulent to many designated and undesignated stem rust resistance genes. The emergence and spread of those races pose an imminent threat to wheat production worldwide. Genes Sr25 and Sr26 transferred into wheat from Thinopyrum ponticum are effective against these new races. DNA markers for Sr25 and Sr26 are needed to pyramid both genes into adapted germplasm. The previously published dominant markers Gb for Sr25 and Sr26#43 for Sr26 were validated with eight wheat lines with or without Sr25 or Sr26. We tested six published STS (sequence tagged site) markers amplifying diagnostic bands of Th. ponticum. Marker BF145935 consistently amplified well and can be used as a co-dominant marker for Sr25. Among 16 STS markers developed from wheat ESTs mapped to deletion bin 6AL8-0.90-1.00, none was co-dominant for tagging Sr26. However, five 6A-specific markers were identified. Multiplex PCR with marker Sr26#43 and 6A-specific marker BE518379 can be used as a co-dominant marker for Sr26. The co-dominant markers for Sr25 and Sr26 were validated with 37 lines with known stem rust resistance genes. A diverse set of germplasm consisting 170 lines from CIMMYT, China, USA and other counties were screened with the co-dominant markers for Sr25 and Sr26. Five lines with the diagnostic fragment for Sr25 were identified, and they all have 'Wheatear' in their pedigrees, which is known to carry Sr25. None of the 170 lines tested had Sr26, as expected.

  18. Construction of the seawater 87Sr/86Sr curve for the Cenozoic and Cretaceous: supporting data

    International Nuclear Information System (INIS)

    Koepnick, R.B.; Burke, W.H.; Denison, R.E.; Hetherington, E.A.; Nelson, H.F.; Otto, J.B.; Waite, L.E.

    1985-01-01

    We present the data used to construct the Cenozoic and Cretaceous portion of the Phanerozoic curve of seawater 87 Sr/ 86 Sr that had been given in summary form by W.H. Burke and coworkers. All Cenozoic samples (128) and 22 Cretaceous samples are foram-nannofossil oozes and limestones from DSDP cores distributed among 13 sites in the Atlantic, Pacific and Indian Oceans, and the Caribbean Sea. Non-DSDP Cretaceous samples (126) include limestone, anhydrite and phosphate samples from North America, Europe and Asia. Determination of the 87 Sr/ 86 Sr value of seawater at particular times in the past is based on comparison of ratios derived from coeval marine samples from widely separated geographic areas. The general configuration of the Cenozoic and Cretaceous curve appears to be strongly influenced by the history of plate interactions and sea-floor spreading. Specific rises and falls in the 87 Sr/ 86 Sr of seawater, however, may be caused by a variety of factors such as variation in lithologic composition of the crust exposed to weathering, configuration and topographic relief of continents, volcanic activity, rate of sea-floor spreading, extent of continental inundation by epeiric seas, and variations in both climate and paleo-oceanographic conditions. Many or all of these factors are probably related to global tectonic processes, yet their combined effect on the temporal variation of seawater 87 Sr/ 86 Sr can complicate a direct plate-tectonic interpretation for portions of the seawater curve. (Auth.)

  19. Physical and electrical properties of SrTiO3 and SrZrO3

    Directory of Open Access Journals (Sweden)

    Muhamad Norhizatol Fashren

    2017-01-01

    Full Text Available Perovskite type oxide strontium titanate (SrTiO3 and strontium zirconate (SrZrO3 ceramic powder has been synthesized using conventional solid state reaction method. The powders were mixed and ground undergone calcinations at 1400°C for 12 h and sintered at 1550°C for 5h. X-ray Diffraction exposes physical properties SrTiO3 which exhibit cubic phase (space group: pm-3m at room temperature meanwhile SrZrO3 has Orthorhombic phase (space group: pnma. The electrical properties such as dielectric constant (εr, dielectric loss (tan δ, and conductivity (σ were studied in variation temperature and frequency. High dielectric constant of SrTiO3 and SrZrO3 were observed at 10 kHz for both samples about 240 and 21 respectively at room temperature. The dielectric loss of SrTiO3 and SrZrO3 is very low loss value approximately 0.00076 and 0.67512 indicates very good dielectric.

  20. The Determination of 11 B/ 10 B and 87 Sr/ 86 Sr Isotope Ratios by ...

    African Journals Online (AJOL)

    Both wine and soil samples were prepared using microwave-assisted digestion followed by the isolation of boron and strontium from the sample matrix through element-specific ion exchange. Isotope ratio measurements with good precision, ~0.1 % RSD, for both boron and strontium have been obtained. The 87Sr/86Sr ...

  1. Removal of Sr-90 from ground water

    International Nuclear Information System (INIS)

    Ostapczuk, P.; Hobig, J.; Hill, P.; Hille, R.

    2003-01-01

    Full text: Results of a preliminary study for clean-up of the water from a ground water contaminated by Sr-90 using two different ion-exchange resins and co-precipitation are presented. The analytical data for the studied water is shown. The measured Sr-90 content is higher than the limit for water in Germany. Three methods of removal of Sr-90 from ground-water have been compared. DOWEX C-75 NG, H-form is a strong acid cation exchange resin and highly selective for Cs and Co. Our experiments have demonstrated that these resins is also selective for Sr. It was possible to clean-up 550 ml of contaminated ground water with only 1 g of these resins. The concentration of Sr-90 after clean-up is below 0.02 Bq/l. Disadvantage of these procedure was the change of pH of water to 2.5 after clean-up and high price (if the resin is not regenerated). CARBION is a product manufactured by careful phosphorylation and carabamidation of cellulose fibre according to a patented process with ion-exchanging characteristics. In opposite to DOWEX C-75 NG (H) this product is biodegradable. Obtained results have demonstrated that using CARBION it is also possible to clean-up the water sample from Sr-90 below the detection limit of 0.02 Bq/l. The ion-exchange process is not so quick and need significant more time than in case of the use of DOWEX C-75 NG. CARBION does not change the natural pH of water. The calculated price needed for the amount of these resin necessary for cleanup the same volume of contaminated water was about 2 times higher than in case of DOWEX C-75 NG. In the third method the natural high pH level of the studied water sample (pH = 7.88) and the high natural concentration of Ca, Mg and Sr ions make it also possible to co-participate Sr-90 with phosphates. After addition of appropriate amounts of Na 2 HPO 4 it was possible to reduce the Sr-90 content to about 1.3 Bq/l which is below the required limit. The advantages of these methods are simplicity, short time and low

  2. Facile Synthesis of SrCO3-Sr(OH)2/PPy Nanocomposite with Enhanced Photocatalytic Activity under Visible Light

    Science.gov (United States)

    Márquez-Herrera, Alfredo; Ovando-Medina, Victor Manuel; Castillo-Reyes, Blanca Estela; Zapata-Torres, Martin; Meléndez-Lira, Miguel; González-Castañeda, Jaquelina

    2016-01-01

    Pyrrole monomer was chemically polymerized onto SrCO3-Sr(OH)2 powders to obtain SrCO3-Sr(OH)2/polypyrrole nanocomposite to be used as a candidate for photocatalytic degradation of methylene blue dye (MB). The material was characterized by Fourier transform infrared (FTIR) spectroscopy, UV/Vis spectroscopy, and X-ray diffraction (XRD). It was observed from transmission electronic microscopy (TEM) analysis that the reported synthesis route allows the production of SrCO3-Sr(OH)2 nanoparticles with particle size below 100 nm which were embedded within a semiconducting polypyrrole matrix (PPy). The SrCO3-Sr(OH)2 and SrCO3-Sr(OH)2/PPy nanocomposites were tested in the photodegradation of MB dye under visible light irradiation. Also, the effects of MB dye initial concentration and the catalyst load on photodegradation efficiency were studied and discussed. Under the same conditions, the efficiency of photodegradation of MB employing the SrCO3-Sr(OH)2/PPy nanocomposite increases as compared with that obtained employing the SrCO3-Sr(OH)2 nanocomposite. PMID:28787830

  3. Facile Synthesis of SrCO3-Sr(OH2/PPy Nanocomposite with Enhanced Photocatalytic Activity under Visible Light

    Directory of Open Access Journals (Sweden)

    Alfredo Márquez-Herrera

    2016-01-01

    Full Text Available Pyrrole monomer was chemically polymerized onto SrCO3-Sr(OH2 powders to obtain SrCO3-Sr(OH2/polypyrrole nanocomposite to be used as a candidate for photocatalytic degradation of methylene blue dye (MB. The material was characterized by Fourier transform infrared (FTIR spectroscopy, UV/Vis spectroscopy, and X-ray diffraction (XRD. It was observed from transmission electronic microscopy (TEM analysis that the reported synthesis route allows the production of SrCO3-Sr(OH2 nanoparticles with particle size below 100 nm which were embedded within a semiconducting polypyrrole matrix (PPy. The SrCO3-Sr(OH2 and SrCO3-Sr(OH2/PPy nanocomposites were tested in the photodegradation of MB dye under visible light irradiation. Also, the effects of MB dye initial concentration and the catalyst load on photodegradation efficiency were studied and discussed. Under the same conditions, the efficiency of photodegradation of MB employing the SrCO3-Sr(OH2/PPy nanocomposite increases as compared with that obtained employing the SrCO3-Sr(OH2 nanocomposite.

  4. C, Sr and Sr isotopic composition on probable vendian- tommotian carbonate sequences in Nw Argentina

    International Nuclear Information System (INIS)

    Sial, A. N.; Ferreira, V.P; Toselli, A.J.; Acenolaza, F.G; Pimentel, M.M; Parada, M.A; Alonso, R.N

    2001-01-01

    C-isotope stratigraphy is one of the most powerfool tools in Precambrian chronostratigraphy, especially when sediments lack recognizable animal fossils. The δ 13 C secular variation curves for marine carbonates in the Neoproterozoic-Cambrian interval show strong positive-negative excursions, several of them interpreted as the stratigraphic position of ancient ice ages (Hoffman et al. 1998). The Sr isotope composition of the seawater for this age interval is characterized by a continuous increase of 87 Sr/ 86 Sr that is interrupted, several times, by sharp rises, which represent important changes in the Earth history (Montanez et al. 2000). Only limited data on the behavior of C and Sr isotopes in carbonates are available in South America. We examine here carbonate sequences from the Argentine Precordillera, San Juan province, and from other carbonate sequences in NW Argentina that could be, potentially, proxies for the Precambrian-Cambrian transition. We have studied their δ 13 C and 87 Sr/ 86 Sr chemostratigraphy and compare it to global C and Sr isotope secular variation curves for this time span. This study aims to improve the relatively coarse stratigraphic resolution provided only by the study of the fossil record in some of the carbonate successions under consideration (au)

  5. SR 97 - Identification and structuring of process

    International Nuclear Information System (INIS)

    Pers, K.; Skagius, K.; Soedergren, S.; Wiborgh, M.; Hedin, A.; Moren, L.; Sellin, P.; Stroem, A.; Pusch, R.; Bruno, J.

    1999-12-01

    This report documents work conducted in recent years to identify processes and interactions of importance to the evaluation of long-term safety of a KBS 3 type deep repository for spent nuclear fuel. Previous, partly undocumented work regarding interaction matrices is described as well as the THMC diagrams that have been used in the safety assessment SR 97. The coupling between the two sources of information is documented in a database. In the same database, the interaction matrices are briefly documented, while the processes in the THMC diagrams are more thoroughly documented in a special so called Process Report, which forms an important supporting document for SR 97

  6. Geochronological synthesis of Bahia state and the crustal evolution, based in evolution diagram of Sr and initial rate of Sr87/Sr86

    International Nuclear Information System (INIS)

    Sato, K.

    1986-01-01

    The crustal evolution of the ancient terrains of the State of Bahia, Brazil, is attempted with the aid of Sr isotopic results as natural tracers. Some Nd and Pb isotopic data are also available, and support the main conclusions based on Sr evolution diagrams. The analysis of the Sr evolution diagrams shows that the Archean Terrains are mainly formed by accretion from mantle-derived material, but crustal reworking is indicated by the high initial 87 Sr/ 86 Sr value of the Jequie Complex. The Transamazonian mobile belt include both types of materials, but the 87 Sr/ 86 Sr value, generally lower than those of the Jequie Complex, markes improbable a direct derivation. During Middle and Late Proterozoic, the continental crust was already well consolidated, and reworking of crustal material predominated within the Espinhaco and Brasiliano folded systems [pt

  7. Structural and compositional characterization of synthetic (Ca,Sr)-tremolite and (Ca,Sr)-diopside solid solutions

    Science.gov (United States)

    Gottschalk, M.; Najorka, J.; Andrut, M.

    Tremolite (CaxSr1-x)2Mg5[Si8O22/(OH)2] and diopside (CaxSr1-x)Mg[Si2O6] solid solutions have been synthesized hydrothermally in equilibrium with a 1 molar (Ca,Sr)Cl2 aqueous solution at 750°C and 200 MPa. The solid run products have been investigated by optical, electron scanning and high resolution transmission electron microscopy, electron microprobe, X-ray-powder diffraction and Fourier-transform infrared spectroscopy. The synthesized (Ca,Sr)-tremolites are up to 2000 µm long and 30 µm wide, the (Ca,Sr)-diopsides are up to 150 µm long and 20 µm wide. In most runs the tremolites and diopsides are well ordered and chain multiplicity faults are rare. Nearly pure Sr-tremolite (tr0.02Sr-tr0.98) and Sr-diopside (di0.01Sr-di0.99) have been synthesized. A continuous solid solution series, i.e. complete substitution of Sr2+ for Ca2+ on M4-sites exists for (Ca,Sr)-tremolite. Total substitution of Sr2+ for Ca2+ on M2-sites can be assumed for (Ca,Sr)-diopsides. For (Ca,Sr)-tremolites the lattice parameters a, b and β are linear functions of composition and increase with Sr-content whereas c is constant. For the diopside series all 4 lattice parameters are a linear function of composition; a, b, c increase and β decreases with rising Sr-content. The unit cell volume for tremolite increases 3.47% from 906.68 Å3 for tremolite to 938.21 Å3 for Sr-tremolite. For diopside the unit cell volume increases 4.87 % from 439.91 Å3 for diopside to 461.30 Å3 for Sr-diopside. The observed splitting of the OH stretching band in tremolite is caused by different configurations of the next nearest neighbors (multi mode behavior). Resolved single bands can be attributed to the following configurations on the M4-sites: SrSr, SrCa, CaCa and CaMg. The peak positions of these 4 absorption bands are a linear function of composition. They are shifted to lower wavenumbers with increasing Sr-content. No absorption band due to the SrMg configuration on the M4-site is observed. This indicates

  8. FEP report for the safety assessment SR-Site

    International Nuclear Information System (INIS)

    2010-12-01

    This report documents the analysis and processing of features, events and processes, FEPs, that has been carried out within the safety assessment SR-Site, and forms an important part of the reporting of the project. The main part of the work was conducted within the earlier safety assessment SR-Can, which was a preparatory stage for the SR-Site assessment. The overall objective of the FEP analysis and processing in both SR-Can and SR-Site included development of a database of features, events and processes, an SKB FEP database, in a format that facilitates both a systematic analysis of FEPs and documentation of that FEP analysis, as well as facilitating revisions and updates to be made in connection with new safety assessments. The primary objective in SR-Site was to establish an SR-Site FEP catalogue within the framework of the SKB FEP database. This FEP catalogue was required to contain all FEPs that needed to be handled in SR-Site and is an update of the corresponding SR-Can FEP catalogue that was established for the SR-Can assessment. The starting point for the handling of FEPs in SR-Site was the SR-Can version of the SKB FEP database and associated SR-Can reports. The SR-Can version of the SKB FEP database includes the SR-Can FEP catalogue, as well as the sources for the identification of FEPs in SR-Can, namely the SR 97 processes and variables, Project FEPs in the NEA International FEP database version 1.2 and matrix interactions in the Interaction matrices developed for a deep repository of the KBS-3 type. Since the completion of the FEP work within SR-Can, an updated electronic version, version 2.1, of the NEA FEP database has become available. Compared with version 1.2 of the NEA FEP database, version 2.1 contains FEPs from two more projects. As part of SR-Site, all new Project FEPs in version 2.1 of the NEA FEP database have been mapped according to the methodology adopted in SR-Can resulting in an SR-Site version of the SKB FEP database. The SKB FEP

  9. FEP report for the safety assessment SR-Site

    Energy Technology Data Exchange (ETDEWEB)

    2010-12-15

    This report documents the analysis and processing of features, events and processes, FEPs, that has been carried out within the safety assessment SR-Site, and forms an important part of the reporting of the project. The main part of the work was conducted within the earlier safety assessment SR-Can, which was a preparatory stage for the SR-Site assessment. The overall objective of the FEP analysis and processing in both SR-Can and SR-Site included development of a database of features, events and processes, an SKB FEP database, in a format that facilitates both a systematic analysis of FEPs and documentation of that FEP analysis, as well as facilitating revisions and updates to be made in connection with new safety assessments. The primary objective in SR-Site was to establish an SR-Site FEP catalogue within the framework of the SKB FEP database. This FEP catalogue was required to contain all FEPs that needed to be handled in SR-Site and is an update of the corresponding SR-Can FEP catalogue that was established for the SR-Can assessment. The starting point for the handling of FEPs in SR-Site was the SR-Can version of the SKB FEP database and associated SR-Can reports. The SR-Can version of the SKB FEP database includes the SR-Can FEP catalogue, as well as the sources for the identification of FEPs in SR-Can, namely the SR 97 processes and variables, Project FEPs in the NEA International FEP database version 1.2 and matrix interactions in the Interaction matrices developed for a deep repository of the KBS-3 type. Since the completion of the FEP work within SR-Can, an updated electronic version, version 2.1, of the NEA FEP database has become available. Compared with version 1.2 of the NEA FEP database, version 2.1 contains FEPs from two more projects. As part of SR-Site, all new Project FEPs in version 2.1 of the NEA FEP database have been mapped according to the methodology adopted in SR-Can resulting in an SR-Site version of the SKB FEP database. The SKB FEP

  10. A high 87Sr 86Sr mantle source for low alkali tholeiite, northern Great Basin

    Science.gov (United States)

    Mark, R.K.; Lee, Hu C.; Bowman, H.R.; Asaro, F.; McKee, E.H.; Coats, R.R.

    1975-01-01

    Olivine tholeiites, the youngest Tertiary units (about 8-11 m.y. old) at five widely spaced localities in northeastern Nevada, are geologically related to the basalts of the Snake River Plain, Idaho, to the north and are similar in major element and alkali chemistry to mid-ocean ridge basalts (MORB) and island arc tholeiites. The measured K (1250-3350 ppm), Rb (1??9-6??2 ppm) and Sr (140-240 ppm) concentrations overlap the range reported for MORB. Three of the five samples have low, unfractionated rare earth element (REE) patterns, the other two show moderate light-REE enrichment. Barium concentration is high and variable (100-780 ppm) and does not correlate with the other LIL elements. The rocks have 87Sr/86Sr = 0??7052-0??7076, considerably higher than MORB (~0??702-0??703). These samples are chemically distinct (i.e. less alkalic) from the olivine tholeiites from the adjacent Snake River Plain, but their Sr isotopic compositions are similar. They contain Sr that is distinctly more radiogenic than the basalts from the adjacent Great Basin. About 10 b.y. would be required for the mean measured Rb/Sr (~ 0??02) of these samples to generate, in a closed system, the radiogenic Sr they contain. The low alkali content of these basalts makes crustal contamination an unlikely mechanism. If the magma is uncontaminated, the time-averaged Rb/Sr of the source material must have been ~0??04. A significant decrease in Rb/Sr of the source material (a factor 2??) thus most probably occurred in the relatively recent (1??09 yr) past. Such a decrease of Rb/Sr in the mantle could accompany alkali depletion produced by an episode of partial melting and magma extraction. In contrast, low 87Sr 86Sr ratios indicate that the source material of the mid-ocean ridge basalts may have been depleted early in the Earth's history. ?? 1975.

  11. Investigation of a dynamic seawater intrusion event using strontium isotopes (87Sr/86Sr)

    DEFF Research Database (Denmark)

    Jørgensen, Niels Oluf; Andersen, Martin S.; Engesgaard, Peter Knudegaard

    2008-01-01

    of Palaeocene (Danian) limestone. Stable isotopes (18O and 2H), strontium isotopes (87Sr/86Sr) and the elements Sr and Cl were measured to delineate the mixing of seawater and groundwater in the shallow aquifer and to determine the contribution from different water sources along the flow paths. The stable...... and lower part of the water body in the shallow sandy aquifer. The leakage of deep groundwater increased during the intrusion experiment as a result of the large abstraction of groundwater. Following the ceasing of the groundwater pumping, the interface went from being vertical to being predominantly...

  12. Radionuclide transport report for the safety assessment SR-Site

    Energy Technology Data Exchange (ETDEWEB)

    2010-12-15

    This document compiles radionuclide transport calculations of a KBS-3 repository for the safety assessment SR-Site. The SR-Site assessment supports the licence application for a final repository at Forsmark, Sweden

  13. The accumulation and elimination of 89Sr in tea leaves

    International Nuclear Information System (INIS)

    Zhang Yongxi; Wang Shouxiang; Chen Chuanqun; Sun Zhiming; Hu Bingmin; Huang Dan

    1995-01-01

    The 89 Sr was added to the tea tree-soil system by different ways. The 89 Sr in the system through the over-ground part of tea tree, was much more than that through soil. The 89 Sr concentration in older leaves was higher than in shoot for a definite treatment. The accumulation elimination law of 89 Sr in leaves varied with the treatments. For the treatment through the over-ground part, the 89 Sr concentration in older leaves and shoot was monotonously decreased with time increasing. But for the treatment through soil the 89 Sr concentration in shoot was increased to reach a peak value, and then decreased slowly; while the 89 Sr concentration in older leaves increased quickly in a period, then increased slowly to attain a saturated value. In addition, the concentration factor of 89 Sr in older leaves and shoot were determined

  14. The Leu33/Pro polymorphism (PlA1/PlA2) of the glycoprotein IIIa (GPIIIa) receptor is not related to myocardial infarction in the ECTIM Study. Etude Cas-Temoins de l'Infarctus du Myocarde.

    Science.gov (United States)

    Herrmann, S M; Poirier, O; Marques-Vidal, P; Evans, A; Arveiler, D; Luc, G; Emmerich, J; Cambien, F

    1997-06-01

    The GPIIb/IIIa receptor complex may contribute to acute coronary syndromes by mediating platelet aggregation. The Leu33/Pro polymorphism (PlA1/PlA2) of the GPIIIa has recently been shown to be associated with CHD in a small case-control study. We have investigated this polymorphism in a large multicenter study of patients with myocardial infarction and controls and found no difference in the distribution of allele and genotype frequencies between cases and controls.

  15. The helicase and RNaseIIIa domains of Arabidopsis Dicer-Like1 modulate catalytic parameters during MicroRNA biogenesis

    KAUST Repository

    Liu, Chenggang

    2012-04-03

    Dicer-Like1 (DCL1), an RNaseIII endonuclease, and Hyponastic Leaves1 (HYL1), a double-stranded RNA-binding protein, are core components of the plant microRNA (miRNA) biogenesis machinery. hyl1 mutants accumulate low levels of miRNAs and display pleiotropic developmental phenotypes. We report the identification of five new hyl1 suppressor mutants, all of which are alleles of DCL1. These new alleles affect either the helicase or the RNaseIIIa domains of DCL1, highlighting the critical functions of these domains. Biochemical analysis of the DCL1 suppressor variants reveals that they process the primary transcript (pri-miRNA) more efficiently than wild-type DCL1, with both higher Kcat and lower Km values. The DCL1 variants largely rescue wild-type miRNA accumulation levels in vivo, but do not rescue the MIRNA processing precision defects of the hyl1 mutant. In vitro, the helicase domain confers ATP dependence on DCL1-catalyzed MIRNA processing, attenuates DCL1 cleavage activity, and is required for precise MIRNA processing of some substrates. © 2012 American Society of Plant Biologists.

  16. Development of 87Sr/86Sr maps as targeted strategy to support wine quality.

    Science.gov (United States)

    Durante, Caterina; Bertacchini, Lucia; Cocchi, Marina; Manzini, Daniela; Marchetti, Andrea; Rossi, Maria Cecilia; Sighinolfi, Simona; Tassi, Lorenzo

    2018-07-30

    This study summarizes the results obtained from a systematic and long-term project aimed at the development of tools to assess the provenance of food in the oenological sector. In particular, 87 Sr/ 86 Sr isotope ratios were measured on statistically representative set of soils, vine branches and wines sampled in the production district of Modena, worldwide known for the Lambrusco wines production. The obtained data were used to build strontium isotopic maps able to objectively support the Lambrusco PDO wines origin as well as other products of the Modena district. Finally, a strong relationship was found between the 87 Sr/ 86 Sr isotope ratios of soils and vine branches on a large scale, highlighting and confirming once more the idea that plants can also represent an optimal sampling device to support geographical traceability. Copyright © 2018 Elsevier Ltd. All rights reserved.

  17. Shape coexistence in neutron-rich Sr isotopes : Coulomb excitation of 98Sr

    NARCIS (Netherlands)

    Clément, E; Görgen, A.; Korten, W.; Walle J. van de, [No Value

    2010-01-01

    In this addendum we ask for beam time to perform Coulomb excitation of 98Sr in order to complete our program on the study of shape coexistence and evolution of collectivity in neutron rich strontium isotopes at N=60.

  18. Comparison of mediastinal lymph node status and relapse pattern in clinical stage IIIA non‐small cell lung cancer patients treated with neoadjuvant chemotherapy versus upfront surgery: A single center experience

    Science.gov (United States)

    Savic, Milan; Ercegovac, Maja; Stojsic, Jelena; Bascarevic, Slavisa; Moskovljevic, Dejan; Kostic, Marko; Vesovic, Radomir; Popevic, Spasoje; Laban, Marija; Markovic, Jelena; Jovanovic, Dragana

    2017-01-01

    Background In spite of the progress made in neoadjuvant therapy for operable non small‐cell lung cancer (NSCLC), many issues remain unsolved, especially in locally advanced stage IIIA. Methods Retrospective data of 163 patients diagnosed with stage IIIA NSCLC after surgery was analyzed. The patients were divided into two groups: a preoperative chemotherapy group including 59 patients who received platinum‐etoposide doublet treatment before surgery, and an upfront surgery group including 104 patients for whom surgical resection was the first treatment step. Adjuvant chemotherapy or/and radiotherapy was administered to 139 patients (85.3%), while 24 patients (14.7%) were followed‐up only. Results The rate of N2 disease was significantly higher in the upfront surgery group (P  0.05). Conclusion There was significant difference in preoperative chemotherapy group regarding relapse rate and treatment outcomes related to the lymph node status comparing to the upfront surgery group. Neoadjuvant/adjuvant chemo‐therapy is a part of treatment for patients with stage IIIA NSCLC, but further investigation is required to determine optimal treatment. PMID:28671758

  19. Strontium adsorption and penetration in kaolinite at low Sr

    NARCIS (Netherlands)

    Ning, Zigong; Ishiguro, Munehide; Koopal, Luuk K.; Sato, Tsutomu; Kashiwagi, Junichi

    2017-01-01

    Behavior of radioactive strontium (Sr2+) in contaminated soils is an important issue in relation to nuclear power plant accidents. The Sr2+ adsorption on kaolinite and its migration in a kaolinite soil were investigated because toxic effects of radioactive Sr2+ have been found to be very severe for

  20. Electronic structure of Ca, Sr, and Ba under pressure.

    Science.gov (United States)

    Animalu, A. O. E.; Heine, V.; Vasvari, B.

    1967-01-01

    Electronic band structure calculations phase of Ca, Sr and Ba over wide range of atomic volumes under pressure electronic band structure calculations for fcc phase of Ca, Sr and Ba over wide range of atomic volumes under pressure electronic band structure calculations for fcc phase of Ca, Sr and Ba over wide range of atomic volumes under pressure

  1. Unconscious Priming According to Multiple S-R Rules

    Science.gov (United States)

    Kiesel, Andrea; Kunde, Wilfried; Hoffmann, Joachim

    2007-01-01

    The present study investigated if unconscious primes can be processed according to different stimulus-response (S-R) rules simultaneously. Participants performed two different S-R rules, such as judging a digit as smaller or larger than five and judging a letter as vowel or consonant. These S-R rules were administered in random order and announced…

  2. Determination of Cs-137, Sr-89 and Sr-90 and gamma spectroscopy of water samples from the Danube River

    International Nuclear Information System (INIS)

    Tschurlovits, M.

    1980-01-01

    Radioactivity concentration of Cs-137, Sr-90, Sr-89, Co-60 and K-40 from the Danube water in the period of 1977-1979. A few systematic changes in the radioactivity concentrations were observed and presented. (author)

  3. Revisiones de cadera en defectos óseos femorales Paprosky II y IIIA Utilización de prótesis no cementada, modular, de fijación proximal y anclaje distal. [Revision total hip arthroplasty in Paprosky II and IIIA femoral bone defects. Use of modular uncemented stems with proximal fixation ].

    Directory of Open Access Journals (Sweden)

    German Garabano

    2016-05-01

    Full Text Available Introducción: El objetivo de este estudio retrospectivo fue observar el comportamiento de un tallo modular de fijación proximal y anclaje distal en revisiones de cadera con defectos femorales II y IIIA (Praposky, evaluando la estabilidad protésica y articular, la restauración del off-set y la discrepancia de longitud. Materiales: Analizamos 22 RRTC de los cuales 12 (56,5% fueron mujeres y 10 varones con un promedio de edad de 62,38 años. El seguimiento promedio fue de 62 meses. El tallo femoral utilizado fue el S-ROM ® (Depuy – J&J. Los defectos óseos femorales fueron 15 tipo II y 7 IIIA de Praposky. Para la evaluación clínica se utilizó el Score de cadera de Harris (HHS. Radiológicamente se analizó el comportamiento del tallo, su integración, la discrepancia de longitud y el off-set femoral, considerándose como correcto una diferencia menor a 5mm. Resultados: el offset fue restaurado en 16 (72,3% casos y la longitud de miembros se restauró en 15 (68,2%. Hubo un solo hundimiento del tallo, y de acuerdo con Engh se observaron 17 (77,27% uniones óseas. Hubieron 7 (31,8% complicaciones, 2 luxaciones que requirieron revisión, 4 fracturas intra-operatorias y una paresia de CPE.   Conclusión este tallo impresiona ser una alternativa valida para resolver un problema complejo. Por su versatilidad, permite resolver mecánicamente el defecto óseo, devuelve la longitud al miembro y el off set a la articulación, presentando un índice de complicaciones aceptables.

  4. Synthesis, crystal structure, and TEM analysis of Sr19Li44 and Sr3Li2: a reinvestigation of the Sr-Li phase diagram.

    Science.gov (United States)

    Smetana, Volodymyr; Kienle, Lorenz; Duppel, Viola; Simon, Arndt

    2015-02-02

    Two intermetallic phases in the Sr-Li system have been synthesized and structurally characterized. According to single-crystal X-ray diffraction data, Sr(19)Li(44) and Sr(3)Li(2) crystallize with tetragonal unit cells (Sr(19)Li(44), I-42d, a = 15.9122(7) Å, c = 31.831(2) Å, Z = 4, V = 8059(2) Å(3); Sr(3)Li(2), P42/mnm, a = 9.803(1) Å, c = 8.784(2) Å, Z = 4, V = 844.2(2) Å(3)). The first compound is isostructural with the recently discovered Ba(19)Li(44). Sr in Sr(19)Li(44) can be fully replaced by Ba with no changes to the crystal structure, whereas the substitution of Sr by Ca is only possible within a limited concentration range. Sr(3)Li(2) can be assigned to the Al(2)Zr(3) structure type. The crystal structure determination of Sr(19)Li(44) was complicated by multiple twinning. As an experimental highlight, an electron microscopy investigation of the highly moisture- and electron-beam-sensitive crystals was performed, enabling high-resolution imaging of the defect structure.

  5. Tomato SR/CAMTA transcription factors SlSR1 and SlSR3L negatively regulate disease resistance response and SlSR1L positively modulates drought stress tolerance.

    Science.gov (United States)

    Li, Xiaohui; Huang, Lei; Zhang, Yafen; Ouyang, Zhigang; Hong, Yongbo; Zhang, Huijuan; Li, Dayong; Song, Fengming

    2014-10-28

    The SR/CAMTA proteins represent a small family of transcription activators that play important roles in plant responses to biotic and abiotic stresses. Seven SlSR/CAMTA genes were identified in tomato as tomato counterparts of SR/CAMTA; however, the involvement of SlSRs/CAMTAs in biotic and abiotic stress responses is not clear. In this study, we performed functional analysis of the SlSR/CAMTA family for their possible functions in defense response against pathogens and tolerance to drought stress. Expression of SlSRs was induced with distinct patterns by Botrytis cinerea and Pseudomonas syringae pv. tomato (Pst) DC3000. Virus-induced gene silencing (VIGS)-based knockdown of either SlSR1 or SlSR3L in tomato resulted in enhanced resistance to B. cinerea and Pst DC3000 and led to constitutive accumulation of H2O2, elevated expression of defense genes, marker genes for pathogen-associated molecular pattern-triggered immunity, and regulatory genes involved in the salicylic acid- and ethylene-mediated signaling pathways. Furthermore, the expression of SlSR1L and SlSR2L in detached leaves and whole plants was significantly induced by drought stress. Silencing of SlSR1L led to decreased drought stress tolerance, accelerated water loss in leaves, reduced root biomass and attenuated expression of drought stress responsive genes in tomato. The SlSR1 and SlSR3L proteins were localized in the nucleus of plant cells when transiently expressed in Nicotiana benthamiana and had transcriptional activation activity in yeast. VIGS-based functional analyses demonstrate that both SlSR1 and SlSR3L in the tomato SlSR/CAMTA family are negative regulators of defense response against B. cinerea and Pst DC3000 while SlSR1L is a positive regulator of drought stress tolerance in tomato.

  6. In situ Sr/Sr investigation of igneous apatites and carbonates using laser-ablation MC-ICP-MS

    DEFF Research Database (Denmark)

    Bizzarro, Martin; Simonetti, A.; Stevenson, R.K.

    2003-01-01

    homogeneity among coexisting igneous minerals containing high Sr (>3000 ppm) and low Rb ( « 1 ppm) contents within a single ~ 50-µm-thin-section mount. This technique is capable of producing measured Sr/Sr values with analytical precision (~ 0.005%, 2s) approaching those obtained by thermal ionization mass...

  7. Transport of Sr 2+ and SrEDTA 2- in partially-saturated and heterogeneous sediments

    Science.gov (United States)

    Pace, M. N.; Mayes, M. A.; Jardine, P. M.; McKay, L. D.; Yin, X. L.; Mehlhorn, T. L.; Liu, Q.; Gürleyük, H.

    2007-05-01

    Strontium-90 has migrated deep into the unsaturated subsurface beneath leaking storage tanks in the Waste Management Areas (WMA) at the U.S. Department of Energy's (DOE) Hanford Reservation. Faster than expected transport of contaminants in the vadose zone is typically attributed to either physical hydrologic processes such as development of preferential flow pathways, or to geochemical processes such as the formation of stable, anionic complexes with organic chelates, e.g., ethylenediaminetetraacetic acid (EDTA). The goal of this paper is to determine whether hydrological processes in the Hanford sediments can influence the geochemistry of the system and hence control transport of Sr 2+ and SrEDTA 2-. The study used batch isotherms, saturated packed column experiments, and an unsaturated transport experiment in an undisturbed core. Isotherms and repacked column experiments suggested that the SrEDTA 2- complex was unstable in the presence of Hanford sediments, resulting in dissociation and transport of Sr 2+ as a divalent cation. A decrease in sorption with increasing solid:solution ratio for Sr 2+ and SrEDTA 2- suggested mineral dissolution resulted in competition for sorption sites and the formation of stable aqueous complexes. This was confirmed by detection of MgEDTA 2-, MnEDTA 2-, PbEDTA 2-, and unidentified Sr and Ca complexes. Displacement of Sr 2+ through a partially-saturated undisturbed core resulted in less retardation and more irreversible sorption than was observed in the saturated repacked columns, and model results suggested a significant reservoir (49%) of immobile water was present during transport through the heterogeneous layered sediments. The undisturbed core was subsequently disassembled along distinct bedding planes and subjected to sequential extractions. Strontium was unequally distributed between carbonates (49%), ion exchange sites (37%), and the oxide (14%) fraction. An inverse relationship between mass wetness and Sr suggested that

  8. A method for determination of 90Sr in vegetation

    International Nuclear Information System (INIS)

    Nygren, U.

    1998-12-01

    This report describes a method for determination of 90 Sr in vegetation. The method consists of wet-ashing the samples and separating Sr from the sample matrix by oxalate precipitation and extraction chromatography. 90 Y ingrowth is awaited after which Y is separated from Sr and 90 Y measured in a proportional counter. The method has been applied on two reference materials and the 90 Sr results agree well with the recommended values. The method has also been used on 20 samples of blueberry twigs and the mean recovery of Sr was 74%

  9. Sr - an element shows the way - Applications of Sr isotopes for provenance, tracing and migration (Invited)

    Science.gov (United States)

    Prohaska, T.; Irrgeher, J.; Zitek, A.; Teschler Nicola, M.

    2010-12-01

    Strontium - named after the small Scottish town Strontian - as such is an element with little popularity. Firstly described by Martin Heinrich Klaproth in 1798, the metal is used in metallurgy to some extent whereas its compounds are interesting in glass industries, electronics and pyrotechnics. The element has chemical similarity to Ca and makes up 1/60 of the earth’s amount of the latter. Nonetheless, it is its isotopic composition which makes Sr so interesting for a large number of scientists. The natural composition of the four naturally occurring isotopes (84Sr, 86Sr 87Sr and 88Sr) varies in nature due to the radioactive decay of 87Rb to 87Sr. Thus, it was early recognized as geochronometer especially in Ca rich matrices. With increasing precision of applied methodology, the natural variation of the 87Sr/86Sr isotope ratio (analyzed at first mainly by thermal ionization mass spectrometry (TIMS)) became more and more popular in provenance studies. The natural variation of the ratio is mainly determined by the geological age and the original composition of the rock and can be used therefore as fingerprint of the local geology. The ratio is transferred with no significant fractionation via the water into plants and finally via the food chain into animal and human tissues (especially bones and teeth). As the element is chemically similar to Ca, it appears in most matrices. The use for provenance studies is supported by the fact that the long half life (4.8 x 1010 years) does not lead to an alteration during the time scales which are investigated (from recent samples to human or animal skeletal remains which date back up to 30.000 BC). The uniqueness of the system besides the natural variation is defined by the ubiquity in nature and the relatively high (and thus measurable) elemental concentration in most tissues. It was finally the advent of multiple collector inductively coupled plasma mass spectrometry (MC-ICP-MS) which augmented the number of applications

  10. Experimental autoabsorption curve 90Sr in SrCO3. Efficiency calculation to detection of 90Sr, 90Y and 90Sr + 90Y in a beta gas proportional counter

    International Nuclear Information System (INIS)

    Gasco, C.; Alvarez, A.

    1987-01-01

    Strontium-90 has been determined by radiochemical separation techniques in environmental samples. These techniques, of course, cannot separate the two strontium radionuclides from each other of from stable strontium. Consequently the end product of the chemical separation contains all strontium isotopes in SrCO 3 . The beta particules emitted by 90 Sr are absorbed by the SrCO 3 precipitate. This is the main source of error in the activity measurement. It has been prepared sources of 90 Sr in SrCO 3 in order to determinate the counting efficiency and autoabsorption curve. Also detection efficiencies have been calibrated using known activities of 90 Y and equilibrium mixture of 90 Sr+ 90 Y in the same geometry than our samples. The activity of 90 Sr by ingrowth of 90 Y has been calculated by our computer program. (author). 2 figs., 3 refs

  11. Strontium (Sr) separation from seawater using titanate adsorbents: Effects of seawater matrix ions on Sr sorption behavior

    Science.gov (United States)

    Ryu, Jungho; Hong, Hye-jin; Ryu, Taegong; Park, In-Su

    2017-04-01

    Strontium (Sr) which has many industrial applications such as ferrite magnet, ceramic, and fire works exists in seawater with the concentration of approximately 7 mg/L. In previous report estimating economic potential on recovery of various elements from seawater in terms of their commercial values and concentrations in seawater, Sr locates upper than approximate break-even line, which implies Sr recovery from seawater can be potentially profitable. Recently, Sr separation from seawater has received great attention in the environmental aspect after Fukushima Nuclear Power Plant (NPP) accident which released much amount of radioactive Sr and Cs. Accordingly, the efficient separation of radioactive elements released to seawater has become critical as an important technological need as well as their removal from radioactive wastes. So far, it has been introduced to separate Sr from aqueous media by various methods including solvent extraction, adsorption by solid materials, and ion exchange. Among them, the adsorption technique using solid adsorbents is of great interest for selectively separating Sr from seawater with respect to low concentration level of Sr. In this study, we synthesized titanate nanotube (TiNT) by simple hydrothermal reaction, characterized its physicochemical properties, and systematically evaluated Sr sorption behavior under various reaction conditions corresponding to seawater environment. The synthesized TiNT exhibited the fibril-type nanotube structure with high specific surface area of 260 m2/g. The adsorption of Sr on TiNT rapidly occurred following pseudo-second-order kinetic model, and was in good agreement with Langmuir isotherm model, indicating maximum adsorption capacity of 97 mg/g. Based on Sr uptake and Na release with stoichiometric balance, sorption mechanism of Sr on TiNT was found to be ion-exchange between Na in TiNT lattice and Sr in solution phase, which was also confirmed by XRD and Raman analysis. Among competitive ions, Ca

  12. Free enthalpy landscape of SrO.

    Science.gov (United States)

    Schön, J C; Cancarević, Z P; Hannemann, A; Jansen, M

    2008-05-21

    Trying to predict thermodynamically stable and metastable solid compounds as function of pressure and temperature requires the global exploration of the enthalpy landscapes of chemical systems and the subsequent construction of their free enthalpy landscapes. In this work, we present a general approach to the determination of a free energy landscape. As an example, we construct the free enthalpy landscape of SrO for two different pressures on the empirical potential level and also compute various thermodynamic and elastic properties of SrO in the NaCl-, CsCl-, NiAs-, NbS-, TiP-, beta-BeO, sphalerite-, and wurtzite-structure type on an ab initio level. We employ density functional theory within the hybrid B3LYP approximation. The results show good agreement with experimental and theoretical data.

  13. The μSR facilities at PSI

    International Nuclear Information System (INIS)

    Abela, R.; Baines, C.; Donath, X.; Herlach, D.; Maden, D.; Reid, I.D.; Renker, D.; Solt, G.; Zimmermann, U.

    1994-01-01

    The μSR Facility Instruments presently available at PSI and the envisaged medium- and long-term developments are presented. The plans focus on further upgrades of the existing instruments and the development of new techniques using the very high fluxes becoming available at PSI, in particular the setup of a beamline with a fast kicker for 'muons on request' (MORE) and the development of very low energy muon beams. (orig.)

  14. μSR data analysis with XYfit

    International Nuclear Information System (INIS)

    Tucakov, Ivan; Brewer, Jess H.; Froese, Aaron; Lau, Angus

    2006-01-01

    The CERN MINUIT library has recently been ported to C++, facilitating the incorporation of that familiar package into a general purpose fitting application called XYfit with a graphical user interface built with Qt3. Custom theory functions can easily be added as 'plugins' to XYfit, which reads in DataTables in XML format generated by the μView spreadsheet utility (which see), thus allowing more flexible fitting of μSR spectra

  15. Implicazioni cliniche ed economiche di tramadolo SR

    Directory of Open Access Journals (Sweden)

    Lorenzo Pradelli

    2004-12-01

    Full Text Available Tramadol is one of the preferred weak opioid agonists in the management of chronic pain, due to a good efficacy and safety profile, to a particularly low interference with cardiovascular and respiratory functions and a low dependence and abuse potential. The successful use of tramadol, nevertheless, is often limited by low patient compliance, a consequence of gastrointestinal side effects (mainly nausea and vomiting and frequent dosing regimens, among other reasons. In this paper, clinical studies conducted on slow-release formulations of tramadol and other strategies for compliance improvement in various pain conditions are reviewed. From the examined literature, it appears that the strategy with the best compliance is the use of slow release (SR formulations, which simplify dosing regimens and tend to have a somewhat better tolerability, and a slow dose escalation, which improves tolerability. The advantages of SR formulations have to be weighed against the superior acquisition cost and the slower onset of analgesia. A frame for the evaluation of the clinical and economical advantages and disadvantages of SR versus immediate release formulations of tramadol is also proposed.

  16. Characterization of two PEBP genes, SrFT and SrMFT, in thermogenic skunk cabbage (Symplocarpus renifolius).

    Science.gov (United States)

    Ito-Inaba, Yasuko; Masuko-Suzuki, Hiromi; Maekawa, Haruhiko; Watanabe, Masao; Inaba, Takehito

    2016-07-08

    Floral thermogenesis has been found in dozens of primitive seed plants and the reproductive organs in these plants produce heat during anthesis. Thus, characterization of the molecular mechanisms underlying flowering is required to fully understand the role of thermogenesis, but this aspect of thermogenic plant development is largely unknown. In this study, extensive database searches and cloning experiments suggest that thermogenic skunk cabbage (Symplocarpus renifolius), which is a member of the family Araceae, possesses two genes encoding phosphatidyl ethanolamine-binding proteins (PEBP), FLOWERING LOCUS T (SrFT) and MOTHER OF FT AND TFL1 (SrMFT). Functional analyses of SrFT and SrMFT in Arabidopsis indicate that SrFT promotes flowering, whereas SrMFT does not. In S. renifolius, the stage- and tissue-specific expression of SrFT was more evident than that of SrMFT. SrFT was highly expressed in flowers and leaves and was mainly localized in fibrovascular tissues. In addition, microarray analysis revealed that, within floral tissues, SrFT was co-regulated with the genes associated with cellular respiration and mitochondrial function, including ALTERNATIVE OXIDASE gene proposed to play a major role in floral thermogenesis. Taken together, these data suggest that, among the PEBP genes, SrFT plays a role in flowering and floral development in the thermogenic skunk cabbage.

  17. Cement augmentation in the proximal femur to prevent stem subsidence in revision hip arthroplasty with Paprosky type II/IIIa defects.

    Science.gov (United States)

    Tsai, Shang-Wen; Chen, Cheng-Fong; Wu, Po-Kuei; Chen, Chao-Ming; Chen, Wei-Ming

    2018-02-07

    Subsidence remains a common complication after revision hip arthroplasty which may lead to prolonged weight-bearing restrictions, leg-length discrepancies or considerable loss of function. We evaluated the effectiveness of cement augmentation in the proximal femoral metaphysis during a revision of femoral components to prevent post-operative stem subsidence. Forty patients were enrolled. Follow-up averaged 67.7 months (range: 24-149). Twenty-seven patients had a Paprosky type II defect and 13 had a type IIIa defect. All revision hip arthroplasty used a cementless, cylindrical, non-modular cobalt-chromium stem. The defect in the metaphysis was filled with antibiotic-loaded bone cement. Thirteen patients who had undergone stem revision only was allowed to walk immediately without weight-bearing restrictions. Twenty-seven patients who had undergone revision total hip arthroplasty was allowed partial weight-bearing within 6 weeks after surgery in the consideration of acetabular reconstruction. Three patients (7.5%) had post-surgery stem subsidences of three mm, five mm, and 10 mm, respectively, at three, one, and 14 months. There were no acute surgical site infections. There were three femoral stem failures: two delayed infections and one periprosthetic Vancouver B2 fracture. Both five- and 10-year survivorships of the femoral implant were 90.1%. An adequate length of the scratch-fit segment and diaphyseal ingrowth remain of paramount importance when revising femoral components. To fill metaphyseal bone defects with antibiotic-loaded bone cement may be an alternative method in dealing with proximal femoral bone loss during a femoral revision. Copyright © 2018. Published by Elsevier Taiwan LLC.

  18. Local Intracoronary Infusion of Glycoprotein IIb/IIIa Inhibitors via a Perfusion Catheter versus Intracoronary Guiding Catheter Injection during Primary Percutaneous Coronary Intervention: A Pilot Observational Study.

    Science.gov (United States)

    Zaki, Tarek; Labib, Salwa; El-Abbady, Maged; El-Kilany, Wael; Mortada, Ayman; Rashid, Tarek; Ragy, Hany; El-Itreby, Adel; Nammas, Wail

    2017-05-01

    Glycoprotein IIb IIIa inhibitors improved short- and long-term outcome when added to primary percutaneous coronary intervention (PPCI) in patients with ST-segment-elevation myocardial infarction (STEMI). We hypothesized that intracoronary eptifibatide infusion via a perfusion catheter improves angiographic and clinical outcome of patients with STEMI undergoing PPCI, versus conventional intracoronary bolus injection. Prospectively, we enrolled 80 patients with acute STEMI and thrombolysis in myocardial infarction (TIMI) thrombus grade ≥ 2. Patients were assigned to receive eptifibatide (180 μg) either via a dedicated coronary perfusion catheter (ClearWay TM ) during PPCI (group I), or guiding catheter (group II). Assessment of TIMI thrombus grade, TIMI flow grade, and TIMI myocardial perfusion (TMP) grade was performed both at baseline and post- procedurally. The primary 'angiographic' endpoint was final TMP grade 0/1. The primary 'clinical' endpoint was a composite of cardiac death, non-fatal re-infarction, target vessel revascularization, and recurrent ischemia at 30-day follow-up. Mean age was 52.3 ± 8.9 years (17.5% females). Clearance of visible thrombus (TIMI thrombus grade 0) at final angiogram was more frequent in group I. Additionally, both final TIMI flow grade 3 and final TMP grade 3 occurred more frequently in group I. The primary angiographic endpoint was more frequent in group II versus group I (17.5% versus 0%, respectively, p = 0.001). The primary clinical endpoint was more frequent in group II (20% versus 0%, respectively, p = 0.003). In patients with STEMI, intracoronary eptifibatide infusion via a perfusion catheter during PPCI improved immediate angiographic outcome, and reduced clinical events at 30-day follow-up, versus bolus injection via the guiding catheter.

  19. Preparation of Sr adsorptive fiber by impregnating with crown ether derivative for 90Sr measurement

    International Nuclear Information System (INIS)

    Horita, Takuma; Asai, Shiho; Hanzawa, Yukiko; Kitatsuji, Yoshihiro; Konda, Miki; Saito, Kyoichi; Fujiwara, Kunio; Sugo, Takanobu

    2017-01-01

    A Sr adsorption fiber was prepared for rapid analysis of 90 Sr content in the fiber using radiation-induced emulsion graft polymerization and subsequent chemical modification. A polyethylene fiber with a diameter of 13 μm was first immersed in a methanol solution of an epoxy-group-containing vinyl monomer, glycidyl methacrylate (GMA), and polyoxyethylene sorbitol ester (Tween20) as a surfactant for the graft-polymerization of GMA. Octadecylamine was then bound to a polymer chain extending from the fiber surface, providing hydrophobicity to the polymer chain. Dicyclohexano-18-crown-6 (DCH18C6) was finally impregnated onto the polymer chain via a hydrophobic interaction between the octadecyl moiety of the polymer chain and the cyclohexyl moiety of DCH18C6. The fiber surface structure, characterized by DCH18C6 molecules loosely entangled with polymer chains, allowed for the rapid adsorption of Sr ions at an adsorption rate of approximately 100-times higher than that of a commercially available Sr-selective resin (Sr Resin ® ). (author)

  20. Internal Rb-Sr Age and Initial Sr-87/Sr-86 of a Silicate Inclusion from the Campo Del Cielo Iron Meteorite

    Science.gov (United States)

    Liu, Y.; Nyquist, L.; Wiesmann, H.; Shih, C.; Schwandt, C.; Takeda, H.

    2003-01-01

    The largest group of iron meteorites, IAB, is distinguished by the presence of diverse silicate inclusions. In principle, Rb-Sr and Sm-Nd radiometric dating of these silicate inclusions by internal isochron techniques can determine both the times of melting and parent/daughter ratios in the precursor materials via initial Sr-87/Sr-86 and Nd-143/Nd-144 ratios. The Sr-87/Sr-86 and Nd-143/Nd-144 ratios could distinguish chondritic precursors from already differentiated silicates. We reported Rb-Sr and Sm-Nd internal ischron ages of 4.52+/-0.03 Ga and 4.50+/-0.04 Ga, respectively, for plagioclase-diopside-rich material in the Caddo County IAB iron meteorite. These results are essentially identical to literature values of its Ar-Ar age of 4.520+/-0.005 Ga and its Sm-Nd age of 4.53+/-0.02 Ga. The purpose of this study is to evaluate the formation and evolution of silicate inclusions in IAB iron meteorites by determination of their initial Sr-87/Sr-86 ratios combined with higher-resolution chronology and mineralogical and geochemical studies.

  1. Some analytical aspects about determination of Sr89 and Sr90 in environmental samples

    International Nuclear Information System (INIS)

    Gasco, C.; Alvarez Garcia, A.

    1988-01-01

    Some problems about determination of Sr 89 and Sr 90 in environmental samples have been studied. The main difficulties are due to the wide range in the concentration of their components and the contents of chemical and radiochemical interferent elements. The behaviour of strontium on ion exchange resin has been described by some experiments in various media: aqueous media, calcium concentration and matrix variable. The differences of alkaline-earth nitrate and carbonate solubilities have been analyzed in nitric acid. The chemical recovery in environmental samples has been determined. (Author)

  2. The Presence of aac (6 ' Ie / aph (2 ", aph (3' - IIIa1, ant (4 ' - Ia1 Genes and Determining Methicillin Resistance in Staphylococcus Epidermidis and Staphylococcus Saprophyticus Strains Isolated from Clinical Specimens

    Directory of Open Access Journals (Sweden)

    Mohammad Bokaeian

    2017-02-01

    Full Text Available Abstract Background: Aminoglycosides are used as antibiotics in combination with beta-lactamas for many treatments of staphylococcal infections. Development of resistance in resistant strains can be done by enzymes produced by effective genes that cause the destruction of aminoglycoside antibiotics. The aim of this study was to investigate the prevalence of the aac (6 ' Ie / aph (2 ", aph (3' - IIIa1, ant (4 ' - Ia1 genes and mecA in staphylococcus strains which play an effective part in the resistance of aminoglycosides. Materials and Methods: in this descriptive cross-sectional observation, 113 clinical samples including 68 isolate of Staphylococcus epidermidis and 45 isolate of Staphylococcus saprophyticus of 459 clinical samples were identified by biochemical and molecular tests. The antibiotic susceptibility pattern of isolates was determined using MIC method by E-test strips. Then, to determine the presence of genes responsible for resistance to aminoglycosides, gene-specific primers were used. Results: Of 68 isolates obtained from saprophyticus Staphylococcus aureus, 39isolates(57.35% were mecA gene. As well, 13 isolates (19.11% have aac (6 ' Ie / aph (2 " gene, 9 isolates (13.23% have aph (3' - IIIa1 gene and 7 isolates (7.3% have ant (4 ' - Ia1 gene. Of 45 isolates of Staphylococcus saprophyticus, 23 isolates(51.11% have mecA genes, 8 isolates (17.77% have aac (6' Ie / aph (2 " gene, 4 isolates (8/8% have aph (3 ' - IIIa1 gene and 2 isolates (4.4% have gene ant (4' - Ia1 gen. Conclusion: Statistical analysis showed that the prevalence of aminoglycoside genes is more among strains resistant to methicillin and this would suggest that methicillin-resistant strains are easy situation for the acquisition of resistance to other antibiotics.

  3. Aliens or the SR-71 Blackbird?

    Science.gov (United States)

    Ruiz, Michael J.

    2006-04-01

    Unidentified flying objects (UFOs) capture the interest of our students and the general public.1,2 Here is a UFO story I tell my students to illustrate the workings of science. Science, at its most fundamental level, is observation and an attempt to analyze what is observed. But what happens when an observation cannot be explained with the available knowledge at the time? What do we do? The UFO sighting of my story could not be explained until disclosure of a top-secret military aircraft, the SR-71, also known as the "Blackbird."

  4. Carrier-Controlled Ferromagnetism in SrTiO_{3}

    Directory of Open Access Journals (Sweden)

    Pouya Moetakef

    2012-06-01

    Full Text Available Magnetotransport and superconducting properties are investigated for uniformly La-doped SrTiO_{3} films and GdTiO_{3}/SrTiO_{3} heterostructures, respectively. GdTiO_{3}/SrTiO_{3} interfaces exhibit a high-density 2D electron gas on the SrTiO_{3} side of the interface, while, for the SrTiO_{3} films, carriers are provided by the dopant atoms. Both types of samples exhibit ferromagnetism at low temperatures, as evidenced by a hysteresis in the magnetoresistance. For the uniformly doped SrTiO_{3} films, the Curie temperature is found to increase with doping and to coexist with superconductivity for carrier concentrations on the high-density side of the superconducting dome. The Curie temperature of the GdTiO_{3}/SrTiO_{3} heterostructures scales with the thickness of the SrTiO_{3} quantum well. The results are used to construct a stability diagram for the ferromagnetic and superconducting phases of SrTiO_{3}.

  5. [Exogenous Sr2+ sedimentation on otolith of chum salmon embryos].

    Science.gov (United States)

    Wang, Chen; Liu, Wei; Zhan, Pei-rong; Wang, Ji-long; Li, Pei-lun

    2015-10-01

    To explore the exogenous Sr2+ sedimentation on otolith of chum salmon embryos, chum salmon embryos were exposed to culture water contained Sr2+ at Sr2+ concentration of 50, 100, 200 or 400 mg . L-1 for 48 h to imitate Sr2+ sedimentation. After a culturing period of 12 d and 100 d, the otoliths of the chum salmon were taken to detect exogenous Sr2+ sedimentation with electro-probe microanalyzer (EPMA). The results showed that obvious deep red strontium signatures were produced in the otolith of chum salmon at different concentrations of Sr2+. The mean and extreme values of peak strontium area were not stable for the same Sr2+ dose, but the lowest of all the peak values was 35.1 times as much as that of control. Overall, the strontium value increased with the increase of Sr2+concentration. The strontium peak had no signs of abating after a culture period of 100 d. The results also showed that strontium was gradually deposited in the otolith, and had obvious hysteresis to immersion. Strontium sedimentation could also return to a normal level after the peak. These characteristics accorded exactly with the requirement of discharge tag technology, which indicated that exogenous Sr2+ was suitable in the marking of salmon otolith.

  6. Short-Course Hypofractionated Radiation Therapy With Boost in Women With Stages 0 to IIIa Breast Cancer: A Phase 2 Trial

    Energy Technology Data Exchange (ETDEWEB)

    Ahlawat, Stuti; Haffty, Bruce G.; Goyal, Sharad; Kearney, Thomas; Kirstein, Laurie [Rutgers Cancer Institute of New Jersey, New Jersey (United States); Chen, Chunxia; Moore, Dirk F. [Rutgers School of Public Health, Piscataway, New Jersey (United States); Khan, Atif J., E-mail: khanat@cinj.rutgers.edu [Rutgers Cancer Institute of New Jersey, New Jersey (United States)

    2016-01-01

    Purpose: Conventionally fractionated whole-breast irradiation (WBI) with a boost takes approximately 6 to 7 weeks. We evaluated a short course of hypofractionated (HF), accelerated WBI in which therapy was completed in 3 weeks inclusive of a sequential boost. Methods and Materials: We delivered a whole-breast dose of 36.63 Gy in 11 fractions of 3.33 Gy over 11 days, followed by a lumpectomy bed boost in 4 fractions of 3.33 Gy delivered once daily for a total of 15 treatment days. Acute toxicities were scored using Common Terminology Criteria for Adverse Events version 4. Late toxicities were scored using the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer scale. Cosmesis was scored using the Harvard Cosmesis Scale. Our primary endpoint was freedom from locoregional failure; we incorporated early stopping criteria based on predefined toxicity thresholds. Cosmesis was examined as a secondary endpoint. Results: We enrolled 83 women with stages 0 to IIIa breast cancer. After a median follow-up of 40 months, 2 cases of isolated ipsilateral breast tumor recurrence occurred (2 of 83; crude rate, 2.4%). Three-year estimated local recurrence-free survival was 95.9% (95% confidence interval [CI]: 87.8%-98.7%). The 3-year estimated distant recurrence-free survival was 97.3% (95% CI: 89.8%-99.3%). Three-year secondary malignancy-free survival was 94.3% (95% CI: 85.3%-97.8%). Twenty-nine patients (34%) had grade 2 acute toxicity, and 1 patient had a late grade 2 toxicity (fibrosis). One patient had acute grade 3 dermatitis, whereas 2 patients experienced grade 3 late skin toxicity. Ninety-four percent of evaluable patients had good or excellent cosmesis. Conclusions: Our phase 2 institutional study offers one of the shortest courses of HF therapy, delivered in 15 fractions inclusive of a sequential boost. We demonstrated expected low toxicity and high local control rates with good to excellent cosmetic outcomes. This

  7. Restricted processing of CD16a/Fc γ receptor IIIa N-glycans from primary human NK cells impacts structure and function.

    Science.gov (United States)

    Patel, Kashyap R; Roberts, Jacob T; Subedi, Ganesh P; Barb, Adam W

    2018-03-09

    CD16a/Fc γ receptor IIIa is the most abundant antibody Fc receptor expressed on human natural killer (NK) cells and activates a protective cytotoxic response following engagement with antibody clustered on the surface of a pathogen or diseased tissue. Therapeutic monoclonal antibodies (mAbs) with greater Fc-mediated affinity for CD16a show superior therapeutic outcome; however, one significant factor that promotes antibody-CD16a interactions, the asparagine-linked carbohydrates ( N -glycans), remains undefined. Here, we purified CD16a from the primary NK cells of three donors and identified a large proportion of hybrid (22%) and oligomannose N -glycans (23%). These proportions indicated restricted N -glycan processing and were unlike those of the recombinant CD16a forms, which have predominantly complex-type N -glycans (82%). Tethering recombinant CD16a to the membrane by including the transmembrane and intracellular domains and via coexpression with the Fc ϵ receptor γ-chain in HEK293F cells was expected to produce N -glycoforms similar to NK cell-derived CD16a but yielded N -glycoforms different from NK cell-derived CD16a and recombinant soluble CD16a. Of note, these differences in CD16a N -glycan composition affected antibody binding: CD16a with oligomannose N -glycans bound IgG1 Fc with 12-fold greater affinity than did CD16a having primarily complex-type and highly branched N -glycans. The changes in binding activity mirrored changes in NMR spectra of the two CD16a glycoforms, indicating that CD16a glycan composition also affects the glycoprotein's structure. These results indicated that CD16a from primary human NK cells is compositionally, and likely also functionally, distinct from commonly used recombinant forms. Furthermore, our study provides critical evidence that cell lineage determines CD16a N -glycan composition and antibody-binding affinity. © 2018 by The American Society for Biochemistry and Molecular Biology, Inc.

  8. A phase I/IIa study on intra-articular injection of holmium-166-chitosan complex for the treatment of knee synovitis of rheumatoid arthritis

    Energy Technology Data Exchange (ETDEWEB)

    Song, J.; Suh, C.H.; Park, Y.B.; Lee, S.H.; Lee, S.K. [Dept. of Internal Medicine, Yonsei University College of Medicine, Seoul (Korea); Yoo, N.C. [Dept. of Internal Medicine, Yonsei University College of Medicine, Seoul (Korea); Dept. of Clinical Pharmacology, Yonsei University College of Medicine, Seoul (Korea); Lee, J.D. [Dept. of Nuclear Medicine, Yonsei University College of Medicine, Seoul (Korea); Kim, K.H. [Dept. of Clinical Pharmacology, Yonsei University College of Medicine, Seoul (Korea)

    2001-04-01

    Previous animal studies have established that the intra-articular injection of holmium-166-chitosan complex (DW-166HC) causes effective necrosis of the inflamed synovium with little leakage of radioactivity from the injected joint. Based on these findings, we conducted a phase I/IIa study to examine the biodistribution of DW-166HC and to assess the safety of DW-166HC for the treatment of knee synovitis in patients with rheumatoid arthritis (RA). A total of 16 patients [1 man, 15 women; median age 49 (range 36-65) years] who had RA knee synovitis refractory to disease-modifying antirheumatic drug treatments of >3 months' duration were randomly assigned to three treatment groups with different radiation doses of DW-166HC: 370 MBq (n=6), 555 MBq (n=5) and 740 MBq (n=5). In each treatment group, blood and urine radioactivity were analysed by beta counter and biodistribution of the injected DW-166HC was evaluated using a gamma scan camera. Clinical assessment was done according to three variables (evaluation method): knee joint pain (visual analogue scale), range of motion (goniometry) and joint swelling (circumference of knee joint). The duration of follow-up observation was 3 months. Following the intra-articular injection of DW-166HC, the blood radioactivity was little changed from the baseline measurement and the accumulated radioactivity excreted in urine was minimal. Gamma scan study indicated that most of the injected radiochemical was localized within the injected joint cavity, and the extra-articular leakage was negligible at 24 h after the injection: brain, 0.3%; lung, 0.6%; abdomen, 0.7%; and pelvis, 0.8%. Major adverse events were transient post-injection knee joint pain and swelling. These results suggest that DW-166HC might be a safe agent for radiation synovectomy, particularly for the treatment of knee synovitis of RA, and further trials in a larger patient population are warranted to evaluate the therapeutic efficacy of DW-166HC. (orig.)

  9. Deficiencies in both starch synthase IIIa and branching enzyme IIb lead to a significant increase in amylose in SSIIa-inactive japonica rice seeds.

    Science.gov (United States)

    Asai, Hiroki; Abe, Natsuko; Matsushima, Ryo; Crofts, Naoko; Oitome, Naoko F; Nakamura, Yasunori; Fujita, Naoko

    2014-10-01

    Starch synthase (SS) IIIa has the second highest activity of the total soluble SS activity in developing rice endosperm. Branching enzyme (BE) IIb is the major BE isozyme, and is strongly expressed in developing rice endosperm. A mutant (ss3a/be2b) was generated from wild-type japonica rice which lacks SSIIa activity. The seed weight of ss3a/be2b was 74-94% of that of the wild type, whereas the be2b seed weight was 59-73% of that of the wild type. There were significantly fewer amylopectin short chains [degree of polymerization (DP) ≤13] in ss3a/be2b compared with the wild type. In contrast, the amount of long chains (DP ≥25) connecting clusters of amylopectin in ss3a/be2b was higher than in the wild type and lower than in be2b. The apparent amylose content of ss3a/be2b was 45%, which was >1.5 times greater than that of either ss3a or be2b. Both SSIIIa and BEIIb deficiencies led to higher activity of ADP-glucose pyrophosphorylase (AGPase) and granule-bound starch synthase I (GBSSI), which partly explains the high amylose content in the ss3a/be2b endosperm. The percentage apparent amylose content of ss3a and ss3a/be2b at 10 days after flowering (DAF) was higher than that of the wild type and be2b. At 20 DAF, amylopectin biosynthesis in be2b and ss3a/be2b was not observed, whereas amylose biosynthesis in these lines was accelerated at 30 DAF. These data suggest that the high amylose content in the ss3a/be2b mutant results from higher amylose biosynthesis at two stages, up to 20 DAF and from 30 DAF to maturity. © The Author 2014. Published by Oxford University Press on behalf of the Society for Experimental Biology.

  10. Prigranitshje. Forum v Jõhvi / Vitali Shkola

    Index Scriptorium Estoniae

    Shkola, Vitali

    2007-01-01

    Ülevaade Jõhvis toimunud rahvusvahelisest foorumist " Piiriäärsete regioonide koostöö. Informatsiooni ja reklaami tähtsus ettevõtluse ja turismi arengus", kus ettekandega esinesid ka Eesti regionaalminister Vallo Reimaa, parlamendiliige Valeri Korb ja Soome suursaadik Eestis Jaakko Kalela. Foorumit finantseeriti INTERREG IIIA programmi raames

  11. Production of {sup 89}Sr in solution reactor

    Energy Technology Data Exchange (ETDEWEB)

    Chuvilin, D.Yu. [Russian Research Centre ' Kurchatov Institute' , Kurchatov Sq., 1, Moscow (Russian Federation)], E-mail: dchuvilin@imp.kiae.ru; Khvostionov, V.E.; Markovskij, D.V.; Pavshook, V.A.; Ponomarev-Stepnoy, N.N.; Udovenko, A.N.; Shatrov, A.V.; Vereschagin, Yu. I. [Russian Research Centre ' Kurchatov Institute' , Kurchatov Sq., 1, Moscow (Russian Federation); Rice, J.; Tome, L.A. [TCI Medical, One Park Square, Suite 210, 6501 Americas Parkway, Albuquerque (United States)

    2007-10-15

    The new method for medical {sup 89}Sr production in a reactor with solution fuel is proposed which is characterized by simplicity, high production efficiency and low buildup of radioactive waste. The main advantages of the new technology were validated by numerous experiments. The proposed new technology selectively extracts {sup 89}Sr from a fuel of solution reactor and precludes penetration of {sup 90}Sr into the final product. This method is based on the presence of gaseous radionuclide {sup 89}Kr (T{sub 1/2}=190.7 s) in the decay chain {sup 89}Se{yields}{sup 89}Br{yields}{sup 89}Kr{yields}{sup 89}Rb{yields}{sup 89}Sr. The performed experiments on taking the gas probes from internal volume of the solution 20 kW mini-reactor 'Argus' have confirmed that the mechanism for {sup 89}Sr delivery to the sorption volume of the reactor experimental loop is based on transport of gaseous {sup 89}Sr predecessor-radionuclide {sup 89}Kr. According to the measurements of radioactive impurities in a final {sup 89}SrCl{sub 2} solution, the filtration of the gas flow with cermet filters followed by cleaning of {sup 89}Sr chloride solution in chromatographic columns with DOWEX-50x8 or Sr-Resin ensures reception of {sup 89}Sr fully meeting the requirements for medical application. The experimental estimations have shown that the proposed new technology is multiply more productive than the traditional industrial methods of {sup 89}Sr reception.

  12. Long-term treatment with the oncolytic ECHO-7 virus Rigvir of a melanoma stage IV M1c patient, a small cell lung cancer stage IIIA patient, and a histiocytic sarcoma stage IV patient-three case reports.

    Science.gov (United States)

    Alberts, Pēteris; Olmane, Evija; Brokāne, Linda; Krastiņa, Zanda; Romanovska, Māra; Kupčs, Kārlis; Isajevs, Sergejs; Proboka, Guna; Erdmanis, Romualds; Nazarovs, Jurijs; Venskus, Dite

    2016-10-01

    Oncolytic virotherapy is a recent addition to cancer treatment. Here, we describe positive treatment outcomes in three patients using Rigvir virotherapy. One of the patients is diagnosed with melanoma stage IV M1c, one with small cell lung cancer stage IIIA, and one with histiocytic sarcoma stage IV. The diagnoses of all patients are verified by histology or cytology. All patients started Rigvir treatment within a few months after being diagnosed and are currently continuing Rigvir treatment. The degree of regression of the disease has been determined by computed tomography. Safety assessment of adverse events graded according to NCI CTCAE did not show any value above grade 1 during Rigvir(®) treatment. Using current standard treatments, the survival of patients with the present diagnoses is low. In contrast, the patients described here were diagnosed 3.5, 7.0, and 6.6 years ago, and their condition has improved and been stabile for over 1.5, 6.5, and 4 years, respectively. These observations suggest that virotherapy using Rigvir can successfully be used in long-term treatment of patients with melanoma stage IV M1c, small cell lung cancer stage IIIA, and histiocytic sarcoma stage IV and therefore could be included in prospective clinical studies. © 2016 International Virotherapy Center. APMIS published by John Wiley & Sons Ltd.

  13. Preparation structure and dielectric behaviour of the system Sr La ...

    Indian Academy of Sciences (India)

    Formation of solid solution has been explored in the valence compensated perovskite oxide system Sr1-LaTi1-FeO3 ( ≤ 0.50). XRD studies indicate the formation of solid solution for the whole range investigated. All the compositions synthesised have cubic structure similar to undoped SrTiO3. Study of dielectric ...

  14. Geosphere process report for the safety assessment SR-Site

    Energy Technology Data Exchange (ETDEWEB)

    Skagius, Kristina (ed.) (Kemakta Konsult AB, Stockholm (Sweden))

    2010-11-15

    This report documents geosphere processes identified as relevant to the long-term safety of a KBS-3 repository, and forms an important part of the reporting of the safety assessment SR-Site. The detailed assessment methodology, including the role of the process reports in the assessment, is described in the SR-Site Main report /SKB 2011/

  15. Geosphere process report for the safety assessment SR-Site

    International Nuclear Information System (INIS)

    Skagius, Kristina

    2010-11-01

    This report documents geosphere processes identified as relevant to the long-term safety of a KBS-3 repository, and forms an important part of the reporting of the safety assessment SR-Site. The detailed assessment methodology, including the role of the process reports in the assessment, is described in the SR-Site Main report /SKB 2011/

  16. Determination of 90Sr from aqueous solutions using SPE extraction

    International Nuclear Information System (INIS)

    Dulanska, S.; Rajec, P.; Matel, L.

    2008-01-01

    Solid Phase Extraction (SPE) is widely used technique for the isolation and concentration of analytes from liquid samples to achieve increased sensitivity in the analytical process. Three commercial sorbents produced by three different manufacturers were tested. 3M Empore TM Strontium Rad Disks, Sr resin and AnaLig Sr-01 were used to efficiently isolate strontium from aqueous samples. (authors)

  17. Automaticity and Flexibility of S-R Retrieval During Priming.

    Science.gov (United States)

    Tobin, Hope; Race, Elizabeth

    2017-06-13

    Learned associations between stimuli and responses (S-R associations) make important contributions to behavioral and neural priming. The current study investigated the automaticity and flexibility of these S-R associations and whether the global task context in which they occur modulates the impact of S-R retrieval on priming. Participants engaged in a semantic repetition priming task in which S-R retrieval is known to influence priming. Across participants, repetition priming occurred in global task contexts (i.e., combination of activated task sets) that either remained consistent or shifted across time. In the stable context group, the global task context at study matched that at test, whereas in the shifting context group, the global task context at study differed from that at test. Results revealed that the stability of the global task context did not affect the magnitude of S-R contributions to priming and that S-R contributions to priming were significant in both the stable and shifting context groups. These results highlight the robustness of S-R contributions to priming and indicate that S-R associations can flexibly transfer across changes in higher-level task states.

  18. Thermodynamic modeling of the Sr-Co-Fe-O system

    DEFF Research Database (Denmark)

    Zhang, Wei Wei; Povoden-Karadeniz, Erwin; Chen, Ming

    2016-01-01

    This paper reviews and assesses phase equilibria and thermodynamic properties of phases in the Sr-Co-Fe-O system, with a focus on oxides, especially the SrCo1 - xFexO3 - δ perovskite. In our work, the SrCo1 - xFexO3 - δ perovskite was modeled with a three-sublattice model, where the three...... sublattices correspond to the A, B and oxygen sites in an ABO3 perovskite, respectively. A number of other important ternary oxide phases in Sr-Co-O and Sr-Co-Fe-O were also considered. Available thermodynamic and phase diagram data were carefully assessed. A thermodynamic description of Sr-Co-O was derived...... using the CALPHAD approach and was further extrapolated to that of Sr-Co-Fe-O. The thermodynamic database of Sr-Co-Fe-O established in this work allows for calculating phase diagrams, thermodynamic properties, cation distribution and defect chemistry properties, and therefore enables material...

  19. The study of accumulation of Sr 90 by plant cells

    International Nuclear Information System (INIS)

    Matusov, G.D.; Kudryashova, N.N.

    2002-01-01

    In this work the absorption and desorption of ions Sr 90 by plant cells and influence of different physical and chemical factors of environment on that processes were investigated. The kinetics of strontium accumulation have been obtained and the factors of accumulation of Sr 90 have been determined for a plant cell itself and its separate compartments

  20. Gefitinib versus vinorelbine plus cisplatin as adjuvant treatment for stage II-IIIA (N1-N2) EGFR-mutant NSCLC (ADJUVANT/CTONG1104): a randomised, open-label, phase 3 study.

    Science.gov (United States)

    Zhong, Wen-Zhao; Wang, Qun; Mao, Wei-Min; Xu, Song-Tao; Wu, Lin; Shen, Yi; Liu, Yong-Yu; Chen, Chun; Cheng, Ying; Xu, Lin; Wang, Jun; Fei, Ke; Li, Xiao-Fei; Li, Jian; Huang, Cheng; Liu, Zhi-Dong; Xu, Shun; Chen, Ke-Neng; Xu, Shi-Dong; Liu, Lun-Xu; Yu, Ping; Wang, Bu-Hai; Ma, Hai-Tao; Yan, Hong-Hong; Yang, Xue-Ning; Zhou, Qing; Wu, Yi-Long

    2018-01-01

    Cisplatin-based adjuvant chemotherapy is the standard of care for patients with resected stage II-IIIA non-small-cell lung cancer (NSCLC). RADIANT and SELECT trial data suggest patients with EGFR-mutant stage IB-IIIA resected NSCLC could benefit from adjuvant EGFR tyrosine kinase inhibitor treatment. We aimed to compare the efficacy of adjuvant gefitinib versus vinorelbine plus cisplatin in patients with completely resected EGFR-mutant stage II-IIIA (N1-N2) NSCLC. We did a randomised, open-label, phase 3 trial at 27 centres in China. We enrolled patients aged 18-75 years with completely resected (R0), stage II-IIIA (N1-N2), EGFR-mutant (exon 19 deletion or exon 21 Leu858Arg) NSCLC. Patients were stratified by N stage and EGFR mutation status and randomised (1:1) by Pocock and Simon minimisation with a random element to either gefitinib (250 mg once daily) for 24 months or intravenous vinorelbine (25 mg/m 2 on days 1 and 8) plus intravenous cisplatin (75 mg/m 2 on day 1) every 3 weeks for four cycles. The primary endpoint was disease-free survival in the intention-to-treat population, which comprised all randomised patients; the safety population included all randomised patients who received at least one dose of study medication. Enrolment to the study is closed but survival follow-up is ongoing. The study is registered with ClinicalTrials.gov, number NCT01405079. Between Sept 19, 2011, and April 24, 2014, 483 patients were screened and 222 patients were randomised, 111 to gefitinib and 111 to vinorelbine plus cisplatin. Median follow-up was 36·5 months (IQR 23·8-44·8). Median disease-free survival was significantly longer with gefitinib (28·7 months [95% CI 24·9-32·5]) than with vinorelbine plus cisplatin (18·0 months [13·6-22·3]; hazard ratio [HR] 0·60, 95% CI 0·42-0·87; p=0·0054). In the safety population, the most commonly reported grade 3 or worse adverse events in the gefitinib group (n=106) were raised alanine aminotransferase and asparate

  1. 90Sr in fish inhabiting Ignalina NPP water cooling pond

    International Nuclear Information System (INIS)

    Dushauskiene - Duzh, R.

    1997-01-01

    The scope of this research was to investigate the way of the accumulation of 90 Sr in the tissues of fishes in the lake Drukshiai -cooling pond of Ignalina NPP, definition of its concentration and specificity of distribution . Research was carried out during 1994 - 1995. It was determined that the 90 Sr level in fish tissues and organs were formed by absorption and adsorption processes. More active were 90 Sr adsorption processes. 90 Sr concentration in skin with scales and gills reached 11.6±4.6 and 9.4±3.9 Bq/kg, respectively, while in fish organs and tissues it fluctuated from 1.2±0.35 (muscles) to 9.6±4.1 Bq/kg (digestion tract). The obtained data indicate that age, size and Ca concentration in fish are the main factors controlling the 90 Sr accumulation level in them. (author). 14 refs., 4 figs

  2. Geographical distribution of 90Sr contamination in Poland

    International Nuclear Information System (INIS)

    Gaca, P.; Mietelski, J.W.; Skwarzec, B.

    2006-01-01

    The paper presents results on determination of 90 Sr in bilberry and cowberry leaves (Vaccinium myrtillus and Vaccinium vitis-idaea) and the use of these plants as bio-monitors of radiostrontium contamination in Poland. Radiostrontium was determined by mean of liquid scintillation spectrometry preceded by radiochemical separation using Sr-resin and 85 Sr tracer. The approximate map of 90 Sr contamination of Poland is presented. The activity ratio between 90 Sr and obtained earlier data for 137 Cs in the same samples is discussed. The enhancement of radiostrontium content observed in northeastern Poland seems to be the trace of hot-particles fallout from initial Chernobyl cloud, which passed over Polish territory toward Scandinavia. (orig.)

  3. Resistance switching in epitaxial SrCoOx thin films

    Science.gov (United States)

    Tambunan, Octolia T.; Parwanta, Kadek J.; Acharya, Susant K.; Lee, Bo Wha; Jung, Chang Uk; Kim, Yeon Soo; Park, Bae Ho; Jeong, Huiseong; Park, Ji-Yong; Cho, Myung Rae; Park, Yun Daniel; Choi, Woo Seok; Kim, Dong-Wook; Jin, Hyunwoo; Lee, Suyoun; Song, Seul Ji; Kang, Sung-Jin; Kim, Miyoung; Hwang, Cheol Seong

    2014-08-01

    We observed bipolar switching behavior from an epitaxial strontium cobaltite film grown on a SrTiO3 (001) substrate. The crystal structure of strontium cobaltite has been known to undergo topotactic phase transformation between two distinct phases: insulating brownmillerite (SrCoO2.5) and conducting perovskite (SrCoO3-δ) depending on the oxygen content. The current-voltage characteristics of the strontium cobaltite film showed that it could have a reversible insulator-to-metal transition triggered by electrical bias voltage. We propose that the resistance switching in the SrCoOx thin film could be related to the topotactic phase transformation and the peculiar structure of SrCoO2.5.

  4. Resistance switching in epitaxial SrCoOx thin films

    International Nuclear Information System (INIS)

    Tambunan, Octolia T.; Parwanta, Kadek J.; Acharya, Susant K.; Lee, Bo Wha; Jung, Chang Uk; Kim, Yeon Soo; Park, Bae Ho; Jeong, Huiseong; Park, Ji-Yong; Cho, Myung Rae; Park, Yun Daniel; Choi, Woo Seok; Kim, Dong-Wook; Jin, Hyunwoo; Lee, Suyoun; Song, Seul Ji; Kang, Sung-Jin; Kim, Miyoung; Hwang, Cheol Seong

    2014-01-01

    We observed bipolar switching behavior from an epitaxial strontium cobaltite film grown on a SrTiO 3 (001) substrate. The crystal structure of strontium cobaltite has been known to undergo topotactic phase transformation between two distinct phases: insulating brownmillerite (SrCoO 2.5 ) and conducting perovskite (SrCoO 3−δ ) depending on the oxygen content. The current–voltage characteristics of the strontium cobaltite film showed that it could have a reversible insulator-to-metal transition triggered by electrical bias voltage. We propose that the resistance switching in the SrCoO x thin film could be related to the topotactic phase transformation and the peculiar structure of SrCoO 2.5

  5. Sr-90 determination in aqueous and soils samples

    International Nuclear Information System (INIS)

    Gonzalez Sintas, Maria F.; Cerchietti, Maria L.; Arguelles, Maria G.

    2009-01-01

    The main objective of this paper is to evaluate the method for Sr-90 determination in aqueous sample and soils. Area and Personal Dosimetry laboratory (DPA) determines the presence of Sr-90 by Liquid Scintillation (LSC) by applying method of the double window and corresponding adjustments. Calibration is performed by standard solutions of 90 Sr/ 90 Y, where spectral 90 Sr and 90 Y zones are optimized. The initial treatment of the liquid samples includes the concentration for evaporation, while the solid ones dissolve for microwave and acidic digestion. The separation of the analyte involves a selective chromatographic extraction. An average efficiency for 90 Sr of 77 ± 1 % was obtained; the factor a/b was 0,85 ± 0,01 and recovery of 82 ± 8 %. The resultant MAD was 0,10 Bq/L in aqueous samples and 0,10 Bq/g in solid samples. (author)

  6. Targeting SR-BI for cancer diagnostics, imaging and therapy

    Directory of Open Access Journals (Sweden)

    Maneesha Amrita Rajora

    2016-09-01

    Full Text Available Scavenger receptor class B type I (SR-BI plays an important role in trafficking cholesteryl esters between the core of high density lipoprotein and the liver. Interestingly, this integral membrane protein receptor is also implicated in the metabolism of cholesterol by cancer cells, whereby overexpression of SR-BI has been observed in a number of tumours and cancer cell lines, including breast and prostate cancers. Consequently, SR-BI has recently gained attention as a cancer biomarker and exciting target for the direct cytosolic delivery of therapeutic agents. This brief review highlights these key developments in SR-BI-targeted cancer therapies and imaging probes. Special attention is given to the exploration of high density lipoprotein nanomimetic platforms that take advantage of upregulated SR-BI expression to facilitate targeted drug-delivery and cancer diagnostics, and promising future directions in the development of these agents.

  7. Geographical distribution of {sup 90}Sr contamination in Poland

    Energy Technology Data Exchange (ETDEWEB)

    Gaca, P.; Mietelski, J.W. [The Henryk Niewodniczanski Inst. of Nuclear Physics (IFJ PAN), Krakow (Poland); Skwarzec, B. [Univ. of Gdansk, Dept. of Chemistry, Gdansk (Poland)

    2006-07-01

    The paper presents results on determination of {sup 90}Sr in bilberry and cowberry leaves (Vaccinium myrtillus and Vaccinium vitis-idaea) and the use of these plants as bio-monitors of radiostrontium contamination in Poland. Radiostrontium was determined by mean of liquid scintillation spectrometry preceded by radiochemical separation using Sr-resin and {sup 85}Sr tracer. The approximate map of {sup 90}Sr contamination of Poland is presented. The activity ratio between {sup 90}Sr and obtained earlier data for {sup 137}Cs in the same samples is discussed. The enhancement of radiostrontium content observed in northeastern Poland seems to be the trace of hot-particles fallout from initial Chernobyl cloud, which passed over Polish territory toward Scandinavia. (orig.)

  8. Experimental Evaluation of Characteristics of SR Motor Made of Permendur

    Science.gov (United States)

    Hasegawa, Yu; Nakamura, Kenji; Ichinokura, Osamu

    A switched reluctance (SR) motor has a doubly salient pole structure. The performance of the SR motor strongly depends on the magnetic properties of the core material since it consists only of an iron core and copper windings. This study experimentally evaluates the performance of an SR motor made of permendur (Fe-49%Co alloy), which has very high saturation flux density and low core loss. Two types of SR motors that have the same dimensions but different core materials are used: one motor is made of the conventional non-oriented Si steel, and the other is made of permendur. Comparison of the characteristics of the two motors shows that the performance of the permendur SR motor surpasses that of the conventional one in terms of output power and efficiency.

  9. MuSR Beam Line Design Studies

    Energy Technology Data Exchange (ETDEWEB)

    MacKay, W. W. [Weirich Consulting Services, Inc. Hunterville, NC (United States); Fischer, W. [Brookhaven National Lab. (BNL), Upton, NY (United States); Pile, P. [Brookhaven National Lab. (BNL), Upton, NY (United States); Blaskiewicz, M. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2013-12-13

    When a substance is implanted with positive muons the precession of their magnetic moments can be used to sample the magnetic properties of the material. The information obtained is complementary to that from NMR, ESR, and neutron scattering. To date, only four user facilities exist in the world but none in the US. We explore the possibility of using the AGS complex at BNL for a μSR facility for the production of positive surface muons. With an incident proton intensity of 1014 protons per second hitting a 200 mm long 0.5 mm thick graphite target, our preliminary design of the beam line could produce low momentum surface muons (24–30 MeV/c) with a flux of 0.9 MHz/cm2 for experiments.

  10. Expert Opinion in SR 97 and the SKI/SSI Joint Review of SR 97

    International Nuclear Information System (INIS)

    Hora, Stephen

    2002-09-01

    The role of sensitivity and uncertainty analyses for radioactive waste disposal assessments is reviewed. The report covers a description of the these concepts were applied in the authorities' review of the safety report SR 97. With regard to the use of expert knowledge, the most significant weakness of SR 97 is absence of any standards, procedures, and even definitions for expert judgment. This situation needs to be dealt with by SKB in the near future as it denigrates the portions of the study that are well done. In developing expert judgment processes, SSI should ensure that SKB creates procedures that guarantee traceability and transparency. This will become very important as the repository system matures and receives greater public scrutiny. Both in the area of scenario creation and expert judgement, there are processes that have gained international acceptance. It would be in the best interest of SKB, and the public, to adhere these accepted approaches

  11. Current situation of expeditious radiochemical 90Sr and 89Sr determination in environmental objects

    International Nuclear Information System (INIS)

    Kyrs, M.; Selucky, P.

    1991-12-01

    The compilation gives a survey of methods for 90 Sr and 89 Sr determination. Methods based on liquid scintillators and the Cherenkov radiation are enjoying progress. Precipitation processes are superseded by extraction methods, which contribute to rapidity of the analysis. Crowns (cyclic ethers) seem to be the most promising reagents for strontium separation. For the various measuring methods a large number exists of relations for the calculation of strontium activity. Brief information is presented on the occurrence and properties of strontium and its behavior in living organisms. Examples are given of the determination of radiostrontium in seawater, precipitations, in plants, teeth, milk, in mammal tissues and in soil. Sources of error and analytical quality assurance problems are discussed. (M.D.). 11 tabs., 136 refs

  12. Expert Opinion in SR 97 and the SKI/SSI Joint Review of SR 97

    Energy Technology Data Exchange (ETDEWEB)

    Hora, Stephen

    2002-09-01

    The role of sensitivity and uncertainty analyses for radioactive waste disposal assessments is reviewed. The report covers a description of the these concepts were applied in the authorities' review of the safety report SR 97. With regard to the use of expert knowledge, the most significant weakness of SR 97 is absence of any standards, procedures, and even definitions for expert judgment. This situation needs to be dealt with by SKB in the near future as it denigrates the portions of the study that are well done. In developing expert judgment processes, SSI should ensure that SKB creates procedures that guarantee traceability and transparency. This will become very important as the repository system matures and receives greater public scrutiny. Both in the area of scenario creation and expert judgement, there are processes that have gained international acceptance. It would be in the best interest of SKB, and the public, to adhere these accepted approaches.

  13. Determination of 89Sr and 90Sr in highly radioactive water from a nuclear power plant

    International Nuclear Information System (INIS)

    Bojanowski, R.; Radecki, Z.; Duniec, S.

    1994-01-01

    The main criterion in assaying strontium radionuclides is to obtain radiochemically pure strontium sources for beta-particle counting. Nuclear power plant waters contain both 89 Sr and 90 Sr accompanied by many beta-particle and gamma-ray emitting fission and neutron-activation products. The latter activities can sometimes exceed those of strontium by a factor of 10 7 . Efficient purification procedures must be used to remove these products, preferably at an initial stage of analysis to reduce the radiation risk to personnel. A method has been developed in which a water sample is passed through a prefilter installed on top of an ion-exchange column filled with Dowex-50 resin in H + form. This prefilter is impregnated with ferrocyanides and manganese dioxide and retains most of the interfering radionuclides while the underlying cation-exchanger takes up strontium ions. A few additional purification steps result in a strontium salt that is free from other radioactivity. (orig.)

  14. Variation in theAvrSr35gene determinesSr35resistance against wheat stem rust race Ug99.

    Science.gov (United States)

    Salcedo, Andres; Rutter, William; Wang, Shichen; Akhunova, Alina; Bolus, Stephen; Chao, Shiaoman; Anderson, Nickolas; De Soto, Monica Fernandez; Rouse, Matthew; Szabo, Les; Bowden, Robert L; Dubcovsky, Jorge; Akhunov, Eduard

    2017-12-22

    Puccinia graminis f. sp. tritici ( Pgt ) causes wheat stem rust, a devastating fungal disease. The Sr35 resistance gene confers immunity against this pathogen's most virulent races, including Ug99. We used comparative whole-genome sequencing of chemically mutagenized and natural Pgt isolates to identify a fungal gene named AvrSr35 that is required for Sr35 avirulence. The AvrSr35 gene encodes a secreted protein capable of interacting with Sr35 and triggering the immune response. We show that the origin of Pgt isolates virulent on Sr35 is associated with the nonfunctionalization of the AvrSr35 gene by the insertion of a mobile element. The discovery of AvrSr35 provides a new tool for Pgt surveillance, identification of host susceptibility targets, and characterization of the molecular determinants of immunity in wheat. Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

  15. Review of SKB's reporting of SR 97

    International Nuclear Information System (INIS)

    Tiren, S.A.

    2000-01-01

    The task of the safety assessment is to show 'that the repository has been designed with sufficient margins to be safe in spite of the incomplete knowledge available'. SKB mentions 'confidence in the results' as an important aspect. For the layman, confidence in the information presented is of the greatest importance. This means that the presentation of the safety assessment should be of a high visual standard with respect to descriptions of processes and events. SKB presented the purpose of SR 97 as four points. From a geological-structural geological viewpoint, the following can be mentioned: 1. Methodology for evaluating the geometry of the structural patterns of the bedrock at a depth of 500 m exists in general, but there are also certain deficiencies. Examples include determining the position of the individual structures and obtaining information. The importance of the bedrock is not completely clear. What is related to the rock type and what is related to the geological environment (including the geological evolution)? A clearer and more systematic compilation of data used in the safety assessment is required. 2. Work involving alternative models and evaluations of how well the models explain the collected data would be appropriate. The geological and structural models for a site are included as the base data in calculations and other modelling conducted in connection with the characterization of a site. 3. SR 97 does not provide any detailed information on site investigations. 4. The function of the bedrock as an external barrier is shown. However, to a certain extent, information on how this barrier can be affected by aseismic creep movements along fracture structures and the impact of selective erosion along such structures is lacking. Furthermore, criteria for properties of the rock volumes where deposition drifts are planned should be expanded, such as by determining a minimum width and suitable length-width relations

  16. Transgenerational isotopic marking of carp Cyprinus carpio, L. using a 86Sr /84Sr double spike

    Science.gov (United States)

    Zitek, Andreas; Cervicek, Magdalena; Irrgeher, Johanna; Horsky, Monika; Kletzl, Manfred; Weismann, Thomas; Prohaska, Thomas

    2013-04-01

    Transgenerational isotopic marking has been recognized recently as an effective tool for mass marking and tracking of individual fish to their original source. Compared to other conventional marking techniques, transgenerational marking offers several advantages. Most importantly, it is possible to mark all offspring of one individual female without the necessity of handling eggs or larval fish. Furthermore it is possible to vary the concentrations of individual isotopes to obtain specific marks for individual female fish. An enriched isotopic spike solution is usually applied to gravid female spawners by injection into the body cavity for transgenerational marking. The isotope is then incorporated into the central otolith region of the offspring which is known to be built up by maternally derived material. Within this study transgenerational marking of a typical cyprinid fish species, Cyprinus carpio, L., was tested using a 86Sr /84Sr double spike. Buffered solutions with different isotopic composition and concentrations were administered to 4 female individuals by intraperitoneal injection 5 days before spawning, while one female was injected a blank solution. After spawning, otoliths (Lapilli) from juvenile fish were sampled at the age of about 5 months at fish sizes between 3 and 4 cm and analyzed for their isotopic composition by LA-ICPMS applying cross sectional line scans. Central otolith regions of the progeny showed a shift in the natural isotope ratios for the administered isotopes. Deconvolution of the blank corrected measurement data of the Sr isotopes was done to trace back the original spike ratio. The different spike ratios could be well distinguished reflecting the original composition of the spike solution. This study proved that it is possible to create batch-specific unique transgenerational marks in otolith cores by varying the concentrations of two naturally occurring Sr isotopes. This method has high potential to reduce the marking effort for

  17. Applicability of 87Sr/86Sr in examining return flow of irrigation water in highly agricultural watersheds in Japan

    Science.gov (United States)

    Yoshida, T.; Nakano, T.; Shin, K. C.; Tsuchihara, T.; Miyazu, S.; Kubota, T.

    2017-12-01

    Water flows in watersheds containing extensive areas of irrigated paddies are complex because of the substantial volumes involved and the repeated cycles of water diversion from, and return to, streams. For better management of low-flow conditions, numerous studies have attempted to quantify the return flow using the stable isotopes of water; however, the temporal variation in these isotopic compositions due to fractionation during evaporation from water surfaces hinders their application to watersheds with extensive irrigated paddies. In this study, we tested the applicability of the strontium isotopes (87Sr/86Sr, hereafter Sr ratio) for studying hydrological processes in a typical agricultural watershed located on the alluvial fan of the Kinu River, namely the Gogyo River, in central Japan. The Sr ratio of water changes only because of interactions with the porous media it flows through, or because of mixing with water that has different Sr ratios. We sampled water both at a single rice paddy, and on the watershed scale in the irrigated and non-irrigated periods. The soil water under the paddy decreased as sampling depth increased, and the soil water at a depth of 1.5 m showed a similar Sr ratio to the spring. The water sampled in the drainage channel with a concrete lined bottom showed a similar Sr ratio to the irrigation water, whereas that with a soil bottom was plotted between the plots of the irrigation water and shallow aquifer. These results suggest the Sr ratio decreases as it mixes with the soil water through percolation; whereas the Sr ratio will be less likely to change when water drains from paddies via surface pathways. The streamflow samples were plotted linearly on the Sr ratio and 1/Sr plot, indicating that the streamflow was composed of two end-members; the irrigation water and the shallow aquifer. The continuous decline in the Sr ratio along the stream suggests an exfiltration of water from the shallow aquifers. The stream water during the non

  18. Interactions of SR45, an SR-like protein, with spliceosomal proteins and an intronic sequence: insights into regulated splicing.

    Science.gov (United States)

    Day, Irene S; Golovkin, Maxim; Palusa, Saiprasad G; Link, Alicia; Ali, Gul S; Thomas, Julie; Richardson, Dale N; Reddy, Anireddy S N

    2012-09-01

    SR45 is a serine/arginine-rich (SR)-like protein with two arginine/serine-rich (RS) domains. We have previously shown that SR45 regulates alternative splicing (AS) by differential selection of 5' and 3' splice sites. However, it is unknown how SR45 regulates AS. To gain mechanistic insights into the roles of SR45 in splicing, we screened a yeast two-hybrid library with SR45. This screening resulted in the isolation of two spliceosomal proteins, U1-70K and U2AF(35) b that are known to function in 5' and 3' splice site selection, respectively. This screen not only confirmed our prior observation that U1-70K and SR45 interact, but also helped to identify an additional interacting partner (U2AF(35) ). In vitro and in vivo analyses revealed an interaction of SR45 with both paralogs of U2AF(35) . Furthermore, we show that the RS1 and RS2 domains of SR45, and not the RNA recognition motif (RRM) domain, associate independently with both U2AF(35) proteins. Interaction studies among U2AF(35) paralogs and between U2AF(35) and U1-70K revealed that U2AF(35) can form homo- or heterodimers and that U2AF(35) proteins can associate with U1-70K. Using RNA probes from SR30 intron 10, whose splicing is altered in the sr45 mutant, we show that SR45 and U2AF(35) b bind to different parts of the intron, with a binding site for SR45 in the 5' region and two binding regions, each ending with a known 3' splice site, for U2AF(35) b. These results suggest that SR45 recruits U1snRNP and U2AF to 5' and 3' splice sites, respectively, by interacting with pre-mRNA, U1-70K and U2AF(35) and modulates AS. © 2012 The Authors. The Plant Journal © 2012 Blackwell Publishing Ltd.

  19. Rare earth elements and (87)Sr/(86)Sr isotopic characterization of Indian Basmati rice as potential tool for its geographical authenticity.

    Science.gov (United States)

    Lagad, Rupali A; Singh, Sunil K; Rai, Vinai K

    2017-02-15

    The increasing demand for premium priced Indian Basmati rice (Oryza sativa) in world commodity market causing fraudulent activities like adulteration, mislabelling. In order to develop authentication method for Indian Basmati rice, (87)Sr/(86)Sr ratios and REEs composition of Basmati rice, soil and water samples were determined and evaluated their ability as geographical tracer in the present study. In addition, the possible source of Sr in rice plant has also been examined. Basmati rice samples (n=82) showed (87)Sr/(86)Sr ratios in the range 0.71143-0.73448 and concentrations of 10 REEs (La, Ce, Pr, Nd, Sm, Eu, Gd, Dy, Er, Yb) in ppb levels. Statistical analysis showed strong correlation between (87)Sr/(86)Sr ratios of rice, silicate and carbonate fractions of soil. Good correlation and closeness of (87)Sr/(86)Sr of rice with water indicate its uptake in rice from water. Rice grown in southern Uttar Pradesh contains higher (87)Sr/(86)Sr compared to other region of Indo-Gangetic Plain due to higher (87)Sr/(86)Sr of the Ganga compared to other rivers. (87)Sr/(86)Sr ratios can be used as a tracer for differentiating Indian Basmati rice from the other country originated rice samples. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. Interim FEP report for the safety assessment SR-Can

    International Nuclear Information System (INIS)

    Skagius, Kristina

    2004-08-01

    This report describes the work with identification and structuring of features, events and processes (FEPs) that has been carried out within the scope of the SR-Can safety assessment up to the time of the interim reporting of the project. The overall objective of the work is to develop a database of features, events and processes in a format that would facilitate both a systematic analysis of FEPs and documentation of the FEP analysis as well as facilitate revisions and updates to be made in connection with new safety assessments. This overall objective also includes the development of procedures for a systematic FEP analysis as well as to apply these procedures in order to arrive at an SR-Can version of the FEP database. The work started by implementing the content of the SR 97 Process report into a database format suitable for import and processing of FEP information from other sources. The SR 97 version of the database was systematically audited against the NEA database with Project FEPs, version 1.2. In addition, an earlier audit of the SR 97 process report against the interaction matrices developed for a deep repository of the KBS-3 type was revisited and updated. Relevant FEPs from the audit were sorted into three main categories in the SR-Can database i) FEPs related to the initial states of the repository system, ii) FEPs related to internal processes of the repository system, and iii) FEPs related to external impacts on the repository system. These groups of FEPs were further processed for making decisions on how to handle these FEPs in the assessment. Biosphere processes were not included in the SR 97 Process report and there is thus not the same basis for updating these descriptions as for the engineered barriers and the geosphere. All biosphere FEPs from the audit have therefore been compiled in a single category in the database, but remain to be further handled. FEPs were also categorised as irrelevant or as being related to methodology on a general

  1. 90Sr- 90Y and 89Sr beta radioactivity measurement in milk samples using a proportional counter

    International Nuclear Information System (INIS)

    Mananes, A.; Perez Santos, C.; Martinez Churiaque, F.

    1987-01-01

    A thin window glas flow proportional counter is used to measure the 90 Sr- 90 Y and 89 Sr beta radioactivity in milk samples. A chemical procedure is used to separate strontium-yttrium from the other radionuclides present in milk. A calculation of the total efficiency of the system is performed which includes an empirical estimation of the backscattering factor. The calibration of the whole process allows the determination of the 90 Sr activity within 10% relative error in spite of uncertainties in the recovery yields of strontium and yttrium. No 89 Sr activity has been detected, and the mean value obtained for the 90 Sr activity in nine milk samples of Cantabria is 0.115 Bq/1 with a minimum detectable activity of 0.0105 Bq. (author) 18 refs

  2. Effect of Sr/Ti Ratio on the Photocatalytic Properties of SrTiO{sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Sulaeman, U; Yin, S [Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1, Katahira, Aoba-ku, Sendai 980-8577 (Japan); Sato, T, E-mail: tsusato@tagen.tohoku.ac.jp

    2011-10-29

    Since strontium titanate is a wide gap semiconductor, it requires UV light to generate the photocatalytic activities. Modification of strontium titanate to show photocatalytic activity under visible light irradiation is the essential work to efficiently utilize the sun light energy for environmental application. It is expected that the synthesis of SrTiO{sub 3} with variation of Sr/Ti atomic ratio could induce the defect crystals having unique photocatalytic properties. The SrTiO{sub 3} with various Sr/Ti atomic ratios were synthesized by microwave-assisted solvothermal reaction of SrCl{sub 2}.6H{sub 2}O and Ti(OC{sub 3}H{sub 7}){sub 4} in KOH aqueous solutions with different atomic ratios of Sr/Ti. The products were characterized by TG-DTA, XRD and DRS. The photocatalytic activity was determined by DeNO{sub x} ability using LED lamps with the wavelengths of 627 nm (red), 530 nm (green), 445 nm (blue) and 390 nm (UV). The nanoparticles of perovskite type SrTiO{sub 3} with the particle size of 30-40 nm were successfully synthesized. The visible light responsive photocatalytic activity was generated by adding excess amount of Sr. The photocatalytic activity in visible light could be enhanced by an increase in the Sr/Ti atomic ratio up to 1.25, indicating that the visible light responsive photocatalytic activity is due to the generation of new band gap between the conduction band and valence band of SrTiO{sub 3} by the formation of oxygen vacancy.

  3. Adsorption behavior of 90Sr on montmorillonite or vermiculite

    International Nuclear Information System (INIS)

    Liao Jiali; Li Bing; Wu Jiaojiao; Yang Yuanyou; Liu Ning; Zhang Dong; Zhao Jun; Cheng Qiong

    2008-01-01

    The adsorption of 90 Sr from aqueous solution by montmorillonite or vermiculite, and the effect of experimental conditions on the adsorption were investigated. The preliminary results showed that montmorillonite and vermiculite were both efficient absorbent for 90 Sr and more than 96% or 98% of the total 90 Sr could be removed by montmorillonite or vermiculite of 20 g/L from 90 Sr solution of 20 kBq/L(Co). The adsorption equilibrium was achieved within 30 min and 2h, and the suitable pH ranged 2-12 and 3-12. No significant differences on 90 Sr adsorption were observed at 0-50℃ by these two natural absorbents. In this time, the adsorption rate decreased with the increase of 90 Sr concentration in the range of 1-200 kBq/L and the adsorption behavior accorded to Langmuir isothermal adsorption. Furthermore, the adsorption rate both increased efficiently on montmorillonite and vermiculite modified by 1-2 mol/L HCl. About 98% of adsorbed 90 Sr could be desorbed by 10 mL of 2 mol/L HNO 3 . (authors)

  4. Deposition of 90Sr in bone and the relevant dose

    International Nuclear Information System (INIS)

    Kawamura, Hisao

    1976-01-01

    The deposition of fallout 90 Sr in bone and radiation dose from the nuclide in Japan is reviewed with special reference to (i) the intraskeletal distribution of 90 Sr and reference bone, (ii) bone models for predicting 90 Sr level and (iii) possible problems in applying dose rate factors to Japanese, especially to infants and adolescents. An evidence is presented for the assumption that the ratio of the 90 Sr concentration in a particular bone to that in vertebra will reach the ratio observed for stable strontium under the virtually constant intake of 90 Sr. The importance of surveying 90 Sr levels in different bones is stressed. Observed Ratios (bone/diet) found for Japanese are noticeably lower than those reported for Europeans and Americans. The recently presented model for the retention of alkaline earth elements in man by ICRP will be useful if only adults are concerned. Dose rate factors for 90 Sr in bone should be given as a function of age for the purpose of better estimation of dose commitments. The cumulative absorbed doses to bone tissues calculated with the Palmley-Mays model and with the Spiers model show remarkably higher levels in school children and young adults than the mean level. (auth.)

  5. PRODUCTION OF PLANTARCIN BY LACTOBACILLUS PLANTARUM SR18

    Directory of Open Access Journals (Sweden)

    Wagih El-Shouny

    2012-06-01

    Full Text Available Out of 86 lactobacilli previously screened in our laboratory, Lactobacillus plantarum SR18 isolated from yoghurt revealed the largest detected inhibition zone against the selected indicator Streptococcus salivarius 5. The obtained electrophoretic patterns revealed that L. plantarum SR18 was free from plasmids. Exposure of 6 h growing L. plantarum culture to T-8M, 3B ultraviolet B lamp (8w, 220v & 312 nm for 2 h and subsequent growth for further 24 h resulted in an increase of cell-bound bacteriocin titer reached 2 fold at 12 h. Whereas bacteriocin secreted in the culture filtrate was not affected by UV irradiation. Plantarcin SR18 production was maximal (12800 AU/ml between 12 and 18 h by incubation of the culture at 37°C and pH 5-7 in candle jar (CO2. The bacteriocin bound to the cells and that secreted into the culture filtrate of L. plantarum SR18 were precipitated by 75% ammomium sulphate, dialysed and further purified by Gel filtration on Sephadex G-100. The specific activities (AU/mg protein were increased by a factor of about 5.3 and 2.35 for plantarcins purified from proteins bound to the cell of L. plantarum SR18 (plantarcin SR18 a and that secreted into the culture filtrate (plantarcin SR18 b, respectively. Gel filtration of plantarcin SR18a resulted in moderate antibacterial activity (3200 AU/ml and very high activity (25600 AU/ml of plantarcin SR18b.

  6. Nuclear safety activities in the SR of Slovenia in 1986

    International Nuclear Information System (INIS)

    Susnik, J.

    1987-06-01

    Currently Yugoslavia has one 632 MWe nuclear power plant (NPP) of PWR design, located at Krsko in the Socialist Republic (SR) of Slovenia. Krsko NPP, which is a two-loop plant, started power operation in 1981. In general, reactor safety activities in the SR of Slovenia are mostly related to upgrading the safety of our Krsko NPP and to developing capabilities for use in future units. This report presents the nuclear safety related legislation and organization of the corresponding regulatory body, and the activities related to nuclear safety of the participating organizations in the SR of Slovenia in 1986. (author)

  7. OpenNebula KVM SR-IOV driver

    CSIR Research Space (South Africa)

    Macleod, D

    2013-05-01

    Full Text Available Version: 0.1 License: Apache 2.0 Web Links: Project Website: http://wiki.chpc.ac.za/acelab:opennebula_sr-iov_vmm_driver Demonstration Video: http://www.youtube.com/watch?v=wB-Z1o2jGaY OpenNebula Page: http...://opennebula.org/software:ecosystem:sr-iov Prerequisites and Limitations 1. This driver has been developed to support OpenNebula 4.0 and KVM. The driver should be backwards compatible the OpenNebula 3.x. 2. SR-IOV capable hardware and software is required. Before using...

  8. THE DETERMINATION OF 89SR ACTIVITY IN OBJECTS OF ENVIRONMENT

    Directory of Open Access Journals (Sweden)

    O. N. Prokof 'ev

    2010-01-01

    Full Text Available The radionuclide 89Sr give considerable contribution in the composition of fission products, which get in environment due to an accident of nuclear reactor or due to conducting of peaceful nuclear explosion. By radiation characteristics this radionuclide essentially differs from 90Sr. Due to its shorter half period it faster leaves the objects of environment and therefore represents less radiation hazard for man than 90Sr. These radionuclides belong to the same element of chemical system and therefore are difficulty separated with the use of chemical methods. The work offers an approach, which joins chemical and radioactive methods.

  9. Lacustrine 87Sr/86Sr as a tracer to reconstruct Milankovitch forcing of the Eocene hydrologic cycle

    Science.gov (United States)

    Baddouh, M'bark; Meyers, Stephen R.; Carroll, Alan R.; Beard, Brian L.; Johnson, Clark M.

    2016-08-01

    The Green River Formation (GRF) provides one of the premier paleoclimate archives of the Early Eocene Climatic Optimum (∼50 Ma), representing the apex of the early Cenozoic greenhouse climate. Rhythmic lake-level variability expressed in the GRF has inspired numerous hypotheses for the behavior of the Eocene hydrologic cycle, including its linkage to astronomical forcing, solar variability, and the El Niño Southern Oscillation (ENSO). However, the lack of sufficient proxy data to document atmospheric water-mass transport and the geographic pattern of evaporation/precipitation/runoff has made it difficult to discriminate between different models for astronomical forcing. Variable 87Sr/86Sr ratios of bedrock that encompass the GRF provide an opportunity to reconstruct the spatial expression of the Eocene hydrologic cycle and its linkage to lake level. Here Sr isotope data from the Wilkins Peak Member, a rhythmic succession that has been demonstrated to record Milankovitch forcing of lake levels, indicate that high lake levels reflect an increased proportion of runoff from less radiogenic rocks west of the basin, eliminating a number of the existing astronomical-forcing hypotheses. The 87Sr/86Sr variability is consistent with a change in mean ENSO state, which is predicted by climate models to be linked to orbital-insolation. Thus, the 87Sr/86Sr data reveal a coupling of high frequency (ENSO) and low frequency (astronomical) climate variability, and also predict the existence of sizable astronomically-forced alpine snowpack during the last greenhouse climate. More broadly, this study demonstrates the utility of 87Sr/86Sr as a powerful tool for reconstructing the deep-time hydrologic cycle.

  10. Solar Thermochemical Energy Storage Through Carbonation Cycles of SrCO3/SrO Supported on SrZrO3.

    Science.gov (United States)

    Rhodes, Nathan R; Barde, Amey; Randhir, Kelvin; Li, Like; Hahn, David W; Mei, Renwei; Klausner, James F; AuYeung, Nick

    2015-11-01

    Solar thermochemical energy storage has enormous potential for enabling cost-effective concentrated solar power (CSP). A thermochemical storage system based on a SrO/SrCO3 carbonation cycle offers the ability to store and release high temperature (≈1200 °C) heat. The energy density of SrCO3/SrO systems supported by zirconia-based sintering inhibitors was investigated for 15 cycles of exothermic carbonation at 1150 °C followed by decomposition at 1235 °C. A sample with 40 wt % of SrO supported by yttria-stabilized zirconia (YSZ) shows good energy storage stability at 1450 MJ m(-3) over fifteen cycles at the same cycling temperatures. After further testing over 45 cycles, a decrease in energy storage capacity to 1260 MJ m(-3) is observed during the final cycle. The decrease is due to slowing carbonation kinetics, and the original value of energy density may be obtained by lengthening the carbonation steps. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma cells.

    Directory of Open Access Journals (Sweden)

    Yue Ma

    Full Text Available The inverse F-BAR (IF-BAR domain proteins srGAP1, srGAP2 and srGAP3 are implicated in neuronal development and may be linked to mental retardation, schizophrenia and seizure. A partially overlapping expression pattern and highly similar protein structures indicate a functional redundancy of srGAPs in neuronal development. Our previous study suggests that srGAP3 negatively regulates neuronal differentiation in a Rac1-dependent manner in mouse Neuro2a cells. Here we show that exogenously expressed srGAP1 and srGAP2 are sufficient to inhibit valporic acid (VPA-induced neurite initiation and growth in the mouse Neuro2a cells. While ectopic- or over-expression of RhoGAP-defective mutants, srGAP1(R542A and srGAP2(R527A exert a visible inhibitory effect on neuronal differentiation. Unexpectedly, knockdown of endogenous srGAP2 fails to facilitate the neuronal differentiation induced by VPA, but promotes neurite outgrowth of differentiated cells. All three IF-BAR domains from srGAP1-3 can induce filopodia formation in Neuro2a, but the isolated IF-BAR domain from srGAP2, not from srGAP1 and srGAP3, can promote VPA-induced neurite initiation and neuronal differentiation. We identify biochemical and functional interactions of the three srGAPs family members. We propose that srGAP3-Rac1 signaling may be required for the effect of srGAP1 and srGAP2 on attenuating neuronal differentiation. Furthermore, inhibition of Slit-Robo interaction can phenocopy a loss-of-function of srGAP3, indicating that srGAP3 may be dedicated to the Slit-Robo pathway. Our results demonstrate the interplay between srGAP1, srGAP2 and srGAP3 regulates neuronal differentiation and neurite outgrowth. These findings may provide us new insights into the possible roles of srGAPs in neuronal development and a potential mechanism for neurodevelopmental diseases.

  12. ACTH Regulation of Adrenal SR-B1

    Directory of Open Access Journals (Sweden)

    Wen-Jun eShen

    2016-05-01

    Full Text Available The adrenal gland is one of the prominent sites for steroid hormone synthesis. Lipoprotein-derived cholesterol esters delivered via scavenger receptor, class B type 1 (SR-B1 constitute the dominant source of cholesterol for steroidogenesis, particularly in rodents. ACTH stimulates steroidogenesis through downstream actions on multiple components involved in steroidogenesis. Both acute and chronic ACTH treatment can modulate SR-B1 function including its transcription, its post transcriptional stability, its phosphorylation and dimerization status, as well as its interaction with other protein partners; all of which result in changes in the ability of SR-B1 to mediate HDL-cholesterol ester uptake and the supply of cholesterol for conversion to steroids. Here we provide a review of the recent findings on the regulation of adrenal SR-B1 function by ACTH.

  13. Off-Label Use of Crizotinib as a Neoadjuvant Treatment for a Young Patient When Conventional Chemotherapy Gave No Benefits in Stage IIIA Non-Small Cell Lung Cancer.

    Science.gov (United States)

    Dumont, Delphine; Dô, Pascal; Lerouge, Delphine; Planchard, Gaëtane; Riffet, Marc; Dubos-Arvis, Catherine; Danhier, Serge; Gervais, Radj

    2017-08-15

    BACKGROUND The treatment of locally advanced non-small cell lung cancer involves a combination of chemotherapy, surgery, and radiotherapy. Each case is discussed and the best strategy is chosen individually, following international guidelines. CASE REPORT A 37-year-old man was diagnosed with locally advanced broncho-pulmonary adenocarcinoma (stage IIIA). The disease was stable after 2 cycles of cisplatin plus Navelbine used as neoadjuvant therapy. FISH analysis revealed an ALK rearrangement. The patient then received unlicensed crizotinib as second-line neoadjuvant treatment, which led to an almost complete radiological and metabolic response. A left upper lobectomy was performed, followed by post-operative chemotherapy and radiotherapy. At 18 months post-surgery, the patient is still disease-free according to the last CT scan. CONCLUSIONS Targeted therapy was an alternative solution when chemotherapy was not helping. Randomized studies are needed to define its precise role in the neoadjuvant scheme.

  14. ST-segment resolution with bivalirudin versus heparin and routine glycoprotein IIb/IIIa inhibitors started in the ambulance in ST-segment elevation myocardial infarction patients transported for primary percutaneous coronary intervention

    DEFF Research Database (Denmark)

    Van't Hof, Arnoud; Giannini, Francesco; Ten Berg, Jurrien

    2017-01-01

    resolution either before or after the index procedure. CONCLUSIONS: Pre-hospital treatment with bivalirudin is non-inferior to pre-hospital heparin + GPI with regard to residual ST-segment deviation or ST-segment resolution, reflecting comparable myocardial reperfusion with the two strategies.......BACKGROUND: Myocardial reperfusion after primary percutaneous coronary intervention (PCI) can be assessed by the extent of post-procedural ST-segment resolution. The European Ambulance Acute Coronary Syndrome Angiography (EUROMAX) trial compared pre-hospital bivalirudin and pre-hospital heparin...... or enoxaparin with or without GPIIb/IIIa inhibitors (GPIs) in primary PCI. This nested substudy was performed in centres routinely using pre-hospital GPI in order to compare the impact of randomized treatments on ST-resolution after primary PCI. METHODS: Residual cumulative ST-segment deviation on the single...

  15. Thermodynamically stable diatomic dications: The cases of SrO2+ and SrH2+

    Science.gov (United States)

    Gonçalves dos Santos, Levi; Franzreb, Klaus; Ornellas, Fernando R.

    2018-03-01

    A high level theoretical investigation of the low-lying electronic states of the diatomic dications SrO2+ and SrH2+ is presented for the first time along with experimental results of their mass spectra where they were detected. A global and reliable picture of the potential energy curves of the electronic states and the associated spectroscopic parameters provide quantitative results attesting to the thermodynamic stability of both species. Inclusion of spin-orbit interactions does not significantly change the energetic characterization. For SrO2+, the ground (X 3Σ-) and first excited (A 3Π, Te = 3971 cm-1) states are bound (De) by 15.94 kcal mol-1 and 4.71 kcal mol-1, respectively. Transition probabilities (Av'v″) have been evaluated and radiative lifetimes estimated for the vibrational states of A 3Π (v'), and transition probabilities are expected to be diagonally dominant and fall in the far-IR region of the spectrum. For the singlet states a 1Δ, b 1Π, c 1Σ+, and d 1Σ+, transition probabilities have also been calculated for all symmetry allowed transitions and the radiative lifetimes evaluated for selected vibrational states of the upper levels. The transitions associated with the band systems d 1Σ+-b 1Π and d 1Σ+-c 1Σ+, although falling in the yellow region of the spectrum, with overlapping bands, are expected to show quite distinct intensities since the transition moment associated with d 1Σ+-c 1Σ+ is much larger. For singlet transitions, the prediction of relative intensities using the Franck-Condon approximation fails in most of the cases. For SrH2+, only the ground state is bound (De = 6.54 kcal mol-1); with an equilibrium distance of 5.117 a0, the associated spectroscopic parameters (ωe, ωexe, Be) turned out to be (518.9, 32.77, 2.3227) in cm-1. For both species, dipole moment functions illustrate the variation of the molecular polarity with the internuclear distance.

  16. The impact of Mg contents on Sr partitioning in benthic foraminifers

    NARCIS (Netherlands)

    Mewes, A.; Langer, G.; Reichart, G.-J.; de Nooijer, L.J.; Nehrke, G.; Bijma, J.

    2015-01-01

    Foraminiferal calcite Mg/Ca (Mg/CaCC) is used in paleoceanographic studies to reconstruct temperature. Furthermore, the Mg/CaCC is influenced by different seawater Mg/Ca (Mg/CaSW). Foraminiferal calcite Sr/Ca (Sr/CaCC) can potentially be used to reconstruct Sr/Ca ratios of seawater (Sr/CaSW). As

  17. Precessional control of Sr ratios in marginal basins during the Messinian Salinity Crisis?

    NARCIS (Netherlands)

    Topper, R.P.M.; Lugli, S.; Manzi, V.; Roveri, M.; Meijer, P.Th.

    Based on 87Sr/86Sr data of the Primary Lower Gypsum (PLG) deposits in the Vena del Gesso basin—a marginal basin of the Mediterranean during the Messinian Salinity Crisis—a correlation between 87Sr/86Sr values and precessional forcing has recently been proposed but not yet confirmed. In this study, a

  18. The Crystal Structure of SrCrO4

    DEFF Research Database (Denmark)

    Berg, Rolf W.

    1996-01-01

    X-ray diffraction diagrams taken with Cu-K(alpha) radiation in a Bragg-Brentano diffractometer have shown that the La0.8Sr0.2CrO3 powders, synthesized by drip/spray pyrolysis in a rotating tube furnace at 600-700 oC, contained SrCrO4, in addition to the ceramic perovskite phase. By means...

  19. Interim process report for the safety assessment SR-Can

    Energy Technology Data Exchange (ETDEWEB)

    Sellin, Patrick (ed.)

    2004-08-01

    This report is a documentation of buffer processes identified as relevant to the long-term safety of a KBS-3 repository. The report is part of the interim reporting of the safety assessment SR-Can, see further the Interim main report. The final SR-Can reporting will support SKB's application to build an Encapsulation plant for spent nuclear fuel and is to be produced in 2006. The purpose of this report is to document the scientific knowledge of the processes to a level required for an adequate treatment in the safety assessment. The documentation is thus from a scientific point of not exhaustive since such a treatment is neither necessary for the purposes of the safety assessment nor possible within the scope of an assessment. The purpose is further to determine the handling of each process in the safety assessment and to demonstrate how uncertainties are taken care of, given the suggested handling. The process documentation in the SR 97 version of the Process report is a starting point for this SR-Can interim version. As further described in the Interim main report, the list of relevant processes has been reviewed and slightly extended by comparison to other databases. Furthermore, the backfill has been included as a system part of its own, rather than being described together with the buffer as in SR 97. Apart from giving an interim account of the documentation and handling of buffer processes in SR-Can, this report is meant to serve as a template for the forthcoming documentation of processes occurring in other parts of the repository system. A complete list of processes can be found in the Interim FEP report for the safety assessment SR-Can. All material presented in this document is preliminary in nature and will possibly be updated as the SR-Can project progresses.

  20. Interim process report for the safety assessment SR-Can

    International Nuclear Information System (INIS)

    Sellin, Patrick

    2004-08-01

    This report is a documentation of buffer processes identified as relevant to the long-term safety of a KBS-3 repository. The report is part of the interim reporting of the safety assessment SR-Can, see further the Interim main report. The final SR-Can reporting will support SKB's application to build an Encapsulation plant for spent nuclear fuel and is to be produced in 2006. The purpose of this report is to document the scientific knowledge of the processes to a level required for an adequate treatment in the safety assessment. The documentation is thus from a scientific point of not exhaustive since such a treatment is neither necessary for the purposes of the safety assessment nor possible within the scope of an assessment. The purpose is further to determine the handling of each process in the safety assessment and to demonstrate how uncertainties are taken care of, given the suggested handling. The process documentation in the SR 97 version of the Process report is a starting point for this SR-Can interim version. As further described in the Interim main report, the list of relevant processes has been reviewed and slightly extended by comparison to other databases. Furthermore, the backfill has been included as a system part of its own, rather than being described together with the buffer as in SR 97. Apart from giving an interim account of the documentation and handling of buffer processes in SR-Can, this report is meant to serve as a template for the forthcoming documentation of processes occurring in other parts of the repository system. A complete list of processes can be found in the Interim FEP report for the safety assessment SR-Can. All material presented in this document is preliminary in nature and will possibly be updated as the SR-Can project progresses

  1. Alginate prevention of internal irradiation with 90Sr

    International Nuclear Information System (INIS)

    Korzun, V.N.; Voronova, Yu.G.; Parats, A.N.; Podkorytova, A.V.; Rogal'skaya, L.A.; Saglo, V.I.; Skorikova, A.I.

    1992-01-01

    Recipes of foodstaffs (meat and vegetable preserves, bread, pastry, dairy products, etc.) containing sodium or calcium alginates in doses 0.5-3.0 g have been developed. Experiments with white rats have demonstrated that addition of such products to daily radions of these animals reduced 2-4-fold the accumulation of radioactive Sr taken daily with food for 30 days. Alginates and Crambe added to food preserve their ability to reduce the accumulation of radioactive Sr

  2. Adjuvant Systemic Therapy and Adjuvant Radiation Therapy for Stage I to IIIA Completely Resected Non-Small-Cell Lung Cancers: American Society of Clinical Oncology/Cancer Care Ontario Clinical Practice Guideline Update.

    Science.gov (United States)

    Kris, Mark G; Gaspar, Laurie E; Chaft, Jamie E; Kennedy, Erin B; Azzoli, Christopher G; Ellis, Peter M; Lin, Steven H; Pass, Harvey I; Seth, Rahul; Shepherd, Frances A; Spigel, David R; Strawn, John R; Ung, Yee C; Weyant, Michael

    2017-09-01

    Purpose The panel updated the American Society of Clinical Oncology (ASCO) adjuvant therapy guideline for resected non-small-cell lung cancers. Methods ASCO convened an update panel and conducted a systematic review of the literature, investigating adjuvant therapy in resected non-small-cell lung cancers. Results The updated evidence base covered questions related to adjuvant systemic therapy and included a systematic review conducted by Cancer Care Ontario current to January 2016. A recent American Society for Radiation Oncology guideline and systematic review, previously endorsed by ASCO, was used as the basis for recommendations for adjuvant radiation therapy. An update of these systematic reviews and a search for studies related to radiation therapy found no additional randomized controlled trials. Recommendations Adjuvant cisplatin-based chemotherapy is recommended for routine use in patients with stage IIA, IIB, or IIIA disease who have undergone complete surgical resections. For individuals with stage IB, adjuvant cisplatin-based chemotherapy is not recommended for routine use. However, a postoperative multimodality evaluation, including a consultation with a medical oncologist, is recommended to assess benefits and risks of adjuvant chemotherapy for each patient. The guideline provides information on factors other than stage to consider when making a recommendation for adjuvant chemotherapy, including tumor size, histopathologic features, and genetic alterations. Adjuvant chemotherapy is not recommended for patients with stage IA disease. Adjuvant radiation therapy is not recommended for patients with resected stage I or II disease. In patients with stage IIIA N2 disease, adjuvant radiation therapy is not recommended for routine use. However, a postoperative multimodality evaluation, including a consultation with a radiation oncologist, is recommended to assess benefits and risks of adjuvant radiation therapy for each patient with N2 disease. Additional

  3. Decoupling of unpolluted temperate forests from rock nutrient sources revealed by natural 87Sr/86Sr and 84Sr tracer addition

    Science.gov (United States)

    Kennedy, Martin J.; Hedin, Lars O.; Derry, Louis A.

    2002-01-01

    An experimental tracer addition of 84Sr to an unpolluted temperate forest site in southern Chile, as well as the natural variation of 87Sr/86Sr within plants and soils, indicates that mechanisms in shallow soil organic horizons are of key importance for retaining and recycling atmospheric cation inputs at scales of decades or less. The dominant tree species Nothofagus nitida feeds nearly exclusively (>90%) on cations of atmospheric origin, despite strong variations in tree size and location in the forest landscape. Our results illustrate that (i) unpolluted temperate forests can become nutritionally decoupled from deeper weathering processes, virtually functioning as atmospherically fed ecosystems, and (ii) base cation turnover times are considerably more rapid than previously recognized in the plant available pool of soil. These results challenge the prevalent paradigm that plants largely feed on rock-derived cations and have important implications for understanding sensitivity of forests to air pollution. PMID:12119394

  4. FEP report for the safety assessment SR-Can

    Energy Technology Data Exchange (ETDEWEB)

    Skagius, Kristina [Kemakta Konsult AB, Stockholm (Sweden)

    2006-11-15

    This report documents the analysis and processing of features, events and processes, FEPs, that has been carried out within the safety assessment SR-Can, and forms an important part of the reporting of the project. The SR-Can project is a preparatory stage for the SR-Site assessment, and the report from that project will be used in support of SKB's application to build a final repository. The overall objective of the FEP analysis and processing included development of a database of features, events and processes, an SKB FEP database, in a format that facilitates both a systematic analysis of FEPs and documentation of that FEP analysis, as well as facilitating revisions and updates to be made in connection with new safety assessments. The overall objective also extended to the development of procedures for such a systematic FEP analysis as well as the application of those procedures in order to establish an SR-Can FEP catalogue within the framework of the SKB FEP database. The work started by implementing the content of the SR 97 Process Report into a database format suitable for import and processing of FEP information from other sources. The SR 97 version of the database was systematically audited against the NEA database with Project FEPs, version 1.2. In addition, an earlier audit of the SR 97 process report against the interaction matrices developed for a deep repository of the KBS-3 type was revisited and updated. Relevant FEPs identified through the audit process were sorted into three main categories i) FEPs related to the initial states of the repository system, ii) FEPs related to internal processes of the repository system, and iii) FEPs related to external impacts on the repository system. This resulted in additions to the SR 97 list of processes and to the lists of initial state FEPs and external factors to be addressed in further processing. The further processing of the initial state FEPs revealed that those FEPs that are not covered by the

  5. Vacancy induced magnetism in SrTiO3

    International Nuclear Information System (INIS)

    Zhang Yongjia; Hu Jifan; Cao Ensi; Sun Li; Qin Hongwei

    2012-01-01

    Vacancy-induced magnetism in perovskite SrTiO 3 is investigated by ab initio calculations and magnetic measurements. The calculations of the generalized gradient approximation (GGA), the local density approximation (LDA) and the local density approximation with on-site effect U (LDA+U) methods show that stoichiometric SrTiO 3 is nonmagnetic. The GGA calculated results indicate that Ti or O vacancy could induce magnetism rather than Sr vacancy. The LDA and LDA+U calculations show that the Ti vacancy could induce magnetism, while Sr and O vacancies couldn't. The experimental results confirm that SrTiO 3 nanocrystalline powders exhibit room-temperature ferromagnetism (FM) and the magnetic moment results from cation vacancies. - Highlights: ► The possible ferromagnetism (FM) in perovskite SrTiO 3 is investigated. ► The vacancy could induce the magnetism in perovskite materials. ► Theoretical and experimental results indicated that cation vacancy could induce the FM.

  6. Cs-137 and Sr-90 level in diary products

    International Nuclear Information System (INIS)

    Petukhov, V.L.; Dukhanov, Y.A.; Sevryuk, I.Z.; Patrashkov, S.A.; Korotkevich, O.S.; Gorb, T.S.; Petukhov, I.V.

    2003-01-01

    About 70% of radioactive substances fell on the territory of the Byelorussian Republic after the Chernobyl Atom Power Station Disaster. Cs-137 and Sr-90 accumulation dynamics was studied in milk of the cows from the highest polluted Braginsky area. 408 milk samples of Black and White cows were investigated. In 1995 average Cs-137 and Sr-90 levels were 61.00 and 3.73 Bk/dm 3 respectively. Cs-137 and Sr-90 levels exceeded Byelorussian Republic upper limits RDU - 96 in 10 and 50% of milk samples respectively. After 5 years (by 2000) Cs-137 and Sr-90 levels had become almost 3 and 2 times less (21.70 Bk/dm 3 and 1.72 Bk/dm 3 respectively). Cs-137 and Sr-90 levels exceeded RDU - 96 in 1.5 and 5.5% of milk samples respectively. In the same periods Cs-137 and Sr-90 levels were 7 and 2 times higher than the similar indexes in the relatively clean Novosibirsk area. Thus, radioactive element levels in milk of Black and White cows of the Byelorussian Republic decreased significantly for the past years. (authors)

  7. Sr-ISOTOPE RATIOS OF A SOIL PROFILE (BADLANDS NEAR RADICOFANI (SOUTHERN TUSCANY

    Directory of Open Access Journals (Sweden)

    Francesca Castorina

    2010-12-01

    Full Text Available The Sr/Ca ratios and Sr-isotope ratios of bulk samples and acetate extracts from a soil profile developed on Pliocene marine clays near Radicofani, in southern Tuscany, were determined. The uniform Sr/Ca ratios in the soil indicated a uniform distribution of the two elements throughout the profile. In contrast, the lower Sr/Ca ratios of acetate extracts from the upper horizons of the soil suggest preferential removal of Sr relative to Ca, perhaps by the plants. These latter seem to accumulate more Sr than Ca during their lifetime. The δ87Sr of acetate extracts suggests that bulk Sr is provided by the calcite of the Mesozoic-Cenozoic sedimentary formations of southern Tuscany. A minor source of Sr, although subordinate, is represented by clastic albite. A grass sample growing on the soil contained the Sr uptaken from both sources.

  8. Rb-Sr, 87Sr/86Sr isotope system as an index of provenance of continental dusts in the open Atlantic ocean

    International Nuclear Information System (INIS)

    Biscaye, P.E.; Chesselet, Roger; Prospero, J.M.

    1974-01-01

    The Rb-Sr, Sr-isotope system technique was applied to samples of water-insoluble atmospheric dust to test its utility in answering two questions: 1) the continental provenance of the dust, and 2) the relative importance of eolian versus other contributions to deep-sea sediments. Samples of atmospheric dust were taken on Whatman filters during two Atlantic cruises: a north-south section from May to October 1971 (Dakar-Walvis Bay-Azores) and an east-west section from September to October 1972 (Barbados-Dakar). In addition several other filter samples from the Equatorial Atlantic and mesh samples from Barbados were analyzed. The overall pattern of dust concentrations is consistent with the well-known strong Saharan plume at 10-15 deg N latitude and extends westward to the Caribbean with average concentrations in excess of 10 μg/m 3 . The north-south track was relatively near the African coast but permitted some definition of the decrease of dust concentrations north (to about 1 μg/m 3 ) and south (to 3 ) of the main plume. From the 87 Sr/ 86 Sr ratios we distinguish the dusts from the Saharan and a second plume, probably from the Kalahari Desert of southwestern Africa. The ratios of dusts in the Saharan plume are indistinguishable from deep-sea sediments in this latitude band. Adding Rb/Sr to the Sr-isotope ratios in an isochronous plot, however, permits distinction between the dusts and deep-sea sediments east of the Mid-Atlantic Ridge, and from the sediments underlying the Saharan plume but west of the Ridge. The authors conclude that, west of the Ridge, the colian dust contribution to the sediments is strongly diluted by non-eolian sediment sources, confirming with an independant provenance characteristic conclusions derived from sediment mineralogical data [fr

  9. Rb-Sr age determinations and Sr isotope systematics in rocks and minerals of the Regensburger Wald

    International Nuclear Information System (INIS)

    Koehler, H.; Mueller-Sohnius, D.

    1976-01-01

    The results of the Rb/Sr isotope age determinations show: the 'granule gneiss' exhibit materially changed anatexites, the 'granule gneiss formation' of the Regensburger Wald is a varistic occurence. (HK) [de

  10. Transport phenomena in SrVO3/SrTiO3 superlattices

    Science.gov (United States)

    Gu, Man; Wolf, Stuart A.; Lu, Jiwei

    2018-03-01

    Epitaxial [(SrVO3)7/(SrTiO3)4] r (SVO/STO) superlattices were grown on (0 0 1)-oriented LSAT substrates using a pulsed electron-beam deposition technique. The transport properties of the superlattices were investigated by varying the number of repetitions of the SVO/STO bilayers r (1  ⩽  r  ⩽  9). A single SVO/STO bilayer (r  =  1) was semiconducting, whereas an increase in the number of repetitions r resulted in metallic behavior in the superlattices with r  ⩾  3. The transport phenomena in the SVO/STO superlattices can be regarded as conduction through parallel-coupled SVO layers, the SVO layer embedded in the superlattices showed a great enhancement in the conductivity compared with the single SVO layer. This work provides further evidence of electronic phase separation in the SVO ultrathin layer that has been recently discovered, the SVO ultrathin layer is considered as a 2D Mott insulator with metallic and insulating phases coexisting, the coupling between SVO layers embedded in the SVO/STO superlattices creates more conduction pathways with increasing number of repetitions r, resulting in a crossover from insulating to metallic behavior.

  11. Shape coexistence in neutron-rich Sr isotopes : Coulomb excitation of $^{96}$Sr

    CERN Document Server

    Clement, E; Siem, S; Czosnyka, T

    2007-01-01

    The nuclei in the mass region A $\\cong$ 100 around Sr and Zr show a dramatic change of the nuclear ground-state shape from near spherical for N $\\leq$ 58 to strongly deformed for N $\\geq$ 60. Theoretical calculations predict the coexistence of slightly oblate and strongly prolate deformed configurations in the transitional region. However, excited rotational structures based on the highly deformed configuration, which becomes the ground state at N = 60, are not firmly established in the lighter isotopes, and the earlier interpretation of a very abrupt change of shape has been challenged by recent experimental results in favor of a rather gradual change. We propose to study the electromagnetic properties of the neutron-rich nucleus $_{38}^{96}$Sr$_{58}$ by low-energy Coulomb excitation using the REX-ISOLDE facility and the MINIBALL detector array. Both transitional and diagonal matrix elements will be extracted, resulting in a complete description of the transition strengths and quadrupole moments of the low-l...

  12. Fast and sensitive determination of Sr-90 and SR-89 activity in milk by ion-chromatography and liquid scintillation

    International Nuclear Information System (INIS)

    Figueiredo, V.; Herrmann, A.

    1992-01-01

    A method for fast and exact determination of both strontium isotopes in milk and other foodstuffs, combination high performance ion chromatographic separation with by liquid scintillation counting, which enables the desired results to be obtained with very satisfactory precision and reproducibility within 24 hours, has been developed. The lowest detectable activity lies by 3 Bq/liter for Sr-90 and 1 Bq/liter for Sr-89 which is satisfactory for assessing a situation in a time crisis. (author)

  13. Selective deintercalation of apex over face-shared oxide ions in the topotactic reduction of Sr7Mn4O15 to Sr7Mn4O12.

    Science.gov (United States)

    Hayward, M A

    2004-01-21

    Sodium hydride selectively deintercalates the apex rather than face-shared oxide ions within the structure of Sr(7)Mn(4)O(15) leading to the formation of the structurally related reduced phase Sr(7)Mn(4)O(12).

  14. Characterization of magnetic properties of Sr2CuWO6 and Sr2CuMoO6

    Science.gov (United States)

    Vasala, Sami; Saadaoui, Hassan; Morenzoni, Elvezio; Chmaissem, Omar; Chan, Ting-Shan; Chen, Jin-Ming; Hsu, Ying-Ya; Yamauchi, Hisao; Karppinen, Maarit

    2014-04-01

    In this work we examine the low-temperature magnetic properties of the two double-perovskite compounds Sr2CuWO6 and Sr2CuMoO6 using magnetic susceptibility, muon spin rotation and relaxation, and neutron powder diffraction measurements. Additionally, the most relevant spin exchange interaction constants are derived from ab initio electronic structure calculations, aided by x-ray absorption spectroscopy. The compounds exhibit quasi-two-dimensional magnetic properties, with broad maxima at Tmax = 83 and 95 K for Sr2CuWO6 and Sr2CuMoO6, respectively. However, three-dimensional long-range order takes place below TN = 24(1) and 28(2) K for Sr2CuWO6 and Sr2CuMoO6, respectively. Our results show that the low-dimensional magnetic correlations are mainly due to the significant next-nearest-neighbor interactions in the ab plane of the double-perovskite structure, whereas three-dimensional long-range magnetic order is caused by weaker next-nearest-neighbor interactions along the c axis. Next-nearest-neighbor interactions are also slightly frustrated by weaker nearest-neighbor interactions within the ab plane. Based on these results we predict the low-temperature magnetic structure in these compounds to be type-II antiferromagnetic order of the double-perovskite lattice.

  15. Rapid Simultaneous Determination of 89Sr and 90Sr in Milk: A Procedure Using Cerenkov and Scintillation Counting

    International Nuclear Information System (INIS)

    2013-01-01

    Since 2004, the IAEA programme related to the terrestrial environment has included activities aimed at developing and testing a set of procedures for the determination of radionuclides in environmental samples. Both 89Sr and 90Sr are fission products that can be, and have been, released to the environment during nuclear explosions and nuclear reactor accidents. Since strontium uptake from milk is an important pathway for incorporation of radioactive strontium into the human body, the rapid and accurate analysis of radioactive strontium isotopes in milk is of crucial importance in emergency situations in order to protect the public from radiation hazards. This report describes a new approach for the rapid determination of 89 Sr and 90Sr in milk using Cerenkov and scintillation counting methods that was tested and validated by the analysis of four spiked milk samples in terms of repeatability, reproducibility and trueness (relative bias) in accordance with ISO guidelines. The report also describes the calculation of the uncertainty budget. This research was proposed in 2007 at the Asia-Pacific regional meeting of the IAEA Analytical Laboratories for the Measurement of Environmental Radioactivity (ALMERA) network. Several ALMERA network laboratories participated in the validation procedure by performing reproducibility tests. The resulting recommended procedure is designed to be of general use to a wide range of laboratories, including those in the ALMERA network. It is expected that this rapid method for determining 89 Sr and 90 Sr in milk will be useful in emergency conditions and for routine environmental monitoring of elevated levels of radioactivity

  16. Comparative description of magnetic interactions in Sr2CuTeO6 and Sr2CuWO6

    Science.gov (United States)

    Xu, Yuanhui; Liu, Shanshan; Qu, Nianrui; Cui, Yanli; Gao, Qiangqiang; Chen, Rongna; Wang, Jing; Gao, Faming; Hao, Xianfeng

    2017-03-01

    In this work, we comparatively explored the electronic structure and the low-dimensional magnetic interactions of double-perovskite compounds Sr2CuTeO6 and Sr2CuWO6 through first-principles calculations. The electronic structure calculations indicate that the Cu2+ (3d 9) site is the only magnetic active one, whereas Te6+ and W6+ remain in nonmagnetic states with d 10 and d 0 electronic configurations, respectively. The magnetic exchange interactions have been evaluated on the basis of the classical Heisenberg model. Both Sr2CuTeO6 and Sr2CuWO6 should be strong frustrated 2D magnetism, in excellent agreement with the experimental observations. Nevertheless, the nearest-neighbor antiferromagnetic interaction J 1 plays a determined role in constructing the Néel antiferromagnetic ordering within the square Cu2+ framework of Sr2CuTeO6. While, the next-nearest-neighbor antiferromagnetic interaction J 2 transcends the nearest-neighbor interaction J 1, establishes the collinear antiferromagnetic ordering in Sr2CuWO6. The discrimination has been explored and analyzed in detail using density of states, charge density as well as spin density analysis.

  17. 87Sr/86Sr sourcing of ponderosa pine used in Anasazi great house construction at Chaco Canyon, New Mexico

    Science.gov (United States)

    Reynolds, Amanda C.; Betancourt, Julio L.; Quade, Jay; Patchett, P. Jonathan; Dean, Jeffery S.; Stein, John

    2005-01-01

    Previous analysis of 87Sr/86Sr ratios shows that 10th through 12th century Chaco Canyon was provisioned with plant materials that came from more than 75 km away. This includes (1) corn (Zea mays) grown on the eastern flanks of the Chuska Mountains and floodplain of the San Juan River to the west and north, and (2) spruce (Picea sp.) and fir (Abies sp.) beams from the crest of the Chuska and San Mateo Mountains to the west and south. Here, we extend 87Sr/86Sr analysis to ponderosa pine (Pinus ponderosa) prevalent in the architectural timber at three of the Chacoan great houses (Pueblo Bonito, Chetro Ketl, Pueblo del Arroyo). Like the architectural spruce and fir, much of the ponderosa matches the 87Sr/86Sr ratios of living trees in the Chuska Mountains. Many of the architectural ponderosa, however, have similar ratios to living trees in the La Plata and San Juan Mountains to the north and Lobo Mesa/Hosta Butte to the south. There are no systematic patterns in spruce/fir or ponderosa provenance by great house or time, suggesting the use of stockpiles from a few preferred sources. The multiple and distant sources for food and timber, now based on hundreds of isotopic values from modern and archeological samples, confirm conventional wisdom about the geographic scope of the larger Chacoan system. The complexity of this procurement warns against simple generalizations based on just one species, a single class of botanical artifact, or a few isotopic values.

  18. Production of long lived parent radionuclides for generators: 68Ge, 82Sr, 90Sr and 188W

    International Nuclear Information System (INIS)

    2010-01-01

    Radionuclide generators represent convenient in-house radionuclide production systems that allow daughter species to be obtained even in the absence of on-site reactor or accelerator facilities. The resurgence in interest in the use of radionuclide generator systems is due to the development of new targeting strategies using specific carrier molecules for the development of both diagnostic and therapeutic radiopharmaceuticals. This publication provides information on the production and processing of four important long lived parent radionuclides, 68 Ge, 82 Sr, 90 Sr and 188 W, used for the preparation of generators for nuclear medicine applications such as positron emission tomography (PET) or therapy. Germanium-68 is used for the 68 Ge/ 68 Ga generator system, which provides no-carrier-added 68 Ga for use in PET imaging. Gallium-68 labelled tumour specific peptides are now in routine use for PET imaging of certain types of cancer. Strontium-82 is used as the parent for the production of 82 Sr/ 82 Rb generator systems. Rubidium-82 is an important PET marker for myocardial perfusion studies. This report describes the processing and purification of 90 Sr from fission products, which can provide 90 Sr suitable for fabrication of the 90 Sr/ 90 Y generator. Yttrium-90 is widely used for a variety of important therapeutic applications. Reactor production and subsequent processing of 188 W provides this important parent species for fabrication of the 188 W/ 188 Re generator system to obtain 188Re perrhenate for incorporation into various therapeutic agent

  19. Tube extrusion of AZ31 alloy with Sr additions

    Energy Technology Data Exchange (ETDEWEB)

    Sadeghi, Alireza, E-mail: Alireza.Sadeghi@mail.mcgill.ca [McGill University, Department of Mining and Materials Science, Montreal, Quebec (Canada); Hoseini, Majid; Pekguleryuz, Mihriban [McGill University, Department of Mining and Materials Science, Montreal, Quebec (Canada)

    2012-05-15

    Highlights: Black-Right-Pointing-Pointer Bending and unbending of material flow during extrusion tilts the basal pole from the center of the pole figure. Black-Right-Pointing-Pointer Circumferential movement of material inside the welding zone forms two extra texture components. Black-Right-Pointing-Pointer Addition of Sr removes Al from {alpha}-Mg as a result grains could deform more easily in the circumferential directions. Black-Right-Pointing-Pointer By increasing level of Sr, maximum intensity of the ODFs decreases while the extra texture components strengthen. - Abstract: Three Mg alloys (AZ31, and AZ31 + 0.4 and 0.8 wt%Sr) were successfully hot extruded into tubes at 400 Degree-Sign C through a porthole die. Strontium (Sr) additions to AZ31 alloy reduced twining and the dynamically recrystallized grain size. However, Sr also increased the surface cracking tendency during extrusion. It was noted that the complex deformation path in the porthole die distributes the Sr-rich precipitates homogeneously across the microstructure and stringer formation is effectively avoided. The material flow in the die resembles that seen in multiple equal channel angular pressing (ECAP) routes and similar and significant effects on the final texture are observed. The material flow curvatures in the extrusion direction rotate the basal poles 25 Degree-Sign from the radial direction. Two other texture components ({delta}{sub 1}, {delta}{sub 2}) are also formed in the welding zone by the circumferential flow of material. The maximum intensity of the orientation distribution function (ODF) is reduced with increasing level of Sr. Noteworthy, the maximum intensity in AZ31 + 0.8Sr occurs at the {delta}{sub 1} component while for AZ31 and AZ31 + 0.4Sr, the maximum intensity is located at the basal components. With Sr, alloying, Al is depleted from Mg solid solution and grains deform more easily in the circumferential direction. As a result, selective workhardening

  20. Phase study in Sr-Th-P-O system: Structural and thermal investigations of quaternary compounds

    International Nuclear Information System (INIS)

    Keskar, Meera; Phatak, Rohan; Sali, S.K.; Krishnan, K.; Dahale, N.D.; Kulkarni, N.K.; Kannan, S.

    2011-01-01

    The sub-solidus phase relations in Sr-Th-P-O quaternary system were determined at 1223 K in air. To confirm the formation and stability of reported phases, ternary and quaternary compounds in Sr-Th-O, Sr-P-O, Th-P-O and Sr-Th-P-O systems were synthesized by solid state reactions of SrCO 3 , ThO 2 and NH 4 H 2 PO 4 in desired molar proportions at 1223 K. A pseudo-ternary phase diagram of SrO-ThO 2 -P 2 O 5 system was drawn on the basis of the phase analysis of various phase mixtures and phase fields were established by powder X-ray diffraction. In the phase diagram, three quaternary compounds SrTh(PO 4 ) 2 , SrTh 4 (PO 4 ) 6 and Sr 7 Th(PO 4 ) 6 were identified. When heated in air at 1673 K, these compounds decompose to ThO 2 . Structures of SrTh(PO 4 ) 2 , SrTh 4 (PO 4 ) 6 and Sr 7 Th(PO 4 ) 6 were derived from X-ray powder data using the Rietveld refinement method. Thermal expansion behaviors of SrTh(PO 4 ) 2 , SrTh 4 (PO 4 ) 6 and Sr 7 Th(PO 4 ) 6 were investigated using high-temperature X-ray diffraction in the temperature range of 298-1273 K.

  1. Effect of Flowing Water on Sr Sorption Changes of Hydrous Sodium Titanate

    Directory of Open Access Journals (Sweden)

    Youko Takahatake

    2017-12-01

    Full Text Available Radioactive contaminated water has been generated at the Fukushima Daiichi Nuclear Power station (F1NPS. Hydrous sodium titanate (SrTreat® is able to remove radioactive Strontium (Sr from this water. Knowing the amount of radioactive nuclides in the used as-received SrTreat® is important for effective disposal and deposition of the F1NPS waste. This study investigated changes in the ability of SrTreat® to sorb Sr, and to understand the causes of changes in the sorbing. An investigation of the Sr sorption ability of SrTreat® is important for calculating the initial radioactive inventory of used SrTreat®. This study carries out Sr sorption studies with acid-base titrations and X-ray photoelectron spectroscopy (XPS to characterize the properties. After exposure to simulated treated water for 99 h, the surface structure of the SrTreat® was changed, and the percentage of sorbed Sr and the buffer capacity for protons decreased. When the amount of radioactive nuclides contained in the used SrTreat® is calculated from the sorption data of the as-received SrTreat®, the radioactive Sr content will be overestimated with a concomitant increase in the deposition and disposal costs of the used SrTreat®.

  2. Non-Chondritic Stable Strontium (δ88Sr vs. δ84Sr) in the Earth, the Moon and Some Differentiated Asteroids

    Science.gov (United States)

    Charlier, B. L.; Parkinson, I. J.; Burton, K. W.; Grady, M. M.

    2014-12-01

    The determination of isotopic anomalies in early solar system materials provides important constraints on the nucleosynthetic origin and isotopic fractionation of elements during nebular condensation and subsequent processing in the protoplanetary disk. Several recent studies involving high-precision Sr isotope measurements have pointed towards the possibility of small excesses in the minor p-process isotope 84Sr in chondritic meteorites. However, these data remain equivocal because of the reliance on internal normalization to a fixed value of 0.1194 for the 86Sr/88Sr in order to correct for instrumental mass fractionation. On the basis of such data alone, it is not possible to determine with certainty which isotopes have anomalous abundances. Here, we present new high-precision 84Sr-87Sr double spike data that return the true isotopic composition for all the Sr isotope ratios, free from any assumptions about normalization values. Our new data demonstrate that the Earth, the Moon, eucrites and diogenites plus several angrites lie on a single mass-dependent fractionation trend in three isotope space (δ88Sr vs δ84Sr). In contrast, bulk CI, CM and CV3 carbonaceous chondrites have highly variable δ88Sr but lie on a separate mass-dependent fractionation line of identical slope which is offset towards excess 84Sr by ca. 100 ppm. Several aliquots of the angrite Sahara 99555 yield high δ84Sr values, but with 'normal' δ88Sr similar to other angrites. Stable Sr variations in chondritic meteorites most probably reflect primary Sr isotope nucleosynthetic heterogeneity in the early solar system, whilst those for Sahara 99555 indicate later addition of distinct chondritic material. Our new Sr double-spike data clearly demonstrate fundamental differences between materials forming the asteroids and terrestrial planets versus chondritic materials (in particular CI meteorites) thought to be the closest representative of solar photosphere composition.

  3. 90Sr and 89Sr in seawater off Japan as a consequence of the Fukushima Dai-ichi nuclear accident

    Directory of Open Access Journals (Sweden)

    N. Casacuberta

    2013-06-01

    Full Text Available The impact of the earthquake and tsunami on the east coast of Japan on 11 March 2011 caused a loss of power at the Fukushima Dai-ichi nuclear power plant (NPP that resulted in one of the most important releases of artificial radioactivity into the environment. Although several works were devoted to evaluating the atmospheric dispersion of radionuclides, the impact of the discharges to the ocean has been less investigated. Here we evaluate the distribution of Fukushima-derived 90Sr (n = 57 and 89Sr (n = 19 throughout waters 30–600 km offshore in June 2011. Concentrations of 90Sr and 89Sr in both surface waters and shallow profiles ranged from 0.8 ± 0.2 to 85 ± 3 Bq m−3 and from 19 ± 6 to 265 ± 74 Bq m−3, respectively. Because of its short half-life, all measured 89Sr was due to the accident, while the 90Sr concentrations can be compared to the background levels in the Pacific Ocean of about 1.2 Bq m−3. Fukushima-derived radiostrontium was mainly detected north of Kuroshio Current, as this was acting as a southern boundary for transport. The highest activities were associated with near-shore eddies, and larger inventories were found in the closest stations to Fukushima NPP. The data evidence a major influence of direct liquid discharges of radiostrontium compared to the atmospheric deposition. Existing 137Cs data reported from the same samples allowed us to establish a 90Sr / 137Cs ratio of 0.0256 ± 0.0006 in seawater off Fukushima, being significantly different than that of the global atmospheric fallout (i.e., 0.63 and may be used in future studies to track waters coming from the east coast of Japan. Liquid discharges of 90Sr to the ocean were estimated, resulting in an inventory of 53 ± 1 TBq of 90Sr in the inshore study area in June 2011 and total releases of 90Sr ranging from 90 to 900 TBq, depending upon the reported estimates of 137Cs releases that are considered.

  4. Sr36- and Sr5-Mediated Resistance Response to Puccinia graminis f. sp. tritici Is Associated with Callose Deposition in Wheat Guard Cells.

    Science.gov (United States)

    Wang, X; McCallum, B D; Fetch, T; Bakkeren, G; Saville, B J

    2015-06-01

    Race-specific resistance of wheat to Puccinia graminis f. sp. tritici is primarily posthaustorial and often involves the induction of a hypersensitive response (HR). The aim of this study was to investigate host defense responses induced in interactions between P. graminis f. sp. tritici races and wheat lines carrying different race-specific stem rust resistance (Sr) genes. In incompatible interactions between wheat lines carrying Sr36 in three genetic backgrounds (LMPG, Prelude, or W2691) and avirulent P. graminis f. sp. tritici races MCCFC or RCCDM, callose accumulated within 24 h in wheat guard cells contacted by a P. graminis f. sp. tritici appressorium, and P. graminis f. sp. tritici ingress was inhibited following appressorium formation. Accordingly, the expression of transcripts encoding a callose synthase increased in the incompatible interaction between LMPG-Sr36 and avirulent P. graminis f. sp. tritici race MCCFC. Furthermore, the inhibition of callose synthesis through the infiltration of 2-deoxy-D-glucose (DDG) increased the ability of P. graminis f. sp. tritici race MCCFC to infect LMPG-Sr36. A similar induction of callose deposition in wheat guard cells was also observed within 24 h after inoculation (hai) with avirulent P. graminis f. sp. tritici race HKCJC on LMPG-Sr5 plants. In contrast, this defense response was not induced in incompatible interactions involving Sr6, Sr24, or Sr30. Instead, the induction of an HR and cellular lignification were noted. The manifestation of the HR and cellular lignification was induced earlier (24 hai) and was more extensive in the resistance response mediated by Sr6 compared with those mediated by Sr24 or Sr30. These results indicate that the resistance mediated by Sr36 is similar to that mediated by Sr5 but different from those triggered by Sr6, Sr24, or Sr30. Resistance responses mediated by Sr5 and Sr36 are prehaustorial, and are a result of very rapid recognition of molecules derived from avirulent isolates of

  5. SR 97. Processes in the repository evolution. Background report to SR 97

    International Nuclear Information System (INIS)

    Hedin, A.

    1999-11-01

    This report describes, in a comprehensive and coherent fashion, all identified internal processes of importance for the post-closure evolution and safety of a KBS-3 repository for spent nuclear fuel. The report has been written to be used in the SR 97 project, which has limited the time available for its preparation. Differences in the level of detail in descriptions of different processes do not always reflect differences in the significance of the processes. Discussions of different types of uncertainties could in many cases be broadened and deepened, and the stylistic quality could sometimes be improved. Like other background material for the safety assessments, the process report is also expected to require revision as site-specific conditions are progressively clarified. Today's version of the process report is therefore the first version of a report that will be revised prior to every safety report. The intention is to perform the first revision of the report after scrutiny of SR 97. The report describes the internal processes which over time lead to changes in a KBS-3 repository for spent nuclear fuel. The context of the material in the report is described in SR 97 Main Report and briefly entails the following: The repository has been divided into four subsystems: fuel/cavity, cast iron insert/copper canister, buffer/backfill and geosphere. A number of processes of importance for the post-closure evolution of the repository have been identified within each subsystem. This has been done with the aid of material in the so-called interaction matrices previously developed by SKB. The processes have been divided into the categories thermal, hydraulic, mechanical and chemical. Furthermore, there are processes related to radiation and radionuclide transport. The identified processes are documented in this report. Each subsystem has its own chapter, and each chapter is divided into radiation related, thermal, hydraulic, mechanical and chemical processes as well as

  6. SR 97. Processes in the repository evolution. Background report to SR 97

    Energy Technology Data Exchange (ETDEWEB)

    Hedin, A. [ed.

    1999-11-01

    This report describes, in a comprehensive and coherent fashion, all identified internal processes of importance for the post-closure evolution and safety of a KBS-3 repository for spent nuclear fuel. The report has been written to be used in the SR 97 project, which has limited the time available for its preparation. Differences in the level of detail in descriptions of different processes do not always reflect differences in the significance of the processes. Discussions of different types of uncertainties could in many cases be broadened and deepened, and the stylistic quality could sometimes be improved. Like other background material for the safety assessments, the process report is also expected to require revision as site-specific conditions are progressively clarified. Today's version of the process report is therefore the firstversion of a report that will be revised prior to every safety report. The intention is to perform the first revision of the report after scrutiny of SR 97. The report describes the internal processes which over time lead to changes in a KBS-3 repository for spent nuclear fuel. The context of the material in the report is described in SR 97 Main Report and briefly entails the following: The repository has been divided into four subsystems: fuel/cavity, cast iron insert/copper canister, buffer/backfill and geosphere. A number of processes of importance for the post-closure evolution of the repository have been identified within each subsystem. This has been done with the aid of material in the so-called interaction matrices previously developed by SKB. The processes have been divided into the categories thermal, hydraulic, mechanical and chemical. Furthermore, there are processes related to radiation and radionuclide transport. The identified processes are documented in this report. Each subsystem has its own chapter, and each chapter is divided into radiation related, thermal, hydraulic, mechanical and chemical processes as well

  7. SR 97. Processes in the repository evolution. Background report to SR 97

    International Nuclear Information System (INIS)

    Hedin, A.

    1999-11-01

    This report describes, in a comprehensive and coherent fashion, all identified internal processes of importance for the post-closure evolution and safety of a KBS-3 repository for spent nuclear fuel. The report has been written to be used in the SR 97 project, which has limited the time available for its preparation. Differences in the level of detail in descriptions of different processes do not always reflect differences in the significance of the processes. Discussions of different types of uncertainties could in many cases be broadened and deepened, and the stylistic quality could sometimes be improved. Like other background material for the safety assessments, the process report is also expected to require revision as site-specific conditions are progressively clarified. Today's version of the process report is therefore the first version of a report that will be revised prior to every safety report. The intention is to perform the first revision of the report after scrutiny of SR 97. The report describes the internal processes which over time lead to changes in a KBS-3 repository for spent nuclear fuel. The context of the material in the report is described in SR 97 Main Report and briefly entails the following: The repository has been divided into four subsystems: fuel/cavity, cast iron insert/copper canister, buffer/backfill and geosphere. A number of processes of importance for the post-closure evolution of the repository have been identified within each subsystem. This has been done with the aid of material in the so-called interaction matrices previously developed by SKB. The processes have been divided into the categories thermal, hydraulic, mechanical and chemical. Furthermore, there are processes related to radiation and radionuclide transport. The identified processes are documented in this report. Each subsystem has its own chapter, and each chapter is divided into radiation related, thermal, hydraulic, mechanical and chemical processes as well as

  8. Development of PCR markers for the selection of wheat stem rust resistance genes Sr24 and Sr26 in diverse wheat germplasm.

    Science.gov (United States)

    Mago, R; Bariana, H S; Dundas, I S; Spielmeyer, W; Lawrence, G J; Pryor, A J; Ellis, J G

    2005-08-01

    The use of major resistance genes is the most cost-effective strategy for preventing stem rust epidemics in Australian wheat crops. The long-term success of this strategy is dependent on combining resistance genes that are effective against all predominant races of the pathogen, a task greatly assisted by the use of molecular markers linked to individual resistance genes. The wheat stem rust resistance genes Sr24 and Sr26 (derived from Agropyron elongatum) and SrR and Sr31 (derived from rye) are available in wheat as segments of alien chromosome translocated to wheat chromosomes. Each of these genes provides resistance to all races of wheat stem rust currently found in Australia . We have developed robust PCR markers for Sr24 and Sr26 (this study) and SrR and Sr31 (previously reported) that are applicable across a wide selection of Australian wheat germplasm. Wheat lines have recently become available in which the size of the alien segments containing Sr26, SrR and Sr31 has been reduced. Newly developed PCR-markers can be used to identify the presence of the shorter alien segment in all cases. Assuming that these genes have different gene-for-gene specificities and that the wheat industry will discourage the use of varieties carrying single genes only, the newly developed PCR markers will facilitate the incorporation of two or more of the genes Sr24, Sr26, SrR and Sr31 into wheat lines and have the potential to provide durable control to stem rust in Australia and elsewhere.

  9. Preparation and characterization of Sr-Ti-hardystonite (Sr-Ti-HT nanocomposite for bone repair application

    Directory of Open Access Journals (Sweden)

    Hossein Mohammadi

    2015-07-01

    Full Text Available Objective(s: Hardystonite (HT is Zn-modified silicate bioceramics with promising results for bone tissue regeneration. However, HT possesses no obvious apatite formation. Thus, in this study we incorporated Sr and Ti into HT to prepare Sr-Ti-hardystonite (Sr-Ti-HT nanocomposite and evaluated its in vitro bioactivity with the purpose of developing a more bioactive bone substitute material. Materials and methods:The HT and Sr-Ti-HT were prepared by mechanical milling and subsequent heat treatment. Calcium oxide (CaO, zinc oxide (ZnO and silicon dioxide (SiO2 (all from Merck were mixed with molar ratio of 2:1:2. The mixture of powders mixture was then milled in a planetary ball mill for 20 h. In the milling run, the ball-to-powder weight ratio was 10:1 and the rotational speed was 200 rpm. After synthesis of HT, 3% nanotitanium dioxide (TiO2, Degussa and 3% strontium carbonate (SrCO3, Merck were added to HT and then the mixture was ball milled and calcined at 1150°C for 6 h. Simultaneous thermal analysis (STA, X-ray diffraction (XRD, Transmission electron microscopy (TEM and Fourier transform infra-red spectroscopy (FT-IR performed to characterize the powders. Results:XRD and FT-IR confirmed the crystal phase and silicate structure of HT and TEM images demonstrated the nanostructure of powders. Further, Sr-Ti-HT induced apatite formation and showed a higher human mesenchymal stem cell (hMSCs adhesion and proliferation compared to HT. Conclusion:Our study revealed that Sr-Ti-HT with a nanostructured crystal structure of 50 nm, can be prepared by mechanical activation to use as biomaterials for orthopedic applications.

  10. Influence of Bi-Sr and Ca-Sr interactions on the Si particle characteristics in 319 alloy

    International Nuclear Information System (INIS)

    El-Hadad, S.; Samuel, A.M.; Samuel, F.H.; Doty, H.W.; Valtierra, S.

    2002-01-01

    The effects of bismuth and calcium additions on the Si particle characteristics in Sr-modified 319 alloys (modified with 80 ppm Sr), with and without 0.4 wt% Mg addition, were studied using thermal analysis, optical microscopy, image and SEM/EDX analyses. Bismuth additions were made in the range 50 to 9000 ppm, and calcium additions in the range 50 to 200 ppm. The effects of Bi and Ca were monitored through (i) correlation of the eutectic temperature, and (ii) correlation of the microstructural changes with the trace element additions, (iii) evaluation and quantification of the eutectic Si particles, and (iv) identification of the different phases that precipitated as a result of the additions. It was found that the modification effect of Sr continuously diminished with Bi addition up to ∼3000 ppm Bi, following which, further Bi addition led to the modification of the Si particles due to the presence of Bi. In the Ca-containing alloys, it was found that a coarse eutectic Si structure resulted with Ca additions of 50 ppm, due to the formation of Al x (Ca,Sr)Si y compounds. Increased Ca additions (up to 200 ppm) did not alter the Si particle size. The Al x (Ca,Sr)Si y phase particles appeared in rod-like form in the Sr-modified alloys and in plate-like form in the 0.4 wt% Mg-containing alloys. The presence of MgO, Al 2 0 3 , and AlP particles at the center of the plate-like Al x (Ca,Sr)Si y phase appear to act as nucleants for the precipitation of the latter, aiding its growth through an impurity induced twinning mechanism. (author)

  11. Sr ISOTOPES AND ROMAGNA WINES: AN OPPORTUNITY FOR BETTER TRADING?

    Directory of Open Access Journals (Sweden)

    Umberto Masi

    2011-12-01

    Full Text Available The Sr isotopic compositions of 11 wines from Romagna were determined with the aim of providing a new parameter to track the origin of these wines and serving for better trading. The 87Sr values measured ranged narrowly from -0.07 to +0.33 permil, in agreement with the provenance of the parent grapes from an area characterized by substantial uniformity of soil composition. However, so far, it is possible to make a preliminary distinction of the Sangiovese wines from the other wines analyzed because the former contain slightly more radiogenic Sr. This may reflect the different soil geology of vineyards, as the Sangiovese wines are made from grapes mainly growing on flysch soils, while the other wines are from grapes growing on sedimentary and alluvial Pliocene-Quaternary soils. The comparison of the data from Romagna wines with those of other Italian regions shows the potential of the 87Sr to characterize most of these products. However, the data are ambiguous for distinguishing the wines from vinyards growing on similar lithologies, i.e. soils developed on Late Cenozoic sedimentary rocks. The application of Sr isotopes may be a promising tool for setting the fingerprints of wines when combined with other isotopic and chemical parameters.

  12. Quarterly 90Sr deposition at world land sites: Appendix A

    International Nuclear Information System (INIS)

    Toonkel, L.E.

    1981-01-01

    The results of quarterly 90 Sr fallout sampling data at 75 sites beginning in 1976 are presented. Of the 75 sites for which data are reported, the monthly collections at 67 sites are composited and analyzed quarterly starting with the July 1976 samples. Data reported for the first half of 1976 at these sites as well as for the whole year at New York City and through June 1977 at the Australian sites, are quarterly results obtained by summing the monthly data. As of July 1977, the Australian sites have changed over to quarterly collection. The collections are made using either high-walled stainless steel pots with exposed areas of 0.076 square meters or plastic funnels with exposed areas of 0.072 square meters to which are attached ion-exchange columns. A few sites which were established as part of a precipitation chemistry network use plastic pots with an area of 0.064 square meters for collection. As an example of deposition patterns in the Northern Hemisphere, the quarterly 90 Sr data for New York City are shown in graph form. Calculated values of concentrations of 90 Sr in precipitation are given in units of pCi of 90 Sr per liter. The precipitation in centimeters and the 90 Sr deposition in millicuries per square kilometer is given for each quarter where data are available

  13. Determination of 90Sr in the bones of Wildlife using SPE sorbent AnaLig(R) SR01 and the extraction medium TBF

    International Nuclear Information System (INIS)

    Darazova, L.; Dulanska, S.; Matel, L.

    2015-01-01

    9 0Sr was separated from the bones of wild animals from different localities of Slovakia by liquid extraction method with tributyl phosphate (TBF) and the method of molecular recognition with selective sorbent AnaLig (R) Sr01 from IBC Advanced Technologies, Inc. Comparing methodologies by linear regression, the authors found that both methodologies are appropriate for the determination of 90 Sr and provide consistent results. The specific activity of 90 Sr in roe-deer bones were in the range (7.8 to 78.5) Bq · kg -1 , where the highest activity of 90 Sr was determined in the bones of the Trencin region. (authors)

  14. Comparison of the Sr isotopic signatures in brines of the Canadian and Fennoscandian shields

    International Nuclear Information System (INIS)

    Negrel, Philippe; Casanova, Joel

    2005-01-01

    A synthesis of Sr isotope data from shallow and deep groundwaters, and brines from the Fennoscandian and Canadian Shields is presented. A salinity gradient is evident in the water with concentrations varying from approximately 1-75 g L -1 below 1500 m depth in the Fennoscandian Shield and from 10 up to 300 g L -1 below 650 m depth in the Canadian Shield. Strontium isotope ratios were measured to assess the origin of the salinity and evaluate the degree of water-rock interaction in the systems. In both shields, the Sr concentrations are enriched relative to Cl, defining a positive trend parallel to the seawater dilution line and indicative of Sr addition through weathering processes. The depth distribution for Sr concentration increases strongly with increasing depth in both shields although the variation in Sr-isotope composition does not mirror that of Sr concentrations. Strontium-isotope compositions are presented for surface waters, and groundwaters in several sites in the Fennoscandian and Canadian Shields. Numerous mixing lines can be drawn reflecting water-rock interaction. A series of calculated lines links the surface end-members (surface water and shallow groundwater) and the deep brines; these mixing lines define a range of 87 Sr/ 86 Sr ratios for the deep brines in different selected sites. All sites show a specific 87 Sr/ 86 Sr signature and the occurrence of large 87 Sr/ 86 Sr variations is site specific in both shields. In Canadian Shield brines, the Sr isotope ratios clearly highlight large water rock interaction that increases the 87 Sr/ 86 Sr ratio from water that could have been of marine origin. In contrast to the Canadian Shield, groundwater does not occur in closed pockets in the Fennoscandian, and the well-constrained 87 Sr/ 86 Sr signatures in deep brines should correspond to a large, well-mixed and homogeneous water reservoir, whose Sr isotope signature results from water-rock interaction

  15. Experimental evidence shows no fractionation of strontium isotopes ((87)Sr/(86)Sr) among soil, plants, and herbivores: implications for tracking wildlife and forensic science.

    Science.gov (United States)

    Flockhart, D T Tyler; Kyser, T Kurt; Chipley, Don; Miller, Nathan G; Norris, D Ryan

    2015-01-01

    Strontium isotopes ((87)Sr/(86)Sr) can be useful biological markers for a wide range of forensic science applications, including wildlife tracking. However, one of the main advantages of using (87)Sr/(86)Sr values, that there is no fractionation from geological bedrock sources through the food web, also happens to be a critical assumption that has never been tested experimentally. We test this assumption by measuring (87)Sr/(86)Sr values across three trophic levels in a controlled greenhouse experiment. Adult monarch butterflies were raised on obligate larval host milkweed plants that were, in turn, grown on seven different soil types collected across Canada. We found no significant differences between (87)Sr/(86)Sr values in leachable Sr from soil minerals, organic soil, milkweed leaves, and monarch butterfly wings. Our results suggest that strontium isoscapes developed from (87)Sr/(86)Sr values in bedrock or soil may serve as a reliable biological marker in forensic science for a range of taxa and across large geographic areas.

  16. Half-life determination of 88Y and 89Sr

    International Nuclear Information System (INIS)

    Amiot, M.N.; Bouchard, J.; Be, M.M.; Adamo, J.A.

    2005-01-01

    Half-life measurements have been carried out at LNHB for 88 Y using a 4π γ-ionisation chamber and for 89 Sr using a proportional counter. The determined half-life values and associated standard uncertainties are 106.63±0.05 d for 88 Y and 50.65±0.05 d for 89 Sr, being consistent with relevant values reported in literature. Based on the present results and relevant literature values revised recommended half-life values and associated standard uncertainties are proposed, viz. 106.626±0.021 d for 88 Y and 50.57±0.03 d for 89 Sr

  17. Quantum Logic with Composite Pulse Sequences on Sr^+

    Science.gov (United States)

    Shewmon, Ruth; Labaziewicz, Jaroslaw; Ge, Yufei; Wang, Shannon; Chuang, Isaac L.

    2008-03-01

    The optical 5S1/2->4D1/2 transition in Sr^+ is an attractive qubit because it can be addressed by diode lasers, which are relatively inexpensive and easy to operate. We characterize single-qubit rotations as well as a CNOT gate on a Sr^+ ion in a surface electrode Paul trap. To improve these operations, the frequency of the clock laser is stabilized to a high-finesse optical cavity. The resulting linewidth of the laser is approximately 300Hz. Composite pulse sequences, a technique adapted from NMR, have been shown to reduce the effects of systematic errors in a variety of quantum systems. We demonstrate several composite sequences that improve the fidelity of quantum logic operations on Sr^+.

  18. Electron color centers in SrF2-Na crystals

    International Nuclear Information System (INIS)

    Kachan, S.I.; Chornij, Z.P.

    2006-01-01

    A radiation-induced memory effect in SrF 2 -Na crystals is studied. It was shown that optical bleaching of M + A color centers at 80 K in SrF 2 -Na crystals causes the core of an M + A -center to transform into the V + a Me + V + a configuration, in which all three point defects are arranged diagonally in the cube cell. Reirradiation of an optically bleached crystal by X-rays generates F D centers in it. The F D →M + A transformation in SrF 2 -Na crystals occurs at T = 135 K, in contrast to the F A →M + A transformations, which take place at T > 200 K [ru

  19. Data report for the safety assessment SR-Can

    Energy Technology Data Exchange (ETDEWEB)

    Vahlund, Fredrik [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden); Andersson, Johan [JA Streamflow AB, Aelvsjoe (Sweden); Loefgren, Martin [Kemakta Konsult AB, Stockholm (Sweden)

    2006-11-15

    This report is the data report derived within the project SR-Can. The purpose of the data report is to present input data, with uncertainty estimates, for the SR-Can assessment calculations. Data presented in the report have been derived using standardised procedures following a methodology which is presented in the initial part of the report. In this part, a template is presented that has been used when assessing input data in supporting documents as illustrated in subsequent chapters of the data report. By using the template, decisions by the SR-Can team are separated from expert input. This increases the traceability of assessment decisions. The data report supplies assessment data for all parts of the repository system, the fuel, the canister, the buffer and backfill and the geosphere. For the geosphere, many of the data are based on information obtained during the site investigation programme.

  20. Data report for the safety assessment SR-Can

    International Nuclear Information System (INIS)

    Vahlund, Fredrik; Andersson, Johan; Loefgren, Martin

    2006-11-01

    This report is the data report derived within the project SR-Can. The purpose of the data report is to present input data, with uncertainty estimates, for the SR-Can assessment calculations. Data presented in the report have been derived using standardised procedures following a methodology which is presented in the initial part of the report. In this part, a template is presented that has been used when assessing input data in supporting documents as illustrated in subsequent chapters of the data report. By using the template, decisions by the SR-Can team are separated from expert input. This increases the traceability of assessment decisions. The data report supplies assessment data for all parts of the repository system, the fuel, the canister, the buffer and backfill and the geosphere. For the geosphere, many of the data are based on information obtained during the site investigation programme

  1. The influence of Co/Sr and Fe/Sr driers on film formation of high solid alkyd coatings.

    Science.gov (United States)

    Pirš, Barbara; Znoj, Bogdan; Skale, Saša; Zabret, Jožefa; Godnjavec, Jerneja; Berce, Peter; Venturini, Peter

    2015-01-01

    High solid (HS) alkyd resins with low amount of volatile organic compounds (VOC) were developed as the result of new VOC solvent directive that limit the amount of VOC in decorative paints. Due to specific chemical structure of HS alkyd resins and possible deterioration of some applicative properties the optimal combination of driers is an important subject of research. In our present work we studied the influence of iron (Fe) and cobalt (Co) surface driers with strontium (Sr) through drier on the film formation of HS alkyd coatings. The kinetics of autoxidation was analysed using FT-IR spectroscopy. Further, applicative properties like drying time and film hardness were examined. In the end, electrochemical impedance spectroscopy (EIS) was used to evaluate the quality of cured HS alkyd coating films after exposure in the humidity chamber. It was established that the addition of the Sr drier to surface driers accelerates the film formation process. As higher amounts of the Sr drier were added, final drying times were reduced and film hardness increased. The highest quality of cured films were observed for Co/Sr and Fe/Sr drier combination at 1:1 concentration ratio.

  2. Epitaxial growth and thermodynamic stability of SrIrO3/SrTiO3 heterostructures

    Science.gov (United States)

    Groenendijk, D. J.; Manca, N.; Mattoni, G.; Kootstra, L.; Gariglio, S.; Huang, Y.; van Heumen, E.; Caviglia, A. D.

    2016-07-01

    Obtaining high-quality thin films of 5d transition metal oxides is essential to explore the exotic semimetallic and topological phases predicted to arise from the combination of strong electron correlations and spin-orbit coupling. Here, we show that the transport properties of SrIrO3 thin films, grown by pulsed laser deposition, can be optimized by considering the effect of laser-induced modification of the SrIrO3 target surface. We further demonstrate that bare SrIrO3 thin films are subject to degradation in air and are highly sensitive to lithographic processing. A crystalline SrTiO3 cap layer deposited in-situ is effective in preserving the film quality, allowing us to measure metallic transport behavior in films with thicknesses down to 4 unit cells. In addition, the SrTiO3 encapsulation enables the fabrication of devices such as Hall bars without altering the film properties, allowing precise (magneto)transport measurements on micro- and nanoscale devices.

  3. Muon SR Newsletter, No. 29, April 5, 1984

    International Nuclear Information System (INIS)

    Crowe, K.M.; Portis, A.M.; Yamazaki, T.

    1984-01-01

    Muon SR stands for Muon Spin Relaxation, Rotation, Resonance, Research, or what have you. The intention of the mnemonic acronym is to draw attention to the analogy with NMR and ESR, the range of whose applications is well known. Any study of the interactions of the muon spin by virtue of the asymmetric decay is considered μSR, but this definition is not intended to exclude any peripherally related phenomena, especially if relevant to the use of the muon's mganetic moment as a delicate probe of matter. Abstracts of individual items from this issue were prepared separately for the data base

  4. Effect of SR manipulation on conduit artery dilation in humans.

    Science.gov (United States)

    Carter, Howard H; Dawson, Ellen A; Birk, Gurpreet K; Spence, Angela L; Naylor, Louise H; Cable, N Timothy; Thijssen, Dick H J; Green, Daniel J

    2013-01-01

    The impact of manipulating shear stress on conduit artery vasodilation has not been comprehensively described in vivo. We hypothesized that manipulation of SR through the brachial and radial arteries would be associated with corresponding changes in diameter. We performed a series of studies involving the following: (1) leg cycle exercise at increasing intensities (≈70 and 85% maximum heart rate [HRmax]) with simultaneous bilateral measurement of SR in the radial arteries; (2) leg cycle exercise for 30 minutes at 80% HRmax with simultaneous bilateral measurement of velocity and diameter in the brachial arteries; and (3) bilateral forearm heating for 30 minutes with simultaneous bilateral measurement of brachial artery diameter and blood velocity. Cycling and forearm heating interventions were performed in the presence of unilateral cuff inflation throughout the experiment, or starting during the intervention (15 minutes), to manipulate SR responses. Cuff placement was associated with lower radial artery SR responses (cuffed versus uncuffed, 248±49 versus 349±105 L/s 85% HRmax; P<0.01), and diameter responses were similarly attenuated (2.45±0.30 versus 2.78±0.20 mm 85% HRmax; P<0.05). Exercise performed at 80% HRmax in the presence of unilateral cuff inflation also reduced brachial artery SR (cuffed versus uncuffed; 258±107 versus 454±157 L/s; P<0.01) and diameter (3.96±0.39 versus 4.20±0.45 mm). Finally, cuff inflation decreased the impact of forearm heating on brachial SR (cuffed versus uncuffed; 262±97 versus 440±106 L/s; P<0.01) and diameter (4.35±0.54 versus 4.87±0.47 mm; P<0.05). Similar significant differences between the cuffed and uncuffed limbs in SR and diameter were observed when cuff inflation occurred during exercise or heating. Our findings strongly implicate SR as an important stimulus to increase conduit artery diameter in humans.

  5. Determination of Sr90 activity in human bones

    International Nuclear Information System (INIS)

    Mendonca, Anamelia Habib

    1970-01-01

    Several studies have been published in the literature on the extent and levels of radioactive contamination of food chains caused by fallout from nuclear weapon tests. According to UNSCEAR, these studies cover a great number of:-areas of the developed world, though large, areas of Asia, Africa and South-America are left aside with only, unsatisfactory information about the levels, of radioactive contamination. In 1968, UNSCEAR recommended that a survey on the contamination of biological materials such as human - bone by fission products and particularly Sr 90 should be encouraged on those areas where only fragmentary information was available. UNSCEAR recommendations call upon the fact that many individuals on such areas of the world have been exposed to Sr 90 contamination from birth to their adult area. Therefore, that group have an Sr 90 skeletal burden very much different from people exposed only at adult age. Based on these considerations, UNSCEAR recommendations called for Sr 90 analysis on human bones from different age groups. In Brazil, studies on the of Sr 90 in human bone are practically non-existent, except for the year of 1959. Following UNSCEAR recommendations, we decided to perform such a survey on Sr 90 levels in human bones. Samples were collected from individuals that died in Rio de Janeiro from accidents. These samples were firstly classified according to social level in very poor and poor groups. Samples were then classified in three age groups ranging 0-18, 18-30 and 30-40 years of age. Results show that levels found in the Brazilian age groups are close to the ones observed in Chile (1969), Argentina and Australia (1966-1968) and slightly, higher than -those observed in Venezuela, Senegal and Jamaica (1969). If one compares the results obtained for the North and South hemispheres respectively, one sees that there was a more pronounced decrease in the levels of Sr 90 content of the of some regions of South America. Our results show no

  6. Determination of 90Sr in grass and soil

    International Nuclear Information System (INIS)

    Bajo, S.; Keil, R.

    1994-10-01

    A radiochemical method for the determination of 90 Sr in non-contaminated grass and soil is presented. The method is based on the leaching of 90 Sr from the mineralized samples followed by liquid-liquid extraction of 90 Y, its short lived daughter, by tributylphosphate and precipitation of Y-oxalate, which is counted in a low-level proportional counter. Based on dried samples of 30 g of soil and 100 g of grass the limit of detection is about 0.1 Bq/kg for both materials. (author) figs., tabs., 43 refs

  7. Heat capacity of SrThO3

    International Nuclear Information System (INIS)

    Kumar, Ginish; Raut, Sheetal; Agarwal, Renu; Mukerjee, S.K.

    2016-01-01

    Thorium is more abundant in nature than uranium, therefore, it is expected to play an important role in the third stage of Indian nuclear power generation program. An advanced heavy water reactor, with thorium oxide based fuels, is being developed in India, with an aim of utilizing thorium for power generation. Alkaline earth elements, Ba and Sr, with significant fission yield (6.3%), react with fuel and precipitate out as a separate phase. Thermodynamic properties of fuel-fission product compounds are needed to understand behaviour of fuel at high burn-ups, therefore, it was decided to investigate heat capacity of SrThO 3

  8. Impact ofin vitrochemosensitivity test-guided platinum-based adjuvant chemotherapy on the surgical outcomes of patients with p-stage IIIA non-small cell lung cancer that underwent complete resection.

    Science.gov (United States)

    Akazawa, Yuki; Higashiyama, Masahiko; Nishino, Kazumi; Uchida, Jyunji; Kumagai, Toru; Inoue, Takako; Fujiwara, Ayako; Tokunaga, Toshiteru; Okami, Jiro; Imamura, Fumio; Kodama, Ken; Kobayashi, Hisayuki

    2017-09-01

    The impact of in vitro chemosensitivity test-guided platinum-based adjuvant chemotherapy on the surgical outcomes of patients undergoing complete resection for locally advanced non-small cell lung cancer (NSCLC) has yet to be elucidated. In the present study, the utility of adjuvant chemotherapy based on the collagen gel droplet embedded culture drug sensitivity test (CD-DST) in patients with p (pathology)-stage IIIA NSCLC was retrospectively analyzed. A series of 39 patients that had received platinum-based adjuvant chemotherapy following complete resection between 2007 and 2012 were enrolled. Their surgical specimens were subjected to the CD-DST. The patients were subsequently classified into two groups on the basis of in vitro anti-cancer drug sensitivity data obtained using the CD-DST: The sensitive group (25 patients) were treated with regimens including one or two of the anti-cancer drug(s) that were indicated to be effective by the CD-DST, whereas the non-sensitive group (14 patients) were treated with chemotherapy regimens that did not include any CD-DST-selected anti-cancer drugs. There were no significant differences in the background characteristics of the two groups [including in respect of the pathological TN (tumor-lymph node) stage, tumor histology, epidermal growth factor receptor mutation status, the frequency of each chemotherapy regimen, and the number of administered cycles]. The 5-year disease-free survival (DFS) rate of the sensitive group was 32.3%, whereas that of the non-sensitive group was 14.3% (P=0.037). In contrast, no difference in overall survival (OS) was observed (P=0.76). Multivariate analysis revealed that adjuvant chemotherapy based on the CD-DST had a significant favorable effect on the DFS (P=0.01). Therefore, the present study has demonstrated that CD-DST data obtained from surgical specimens aid the selection of effective platinum-based adjuvant chemotherapy regimens for patients undergoing complete resection for p-stage IIIA

  9. Study on sorption capacity and characterization of Sr2+ on synthetic zeolite

    International Nuclear Information System (INIS)

    Wang Jinming; Yi Facheng

    2010-01-01

    Sr 2+ adsorption capacity of synthetic zeolite(ZF) are studied with the intermittence method, and ZF adsorbed the Sr 2+ is characterized and analyzed by XRD, as a reference for the evaluation of the disposal effectiveness of low and medium radwastes. The results show that Sr 2+ adsorption capacity of ZF is good, and the equilibrium time for ZF to adsorb Sr 2+ is in range of 5-14 days. Sr 2+ concentration has the greatest effect on ZF adsorption capacity,and the medium,temperature and pH value of the solution also have effect on ZF adsorption capacity. With the augment of Sr 2+ concentration,the Sr 2+ equilibrium adsorption quantity of ZF increases,but the equilibrium adsorption rate and equilibrium adsorption ratio decreases. Sr 2+ adsorption capacity of ZF improves with the augment of pH value. Sr 2+ adsorption capacity of ZF is complicate and varies with the different ion, concentration and other components in the medium solution. Sr 2+ adsorption capacity of ZF increases with the augment of temperature. As a whole, when Sr 2+ concentration in the solution is 0.005mol/L, the pH value of the solution, and the temperature of medium and solution have less effect on the Sr 2+ adsorption capacity of ZF, and the unit cell parameter of ZF adsorbed Sr 2+ decreases. (authors)

  10. Modelling the Phanerozoic carbon cycle and climate - Constraints from the Sr-87/Sr-86 isotopic ratio of seawater

    Science.gov (United States)

    Francois, Louis M.; Walker, James C. G.

    1992-01-01

    A numerical model is developed for simulating the long-term changes of atmospheric CO2 and climate during the Phanerozoic. The model describes the coupled evolution of the biogeochemical cycles of C, S, Ca, Mg, P, and Sr, with the emphasis on the effect of coupling the cycles of carbon and strontium and on interpreting the observed seawater Sr-87/Sr-86 ratios. The abilities of continental weathering, volcanism, and surface lithology in generating that signal are tested and compared. The results obtained are used to reconstruct a history of atmospheric CO2 and climate during Phanerozoic time, consistent with the strontium isotopic data. It is shown that the predicted history is compatible with paleoclimatic indicators, such as the timing of glaciation and the estimates of Cretaceous paleotemperatures.

  11. Rapid determination of 90Sr in samples of urine using sorbent AnaLig Sr-01 (presentation)

    International Nuclear Information System (INIS)

    Bilohuscin, J.; Dulanska, S.; Gardonova, V.

    2013-01-01

    Sorbent of molecular recognition of AnaLig Sr-01 from IBC's Technologies was used for effectively and selectively re-concentration, separation and determination of strontium from urine samples. The method utilizes the separation using two columns, consisting of two commercial products, first from Eichrom called pre-filter material absorbing organic compounds founded in urine, such as creatine, which interfere with separation and reduce the capture efficiency of strontium on the second column, consisting of AnaLig Sr-01 sorbent.

  12. Synthesis and magnetic characterization of Sr-based Ni2X-type hexaferrite

    Directory of Open Access Journals (Sweden)

    K. Kamishima

    2015-10-01

    Full Text Available We have investigated the synthesis conditions, and the magnetic properties of the Sr2Ni2X-type hexagonal ferrite, Sr2Ni2Fe28O46. The Sr2Ni2X-type hexaferrite was synthesized at 1240∘C. The spontaneous magnetization at 5 K was 44.2 μB/f.u., suggesting that most of the Ni2+ ions are at the up-spin octahedral sites in the spinel-structure blocks within the model of a Néel-type collinear ferrimagnetic structure. The Curie temperature of the Sr2Ni2X-type hexaferrite was estimated to be TC[Sr2Ni2X] = 472∘C. This is consistent with the difference of the block stacking structures of SrM-type, Sr2Ni2X-type, SrNi2W-type, and nickel spinel ferrites.

  13. Sr isotope zoning in plagioclase from andesites at Cabo De Gata, Spai

    DEFF Research Database (Denmark)

    Waight, Tod Earle; Tørnqvist, Jakob

    2018-01-01

    Plagioclase crystals in andesites from the Cabo De Gata region show generally radiogenic Sr isotope compositions and consistent core to rim increases in 87Sr/86Sr that are indicative of open system processes in the lithosphere and crustal contamination during crystallization. High-grade metamorphic...... rocks of the Alpujárride and Nevado-Filábride complexes represent the most likely crustal contaminants. The plagioclases are characterized by subtly zoned and resorbed calcic cores (An73-86). These cores also have radiogenic 87Sr/86Sr (0.7127-0.7129), although less radiogenic than plagioclase rims......, groundmass plagioclase and whole rock compositions (up to 87Sr/86Sr = 0.7135). These cores are interpreted to represent early crystallization of plagioclase from hydrous melts emplaced into the lower crust. The parental melts to these andesites must therefore have already inherited their radiogenic Sr...

  14. Phase relations and conductivity of Sr-zirconates and La-zirconates

    DEFF Research Database (Denmark)

    Poulsen, F.W.; Vanderpuil, N.

    1992-01-01

    The formation of the strontium zirconates SrZrO3, Sr4Zr3O10, Sr3Zr2O7 and Sr2ZrO4, and of the lanthanum zirconates La2Zr2O7 and La2-xYZr2O7 at 1450-degrees-C was investigated by x-ray powder diffraction and DTA. Three different routes of synthesis were tested. In the Sr-zirconate system, single......-C. The conductivity of the Sr-zirconates increases with increasing Sr/Zr ratio. Samples with a nominal composition corresponding to Sr2ZrO4 have a conductivity of 7.5 x 10(-5) and 5.9 x 10(-4) S/cm at 750 and 1000-degrees-C, respectively. For all samples one observes low activation energies for ionic conduction (0...

  15. Tectonic forcing of early to middle jurassic seawater Sr/Ca

    DEFF Research Database (Denmark)

    Ullmann, Clemens Vinzenz; Hesselbo, Stephen P.; Korte, Christoph

    2013-01-01

    sections in the UK and Poland demonstrate that the Sr/Ca ratio of seawater varied systematically throughout the Early and Middle Jurassic in parallel with already documented seawater 87Sr/86Sr. The Sr flux from increased mid-ocean ridge activity in the Early Jurassic outbalanced the input of riverine Sr......, leading to gradually lower seawater 87Sr/86Sr associated with the parallel and strong decrease in seawater Sr/Ca ratios. This downward trend was reversed by enhanced continental input in the Toarcian and Aalenian, but resumed in the Bajocian and continued to the Callovian. Parallel changes of seawater 87...... the role of biomineral evolution in influencing strontium chemistry of seawater in the mid-Mesozoic....

  16. A novel synthesis of SrCO{sub 3}–SrTiO{sub 3} nanocomposites with high photocatalytic activity

    Energy Technology Data Exchange (ETDEWEB)

    Márquez-Herrera, A., E-mail: amarquez@ugto.mx [Universidad de Guanajuato, Departamento de Ingeniería Mecánica Agrícola, DICIVA, Campus Irapuato-Salamanca (Mexico); Ovando-Medina, Víctor M.; Castillo-Reyes, Blanca E. [Universidad Autónoma de San Luis Potosí, Ingeniería Química, COARA (Mexico); Meléndez-Lira, M. [CINVESTAV-IPN, Departamento de Física (Mexico); Zapata-Torres, M. [Centro de Investigación en Ciencia Aplicada y Tecnología Avanzada (Mexico); Saldaña, N. [Universidad de Guanajuato, Departamento de Ingeniería Mecánica Agrícola, DICIVA, Campus Irapuato-Salamanca (Mexico)

    2014-12-15

    The results of the production and characterization of SrCO{sub 3}–SrTiO{sub 3} nanocomposites as a promising candidate for efficient photocatalysts are reported. The production is based on a novelty route employing the solvothermal method with strontium chloride and titanium (IV) butoxide as the precursor solutions. The effect on the properties of the nanocomposites due to changes in the content of SrCO{sub 3} and SrTiO{sub 3} is reported. The as-prepared materials were tested in the photodegradation of methylene blue dye in aqueous solutions under the solar light. The reported route allows the production of SrCO{sub 3}–SrTiO{sub 3} nanocomposites with particle sizes ranging between 18 and 29 nm. The SrCO{sub 3}–SrTiO{sub 3} nanocomposites obtained with 19 % of SrCO{sub 3} phase and 81 % of SrTiO{sub 3} (M10) can achieve 94 and 97 % of dye photodegradation after 30 and 120 min, respectively.

  17. Using noble gases and 87Sr/86Sr to constrain heat sources and fluid evolution at the Los Azufres Geothermal Field, Mexico

    Science.gov (United States)

    Wen, T.; Pinti, D. L.; Castro, M. C.; Lopez Hernandez, A.; Hall, C. M.; Shouakar-Stash, O.; Sandoval-Medina, F.

    2017-12-01

    Geothermal wells and hot springs were sampled for noble gases' volume fraction and isotopic measurements and 87Sr/86Sr in the Los Azufres Geothermal Field (LAGF), Mexico, to understand the evolution of fluid circulation following three decades of exploitation and re-injection of used brines. The LAGF, divided into the Southern Production Zone (SPZ) and the Northern Production Zone (NPZ), is hosted in a Miocene to Pliocene andesitic volcanic complex covered by Quaternary rhyolitic-dacitic units. Air contamination corrected 3He/4He ratios (Rc) normalized to the atmospheric ratio (Ra=1.384 x 10-6), show a median value of 6.58 indicating a dominant mantle helium component. Contributions of crustal helium up to 53% and 18% are observed in NPZ and SPZ, respectively. Observations based on Rc/Ra and 87Sr/86Sr ratios points to the mixing of three magmatic sources supplying mantle helium to the LAGF: (1) a pure mantle He (Rc/Ra = 8) and Sr (87Sr/86Sr = 0.7035) source; (2) a pure mantle helium (Rc/Ra = 8) with some radiogenic Sr (87Sr/86Sr = 0.7049) source possibly resulting from Quaternary rhyolitic volcanism; and (3) a fossil mantle He component (Rc/Ra = 3.8) with some radiogenic Sr (87Sr/86Sr = 0.7038), corresponding possibly to the Miocene andesite reservoir. Intrusions within the last 50 kyrs from sources (1) and (2) are likely responsible for the addition of mantle volatiles and heat to the hydrothermal system of Los Azufres. He and Ar isotopes indicate that heat flow is transported by both convection and conduction. Atmospheric noble gas elemental ratios suggest that geothermal wells located closer to the western re-injection zone are beginning to be dominated by re-injection of used brines (injectate). The area affected by boiling in LAGF has further extended to the north and west since the last noble gas sampling campaign in 2009.

  18. mu SR in Organic and Free Radical Chemistry

    CERN Multimedia

    2002-01-01

    Experiment SC82 was begun as a simple attempt to substitute positive muons into polymer molecules, and thereby to use the @mSR technique to study the mechanical relaxation of the different molecular groups. \\\\ \\\\ The experiment has since developed in several directions and has produced a wealth of information on the properties of muonic molecules, and adequately demonstrated the potential of @mSR as applied to molecular physics and chemistry. Physics aspects are now covered by a new experiment code SC95.\\\\ \\\\ The present experiment includes studies where the position occupied by the muon in the molecule (or crystal lattice) is readily established and the @mSR signal is exploited to reveal the intrinsic properties of the material. In this respect the @mSR techniques may be regarded simply as an experimental tool to probe the molecular behaviour of a chemical system. \\\\ \\\\ Two main classes of application include the measurement of isotope effects, where differences between muonic and corresponding photonic radi...

  19. ADEPT Sounding Rocket One (SR-1)Flight Experiment Overview

    Science.gov (United States)

    Wercinski, Paul; Smith, B.; Yount, B.; Cassell, A.; Kruger, C.; Brivkalns, C.; Makino, A.; Duttta, S.; Ghassemieh, S.; Wu, S.; hide

    2017-01-01

    The SR-1 flight experiment will demonstrate most of the primary end-to-end mission stages including: launch in a stowed configuration, separation and deployment in exo-atmospheric conditions, and passive ballistic re-entry of a 70-degree half-angle faceted cone geometry.

  20. Experimental probe into adsorption of Sr, Cs in the Soil

    International Nuclear Information System (INIS)

    Yuan Guangyu; Bai Qingzhong

    1987-12-01

    There are some obstacles in researching on the adsorption patterns of Sr and Cs in soil. One of them is that it is difficult to compare and to consult between various results and data for different types and sizes of soil. For this reason, it is neccesary to do further research into adsorption patterns of Sr and Cs in single particles of soil. By using scanning electromicroscope, the microcosmic phenomena of nuclides adsorption is observed, and a possible mechanism is proposed. A certain amount of diluvial soil from Shanxi Province and a certain amount of alluvial soil from western Beijing suburban were chosen as detected samples. After determining the distributions of adsorbed Sr and Cs in varied mineral particles, it is pointed out that the defference of chemical components of various size soils effects Kd value of Sr and Cs obviously. The method for calculating Kd value of mixing samples according to the particle distribution coefficients are derived under the condition of surface adsorption as main. The authors expound that it is favourable for accuracy to select and control the particle sizes in static adsorptional experiment

  1. Synthesis of BiPbSrCaCuO superconductor

    Science.gov (United States)

    Hults, William L.; Kubat-Martin, Kimberly A.; Salazar, Kenneth V.; Phillips, David S.; Peterson, Dean E.

    1994-01-01

    A process and a precursor composition for preparing a lead-doped bismuth-strontium-calcium-copper oxide superconductor of the formula Bi.sub.a Pb.sub.b Sr.sub.c Ca.sub.d Cu.sub.e O.sub.f wherein a is from about 1.7 to about 1.9, b is from about 0.3 to about 0.45, c is from about 1.6 to about 2.2, d is from about 1.6 to about 2.2, e is from about 2.97 to about 3.2 and f is 10.+-.z by reacting a mixture of Bi.sub.4 Sr.sub.3 Ca.sub.3 Cu.sub.4 O.sub.16.+-.z, an alkaline earth metal cuprate, e.g., Sr.sub.9 Ca.sub.5 Cu.sub.24 O.sub.41, and an alkaline earth metal plumbate, e.g., Ca.sub.2-x Sr.sub.x PbO.sub.4 wherein x is about 0.5, is disclosed.

  2. Preparation structure and dielectric behaviour of the system Sr1 ...

    Indian Academy of Sciences (India)

    Unknown

    synthesised have cubic structure similar to undoped SrTiO3. Study of dielectric behaviour ... perovskite structure are useful materials because of their wide applications in the electro- nics industry. Owing to their ..... Scientist, Research Design and Standard Organisation, Lucknow and Prof D Pandey, Co- ordinator, School of ...

  3. Assessment of Sr-90 in water samples: precision and accuracy

    Energy Technology Data Exchange (ETDEWEB)

    Nisti, Marcelo B.; Saueia, Cátia H.R.; Castilho, Bruna; Mazzilli, Barbara P., E-mail: mbnisti@ipen.br, E-mail: chsaueia@ipen.br, E-mail: bcastilho@ipen.br, E-mail: mazzilli@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2017-11-01

    The study of artificial radionuclides dispersion into the environment is very important to control the nuclear waste discharges, nuclear accidents and nuclear weapons testing. The accidents in Fukushima Daiichi Nuclear Power Plant and Chernobyl Nuclear Power Plant, released several radionuclides in the environment by aerial deposition and liquid discharge, with various level of radioactivity. The {sup 90}Sr was one of the elements released into the environment. The {sup 90}Sr is produced by nuclear fission with a physical half-life of 28.79 years with decay energy of 0.546 MeV. The aims of this study are to evaluate the precision and accuracy of three methodologies for the determination of {sup 90}Sr in water samples: Cerenkov, LSC direct method and with radiochemical separation. The performance of the methodologies was evaluated by using two scintillation counters (Quantulus and Hidex). The parameters Minimum Detectable Activity (MDA) and Figure Of Merit (FOM) were determined for each method, the precision and accuracy were checked using {sup 90}Sr standard solutions. (author)

  4. On the Conditioning of Factors in the SR Decomposition

    Czech Academy of Sciences Publication Activity Database

    Fassbender, H.; Rozložník, Miroslav

    2016-01-01

    Roč. 505, 15 September (2016), s. 224-244 ISSN 0024-3795 R&D Projects: GA ČR GA13-06684S Institutional support: RVO:67985807 Keywords : SR decomposition * symplectic matrices * skew-symmetric bilinear forms * orthogonalization * condition number Subject RIV: BA - General Mathematics Impact factor: 0.973, year: 2016

  5. IR study of Pb–Sr titanate borosilicate glasses

    Indian Academy of Sciences (India)

    Administrator

    to study their structure systematically. IR spectrum of each glass composition shows a number of absorption bands. These bands are strongly influenced by the increasing substitution of SrO for PbO. Various bands shift with composition. Absorption peaks occur due to the vibrational mode of the borate network in these ...

  6. Effect of SR manipulation on conduit artery dilation in humans

    NARCIS (Netherlands)

    Carter, H.H.; Dawson, E.A.; Birk, G.K.; Spence, A.L.; Naylor, L.H.; Cable, N.T.; Thijssen, D.H.J.; Green, D.J.

    2013-01-01

    The impact of manipulating shear stress on conduit artery vasodilation has not been comprehensively described in vivo. We hypothesized that manipulation of SR through the brachial and radial arteries would be associated with corresponding changes in diameter. We performed a series of studies

  7. Lubomír Sršeň jubilant

    Czech Academy of Sciences Publication Activity Database

    Mádl, Martin

    2009-01-01

    Roč. 21, č. 2 (2009), s. 22-24 ISSN 0862-612X Institutional research plan: CEZ:AV0Z80330511 Keywords : history of art * museology * Lubomír Sršeň Subject RIV: AL - Art, Architecture, Cultural Heritage

  8. LCAO calculations of SrTiO3 nanotubes

    Science.gov (United States)

    Evarestov, Robert; Bandura, Andrei

    2011-06-01

    The large-scale first-principles simulation of the structure and stability of SrTiO3 nanotubes is performed for the first time using the periodic PBE0 LCAO method. The initial structures of the nanotubes have been obtained by the rolling up of the stoichiometric SrTiO3 slabs consisting of two or four alternating (001) SrO and TiO2 atomic planes. Nanotubes (NTs) with chiralities (n,0) and (n,n) have been studied. Two different NTs were constructed for each chirality: (I) with SrO outer shell, and (II) with TiO2 outer shell. Positions of all atoms have been optimized to obtain the most stable NT structure . In the majority of considered cases the inner or outer TiO2 shells of NT undergo a considerable reconstruction due to shrinkage or stretching of interatomic distances in the initial cubic perovskite structure. There were found two types of surface reconstruction: (1) breaking of Ti-O bonds with creating of Ti = O titanyl groups in outer surface; (2) inner surface folding due to Ti-O-Ti bending. Based on strain energy calculations the largest stability was found for (n,0) NTs with TiO2 outer shell.

  9. LCAO calculations of SrTiO{sub 3} nanotubes

    Energy Technology Data Exchange (ETDEWEB)

    Evarestov, Robert; Bandura, Andrei, E-mail: re1973@re1973.spb.edu [Department of Quantum Chemistry, St. Petersburg State University, 26 Universitetsky Ave., 198504, Petrodvorets (Russian Federation)

    2011-06-23

    The large-scale first-principles simulation of the structure and stability of SrTiO{sub 3} nanotubes is performed for the first time using the periodic PBE0 LCAO method. The initial structures of the nanotubes have been obtained by the rolling up of the stoichiometric SrTiO{sub 3} slabs consisting of two or four alternating (001) SrO and TiO{sub 2} atomic planes. Nanotubes (NTs) with chiralities (n,0) and (n,n) have been studied. Two different NTs were constructed for each chirality: (I) with SrO outer shell, and (II) with TiO{sub 2} outer shell. Positions of all atoms have been optimized to obtain the most stable NT structure . In the majority of considered cases the inner or outer TiO{sub 2} shells of NT undergo a considerable reconstruction due to shrinkage or stretching of interatomic distances in the initial cubic perovskite structure. There were found two types of surface reconstruction: (1) breaking of Ti-O bonds with creating of Ti = O titanyl groups in outer surface; (2) inner surface folding due to Ti-O-Ti bending. Based on strain energy calculations the largest stability was found for (n,0) NTs with TiO{sub 2} outer shell.

  10. Measurement of 90Sr in fresh water samples

    International Nuclear Information System (INIS)

    Belanova, A.; Meresova, J.; Svetlik, I.; Tomaskova, L.

    2008-01-01

    This preliminary study show new experimental approach to the determination of the radionuclide 90 Sr in water samples. The new method of dynamic windows utilizing liquid scintillation counting was applied on model and surface water samples. Our results show the demand of separation technique with significantly higher yields. (authors)

  11. IR study of Pb–Sr titanate borosilicate glasses

    Indian Academy of Sciences (India)

    Administrator

    IR study of Pb–Sr titanate borosilicate glasses. C R GAUTAM*, DEVENDRA KUMAR. † and OM PARKASH. †. Department of Physics, University of Lucknow, Lucknow 226 007, India. †. Department of Ceramic Engineering, Institute of Technology, Banaras Hindu University, Varanasi 221 005, India. MS received 3 January ...

  12. A compilation of Sr and Nd isotope data on Mexico

    International Nuclear Information System (INIS)

    Verma, S.P.; Verma, M.P.

    1986-01-01

    A compilation is given of the available Sr and Nd isotope data on Mexican volcanic-plutonic terranes which cover about one-third of Mexico's territory. The available data are arranged according to a subdivision of the Mexican territory in terms of geological provinces. Furthermore, site and province averages and standard deviations are calculated and their petrogenetic implications are pointed out. (author)

  13. 90Sr and 137Cs content in fishes

    International Nuclear Information System (INIS)

    Patin, S.A.; Petrov, A.A.

    1978-01-01

    Numerous data are presented and discussed on concentrations of 90 Sr in bones and 137 Cs in muscular tissues of main food fishes fished out in different regions of the ocean, seas, lakes and rivers. They are indicative of the absence of appreciable hygienic hazards for man from eating food fishes

  14. Traveling-wave deceleration of SrF molecules

    NARCIS (Netherlands)

    van den Berg, J.E.; Chirayath Mathavan, Sreekanth; Meinema, C.; Nauta, Janko; Nijbroek, T. H.; Jungmann, K.; Bethlem, H. L.; Hoekstra, S.

    We report on the production, deceleration and detection of a SrF molecular beam. The molecules are captured from a supersonic expansion and are decelerated in the X-2 Sigma(+) (v = 0, N = 1) state. We demonstrate the removal of up to 40% of the kinetic energy with a 2 m long modular traveling-wave

  15. Extreme heterogeneity in Sr isotope systematic in the Himalayan ...

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Earth System Science; Volume 110; Issue 2. Extreme heterogeneity in Sr isotope systematic in the Himalayan leucogranites: A possible mechanism of partial melting based on thermal modeling. Dilip K Mukhopadhyay. Volume 110 Issue 2 June 2001 pp 161-169 ...

  16. PLA2 polymorphism of platelet glycoprotein IIb/IIIa but not Factor V Leiden and prothrombin G20210A polymorphisms is associated with venous thromboembolism and more recurrent events in central Iran.

    Science.gov (United States)

    Pourgheysari, Batoul; Boroujeni, Hamid Rouhi; Hasheminia, Ali Mohammad; Drees, Fatima

    2013-07-01

    Inherited thrombophilic gene polymorphisms have been linked to the pathogenesis of venous thromboembolism (VTE). As there are very limited data of these polymorphisms in the Iranian population, we aimed to investigate the correlation between them and VTE in central Iran. Seventy-two unrelated VTE patients and 306 healthy control individuals were recruited for the study. Genotyping from venous blood with EDTA for the factor V Leiden (FVL), prothrombin (FII) G20210A, methylenetetrahydrofolate reductase (MTHFR) C677T and PLA2 polymorphism of platelet glycoprotein IIb/IIIa were undertaken by PCR-restriction fragment length polymorphism (PCR-RFLP). A total of 57 investigated polymorphisms with a mean of 0.79 per individual and 151 with a mean of 0.49 were found in patients and controls, respectively (Pgenetic risk factor (P=0.007) and more recurrent events occurred in such patients. Patients with PLA2 polymorphism had more recurrent events than the other patients (P=0.02). Patients with more than one genetic risk factor and recurrent events were younger. The prevalence of these polymorphisms is different from some previously published data in other populations, but is consistent with some others. Higher prevalence of PLA2 polymorphism of GPIIa/IIIb in VTE patients is indicative of the impact of this polymorphism in the pathogenesis of VTE in this population. Because of the impact of coinheritance on the recurrence and the age of occurrence, such patients may need to be managed differently.

  17. Multicenter Phase II Study Evaluating Two Cycles of Docetaxel, Cisplatin and Cetuximab as Induction Regimen Prior to Surgery in Chemotherapy-Naive Patients with NSCLC Stage IB-IIIA (INN06-Study.

    Directory of Open Access Journals (Sweden)

    Wolfgang Hilbe

    Full Text Available Different strategies for neoadjuvant chemotherapy in patients with early stage NSCLC have already been evaluated. The aim of this study was to evaluate the tolerability and efficacy of a chemoimmunotherapy when limited to two cycles.Between 01/2007 and 03/2010 41 patients with primarily resectable NSCLC stage IB to IIIA were included. Treatment consisted of two cycles cisplatin (40 mg/m2 d1+2 and docetaxel (75 mg/m2 d1 q3 weeks, accompanied by the administration of cetuximab (400 mg/m2 d1, then 250 mg weekly. The primary endpoint was radiological response according to RECIST.40 patients were evaluable for toxicity, 39 for response. The main grade 3/4 toxicities were: neutropenia 25%, leucopenia 11%, febrile neutropenia 6%, nausea 8% and rash 8%. 20 patients achieved a partial response, 17 a stable disease, 2 were not evaluable. 37 patients (95% underwent surgery and in three of them a complete pathological response was achieved. At a median follow-up of 44.2 months, 41% of the patients had died, median progression-free survival was 22.5 months.Two cycles of cisplatin/ docetaxel/ cetuximab showed promising efficacy in the neoadjuvant treatment of early-stage NSCLC and rapid operation was possible in 95% of patients. Toxicities were manageable and as expected.EU Clinical Trials Register; Eudract-Nr: 2006-004639-31.

  18. General regularities of Sr 90 distribution in system soil-plant under natural conditions

    International Nuclear Information System (INIS)

    Gudeliene, I.; Marchiulioniene, D.; Petroshius, R.

    2006-01-01

    Sr 90 distribution in system 'soil - underground part of plant - aboveground part of plant' was investigated. It was determined that Sr 90 activity concentration in underground and aboveground part of plants and in mosses was not dependent on its activity concentration in soil. There was direct dependence of Sr 90 activity concentration in aboveground on underground parts of plants. Sr 90 transfer factor from soil to underground part of plants and mosses was directly dependent on this radionuclide activity concentration in them. (authors)

  19. Determination of 89,90Sr in complex samples

    International Nuclear Information System (INIS)

    Grahek, Zeljko

    2008-01-01

    Full text: Among all radionuclides which are released into nature one of the three most studied is 90 Sr. Reason for this lies in the fact that radioactive strontium isotopes are highly radiotoxic fission products (especially 90 Sr with long half life), and as such they were an interesting subject for various kinds of investigations, from their distribution and behavior in natural systems to their influence on human health. As a rule, the determination of radioactive strontium is complicated and time-consuming, especially if isotope 89 Sr is present in sample. Therefore, the main purpose of this work is a describing and comparing the some novel procedures for 'rapid' radioactive strontium determination. In one procedure, strontium is isolated from samples on the column filled with Sr resin by binding of strontium to the resin and successive elution with HNO 3 . In the second method strontium and yttrium are bound on to anion exchange column from alcoholic solutions of nitric acid. The optimum mixture of alcohols for sample binding is a mixture of ethanol and methanol with the volume ratio 1:3. Strontium and yttrium are separated from Mg, Ca, K, and other elements by elution with 0.25M HNO 3 in the mixture of ethanol and methanol. It is shown that the procedure with the Sr resin is simpler and faster in the phase of the isolation on the column in comparison with the procedure with the anion exchanger. The procedure with the mixed solvent anion exchange, however, enables the simultaneous isolation of yttrium and strontium and rapid determination of 89 , 90 Sr. The described methods were tested by determining of 89 , 90 Sr in different kind of samples (some obtained from Environmental Measurement Laboratory, USA). It is also shown that the efficiency of isolation on the column depends on and separation conditions on the both column; as a rule, strontium recovery strongly depends on column dimension and kind of sample. Therefore it is showed how experimental data and

  20. Mg and Sr in Arctic echinoderm calcite: Nature or nurture?

    Science.gov (United States)

    Iglikowska, A.; Borszcz, T.; Drewnik, A.; Grabowska, M.; Humphreys-Williams, E.; Kędra, M.; Krzemińska, M.; Piwoni-Piórewicz, A.; Kukliński, P.

    2018-04-01

    The Mg/Ca and Sr/Ca ratios in echinoderm skeletal calcite are used as a proxy for Phanerozoic seawater changes, since the skeletal concentrations are, to some extent, controlled by environmental factors. However, it remains unclear how the influence of environmental factors is modified by vital effects, especially in polar waters. Therefore, the goal of this study was to compare the ratios of Mg/Ca and Sr/Ca among the skeletal parts of 10 common Arctic echinoderm species belonging to three classes Echinoidea, Asteroidea and Ophiuroidea that contribute substantially to the carbon cycle in the Arctic benthic system. Significant differences were recorded in echinoid skeletal element concentrations among specific skeletal parts. The lowest Mg/Ca and Sr/Ca ratios were detected in the spines (mean Mg/Ca 37.5 ± 8.8 SD; Sr/Ca 1.8 ± 0.1). The components of the Aristotle's lantern (epiphyses, pyramids and rotulas) were characterised by the highest Mg levels (Mg/Ca 79.9 ± 6.0; 75.2 ± 9.1; 60.1 ± 3.8, respectively). It is likely that mouth parts experience greater mechanical pressure compared to other body parts, and the higher content of Mg in the Aristotle's lantern contributes to its robustness. We did not find any distinctive trends in the distribution of skeletal elements in the asteroid and ophiuroid skeletal parts. The heterogeneous concentrations of Mg and Sr in different skeleton parts of the echinoids suggest possible physiological regulation of the chemical composition rather than the composition only being influenced by the environment. We cannot recommend echinoderm skeletons as reliable indicators in palaeoenvironmental reconstructions due to the possible biological control of skeletal chemistry, which may interfere with the effect of environmental variables.

  1. Characterization of Sr9h, a wheat stem rust resistance allele effective to Ug99.

    Science.gov (United States)

    Rouse, Matthew N; Nirmala, Jayaveeramuthu; Jin, Yue; Chao, Shiaoman; Fetch, Thomas G; Pretorius, Zacharias A; Hiebert, Colin W

    2014-08-01

    Wheat stem rust resistance gene SrWeb is an allele at the Sr9 locus that confers resistance to Ug99. Race TTKSK (Ug99) of Puccinia graminis f. sp. tritici, the causal fungus of stem rust, threatens global wheat production because of its broad virulence to current wheat cultivars. A recently identified Ug99 resistance gene from cultivar Webster, temporarily designated as SrWeb, mapped near the stem rust resistance gene locus Sr9. We determined that SrWeb is also present in Ug99 resistant cultivar Gabo 56 by comparative mapping and an allelism test. Analysis of resistance in a population segregating for both Sr9e and SrWeb demonstrated that SrWeb is an allele at the Sr9 locus, which subsequently was designated as Sr9h. Webster and Gabo 56 were susceptible to the Ug99-related race TTKSF+ from South Africa. Race TTKSF+ possesses unique virulence to uncharacterized Ug99 resistance in cultivar Matlabas. This result validated that resistance to Ug99 in Webster and Gabo 56 is conferred by the same gene: Sr9h. The emergence of pathogen virulence to several resistance genes that are effective to the original Ug99 race TTKSK, including Sr9h, suggests that resistance genes should be used in combinations in order to increase resistance durability.

  2. Characterising the stable δ88/86Sr isotopic composition in rainwater, southwestern Taiwan

    Science.gov (United States)

    Chao, Hung-Chun; Hsiao, Cheng-Hung; You, Chen-Feng; Huang, Chun-Chang; Chung, Chuan-Hsiung

    2017-04-01

    Radiogenic and stable Sr isotopes provide important information on chemical wreathing. However, our knowledge on the characteristic of stable Sr isotopes of rainwater, the major source of river water, is limited. More than 300 rainwater samples were collected manually and their major, trace elements, δD, δ18O, 87Sr/86Sr, and δ88Sr were determined. Two major moisture sources are differentiated based on the seasons and d-excess value, namely polar continental air mass (Pc; winter) and equatorial maritime air mass (Em; summer). The stable Sr isotopes show large variations (0.10 to 0.39 ‰) compared to other studied materials such as rocks, river water, seawater, carbonates and so on. Pc has δ88Sr distributed between 0.10 and 0.29 ‰, distinguishable and slightly lower than Em, which is distributed between 0.18 and 0.39 ‰. The δ88Sr values of Pc samples show moderate correlations with δD, δ18O, 87Sr/86Sr, Na/Sr ratio, and Sr concentration. On the other hand, Em samples show no correlation with those factors. In summary, Em samples may be contributed by sea-salt and various local signals while Pc samples show stronger lithological signal which is contributed by long range transport dusts.

  3. The influence of Sr on the microstructure, degradation and stress corrosion cracking of the Mg alloys - ZK40xSr.

    Science.gov (United States)

    Chen, Lianxi; Bin, Yuanhong; Zou, Wenqi; Wang, Xiaojian; Li, Wei

    2017-02-01

    In the present work, new magnesium (Mg) alloys (Mg-4Zn-0.6Zr-xSr, x=0, 0.4, 0.8, 1.2, 1.6wt%; ZK40xSr) were prepared and studied as potential biodegradable materials. The influence of strontium (Sr) addition on the properties of the new Mg alloys was investigated, which included microstructure, corrosion degradation, and the stress corrosion cracking (SCC) susceptibility. The average grain size of the ZK40Sr was approximately 100µm, which was significantly smaller than that of ZK40 alloy without Sr (402.3±40.2µm). The size of grain boundaries precipitates in the ZK40xSr alloys gradually increased with the increase of Sr content. The grain boundaries finally showed a continuously distribution and net-like shape. The degradation test showed that the average degradation rate of the ZK40xSr alloys increased with the increase of Sr addition. In the case of Mg-4Zn-0.6Zr, the degradation rate was 2.2mgcm -2 day -1 , which was lower than that of Mg-4Zn-0.6Zr-1.6Sr (4.93mgcm -2 day -1 ). When the ZK40xSr alloys were immersed in m-SBF, the rod-like Sr-contained hydroxyapatite (HA) substance was detected, which was known to enhance cell growth around bone implants. The fracture surfaces of the as-cast Mg-4Zn-0.6Zr-1.6Sr were shown intergranular stress corrosion cracking (IGSCC) patterns. The increase of SCC susceptibility of the higher Sr ZK40xSr alloys was attributed to the increase of micro-galvanic corrosion between the α-Mg and the grain boundaries precipitates. The SCC susceptibility values were ≈0.13 and ≈0.41 for the Mg-4Zn-0.6Zr-0.4Sr and the Mg-4Zn-0.6Zr-1.6Sr, respectively. Copyright © 2016 Elsevier Ltd. All rights reserved.

  4. SR-A ligand and M-CSF dynamically regulate SR-A expression and function in primary macrophages via p38 MAPK activation

    Directory of Open Access Journals (Sweden)

    Du Liqin

    2011-07-01

    Full Text Available Abstract Background Inflammation is characterized by dynamic changes in the expression of cytokines, such as M-CSF, and modifications of lipids and proteins that result in the formation of ligands for Class A Scavenger Receptors (SR-A. These changes are associated with altered SR-A expression in macrophages; however, the intracellular signal pathways involved and the extent to which SR-A ligands regulate SR-A expression are not well defined. To address these questions, SR-A expression and function were examined in resident mouse peritoneal macrophages incubated with M-CSF or the selective SR-A ligand acetylated-LDL (AcLDL. Results M-CSF increased SR-A expression and function, and required the specific activation of p38 MAPK, but not ERK1/2 or JNK. Increased SR-A expression and function returned to basal levels 72 hours after removing M-CSF. We next determined whether prolonged incubation of macrophages with SR-A ligand alters SR-A expression. In contrast to most receptors, which are down-regulated by chronic exposure to ligand, SR-A expression was reversibly increased by incubating macrophages with AcLDL. AcLDL activated p38 in wild-type macrophages but not in SR-A-/- macrophages, and p38 activation was specifically required for AcLDL-induced SR-A expression. Conclusions These results demonstrate that in resident macrophages SR-A expression and function can be dynamically regulated by changes in the macrophage microenvironment that are typical of inflammatory processes. In particular, our results indicate a previously unrecognized role for ligand binding to SR-A in up-regulating SR-A expression and activating p38 MAPK. In this way, SR-A may modulate inflammatory responses by enhancing macrophage uptake of modified protein/lipid, bacteria, and cell debris; and by regulating the production of inflammatory cytokines, growth factors, and proteolytic enzymes.

  5. Sr isotope tracing of multiple water sources in a complex river system, Noteć River, central Poland

    International Nuclear Information System (INIS)

    Zieliński, Mateusz; Dopieralska, Jolanta; Belka, Zdzislaw; Walczak, Aleksandra; Siepak, Marcin; Jakubowicz, Michal

    2016-01-01

    Anthropogenic impact on surface waters and other elements in the environment was investigated in the Noteć River basin in central Poland. The approach was to trace changes in the Sr isotope composition ( 87 Sr/ 86 Sr) and concentration in space and time. Systematic sampling of the river water shows a very wide range of 87 Sr/ 86 Sr ratios, from 0.7089 to 0.7127. This strong variation, however, is restricted to the upper course of the river, whereas the water in the lower course typically shows 87 Sr/ 86 Sr values around 0.7104–0.7105. Variations in 87 Sr/ 86 Sr are associated with a wide range of Sr concentrations, from 0.14 to 1.32 mg/L. We find that strong variations in 87 Sr/ 86 Sr and Sr concentrations can be accounted for by mixing of two end-members: 1) atmospheric waters charged with Sr from the near-surface weathering and wash-out of Quaternary glaciogenic deposits, and 2) waters introduced into the river from an open pit lignite mine. The first reservoir is characterized by a low Sr content and high 87 Sr/ 86 Sr ratios, whereas mine waters display opposite characteristics. Anthropogenic pollution is also induced by extensive use of fertilizers which constitute the third source of Sr in the environment. The study has an important implication for future archeological studies in the region. It shows that the present-day Sr isotope signatures of river water, flora and fauna cannot be used unambiguously to determine the “baseline” for bioavailable 87 Sr/ 86 Sr in the past. - Highlights: • Sr isotopes fingerprint water sources and their interactions in a complex river system. • Mine waters and fertilizers are critical anthropogenic additions in the river water. • Limited usage of environmental isotopic data in archeological studies. • Sr budget of the river is dynamic and temporary.

  6. Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR family splicing factors from nuclear speckles

    International Nuclear Information System (INIS)

    Lin, C.-L.; Leu, Steve; Lu, M.-C.; Ouyang Pin

    2004-01-01

    Pre-mRNA splicing takes place within a dynamic ribonucleoprotein particle called the spliceosome and occurs in an ordered pathway. Although it is known that spliceosome consists of five small nuclear RNAs and at least 50 proteins, little is known about how the interaction among the proteins changes during splicing. Here we identify that SR-cyp, a Moca family of nuclear cyclophilin, interacts and colocalizes with nuclear pinin (pnn), a SR-related protein involving in pre-mRNA splicing. Nuclear pnn interacts with SR-cyp via its C-terminal RS domain. Upon SR-cyp over-expression, however, the subnuclear distribution of nuclear pnn is altered, resulting in its redistribution from nuclear speckles to a diffuse nucleoplasmic form. The diffuse subnuclear distribution of nuclear pnn is not due to epitope masking, accelerated protein turnover or post-translational modification. Furthermore, we find that SR-cyp regulates the subnuclear distribution of other SR family proteins, including SC35 and SRm300, in a similar manner as it does on nuclear pnn. This result is significant because it suggests that SR-cyp plays a general role in modulating the distribution pattern of SR-like and SR proteins, similar to that of Clk (cdc2-like kinase)/STY on SR family splicing factors. SR-cyp might direct its effect via either alteration of protein folding/conformation or of protein-protein interaction and thus may add another control level of regulation of SR family proteins and modification of their functions

  7. Human SR-BI and SR-BII potentiate LPS-induced inflammation and acute liver and kidney injury in mice

    Science.gov (United States)

    Baranova, Irina N.; Souza, Ana C. P.; Bocharov, Alexander V.; Vishnyakova, Tatyana G.; Hu, Xuzhen; Vaisman, Boris L.; Amar, Marcelo J.; Chen, Zhigang; Kost, Yana; Remaley, Alan T.; Patterson, Amy P.; Yuen, Peter S. T.; Star, Robert A.; Eggerman, Thomas L.

    2016-01-01

    The class B scavenger receptors BI (SR-BI) and BII (SR-BII) are HDL receptors that recognize various pathogens, including bacteria and their products. It has been reported that SR-BI/II-null mice are more sensitive than normal mice to endotoxin-induced inflammation and sepsis. Since the SR-BI/II-knockout model demonstrates multiple immune and metabolic disorders we investigated the role of each receptor in the LPS-induced inflammatory response and tissue damage using transgenic mice with pLiv-11-directed expression of human SR-BI or SR-BII. Six hours after intraperitoneal LPS injection, transgenic hSR-BI and hSR-BII mice demonstrated markedly higher serum levels of pro-inflammatory cytokines and 2-3-fold increased expression levels of inflammatory mediators in the liver and kidney, compared to wild type (WT) mice. LPS-stimulated iNOS expression was 3-6-fold higher in the liver and kidney of both transgenic strains, although serum NO levels were similar in all mice. Despite the lower HDL plasma levels, both transgenic strains responded to LPS by a 5-fold increase of plasma corticosterone levels which were only moderately lower than in WT animals. LPS treatment resulted in MAPKs activation in tissues of all mice; however, the strongest response was detected for hepatic ERK1/2 and kidney JNK of both transgenic mice. Histological examination of hepatic and renal tissue from LPS-challenged mice revealed more injury in hSR-BII but not hSR-BI transgenic mice vs WT controls. Our findings demonstrate that hSR-BII, and to a lesser extent hSR-BI, significantly increase LPS-induced inflammation and contribute to LPS-induced tissue injury in the liver and kidney, two major organs susceptible to LPS toxicity. PMID:26936883

  8. Preparation of Sr7Mn4O13F2 by the topotactic reduction and subsequent fluorination of Sr7Mn4O15.

    Science.gov (United States)

    Saratovsky, Ian; Lockett, Michelle A; Rees, Nicholas H; Hayward, Michael A

    2008-06-16

    The topotactic reduction and subsequent fluorination of Sr7Mn4O15 yields a phase of composition Sr7Mn4O13F2. Characterization of this phase utilizing powder neutron diffraction and 19F NMR shows that the fluoride ions are located on a single anion site, the same crystallographic site that is vacant in the reduced intermediate Sr7Mn4O13.

  9. SR-BI as target in atherosclerosis and cardiovascular disease - A comprehensive appraisal of the cellular functions of SR-BI in physiology and disease.

    Science.gov (United States)

    Hoekstra, Menno

    2017-03-01

    High-density lipoprotein (HDL) is considered an anti-atherogenic lipoprotein species due to its role in reverse cholesterol transport. HDL delivers cholesterol esters to the liver through selective uptake by scavenger receptor class B type I (SR-BI). In line with the protective role for HDL in the context of cardiovascular disease, studies in mice and recently also in humans have shown that a disruption of normal SR-BI function predisposes subjects to the development of atherosclerotic lesions and cardiovascular disease. Although SR-BI function has been studied primarily in the liver, it should be acknowledged that the SR-BI protein is expressed in multiple tissues and cell types across the body, albeit at varying levels between the different tissues. Given that SR-BI is widely expressed throughout the body, multiple cell types and tissues can theoretically contribute to the atheroprotective effect of SR-BI. In this review the different functions of SR-BI in normal physiology are highlighted and the (potential) consequences of cell type-specific disruption of SR-BI function for atherosclerosis and cardiovascular disease susceptibility discussed. It appears that hepatocyte and platelet SR-BI inhibit respectively the development of atherosclerotic lesions and thrombosis, suggesting that SR-BI located on these cell compartments should be regarded as being a protective factor in the context of cardiovascular disease. The relative contribution of SR-BI present on endothelial cells, steroidogenic cells, adipocytes and macrophages to the pathogenesis of atherosclerosis and cardiovascular disease remains less clear, although proper SR-BI function in these cells does appear to influence multiple processes that impact on cardiovascular disease susceptibility. Copyright © 2017 The Author. Published by Elsevier B.V. All rights reserved.

  10. The coprecipitation of Sr2+ with calcite at 250C and 1 atm

    International Nuclear Information System (INIS)

    Pingitore, N.E. Jr.; Eastman, M.P.

    1986-01-01

    The incorporation of Sr 2+ into calcite at earth surface aqueous conditions is affected by the absolute concentration of Sr 2+ , the presence of Ba 2+ and NaCl in the solution and the rate of precipitation. At solution ratios (molar) of Sr 2+ to Ca 2+ in the low 10 -3 range, which yield calcites with several hundred ppm Sr 2+ , kappasub(calcite) sup(Sr) typically assumes a value between 0.10 and 0.20. Above these concentrations the value of kappasub(calcite) sup(Sr) drops to approximately 0.06. Furthermore, if minor amounts of Ba 2+ or large amounts of Na + (0.48 M) are added to a dilute Sr 2+ solution, a value around 0.06 for kappasub(calcite)sup(Sr) is found. This 'strontium concentration effect' and the associated 'competitive cation effect' suggest that small amounts of Sr 2+ may be incorporated into a limited number of nonlattice sites in calcite. Incorporation of Sr 2+ into these sites, presumably defects, noticeably affects kappasub(calcite)sup(Sr) only at low Sr 2+ concentrations and in the absence of competition from other large cations. An increase in kappasub(calcite)sup(Sr) with rate of precipitation, qualitatively similar to that found in other studies, was observed only when precipitation times were decreased from days to hours. For many geologic settings a partition coefficient for Sr 2+ into calcite of 0.06 appears appropriate, but there are situations - very low Sr 2+ concentrations, the presence of Mg 2+ , and fast precipitation rates - in which a larger value might better approximate natural partitioning. (author)

  11. Quasi-two-dimensional Fermi-liquid state in Sr2RhO4-δ

    International Nuclear Information System (INIS)

    Nagai, Ichiro; Shirakawa, Naoki; Umeyama, Norio; Ikeda, Shin-ichi

    2010-01-01

    Single crystals of layered perovskite Sr 2 RhO 4-δ (δ=0.0 and 0.1) are successfully grown by the floating-zone method. Stoichiometric single crystals (Sr 2 RhO 4.0 ) are obtained by O 2 -annealing the as-grown crystals (Sr 2 RhO 3.9 ). Sr 2 RhO 4.0 and Sr 2 RhO 3.9 show quasi-two-dimensional Fermi-liquid behavior at low temperatures, whereas there are large differences in the anisotropy of electrical resistivity ρ c (3 K)/ρ ab (3 K) and Wilson ratio R w between Sr 2 RhO 4.0 and Sr 2 RhO 3.9 : ρ c (3 K)/ρ ab (3 K)=2400 (19000) and R w =3.8 (6.4) for Sr 2 RhO 4.0 (Sr 2 RhO 3.9 ). The differences observed between the temperature dependence of the in-plane electrical resistivity (T 2 RhO 4.0 and Sr 2 RhO 3.9 are mainly derived from those between the density of states and band structure near the corresponding Fermi level. This indicates that the changes in these physical properties, which are accompanied by oxygen defects in the Sr 2 RhO 4-δ system, can be explained by the rigid band model. Moreover, these results suggest that t 2g band-filling can be controlled by adjusting the oxygen defect content δ in the Sr 2 RhO 4-δ system. Although many similarities are observed in this study between the physical properties of Sr 2 RhO 4.0 and Sr 2 RuO 4 . Sr 2 RhO 4.0 does not exhibit superconductivity down to 36 mK. (author)

  12. Micron SR Studies of High Critical Temperature Superconductor Lead

    Science.gov (United States)

    Wu, Wei-Dong

    1995-01-01

    Flux depinning phenomena in the rm Bi_2Sr_2CaCu_2O_8 (Bi2212) and rm Pb_{0.7}Bi_ {1.3}Sr_2CaCu_2O_8 (Pb-Bi2212) systems have been studied using the technique of transverse field (TF) muSR. Comparison of field-cooled (FC) and zero-field-cooled (ZFC) results defines an irreversibility (depinning) temperature T _{rm irr}: the ZFC and FC relaxation rates are essentially identical above T _{rm irr}, while the ZFC relaxation rate is larger than the FC relaxation rate below T_{rm irr}, reflecting the increased inhomogeneity of the local fields in the ZFC measurements due to flux pinning. The irreversibility line T_{irr}(H) of Bi2212 obtained by muSR measurements is compared with those from dc and ac-susceptibility, and mechanical oscillator measurements. I show that the results from muSR and these other techniques can be explained consistently within a framework of the flux creep model. The irreversibility temperature in Pb -Bi2212, determined by muSR measurements, is significantly higher than that in the pure Bi2212 system. This result, together with the larger critical current and the higher activation energy U_0 in the Pb-Bi2212 crystals as found by the dc-susceptibility measurements, suggests an enhancement of flux pinning by the Pb doping. In order to fit the muSR asymmetry measured in Y_{1-x} U_{x}Pd _3, I have performed Monte Carlo simulations for spin glasses with impurity concentration x between 0 and 1; I found that the stretched exponential decay of muon polarisation found empirically in many spin glasses above the spin freezing temperature T_{g } is consistent with a lognormal distribution of the fluctuation rate nu. Our muSR measurements of Y_ {1-x}U_{x}Pd _3 and UPd_4 demonstrate the disappearance of magnetic order with decreasing U concentration x with a threshold U concentration x _{rm th} ~ 0.2. I show that the behavior is consistent with Sherrington's induced spin glass model based on the competition between exchange interaction coupling {cal T } and the

  13. SR 97 - Waste, repository design and sites. Background report to SR 97 SKB

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-10-01

    SR 97 is a comprehensive analysis of long-term safety of a deep repository for spent nuclear fuel. The repository is assumed to be designed according to the KBS-3 method. Assessments are performed in SR 97 for three fictitious sites: Aberg, Beberg and Ceberg. One premise is that data used for assessment of the fictitious sites are to be taken from sites that have previously been investigated. The spent nuclear fuel is enclosed in copper canisters with an insert of cast iron. The canisters are emplaced in bored holes in the floor of the deposition tunnels. Around each canister, bentonite blocks are stacked which, after absorbing water and swelling, will isolate the canister from groundwater, hold the canister in place and retard transport of radionuclides from the canister to the surrounding rock. The spent nuclear fuel will emit heat fora long time, due to the decay heat. The maximum permissible temperature on the canister surface has been chosen at 100 deg C. The spacing between the deposition holes and between the deposition tunnels is adjusted site-specifically to meet this requirement. The thermal properties of the rock and the buffer material are of importance for how closely the deposition holes and tunnels can be spaced. After deposition, the deposition tunnels are backfilled with a mixture of bentonite and crushed rock. SR 97 examines above all the consequences of various scenarios and the handling of various types of uncertainties. The different repository sites illustrate normal properties for Swedish bedrock which are of importance for safety. To facilitate the work, the repositories on the three sites are configured as similarly as possible, which means for example that they are located at roughly the same depth and are fitted into the bedrock in a relatively similar fashion. Apart from the siting of a repository for spent nuclear fuel, the site may need to house a separate repository for other long-lived waste. This possibility has been considered in

  14. Atomic layer epitaxy of Ruddlesden-Popper SrO(SrTiO{sub 3}){sub n} films by means of metalorganic aerosol deposition

    Energy Technology Data Exchange (ETDEWEB)

    Jungbauer, M.; Hühn, S.; Moshnyaga, V. [Erstes Physikalisches Institut, Universität Göttingen, Friedrich-Hund-Platz 1, 37077 Göttingen (Germany); Egoavil, R.; Tan, H.; Verbeeck, J.; Van Tendeloo, G. [EMAT, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp (Belgium)

    2014-12-22

    We report an atomic layer epitaxial growth of Ruddlesden-Popper (RP) thin films of SrO(SrTiO{sub 3}){sub n} (n = ∞, 2, 3, 4) by means of metalorganic aerosol deposition (MAD). The films are grown on SrTiO{sub 3}(001) substrates by means of a sequential deposition of Sr-O/Ti-O{sub 2} atomic monolayers, monitored in-situ by optical ellipsometry. X-ray diffraction and transmission electron microscopy (TEM) reveal the RP structure with n = 2–4 in accordance with the growth recipe. RP defects, observed by TEM in a good correlation with the in-situ ellipsometry, mainly result from the excess of SrO. Being maximal at the film/substrate interface, the SrO excess rapidly decreases and saturates after 5–6 repetitions of the SrO(SrTiO{sub 3}){sub 4} block at the level of 2.4%. This identifies the SrTiO{sub 3} substrate surface as a source of RP defects under oxidizing conditions within MAD. Advantages and limitations of MAD as a solution-based and vacuum-free chemical deposition route were discussed in comparison with molecular beam epitaxy.

  15. Geochemical tracing of As pollution in the Orbiel Valley (southern France): 87Sr/86Sr as a tracer of the anthropogenic arsenic in surface and groundwater.

    Science.gov (United States)

    Khaska, Mahmoud; Le Gal La Salle, Corinnne; Lancelot, Joël; Verdoux, Patrick; Boutin, René

    2014-05-01

    The environmental impacts of arsenic mining activities and their effects on ecosystem and human health are observed in many stream waters and groundwater. The aim of this study is to identify the origin of As content in a mining environment using Sr isotopes. At the Salsigne gold mine, before the closure in 2004, high arsenic content has been observed in surface water and groundwater in the Orbiel valley. At the site, immobilization of As, in As rich leachate, is carried out by adding CaO. High contrast in 87Sr/86Sr between Arsenic rich minerals associated with Variscan metamorphic rocks (0.714888-0.718835), together with rich As waste water (0.713463-715477), and the CaO (0.707593) allows as to trace the origin of anthropogenic As. In 2012, Orbiel stream waters were sampled monthly upstream and downstream from the ancient ore processing site and once after an important rainy event (117mm). The upstream valley samples showed low and relatively constant As content with natural regional background of 3.6 and 5.6 μg/L. The rainy event induced only a slight increase in the As content up to 6.3 μg/L. High 87Sr/86Sr ratios suggested an influence of radiogenic Sr issued from the Variscan metamorphic basement. Downstream from the area, the As content was at least10 time as high. In the wet season, stream water As content clearly increased to 13.9-24 μg/L, reaching 120.5 μg/L during the rainy event. Associated 87Sr/86Sr ratio showed to be less radiogenic (0.712276-0.714002). The anti correlation observed between As and 87Sr/86Sr suggest that As issued from a natural origin is characterised by a high 87Sr/86Sr compared to As derived from the CaO treatement used on site and characterized by a low 87Sr/86Sr ratio. During the dry season, increase in As content was observed reaching 110 μg/L. These highlights the contribution of alluvial groundwater to base flow, probably associated with As reach leachate from the site. Contribution from the alluvial aquifer is confirmed by

  16. Interim main report of the safety assessment SR-Can

    International Nuclear Information System (INIS)

    Hedin, Allan

    2004-08-01

    This document is an interim report on the safety assessment SR-Can (SR in the acronym stands for Safety Report and Can is short for canister). The final SR-Can report will support SKB's application to build an Encapsulation plant for spent nuclear fuel and is to be produced in 2006. The purpose of the present interim report is to demonstrate the methodology for safety assessment so that it can be reviewed before it is used in a license application. The assessment relates to the KBS-3 disposal concept in which copper canisters with a cast iron insert containing spent nuclear fuel are surrounded by bentonite clay and deposited at approximately 500 m depth in saturated, granitic rock. Preliminary data from the Forsmark site, presently being investigated by SKB as one of the candidate for a KBS-3 repository are used to some extent as examples. However, the collected data are yet too sparse to allow an evaluation of safety for this site. An important aim of this report is to demonstrate the proper handling of requirements on the safety assessment in applicable regulations. Therefore, regulations issued by the Swedish Nuclear Power Inspectorate and the Swedish Radiation Protection Authority are duplicated in an Appendix. The principal acceptance criterion requires that 'the annual risk of harmful effects after closure does not exceed 10 -6 for a representative individual in the group exposed to the greatest risk'. 'Harmful effects' refer to cancer and hereditary effects. Following the introductory chapter 1, this report outlines the methodology for the SR-Can assessment in chapter 2, and presents in chapters 3, 4 and 5 the initial state of the system and the plans and methods for handling external influences and internal processes, respectively. Function indicators are introduced in chapter 6 and a preliminary evaluation of these is given in chapter 7. The material presented in the first seven chapters is utilised in the scenario selection in chapter 8. Hydrogeological

  17. Interim main report of the safety assessment SR-Can

    Energy Technology Data Exchange (ETDEWEB)

    Hedin, Allan (ed.) [and others

    2004-08-01

    This document is an interim report on the safety assessment SR-Can (SR in the acronym stands for Safety Report and Can is short for canister). The final SR-Can report will support SKB's application to build an Encapsulation plant for spent nuclear fuel and is to be produced in 2006. The purpose of the present interim report is to demonstrate the methodology for safety assessment so that it can be reviewed before it is used in a license application. The assessment relates to the KBS-3 disposal concept in which copper canisters with a cast iron insert containing spent nuclear fuel are surrounded by bentonite clay and deposited at approximately 500 m depth in saturated, granitic rock. Preliminary data from the Forsmark site, presently being investigated by SKB as one of the candidate for a KBS-3 repository are used to some extent as examples. However, the collected data are yet too sparse to allow an evaluation of safety for this site. An important aim of this report is to demonstrate the proper handling of requirements on the safety assessment in applicable regulations. Therefore, regulations issued by the Swedish Nuclear Power Inspectorate and the Swedish Radiation Protection Authority are duplicated in an Appendix. The principal acceptance criterion requires that 'the annual risk of harmful effects after closure does not exceed 10{sup -6} for a representative individual in the group exposed to the greatest risk'. 'Harmful effects' refer to cancer and hereditary effects. Following the introductory chapter 1, this report outlines the methodology for the SR-Can assessment in chapter 2, and presents in chapters 3, 4 and 5 the initial state of the system and the plans and methods for handling external influences and internal processes, respectively. Function indicators are introduced in chapter 6 and a preliminary evaluation of these is given in chapter 7. The material presented in the first seven chapters is utilised in the scenario selection

  18. Sr isotopic microsampling of magmatic rocks; a review (Invited)

    Science.gov (United States)

    Davidson, J. P.

    2010-12-01

    Sr isotopes have been used since the 1960s as powerful tracers of source for igneous rocks. In the past 10 years in-situ isotopic microsampling has afforded us tremendous progress in our capacity to understand magmatic processes. This progress is underpinned by analytical advances particularly in sample extraction through laser or micromill and in multicollector mass spectrometer improvements to sensitivity and precision. Perhaps the biggest surprise was the recognition in the 1990s that young magmatic rocks are commonly isotopically heterogeneous at the component (inter- or intra- crystal) scale. Given that melting and fractionation do not affect 87Sr/86Sr we would not a priori expect isotopic variations within or among crystals in a young igneous rock. This observation alone attests to open system behavior in magmas, and tells us that many of the crystals have been mechanically aggregated and not grown directly from the melt in which they are found solidified (a conclusion that can also commonly be drawn from cursory petrographic examination). This recognition in turn means that we can make use of the crystals as recorders of the isotopic environments in which they crystallise: If a crystal grows progressively from a melt which changes its isotopic composition through processes such as contamination and mixing, then the only record of the melt evolution is in the core-rim compositions of the crystals - analogous to the environmental record of tree rings. Plagioclase crystals in mafic enclaves from Lassen (CA) and Purico-Chascon (Chile), for instance, have isotopic records that reflect origination from the more silicic host. Core-rim records of evolution can also be integrated with textural measurements. At Stromboli we have shown how isotopic zoning correlates with crystal size distribution. The detailed records of single crystals can be complemented by multi crystal core analyses which can be used to distinguish specific populations. This approach was used on

  19. New aragonite 87Sr/86Sr records of Mesozoic ammonoids and approach to the problem of N, O, C and Sr isotope cycles in the evolution of the Earth

    Science.gov (United States)

    Zakharov, Yuri D.; Dril, Sergei I.; Shigeta, Yasunari; Popov, Alexander M.; Baraboshkin, Eugenij Y.; Michailova, Irina A.; Safronov, Peter P.

    2018-02-01

    New Sr isotope data from well-preserved aragonite ammonoid shell material from the Mesozoic are compared with that from a living Nautilus shell. The prominent negative Sr isotope excursions known from the Middle Permian, Jurassic and Cretaceous probably have their origins in intensive plate tectonic activity, followed by enhanced hydrothermal activity at the mid-ocean ridges (mantle volcanism) which supplied low radiogenic Sr to seawater. The maximum positive (radiogenic) shift in the lower Mesozoic Sr isotope curve (Lower Triassic peak) was likely caused by a significant expansion of dry land surfaces (Dabie-Sulu Triassic orogeny) and their intensive silicate weathering in conditions of extreme warming and aridity in the very end of the Smithian, followed by warm and humid conditions in the late Spathian, which apparently resulted in a significant oceanic input of radiogenic Sr through riverine flux. The comparatively high 87Sr/86Sr ratio obtained from the living Nautilus shell is probably a function of both the Alpine orogeny, which was accompanied by significant continental weathering and input of radiogenic Sr to the oceans, and the weakening of mantle volcanism.

  20. The F-BAR domains from srGAP1, srGAP2 and srGAP3 regulate membrane deformation differently

    Science.gov (United States)

    Coutinho-Budd, Jaeda; Ghukasyan, Vladimir; Zylka, Mark J.; Polleux, Franck

    2012-01-01

    Summary Coordination of membrane deformation and cytoskeletal dynamics lies at the heart of many biological processes critical for cell polarity, motility and morphogenesis. We have recently shown that Slit-Robo GTPase-activating protein 2 (srGAP2) regulates neuronal morphogenesis through the ability of its F-BAR domain to regulate membrane deformation and induce filopodia formation. Here, we demonstrate that the F-BAR domains of two closely related family members, srGAP1 and srGAP3 [designated F-BAR(1) and F-BAR(3), respectively] display significantly different membrane deformation properties in non-neuronal COS7 cells and in cortical neurons. F-BAR(3) induces filopodia in both cell types, though less potently than F-BAR(2), whereas F-BAR(1) prevents filopodia formation in cortical neurons and reduces plasma membrane dynamics. These three F-BAR domains can heterodimerize, and they act synergistically towards filopodia induction in COS7 cells. As measured by fluorescence recovery after photobleaching, F-BAR(2) displays faster molecular dynamics than F-BAR(3) and F-BAR(1) at the plasma membrane, which correlates well with its increased potency to induce filopodia. We also show that the molecular dynamic properties of F-BAR(2) at the membrane are partially dependent on F-Actin. Interestingly, acute phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] depletion in cells does not interfere with plasma membrane localization of F-BAR(2), which is compatible with our result showing that F-BAR(2) binds to a broad range of negatively-charged phospholipids present at the plasma membrane, including phosphatidylserine (PtdSer). Overall, our results provide novel insights into the functional diversity of the membrane deformation properties of this subclass of F-BAR-domains required for cell morphogenesis. PMID:22467852

  1. Strontium in coral aragonite: 3. Sr coordination and geochemistry in relation to skeletal architecture

    Science.gov (United States)

    Allison, Nicola; Finch, Adrian A.; Newville, Matthew; Sutton, Stephen R.

    2005-08-01

    Use of the coral Sr palaeothermometer assumes that the Sr in coral skeletons is substituted randomly for Ca in the aragonite structure. The presence of Sr in additional phases e.g., strontianite, or the non random distribution of Sr across metal sites in aragonite, would complicate the Sr/Ca-sea surface temperature relationship. We have used Sr K-edge microEXAFS (extended X-ray absorption fine structure) to determine the structural state of Sr across selected microvolumes of four coral skeletons ( Porites lobata, Acropora palmata, Pavona clavus, and Montastrea annularis). We used a 5 × 3 μm beam to analyse specific areas of the coral skeletal architecture, i.e., centres of calcification, fasciculi, and dissepiments. All EXAFS analyses refine, within error, to an ideally substituted Sr in aragonite, and we found no evidence of strontianite or partly ordered structural states. Anisotropy in the first shell responses results from the fact that the analysed microvolumes are not necessarily averaged for the responses of all crystal orientations in the aragonite. Although secondary ion mass spectrometry confirmed that Sr/Ca composition can vary substantially between skeletal components, we find no evidence for any contrast in Sr structural state. Sr heterogeneity may result from kinetic effects, reflecting complex disequilibrium processes during crystal precipitation, or biological effects, resulting from variations in the composition of the calcifying fluid which are biologically mediated.

  2. Experimental investigation and thermodynamic calculation of the Mg-Sr-Zr system

    International Nuclear Information System (INIS)

    Zhou, Hua; Chen, Chong; Du, Yong; Central South Univ., Hunan; Gong, Haoran

    2016-01-01

    Both experimental investigation and thermodynamic calculation were performed for the Mg-Sr-Zr system. Four decisive alloys were firstly selected and prepared using a powder metallurgy method to measure the isothermal section at 400 C via a combination of X-ray diffraction and electron probe microanalysis. No ternary compound has been observed for this ternary system. Four three-phase regions, (Mg) + (αZr) + Mg 17 Sr 2 , Mg 17 Sr 2 + (αZr) + Mg 38 Sr 9 , Mg 38 Sr 9 + (αZr) + Mg 23 Sr 6 , and Mg 23 Sr 6 + (αZr) + Mg 2 Sr, have been identified at 400 C. No appreciable ternary solubility has been detected in the binary Mg-Sr compounds. Phase transition temperatures of the Mg-Sr-Zr alloys were measured by means of differential scanning calorimetry. The thermodynamic calculations match well with the experimental data in the present work, indicating that no ternary thermodynamic parameters are needed for the thermodynamic description of this ternary system. In order to verify the reliability of the current thermodynamic calculations of the Mg-Sr-Zr system, eight as-cast alloys in the Mg-rich corner were also prepared. The calculated liquidus projection is consistent with the observed primary phase regions. The present thermodynamic calculations are reliable and can be used in the development of Mg alloys.

  3. Effect of Sr on the properties of Ce–Zr–La mixed oxides

    Directory of Open Access Journals (Sweden)

    RICHUAN RAO

    2006-03-01

    Full Text Available Ce–Zr–La–Sr mixed oxides, with different Sr contents, were prepared by the sol–gel method. In a flow-system microreactor, the reduction properties and the oxygen storage capacity (OSC of the Ce–Zr–La–Sr mixed oxides were investigated by a temperature programmed reduction (TPR and a pulse technique. It was shown that the properties of the Ce–Zr–La mixed oxides depend on the Sr content and that the optimum Sr content in the Ce–Zr–La–Sr mixed oxide is 3 mol%. The Ce–Zr–La–Sr mixed oxides doped with 3 mol% Sr (Ce0.52Zr0.4La0.05Sr0.03O1.945 has the largest specific surface area and better reduction properties and oxygen storage capacity in comparison to the other investigated samples. The XRD results of the Ce–Zr–La–Sr mixed oxides showed that their X-ray diffraction patterns are well in agreement with that of fluorite-type CeO2 with Sr ions incorporated into the Ce–Zr–La mixed oxide structures. With increasing calcination temperature, the intensity of the X-ray diffraction peaks increased, but no new peaks were observed. All of these indicate that the synthesized samples had good thermal stability.

  4. Mechanism of oxidation protection of the Si(001) surface by sub-monolayer Sr template

    Energy Technology Data Exchange (ETDEWEB)

    Fredrickson, Kurt D.; Seo, Hosung; Demkov, Alexander A., E-mail: demkov@physics.utexas.edu [Department of Physics, The University of Texas at Austin, Austin, Texas 78712 (United States)

    2016-08-14

    We investigate theoretically the oxidation stability of the Si(001) (2 × 1) reconstructed surface passivated by Sr. Using density functional theory, we find that the Sr surface with ½ monolayer of Sr is protected against oxidation. The presence of Sr delays the oxidation of the surface dimer, and even when the dimer is oxidized, O does not react with the back-bond, preventing the unwanted vertical growth of SiO{sub 2}. We also show that ¼ monolayer of Sr protects the Si surface in a different way. In the presence of ¼ monolayer of Sr, O atoms are attracted to the Sr-Si dimer complexes, thus preventing the formation of SiO{sub 2}.

  5. Laser ablation inductively coupled plasma mass spectrometry. An alternative technique for monitoring 90Sr

    International Nuclear Information System (INIS)

    TsingHai Wang; Yan-Chen Lai; Yi-Kong Hsieh; Chu-Fang Wang

    2017-01-01

    Developing a rapid detection method for monitoring released 90 Sr remains a challenge to analytical chemists, particularly considering its low concentration and significant interferences in environmental samples. We proposed a concept as an alternative to detect 90 Sr on the surface of fish scales using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). The high affinity of fish scales to Sr is capable of preconcentrating 90 Sr that minimizes isobaric interferences from 90 Zr + or 89 YH + , while tailing effect by abundant 88 Sr can be effectively reduced by adjusting the forward power of ICP-MS component. Adopting dried droplets of internal standards further allows a semiquantification of 90 Sr content on the surface of fish scales, which also arises an opportunity to monitoring the bioaccumulation of 90 Sr after Fukushima Daiichi nuclear disaster. (author)

  6. Sr-containing hydroxyapatite: morphologies of HA crystals and bioactivity on osteoblast cells

    Energy Technology Data Exchange (ETDEWEB)

    Aina, Valentina [Department of Chemistry, Università degli Studi di Torino, Via P. Giuria 7, 10125 Torino (Italy); Centre of Excellence NIS (Nanostructured Interfaces and Surface) Università degli Studi di Torino (Italy); INSTM (Italian National Consortium for Materials Science and Technology), UdR Università di Torino (Italy); Bergandi, Loredana, E-mail: loredana.bergandi@unito.it [Department of Oncology, Università degli Studi di Torino, Via Santena 5/bis, 10126 Torino (Italy); Lusvardi, Gigliola; Malavasi, Gianluca [Department of Chemical and Geological Sciences, Università di Modena and Reggio Emilia, Via Campi 183, 41125 Modena (Italy); Imrie, Flora E.; Gibson, Iain R. [School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD (United Kingdom); Cerrato, Giuseppina [Department of Chemistry, Università degli Studi di Torino, Via P. Giuria 7, 10125 Torino (Italy); Centre of Excellence NIS (Nanostructured Interfaces and Surface) Università degli Studi di Torino (Italy); INSTM (Italian National Consortium for Materials Science and Technology), UdR Università di Torino (Italy); Ghigo, Dario [Department of Oncology, Università degli Studi di Torino, Via Santena 5/bis, 10126 Torino (Italy)

    2013-04-01

    A series of Sr-substituted hydroxyapatites (HA), of general formula Ca{sub (10−x)}Sr{sub x}(PO{sub 4}){sub 6}(OH){sub 2}, where x = 2 and 4, were synthesized by solid state methods and characterized extensively. The reactivity of these materials in cell culture medium was evaluated, and the behavior towards MG-63 osteoblast cells (in terms of cytotoxicity and proliferation assays) was studied. Future in vivo studies will give further insights into the behavior of the materials. A paper by Lagergren et al. (1975), concerning Sr-substituted HA prepared by a solid state method, reports that the presence of Sr in the apatite composition strongly influences the apatite diffraction patterns. Zeglinsky et al. (2012) investigated Sr-substituted HA by ab initio methods and Rietveld analyses and reported changes in the HA unit cell volume and shape due to the Sr addition. To further clarify the role played by the addition of Sr on the physico-chemical properties of these materials we prepared Sr-substituted HA compositions by a solid state method, using different reagents, thermal treatments and a multi-technique approach. Our results indicated that the introduction of Sr at the levels considered here does influence the structure of HA. There is also evidence of a decrease in the crystallinity degree of the materials upon Sr addition. The introduction of increasing amounts of Sr into the HA composition causes a decrease in the specific surface area and an enrichment of Sr-apatite phase at the surface of the samples. Bioactivity tests show that the presence of Sr causes changes in particle size and/or morphology during soaking in MEM solution; on the contrary the morphology of pure HA does not change after 14 days of reaction. The presence of Sr, as Sr-substituted HA and SrCl{sub 2,} in cultures of human MG-63 osteoblasts did not produce any cytotoxic effect. In fact, Sr-substituted HA increased the proliferation of osteoblast cells and enhanced cell differentiation: Sr in

  7. Uptake indexes of 90Sr in the countries with various nutrition types

    International Nuclear Information System (INIS)

    Knizhnikov, V.N.; Marej, A.N.; Borisov, B.K.; Petukhova, Eh.V.

    1980-01-01

    90 Sr uptake in the human organism in the USSR and a number of countries with a western type of nitrition is studied for the period from 1963 to 1971. The following indexes are presented: the observed ratio (OR), which is 90 Sr in a skeleton/ 90 Sr in a diet pCi/gCa/pCi/gCa. This index depends largely on the level of calcium content in the diet. The index of buildup multiplicity is used to characterize 90 Sr uptake irrespective of calcium content in the diet. These indexes are used to compare 90 Sr uptake in France, USA, USSR, FRG. Factors which affect 90 Sr uptake connected with nutrition peculiarities and 90 Sr form in the diet, are presented

  8. Epitaxial growth and electronic structure of oxyhydride SrVO{sub 2}H thin films

    Energy Technology Data Exchange (ETDEWEB)

    Katayama, Tsukasa; Chikamatsu, Akira, E-mail: chikamatsu@chem.s.u-tokyo.ac.jp; Yamada, Keisuke; Onozuka, Tomoya [Department of Chemistry, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033 (Japan); Shigematsu, Kei [Kanagawa Academy of Science and Technology, Kawasaki, Kanagawa 213-0012 (Japan); Minohara, Makoto; Kumigashira, Hiroshi [Institute of Materials Structure Science, High Energy Accelerator Research Organization (KEK), Tsukuba, Ibaraki 305-0801 (Japan); Ikenaga, Eiji [Japan Synchrotron Radiation Research Institute (JASRI)/SPring-8, Mikazuki-cho, Hyogo 679-5198 (Japan); Hasegawa, Tetsuya [Department of Chemistry, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033 (Japan); Kanagawa Academy of Science and Technology, Kawasaki, Kanagawa 213-0012 (Japan)

    2016-08-28

    Oxyhydride SrVO{sub 2}H epitaxial thin films were fabricated on SrTiO{sub 3} substrates via topotactic hydridation of oxide SrVO{sub 3} films using CaH{sub 2}. Structural and composition analyses suggested that the SrVO{sub 2}H film possessed one-dimensionally ordered V-H{sup −}-V bonds along the out-of-plane direction. The synthesis temperature could be lowered by reducing the film thickness, and the SrVO{sub 2}H film was reversible to SrVO{sub 3} by oxidation through annealing in air. Photoemission and X-ray absorption spectroscopy measurements revealed the V{sup 3+} valence state in the SrVO{sub 2}H film, indicating that the hydrogen existed as hydride. Furthermore, the electronic density of states was highly suppressed at the Fermi energy, consistent with the prediction that tetragonal distortion induces metal to insulation transition.

  9. Provenancing fish in freshwaters of the Alpine Foreland using Sr/Ca and 87Sr/86Sr ratios in otoliths and otolith shape parameters

    Directory of Open Access Journals (Sweden)

    Johannes Oehm

    2015-12-01

    Although the studied freshwaters were located only in a 50 km range around lake Chiemsee on a similar geological background, differences in water chemistry, fish otolith chemistry and shape were identified. Species specific differences in reflection of the Sr/Ca ratio of a specific water body were detected. Microchemical and morphological otoliths analyses complemented each other and allowed assigning fish to specific groups of waters of origin. This information provides an important basis for the further application of otolith chemistry and shape analysis in the Alpine foreland for a diverse range of ecological questions.

  10. Multipolar Polarizabilities and Hyperpolarizabilities in the Sr Optical Lattice Clock

    Science.gov (United States)

    Porsev, S. G.; Safronova, M. S.; Safronova, U. I.; Kozlov, M. G.

    2018-02-01

    We address the problem of the lattice Stark shifts in the Sr clock caused by the multipolar M 1 and E 2 atom-field interactions and by the term nonlinear in lattice intensity and determined by the hyperpolarizability. We develop an approach to calculate hyperpolarizabilities for atoms and ions based on a solution of the inhomogeneous equation which allows us to effectively and accurately carry out complete summations over intermediate states. We apply our method to the calculation of the hyperpolarizabilities for the clock states in Sr. We also carry out an accurate calculation of the multipolar polarizabilities for these states at the magic frequency. Understanding these Stark shifts in optical lattice clocks is crucial for further improvement of the clock accuracy.

  11. The absolute frequency of the 87Sr optical clock transition

    DEFF Research Database (Denmark)

    Campbell, Gretchen K.; Ludlow, Andrew D.; Blatt, Sebastian

    2008-01-01

    The absolute frequency of the 1S0–3P0 clock transition of 87Sr has been measured to be 429 228 004 229 873.65 (37) Hz using lattice-confined atoms, where the fractional uncertainty of 8.6 × 10-16 represents one of the most accurate measurements of an atomic transition frequency to date. After...... a detailed study of systematic effects, which reduced the total systematic uncertainty of the Sr lattice clock to 1.5 × 10-16, the clock frequency is measured against a hydrogen maser which is simultaneously calibrated to the US primary frequency standard, the NIST Cs fountain clock, NIST-F1. The comparison...... is made possible using a femtosecond laser based optical frequency comb to phase coherently connect the optical and microwave spectral regions and by a 3.5 km fibre transfer scheme to compare the remotely located clock signals....

  12. Novel Osteointegrative Sr-Substituted Apatitic Cements Enriched with Alginate

    Directory of Open Access Journals (Sweden)

    Simone Sprio

    2016-09-01

    Full Text Available The present work describes the synthesis of novel injectable, self-setting bone cements made of strontium-substituted hydroxyapatite (Sr-HA, obtained by single-phase calcium phosphate precursors doped with different amounts of strontium and enriched with alginate. The addition of alginate improved the injectability, cohesion, and compression strength of the cements, without affecting the hardening process. A Sr-HA cement exhibiting adequate hardening times and mechanical strength for clinical applications was further tested in vivo in a rabbit model, in comparison with a commercial calcium phosphate cement, revealing the maintenance of biomimetic composition and porous microstructure even after one month in vivo, as well as enhanced ability to induce new bone formation and penetration.

  13. Basic properties of Sr{sub 1-x}Ba{sub x}Si{sub 2}

    Energy Technology Data Exchange (ETDEWEB)

    Imai, Motoharu, E-mail: IMAI.Motoharu@nims.go.jp; Sato, Akira; Kimura, Takashi; Aoyagi, Takeshi

    2011-10-03

    Basic properties, such as the phase relationship, crystal structure, and energy gap E{sub g}, have been investigated in Sr-rich Sr{sub 1-x}Ba{sub x}Si{sub 2}. Sr{sub 1-x}Ba{sub x}Si{sub 2} (0 {<=} x {<=} 1.0) has two phases: one with the SrSi{sub 2}-type structure and another with the BaSi{sub 2}-type structure. The SrSi{sub 2} phase exists at x ranging from 0 to 0.13, and the BaSi{sub 2} phase exists at x ranging from 0.24 to 1.0. The volume increases with x in both the SrSi{sub 2} and BaSi{sub 2} phases. A volume jump of 13.7% appears at the structural phase transition from the SrSi{sub 2} phase to the BaSi{sub 2} phase. E{sub g} increases with x in SrSi{sub 2}-phase Sr{sub 1-x}Ba{sub x}Si{sub 2} but E{sub g} decreases with x in the BaSi{sub 2}-phase Sr{sub 1-x}Ba{sub x}Si{sub 2}. In Sr-rich BaSi{sub 2}-phase Sr{sub 1-x}Ba{sub x}Si{sub 2}, Ba atoms at a specific crystallographic site, the A1 site, are preferentially substituted by Sr atoms, as well as in Ba-rich BaSi{sub 2}-phase Sr{sub 1-x}Ba{sub x}Si{sub 2}.

  14. 87Sr/88Sr a useful tool for the identification of geographic origin of Styrian pumpkin seed oils?

    Science.gov (United States)

    Meisel, T.; Bandoniene, D.; Zettl, D.; Maneiko, M.; Horschinegg, M.

    2012-04-01

    The authenticity and the geographic origin of Styrian pumpkin seed oil (PGI) a regional specialty needs to be protected, but the current specification of this high priced product does not include the proof of origin through analytical tools. As it turns out, this and many other products within the Protected Geographical Status (PGS) framework of the European Union, cannot be protected from fraud without forensic tools. In previous studies we were able to demonstrate, that distribution and content of trace elements in particular the rare earth elements, are useful parameters to discriminate Austrian from non-Austrian pumpkin seed oils and seeds. Unlike stable isotopes ratios (C and H), the trace element patterns are not influenced by changes in weather conditions and temperature during growing and harvesting cycle. Though the study of the distribution of element traces can be used not only for the identification of the geographic origin with very useful PLS and PCA models but also can identify fraud through mixing with other oils, this method need to be validated by other means. Radiogenic isotopes, in particular the 87Sr/86Sr isotope amount ratio has been successfully applied to food and other products for forensic studies. In this study we determined the 87Sr/86Sr isotope amount ratio in pumpkin seed oils extracted from seeds of known geographic origin from Austria, Russia and China, as these are the largest producers, to see if significant differences occur and if they can be used as a forensic tool. Although the total area of the Russian and the Chinese crop fields are magnitudes larger than the ones from Austria, it turns out that the variance of the Austrian 87Sr/86Sr data is much larger than that from other sources. Reasons are the large diversity of the Austrian geology (pre-varsican, alpine to sub-recent ages of the underlying bedrock of the soils can be found), the small farm sizes and the small scale production. In Russia large farms are situated on

  15. Thermal infrared and microwave absorbing properties of SrTiO{sub 3}/SrFe{sub 12}O{sub 19}/polyaniline nanocomposites

    Energy Technology Data Exchange (ETDEWEB)

    Hosseini, Seyed Hossein, E-mail: shhosseini@iiau.ac.ir [Department of Chemistry, Faculty of Science, Islamshahr Branch, Islamic Azad University, Tehran (Iran, Islamic Republic of); Zamani, Parisa [Department of Applied Chemistry, Faculty of Pharmaceutical Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran (Iran, Islamic Republic of); Mousavi, S.Y. [Faculty of Passive Defense, Imam Hossein University, Tehran (Iran, Islamic Republic of)

    2015-09-25

    Graphical abstract: We have developed a new perspective of applications and properties of conducting polymers. The combination of absorption ability prepared nanocomposites in the present of PANI display a great potential in organization of shielding structures into thermal IR and microwave. Further investigations using other conducting polymers to demonstrate their capability for advance thermal IR and microwave shielding devices is under way. The application of these samples may improve the IR thermographic detection, catalysis, sensors, magnetic data storage, electromagnetic resonance wave absorption, photonic crystals, and microelectronic devices and military aspects. - Highlights: • The SrTiO{sub 3}/SrFe{sub 12}O{sub 19}/PANI exhibited electric and electromagnetic properties. • The SrTiO{sub 3}/SrFe{sub 12}O{sub 19}/PANI has shielding structures into thermal IR and microwave. • Increasing weight ratios and thicknesses will increase thermal IR ability. • Increasing weight ratios and thicknesses will increase microwave absorption ability. - Abstract: Polyaniline (PANI) as a unique polymer that also has electromagnetic absorption used as the substrate. In this research, SrTiO{sub 3} was synthesized as IR absorbent and core and then SrFe{sub 12}O{sub 19} as microwave absorbent was prepared on SrTiO{sub 3} via co-precipitation method as the first shell. As the next step, PANI was coated on SrTiO{sub 3}/SrFe{sub 12}O{sub 19} nanoparticles via in situ polymerization by multi core–shell structures (SrTiO{sub 3}/SrFe{sub 12}O{sub 19}/PANI). Nanometer size and structures of samples were measured by TEM, XRD and FTIR. Morphology of nanocomposite was showed by SEM images. The magnetic and electric properties were also performed by VSM and four probe techniques. Thermal infrared (IR) absorption and microwave reflection loss of nanocomposites were investigated at 10–40 μm and 8–12 GHz, IR and microwave frequencies, respectively. The results showed that the Sr

  16. High magnetic field μSR instrument scientific case

    International Nuclear Information System (INIS)

    Amato, A.

    2005-10-01

    In order to gain more insight into the specific behavior of materials, it is often necessary to perform measurements as a function of different external parameters. Despite its high sensitivity to internal fields, this simple observation also applies for the μSR technique. The most common parameter which can be tuned during an experiment is the sample temperature. By using a range of cryostats, temperatures between 0.02 and 900 K can be covered at the PSI μSR Facility. On the other hand, and by using high-energy muons, pressures as high as 10'000 bars can nowadays be reached during μSR experiments. As will be demonstrated in the following Sections, the magnetic field is an additional external parameter playing a fundamental role when studying the ground state properties of materials in condensed matter physics and chemistry. However, the availability of high magnetic fields for μSR experiments is still rather limited. Hence, if on one hand the high value of the gyromagnetic ratio of the muon provides the high magnetic sensitivity of the method, on the other hand it can lead to very high muon-spin precession frequencies when performing measurements in applied fields (the muon-spin precession frequency in a field of 1 Tesla s 135.5 MHz). Consequently, the use of ultra-fast detectors and electronics is mandatory when measuring in magnetic fields exceeding 1 Tesla. If such fields are very intense when compared to the Earth magnetic field -4 Tesla), the energy associated with them is still modest in view of the thermal energy. Hence, the Zeeman energy splitting of a free electron in a magnetic field of 1 Tesla corresponds to a thermal energy as low as 0.67 Kelvin. It is worth mentioning that nowadays magnetic fields of the order of 10 to 15 Tesla are quite common in condensed matter laboratories and have opened up vast new exciting experimental possibilities. (author)

  17. High magnetic field {mu}SR instrument scientific case

    Energy Technology Data Exchange (ETDEWEB)

    Amato, A

    2005-10-15

    In order to gain more insight into the specific behavior of materials, it is often necessary to perform measurements as a function of different external parameters. Despite its high sensitivity to internal fields, this simple observation also applies for the {mu}SR technique. The most common parameter which can be tuned during an experiment is the sample temperature. By using a range of cryostats, temperatures between 0.02 and 900 K can be covered at the PSI {mu}SR Facility. On the other hand, and by using high-energy muons, pressures as high as 10'000 bars can nowadays be reached during {mu}SR experiments. As will be demonstrated in the following Sections, the magnetic field is an additional external parameter playing a fundamental role when studying the ground state properties of materials in condensed matter physics and chemistry. However, the availability of high magnetic fields for {mu}SR experiments is still rather limited. Hence, if on one hand the high value of the gyromagnetic ratio of the muon provides the high magnetic sensitivity of the method, on the other hand it can lead to very high muon-spin precession frequencies when performing measurements in applied fields (the muon-spin precession frequency in a field of 1 Tesla s 135.5 MHz). Consequently, the use of ultra-fast detectors and electronics is mandatory when measuring in magnetic fields exceeding 1 Tesla. If such fields are very intense when compared to the Earth magnetic field < 10{sup -4} Tesla), the energy associated with them is still modest in view of the thermal energy. Hence, the Zeeman energy splitting of a free electron in a magnetic field of 1 Tesla corresponds to a thermal energy as low as 0.67 Kelvin. It is worth mentioning that nowadays magnetic fields of the order of 10 to 15 Tesla are quite common in condensed matter laboratories and have opened up vast new exciting experimental possibilities. (author)

  18. SR-Site groundwater flow modelling methodology, setup and results

    Energy Technology Data Exchange (ETDEWEB)

    Selroos, Jan-Olof (Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden)); Follin, Sven (SF GeoLogic AB, Taeby (Sweden))

    2010-12-15

    As a part of the license application for a final repository for spent nuclear fuel at Forsmark, the Swedish Nuclear Fuel and Waste Management Company (SKB) has undertaken three groundwater flow modelling studies. These are performed within the SR-Site project and represent time periods with different climate conditions. The simulations carried out contribute to the overall evaluation of the repository design and long-term radiological safety. Three time periods are addressed; the Excavation and operational phases, the Initial period of temperate climate after closure, and the Remaining part of the reference glacial cycle. The present report is a synthesis of the background reports describing the modelling methodology, setup, and results. It is the primary reference for the conclusions drawn in a SR-Site specific context concerning groundwater flow during the three climate periods. These conclusions are not necessarily provided explicitly in the background reports, but are based on the results provided in these reports. The main results and comparisons presented in the present report are summarised in the SR-Site Main report.

  19. Electromagnetic transition strengths in 75Kr and 79Sr

    International Nuclear Information System (INIS)

    Cardona, M.A.; Filevich, Alberto; Garcia Bermudez, Gerardo; Achterberg, Erhard

    1989-01-01

    Experimental and theoretical studies of nuclear structure in light Kr and Sr isotopes have revealed a region of large quadrupole deformation. In this work, deformation properties of odd-nuclei 75 Kr and 79 Sr have been investigated. For this purpose, lifetime of excited states in both nuclei have been measured by means of the recoil distance Doppler shift technique. These nuclei were populated via the reactions: 54 Fe( 24 Mg,2pn) 75 Kr at 75 MeV and 54 Fe( 28 Si,2pn) 79 Sr at 97 MeV, the beams were provided by the Tandar accelerator. The experimental B(E2) values for these nuclei were well reproduced in the framework of the triaxial-rotor-plus quasiparticle model. In order to fix the parameters of the model a study of neighboring even-even Kr isotopes was performed. The whole N=3 and N=4 oscillator shell was used for the space configuration of the odd particle for negative and positive bands respectively. (Author) [es

  20. Study on determination of 90Sr by liquid scintillation spectrometry

    International Nuclear Information System (INIS)

    Zhai Xiufang; Li Weiping; Tian Mei; Zou Ronghu

    2012-01-01

    Both of Liquid scintillation counting and Cerenkov counting can be used to determinate 90 Sr in samples by Liquid scintillation spectrometry. In this work, effects of scintillation vials wit-h different material, Liquid scintillation cocktails, sample volume, Strontium carrier, pH, quenching (chemical quenching and color quenching)are studied, and both counting methods are compared. For Liquid scintillation counting. The results show that the best appropriate volume ratio of sample and liquid scintillation cocktail is 8:12 for OPTIPHASE HISAFE-3 and OPTIPHASE HISAFE-2, stability of solution decreased when sample load exceeds the maximum load for both Liquid scintillation cocktails, and OPTIPHASE HISAFE-3 also show superior performance for high saline solution. The type of scintillation vial haven't clear influence on the MDA of 90 Sr. Chemical quenching and color quenching can decrease the counting efficiency. For Cerenkov counting, the lowest MDA is obtained when polyethylene plastic vial is used and sample volume is 20 ml. Color quenching decreases the counting efficiency, while there isn't chemical quenching for Cerenkov counting. The MDA of 90 Sr is 1.19 and 1.00 Bq/L for Liquid scintillation counting and Cerenkov counting with the optimal labeling condition. (authors)

  1. EPR dose reconstruction for bone-seeking {sup 90}Sr

    Energy Technology Data Exchange (ETDEWEB)

    Ignatiev, E.A.; Romanyukha, A.A. [Institute of Metal Physics, Russian Academy of Sciences, Ekaterinburg (Russian Federation); Lyubashevskii, N.M. [Institute of Plants and Animals Ecology, Russian Academy of Sciences, Ekaterinburg (Russian Federation); Shishkina, E.A. [Urals Research Center for Radiation Medicine, Medgorodok, Chelyabinsk (Russian Federation)

    1999-08-01

    The results of the EPR dose reconstruction in calcified tissues of dog injected with {sup 90}Sr are presented. It has been established that there is no essential difference in the values of doses absorbed in tooth tissues of teeth in symmetric positions in the mouth, whereas a significant difference occurs in the values of absorbed doses in teeth in non-symmetric positions. In the case of {sup 90}Sr internal exposure the dose reconstruction in crown dentine plays an important role. It has been found that its quantity is close to the dose in diaphyseal cortical bone of the femur, dose at the endosteal bone surface and in femural fatty marrow. The fact that these values exceed doses absorbed in tooth enamel points out the predominant contribution of internal exposure. The highest absorbed doses have been observed in metaphyseal trabecular femur bones, tooth alveolar bone walls, and cortical and trabecular vertebra that can be considered as suitable candidates for biomarkers of internal {sup 90}Sr exposure for post-mortal autopsy. The satisfactory correlation has been found between the doses reconstructed in calcified dog tissues and the doses measured by EPR in alanine dosimeters fixed in (or nearby) the sites of autopsy of bones/teeth. The experiments provide support for the view that EPR retrospective dosimetry with calcified tissues for internal exposure is unique in providing useful information on the doses obtained.

  2. Protection against retrovirus pathogenesis by SR protein inhibitors.

    Directory of Open Access Journals (Sweden)

    Anne Keriel

    Full Text Available Indole derivatives compounds (IDC are a new class of splicing inhibitors that have a selective action on exonic splicing enhancers (ESE-dependent activity of individual serine-arginine-rich (SR proteins. Some of these molecules have been shown to compromise assembly of HIV infectious particles in cell cultures by interfering with the activity of the SR protein SF2/ASF and by subsequently suppressing production of splicing-dependent retroviral accessory proteins. For all replication-competent retroviruses, a limiting requirement for infection and pathogenesis is the expression of the envelope glycoprotein which strictly depends on the host splicing machinery. Here, we have evaluated the efficiency of IDC on an animal model of retroviral pathogenesis using a fully replication-competent retrovirus. In this model, all newborn mice infected with a fully replicative murine leukemia virus (MLV develop erythroleukemia within 6 to 8 weeks of age. We tested several IDC for their ability to interfere ex vivo with MLV splicing and virus spreading as well as for their protective effect in vivo. We show here that two of these IDC, IDC13 and IDC78, selectively altered splicing-dependent production of the retroviral envelope gene, thus inhibiting early viral replication in vivo, sufficiently to protect mice from MLV-induced pathogenesis. The apparent specificity and clinical safety observed here for both IDC13 and IDC78 strongly support further assessment of inhibitors of SR protein splicing factors as a new class of antiretroviral therapeutic agents.

  3. Constraining Open-System Processes in the Generation of Basaltic Magma Using 87Sr/86Sr of Individual Minerals and Melt Inclusions, Pisgah Crater, Ca

    Science.gov (United States)

    Ramos, F. C.; Wolff, J. A.

    2002-12-01

    Basaltic magmas have been extensively used to infer the geochemical nature of mantle sources. Studies which make such inferences typically focus on basalts that are characterized by assumed primary magma characteristics such as high MgO contents. Such characteristics are typically used as justification to discount or suggest only a minimal influence of open-system modifications, such as those resulting from crustal assimilation. Often, very little effort is made to more thoroughly eliminate this possibility because it is very difficult to identify and constrain such effects especially if the assimilated crust is mafic in character. Alkali basalts and hawaiities erupted at Pisgah Crater in the Mojave Desert of California result from open-system processes yet still retain high MgO (6-8%) contents. The specific processes responsible for extensive trace element and isotopic variations in these basalts, however, are in dispute. Glazner et al. (1991) suggest that Pisgah Crater trace element and isotopic variations originate from assimilation of mafic crust while Reiners (2002) suggests that such variations result from mixing of mantle-derived garnet peridotite and garnet pyroxenite magmas. Large 87Sr/86Sr variations among and within individual plagioclase, clinopyroxene, amphibole, groundmass, and melt inclusions in olivine attest to the effects of open-system processes and indicate a complex mixing process (i.e., not two-component mixing) that occurred up to the time of eruption (Ramos et al, in prep). 87Sr/86Sr of minerals indicate that early and intermediate erupted lavas retain relatively uncontaminated signatures while the latest erupted lavas reflect much higher 87Sr/86Sr, consistent with contamination at crustal pressures (i.e., within the plagioclase stability field). Major element compositions of melt inclusions hosted in olivine confirm the presence of highly evolved magmas (e.g., MgO: 0.5 to 3%, SiO2: 52-57%) in later erupted lavas. Whole grain olivine

  4. The 87Sr/86Sr aquatic isoscape of the Danube catchment from the source to the mouth as tool for studying fish migrations

    Science.gov (United States)

    Zitek, Andreas; Tchaikovsky, Anastassiya; Irrgeher, Johanna; Waidbacher, Herwig; Prohaska, Thomas

    2014-05-01

    Isoscapes - spatially distributed isotope patterns across landscapes - are increasingly used as important basis for ecological studies. The natural variation of the isotopic abundances in a studied area bears the potential to be used as natural tracer for studying e.g. migrations of animals or prey-predator relations. The 87Sr/86Sr ratio is one important tracer, since it is known to provide a direct relation of biological samples to geologically distinct regions, as Sr isotopes are incorporated into living tissues as a proxy for calcium and taken up from the environment without any significant fractionation. Although until now the focus has been mainly set on terrestrial systems, maps for aquatic systems are increasingly being established. Here we present the first 87Sr/86Sr aquatic isoscape of the Danube catchment, the second largest river catchment in Europe, from near its source starting at river km 2581 in Germany down to its mouth to river km 107 in Romania. The total length of the river Danube is 2780 km draining a catchment area 801 463 km2 (10 % of the European continent). The major purpose of this study was to assess the potential of the 87Sr/86Sr isotope ratio to be used as tool for studying fish migrations at different scales in the entire Danube catchment. Within the Joint Danube Research 3 (JDS 3), the biggest scientific multi-disciplinary river expedition of the World in 2013 aiming at the assessment of the ecological status and degree of human alterations along the river Danube, water samples were taken at 68 pre-defined sites along the course of the river Danube including the major tributaries as a basis to create the so called 'Isoscape of the Danube catchment'. The determination of 87Sr/86Sr isotope ratio in river water was performed by multicollector-sector field-inductively coupled plasma-mass spectrometry (MC-SF-ICP-MS). The JDS 3 data were combined with existing data from prior studies conducted within the Austrian part of the Danube catchment

  5. Identification of reaction compounds in micrometric layers from gothic paintings using combined SR-XRD and SR-FTIR.

    Science.gov (United States)

    Salvadó, Nati; Butí, Salvador; Nicholson, James; Emerich, Hermann; Labrador, Ana; Pradell, Trinitat

    2009-07-15

    Synchrotron radiation X-ray diffraction (micro-SR-XRD) and Fourier transform infrared spectroscopy (micro-SR-FTIR) are used in the non-destructive identification of reaction and aging compounds from micrometric ancient painting layers. The combination of the micrometer size and non-destructive nature of the techniques together with the high resolution and brilliance of the synchrotron radiation has proved to be a procedure most advantageous for the study of reaction, aging and degradation processes. Copper, lead and calcium carboxylates and oxalates are determined in the chromatic, preparation and alteration layers from 15th century egg tempera and oil paintings. Their nature and crystallinity have been assessed. Some hypothesis about the mechanisms of development of both carboxylates and oxalates are presented.

  6. μ+SR Investigation of the Shastry-Sutherland Compound SrCu2(BO3)2

    Science.gov (United States)

    Sassa, Y.; Wang, S.; Sugiyama, J.; Amato, A.; Rønnow, H. M.; Rüegg, C.; Månsson, M.

    In this study we have investigated the low-dimensional correlated spin system SrCu2(BO3)2 using ambient-pressure muon spin rotation/relaxation (μ+SR). The zero-field data are similar to previously published data, but in addition, they give an even clearer sign of the two low-temperature transitions (T1 ≈ 3 and T2 ≈ 7 K), which is fully consistent with inelastic neutron scattering (INS) measurements. Longitudinal field (LF) data clearly show that the copper spins are highly dynamic and a saturation of the low-temperature relaxation rate indicate that these are indeed two-dimensional (2D) quantum spin fluctuations.

  7. Emission of 89/90Sr in the waste air of nuclear power plants with LWR in West Germany

    International Nuclear Information System (INIS)

    Gesewsky, P.; Riedel, H.

    1977-12-01

    In particular the data of Sr-90 concentrations in the gaseous effluent are given for the years 1975 up to 1977 whereas the data for Sr-89 concentrations are given for the year 1977 only. The Sr is radiochemically separated after dissolution of the aerosol filters and Sr-89 and Sr-90 are measured by two countings on a low-level β-counter. (Single separation method). From this measurements the following average emissionrates, based on a power generation of 1 GWa were calculated: BWR's: 3,0 .(period on line) 10 -4 Ci Sr-89, 2,0 .(period on line) 10 -5 Ci Sr-90; PWR's: -6 Ci Sr-90, -5 Ci-Sr-89. In comparison to the emission of long-lived radioactive aerosols with the airborne effluent of light water cooled power reactors the Sr-90 contribution is clearly below 1% usually assumed in safety calculations. (orig./HP) [de

  8. Preparation of highly stable zeolite-alginate foam composite for strontium(90Sr) removal from seawater and evaluation of Sr adsorption performance.

    Science.gov (United States)

    Hong, Hye-Jin; Kim, Byoung-Gyu; Ryu, Jungho; Park, In-Su; Chung, Kang-Sup; Lee, Sang Moon; Lee, Jin-Bae; Jeong, Hyeon Su; Kim, Hyunchul; Ryu, Taegong

    2018-01-01

    Alginate bead is a promising strontium (Sr) adsorbent in seawater, but highly concentrated Na ions caused over-swelling and damaged the hydrogel bead. To improve the mechanical stability of alginate bead, flexible foam-type zeolite-alginate composite was synthesized and Sr adsorption performance was evaluated in seawater; 1-10% zeolite immobilized alginate foams were prepared by freeze-dry technique. Immobilization of zeolite into alginate foam converted macro-pores to meso-pores which lead to more compact structure. It resulted in less swollen composite in seawater medium and exhibited highly improved mechanical stability compared with alginate bead. Besides, Sr adsorption efficiency and selectivity were enhanced by immobilization of zeolite in alginate foam due to the increase of Sr binding sites (zeolite). In particular, Sr selectivity against Na was highly improved. The 10% zeolite-alginate foam exhibited a higher log K d of 3.3, while the pure alginate foam exhibited 2.7 in the presence of 0.1 M Na. Finally, in the real seawater, the 10% zeolite-alginate foam exhibited 1.5 times higher Sr adsorption efficiency than the pure alginate foam. This result reveals that zeolite-alginate foam composite is appropriate material for Sr removal in seawater due to its swelling resistance as well as improved Sr adsorption performance in complex media. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. 87Sr/86Sr and 18O/16O ratios, interstitial water chemistry and diagenesis in deep-sea carbonate sediments of the Ontong Java Plateau

    International Nuclear Information System (INIS)

    Elderfield, H.; Oldfield, R.K.; Hawkesworth, C.J.

    1982-01-01

    Interstitial waters and sediments from DSDP sites 288 and 289 contain information on the chemistry and diagenesis of carbonate in deep-sea sediments and on the role of volcanic matter alteration processes. Sr/Ca ratios are species dependent in unaltered foraminifera from site 289 and atom ratios exceed those predicted by distribution coefficient data. During diagenesis Sr/Ca ratios of carbonates decrease and reach the theoretical distribution at a depth which is identical to the depth of Sr isotopic equilibration, where 87 Sr/ 86 Sr ratios of interstitial waters and carbonates converge. Mg/Ca ratios in the carbonates do not increase with depth as found in some other DSDP sites, possibly because of diagenetic re-equilibration with interstitial waters showing decreasing Mg 2+ /Ca 2+ ratios with depth due to Ca input and Mg removal by alteration of volcanic matter. Interstitial 18 O/ 16 O ratios increase with depth at site 289 to delta 18 O = 0.67 per thousand (SMOW), reflecting carbonate recrystallization at elevated temperatures, the first recorded evidence of this effect in interstitial waters. Interstitial Sr 2+ concentrations reach high levels, up to 1 mM, chiefly because of carbonate recrystallization. However, 87 Sr/ 86 Sr ratios decrease from 0.7092 to less than 0.7078, lower than for contemporaneous sea water, showing that there is a volcanic input of strontium at depth. (author)

  10. SSTs from Fossil Corals using Sr-U Thermometry

    Science.gov (United States)

    Cohen, A. L.; Alpert, A.; Soucy, A.; DeCarlo, T. M.; Vasquez-Bedoya, L. F.; Blanchon, P.; Oppo, D.; Gaetani, G. A.

    2017-12-01

    Earth's climate varies naturally on decadal through millennial timescales. Resolving and attributing the anthropogenic influence on climate therefore, requires accurate, continuous records that exceed the duration of the short observational dataset. Sea surface temperatures (SSTs) of warm tropical regions are especially important because the tropics are regions of deep atmospheric convection that redistribute heat and moisture. The skeletons of long-lived corals are valuable archives of tropical ocean temperature, yet the pre-instrumental SST evolution of the global tropical oceans remains poorly constrained. One reason is the limited lifespan of individual coral colonies, which seldom exceeds 150-200 years. Thus, extending SST records well beyond the observational period requires use of well-dated sub-fossil material but the current coral-based temperature proxy, Sr/Ca, is not well-suited for application to non-living material. The sensitivity of the Sr/Ca-SST relationship can vary from coral to coral, limiting the accuracy with which absolute temperature and trends can be interpreted from non-living corals. To overcome this constraint, we developed a new thermometer, Sr-U, based on a robust understanding of the processes responsible for colony-to-colony variability. Our Sr-U SST calibration is derived from three coral species representing two Atlantic and one Pacific site, validated against the instrumental record of SST and spanning a temperature range of 24.5 through 28.5 °C. We applied Sr-U to U-series dated fossil corals that grew on tropical Atlantic reefs during the Little Ice Age (1450-1650 AD) and Last Interglacial (122 000 yr BP). Our results show that SSTs in the region fluctuated within 1°C of modern values, with much of the late LIA slightly cooler and the LIG slightly warmer than late 20th century SSTs. Each continuous coral-based record spans multiple decades, enabling us to identify multi-decadal AMO-like variability as a persistent

  11. Comparing Pt/SrTiO3 to Rh/SrTiO3 for hydrogen photocatalytic production from ethanol

    KAUST Repository

    Wahab, A. K.

    2013-08-13

    Photocatalytic hydrogen production from ethanol as an example of biofuel is studied over 0.5 wt% Rh/SrTiO3 and 0.5 wt% Pt/SrTiO3 perovskite materials. The rate of hydrogen production, rH2, over Pt/SrTiO3 is found to be far higher than that observed over Rh/SrTiO3 (4 × 10−6 mol of H2 g catal. −1 min−1 (1.1 × 10−6 mol of H2 m catal. −2 min−1) compared to 0.7 × 10−6 mol of H2 g catal. −1 min−1 (5.5 × 10−8 mol of H2 m catal. −2 min−1), respectively, under UV excitation with a flux equivalent to that from the sun light (ca. 1 mW cm−2). Analyses of the XPS Rh3d and XPS Pt4f indicate that Rh is mainly present in its ionic form (Rh3+) while Pt is mainly present in its metallic form (Pt0). A fraction of the non-metallic state of Rh in the catalyst persisted even after argon ion sputtering. The tendency of Rh to be oxidized compared to Pt might be the reason behind the lower activity of the former compared to the later. On the contrary, a larger amount of methane are formed on the Rh containing catalyst compared to that observed on the Pt containing catalyst due to the capacity of Rh to break the carbon–carbon bond of the organic compound.

  12. Reduction and technical simplification of testing protocol for walking based on repeatability analyses: An Interreg IVa pilot study

    Directory of Open Access Journals (Sweden)

    Nejc Sarabon

    2010-12-01

    Full Text Available The aim of this study was to define the most appropriate gait measurement protocols to be used in our future studies in the Mobility in Ageing project. A group of young healthy volunteers took part in the study. Each subject carried out a 10-metre walking test at five different speeds (preferred, very slow, very fast, slow, and fast. Each walking speed was repeated three times, making a total of 15 trials which were carried out in a random order. Each trial was simultaneously analysed by three observers using three different technical approaches: a stop watch, photo cells and electronic kinematic dress. In analysing the repeatability of the trials, the results showed that of the five self-selected walking speeds, three of them (preferred, very fast, and very slow had a significantly higher repeatability of the average walking velocity, step length and cadence than the other two speeds. Additionally, the data showed that one of the three technical methods for gait assessment has better metric characteristics than the other two. In conclusion, based on repeatability, technical and organizational simplification, this study helped us to successfully define a simple and reliable walking test to be used in the main study of the project.

  13. Encapsulation of Cs/Sr contaminated clinoptilolite in geopolymers produced from metakaolin

    Energy Technology Data Exchange (ETDEWEB)

    Kuenzel, C., E-mail: c.kuenzel08@imperial.ac.uk [Department of Civil and Environmental Engineering, Imperial College London, South Kensington Campus, London SW72AZ (United Kingdom); Centre for Advanced Structural Ceramics, Department of Materials, Imperial College London, South Kensington Campus, London SW72AZ (United Kingdom); Cisneros, J.F. [Department of Civil and Environmental Engineering, Imperial College London, South Kensington Campus, London SW72AZ (United Kingdom); Neville, T.P. [Centre for CO_2 Technology, Department of Chemical Engineering, University College London, Gower Street, London WC1E6JE (United Kingdom); Vandeperre, L.J. [Centre for Advanced Structural Ceramics, Department of Materials, Imperial College London, South Kensington Campus, London SW72AZ (United Kingdom); Simons, S.J.R.; Bensted, J. [Centre for CO_2 Technology, Department of Chemical Engineering, University College London, Gower Street, London WC1E6JE (United Kingdom); Cheeseman, C.R. [Department of Civil and Environmental Engineering, Imperial College London, South Kensington Campus, London SW72AZ (United Kingdom)

    2015-11-15

    The encapsulation of caesium (Cs) and strontium (Sr) contaminated clinoptilolite in Na and K based metakaolin geopolymers is reported. When Cs or Sr loaded clinoptilolite is mixed with a metakaolin geopolymer paste, the high pH of the activating solution and the high concentration of ions in solution cause ion exchange reactions and dissolution of clinoptilolite with release of Cs and Sr into the geopolymer matrix. The leaching of Cs and Sr from metakaolin-based geopolymer has therefore been investigated. It was found that Na-based geopolymers reduce leaching of Cs compared to K-based geopolymers and the results are in agreement with the hard and soft acids and bases (HSAB) theory. Cs ions are weak Lewis acids and aluminates are a weak Lewis base. During the formation of the geopolymer matrix Cs ions are preferentially bound to aluminate phases and replace Na in the geopolymer structure. Sr uptake by Na-geopolymers is limited to 0.4 mol Sr per mole of Al and any additional Sr is immobilised by the high pH which causes precipitation of Sr as low solubility hydroxide and carbonate phases. There was no evidence of any other phases being formed when Sr or Cs are added to metakaolin geopolymers. - Highlights: • Leaching. • Encapsulation of Cs and Sr. • Nuclear waste. • Clinoptilolite.

  14. Subsolidus Phase Relations of the CoOx-CuO-SrO System  

    DEFF Research Database (Denmark)

    Grivel, Jean-Claude

    2017-01-01

    The subsolidus phase relations of the CoOx-CuO-SrO system were investigated in air. The samples were equilibrated at 900 °C. The pseudo-ternary section contains three stoichiometric binary oxide phases (Sr2CuO3, SrCuO2 and Sr14Cu24O41−δ) and a binary oxide solid solution: Sr6+xCo5O15+δ (0 ≤ x ≤ 0.......36). Two binary phases extend into the ternary system forming solid solutions, i.e., Sr14Cu24−xCoxO41−δ (0 ≤ x ≤ 5) and Sr6+xCo5−yCuyO15+δ (0 ≤ x ≤ 0.36, 0 ≤ y ≤ 1.0). The Sr6+xCo5O15+δ solid solution was found to undergo a phase separation into a mixture of Sr6Co5O15−δ and Sr14Co11O33 upon annealing...

  15. Positron annihilation study of Sr Doping in La{sub 2-x}Sr{sub x}CuO{sub 4}

    Energy Technology Data Exchange (ETDEWEB)

    Sterne, P.A. [Lawrence Livermore National Lab., CA (United States)]|[California Univ., Davis, CA (United States); Howell, R.H.; Fluss, M.J. [Lawrence Livermore National Lab., CA (United States); Kaiser, J.H. [Texas Univ., Arlington, TX (United States); Kitazawa, K. [Tokyo Univ. (Japan); Kojima, H. [Yamanashi Univ., Kofu (Japan)

    1993-04-22

    We present a combined experimental and threshold study of effects of Sr doping on electronic structure of La{sub 2-x}Sr{sub x}CuO{sub 4}. Electron-positron momentum distributions have been measured to high statistical precision (> 4 {times} 10{sup 8} counts) at room temperature for samples with Sr concentrations of x = 0.0, 0.1, 0.13 and 0.2. Analysis of all four spectra reveal strong features due to electron-positron wavefunction overlap, in quantitative agreement with theoretical calculations. The Sr doped samples show discontinuities consistent with presence of a Fermi surface. The form and position of these features are in general agreement with the predictions of band theory. Correspondence between theory and experiment, as well as some differences, are revealed by a detailed study of the changes in electron-position momentum density with increasing Sr doping.

  16. Strontium (Sr) elicits odontogenic differentiation of human dental pulp stem cells (hDPSCs): A therapeutic role for Sr in dentine repair?

    Science.gov (United States)

    Huang, Mei; Hill, Robert G; Rawlinson, Simon C F

    2016-07-01

    Strontium (Sr) forms a significant component of dental restorative materials and although it is widely used in toothpastes, the biological effects of Sr on the dentine-pulp complex have not been investigated. In this first study, we characterise the Sr elicited effects on human dental pulp stem cells (hDPSC) in vitro using exogenously Sr added to culture medium, and bioavailable Sr derived from a novel bioactive glass (BG). The related mechanisms were also investigated. Our results indicate that low dose Sr (between 0.1 and 2.5mM) induces proliferation and alkaline phosphatase (ALP) activity of hDPSCs, but has no effect on colony formation or cell migration. Sr at specific concentrations (1 and 2.5mM) stimulated collagen formation and mineralisation of the hDPSC generated matrix. In addition, qRT-PCR, Western blotting and immunocytochemistry revealed that Sr regulates gene expression and the protein secretion of the odontogenic markers: dentine sialophosphoprotein (DSPP) and dentine matrix protein 1 (DMP-1) and protein localisation (DSPP was localised to the Golgi, while no apparent changes occur in DMP-1 distribution which remains in both cytosol and the nucleus). Additionally, the calcium sensing receptor (CaSR) and downstream pathway MAPK/ERK signalling pathway in hDPSCs were activated by Sr. Bioavailable Sr from the BG revealed novel biological insights of regulating metabolic and ALP activities in hDPSCs. Taken together, these results suggest that Sr at specific doses significantly influences proliferation, odontogenic differentiation and mineralisation of hDPSCs in vitro via the CaSR using a pathway with similarities to osteoblast differentiation. These are the first such studies and indicate that Sr treatment of hDPSCs could be a promising therapeutic agent in dental applications. In conclusion, we propose that Sr from a substituted BG could be used more effectively in biomaterials designed for dental applications. Despite the fact that strontium (Sr) is

  17. Toward the establishment of standardized in vitro tests for lipid-based formulations. 2. The effect of bile salt concentration and drug loading on the performance of type I, II, IIIA, IIIB, and IV formulations during in vitro digestion.

    Science.gov (United States)

    Williams, Hywel D; Anby, Mette U; Sassene, Philip; Kleberg, Karen; Bakala-N'Goma, Jean-Claude; Calderone, Marilyn; Jannin, Vincent; Igonin, Annabel; Partheil, Anette; Marchaud, Delphine; Jule, Eduardo; Vertommen, Jan; Maio, Mario; Blundell, Ross; Benameur, Hassan; Carrière, Frédéric; Müllertz, Anette; Pouton, Colin W; Porter, Christopher J H

    2012-11-05

    The LFCS Consortium was established to develop standardized in vitro tests for lipid-based formulations (LBFs) and to examine the utility of these tests to probe the fundamental mechanisms that underlie LBF performance. In this publication, the impact of bile salt (sodium taurodeoxycholate, NaTDC) concentration and drug loading on the ability of a range of representative LBFs to generate and sustain drug solubilization and supersaturation during in vitro digestion testing has been explored and a common driver of the potential for drug precipitation identified. Danazol was used as a model poorly water-soluble drug throughout. In general, increasing NaTDC concentrations increased the digestion of the most lipophilic LBFs and promoted lipid (and drug) trafficking from poorly dispersed oil phases to the aqueous colloidal phase (AP(DIGEST)). High NaTDC concentrations showed some capacity to reduce drug precipitation, although, at NaTDC concentrations ≥3 mM, NaTDC effects on either digestion or drug solubilization were modest. In contrast, increasing drug load had a marked impact on drug solubilization. For LBFs containing long-chain lipids, drug precipitation was limited even at drug loads approaching saturation in the formulation and concentrations of solubilized drug in AP(DIGEST) increased with increased drug load. For LBFs containing medium-chain lipids, however, significant precipitation was evident, especially at higher drug loads. Across all formulations a remarkably consistent trend emerged such that the likelihood of precipitation was almost entirely dependent on the maximum supersaturation ratio (SR(M)) attained on initiation of digestion. SR(M) defines the supersaturation "pressure" in the system and is calculated from the maximum attainable concentration in the AP(DIGEST) (assuming zero precipitation), divided by the solubility of the drug in the colloidal phases formed post digestion. For LBFs where phase separation of oil phases did not occur, a

  18. Comparative study of potentially J{sub eff} = 0 ground state iridium(V) in SrLaNiIrO{sub 6}, SrLaMgIrO{sub 6}, and SrLaZnIrO{sub 6}

    Energy Technology Data Exchange (ETDEWEB)

    Wolff, Klaus K.; Agrestini, Stefano; Tjeng, Liu Hao [Max Planck Institute for Chemical Physics of Solids, Dresden (Germany); Tanaka, Arata [Department of Quantum Matter, AdSM, Hiroshima University, Higashi-Hiroshima (Japan); Jansen, Martin [Max Planck Institute for Chemical Physics of Solids, Dresden (Germany); Max Planck Institute for Solid State Research, Stuttgart (Germany)

    2017-12-13

    A series of polycrystalline double perovskites SrLaBIrO{sub 6} (B = Ni, Mg, Zn) containing Ir{sup 5+} (5d{sup 4}) was synthesized by solid state reactions, and structural, magnetic and electronic properties were investigated. The isotypic fully ordered double perovskites crystallize in space group P2{sub 1}/n and show semiconducting behavior with estimated bandgaps of approximately 0.2 eV for SrLaNiIrO{sub 6} and SrLaZnIrO{sub 6}, and 0.4 eV for SrLaMgIrO{sub 6}. SrLaNiIrO{sub 6} is an antiferromagnet with a Neel temperature of 74 K (μ{sub eff} = 3.3 μ{sub B}, θ{sub W} = -90 K), whereas SrLaMgIrO{sub 6} and SrLaZnIrO{sub 6} are weakly paramagnetic. All title compounds exhibit a temperature-independent contribution to the measured magnetic susceptibility, which supports the notion for a van-Vleck-type response originating from the Ir{sup 5+} (5d{sup 4}, J{sub eff} = 0) ions. (copyright 2017 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  19. Binding of Sr from milk by solid phase extraction with cryptand C222 sorbed on silica gel, cation exchange, chelating or adsorbent resins for simplified 90Sr analysis

    International Nuclear Information System (INIS)

    Tait, David; Wiechen, Arnold; Haase, Gerhard

    1995-01-01

    Several commercially available resins have been found to bind the bicyclic polyether cryptand C222 from aqueous acetonitrile solutions. The presence of C222 on some of these resins strongly improved their affinity for Sr, so that relatively small amounts of such resins sorbed Sr from milk. The resins investigated were silica gel, polyacrylic acid crosslinked with divinylbenzene (DVB), polystyrene crosslinked with divinylbenzene (PS-DVB) and PS-DVB containing sulphonate, aminomethylphosphonate, iminodiacetate and mercapto groups. The resins for which binding of C222 resulted in the largest improvement in Sr sorption from milk were PS-DVB containing mercapto groups (Chelite S) and silica gel (Si 60). Thus, 2 ml wet volume of either Chelite S containing 133 μmol of C222, or silica gel Si-60 containing 143 μmol of C222 sorbed 90 and 48%, respectively, of the Sr from 100-ml milk samples. As the sorption of Sr from milk by these systems is relatively slow, contact times of 24-36 h are required to attain these results. The Chelite S-C222 system separates Sr effectively from Cs and Ca. Under the conditions described here some 6% of the natural 40 K in milk sorbs with Sr to the resin. Ba behaves similarly to Sr. 90 Sr/ 90 Y sorbed on the silica gel Si-60-C222 system can be measured directly and efficiently by liquid scintillation counting. If adequate specificity can be attained this system might provide a very simple method of determining 90 Sr in milk

  20. FLOOD 1. Final Report

    OpenAIRE

    Adams, Brian; Bloomfield, John; Gallagher, Alexander; Jackson, Christopher; Rutter, Helen; Williams, Ann

    2008-01-01

    The FLOOD 1 project was carried out by the French Geological Survey (BRGM), the University of Brighton and the British Geological Survey from April 2004 to June 2008 inclusive. It was carried out under the INTERREG IIIA initiative of the European Union which provided 50% of the funding, the remainder coming from the three project partners and a number of industrial partners who also formed the Project Advisory Group. The project was set up to develop appropriate early warning s...

  1. Synthesis, structure and fluorescence properties of a novel 3D Sr(II) coordination polymer

    Science.gov (United States)

    Tan, Yu-Hui; Xu, Qing; Gu, Zhi-Feng; Gao, Ji-Xing; Wang, Bin; Liu, Yi; Yang, Chang-Shan; Tang, Yun-Zhi

    2016-09-01

    Solvothermal reaction of 2,2‧-bipyridine-5,5‧-dicarboxylic acid (H2bpdc) and SrCl2 affords a novel coordination polymer [Sr(Hbpdc)2]n1. X-ray structure determination shows that 1 exhibits a novel three-dimensional network. The unique Sr II cation sits on a two-fold axis and coordinated by four O-atom donors from four Hbptc- ligands and four N-atom donors from two Hbptc- ligands in distorted dodecahedral geometry. In 1 each Sr II cation connects to six different Hbptc- ligands and each Hbptc- ligand bridges three different Sr II cations which results in the formation of a three-dimensional polymeric structure. Corresponding to the free ligand, the fluorescent emission of complex 1 display remarkable "Einstain" shifts, which may be attributed to the coordination interaction of Sr atoms, thus reduce the rigidity of pyridyl rings.

  2. Long lasting fish contamination with 90Sr of Ignalina NPP water cooling basin

    International Nuclear Information System (INIS)

    Dusauskiene-Duz, R.; Gudeliene, I.

    2003-01-01

    Between the nourishment chains in hydro ecosystem the main role have chain water-fish-man, because amount of 90 Sr in fish muscle is limited. 90 Sr accumulation and distribution between the fish organs and tissues was studied. It was found that the main way of 90 Sr enter to the Ignalina NPP water cooling basin fish is adsorption processes which is more active than that of absorption. Established regularities of distribution between the fish organs and tissues, which depends on the fish nourishment type and their species. We determined that 90 Sr activity in fish muscles increase from spring to autumn: in Rutilus rutilus - 8, Abramis brama - 6, Perca fluviatilis - 2,7 and Esox lucius - 22,3 times. We determined that 90 Sr activity in fish muscles is 24 times lower than permissible' standard. It was determined that 90 Sr activity in fish gonads is 2 times higher than that in muscles and depends on fish species. (author)

  3. Electrochemical characterization and redox behavior of Nb-doped SrTiO3

    DEFF Research Database (Denmark)

    Blennow Tullmar, Peter; Kammer Hansen, Kent; Wallenberg, L. Reine

    2009-01-01

    Sr-vacancy compensated Nb-doped SrTiO3 with the nominal composition Sr0.94Ti0.9Nb0.1O3 has been evaluated as a solid oxide fuel cell (SOFC) anode material in terms of redox stability and electrochemical properties. Sr0.94Ti0.9Nb0.1O3 has been synthesized with a recently developed modified glycine......-nitrate process. The phase purity and redox behavior have been analyzed with XRD and TGA. The electrochemical properties of Sr0.94Ti0.9Nb0.1O3 and a composite electrode of Sr0.94Ti0.9Nb0.1O3/YSZ have been investigated by electrochemical impedance spectroscopy (EIS) on cone shaped electrodes and on electrodes...

  4. Determination of 90Sr by liquid scintillation spectrometry in samples of contaminated water

    International Nuclear Information System (INIS)

    Ometakova, J.; Dulanska, S.

    2009-01-01

    On a model sample we optimized conditions of SPE separation of 90 Sr on Empore Sr Rad Disk in term of use eluent reagent and its appropriate concentration. Also the possibility of multiple use of both sorbents Empore Sr Rad Disk and AnaLig Sr-01 was confirmed. Not even after 8 separations radiochemical yield fall below 87%. For separation of 90 Sr from real sample of percolating water of controlled area of Bohunice NPP three commercially available products were used: 3M Empore Strontium Rad Disk, sorbents AnaLig (with different grain size) and Sr-Resin. The aim of this work was to compare the selected products in term of strontium extracts, the time demandingness and the possibility of multiple use of sorbents. For separation of strontium were also used two classical methods, namely liquid extraction with tributyl phosphate and carbonate precipitation due to the exclusion of interferents. (author)

  5. Core level photoemission spectroscopy and chemical bonding in Sr2Ta2O7

    DEFF Research Database (Denmark)

    Atuchin, V. V.; Grivel, Jean-Claude; Zhang, Z. M.

    2009-01-01

    Electronic parameters of constituent element core levels of strontium pyrotantalate (Sr2Ta2O7) were measured with X-ray photoelectron spectroscopy (XPS). The Sr2Ta2O7 powder sample was synthesized using standard solid state method. The valence electron transfer on the formation of the Sr-O and Ta......-O bonds was characterized by the binding energy differences between the O 1s and cation core levels, Delta(O-Sr) = BE(O 1s) - BE(Sr 3d(5/2)) and Delta(O-Ta) = BE(O 1s) - BE(Ta 4f(7/2)). The chemical bonding effects were considered on the basis of our XPS results for Sr2Ta2O7 and earlier published...

  6. Knockdown expression and hepatic deficiency reveal anatheroprotective role for SR-BI in liver and peripheral tissues

    Energy Technology Data Exchange (ETDEWEB)

    Huby, Thierry; Doucet, Chantal; Dachet, Christiane; Ouzilleau,Betty; Ueda, Yukihiko; Afzal, Veena; Rubin, Edward; Chapman, M. John; Lesnik, Philippe

    2006-07-18

    Scavenger receptor SR-BI has been implicated inHDL-dependent atheroprotective mechanisms. We report the generation of anSR-BI conditional knockout mouse model in which SR-BI gene targeting byloxP site insertion produced a hypomorphic allele (hypomSR-BI).Attenuated SR-BI expression in hypomSR-BI mice resulted in 2-foldelevation in plasma total cholesterol (TC) levels. Cre-mediated SR-BIgene inactivation of the hypomorphic SR-BI allele in hepatocytes(hypomSR-BI-KOliver) was associated with high plasma TC concentrations,increased plasma free cholesterol/TC (FC/TC) ratio, and alipoprotein-cholesterol profile typical of SR-BI-/- mice. Plasma TClevels were increased 2-fold in hypomSR-BI and control mice fed anatherogenic diet, whereas hypomSR-BI-KOliver and SR-BI-/- mice developedsevere hypercholesterolemia due to accumulation of FC-rich, VLDL-sizedparticles. Atherosclerosis in hypomSR-BI mice was enhanced (2.5-fold)compared with that in controls, but to a much lower degree than inhypomSR-BI-KOliver (32-fold) and SR-BI-/- (48-fold) mice. The lattermodels did not differ in either plasma lipid levels or in the capacity ofVLDL-sized lipoproteins to induce macrophage cholesterol loading.However, reduced atherosclerosis in hypomSR-BI-KOliver mice wasassociated with decreased lesional macrophage content as compared withthat in SR-BI-/- mice. These data imply that, in addition to its majoratheroprotective role in liver, SR-BI may exert an antiatherogenic rolein extrahepatic tissues.

  7. Eu and Sr2CeO4 : Eu phosphors suitable for near ultraviolet excitation

    Indian Academy of Sciences (India)

    Administrator

    et al 2009). It absorbs ultraviolet radiation and emits white light, when activated by Eu2+ ions. It is anticipated that the dual behaviour of Sr2CeO4 : Eu3+ and Sr2CeO4 : Eu2+ phosphors ... in stoichiometric proportions (Sr : Ce is 2 : 1) and Eu2O3. (National ..... Zhang C X, Jiang W J and Yang X J 2009 J. Alloys Compd. 474.

  8. Intestinal SR-BI does not impact cholesterol absorption or transintestinal cholesterol efflux in mice.

    Science.gov (United States)

    Bura, Kanwardeep S; Lord, Caleb; Marshall, Stephanie; McDaniel, Allison; Thomas, Gwyn; Warrier, Manya; Zhang, Jun; Davis, Matthew A; Sawyer, Janet K; Shah, Ramesh; Wilson, Martha D; Dikkers, Arne; Tietge, Uwe J F; Collet, Xavier; Rudel, Lawrence L; Temel, Ryan E; Brown, J Mark

    2013-06-01

    Reverse cholesterol transport (RCT) can proceed through the classic hepatobiliary route or through the nonbiliary transintestinal cholesterol efflux (TICE) pathway. Scavenger receptor class B type I (SR-BI) plays a critical role in the classic hepatobiliary route of RCT. However, the role of SR-BI in TICE has not been studied. To examine the role of intestinal SR-BI in TICE, sterol balance was measured in control mice and mice transgenically overexpressing SR-BI in the proximal small intestine (SR-BI(hApoCIII-ApoAIV-Tg)). SR-BI(hApoCIII-ApoAIV-Tg) mice had significantly lower plasma cholesterol levels compared with wild-type controls, yet SR-BI(hApoCIII-ApoAIV-Tg) mice had normal fractional cholesterol absorption and fecal neutral sterol excretion. Both in the absence or presence of ezetimibe, intestinal SR-BI overexpression had no impact on the amount of cholesterol excreted in the feces. To specifically study effects of intestinal SR-BI on TICE we crossed SR-BI(hApoCIII-ApoAIV-Tg) mice into a mouse model that preferentially utilized the TICE pathway for RCT (Niemann-Pick C1-like 1 liver transgenic), and likewise found no alterations in cholesterol absorption or fecal sterol excretion. Finally, mice lacking SR-BI in all tissues also exhibited normal cholesterol absorption and fecal cholesterol disposal. Collectively, these results suggest that SR-BI is not rate limiting for intestinal cholesterol absorption or for fecal neutral sterol loss through the TICE pathway.

  9. Antlers of Cervus elaphus as biomonitors of {sup 90}Sr in the environment

    Energy Technology Data Exchange (ETDEWEB)

    Baeza, A.; Vallejo, I. [LARUEX, Dpt. Applied Physics, Faculty of Veterinary Sciences, University of Extremadura, Avda, 10003 Caceres (Spain); Guillen, J., E-mail: fguillen@unex.e [LARUEX, Dpt. Applied Physics, Faculty of Veterinary Sciences, University of Extremadura, Avda, 10003 Caceres (Spain); Salas, A.; Corbacho, J.A. [LARUEX, Dpt. Applied Physics, Faculty of Veterinary Sciences, University of Extremadura, Avda, 10003 Caceres (Spain)

    2011-03-15

    Adequate radioprotection of the environment requires the identification of biomonitors sensitive to the variation of its radionuclide content. Due to the chemical similarities between calcium and strontium, calcified tissues of mammals are considered to be good {sup 90}Sr biomonitors. This work considered Cervus elaphus antlers which, being shed annually, can give information about the importance of radiostrontium contamination in an ecosystem in the time period required for the growth of the antler. The samples were collected at various points of W and SW Spain. The mean value of their {sup 90}Sr content was (70 {+-} 43 (S.D.)) Bq/kg d.w., range (16-218) Bq/kg d.w., and the radionuclide was evenly distributed in the different parts of the antler. There was a good correlation between the antlers' {sup 90}Sr content and the {sup 90}Sr deposited in the soil. The antlers' content of {sup 226}Ra (from the natural uranium series) and the contents of some stable elements (Ca, Mg, Sr, and K) were also determined. The values for these stable elements were practically constant in the analyzed samples, and the concentrations measured decreased in the following order: Ca > Mg > K > Sr > {sup 90}Sr > {sup 226}Ra - Research highlights: {yields} There was a good correlation between the antlers' {sup 90}Sr content and the {sup 90}Sr deposited in the soil. {yields} The content of stable elements (Ca, Mg, Sr, K) in the analyzed antlers were practically constant. {yields} The concentrations measured decreased in the following order: Ca > Mg > K > Sr >{sup 90}Sr >{sup 226}Ra.

  10. Ca and Sr isotope records support ocean acidification during end-Permian mass extinction

    Science.gov (United States)

    Wang, J.; Jacobson, A. D.; Zhang, H.; Ramezani, J.; Sageman, B. B.; Hurtgen, M.; Bowring, S. A.; Shen, S.

    2017-12-01

    The end-Permian mass extinction represents the most devastating loss of biodiversity during the Phanerozoic. A negative carbon isotope (δ13C) excursion that accompanies the event suggests a significant perturbation to the global carbon cycle, likely induced by CO2 emissions during eruption of the Siberian Traps large igneous province. The carbon cycle is linked with the Ca and Sr cycles through chemical weathering and carbonate precipitation. Therefore, analyses of Ca (δ44/40Ca), radiogenic Sr (87Sr/86Sr), and stable Sr (δ88/86Sr) isotope abundance variations in marine carbonate rocks spanning the Permian-Triassic Boundary (PTB) can reveal key information about biogeochemical changes that occurred during this time. We report δ44/40Ca, 87Sr/86Sr, and δ88/86Sr records analyzed by TIMS for the Meishan and Dajiang sections in China. δ44/40Ca values exhibit similar patterns in both sections. The values remain unchanged across the extinction event layer (EXT) and then decrease by 0.20‰ before increasing by 0.20‰ to 0.40‰ around the PTB. In the Meishan section, 87Sr/86Sr ratios increase after the EXT and return to pre-excursion levels by the PTB. Simultaneously, δ88/86Sr values decrease by 0.12‰ across the EXT and increase by 0.08‰ by the PTB. The patterns of our data support the hypothesis that elevated atmospheric CO2 levels enhanced chemical weathering inputs and might have caused transient ocean acidification, with an "alkalinity overshoot" and increased carbonate deposition occurring after the extinction. Additional measurements and model calculations are underway to help refine and improve these preliminary interpretations.

  11. The Ca(PO3)2-Sr(PO3)2 system

    International Nuclear Information System (INIS)

    Bukhalova, G.A.; Tokman, I.A.

    1977-01-01

    Phase diagram of the system Ca(PO 3 ) 2 -Sr(PO 3 ) 2 has been studied and plotted with the aid of differential thermal, visual polythermal, X-ray analysis, and infrared spectroscopy. Continuous solid solutions are formed in the system with a minimum at 968 deg C and 25 mol.% of Sr(PO 3 ) 2 . Solid solutions decompose with the formation of about 30 mol.% of Sr(PO 3 ) 2

  12. Acid indium strontium phosphate SrIn2[PO3(OH)]4: synthesis and crystal structure

    International Nuclear Information System (INIS)

    Rusakov, D.A.; Bobylev, A.P.; Komissarova, L.N.; Filaretov, A.A.; Danilov, V.P.

    2007-01-01

    Acid indium-strontium phosphate SrIn 2 [PO 3 (OH)] 4 is synthesized and characterized. Crystal structure and lattice parameters ate determined. In atoms in SrIn 2 [PO 3 (OH)] 4 structure are in distorted InO 6 octahedrons and form with PO 3 (OH) tetrahedrons mixed paraskeleton {In 2 [PO 3 (OH)] 4 } 3∞ 2- with emptinesses occupied by big Sr 2+ cations. The compound is thermally stable up to 400 Deg C [ru

  13. Stable Strontium Isotope (δ88/86Sr) Fractionation in the Marine Realm: A Pilot Study

    OpenAIRE

    Krabbenhöft, André

    2011-01-01

    The determination of the isotopic composition of natural substances is an important field of research within isotope geochemistry. Especially the investigation of the alkaline earth element strontium (Sr) plays an important role in geological and geochemical research. In order to quantify the degree of natural stable Sr isotope fractionation a double spike technique was developed in the frame of this study. This technique allows the precise determination of natural Sr isotope frac...

  14. Anorthite glass: a potential host matrix for 90Sr pencil

    International Nuclear Information System (INIS)

    Sengupta, Pranesh; Dey, G.K.; Fanara, Sara; Chakraborty, Sumit; Mishra, R.K.; Kaushik, C.P.

    2011-01-01

    With rising global concerns over health hazards, environmental pollution and possible malicious applications of radioactive materials, there is an increasing consciousness among public and Governmental agencies for its better control, accounting and security. Investigations carried out by International Atomic Energy Agency and other monitoring bodies reveal that among various radioactive materials, the easily dispersible ones are high activity sealed sources (generally called radioactive pencils) used for various peaceful applications. Ideally, these sealed sources should be safely secured within specialized facilities, but in practice, it is not always done. Hence, there is a need to take an extra precautionary measure to ensure that the matrices currently used for hosting the radionuclides within sealed sources are durable enough under harsh service conditions and situations arising due to possible mishaps (accidents, misplaced, stolen etc). Among the variety of useful radionuclides, 90 Sr is one which is regularly used to (i) combat bone cancer, (ii) destroy unwanted tissue on the surface of eye/skin, (iii) light up/provide energy to remotely accessible areas etc. However, due to its (i) toxicity, (ii) mobility, (iii) easy incorporation within human body, (iv) considerable half-life (∼ 29 years), (v) emission of beta (β - ) particles along with high energy gamma ( γ)-rays, and (vi) retention of significant toxicity within sources even after service life, release of 90 Sr poses a serious threat to the biosphere. Hence, there is a need to ensure that existing 90 Sr host matrices are capable of withstanding all sorts of adversity that may arise during service and under storage/disposal

  15. Report on intercomparison run A-9/1 for the determination of 89Sr, 90Sr and 137Cs in liquid milk (1979-1980)

    International Nuclear Information System (INIS)

    Veglia, A.; Dybczynski, R.; Suschny, O.

    1981-05-01

    To provide laboratories dealing with the determination of radionuclides in milk with an opportunity of checking their analytical performance, participants were asked to determine 89 Sr, 90 Sr and 137 Cs at the nCi/1 level in simulated milk samples. Although 32 laboratories participated in this intercomparison not all of them determined all 3 radionuclides. A total of 95 laboratory means, based on 381 individual results, were reported. The ''true'' (input) values after dilution to 5 litres (details of the procedure, etc. are given) were 1.524+-0.049 nCi.1 for 89 Sr, 0.874+-0.019 nCi/1 for 90 Sr, and 1.044+-0.021 nCi/1 for 137 Cs. The uncertainties of these values are the sums of the systematic and the statistical uncertainties (confidence level 99%). The results of the determination of 90 Sr, the most important radionuclide for radiation protection and the most difficult to determine, seem to be somewhat more accurate than obtained previously (1975 and 1976). The methods of determining 90 Sr in milk are appear generally quite reliable. However, more effort would seem needed to increase the accuracy of the determination of 90 Sr and 137 Cs in milk at these activity levels

  16. The Sr/Ca-temperature relationship in coralline aragonite: Influence of variability in (Sr/Ca)[sub seawater] and skeletal growth parameters

    Energy Technology Data Exchange (ETDEWEB)

    de Villiers, S.; Shen, G.T.; Nelson, B.K. (Univ. of Washington, Seattle, WA (United States))

    1994-01-01

    This paper provides an evaluation of two of the most likely pitfalls of Sr/Ca thermometry, i.e., the effect of biogenic cycling of Sr vs. Ca in the surface ocean and the effect of variable extension rate on Sr incorporation in coralline aragonite. The authors also report calibration of the Sr/Ca-temperature relationship for three coral species, Porites lobata, Pocillopora eydouxi, and Pavona clavus, collected for the Hawaiian and Galapagos islands. Analyses of seawater samples show significant spatial and depth variability in the Sr:Ca ratio. The uncertainty introduced by this effect is estimated to be <0.2[degrees]C for corals located in tropical oligotrophic waters, and potentially larger for corals located in upwelling areas. Sr/Ca along two different growth axes of a Galapagos Pavona clavus, with annual extension rates of [approximately]6 and 12 mm/y, respectively, indicate an offset of 1-2[degrees]C, with higher Sr/Ca values associated with slower extension rates. The offset observed between the two growth axes may be the result of variations in extension and/or calcification rate. These results are important in determining past sea surface temperatures for reconstruction of paleoclimates.

  17. Conservation of (87)Sr/(86)Sr isotopic ratios during the winemaking processes of 'Red' wines to validate their use as geographic tracer.

    Science.gov (United States)

    Marchionni, Sara; Buccianti, Antonella; Bollati, Andrea; Braschi, Eleonora; Cifelli, Francesca; Molin, Paola; Parotto, Maurizio; Mattei, Massimo; Tommasini, Simone; Conticelli, Sandro

    2016-01-01

    (87)Sr/(86)Sr has been determined in wines, musts grape juices, soils and rocks from six selected vineyards of 'Cesanese' wine area. Cesanese is a monocultivar wine from a small region characterised by different geologic substrata, a key locality to test the influence of both substratum and winemaking procedure on the (87)Sr/(86)Sr of wines. Experimental work has been performed on wines from different vintage years to check possible seasonal variations. The data reveal that (87)Sr/(86)Sr does not change through time, to validate the selection of wineries performed, and in addition no isotopic variations are observed during winemaking. Indeed, no significant isotopic variations have been observed in musts and wines. These findings reinforce the hypothesis that the isotopic signature of wines is strongly related to the bioavailable fraction of the soil rather than to its bulk. The data corroborate the possibility that Sr-isotopes of high-quality wines can be used as a reliable tool for fingerprinting wine geographic provenance. Copyright © 2015 Elsevier Ltd. All rights reserved.

  18. Data report for the safety assessment SR-Site

    Energy Technology Data Exchange (ETDEWEB)

    2010-12-15

    This report compiles, documents, and qualifies input data identified as essential for the long-term safety assessment of a KBS-3 repository, and forms an important part of the reporting of the safety assessment project SR-Site. The input data concern the repository system, broadly defined as the deposited spent nuclear fuel, the engineered barriers surrounding it, the host rock, and the biosphere in the proximity of the repository. The input data also concern external influences acting on the system, in terms of climate related data. Data are provided for a selection of relevant conditions and are qualified through traceable standardised procedures

  19. Effects of chronic 90Sr ingestion in miniature swine

    International Nuclear Information System (INIS)

    Ragan, H.A.; Hackett, P.L.; Lund, J.E.; McClanahan, B.J.

    1975-01-01

    Daily 90 Sr feeding of greater than 125 μCi/day resulted in pancytopenia with death usually due to hemorrhage. At 125 μCi, pancytopenia and myelolymphoproliferative disorders appeared. At less than 125 μCi/day a dose-related neutropenia was evident. There is an apparent increased incidence of both benign and malignant tumors of soft tissue in animals fed 25 μCi/day for their lifetime. Benign uterine tumors, dental defects and marked arthritis continued to be the major diseases necessitating euthanasia in aged animals from all groups, including control swine. (U.S.)

  20. The cellular cancer resistance of the SR/CR mouse

    DEFF Research Database (Denmark)

    Koch, Janne; Hau, Jann; Jensen, Henrik Elvang

    2012-01-01

    The SR/CR mouse phenotype, first described in 1999 in BALB/c and later bred into C57BL/6 mice, is resistant to cancer formation following high doses of cancer cells administered intraperitoneally. The tumor cell targeting and destruction mechanisms have not been identified. By fluorescence...... injection showed formations of immune cells morphologically resembling polymorphonuclear granulocytes and macrophages adjoining the cancer cells. The results point to the potential involvement of innate immune cells in cancer immunology. Our data support migration of polymorphonuclear granulocytes...

  1. Determination of the radioactive concentration of 90Sr in soil

    International Nuclear Information System (INIS)

    1987-01-01

    A standardized method was developed to determine the radioactivity of 90 Sr in soil based on the activity measurement of equilibrium amount of 90 Y daughter isotope. After the wet destruction of the sample, strontium and yttrium ions are precipitated with oxalate ions. The precipitate is dissolved with cc. HNO 3 . Yttrium ions are selectively extracted from alkaline earth metal ions with TBP. The reextracted yttrium is precipitated with oxalate ions and the beta-radiation of the 'infinitely thin' layer is measured by a low-background beta-counter. (V.N.)

  2. Multiple superdeformed bands in Sr, Y, and Zr nuclei

    International Nuclear Information System (INIS)

    Reviol, W.; Sarantites, D.G.; Lerma, F.; Devlin, M.; LaFosse, D.R.; Chiara, C.J.; Wyss, R.; Baktash, C.; Jin, H.-Q.; Tabor, S.L.; Soltysik, D.; Clark, R.M.; Lee, I.Y.; Macchiavelli, A.O.; MacLeod, R.W.

    2003-01-01

    Multiple superdeformed bands in the nuclei 80-83Sr, 82-84Y, and 83,84Zr have been studied in a backed-target experiment using the Gammasphere and Microball detector arrays. For 15 bands in these nuclei, average transition quadrupole moments (Qt) have been measured accurately. Among those are two pairs of 'isospectral' bands and the Qt values obtained in each case are nearly identical. The measured Qt values and dynamical moments of inertia place stringent conditions on configuration assignments for the bands obtained from mean field calculations

  3. Data report for the safety assessment SR-Site

    International Nuclear Information System (INIS)

    2010-12-01

    This report compiles, documents, and qualifies input data identified as essential for the long-term safety assessment of a KBS-3 repository, and forms an important part of the reporting of the safety assessment project SR-Site. The input data concern the repository system, broadly defined as the deposited spent nuclear fuel, the engineered barriers surrounding it, the host rock, and the biosphere in the proximity of the repository. The input data also concern external influences acting on the system, in terms of climate related data. Data are provided for a selection of relevant conditions and are qualified through traceable standardised procedures

  4. Hydrogen Mobility in Disordered Metals Studied by $\\mu$SR

    CERN Multimedia

    2002-01-01

    A few studies of the behaviour of positive muons in metal hydrides have been made during the last three years under the code SC76, although this code is intended primarily for ``diffusion and trapping of positive muons`` in pure or very weakly doped metals. It has been shown in these studies that $\\mu$SR can provide important information even in concentrated hydrides like $ NbH _{,} _{0},7 - _{0} _{,} _{9} $ and $ Zr V _{2} H _{2} _{m}inus _{3} $ especially concerning mutual $\\mu

  5. Multi-spectrozonal detectors for temporal-resolved SR experiments

    CERN Document Server

    Fedotov, M G

    2001-01-01

    This paper considers the structure of the special integrating-mode X-ray detectors allowing the division of the range of their working energies into a few relatively independent sub-ranges. The recording of signals for all sub-ranges is carried out simultaneously (during one bunch passing in the SR source) and from the same area of the detector. It is expected that the application of such detectors for the studies of short-time processes will permit estimation of the variation of the spectrum of the recorded radiation, which violently simplifies the interpretation of the results.

  6. Geosphere process report for the safety assessment SR-Can

    International Nuclear Information System (INIS)

    Skagius, Kristina

    2006-09-01

    This report documents geosphere processes identified as relevant to the long-term safety of a KBS- repository, and forms an important part of the reporting of the safety assessment SR-Can. The detailed assessment methodology, including the role of the process report in the assessment, is described in the SR-Can Main report. The following excerpts describe the methodology, and clarify the role of this process report in the assessment. The repository system, broadly defined as the deposited spent nuclear fuel, the engineered barriers surrounding it, the host rock and the biosphere in the proximity of the repository, will evolve over time. Future states of the system will depend on the initial state of the system, a number of radiation related, thermal, hydraulic, mechanical, chemical and biological processes acting within the repository system over time, and external influences acting on the system. A methodology in ten steps has been developed for SR-Can described below. Identification of factors to consider (FEP processing): This step consists of identifying all the factors that need to be included in the analysis. Experience from earlier safety assessments and KBS-specific and international databases of relevant features, events and processes influencing long-term safety are utilised. Based on the results of the FEP processing, an SR-Can FEP catalogue, containing FEPs to be handled in SR-Can, has been established. The initial state of the system is described based on the design specifications of the KBS repository, a descriptive model of the repository site and a site-specific layout of the repository. The initial state of the fuel and the engineered components is that immediately after deposition, as described in the SR-Can Initial state report. The initial state of the geosphere and the biosphere is that of the natural system prior to excavation, as described in the site descriptive models. The repository layouts adapted to the sites are provided in underground

  7. Geosphere process report for the safety assessment SR-Can

    Energy Technology Data Exchange (ETDEWEB)

    Skagius, Kristina [Kemakta Konsult AB, Stockholm (SE)] (ed.)

    2006-09-15

    This report documents geosphere processes identified as relevant to the long-term safety of a KBS- repository, and forms an important part of the reporting of the safety assessment SR-Can. The detailed assessment methodology, including the role of the process report in the assessment, is described in the SR-Can Main report. The following excerpts describe the methodology, and clarify the role of this process report in the assessment. The repository system, broadly defined as the deposited spent nuclear fuel, the engineered barriers surrounding it, the host rock and the biosphere in the proximity of the repository, will evolve over time. Future states of the system will depend on the initial state of the system, a number of radiation related, thermal, hydraulic, mechanical, chemical and biological processes acting within the repository system over time, and external influences acting on the system. A methodology in ten steps has been developed for SR-Can described below. Identification of factors to consider (FEP processing): This step consists of identifying all the factors that need to be included in the analysis. Experience from earlier safety assessments and KBS-specific and international databases of relevant features, events and processes influencing long-term safety are utilised. Based on the results of the FEP processing, an SR-Can FEP catalogue, containing FEPs to be handled in SR-Can, has been established. The initial state of the system is described based on the design specifications of the KBS repository, a descriptive model of the repository site and a site-specific layout of the repository. The initial state of the fuel and the engineered components is that immediately after deposition, as described in the SR-Can Initial state report. The initial state of the geosphere and the biosphere is that of the natural system prior to excavation, as described in the site descriptive models. The repository layouts adapted to the sites are provided in underground

  8. Nd and Sr isotopes: implications of provenance and geological mapping

    International Nuclear Information System (INIS)

    Albuquerque, Marcio Fernando dos Santos; Horbe, Adriana Maria Coimbra; Dantas, Elton Luiz

    2015-01-01

    XRD, Nd and Sr isotopes, major, minor and traces elements quantification were applied to rocks, lateritic crusts and soils from Sumauma Supergroup and Alto Tapajos Group, in order to indicate provenance of the rocks and using lateritic products as geologic mapping tool. For the rocks, the results showed sources related to provinces Tapajos Parima, Rondonia Juruena, Sunsas, Carajas and Amazonia Central. However, the incision of Cachimbo graben allowed which the Sumauma Supergroup erosion also were source for the Alto Tapajos Group, allied to contribution of volcanics from Colider Group. Lateritic crusts and soils are correlates to bedrocks, allowing the use as geologic mapping tool. (author)

  9. Toxicity of 90Sr inhaled in a relatively insoluble form by Beagle dogs. XVII

    International Nuclear Information System (INIS)

    Snipes, M.B.; Hahn, F.F.; Muggenburg, B.A.; Mauderly, J.L.; McClellan, R.O.; Pickrell, J.A.

    1988-01-01

    This study was initiated to determine health effects resulting from inhalation of 90 Sr in relatively insoluble form. Beagle dogs were briefly exposed by inhalation to produce lung burdens of 90 Sr that ranged from 0.12 to 96 μCi (4.4-3500 kBq)/kg body weight. Exposures to the higher concentrations of 90 Sr caused radiation pneumonitis and pulmonary fibrosis, typically resulting in death 90 Sr-exposed dogs were euthanized during the past year. One remaining exposed dog and one control dog are both 14 yr old and are being maintained for lifetime observation. (author)

  10. Continuous drawing of Bi-Ca-Sr-Cu-O glass fibers from a preform

    International Nuclear Information System (INIS)

    Zheng, H.; Hu, Y.; Mackenzie, J.D.

    1991-01-01

    Several issues related to drawing Bi-Ca-Sr-Cu-O glass fibers from a preform are discussed. Continuous drawing of Bi-Ca-Sr-Cu-O glass fibers was successfully accomplished. Bi-Ca-Sr-Cu-O glass fibers are drawn above the crystallization temperature. Minimizing crystallization of the glass preforms is a key for successful drawing of the glass fibers. Two effective means, high glass melting temperature and V 2 O 5 doping, have been used to minimize the crystallization of the preforms, thus assuring the continuous drawing of Bi-Ca-Sr-Cu-O glass fibers

  11. 90Sr as a lasting toxic contamination factor in a hydroecosystem

    International Nuclear Information System (INIS)

    Dushauskiene-Duzh, R.

    1997-01-01

    Accumulation of 90 Sr in the lake Drukshiai - cooling pond of the Ignalina NPP ecosystem's biotic and abiotic components was studied. To determine concentration of 90 Sr in the samples of sediments,fishes,etc. radiochemical analysis was used. It was found that 90 Sr in hydrobionts is a principal accumulate from water. When anthropogenic factors take part in Lake Drukshiai, adsorption processes begin to dominate over the ionic exchange. Data of 90 Sr accumulation in bottom sediments, fishes organs and tissues are presented. Investigation was carried out in the period of 1992 - 1996. (author). 5 refs., 4 figs

  12. Fast determination of 90Sr in the waters surrounding the nuclear power plant

    International Nuclear Information System (INIS)

    Basarabova, B.; Dulanska, S.

    2014-01-01

    A simple and fast method was developed for determination of 90 Sr in high volumes of water samples. For determination of 90 Sr was used solid phase extraction (SPE) using commercial sorbent AnaLig(R) Sr-01 from company IBC Advanced Technologies, Inc. Determination of 90 Sr was performed with dilute solution of HNO 3 and NaOH. To achieve fast determination, vacuum system was applied, which brings significant reduction of separation time. The aim of this study was development of less expensive, time- and energy-saving method for determination of 90 Sr in comparison with conventional methods. Radiochemical strontium yield was traced by using radionuclide 85 Sr. Samples were measured with HPGe detector at energy E γ = 514 keV. By using AnaLig(R) Sr-01 yields in range 72 - 96 % were achieved. Separation based on SPE using AnaLig(R) Sr-01 employing utilization of vacuum system offers fast and effective method for determination of 90 Sr in water matrix. After ingrowth of yttrium samples were measured by Liquid Scintillation Spectrometer Packard Tricarb 2900 TR with software Quanta Smart. (authors)

  13. In-flow technology for the determination of Sr-90 concentrations in nuclear power plants

    International Nuclear Information System (INIS)

    Dissing, E.

    1982-01-01

    Outlines for a future work concerning in-flow surveillance of Sr-90 in nuclear plant process treams have been studied. The many problems involved with the task of on-line Sr-90 determination were approached in two different ways, one applying β-counting of the 64-hour daughter Y-60 with the use of the process stream itself as a Cerenkov scintillator and the other - indirect - using simultaneous measurement of the concentrations of Sr-91 and Sr-92 for the determination of the leakage route for strontium. (Author)

  14. Evidence of existence of metastable SrFe{sub 12}O{sub 19} nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Martinez Garcia, R., E-mail: rmartinez@fi.uba.ar [Laboratorio de Solidos Amorfos, INTECIN, Facultad de Ingenieria, Universidad de Buenos Aires, Paseo Colon 850, C1063ACV, Buenos Aires (Argentina); Bilovol, V.; Socolovsky, L.M. [Laboratorio de Solidos Amorfos, INTECIN, Facultad de Ingenieria, Universidad de Buenos Aires, Paseo Colon 850, C1063ACV, Buenos Aires (Argentina); Pirota, K. [Laboratorio de Materiais e Baixas Temperaturas, Instituto de Fisica ' Gleb Wataghin' , UNICAMP, 13083-970 Campinas, SP (Brazil)

    2011-12-15

    The existence of metastable hexaferrite is reported. Synthesis of strontium hexaferrite, SrFe{sub 12}O{sub 19}, at 400 deg. C was realized under controlled oxygen atmosphere. Such technique allows obtaining of SrFe{sub 12}O{sub 19} at lower temperatures than those by traditional methods (above 800 deg. C). Phase transformation occurred during a measurement of magnetization vs. temperature (heating up to 625 deg. C). The heat treatment induces a change from SrFe{sub 12}O{sub 19} to {gamma}-Fe{sub 2}O{sub 3} (as the main phase), and SrFeO{sub 2.74} to Sr{sub 2}Fe{sub 2}O{sub 5}. Together with these phase transformations, an increment in the amount of SrCO{sub 3} is detected. Magnetic study of the samples, before and after the heating, supports the structural analysis conclusions. - Highlights: > SrFe{sub 12}O{sub 19}, as the majority phase, is obtained by heat treatment at 400 deg. C under oxygen flux. > Hexaferrite nanoparticles have crystalline imperfections that make it an unstable phase. > Together with these phase transformations, an increment in the amount of SrCO{sub 3} is detected. > To our knowledge, this is the first report of the existence of metastable SrFe{sub 12}O{sub 19}.

  15. Crystal growth and scintillation properties of Pr-doped SrI2 single crystals

    Science.gov (United States)

    Yokota, Yuui; Ito, Tomoki; Yoshino, Masao; Yamaji, Akihiro; Ohashi, Yuji; Kurosawa, Shunsuke; Kamada, Kei; Yoshikawa, Akira

    2018-04-01

    Pr-doped SrI2 (Pr:SrI2) single crystals with various Pr concentrations were grown by the halide-micro-pulling-down (H-μ-PD) method, and the scintillation properties were investigated. Pr1%:SrI2 single crystal with high transparency could be grown by the H-μ-PD method while Pr2, 3 and 5%:SrI2 single crystals included some cracks and opaque parts. In the photoluminescence spectrum of the Pr1%:SrI2 single crystal, an emission peak originated from the Pr3+ ion was observed around 435 nm while the radioluminescence spectra showed an emission peak around 535 nm for the undoped SrI2 and Pr:SrI2 single crystals. Light yields of Pr1, 2, 3 and 5%:SrI2 single crystals under γ-ray irradiation were 7700, 8700, 7200 and 6700 photons/MeV, respectively. Decay times of Pr1 and 2%:SrI2 single crystals under γ-ray irradiation were 55.9 and 35.0 ns of the fast decay component, and 435 and 408 ns of the slow decay component, respectively.

  16. μSR spectroscopy on free radicals: a complement to ESR spectroscopy

    International Nuclear Information System (INIS)

    Cox, S.F.J.; Symons, M.C.R.

    1986-12-01

    The paper on ''μSR spectroscopy on free radicals'' was presented to the conference on ''Muon spin, rotation, relaxation and resonance'' Uppsala, 1986. The spectroscopic techniques for both ESR and μSR are described, along with the interpretation of the spectra, hyperfine coupling constants and radical structure. A comparison of ESR and μSR data is carried out with respect: to 1) isotope effects in organic radicals, 2) isotope effects in solids, -the isotropic muonium defect centres, and 3) the muonium defect centres in semiconductors. Radical categories examined using ESR and μSR are discussed, including new species, formation mechanisms, and ionic species. (U.K.)

  17. Conductivity of SrTiO3 based oxides in the reducing atmosphere at high temperature

    DEFF Research Database (Denmark)

    Hashimoto, Shin-Ichi; Poulsen, Finn Willy; Mogensen, Mogens Bjerg

    2007-01-01

    The conductivities of several donor-doped SrTiO3 based oxides, which were prepared in air, were studied in a reducing atmosphere at high temperature. The conductivities of all specimens increased slowly with time at 1000 degrees C in 9% H-2/N-2, even after 100 h. Nb-doped SrTiO3 showed relatively...... at 500-800 degrees C, while that of La-doped SrTiO3 dropped immediately on exposure to air. The conduction behavior of Nb-doped SrTiO3 was explained by reduction of Ti4+ and/or Nb5+ and the relatively slow oxygen diffusibility. (c) 2006 Elsevier B.V. All rights reserved.......The conductivities of several donor-doped SrTiO3 based oxides, which were prepared in air, were studied in a reducing atmosphere at high temperature. The conductivities of all specimens increased slowly with time at 1000 degrees C in 9% H-2/N-2, even after 100 h. Nb-doped SrTiO3 showed relatively...... fast reduction and high conductivity compared with the other SrTiO3 based oxides. The conductivity of Nb-doped SrTiO3 was ca. 50 S cm(-1) at 500 degrees C after reduction at 1200 degrees C. After strong reduction, the conductivity of Nb-doped SrTiO3 was almost independent of the oxygen partial pressure...

  18. Electrical resistance of SrFeO2 at ultra high pressure

    Science.gov (United States)

    Kikuchi, Masayoshi; Kagayama, Tomoko; Shimizu, Katsuya; Kageyama, Hiroshi

    2015-03-01

    SrFeO2 shows antiferromagnetic and insulating order at ambient pressure. The crystal structure of SrFeO2 has 2-dementional FeO2 plate and is interested in because this is common structure of high temperature superconductor. SrFeO2 has M-I, magnetic and spin transition with applying pressure. If magnetism disappears and metallization occurs with applying pressure, SrFeO2 may show superconductivity because of the crystal structure, so we measured electrical resistance at high pressure up to 150 GPa and low temperature down to 100 mK.

  19. Al-Sm-Eu-Sr systematics of eucrites and moon rocks Implications for planetary bulk compositions

    Science.gov (United States)

    Warren, P. H.

    1983-01-01

    Constraints are placed on the bulk compositions of the eucrite parent body (EPB) and the moon through analysis of the Eu and Sr 'anomalies' of eucrites and lunar rooks. It is noted that the elements Al, REE, and Sr are incompatible with the major minerals of these small, low-f(O2) bodies,except for plagioclase. Predictions can be derived about the concentrations of Al, REE, and Sr in samples affected by plagioclase fractionation, based on the hypothesis that these elements in the EPB and moon are all in proportions close to those in the bulk solar system. It is determined that the predictions are almost idealy fulfilled by eucrites and lunar samples. For the EPB, the ratios REE/Al, Sr/Al, and Sr/REE are found to be constrained probably within 10 percent of the chondritic ratios. For the moon, the constraints are found to be less precise: REE/Al is very probably within 25 percent of chondritic; Sr/Al and Sr/REE are probably within 35 percent of chondritic; Sr/Al and Sr/REE are probably within 35 percent of chondritic. It is concluded that there is a very strong similarity between the bulk compositions of the planets and the compositions of chondritic meteorites.

  20. Cu-NMR study on disordered Sr14Cu24O41

    International Nuclear Information System (INIS)

    Ohsugi, S.; Matsumoto, S.; Kitaoka, Y.; Matsuda, M.; Uehara, M.; Akimitsu, J.; Nagata, T.

    2002-01-01

    The ladder-Cu NMR spectrum of a structural disordered single crystal Sr 14 Cu 24 O 41 (Sr14-B) under a magnetic field H∝11 T gradually splits into two spectra with Curie-like broadening as T decreases from T SP ∝150 K. Short-range (SR) staggered polarization (SP) on the ladder planes, originating from single-hole localization, occurs. The separation of the Sr14-B spectrum ΔH deviates from the Curie-like T dependence below 20 K. This assures that spontaneous moments appear below T N ∝20 K in H∝11 T. (orig.)

  1. Adenovirus DNA binding protein inhibits SrCap-activated CBP and CREB-mediated transcription

    International Nuclear Information System (INIS)

    Xu Xiequn; Tarakanova, Vera; Chrivia, John; Yaciuk, Peter

    2003-01-01

    The SNF2-related CBP activator protein (SrCap) is a potent activator of transcription mediated by CBP and CREB. We have previously demonstrated that the Adenovirus 2 DNA Binding Protein (DBP) binds to SrCap and inhibits the transcription mediated by the carboxyl-terminal region of SrCap (amino acids 1275-2971). We report here that DBP inhibits the ability of full-length SrCap (1-2971) to activate transcription mediated by Gal-CREB and Gal-CBP. In addition, DBP also inhibits the ability of SrCap to enhance Protein Kinase A (PKA) activated transcription of the enkaphalin promoter. DBP was found to dramatically inhibit transcription of a mammalian two-hybrid system that was dependent on the interaction of SrCap and CBP binding domains. We also found that DBP has no effect on transcription mediated by a transcriptional activator that is not related to SrCap, indicating that our reported transcriptional inhibition is specific for SrCap and not due to nonspecific effects of DBP's DNA binding activity on the CAT reporter plasmid. Taken together, these results suggest a model in which DBP inhibits cellular transcription mediated by the interaction between SrCap and CBP

  2. Sr Isotopes at the Onset of the Ice Ages at the Northern Apennines

    Science.gov (United States)

    Fuchs, Rita; Lazar, Boaz; Angiolini, Lucia; Crippa, Gaia; Stein, Mordechai

    2017-04-01

    Sr isotopes can be used to constrain the marine Sr budget. The temporal variations in the 87Sr/86Sr ratios (radiogenic Sr) have been reconstructed over the past few decades based on marine macro and micro fossils data (e.g. brachiopods and foraminifera). It is used to constrain the sources and amounts of strontium that dictate the temporal variations in oceanic Sr throughout the Phanerozoic. On the other hand, the study of processes controlling the composition stable Sr isotopes (δ88/86Sr) is very new and only limited research was conducted on this topic during the past few years. Up to date, no δ88/86Sr data are available for considerable parts of Earth's history and the contribution of the potential Sr sources to the oceans is poorly constrained. Here, we set to examine the behavior of radiogenic and stable Sr isotopes in the marine environment of the northern Apennines (Italy) during the time interval of the late Pliocene to early-Middle Pleistocene - upon the onset of ice ages in the northern latitudes. We collected fossil mollusks from outcrops of the Arda and Stirone Rivers that are rich in bivalves, brachiopods, foraminifera (that were used for establishing the chronostratigraphy of the sections) and other genera. Ecological and sedimentological analysis of the section suggest a normal marine environment of depth range of several tens of meters that existed on the southern flanks of the large Po embayment. In order to evaluate the potential of the fossil assemblages in the Arda and Stirone sections to serve as reliable recorders of the marine δ88/86Sr of seawater during the desired period, we examined mineralogical and chemical properties of the fossils (e.g. distribution of trace elements like Sr and Mg in the skeletons, microstructures like secondary fillings of punctate shells in brachiopod) and measured the 87Sr/86Sr ratios. Among the species analyzed, Aequipecten opercularis (bivalve) and Glycymeris inflata (bivalve) have aragonite skeletons that

  3. Subsolidus phase relations of the SrO–SbOx–CuO system at 1140K in air

    DEFF Research Database (Denmark)

    Grivel, J.-C.; Norby, Poul; Andersen, Niels Hessel

    2014-01-01

    The subsolidus phase relations of the SrO–SbOx–CuO system were investigated in air. The samples were equilibrated at 1140K. Under these conditions, 7 binary oxide phases are stable: Sr2CuO3, SrCuO2, Sr14Cu24O41−δ, CuSb2O6, SrSb2O6, Sr2Sb2O7 and Sr7Sb2O12. The ternary section contains 10 three......-phase regions. A new ternary oxide phase with an approximate Sr3Sb2CuO9 composition of was identified. It structure is related to that of Sr8W3CuO18. This phase is not superconducting above 2K. Instead, the magnetic susceptibility indicates onset of weak ferro- or ferrimagnetism at T≈30K....

  4. Frequency of anti-glycoprotein Ia/IIa (anti-HPA-5b,-5a and anti-glycoprotein IIb/IIIa (anti-HPA-1a,-3a,-4a alloantibodies in multiparous women of African descent

    Directory of Open Access Journals (Sweden)

    Zaccheaus A Jeremiah

    2010-05-01

    Full Text Available Zaccheaus A Jeremiah1, Justina E Oburu2, Osaro Erhabor1, Fiekumo I Buseri1, Teddy C Adias31Haematology and Blood Transfusion Science Unit, Department of Medical Laboratory Sciences, College of Health Sciences, Niger Delta University, Wilberforce Island, Nigeria; 2Department of Haematology and Blood Transfusion, University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria; 3Rivers State University of Science and Technology, Port Harcourt, NigeriaBackground: Human platelet antibodies are often implicated in some disease conditions, such as neonatal alloimmune thrombocytopenia (NAIT, idiopathic thrombocytopenic purpura (ITP and platelet refractoriness. The frequencies of these alloantibodies have not been reported in Nigeria and West Africa.Methods: Screening for allontibodies to human platelet antigens (HPA was undertaken using the GTI PakPlus® qualitative solid phase ELISA reagent. Platelet count was done using the ICSH approved procedure using 1% ammonium oxalate reagent.Study design: A cross-section of apparently healthy adult Nigerian multiparous non-pregnant women, who were staff of a tertiary health facility in the Niger Delta, Nigeria, were screened for alloantibodies to human platelet antigens.Results: Of the one hundred (100 women screened, the prevalence of anti-glycoprotein IIb/IIIa (anti-HPA-Ia,-3a,-4a was zero percent (0%, anti-glycoprotein Ia/IIa (anti-HPA-5b accounted for 30% of results, while anti-glycoprotein Ia/IIa (anti-HPA-5a was 18%. Parity was found to exert significant influence on the development to HPA antibodies (Fisher’s Exact Test = 11.683, P < 0.05; 13.577, P < 0.01. The platelet count of the women did not appear to exert any influence on the development of the antibodies (P > 0.05.Conclusion: This study has observed a high prevalence of anti-HPA-5b in our sample population. The prevalence of alloantibodies to HPA antigens was found to associate strongly with parity. These results indicate that there is a

  5. Kinetic and mineralogic controls on the evolution of groundwater chemistry and 87Sr/86Sr in a sandy silicate aquifer, northern Wisconsin, USA

    Science.gov (United States)

    Bullen, T.D.; Krabbenhoft, D.P.; Kendall, C.

    1996-01-01

    Substantial flowpath-related variability of 87Sr/86Sr is observed in groundwaters collected from the Trout Lake watershed of northern Wisconsin. In the extensive shallow aquifer composed of sandy glacial outwash, groundwater is recharged either by seepage from lakes or by precipitation that infiltrates the inter-lake uplands. 87Sr/86Sr of groundwater derived mainly as seepage from a precipitation-dominated lake near the head of the watershed decreases with progressive water chemical evolution along its flowpath due primarily to enhanced dissolution of relatively unradiogenic plagioclase. In contrast, 87Sr/86Sr of groundwater derived mainly from precipitation that infiltrates upland areas is substantially greater than that of precipitation collected from the watershed, due to suppression of plagioclase dissolution together with preferential leaching of Sr from radiogenic phases such as K-feldspar and biotite. The results of a column experiment that simulated the effects of changing residence time of water in the aquifer sand indicate that mobile waters obtain relatively unradiogenic Sr, whereas stagnant waters obtain relatively radiogenic Sr. Nearly the entire range of strontium-isotope composition observed in groundwaters from the watershed was measured in the experimental product waters. The constant mobility of water along groundwater recharge flowpaths emanating from the lakes promotes the dissolution of relatively unradiogenic plagioclase, perhaps due to effective dispersal of clay mineral nuclei resulting from dissolution reactions. In contrast, episodic stagnation in the unsaturated zone along the upland recharge flowpaths suppresses plagioclase dissolution, perhaps due to accumulation of clay mineral nuclei on its reactive surfaces. Differences in redox conditions along these contrasting flowpaths probably enhance the observed differences in strontium isotope behavior. This study demonstrates that factors other than the calculated state of mineral saturation

  6. Effects of Dy, Sr and Die Casting on Microstructure, Mechanical and Corrosion Properties of Mg-Dy-Sr-Nd-Zr Alloys

    Science.gov (United States)

    Liu, Dexue; Yin, Xunyan; Pang, Xin; Hu, Shiwen; Ding, Yutian

    2017-08-01

    By adding 2, 6 and 10 wt.% Dy and 0.5, 1.5 and 2 wt.% Sr elements to Mg-2.4Nd-0.5Zr alloys and adopting die-casting process for biomedical Mg-10Dy-0.5Sr-2.4Nd-0.5Zr alloys, the effects of Dy and Sr elements and die-casting process on the microstructure, mechanical properties and corrosion resistance of Mg-Dy-Sr-Nd-Zr alloys were investigated. The new biomedical Mg-10Dy-0.5Sr-2.4Nd-0.5Zr alloys were designed, and the grain size of the as-cast new alloy was refined to 70 μm and distributed equably. The ultimate tensile strength increased with increasing Dy content and decreasing Sr content. The corrosion rate decreased firstly and then increased with increasing Dy content and decreased with increasing Sr content. By adjusting the content of Sr and Dy, the ultimate tensile strength of as-cast new Mg-10Dy-0.5Sr-2.4Nd-0.5Zr alloys increased to 203 MPa, elongation was 7.4%, and the corrosion rate decreased to 0.48 mm/a. The elongation rate increased to 10.2% after the new biomedical alloys were processed by die casting with an refine-grained microstructure of 18 μm, meanwhile the ultimate tensile strength decreased to 180 MPa, and the corrosion rate was 1.29 mm/a.

  7. Sr/Ca ratios of modern and fossil Favia corals from the Korea Strait; implications for application of coral Sr/Ca thermometry in a middle latitude region

    Science.gov (United States)

    Seo, I.; Lee, Y.; Watanabe, T.; Shimamura, M.; Yamano, H.; Yoo, C.; Hyeong, K.

    2011-12-01

    Favia, a hermatypic reef building coral, is widely distributed from equator to northern latitudinal limit of coral distribution. An 150-mm-long living, grown for 21 years, and 50-mm-long fossil (2600 cal yr BP) Favia specimens, grown for 13 years, were collected from the Iki Island, Japan (34°48'N, 129°39'E) and analyzed for Sr/Ca ratios, in order to test for a high-resolution paleo-SST proxy. The modern and fossil Favia samples reveal clear annual seasonality in density bands and the measured Sr/Ca ratios. In the modern coral, however, the large inter-annual variability of winter Sr/Ca indicates smoothing of environmental signals during cold season due to very slow growth or frequent growth cessations. An SST - Sr/Ca equation, Sr/Ca (mmol/mol) = 10.428 - 0.049 × SST (°C), constructed under the assumption of growth stopping below 14°C, predicts the observed annual summer maximums within an error range of ± 1.2°C. Large inter-annual variability of Sr/Ca is also observed in the fossil coral, but even in the warm season, indicating more frequent coral growth disturbances due to colder condition at 2600 cal yr BP. With an assumption that growth disturbance had the least effect on the lowest Sr/Ca, the equation predicts summer maximum temperature of 24.6°C, ~ 2°C lower than the present. The SST - Sr/Ca equation established in this study successfully reconstructs SSTs of a subtropical region from reported literature values, suggesting the applicability of Sr/Ca thermometry of Favia in a wide range of climate settings.

  8. Physiological studies in heterozygous calcium sensing receptor (CaSR gene-ablated mice confirm that the CaSR regulates calcitonin release in vivo

    Directory of Open Access Journals (Sweden)

    Kovacs Christopher S

    2004-04-01

    Full Text Available Abstract Background The calcium sensing receptor (CaSR regulates serum calcium by suppressing secretion of parathyroid hormone; it also regulates renal tubular calcium excretion. Inactivating mutations of CaSR raise serum calcium and reduce urine calcium excretion. Thyroid C-cells (which make calcitonin express CaSR and may, therefore, be regulated by it. Since calcium stimulates release of calcitonin, the higher blood calcium caused by inactivation of CaSR should increase serum calcitonin, unless CaSR mutations alter the responsiveness of calcitonin to calcium. To demonstrate regulatory effects of CaSR on calcitonin release, we studied calcitonin responsiveness to calcium in normal and CaSR heterozygous-ablated (Casr+/- mice. Casr+/- mice have hypercalcemia and hypocalciuria, and live normal life spans. Each mouse received either 500 μl of normal saline or one of two doses of elemental calcium (500 μmol/kg or 5 mmol/kg by intraperitoneal injection. Ionized calcium was measured at baseline and 10 minutes, and serum calcitonin was measured on the 10 minute sample. Results At baseline, Casr+/- mice had a higher blood calcium, and in response to the two doses of elemental calcium, had greater increments and peak levels of ionized calcium than their wild type littermates. Despite significantly higher ionized calcium levels, the calcitonin levels of Casr+/- mice were consistently lower than wild type at any ionized calcium level, indicating that the dose-response curve of calcitonin to increases in ionized calcium had been significantly blunted or shifted to the right in Casr+/- mice. Conclusions These results confirm that the CaSR is a physiological regulator of calcitonin; therefore, in response to increases in ionized calcium, the CaSR inhibits parathyroid hormone secretion and stimulates calcitonin secretion.

  9. The geographic distribution of Sr isotopes from surface waters and soil extracts over the island of Bornholm (Denmark) – A base for provenance studies in archaeology and agriculture

    DEFF Research Database (Denmark)

    Frei, Robert; Frei, Karin Margarita

    2013-01-01

    In this paper we report the Sr isotope signatures, and Sr, Al and Na concentrations of 30 surface waters (lakes/ponds and rivers/creeks) and 19 soil sample extracts from the island of Bornholm (Denmark) and present a categorized 87Sr/86Sr value distribution map that may serve as a base for proven...... and low 87Sr/86Sr values, and a source with lower [Sr] delivering radiogenic Sr to the surface waters, which we equate with Sr leached from the products of mineral weathering (soils)....

  10. CAGE IIIA Distributed Simulation Design Methodology

    Science.gov (United States)

    2014-05-01

    Performance Assessment System CRAM Counter-Rocket, Artillery, Mortar CSD Coalition Shared Database CSV Comma Separated Value DDG Guided-Missile...Point of Origin POI Point of Impact PPLI Precise Participant Location and Identification R&D Research and Development RADAR Radio Detection And

  11. 87Sr/86Sr Concentrations in the Appalachian Basin: A Review

    Energy Technology Data Exchange (ETDEWEB)

    Mordensky, Stanley P. [Oak Ridge Inst. for Science and Education (ORISE), Oak Ridge, TN (United States); National Energy Technology Lab. (NETL), Albany, OR (United States); Lieuallen, A. Erin [Oak Ridge Inst. for Science and Education (ORISE), Oak Ridge, TN (United States); National Energy Technology Lab. (NETL), Albany, OR (United States); Verba, Circe [National Energy Technology Lab. (NETL), Albany, OR (United States); Hakala, Alexandra [National Energy Technology Lab. (NETL), Pittsburgh, PA, (United States)

    2016-06-16

    This document reviews 87Sr/86Sr isotope data across the Appalachian Basin from existing literature to show spatial and temporal variation. Isotope geochemistry presents a means of understanding the geochemical effects hydraulic fracturing may have on shallow ground substrates. Isotope fractionation is a naturally occurring phenomenon brought about by physical, chemical, and biological processes that partition isotopes between substances; therefore, stable isotope geochemistry allows geoscientists to understand several processes that shape the natural world. Strontium isotopes can be used as a tool to answer an array of geological and environmental inquiries. In some cases, strontium isotopes are sensitive to the introduction of a non-native fluid into a system. This ability allows strontium isotopes to serve as tracers in certain systems. Recently, it has been demonstrated that strontium isotopes can serve as a monitoring tool for groundwater and surface water systems that may be affected by hydraulic fracturing fluids (Chapman et al., 2013; Kolesar Kohl et al., 2014). These studies demonstrated that 87Sr/86Sr values have the potential to monitor subsurface fluid migration in regions where extraction of Marcellus Shale gas is occurring. This document reviews publicly available strontium isotope data from 39 sample locations in the Appalachian Basin (Hamel et al., 2010; Chapman et al., 2012; Osborn et al., 2012; Chapman et al., 2013; Capo et al., 2014; Kolesar Kohl et al., 2014). The data is divided into two sets: stratigraphic (Upper Devonian/Lower Mississippi, Middle Devonian, and Silurian) and groundwater. ArcMap™ (ESRI, Inc.) was used to complete inverse distance weighting (IDW) analyses for each dataset to create interpolated surfaces in an attempt to find regional trends or variations in strontium isotopic values across the Appalachian Basin. 87Sr/86Sr varies up to ~ 0.011 across the

  12. Topotactic phase transformation of the brownmillerite SrCoO2.5 to the perovskite SrCoO3- δ.

    Science.gov (United States)

    Jeen, H; Choi, W S; Freeland, J W; Ohta, H; Jung, C U; Lee, H N

    2013-07-19

    Pulsed laser epitaxy of brownmillerite SrCoO2.5 thin films and their phase transformation to the perovskite SrCoO3-δ are investigated. While the direct growth of the fully oxidized perovskite films is found to be an arduous task, filling some of oxygen vacancies into SrCoO2.5 by topotactic oxidation accompanies systematic evolution of electronic, magnetic, and thermoelectric properties, useful for many information and energy technologies. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. A novel approach to Ca-Sr separation in the determination of 90Sr using inorganic exchangers

    International Nuclear Information System (INIS)

    Stella, R.; Pavia Univ.; Valentini, M.T.G.; Maggi, L.

    1992-01-01

    A procedure for 90 Sr determination in calcium rich samples is presented. It is based on the precipitation of calcium oxalate in homogeneous solution and under controlled conditions to minimize the comprecipitation of strontium. The latter is subsequently separated as carbonate and radiochemical purification is completed by ion exchange chromatography on two inorganic exchangers: PRTD (partially reduced tin dioxide) and CUCR (copper chromate). The procedure was applied to environmental samples such as ashed sediment, fish and vegetable and results are reported. (author) 15 refs.; 2 tabs

  14. Strontium-90 (90Sr) determination using liquid scintillation counting

    International Nuclear Information System (INIS)

    Cheberle, L.T.V.; Rosa, M.M.L.; Ferreira, M.T.; Taddei, M.H.T.

    2015-01-01

    This procedure describes a method for separation and measurement of strontium 90 Sr in water, soils, and biological samples. Water samples may be concentrated using evaporation or calcium phosphate coprecipitation. Soils and biological materials must be dissolved using wet digestion. Tracers and carriers must be added before the attack. Radioactive strontium is separated employing a specific resin before determination by liquid scintillation counting using the double energetic window method. The resin is used to concentrate strontium from samples. Stable strontium is used to monitor method yields and correct results to improve precision and accuracy. The presence of elemental strontium in the sample may bias the gravimetric yield determination. If it is suspected that natural strontium is present in the sample, its concentration should be determined by a suitable means (ICP), and the yield calculation properly modified. Sr-Spec resin with an 8M HNO 3 load solution is used to effectively remove 140 Ba and 40 K isotopes, as well as other interferences from the matrix. Tetravalent plutonium, neptunium, cerium and ruthenium, however, are not removed using nitric acid. The radiochemical procedure was tested using PROCORAD intercomparison exercises and PNI samples. (author)

  15. Model summary report for the safety assessment SR-Can

    Energy Technology Data Exchange (ETDEWEB)

    Vahlund, Fredrik

    2006-10-15

    This document is the model summary report for the safety assessment SR-Can. In the report, the quality assurance measures conducted for the assessment codes are presented together with the chosen methodology. In the safety assessment SR-Can, a number of different computer codes are used. In order to better understand how these codes are related Assessment Model Flowcharts, AMFs, have been produced within the project. From these, it is possible to identify the different modelling tasks and consequently also the different computer codes used. A large number of different computer codes are used in the assessment of which some are commercial while others are developed especially for the current assessment project. QA requirements must on the one hand take this diversity into account and on the other hand be well defined. In the methodology section of the report the following requirements are defined: It must be demonstrated that the code is suitable for its purpose; It must be demonstrated that the code has been properly used; and, It must be demonstrated that the code development process has followed appropriate procedures and that the code produces accurate results. Although the requirements are identical for all codes, the measures used to show that the requirements are fulfilled will be different for different codes (for instance due to the fact that for some software the source-code is not available for review). Subsequent to the methodology section, each assessment code is presented and it is shown how the requirements are met.

  16. Experimental investigation of mouse kidney aging with SR PCI technology

    Science.gov (United States)

    Yifeng, P.; Zehua, Z.; Guohao, D.; Tiqiao, X.; Hongjie, X.; Peiping, Z.

    2013-08-01

    Objective. Basing on the coherence character of the Synchrotron radiation (SR), the mouse kidney study is performed using the propagation-based phase-contrast imaging (PCI) technology which as one approach of the phase contrasts imaging (PCI). The aim of this paper was to visualize the kidney at different ages and evaluate the latent value of aging mechanism with SR phase contrast imaging technology. Methods. The experiments were performed at the BL13W1 line of the SSRF (the Shanghai synchrotron radiation facility), the samples were soaked in 10% formalin solution, the mouse kidneys at different ages were imaged on the shelf in the propagation-based phase-contrast imaging setup and captured with CCD. The captured images were analyzed and compared. Results. When the distance is 50 cm between the samples and imaging plate, good contrast and high resolution were obtained in the propagation-based phase-contrast imaging (PCI), as such renal capsule revealed well, and the resolution reach to 30 micron; there is significant difference in the shape and vessels structures among the mouse kidneys at different age. Conclusion. The PCI is good for the applying of main light element organization imaging, the difference in shape and vessels structure between the young and old mouse kidney maybe indicated at some extent with the propagation-based phase-contrast imaging technology.

  17. Rapid determination of actinides and (90)Sr in river water.

    Science.gov (United States)

    Habibi, A; Boulet, B; Gleizes, M; Larivière, D; Cote, G

    2015-07-09

    Nuclear accidents occurred in latest years highlighted the difficulty to achieve, in a short time, the quantification of alpha and beta emitters. Indeed, most of the existing methods, though displaying excellent performances, can be very long, taking up to several weeks for some radioisotopes, such as (90)Sr. This study focuses on alpha and beta radioisotopes which could be accidentally released from nuclear installations and which could be measured by inductively coupled plasma mass spectrometer (ICP-MS). Indeed, a new and rapid separation method was developed for (234,235,236,238)U, (230,232)Th, (239,240)Pu, (237)Np, (241)Am and (90)Sr. The main objective was to minimize the duration of the separation protocol by the development of a unique radiochemical procedure with elution media compatible with ICP-MS measurements. Excellent performances were obtained with spiked river water samples. These performances are characterized by total yields exceeding 80% for all monitored radionuclides, as well as good reproducibility (RSD≤10%, n=12). The proposed radiochemical separation (including counting time) required less than 7h for a batch of 8 samples. Copyright © 2015 Elsevier B.V. All rights reserved.

  18. Model summary report for the safety assessment SR-Can

    International Nuclear Information System (INIS)

    Vahlund, Fredrik

    2006-10-01

    This document is the model summary report for the safety assessment SR-Can. In the report, the quality assurance measures conducted for the assessment codes are presented together with the chosen methodology. In the safety assessment SR-Can, a number of different computer codes are used. In order to better understand how these codes are related Assessment Model Flowcharts, AMFs, have been produced within the project. From these, it is possible to identify the different modelling tasks and consequently also the different computer codes used. A large number of different computer codes are used in the assessment of which some are commercial while others are developed especially for the current assessment project. QA requirements must on the one hand take this diversity into account and on the other hand be well defined. In the methodology section of the report the following requirements are defined: It must be demonstrated that the code is suitable for its purpose; It must be demonstrated that the code has been properly used; and, It must be demonstrated that the code development process has followed appropriate procedures and that the code produces accurate results. Although the requirements are identical for all codes, the measures used to show that the requirements are fulfilled will be different for different codes (for instance due to the fact that for some software the source-code is not available for review). Subsequent to the methodology section, each assessment code is presented and it is shown how the requirements are met

  19. Planning of SR experiments using DAC at PF

    International Nuclear Information System (INIS)

    Shimomura, Osamu; Kikegawa, Takumi

    1996-06-01

    The history of the synchrotron radiation experiment using diamond anvil cell (DAC) since it was carried out at PF for the first time in 1983 is briefly described. It was shown that the combination of DAC, SR and image plate (IP) is very effective, and the experimental system for exclusive use was made. The effort of searching for high light flux beam and the utilization of high sensitivity detectors have been investigated. At the time like this, in order to advance further the DAC research at PF, it was decided to hold the workshop for exchanging the opinions of those concerned. At the workshop, as to the maintenance plan for the DAC experimental station, the station for x-ray analysis under special environment BL18C which is being constructed now and the possibility of high light flux experiment which is planned at BL13B are introduced. The workshop is held on August 8 and 9, 1995 at the National Laboratory for High Energy Physics, and lectures are given on ultrahigh pressure experiment at PF, BL18C and DIP320 equipment, low temperature DAC, in situ low temperature ruby photometric system, new light-collecting system at BL13B2, laser-heating DAC, CCD detector, Rietveld analysis, MEM analysis, experience of high luminance SR and so on. (K.I.)

  20. First Combined SCT/TRT Cosmics Seen in SR1

    CERN Multimedia

    M. Jose Costa; H. Pernegger

    A major milestone for the Inner Detector project has been accomplished in early May as cosmic rays going through both the barrel Semiconductor Tracker (SCT) and Transition Radiation Tracker (TRT) have been successfully recorded in the SR1 building on the ATLAS experimental site at CERN. A cosmic-ray track in the combined SCT-TRT barrel As reported also in this issue of the eNews, in February of this year the SCT barrel was inserted into the TRT in the SR1 building. One eighth of the TRT barrel and a quarter of the SCT barrel were then cabled to power supplies and to the data acquisition system in order to verify the good operation of the detector before installation in the ATLAS cavern. After first checks of noise levels in the final detectors, a critical goal was to study its response to cosmic rays using a set of scintillators to give the external trigger, thus undertaking the enormous challenge of integrating the full chain of the detectors, the DAQ, and the reconstruction and monitoring software. A ...

  1. Anisotropic Magnetoresistance in Antiferromagnetic Sr_{2}IrO_{4}

    Directory of Open Access Journals (Sweden)

    C. Wang

    2014-11-01

    Full Text Available We report point-contact measurements of anisotropic magnetoresistance (AMR in a single crystal of antiferromagnetic Mott insulator Sr_{2}IrO_{4}. The point-contact technique is used here as a local probe of magnetotransport properties on the nanoscale. The measurements at liquid nitrogen temperature reveal negative magnetoresistances (up to 28% for modest magnetic fields (250 mT applied within the IrO_{2} a-b plane and electric currents flowing perpendicular to the plane. The angular dependence of magnetoresistance shows a crossover from fourfold to twofold symmetry in response to an increasing magnetic field with angular variations in resistance from 1% to 14%. We tentatively attribute the fourfold symmetry to the crystalline component of AMR and the field-induced transition to the effects of applied field on the canting of antiferromagnetic-coupled moments in Sr_{2}IrO_{4}. The observed AMR is very large compared to the crystalline AMRs in 3d transition metal alloys or oxides (0.1%–0.5% and can be associated with the large spin-orbit interactions in this 5d oxide while the transition provides evidence of correlations between electronic transport, magnetic order, and orbital states. The finding of this work opens an entirely new avenue to not only gain a new insight into physics associated with spin-orbit coupling but also to better harness the power of spintronics in a more technically favorable fashion.

  2. Pixel Detector Trial Assembly Test in the SR1 building

    CERN Multimedia

    D. Giugni

    2004-01-01

    During the last two months the Pixel group [LBL, Milan and Wuppertal] made a successful integration test on the mechanics of the barrel. The scope of the test was to qualify the integration procedures and the various assembling tools. The test took place in the clean room of the SR1 building at CERN, where the detector has been assembled around a dummy beam pipe made of Stainless Steel. The process is rather complex: the shells come in two parts and they have to be clamped together to get the full shell. This operation is carried out by a dedicated tool which is shown to the right in the picture below. The layer 1 shell is clamped around a "service" pipe that will be used for moving the full layer to the integration tool [ITT] which is visible on the left. View of the tools devoted to the Pixel barrel integration in the SR1 building Also visible in the picture is the global frame that is actually held by the tool. It will engage the layers sliding onto the rails. The first two layers are sequentially...

  3. Strontium isotope fractionation during strontianite (SrCO3) dissolution, precipitation and at equilibrium

    Science.gov (United States)

    Mavromatis, Vasileios; Harrison, Anna L.; Eisenhauer, Anton; Dietzel, Martin

    2017-12-01

    In this study we examine the behavior of stable Sr isotopes between strontianite [SrCO3] and reactive fluid during mineral dissolution, precipitation, and at chemical equilibrium. Experiments were performed in batch reactors at 25 °C in 0.01 M NaCl solutions wherein the pH was adjusted by bubbling of a water saturated gas phase of pure CO2 or atmospheric air. The equilibrium Sr isotope fractionation between strontianite and fluid after dissolution of the solid under 1 atm CO2 atmosphere was estimated as Δ88/86SrSrCO3-fluid = δ88/86Sr SrCO3 - δ88/86Srfluid = -0.05 ± 0.01‰. On the other hand, during strontianite precipitation, an enrichment of the fluid phase in 88Sr, the heavy isotopomer, was observed. The evolution of the δ88/86Srfluid during strontianite precipitation can be modeled using a Rayleigh distillation approach and the estimated, kinetically driven, fractionation factor αSrCO3-fluid between solid and fluid is calculated to be 0.99985 ± 0.00003 corresponding to Δ88/86SrSrCO3-fluid = -0.15‰. The obtained results further support that under chemical equilibrium conditions between solid and fluid a continuous exchange of isotopes occurs until the system approaches isotopic equilibrium. This isotopic exchange is not limited to the outer surface layer of the strontianite crystal, but extends to ∼7-8 unit cells below the crystal surface. The behavior of Sr isotopes in this study is in excellent agreement with the concept of dynamic equilibrium and it suggests that the time needed for achievement of chemical equilibrium is generally shorter compared to that for isotopic equilibrium. Thus it is suggested that in natural Sr-bearing carbonates an isotopic change may still occur close to thermodynamic equilibrium, despite no observable change in aqueous elemental concentrations. As such, a secondary and ongoing change of Sr isotope signals in carbonate minerals caused by isotopic re-equilibration with fluids has to be considered in order to use Sr

  4. Study on Sr-Nd isotopes of mesozoic-cenozoic granites in Qinghai-Tibetan plateau

    International Nuclear Information System (INIS)

    Qiu Ruizhao; Deng Jinfu; Zhou Su; Xiao Qinghui; Cai Zhiyong

    2003-01-01

    Mesozoic-Cenozoic magmatic activities were intensive in Qinghai-Tibetan plateau. Nd-Sr isotopic compositions of representative granitic plutons in western Qinghai-Tibetan plateau are reported in this paper. Combining with past isotopic data, which has reported in eastern Qinghai-Tibetan plateau, Sr-Nd isotopic compositions and material source and genesis of Mesozoic and Cenozoic granites in Qinghai-Tibetan plateau have been studied. The research result indicates there are three types of granite existing in Qinghai-Tibetan plateau, the granites of Late stage of Yanshan Period which distributing on north and south boundary of Gandes block (namely in north and south granitic belts of Dangdes) and cause of oceanic crust subduction, have ( 87 Sr/ 86 Sr)i of 0.7041-0.7064, ε (Nd) t of +2.5 - +5.7 and TDM age of 312-562 Ma, positive ε Nd, low ( 87 Sr/ 86 Sr)i ratio and young Nd model ages suggest relatively high contents of mantle-derived components in their sources, and this type granite might melt from subduction oceanic crust. The granites occurred intra-Gangdes block which were caused by collision of continent and post-collision, have ( 87 Sr/ 86 Sr)i of 0.706-0.719, ε (Nd) t of -5.3 - -8.3 and TDM age of 1323-1496 Ma, negative ε Nd, relative high ( 87 Sr/ 86 Sr)i ratio with an mid-Proterozoic Nd model ages, suggest granite has the mixing genesis of mantle-derived components and old crustal components in their sources. With relatively small variation range in ε (Nd) t and TDM age, it might imply granitic isotopic source in Gandes block to keep relative homogenization in long period. The granites in Himalayan block which there is not oceanic material to join in melting and to cause of intra-continental subduction, has most ( 87 Sr/ 86 Sr)i ratio more than 0.720, ε (Nd) t of -10.3 - -16.3 and TDM age of 1792-2206 Ma, high ( 87 Sr/ 86 Sr)i ratio, low negative ε (Nd)t with old Nd isotopic model ages and consistent with the Sr, Nd isotopic compositions of basement

  5. Application of LA-MC-ICP-MS for analysis of Sr isotope ratios in speleothems

    Science.gov (United States)

    Weber, Michael; Scholz, Denis; Wassenburg, Jasper A.; Jochum, Klaus Peter; Breitenbach, Sebastian

    2017-04-01

    Speleothems are well established climate archives. In order to reconstruct past climate variability, several geochemical proxies, such as δ13C and δ18O as well as trace elements are available. Since several factors influence each individual proxy, robust interpretation is often hampered. This calls for multi-proxy approaches involving additional isotope systems that can help to delineate the role of different sources of water within the epikarst and changes in soil composition. Sr isotope ratios (87Sr/86Sr) have been shown to provide useful information about water residence time and water mixing in the host rock. Furthermore, Sr isotopes are not fractionated during calcite precipitation, implying that the 87Sr/86Sr ratio of the speleothem provides a direct record of the drip water. While most speleothem studies applying Sr isotopes used the TIMS methodology, LA-MC-ICP-MS has been utilized for several other archives, such as otoliths and teeth. This method provides the advantage of faster data acquisition, higher spatial resolution, larger sample throughput and the absence of chemical treatment prior to analysis. Here we present the first LA-MC-ICP-MS Sr isotope data for speleothems. The analytical uncertainty of our LA-MC-ICP-MS Sr data is in a similar range as for other carbonate materials. The results of different ablation techniques (i.e. line scan and spots) are reproducible within error, implying that the application of this technique on speleothems is possible. In addition, several comparative measurements of different carbonate reference materials (i.e. MACS-3, JCt-1, JCp-1), such as tests with standard bracketing and comparison of the 87Sr/86Sr ratios with nanosecond laser ablation system and a state-of-the-art femtosecond laser ablation system, show the robustness of the method. We applied the method to samples from Morocco (Grotte de Piste) and India (Mawmluh Cave). Our results show only very small changes in the 87Sr/86Sr ratios of both speleothems

  6. Twentieth century warming of the tropical Atlantic captured by Sr-U paleothermometry

    Science.gov (United States)

    Alpert, Alice E.; Cohen, Anne L.; Oppo, Delia W.; DeCarlo, Thomas M.; Gaetani, Glenn A.; Hernandez-Delgado, Edwin A.; Winter, Amos; Gonneea, Meagan

    2017-01-01

    Coral skeletons are valuable archives of past ocean conditions. However, interpretation of coral paleotemperature records is confounded by uncertainties associated with single-element ratio thermometers, including Sr/Ca. A new approach, Sr-U, uses U/Ca to constrain the influence of Rayleigh fractionation on Sr/Ca. Here we build on the initial Pacific Porites Sr-U calibration to include multiple Atlantic and Pacific coral genera from multiple coral reef locations spanning a temperature range of 23.15–30.12°C. Accounting for the wintertime growth cessation of one Bermuda coral, we show that Sr-U is strongly correlated with the average water temperature at each location (r2 = 0.91, P < 0.001, n = 19). We applied the multispecies spatial calibration between Sr-U and temperature to reconstruct a 96 year long temperature record at Mona Island, Puerto Rico, using a coral not included in the calibration. Average Sr-U derived temperature for the period 1900–1996 is within 0.12°C of the average instrumental temperature at this site and captures the twentieth century warming trend of 0.06°C per decade. Sr-U also captures the timing of multiyear variability but with higher amplitude than implied by the instrumental data. Mean Sr-U temperatures and patterns of multiyear variability were replicated in a second coral in the same grid box. Conversely, Sr/Ca records from the same two corals were inconsistent with each other and failed to capture absolute sea temperatures, timing of multiyear variability, or the twentieth century warming trend. Our results suggest that coral Sr-U paleothermometry is a promising new tool for reconstruction of past ocean temperatures.

  7. 90Sr liquid scintillation urine analysis utilizing different approaches for tracer recovery.

    Energy Technology Data Exchange (ETDEWEB)

    Piraner, Olga; Preston, Rose T.; Shanks, Sonoya Toyoko; Jones, Robert

    2010-08-01

    90Sr is one of the isotopes most commonly produced by nuclear fission. This medium lived isotope presents serious challenges to radiation workers, the environment, and following a nuclear event, the general public. Methods of identifying this nuclide have been in existence for a number of years (e.g. Horwitz, E.P. [1], Maxwell, S.L.[2], EPA 905.0 [3]) which are time consuming, requiring a month or more for full analysis. This time frame is unacceptable in the present security environment. It is therefore important to have a dependable and rapid method for the determination of Sr. The purposes of this study are to reduce analysis time to less than half a day by utilizing a single method of radiation measurement while continuing to yield precise results. This paper presents findings on three methods that can meet this criteria; (1) stable Sr carrier, (2) 85Sr by gamma spectroscopy, and (3) 85Sr by LSC. Two methods of analyzing and calculating the 85Sr tracer recovery were investigated (gamma spectroscopy and a low energy window-Sr85LEBAB by LSC) as well as the use of two different types of Sr tracer (85Sr and stable Sr carrier). Three separate stock blank urine samples were spiked with various activity levels of 239Pu, 137Cs, 90Sr /90Y to determine the effectiveness of the Eichrome Sr-spec resin 2mL extractive columns. The objective was to compare the recoveries of 85Sr versus a stable strontium carrier, attempt to compare the rate at which samples can be processed by evaluating evaporation, neutralization, and removing the use of another instrument (gamma spectrometer) by using the LSC spectrometer to obtain 85Sr recovery. It was found that when using a calibration curve comprised of a different cocktail and a non-optimum discriminator setting reasonable results (bias of « 25%) were achieved. The results from spiked samples containing 85Sr demonstrated that a higher recovery is obtained when using gamma spectroscopy (89-95%) than when using the LEB window

  8. Mapping and characterization of wheat stem rust resistance genes SrTm5 and Sr60 from Triticum monococcum.

    Science.gov (United States)

    Chen, Shisheng; Guo, Yan; Briggs, Jordan; Dubach, Felix; Chao, Shiaoman; Zhang, Wenjun; Rouse, Matthew N; Dubcovsky, Jorge

    2018-03-01

    The new stem rust resistance gene Sr60 was fine-mapped to the distal region of chromosome arm 5A m S, and the TTKSK-effective gene SrTm5 could be a new allele of Sr22. The emergence and spread of new virulent races of the wheat stem rust pathogen (Puccinia graminis f. sp. tritici; Pgt), including the Ug99 race group, is a serious threat to global wheat production. In this study, we mapped and characterized two stem rust resistance genes from diploid wheat Triticum monococcum accession PI 306540. We mapped SrTm5, a previously postulated gene effective to Ug99, on chromosome arm 7A m L, completely linked to Sr22. SrTm5 displayed a different race specificity compared to Sr22 indicating that they are distinct. Sequencing of the Sr22 homolog in PI 306540 revealed a novel haplotype. Characterization of the segregating populations with Pgt race QFCSC revealed an additional resistance gene on chromosome arm 5A m S that was assigned the official name Sr60. This gene was also effective against races QTHJC and SCCSC but not against TTKSK (a Ug99 group race). Using two large mapping populations (4046 gametes), we mapped Sr60 within a 0.44 cM interval flanked by sequenced-based markers GH724575 and CJ942731. These two markers delimit a 54.6-kb region in Brachypodium distachyon chromosome 4 and a 430-kb region in the Chinese Spring reference genome. Both regions include a leucine-rich repeat protein kinase (LRRK123.1) that represents a potential candidate gene. Three CC-NBS-LRR genes were found in the colinear Brachypodium region but not in the wheat genome. We are currently developing a Bacterial Artificial Chromosome library of PI 306540 to determine which of these candidate genes are present in the T. monococcum genome and to complete the cloning of Sr60.

  9. Transformation of Structure, Electrical Conductivity, and Magnetism in AA'Fe2O6-δ, A = Sr, Ca and A' = Sr.

    Science.gov (United States)

    Hona, Ram Krishna; Huq, Ashfia; Mulmi, Suresh; Ramezanipour, Farshid

    2017-08-21

    The ability to control electrical properties and magnetism by varying the crystal structure using the effect of the A-site cation in oxygen-deficient perovskites has been studied in AA'Fe 2 O 6-δ , where A = Sr, Ca and A' = Sr. The structure of Sr 2 Fe 2 O 6-δ , synthesized at 1250 °C in air, contains dimeric units of FeO 5 square pyramids separated by FeO 6 octahedra. Here we show that this ordering scheme can be transformed by changing the A-site cations from Sr to Ca. This leads to a structure where layers of corner-sharing FeO 6 octahedra are separated by chains of FeO 4 tetrahedra. Through systematic variation of the A-site cations, we have determined the average ionic radius required for this conversion to be ∼1.41 Å. We have demonstrated that the magnetic structure is also transformed. The Sr 2 compound has an incommensurate magnetic structure, where magnetic moments are in spin-density wave state, aligning perpendicular to the body diagonal of the unit cell. With the aid of neutron diffraction experiments at 10 and 300 K, we have shown that the magnetic structure is converted into a long-range G-type antiferromagnetic system when one Sr is replaced by Ca. In this G-type ordering scheme, the magnetic moments align in the 001 direction, antiparallel to their nearest neighbors. We have also performed variable-temperature electrical conductivity studies on these materials in the temperature range 298-1073 K. These studies have revealed the transformation of charge transport properties, where the metallic behavior of the Sr 2 compound is converted into semiconductivity in the CaSr material. The trend of conductivity as a function of temperature is reversed upon changing the A-site cation. The conductivity of the Sr 2 compound shows a downturn, while the conductivity of the CaSr material increases as a function of temperature. We have also shown that the CaSr compound exhibits temperature-dependent behavior typical of a mixed ionic-electronic conducting

  10. Biological response of Sr-containing coating with various surface treatments on titanium substrate for medical applications

    International Nuclear Information System (INIS)

    Yang, Shih-Ping; Lee, Tzer-Min; Lui, Truan-Sheng

    2015-01-01

    Graphical abstract: - Highlights: • Sr-containing coating prepared by plasma spraying and micro-arc oxidation process, respectively. • MAO coating stimulated high ECM-like structures of cells on early stage. • Sr-containing specimens had high cell responses on late stage. • Sr-MAO coating is a desirable implant surface treatment for clinical applications. - Abstract: An implant requires a suitable surface to trigger osteointegration. The surface characteristics and chemical composition are important factors in this process. Plasma spraying and micro-arc oxidation can be used to fabricate rough and porous structures for medical applications. Strontium (Sr) has been shown to prevent osteoporosis in vitro and in vivo. However, few scientists have evaluated the biological response of Sr-containing coatings on different surface treatments. In this study, a sand-blasted (SB) surface (as the control), plasma-sprayed hydroxyapatite (HA) and Sr-substituted HA coatings (HAPS and SrHAPS, respectively), calcium phosphate and Sr-containing calcium phosphate micro-arc oxidation surface (CPM and SrCPM, respectively) were analyzed in terms of human osteoblastic cell (MG63) response. Sr was confirmed to be incorporated into the surface. SrHAPS and SrCPM specimens had higher cell responses than those of the HAPS and CPM groups, respectively. The cells cultured on SrCPM and SrHAPS specimens exhibited high proliferation and differentiation. However, CPM and SrCPM specimens stimulated more ECM-like structures than other specimens. The results show that Sr-containing coatings have good characteristics that enhance cell response. The SrCPM coating is a suitable implant surface treatment for clinical applications

  11. Biological response of Sr-containing coating with various surface treatments on titanium substrate for medical applications

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Shih-Ping [Department of Materials Science and Engineering, National Cheng Kung University, Tainan, Taiwan (China); Lee, Tzer-Min, E-mail: tmlee@mail.ncku.edu.tw [Institute of Oral Medicine, National Cheng Kung University, Tainan, Taiwan (China); School of Dentistry, Kaohsiung Medical University, Kaohsiung, Taiwan (China); Lui, Truan-Sheng [Department of Materials Science and Engineering, National Cheng Kung University, Tainan, Taiwan (China)

    2015-08-15

    Graphical abstract: - Highlights: • Sr-containing coating prepared by plasma spraying and micro-arc oxidation process, respectively. • MAO coating stimulated high ECM-like structures of cells on early stage. • Sr-containing specimens had high cell responses on late stage. • Sr-MAO coating is a desirable implant surface treatment for clinical applications. - Abstract: An implant requires a suitable surface to trigger osteointegration. The surface characteristics and chemical composition are important factors in this process. Plasma spraying and micro-arc oxidation can be used to fabricate rough and porous structures for medical applications. Strontium (Sr) has been shown to prevent osteoporosis in vitro and in vivo. However, few scientists have evaluated the biological response of Sr-containing coatings on different surface treatments. In this study, a sand-blasted (SB) surface (as the control), plasma-sprayed hydroxyapatite (HA) and Sr-substituted HA coatings (HAPS and SrHAPS, respectively), calcium phosphate and Sr-containing calcium phosphate micro-arc oxidation surface (CPM and SrCPM, respectively) were analyzed in terms of human osteoblastic cell (MG63) response. Sr was confirmed to be incorporated into the surface. SrHAPS and SrCPM specimens had higher cell responses than those of the HAPS and CPM groups, respectively. The cells cultured on SrCPM and SrHAPS specimens exhibited high proliferation and differentiation. However, CPM and SrCPM specimens stimulated more ECM-like structures than other specimens. The results show that Sr-containing coatings have good characteristics that enhance cell response. The SrCPM coating is a suitable implant surface treatment for clinical applications.

  12. Introgression of stem rust resistance genes SrTA10187 and SrTA10171 from Aegilops tauschii to wheat.

    Science.gov (United States)

    Olson, Eric L; Rouse, Matthew N; Pumphrey, Michael O; Bowden, Robert L; Gill, Bikram S; Poland, Jesse A

    2013-10-01

    Aegilops tauschii, the diploid progenitor of the wheat D genome, is a readily accessible germplasm pool for wheat breeding as genes can be transferred to elite wheat cultivars through direct hybridization followed by backcrossing. Gene transfer and genetic mapping can be integrated by developing mapping populations during backcrossing. Using direct crossing, two genes for resistance to the African stem rust fungus race TTKSK (Ug99), were transferred from the Ae. tauschii accessions TA10187 and TA10171 to an elite hard winter wheat line, KS05HW14. BC2 mapping populations were created concurrently with developing advanced backcross lines carrying rust resistance. Bulked segregant analysis on the BC2 populations identified marker loci on 6DS and 7DS linked to stem rust resistance genes transferred from TA10187 and TA10171, respectively. Linkage maps were developed for both genes and closely linked markers reported in this study will be useful for selection and pyramiding with other Ug99-effective stem rust resistance genes. The Ae. tauschii-derived resistance genes were temporarily designated SrTA10187 and SrTA10171 and will serve as valuable resources for stem rust resistance breeding.

  13. Sr isotope tracing of multiple water sources in a complex river system, Noteć River, central Poland

    Energy Technology Data Exchange (ETDEWEB)

    Zieliński, Mateusz, E-mail: mateusz.zielinski@amu.edu.pl [Institute of Geoecology and Geoinformation, Adam Mickiewicz University, Dzięgielowa 27, 61-680 Poznań (Poland); Dopieralska, Jolanta, E-mail: dopieralska@amu.edu.pl [Poznań Science and Technology Park, Adam Mickiewicz University Foundation, Rubież 46, 61-612 Poznań (Poland); Belka, Zdzislaw, E-mail: zbelka@amu.edu.pl [Isotope Laboratory, Adam Mickiewicz University, Dzięgielowa 27, 61-680 Poznań (Poland); Walczak, Aleksandra, E-mail: awalczak@amu.edu.pl [Isotope Laboratory, Adam Mickiewicz University, Dzięgielowa 27, 61-680 Poznań (Poland); Siepak, Marcin, E-mail: siep@amu.edu.pl [Institute of Geology, Adam Mickiewicz University, Maków Polnych 16, 61-606 Poznań (Poland); Jakubowicz, Michal, E-mail: mjakub@amu.edu.pl [Institute of Geoecology and Geoinformation, Adam Mickiewicz University, Dzięgielowa 27, 61-680 Poznań (Poland)

    2016-04-01

    Anthropogenic impact on surface waters and other elements in the environment was investigated in the Noteć River basin in central Poland. The approach was to trace changes in the Sr isotope composition ({sup 87}Sr/{sup 86}Sr) and concentration in space and time. Systematic sampling of the river water shows a very wide range of {sup 87}Sr/{sup 86}Sr ratios, from 0.7089 to 0.7127. This strong variation, however, is restricted to the upper course of the river, whereas the water in the lower course typically shows {sup 87}Sr/{sup 86}Sr values around 0.7104–0.7105. Variations in {sup 87}Sr/{sup 86}Sr are associated with a wide range of Sr concentrations, from 0.14 to 1.32 mg/L. We find that strong variations in {sup 87}Sr/{sup 86}Sr and Sr concentrations can be accounted for by mixing of two end-members: 1) atmospheric waters charged with Sr from the near-surface weathering and wash-out of Quaternary glaciogenic deposits, and 2) waters introduced into the river from an open pit lignite mine. The first reservoir is characterized by a low Sr content and high {sup 87}Sr/{sup 86}Sr ratios, whereas mine waters display opposite characteristics. Anthropogenic pollution is also induced by extensive use of fertilizers which constitute the third source of Sr in the environment. The study has an important implication for future archeological studies in the region. It shows that the present-day Sr isotope signatures of river water, flora and fauna cannot be used unambiguously to determine the “baseline” for bioavailable {sup 87}Sr/{sup 86}Sr in the past. - Highlights: • Sr isotopes fingerprint water sources and their interactions in a complex river system. • Mine waters and fertilizers are critical anthropogenic additions in the river water. • Limited usage of environmental isotopic data in archeological studies. • Sr budget of the river is dynamic and temporary.

  14. Sorption of U(VI) in surfaces of SrTiO{sub 3}; Sorcion de U(VI) en superficies de SrTiO{sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Ortiz O, H.B.; Ordonez R, E.; Fernandez V, S.M. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    2004-07-01

    In this work is presented the physico chemical characterization and evaluation of those surface properties and of sorption of U on the SrTiO{sub 3} like possible candidate for contention barrier in the deep geological confinement. The made studies showed that the SrTiO{sub 3} presents maximum levels of sorption of positive nature species (mainly UO{sub 2}{sup 2+} and UO{sub 2}NO{sub 3}{sup +}). (Author)

  15. Assessing response of local moisture conditions in central Brazil to variability in regional monsoon intensity using speleothem 87Sr/86Sr values

    Science.gov (United States)

    Wortham, Barbara E.; Wong, Corinne I.; Silva, Lucas C. R.; McGee, David; Montañez, Isabel P.; Troy Rasbury, E.; Cooper, Kari M.; Sharp, Warren D.; Glessner, Justin J. G.; Santos, Roberto V.

    2017-04-01

    Delineating the controls on hydroclimate throughout Brazil is essential to assessing potential impact of global climate change on water resources and biogeography. An increasing number of monsoon reconstructions from δ18O records provide insight into variations in regional monsoon intensity over the last millennium. The strength, however, of δ18O as a proxy of regional climate limits its ability to reflect local conditions, highlighting the need for comparable reconstructions of local moisture conditions. Here, speleothem 87Sr/86Sr values are developed as a paleo-moisture proxy in central Brazil to complement existing δ18O-based reconstructions of regional monsoon intensity. Speleothem 87Sr/86Sr values are resolved using laser ablation and conventional solution mass spectrometry at high resolution relative to existing (non-δ18O-based) paleo-moisture reconstructions to allow comparisons of centennial variability in paleo-monsoon intensity and paleo-moisture conditions. Variations in speleothem 87Sr/86Sr values from Tamboril Cave are interpreted to reflect varying extents of water interaction with the carbonate host rock, with more interaction resulting in greater evolution of water isotope values from those initially acquired from the soil to those of the carbonate bedrock. Increasing speleothem 87Sr/86Sr values over the last millennium suggest progressively less interaction with the carbonate host rock likely resulting from higher infiltration rates, expected under wetter conditions. Increasingly wetter conditions over the last millennium are consistent with an overall trend of increasing monsoon intensity (decreasing δ18O values) preserved in many existing δ18O records from the region. Such a trend, however, is absent in δ18O records from our site (central Brazil) and Cristal Cave (southeast Brazil), suggesting the existence of divergent (relevant to δ18Oprecip) shifts in the climate patterns within and outside the core monsoon region.

  16. Solidification of Bi2Sr2Ca1Cu2Oy and Bi2Sr1.75Ca0.25CuOy

    International Nuclear Information System (INIS)

    Holesinger, T.G.; Miller, D.J.; Viswanathan, H.K.; Chumbley, L.S.

    1993-01-01

    The solidification processes for the compositions Bi 2 Sr 2 CaCu 2 O y (2212) and Bi 2 Sr 1.75 Ca 0.25 CuO y (2201) were determined as a function of oxygen partial pressure. During solidification in argon, the superconducting phases were generally not observed to form for either composition. In both cases, the solidus is lowered to approximately 750 degree C. Solidification of Bi 2 Sr 1.75 Ca 0.25 CuO y in Ar resulted in a divorced eutectic structure of Bi 2 Sr 2-x Ca x O y (22x) and Cu 2 O while solidification of Bi 2 Sr 2 CaCu 2 O y in Ar resulted in a divorced eutectic structure of Bi 2 Sr 3-x Ca x O y (23x) and Cu 2 O. Solidification of Bi 2 Sr 1.75 Ca 0.25 CuO y in O 2 resulted in large grains of 2201 interspersed with small regions containing the eutectic structure of 22x and CuO/Cu 2 O. Solidification of Bi 2 Sr 2 CaCu 2 O y in partial pressures of 1%, 20%, and 100% oxygen resulted in multiphase samples consisting of 2212, 2201, some alkaline-earth cuprates, and both divorced eutectic structures found during solidification in Ar. For both compositions, these latter structures can be attributed to oxygen deficiencies present in the melt regardless of the overpressure of oxygen. These eutectic structures are unstable and convert into the superconducting phases during subsequent anneals in oxygen. The formation process of the 2212 phase during solidification from the melt was determined to proceed through an intermediate state involving the 2201 phase

  17. Planning report for the safety assessment SR-Can

    International Nuclear Information System (INIS)

    2003-06-01

    This document is a planning report for SKB's next assessment of long-term safety for a KBS 3 repository. The assessment, SR-Can, is to be finished by the end of 2005 and will be used for SKB's application to build an Encapsulation plant for spent nuclear fuel. Apart from outlining the methodology, the report discusses the handling in SR-Can of a number of important issues regarding the near field, the geosphere, the biosphere, the climatic evolution etc. The Swedish nuclear safety and radiation protection authorities have recently issued regulations concerning the final disposal of nuclear waste. The principal compliance criterion states that the annual risk of harmful effects must not exceed 10 -6 for a representative individual in the group exposed to the greatest risk. There are also a number of requirements on methodological aspects of the safety assessment as well as on the contents of a safety report. The regulations are reproduced in an Appendix to this report. The primary safety function of the KBS 3 system is to completely isolate the spent nuclear fuel within copper canisters over the entire assessment period, which will be one million years in SR-Can. Should a canister be damaged, the secondary safety function is to retard any releases from the canisters. The main steps of the assessment are the following: 1. Qualitative system description, FEP processing: This step consists of defining a system boundary and of describing the system on a format suitable for the safety assessment. Databases of relevant features, events and processes influencing long-term safety are structured and used as one starting point for the assessment. 2. Initial state descriptions. 3. Process descriptions: In this step all identified processes within the system boundary involved in the long-term evolution of the system are described in detail. 4. Description of boundary conditions: This step is a broad description of the evolution of the boundaries of the system, focussing mainly

  18. Toxicity of inhaled 90SrCl2 in Beagle dogs. XIII

    International Nuclear Information System (INIS)

    Muggenburg, B.A.; Hahn, F.F.; Boecker, B.B.; Jones, R.K.; McClellan, R.O.; Pickrell, J.A.

    1979-01-01

    The metabolism, dosimetry and biological effects of inhaled 90 SrCl 2 in the Beagle dog are being studied to provide a basis for assessing the consequences of inhaling 90 Sr such as might be released in certain nuclear accidents. Seventy-two dogs were exposed to aerosols containing 90 Sr resulting in initial body burdens ranging from 2.5 to 250 μCi 90 Sr/kg body weight. To date, 60 90 Sr-exposed dogs have died or have been euthanized, six during the first 31 days after inhalation of 90 Sr with bone marrow aplasia and 54 between 585 and 5109 days after inhalation of 90 Sr. The latter group includes 32 dogs with bone-related neoplasms, two with upper respiratory tract carcinomas and five dogs with various diseases of the lower respiratory tract and heart. The other 15 dogs and diseases in organs that received little or no radiation dose, such as the gastrointestinal tract, urinary tract and the central nervous system. The skeletons of the dogs dying with bone-related neoplasms received initial radiation dose rates of 3.2 to 55 rads/day and cumulative doses to death of 2800 to 22 000 rads. Fourteen control dogs have died or been euthanized, two during the last year with mammary carcinoma and intestinal lymphosarcoma. Serial observations are continuing on the six surviving 90 Sr dogs and six controls

  19. Sr isotope ratio in the rainwater from Ahmedabad, an urban site in India

    International Nuclear Information System (INIS)

    Chatterjee, Jayati; Singh, Sunil K.

    2011-01-01

    The rain water Sr was measured at Ahmedabad to get an idea about the various sources of dissolved ions to rain water. The present study shows the Deccan trap as an important source of Sr during the south west monsoon. Occasional contributions from other lithologies such as alluvium of the Ganga system have also been observed during this study

  20. Promoting Photocatalytic Overall Water Splitting by Controlled Magnesium Incorporation in SrTiO3 Photocatalysts

    NARCIS (Netherlands)

    Han, Kai; Lin, Yen Chun; Yang, Chia Min; Jong, Ronald; Mul, Guido; Mei, Bastian

    2017-01-01

    SrTiO3 is a well-known photocatalyst inducing overall water splitting when exposed to UV irradiation of wavelengths <370 nm. However, the apparent quantum efficiency of SrTiO3 is typically low, even when functionalized with nanoparticles of Pt or Ni@NiO. Here, we introduce a simple solid-state

  1. Crystal structure and energy band and optical properties of phosphate Sr3P4O13

    International Nuclear Information System (INIS)

    Zhang, Y.-C.; Cheng, W.-D.; Wu, D.-S.; Zhang, H.; Chen, D.-G.; Gong, Y.-J.; Kan, Z.-G.

    2004-01-01

    A single crystal of the compound Sr 3 P 4 O 13 has been found and the crystal structure has been characterized by means of single crystal X-ray diffraction analysis. The compound crystallizes in triclinic system and belongs to space group P1-bar. It builds up from SrO 7 polyhedra and P 4 O 13 -6 anions and has a layered structure, and the Sr atoms are located in the interlayer space. The absorption and luminescence spectrum of Sr 3 P 4 O 13 microcrystals have been measured. The calculated results of crystal energy band structure by the DFT show that the solid state of Sr 3 P 4 O 13 is an isolator with direct band gap. The calculated total and partial density of states indicate that the top valence bands are contributions from P 3p and O 2p states and low conduction bands mostly originate from Sr atomic states. The calculated optical response functions expect that the Sr 3 P 4 O 13 is a low refractive index, and it is possible that the Sr 3 P 4 O 13 is used to make transparent material between the UV and FR light zone

  2. Synthesis and magnetic characterization of Sr-based Ni{sub 2}X-type hexaferrite

    Energy Technology Data Exchange (ETDEWEB)

    Kamishima, K., E-mail: kamisima@fms.saitama-u.ac.jp; Mashiko, T.; Kakizaki, K.; Sakai, M. [Graduate School of Science and Engineering, Saitama University, 255 Shimo-Okubo, Saitama 338-8570 (Japan); Watanabe, K. [Biomolecular Characterization Unit, Center of Sustainable Resource Science, RIKEN, 2-1 Wako, Saitama 351-0198 (Japan); Abe, H. [Advanced Electronic Materials Center, National Institute of Materials Science, 1-1 Namiki, Tsukuba 305-0044 (Japan)

    2015-10-15

    We have investigated the synthesis conditions, and the magnetic properties of the Sr{sub 2}Ni{sub 2}X-type hexagonal ferrite, Sr{sub 2}Ni{sub 2}Fe{sub 28}O{sub 46}. The Sr{sub 2}Ni{sub 2}X-type hexaferrite was synthesized at 1240{sup ∘}C. The spontaneous magnetization at 5 K was 44.2 μ{sub B}/f.u., suggesting that most of the Ni{sup 2+} ions are at the up-spin octahedral sites in the spinel-structure blocks within the model of a Néel-type collinear ferrimagnetic structure. The Curie temperature of the Sr{sub 2}Ni{sub 2}X-type hexaferrite was estimated to be T{sub C}[Sr{sub 2}Ni{sub 2}X] = 472{sup ∘}C. This is consistent with the difference of the block stacking structures of SrM-type, Sr{sub 2}Ni{sub 2}X-type, SrNi{sub 2}W-type, and nickel spinel ferrites.

  3. SR-BI: Linking Cholesterol and Lipoprotein Metabolism with Breast and Prostate Cancer

    Directory of Open Access Journals (Sweden)

    Jorge L. Gutierrez-Pajares

    2016-10-01

    Full Text Available Studies have demonstrated the significant role of cholesterol and lipoprotein metabolism in the progression of cancer. The SCARB1 gene encodes the scavenger receptor class B type I (SR-BI, which is an 82-kDa glycoprotein with two transmembrane domains separated by a large extracellular loop. SR-BI plays an important role in the regulation of cholesterol exchange between cells and high-density lipoproteins. Accordingly, hepatic SR-BI has been shown to play an essential role in the regulation of the reverse cholesterol transport pathway, which promotes the removal and excretion of excess body cholesterol. In the context of atherosclerosis, SR-BI has been implicated in the regulation of intracellular signaling, lipid accumulation, foam cell formation, and cellular apoptosis. Furthermore, since lipid metabolism is a relevant target for cancer treatment, recent studies have focused on examining the role of SR-BI in this pathology. While signaling pathways have initially been explored in non-tumoral cells, studies with cancer cells have now demonstrated SR-BI’s function in tumor progression. In this review, we will discuss the role of SR-BI during tumor development and malignant progression. In addition, we will provide insights into the transcriptional and post-transcriptional regulation of the SCARB1 gene. Overall, studying the role of SR-BI in tumor development and progression should allow us to gain useful information for the development of new therapeutic strategies.

  4. Comparison of histomorphometry and 85Sr uptake in induced heterotopic bone in rats

    DEFF Research Database (Denmark)

    Solheim, E; Pinholt, E M; Bang, G

    1992-01-01

    Heterotopic bone formation in the abdominal muscle of 45 male 8-week-old Wistar rats induced by implantation of 5, 10, or 15 mg demineralized bone (DBM) powder was evaluated at 4 weeks by 85Sr uptake of the implants and area histomorphometry of the induced bone. Two indices of 85Sr uptake were ca...

  5. Study on electrical properties of Ni-doped SrTiO3 ceramics using ...

    Indian Academy of Sciences (India)

    Unknown

    Ni doped SrTiO3; impedance spectroscopy; grain; grain boundary; acceptor. 1. Introduction. In commercial multilayer ceramic capacitors (MLCs), perovskite structure titanate are frequently used as high permittivity dielectrics. Alkaline earth titanates like BaTiO3,. SrTiO3 etc are widely used in microelectronic devices.

  6. The ternary post-transition metal carbodiimide SrZn(NCN){sub 2}

    Energy Technology Data Exchange (ETDEWEB)

    Corkett, Alex J.; Konze, Philipp M. [Institute of Inorganic Chemistry, RWTH Aachen University, Aachen (Germany); Dronskowski, Richard [Institute of Inorganic Chemistry, RWTH Aachen University, Aachen (Germany); Juelich-Aachen Research Alliance (JARA-HPC), RWTH-Aachen University, Aachen (Germany)

    2017-11-17

    SrZn(NCN){sub 2}, the first example of a ternary post-transition metal carbodiimide, was prepared by a solid-state metathesis reaction. The crystal structure was solved from PXRD data and found to adopt the orthorhombic (Cmcm) BaZnSO structure, a high symmetry modification of that expressed by the oxide analogue SrZnO{sub 2}. Locally, SrZn(NCN){sub 2} features ZnN{sub 4} tetrahedra and SrN{sub 6} trigonal prisms similar to those in quarternary LiSr{sub 2}M(NCN){sub 4} (M = Al{sup 3+} and Ga{sup 3+}) phases, however, the overall topologies are distinct with single chains in the former and double chains in the latter. Electronic structure calculations indicate an indirect bandgap of about 2.95 eV in SrZn(NCN){sub 2}, slightly lower than the experimentally observed bandgap of 3.4 eV in SrZnO{sub 2} and consistent with a greater degree of covalency. The structural similarities between SrZn(NCN){sub 2} and oxychalcogenide analogues highlight the pseudochalcogenide character of NCN{sup 2-} and suggest that the title compound may serve as a template for accessing novel ternary carbodiimides featuring tetrahedrally coordinated transition metals. (copyright 2017 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  7. Epitaxial growth of solution deposited Bi2Sr2CaCu2Ox films

    NARCIS (Netherlands)

    Gobel, OF; Du, [No Value; Hibma, T; von Lampe, [No Value; Steiner, U

    The epitaxial growth of Bi2Sr2CaCu2Ox (Bi2212) high temperature superconducting thin films was studied. The films were solution-deposited from a polymer-containing precursor onto SrTiO3 (001) substrates. Bi2212 formed an epitaxial phase with the c-axis parallel to the substrate normal and an in-lane

  8. A solidification model for unmodified, Na-modified and Sr-modified Al-Si alloys

    DEFF Research Database (Denmark)

    Tiedje, Niels Skat; Hattel, Jesper Henri; Taylor, J. A.

    2012-01-01

    An addition of small amounts of Na and Sr is commonly used in the industry to modify the eutectic in Al-Si alloys. Both Na and Sr suppress nucleation of the eutectic forcing nucleation and growth to take place at higher undercooling than in the unmodified material. Thus the scale of the eutectic ...

  9. Characterization of stem rust resistance gene Sr2 in Indian wheat ...

    African Journals Online (AJOL)

    SONY

    2013-05-01

    May 1, 2013 ... accelerating wheat production in the last forty years and ensured food security of the Nation. In the present investigation, Sr2 specific molecular markers were used to assess their efficacy for assessing the deployment of Sr2 gene in Indian wheat cultivars of highly productive north-west plains and stem rust ...

  10. Photocatalytic reduction synthesis of SrTiO3-graphene nanocomposites and their enhanced photocatalytic activity.

    Science.gov (United States)

    Xian, Tao; Yang, Hua; Di, Lijing; Ma, Jinyuan; Zhang, Haimin; Dai, Jianfeng

    2014-01-01

    SrTiO3-graphene nanocomposites were prepared via photocatalytic reduction of graphene oxide by UV light-irradiated SrTiO3 nanoparticles. Fourier transformed infrared spectroscopy analysis indicates that graphene oxide is reduced into graphene. Transmission electron microscope observation shows that SrTiO3 nanoparticles are well assembled onto graphene sheets. The photocatalytic activity of as-prepared SrTiO3-graphene composites was evaluated by the degradation of acid orange 7 (AO7) under a 254-nm UV irradiation, revealing that the composites exhibit significantly enhanced photocatalytic activity compared to the bare SrTiO3 nanoparticles. This can be explained by the fact that photogenerated electrons are captured by graphene, leading to an increased separation and availability of electrons and holes for the photocatalytic reaction. Hydroxyl (·OH) radicals were detected by the photoluminescence technique using terephthalic acid as a probe molecule and were found to be produced over the irradiated SrTiO3 nanoparticles and SrTiO3-graphene composites; especially, an enhanced yield is observed for the latter. The influence of ethanol, KI, and N2 on the photocatalytic efficiency was also investigated. Based on the experimental results, ·OH, h(+), and H2O2 are suggested to be the main active species in the photocatalytic degradation of AO7 by SrTiO3-graphene composites. 61.46. + w; 78.67.Bf; 78.66.Sq.

  11. Resistance switching at the interface of LaAlO3/SrTiO3

    DEFF Research Database (Denmark)

    Chen, Yunzhong; Zhao, J.L.; Sun, J.R.

    2010-01-01

    behavior is suggested to be an intrinsic feature of the SrTiO3 single crystal substrates, which mainly originates from the modulation of oxygen ion transfer in SrTiO3 surface by external electric field in the vicinity of interface, whereas the LaAlO3 film acts as a barrier layer. © 2010 American Institute...

  12. Determination methods of the 90Sr in a sample of contaminated water

    International Nuclear Information System (INIS)

    Ometakova, J.; Silvia Dulanska, S.

    2009-01-01

    The aim of this work was a comparison of selected products from the point of view of the amount of strontium yields, time needed and possibility of multiple use of sorbents. Three commercial products: 3M Empore Stroncium Rad Disk, AnaLig , Sr-Resin and two classical methods: liquid-liquid extraction with tributylphosphate and carbonate coprecipitation (to eliminate interferents) were used for separation of 90 Sr. The model sample was used in radiochemical analysis to check multiple use of 3M Em-pore Stroncium Rad Disk a AnaLig. A radiochemical strontium yield was traced by using radionuclide 85 Sr. The model sample was also used to optimize conditions of strontium separation. The results were used for 90 Sr determination from a sample of permeating groundwater from a supervised zone of a Nuclear Power Plant Jaslovske Bohunice. We have found out that 90 Sr separation with sorbents AnaLig Sr-01, 3M Empore Sr Rad Disk is as effective as with sorbent Sr-Resin in matrices of contaminated water. (authors)

  13. Interindividual variability and ontogenetic effects on Mg and Sr incorporation in the planktonic foraminifer Globigerinoides sacculifer

    NARCIS (Netherlands)

    Duenas-Bohorquez, A.; Da Rocha, R.E.; Kuroyanagi, A.; Nooijer, L.J. de; Bijma, J.; Reichart, G.-J.

    2011-01-01

    In order to investigate the interindividual and ontogenetic effects on Mg and Sr incorporation, magnesium/calcium (Mg/Ca) and strontium/calcium (Sr/Ca) ratios of cultured planktonic foraminifera have been determined. Specimens of Globigerinoides sacculifer were grown under controlled physical and

  14. Fuel and canister process report for the safety assessment SR-Site

    Energy Technology Data Exchange (ETDEWEB)

    Werme, Lars; Lilja, Christina (eds.)

    2010-12-15

    This report documents fuel and canister processes identified as relevant to the long-term safety of a KBS-3 repository. It forms an important part of the reporting of the safety assessment SR-Site. The detailed assessment methodology, including the role of the process reports in the assessment, is described in the SR-Site Main report /SKB 2011/

  15. 90Sr and 137Cs determination in milk and foodstuff samples in North and Middle Moravia

    International Nuclear Information System (INIS)

    Bartuskova, M.; Lusnak, J.; Rada, J.; Beckova, V.

    2008-01-01

    Activities of radionuclides Sr-90 and Cs-137 in milk and parts of foodstuff have been determined in National Radiation Protection Institute for many years. Sr-90 activity in those samples determinate branch Ostrava by radiochemical procedure - precipitation with oxalic acid and measuring with using gas-flow proportional detector. Gamma spectrometry with HPGe detector is using for 137 Cs determination. (authors)

  16. Fuel and canister process report for the safety assessment SR-Site

    International Nuclear Information System (INIS)

    Werme, Lars; Lilja, Christina

    2010-12-01

    This report documents fuel and canister processes identified as relevant to the long-term safety of a KBS-3 repository. It forms an important part of the reporting of the safety assessment SR-Site. The detailed assessment methodology, including the role of the process reports in the assessment, is described in the SR-Site Main report /SKB 2011/

  17. Loss ofAvrSr50by somatic exchange in stem rust leads to virulence forSr50resistance in wheat.

    Science.gov (United States)

    Chen, Jiapeng; Upadhyaya, Narayana M; Ortiz, Diana; Sperschneider, Jana; Li, Feng; Bouton, Clement; Breen, Susan; Dong, Chongmei; Xu, Bo; Zhang, Xiaoxiao; Mago, Rohit; Newell, Kim; Xia, Xiaodi; Bernoux, Maud; Taylor, Jennifer M; Steffenson, Brian; Jin, Yue; Zhang, Peng; Kanyuka, Kostya; Figueroa, Melania; Ellis, Jeffrey G; Park, Robert F; Dodds, Peter N

    2017-12-22

    Race-specific resistance genes protect the global wheat crop from stem rust disease caused by Puccinia graminis f. sp. tritici ( Pgt ) but are often overcome owing to evolution of new virulent races of the pathogen. To understand virulence evolution in Pgt , we identified the protein ligand (AvrSr50) recognized by the Sr50 resistance protein. A spontaneous mutant of Pgt virulent to Sr50 contained a 2.5 mega-base pair loss-of-heterozygosity event. A haustorial secreted protein from this region triggers Sr50 -dependent defense responses in planta and interacts directly with the Sr50 protein. Virulence alleles of AvrSr50 have arisen through DNA insertion and sequence divergence, and our data provide molecular evidence that in addition to sexual recombination, somatic exchange can play a role in the emergence of new virulence traits in Pgt . Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

  18. Energy transfer in Pr3+ and Mn2+ co-doped SrB6O10 and SrB4O7

    International Nuclear Information System (INIS)

    Chen Yonghu; Yan Wuzhao; Shi Chaoshu

    2007-01-01

    The luminescent properties of Pr 3+ and Mn 2+ -doped SrB 6 O 10 and SrB 4 O 7 powder samples were investigated from the point of view of energy transfer between Pr 3+ and Mn 2+ . The emission from the 1 S 0 level of Pr 3+ was found in the SrB 6 O 10 :Pr 3+ sample as well as in the SrB 4 O 7 :Pr 3+ sample, indicating the 1 S 0 level is below the lowest 4f5d energy level in these hosts. The spectral overlaps between the emission spectra of Pr 3+ -doped samples and the excitation spectra of Mn 2+ -doped sample were found in both kinds of strontium borates. These spectral overlaps are in favor of the energy transfer from Pr 3+ to Mn 2+ . However, in the emission spectra of the SrB 6 O 10 :Pr 3+ , Mn 2+ , no indication of energy transfer was observed, though the emission spectra of SrB 4 O 7 :Pr 3+ , Mn 2+ did show evidence of energy transfer from Pr 3+ to Mn 2+ . The possible reasons were discussed

  19. Ab initio investigations of the strontium gallium nitride ternaries Sr 3GaN3 and Sr6GaN5: Promising materials for optoelectronic

    KAUST Repository

    Goumri-Said, Souraya

    2013-05-31

    Sr3GaN3 and Sr6GaN5 could be promising potential materials for applications in the microelectronics, optoelectronics and coating materials areas of research. We studied in detail their structural, elastic, electronic, optical as well as the vibrational properties, by means of density functional theory framework. Both of these ternaries are semiconductors, where Sr3GaN3 exhibits a small indirect gap whereas Sr6GaN5 has a large direct gap. Indeed, their optical properties are reported for radiation up to 40 eV. Charge densities contours, Hirshfeld and Mulliken populations, are reported to investigate the role of each element in the bonding. From the mechanical properties calculation, it is found that Sr6GaN5 is harder than Sr3GaN3, and the latter is more anisotropic than the former. The phonon dispersion relation, density of phonon states and the vibrational stability are reported from the density functional perturbation theory calculations. © 2013 IOP Publishing Ltd.

  20. Coexistence of spin frozen state and persistent spin dynamics in NaSrCo{sub 2}F{sub 7} as probed by μSR and NMR

    Energy Technology Data Exchange (ETDEWEB)

    Dengre, Shanu; Sarkar, Rajib; Braeuninger, Sascha Albert; Brueckner, Felix; Materne, Philipp; Klauss, Hans-Henning [Institute for Solid State Physics, TU Dresden (Germany); Krizan, Jason W.; Cava, Robert J. [Department of Chemistry, Princeton University, Princeton, NJ (United States); Luetkens, Hubertus; Baines, Chris [Laboratory for Muon-Spin Spectroscopy, Paul Scherrer Institute, Villigen (Switzerland)

    2016-07-01

    {sup 23}Na -and {sup 19}F NMR, and μSR experiments are performed to explore the microscopic properties of NaSrCo{sub 2}F{sub 7}, which is a newly discovered magnetically frustrated pyrochlore with weak bond disorder and with a frustration index of f = 42. While {sup 23}Na and {sup 19}F NMR experiments clearly suggest the presence of quasi static field distribution below ∝3 K as reflected in the huge NMR line broadening and wipe out effect of NMR signal intensity, μSR experiments on the other hand remains passive to this spin frozen state. Both NMR and μSR results indicate the slowing down of the magnetic (spin) fluctuations upon cooling towards the NMR spin frozen state. μSR relaxation rate increases slightly below ∝ 3 K, and remains not only constant down to 20 mK, but also stands independent in longitudinal magnetic field upto 4000 G implying that the spin fluctuations are dynamic. These observations suggest the coexistence of partial spin frozen state and persistent spin dynamics in NaSrCo{sub 2}F{sub 7}.

  1. Evaluation of mobility potential of 90Sr in Brazilian soils

    International Nuclear Information System (INIS)

    Viana, Aline Gonzalez

    2007-01-01

    In this document, the transfer mechanisms of 90 Sr were studied in soil-plant systems from Brazil, integrating field and laboratory experiments. Some soil classes, with different physical and chemical properties, relevant to Brazil were selected. The soil classes included in this study were Oxisol, Alfisol and Nitisol. These soils were artificially contaminated with 90 Sr for crop cultivation in lysimeters located at the experimental area of the Instituto de Radioprotecao e Dosimetria. The selected crops chosen to the root uptake studies were: corn (Zea mays, L.), cabbage (Brassica oleracea) and radish (Raphanus sativus L.). These cultures were chosen because they have varying absorption rates due to differences in the physiologic structures analyzed: grain, leaf and root. This study identified Nitisol, which contains clay of high activity, as having smaller transfer factor for all crops and these values were in the same order of magnitude as temperate climate values reported in the specialized literature: FT corn : 5,78E-3 (n=2); FT radish : 1,78 E0 (n=2); FT cabbage : 9,16E-1 (n=2). All other soils presented higher TF values, ranging from 1,93E0 to 4,06 E + 01 for radish (n=8), from 9,99 E-2 to 8,80 E0 for cabbage (n=16) and from 9,94 E-3 to 1,60 E-2 for corn (n=14). It was verified that the TF values for corn presented a significant linear correlation with the following properties of the soils: exchangeable Ca and Mg, Cation Exchange Capacity and Organic matter content (p=99,9%), corroborating the behavior described in the related literature. The TF values for cabbage presented significant correlation with exchangeable Ca and pH (p=99,9%), while no correlation between TF and soil properties where observed for radish. The results of sequential extraction evidenced the great 90 Sr availability for transfer in the soil-plant system; nevertheless, physiological processes occurring in such unfertile soils (low CEC, low pH and low OM and nutrients content) improved

  2. Nonstoichiometry and stability in water of undoped SrCeO3

    Directory of Open Access Journals (Sweden)

    Jurado, J. R.

    2003-10-01

    Full Text Available Strontium cerate is the parent phase of an important class of proton-conducting perovskites with various potential technological applications. Phase formation and structure of SrCeO3 with Sr:Ce nonstoichiometry have been investigated for the series, Sr1±xCeO3±δ (0.98 ≤ x ≤ 1.04. Analyses by EPMA (electron probe micro analysis and X-ray diffraction (XRD indicate that, for samples sintered at 1350°C, the main phase is Sr-rich for all x. The accommodation of excess SrO in the bulk phase and/or intergranular regions is discussed. The stability of nominally stoichiometric SrCeO3 was examined in an atmosphere of high water vapour partial pressure (pH2O for 2 hours, degrading to Sr(OH2.H2O and CeO2 for pH2O ≥ 3.6atm.La fase SrCeO3 da origen a una importante familia de perovskitas conductoras protónicas con potenciales aplicaciones tecnológicas. En este trabajo se estudia la formación de la fase y la estructura de SrCeO3 con la relación Sr:Ce no estequiométrica para la serie Sr1±xCeO3±δ (0.98 ≤ x ≤ 1.04. Los análisis por microsonda (EPMA y difracción de rayos X (DRX indican que en las muestras sinterizadas a 1350°C, la fase principal es rica en estroncio para todo valor de x. Se discute la posible ubicación del exceso de SrO tanto en la región intergranular como en el propio grano. También se examina la estabilidad de la composición con estequiometría nominal SrCeO3 en una atmosfera con una alta presión de vapor de agua (pH2O, observándose que la degradación a Sr(OH2.H2O y CeO2 ocurre a pH2O ≥ 3.6atm (expuesto durante 2 horas.

  3. Strain Induced Magnetism in SrRuO3 Epitaxial Thin Films

    Energy Technology Data Exchange (ETDEWEB)

    Grutter, A.; Wong, F.; Arenholz, E.; Liberati, M.; Suzuki, Y.

    2010-01-10

    Epitaxial SrRuO{sub 3} thin films were grown on SrTiO{sub 3}, (LaAlO{sub 3}){sub 0.3}(SrAlO{sub 3}){sub 0.7} and LaAlO{sub 3} substrates inducing different biaxial compressive strains. Coherently strained SrRuO{sub 3} films exhibit enhanced magnetization compared to previously reported bulk and thin film values of 1.1-1.6 {micro}{sub B} per formula unit. A comparison of (001) and (110) SrRuO{sub 3} films on each substrate indicates that films on (110) oriented have consistently higher saturated moments than corresponding (001) films. These observations indicate the importance of lattice distortions in controlling the magnetic ground state in this transitional metal oxide.

  4. Effect of Sr Additive Amount and Holding Time on Microstructure of A390 Aluminum Alloy

    Science.gov (United States)

    Zhang, J. H.; Xing, S. M.; Han, Q. Y.; Guo, Q.; Wang, R. F.

    2017-11-01

    The microstructure of A390 alloy under different Sr additive amounts and holding times was studied by means of direct reading spectrum analysis, energy spectrum analysis, optical microscope and electron microscope. The results show that Sr has a good modification to eutectic Si, while it has a negative effect on primary silicon. The Sr addition will increase the size of primary silicon. When the addition amount of Al-10Sr alloy is 0.6%, the modification of eutectic silicon is the optimum. The Sr has a short incubation period and a fine modification at 10min, but it is more serious burning rate in small furnace smelting, and the modification effect disappears basically after 100min.

  5. Synthesis and Photoluminescent Properties of Li2SrSiO4:Pb2+

    Science.gov (United States)

    Erdoğmuş, E.; Pekgözlü, I.; Korkmaz, E.; Başak, A. S.

    2014-05-01

    Pure and Pb2+ doped Li2SrSiO4 materials were synthesized at 900°C for 12 h in air. The phases of the synthesized materials were determined by X-ray powder diffraction (XRD). The photoluminescence properties of the synthesized phosphors were investigated by spectrofl uorometry at room temperature. The emission and excitation bands of Li2SrSiO4:Pb2+ were observed at 381 and 271 nm, respectively. The dependence of the emission intensity on Pb2+ concentration for Li2Sr1-xPbxSiO4 was studied in detail. It was observed that the optimum concentration of Pb2+ in Li2SrSiO4 is 0.01 mol.%. The Stokes shifts of Li2SrSiO4:Pb2+ phosphor was calculated to be 10653 cm-1.

  6. Study of atomic and molecular emission spectra of Sr by laser induced breakdown spectroscopy (LIBS).

    Science.gov (United States)

    Bhatt, Chet R; Alfarraj, Bader; Ayyalasomayajula, Krishna K; Ghany, Charles; Yueh, Fang Y; Singh, Jagdish P

    2015-12-01

    Laser Induced Breakdown Spectroscopy (LIBS) is an ideal analytical technique for in situ analysis of elemental composition. We have performed a comparative study of the quantitative and qualitative analysis of atomic and molecular emission from LIBS spectra. In our experiments, a mixture of SrCl2 and Al2O3 in powder form was used as a sample. The atomic emission from Sr and molecular emission from SrCl and SrO observed in LIBS spectra were analyzed. The optimum laser energies, gate delays, and gate widths for selected atomic lines and molecular bands were determined from spectra recorded at various experimental parameters. These optimum experimental conditions were used to collect calibration data, and the calibration curves were used to predict the Sr concentration. Limits of detection (LODs) for selected atomic and molecular emission spectra were determined.

  7. Baseline concentrations of strontium and 90Sr in seawater from the northern Gulf

    International Nuclear Information System (INIS)

    Uddin, S.; Al Ghadban, A.N.; Behbahani, M.

    2013-01-01

    Highlights: • This is the first baseline for strontium and 90 Sr from northern Gulf. • The total strontium concentration is much higher than reported for other oceans. • The Sr/salinity ratio correlates well with global averages. • High Sr might be due to increased salinity/CaCo 3 dissolution in acidifying Gulf waters. -- Abstract: Baseline concentration of strontium and Sr-90 in Gulf is presented. The strontium concentration is much higher than reported for other oceanic waters, while the Sr-90 concentration is low at 0.7–1.0 mBq l −1 , that represents the background level following nuclear tests and can be used as an effective tracer in case of any radioactive release in the region. The strontium concentration is primarily related to the increasing salinity off the Gulf coast

  8. Resistance switching in epitaxial SrCoO{sub x} thin films

    Energy Technology Data Exchange (ETDEWEB)

    Tambunan, Octolia T.; Parwanta, Kadek J.; Acharya, Susant K.; Lee, Bo Wha; Jung, Chang Uk, E-mail: cu-jung@hufs.ac.kr [Department of Physics, Hankuk University of Foreign Studies, Yongin 449-791 (Korea, Republic of); Kim, Yeon Soo; Park, Bae Ho [Division of Quantum Phases and Devices, Department of Physics, Konkuk University, Seoul 143-791 (Korea, Republic of); Jeong, Huiseong; Park, Ji-Yong [Department of Physics and Division of Energy System Research, Ajou University, Suwon 443-749 (Korea, Republic of); Cho, Myung Rae; Park, Yun Daniel [Department of Physics and Astronomy and Center for Subwavelength Optics, Seoul National University, Seoul 151-747 (Korea, Republic of); Choi, Woo Seok [Department of Physics, Sungkyunkwan University, Suwon 440-746 (Korea, Republic of); Kim, Dong-Wook [Department of Physics, Ewha Womans University, Seoul 120-750 (Korea, Republic of); Jin, Hyunwoo; Lee, Suyoun [Electronic Materials Research Center, Korea Institute of Science and Technology, Seoul 136-791 (Korea, Republic of); Song, Seul Ji; Kang, Sung-Jin; Kim, Miyoung; Hwang, Cheol Seong [Department of Material Science and Engineering, Seoul National University, Seoul 151-747 (Korea, Republic of)

    2014-08-11

    We observed bipolar switching behavior from an epitaxial strontium cobaltite film grown on a SrTiO{sub 3} (001) substrate. The crystal structure of strontium cobaltite has been known to undergo topotactic phase transformation between two distinct phases: insulating brownmillerite (SrCoO{sub 2.5}) and conducting perovskite (SrCoO{sub 3−δ}) depending on the oxygen content. The current–voltage characteristics of the strontium cobaltite film showed that it could have a reversible insulator-to-metal transition triggered by electrical bias voltage. We propose that the resistance switching in the SrCoO{sub x} thin film could be related to the topotactic phase transformation and the peculiar structure of SrCoO{sub 2.5}.

  9. Self-organized Sr leads to solid state twinning in nano-scaled eutectic Si phase.

    Science.gov (United States)

    Albu, M; Pal, A; Gspan, C; Picu, R C; Hofer, F; Kothleitner, G

    2016-08-16

    A new mechanism for twin nucleation in the eutectic Al-Si alloy with trace Sr impurities is proposed. Observations made by sub-angstrom resolution scanning transmission electron microscopy and X-ray probing proved the presence of Sr columns located preferentially at twin boundaries. Density functional theory simulations indicate that Sr atoms bind in the Si lattice only along the direction, with preferential positions at first and second nearest neighbors for interstitial and substitutional Sr, respectively. Density functional theory total energy calculations confirm that twin nucleation at Sr columns is energetically favorable. Hence, twins may nucleate in Si precipitates after solidification, which provides a different perspective to the currently accepted mechanism which suggests twin formation during precipitate growth.

  10. Evaluating the therapeutic effect of 89Sr using Bremsstrahlung imaging in patients with bone metastases

    International Nuclear Information System (INIS)

    Zhang Daping; Lou Cen; Chen Liang; Yu Linliang; Huang Huacheng

    2003-01-01

    Objective: To evaluate the therapeutic effect of 89 Sr (a pure beta emitter) using Bremsstrahlung imaging in patients with multiple bone metastases. Methods: 89 Sr Bremsstrahlung imaging was performed 1-2 weeks after injection in 14 patients with bone metastases, using GE Camstar 3200 SPECT equipped with a medium-energy collimator. To improve resolution of imaging, authors selected suitable energy level and wide window width (a 95-100% energy window around 100 KeV). Results: Abnormal uptake was seen in all and was consistent with the results of 99m Tc-MDP imaging. According to this result, authors can realize localization, retention and metabolism of 89 Sr in body. Conclusion: Bremsstrahlung imaging is useful for clinical observation and estimating the curative effect and prognosis in pure beta emitter therapy such as 89 Sr. In addition, it can be helpful in determining dose of 89 Sr if a repeated therapy is needed

  11. Characterization of Donut-Like SrMoO4 Produced by Microwave-Hydrothermal Process

    Directory of Open Access Journals (Sweden)

    Surangkana Wannapop

    2013-01-01

    Full Text Available SrMoO4 hierarchical nanostructures were successfully produced by a one step of 270 W microwave-hydrothermal process of one of the solutions containing three strontium salts [Sr(NO32, Sr(CH3CO22, and SrCl2·6H2O] and (NH46Mo7O24·4H2O for different lengths of time. The as-produced products were characterized by X-ray diffraction, electron microscopy, and spectroscopy. In this research, they were primitive tetragonal structured donut-like SrMoO4, with the main 881 cm−1  ν1(Ag symmetric stretching vibration mode of [MoO4]2− units and 3.92 eV energy gap.

  12. The Structural Disorder and Lattice Stability of (Ba,Sr)(Co,Fe)O3 Complex Perovskites

    Energy Technology Data Exchange (ETDEWEB)

    S.N.Rashkeev

    2011-05-01

    The structural disorder and lattice stability of complex perovskite (Ba,Sr)(Co,Fe)O3, a promising cathode material for solid oxide fuel cells and oxygen permeation membranes, is explored by means of first principles DFT calculations. It is predicted that Ba and Sr ions easily exchange their lattice positions (A-cation disorder) similarly to Co and Fe ions (B-cation disorder). The cation antisite defects (exchange of A- and B-type cations) have a relatively high formation energy. The BSCF is predicted to exist in an equilibrium mixture of several phases and can decompose exothermically into the Ba- and Co-rich hexagonal (Ba,Sr)CoO3 and Sr- and Fe-rich cubic (Ba,Sr)FeO3 perovskites.

  13. Optical Properties of Rare Earth Doped SrS Phosphor: A Review

    Science.gov (United States)

    Khare, Ayush; Mishra, Shubhra; Kshatri, D. S.; Tiwari, Sanjay

    2017-02-01

    Rare earth (RE) doped SrS phosphor has attracted a lot of attention on a wide range of photo-, cathodo-, thermo-, and electroluminescent applications. Upon doping with different RE elements (e.g., Ce, Pr, Eu, Yb), the luminescence from SrS can be varied over the entire visible region by appropriately choosing the composition of the strontium sulfide host. The main applications include flat panel displays and SrS-based powder electroluminescence (EL) for back lights. Sulfide materials known for providing Eu2+ based red emission band and preferred as a color conversion material in white light emitting diodes are discussed. Especially, the applications of RE doped SrS are described in light of their utility as conversion and storage phosphors. The effect of energy level splitting, EL efficiency, post-annealing, milling time, and impurity on luminescence properties for SrS are also discussed.

  14. Effect of Sr doping on LaTiO3 thin films

    International Nuclear Information System (INIS)

    Vilquin, B.; Kanki, T.; Yanagida, T.; Tanaka, H.; Kawai, T.

    2005-01-01

    We report on the electric properties of La 1-x Sr x TiO 3 (0 ≤ x ≤ 0.5) thin films fabricated by pulsed laser deposition method. Crystallographic measurement of the thin films showed the epitaxial c-axis perovskite structure. The electric property of LaTiO 3 thin film, which is a typical Mott insulative material in bulk, showed insulative behaviour, while the Sr-doped films showed metallic conduction suffering electron-electron scattering. Below x = 0.1, the major carrier type was identified to be hole, and switched to electron with further increasing Sr-doping above x = 0.15. In fact, the switching from p-type to n-type for La 1-x Sr x TiO 3 thin films is first demonstrated in this study. The transition suggests that effective Coulomb gap vanishes due to over-additional Sr doping

  15. Evaluation of Adsorption Properties for Cs and Sr Selective Adsorbents-13171

    International Nuclear Information System (INIS)

    Nakai, Tomonori; Wakabayashi, Syunya; Mimura, Hitoshi; Niibori, Yuichi; Kurosaki, Fumio; Matsukura, Minoru; Tanigawa, Hiroshi; Ishizaki, Eiji

    2013-01-01

    The development of effective treatment and disposal methods is very urgent and important subject. Tohoku University and UNION SHOWA have developed various selective adsorbents (zeolites, zeolite sheets and composites loaded with insoluble ferrocyanides) for the effective decontamination of radioactive Cs + and Sr 2+ As for Cs + adsorption, CST, chabazite and insoluble ferrocyanides composites had relatively large distribution coefficients (K d ) above 10 3 cm 3 /g and excellent adsorption kinetics in seawater. Even after high temperature calcination at 1,100 deg. C, cesium was still immobilized in the calcined products of Cs + -zeolites, suggesting high immobilization ability of zeolites for Cs + . As for Sr 2+ adsorption, A and X zeolites had relatively large K d values around 10 2 cm 3 /g, and zeolite sheet (A zeolite) exhibited excellent adsorption kinetics in seawater. Considering the decontamination of radioactive Sr 2+ in groundwater, the effects of Ca 2+ and Mg 2+ ions on the K d value of Sr 2+ were further examined by batch method. The K d value of Sr 2+ was almost independent of Mg 2+ concentration up to 2,500 ppm, while gradually lowered in the presence of Ca 2+ above 200 ppm, due to the differences in the ionic radius of hydrated ion. The Cs + and Sr 2+ adsorption ability for KNiFC-A (composite of A zeolite loaded with insoluble ferrocyanides) was examined by batch method. Here the matrix of composite (A zeolite) and loaded ferrocyanides (KNiFC) have high selectivity towards Sr 2+ and Cs + , respectively. The K d values of Sr 2+ and Cs + in seawater were estimated to be above 10 2 and 10 3 cm 3 /g, respectively, indicating the effectiveness for the decontamination of both Sr 2+ and Cs + . The basic data on the Cs + and Sr 2+ adsorption properties for selective adsorbents are effective for the practical decontamination processes of these metal ions in seawater and groundwater. (authors)

  16. Toxicity of inhaled 90SrCl2 in beagle dogs. XI

    International Nuclear Information System (INIS)

    Muggenburg, B.A.; Rebar, A.H.; Benjamin, S.A.; Boecker, B.B.; Jones, R. K.; McClellan, R.O.; Pickrell, J.A.

    1977-01-01

    Studies on the metabolism, dosimetry, and effects of inhaled 90 SrCl 2 in the Beagle dog are continuing in an effort to provide a basis for assessing the consequences of inhaling 90 Sr such as might be released in certain nuclear accidents. Seventy-two dogs were exposed to aerosols containing 90 Sr resulting in initial body burdens ranging from 2.5 to 250 μCi 90 Sr/kg body weight. Forty-eight of these dogs are being maintained for lifetime observation. Twenty-five unexposed dogs serve as controls. The long-term retained burden (LTRB) in these dogs ranged from 1 to 120 μCi 90 Sr/kg. Twenty-four dogs with a mean LTRB of 38 μCi 90 Sr/kg have been assigned to a sacrifice study. Two of these dogs and one control dog were sacrificed at five days, one month and one year after inhalation of 90 Sr. To date, 51 90 Sr-exposed dogs have died or have been euthanized, six during the first 31 days after inhalation of 90 Sr with bone marrow aplasia and 45 between 585 and 4236 days after inhalation of 90 Sr. The latter group includes 12 dogs with bone-related hemangiosarcomas, 16 with osteosarcomas, three with fibrosarcomas, three with osteochondrosarcomas, one with osteochondrofibrosarcoma, two with leukemia, one with a baso-squamous carcinoma of the skull, one with a squamous cell carcinoma of the maxilla, one with a squamous cell carcinoma of the frontal sinus, one with a hemangiosarc