WorldWideScience

Sample records for international appeal rap

  1. The right to a fair appeal in international criminal law

    NARCIS (Netherlands)

    Djukic, Drazan

    2017-01-01

    The Right to a Fair Appeal in International Criminal Law – Layman’s Summary A criminal trial does not end after the first judgment of a court. A person is only finally found guilty or innocent after one or more appeals. Appeals thus have an important place in the criminal justice system. However,

  2. Feeling the Beat: The Meaning of Rap Music for Ethnically Diverse Midwestern College Students--A Phenomenological Study

    Science.gov (United States)

    Iwamoto, Derek K.; Creswell, John; Caldwell, Leon

    2007-01-01

    Despite its national and international appeal, rap is considered one of the most controversial of music genres. Given the political charge it generates, rap music has spawned research across the social and health sciences. The majority of the research has investigated its impact on African Americans. Further, the research has tended to focus on…

  3. Municipal Tender Awards and Internal Appeals by unsuccessful ...

    African Journals Online (AJOL)

    ... Regulations,2 enacted under the Local Government: Municipal Finance Management Act.3 It is argued that at present, internal appeal and dispute resolution processes do not afford unsuccessful bidders adequate protection. Keywords: Appeals; bid committee system; competitive bidding; Constitution; dispute resolution; ...

  4. Feeling the beat: the meaning of rap music for ethnically diverse Midwestern college students--a phenomenological study.

    Science.gov (United States)

    Iwamoto, Derek K; Creswell, John; Caldwell, Leon

    2007-01-01

    Despite its national and international appeal, rap is considered one of the most controversial of music genres. Given the political charge it generates, rap music has spawned research across the social and health sciences. The majority of the research has investigated its impact on African Americans. Further, the research has tended to focus on negative aspects of the music; there has been a dearth of in-depth qualitative studies that explore how rap impacts the listener. Our phenomenological study explores that impact on ethnically diverse college students. Results indicate a profound psychological and educational effect and the discussion goes on to highlight the potential and innovative ways rap music can be utilized with adolescents in fields such as education, risk reduction programs, and counseling psychology.

  5. The right to appeal on criminal procedure under international acts and jurisprudence

    Directory of Open Access Journals (Sweden)

    MSc. Vilard Bytyqi

    2016-01-01

    Full Text Available The right to appeal, respectively the right on complaint as per our legal vocabulary, constitutes the basic trunk of the second phase of court decisions in a certain procedure, in particular the criminal proceedings. The aim of this paper is to emphasize the main notions of appeal, but also in other aspects through the comparative description it aims to bring more clarity in differences and similarities that exist in between the appeal which is used in our criminal proceedings and the appeal which is used in the criminal proceedings that take place in the supranational courts. It is known that in courts which consist of international elements, the appeal is positioned in a more advanced level, due to the fact that there are grounds of suspicion used over every element that could be used in any national criminal proceedings. Overall, in any place of the world, the appeal has the goal to remedy court decisions brought by the court of first instance, while, in the procedural aspect it has more or less differences depending on the regulations of criminal procedures of that state.  Such difference due to the diversity of the legal systems today are also accepted as the universal legal value, since establishment of international tribunals provides the best practice in this field.

  6. Rap Poetry and Postmodernism

    Directory of Open Access Journals (Sweden)

    Kirill Molokov

    2017-10-01

    Full Text Available This article observes several most significant rap albums of this decade within postmodern literature. Today rap culture ceased to be a sort of “outsider” in academic opinion, because of its influences on the culture and art innovations. We study albums as literary objects according to literary aesthetic theories and principles, display the main postmodern features they have, and analyze the role of rap poetry within postmodernism in general. The results suggest that rap poetry is postmodern not only musically, but also lyrically, as an object of literature. The rap music embodies all the postmodern traits and synthesizes them within the syntheses of music and literature and high art and pop culture.

  7. Aesthetic Appeal

    DEFF Research Database (Denmark)

    Folkmann, Mads Nygaard

    2014-01-01

    of experience, e.g. in appeal to emotions or pleasure. 2) On a conceptual-hermeneutical level, the staging of meaning by design objects is in question. This regards, on the one hand, the appeal to understanding by the human subject and, on the other hand, the ability of the object to reflect its own character...... on three levels: 1) On a sensual-phenomenological level, the focus is on sensual appeal, i.e. how the design object by its sensual and tactile effects and its outer shape creates an appeal to human experience. This is not a matter of style but of the object relating to and framing the conditions......, the question of aesthetics in design may be answered by both addressing the internal meaning formulation of the aesthetic appeal and the external cultural and discursive framing of design that influences how design is perceived as ‘aesthetic’....

  8. 76 FR 44491 - Group Health Plans and Health Insurance Issuers: Rules Relating to Internal Claims and Appeals...

    Science.gov (United States)

    2011-07-26

    ... 37208) entitled, ``Group Health Plans and Health Insurance Issuers: Rules Relating to Internal Claims..., ``Group Health Plans and Health Insurance Issuers: Rules Relating to Internal Claims and Appeals and... external review processes for group health plans and health insurance issuers offering coverage in the...

  9. The Right to Appeal as a Fundamental Right under International Acts and Jurisprudence, with Special Emphasis on Criminal Procedure

    Directory of Open Access Journals (Sweden)

    Vilard BYTYQI

    2017-03-01

    Full Text Available The right to appeal, respectively the right on complaint as per our legal vocabulary, constitutes the basic trunk of the second phase of court decisions in a certain procedure, in particular the criminal proceedings. The aim of this paper is to emphasize the main notions of appeal, but also in other aspects through the comparative description it aims to bring more clarity in differences and similarities that exist in between the appeal which is used in our criminal proceedings and the appeal which is used in the criminal proceedings that take place in the supranational courts. It is known that in courts which consist of international elements, the appeal is positioned in a more advanced level, due to the fact that there are grounds of suspicion used over every element that could be used in any national criminal proceedings. Overall, in any place of the world, the appeal has the goal to remedy court decisions brought by the court of first instance, while, in the procedural aspect it has more or less differences depending on the regulations of criminal procedures of that state. Such difference due to the diversity of the legal systems today are also accepted as the universal legal value, since establishment of international tribunals provides the best practice in this field.

  10. Radiological Assistance Program (RAP) Regions

    Data.gov (United States)

    Department of Homeland Security — The U.S. Department of Energy (DOE) created the Radiological Assistance Program (RAP) in the 1950s to make DOE resources and expertise available to organizations...

  11. Rapid Refresh (RAP) [13 km

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Rapid Refresh (RAP) numerical weather model took the place of the Rapid Update Cycle (RUC) on May 1, 2012. Run by the National Centers for Environmental...

  12. Rapid Refresh (RAP) [20 km

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Rapid Refresh (RAP) numerical weather model took the place of the Rapid Update Cycle (RUC) on May 1, 2012. Run by the National Centers for Environmental...

  13. Remote Area Power Supply (RAPS) load and resource profiles.

    Energy Technology Data Exchange (ETDEWEB)

    Giles, Lauren (Energetics, Inc., Washington, DC); Skolnik, Edward G. (Energetics, Inc., Washington, DC); Marchionini, Brian (Energetics, Inc., Washington, DC); Fall, Ndeye K. (Energetics, Inc., Washington, DC)

    2007-07-01

    In 1997, an international team interested in the development of Remote Area Power Supply (RAPS) systems for rural electrification projects around the world was organized by the International Lead Zinc Research Organization (ILZRO) with the support of Sandia National Laboratories (SNL). The team focused on defining load and resource profiles for RAPS systems. They identified single family homes, small communities, and villages as candidates for RAPS applications, and defined several different size/power requirements for each. Based on renewable energy and resource data, the team devised a ''strawman'' series of load profiles. A RAPS system typically consists of a renewable and/or conventional generator, power conversion equipment, and a battery. The purpose of this report is to present data and information on insolation levels and load requirements for ''typical'' homes, small communities, and larger villages around the world in order to facilitate the development of robust design practices for RAPS systems, and especially for the storage battery component. These systems could have significant impact on areas of the world that would otherwise not be served by conventional electrical grids.

  14. LHC rap: a global phenomenon

    CERN Multimedia

    2008-01-01

    Do you think the LHC is super duper fly? Does it make you want to compose some slick rhymes and bust out some killer beats? It did for one CERN rapper, and the results have become a YouTube smash hit! Katie McAlpine will sing for the CMS party on 24 September, and for the ATLAS Fest on 4 October.The Large Hadron Rap, to give it its full name, is the brainchild of AlpineKat, AKA Katie McAlpine, who is currently working for ATLAS e-News and outreach. To date, the YouTube video rap has been viewed more than 2.5 million times, to say nothing of the media coverage. Featured in newspapers around the world, including the New York Times in the US, The Telegraph in the UK and Geneva’s very own Matin Bleu, the rap is officially a sensation! Katie wrote the inspired (and pretty accurate) physics lyrics during her commute on the number 56 bus between Geneva and CERN. After obtaining permission to film in the experiment caverns and tunnel,...

  15. Cobalt production in RAPS-1

    International Nuclear Information System (INIS)

    Krishnan, P.D.; Purandare, H.D.

    1978-01-01

    At present in RAPS-1 radioisotope Co 60 is produced by irradiating Co 59 in the adjusters which perform the function of regulation of reactivity, power and xenon override. But the manrem expenditure of the crew handling the charge and discharge of the adjusters is going to be prohibitively high. It is therefore proposed to irradiate Co 59 in the fuel channel positions. The physics optimisation study for such irradiation is presented. The burnup penalty and loss of power are estimated to produce the required quantity of Co 60 after optimising the number of cobalt pencils in a bundle and the positions of the cobalt producing channels in the reactor core. (author)

  16. Translating Chicana Rap: Snow Tha Product

    Directory of Open Access Journals (Sweden)

    Adriana Onita

    2017-06-01

    Full Text Available This project examines rap lyrics, interviews, and music videos by Chicana artist Snow Tha Product to show how rap has been culturally translated, performed, and appropriated by females in order to “flip the script,” or subvert the dichotomous model of female sexuality that has been imposed upon them. Weaving insights from three academic fields (cultural translation, Chican@ studies, and hip-hop feminism, this paper also aims to creatively expand the definition of translation by positioning rap music as a performative language in its own right, capable of encoding and translating complex cultural issues related to race, gender, and sexuality.

  17. Joint Advisory Appeals Board report

    CERN Document Server

    Lalande, Amanda

    2018-01-01

    With regard to the internal appeal procedure, Article R VI 1.18 of the Staff Rules and Regulations states that unless the member of the personnel objects, (the) decision and report of the JAAB (Joint Advisory Appeals Board) shall be brought to the attention of the members of the personnel.

  18. Molecular characterization of the Babesia caballi rap-1 gene and epidemiological survey in horses in Israel.

    Science.gov (United States)

    Rapoport, Adi; Aharonson-Raz, Karin; Berlin, Dalia; Tal, Saar; Gottlieb, Yuval; Klement, Eyal; Steinman, Amir

    2014-04-01

    Equine piroplasmosis imposes great concerns for the equine industry regarding international horse movement, and therefore requires reliable diagnostic tools. Recent studies from South Africa and Jordan, including a preliminary study in Israel, reported extremely low seroprevalence to Babesia caballi (B. caballi) (0-1%) using the acceptable rhoptry-associated protein-1 (RAP-1) cELISA. In accordance with the study from South Africa demonstrating a significant heterogeneity in the rap-1 gene sequence of South African B. caballi isolates, the objectives of this study were to phylogenetically characterize the rap-1 gene of the Israeli isolates and determine the prevalence of B. caballi in horses in Israel. Out of 273 horses tested using the RAP-1 cELISA, only one was sero-positive, while 9.3% were positive on PCR performed on the rap-1 gene. Phylogenetic analysis of the rap-1 gene grouped the Israeli isolates in a cluster together with the South African strains (99% nt identity), but in a separate cluster from the American/Caribbean strains (81-82% nt identity). These findings support the existence of heterogeneity in the RAP-1 amino-acid sequences of the Israeli and South African isolates as compared to that used in the cELISA commercial kit and raise doubts as to the ability of this assay to serve as a sole regulatory test for international horse movement. Risk factor analysis found management and age to significantly associate with prevalence of B. caballi, as higher prevalence was noted in horses held out on pasture and a negative association was recorded with age. In addition, B. caballi was not detected in horses in the steppe-arid and extreme-arid climatic regions as compared to the wetter regions. Findings of this study emphasize the need to combine several detection methods to ameliorate the control and spread of the disease. Copyright © 2014 Elsevier B.V. All rights reserved.

  19. Joint Advisory Appeals Board

    CERN Multimedia

    2013-01-01

    The Joint Advisory Appeals Board has examined the internal appeal lodged by a former member of the personnel, a beneficiary of the CERN Pension Fund, against the calculation of his pension in the framework of the Progressive Retirement Programme.   The person concerned has not objected to the report of the Board and the final decision of the Director-General being brought to the attention of the members of the personnel. In application of Article R VI 1.18 of the Staff Regulations, these documents will therefore be available from 26 July to 11 August 2013 at the following link. HR Department Head Office

  20. Joint Advisory Appeals Board

    CERN Multimedia

    HR Department

    2008-01-01

    The Joint Advisory Appeals Board has examined the internal appeal lodged by a member of the personnel against the decision to grant him only a periodic one-step advancement for the 2006 reference year. The person concerned has not objected to the report of the Board and the final decision of the Director-General being brought to the attention of the members of the personnel. In application of Article R VI 1.18 of the Staff Regulations, these documents will therefore be posted on the notice board of the Main building (bldg. 500) from 1 September to 14 September 2008. Human Resources Department (73911)

  1. Joint Advisory Appeals Board

    CERN Multimedia

    HR Department

    2007-01-01

    The Joint Advisory Appeals Board was convened to examine an internal appeal lodged by a member of the personnel with regard to the decision not to grant him an indefinite contract. The person concerned has requested that the report of the Board and the final decision of the Director-General be brought to the notice of the members of the personnel, in accordance with Article R VI 1.18 of the Staff Regulations. The relevant documents will therefore be posted on the notice board of the Main building (Bldg. 60) from 24 September to 7 October 2007. Human Resources Department

  2. Joint Advisory Appeals Board

    CERN Multimedia

    HR Department

    2008-01-01

    The Joint Advisory Appeals Board has examined the internal appeal lodged by a member of the personnel with regard to the decision not to award him a periodic one-step advancement for the 2006 reference year. The person concerned has not objected to the report of the Board and the final decision of the Director-General being brought to the notice of the members of the personnel. In application of Article R VI 1.18 of the Staff Regulations, these documents will therefore be posted on the notice board of the Main building (Bldg. 500) from 17 March to 30 March 2008. Human Resources Department Tel. 73911

  3. Joint Advisory Appeals Board

    CERN Multimedia

    HR Department

    2008-01-01

    The Joint Advisory Appeals Board has examined the internal appeal lodged by a member of the personnel against the decision to grant him only a periodic one-step advancement for the 2006 reference year. The person concerned has not objected to the report of the Board and the final decision of the Director-General being brought to the attention of the members of the personnel. In application of Article R VI 1.18 of the Staff Regulations, these documents will therefore be posted on the notice board of the Main Building (Bldg. 500) from 1 September to 14 September 2008. Human Resources Department (73911)

  4. Joint Advisory Appeals Board

    CERN Multimedia

    HR Department

    2008-01-01

    The Joint Advisory Appeals Board has examined the internal appeal lodged by a member of the personnel with regard to the decision not to grant him an indefinite contract. The person concerned has not objected to the report of the Board and the final decision of the Director-General being brought to the notice of the members of the personnel. In application of Article R VI 1.18 of the Staff Regulations, these documents will therefore be posted on the notice board of the Main Building (Bldg. 500) from 26 May to 6 June 2008. Human Resources Department (73911)

  5. Joint Advisory Appeals Board

    CERN Multimedia

    HR Department

    2008-01-01

    The Joint Advisory Appeals Board was convened to examine an internal appeal lodged by a member of the personnel with regard to the decision not to grant him an indefinite contract. The person concerned has not objected to the report of the Board and the final decision of the Director-General being brought to the notice of the members of the personnel, in accordance with Article R VI 1.18 of the Staff Regulations. These documents will therefore be posted on the notice board of the Main Building (Bldg. 60) from 21 January to 3 February 2008. Human Resources Department (73911)

  6. Rapping dyslexia : learning rhythm, rhyme and flow in dyslectic children

    NARCIS (Netherlands)

    Tittarelli, M.; Marti, P.; Peppoloni, D.

    2014-01-01

    The paper presents a design case that draws inspiration from rap music as a way to tell stories rhythmically, with simple instruments for accompaniment. Rhythm, rhymes and flow are key features of rap music. In this study, we attempted to apply rap principles and dynamics to a very specific field of

  7. Use of technology in implementing radiation protection good practices at RAPS-5 and 6

    International Nuclear Information System (INIS)

    Nawal, S.R.; Kakkar, Amandeep; Yadav, Umed; Venkataramana, K.; Ramasomayajulu, M.; Khot, Pankaj

    2014-01-01

    Nuclear Power Corporation of India Ltd (NPCIL), is committed to perform all its activities while providing high level of radiological protection and continue to meet international standards on radiological safety. In continuation to reducing in expenditure of station collective dose/individual dose both in terms of external and internal dose is attained by adopting many new and innovative good radiological practices as per ALARA principle. Some of these improved radiological practices of RAPS-5 and 6 are discussed in this paper

  8. Structural Basis of Rap Phosphatase Inhibition by Phr Peptides

    Science.gov (United States)

    Gallego del Sol, Francisca; Marina, Alberto

    2013-01-01

    Two-component systems, composed of a sensor histidine kinase and an effector response regulator (RR), are the main signal transduction devices in bacteria. In Bacillus, the Rap protein family modulates complex signaling processes mediated by two-component systems, such as competence, sporulation, or biofilm formation, by inhibiting the RR components involved in these pathways. Despite the high degree of sequence homology, Rap proteins exert their activity by two completely different mechanisms of action: inducing RR dephosphorylation or blocking RR binding to its target promoter. However the regulatory mechanism involving Rap proteins is even more complex since Rap activity is antagonized by specific signaling peptides (Phr) through a mechanism that remains unknown at the molecular level. Using X-ray analyses, we determined the structure of RapF, the anti-activator of competence RR ComA, alone and in complex with its regulatory peptide PhrF. The structural and functional data presented herein reveal that peptide PhrF blocks the RapF-ComA interaction through an allosteric mechanism. PhrF accommodates in the C-terminal tetratricopeptide repeat domain of RapF by inducing its constriction, a conformational change propagated by a pronounced rotation to the N-terminal ComA-binding domain. This movement partially disrupts the ComA binding site by triggering the ComA disassociation, whose interaction with RapF is also sterically impaired in the PhrF-induced conformation of RapF. Sequence analyses of the Rap proteins, guided by the RapF-PhrF structure, unveil the molecular basis of Phr recognition and discrimination, allowing us to relax the Phr specificity of RapF by a single residue change. PMID:23526880

  9. Rap G protein signal in normal and disordered lymphohematopoiesis.

    Science.gov (United States)

    Minato, Nagahiro

    2013-09-10

    Rap proteins (Rap1, Rap2a, b, c) are small molecular weight GTPases of the Ras family. Rap G proteins mediate diverse cellular events such as cell adhesion, proliferation, and gene activation through various signaling pathways. Activation of Rap signal is regulated tightly by several specific regulatory proteins including guanine nucleotide exchange factors and GTPase-activating proteins. Beyond cell biological studies, increasing attempts have been made in the past decade to define the roles of Rap signal in specific functions of normal tissue systems as well as in cancer. In the immune and hematopoietic systems, Rap signal plays crucial roles in the development and function of essentially all lineages of lymphocytes and hematopoietic cells, and importantly, deregulated Rap signal may lead to unique pathological conditions depending on the affected cell types, including various types of leukemia and autoimmunity. The phenotypical studies have unveiled novel, even unexpected functional aspects of Rap signal in cells from a variety of tissues, providing potentially important clues for controlling human diseases, including malignancy. © 2013 Elsevier Inc. All rights reserved.

  10. Consideration on application of RAP to G-II NPP

    International Nuclear Information System (INIS)

    Shen Shen

    2010-01-01

    The design (D-RAP) for nuclear power plant has been adopted internationally in new-build advanced nuclear power plant design, which increases the ability of the risk-significant SSCs to carry out its functions during the accident circumstances especially in the severe accident situation, and reduces the risk of a nuclear power plant. The concept of reliability assurance program for advanced nuclear power plant can also be applied to nuclear power plants which second-generation NPP technology is used. Through analysis and research, the risk-significant SSCs in actual NPP can also be screened, and these SSCs can be managed appropriately, so that can improve the overall plant ability to against the severe accident, reduce the risk, and improve their safety and economy. Also such technology used does not exist any insurmountable technical difficulties and a lot of money input. (authors)

  11. 19 CFR 210.24 - Interlocutory appeals.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Interlocutory appeals. 210.24 Section 210.24 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT Motions § 210.24 Interlocutory appeals. Rulings by the administrative...

  12. 19 CFR 210.64 - Interlocutory appeals.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Interlocutory appeals. 210.64 Section 210.64 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT Temporary Relief § 210.64 Interlocutory appeals. There will be no...

  13. 7 CFR 1580.505 - Appeals

    Science.gov (United States)

    2010-01-01

    ... AGRICULTURE TRADE ADJUSTMENT ASSISTANCE FOR FARMERS § 1580.505 Appeals Any person aggrieved by a final determination made with respect to an application for program benefits under this part may appeal to the United States Court of International Trade for a review of such determination, in accordance with its rules and...

  14. Rap Music Literacy: A Case Study of Millennial Audience Reception to Rap Lyrics Depicting Independent Women

    Science.gov (United States)

    Moody-Ramirez, Mia; Scott, Lakia M.

    2015-01-01

    Using a feminist lens and a constructivist approach as the theoretical framework, we used rap lyrics and videos to help college students explore mass media's representation of the "independent" Black woman and the concept of "independence" in general. Students must be able to formulate their own concept of independence to…

  15. Requirement of the Caenorhabditis elegans RapGEF pxf-1 and rap-1 for epithelial integrity

    Czech Academy of Sciences Publication Activity Database

    Pellis-van Berkel, W.; Verheijen, M. H. G.; Cuppen, E.; Asahina, Masako; de Rooij, J.; Jansen, G.; Plasterk, R. H. A.; Bos, J. L.; Zwartkruis, F. J. T.

    2005-01-01

    Roč. 16, č. 1 (2005), s. 106-116 ISSN 1059-1524 R&D Projects: GA AV ČR KJB5022303 Institutional research plan: CEZ:AV0Z60220518 Keywords : Rap signaling pathway * epidermis * Caenorhabditis elegans Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 6.520, year: 2005

  16. Ageing management studies of RAPS-1

    International Nuclear Information System (INIS)

    Bohra, A.K.; Jain, L.K.; Joshi, K.M.

    2006-01-01

    Unit-l of Rajasthan Atomic Power Station (RAPS-1) is the first nuclear power plant of India with pressurized heavy water reactor. The construction of Unit-l of Rajasthan Atomic Power Station (RAPS-1) was started in the year 1966 in collaboration with Canada. The Unit-1 achieved first criticality on August 1972 and was first synchronized to Grid on November 1972. During initial operation of the Unit, several problems were faced in its various systems and these were addressed by incorporating various engineering changes and procedures. In this unit various major innovative repairs were done like end shield leak repair, OPRD leak repair. Considering the operation of various systems of Unit-1, since year 1971 it was imperative to study ageing degradation mechanisms and mitigating measures were to be taken. Although the ageing management is a continuous process the opportunity of Unit-1 shutdown for upgradations from 30-04-2002 to 08-02-2004 was utilized for inspection and assessment of health of various SSC, which otherwise could not have been done with unit in operational state. This paper contains the following in detail. (1) Ageing management programme, its objectives and scope (2) Methodology of ageing management studies - Replacement and upgradation -Additional inspection programme based on ageing management review - Statistical analysis of ageing degradation occurrence - Estimation of residual life span of cables and relays (3) Criteria for selection of components for ageing management programme (4) Findings of ageing management studies-case studies. The ageing study done for RAPS-1 indicated that appropriate ageing monitoring methods and procedures exist in the station for taking timely mitigating measures. The technological obsoleteness has been overcome by installing new components of latest technology. On overall assessment, the Unit-1 was considered fit for further service. (author)

  17. Apical accumulation of the Sevenless receptor tyrosine kinase during Drosophila eye development is promoted by the small GTPase Rap1.

    Science.gov (United States)

    Baril, Caroline; Lefrançois, Martin; Sahmi, Malha; Knævelsrud, Helene; Therrien, Marc

    2014-08-01

    The Ras/MAPK-signaling pathway plays pivotal roles during development of metazoans by controlling cell proliferation and cell differentiation elicited, in several instances, by receptor tyrosine kinases (RTKs). While the internal mechanism of RTK-driven Ras/MAPK signaling is well understood, far less is known regarding its interplay with other co-required signaling events involved in developmental decisions. In a genetic screen designed to identify new regulators of RTK/Ras/MAPK signaling during Drosophila eye development, we identified the small GTPase Rap1, PDZ-GEF, and Canoe as components contributing to Ras/MAPK-mediated R7 cell differentiation. Rap1 signaling has recently been found to participate in assembling cadherin-based adherens junctions in various fly epithelial tissues. Here, we show that Rap1 activity is required for the integrity of the apical domains of developing photoreceptor cells and that reduced Rap1 signaling hampers the apical accumulation of the Sevenless RTK in presumptive R7 cells. It thus appears that, in addition to its role in cell-cell adhesion, Rap1 signaling controls the partitioning of the epithelial cell membrane, which in turn influences signaling events that rely on apico-basal cell polarity. Copyright © 2014 by the Genetics Society of America.

  18. Medicare Appeals Council Decisions

    Data.gov (United States)

    U.S. Department of Health & Human Services — Decisions of the Departmental Appeals Board's Medicare Appeals Council involving claims for entitlement to Medicare and individual claims for Medicare coverage and...

  19. Nucleotide sequence of a human cDNA encoding a ras-related protein (rap1B)

    Energy Technology Data Exchange (ETDEWEB)

    Pizon, V; Lerosey, I; Chardin, P; Tavitian, A [INSERM, Paris (France)

    1988-08-11

    The authors have previously characterized two human ras-related genes rap1 and rap2. Using the rap1 clone as probe they isolated and sequenced a new rap cDNA encoding the 184aa rap1B protein. The rap1B protein is 95% identical to rap1 and shares several properties with the ras protein suggesting that it could bind GTP/GDP and have a membrane location. As for rap1, the structural characteristics of rap1B suggest that the rap and ras proteins might interact on the same effector.

  20. Is Pluto a planet? Student powered video rap ';battle' over tiny Pluto's embattled planetary standing

    Science.gov (United States)

    Beisser, K.; Cruikshank, D. P.; McFadden, T.

    2013-12-01

    Is Pluto a planet? Some creative low income Bay-area middle-schoolers put a musical spin on this hot science debate with a video rap ';battle' over tiny Pluto's embattled planetary standing. The students' timing was perfect, with NASA's New Horizons mission set to conduct the first reconnaissance of Pluto and its moons in July 2015. Pluto - the last of the nine original planets to be explored by spacecraft - has been the subject of scientific study and speculation since Clyde Tombaugh discovered it in 1930, orbiting the Sun far beyond Neptune. Produced by the students and a very creative educator, the video features students 'battling' back and forth over the idea of Pluto being a planet. The group collaborated with actual space scientists to gather information and shot their video before a 'green screen' that was eventually filled with animations and visuals supplied by the New Horizons mission team. The video debuted at the Pluto Science Conference in Maryland in July 2013 - to a rousing response from researchers in attendance. The video marks a nontraditional approach to the ongoing 'great planet debate' while educating viewers on a recently discovered region of the solar system. By the 1990s, researchers had learned that Pluto possessed multiple exotic ices on its surface, a complex atmosphere and seasonal cycles, and a large moon (Charon) that likely resulted from a giant impact on Pluto itself. It also became clear that Pluto was no misfit among the planets - as had long been thought - but the largest and brightest body in a newly discovered 'third zone' of our planetary system called the Kuiper Belt. More recent observations have revealed that Pluto has a rich system of satellites - five known moons - and a surface that changes over time. Scientists even speculate that Pluto may possess an internal ocean. For these and other reasons, the 2003 Planetary Decadal Survey ranked a Pluto/Kuiper Belt mission as the highest priority mission for NASA's newly created

  1. Rap Music Genres and Deviant Behaviors in French-Canadian Adolescents

    Science.gov (United States)

    Miranda, Dave; Claes, Michel

    2004-01-01

    This study investigated the links between the preference for 4 rap music genres (American rap, French rap, hip hop/soul, and gangsta/hardcore rap) and 5 types of deviant behaviors in adolescence (violence, theft, street gangs, mild drug use, and hard drug use). The effects of peers' deviancy, violent media, and importance given to lyrics were…

  2. Molas Baju Wara: Hybridity in Manggarai Rap Music

    Directory of Open Access Journals (Sweden)

    Ans. Prawati Yuliantari

    2017-06-01

    Full Text Available Rap music which has been popular since 2007 in Manggarai region, East Nusa Tenggara, Indonesia, gave rise to rap hybrid phenomenon. The mixture between American rap music formats and local elements of Manggarai attracted the attention of young people in the region. One of the local songs that feature hybridity in rap Manggarai is "Molas Baju Wara" created by Lipooz, one of the pioneers of rap in Ruteng, the capital city of Manggarai district. To discuss this phenomenon, the concept of hybridity in cultural territory proposed by James Lull is adopted. This concept is used particularly to analyze the forms of hybridity reflected in " Molas Baju Wara" and the ways they are used in showing the social and cultural conditions of Manggarai. "Molas Baju Wara" was selected as the object of study because the song is clearly showing the characteristics of hybridity in music. The study shows that hybridity could be perceived in Manggarai rap music specifically in the use of local musical instruments like drums, cajon, and tambourine as a substitute for percussive sounds of drums, boombox, or turn-table which are commonly used by rap musicians in their home country, the U.S.A. In addition, there are elements of local sound such as the sound of rain that represents Ruteng as the rain city. Hybridity characteristics can also be found in the use of Manggarai vernacular in the whole lyrics as well as the narration of local themes and certain sites that represent Ruteng.

  3. "Everybody Gotta Have a Dream": Rap-centered Aspirations among Young Black Males Involved in Rap Music Production - A Qualitative Study.

    Science.gov (United States)

    Foster, B Brian

    Youth express diverse desires for their educational and occupational futures. Sometimes these aspirations are directed towards somewhat unconventional careers such as rapping and other types of involvement in rap music production. Although many studies have examined traditional educational and occupational aspirations, less is known about the factors that give rise to rap-centered aspirations and how individuals pursue them, particularly as they transition to early adulthood. Drawing on 54 semi- and unstructured interviews with 29 black young men involved in rap music production, I find that rap-centered aspirations are shaped by a range of factors, most notably feedback regarding one's rap skills, access to recording and production equipment, and the financial means to maintain involvement in rap music production while also ensuring personal and family economic stability. The young men in the study attached different meanings to their aspirations and sometimes recast their motivations for participating in rap music production in response to various social and economic factors.

  4. Determination of usable residual asphalt binder in RAP.

    Science.gov (United States)

    2009-01-01

    For current recycled mix designs, the Illinois Department of Transportation (IDOT) assumes 100% contribution of : working binder from Recycled Asphalt Pavement (RAP) materials when added to Hot Mix Asphalt (HMA). However, it is : unclear if this assu...

  5. Overview of the remedial action priority system (RAPS)

    International Nuclear Information System (INIS)

    Whelan, G.; Steelman, B.L.; Strenge, D.L.; Droppo, J.G.

    1986-01-01

    To provide DOE with a better management tool for prioritizing funding allocations for further site investigations and possible remediations, Pacific Northwest Laboratory developed a more objective, physics-based risk assessment methodology called the Remedial Action Priority System (RAPS). This methodology uses empirically, analytically, and semianalytically based mathematical algorithms and a pathways analysis to predict the potential for contaminant transport from a hazardous waste disposal site to local populations. Four major pathways for contaminant migration are considered in the RAPS methodology: groundwater, overland, surface water, and atmospheric. Using the predications of contaminant transport, simplified exposure assessments are performed for important receptors. The risks associated with the sites can then be calculated relative to other sites for each pathway and for all pathways together. The RAPS methodology addresses many of the typical limitations associated with other ranking systems; it considers: (1) more site information and constituent characteristics associated with the transport pathways; (2) chemical and radioactive wastes; (3) the potential direction of contaminant movement; (4) contaminant retention (e.g., dispersion and decay/degradation), where applicable; (5) population distributions; (6) various routes of exposure (e.g., inhalations, ingestion, and external exposure); (7) contaminant toxicities; (8) duration of exposure of the surrounding population; and (9) contaminant arrival time to sensitive receptors. Because RAPS is based on more site information and constituent characteristics, the scoring system of the RAPS methodology also reduces the subjectivity associated with prioritizing hazardous waste sites. The RAPS methodology requires minimum user knowledge of risk assessment and a minimum amount of input data

  6. Mutations in CDK5RAP2 cause Seckel syndrome.

    Science.gov (United States)

    Yigit, Gökhan; Brown, Karen E; Kayserili, Hülya; Pohl, Esther; Caliebe, Almuth; Zahnleiter, Diana; Rosser, Elisabeth; Bögershausen, Nina; Uyguner, Zehra Oya; Altunoglu, Umut; Nürnberg, Gudrun; Nürnberg, Peter; Rauch, Anita; Li, Yun; Thiel, Christian Thomas; Wollnik, Bernd

    2015-09-01

    Seckel syndrome is a heterogeneous, autosomal recessive disorder marked by prenatal proportionate short stature, severe microcephaly, intellectual disability, and characteristic facial features. Here, we describe the novel homozygous splice-site mutations c.383+1G>C and c.4005-9A>G in CDK5RAP2 in two consanguineous families with Seckel syndrome. CDK5RAP2 (CEP215) encodes a centrosomal protein which is known to be essential for centrosomal cohesion and proper spindle formation and has been shown to be causally involved in autosomal recessive primary microcephaly. We establish CDK5RAP2 as a disease-causing gene for Seckel syndrome and show that loss of functional CDK5RAP2 leads to severe defects in mitosis and spindle organization, resulting in cells with abnormal nuclei and centrosomal pattern, which underlines the important role of centrosomal and mitotic proteins in the pathogenesis of the disease. Additionally, we present an intriguing case of possible digenic inheritance in Seckel syndrome: A severely affected child of nonconsanguineous German parents was found to carry heterozygous mutations in CDK5RAP2 and CEP152. This finding points toward a potential additive genetic effect of mutations in CDK5RAP2 and CEP152.

  7. Mutations in CDK5RAP2 cause Seckel syndrome

    Science.gov (United States)

    Yigit, Gökhan; Brown, Karen E; Kayserili, Hülya; Pohl, Esther; Caliebe, Almuth; Zahnleiter, Diana; Rosser, Elisabeth; Bögershausen, Nina; Uyguner, Zehra Oya; Altunoglu, Umut; Nürnberg, Gudrun; Nürnberg, Peter; Rauch, Anita; Li, Yun; Thiel, Christian Thomas; Wollnik, Bernd

    2015-01-01

    Seckel syndrome is a heterogeneous, autosomal recessive disorder marked by prenatal proportionate short stature, severe microcephaly, intellectual disability, and characteristic facial features. Here, we describe the novel homozygous splice-site mutations c.383+1G>C and c.4005-9A>G in CDK5RAP2 in two consanguineous families with Seckel syndrome. CDK5RAP2 (CEP215) encodes a centrosomal protein which is known to be essential for centrosomal cohesion and proper spindle formation and has been shown to be causally involved in autosomal recessive primary microcephaly. We establish CDK5RAP2 as a disease-causing gene for Seckel syndrome and show that loss of functional CDK5RAP2 leads to severe defects in mitosis and spindle organization, resulting in cells with abnormal nuclei and centrosomal pattern, which underlines the important role of centrosomal and mitotic proteins in the pathogenesis of the disease. Additionally, we present an intriguing case of possible digenic inheritance in Seckel syndrome: A severely affected child of nonconsanguineous German parents was found to carry heterozygous mutations in CDK5RAP2 and CEP152. This finding points toward a potential additive genetic effect of mutations in CDK5RAP2 and CEP152. PMID:26436113

  8. 15 CFR 303.13 - Appeals.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Appeals. 303.13 Section 303.13 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) INTERNATIONAL... and two copies with the U.S. Department of Commerce, Import Administration, International Trade...

  9. Source localization using recursively applied and projected (RAP) MUSIC

    Energy Technology Data Exchange (ETDEWEB)

    Mosher, J.C. [Los Alamos National Lab., NM (United States); Leahy, R.M. [Univ. of Southern California, Los Angeles, CA (United States). Signal and Image Processing Inst.

    1998-03-01

    A new method for source localization is described that is based on a modification of the well known multiple signal classification (MUSIC) algorithm. In classical MUSIC, the array manifold vector is projected onto an estimate of the signal subspace, but errors in the estimate can make location of multiple sources difficult. Recursively applied and projected (RAP) MUSIC uses each successively located source to form an intermediate array gain matrix, and projects both the array manifold and the signal subspace estimate into its orthogonal complement. The MUSIC projection is then performed in this reduced subspace. Using the metric of principal angles, the authors describe a general form of the RAP-MUSIC algorithm for the case of diversely polarized sources. Through a uniform linear array simulation, the authors demonstrate the improved Monte Carlo performance of RAP-MUSIC relative to MUSIC and two other sequential subspace methods, S and IES-MUSIC.

  10. Life extension and replacement management for RAPS type steam generators

    International Nuclear Information System (INIS)

    Arya, R.C.; Rastogi, A.K.

    1996-01-01

    The steam generating equipment in first four units of Indian PHWRs Rajasthan Atomic Power Station (RAPS) 1-2 and Madras Atomic Power Station (MAPS) 1-2 are hairpin type and comprise of eight boiler assemblies. Each assembly consists of identical, single pass, inverted and vertical hairpin heat exchangers (10 for RAPS and 11 for MAPS) containing 195 monel-400 U tubes of 12.7 mm dia x 1.242 mm thick. The hot heavy water flows through these tubes and imparts heat to feed, light demineralized water entering the shell at the bottom of preheat leg. The heat is generated on the outer surface of the tubes. Details of studies carried out for life extension and replacement management for RAPS type steam generators are given. 1 fig., 5 tabs

  11. The Remedial Action Priority System (RAPS): Mathematical formulations

    International Nuclear Information System (INIS)

    Whelan, G.; Strenge, D.L.; Droppo, J.G. Jr.; Steelman, B.L.; Buck, J.W.

    1987-08-01

    The Remedial Action Priority System (RAPS) represents a methodology that prioritizes inactive hazardous and radioactive mixed-waste disposal sites in a scientific and objective manner based on limited site information. This methodology is intended to bridge the technology gap between the initial site evaluation using the Hazard Ranking System (HRS) and the time-consuming process of actual field site characterization, assessment, and remediation efforts. The RAPS methodology provides the US Department of Energy with a management tool for assistance in prioritizing funding and human resource allocations for further investigations and possible remediations at its inactive waste sites. Use of RAPS will help DOE ensure that those sites posing the highest potential risk are addressed first. Chapters 1 through 10 were processed separately for the Energy Data Base

  12. Novel Alternative Splice Variants of Mouse Cdk5rap2.

    Directory of Open Access Journals (Sweden)

    Nadine Kraemer

    Full Text Available Autosomal recessive primary microcephaly (MCPH is a rare neurodevelopmental disorder characterized by a pronounced reduction of brain volume and intellectual disability. A current model for the microcephaly phenotype invokes a stem cell proliferation and differentiation defect, which has moved the disease into the spotlight of stem cell biology and neurodevelopmental science. Homozygous mutations of the Cyclin-dependent kinase-5 regulatory subunit-associated protein 2 gene CDK5RAP2 are one genetic cause of MCPH. To further characterize the pathomechanism underlying MCPH, we generated a conditional Cdk5rap2 LoxP/hCMV Cre mutant mouse. Further analysis, initiated on account of a lack of a microcephaly phenotype in these mutant mice, revealed the presence of previously unknown splice variants of the Cdk5rap2 gene that are at least in part accountable for the lack of microcephaly in the mice.

  13. Departmental Appeals Board Decisions

    Data.gov (United States)

    U.S. Department of Health & Human Services — Decisions issued by the Chair and Board Members of the Departmental Appeals Board concerning determinations in discretionary, project grant programs, including...

  14. Entre ritmo e poesia: rap e literatura oral urbana

    Directory of Open Access Journals (Sweden)

    Marcus Rogerio Salgado

    2015-11-01

    Full Text Available O objetivo do presente artigo é um estudo do rap enquanto manifestação de literatura oral urbana e forma de oralidade tecnológica. Para tanto, o artigo passará em revista as relações entre literatura e palavra falada/cantada, assim como as possibilidades de interface estética entre a literatura e a música que estão em questão quando tratamos do rap.

  15. 3D printing with RepRap cookbook

    CERN Document Server

    Salinas, Richard

    2014-01-01

    A systematic guide consisting of over 100 recipes which focus on helping you understand the process of 3D printing using RepRap machines. The book aims at providing professionals with a series of working recipes to help make their fuzzy notions into real, saleable projects/objects using 3D printing technology. This book is for novice designers and artists who own a RepRap-based 3D printer, have fundamental knowledge of its working, and who desire to gain better mastery of the printing process. For the more experienced user, it will provide a handy visual resource, with side-by-side comparisons

  16. RAP-1a is the main rhoptry-associated-protein-1 (RAP-1) recognized during infection with Babesia sp. BQ1 (Lintan) (B. motasi-like phylogenetic group), a pathogen of sheep in China.

    Science.gov (United States)

    Niu, Qingli; Bonsergent, Claire; Rogniaux, Hélène; Guan, Guiquan; Malandrin, Laurence; Moreau, Emmanuelle

    2016-12-15

    Babesia sp. BQ1 (Lintan) is one of the parasites isolated from infected sheep in China that belongs to the B. motasi-like phylogenetic group. The rhoptry-associated-protein 1 (rap-1) locus in this group consists of a complex organization of 12 genes of three main types: 6 rap-1a variants intercalated with 5 identical copies of rap-1b and a single 3' ending rap-1c gene. In the present study, transcription analysis performed by standard RT-PCR demonstrated that the three different rap-1 gene types and the four rap-1a variants were transcribed by the parasite cultivated in vitro. Peptides, specific for each rap-1 type gene, were selected in putative linear B-epitopes and used to raise polyclonal rabbit antisera. Using these sera, the same expression pattern of RAP-1 proteins was found in parasites cultivated in vitro or collected from acute infection whereas only RAP-1a67 was detectable in merozoite extracts. However, ELISA performed with recombinant RAP-1a67, RAP-1b or RAP-1c and sera from infected sheep demonstrated that RAP-1a67 is the main RAP-1 recognized during infection, even if some infected sheep also recognized RAP-1b and/or RAP-1c. Copyright © 2016 Elsevier B.V. All rights reserved.

  17. Chance Encounters: Rap Music as a Relational and Pedagogical Resource in Clinical Pastoral Education.

    Science.gov (United States)

    Gilmore, Jeremy

    2018-03-01

    Music has long been regarded as a valuable tool for educators. Over the last three decades, rap music has grown to become a global phenomenon. However, due to historical and cultural factors, rap music is often underutilized in Clinical Pastoral Education. This article discusses the social significance of rap music, highlights how rap music informed my supervision of a clinical pastoral education student, and examines Chance the Rapper's mixtape Coloring Book as a case study on the utilization of rap music as a relational and pedagogical resource in spiritual education.

  18. 22 CFR 224.41 - Stay pending appeal.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Stay pending appeal. 224.41 Section 224.41 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL REMEDIES ACT § 224.41 Stay pending appeal. (a) An initial decision is stayed automatically pending disposition...

  19. Rap Therapy? An Innovative Approach to Groupwork with Urban Adolescents.

    Science.gov (United States)

    DeCarlo, Alonzo

    2001-01-01

    Describes a study in which young, urban African American adolescents with behavior problems participated in weekly group sessions that used rap music to promote the development of appropriate social skills related to morality, identity, judgement, decision making, anger management, impulse control, and crime and punishment. Overall, student…

  20. Migrant Rap in the Periphery: Performing Politics of Belonging

    Science.gov (United States)

    Leppänen, Sirpa; Westinen, Elina

    2017-01-01

    Focusing on a YouTube performance by an emergent Finnish Somali rapper and the audience responses it has generated, this paper looks at ways in which rap music engages with the issue of belonging. Drawing on recent theorizations of belonging as a multi-dimensional, contingent and fluid process, along with sociolinguistic work on globalization and…

  1. Hybrid Texts: Fifth Graders, Rap Music, and Writing

    Science.gov (United States)

    Christianakis, Mary

    2011-01-01

    Consistent with a sociocritical frame and the analytic tools of hybridity theory, this article explicates how urban fifth-grade children made language hybrids using rap and poetry to participate in classroom literacy. Ethnographic data from a yearlong study illustrate two key findings. First, standards-based and canon-driven writing models…

  2. ‘When i rap, i feel more like myself’

    DEFF Research Database (Denmark)

    Vitus, Kathrine

    2016-01-01

    This article analyzes the relationship between subjectivity and ideology in a short film, Rapper Girl, produced by young women living in multiethnic Copenhagen, and develops the concept of the ‘RapX fantasy’. Through Jacques Rancière’s and Slavoj Žižek’s theoretical lenses, the article explores how...

  3. Synergistic Regulation of Competence Development in Bacillus subtilis by Two Rap-Phr Systems† ‡

    Science.gov (United States)

    Bongiorni, Cristina; Ishikawa, Shu; Stephenson, Sophie; Ogasawara, Naotake; Perego, Marta

    2005-01-01

    The 11 Rap proteins of Bacillus subtilis comprise a conserved family of tetratricopeptide (TPR)-containing regulatory proteins. Their activity is inhibited by specific Phr pentapeptides produced from the product of phr genes through an export-import maturation process. We found that one of the proteins, namely RapF, is involved in the regulation of competence to DNA transformation. The ComA response regulator and transcription factor for initiation of competence development is the target of RapF. Specific binding of RapF to the carboxy-terminal DNA-binding domain of ComA inhibits the response regulator's ability to bind its target DNA promoters. The PhrF C-terminal pentapeptide, QRGMI, inhibits RapF activity. The activity of RapF and PhrF in regulating competence development is analogous to the previously described activity of RapC and PhrC (L. J. Core and M. Perego, Mol. Microbiol. 49:1509-1522, 2003). In fact, the RapF and PhrF pair of proteins acts synergistically with RapC and PhrC in the overall regulation of the ComA transcription factor. Since the transcription of the RapC- and RapF-encoding genes is positively regulated by their own target ComA, an autoregulatory circuit must exist for the competence transcription factor in order to modulate its activity. PMID:15968044

  4. Synergistic regulation of competence development in Bacillus subtilis by two Rap-Phr systems.

    Science.gov (United States)

    Bongiorni, Cristina; Ishikawa, Shu; Stephenson, Sophie; Ogasawara, Naotake; Perego, Marta

    2005-07-01

    The 11 Rap proteins of Bacillus subtilis comprise a conserved family of tetratricopeptide (TPR)-containing regulatory proteins. Their activity is inhibited by specific Phr pentapeptides produced from the product of phr genes through an export-import maturation process. We found that one of the proteins, namely RapF, is involved in the regulation of competence to DNA transformation. The ComA response regulator and transcription factor for initiation of competence development is the target of RapF. Specific binding of RapF to the carboxy-terminal DNA-binding domain of ComA inhibits the response regulator's ability to bind its target DNA promoters. The PhrF C-terminal pentapeptide, QRGMI, inhibits RapF activity. The activity of RapF and PhrF in regulating competence development is analogous to the previously described activity of RapC and PhrC (L. J. Core and M. Perego, Mol. Microbiol. 49:1509-1522, 2003). In fact, the RapF and PhrF pair of proteins acts synergistically with RapC and PhrC in the overall regulation of the ComA transcription factor. Since the transcription of the RapC- and RapF-encoding genes is positively regulated by their own target ComA, an autoregulatory circuit must exist for the competence transcription factor in order to modulate its activity.

  5. Binding of Multiple Rap1 Proteins Stimulates Chromosome Breakage Induction during DNA Replication.

    Directory of Open Access Journals (Sweden)

    Greicy H Goto

    2015-08-01

    Full Text Available Telomeres, the ends of linear eukaryotic chromosomes, have a specialized chromatin structure that provides a stable chromosomal terminus. In budding yeast Rap1 protein binds to telomeric TG repeat and negatively regulates telomere length. Here we show that binding of multiple Rap1 proteins stimulates DNA double-stranded break (DSB induction at both telomeric and non-telomeric regions. Consistent with the role of DSB induction, Rap1 stimulates nearby recombination events in a dosage-dependent manner. Rap1 recruits Rif1 and Rif2 to telomeres, but neither Rif1 nor Rif2 is required for DSB induction. Rap1-mediated DSB induction involves replication fork progression but inactivation of checkpoint kinase Mec1 does not affect DSB induction. Rap1 tethering shortens artificially elongated telomeres in parallel with telomerase inhibition, and this telomere shortening does not require homologous recombination. These results suggest that Rap1 contributes to telomere homeostasis by promoting chromosome breakage.

  6. JOINT ADVISORY APPEALS BOARD

    CERN Multimedia

    Human Resources Division

    2001-01-01

    The Joint Advisory Appeals Board was convened to examine the appeal lodged by Mr Neil Calder, Mrs Sudeshna Datta Cockerill, Mrs Andrée Fontbonne, Mrs Moniek Laurent and Mr Ulrich Liptow with regard to membership in the Pension Fund under the period with a Paid Associate contract, appeals dealt with on a collective basis. As the appellants have not objected, the report of the Board and the final decision of the Director-General are brought to the notice of the personnel in accordance with Article R VI 1.20 of the Staff Regulations. The relevant documents will therefore be posted on the notice boards of the Administration Building (N° 60) from 10 to 31 August 2001.

  7. 15 CFR 301.6 - Appeals.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Appeals. 301.6 Section 301.6 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE MISCELLANEOUS REGULATIONS INSTRUMENTS AND APPARATUS FOR EDUCATIONAL AND...

  8. 15 CFR 303.21 - Appeals.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Appeals. 303.21 Section 303.21 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE MISCELLANEOUS REGULATIONS WATCHES, WATCH MOVEMENTS AND...

  9. JOINT ADVISORY APPEALS BOARD

    CERN Multimedia

    Human Resources Division

    2002-01-01

    The Joint Advisory Appeals Board was convened to examine the appeal lodged by Mr Luc Vos with regard to advancement. As the appellant has not objected, the report of the Board and the final decision of the Director-General are brought to the notice of the personnel in accordance with Article R VI 1.20 of the Staff Regulations. The relevant documents will therefore be posted on the notice boards of the Administration Building (N° 60) from 14 to 28 June 2002. Human Resources Division Tel. 74128

  10. Joint Advisory Appeals Board

    CERN Multimedia

    2003-01-01

    The Joint Advisory Appeals Board was convened to examine the appeal lodged by Mr Poul Frandsen concerning his assimilation into the new career structure. As the appellant has not objected, the report of the Board and the final decision of the Director-General are brought to the notice of the personnel in accordance with Article R VI 1.20 of the Staff Regulations. The relevant documents will therefore be posted on the notice boards of the Administration Building (N° 60) from 13 to 24 January 2003. Human Resources Division Tel. 74128

  11. JOINT ADVISORY APPEALS BOARD

    CERN Multimedia

    Personnel Division

    1999-01-01

    The Joint Advisory Appeals Board was convened to examine the appeal lodged by Mr Joào Bento with regard to residential category. As the appellant has not objected, the recommendations of the Board and the final decision of the Director-General are brought to the notice of the personnel in accordance with Article RÊVIÊ1.20 of the Staff Regulations.The relevant documents will therefore be posted on the notice boards of the Administration Building (N¡ 60) from 29 October to 12 November 1999.Personnel DivisionTel. 74128

  12. Joint Advisory Appeals Board

    CERN Multimedia

    HR Department

    2006-01-01

    The Joint Advisory Appeals Board was convened to examine an appeal lodged by a member of the personnel with regard to advancement. The person concerned has requested that the report of the Board and the final decision of the Director-General be brought to the notice of the personnel in accordance with Article R VI 1.20 of the Staff Regulations. The relevant documents will therefore be posted on the notice boards of the Administration Building (No. 60) from 24 March to 10 April 2006. Human Resources Department Tel. 74128

  13. JOINT ADVISORY APPEALS BOARD

    CERN Multimedia

    Human Resources Division

    2001-01-01

    The Joint Advisory Appeals Board was convened to examine the appeal lodged by Mr Olivier Francis Martin with regard to indefinite contract. As the appellant has not objected, the report of the Board and the final decision of the Director-General are brought to the notice of the personnel in accordance with Article R VI 1.20 of the Staff Regulations. The relevant documents will therefore be posted on the notice boards of the Administration Building (N° 60) from 8 to 25 June 2001.

  14. JOINT ADVISORY APPEALS BOARD

    CERN Multimedia

    Human Resources Division

    2002-01-01

    The Joint Advisory Appeals Board was convened to examine the appeal lodged by Mr Jack Blanchard with regard to 'non recognition of specific functions'. As the appellant has not objected, the report of the Board and the final decision of the Director-General are brought to the notice of the personnel in accordance with Article R VI 1.20 of the Staff Regulations. The relevant documents will therefore be posted on the notice boards of the Administration Building (N° 60) from 12th to 26th April 2002. Human Resources Division Tel. 74128

  15. Joint Advisory Appeals Board

    CERN Multimedia

    2003-01-01

    The Joint Advisory Appeals Board was convened to examine the appeal lodged by Mrs Judith Igo-Kemenes concerning the application of procedures foreseen by Administrative Circular N§ 26 (Rev. 3). As the appellant has not objected, the report of the Board and the final decision of the Director-General are brought to the notice of the personnel in accordance with Article R VI 1.20 of the Staff Regulations. The relevant documents will therefore be posted on the notice boards of the Administration Building (N° 60) from 6 to 20 June 2003. Human Resources Division Tel. 74128

  16. Joint Advisory Appeals Board

    CERN Multimedia

    2004-01-01

    The Joint Advisory Appeals Board was convened to examine the appeal lodged by Mrs Maria DIMOU with regard to a periodic one-step increase. As the appellant has not objected, the report of the Board and the final decision of the Director-General are brought to the notice of the personnel in accordance with Article R VI 1.20 of the Staff Regulations. The relevant documents will therefore be posted on the notice boards of the Administration Building (N° 60) from 30 April to 14 May 2004. Human Resources Department Tel. 74128

  17. JOINT ADVISORY APPEALS BOARD

    CERN Multimedia

    Human Resources Division

    2001-01-01

    The Joint Advisory Appeals Board was convened to examine the appeal lodged by Mr Joël Lahaye with regard to non-resident allowance. As the appellant has not objected, the report of the Board and the final decision of the Director-General are brought to the notice of the personnel in accordance with Article R VI 1.20 of the Staff Regulations. The relevant documents will therefore be posted on the notice boards of the Administration Building (N° 60) from 18 May to 1st June 2001.

  18. JOINT ADVISORY APPEALS BOARD

    CERN Multimedia

    Human Resources Division

    2002-01-01

    The Joint Advisory Appeals Board was convened to examine the appeal lodged by Mr Bertrand Nicquevert with regard to the non-resident allowance. As the appellant has not objected, the report of the Board and the final decision of the Director-General are brought to the notice of the personnel in accordance with Article R VI 1.20 of the Staff Regulations. The relevant documents will therefore be posted on the notice boards of the Administration Building (N° 60) from 29 November to 13 December 2002. Human Resources Division Tel. 74128

  19. JOINT ADVISORY APPEALS BOARD

    CERN Multimedia

    Human Resources Division

    2002-01-01

    The Joint Advisory Appeals Board was convened to examine the appeal lodged by Mr Antonio Millich with regard to advancement. As the appellant has not objected, the report of the Board and the final decision of the Director-General are brought to the notice of the personnel in accordance with Article R VI 1.20 of the Staff Regulations. The relevant documents will therefore be posted on the notice boards of the Administration Building (N° 60) from 27 September to 11 October 2002. Human Resources Division Tel. 74128

  20. Joint Advisory Appeals Board

    CERN Multimedia

    Human Resources Department

    2005-01-01

    The Joint Advisory Appeals Board was convened to examine an appeal lodged by a member of the personnel with regard to a periodic one-step increase. As the appellant has not objected, the report of the Board and the final decision of the Director-General are brought to the notice of the personnel in accordance with Article R VI 1.20 of the Staff Regulations. The relevant documents will therefore be posted on the notice boards of the Administration Building (N° 60) from 1 to 15 April 2005. Human Resources Department Tel. 74128

  1. JOINT ADVISORY APPEALS BOARD

    CERN Multimedia

    Human Resources Division

    2002-01-01

    The Joint Advisory Appeals Board was convened to examine the appeal lodged by Mr Gert Jan Bossen with regard to dependent child allowance. As the appellant has not objected, the report of the Board and the final decision of the Director-General are brought to the notice of the personnel in accordance with Article R VI 1.20 of the Staff Regulations. The relevant documents will therefore be posted on the notice boards of the Administration Building (N° 60) from 1st to 15 March 2002. Human Resources Division Tel. 74128

  2. JOINT ADVISORY APPEALS BOARD

    CERN Multimedia

    Human Resources Division

    2002-01-01

    The Joint Advisory Appeals Board was convened to examine the appeal lodged by Mr Serge Peraire with regard to exceptional advancement. As the appellant has not objected, the report of the Board and the final decision of the Director-General are brought to the notice of the personnel in accordance with Article R VI 1.20 of the Staff Regulations. The relevant documents will therefore be posted on the notice boards of the Administration Building (N° 60) from 17 to 31 May 2002. Human Resources Division Tel. 74128

  3. Joint Advisory Appeals Board

    CERN Multimedia

    2003-01-01

    The Joint Advisory Appeals Board was convened to examine the appeal lodged by Mr Aloïs Girardoz with regard to classification and advancement. As the appellant has not objected, the Board's report and the Director-General's decision will be brought to the notice of the personnel in accordance with Article R VI 1.20 of the Staff Regulations. The relevant documents will therefore be posted on the notice boards of the Administration Building (N° 60) from 15 to 29 August 2003. Human Resources Division Tel. 74128

  4. Allegheny County Property Assessment Appeals

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — Lists property assessment appeals filed and heard with the Board of Property Assessment Appeals and Review (BPAAR) and the hearing results, for tax years 2015 to...

  5. Volumetric Analysis and Performance of Hot Mix Asphalt with Variable Rap Content

    Directory of Open Access Journals (Sweden)

    Arshad Ahmad Kamil

    2017-01-01

    Full Text Available Incorporating Reclaimed Asphalt Pavement (RAP to the asphalt concrete mixture for highway construction offer many benefits including energy consumption, conservation of natural resources and preservation of the environment to associated emissions. This paper presents a study on performance of Hot Mix Asphalt with variable RAP content. The study is carried out to evaluate the Marshall Properties and Performance of RAP-Asphalt mixes using conventional asphaltic concrete mix AC14. Marshall Mix Design Method was used to produce control mix (0% RAP and RAP-Asphalt mixes samples which consist of 15% RAP, 25% RAP and 35% RAP in accordance with Specifications for Road Works of Public Works Department, Malaysia. The Marshall Properties analysis was performed to ensure compliance with Marshall Requirements, The resilient modulus test was performed to measure the stiffness of the mixes while Modified Lottman test was conducted to evaluate the moisture susceptibility of these mixes. The results obtained showed that there were no substantial difference in Marshall Properties, moisture susceptibility and indirect tensile strength between RAP-Asphalt mixes with the control mix. The test results indicated that recycled mixes performed as good as the performance of conventional HMA in terms of moisture susceptibility and resilient modulus. It is recommended that further research be carried out for asphalt mixes containing more than 35% of RAP material.

  6. Performance Evaluation of Hot Mix Asphalt with Different Proportions of RAP Content

    Directory of Open Access Journals (Sweden)

    Kamil Arshad Ahmad

    2018-01-01

    Full Text Available Reclaimed Asphalt Pavement (RAP is old asphalt pavement that has been removed from a road by milling or full depth removal. The use of RAP in hot mix asphalt (HMA eliminates the need to dispose old asphalt pavements and conserves asphalt binders and aggregates, resulting in significant cost savings and benefits to society. This paper presents a study on HMA with different RAP proportions carried out to evaluate the volumetric properties and performance of asphalt mixes containing different proportions of RAP. Marshall Mix Design Method was used to produce control mix (0% RAP and asphalt mixes containing 15% RAP, 25% RAP and 35% RAP in accordance with Specifications for Road Works of Public Works Department, Malaysia for AC14 dense graded asphalt gradation. Volumetric analysis was performed to ensure that the result is compliance with specification requirements. The resilient modulus test was performed to measure the stiffness of the mixes while the Modified Lottman test was conducted to evaluate the moisture susceptibility of these mixes. The Hamburg wheel tracking test was used to evaluate the rutting performance of these mixes. The results obtained showed that there were no substantial difference in Marshall Properties, moisture susceptibility, resilient modulus and rutting resistance between asphalt mixes with RAP and the control mix. The test results indicated that recycled mixes performed as good as the performance of conventional HMA in terms of moisture susceptibility and resilient modulus. It is recommended that further research be carried out for asphalt mixes containing more than 35% RAP material.

  7. Performance Evaluation of Hot Mix Asphalt with Different Proportions of RAP Content

    Science.gov (United States)

    Kamil Arshad, Ahmad; Awang, Haryati; Shaffie, Ekarizan; Hashim, Wardati; Rahman, Zanariah Abd

    2018-03-01

    Reclaimed Asphalt Pavement (RAP) is old asphalt pavement that has been removed from a road by milling or full depth removal. The use of RAP in hot mix asphalt (HMA) eliminates the need to dispose old asphalt pavements and conserves asphalt binders and aggregates, resulting in significant cost savings and benefits to society. This paper presents a study on HMA with different RAP proportions carried out to evaluate the volumetric properties and performance of asphalt mixes containing different proportions of RAP. Marshall Mix Design Method was used to produce control mix (0% RAP) and asphalt mixes containing 15% RAP, 25% RAP and 35% RAP in accordance with Specifications for Road Works of Public Works Department, Malaysia for AC14 dense graded asphalt gradation. Volumetric analysis was performed to ensure that the result is compliance with specification requirements. The resilient modulus test was performed to measure the stiffness of the mixes while the Modified Lottman test was conducted to evaluate the moisture susceptibility of these mixes. The Hamburg wheel tracking test was used to evaluate the rutting performance of these mixes. The results obtained showed that there were no substantial difference in Marshall Properties, moisture susceptibility, resilient modulus and rutting resistance between asphalt mixes with RAP and the control mix. The test results indicated that recycled mixes performed as good as the performance of conventional HMA in terms of moisture susceptibility and resilient modulus. It is recommended that further research be carried out for asphalt mixes containing more than 35% RAP material.

  8. Assessment of transferring Sr-90 and Cs-137 in products of processing of seeds raps for getting raps' oil and biodiesel

    International Nuclear Information System (INIS)

    Yatsino, T.S.; Mironov, V.P.

    2009-01-01

    The objects of research are soil assays, seeds of raps, straw and the stalks selected on polluted radio nuclides of territory. The work purpose is to measure specific activity of strontium and cesium in assays, to calculate factors of transition Sr 90 and Sr 137 in products of processing of seeds of raps. (authors)

  9. Fatigue Durability Analysis of Collecting Rapping System in Electrostatic Precipitators under Impact Loading

    Directory of Open Access Journals (Sweden)

    Ali Akbar Lotfi Neyestanak

    2014-01-01

    Full Text Available Due to the importance of collecting rapping system in electrostatic precipitators (ESP and controlling the relevant damage under impact loading, fatigue durability of this system is analyzed in the present study based on the numerical and experimental results considering fatigue damage growth and vibration acceleration in the collecting system because of the successive impact of rapping hammers. By microscopic examination of the fracture surface of rapping hammer, beach marks obviously show typical fatigue failure in the rapping hammer arm. In addition, the microscopic examination of the cross section of the collecting plates indicates the corrosion voids which cause crack and eventually fatigue failure. The finite element method is applied to determine both the stress and concentration positions of dynamic stress on the rapping system under impact loading. The paper results can be utilized in system optimization and new material selection for the system by evaluating rapping system durability.

  10. How appealing is "Free"?

    OpenAIRE

    Corbett, Karina

    2007-01-01

    Many marketing strategies seem based on the notion that consumers respond more strongly to products that are being offered for free than a rational calculation would predict. Such a preference would be consistent with some existing research on ways that marketing takes advantage of irrational behavior, and research findings in mental accounting and budgeting might bear on the apparent irrational appeal of free. A series of experiments on people’s preferences produced mixed results. One exper...

  11. Cytoplasmic RAP1 mediates cisplatin resistance of non-small cell lung cancer.

    Science.gov (United States)

    Xiao, Lu; Lan, Xiaoying; Shi, Xianping; Zhao, Kai; Wang, Dongrui; Wang, Xuejun; Li, Faqian; Huang, Hongbiao; Liu, Jinbao

    2017-05-18

    Cytotoxic chemotherapy agents (e.g., cisplatin) are the first-line drugs to treat non-small cell lung cancer (NSCLC) but NSCLC develops resistance to the agent, limiting therapeutic efficacy. Despite many approaches to identifying the underlying mechanism for cisplatin resistance, there remains a lack of effective targets in the population that resist cisplatin treatment. In this study, we sought to investigate the role of cytoplasmic RAP1, a previously identified positive regulator of NF-κB signaling, in the development of cisplatin resistance in NSCLC cells. We found that the expression of cytoplasmic RAP1 was significantly higher in high-grade NSCLC tissues than in low-grade NSCLC; compared with a normal pulmonary epithelial cell line, the A549 NSCLC cells exhibited more cytoplasmic RAP1 expression as well as increased NF-κB activity; cisplatin treatment resulted in a further increase of cytoplasmic RAP1 in A549 cells; overexpression of RAP1 desensitized the A549 cells to cisplatin, and conversely, RAP1 depletion in the NSCLC cells reduced their proliferation and increased their sensitivity to cisplatin, indicating that RAP1 is required for cell growth and has a key mediating role in the development of cisplatin resistance in NSCLC cells. The RAP1-mediated cisplatin resistance was associated with the activation of NF-κB signaling and the upregulation of the antiapoptosis factor BCL-2. Intriguingly, in the small portion of RAP1-depleted cells that survived cisplatin treatment, no induction of NF-κB activity and BCL-2 expression was observed. Furthermore, in established cisplatin-resistant A549 cells, RAP1 depletion caused BCL2 depletion, caspase activation and dramatic lethality to the cells. Hence, our results demonstrate that the cytoplasmic RAP1-NF-κB-BCL2 axis represents a key pathway to cisplatin resistance in NSCLC cells, identifying RAP1 as a marker and a potential therapeutic target for cisplatin resistance of NSCLC.

  12. Effect of Rap1 binding on DNA distortion and potassium permanganate hypersensitivity.

    Science.gov (United States)

    Le Bihan, Yann-Vaï; Matot, Béatrice; Pietrement, Olivier; Giraud-Panis, Marie-Josèphe; Gasparini, Sylvaine; Le Cam, Eric; Gilson, Eric; Sclavi, Bianca; Miron, Simona; Le Du, Marie-Hélène

    2013-03-01

    Repressor activator protein 1 (Rap1) is an essential factor involved in transcription and telomere stability in the budding yeast Saccharomyces cerevisiae. Its interaction with DNA causes hypersensitivity to potassium permanganate, suggesting local DNA melting and/or distortion. In this study, various Rap1-DNA crystal forms were obtained using specifically designed crystal screens. Analysis of the DNA conformation showed that its distortion was not sufficient to explain the permanganate reactivity. However, anomalous data collected at the Mn edge using a Rap1-DNA crystal soaked in potassium permanganate solution indicated that the DNA conformation in the crystal was compatible with interaction with permanganate ions. Sequence-conservation analysis revealed that double-Myb-containing Rap1 proteins all carry a fully conserved Arg580 at a position that may favour interaction with permanganate ions, although it is not involved in the hypersensitive cytosine distortion. Permanganate reactivity assays with wild-type Rap1 and the Rap1[R580A] mutant demonstrated that Arg580 is essential for hypersensitivity. AFM experiments showed that wild-type Rap1 and the Rap1[R580A] mutant interact with DNA over 16 successive binding sites, leading to local DNA stiffening but not to accumulation of the observed local distortion. Therefore, Rap1 may cause permanganate hypersensitivity of DNA by forming a pocket between the reactive cytosine and Arg580, driving the permanganate ion towards the C5-C6 bond of the cytosine.

  13. Sequence and organization of the rhoptry-associated-protein-1 (rap-1) locus for the sheep hemoprotozoan Babesia sp. BQ1 Lintan (B. motasi phylogenetic group).

    Science.gov (United States)

    Niu, Qingli; Bonsergent, Claire; Guan, Guiquan; Yin, Hong; Malandrin, Laurence

    2013-11-15

    Babesiosis is a frequent infection of animals worldwide by tick borne pathogen Babesia, and several species are responsible for ovine babesiosis. Recently, several Babesia motasi-like isolates were described in sheep in China. In this study, we sequenced the multigenic rap-1 gene locus of one of these isolates, Babesia sp. BQ1 Lintan. The RAP-1 proteins are involved in the process of red blood cells invasion and thus represent a potential target for vaccine development. A complex composition and organization of the rap-1 locus was discovered with: (1) the presence of 3 different types of rap-1 sequences (rap-1a, rap-1b and rap-1c); (2) the presence of multiple copies of rap-1a and rap-1b; (3) polymorphism among the rap-1a copies, with two classes (named rap-1a61 and rap-1a67) having a similarity of 95.7%, each class represented by two close variants; (4) polymorphism between rap-1a61-1 and rap-1a61-2 limited to three nucleotide positions; (5) a difference of eight nucleotides between rap-1a67-1 and rap-1a67-2 from position 1270 to the putative stop site of rap-1a67-1 which might produce two putative proteins of slightly different sizes; (6) the ratio of rap-1a copies corresponding to one rap-1a67, one rap-1a61-1 and one rap-1a61-2; (7) the presence of three different intergenic regions separating rap-1a, rap-1b and rap-1c; (8) interspacing of the rap-1a copies with rap-1b copies; and (9) the terminal position of rap-1c in the locus. A 31kb locus composed of 6 rap-1a sequences interspaced with 5 rap-1b sequences and with a terminal rap-1c copy was hypothesized. A strikingly similar sequence composition (rap-1a, rap-1b and rap-1c), as well as strong gene identities and similar locus organization with B. bigemina were found and highlight the conservation of synteny at this locus in this phylogenetic clade. Copyright © 2013 Elsevier B.V. All rights reserved.

  14. Investigation on performances of asphalt mixtures made with Reclaimed Asphalt Pavement: Effects of interaction between virgin and RAP bitumen

    Directory of Open Access Journals (Sweden)

    Luca Noferini

    2017-07-01

    Full Text Available According to most recent surveys, the European area produced 265 mil tonnes of asphalt for road applications in 2014. In the same year, the amount of available RAP was more than 50 mil tonnes. The use of RAP in new blended mixes reduces the need of neat bitumen, making RAP recycling economically attractive. Despite the economic and environmental benefits, road authorities tend to limit the use of RAP in asphalt mixes due to uncertainty about field performances. The present study focuses on the interaction between neat and RAP bitumen in asphalt mixes made with different RAP content. The effects of RAP on physical and rheological properties of the final bituminous blend were investigated. This study is part of a wider research, where a specific type of asphalt mixture was produced with different RAP contents being 10%, 20% and 30% by mass of the mix. Bitumen was extracted and recovered from asphalt mixes, then it was subjected to the following laboratory tests: standard characterization, dynamic viscosity and rheological analysis with DSR. Findings showed that the effects of RAP bitumen on the final blend varied in proportion to RAP content. A threshold value of RAP content was found, below which bitumen was not subjected to significant changes in physical and rheological properties. Practical implications on production methods and paving of RAP mixes are also proposed. Keywords: Reclaimed Asphalt Pavement (RAP, Recycling, Bitumen blending, Bitumen rheology

  15. Appeal to the ILOAT

    CERN Multimedia

    Association du personnel

    2007-01-01

    In the official CERN Bulletin, for weeks beginning 2nd and 9th April 2007, it read that on 7 March the Governing Board of the Pension Fund noted with satisfaction that the appeal lodged by a beneficiary against the CERN Council decision to index his pension at 0% for the year 2005 had been rejected by the ILO Administrative Tribunal. Whether the enthusiasm is of the Governing Board or of the writer, it reduces the importance of the matter and is inopportune, since it concerns an issue as complicated and sensitive as the maintaining of the purchasing power of the replacement income of retired staff that their pensions represent.

  16. Retrotransposition and mutation events yield Rap1 GTPases with differential signalling capacity

    Directory of Open Access Journals (Sweden)

    Penzkofer Tobias

    2010-02-01

    Full Text Available Abstract Background Retrotransposition of mRNA transcripts gives occasionally rise to functional retrogenes. Through acquiring tempero-spatial expression patterns distinct from their parental genes and/or functional mutations in their coding sequences, such retrogenes may in principle reshape signalling networks. Results Here we present evidence for such a scenario, involving retrogenes of Rap1 belonging to the Ras family of small GTPases. We identified two murine and one human-specific retrogene of Rap1A and Rap1B, which encode proteins that differ by only a few amino acids from their parental Rap1 proteins. Markedly, human hRap1B-retro and mouse mRap1A-retro1 acquired mutations in the 12th and 59th amino acids, respectively, corresponding to residues mutated in constitutively active oncogenic Ras proteins. Statistical and structural analyses support a functional evolution scenario, where Rap1 isoforms of retrogenic origin are functionally distinct from their parental proteins. Indeed, all retrogene-encoded GTPases have an increased GTP/GDP binding ratio in vivo, indicating that their conformations resemble that of active GTP-bound Rap1. We furthermore demonstrate that these three Rap1 isoforms exhibit distinct affinities for the Ras-binding domain of RalGDS. Finally, when tested for their capacity to induce key cellular processes like integrin-mediated cell adhesion or cell spreading, marked differences are seen. Conclusions Together, these data lend strong support for an evolution scenario, where retrotransposition and subsequent mutation events generated species-specific Rap1 isoforms with differential signaling potential. Expression of the constitutively active human Rap1B-retro in cells like those derived from Ramos Burkitt's lymphoma and bone marrow from a patient with myelodysplastic syndrome (MDS warrants further investigation into its role in disease development.

  17. From Rage to Rap and Prison to Print:

    Directory of Open Access Journals (Sweden)

    Josephine Metcalf

    2009-11-01

    Full Text Available 1. IntroductionBy the late 1980s, while thousands of former gang members were either dead or incarcerated, their legacy and the gang subculture was being celebrated and commodified through gangsta rap music and videos, film and fashion. In the early 1990s this lucrative cultural trend sparked interest from potential authors and publishers. Such literary attention was partially fuelled by a public fascination with life in the ghettos following the 1992 Los Angeles (LA riots, resulting in a ne...

  18. Literature review : performance of RAP/RAS mixes and new direction.

    Science.gov (United States)

    2014-04-01

    In the last several years reclaimed asphalt pavement (RAP) and recycled asphalt shingles (RAS) have been : widely used in asphalt mixes in Texas. The use of RAP/RAS can significantly reduce the initial cost of : asphalt mixtures, conserve energy, and...

  19. Whats the Rap about Ecstasy? Popular Music Lyrics and Drug Trends among American Youth

    Science.gov (United States)

    Diamond, Sarah; Bermudez, Rey; Schensul, Jean

    2006-01-01

    Trends in ecstasy use in America during the past decade were reflected in mainstream, American rap-music lyrics between 1996 and 2003. Drawing on communication and cultural studies theory, this article provides a content analysis of 69 rap songs mentioning the club drug ecstasy. The songs are coded according to whether they contain positive, mixed…

  20. Affiliation and Alienation: Hip-Hop, Rap, and Urban Science Education

    Science.gov (United States)

    Emdin, Christopher

    2010-01-01

    The critiques of rap artists and other participants in hip-hop culture provide data for teachers and researchers to investigate the attitudes of US urban youth towards schooling. This study explores the complex relationships between hip-hop and science education by examining how rap lyrics project beliefs about schooling, the relevance of existing…

  1. Thermodynamics between RAP/RAS and virgin aggregates during asphalt concrete production : a literature review.

    Science.gov (United States)

    2015-09-01

    In hot-mix asphalt (HMA) plants, virgin aggregates are heated and dried separately before being mixed with : RAP/RAS and virgin asphalt binder. RAP/RAS materials are not heated or dried directly by a burner to avoid : burning of aged binder coating o...

  2. Species-Specific Expression of Full-Length and Alternatively Spliced Variant Forms of CDK5RAP2.

    Directory of Open Access Journals (Sweden)

    John S Y Park

    Full Text Available CDK5RAP2 is one of the primary microcephaly genes that are associated with reduced brain size and mental retardation. We have previously shown that human CDK5RAP2 exists as a full-length form (hCDK5RAP2 or an alternatively spliced variant form (hCDK5RAP2-V1 that is lacking exon 32. The equivalent of hCDK5RAP2-V1 has been reported in rat and mouse but the presence of full-length equivalent hCDK5RAP2 in rat and mouse has not been examined. Here, we demonstrate that rat expresses both a full length and an alternatively spliced variant form of CDK5RAP2 that are equivalent to our previously reported hCDK5RAP2 and hCDK5RAP2-V1, repectively. However, mouse expresses only one form of CDK5RAP2 that is equivalent to the human and rat alternatively spliced variant forms. Knowledge of this expression of different forms of CDK5RAP2 in human, rat and mouse is essential in selecting the appropriate model for studies of CDK5RAP2 and primary microcephaly but our findings further indicate the evolutionary divergence of mouse from the human and rat species.

  3. Composite mechanisms for improving Bubble Rap in delay tolerant networks

    Directory of Open Access Journals (Sweden)

    Sweta Jain

    2014-01-01

    Full Text Available Delay tolerant networks (DTNs are a subset of mobile ad hoc networks where connections are sparse and intermittent. This often results in a network graph which is rarely connected which introduces a challenge in message forwarding because of a lack of end-to-end connectivity towards the destination. Recently, social-based forwarding algorithms are gaining popularity because of the social nature displayed by the node movements in a DTN, especially in application areas like the pocket switched networks. The social-based metrics like community, similarity, centrality etc. are used to determine the carrier to which a node has to forward its message. Composite methods are used to improve the performance of Bubble Rap social-based forwarding algorithm. In the proposed mechanism, a new social metric termed ‘friendship’ has been introduced along with a time-to-live (TTL-based ‘threshold’ and acknowledgement (ACK IDs. Real trace data and working day movement models are used for simulations in the opportunistic network environment simulator to demonstrate that the proposed algorithm gives better delivery ratio than the original Bubble Rap algorithm.

  4. 25 CFR 700.247 - Appeals.

    Science.gov (United States)

    2010-04-01

    ... envelope containing the notice of appeal and the face of the notice shall bear the legend “FREEDOM OF INFORMATION APPEAL”. The failure of an appeal to bear such a legend will not disqualify an appeal from...

  5. Identification of the functional domains of the telomere protein Rap1 in Schizosaccharomyces pombe.

    Directory of Open Access Journals (Sweden)

    Ikumi Fujita

    Full Text Available The telomere at the end of a linear chromosome plays crucial roles in genome stability. In the fission yeast Schizosaccharomyces pombe, the Rap1 protein, one of the central players at the telomeres, associates with multiple proteins to regulate various telomere functions, such as the maintenance of telomere DNA length, telomere end protection, maintenance of telomere heterochromatin, and telomere clustering in meiosis. The molecular bases of the interactions between Rap1 and its partners, however, remain largely unknown. Here, we describe the identification of the interaction domains of Rap1 with its partners. The Bqt1/Bqt2 complex, which is required for normal meiotic progression, Poz1, which is required for telomere length control, and Taz1, which is required for the recruitment of Rap1 to telomeres, bind to distinct domains in the C-terminal half of Rap1. Intriguingly, analyses of a series of deletion mutants for rap1(+ have revealed that the long N-terminal region (1-456 a.a. [amino acids] of Rap1 (full length: 693 a.a. is not required for telomere DNA length control, telomere end protection, and telomere gene silencing, whereas the C-terminal region (457-693 a.a. containing Poz1- and Taz1-binding domains plays important roles in those functions. Furthermore, the Bqt1/Bqt2- and Taz1-binding domains are essential for normal spore formation after meiosis. Our results suggest that the C-terminal half of Rap1 is critical for the primary telomere functions, whereas the N-terminal region containing the BRCT (BRCA1 C-terminus and Myb domains, which are evolutionally conserved among the Rap1 family proteins, does not play a major role at the telomeres.

  6. The Effect of Rap/Hip-Hop Music on Young Adult Smoking: An Experimental Study.

    Science.gov (United States)

    Harakeh, Zeena; Bogt, Tom F M Ter

    2018-02-16

    Music may influence young people's behavior through its lyrics. Substance use references occur more frequently in rap/hip-hop than in other music genres. The aim was to examine whether the exposure to rap/hip-hop lyrics referring to substance use affected cigarette smoking. An experiment with a 3-group between subject design was conducted among 74 daily-smoking young adults ranging in age from 17 to 25 years old. Three conditions were tested in a mobile lab (camper vehicle) from May to December 2011, i.e., regular chart pop music (N = 28), rap/hip-hop with non-frequent references to substance use (N = 24), and rap/hip-hop with frequent references to substance use (N = 22). One-way ANOVA showed that participants listening to substance use infused rap/hip-hop songs felt significantly less pleasant, liked the songs less, and comprehended the songs less compared to participants listening to pop songs. Poisson loglinear analyses revealed that compared to the pop music condition, none of the two rap/hip-hop music conditions had a significant effect on acute smoking. Thus, contrary to expectations, the two different rap/hip-hop conditions did not have a significantly different effect on acute smoking. Listening to rap/hip-hop, even rap hip/hop with frequent referrals to substance use (primarily alcohol and drug use, and general smoking referrals), does not seem to encourage cigarette smoking among Dutch daily-smoking young adults, at least short term.

  7. Rap Music Use, Perceived Peer Behavior, and Sexual Initiation Among Ethnic Minority Youth.

    Science.gov (United States)

    Johnson-Baker, Kimberly A; Markham, Christine; Baumler, Elizabeth; Swain, Honora; Emery, Susan

    2016-03-01

    Research shows that rap music use is associated with risky sexual behavior in ethnic minority youth; however, it is unknown whether rap music use impacts sexual initiation specifically and, if so, which factors mediate this impact. Thus, we investigated the longitudinal relationship between hours spent listening to rap music in seventh grade and sexual initiation in ninth grade. We also examined the role of perceived peer sexual behavior as a potential mediator of this relationship. We analyzed data from students (n = 443) enrolled in a school-based randomized controlled trial of a sexual health education curriculum collected at baseline and at 18-month follow-up. Rap music use and perceived peer sexual behavior were assessed in seventh grade, whereas sexual initiation was assessed in ninth grade. Univariate, multivariate, and mediation analyses were conducted. At baseline, rap music use was significantly associated with race/ethnicity, parental music rules, and sexual behavior, but not with gender or parental education. Rap music use was a significant predictor of sexual initiation on univariate analysis but not multivariate analysis. Mediation analysis showed that the association between hours spent listening to rap music and sexual initiation was significantly mediated by perceived peer sexual behavior. Rap music use in early adolescence significantly impacts sexual initiation in late adolescence, partially mediated by perceived peer sexual behavior. More research is needed to understand how rap music influences perceptions of peer sexual behavior, which, in turn, influence early sexual initiation. Copyright © 2016 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

  8. Two biomarker-directed randomized trials in European and Chinese patients with nonsmall-cell lung cancer: the BRCA1-RAP80 Expression Customization (BREC) studies.

    Science.gov (United States)

    Moran, T; Wei, J; Cobo, M; Qian, X; Domine, M; Zou, Z; Bover, I; Wang, L; Provencio, M; Yu, L; Chaib, I; You, C; Massuti, B; Song, Y; Vergnenegre, A; Lu, H; Lopez-Vivanco, G; Hu, W; Robinet, G; Yan, J; Insa, A; Xu, X; Majem, M; Chen, X; de Las Peñas, R; Karachaliou, N; Sala, M A; Wu, Q; Isla, D; Zhou, Y; Baize, N; Zhang, F; Garde, J; Germonpre, P; Rauh, S; ALHusaini, H; Sanchez-Ronco, M; Drozdowskyj, A; Sanchez, J J; Camps, C; Liu, B; Rosell, R

    2014-11-01

    In a Spanish Lung Cancer Group (SLCG) phase II trial, the combination of BRCA1 and receptor-associated protein 80 (RAP80) expression was significantly associated with outcome in Caucasian patients with nonsmall-cell lung cancer (NSCLC). The SLCG therefore undertook an industry-independent collaborative randomized phase III trial comparing nonselected cisplatin-based chemotherapy with therapy customized according to BRCA1/RAP80 expression. An analogous randomized phase II trial was carried out in China under the auspices of the SLCG to evaluate the effect of BRCA1/RAP80 expression in Asian patients. Eligibility criteria included stage IIIB-IV NSCLC and sufficient tumor specimen for molecular analysis. Randomization to the control or experimental arm was 1 : 1 in the SLCG trial and 1 : 3 in the Chinese trial. In both trials, patients in the control arm received docetaxel/cisplatin; in the experimental arm, patients with low RAP80 expression received gemcitabine/cisplatin, those with intermediate/high RAP80 expression and low/intermediate BRCA1 expression received docetaxel/cisplatin, and those with intermediate/high RAP80 expression and high BRCA1 expression received docetaxel alone. The primary end point was progression-free survival (PFS). Two hundred and seventy-nine patients in the SLCG trial and 124 in the Chinese trial were assessable for PFS. PFS in the control and experimental arms in the SLCG trial was 5.49 and 4.38 months, respectively [log rank P = 0.07; hazard ratio (HR) 1.28; P = 0.03]. In the Chinese trial, PFS was 4.74 and 3.78 months, respectively (log rank P = 0.82; HR 0.95; P = 0.82). Accrual was prematurely closed on the SLCG trial due to the absence of clinical benefit in the experimental over the control arm. However, the BREC studies provide proof of concept that an international, nonindustry, biomarker-directed trial is feasible. Thanks to the groundwork laid by these studies, we expect that ongoing further research on alternative biomarkers to

  9. EEG and MEG source localization using recursively applied (RAP) MUSIC

    Energy Technology Data Exchange (ETDEWEB)

    Mosher, J.C. [Los Alamos National Lab., NM (United States); Leahy, R.M. [University of Southern California, Los Angeles, CA (United States). Signal and Image Processing Inst.

    1996-12-31

    The multiple signal characterization (MUSIC) algorithm locates multiple asynchronous dipolar sources from electroencephalography (EEG) and magnetoencephalography (MEG) data. A signal subspace is estimated from the data, then the algorithm scans a single dipole model through a three-dimensional head volume and computes projections onto this subspace. To locate the sources, the user must search the head volume for local peaks in the projection metric. Here we describe a novel extension of this approach which we refer to as RAP (Recursively APplied) MUSIC. This new procedure automatically extracts the locations of the sources through a recursive use of subspace projections, which uses the metric of principal correlations as a multidimensional form of correlation analysis between the model subspace and the data subspace. The dipolar orientations, a form of `diverse polarization,` are easily extracted using the associated principal vectors.

  10. Appeals in Special Adminisrtative Domains

    Directory of Open Access Journals (Sweden)

    Vuk CUCIĆ

    2011-10-01

    Full Text Available This paper is preceded by another work on the administrative appeal in Serbian law, as prescribed by General Administrative Proceeding Act. It builds upon that by describing and analyzing the most often modifications made to the general regime of the administrative appeal in various policy areas. It furthermore depicts special administrative control mechanisms, different from the administrative appeal, that exist in the fields of public procurement, education and broadcasting. These two articles should conclude the normative analysis of the system of administrative appeal and its counterpart administrative recourses. Normative analysis should further allow empirical research of the efficiency thereof and enable drawing of conclusions on respective features of the appellate proceeding that provide the best results in protection of the legality and private and public interests.

  11. 25 CFR 11.911 - Appeal.

    Science.gov (United States)

    2010-04-01

    ... AFFAIRS, DEPARTMENT OF THE INTERIOR LAW AND ORDER COURTS OF INDIAN OFFENSES AND LAW AND ORDER CODE Children's Court § 11.911 Appeal. (a) For purposes of appeal, a record of the proceedings shall be made... the party seeking the appeal. (b) Any party to a children's court hearing may appeal a final order or...

  12. Le jeu incertain des générations An uncertain play of generations. How rap artists settle as a professional group within the French music industry

    Directory of Open Access Journals (Sweden)

    Karim Hammou

    2011-11-01

    Full Text Available Le rap en français peut être aujourd’hui considéré comme un univers professionnel établi, tout en étant une innovation relativement récente. Cet article montre que sa pérennisation est le fruit des rapports complexes entre trois générations d’artistes, et entre ces générations et les acteurs des industries musicales. Il s’appuie en particulier sur l’examen des conventions discographiques (refrains, collaborations, producteurs… privilégiées par les rappeurs qui se succèdent en France de 1990 à 2004. Une première génération émerge en 1990-1993 d’un pari ponctuel des grandes maisons de disques sur le rap. Une nouvelle génération de rappeurs, celle de 1994-1997, ne bénéfice pas d’un même contexte. Les clivages internes qui la traversent, liés à la médiation des radios, éclipsent ses tentatives de distinction à l’égard de la première génération. Dans le jeu de rivalités et de collaborations entre ces fractions de la scène rap naît un système d’accréditation informelle entre rappeurs qui marginalise une frange de la deuxième génération. La pratique professionnelle du rap connaît alors une autonomie relative, descriptible comme une concession au sein de l’industrie du disque. Enfin, les artistes qui accèdent à la notoriété à partir de 1998 se distinguent par leur rapport d’aspirant à l’égard d’un monde social désormais perçu comme prévisible. L’étude d’un tel processus d’intégration d’une nouvelle technique d’interprétation vocale dans les industries musicales françaises révèle la pertinence de l’outil conceptuel des générations sociologiques pour saisir le renouvellement des univers artistiques et des dynamiques professionnelles.French rap music is now an established industry, although it is still a recent innovation. This paper shows that its establishment is the result of the complex relationship between three generations of artists, oligopolistic

  13. Fundamental evaluation of the interaction between RAS/RAP and virgin asphalt binders.

    Science.gov (United States)

    2017-08-01

    A comprehensive laboratory testing program was conducted in this research project to examine the blending between reclaimed asphalt pavement (RAP)/recycled asphalt shingles (RAS) and virgin asphalt binders and to evaluate the factors that may affect ...

  14. Influence of slope and gradation on rip rap stability and degradation mechanisms

    International Nuclear Information System (INIS)

    Lefebvre, G.; Rohan, K.; Belfahdel, M. B.

    1997-01-01

    A major investigation was undertaken at the La Grande hydroelectric complex with some 220 dikes and dams to study rip rap stability and repair. Degradation mechanisms were also studied under laboratory conditions to verify the main field study conclusions and to test different repair techniques. The result of both laboratory and field observation was that rip rap gradation has only marginal effect on slope stability and degradation mechanisms. On the other hand, the inclusion of even a small fraction of fine blocks (as little as 10 per cent) into the rip rap was shown to be very detrimental to the stability of steep rip rap but only marginally effective on flat slopes. 15 refs., 8 figs

  15. Laboratory testing and economic analysis of high RAP warm mixed asphalt.

    Science.gov (United States)

    2009-03-24

    This report contains laboratory testing, economic analysis, literature review, and information obtained from multiple producers throughout the state of Mississippi regarding the use of high RAP (50 % to 100%) mixtures containing warm mix additives. T...

  16. Improving Quality Control of Asphalt Pavement with RAP Using a Portable Infrared Spectroscopy Device

    Science.gov (United States)

    2016-04-01

    This project has investigated the effectiveness of a Portable Infrared Spectrometer (PIRS) device in estimating percent of Reclaimed Asphalt Pavement (RAP) and its contribution into oxidative aging of a new asphalt mixture immediately after productio...

  17. Neuronal Rap1 regulates energy balance, glucose homeostasis, and leptin actions

    OpenAIRE

    Kaneko, Kentaro; Xu, Pingwen; Cordonier, Elizabeth L.; Chen, Siyu S.; Ng, Amy; Xu, Yong; Morozov, Alexei; Fukuda, Makoto

    2016-01-01

    The central nervous system (CNS) contributes to obesity and metabolic disease; however, the underlying neurobiological pathways remain to be fully established. Here we show that the small GTPase Rap1 is expressed in multiple hypothalamic nuclei that control whole-body metabolism and is activated in high-fat diet (HFD)-induced obesity. Genetic ablation of CNS Rap1 protects mice from dietary obesity, glucose imbalance, and insulin resistance in the periphery and from HFD-induced neuropathologic...

  18. Analysis of the usage of rubberized asphalt in hot mix asphalt using Reclaimed Asphalt Pavement (RAP)

    Science.gov (United States)

    Dwidarma Nataadmadja, Adelia; Prahara, Eduardi; Sumbung, Pierre Christian

    2017-12-01

    There has been an increasing demand in using more environmentally friendly materials in pavement construction. One of the alternative materials that have been widely used is the Reclaimed Asphalt Pavement (RAP) aggregates. The RAP aggregates are derived from the crushed and screened pavement materials that contain asphalt and aggregates. This material is usually combined with natural aggregates and virgin asphalt binder to construct a new pavement. There have been numerous positive feedbacks in using this material although RAP aggregates also have certain weaknesses, such as questionable interaction between virgin and recycled materials and increased stiffness of RAP binder. Moreover, there has been a push on using rubber as an additive to asphalt binder to improve the welfare of rubber farmers. This research combines the usage of both latex and RAP as the ingredients to design hot mix asphalt (HMA) as latex could help in improving the flexibility of HMA and the interaction between the virgin and recycled materials. The main objective of this research is to find a suitable percentage of RAP aggregates to be used in HMA with certain percentage of latex as the binder additive.

  19. Rap phosphatase of virulence plasmid pXO1 inhibits Bacillus anthracis sporulation.

    Science.gov (United States)

    Bongiorni, Cristina; Stoessel, Ricarda; Shoemaker, Dorinda; Perego, Marta

    2006-01-01

    This study shows that the Bacillus anthracis pXO1 virulence plasmid carries a Rap-Phr system, BXA0205, which regulates sporulation initiation in this organism. The BXA0205Rap protein was shown to dephosphorylate the Spo0F response regulator intermediate of the phosphorelay signal transduction system that regulates the initiation of the developmental pathway in response to environmental, metabolic, and cell cycle signals. The activity of the Rap protein was shown to be inhibited by the carboxy-terminal pentapeptide generated through an export-import processing pathway from the associated BXA0205Phr protein. Deregulation of the Rap activity by either overexpression or lack of the Phr pentapeptide resulted in severe inhibition of sporulation. Five additional Rap-Phr encoding systems were identified on the chromosome of B. anthracis, one of which, BA3790-3791, also affected sporulation initiation. The results suggest that the plasmid-borne Rap-Phr system may provide a selective advantage to the virulence of B. anthracis.

  20. Rap Phosphatase of Virulence Plasmid pXO1 Inhibits Bacillus anthracis Sporulation†

    Science.gov (United States)

    Bongiorni, Cristina; Stoessel, Ricarda; Shoemaker, Dorinda; Perego, Marta

    2006-01-01

    This study shows that the Bacillus anthracis pXO1 virulence plasmid carries a Rap-Phr system, BXA0205, which regulates sporulation initiation in this organism. The BXA0205Rap protein was shown to dephosphorylate the Spo0F response regulator intermediate of the phosphorelay signal transduction system that regulates the initiation of the developmental pathway in response to environmental, metabolic, and cell cycle signals. The activity of the Rap protein was shown to be inhibited by the carboxy-terminal pentapeptide generated through an export-import processing pathway from the associated BXA0205Phr protein. Deregulation of the Rap activity by either overexpression or lack of the Phr pentapeptide resulted in severe inhibition of sporulation. Five additional Rap-Phr encoding systems were identified on the chromosome of B. anthracis, one of which, BA3790-3791, also affected sporulation initiation. The results suggest that the plasmid-borne Rap-Phr system may provide a selective advantage to the virulence of B. anthracis. PMID:16385039

  1. Project risk and appeals in U.S. Forest Service planning

    International Nuclear Information System (INIS)

    Stern, Marc J.; Predmore, S. Andrew; Morse, Wayde C.; Seesholtz, David N.

    2013-01-01

    The National Environmental Policy Act (NEPA) requires U.S. Forest Service planning processes to be conducted by interdisciplinary teams of resource specialists to analyze and disclose the likely environmental impacts of proposed natural resource management actions on Forest Service lands. Multiple challenges associated with these processes have been a source of frustration for the agency. One of these challenges involves administrative appeals through which public entities can challenge a Forest Service decision following a NEPA process. These appeals instigate an internal review process and can result in an affirmation of the Forest Service decision, a reversal of that decision, or additional work that re-initiates all or part of the NEPA process. We examine the best predictors of appeals and their outcomes on a representative sample of 489 Forest Service NEPA processes that were decided between 2007 and 2009. While certain factors associated with pre-existing social contexts (such as a history of controversy) or pre-determined elements of a proposed action (such as the extraction of forest products) predispose certain processes to a higher risk of appeals, other practices and process-related strategies within the control of the agency also appear to bear meaningful influence on the occurrence of appeals and their outcomes. Appeals and their outcomes were most strongly related to programmatic, structural (turnover of personnel in particular), and relationship risks (both internal and external) within the processes, suggesting the need for greater focus within the agency on cultivating positive internal and external relationships to manage the risk of appeals. -- Highlights: ► We examined appeals and their outcomes on 489 U.S. Forest Service NEPA processes. ► Project type, context, team turnover, and personal relationships predicted appeals. ► External relationship management and staff turnover best predicted appeal outcomes. ► Positive internal and

  2. Project risk and appeals in U.S. Forest Service planning

    Energy Technology Data Exchange (ETDEWEB)

    Stern, Marc J., E-mail: mjstern@vt.edu [Department of Forest Resources and Environmental Conservation, Virginia Tech, 304 Cheatham Hall (0324), Blacksburg, VA 24061 (United States); Predmore, S. Andrew, E-mail: spred2@uis.edu [Department of Environmental Studies, University of Illinois-Springfield, Public Affairs Center, Room 314, Springfield, IL 62703 (United States); Morse, Wayde C., E-mail: morsewc@auburn.edu [School of Forestry and Wildlife Sciences, Auburn University, 3301 Forestry and Wildlife Bldg., Auburn, AL 36849 (United States); Seesholtz, David N., E-mail: dseesholtz@fs.fed.us [Focused Science Delivery Program, Pacific Northwest Research Station, USDA Forest Service, 1249S Vinnell Way, Suite 200, Boise, ID 83709 (United States)

    2013-09-15

    The National Environmental Policy Act (NEPA) requires U.S. Forest Service planning processes to be conducted by interdisciplinary teams of resource specialists to analyze and disclose the likely environmental impacts of proposed natural resource management actions on Forest Service lands. Multiple challenges associated with these processes have been a source of frustration for the agency. One of these challenges involves administrative appeals through which public entities can challenge a Forest Service decision following a NEPA process. These appeals instigate an internal review process and can result in an affirmation of the Forest Service decision, a reversal of that decision, or additional work that re-initiates all or part of the NEPA process. We examine the best predictors of appeals and their outcomes on a representative sample of 489 Forest Service NEPA processes that were decided between 2007 and 2009. While certain factors associated with pre-existing social contexts (such as a history of controversy) or pre-determined elements of a proposed action (such as the extraction of forest products) predispose certain processes to a higher risk of appeals, other practices and process-related strategies within the control of the agency also appear to bear meaningful influence on the occurrence of appeals and their outcomes. Appeals and their outcomes were most strongly related to programmatic, structural (turnover of personnel in particular), and relationship risks (both internal and external) within the processes, suggesting the need for greater focus within the agency on cultivating positive internal and external relationships to manage the risk of appeals. -- Highlights: ► We examined appeals and their outcomes on 489 U.S. Forest Service NEPA processes. ► Project type, context, team turnover, and personal relationships predicted appeals. ► External relationship management and staff turnover best predicted appeal outcomes. ► Positive internal and

  3. 19 CFR 115.17 - Appeal to Commissioner of Customs.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Appeal to Commissioner of Customs. 115.17 Section 115.17 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CARGO CONTAINER AND ROAD VEHICLE CERTIFICATION PURSUANT TO INTERNATIONAL CUSTOMS...

  4. The French Accelerometer Network (RAP): Current state in 2007

    International Nuclear Information System (INIS)

    Gueguen, P.; Bard, P.-Y.; Pequegnat, C.; Souriau, A.; Dominique, P.; Regnier, M.

    2007-01-01

    France is a country of moderate seismicity but, due to dense urbanized and industrial areas, the seismic risk is significant. Furthermore, recent developments in numerical and semi-empirical methods requires a good knowledge of several parameters. The mission of the French accelerometer network programme (RAP-Reseau Accelerometrique Permanent) is to expand and modernize significantly the acquisition and application of French accelerometer data (both strong and weak motion) in order to improve earthquake related research and public safety from earthquakes. This network is the result of co-operative efforts including academic institutions (INSU-CNRS, Universities of Grenoble, Nice, Strasbourg, Toulouse, IPG Paris) and several state agencies (BRGM, CEA, IRSN, LCPC). Since 1995, around 120 stations have been installed in some seismic areas of France. This network also includes specific research actions (site effects, building monitoring, deep borehole). Other French accelerometer stations devoted to strong motion recording are also associated to the network. All data are archived and freely distributed in a database center, data being available in SAC, ASCII and SEED format. (authors)

  5. SSA Unified Measurement System (SUMS) Appeals Operational Data Store

    Data.gov (United States)

    Social Security Administration — Current agency tracking of all appeals information from reconsiderations through appeals council. Includes all appeals from Title 2, Title 16, and some Medicare Part...

  6. HUD Hearings and Appeals Office Decisions

    Data.gov (United States)

    Department of Housing and Urban Development — These all of the Administrative Sanction decisions issued by the Office of Appeals and its predecessor, the HUD Board of Contract Appeals. This Office has included...

  7. 43 CFR 4.1272 - Interlocutory appeals.

    Science.gov (United States)

    2010-10-01

    ... PROCEDURES Special Rules Applicable to Surface Coal Mining Hearings and Appeals Appeals to the Board from... modification of the administrative law judge's interlocutory ruling or order, the jurisdiction of the Board...

  8. 10 CFR 765.22 - Appeals procedures.

    Science.gov (United States)

    2010-01-01

    ... invoke the appeals process specified in paragraph (b) of this section. (b) A licensee shall file an... appeal must be filed within 45 days from the date the licensee received notice, actual or constructive (i...

  9. 7 CFR 205.681 - Appeals.

    Science.gov (United States)

    2010-01-01

    ... Secretary. (1) If the Administrator or State organic program sustains a certification applicant's or..., Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Administrative Adverse Action Appeal Process § 205.681 Appeals. (a...

  10. 11 CFR 7.32 - Appeal.

    Science.gov (United States)

    2010-01-01

    ... Administrative Enforcement Proceedings § 7.32 Appeal. (a) Right of appeal. Within ten days after receipt by... shall be based solely on the hearing record or those portions thereof cited by the parties to limit the...

  11. 14 CFR 1212.400 - Appeals.

    Science.gov (United States)

    2010-01-01

    ..., Washington, DC 20546; (2) Be identified clearly on the envelope and in the letter as an “Appeal under the... the date of the requester's receipt of the initial determination. Appeals involving failure to grant...

  12. Changes in the prevalence of alcohol use in rap song lyrics, 1979-97.

    Science.gov (United States)

    Herd, Denise

    2005-09-01

    This paper explores the role of changing images of drinking and alcoholic beverage use in rap music from its beginnings in the United States in the late 1970s to the late 1990s. A sample of 341 rap music song lyrics released from 1979 to 1997 were selected using Billboard and Gavin rating charts. Song lyrics were coded for music genres, alcohol beverage types and brand names, drinking behaviors, drinking contexts, intoxication, attitudes towards alcohol and consequences of drinking. From 1979 to 1997, songs with references to alcohol increased fivefold (from 8 to 44%); those exhibiting positive attitudes rose from 43% to 73%; and brand name mentions increased from 46% to 71%. There were also significant increases in songs mentioning champagne and liquor (mainly expensive brand names) when comparing songs released after 1994 with those from previous years. In addition, there were significant increases in references to alcohol to signify glamour and wealth, and using alcohol with drugs and for recreational purposes. The findings also showed that alcohol use in rap music was much more likely to result in positive than negative consequences. Many of these findings are consistent with the idea that rap music has been profoundly affected by commercial forces and the marketing of alcoholic beverages. In addition, it is possible that the increase in references to alcoholic beverages in rap music, particularly spirits, is a reflection of a broader advertising culture which increasingly associates African Americans with alcohol use.

  13. Analysis of the finescale timing of repeated signals: does shell rapping in hermit crabs signal stamina?

    Science.gov (United States)

    Briffa; Elwood

    2000-01-01

    Hermit crabs, Pagurus bernhardus, sometimes exchange shells after a period of shell rapping, when the initiating or attacking crab brings its shell rapidly and repeatedly into contact with the shell of the noninitiator or defender in a series of bouts. Bouts are separated by pauses, and raps within bouts are separated by very short periods called 'gaps'. Since within-contest variation is missed when signals are studied by averaging performance rates over entire contests, we analysed the fine within-bout structure of this repeated, aggressive signal. We found that the pattern is consistent with high levels of fatigue in initiators. The duration of the gaps between individual raps increased both within bouts and from bout to bout, and we conclude that this activity is costly to perform. Furthermore, long pauses between bouts is correlated with increased vigour of rapping in the subsequent bout, which suggests that the pause allows for recovery from fatigue induced by rapping. These between-bout pauses may be assessed by noninitiators and provide a signal of stamina. Copyright 2000 The Association for the Study of Animal Behaviour.

  14. Rap1 integrates tissue polarity, lumen formation, and tumorigenicpotential in human breast epithelial cells

    Energy Technology Data Exchange (ETDEWEB)

    Itoh, Masahiko; Nelson, Celeste M.; Myers, Connie A.; Bissell,Mina J.

    2006-09-29

    Maintenance of apico-basal polarity in normal breast epithelial acini requires a balance between cell proliferation, cell death, and proper cell-cell and cell-extracellular matrix signaling. Aberrations in any of these processes can disrupt tissue architecture and initiate tumor formation. Here we show that the small GTPase Rap1 is a crucial element in organizing acinar structure and inducing lumen formation. Rap1 activity in malignant HMT-3522 T4-2 cells is appreciably higher than in S1 cells, their non-malignant counterparts. Expression of dominant-negative Rap1 resulted in phenotypic reversion of T4-2 cells, led to formation of acinar structures with correct apico-basal polarity, and dramatically reduced tumor incidence despite the persistence of genomic abnormalities. The resulting acini contained prominent central lumina not observed when other reverting agents were used. Conversely, expression of dominant-active Rap1 in T4-2 cells inhibited phenotypic reversion and led to increased invasiveness and tumorigenicity. Thus, Rap1 acts as a central regulator of breast architecture, with normal levels of activation instructing apical polarity during acinar morphogenesis, and increased activation inducing tumor formation and progression to malignancy.

  15. Changing images of violence in Rap music lyrics: 1979-1997.

    Science.gov (United States)

    Herd, Denise

    2009-12-01

    Rap music has been at the center of concern about the potential harmful effects of violent media on youth social behavior. This article explores the role of changing images of violence in rap music lyrics from the 1970s to the 1990s. The results indicate that there has been a dramatic and sustained increase in the level of violence in rap music. The percentage of songs mentioning violence increased from 27 per cent during 1979-1984 to 60 per cent during 1994-1997. In addition, portrayals of violence in later songs are viewed in a more positive light as shown by their increased association with glamor, wealth, masculinity, and personal prowess. Additional analyses revealed that genre, specifically gangster rap, is the most powerful predictor of the increased number of violent references in songs. The discussion suggests that violence in rap music has increased in response to the complex interplay of changing social conditions such as the elevated levels of youth violence in the 1980s and changing commercial practices within the music industry.

  16. Metric Ambiguity and Flow in Rap Music: A Corpus-Assisted Study of Outkast's "Mainstream" (1996

    Directory of Open Access Journals (Sweden)

    Mitchell Ohriner

    2017-01-01

    Full Text Available Recent years have seen the rise of musical corpus studies, primarily detailing harmonic tendencies of tonal music. This article extends this scholarship by addressing a new genre (rap music and a new parameter of focus (rhythm. More specifically, I use corpus methods to investigate the relation between metric ambivalence in the instrumental parts of a rap track (i.e., the beat and an emcee's rap delivery (i.e., the flow. Unlike virtually every other rap track, the instrumental tracks of Outkast's "Mainstream" (1996 simultaneously afford hearing both a four-beat and a three-beat metric cycle. Because three-beat durations between rhymes, phrase endings, and reiterated rhythmic patterns are rare in rap music, an abundance of them within a verse of "Mainstream" suggests that an emcee highlights the three-beat cycle, especially if that emcee is not prone to such durations more generally. Through the construction of three corpora, one representative of the genre as a whole, and two that are artist specific, I show how the emcee T-Mo Goodie's expressive practice highlights the rare three-beat affordances of the track.

  17. Neuronal Rap1 Regulates Energy Balance, Glucose Homeostasis, and Leptin Actions.

    Science.gov (United States)

    Kaneko, Kentaro; Xu, Pingwen; Cordonier, Elizabeth L; Chen, Siyu S; Ng, Amy; Xu, Yong; Morozov, Alexei; Fukuda, Makoto

    2016-09-13

    The CNS contributes to obesity and metabolic disease; however, the underlying neurobiological pathways remain to be fully established. Here, we show that the small GTPase Rap1 is expressed in multiple hypothalamic nuclei that control whole-body metabolism and is activated in high-fat diet (HFD)-induced obesity. Genetic ablation of CNS Rap1 protects mice from dietary obesity, glucose imbalance, and insulin resistance in the periphery and from HFD-induced neuropathological changes in the hypothalamus, including diminished cellular leptin sensitivity and increased endoplasmic reticulum (ER) stress and inflammation. Furthermore, pharmacological inhibition of CNS Rap1 signaling normalizes hypothalamic ER stress and inflammation, improves cellular leptin sensitivity, and reduces body weight in mice with dietary obesity. We also demonstrate that Rap1 mediates leptin resistance via interplay with ER stress. Thus, neuronal Rap1 critically regulates leptin sensitivity and mediates HFD-induced obesity and hypothalamic pathology and may represent a potential therapeutic target for obesity treatment. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  18. Neuronal Rap1 Regulates Energy Balance, Glucose Homeostasis, and Leptin Actions

    Directory of Open Access Journals (Sweden)

    Kentaro Kaneko

    2016-09-01

    Full Text Available The CNS contributes to obesity and metabolic disease; however, the underlying neurobiological pathways remain to be fully established. Here, we show that the small GTPase Rap1 is expressed in multiple hypothalamic nuclei that control whole-body metabolism and is activated in high-fat diet (HFD-induced obesity. Genetic ablation of CNS Rap1 protects mice from dietary obesity, glucose imbalance, and insulin resistance in the periphery and from HFD-induced neuropathological changes in the hypothalamus, including diminished cellular leptin sensitivity and increased endoplasmic reticulum (ER stress and inflammation. Furthermore, pharmacological inhibition of CNS Rap1 signaling normalizes hypothalamic ER stress and inflammation, improves cellular leptin sensitivity, and reduces body weight in mice with dietary obesity. We also demonstrate that Rap1 mediates leptin resistance via interplay with ER stress. Thus, neuronal Rap1 critically regulates leptin sensitivity and mediates HFD-induced obesity and hypothalamic pathology and may represent a potential therapeutic target for obesity treatment.

  19. Characterization of local goat breeds using RAP-DNA markers

    Science.gov (United States)

    Al-Barzinji, Yousif M. S.; Hamad, Aram O.

    2017-09-01

    The present study was conducted on different colors of local goat breeds. A number of 216 does were sampled from the seven groups. Genomic DNA was extracted from the blood samples. From the twenty used RAPD primers 12 of them were amplified, and presence of bands. The total fragment number of 12 primers over all the goat breed samples was 485 fragments. Out of the 485 fragments, 90 of them were Polymorphic fragments numbers (PFN). From all bands obtained, 20 of them possessed unique bands. The highest unique band was found in locus RAP 6 which has 4 unique bands, three of them in the Maraz Brown and one in the local Koor. Nei's gene diversity and Shanon's information index in this study were averaged 0.38 and 0.60, respectively. The genetic distance among several goat breeds ranged from 9.11 to 43.33%. The highest genetic distance 43.33% recorded between Maraz goat and other goat breeds and between local Koor and other goat (except Maraz goats) breeds (37.79%). However, the lowest genetic distance recorded between local white and Pnok. The distance between (local Black and Pnok) and (local Black and local white) was 22.75%. In conclusions, the high distance among these goat breeds, polymorphism and high numbers of unique bands found in present study indicates that these goat breeds have the required amount of genetic variation to made genetic improvement. This study helps us to clarify the image of the genetic diversity of the local goat breeds and the breeders can used it for mating system when need to make the crossing among these goat breeds.

  20. 33 CFR 154.1075 - Appeal process.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Appeal process. 154.1075 Section 154.1075 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED....1075 Appeal process. (a) Any owner or operator of a facility who desires to appeal the classification...

  1. 32 CFR 203.19 - Appeals process.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Appeals process. 203.19 Section 203.19 National....19 Appeals process. DoD Components will establish an appeals process to settle potential disputes... process. The Department of Defense recognizes that the RAB/TRC may disagree with the findings of the...

  2. 13 CFR 134.402 - Appeal petition.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Appeal petition. 134.402 Section 134.402 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING... § 134.402 Appeal petition. In addition to the requirements of § 134.203, an appeal petition must state...

  3. 48 CFR 907.307 - Appeals.

    Science.gov (United States)

    2010-10-01

    ... ACQUISITION PLANNING Contractor Versus Government Performance 907.307 Appeals. An appeal of a decision to convert to contract or to continue in-house performance may be made by an affected party. Appeals shall be made in writing, be based only on specific alleged material deviation (or deviations),from OMB Circular...

  4. 49 CFR 98.10 - Appeal.

    Science.gov (United States)

    2010-10-01

    ... Administration of Enforcement Proceedings § 98.10 Appeal. (a) Within 30 working days after receipt of a decision issued under § 98.8 or § 98.9 of this part, either the Departmental counsel or the former employee may appeal the decision to the Secretary. (b) In making a decision on an appeal, the Secretary shall consider...

  5. 28 CFR 16.9 - Appeals.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Appeals. 16.9 Section 16.9 Judicial Administration DEPARTMENT OF JUSTICE PRODUCTION OR DISCLOSURE OF MATERIAL OR INFORMATION Procedures for Disclosure of Records Under the Freedom of Information Act § 16.9 Appeals. (a) Appeals of adverse...

  6. 7 CFR 29.430 - Appeals.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Appeals. 29.430 Section 29.430 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... INSPECTION Regulations Miscellaneous § 29.430 Appeals. Appeals of test results for imported tobacco must be...

  7. 78 FR 43843 - Clarification of Appeal Procedures

    Science.gov (United States)

    2013-07-22

    ... definition of an Order, the timing of appeals of orders to perform restructured accounting, and the finality... appeal an order to perform a restructured accounting involving only Federal oil and gas leases under the...). Generally, under the proposed rule, you would appeal an Order to Perform a Restructured Accounting to the...

  8. 28 CFR 79.73 - Appeals procedures.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Appeals procedures. 79.73 Section 79.73 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) CLAIMS UNDER THE RADIATION EXPOSURE COMPENSATION ACT Procedures § 79.73 Appeals procedures. (a) An appeal must be in writing and must be received by...

  9. Administrative Appeals and ADR in Danish Administrative Law

    DEFF Research Database (Denmark)

    Conradsen, Inger Marie; Gøtze, Michael

    2014-01-01

    Administrative Appeals, review, administrative tribunals, ombudsman, alternative dispute resolution......Administrative Appeals, review, administrative tribunals, ombudsman, alternative dispute resolution...

  10. Appeals in Web Advertising : Exploring the influence of ethical and financial appeals on consumer attitudes

    OpenAIRE

    Klingström, Jonas

    2014-01-01

    Advertising has been a common element in the web experience for years. Advertisers can use many strategies to reach their intended consumer, and can appeal to for example rationality, emotion or ethics. Using theories on the composition of ads, their context and the web user, this paper presents a study testing two types of advertising appeals – an ethical appeal and a financial appeal. The experiment tested for the effect of these appeals on outcome measures of attitude, trust and credibilit...

  11. Changes in the prevalence of alcohol in rap music lyrics 1979-2009.

    Science.gov (United States)

    Herd, Denise

    2014-02-01

    This study examines the prevalence and context of alcohol references in rap music lyrics from 1979 through 2009. Four hundred nine top-ranked rap music songs released were sampled from Billboard magazine rating charts. Songs were analyzed using systematic content analysis and were coded for alcohol beverage types and brand names, drinking behaviors, drinking contexts, attitudes towards alcohol, and consequences of drinking. Trends were analyzed using regression analyses. The results of the study reveal significant increases in the presence of alcohol in rap songs; a decline in negative attitudes towards alcohol; decreases in consequences attributed to alcohol; increases in the association of alcohol with glamour and wealth, drugs, and nightclubs; and increases in references to liquor and champagne.

  12. Product (P1) from project 0-6738 : performance studies and future directions for mixes containing RAP and RAS.

    Science.gov (United States)

    2013-01-01

    In recent years both reclaimed asphalt pavement (RAP) and recycled asphalt shingles (RAS) have been widely used in asphalt mixes by the asphalt paving industry in Texas. The use of RAP and RAS can save tax payers money, and it is also good for the...

  13. How CAGE, RAPS4QF and AUDIT can help practitioners for patients admitted with acute alcohol intoxication in emergency departments?

    Directory of Open Access Journals (Sweden)

    Georges eBrousse

    2014-06-01

    Full Text Available Aims: To help clinicians to identify the severity of Alcohol Use Disorders (AUD from optimal thresholds found for recommended scales. Especially, taking account of the high prevalence of alcohol dependence among patients admitted to the Emergency Department (ED for acute alcohol intoxication (AAI, we propose to define thresholds of severity of dependence based on the AUDIT score.Methods: All patients admitted to the ED with AAI (blood alcohol level >0.8g/L, in a two-month period, were assessed using the CAGE, RAPS-QF and AUDIT, with the alcohol dependence/abuse section of the Mini International Neuropsychiatric Interview (MINI used as the gold standard. To explore the relation between the AUDIT and the MINI the sum of the positive items on the MINI (dependence as a quantitative variable and as an ordinal parameter were analyzed. From the threshold score (TS found for each scale we proposed intervals of severity of Alcohol Use Disorders (AUDs. Results: The mean age of the sample (122 males, 42 females was 46 years. Approximately 12 % of the patients were identified with alcohol abuse and 78 % with dependence (DSM-IV. Cut points were determined for the AUDIT in order to distinguish mild and moderate dependence from severe dependence. A strategy of intervention based on levels of severity of AUD was proposed. Conclusion: Different thresholds proposed for the CAGE, RAPS4-QF and AUDIT could be used to guide the choice of intervention for a patient: brief intervention, brief negotiation interviewing or longer more intensive motivational intervention.

  14. The Art of Appeal in Electronic Commerce

    DEFF Research Database (Denmark)

    Liu, Albert Fei; Xiao, Bo Sophia; Lim, Eric T. K.

    2017-01-01

    Purpose: The purpose of this paper is to advance product appeal and website appeal as focal psychological mechanisms that can be invoked by business-to-consumer e-commerce sites to mitigate problems of information asymmetry via signaling to bolster consumers’ purchase intention under the influence...... product and website appeal. Trust is revealed to exert a moderating influence on the impact of product and website appeal on purchase intention. Practical implications: Practitioners should prioritize their resource allocation to enhance qualities most pertinent to product and website appeal. E...... of trust. Design/methodology/approach: Survey approach was employed to validate the research model. Findings: Website appeal partially mediates the positive effect of product appeal on consumers’ purchase intention. Trust in e-commerce sites not only increases purchase intention directly, but it also...

  15. Molecular characterization and chromosomal assignment of equine cartilage derived retinoic acid sensitive protein (CD-RAP)/melanoma inhibitory activity (MIA)

    DEFF Research Database (Denmark)

    Berg, Lise Charlotte; Mata, Xavier; Thomsen, Preben Dybdahl

    2008-01-01

    Cartilage-derived retinoic acid sensitive protein (CD-RAP) also known as melanoma inhibitory activity (MIA) has already been established as a marker for chondrocyte differentiation and a number of cancerous condition sin humans. Studies have also shown that CD-RAP/MIA is a potential marker of joint......RNA in articular cartilage and chondrocytes from horses with no signs of joint disease. The expression decreased as the cells dedifferentiated in monolayer culture. We also identified an equine CD-RAP/MIA splioce variant similar to that reported in humans. The CD_RAP/MIA protein was detected in equine synovial...... fluid, serum and culture medium from chondrocyte cultures. In conclusion, CD-RAP/MIA is expressed in equine cartilage and chondrocytes, and the protein can be detected in equine serum, synovial fluid and in culture medium from chondrocyte cultures. The equine gene and resulting protein share great...

  16. Ultrastructural and biochemical localization of N-RAP at the interface between myofibrils and intercalated disks in the mouse heart.

    Science.gov (United States)

    Zhang, J Q; Elzey, B; Williams, G; Lu, S; Law, D J; Horowits, R

    2001-12-11

    N-RAP is a recently discovered muscle-specific protein found at cardiac intercalated disks. Double immunogold labeling of mouse cardiac muscle reveals that vinculin is located immediately adjacent to the fascia adherens region of the intercalated disk membrane, while N-RAP extends approximately 100 nm further toward the interior of the cell. We partially purified cardiac intercalated disks using low- and high-salt extractions followed by density gradient centrifugation. Immunoblots show that this preparation is highly enriched in desmin and junctional proteins, including N-RAP, talin, vinculin, beta1-integrin, N-cadherin, and connexin 43. Electron microscopy and immunolabeling demonstrate that N-RAP and vinculin are associated with the large fragments of intercalated disks that are present in this preparation, which also contains numerous membrane vesicles. Detergent treatment of the partially purified intercalated disks removed the membrane vesicles and extracted vinculin and beta1-integrin. Further separation on a sucrose gradient removed residual actin and myosin and yielded a fraction morphologically similar to fasciae adherentes that was highly enriched in N-RAP, N-cadherin, connexin 43, talin, desmin, and alpha-actinin. The finding that N-RAP copurifies with detergent-extracted intercalated disk fragments even though beta-integrin and vinculin have been completely removed suggests that N-RAP association with the adherens junction region is mediated by the cadherin system. Consistent with this hypothesis, we found that recombinant N-RAP fragments bind alpha-actinin in a gel overlay assay. In addition, immunofluorescence shows that N-RAP remains bound at the ends of isolated, detergent-treated cardiac myofibrils. These results demonstrate that N-RAP remains tightly bound to myofibrils and fasciae adherentes during biochemical purification and may be a key constituent in the mechanical link between these two structures.

  17. Anti-inflammatory and analgesic activity of r.a.p . ( Radix Angelicae ...

    African Journals Online (AJOL)

    The objective of this paper was to study the anti-inflammatory and analgesic effects of Radix Angelicae Pubescentis (R.A.P) ethanol extracts. Three classic anti-inflammatory models and two analgesic models were used in this research. In anti-inflammatory tests, all the extracts have a certain inhibition on the acute ...

  18. An Interview with Cathy Fowler about Sharing a Love of Reading through Book Raps.

    Science.gov (United States)

    Strangman, Nicole

    2002-01-01

    Includes an interview with Cathy Fowler, a Year 7 teacher at Kawungan State School in Queensland, Australia. Explains that Cathy is a participant and coordinator of the extremely popular Harry Potter Book Rap, a guided Internet book discussion among students all over the world. Discusses how this activity fueled her students' love for reading. (PM)

  19. Mortality in American Hip-Hop and Rap Recording Artists, 1987-2014.

    Science.gov (United States)

    Lawson, Carl J

    2015-12-01

    The deaths of American hip-hop and rap recording artists often receive considerable media attention. However, these artists' deaths have not been examined as a distinct group like the deaths of rock, classical, jazz, and pop music artists. This is a seminal epidemiological analysis on the deaths of an understudied group, American hip-hop and rap music recording artists. Media reports were analyzed of the deaths of American hip-hop and rap music recording artists that occurred from January 1, 1987 to December 31, 2014. The decedents' age, sex, race, cause of death, stage names, and city and state of death were recorded for analysis. The most commonly reported cause of death was homicide. The 280 deaths were categorized as homicide (55%), unintentional injury (13%), cardiovascular (7%), undetermined/undisclosed (7%), cancer (6%), other (5%), suicide (4%), and infectious disease (3%). The mean reported age at death was 30 yrs (range 15-75) and the median was 29 yrs; 97% were male and 92% were black. All but one of the homicides were committed with firearms. Homicide was the most commonly reported cause of death. Public health focus and guidance for hip-hop and rap recording artists should mirror that for African-American men and adolescent males ages 15-54 yrs, for whom the leading causes of death are homicide, unintentional injury, and heart disease. Given the preponderance of homicide deaths in this analysis, premature mortality reduction efforts should focus on violence prevention and conflict mitigation.

  20. Rap as the language of conflict in hip-hop subculture

    Directory of Open Access Journals (Sweden)

    Т М Кожелупенко

    2008-12-01

    Full Text Available This article is devoted to such notions of sociolinguistics as subculture and the language of conflict. These aspects are studied by the example of the rapidly developing hip-hop subculture and rap-texts as its main component.

  1. RAP-IA code for calculus thermodinamic of the fast reactors

    International Nuclear Information System (INIS)

    Popescu, C.; Turcu, I.; Boeriu, S.; Biro, L.

    1975-01-01

    The RAP-IA code is developed in order to perform a complete calculation for a thermal channel of a Na-cooled fast reactor. Calculation may be effected for both stationary state and dynamic regime following modification of some in-put data: total thermal power, multiplication coefficient, flow-rate and in-put temperature of the thermal agent, pressure level

  2. Rap and Resistance: A Social Movement of the Wu-Tang Clan.

    Science.gov (United States)

    Chasteen, Amy L.; Shriver, Thomas

    1998-01-01

    Examines specific collective identity and political expression of the rap group the Wu-Tang Clan. Reveals a multi-layered political strategy that has been conscientiously designed and implemented to instigate a social movement. Prioritizes the voices of marginalized Black peoples and provides raw narratives about oppression. (MMU)

  3. Illuminating Chaucer through Poetry, Manuscript Illuminations, and a Critical Rap Album

    Science.gov (United States)

    Lynch, Tom Liam

    2007-01-01

    Drawing connections between Chaucer, Eminem, and social issues, New York City high school teacher Tom Liam Lynch helped students become familiar with "The Canterbury Tales." Students wrote poems of rhymed couplets about today's social and political issues, created illuminated manuscripts, and recorded a rap CD. A book and album were…

  4. Rapping in Catalan in Class and the Empowerment of the Learner

    Science.gov (United States)

    Aliagas, Cristina; Fernández, Júlia-Alba; Llonch, Pau

    2016-01-01

    Despite the well-known educational possibilities afforded by "Rhythm And Poetry" (RAP) for the development of musical, lyrical and critical skills [Morrell, E., & Duncan-Andrade, J. M. R. (2002). Promoting Academic Literacy with Urban Youth through Engaging Hip-hop Culture. "The English Journal," 91(6), 88-92. Retrieved…

  5. Neuronal Rap1 regulates energy balance, glucose homeostasis, and leptin actions

    Science.gov (United States)

    The Central Nervous System (CNS) contributes to obesity and metabolic disease; however, the underlying neurobiological pathways remain to be fully established. Here, we show that the small GTPase Rap1 is expressed in multiple hypothalamic nuclei that control whole-body metabolism and is activated in...

  6. Rap van tong, scherp van pen. Literaire discussiecultuur in Nederlandse praatjespamfletten (circa 1600-1750)

    NARCIS (Netherlands)

    Dingemanse, C.W.

    2008-01-01

    In the early modern period pamphlets constituted the most important medium to influence public opinion in the Netherlands. The thesis Rap van tong, scherp van pen (Glib tongues, sharp pens) focuses on the literary and rhetorical aspects of a remarkable type of pamphlet called praatje (small-talk),

  7. From Violent Rap to Lovely Blues: The Transformation of Aggressive Behavior through Vocal Music Therapy.

    NARCIS (Netherlands)

    Meadows, Tony; Uhlig, S.

    2011-01-01

    The voice as a primary therapeutic instrument will be addressed in this chapter. Through vocal expression, chaos can be transformed into order – crying into singing, aggressive shouting into the structure of a rap song. This transformation of emotions demonstrates the ability to change behavior and

  8. The right to appeal a judgment of the Extraordinary Chambers in the courts of Cambodia

    NARCIS (Netherlands)

    O'Neill, L.; Sluiter, G.

    2009-01-01

    In early 2007, we submitted a report to the Extraordinary Chambers in the Courts of Cambodia commenting on several aspects of its then-draft Internal Rules, including whether the ECCC’s envisaged appeal system adhered to international standards. The Internal Rules were adopted in June 2007, and then

  9. As mensagens sobre drogas no rap: como sobreviver na periferia Messages about drugs from rap: how to survive in the periferia

    Directory of Open Access Journals (Sweden)

    Vinícius Gonçalves Bento da Silva

    2004-12-01

    Full Text Available O objetivo é analisar as mensagens sobre drogas nas letras de rap de grupos com representatividade e influência entre jovens da periferia de São Paulo. O rap é um gênero musical que faz parte de um movimento cultural - o hip hop -, que difunde uma visão social de mundo, principalmente nas periferias das grandes cidades. Por meio da Análise de Discurso estudaram-se 11 letras de 9 grupos. O tema marcante é a vida na periferia retratada pelo tráfico e consumo de drogas, pela violência e pela discriminação. O uso de drogas é compreendido por alguns grupos como conseqüência do modo de produção, e por outros, pelas características individuais, pela influência da família e dos amigos. As propostas para o enfrentamento e para a superação dos problemas estão voltadas à responsabilização do sujeito que, através de um esforço pessoal, não se envolveria com o tráfico e consumo de drogas consideradas perigosas e destrutivas como o crack e a cocaína. O fortalecimento de laços familiares e de amizade e a educação são também vistos como saídas para os problemas advindos do envolvimento com as drogas. As propostas invocam um discurso que, além de denunciar a situação dos jovens da periferia, propõe mecanismos de proteção para criar uma alternativa de "vida possível" - de convivência com a violência, com o tráfico e consumo de drogas.The objective was to analyze the messages about drugs of the rap lyrics from representative and influential groups among the youth living in the periferias of São Paulo. It understands that rap is a kind of music that is part of cultural movement - the hip hop - that disseminates a particular set of ideas, mainly in the periferias of the big cities. Through Discourse Analysis 11 lyrics of 9 rap groups were taken as a sample. The outstanding theme of the lyrics is the situation of the segregated areas of the city, including the presence of drug trafficking and consumption, as well as

  10. O rap dos Racionais MC\\'s em sala de aula como via de emancipação de jovens na periferia de São Paulo: análises de oficinas musicais com ênfase no rap

    OpenAIRE

    Raquel Mendonça Martins

    2015-01-01

    A presente dissertação de mestrado teve o propósito de pesquisar em que medida a estética multifacetada do rap pode ser utilizada nos processos de formação de adolescentes pobres e moradores das periferias, em sua maioria, afrodescendentes. Ao identificar no rap um potencial de ruptura e de resistência frente às formas atuais de discriminação racial - tanto em seus aspectos musicais, quanto narrativos - foram realizadas oficinas de música com ênfase no rap, envolvendo jovens entre treze e qui...

  11. Impact of Advertising Appeals on Purchase Intention

    OpenAIRE

    Predrag Jovanović; Tamara Vlastelica; Slavica Cicvarić Kostić

    2016-01-01

    Companies use various appeals in their advertising practice to impact consumers’ attitudes and purchase intention by an advertisement. Advertising appeals can be divided into rational or emotional, depending on whether companies want to influence the rational or the emotional motives of the consumer to purchase of the advertised product. Since there is no general pattern for the use of appeals and the success of an advertising message, this study aims to explore the impact of the emotional an...

  12. Activation of the Small GTPase Rap1 Inhibits Choroidal Neovascularization by Regulating Cell Junctions and ROS Generation in Rats.

    Science.gov (United States)

    Li, Jiajia; Zhang, Rong; Wang, Caixia; Wang, Xin; Xu, Man; Ma, Jingxue; Shang, Qingli

    2018-03-30

    Choroidal neovascularization (CNV) is a common vision-threatening complication associated with many  fundus diseases. The retinal pigment epithelial (RPE) cell junction barrier has critical functions in preventing CNV, and oxidative stress can cause compromise of barrier integrity and induce angiogenesis. Rap1, a small guanosine triphosphatase (GTPase), is involved in regulating endothelial and epithelial cell junctions. In this work, we explored the function and mechanism of Rap1 in CNV in vivo. A laser-induced rat CNV model was developed. Rap1 was activated through intravitreal injection of the Rap1 activator 8CPT-2'-O-Me-cAMP (8CPT). At 14 days after laser treatment, CNV size in RPE/choroid flat mounts was measured by fluorescein isothiocyanate-dextran staining. Expression of vascular endothelial growth factor (VEGF) and cell junction proteins in RPE/choroid tissues were analyzed by western blots and quantitative real-time PCR assays. Reactive oxygen species (ROS) in RPE cells were detectedbydichloro-dihydro-fluorescein diacetate assays. The antioxidant apocynin was intraperitoneally injected into rats. Activating Rap1 by 8CPT significantly reduced CNV size and VEGF expression in the rat CNV model. Rap1 activation enhanced protein and mRNA levels of ZO-1 and occludin, two tight junction proteins in the RPE barrier. In addition, reducing ROS generation by injection of apocynin, a NADPH oxidase inhibitor, inhibited CNV formation. Rap1 activation reduced ROS generation and expression of NADPH oxidase 4. Rap1 activation inhibits CNV through regulating barrier integrity and ROS generation of RPE in vivo, and selectively activating Rap1 may be a way to reduce vision loss from CNV.

  13. Sixty years of fear appeal research: current state of the evidence.

    Science.gov (United States)

    Ruiter, Robert A C; Kessels, Loes T E; Peters, Gjalt-Jorn Y; Kok, Gerjo

    2014-04-01

    Fear arousal is widely used in persuasive campaigns and behavioral change interventions. Yet, experimental evidence argues against the use of threatening health information. The authors reviewed the current state of empirical evidence on the effectiveness of fear appeals. Following a brief overview of the use of fear arousal in health education practice and the structure of effective fear appeals according to two main theoretical frameworks-protection motivation theory and the extended parallel process model-the findings of six meta-analytic studies in the effectiveness of fear appeals are summarized. It is concluded that coping information aimed at increasing perceptions of response effectiveness and especially self-efficacy is more important in promoting protective action than presenting threatening health information aimed at increasing risk perceptions and fear arousal. Alternative behavior change methods than fear appeals should be considered. © 2014 The Authors. International Journal of Psychology published by John Wiley © Sons Ltd on behalf of International Union of Psychological Science.

  14. Office of Medicare Hearings and Appeals (OMHA) - Receipts by Appeal Category

    Data.gov (United States)

    U.S. Department of Health & Human Services — This data set provides information about the appeals and claims received by the Office of Medicare and Hearings by appeal category for Fiscal Year 2006 - 2012.

  15. Impact of Advertising Appeals on Purchase Intention

    Directory of Open Access Journals (Sweden)

    Predrag Jovanović

    2016-04-01

    Full Text Available Companies use various appeals in their advertising practice to impact consumers’ attitudes and purchase intention by an advertisement. Advertising appeals can be divided into rational or emotional, depending on whether companies want to influence the rational or the emotional motives of the consumer to purchase of the advertised product. Since there is no general pattern for the use of appeals and the success of an advertising message, this study aims to explore the impact of the emotional and rational advertising appeals on the purchase intention. The results of the empirical research, conducted using the focus groups method, are shown in this paper and the focus group participants were members of the student population.The research results indicate that different advertising appeals may have a different impact on the consumer’s purchase intention; in case of women, the emotional appeal has a stronger impact while for men it is the rational appeal, while “fear appeal” proved to be effective to a certain point, after which it causes selective perception and rejection. This implies that depending on the product, its purpose and target group, advertisers can choose the type of appeal, combination of the appeals and their creative presentation, based on the empirical confirmation of the efficiency the approach.

  16. Interagency Security Classification Appeals Panel (ISCAP) Decisions

    Data.gov (United States)

    National Archives and Records Administration — This online collection includes documents decided upon by the Interagency Security Classification Appeals Panel (ISCAP) starting in Fiscal Year 2012. The documents...

  17. Specificity versus redundancy in the RAP2.4 transcription factor family of Arabidopsis thaliana: transcriptional regulation of genes for chloroplast peroxidases.

    Science.gov (United States)

    Rudnik, Radoslaw; Bulcha, Jote Tafese; Reifschneider, Elena; Ellersiek, Ulrike; Baier, Margarete

    2017-08-23

    The Arabidopsis ERFIb / RAP2.4 transcription factor family consists of eight members with highly conserved DNA binding domains. Selected members have been characterized individually, but a systematic comparison is pending. The redox-sensitive transcription factor RAP2.4a mediates chloroplast-to-nucleus redox signaling and controls induction of the three most prominent chloroplast peroxidases, namely 2-Cys peroxiredoxin A (2CPA) and thylakoid- and stromal ascorbate peroxidase (tAPx and sAPx). To test the specificity and redundancy of RAP2.4 transcription factors in the regulation of genes for chloroplast peroxidases, we compared the DNA-binding sites of the transcription factors in tertiary structure models, analyzed transcription factor and target gene regulation by qRT-PCR in RAP2.4, 2-Cys peroxiredoxin and ascorbate peroxidase T-DNA insertion lines and RAP2.4 overexpressing lines of Arabidopsis thaliana and performed promoter binding studies. All RAP2.4 proteins bound the tAPx promoter, but only the four RAP2.4 proteins with identical DNA contact sites, namely RAP2.4a, RAP2.4b, RAP2.4d and RAP2.4h, interacted stably with the redox-sensitive part of the 2CPA promoter. Gene expression analysis in RAP2.4 knockout lines revealed that RAP2.4a is the only one supporting 2CPA and chloroplast APx expression. Rap2.4h binds to the same promoter region as Rap2.4a and antagonizes 2CPA expression. Like the other six RAP2.4 proteins, Rap2.4 h promotes APx mRNA accumulation. Chloroplast ROS signals induced RAP2.4b and RAP2.4d expression, but these two transcription factor genes are (in contrast to RAP2.4a) insensitive to low 2CP availability, and their expression decreased in APx knockout lines. RAP2.4e and RAP2.4f gradually responded to chloroplast APx availability and activated specifically APx expression. These transcription factors bound, like RAP2.4c and RAP2.4g, the tAPx promoter, but hardly the 2CPA promoter. The RAP2.4 transcription factors form an environmentally and

  18. 77 FR 17055 - Intra-Agency Appeal Process: Guidelines for Appeals of Material Supervisory Determinations and...

    Science.gov (United States)

    2012-03-23

    ... the Equal Credit Opportunity Act or the Fair Housing Act. For the purposes of these guidelines... appealed. If oral presentation is sought, that request should be included in the appeal. Only matters... appeal if timeliness is at issue, rests with the institution. K. Oral Presentation The SARC may, in its...

  19. 43 CFR 4.478 - Appeals to the Board of Land Appeals; judicial review.

    Science.gov (United States)

    2010-10-01

    ... appeal to the Board from an order of an administrative law judge granting or denying a petition for a... judicial review under 5 U.S.C. 704 of a final BLM grazing decision if the administrative law judge denies a... decide the appeal promptly. (d) Unless the Board or a court orders otherwise, an appeal under paragraph...

  20. 8 CFR 244.11 - Renewal of application; appeal to the Board of Immigration Appeals.

    Science.gov (United States)

    2010-01-01

    ... of Immigration Appeals. 244.11 Section 244.11 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS TEMPORARY PROTECTED STATUS FOR NATIONALS OF DESIGNATED STATES § 244.11 Renewal of application; appeal to the Board of Immigration Appeals. If a charging document is served on the alien with a...

  1. 8 CFR 1244.11 - Renewal of application; appeal to the Board of Immigration Appeals.

    Science.gov (United States)

    2010-01-01

    ... of Immigration Appeals. 1244.11 Section 1244.11 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION REGULATIONS TEMPORARY PROTECTED STATUS FOR NATIONALS OF DESIGNATED STATES § 1244.11 Renewal of application; appeal to the Board of Immigration Appeals. If a charging...

  2. 77 FR 75641 - Public Housing Operating Subsidy-Appeals

    Science.gov (United States)

    2012-12-21

    ... substitute actual project cost data. To appeal the amount of subsidy on any one of the permitted bases of... conditions; and (e) appeal to substitute actual project cost data. To appeal the amount of subsidy on any one of the permitted bases of appeal, PHAs submit an appeal request to HUD. Number of Annual Hours per...

  3. 9 CFR 354.134 - Appeal inspections; how made.

    Science.gov (United States)

    2010-01-01

    ... the employee of the Department making the appeal inspection. The cost of any such appeal shall be... decision of an inspector relating to any inspection, file an appeal from such decision: Provided, That such appeal is filed within 48 hours from the time the decision was made. Any such appeal from a decision of...

  4. 9 CFR 381.35 - Appeal inspections; how made.

    Science.gov (United States)

    2010-01-01

    ... the employee of the Department making the appeal determination. The cost of any such appeal shall be... Employees; Appeals § 381.35 Appeal inspections; how made. Any person receiving inspection service may, if dissatisfied with any decision of an inspector relating to any inspection, file an appeal from such decision...

  5. 24 CFR 990.245 - Types of appeals.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Types of appeals. 990.245 Section... THE PUBLIC HOUSING OPERATING FUND PROGRAM Appeals § 990.245 Types of appeals. (a) Streamlined appeal. This appeal would demonstrate that the application of a specific Operating Fund formula component has a...

  6. 10 CFR 451.10 - Administrative appeals.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Administrative appeals. 451.10 Section 451.10 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION RENEWABLE ENERGY PRODUCTION INCENTIVES § 451.10 Administrative... application in whole or in part shall appeal, on or before 45 days from date of the notice issued by the DOE...

  7. 44 CFR 206.115 - Appeals.

    Science.gov (United States)

    2010-10-01

    ... want to purchase; or (10) Any other eligibility-related decision. (b) Appeals must be in writing and...; (7) Termination of direct housing assistance; (8) Denial of a request to purchase a FEMA-provided...) Applicants must appeal to the Regional Administrator or his/her designee for decisions made under this...

  8. 5 CFR 1630.14 - Appeals process.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Appeals process. 1630.14 Section 1630.14 Administrative Personnel FEDERAL RETIREMENT THRIFT INVESTMENT BOARD PRIVACY ACT REGULATIONS § 1630.14 Appeals process. (a) Within 20 work days of receiving the request for review, the Executive Director, after...

  9. 5 CFR 2504.16 - Appeals process.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Appeals process. 2504.16 Section 2504.16 Administrative Personnel OFFICE OF ADMINISTRATION, EXECUTIVE OFFICE OF THE PRESIDENT PRIVACY ACT REGULATIONS § 2504.16 Appeals process. (a) Within 20 work days of receiving the request for review, a review group...

  10. 44 CFR 295.41 - Administrative appeal.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Administrative appeal. 295.41 Section 295.41 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF... supplement the statement of reasons and provide any additional documentary evidence supporting the appeal...

  11. 7 CFR 1957.6 - Appeal reviews.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 14 2010-01-01 2009-01-01 true Appeal reviews. 1957.6 Section 1957.6 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... 1900, subpart B. This review is final and will conclude the appellant's administrative appeal process. ...

  12. 7 CFR 4284.4 - Appeals.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Appeals. 4284.4 Section 4284.4 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL... with USDA appeal regulations found at 7 CFR part 11 and subpart B of part 1900. If the Agency makes a...

  13. Measuring Appeal in Human Computer Interaction

    DEFF Research Database (Denmark)

    Neben, Tillmann; Xiao, Bo Sophia; Lim, Eric T.

    2015-01-01

    Appeal refers to the positive emotional response to an aesthetic, beautiful, or in another way desirable stimulus. It is a recurring topic in information systems (IS) research, and is important for understanding many phenomena of user behavior and decision-making. While past IS research on appeal...

  14. 9 CFR 204.7 - Appeals.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Appeals. 204.7 Section 204.7 Animals and Animal Products GRAIN INSPECTION, PACKERS AND STOCKYARDS ADMINISTRATION (PACKERS AND STOCKYARDS... person whose request under § 204.6 of this part is denied shall have the right to appeal such denial in...

  15. 12 CFR 925.5 - Appeals.

    Science.gov (United States)

    2010-01-01

    ... resolution. A copy of the Bank's decision resolution; and (ii) Basis for appeal. A statement of the basis for... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Appeals. 925.5 Section 925.5 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK MEMBERS AND HOUSING ASSOCIATES MEMBERS OF THE BANKS...

  16. 12 CFR 926.6 - Appeals.

    Science.gov (United States)

    2010-01-01

    ... appeal to the Finance Board that includes the Bank's decision resolution and a statement of the basis for... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Appeals. 926.6 Section 926.6 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK MEMBERS AND HOUSING ASSOCIATES FEDERAL HOME LOAN BANK...

  17. 44 CFR 62.20 - Claims appeals.

    Science.gov (United States)

    2010-10-01

    ... estimate. In order to file an appeal, the insured must comply with all requirements set out in the Standard... limits that are not provided by the SFIP. Filing an appeal does not waive any of the requirements for... documents including closings; evidence of insurability as a Residential Condominium Association; Franchise...

  18. 22 CFR 171.22 - Appeals.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Appeals. 171.22 Section 171.22 Foreign Relations DEPARTMENT OF STATE ACCESS TO INFORMATION AVAILABILITY OF INFORMATION AND RECORDS TO THE PUBLIC Executive Order 12958 Provisions § 171.22 Appeals. Any denial of a mandatory declassification review request...

  19. 12 CFR 404.11 - Administrative appeal.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Administrative appeal. 404.11 Section 404.11 Banks and Banking EXPORT-IMPORT BANK OF THE UNITED STATES INFORMATION DISCLOSURE Procedures for Disclosure of Records Under the Freedom of Information Act. § 404.11 Administrative appeal. (a) General...

  20. 20 CFR 435.80 - Appeal process.

    Science.gov (United States)

    2010-04-01

    ... Officer (GMO); and (2) Final appeal to the Commissioner of Social Security from an adverse decision... written decisions by the GMO may be appealed: (1) A disallowance or other determination denying payment of... decision and requirements of grantee response. The Grants Management Officer's (GMO) adverse post-award...

  1. 12 CFR 602.8 - Appeals.

    Science.gov (United States)

    2010-01-01

    ... in writing and addressed to the Director, Office of Management Services (OMS), Farm Credit... business days of receiving your appeal, the OMS Director will tell you, in writing, whether we have granted... until the OMS Director receives your appeal. (c) Unusual circumstances. In unusual circumstances, the...

  2. 76 FR 77327 - Disciplinary Appeals Board Panel

    Science.gov (United States)

    2011-12-12

    ... DEPARTMENT OF VETERANS AFFAIRS Disciplinary Appeals Board Panel AGENCY: Department of Veterans... Affairs Health Care Personnel Act of 1991 (Pub. L. 102-40), dated May 7, 1991, revised the disciplinary grievance and appeal procedures for employees appointed under 38 U.S.C. 7401(1). It also required the...

  3. 76 FR 8848 - Disciplinary Appeals Board Panel

    Science.gov (United States)

    2011-02-15

    ... DEPARTMENT OF VETERANS AFFAIRS Disciplinary Appeals Board Panel AGENCY: Department of Veterans... Affairs Health Care Personnel Act of 1991 (Pub. L. 102-40), dated May 7, 1991, revised the disciplinary grievance and appeal procedures for employees appointed under 38 U.S.C. 7401(1). It also required the...

  4. 17 CFR 8.19 - Appeal.

    Science.gov (United States)

    2010-04-01

    ... Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION EXCHANGE PROCEDURES FOR DISCIPLINARY, SUMMARY, AND MEMBERSHIP DENIAL ACTIONS Disciplinary Procedure § 8.19 Appeal. The rules of an exchange may permit a respondent to appeal promptly an adverse decision of a disciplinary committee in all or in...

  5. Effects of type of value appealed to and valence of appeal on children's dental health behavior.

    Science.gov (United States)

    Knapp, L G

    1991-12-01

    Examined the effects of the type of value appealed to and valence of appeal on children's intentions to engage in toothbrushing, their self-report of toothbrushing frequency, and their plaque level. 98 fifth-grade students served as the participants. Slide shows appealed to either health- or socially oriented values and also differed with respect to valence (positive vs. negative). A control group received a message that provided basic dental health information. Group comparisons revealed that children who received the negative social appeal showed a significant improvement in plaque level. Only the negative social appeal group differed significantly from the control group on the dependent measures.

  6. Crystal structure of the C-terminal domain of the RAP74 subunit of human transcription factor IIF

    Energy Technology Data Exchange (ETDEWEB)

    Kamada, Katsuhiko; De Angelis, Jacqueline; Roeder, Robert G.; Burley, Stephen K. (Rockefeller)

    2012-12-13

    The x-ray structure of a C-terminal fragment of the RAP74 subunit of human transcription factor (TF) IIF has been determined at 1.02-{angstrom} resolution. The {alpha}/{beta} structure is strikingly similar to the globular domain of linker histone H5 and the DNA-binding domain of hepatocyte nuclear factor 3{gamma} (HNF-3{gamma}), making it a winged-helix protein. The surface electrostatic properties of this compact domain differ significantly from those of bona fide winged-helix transcription factors (HNF-3{gamma} and RFX1) and from the winged-helix domains found within the RAP30 subunit of TFIIF and the {beta} subunit of TFIIE. RAP74 has been shown to interact with the TFIIF-associated C-terminal domain phosphatase FCP1, and a putative phosphatase binding site has been identified within the RAP74 winged-helix domain.

  7. THERAPIE - THErmix-RAps-Plot-InterfacE. A graphic software for representation of THERMIX-2D results with the interactive plot program RAPS

    International Nuclear Information System (INIS)

    Duensing, P.; Jahn, W.; Rehm, W.

    1986-09-01

    The performance of safety analyses for gas-cooled high temperature reactor power plants requires efficient plot codes for the evaluation and representation of computer results. The report describes the coupling between the thermodynamic simulation code THERMIX and the graphic plot code RAPS via the interface program THERAPIE. Especially the structure and the handling of the interface program are explained as well as the dialogue with the plot code. Further options of the colour graphic system are demonstrated for the representation of temperature distributions in components of HTR concepts (HTR-500). (orig.) [de

  8. C3G knock-down enhances migration and invasion by increasing Rap1-mediated p38α activation, while it impairs tumor growth through p38α-independent mechanisms

    Science.gov (United States)

    Priego, Neibla; Arechederra, María; Sequera, Celia; Bragado, Paloma; Vázquez-Carballo, Ana; Gutiérrez-Uzquiza, Álvaro; Martín-Granado, Víctor; Ventura, Juan José; Kazanietz, Marcelo G.; Guerrero, Carmen; Porras, Almudena

    2016-01-01

    C3G, a Guanine nucleotide Exchange Factor (GEF) for Rap1 and R-Ras, has been shown to play important roles in development and cancer. Previous studies determined that C3G regulates cell death through down-regulation of p38α MAPK activity. Here, we found that C3G knock-down in MEFs and HCT116 cells promotes migration and invasion through Rap1-mediated p38α hyper-activation. These effects of C3G were inhibited by Rap1 knock-down or inactivation. The enhanced migration observed in C3G depleted HCT116 cells was associated with reduction in E-cadherin expression, internalization of ZO-1, actin cytoskeleton reorganization and decreased adhesion. We also found that matrix metalloproteases MMP2 and MMP9 are involved in the pro-invasive effect of C3G down-regulation. Additionally, our studies revealed that both C3G and p38α collaborate to promote growth of HCT116 cells in vitro and in vivo, possibly by enhancing cell survival. In fact, knocking-down C3G or p38α individually or together promoted cell death in vitro, although only the double C3G-p38α silencing was able to increase cell death within tumors. Notably, we found that the pro-tumorigenic function of C3G does not depend on p38α or Rap1 activation. Altogether, our studies uncover novel mechanisms by which C3G controls key aspects of tumorigenesis. PMID:27286263

  9. Strong conservation of rhoptry-associated-protein-1 (RAP-1) locus organization and sequence among Babesia isolates infecting sheep from China (Babesia motasi-like phylogenetic group).

    Science.gov (United States)

    Niu, Qingli; Valentin, Charlotte; Bonsergent, Claire; Malandrin, Laurence

    2014-12-01

    Rhoptry-associated-protein 1 (RAP-1) is considered as a potential vaccine candidate due to its involvement in red blood cell invasion by parasites in the genus Babesia. We examined its value as a vaccine candidate by studying RAP-1 conservation in isolates of Babesia sp. BQ1 Ningxian, Babesia sp. Tianzhu and Babesia sp. Hebei, responsible for ovine babesiosis in different regions of China. The rap-1 locus in these isolates has very similar features to those described for Babesia sp. BQ1 Lintan, another Chinese isolate also in the B. motasi-like phylogenetic group, namely the presence of three types of rap-1 genes (rap-1a, rap-1b and rap-1c), multiple conserved rap-1b copies (5) interspaced with more or less variable rap-1a copies (6), and the 3' localization of one rap-1c. The isolates Babesia sp. Tianzhu, Babesia sp. BQ1 Lintan and Ningxian were almost identical (average nucleotide identity of 99.9%) over a putative locus of about 31 Kb, including the intergenic regions. Babesia sp. Hebei showed a similar locus organization but differed in the rap-1 locus sequence, for each gene and intergenic region, with an average nucleotide identity of 78%. Our results are in agreement with 18S rDNA phylogenetic studies performed on these isolates. However, in extremely closely related isolates the rap-1 locus seems more conserved (99.9%) than the 18S rDNA (98.7%), whereas in still closely related isolates the identities are much lower (78%) compared with the 18S rDNA (97.7%). The particularities of the rap-1 locus in terms of evolution, phylogeny, diagnosis and vaccine development are discussed. Copyright © 2014 The Authors. Published by Elsevier B.V. All rights reserved.

  10. Effects of using nursing home residents to serve as group activity leaders: lessons learned from the RAP project.

    Science.gov (United States)

    Skrajner, Michael J; Haberman, Jessica L; Camp, Cameron J; Tusick, Melanie; Frentiu, Cristina; Gorzelle, Gregg

    2014-03-01

    Previous research has demonstrated that persons with early to moderate stage dementia are capable of leading small group activities for persons with more advanced dementia. In this study, we built upon this previous work by training residents in long-term care facilities to fill the role of group activity leaders using a Resident-Assisted Programming (RAP) training regimen. There were two stages to the program. In the first stage, RAP training was provided by researchers. In the second stage, RAP training was provided to residents by activities staff members of long-term care facilities who had been trained by researchers. We examine the effects of RAP implemented by researchers and by activities staff member on long-term care resident with dementia who took part in these RAP activities. We also examined effects produced by two types of small group activities: two Montessori-based activities and an activity which focuses on persons with more advanced dementia, based on the work of Jitka Zgola. Results demonstrate that levels of positive engagement seen in players during RAP (resident-led activities) were typically higher than those observed during standard activities programming led by site staff. In general, Montessori-Based Dementia Programming® produced more constructive engagement than Zgola-based programming (ZBP), though ZBP did increase a positive form of engagement involving observing activities with interest. In addition, RAP implemented by activities staff members produced effects that were, on the whole, similar to those produced when RAP was implemented by researchers. Implications of these findings for providing meaningful social roles for persons with dementia residing in long-term care, and suggestions for further research in this area, are discussed.

  11. Investigation on the Combined Effect of Fibers and Cement on the Mechanical Performance of Foamed Bitumen Mixtures Containing 100% RAP

    OpenAIRE

    Ehsan Ashouri Taziani; Emanuele Toraldo; Filippo Giustozzi; Maurizio Crispino

    2016-01-01

    Concerns about virgin aggregate sources and increasing demands for construction materials of transport infrastructures as the key parameters in development are the most important reasons, which convinced pavement engineers to develop new methods in order to use higher amount of recycled asphalt pavement (RAP). One of the common methodologies to produce mixtures containing RAP is foamed bitumen mix (FBM). In addition, according to previous research studies, incorporating various types of fiber...

  12. RAPS: an innovative active pixel for particle detection integrated in CMOS technology

    International Nuclear Information System (INIS)

    Passeri, Daniele; Placidi, Pisana; Verducci, Leonardo; Ciampolini, Paolo; Matrella, Guido; Marras, Alessandro; Bilei, G.M.

    2004-01-01

    In this paper we discuss some design, implementation and test issues, with respect to the development of the RAPS01 chip in the framework of the Radiation Active Pixel Sensors (RAPS) INFN project. The project aimed at verifying feasibility of smart, high-resolution pixel arrays with a fully standard, submicron CMOS technology for particle detection purposes. Layout optimization of the pixel, including sensitive element and local read and amplification circuits has been carried out. Different basic pixel schemes and read-out options have been proposed and devised. Chip fabrication has been completed and test phase is now under way: to this purpose a suitable test environment has been devised and test strategies have been planned

  13. Physics evaluation for testino. of RAPS and TAPS fuel pins in CIRUS pressurised water loop

    International Nuclear Information System (INIS)

    John, Benjamin; Paul, O.P.K.

    1976-01-01

    Relevant calculations carried out to assess the reactivity effect, heat generation and other parameters for testing of RAPS and TAPS fuel pins in the Cirus pressurised water loop are summarised. The Cirus neutron flux level being low, in order to simulate the RAPS design heat rating of ∫ Kdtheta = 40 w/cm, the required plutonium enrichment in mixed plutonium uranium oxide fuel pin was worked out. The results showed that a PuO 2 enrichment of 1.5 wt percent would be necessary to meet the above requirement. The analysis for the TAPS pin indicated that the desired heat flux of 115w/cm 2 cannot be obtained in the Cirus loop with either a 7 pin cluster geometry, or with a single pin with the enrichment level as used in TAPS pin. Lattice code DUMLAC and the core simulation code AECLHEX were used for these studies. (author)

  14. A educação informal e o rap como agente educativo

    Directory of Open Access Journals (Sweden)

    Alexandre Felipe Fiuza

    2013-01-01

    Full Text Available In this text are broached the relationship between rap music and the educational processes. To achieve this goal, the study deals with the conceptualization of the modalities of education, namely formal, non-formal and informal education, based on national and foreign bibliography. Considering the object of study, this paper is based on interdisciplinary reflections, consisting of theoretical and methodological approaches from the fields of Education, Music, Communication and Sociology of Culture. These theoretical frameworks contribute to the accuracy of concepts and the observation of the multiple dimensions that hip hop, and specifically rap, holds as a social and cultural phenomenon. By focusing on the particularity of informal education, which is even more prevalent in the so-called knowledge or media society, this study aims to contribute to the discussion of educational processes intrinsic to the culture industry and the media, and their significant influence on the audience.

  15. RAP-2A Computer code for transients analysis in fast reactors

    International Nuclear Information System (INIS)

    Iftode, I.; Popescu, C.; Turcu, I.; Biro, L.

    1975-10-01

    The RAP-2A computer code is designed for analyzing thermohydraulic transients and/or steady state problems for large LMFBR cores. Physical and mathematical models, main input-output data, the flow chart of the code and a sample problem are given. RAP-2A calculates the power and the thermoydraulic transients initiated by a flow or reactivity changes, from a normal operating state of the reactor up to core disassembly. In this analysis a representative fuel pin is considered: a one-group space-independent (point) kinetics model to describe the neutron kinetics and a one-dimensional model describing the heat transfer (radial in the fuel and axial in the coolant) are used. Mechanical deformations due to temperature gradient, pressure losses, fuel melting, etc., are also calculated. The code is written in FORTRAN-4 language and is running on a IBM-370/135 computer

  16. Radiosensitivity of the swiss-rap mouse as a function of its growth rate

    International Nuclear Information System (INIS)

    Legeay, G.; Glas, J.F.

    1969-01-01

    The results of an exhaustive study of the age dependence of the radiosensitivity of female Swiss-Rap mice are given. A close relationship of radiosensitivity versus age could not be brought out, whereas the weekly growth rate could be accurately related to radiosensitivity. Thus, the latter should be studied when a strain is to be used for biological experiments, as the rates of growth are different with the strains. (author) [fr

  17. RAP: RNA-Seq Analysis Pipeline, a new cloud-based NGS web application.

    Science.gov (United States)

    D'Antonio, Mattia; D'Onorio De Meo, Paolo; Pallocca, Matteo; Picardi, Ernesto; D'Erchia, Anna Maria; Calogero, Raffaele A; Castrignanò, Tiziana; Pesole, Graziano

    2015-01-01

    The study of RNA has been dramatically improved by the introduction of Next Generation Sequencing platforms allowing massive and cheap sequencing of selected RNA fractions, also providing information on strand orientation (RNA-Seq). The complexity of transcriptomes and of their regulative pathways make RNA-Seq one of most complex field of NGS applications, addressing several aspects of the expression process (e.g. identification and quantification of expressed genes and transcripts, alternative splicing and polyadenylation, fusion genes and trans-splicing, post-transcriptional events, etc.). In order to provide researchers with an effective and friendly resource for analyzing RNA-Seq data, we present here RAP (RNA-Seq Analysis Pipeline), a cloud computing web application implementing a complete but modular analysis workflow. This pipeline integrates both state-of-the-art bioinformatics tools for RNA-Seq analysis and in-house developed scripts to offer to the user a comprehensive strategy for data analysis. RAP is able to perform quality checks (adopting FastQC and NGS QC Toolkit), identify and quantify expressed genes and transcripts (with Tophat, Cufflinks and HTSeq), detect alternative splicing events (using SpliceTrap) and chimeric transcripts (with ChimeraScan). This pipeline is also able to identify splicing junctions and constitutive or alternative polyadenylation sites (implementing custom analysis modules) and call for statistically significant differences in genes and transcripts expression, splicing pattern and polyadenylation site usage (using Cuffdiff2 and DESeq). Through a user friendly web interface, the RAP workflow can be suitably customized by the user and it is automatically executed on our cloud computing environment. This strategy allows to access to bioinformatics tools and computational resources without specific bioinformatics and IT skills. RAP provides a set of tabular and graphical results that can be helpful to browse, filter and export

  18. Degrees of Intersectionality: Male Rap Artists in Sweden Negotiating Class, Race and Gender

    OpenAIRE

    Kalle Berggren

    2013-01-01

    “Intersectionality” has become a highly influential concept in gender research over the last 25 years. Debates have focused on differences and power asymmetries between women, in terms of race but also addressing class, age, sexuality, ability and nation. However, intersectional paradigms have been used to a much lesser extent in gender studies on men. This article seeks to contribute to an emerging discussion about intersectionality and masculinity by analyzing rap lyrics in Swe-dish songs. ...

  19. Re-active Passive (RAP) Devices for Control of Noise Transmission through a Panel

    Science.gov (United States)

    Carneal, James P.; Giovanardi, Marco; Fuller, Chris R.; Palumbo, Daniel L.

    2008-01-01

    Re-Active Passive (RAP) devices have been developed to control low frequency (transmission through a panel. These devices use a combination of active, re-active, and passive technologies packaged into a single unit to control a broad frequency range utilizing the strength of each technology over its best suited frequency range. The RAP device uses passive constrained layer damping to cover the relatively high frequency range (>200 Hz), reactive distributed vibration absorber) to cover the medium frequency range (75 to 250 Hz), and active control for controlling low frequencies (transmission through a panel mounted in a transmission loss test facility. Experimental results are presented for the bare panel, and combinations of passive treatment, reactive treatment, and active control. Results indicate that three RAP devices were able to increase the overall broadband (15-1000 Hz) transmission loss by 9.4 dB. These three devices added a total of 285 grams to the panel mass of 6.0 kg, or approximately 5%, not including control electronics.

  20. O rap radical e a "nova classe média"

    Directory of Open Access Journals (Sweden)

    Ricardo Indig Teperman

    2015-04-01

    Full Text Available Este artigo discute a recente alteração na posição relativa do rap e dos rappers no campo da produção cultural no Brasil. O grupo Racionais MCs, tão central no campo do rap nacional que acaba por determinar a tendência hegemônica do gênero, vem se afastando do posicionamento revolucionário que marcou seus primeiros anos. Proponho que o aumento do poder de consumo e a democratização do acesso à tecnologia e à educação são aspectos que marcam a experiência da nova geração do rap (a chamada "nova escola", personificada em Emicida, e que provocaram o reposicionamento do Racionais. Recupero uma formulação de Antonio Candido para propor que essa nova posição pode ser considerada "radical".

  1. Frequency of helicobacter pylori (hp) infection in children with recurrent abdominal pain (rap)

    International Nuclear Information System (INIS)

    Mahmud, S.; Ali, S.

    2015-01-01

    To study the frequency of Helicobacter Pylori (HP) infection among children with recurrent abdominal pain (RAP) Study Design: Cross-sectional comparative study. Place and Duration of Study: Military Hospital (MH), Rawalpindi from December 2011 to February 2012. Patients and Methods: One hundred children of either gender aged 2 to 12 years presenting with RAP were tested for HP at Paediatric OPD MH, Rawalpindi who consented to participate in the study. Those children who tested positive for Helicobacter Pylori Stool Antigen Test (HPSAT) were labeled as those having Hp infection. The stool assay was performed using the HpSAT kit and the socio-demographic and clinical profiles of children were associated. Results: Out of 100 children included in the study HpSAT was positive in 38% children. Frequency of Hp infection was significantly associated with source of drinking water (p = 0.014), socioeconomic status (p = 0.001) and positive family history of yspepsia (p= 0.023). While age and gender have no significant association with HP infection. Conclusion: Hp infection is very common in children presenting with RAP in our Paediatric OPD. Children with family history of dyspepsia, from low socioeconomic class and those drinking filtered water are at greater risk for HP infection. It is recommended that children from other populations in our country should also be tested in their medical health facilities in order to have a wider analysis of this problem in our setup. (author)

  2. CDK5RAP2 gene and tau pathophysiology in late-onset sporadic Alzheimer's disease.

    Science.gov (United States)

    Miron, Justin; Picard, Cynthia; Nilsson, Nathalie; Frappier, Josée; Dea, Doris; Théroux, Louise; Poirier, Judes

    2018-06-01

    Because currently known Alzheimer's disease (AD) single-nucleotide polymorphisms only account for a small fraction of the genetic variance in this disease, there is a need to identify new variants associated with AD. Our team performed a genome-wide association study in the Quebec Founder Population isolate to identify novel protective or risk genetic factors for late-onset sporadic AD and examined the impact of these variants on gene expression and AD pathology. The rs10984186 variant is associated with an increased risk of developing AD and with a higher CDK5RAP2 mRNA prevalence in the hippocampus. On the other hand, the rs4837766 variant, which is among the best cis-expression quantitative trait loci in the CDK5RAP2 gene, is associated with lower mild cognitive impairment/AD risk and conversion rate. The rs10984186 risk and rs4837766 protective polymorphic variants of the CDK5RAP2 gene might act as potent genetic modifiers for AD risk and/or conversion by modulating the expression of this gene. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

  3. Evaluation of the RapID-ANA system for identification of anaerobic bacteria of veterinary origin.

    Science.gov (United States)

    Adney, W S; Jones, R L

    1985-12-01

    This study evaluated the ability of the RapID-ANA system (Innovative Diagnostic Systems, Inc., Atlanta, Ga.) to accurately identify a spectrum of freshly isolated veterinary anaerobes. A total of 183 isolates were tested and included 7 Actinomyces spp., 53 Bacteroides spp., 32 Clostridium spp., 2 Eubacterium spp., 65 Fusobacterium spp., 1 Peptococcus spp., 22 Peptostreptococcus spp., and 1 Propionibacterium spp. All isolates were initially identified by conventional biochemical testing and gas-liquid chromatography of short-chain fatty acid metabolites. Additional tests were performed as required by the RapID-ANA system. Of these isolates, 81.4% were correctly identified to the genus level, including 59.6% to the species level, 14.2% were incorrectly identified at the genus level, and 4.4% were not identified. Initially, 20.2% of the strains were not identified because the microcodes were not in the code book. The majority of the incorrect identifications were caused by the misidentification of Fusobacterium spp. as Bacteroides spp. Errors also occurred when veterinary anaerobes not included in the data base were assigned an identification from the existing data base. The RapID-ANA system appears to be a promising new method for rapid identification of veterinary anaerobes; however, further evaluation with an extended data base is needed before the system can accurately identify all clinically significant anaerobes.

  4. Part D Reconsideration Appeals Fact Sheets

    Data.gov (United States)

    U.S. Department of Health & Human Services — If a Part D plan sponsor issues an adverse redetermination decision, the enrollee or the enrollees representative may appeal the decision to the Independent Review...

  5. 7 CFR 1951.896 - Appeals.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 14 2010-01-01 2009-01-01 true Appeals. 1951.896 Section 1951.896 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... 1900 of this chapter. ...

  6. Pandemic ventilator rationing and appeals processes.

    Science.gov (United States)

    Patrone, Daniel; Resnik, David

    2011-06-01

    In a severe influenza pandemic, hospitals will likely experience serious and widespread shortages of patient pulmonary ventilators and of staff qualified to operate them. Deciding who will receive access to mechanical ventilation will often determine who lives and who dies. This prospect raises an important question whether pandemic preparedness plans should include some process by which individuals affected by ventilator rationing would have the opportunity to appeal adverse decisions. However, the issue of appeals processes to ventilator rationing decisions has been largely neglected in state pandemic planning efforts. If we are to devise just and effective plans for coping with a severe influenza pandemic, more attention to the issue of appeals processes for pandemic ventilator rationing decisions is needed. Arguments for and against appeals processes are considered, and some suggestions are offered to help efforts at devising more rational pandemic preparedness plans.

  7. Guilt decreasing marketing communication: an unexplored appeal

    OpenAIRE

    B. BUSACCA; SOSCIA I; PITRELLI E

    2007-01-01

    The phenomenon of guilt is relevant to a variety of consumption situations and practitioners around the world have continued to use it as a communication appeal. Marketing literature demonstrated that guilt as a distinct emotion can be aroused by advertising. Nevertheless, the capacity of advertising to decrease guilt was neglected by marketing scholars and the aim of this research is to assess the role of the guilt decreasing appeal in reducing anticipated guilt. Findings demonstrate the eff...

  8. Appeals to AC as a Percentage of Appealable Hearing Level Dispositions

    Data.gov (United States)

    Social Security Administration — Longitudinal report detailing the numbers and percentages of Requests for Review (RR) of hearing level decisions or dismissals filed with the Appeals Council (AC)...

  9. 43 CFR 4.704 - Decisions on appeals.

    Science.gov (United States)

    2010-10-01

    ... Ad Hoc Appeals Board appointed by the Director to consider and decide the particular appeal, will... Board may direct a hearing on the entire matter or specified portions thereof, may decide the appeal... by an administrative law judge of the Office of Hearings and Appeals and shall be governed insofar as...

  10. 32 CFR 1900.41 - Establishment of appeals structure.

    Science.gov (United States)

    2010-07-01

    ... Administrative Appeals § 1900.41 Establishment of appeals structure. (a) In general. Two administrative entities... 32 National Defense 6 2010-07-01 2010-07-01 false Establishment of appeals structure. 1900.41... administrative appeals under the Freedom of Information Act. Their membership, authority, and rules of procedure...

  11. 7 CFR 1900.54 - Effect on assistance pending appeal.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false Effect on assistance pending appeal. 1900.54 Section... assistance pending appeal. (a) Assistance will not be discontinued pending the outcome of an appeal of a..., administrative offsets initiated under subpart C of part 1951 will not be stayed pending the outcome of an appeal...

  12. 4 CFR 22.4 - Appeal File [Rule 4].

    Science.gov (United States)

    2010-01-01

    ... alternative organization of the appeal file is permitted, such as by document type or topic, documents within... 4 Accounts 1 2010-01-01 2010-01-01 false Appeal File [Rule 4]. 22.4 Section 22.4 Accounts... OFFICE CONTRACT APPEALS BOARD § 22.4 Appeal File [Rule 4]. (a) Duties of the Contracting Officer. (1...

  13. 7 CFR 29.91 - How to obtain an appeal.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false How to obtain an appeal. 29.91 Section 29.91... REGULATIONS TOBACCO INSPECTION Regulations Appeal § 29.91 How to obtain an appeal. An appeal shall be made in writing and filed with the Division or the office of inspection for the type of tobacco involved. Such...

  14. 77 FR 58941 - Appeal Proceedings Before the Commission

    Science.gov (United States)

    2012-09-25

    ... forth more specific rules for the different types of appeals. Rules for appeals of ordinance..., 582, 583, 584, and 585 RIN 3141-AA47 Appeal Proceedings Before the Commission AGENCY: National Indian... Commission) promulgates this final rule to enhance and clarify appeal proceedings before the Commission. This...

  15. 7 CFR 70.105 - Procedures for appeal gradings.

    Science.gov (United States)

    2010-01-01

    ... conducting the appeal grading. Whether defrosting poultry or rabbit carcasses for other types of appeals will... 7 Agriculture 3 2010-01-01 2010-01-01 false Procedures for appeal gradings. 70.105 Section 70.105... PRODUCTS AND RABBIT PRODUCTS Grading of Poultry Products and Rabbit Products Appeal of A Grading Or...

  16. 34 CFR 668.214 - Participation rate index appeals.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Participation rate index appeals. 668.214 Section 668... § 668.214 Participation rate index appeals. (a) Eligibility. (1) You may appeal a notice of a loss of... rate index for that cohort's fiscal year is equal to or less than 0.06015. (2) You may appeal a notice...

  17. 34 CFR 668.195 - Participation rate index appeals.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Participation rate index appeals. 668.195 Section 668... Rates § 668.195 Participation rate index appeals. (a) Eligibility. (1) You may appeal a notice of a loss... participation rate index for that cohort's fiscal year is equal to or less than 0.06015. (2) You may appeal a...

  18. 50 CFR 679.43 - Determinations and appeals.

    Science.gov (United States)

    2010-10-01

    ... determinations made under § 679.30(d). (b) Who may appeal. Any person whose interest is directly and adversely affected by an initial administrative determination may file a written appeal. For purposes of this section..., Attention: Appeals (OAA), 709 W. 9th Street, Room 453, Juneau, AK 99801. (d) Timing of appeals. (1) If an...

  19. Guilt appeals in advertising: what are their effects?

    Science.gov (United States)

    Coulter, R H; Pinto, M B

    1995-12-01

    This study examined consumers' emotional responses, their attitudes toward advertisements and brands, attributions about the companies promoting the brands, and purchase intention for ads varying on level of guilt appeal. Sixty working mothers, a prime target of guilt appeals, participated in the study. Results indicated that moderate guilt appeals elicited more felt guilt in the working mothers than did low or high guilt appeals. Furthermore, emotional responses, particularly anger, mediated the relationship between level of guilt appeal and consumers' attitudes and corporate attributions, and an inverse relationship occurred between level of guilt appeal and attitudes and attributions. Purchase intention was affected by the level of the guilt appeal and by anger.

  20. Case note: Supreme Court of Canada (Prime Minister and ors v Khadr (Omar Ahmed), Amnesty International (Canadian Section, English Branch) (intervening) and ors (intervening), Final appeal judgment, 2010 SCC 3)

    NARCIS (Netherlands)

    Clarke, L.

    2010-01-01

    Whether the principles of international law and comity that normally precluded application of the Constitution Act, 1982(‘Canadian Charter’) to Canadian officials acting abroad applied to the assistance they provided to US authorities at Guantánamo Bay. Whether the deprivation of the liberty and

  1. Breast cancer cell migration is regulated through junctional adhesion molecule-A-mediated activation of Rap1 GTPase

    LENUS (Irish Health Repository)

    McSherry, Elaine A

    2011-03-23

    Abstract Introduction The adhesion protein junctional adhesion molecule-A (JAM-A) regulates epithelial cell morphology and migration, and its over-expression has recently been linked with increased risk of metastasis in breast cancer patients. As cell migration is an early requirement for tumor metastasis, we sought to identify the JAM-A signalling events regulating migration in breast cancer cells. Methods MCF7 breast cancer cells (which express high endogenous levels of JAM-A) and primary cultures from breast cancer patients were used for this study. JAM-A was knocked down in MCF7 cells using siRNA to determine the consequences for cell adhesion, cell migration and the protein expression of various integrin subunits. As we had previously demonstrated a link between the expression of JAM-A and β1-integrin, we examined activation of the β1-integrin regulator Rap1 GTPase in response to JAM-A knockdown or functional antagonism. To test whether JAM-A, Rap1 and β1-integrin lie in a linear pathway, we tested functional inhibitors of all three proteins separately or together in migration assays. Finally we performed immunoprecipitations in MCF7 cells and primary breast cells to determine the binding partners connecting JAM-A to Rap1 activation. Results JAM-A knockdown in MCF7 breast cancer cells reduced adhesion to, and migration through, the β1-integrin substrate fibronectin. This was accompanied by reduced protein expression of β1-integrin and its binding partners αV- and α5-integrin. Rap1 activity was reduced in response to JAM-A knockdown or inhibition, and pharmacological inhibition of Rap1 reduced MCF7 cell migration. No additive anti-migratory effect was observed in response to simultaneous inhibition of JAM-A, Rap1 and β1-integrin, suggesting that they lie in a linear migratory pathway. Finally, in an attempt to elucidate the binding partners putatively linking JAM-A to Rap1 activation, we have demonstrated the formation of a complex between JAM-A, AF-6

  2. Breast cancer cell migration is regulated through junctional adhesion molecule-A-mediated activation of Rap1 GTPase.

    LENUS (Irish Health Repository)

    McSherry, Elaine A

    2011-03-23

    ABSTRACT: INTRODUCTION: The adhesion protein junctional adhesion molecule-A (JAM-A) regulates epithelial cell morphology and migration, and its over-expression has recently been linked with increased risk of metastasis in breast cancer patients. As cell migration is an early requirement for tumor metastasis, we sought to identify the JAM-A signalling events regulating migration in breast cancer cells. METHODS: MCF7 breast cancer cells (which express high endogenous levels of JAM-A) and primary cultures from breast cancer patients were used for this study. JAM-A was knocked down in MCF7 cells using siRNA to determine the consequences for cell adhesion, cell migration and the protein expression of various integrin subunits. As we had previously demonstrated a link between the expression of JAM-A and β1-integrin, we examined activation of the β1-integrin regulator Rap1 GTPase in response to JAM-A knockdown or functional antagonism. To test whether JAM-A, Rap1 and β1-integrin lie in a linear pathway, we tested functional inhibitors of all three proteins separately or together in migration assays. Finally we performed immunoprecipitations in MCF7 cells and primary breast cells to determine the binding partners connecting JAM-A to Rap1 activation. RESULTS: JAM-A knockdown in MCF7 breast cancer cells reduced adhesion to, and migration through, the β1-integrin substrate fibronectin. This was accompanied by reduced protein expression of β1-integrin and its binding partners αV- and α5-integrin. Rap1 activity was reduced in response to JAM-A knockdown or inhibition, and pharmacological inhibition of Rap1 reduced MCF7 cell migration. No additive anti-migratory effect was observed in response to simultaneous inhibition of JAM-A, Rap1 and β1-integrin, suggesting that they lie in a linear migratory pathway. Finally, in an attempt to elucidate the binding partners putatively linking JAM-A to Rap1 activation, we have demonstrated the formation of a complex between JAM-A, AF

  3. Breast cancer cell migration is regulated through junctional adhesion molecule-A-mediated activation of Rap1 GTPase.

    LENUS (Irish Health Repository)

    McSherry, Elaine A

    2012-02-01

    INTRODUCTION: The adhesion protein junctional adhesion molecule-A (JAM-A) regulates epithelial cell morphology and migration, and its over-expression has recently been linked with increased risk of metastasis in breast cancer patients. As cell migration is an early requirement for tumor metastasis, we sought to identify the JAM-A signalling events regulating migration in breast cancer cells. METHODS: MCF7 breast cancer cells (which express high endogenous levels of JAM-A) and primary cultures from breast cancer patients were used for this study. JAM-A was knocked down in MCF7 cells using siRNA to determine the consequences for cell adhesion, cell migration and the protein expression of various integrin subunits. As we had previously demonstrated a link between the expression of JAM-A and beta1-integrin, we examined activation of the beta1-integrin regulator Rap1 GTPase in response to JAM-A knockdown or functional antagonism. To test whether JAM-A, Rap1 and beta1-integrin lie in a linear pathway, we tested functional inhibitors of all three proteins separately or together in migration assays. Finally we performed immunoprecipitations in MCF7 cells and primary breast cells to determine the binding partners connecting JAM-A to Rap1 activation. RESULTS: JAM-A knockdown in MCF7 breast cancer cells reduced adhesion to, and migration through, the beta1-integrin substrate fibronectin. This was accompanied by reduced protein expression of beta1-integrin and its binding partners alphaV- and alpha5-integrin. Rap1 activity was reduced in response to JAM-A knockdown or inhibition, and pharmacological inhibition of Rap1 reduced MCF7 cell migration. No additive anti-migratory effect was observed in response to simultaneous inhibition of JAM-A, Rap1 and beta1-integrin, suggesting that they lie in a linear migratory pathway. Finally, in an attempt to elucidate the binding partners putatively linking JAM-A to Rap1 activation, we have demonstrated the formation of a complex between

  4. Development of low-cost open source 3D gel printer "RepRap SWIM-ER"

    Science.gov (United States)

    Sato, Kei; Basher, Samiul; Ota, Takafumi; Tase, Taishi; Takamatsu, Kyuichiro; Saito, Azusa; Khosla, Ajit; Kawakami, Masaru; Furuawa, Hidemitsu

    2017-04-01

    Gels are soft and wet materials having low friction, good biocompatibility, and material permeability. It is expected that gel materials will be used as new kinds of industrial materials in the engineering and medical applications. But it cannot build a complicated shape. Soft & Wet Matter Engineering Laboratory developed a 3D gel Printer "SWIM-ER", has enabled modeling of complex shapes of the gel. However, this is expensive. Therefore not all of the gel researchers and the companies have such a device. To solve this problem, we manufacture a low-cost open-source 3D gel printer "RepRap SWIM-ER" from the RepRap. We made the components required to manufacture the "RepRap SWIM-ER" from the 3D printer and chose a light source. In addition, we produced the P-DN gel for RepRap SWIM-ER and conducted the molding test to confirm whether RepRap SWIM-ER can used it.

  5. Classification analysis of emotional appeals on sample Czech television commercials

    OpenAIRE

    Káčerková, Radka

    2013-01-01

    Abstract: The work deals with the possibilities of using emotional appeals in advertising. The main goal was classification and definition of emotions and emotional appeals with regard to marketing. The work focused on emotional appeals in Czech TV adverts and found out the way how emotional appeals are used in these adverts. Research question used in this work concerned the problem of which emmotional appeals are in adverts the most. Research sample consisting of 150 TV adverts was divided i...

  6. 75 FR 64655 - Interior Board of Land Appeals and Other Appeals Procedures

    Science.gov (United States)

    2010-10-20

    ... consolidation of appeals, requests for extensions of time, motions, and intervention, which are all familiar... regulations governing consolidation, extensions of time, intervention, and motions in IBLA appeals; removing... regulations governing motions for consolidation, extensions of time, and intervention, and for serving and...

  7. Remote ultrasonic characterisation of an irradiated pressure tube from RAPS-II

    Energy Technology Data Exchange (ETDEWEB)

    Gangotra, S; Muralidhar, S; Raut, S D; Ouseph, P M; Ghosh, J K; Sahoo, K C [Bhabha Atomic Research Centre, Bombay (India). Radiometallurgy Div.

    1994-12-31

    The Rajasthan Atomic Power Station Unit-2 (RAPS-2) has reached a stage of operation where the contacting pressure tubes are suspect to failure as a result of irradiation creep and displacement of the garter springs, the hot pressure tube coming in contact with the cold calandria tube. To study and assess the safety of these pressure tubes, two channels believed to be in contact with the calandria tubes, have been removed from the reactor for detailed full length post irradiation examination. Some of the test results are presented. 2 refs., 3 figs., 1 tab.

  8. Operating experience and radiation protection in RAPS-3 and 4 operations

    International Nuclear Information System (INIS)

    Khandelwal, Narendra; Dhakar, P.C.; Singh, G.K.; Gupta, Ashok

    2008-01-01

    Rajasthan Atomic Power Station (RAPS)-3 and 4 was designed and constructed using latest technological advancements in the field of nuclear energy. Operating experience of the station have taught many lessons and provided opportunities to take proactive corrective actions. Design modifications, effective implementation of radiological surveillance program and improvements in work culture have helped in achieving continual reduction in radiation exposures and effluent releases at the station. This paper discusses some of the modifications carried out at the station along with their radiological impacts. (author)

  9. Effect of Bio based rejuvenator on mix design, Energy consumption and GHG Emission of High RAP Mixture

    Science.gov (United States)

    Abdullahi Ahmad, Kabiru; Ezree Abdullah, Mohd; Hassan, Norhidayah Abdul; Usman, Nura; Hassan, Mohd Rosli Mohd; Bilema, Munder A. M.; Modibbo Saeed, Saeed; Batari, Ahmad

    2018-04-01

    Concerns about the cost, availability, and environmental impact of using petroleum-based materials have led to increased usage of reclaimed asphalt pavement (RAP). Mean-while, the demand of the road industry to decrease the energy consumptions and reduce the release of greenhouse gases as well as other harmful gases, which cause serious air pollution has increased due to the amount of energy consumed is a major component of pavement construction that significantly contributes to the total cost. This paper evaluates the effects of Biobased rejuvenator known as JCO on the required heat energy and the amount of CO2 produced to increase the temperature of RAP and virgin aggregates and one binder from 25C to the point of mixing. The results showed that incorporating Biobased rejuvenator (JCO) can potentially reduce the required heat energy and amount of greenhouse gas produced by RAP and virgin, respectively.

  10. Investigation on the Combined Effect of Fibers and Cement on the Mechanical Performance of Foamed Bitumen Mixtures Containing 100% RAP

    Directory of Open Access Journals (Sweden)

    Ehsan Ashouri Taziani

    2016-01-01

    Full Text Available Concerns about virgin aggregate sources and increasing demands for construction materials of transport infrastructures as the key parameters in development are the most important reasons, which convinced pavement engineers to develop new methods in order to use higher amount of recycled asphalt pavement (RAP. One of the common methodologies to produce mixtures containing RAP is foamed bitumen mix (FBM. In addition, according to previous research studies, incorporating various types of fibers and hydraulic binders such as cement could significantly improve the mechanical performance of mixtures. The present research study evaluated FBM containing 100% RAP and two types of fiber and Portland cement. Dynamic modulus, unconfined dynamic creep compression, and indirect tensile strength were evaluated in the laboratory at optimum moisture content, which was investigated in this research. Both types of fiber and cement proved to enhance specific properties of mixtures.

  11. Cep169, a Novel Microtubule Plus-End-Tracking Centrosomal Protein, Binds to CDK5RAP2 and Regulates Microtubule Stability.

    Directory of Open Access Journals (Sweden)

    Yusuke Mori

    Full Text Available The centrosomal protein, CDK5RAP2, is a microcephaly protein that regulates centrosomal maturation by recruitment of a γ-tubulin ring complex (γ-TuRC onto centrosomes. In this report, we identified a novel human centrosomal protein, Cep169, as a binding partner of CDK5RAP2, a member of microtubule plus-end-tracking proteins (+TIPs. Cep169 interacts directly with CDK5RAP2 through CM1, an evolutionarily conserved domain, and colocalizes at the pericentriolar matrix (PCM around centrioles with CDK5RAP2. In addition, Cep169 interacts with EB1 through SxIP-motif responsible for EB1 binding, and colocalizes with CDK5RAP2 at the microtubule plus-end. EB1-binding-deficient Cep169 abolishes EB1 interaction and microtubule plus-end attachment, indicating Cep169 as a novel member of +TIPs. We further show that ectopic expression of either Cep169 or CDK5RAP2 induces microtubule bundling and acetylation in U2OS cells, and depletion of Cep169 induces microtubule depolymerization in HeLa cells, although Cep169 is not required for assembly of γ-tubulin onto centrosome by CDK5RAP2. These results show that Cep169 targets microtubule tips and regulates stability of microtubules with CDK5RAP2.

  12. NGF-Dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway

    NARCIS (Netherlands)

    Lu, L.; Annerén, C.; Reedquist, K. A.; Bos, J. L.; Welsh, M.

    2000-01-01

    The Src homology 2 (SH2) domain adaptor protein Shb has been shown to transmit NGF- and FGF-2-dependent differentiation signals in PC12 cells. To study if this involves signaling through the small GTPase Rap1, Rap1 activity was assessed in Shb-overexpressing PC12 cells. We demonstrate that NGF and

  13. The transcription factor Rap1p is required for tolerance to cell-wall perturbing agents and for cell-wall maintenance in Saccharomyces cerevisiae.

    Science.gov (United States)

    Azad, Gajendra Kumar; Singh, Vikash; Baranwal, Shivani; Thakare, Mayur Jankiram; Tomar, Raghuvir S

    2015-01-02

    Yeast repressor activator protein (Rap1p) is involved in genomic stability and transcriptional regulation. We explored the function of Rap1p in yeast physiology using Rap1p truncation mutants. Our results revealed that the N-terminal truncation of Rap1p (Rap1ΔN) leads to hypersensitivity towards elevated temperature and cell-wall perturbing agents. Cell wall analysis showed an increase in the chitin and glucan content in Rap1ΔN cells as compared with wild type cells. Accordingly, mutant cells had a twofold thicker cell wall, as observed by electron microscopy. Furthermore, Rap1ΔN cells had increased levels of phosphorylated Slt2p, a MAP kinase of the cell wall integrity pathway. Mutant cells also had elevated levels of cell wall integrity response transcripts. Taken together, our findings suggest a connection between Rap1p and cell wall homeostasis. Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

  14. An Action Research Study on the Influence of Gangsta Rap on Academic and Behavioral Issues of 5th Grade African-American Males

    Science.gov (United States)

    Lewis, Shaun; Boes, Susan R.; Chibbaro, Julie S.

    2015-01-01

    This small action research study (ARS) began with a review of the literature examining the relationship of gangsta rap in regards to academic achievement, self-esteem, decision-making, identity issues and development of young African American males. The purpose of the ARS was to examine the correlation between gangsta rap and its influence on 5th…

  15. Outsourcing can have great appeal.

    Science.gov (United States)

    Turner, Martin

    2002-05-01

    Build, own, operate; energy performance contracting; asset acquisition and management. These are among latest trends in energy and facilities management. What they mean and how they apply to the health sector are subjects addressed in this article, which is based on an International Federation of Hospital Engineering Congress paper presented by Martin Turner, of Australia, for AGL Limited.

  16. Admissibility of appeals in atomic energy law

    International Nuclear Information System (INIS)

    Rengeling, H.W.

    1981-01-01

    Using two decisions made by the Federal Court of Administration on the Whyl reactor on July 17, 1980, and on the Stade reactor on December 22, 1980, which he considers as having at least an orientation effect, the author examines the admissibility of appeals filed according to the Atomic Energy Law. For substantiating the appeal, he discusses rules of law that protect third parties and the complainant's obligation to substantiate the appeal. In view of the preclusion of objectives, he differentiates between 'forfeiture' preclusion and 'validity' preclusion. In his view, the above-mentioned decisions produce effects that are to the benefit of the constitutional state and the necessary further development of economy and technology. (HSCH) [de

  17. 22 CFR 212.37 - Procedures for agency consideration of appeals.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Procedures for agency consideration of appeals. 212.37 Section 212.37 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT PUBLIC INFORMATION Access... of the decisions and of the provisions for judicial review of the Agency's denial of the request. (c...

  18. Apropriação musical: a arte de ouvir Rap

    Directory of Open Access Journals (Sweden)

    Jaison Hinkel

    2011-09-01

    Full Text Available Esta pesquisa teve por objetivo investigar se há e como se processa a relação estética entre sujeitos ouvintes e a música Rap, no processo de apropriação musical. Partimos da perspectiva sócio-histórica, segundo a qual nas reflexões metodológicas propostas por Vigotski estiveram tecidas as ideias de Bakhtin, como também as contribuições de Sartre, em um movimento dialógico com alguns leitores que se fazem interlocutores destes autores. Realizamos entrevistas individuais e abertas com cinco jovens moradores de periferia da região de Blumenau - SC. As análises indicaram a apropriação musical dos sujeitos investigados como um complexo processo que envolve aspectos referentes às propriedades físico-perceptuais do objeto estético Rap e a biografia de cada sujeito/ouvinte. A apropriação musical se mostrou como um complexo processo de conversão do coletivo em singular, fenômeno que exige um lugar cocriador do sujeito-ouvinte que se apropria dos significados expressos nas músicas e produz, a partir destes, novas zonas de sentido.

  19. Truncated RAP-MUSIC (TRAP-MUSIC) for MEG and EEG source localization.

    Science.gov (United States)

    Mäkelä, Niko; Stenroos, Matti; Sarvas, Jukka; Ilmoniemi, Risto J

    2018-02-15

    Electrically active brain regions can be located applying MUltiple SIgnal Classification (MUSIC) on magneto- or electroencephalographic (MEG; EEG) data. We introduce a new MUSIC method, called truncated recursively-applied-and-projected MUSIC (TRAP-MUSIC). It corrects a hidden deficiency of the conventional RAP-MUSIC algorithm, which prevents estimation of the true number of brain-signal sources accurately. The correction is done by applying a sequential dimension reduction to the signal-subspace projection. We show that TRAP-MUSIC significantly improves the performance of MUSIC-type localization; in particular, it successfully and robustly locates active brain regions and estimates their number. We compare TRAP-MUSIC and RAP-MUSIC in simulations with varying key parameters, e.g., signal-to-noise ratio, correlation between source time-courses, and initial estimate for the dimension of the signal space. In addition, we validate TRAP-MUSIC with measured MEG data. We suggest that with the proposed TRAP-MUSIC method, MUSIC-type localization could become more reliable and suitable for various online and offline MEG and EEG applications. Copyright © 2017 Elsevier Inc. All rights reserved.

  20. External radiation monitoring in TAPS and RAPS environs (1980-81) using TLD

    International Nuclear Information System (INIS)

    Basu, A.S.; Nambi, K.S.V.; Sunta, C.M.

    1983-01-01

    Results of environmental external radiation monitoring using quarterly integrated TLD measurements are presented for environments of the Tarapur Atomic Power Station (TAPS) and the Rajasthan Atomic Power Station (RAPS) for the two year monitoring period (1980-81). The data fit into the unimodal log-normal distribution except for locations where gaseous radioactivity escaping from the plant makes a significant contribution. The average natural radiation background in TAPS and RAPS environment is estimated to be 59.6 +- 4.7 mR yr -1 and 65.1 +- 9.8 mR yr -1 respectively. Contribution from the plant superimposed over the natural level leads frequently to bi-normal distribution. The effect of stack-released gaseous radioactivity is seen in locations within 1.6 km of TAPS: for example Ghivoli village registered an excess of 9.3 mR yr -1 over the natural background. The quarterly background values indicate minor temporal and spatial variations which can be attributed to changes in natural as well as stack released radioactivity. (author)

  1. Degrees of Intersectionality: Male Rap Artists in Sweden Negotiating Class, Race and Gender

    Directory of Open Access Journals (Sweden)

    Kalle Berggren

    2013-06-01

    Full Text Available “Intersectionality” has become a highly influential concept in gender research over the last 25 years. Debates have focused on differences and power asymmetries between women, in terms of race but also addressing class, age, sexuality, ability and nation. However, intersectional paradigms have been used to a much lesser extent in gender studies on men. This article seeks to contribute to an emerging discussion about intersectionality and masculinity by analyzing rap lyrics in Swe-dish songs. The data consists of a broad sample of rap lyrics by male artists 1991-2011, which is analyzed through poststructuralist discourse analysis and queer phenomenology. The analysis shows how classed discourses can be described in terms of orientation and flow, how racialization is articulated in terms of place, and the role of normative notions of gender and sexuality in anti-racist discourses. It is argued that this interconnectedness – class being related to race, which in turn is profoundly gendered – is neither well captured by the prevailing notion of “masculinities” in gender studies on men, nor by the “constitution” vs. “addition” dichotomy in intersectionality debates. Instead, it is suggested that degrees of in-tersectionality might be a more fruitful way of theorizing intersectionality in rela-tion to men.

  2. 15 CFR 700.81 - Appeals.

    Science.gov (United States)

    2010-01-01

    ... INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE NATIONAL SECURITY INDUSTRIAL BASE REGULATIONS DEFENSE... Economic Security under § 700.80, may appeal to the Assistant Secretary for Export Administration, U.S... Office of the Assistant Secretary for Export Administration, Bureau of Industry and Security, U.S...

  3. 6 CFR 27.345 - Appeals.

    Science.gov (United States)

    2010-01-01

    ... DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CHEMICAL FACILITY ANTI-TERRORISM STANDARDS Orders... appeal for appropriate matters. (d) Ex Parte Communications. (1) At no time after the filing of a Notice... decision on the matter, receives from or on behalf of any party, by means of an ex parte communication...

  4. 44 CFR 352.29 - Appeal process.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Appeal process. 352.29 Section 352.29 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY PREPAREDNESS COMMERCIAL NUCLEAR POWER PLANTS: EMERGENCY PREPAREDNESS PLANNING Federal...

  5. 7 CFR 1948.93 - Appeal procedure.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 13 2010-01-01 2009-01-01 true Appeal procedure. 1948.93 Section 1948.93 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... accordance with FmHA Instruction 1900-B. ...

  6. Appealing to Good Students in Introductory Economics.

    Science.gov (United States)

    Jensen, Elizabeth J.; Owen, Ann L.

    2003-01-01

    Examines effective teaching techniques using a unique data set that allows matching student and instructor characteristics to assess impact on student interest in economics. Finds devoting more time to discussion is effective but varies by type of student. Determines that a using many teaching techniques appeals to learning styles adopted by good…

  7. 8 CFR 1240.53 - Appeals.

    Science.gov (United States)

    2010-01-01

    ... Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION REGULATIONS PROCEEDINGS TO DETERMINE REMOVABILITY OF ALIENS IN THE UNITED STATES Proceedings To Determine Deportability of Aliens in the United States: Hearing and Appeal (for Proceedings Commenced Prior to April 1, 1997) § 1240...

  8. 12 CFR 403.8 - Appeals.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Appeals. 403.8 Section 403.8 Banks and Banking EXPORT-IMPORT BANK OF THE UNITED STATES CLASSIFICATION, DECLASSIFICATION, AND SAFEGUARDING OF NATIONAL... Vice President & Vice Chairman, Export-Import Bank of the United States, 811 Vermont Avenue NW...

  9. 33 CFR 135.405 - Appeal provisions.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Appeal provisions. 135.405 Section 135.405 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OFFSHORE OIL POLLUTION COMPENSATION FUND...

  10. 31 CFR 206.8 - Appeals.

    Science.gov (United States)

    2010-07-01

    ... Treasury, the Assistant Commissioner, Federal Finance, and the designated agency cash management official... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Appeals. 206.8 Section 206.8 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT...

  11. Teen Appeal — Touching the Moving Point

    Science.gov (United States)

    Handford, Christina

    An article to discuss the difficulties of designing educational multimedia for the teen target audience (13 - 16 year olds). The report will assess techniques used in existing online artefacts and reveal major trends in the attempt to appeal to this notoriously hard to reach user group.

  12. Effects of Persuasive Appeals in Public Service Advertising

    Science.gov (United States)

    Lynn, Jerry R.

    1974-01-01

    Concludes that of four message types perceived on the basis of persuasive appeal--emotional, logical, source-attribute, and fear--emotional appeal is the most effective and source-attribute the least effective method of advertising. (RB)

  13. Rock gabion, rip-rap, and culvert treatments: Successes and failures in post-fire erosion mitigation, Schultz Fire 2010

    Science.gov (United States)

    Daniel G. Neary; Karen A. Koestner

    2011-01-01

    Following the Schultz Fire in June of 2010, several erosion mitigation efforts were undertaken to reduce the impacts of post-fire flooding expected during the 2010 monsoon. One treatment consisted of the placement of large rock rip-rap on targeted fill slopes of a high elevation forest road that contains a buried pipeline supplying water to the city of Flagstaff....

  14. Open-Source Wax RepRap 3-D Printer for Rapid Prototyping Paper-Based Microfluidics.

    Science.gov (United States)

    Pearce, J M; Anzalone, N C; Heldt, C L

    2016-08-01

    The open-source release of self-replicating rapid prototypers (RepRaps) has created a rich opportunity for low-cost distributed digital fabrication of complex 3-D objects such as scientific equipment. For example, 3-D printable reactionware devices offer the opportunity to combine open hardware microfluidic handling with lab-on-a-chip reactionware to radically reduce costs and increase the number and complexity of microfluidic applications. To further drive down the cost while improving the performance of lab-on-a-chip paper-based microfluidic prototyping, this study reports on the development of a RepRap upgrade capable of converting a Prusa Mendel RepRap into a wax 3-D printer for paper-based microfluidic applications. An open-source hardware approach is used to demonstrate a 3-D printable upgrade for the 3-D printer, which combines a heated syringe pump with the RepRap/Arduino 3-D control. The bill of materials, designs, basic assembly, and use instructions are provided, along with a completely free and open-source software tool chain. The open-source hardware device described here accelerates the potential of the nascent field of electrochemical detection combined with paper-based microfluidics by dropping the marginal cost of prototyping to nearly zero while accelerating the turnover between paper-based microfluidic designs. © 2016 Society for Laboratory Automation and Screening.

  15. University-Community Collaboration to Promote Healthy Mothers and Infants: The Relationships and Parenting Support (RAPS) Program

    Science.gov (United States)

    Williams, Patricia Hrusa; Oravecz, Linda M.

    2016-01-01

    Research highlights the vulnerability of Black mothers and their infants, who experience higher rates of stress, preterm birth, low birth weight, and infant mortality than other racial groups. This article describes the development and implementation of the Relationships and Parenting Support (RAPS) Program, a community-based, family-focused…

  16. O negro drama do rap: entre a lei do cão e a lei da selva

    Directory of Open Access Journals (Sweden)

    Bruno Zeni

    2004-04-01

    Full Text Available NESTE texto são feitas algumas considerações que partem de interesses e preocupações pessoais do autor a respeito do rap, tais como a elaboração das letras, a relação entre essa manifestação e o universo da pobreza e da prisão, o diálogo do ritmo com a tradição da música e da literatura brasileiras. São discutidas ainda algumas das questões estéticas e éticas relacionadas ao rap feito em São Paulo.IN THIS text I set out some considerations that stem from keen personal interests and concerns regarding rap - e.g., the production of lyrics, the relationship between such manifestations and the universe of poverty and imprisonment, and the dialogue between this rhythm and the broader tradition of Brazilian music and literature. I discuss some aesthetic and ethical issues related to the variety of rap that I am most intimately involved with, namely, the one made in São Paulo.

  17. Are advertising appeal effective? Insights from a Meta- Analysis

    OpenAIRE

    J. Hornik; G. Miniero

    2011-01-01

    In this research we conduct a very comprehensive quantitative and qualitative literature review of 978 reports, to study: i) whether and by what size advertisements with appeals are more persuasive and better liked than ads with no appeals; ii) the various appeals in order to determine their relative effectiveness on two outcome variables: Persuasion and Aad (attitude toward the Ad). Results confirm that ads carrying appeals are significantly more persuasive and better liked than are ads w...

  18. PI3-kinase γ promotes Rap1a-mediated activation of myeloid cell integrin α4β1, leading to tumor inflammation and growth.

    Directory of Open Access Journals (Sweden)

    Michael C Schmid

    Full Text Available Tumor inflammation, the recruitment of myeloid lineage cells into the tumor microenvironment, promotes angiogenesis, immunosuppression and metastasis. CD11b+Gr1lo monocytic lineage cells and CD11b+Gr1hi granulocytic lineage cells are recruited from the circulation by tumor-derived chemoattractants, which stimulate PI3-kinase γ (PI3Kγ-mediated integrin α4 activation and extravasation. We show here that PI3Kγ activates PLCγ, leading to RasGrp/CalDAG-GEF-I&II mediated, Rap1a-dependent activation of integrin α4β1, extravasation of monocytes and granulocytes, and inflammation-associated tumor progression. Genetic depletion of PLCγ, CalDAG-GEFI or II, Rap1a, or the Rap1 effector RIAM was sufficient to prevent integrin α4 activation by chemoattractants or activated PI3Kγ (p110γCAAX, while activated Rap (RapV12 promoted constitutive integrin activation and cell adhesion that could only be blocked by inhibition of RIAM or integrin α4β1. Similar to blockade of PI3Kγ or integrin α4β1, blockade of Rap1a suppressed both the recruitment of monocytes and granulocytes to tumors and tumor progression. These results demonstrate critical roles for a PI3Kγ-Rap1a-dependent pathway in integrin activation during tumor inflammation and suggest novel avenues for cancer therapy.

  19. Appealing to fear: A Meta-Analysis of Fear Appeal Effectiveness and Theories

    Science.gov (United States)

    Tannenbaum, Melanie B.; Hepler, Justin; Zimmerman, Rick S.; Saul, Lindsey; Jacobs, Samantha; Wilson, Kristina; Albarracin, Dolores

    2018-01-01

    Fear appeals are a polarizing issue, with proponents confident in their efficacy and opponents confident that they backfire. We present the results of a comprehensive meta-analysis investigating fear appeals’ effectiveness for influencing attitudes, intentions, and behaviors. We tested predictions from a large number of theories, the majority of which have never been tested meta-analytically until now. Studies were included if they contained a treatment group exposed to a fear appeal, a valid comparison group, a manipulation of depicted fear, a measure of attitudes, intentions, or behaviors concerning the targeted risk or recommended solution, and adequate statistics to calculate effect sizes. The meta-analysis included 127 papers (9% unpublished) yielding 248 independent samples (NTotal = 27,372) collected from diverse populations. Results showed a positive effect of fear appeals on attitudes, intentions, and behaviors, with the average effect on a composite index being random-effects d¯ = 0.29. Moderation analyses based on prominent fear appeal theories showed that the effectiveness of fear appeals increased when the message included efficacy statements, depicted high susceptibility and severity, recommended one-time only (vs. repeated) behaviors, and targeted audiences that included a larger percentage of female message recipients. Overall, we conclude that (a) fear appeals are effective at positively influencing attitude, intentions, and behaviors, (b) there are very few circumstances under which they are not effective, and (c) there are no identified circumstances under which they backfire and lead to undesirable outcomes. PMID:26501228

  20. El rap español en el ámbito de los discursos de especialidad

    Directory of Open Access Journals (Sweden)

    Francisco Jiménez Calderón

    2012-11-01

    Full Text Available Normal 0 21 false false false ES X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} El presente artículo tiene como objetivo definir el rap español como un discurso de especialidad. Para ello, se revisa el concepto de ‘discurso de especialidad’, al que se alude con expresiones a menudo imprecisas como ‘lenguaje especial’, ‘lengua de especialidad’ o ‘jerga’. Ninguna, por distintas razones, parece adecuada; debe hablarse, en efecto, de ‘discurso de especialidad’, aunque una denominación como ‘discurso de actividad’ sería aún más precisa, pues nombraría el producto de comunicación que resulta de utilizar la lengua en un ámbito determinado, no necesariamente profesional, sino relativo a cualquier actividad concreta. Para situar al rap español en tal ámbito, se ha analizado un corpus de más de cien textos, que revela que, efectivamente, el rap presenta unos rasgos definitorios que le otorgan singularidad como discurso especial: terminología, desarrollo entre la escritura y la oralidad, reflexión metalingüística y acercamiento al género poético mediante el recurso a figuras retóricas consolidadas.

  1. 28 CFR 524.76 - Appeals of CIM classification.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Appeals of CIM classification. 524.76..., CLASSIFICATION, AND TRANSFER CLASSIFICATION OF INMATES Central Inmate Monitoring (CIM) System § 524.76 Appeals of CIM classification. An inmate may at any time appeal (through the Administrative Remedy Program) the...

  2. 32 CFR 701.109 - Privacy Act (PA) appeals.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Privacy Act (PA) appeals. 701.109 Section 701... OF THE NAVY DOCUMENTS AFFECTING THE PUBLIC DON Privacy Program § 701.109 Privacy Act (PA) appeals. (a... commence when the appeal reaches the office of the review authority having jurisdiction over the record...

  3. 5 CFR 511.613 - Appeals reconsideration by the Office.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Appeals reconsideration by the Office. 511.613 Section 511.613 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS CLASSIFICATION UNDER THE GENERAL SCHEDULE Classification Appeals § 511.613 Appeals reconsideration by the Office. The Office may, at its...

  4. 7 CFR 1900.56 - Non-appealable decisions.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false Non-appealable decisions. 1900.56 Section 1900.56 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS... REGULATIONS GENERAL Adverse Decisions and Administrative Appeals § 1900.56 Non-appealable decisions. The...

  5. 33 CFR 1.07-70 - Right to appeal.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Right to appeal. 1.07-70 Section 1.07-70 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY GENERAL GENERAL PROVISIONS Enforcement; Civil and Criminal Penalty Proceedings § 1.07-70 Right to appeal. (a) Any appeal from...

  6. 28 CFR 902.6 - Appeal to the Attorney General.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Appeal to the Attorney General. 902.6... ADJUDICATION PROCEDURES § 902.6 Appeal to the Attorney General. (a) The Federal Bureau of Investigation or a Compact Party State may appeal the decision of the Council to the U.S. Attorney General pursuant to...

  7. Buy, Buy, Buy. How to Recognize Advertising Appeals.

    Science.gov (United States)

    Dianna, Michael A.

    A compilation of activities and instructional ideas on advertising helps intermediate or junior high school teachers incorporate simple consumer education concepts into the social studies curriculum. Material is divided into three sections. An outline defines 16 advertising techniques including eye appeal, youth appeal, snob appeal, celebrity…

  8. An Instrument for the Systematic Study of Advertising Creative Appeals.

    Science.gov (United States)

    Secrist, Mark

    Although the generation of creative appeals is the heart and soul of advertising, there has been little methodology developed for the classification and study of the appeals themselves. The paper recommends the use of an instrument which provides a technique that will enable the advertising researcher to develop descriptive studies of ad appeals.…

  9. 43 CFR 4.410 - Who may appeal.

    Science.gov (United States)

    2010-10-01

    ... Bureau of Land Management or of an administrative law judge shall have a right to appeal to the Board... decisions of Bureau of Land Management officers must first be appealed to an administrative law judge under... of that decision, or has otherwise participated in the process leading to the decision under appeal...

  10. 49 CFR 31.39 - Appeal to authority head.

    Science.gov (United States)

    2010-10-01

    ... shall forward two copies of the notice of appeal to the authority head, and shall forward or make... 49 Transportation 1 2010-10-01 2010-10-01 false Appeal to authority head. 31.39 Section 31.39 Transportation Office of the Secretary of Transportation PROGRAM FRAUD CIVIL REMEDIES § 31.39 Appeal to authority...

  11. 13 CFR 134.702 - Who may appeal?

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Who may appeal? 134.702 Section 134.702 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING CASES BEFORE THE OFFICE OF HEARINGS AND APPEALS Rules of Practice for Appeals From Women-Owned Small...

  12. 10 CFR 13.41 - Stay pending appeal.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Stay pending appeal. 13.41 Section 13.41 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.41 Stay pending appeal. (a) An initial decision is stayed automatically pending disposition of a motion for reconsideration or of an appeal to the authority...

  13. 43 CFR 35.41 - Stay pending appeal.

    Science.gov (United States)

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Stay pending appeal. 35.41 Section 35.41... CLAIMS AND STATEMENTS § 35.41 Stay pending appeal. (a) An initial decision is stayed automatically pending disposition of a motion for reconsideration or of an appeal to the Secretary. (b) No...

  14. 38 CFR 42.41 - Stay pending appeal.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Stay pending appeal. 42...) STANDARDS IMPLEMENTING THE PROGRAM FRAUD CIVIL REMEDIES ACT § 42.41 Stay pending appeal. (a) An initial decision is stayed automatically pending disposition of a motion for reconsideration or of an appeal to the...

  15. 29 CFR 22.41 - Stay pending appeal.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Stay pending appeal. 22.41 Section 22.41 Labor Office of the Secretary of Labor PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 22.41 Stay pending appeal. (a) An initial decision is stayed automatically pending disposition of a motion for reconsideration or of an appeal to the...

  16. 31 CFR 16.41 - Stay pending appeal.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Stay pending appeal. 16.41 Section 16... PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 16.41 Stay pending appeal. (a) An initial decision is stayed automatically pending disposition of a motion for reconsideration or of an appeal to the authority head. (b) No...

  17. 14 CFR 1264.140 - Stay pending appeal.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Stay pending appeal. 1264.140 Section 1264... FRAUD CIVIL PENALTIES ACT OF 1986 § 1264.140 Stay pending appeal. (a) An initial decision is stayed automatically pending disposition of a motion for reconsideration or of an appeal to the authority head. (b) No...

  18. 20 CFR 355.41 - Stay pending appeal.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Stay pending appeal. 355.41 Section 355.41... REGULATIONS UNDER THE PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 355.41 Stay pending appeal. (a) An initial decision is stayed automatically pending disposition of a motion for reconsideration or of an appeal to the...

  19. 7 CFR 1.340 - Stay pending appeal.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Stay pending appeal. 1.340 Section 1.340 Agriculture... Hearings Under the Program Fraud Civil Remedies Act of 1986 § 1.340 Stay pending appeal. (a) A decision is stayed automatically pending disposition of a motion for reconsideration or of an appeal to the judicial...

  20. 12 CFR 404.17 - Appeal of denials of access.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Appeal of denials of access. 404.17 Section 404.17 Banks and Banking EXPORT-IMPORT BANK OF THE UNITED STATES INFORMATION DISCLOSURE Access to Records Under the Privacy Act of 1974 § 404.17 Appeal of denials of access. (a) Appeals to the Assistant General...

  1. 45 CFR 5.34 - Appeal of denials.

    Science.gov (United States)

    2010-10-01

    ... Release and Denial of Records § 5.34 Appeal of denials. (a) Right of appeal. You have the right to appeal... reasons why you believe that the FOIA exemption(s) we cited do not apply to the records that you requested... designated review official will consult with the General Counsel to ensure that the rights and interests of...

  2. 45 CFR 7.8 - Employee's right of appeal.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Employee's right of appeal. 7.8 Section 7.8 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION EMPLOYEE INVENTIONS § 7.8 Employee's right of appeal. An employee who is aggrieved by a determination of the Department may appeal to...

  3. 76 FR 6554 - Appeal Authority When Researcher Privileges Are Revoked

    Science.gov (United States)

    2011-02-07

    ..., aligning the two disciplinary appeal processes. Researchers retain their full right to appeal revocation... researchers' privileges under certain circumstances by following the procedures outlined in 36 CFR part 1254... NARA facility director; a process which is also described in 36 CFR part 1254. The current appeal...

  4. 8 CFR 1003.3 - Notice of appeal.

    Science.gov (United States)

    2010-01-01

    ... having administrative control over the record of proceeding within 30 days of the service of the decision...) General requirements for all appeals. The appeal must be accompanied by a check, money order, or fee... accompanied by a certified English translation. (b) Statement of the basis of appeal. The party taking the...

  5. 26 CFR 301.6326-1 - Administrative appeal of the erroneous filing of notice of federal tax lien.

    Science.gov (United States)

    2010-04-01

    ... tax lien. (a) In general. Any person may appeal to the district director of the district in which a notice of federal tax lien was filed on the property or rights to property of such person for a release... of notice of federal tax lien. 301.6326-1 Section 301.6326-1 Internal Revenue INTERNAL REVENUE...

  6. What makes icons appealing? The role of processing fluency in predicting icon appeal in different task contexts.

    OpenAIRE

    McDougall, S.; Reppa, I.; Kulik, J.; Taylor, A.

    2016-01-01

    Although icons appear on almost all interfaces, there is a paucity of research examining the determinants of icon appeal. The experiments reported here examined the icon characteristics determining appeal and the extent to which processing fluency - the subjective ease with which individuals process information - was used as a heuristic to guide appeal evaluations. Participants searched for, and identified, icons in displays. The initial appeal of icons was held constant while ease of process...

  7. Acoustic detection of particles, the RAP experiment: present status and results

    International Nuclear Information System (INIS)

    Bassan, M; Buonomo, B; Coccia, E; Blair, D; D'Antonio, S; Monache, G Delle; Gioacchino, D Di; Fafone, V; Ligi, C; Marini, A; Mazzitelli, G; Modestino, G; Pizzella, G; Quintieri, L; Roccella, S; Rocchi, A; Ronga, F; Tripodi, P; Valente, P

    2006-01-01

    Cosmic ray events with rate and energy much higher than expected were detected by the ultracryogenic gravitational antenna Nautilus located at the Laboratori Nazionali di Frascati, when it was operating in superconducting state. Mechanisms related to the superconductivity state of the material could be involved in such a way to enhance the conversion efficiency of the particle energy into vibrational energy of the detector. The RAP experiment has the aim to study the mechanical response of a small metallic resonant bar to short pulses of high energy electron beam, investigating the response of the bar both in normal and in superconducting state. The results obtained for an Al5056 bar down to a temperature of 4 K are reported and the preliminary results for a niobium bar at temperature below and above the superconducting-normal transition are also discussed

  8. Neural correlates of lyrical improvisation: an FMRI study of freestyle rap.

    Science.gov (United States)

    Liu, Siyuan; Chow, Ho Ming; Xu, Yisheng; Erkkinen, Michael G; Swett, Katherine E; Eagle, Michael W; Rizik-Baer, Daniel A; Braun, Allen R

    2012-01-01

    The neural correlates of creativity are poorly understood. Freestyle rap provides a unique opportunity to study spontaneous lyrical improvisation, a multidimensional form of creativity at the interface of music and language. Here we use functional magnetic resonance imaging to characterize this process. Task contrast analyses indicate that improvised performance is characterized by dissociated activity in medial and dorsolateral prefrontal cortices, providing a context in which stimulus-independent behaviors may unfold in the absence of conscious monitoring and volitional control. Connectivity analyses reveal widespread improvisation-related correlations between medial prefrontal, cingulate motor, perisylvian cortices and amygdala, suggesting the emergence of a network linking motivation, language, affect and movement. Lyrical improvisation appears to be characterized by altered relationships between regions coupling intention and action, in which conventional executive control may be bypassed and motor control directed by cingulate motor mechanisms. These functional reorganizations may facilitate the initial improvisatory phase of creative behavior.

  9. Neariminio žemės dirbimo poveikis vasarinių rapsų agroekosistemos komponentams

    OpenAIRE

    Petrauskas, Tomas

    2014-01-01

    Tikslas – įvertinti tiesioginės sėjos, supaprastinto žemės dirbimo ir augalinių liekanų įtaką kai kuriems vasarinių rapsų agroekosistemos komponentams. Stacionarus dviejų veiksnių lauko eksperimentas įrengtas 1999 m. Aleksandro Stulginskio universiteto Bandymų stotyje. A veiksnys − šiaudų panaudojimas: šiaudai pašalinti (-Š); šiaudai susmulkinti ir paskleisti (+Š). B veiksnys − žemės dirbimos sistemos: įprastas gilus arimas 23–25 cm gyliu rudenį (GA), kontrolinis variantas; seklus arimas 10–1...

  10. An ALARA approach to collective dose control at RAPS-3 and 4

    International Nuclear Information System (INIS)

    Khandelwal, Narendra; Dhakar, P.C.; Gupta, Ashok

    2016-01-01

    At Rajasthan Atomic Power Station-3 and 4 (RAPS 3 and 4) immense efforts were put to achieve continual reduction in man rem consumption in every subsequent year and this could be done successfully through implementing design changes based on experience, reducing radiation levels by removing radioactive material from undesired locations, flushing of active system/equipment's, shielding of hot spots, minimizing D20 leaks, manpower optimization, improvement in work culture and strong management commitment etc. Radiation protection is a never ending process and scope is always available to reduce the doses at all levels. Routine radiation survey sometimes does not provide exact idea about potential of significant collective exposure that can take place when ambient radiation levels are comparable to background radiation levels

  11. O rap e o funk na socialização da juventude

    Directory of Open Access Journals (Sweden)

    Dayrell Juarez

    2002-01-01

    Full Text Available O texto se propõe a discutir a importância dos grupos musicais juvenis nos processos de socialização vivenciados por jovens pobres na periferia de Belo Horizonte, problematizando o peso e o significado de ser membro de um grupo musical no conjunto da vida de cada um. Tem como foco os integrantes de três grupos de rap e três duplas de funk, procurando analisar as suas experiências culturais e o sentido que tais práticas adquirem no conjunto dos processos sociais que os constituem como sujeitos. Significa compreender como eles elaboram as suas vivências em torno do estilo, e os significados que atribuem a elas, no contexto social onde se inserem como jovens pobres. A discussão aponta que os jovens rappers e funkeiros encontram poucos espaços nas instituições do mundo adulto para construir referências e valores por meio dos quais possam se construir como sujeitos. Os estilos rap e funk assumem uma centralidade na vida desses jovens por intermédio das formas de sociabilidade que constroem, da música que criam, e dos eventos culturais que promovem. Esses estilos possibilitaram e vem possibilitando a esses jovens práticas, relações e símbolos por meio dos quais criam espaços próprios, significando uma referência na elaboração e vivência da sua condição juvenil, além de proporcionar a construção de uma auto-estima e identidades positivas.

  12. Rap-rimas afetivas da periferia: reflexões na perspectiva sócio-histórica Rap-affective rhymes of the periphery: reflections in the social-historical perspective

    Directory of Open Access Journals (Sweden)

    Jaison Hinkel

    2007-01-01

    Full Text Available Considerando a dimensão afetiva como constitutiva do agir e do pensar humano, e reconhecendo que sua presença é uma constante no Rap, este artigo busca investigar como a afetividade é expressa nas músicas de quatro grupos de Rap nacional. A partir da análise das músicas, pode-se considerar que estas expressam as vivências advindas de uma ordem social baseada na inclusão social perversa. Há instantes em que a tônica está no sentimento da vergonha, culpa, humilhação, tristeza, revolta e medo que assola os moradores da periferia. Em contrapartida, há propostas de enfrentamento desta condição, expressando a importância da união, irmandade, humildade, esperança, amor, alegria e solidariedade. Assim, nestas canções, a afetividade expressa tanto a denúncia do sofrimento ético-político, como a possibilidade de aumentar a potência de ação do sujeito para a superação da condição de padecimento humano, indicando a música, especialmente o Rap, como temática importante na compreensão psicossocial do sujeito em contextos de exclusão social.Considering the affectionate dimension as the constituent of act and of human thought, and recognizing that his presence is a constant one in the Rap, this article seeks to investigate like the affection is espress in the music of four groups of Rap national. Starting from the analysis of the music, we can consider that these express the resulting experiences of a social order based on the perverse social inclusion. There are instants in that to tonic is in the feeling of the shame, blame, humiliation, sorrow, revolt and fear that devastates the inhabitants of the periphery. In compensation, there is proposals to face of this condition, expressing the importance of the union, fraternity, humility, hope, love, joy and solidarity. Like this, in these songs, the so much express affection the denunciation of the ethical-political suffering, as the possibility of potency the action of the

  13. The celebrity appeal questionnaire: sex, entertainment, or leadership.

    Science.gov (United States)

    Stever, Gayle S

    2008-08-01

    The Celebrity Appeal Questionnaire was constructed to operationalize constructs related to why fans are attracted to their favorite celebrities and was developed for use with fan bases for specific celebrities. This revised version asked fans of a specific celebrity to rank order three roles they might see the target celebrity playing in society with an option to not rank them at all. Of 409 respondents attending Josh Groban fan club meetings, 75% said Groban's most important role in society was as a leader and role model in trying to make the world a better place. A factor analysis of correlations of Likert-type scale ratings and an analysis relating those factors back to the rank orderings support the internal reliability and validity of the questionnaire.

  14. An unusual internal ribosomal entry site of inverted symmetry directs expression of a potato leafroll polerovirus replication-associated protein

    Science.gov (United States)

    Jaag, Hannah Miriam; Kawchuk, Lawrence; Rohde, Wolfgang; Fischer, Rainer; Emans, Neil; Prüfer, Dirk

    2003-01-01

    Potato leafroll polerovirus (PLRV) genomic RNA acts as a polycistronic mRNA for the production of proteins P0, P1, and P2 translated from the 5′-proximal half of the genome. Within the P1 coding region we identified a 5-kDa replication-associated protein 1 (Rap1) essential for viral multiplication. An internal ribosome entry site (IRES) with unusual structure and location was identified that regulates Rap1 translation. Core structural elements for internal ribosome entry include a conserved AUG codon and a downstream GGAGAGAGAGG motif with inverted symmetry. Reporter gene expression in potato protoplasts confirmed the internal ribosome entry function. Unlike known IRES motifs, the PLRV IRES is located completely within the coding region of Rap1 at the center of the PLRV genome. PMID:12835413

  15. [Cloning of VH and VL Gene of Human anti-IL1RAP McAb and Construction of Recombinant Chimeric Receptor].

    Science.gov (United States)

    Yin, Ling-Ling; Ruan, Su-Hong; Tian, Yu; Zhao, Kai; Xu, Kai Lin

    2015-10-01

    To clone the variable region genes of human anti-IL1RAP (IL-1 receptor accessory protein) monoclonal antibodies (McAb) and to construct IL1RAP chimeric antigen receptors (CARs). The VH and VL DNA of IL1RAP single chain antibodies were amplified by RACE and overlap extension PCR from total RNA extracted from 3H6E10 and 10D8A7 hybridoma and ligated into specific IL1RAP single-chain variable fragments (scFv). CD8α transmembrane domain, CD137 intracellular domain, TCR ζ chain, human CD8α signal peptide and scFv-anti-IL1RAP were cloned into plasmid LV-lac. Recombinant lentiviruses were generated by co-transfection of recombinant plasmid LV-lac, pMD2. G, and psPAX2 helper vectors into 293FT packing cells. The VH and VL genes of 2 human anti-IL1RAP McAb were acquired. The 3H6E10 VH and VL genes consisted of 402 bp and 393 bp encoding 134 and 131 aminoacid residues, respectively; 10D8A7 VH and VL genes consisted of 423 bp and 381 bp encoding 141 and 127 amine acid residues, respectively. Recombinant expression vertors LV-3H6E10 scFv-ICD and LV-10D8A7 scFv-ICD (ICD: CD8α transmembrane domain-CD137 intracellular domain-TCR ζ chain) were constructed. The target fragments were demonstrated by sequencing analysis. Recombinant plasmids were transfected into 293FT cells and lentiviral particles were acquired. Human anti-IL1RAP recombinant receptors are constructed successfully and lay a good foundation for the construction of IL1RAP-CAR killer T cell vaccine.

  16. Efficient transcription of the glycolytic gene ADH1 and three translational component genes requires the GCR1 product, which can act through TUF/GRF/RAP binding sites.

    OpenAIRE

    Santangelo, G M; Tornow, J

    1990-01-01

    Glycolytic gene expression in Saccharomyces cerevisiae is thought to be activated by the GCR and TUF proteins. We tested the hypothesis that GCR function is mediated by TUF/GRF/RAP binding sites (UASRPG elements). We found that UASRPG-dependent activation of a heterologous gene and transcription of ADH1, TEF1, TEF2, and RP59 were sensitive to GCR1 disruption. GCR is not required for TUF/GRF/RAP expression or in vitro DNA-binding activity.

  17. International

    International Nuclear Information System (INIS)

    Anon.

    1997-01-01

    This rubric reports on 10 short notes about international economical facts about nuclear power: Electricite de France (EdF) and its assistance and management contracts with Eastern Europe countries (Poland, Hungary, Bulgaria); Transnuclear Inc. company (a 100% Cogema daughter company) acquired the US Vectra Technologies company; the construction of the Khumo nuclear power plant in Northern Korea plays in favour of the reconciliation between Northern and Southern Korea; the delivery of two VVER 1000 Russian reactors to China; the enforcement of the cooperation agreement between Euratom and Argentina; Japan requested for the financing of a Russian fast breeder reactor; Russia has planned to sell a floating barge-type nuclear power plant to Indonesia; the control of the Swedish reactor vessels of Sydkraft AB company committed to Tractebel (Belgium); the renewal of the nuclear cooperation agreement between Swiss and USA; the call for bids from the Turkish TEAS electric power company for the building of the Akkuyu nuclear power plant answered by three candidates: Atomic Energy of Canada Limited (AECL), Westinghouse (US) and the French-German NPI company. (J.S.)

  18. RAPS. A threedimensional plotprogram for testing of the model and for plotting of the results of finite-element calculations

    International Nuclear Information System (INIS)

    Koschmieder, D.; Altes, J.

    1979-06-01

    Usually in Finite-Element calculations a large amount of data is produced and because individual results have no meaning, graphic representation is bestsuited. It is convenient to link the F E Software-System with pre- and postprocessors. The plotting system RAPS, presented on the following pages, offers many possibilities for testing and description of two- or threedimensional structures, as well as for interpretation of results of static and dynamic calculations. The programm was developed for the F E System ASKA but it is possible to fit it to other F E Systems. At present the program is laid out for batchoperation. However it is planned to develop an interactive version of RAPS and to enlarge the postprocessor. (orig.) [de

  19. A demonstration of the applicability of implementing the enhanced Remedial Action Priority System (RAPS) for environmental releases

    Energy Technology Data Exchange (ETDEWEB)

    Whelan, G.; Droppo, J.G. Jr.; Strenge, D.L.; Walter, M.B.; Buck, J.W.

    1989-12-01

    The Remedial Action Priority System (RAPS) and the Multimedia Environmental Pollutant Assessment System (MEPAS) were developed to prioritize problems associated with potential releases of hazardous chemical and radioactive materials in a scientific and objective manner based on limited site information. This report documents the model testing efforts of the RAPS/MEPAS methodology for the atmospheric, surface water, groundwater, and exposure components. Comparisons are given of model outputs with measured data at three sites: the US Department of Energy's Mound facility in Ohio and Hanford facility in Washington, and a chromium-cadmium plating site in New York. The results show that the simulated magnitudes, spacial and temporal trends, and distributions of contaminants corresponded well with the measured data. 25 refs., 86 figs., 26 tabs.

  20. PlexinA2 Forward Signaling through Rap1 GTPases Regulates Dentate Gyrus Development and Schizophrenia-like Behaviors

    Directory of Open Access Journals (Sweden)

    Xiao-Feng Zhao

    2018-01-01

    Full Text Available Summary: Dentate gyrus (DG development requires specification of granule cell (GC progenitors in the hippocampal neuroepithelium, as well as their proliferation and migration into the primordial DG. We identify the Plexin family members Plxna2 and Plxna4 as important regulators of DG development. Distribution of immature GCs is regulated by Sema5A signaling through PlxnA2 and requires a functional PlxnA2 GTPase-activating protein (GAP domain and Rap1 small GTPases. In adult Plxna2−/− but not Plxna2-GAP-deficient mice, the dentate GC layer is severely malformed, neurogenesis is compromised, and mossy fibers form aberrant synaptic boutons within CA3. Behavioral studies with Plxna2−/− mice revealed deficits in associative learning, sociability, and sensorimotor gating—traits commonly observed in neuropsychiatric disorder. Remarkably, while morphological defects are minimal in Plxna2-GAP-deficient brains, defects in fear memory and sensorimotor gating persist. Since allelic variants of human PLXNA2 and RAP1 associate with schizophrenia, our studies identify a biochemical pathway important for brain development and mental health. : Zhao et al. find that Sema5A-PlexinA2 forward signaling through Rap1 GTPases is required for progenitor distribution in the developing mouse dentate gyrus. Adult Plxna2−/−, but not Plxna2-GAP-deficient, mice show defects in dentate morphology, neurogenesis, and mossy fiber connectivity. Plxna2−/− and Plxna2-GAP mice exhibit behavioral defects suggestive of neuropsychiatric illness. Keywords: PlexinA2, semaphoring, Rap1, GAP, dentate gyrus, adult neurogenesis, mossy fiber, fear memory, sensorimotor gating, schizophrenia

  1. Cell motility in chronic lymphocytic leukemia: defective Rap1 and alphaLbeta2 activation by chemokine.

    Science.gov (United States)

    Till, Kathleen J; Harris, Robert J; Linford, Andrea; Spiller, David G; Zuzel, Mirko; Cawley, John C

    2008-10-15

    Chemokine-induced activation of alpha4beta1 and alphaLbeta2 integrins (by conformational change and clustering) is required for lymphocyte transendothelial migration (TEM) and entry into lymph nodes. We have previously reported that chemokine-induced TEM is defective in chronic lymphocytic leukemia (CLL) and that this defect is a result of failure of the chemokine to induce polar clustering of alphaLbeta2; engagement of alpha4beta1 and autocrine vascular endothelial growth factor (VEGF) restore clustering and TEM. The aim of the present study was to characterize the nature of this defect in alphaLbeta2 activation and determine how it is corrected. We show here that the alphaLbeta2 of CLL cells is already in variably activated conformations, which are not further altered by chemokine treatment. Importantly, such treatment usually does not cause an increase in the GTP-loading of Rap1, a GTPase central to chemokine-induced activation of integrins. Furthermore, we show that this defect in Rap1 GTP-loading is at the level of the GTPase and is corrected in CLL cells cultured in the absence of exogenous stimuli, suggesting that the defect is the result of in vivo stimulation. Finally, we show that, because Rap1-induced activation of both alpha4beta1 and alphaLbeta2 is defective, autocrine VEGF and chemokine are necessary to activate alpha4beta1 for ligand binding. Subsequently, this binding and both VEGF and chemokine stimulation are all needed for alphaLbeta2 activation for motility and TEM. The present study not only clarifies the nature of the alphaLbeta2 defect of CLL cells but is the first to implicate activation of Rap1 in the pathophysiology of CLL.

  2. Vitek 2 ANC card versus BBL Crystal Anaerobe and RapID ANA II for identification of clinical anaerobic bacteria.

    Science.gov (United States)

    Blairon, Laurent; Maza, Mengi L; Wybo, Ingrid; Piérard, Denis; Dediste, Anne; Vandenberg, Olivier

    2010-08-01

    The Vitek 2 Anaerobe and Corynebacterium Identification Card (ANC) was recently evaluated in a multicentre study. In the present work, this system was compared with the BBL Crystal Anaerobe and RapID ANA II panels. These kits were tested using 196 strains of anaerobes that had been previously identified by gas-liquid chromatography. Identification to the species or to the genus level was 75.0%, 81.1% and 70.9% for Crystal, RapID and Vitek, respectively. Vitek ANC failed to provide any identification in 20.4% of the strains, but it had fewer misidentifications than RapID. The confidence factors provided on the results report of each kit were not always correlated with a lower risk of major errors, with the exception of Vitek 2 in which a confidence factor higher than 0.86 excluded the risk of misidentification in more than 87% of isolates. The lower rate of identification by the Vitek and Crystal panels is mostly due the lower ability of these systems to identify the Clostridia. Overall, the three panels are comparable but need improvement to a better accuracy. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

  3. Microgravity simulation activates Cdc42 via Rap1GDS1 to promote vascular branch morphogenesis during vasculogenesis

    Directory of Open Access Journals (Sweden)

    Shouli Wang

    2017-12-01

    Full Text Available Gravity plays an important role in normal tissue maintenance. The ability of stem cells to repair tissue loss in space through regeneration and differentiation remains largely unknown. To investigate the impact of microgravity on blood vessel formation from pluripotent stem cells, we employed the embryoid body (EB model for vasculogenesis and simulated microgravity by clinorotation. We first differentiated mouse embryonic stem cells into cystic EBs containing two germ layers and then analyzed vessel formation under clinorotation. We observed that endothelial cell differentiation was slightly reduced under clinorotation, whereas vascular branch morphogenesis was markedly enhanced. EB-derived endothelial cells migrated faster, displayed multiple cellular processes, and had higher Cdc42 and Rac1 activity when subjected to clinorotation. Genetic analysis and rescue experiments demonstrated that Cdc42 but not Rac1 is required for microgravity-induced vascular branch morphogenesis. Furthermore, affinity pull-down assay and mass spectrometry identified Rap1GDS1 to be a Cdc42 guanine nucleotide exchange factor, which was upregulated by clinorotation. shRNA-mediated knockdown of Rap1GDS1 selectively suppressed Cdc42 activation and inhibited both baseline and microgravity-induced vasculogenesis. This was rescued by ectopic expression of constitutively active Cdc42. Taken together, these results support the notion that simulated microgravity activates Cdc42 via Rap1GDS1 to promote vascular branch morphogenesis.

  4. GCR1, a transcriptional activator in Saccharomyces cerevisiae, complexes with RAP1 and can function without its DNA binding domain.

    Science.gov (United States)

    Tornow, J; Zeng, X; Gao, W; Santangelo, G M

    1993-01-01

    In Saccharomyces cerevisiae, efficient expression of glycolytic and translational component genes requires two DNA binding proteins, RAP1 (which binds to UASRPG) and GCR1 (which binds to the CT box). We generated deletions in GCR1 to test the validity of several different models for GCR1 function. We report here that the C-terminal half of GCR1, which includes the domain required for DNA binding to the CT box in vitro, can be removed without affecting GCR1-dependent transcription of either the glycolytic gene ADH1 or the translational component genes TEF1 and TEF2. We have also identified an activation domain within a segment of the GCR1 protein (the N-terminal third) that is essential for in vivo function. RAP1 and GCR1 can be co-immunoprecipitated from whole cell extracts, suggesting that they form a complex in vivo. The data are most consistent with a model in which GCR1 is attracted to DNA through contact with RAP1. Images PMID:8508768

  5. ChemWaste appeals Hanford permit stance

    International Nuclear Information System (INIS)

    Anon.

    1993-01-01

    Chemical Waste Management, Inc. is appealing the Washington State Department of Ecology's decision to suspend its review of the company's proposal to build a hazardous waste incinerator and two mixed waste incinerators at the Hanford Nuclear Site near Richland, Washington. The company wants to build the incinerators on a 200 acre parcel in the DOE reservation that is leased to the State. The State contends the two mixed waste incinerators meet siting criteria, but the hazardous waste unit does not. A compromise may be reached between DOE and Washington state involving the transfer of title to the leased land from DOE to the State

  6. Canada loses appeal of WTO panel ruling on minimum patent terms.

    Science.gov (United States)

    Elliott, R

    2000-01-01

    In the last issue, we reported on a ruling of a Panel of the World Trade Organization (WTO) that Canada was in breach of the international Agreement on Trade-Related Aspects of Intellectual Property Rights (the TRIPS Agreement). The Panel found that Canada's Patent Act does not provide the minimum patent terms required by the trade agreement. Canada appealed that decision, but on 18 September 2000 the WTO Appellate Body upheld the Panel ruling.

  7. Diaspora portoricaine et musique rap à New-York : entre latinité et culture africaine américaine Puerto Rican diaspora and rap music in New-York city: between “latininad” and African American culture

    Directory of Open Access Journals (Sweden)

    Stéphane Partel

    2012-05-01

    Full Text Available Le rap a atteint un succès sans précédent auprès des jeunes urbains aux Etats-Unis et dans les grandes mégalopoles du monde entier. Ce genre musical, figure de proue du hip-hop, s’est affirmé dès les années 1970 comme un moyen d’expression diasporique reflétant les expériences, les rapports complexes et les interactions culturelles entre Africains Américains, Jamaïcains et Portoricains de la diaspora vivant à New York. Cependant, le positionnement des artistes issus de la diaspora portoricaine a été peu étudié. Nourri de séjours d’observation participante et de recherches réalisés entre 2005 et 2008, ainsi que de la fréquentation assidue des concerts du collectif artistique portoricain The Terror Squad auxquels l’auteur a pu assister, cet article se propose doncd’analyser le rôle central des artistes issus de la diaspora portoricaine de New York à travers l’étude du rap, élément le plus médiatisé du hip-hop. Il devient ainsi possible de mieux entrevoir les tensions, convergences et interactions culturelles qui régissent les rapports complexes qui s’établissent entre la latinité des Portoricains et la culture africaine-américaine urbaine depuis plus d’une trentaine d’années dans le milieu du rap.Rap music has achieved unprecedented success among urban youth in the United States and in big cities around the world. As a key element of hip-hop this musical style has been asserting its strength since the 1970s as a reflection of the diasporic experience and the complex cultural interactions between African Americans, Jamaicans and Puerto Ricans of the diaspora living in New York. However, scant research has been conducted on the role of Puerto Rican artists of the diaspora living in New York. Therefore, based on field trips and participant observation undertaken between 2005 and 2008 and the concerts of the Puerto Rican rap group The Terror Squad that the author was able to attend frequently, the

  8. Genetic diversity and natural selection in the rhoptry-associated protein 1 (RAP-1) of recent Plasmodium knowlesi clinical isolates from Malaysia.

    Science.gov (United States)

    Rawa, Mira Syahfriena Amir; Fong, Mun-Yik; Lau, Yee-Ling

    2016-02-05

    The Plasmodium rhoptry-associated protein 1 (RAP-1) plays a role in the formation of the parasitophorous vacuole following the parasite's invasion of red blood cells. Although there is some evidence that the protein is recognized by the host's immune system, study of Plasmodium falciparum RAP-1 (PfRAP-1) suggests that it is not under immune pressure. A previous study on five old (1953-1962) P. knowlesi strains suggested that RAP-1 has limited genetic polymorphism and might be under negative selection. In the present study, 30 recent P. knowlesi isolates were studied to obtain a better insight into the polymorphism and natural selection of PkRAP-1. Blood samples from 30 knowlesi malaria patients were used. These samples were collected between 2010 and 2014. The PkRAP-1 gene, which contains two exons, was amplified by PCR, cloned into Escherichia coli and sequenced. Genetic diversity and phylogenetic analyses were performed using MEGA6 and DnaSP ver. 5.10.00 programs. Thirty PkRAP-1 sequences were obtained. The nucleotide diversity (π) of exons 1, 2 and the total coding region (0.00915, 0.01353 and 0.01298, respectively) were higher than those of the old strains. Further analysis revealed a lower rate of non-synonymous (dN) than synonymous (dS) mutations, suggesting negative (purifying) selection of PkRAP-1. Tajima's D test and Fu and Li's D test values were not significant. At the amino acid level, 22 haplotypes were established with haplotype H7 having the highest frequency (7/34, 20.5 %). In the phylogenetic analysis, two distinct haplotype groups were observed. The first group contained the majority of the haplotypes, whereas the second had fewer haplotypes. The present study found higher genetic polymorphism in the PkRAP-1 gene than the polymorphism level reported in a previous study. This observation may stem from the difference in sample size between the present (n = 30) and the previous (n = 5) study. Synonymous and non-synonymous mutation analysis indicated

  9. RAP2.4a Is Transported through the Phloem to Regulate Cold and Heat Tolerance in Papaya Tree (Carica papaya cv. Maradol: Implications for Protection Against Abiotic Stress.

    Directory of Open Access Journals (Sweden)

    Luis Figueroa-Yañez

    Full Text Available Plants respond to stress through metabolic and morphological changes that increase their ability to survive and grow. To this end, several transcription factor families are responsible for transmitting the signals that are required for these changes. Here, we studied the transcription factor superfamily AP2/ERF, particularly, RAP2.4 from Carica papaya cv. Maradol. We isolated four genes (CpRap2.4a, CpRAap2.4b, CpRap2.1 and CpRap2.10, and an in silico analysis showed that the four genes encode proteins that contain a conserved APETALA2 (AP2 domain located within group I and II transcription factors of the AP2/ERF superfamily. Semiquantitative PCR experiments indicated that each CpRap2 gene is differentially expressed under stress conditions, such as extreme temperatures. Moreover, genetic transformants of tobacco plants overexpressing CpRap2.4a and CpRap2.4b genes show a high level of tolerance to cold and heat stress compared to non-transformed plants. Confocal microscopy analysis of tobacco transgenic plants showed that CpRAP2.4a and CpRAP2.4b proteins were mainly localized to the nuclei of cells from the leaves and roots and also in the sieve elements. Moreover, the movement of CpRap2.4a RNA in tobacco grafting was analyzed. Our results indicate that CpRap2.4a and CpRap2.4b RNA in the papaya tree have a functional role in the response to stress conditions such as exposure to extreme temperatures via direct translation outside the parental RNA cell.

  10. Relationships between the Advertising Appeal and Behavioral Intention: The Mediating role of the Attitude towards Advertising Appeal

    Directory of Open Access Journals (Sweden)

    Raza Syed Hassan

    2017-01-01

    Full Text Available The link between the advertising appeal, attitude and behavioral intention is dynamic in nature, however, little research has been pursued towards explaining the mediating role of attitude towards the advertising in link of the advertising appeal with the behavioral intention. Researchers have identified the importance of the attitude in the connection of the advertising appeal within the framework of the (TPB which remains unaddressed in the explicating the mediation of the attitude in relationship of advertising appeal and behavioral intention. This paper aims to provide insight of the attitude towards the advertising as the mediating factor in explaining the relationship between the advertising appeal and behavioral intention. In addition, this paper is only a theoretical exploration, it is expected that this work lead towards an explanation of the mediating role of the attitude to address the relation of advertising appeal and intention which may be studied further to determine the empirical finding about the other dynamic of the (TPB.

  11. Polymorphisms of ST2-IL18R1-IL18RAP gene cluster: a new risk for autoimmune thyroid diseases.

    Science.gov (United States)

    Wang, X; Zhu, Y F; Li, D M; Qin, Q; Wang, Q; Muhali, F S; Jiang, W J; Zhang, J A

    2016-02-01

    Interleukin 33 (IL33) / ST2 pathway and ST2-interlukin18 receptor1-interlukin18 receptor accessory protein (ST2-IL18R1-IL18RAP) gene cluster have been involved in many autoimmune diseases but few report in autoimmune thyroid diseases (AITD). In this study, we investigated whether polymorphisms of IL33, ST2, IL18R1, and IL18RAP are associated with Graves' disease (GD) and Hashimoto's thyroiditis (HT), two major forms of AITD, among a Chinese population. A total of 11 SNPs were explored in a case-control study including 417 patients with GD, 250 HT patients and 301 controls, including rs1929992, rs10975519, rs10208293, rs6543116, rs1041973, rs3732127, rs11465597, rs1035130, rs2293225, rs1035127, rs917997 of IL 33, ST2-IL18R1-IL18RAP gene cluster. Genotyping of these SNPs was performed using matrix-assisted laser desorption / ionization-time-of-flight mass spectrometer (MALDI-TOF-MS) platform from Sequenom. The frequencies of allele A and AA+AG genotype of rs6543116 (ST2) in HT patients were significantly increased compared with those of the controls (P = 0.029/0.021, OR = 1.31/1.62). And in another SNP rs917997, AA+AG genotype presented an increased frequency in HT subjects compared with controls (P = 0.046, OR = 1.53). Furthermore, the haplotype GAGCCCG from ST2-IL18R1-IL18RAP gene cluster (rs6543116, rs1041973, rs1035130, rs3732127, rs1035127, rs2293225, rs917997) was associated with increased susceptibility to GD with an OR of 2.03 (P = 0.022, 95% CI = 1.07-3.86). Some SNPs of ST2-IL18R1-IL18RAP gene cluster might increase the risk of susceptibility of HT and GD in Chinese Han population. © 2015 John Wiley & Sons Ltd.

  12. Disambiguating authenticity: Interpretations of value and appeal.

    Directory of Open Access Journals (Sweden)

    Kieran O'Connor

    Full Text Available While shaping aesthetic judgment and choice, socially constructed authenticity takes on some very different meanings among observers, consumers, producers and critics. Using a theoretical framework positing four distinct meanings of socially constructed authenticity-type, moral, craft, and idiosyncratic-we aim to document empirically the unique appeal of each type. We develop predictions about the relationships between attributed authenticity and corresponding increases in the value ascribed to it through: (1 consumer value ratings, (2 willingness to pay, and (3 behavioral choice. We report empirical analyses from a research program of three multi-method studies using (1 archival data from voluntary consumer evaluations of restaurants in an online review system, (2 a university-based behavioral lab experiment, and (3 an online survey-based experiment. Evidence is consistent across the studies and suggests that perceptions of four distinct subtypes of socially constructed authenticity generate increased appeal and value even after controlling for option quality. Findings suggest additional directions for research on authenticity.

  13. Appeals court reverses verdict favoring drug companies.

    Science.gov (United States)

    1995-06-02

    An appeals court reversed a verdict favoring drug companies after the widow of a hemophiliac, whose death was linked to HIV-tainted blood products, sued four pharmaceutical companies to pay damages. The four companies, Alpha Therapeutic Corp., Miles Laboratories Inc., Armour Pharmaceutical Co., and Baxter Travenol Laboratories Inc., provided Factor VIII, a clotting concentrate, to [name removed] [name removed], the plaintiff's husband, from 1972 until his death in 1987. [Name removed]'s wife sued the companies, alleging that the defendants negligently solicited blood plasma from paid donors who had a high risk of having HIV, failed to determine whether any lots of Factor VIII contained plasma from an at-risk donor, failed to warn consumers of possible risks, and failed to heat-treat HIV and other viruses in Factor VIII, despite industry-wide knowledge of the risk of infection. The three-judge panel said the trial judge's decision to avoid ruling on the antigenic stimulation theory, based on insufficient evidence, was improper. In addition, the appeals court said a retrial is necessary because of improper remarks made by Alpha's attorney.

  14. Ecological risk assessment of RAPS waste water disposal in RPS Lake

    International Nuclear Information System (INIS)

    Verma, P.C.; Hegde, A.G.; Sharma, L.L.; Venkatramani, B.

    2007-01-01

    The ecological risk assessment is important tool in predicting the likelihood of future adverse effects from a given facility. Ecological risk assessment in itself has several features that contribute to effective environmental decision making for supporting the management actions. This paper attempts to asses the ecological risk evaluated on the basis of thermal ecological studies carried out at Rana Pratap Sagar (RPS) lake during 2002-2005. The study includes monitoring of several water quality parameters, biological and bacterial parameters and data on thermal stratification in respect of RPS reservoir. The monitored data on water quality were subjected to statistical analysis to evaluate the risk. Using fuzzy synthetic evaluation system on the basis of water quality guidelines from WHO, BIS and ICMR with combination of expert perception the water quality belongs to desirable category during all the seasons through out the year. The study reveals that there is no adverse effect on RPS water quality due to release of warmed effluents from Rajasthan Atomic Power Station (RAPS). Moreover, it shows that RPS water is nearly homogeneous and shows weak thermocline and chemocline patterns. Based on monitoring data, the reservoir can be assigned mild eutrophic status. (author)

  15. Mechanical performance assessment of half warm recycled asphalt mixes containing up to 100 % RAP

    International Nuclear Information System (INIS)

    Lizárraga, J. M.; Jiménez del Barco-Carrión, A.; Ramírez, A.; Díaz, P.; Moreno-Navarro, F.; Rubio, M.C.

    2017-01-01

    The use of Half Warm Mixes with high Reclaimed Asphalt content (HWMRA) has the potential to generate significant environmental advantages such as the reduction in consumption of natural resources and the emission of gases into the atmosphere. This paper therefore focuses on demonstrating the viability of using these types of mixes in wearing courses. For this purpose, an HWMRA with 70 % and 100 % Reclaimed Asphalt Pavement (RAP) and emulsion were designed in the laboratory. The performance of the mixes was then assessed and compared with that of conventional Hot Mix Asphalt. In a second stage, the mixes were manufactured in-plant, and laid and compacted in an Accelerated Pavement Test track. The cores were then extracted and tested for stiffness modulus and resistance to fatigue. The results from the tests conducted with both the laboratory specimens and the cores showed that the performance of HWMRA is comparable to that of HMA. These findings encourage greater confidence in promoting the use of these types of sustainable asphalt mixes. [es

  16. Mechanical performance assessment of half warm recycled asphalt mixes containing up to 100 % RAP

    Directory of Open Access Journals (Sweden)

    J. M. Lizárraga

    2017-07-01

    Full Text Available The use of Half Warm Mixes with high Reclaimed Asphalt content (HWMRA has the potential to generate significant environmental advantages such as the reduction in consumption of natural resources and the emission of gases into the atmosphere. This paper therefore focuses on demonstrating the viability of using these types of mixes in wearing courses. For this purpose, an HWMRA with 70 % and 100 % Reclaimed Asphalt Pavement (RAP and emulsion were designed in the laboratory. The performance of the mixes was then assessed and compared with that of conventional Hot Mix Asphalt. In a second stage, the mixes were manufactured in-plant, and laid and compacted in an Accelerated Pavement Test track. The cores were then extracted and tested for stiffness modulus and resistance to fatigue. The results from the tests conducted with both the laboratory specimens and the cores showed that the performance of HWMRA is comparable to that of HMA. These findings encourage greater confidence in promoting the use of these types of sustainable asphalt mixes.

  17. Using rap music to promote adolescent health: pilot study of VoxBox.

    Science.gov (United States)

    Paukste, Ernesta; Harris, Neil

    2015-04-01

    Alcohol, tobacco and other drugs (ATODs) usage among adolescents, particularly those living in lower socioeconomic communities, is a population health problem in Australia that requires innovative health promotion strategies. There is a growing recognition of the potential of arts-based approaches to engage youth in health promoting activities. This paper presents the process evaluation of the pilot VoxBox intervention that used rap to build adolescents' awareness of risks associated with ATODs. The VoxBox intervention was piloted in Logan, Queensland, at five high schools with 18 adolescents completing the intervention. Data collection methods included observation, focus groups, semi-structured interviews and a survey of adolescent participants. The intervention was well received by participants and stakeholders. Three factors characterising the project's successful engagement of adolescents were: participate - go with the flow, learning from the real deal and resourced to make some noise. In VoxBox, the emphasis on engaging adolescents in an activity of real interest that was appropriately resourced and delivered was central to credibility and success. SO WHAT?: The findings highlight the importance of interventions matching the interests of the targeted population group.

  18. Medical surveillance of occupational Noise Induced Hearing Loss (NIHL) at RAPS hospital

    International Nuclear Information System (INIS)

    Manuwal, A.K.; Ganesan, S.

    2009-01-01

    Full text: One of the most challenging roles of a Certifying Surgeon is to act as catalyst for change. This paper is a presentation of the impact of such an effort. Noise is the insidious of all industrial pollutants, involving every industry and causing severe hearing loss. Exposure to excessive noise is the major avoidable cause of permanent hearing impairment. Noise - induced hearing loss (NIHL) is bilateral and symmetrical, usually affecting the higher frequencies 3 k, 4 k or 6 kHz ) and then spreading to the lower frequencies (0.5 k,1 k or 2 kHz). The major health effects are lack of concentration, irritation, fatigue, headache, sleep disturbances etc. Hearing protectors should be used when engineering controls and work practices are not feasible for reducing noise exposure to safe levels. Ear muffs, ear plugs and ear canal caps are the main types of hearing protectors. Awareness should be created among workers about the harmful effects of noise on hearing and other body systems by implementing compulsory education noise conservation programmes. The practice followed at RAPS Hospital for medical surveillance of Occupational Noise Induced Hearing Loss is being briefed

  19. Comparison of dilute chemical decontaminations of RAPS-2 full primary heat transport system

    International Nuclear Information System (INIS)

    Bhat, H.R.

    2000-01-01

    First ever attempt to decontaminate a full primary system of an Indian PHWR was carried out at Rajasthan Atomic Power Station Unit -2 (RAPS-2) in August 1992. The decontamination factors obtained were moderate. The second attempt to decontaminate the same system was made in February 1996 with a different formulation. The decontamination factors obtained were lesser than the earlier attempt. The details of the two campaigns and their relative merits and demerits are discussed. Some more studies are required to be done before further implementation of the picolonic acid/ascorbic acid formulation. The 1992 attempt was with picolinic acid and ascorbic acid whereas the 1996 attempt was with EDTA + citric acid + ascorbic Acid (EAC ) formulation. A number of lessons were learnt from the first campaign and the improvements were applied during the subsequent decontamination campaigns at Madras Atomic Power station. The total iron removed and various radio nuclides removed are also detailed in the paper. Picolonic acid and ascorbic acid is a better formulation for decontamination of full PHT systems of Indian PHWRs. Use of EAC formulation generates a lot of crud which settles in narrow clearances. Picolonic Acid/Ascorbic Acid formulation does not generate any crud. Decontamination using a single cycle of the picolonic acid/ascorbic acid formulation is more effective than the decontamination using three cycles of EAC formulation. (author)

  20. Relationships between the Advertising Appeal and Behavioral Intention: The Mediating role of the Attitude towards Advertising Appeal

    OpenAIRE

    Raza Syed Hassan; Abu Bakar Hassan; Mohamad Bahtiar

    2017-01-01

    The link between the advertising appeal, attitude and behavioral intention is dynamic in nature, however, little research has been pursued towards explaining the mediating role of attitude towards the advertising in link of the advertising appeal with the behavioral intention. Researchers have identified the importance of the attitude in the connection of the advertising appeal within the framework of the (TPB) which remains unaddressed in the explicating the mediation of the attitude in rela...

  1. miR-518b Enhances Human Trophoblast Cell Proliferation Through Targeting Rap1b and Activating Ras-MAPK Signal

    Directory of Open Access Journals (Sweden)

    Ming Liu

    2018-03-01

    Full Text Available Preeclampsia is a pregnancy-specific complication defined as newly onset gestational hypertension and proteinuria. Deficiency in placental development is considered as the predominant cause of preeclampsia. Our previous study found that the expression of miR-518b increased significantly in the preeclamptic placentas, indicating the potential participation of this small RNA in the occurrence of preeclampsia. In this study, data analysis using multiple databases predicted Rap1b as a candidate target of miR-518b. An evident decrease in Rap1b expression was observed in preeclamptic placentas when compared with the control placentas, which was negatively correlated with the level of miR-518b. Based on the data of in situ hybridization and immunohistochemistry showing that Rap1b exhibited similar localization with miR-518b in villous cytotrophoblast cells and column trophoblasts, we further explored their function in regulating trophoblast cell proliferation. In HTR8/SVneo cells, exogenous transfection of miR-518b reduced the expression of Rap1b, and dual-luciferase reporter assay validated Rap1b as the direct target of miR-518b. The small RNA could increase the BrdU incorporation and the ratio of cells at S phase, and enhance the phosphorylation of Raf-1 and ERK1/2. Such growth-promoting effect could be efficiently reversed by Rap1b overexpression. The data indicate that miR-518b can promote trophoblast cell proliferation via Rap1b–Ras–MAPK pathway, and the aberrant upregulation of miR-518b in preeclamptic placenta may contribute to the excessive trophoblast proliferation. The study provides new evidence to further understand the etiology of preeclampsia.

  2. MiR-203 involves in neuropathic pain development and represses Rap1a expression in nerve growth factor differentiated neuronal PC12 cells.

    Science.gov (United States)

    Li, Haixia; Huang, Yuguang; Ma, Chao; Yu, Xuerong; Zhang, Zhiyong; Shen, Le

    2015-01-01

    Although microRNAs (miRNAs) have been shown to play a role in numerous biological processes, their function in neuropathic pain is not clear. The rat bilateral sciatic nerve chronic constriction injury (bCCI) is an established model of neuropathic pain, so we examined miRNA expression and function in the spinal dorsal horn in bCCI rats. Microarray and real-time polymerase chain reaction were used to examine the expression of miRNA in nerve system of bCCI rats, and the targets of miRNA were predicted by bioinformatic approaches. The function of specific miRNA was estimated through the methods of gene engineering. This study revealed substantially (∼10-fold) decreased miR-203 expression in the spinal dorsal horns but not the dorsal root ganglions, hippocampus, or anterior cingulate cortexes of bCCI rats. Rap1a protein expression was upregulated in bCCI rat spinal dorsal horns. We further verified that miR-203 directly targeted the 3'-untranslated region of the rap1a gene, thereby decreasing rap1a protein expression in neuron-like cells. Rap1a has diverse neuronal functions and their perturbation is responsible for several mental disorders. For example, Rap1a/MEK/ERK is involved in peripheral sensitization. These data suggest a potential role for miR-203 in regulating neuropathic pain development, and Rap1a is a validated target gene in vitro. Results from our study and others indicate the possibility that Rap1a may be involved in pain. We hope that these results can provide support for future research into miR-203 in gene therapy for neuropathic pain.

  3. Bacillus subtilis RapA phosphatase domain interaction with its substrate, phosphorylated Spo0F, and its inhibitor, the PhrA peptide.

    Science.gov (United States)

    Diaz, Alejandra R; Core, Leighton J; Jiang, Min; Morelli, Michela; Chiang, Christina H; Szurmant, Hendrik; Perego, Marta

    2012-03-01

    Rap proteins in Bacillus subtilis regulate the phosphorylation level or the DNA-binding activity of response regulators such as Spo0F, involved in sporulation initiation, or ComA, regulating competence development. Rap proteins can be inhibited by specific peptides generated by the export-import processing pathway of the Phr proteins. Rap proteins have a modular organization comprising an amino-terminal alpha-helical domain connected to a domain formed by six tetratricopeptide repeats (TPR). In this study, the molecular basis for the specificity of the RapA phosphatase for its substrate, phosphorylated Spo0F (Spo0F∼P), and its inhibitor pentapeptide, PhrA, was analyzed in part by generating chimeric proteins with RapC, which targets the DNA-binding domain of ComA, rather than Spo0F∼P, and is inhibited by the PhrC pentapeptide. In vivo analysis of sporulation efficiency or competence-induced gene expression, as well as in vitro biochemical assays, allowed the identification of the amino-terminal 60 amino acids as sufficient to determine Rap specificity for its substrate and the central TPR3 to TPR5 (TPR3-5) repeats as providing binding specificity toward the Phr peptide inhibitor. The results allowed the prediction and testing of key residues in RapA that are essential for PhrA binding and specificity, thus demonstrating how the widespread structural fold of the TPR is highly versatile, using a common interaction mechanism for a variety of functions in eukaryotic and prokaryotic organisms.

  4. 13 CFR 134.409 - Decision on appeal.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Decision on appeal. 134.409 Section 134.409 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING... § 134.409 Decision on appeal. (a) A decision of the Administrative Law Judge under this subpart is the...

  5. 8 CFR 1103.3 - Denials, appeals, and precedent decisions.

    Science.gov (United States)

    2010-01-01

    ... types of cases may be appealed. Decisions under the appellate jurisdiction of the Board of Immigration... argument regarding appeal before AAU—(1) Request. If the affected party desires oral argument, the affected party must explain in writing specifically why oral argument is necessary. For such a request to be...

  6. 20 CFR 405.715 - Agreement in expedited appeals process.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Agreement in expedited appeals process. 405.715 Section 405.715 Employees' Benefits SOCIAL SECURITY ADMINISTRATION ADMINISTRATIVE REVIEW PROCESS FOR ADJUDICATING INITIAL DISABILITY CLAIMS Expedited Appeals Process for Constitutional Issues § 405...

  7. 20 CFR 405.701 - Expedited appeals process-general.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Expedited appeals process-general. 405.701 Section 405.701 Employees' Benefits SOCIAL SECURITY ADMINISTRATION ADMINISTRATIVE REVIEW PROCESS FOR ADJUDICATING INITIAL DISABILITY CLAIMS Expedited Appeals Process for Constitutional Issues § 405.701 Expedited...

  8. 7 CFR 400.56 - Administrative appeal exhaustion.

    Science.gov (United States)

    2010-01-01

    ... contained in 7 CFR part 400, subpart J. Administrative remedies through the appeal process must be exhausted prior to any action for judicial review. The approved APH yield determined as a result of the appeal process will be the yield applicable to the crop year. ...

  9. 32 CFR 150.21 - Appeals by the United States.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Appeals by the United States. 150.21 Section 150... the United States. (a) Restricted filing. Only a representative of the government designated by the Judge Advocate General of the respective service may file an appeal by the United States under Article...

  10. 42 CFR 430.3 - Appeals under Medicaid.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Appeals under Medicaid. 430.3 Section 430.3 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... Provisions § 430.3 Appeals under Medicaid. Three distinct types of disputes may arise under Medicaid. (a...

  11. Teaching Students How To Read Fear Appeals Critically.

    Science.gov (United States)

    Lively, Malcolm

    Fear appeals are persuasive messages that emphasize harmful physical or social consequences of failing to comply with message recommendations. Protection Motivation Theory (PMT) emphasizes cognitive or rational reactions to fear appeals and identifies four message components which initiate corresponding cognitive mediating processes of appraising…

  12. 28 CFR 16.84 - Exemption of Immigration Appeals System.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Exemption of Immigration Appeals System... MATERIAL OR INFORMATION Exemption of Records Systems Under the Privacy Act § 16.84 Exemption of Immigration...) Decisions of the Board of Immigration Appeals (JUSTICE/BIA-001). This exemption applies only to the extent...

  13. 28 CFR 0.116 - Board of Immigration Appeals.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Board of Immigration Appeals. 0.116 Section 0.116 Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE DEPARTMENT OF JUSTICE Executive Office for Immigration Review § 0.116 Board of Immigration Appeals. The Board of Immigration...

  14. 21 CFR 1.401 - Who is entitled to appeal?

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Who is entitled to appeal? 1.401 Section 1.401 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL GENERAL ENFORCEMENT REGULATIONS Administrative Detention of Food for Human or Animal Consumption What Is the Appeal...

  15. 6 CFR 13.39 - Appeal to Authority Head.

    Science.gov (United States)

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Appeal to Authority Head. 13.39 Section 13.39 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.39 Appeal to Authority Head. (a) Any Defendant who has served a timely answer and who is...

  16. 32 CFR 1901.41 - Establishment of appeals structure.

    Science.gov (United States)

    2010-07-01

    ... Establishment of appeals structure. (a) In general. Two administrative entities have been established by the... 32 National Defense 6 2010-07-01 2010-07-01 false Establishment of appeals structure. 1901.41... of Information Act. Their membership, authority, and rules of procedure are as follows. (b...

  17. 22 CFR 61.7 - Review and appeal procedures.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Review and appeal procedures. 61.7 Section 61.7 Foreign Relations DEPARTMENT OF STATE PUBLIC DIPLOMACY AND EXCHANGES WORLD-WIDE FREE FLOW OF AUDIO-VISUAL MATERIALS § 61.7 Review and appeal procedures. (a) An applicant may request a formal review of any adverse...

  18. 40 CFR 27.41 - Stay pending appeal.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Stay pending appeal. 27.41 Section 27.41 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROGRAM FRAUD CIVIL REMEDIES § 27.41 Stay pending appeal. (a) An initial decision is stayed automatically pending disposition of a...

  19. 28 CFR 71.41 - Stay pending appeal.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Stay pending appeal. 71.41 Section 71.41 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) IMPLEMENTATION OF THE PROVISIONS OF THE PROGRAM....41 Stay pending appeal. (a) An initial decision is stayed automatically pending disposition of a...

  20. 15 CFR 25.41 - Stay pending appeal.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Stay pending appeal. 25.41 Section 25.41 Commerce and Foreign Trade Office of the Secretary of Commerce PROGRAM Fraud Civil Remedies § 25.41 Stay pending appeal. (a) An initial decision is stayed automatically pending disposition of a...

  1. 34 CFR 33.41 - Stay pending appeal.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Stay pending appeal. 33.41 Section 33.41 Education Office of the Secretary, Department of Education PROGRAM FRAUD CIVIL REMEDIES ACT § 33.41 Stay pending appeal. (a) An initial decision is stayed automatically pending disposition of a motion for...

  2. 5 CFR 185.141 - Stay pending appeal.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Stay pending appeal. 185.141 Section 185.141 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PROGRAM FRAUD CIVIL REMEDIES § 185.141 Stay pending appeal. (a) An initial decision is stayed automatically pending...

  3. 41 CFR 105-70.041 - Stay pending appeal.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Stay pending appeal. 105... Administration 70-IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 105-70.041 Stay pending appeal. (a) An initial decision is stayed automatically pending disposition of a motion for reconsideration...

  4. 20 CFR 802.105 - Stay of payment pending appeal.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Stay of payment pending appeal. 802.105... PROCEDURE General Provisions Introductory § 802.105 Stay of payment pending appeal. (a) As provided in... ten days after it becomes due pending final decision in any proceeding before the Board unless so...

  5. 22 CFR 521.41 - Stay pending appeal.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Stay pending appeal. 521.41 Section 521.41 Foreign Relations BROADCASTING BOARD OF GOVERNORS IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL REMEDIES ACT § 521.41 Stay pending appeal. (a) An initial decision is stayed automatically pending disposition of a...

  6. 22 CFR 35.41 - Stay pending appeal.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Stay pending appeal. 35.41 Section 35.41 Foreign Relations DEPARTMENT OF STATE CLAIMS AND STOLEN PROPERTY PROGRAM FRAUD CIVIL REMEDIES § 35.41 Stay pending appeal. (a) An initial decision is stayed automatically pending disposition of a motion for...

  7. 10 CFR 1013.41 - Stay pending appeal.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Stay pending appeal. 1013.41 Section 1013.41 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) PROGRAM FRAUD CIVIL REMEDIES AND PROCEDURES § 1013.41 Stay pending appeal. (a) An initial decision is stayed automatically pending disposition of a motion for...

  8. 6 CFR 13.41 - Stay pending appeal.

    Science.gov (United States)

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Stay pending appeal. 13.41 Section 13.41 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.41 Stay pending appeal. (a) An Initial Decision is stayed automatically pending disposition of a...

  9. 45 CFR 79.41 - Stay pending appeal.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Stay pending appeal. 79.41 Section 79.41 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROGRAM FRAUD CIVIL REMEDIES § 79.41 Stay pending appeal. (a) An initial decision is stayed automatically pending disposition of a...

  10. 49 CFR 31.41 - Stay pending appeal.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Stay pending appeal. 31.41 Section 31.41 Transportation Office of the Secretary of Transportation PROGRAM FRAUD CIVIL REMEDIES § 31.41 Stay pending appeal. (a) An initial decision is stayed automatically pending disposition of a motion for reconsideration...

  11. 12 CFR 308.540 - Stay pending appeal.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Stay pending appeal. 308.540 Section 308.540... PRACTICE AND PROCEDURE Program Fraud Civil Remedies and Procedures § 308.540 Stay pending appeal. (a) An initial decision is stayed automatically pending disposition of a motion for reconsideration or of an...

  12. 15 CFR 756.2 - Appeal from an administrative action.

    Science.gov (United States)

    2010-01-01

    ... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS APPEALS... Industry and Security, U.S. Department of Commerce, Room 3898, 14th Street and Pennsylvania Avenue, NW... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Appeal from an administrative action...

  13. 11 CFR 4.8 - Appeal of denial.

    Science.gov (United States)

    2010-01-01

    ... been received by the Commission, may appeal the adverse determination or the failure to respond by... writing, shall clearly and prominently state on the envelope or other cover and at the top of the first... will not entertain any appeal from an alleged denial or failure to comply with an oral request. Any...

  14. 5 CFR 890.1210 - Reconsideration and appeal rights.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Reconsideration and appeal rights. 890... and Kuwait and United States Hostages Captured in Lebanon § 890.1210 Reconsideration and appeal rights.... Department of State to reconsider an initial decision it has made denying coverage or a change in the type of...

  15. 77 FR 269 - Matters Related to Patent Appeals

    Science.gov (United States)

    2012-01-04

    ... DEPARTMENT OF COMMERCE United States Patent and Trademark Office Matters Related to Patent Appeals ACTION: Proposed collection; comment request. SUMMARY: The United States Patent and Trademark Office... Matters Related to Patent Appeals comment'' in the subject line of the message. Mail: Susan K. Fawcett...

  16. 20 CFR 410.698 - Dismissal by Appeals Council.

    Science.gov (United States)

    2010-04-01

    ..., Administrative Review, Finality of Decisions, and Representation of Parties § 410.698 Dismissal by Appeals... discontinuance and dismissal. (b) Death of party. Proceedings before the Appeals Council may be dismissed upon death of a party against whom charges have been preferred. (c) Request for review not timely filed. A...

  17. 45 CFR 1336.35 - Appeal of ineligibility.

    Science.gov (United States)

    2010-10-01

    ... proposes are ineligible for funding by the Commissioner of ANA, may appeal the Commissioner's ruling to the... notification. (b) The appeal must clearly identify the issue(s) in dispute and contain a statement of the applicant's position on such issue(s) along with pertinent facts and reasons in support of the position. (c...

  18. 42 CFR 405.853 - Expedited appeals process.

    Science.gov (United States)

    2010-10-01

    ....853 Expedited appeals process. (a) Conditions for use of expedited appeals process (EAP). A party may use the EAP set forth in § 405.718 of this chapter to request court review in place of the ALJ hearing... the request for an EAP. (b) Content of the request for EAP. The request for an EAP: (1) Alleges that...

  19. 42 CFR 405.718 - Expedited appeals process.

    Science.gov (United States)

    2010-10-01

    ... Part A § 405.718 Expedited appeals process. (a) Conditions for use of expedited appeals process (EAP). A party may use the EAP to request court review in place of an administrative law judge (ALJ..., with the request for the EAP. (b) Content of the request for EAP. The request for the EAP: (1) Alleges...

  20. 28 CFR 549.73 - Appealing the fee.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Appealing the fee. 549.73 Section 549.73 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT MEDICAL SERVICES Fees for Health Care Services § 549.73 Appealing the fee. You may seek review of issues related to...

  1. Bottle appeal drifts across the Pacific

    Science.gov (United States)

    Ebbesmeyer, Curtis; Ingraham, W. James, Jr.; McKinnon, Richard; Okubo, Akira; Wang, Dong-Ping; Strickland, Richard; Willing, Peter

    Pacific drift currents were used by a group of oceanographers to estimate the path of a drift bottle that was found on a beach of Barkley Sound in Vancouver Island by Richard Strickland on June 10, 1990. The Chinese rice wine bottle, which remained unopened until December 18, 1991, contained six leaflets, one appealing for the release of China's well-known dissident, Wei Jingsheng. The bottle was one of thousands set adrift as part of a propaganda effort from the islands of Quemoy and Matsu off mainland China shortly after Wei was sentenced in 1979 to 15 years in prison (see Figure 1 for locations). Wei was in poor health and still in prison when the bottle made its way across the Pacific Ocean.

  2. Drawings between Sensory Appeal and Cultural Code

    DEFF Research Database (Denmark)

    Nielsen, Anne Maj

    to the drawing child in ways that affect the drawing. This is important to take into consideration in research. Sensory appeal and cultural codes in analysis and practice Children’s perception and visual experiences contribute to the construction and transformation of meanings and narratives as they are mediated...... to the drawing child in ways that affect the drawing and the mediation of meaning. This should be taken into consideration in research. The aim of this paper is to qualify analysis of drawings as data in empirical research and to reflect upon opportunities for aesthetic learning processes in psycho....... & Nielsen, A.M. (Eds.) Æstetiske læreprocesser – i teori og praksis. (pp. 192 – 220). København: Billesoe & Baltzer. Fink-Jensen, K. (2007). Attunement and Bodily Dialogues in Music Education. Philosophy of Music Education Review, 15, no 1, 53 - 68. Keller, C. & Keller, J.D. (1993). Thinking and acting...

  3. Rhoptry-associated protein (rap-1) genes in the sheep pathogen Babesia sp. Xinjiang: Multiple transcribed copies differing by 3' end repeated sequences.

    Science.gov (United States)

    Niu, Qingli; Marchand, Jordan; Yang, Congshan; Bonsergent, Claire; Guan, Guiquan; Yin, Hong; Malandrin, Laurence

    2015-07-30

    Sheep babesiosis occurs mainly in tropical and subtropical areas. The sheep parasite Babesia sp. Xinjiang is widespread in China, and our goal is to characterize rap-1 (rhoptry-associated protein 1) gene diversity and expression as a first step of a long term goal aiming at developing a recombinant subunit vaccine. Seven different rap-1a genes were amplified in Babesia sp. Xinjiang, using degenerate primers designed from conserved motifs. Rap-1b and rap-1c gene types could not be identified. In all seven rap-1a genes, the 5' regions exhibited identical sequences over 936 nt, and the 3' regions differed at 28 positions over 147 nt, defining two types of genes designated α and β. The remaining 3' part varied from 72 to 360 nt in length, depending on the gene. This region consists of a succession of two to ten 36 nt repeats, which explains the size differences. Even if the nucleotide sequences varied, 6 repeats encoded the same stretch of amino acids. Transcription of at least four α and two β genes was demonstrated by standard RT-PCR. Copyright © 2015 Elsevier B.V. All rights reserved.

  4. Performance evaluation of reactor operated zircaloy-2 pressure tubes of RAPS-1

    International Nuclear Information System (INIS)

    Chatterjee, S.; Ramadasan, E.; Balakrishnan, K.S.; Bahl, J.K.

    1992-01-01

    Detailed post irradiation examination was carried out on pressure tube sections from E-10, F-9 and F-10 locations of RAPS-1 after an in-reactor residence equivalent to 3.6 effective full power years. The F-10 pressure tube was studied in detail on sections obtained from one end to the other, whereas in the case of E-9 and F-9 pressure tubes only the end sections were examined. The studies carried out were visual examination, metallography, hydrogen i.e. H(D) analysis and mechanical testing at 300 C. Microstructural observations revealed uniform and random hydride/deuteride platelet distribution and absence of blisters or hydride segregation. The H(D) content in the F-10 pressure tube was found to vary in the range 6-12 ppm. The typical H(D) content in the three tubes was around 1 ppm. The H(D) pick-up evaluated from the observed oxide layer thickness was 8 ppm. Longitudinal tensile specimens fabricated from the F-10 pressure tube section and tested at 300 C exhibited increase in yield strength and tensile strength of 39% and 30% respectively. The residual uniform elongation was typically 1.8%. The observed changes in the tensile properties were found to be lower than those reported on unstressed specimens irradiated to similar neutron fluences. The observed hydrogen content and tensile properties obtained in F-10 pressure tube would not be detrimental under normal reactor operating conditions. (author). 10 refs., 4 figs., 2 tabs., 1 annexure

  5. 75 FR 69827 - Rules of Practice Before the Board of Patent Appeals and Interferences in Ex Parte Appeals

    Science.gov (United States)

    2010-11-15

    ... clarify and simplify petitions practice on appeal. For example, except under limited circumstances, any... rule indicates a Board preference for citations to certain reporters and for limited use of non-binding... first time after a notice of appeal is filed, specifically in an examiner's answer. Proposed Bd.R. 41.40...

  6. Appeal to fear in health care: appropriate or inappropriate?

    Science.gov (United States)

    Simpson, J Keith

    2017-01-01

    This paper examines appeal to fear in general: its perceived positive aspects, its negative characteristics, its appropriate as well as its fallacious use. Appeal to fear is a commonly used marketing method that attempts to change behaviour by creating anxiety in those receiving a fearful message. It is regularly used in public health initiatives such as anti-smoking, anti-drunk driving campaigns as well as in hypertension awareness campaigns. Some chiropractors appear to use appeal to fear to promote subluxation awareness and thereby encourage the use of chiropractic treatment. Research supporting its use is equivocal; nevertheless, when used judiciously, appeal to fear probably has sufficient strengths to warrant its continued conditional use. When used to promote care for which there is no supporting evidence, its use is fallacious. Appeal to fear has been used in health promotion campaigns for sixty years or more with the intent of modifying behaviours. While there is evidence to suggest that appeal to fear may motivate some individuals to modify offending behaviour or adopt recommended behaviour there is growing resistance to the use of appeal to fear on ethical and psychological grounds. Using appeal to fear as a tool of persuasion can be valid or fallacious depending on the truth of the premises within the argument. When used to raise awareness about genuine health concerns such as smoking, drunk driving and hypertension appeal to fear is considered to be a valid approach with certain caveats. However, when appeal to fear, not based on evidence or reason, is used as motivator to get others to accept unnecessary interventions for unproven disorders, the use of appeal to fear is fallacious. In spite of the evidence against its use, it seems likely that appeal to fear will continue to be used in conjunction with other public awareness initiatives to modify recognized detrimental behaviours such as smoking and drunk driving as well as silent killers such as

  7. O circuito rap “indé” em Paris: dinâmicas socioterritoriais e mensagem ultramar

    Directory of Open Access Journals (Sweden)

    Cristiano Nunes Alves

    2016-05-01

    Full Text Available Aborda-se o circuito rap independente em Paris, o chamado “rap indé”, produção musical da cultura hip hop, constituída por materialidades e fluxos dinamizados por agentes cujas raízes estão em territórios ultramarinos. Lançando mão de um levantamento documental e bibliográfico, e, de uma série de entrevistas e visitas técnicas, problematiza-se a relação do hip hop com o lugar, e propõe-se uma análise do rap indé a partir da teoria dos circuitos da economia urbana nos países subdesenvolvidos. Observa-se que o circuito indé, fortalecido na Île-de-France, sobretudo desde meados dos anos 1990, mobiliza toda a região, tendo em Clignancourt, importante lugar de encontro e articulação.  Sua produção dá-se em estúdios e selos de menor porte, caracterizando-se ainda por pequenas espessuras ligadas aos eventos musicais, e, divulgação e comercialização alternativas aos grandes circuitos da economia. Trata-se de um estudo buscando alternativas para pensar os modos de se analisar, a partir da música, as dinâmicas socioterritoriais na cidade contemporânea.

  8. miR-203a is involved in HBx-induced inflammation by targeting Rap1a

    Energy Technology Data Exchange (ETDEWEB)

    Wu, AiRong [Department of gastroenterology, The First affiliated Hospital of Soochow University, Suzhou 215006 (China); Chen, Huo [Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123 (China); Xu, ChunFang [Department of gastroenterology, The First affiliated Hospital of Soochow University, Suzhou 215006 (China); Zhou, Ji; Chen, Si [Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123 (China); Shi, YuQi [Department of gastroenterology, The First affiliated Hospital of Soochow University, Suzhou 215006 (China); Xu, Jie [Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123 (China); Gan, JianHe, E-mail: j_pzhang@suda.edu.cn [Department of gastroenterology, The First affiliated Hospital of Soochow University, Suzhou 215006 (China); Zhang, JinPing, E-mail: ganjianhe@aliyun.com [Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123 (China)

    2016-11-15

    Hepatitis B virus (HBV) causes acute and chronic hepatitis, and is one of the major causes of cirrhosis and hepatocellular carcinoma. Accumulating evidence suggests that inflammation is the key factor for liver cirrhosis and hepatocellular carcinoma. MicroRNAs play important roles in many biological processes. Here, we aim to explore the function of microRNAs in the HBX-induced inflammation. First, microarray experiment showed that HBV{sup +} liver samples expressed higher level of miR-203a compared to HBV{sup -} liver samples. To verify these alterations, HBx-coding plasmid was transfected into HepG2 cells to overexpress HBx protein. The real-time PCR results suggested that over-expression of HBx could induce up-regulation of miR-203a. To define how up-regulation of miR-203a can induce liver cells inflammation, we over-expressed miR-203a in HepG2 cells. Annexin V staining and BrdU staining suggested that overexpression of miR-203a significantly increased the cell apoptosis and proliferation, meanwhile, over-expression of miR-203a could lead to a decrease in G0/G1 phase cells and an increase in G2/M phase cells. Some cytokines production including IL-6 and IL-8 were significantly increased, but TGFβ and IFNγ were decreased in miR-203a over-expressed HepG2 cells. Luciferase reporter assay experiments, protein mass-spectrum assay and real-time PCR all together demonstrated that Rap1a was the target gene of miR-203a. Further experiments showed that these alterations were modulated through PI3K/ERK/p38/NFκB pathways. These data suggested that HBV-infection could up-regulate the expression of miR-203a, thus down regulated the expression of Rap1a and affected the PI3K/ERK/p38/NFκB pathways, finally induced the hepatitis inflammation. - Highlights: • HBX induces the over-expression of miR-203a in HepG2 cells. • miR-203a targets Rap1a to induce the inflammation in HepG2 cells. • miR-203a regulates the apoptosis and cell cycles of HepG2 cells. • miR-203a alters

  9. Rediseño y fabricación de una impresora 3D RepRap.

    OpenAIRE

    Huertas González, Joan

    2014-01-01

    El objetivo principal de este proyecto es conseguir las habilidades necesarias para fabricar una impresora 3D del tipo Rep Rap, una tipología de impresoras Open source. Una vez conseguido este objetivo se rediseñan piezas de la propia impresora con el objetivo de mejorar el diseño actual. Se plantea el proyecto como iniciación al mundo de la impresión 3D y de los materiales plásticos con los que se puede trabajar, PLA, HDPE, ABS o NYLON. Se instruye al lector para que tambié...

  10. RAP-3A Computer code for thermal and hydraulic calculations in steady state conditions for fuel element clusters

    International Nuclear Information System (INIS)

    Popescu, C.; Biro, L.; Iftode, I.; Turcu, I.

    1975-10-01

    The RAP-3A computer code is designed for calculating the main steady state thermo-hydraulic parameters of multirod fuel clusters with liquid metal cooling. The programme provides a double accuracy computation of temperatures and axial enthalpy distributions of pressure losses and axial heat flux distributions in fuel clusters before boiling conditions occur. Physical and mathematical models as well as a sample problem are presented. The code is written in FORTRAN-4 language and is running on a IBM-370/135 computer

  11. Rap como identidade cultural negra e periférica: a aversão de rappers brasileiros a Rede Globo

    OpenAIRE

    Júnior, Francisco Carlos Guerra de Mendonça

    2014-01-01

    Dissertação de Mestrado em Comunicação e Jornalismo, apresentada à Faculdade de Letras da Universidade de Coimbra. O rap (rhythm and poetry – ritmo e poesia) é a vertente musical do movimento hip hop, que surgiu nos Estados Unidos na década de 1960. Além do rap, o hip hop conta com MC´s (Mestres de Cerimônia), os DJ´s (disc-joqueys), a dança (break dance) e a pintura (grafith). O rap passou a ser um método utilizado para conscientizar a população sobre os problemas vivenciados pelos negros...

  12. Rivaroxaban in antiphospholipid syndrome (RAPS) protocol: a prospective, randomized controlled phase II/III clinical trial of rivaroxaban versus warfarin in patients with thrombotic antiphospholipid syndrome, with or without SLE.

    Science.gov (United States)

    Cohen, H; Doré, C J; Clawson, S; Hunt, B J; Isenberg, D; Khamashta, M; Muirhead, N

    2015-09-01

    The current mainstay of the treatment of thrombotic antiphospholipid syndrome (APS) is long-term anticoagulation with vitamin K antagonists (VKAs) such as warfarin. Non-VKA oral anticoagulants (NOACs), which include rivaroxaban, have been shown to be effective and safe compared with warfarin for the treatment of venous thromboembolism (VTE) in major phase III prospective, randomized controlled trials (RCTs), but the results may not be directly generalizable to patients with APS. The primary aim is to demonstrate, in patients with APS and previous VTE, with or without systemic lupus erythematosus (SLE), that the intensity of anticoagulation achieved with rivaroxaban is not inferior to that of warfarin. Secondary aims are to compare rates of recurrent thrombosis, bleeding and the quality of life in patients on rivaroxaban with those on warfarin. Rivaroxaban in antiphospholipid syndrome (RAPS) is a phase II/III prospective non-inferiority RCT in which eligible patients with APS, with or without SLE, who are on warfarin, target international normalized ratio (INR) 2.5 for previous VTE, will be randomized either to continue warfarin (standard of care) or to switch to rivaroxaban. Intensity of anticoagulation will be assessed using thrombin generation (TG) testing, with the primary outcome the percentage change in endogenous thrombin potential (ETP) from randomization to day 42. Other TG parameters, markers of in vivo coagulation activation, prothrombin fragment 1.2, thrombin antithrombin complex and D-dimer, will also be assessed. If RAPS demonstrates i) that the anticoagulant effect of rivaroxaban is not inferior to that of warfarin and ii) the absence of any adverse effects that cause concern with regard to the use of rivaroxaban, this would provide sufficient supporting evidence to make rivaroxaban a standard of care for the treatment of APS patients with previous VTE, requiring a target INR of 2.5. © The Author(s) 2015.

  13. Efficient transcription of the glycolytic gene ADH1 and three translational component genes requires the GCR1 product, which can act through TUF/GRF/RAP binding sites.

    Science.gov (United States)

    Santangelo, G M; Tornow, J

    1990-01-01

    Glycolytic gene expression in Saccharomyces cerevisiae is thought to be activated by the GCR and TUF proteins. We tested the hypothesis that GCR function is mediated by TUF/GRF/RAP binding sites (UASRPG elements). We found that UASRPG-dependent activation of a heterologous gene and transcription of ADH1, TEF1, TEF2, and RP59 were sensitive to GCR1 disruption. GCR is not required for TUF/GRF/RAP expression or in vitro DNA-binding activity. Images PMID:2405258

  14. What's so appealing? An examination of emotional appeals and viewer engagement in safe-sex PSAs and condom advertisements.

    Science.gov (United States)

    Stevens, Elise M

    2018-01-01

    Whereas advertisements strive to increase revenue, PSAs work to educate and inform. Even though both share the similar goal of persuasion, advertising tends to lead to more effective sales, unlike PSAs, which can have little effect on audience behaviors. Using a systematic, quantitative content analysis, this study examines emotional appeals and viewer engagement in safe-sex PSAs and condom advertisements in online videos (N = 132). PSAs with humor appeals received more viewer attention in terms of views, comments, and ratings than humorous advertisements. Recommendations for designing public health campaigns are discussed in terms of specific appeals for garnering audience attention.

  15. Fear appeals in HIV-prevention messages: young people's ...

    African Journals Online (AJOL)

    A total of 10 focus groups were conducted to investigate the role of fear appeals ... Young people were shown a series of images (mostly posters) with ... locally conceived rather than ones developed by large-scale donor-funded campaigns.

  16. 45 CFR 1210.3-6 - Appeal of termination.

    Science.gov (United States)

    2010-10-01

    ... Director. The appeal must be in writing and specify the reasons for the Volunteer's disagreement with the... Examiner must possess the qualifications specified in Appendix A to this part, and may not be an employee...

  17. Music and the Three Appeals of Classical Rhetoric

    Science.gov (United States)

    LeCoat, Gerard G.

    1976-01-01

    Contends that rhetorical theory of the sixteenth through the eighteenth centuries influenced the theory of the composition of music and offers examples of vocal music which was adapted to the rhetorical appeals of logos, ethos, and pathos. (MH)

  18. 78 FR 32214 - Land Acquisitions: Appeals of Land Acquisition Decisions

    Science.gov (United States)

    2013-05-29

    ...; 134D0102DR-DS5A300000-DR.5A311.IA000113; Docket ID: BIA-2013-0005] RIN 1076-AF15 Land Acquisitions: Appeals... trust under this part, including broadening notice of any right to file an administrative appeal. DATES... the United States acquired title. See, e.g., Neighbors for Rational Dev., Inc. v. Norton, 379 F.3d 956...

  19. Framing public governance in Malaysia : rhetorical appeals through accrual accounting.

    OpenAIRE

    Ferry, L.; Zakaria, Z.; Zakaria, Z.; Slack, R.

    2017-01-01

    In government, the challenges of governance and anti-corruption are exacerbated by accounting not being fit for purpose. In developing countries, many governments adopt accrual accounting as a panacea. Drawing on Goffman's frame analysis, and rhetorical appeals to logic, credibility and emotion, this paper examines the adoption of accrual accounting in Malaysia. It was found accrual accounting has potential for keying governance and anti-corruption. However, rhetorical appeals that attempt to...

  20. Negative price-image effects of appealing store architecture

    DEFF Research Database (Denmark)

    Zielke, Stephan; Toporowski, Waldemar

    2012-01-01

    Retailers often worry about the negative effects of appealing exterior architecture on their store's price image, especially the price-level perception and the ease of price evaluation. Findings from prior laboratory experiments support these concerns, while field studies find no such effects. Th....... The availability of price information neutralizes the negative effects of appealing architecture on the price-level perception, but not on the ease of price evaluation....

  1. Appeal to fear in health care: appropriate or inappropriate?

    OpenAIRE

    Simpson, J. Keith

    2017-01-01

    Aim This paper examines appeal to fear in general: its perceived positive aspects, its negative characteristics, its appropriate as well as its fallacious use. Background Appeal to fear is a commonly used marketing method that attempts to change behaviour by creating anxiety in those receiving a fearful message. It is regularly used in public health initiatives such as anti-smoking, anti-drunk driving campaigns as well as in hypertension awareness campaigns. Some chiropractors appear to use a...

  2. Administrative Appeals in Romania and Poland - A Topical Comparative Perspective

    Directory of Open Access Journals (Sweden)

    Dacian C. DRAGOŞ

    2012-10-01

    Full Text Available The article focuses on the issue of administrative appeal and analyzes how the appeal functions in two different jurisdictions: Poland and Romania. The authors start by providing information on the nature of the administrative appeal (mandatory or not, deadlines for exercising it, suspensive effect for the action in court etc. All these aspects are examined from a comparative perspective. The aim of the comparative perspective is to highlight that currently the European national systems are fluid and continuously changing; in addition, the goal is to identify best practices that could be transferred from one system to the other. One of the key topics addressed in the context of this theme refers to the relationship that exists between the administrative appeal and the action in court. Authors try to answer the question whether the citizens’ access to justice is breached in cases when the appeal is mandatory. The authors also discuss the fact that very often a mandatory appeal can lead to a high number of cases being solved outside the courts.

  3. 20 CFR 405.725 - Effect of expedited appeals process agreement.

    Science.gov (United States)

    2010-04-01

    ... PROCESS FOR ADJUDICATING INITIAL DISABILITY CLAIMS Expedited Appeals Process for Constitutional Issues § 405.725 Effect of expedited appeals process agreement. After an expedited appeals process agreement is... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Effect of expedited appeals process agreement...

  4. 5 CFR 839.1302 - What types of decisions can I appeal?

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false What types of decisions can I appeal? 839.1302 Section 839.1302 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE... COVERAGE CORRECTIONS ACT Appeal Rights § 839.1302 What types of decisions can I appeal? (a) You can appeal...

  5. 25 CFR 175.62 - Utility actions pending the appeal process.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Utility actions pending the appeal process. 175.62 Section 175.62 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN ELECTRIC POWER UTILITIES Appeals § 175.62 Utility actions pending the appeal process. Pending an appeal, utility...

  6. 7 CFR 868.61 - How to request appeal inspection service.

    Science.gov (United States)

    2010-01-01

    ... may be made with the Board of Appeals and Review or the field office that performed the appeal... application shall be made: (i) Before the rice has left the place where the inspection being appealed was... inspection be based on: (i) The file sample or (ii) a new sample. However, an appeal inspection shall be...

  7. 27 CFR 555.79 - Appeal on petition to the Director.

    Science.gov (United States)

    2010-04-01

    ... for review on appeal with the Director within 15 days of the service of an administrative law judge's..., FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE EXPLOSIVES COMMERCE IN EXPLOSIVES License and Permit... filing an appeal with the U.S. Court of Appeals for judicial review. An appeal may be taken by the...

  8. 24 CFR 15.112 - How will HUD respond to my appeal?

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false How will HUD respond to my appeal... respond to my appeal? (a) How much time does HUD have to decide my appeal? HUD will decide your appeal of a denial of expedited processing within 10 working days after its receipt. For any other type of...

  9. 40 CFR 270.140 - What else must the Director prepare in addition to the draft RAP or notice of intent to deny?

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false What else must the Director prepare in... the Director prepare in addition to the draft RAP or notice of intent to deny? Once the Director has... Regional office or published material that is generally available need not be physically included with the...

  10. Rap and singing are used by music therapists to enhance emotional self-regulation of youth: Results of a survey of music therapists in the Netherlands.

    NARCIS (Netherlands)

    Uhlig, S.; Dimitriadis, Theo; Hackvoort, Laurien; Scherder, E.J.A.

    2016-01-01

    Music therapists use rap and singing for at-risk youth and young adults in different treatment settings. However, it is unclear how often and what kind of interventions they apply, and what kind of treatment goals are pursued. The purpose of this study was to examine approaches of music therapists

  11. Microstructure of shear-induced thixoformed Al- 4.5Cu-1.5Mg alloy via RAP and SSTT processes

    Directory of Open Access Journals (Sweden)

    Siamak Nikzad

    2017-07-01

    Full Text Available In this research, the effect of the thixoforming temperature on the microstructure and mechanical properties was investigated in the thixoforming of the feedstock produced by the RAP (recrystallization and partial melting and SSTT (semi-solid thermal transformation processes for Al-4.5Cu-1.5Mg alloy. In the RAP process, the percentage reduction in area was approximately 35%. Thixoforming was done at 610, 620, and 630 °C. Globular microstructure was observed at all temperatures and conditions. The minimum average globule size was 39 μm, and it was obtained in the thixoforming of the feedstock produced by the RAP process in the section of 4 mm in diameter at 620 ° C after applying shear. Its corresponding compressive strength was -877.44 MPa. The maximum average globule size was 136 μm, and it was obtained in the thixoforming of the feedstock produced by the SSTT process in the section of 10 mm in diameter at 630 °C before applying shear. Its corresponding compressive strength was -769.18 MPa. The finest and most spherical globules, as well as the highest compressive strength were obtained at 620 °C in both RAP and SSTT states.

  12. The non-receptor tyrosine kinase Lyn controls neutrophil adhesion by recruiting the CrkL–C3G complex and activating Rap1 at the leading edge

    Science.gov (United States)

    He, Yuan; Kapoor, Ashish; Cook, Sara; Liu, Shubai; Xiang, Yang; Rao, Christopher V.; Kenis, Paul J. A.; Wang, Fei

    2011-01-01

    Establishing new adhesions at the extended leading edges of motile cells is essential for stable polarity and persistent motility. Despite recent identification of signaling pathways that mediate polarity and chemotaxis in neutrophils, little is known about molecular mechanisms governing cell–extracellular-matrix (ECM) adhesion in these highly polarized and rapidly migrating cells. Here, we describe a signaling pathway in neutrophils that is essential for localized integrin activation, leading edge attachment and persistent migration during chemotaxis. This pathway depends upon Gi-protein-mediated activation and leading edge recruitment of Lyn, a non-receptor tyrosine kinase belonging to the Src kinase family. We identified the small GTPase Rap1 as a major downstream effector of Lyn to regulate neutrophil adhesion during chemotaxis. Depletion of Lyn in neutrophil-like HL-60 cells prevented chemoattractant-induced Rap1 activation at the leading edge of the cell, whereas ectopic expression of Rap1 largely rescued the defects induced by Lyn depletion. Furthermore, Lyn controls spatial activation of Rap1 by recruiting the CrkL–C3G protein complex to the leading edge. Together, these results provide novel mechanistic insights into the poorly understood signaling network that controls leading edge adhesion during chemotaxis of neutrophils, and possibly other amoeboid cells. PMID:21628423

  13. Sequential sentinel SNP Regional Association Plots (SSS-RAP): an approach for testing independence of SNP association signals using meta-analysis data.

    Science.gov (United States)

    Zheng, Jie; Gaunt, Tom R; Day, Ian N M

    2013-01-01

    Genome-Wide Association Studies (GWAS) frequently incorporate meta-analysis within their framework. However, conditional analysis of individual-level data, which is an established approach for fine mapping of causal sites, is often precluded where only group-level summary data are available for analysis. Here, we present a numerical and graphical approach, "sequential sentinel SNP regional association plot" (SSS-RAP), which estimates regression coefficients (beta) with their standard errors using the meta-analysis summary results directly. Under an additive model, typical for genes with small effect, the effect for a sentinel SNP can be transformed to the predicted effect for a possibly dependent SNP through a 2×2 2-SNP haplotypes table. The approach assumes Hardy-Weinberg equilibrium for test SNPs. SSS-RAP is available as a Web-tool (http://apps.biocompute.org.uk/sssrap/sssrap.cgi). To develop and illustrate SSS-RAP we analyzed lipid and ECG traits data from the British Women's Heart and Health Study (BWHHS), evaluated a meta-analysis for ECG trait and presented several simulations. We compared results with existing approaches such as model selection methods and conditional analysis. Generally findings were consistent. SSS-RAP represents a tool for testing independence of SNP association signals using meta-analysis data, and is also a convenient approach based on biological principles for fine mapping in group level summary data. © 2012 Blackwell Publishing Ltd/University College London.

  14. 43 CFR 2.30 - How do I file an appeal?

    Science.gov (United States)

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false How do I file an appeal? 2.30 Section 2.30... INFORMATION ACT FOIA Appeals § 2.30 How do I file an appeal? (a) You must submit your appeal in writing, i.e... appeal will not begin to run until the documents are received. (c) You also should include in as much...

  15. Comprehensive behavioral analysis of mice deficient in Rapgef2 and Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap small GTPases possessing the Ras/Rap-associating domain.

    Science.gov (United States)

    Maeta, Kazuhiro; Hattori, Satoko; Ikutomo, Junji; Edamatsu, Hironori; Bilasy, Shymaa E; Miyakawa, Tsuyoshi; Kataoka, Tohru

    2018-05-10

    Rapgef2 and Rapgef6 define a subfamily of guanine nucleotide exchange factors for Rap small GTPases, characterized by the possession of the Ras/Rap-associating domain. Previous genomic analyses suggested their possible involvement in the etiology of schizophrenia. We recently demonstrated the development of an ectopic cortical mass (ECM), which resembles the human subcortical band heterotopia, in the dorsal telencephalon-specific Rapgef2 conditional knockout (Rapgef2-cKO) brains. Additional knockout of Rapgef6 in Rapgef2-cKO mice resulted in gross enlargement of the ECM whereas knockout of Rapgef6 alone (Rapgef6-KO) had no discernible effect on the brain morphology. Here, we performed a battery of behavioral tests to examine the effects of Rapgef2 or Rapgef6 deficiency on higher brain functions. Rapgef2-cKO mice exhibited hyperlocomotion phenotypes. They showed decreased anxiety-like behavior in the elevated plus maze and the open-field tests as well as increased depression-like behavior in the Porsolt forced swim and tail suspension tests. They also exhibited increased sociability especially in novel environments. They showed defects in cognitive function as evidenced by reduced learning ability in the Barnes circular maze test and by impaired working memory in the T maze tests. In contrast, although Rapgef6 and Rapgef2 share similarities in biochemical roles, Rapgef6-KO mice exhibited mild behavioral abnormalities detected with a number of behavioral tests, such as hyperlocomotion phenotype in the open-field test and the social interaction test with a novel environment and working-memory defects in the T-maze test. In conclusion, although there were differences in their brain morphology and the magnitude of the behavioral abnormalities, Rapgef2-cKO mice and Rapgef6-KO mice exhibited hyperlocomotion phenotype and working-memory defect, both of which could be recognized as schizophrenia-like behavior.

  16. E3B1, a human homologue of the mouse gene product Abi-1, sensitizes activation of Rap1 in response to epidermal growth factor

    International Nuclear Information System (INIS)

    Jenei, Veronika; Andersson, Tommy; Jakus, Judit; Dib, Karim

    2005-01-01

    E3B1, a human homologue of the mouse gene product Abi-1, has been implicated in growth-factor-mediated regulation of the small GTPases p21 Ras and Rac. E3b1 is a regulator of Rac because it can form a complex with Sos-1 and eps8, and such a Sos-1-e3B1-eps8 complex serves as a guanine nucleotide exchange factor for Rac. In the present study, we found that overexpression of e3B1 in NIH3T3/EGFR cells sensitized EGF-induced activation of Rac1, whereas it had no impact on EGF-induced activation of p21 Ras . Remarkably, we found that EGF-induced activation of the p21 Ras -related GTPase Rap1 was also sensitized in NIH3T3/EGFR-e3B1 cells. Thus, in NIH3T3/EGFR-e3B1 cells, maximal EGF-induced activation of Rap1 occurs with a dose of EGF much lower than in NIH3T3/EGFR cells. We also report that overexpression of e3B1 in NIH3T3/EGFR cells renders EGF-induced activation of Rap1 completely dependent on Src tyrosine kinases but not on c-Abl. However, EGF-induced tyrosine phosphorylation of the Rap GEF C3G occurred regardless of whether e3B1 was overexpressed or not, and this did not involve Src tyrosine kinases. Accordingly, we propose that overexpression of e3B1 in NIH3T3/EGFR cells leads to mobilization of Src tyrosine kinases that participate in EGF-induced activation of Rap1 and inhibition of cell proliferation

  17. Økologisk risikovurdering af en genmodificeret glyfosat-tolerant raps GT73 i anmeldelse til godkendelse vedr. import til markedsføring under forordning 1829/2003/EF

    DEFF Research Database (Denmark)

    Kjellsson, Gøsta; Sørensen, Jesper Givskov; Damgaard, Christian

    2012-01-01

    "BIOSCIENCE konklusioner vedr. den økolo-giske risikovurdering af den genmodifice-rede GT73-raps i Danmark Den genmodificerede raps, GT73, adskiller sig fra konventionel raps ved at have indsat gener der gør planten tolerant over for herbicidet glyfosat. Rapsen søges kun godkendt til import til f...... to monitor such dispersal of the GMO-plant into cultivated fields and surroundings. Although, not directly an environmental issue, dispersal of the GT73 could result in problems for co-existence with non-GMO-cultivation. "...

  18. Økologisk risikovurdering af en genmodificeret glyfosat-tolerant raps GT73 i anmeldelse til godkendelse vedr. import til markedsføring under Forordning 1829/2003/EF

    DEFF Research Database (Denmark)

    Damgaard, Christian; Sørensen, Jesper Givskov; Kjellsson, Gøsta

    2012-01-01

    BIOSCIENCE konklusioner vedr. den økolo-giske risikovurdering af den genmodifice-rede GT73-raps i Danmark Den genmodificerede raps, GT73, adskiller sig fra konventionel raps ved at have indsat gener der gør planten tolerant over for herbicidet glyfosat. Rapsen søges kun godkendt til import til fo...... to monitor such dispersal of the GMO-plant into cultivated fields and surroundings. Although, not directly an environmental issue, dispersal of the GT73 could result in problems for co-existence with non-GMO-cultivation....

  19. Artificial intelligence methodologies applied to quality control of the positioning services offered by the Red Andaluza de Posicionamiento (RAP network

    Directory of Open Access Journals (Sweden)

    Antonio José Gil

    2012-12-01

    Full Text Available On April 26, 2012, Elena Giménez de Ory defend-ed her Ph.D. thesis at University of Jaén, entitled: “Robust methodologies applied to quality control of the positioning services offered by the Red Andaluza de Posicionamiento (RAP network”. Elena Giménez de Ory defended her dissertation in a publicly open presentation held in the Higher Polytechnic School at the University of Jaén, and was able to comment on every question raised by her thesis committee and the audience. The thesis was supervised by her advisor, Prof. Antonio J. Gil Cruz, and the rest of his thesis committee, Prof. Manuel Sánchez de la Orden, Dr. Antonio Miguel Ruiz Armenteros and Dr. Gracia Rodríguez Caderot. The thesis has been read and approved by his thesis committee, receiving the highest rating. All of them were present at the presentation.

  20. Mental health message appeals and audience engagement: Evidence from Australia.

    Science.gov (United States)

    Yap, Jo En; Zubcevic-Basic, Nives; Johnson, Lester W; Lodewyckx, Michaela A

    2017-09-07

    Social media platforms are increasingly used to disseminate social marketing messages about mental health and wellbeing. This study presents a range of message appeals used in social media enabled mental health promotion and stigma reduction messages. Furthermore, it examines the relationship between the type of message appeals and audience engagement. A content analysis of 65 organisation-generated YouTube videos about depression and anxiety and stigma reduction was conducted. The most utilised message appeal was Sorrow, followed by Affiliation, Ease/Convenience, Hope, Humour, Guilt/Shame, Heroic/Successful, and Fear. Multiple regression analysis was used to examine the relationship between the type of message appeals and audience engagement in terms of the number of likes, comments, and shares. The analysis revealed that Sorrow is the most useful message appeal for generating audience comments. However, Sorrow is negatively associated with the number of likes and shares. The results suggest that mental health promotion messages may engage a larger audience through Affiliation and Hope as they have a positive impact on the number of shares. This could, in effect, turn audiences into vocal advocates for mental health promotion and stigma reduction messages. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  1. Beholder and Beheld: A Multilevel Model of Perceived Sexual Appeal.

    Science.gov (United States)

    Mackaronis, Julia E; Strassberg, Donald S; Cundiff, Jeanne M; Cann, Deanna J

    2015-11-01

    When individuals (observers) assess how appealing they find sexual stimuli (targets), which factors matter and to whom? The present study examined how observer and target characteristics interact and impact perceived sexual appeal. Participants were 302 men (206 heterosexual, 96 gay) and 289 women (196 heterosexual, 93 lesbian) between the ages of 18 and 67 years, who viewed 34 photographs of targets of their preferred gender and rated each target for sexual appeal, masculinity-femininity, and estimated age. Participants also rated their own masculinity-femininity. A baseline model indicated that roughly 30 % of the variance in sexual appeal ratings was at the observer level (between observers) and 70 % of the variance was at the target level (within observers). In the final model, five characteristics of the participant observers (gender, sexual orientation, age, race/ethnicity, and self-described masculinity-femininity) and six characteristics of the target photographs (gender, whether the photographs were taken from heterosexual versus gay/lesbian media, race/ethnicity, perceived masculinity-femininity, and estimated age) were independently and interactively related to observer ratings of target sexual appeal. Observers displayed preferences for similar targets in terms of race/ethnicity and masculinity-femininity, while also displaying a general preference for target youth. Variation in the strength of these preferences occurred according to observers' own gender, race/ethnicity, masculinity-femininity, and sexual orientation.

  2. Accounting standards that appeal to the professional

    Directory of Open Access Journals (Sweden)

    Alain BURLAUD

    2016-12-01

    In order to observe, in a scientific manner, this evolution of the accounting standards, we conducted a content analysis of principal legislative accounting texts, international and national (France and Romania, supplemented by a lexicometric analysis. These analyses allowed us to conclude that the importance of professional judgment in accounting standards is lower at the national level than it is at the international level. However, we highlight a number of dangers related to an increased use of professional judgment: loss of comparability and transparency, increased risks for accounting professionals including auditors, and significant discrepancies in the use of professional judgment in individual or consolidated accounts

  3. Rap jako muzyka tożsamościowa: od czarnego getta do polskiego pop-nacjonalizmu

    Directory of Open Access Journals (Sweden)

    Piotr Majewski

    2016-01-01

    Full Text Available Rap as identity music: from the black ghetto to Polish pop-nationalism In today’s world, cultural products, technologies, information and ideologies more and more permeate from one society to another, crossing all kinds of borders in the least expected way. Rap career is an illustration of this process. It was created in the late seventies and eighties of the twentieth century in New York ghettos and today it represents one of the most popular genres on the global scale. Rap is not only a symbol of revolution and the domination of Western capitalist business practices but also a cultural tool by which different groups, often marginalized or considering themselves as such, express their own identity. I am analyzing the indicated above phenomenon using two, extreme at first glance, examples. First, I present the story of the emergence and development of hip-hop culture in the United States. I try to show how rap music, which is an important element of this culture, allowed a marginalized part of American society for manifesting and communicating their views, beliefs and values, becoming a “transmission channel” for various ideologies, including the ideology of black nationalism. In the second part of the text, I am additionally analyzing the artwork and public appearances by Tadeusz “Tadek“ Polkowski, a Polish rapper, whom I consider a representative of an expanding hip-hop society relating to or sympathizing with the national movement. The music he creates is designed not only to restore the Poles’ “memory”, and therefore also the pride in their heroic and admirable past, but also to open their eyes to what is happening in their country that he believes is being colonized by the occupants.   Rap jako muzyka tożsamościowa: od czarnego getta do polskiego pop-nacjonalizmu We współczesnym świecie wytwory kultury, technologie, informacje i ideologie coraz częściej przenikają z jednego społeczeństwa do drugiego, przekraczaj

  4. Fear appeals in HIV prevention: the role of anticipated regret.

    Science.gov (United States)

    Smerecnik, Chris M R; Ruiter, Robert A C

    2010-10-01

    The present study examined the role of a number of cognitive beliefs (i.e. attitude, subjective norm, anticipated regret, and self-efficacy) in explaining the effects of fear appeal information on behavioral motivation. A randomized experiment with a 2 (threat: low versus high) × 2 (coping: low versus high) between-subjects design was used in the study. Undergraduates were exposed to one of four scenario messages that presented high or low threat information about HIV/AIDS combined with high or low coping information with regard to condom use in HIV prevention. Explorative analyses revealed that only anticipated regret qualified as a mediator of the effect of the fear appeal message on intention. High coping information was observed to increase anticipated regret, which increased the intention to use condoms. Anticipated regret mediated the coping-intention relationship. This finding furthers our understanding of the working mechanisms of fear appeals in HIV prevention.

  5. Assessing Youth-Appealing Content in Alcohol Advertisements: Application of a Content Appealing to Youth (CAY) Index.

    Science.gov (United States)

    Padon, Alisa A; Rimal, Rajiv N; DeJong, William; Siegel, Michael; Jernigan, David

    2018-02-01

    Underage drinking is a serious public health problem in the United States, and youth exposure to alcohol advertising has been indicated as a possible contributing factor. Although a number of studies have identified advertising content features that youth find appealing, a key limitation of this research is the absence of a broader tool to examine those features, especially those used by alcohol brands that are popular with underage drinkers. We created an index of content elements found in the research literature to be appealing to youth, and then used this index in a content analysis to identify the degree to which youth-appealing content appeared in a sample of alcohol ads that aired on television shows popular among youth. Finally, using bivariate analysis, we tested the relationship between alcohol brands' use of this content and the popularity of those brands among youth. We found that many of the ads featured youth-appealing content, and that the ads for the alcohol brands most popular among youth had more youth-appealing content than the less popular brands.

  6. Subjective knowledge and fear appeal effectiveness: implications for message design.

    Science.gov (United States)

    Nabi, Robin L; Roskos-Ewoldsen, David; Carpentier, Francesca Dillman

    2008-01-01

    This research investigates the role of perceived health knowledge on the effectiveness of fear-based persuasive appeals. Undergraduates (N = 263) read a strong fear, weak fear, or efficacy-only message encouraging breast or testicular self-examination. As expected, results indicated that men high in subjective knowledge were less reactant and more persuaded by the efficacy-only message whereas those low in subjective knowledge did not evidence this pattern. Contrary to expectation, women high in subjective knowledge had comparable reactions to each of the 3 messages. Implications for fear appeal theory and message design are discussed.

  7. A meta-analysis of fear appeals: implications for effective public health campaigns.

    Science.gov (United States)

    Witte, K; Allen, M

    2000-10-01

    The fear appeal literature is examined in a comprehensive synthesis using meta-analytical techniques. The meta-analysis suggests that strong fear appeals produce high levels of perceived severity and susceptibility, and are more persuasive than low or weak fear appeals. The results also indicate that fear appeals motivate adaptive danger control actions such as message acceptance and maladaptive fear control actions such as defensive avoidance or reactance. It appears that strong fear appeals and high-efficacy messages produce the greatest behavior change, whereas strong fear appeals with low-efficacy messages produce the greatest levels of defensive responses. Future directions and practical implications are provided.

  8. Appeal for legislation on greater safety.

    Science.gov (United States)

    Baillie, Jonathan

    2011-10-01

    An Essex-headquartered company which claims to manufacture the world's leading "brand" of glass vision panel, is calling for legislation to regulate the quality and design of such products. With no statutory governance currently in place, it is concerned that a rash of badly-designed, poorer quality variants, that it says have emerged in recent years, pose a significant self-harm and ligature risk to mentally unwell patients in hospitals, and a potential danger to staff when components like internal fittings and the glass itself, especially should the latter be too thin and thus easy to break, are used as "weapons". HEJ editor Jonathan Baillie reports.

  9. 5 CFR 9701.707 - Appeals of mandatory removal actions.

    Science.gov (United States)

    2010-01-01

    ... employee may appeal such actions to the Mandatory Removal Panel (MRP) established under § 9701.708. (b) Procedures. (1) The MRP will establish procedures for the fair, impartial, and expeditious assignment and... other matters as may be necessary to ensure the operation of the MRP. (2) The MRP will conduct a hearing...

  10. 5 CFR 841.410 - Contents of petition for appeal.

    Science.gov (United States)

    2010-01-01

    ... REGULATIONS (CONTINUED) FEDERAL EMPLOYEES RETIREMENT SYSTEM-GENERAL ADMINISTRATION Government Costs § 841.410... signed by the agency head. Delegation of signatory authority is not permitted. (2) The letter of appeal... benefits as applied to the employees of that agency in the category of employees for which the agency is...

  11. Fascism and Class Discourse: Hitler's Appeals to the Junkers.

    Science.gov (United States)

    Fillippeli, Susan E.

    For the generation of Americans who witnessed and perhaps even fought against the Hitler regime, the consequences of his political manipulation had a significant and tangible impact on their lives. For younger generations it is necessary to work to understand how Hitler constructed his appeals to the German people. While a great deal of his…

  12. 33 CFR 20.1003 - Procedures for appeal.

    Science.gov (United States)

    2010-07-01

    ... OF PRACTICE, PROCEDURE, AND EVIDENCE FOR FORMAL ADMINISTRATIVE PROCEEDINGS OF THE COAST GUARD Appeals... appellate brief with the Commandant at the following address: U.S. Coast Guard Administrative Law Judge... refer to the pertinent parts of the record. (3) The appellate brief must reach the Docketing Center 60...

  13. 41 CFR 101-39.103 - Agency appeals.

    Science.gov (United States)

    2010-07-01

    ...-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.1-Establishment, Modification, and Discontinuance of Interagency Fleet... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Agency appeals. 101-39.103 Section 101-39.103 Public Contracts and Property Management Federal Property Management...

  14. 41 CFR 109-39.103 - Agency appeals.

    Science.gov (United States)

    2010-07-01

    ..., AND MOTOR VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.1-Establishment, Modification, and Discontinuance of Interagency Fleet Management Systems § 109-39.103 Agency appeals. The Director, Office of... request exemption from, a determination made by GSA concerning the establishment of a fleet management...

  15. 77 FR 4720 - Appeal Proceedings Before the Commission

    Science.gov (United States)

    2012-01-31

    ... promotes clarity and effectiveness for the regulated community. Proposed subchapter H consists of six parts... Commission and staff turnover and the impact of such turnover on how appeals are handled and decided. This commenter argued that turnover leads to inconsistent outcomes. First, the terms of Commissioners are for a...

  16. 20 CFR 422.205 - Review by Appeals Council.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Review by Appeals Council. 422.205 Section 422.205 Employees' Benefits SOCIAL SECURITY ADMINISTRATION ORGANIZATION AND PROCEDURES Procedures of... the Council. In the event of disagreement between a panel composed of only two members, the Chairman...

  17. 7 CFR 57.370 - Cost of appeals.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Cost of appeals. 57.370 Section 57.370 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE...

  18. 20 CFR 410.707 - Hearings and appeals.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Hearings and appeals. 410.707 Section 410.707 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Rules for the Review of Denied and Pending Claims Under the Black Lung...

  19. Emotional Appeals in HIV Prevention Campaigns: Unintended Stigma Effects.

    Science.gov (United States)

    Thainiyom, Prawit; Elder, Katherine

    2017-07-01

    The purpose of this study was to determine whether HIV/AIDS public service announcements (PSAs) that use emotional appeals have unintended effects of creating stigmatizing attitudes in their viewers. We analyzed data for 240 respondents located in the United States who were recruited online. Respondents were randomly assigned to one of 3 conditions, where they viewed a PSA with hope appeals, fear appeals, or non-emotional appeals. Respondents then answered a series of questions about their attitudes about HIV/AIDS; testing behavior; engagement with HIV/AIDS-related people, organizations, and issues; and HIV/AIDS knowledge. We then performed MANOVA analyses and Pearson correlations. There were no significant differences in stigmatizing attitudes and behavior across the 3 conditions. However, once the data were split by sex, men exposed to the hope condition had significantly higher stigmatizing attitudes towards people living with HIV/AIDS than men in the other 2 conditions. This result was unexpected and suggests that further research needs to be conducted with a more robust sample size to account for any moderating influences that might explain why a hopeful message that communicates togetherness would have a negative attitudinal impact on male viewers.

  20. The aesthetic appeal of depth of field in photographs

    NARCIS (Netherlands)

    Zhang, T.; Nefs, H.T.; Redi, J.; Heynderickx, I.E.J.

    2014-01-01

    We report here how depth of field (DOF) affects the aesthetic appeal of photographs for different content categories. 339 photographs spanning eight categories were selected from Flickr, Google+, and personal collections. First, we classified the 339 photographs into three levels of depth of field:

  1. Self-Report and Psychophysiological Responses to Fear Appeals

    Science.gov (United States)

    Ordonana, Juan R.; Gonzalez-Javier, Francisca; Espin-Lopez, Laura; Gomez-Amor, Jesus

    2009-01-01

    This study was designed to assess the relationship between self-report and psychophysiological responses to fear appeals and behavioral changes elicited by these. Ninety-two subjects watched one of four messages that varied in level of threat (high vs. low) and efficacy (high vs. low). Concomitantly, psychophysiological measures (heart rate and…

  2. 42 CFR 1005.21 - Appeal to DAB.

    Science.gov (United States)

    2010-10-01

    ... initial 30 day period and shows good cause. (b) If a party files a timely notice of appeal with the DAB... and material and that there were reasonable grounds for the failure to adduce such evidence at such... days from the date of mailing. (k) (1) Any petition for judicial review must be filed within 60 days...

  3. Ulpian's Appeal to Nature : Roman Law as Universal Law

    NARCIS (Netherlands)

    Brouwer, René

    2015-01-01

    In this paper I argue that against the political and perhaps even religiously motivated background of the Constitutio Antoniniana, in order to further enhance the appeal of Roman law, Ulpian seeks to connect law and nature by using Stoic terminology. However, his usage of this terminology is

  4. 5 CFR 846.205 - Reconsideration and appeal rights.

    Science.gov (United States)

    2010-01-01

    ... circumstances beyond his or her control from making the request within the time limit. (d) OPM's decision. After... REGULATIONS (CONTINUED) FEDERAL EMPLOYEES RETIREMENT SYSTEM-ELECTIONS OF COVERAGE Elections § 846.205 Reconsideration and appeal rights. (a) Who may file. An individual may request OPM to reconsider a decision of an...

  5. 32 CFR 1907.31 - Right of appeal.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Right of appeal. 1907.31 Section 1907.31 National Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY CHALLENGES TO... this Order. Action by that body will be the subject of rules to be promulgated by the Information...

  6. 27 CFR 24.155 - Disapproval and appeal from disapproval.

    Science.gov (United States)

    2010-04-01

    ..., importation, or transportation of distilled spirits, wine, beer, or other intoxicating liquor. (b) Appeal from... AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS WINE Establishment and Operations Bonds and... officer may disapprove any bonded wine premises bond or consent of surety if the individual, firm...

  7. 42 CFR 438.406 - Handling of grievances and appeals.

    Science.gov (United States)

    2010-10-01

    ... appeals are individuals— (i) Who were not involved in any previous level of review or decision-making; and... in writing. (The MCO or PIHP must inform the enrollee of the limited time available for this in the... and taking other procedural steps. This includes, but is not limited to, providing interpreter...

  8. 43 CFR 6.6 - Appeals by employees.

    Science.gov (United States)

    2010-10-01

    ... Public Lands: Interior Office of the Secretary of the Interior PATENT REGULATIONS Inventions by Employees... a report containing the following information about the invention involved in the appeal: (1) A copy... decision on the matter, which decision shall be final after the period for asking reconsideration expires...

  9. 20 CFR 410.667 - Dismissal by Appeals Council.

    Science.gov (United States)

    2010-04-01

    ..., Administrative Review, Finality of Decisions, and Representation of Parties § 410.667 Dismissal by Appeals... party or parties who filed the request for review to withdraw such request. (b) Death of party... Council, may be dismissed upon the death of a party only if the record affirmatively shows that there is...

  10. How Some Art Museums Can Appeal to Teenagers

    Science.gov (United States)

    Striepe, Susan E.

    2013-01-01

    This article describes a case study that explores the question of how some art museums can appeal to teenagers. The significance of teenagers as the most underrepresented age demographic to visit museums is relevant to current museum practice where visitor studies have assumed increasing importance. As teenagers mature into adults, the long-term…

  11. Functional Effectiveness of Threat Appeals in Exercise Promotion Messages

    Science.gov (United States)

    Brengman, Malaika; Wauters, Birgit; Macharis, Cathy; Mairesse, Olivier

    2010-01-01

    As more than 70% of individuals in Western societies can be categorized as sedentary and inactivity has been recognized to lead to a series of serious physical and psychological disorders, the importance of physical activity promotion is ever more emphasized. Many social marketing campaigns use threat (or fear) appeals to promote healthy…

  12. 20 CFR 638.538 - Disciplinary procedures and appeals.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Disciplinary procedures and appeals. 638.538... disciplinary proceedings, in accordance with procedures developed by the Job Corps Director. Such center... PROGRAM UNDER TITLE IV-B OF THE JOB TRAINING PARTNERSHIP ACT Center Operations § 638.538 Disciplinary...

  13. 75 FR 4783 - Federal Consistency Appeal by Villa Marina Yacht Harbour, Inc.

    Science.gov (United States)

    2010-01-29

    ... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration Federal Consistency Appeal by Villa Marina Yacht Harbour, Inc. AGENCY: National Oceanic and Atmospheric Administration (NOAA... days, closure of the decision record in an administrative appeal filed by Villa Marina Yacht Harbour...

  14. Addiction and Lifestyles in Contemporary Europe: Reframing Addictions Project (ALICE RAP). Final Evaluation Report Deliverable 21.1, Work Package 21

    OpenAIRE

    Mittelmark, Maurice B.

    2016-01-01

    At the onset of the ALICE RAP project, the following objectives, description of work, and main tasks were agreed for Work Package 21: 1. To evaluate the overall functioning of the collaborative research project, using a state-of-art systems model of partnership functioning. 2. To document the interactions and linkages between project inputs, throughputs and outputs as the project unfolds over five years. 3. To facilitate structured discussions involving all pa...

  15. A signaling pathway contributing to platelet storage lesion development: targeting PI3-kinase–dependent Rap1 activation slows storage-induced platelet deterioration

    Science.gov (United States)

    Schubert, Peter; Thon, Jonathan N.; Walsh, Geraldine M.; Chen, Cindy H.I.; Moore, Edwin D.; Devine, Dana V.; Kast, Juergen

    2015-01-01

    BACKGROUND The term platelet storage lesion (PSL) describes the structural and biochemical changes in platelets (PLTs) during storage. These are typified by alterations of morphologic features and PLT metabolism leading to reduced functionality and hence reduced viability for transfusion. While the manifestations of the storage lesion are well characterized, the biochemical pathways involved in the initiation of this process are unknown. STUDY DESIGN AND METHODS A complementary proteomic approach has recently been applied to analyze changes in the PLT proteome during storage. By employing stringent proteomic criteria, 12 proteins were identified as significantly and consistently changing in relative concentration over a 7-day storage period. Microscopy, Western blot analysis, flow cytometry, and PLT functionality analyses were used to unravel the involvement of a subset of these 12 proteins, which are connected through integrin signaling in one potential signaling pathway underlying storage lesion development. RESULTS Microscopic analysis revealed changes in localization of glycoprotein IIIa, Rap1, and talin during storage. Rap1 activation was observed to correlate with expression of the PLT activation marker CD62P. PLTs incubated for 7 days with the PI3-kinase inhibitor LY294002 showed diminished Rap1 activation as well as a moderate reduction in integrin αIIbβ3 activation and release of α-granules. Furthermore, this inhibitor seemed to improve PLT integrity and quality during storage as several in vitro probes showed a deceleration of PLT activation. CONCLUSION These results provide the first evidence for a signaling pathway mediating PSL in which PI3-kinase–dependent Rap1 activation leads to integrin αIIbβ3 activation and PLT degranulation. PMID:19497060

  16. The transnational appeal of Danish TV series

    DEFF Research Database (Denmark)

    Jensen, Pia Majbritt

    because it challenges existing theories on global media geography, import/export of audio-visual content, transnational media reception and the importance of transnational TV viewing. According to these theories, non-Anglophone audio-visual content rarely exports outside its geo-linguistic region...... – in Denmark’s case the Nordic region – because audiences in other regions would be too far removed culturally and linguistically, and hence feel alienated Similarly, theories on the consumption of audio-visual content have neglected transnational, ‘non-resident’, viewing – i.e. when audiences engage...... with audio-visual content removed from their own (cultural) context as would be the case with international audiences engaging with Danish series – and instead emphasized the importance of geo-linguistic, national or ‘resident’ viewing. Even in cases when transnational viewing has been theorized...

  17. appeals among male university students in Western Australia

    Directory of Open Access Journals (Sweden)

    Shahriar Khandaker

    2016-09-01

    Full Text Available Background. Smoking causes ischemic heart disease, cerebrovascular disease, and lung cancer killing 15,000 Australians every year. Despite extensive publicity of the harmful health effects of smoking, one in six Australian aged 15 years and over smoked daily representing 2.7 million active smokers. Objectives. The research aimed to comprehend how active university student smokers respond to different appeals employed in public service antismoking campaigns in Western Australia. Material and methods. The study examined the Quit Victoria 2006–2008 antismoking campaign using qualitative research method involving four in-depth focus group discussions with a total of twenty-four (N = 24 active male university student smokers in Western Australia between the age group of 18 to 24 years. Results . Male university students became active smokers because of the perceived image of ‘coolness,’ ‘macho,’ media influence and experimentation. Impact on sports performances predominantly encouraged respondents in attempting to quit smoking. Sixteen students (67% felt that graphic warning messages on cigarette packs had no effect on them due to desensitizing effects of repeated messages. Twenty-one participants (87.5% felt that health shock appeal was ineffective in making them quit. Emotional appeals like humor, fear, and health shock were most persuasive in advertising messages which would assist in smoking cessation. Therefore, antismoking campaigns with shock health appeals were ineffective in helping smokers to abdicate smoking. Results suggested employing emotional or combination of rational and emotional appeals in maximizing the effectiveness of antismoking advertisements. Conclusions . The study broadens the scope of devising effective antismoking campaigns and provide insightful implications for public health promoters as well as individualized care providers.

  18. Facts versus feelings? The effectiveness of hard versus soft sell appeals in online advertising

    OpenAIRE

    De Veirman, Marijke; Hudders, Liselot; Cauberghe, Veroline

    2015-01-01

    In two experimental studies, the advertising effects of hard versus soft sell appeals are investigated. Both studies show that in online advertising (banner ads and viral video ads), soft sell appeals in advertisements on high involvement products generate a more positive attitude towards the ad than hard sell appeals. In print advertising however, hard sell appeals lead to a more positive Aad, due to the fact that the advertisement is perceived as less irritating and more credible. Additiona...

  19. The effects of emotional and rational news appeals on political attitudes

    OpenAIRE

    Ryffel, Fabian A

    2016-01-01

    The present study investigates how emotional and rational appeals in political news media stories interact with preexisting attitudes in changing citizens’ political attitudes. It is hypothesized that news media appeals that match predispositions are more likely to affect attitudes than mismatching media appeals. That is, people holding attitudes primarily based on affect should be more susceptible to emotionally arousing media content than to rational appeals. For people holding attitudes pr...

  20. EXPERIENCIAS SIGNIFICATIVAS DE INTEGRACIÓN SOCIAL DE UNIVERSITARIOS MEDIANTE LA PRODUCCIÓN TEXTUAL DE RAP I SIGNIFICANT EXPERIENCES OF SOCIAL INTEGRATION OF UNIVERSITY STUDENTS BY TEXTUAL PRODUCTION OF RAP

    Directory of Open Access Journals (Sweden)

    Adriana María Pérez Cedeño

    2018-04-01

    Full Text Available Universities are beginning to promote policies aimed at eliminating discrimination, promoting spaces for community, social and educational participation. Therefore, the incorporation of college students to their academic discourse community is encouraged, since they are young people with a particular history and complex social life, which are included in different ways into the educational system. The overall purpose is to assess the intercultural resource "rap" in the academic practice of textual compositions by new students in the Extensión Región Centro- Sur of the Universidad de Oriente. In this qualitative research, the content analysis is used to account for the experiences of eight key informants interviewed, students of Industrial Engineering or Systems Engineering. It is intended to understand the reasons for the behavior of these students, analyzing both the thematic as the overall quality of writing, the reality in which they arise, and how they express their living experiences. The findings indicate that, despite the difficulties in the writing of texts: a students, in addition to reporting, are identified with this musical style, because its main purpose lies in provoking reactions, b the strategy allows to cater a heterogeneous population academically and culturally, c university students may recognize, as any artistic expression, musical text resulting from this interpretation, which has a social impact in a given group of persons. This strategy provides an opportunity to reflect on the process of integral development and deepens in the construction of a new model of society

  1. Legal Nature of Criminal Proceedings Regarding the Length of the Appeal

    Directory of Open Access Journals (Sweden)

    Constantin Tanase

    2016-05-01

    Full Text Available The appeal regarding length of criminal proceedings represents a new institution of Romanian criminal procedure system, born from the need to align the procedural rules to the constitutional requirements and other internal rules, but especially from the need for harmonization with European Community rules, namely the Convention for the Protection of Human Rights and Fundamental Freedoms. To the same extent, it was aimed at forming a legal institution in line with the jurisprudence of the European Court of Human Rights. The new institution has its registered matter in art. 4881-4886 Criminal Procedure Code., Introduced by Law implementing the Code under Title IV – “Special Procedures” which recommends it from the beginning as a derogation from the common procedure. Nevertheless, given the position of remedy for excessive and unjustified extension of the criminal proceedings, as well as the judicial review, which it triggers in this regard, it raises the question of the legal nature of the appeal regarding the length of criminal proceedings. The answer to this question may affect the correct application of the institution and the improvement of judicial practice.

  2. Fear and Efficacy Appeals in the Classroom: The Secondary Teachers' Perspective

    Science.gov (United States)

    Putwain, David W.; Roberts, Christine M.

    2012-01-01

    Previous research has examined the use of classroom fear and efficacy appeals from a student perspective, but little is known about teachers' views towards fear and efficacy appeals. In this preliminary study, we conducted a survey of 234 secondary school teachers. Results showed that teachers held mixed views towards the use of fear appeals and…

  3. 20 CFR 405.705 - When the expedited appeals process may be used.

    Science.gov (United States)

    2010-04-01

    ... PROCESS FOR ADJUDICATING INITIAL DISABILITY CLAIMS Expedited Appeals Process for Constitutional Issues § 405.705 When the expedited appeals process may be used. If you have filed a disability claim, you may... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false When the expedited appeals process may be...

  4. 20 CFR 405.720 - Notice of agreement to expedite appeal.

    Science.gov (United States)

    2010-04-01

    ....720 Section 405.720 Employees' Benefits SOCIAL SECURITY ADMINISTRATION ADMINISTRATIVE REVIEW PROCESS FOR ADJUDICATING INITIAL DISABILITY CLAIMS Expedited Appeals Process for Constitutional Issues § 405.720 Notice of agreement to expedite appeal. If we agree that you can use the expedited appeals process...

  5. 12 CFR 505.4 - Administrative appeal of initial determination to deny records.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Administrative appeal of initial determination to deny records. 505.4 Section 505.4 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF.... Appeals may be delivered personally to FOIA Appeals, Office of Thrift Supervision, 1700 G Street, NW...

  6. 28 CFR 74.15 - Notice of the right to appeal a finding of ineligibility.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Notice of the right to appeal a finding... LIBERTIES ACT REDRESS PROVISION Appeal Procedures § 74.15 Notice of the right to appeal a finding of... determination, the right to petition for a reconsideration of the determination of ineligibility to the...

  7. 5 CFR 1201.156 - Time for processing appeals involving allegations of discrimination.

    Science.gov (United States)

    2010-01-01

    ... in appeal. When an appellant alleges prohibited discrimination in the appeal, the judge will decide... appeal, but has raised the issue later in the proceeding, the judge will decide both the issue of... remanded to agency. When the judge remands an issue of discrimination to the agency, adjudication will be...

  8. 43 CFR 4.2 - Membership of appeals boards; decisions, functions of Chief Judges.

    Science.gov (United States)

    2010-10-01

    ... direct that an appeal may be decided by a panel of any two Administrative Judges of the Board, but if..., functions of Chief Judges. 4.2 Section 4.2 Public Lands: Interior Office of the Secretary of the Interior... appeals boards; decisions, functions of Chief Judges. (a) The Appeals Boards consist of regular members...

  9. 5 CFR 532.705 - Appeal to the Office of Personnel Management.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Appeal to the Office of Personnel Management. 532.705 Section 532.705 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PREVAILING RATE SYSTEMS Job Grading Reviews and Appeals § 532.705 Appeal to the Office of Personnel Management. (a)(1) An employee may...

  10. The Effects of Repeated Exposure to Graphic Fear Appeals on Cigarette Packages: A Field Experiment

    NARCIS (Netherlands)

    Dijkstra, A.; Bos, C.

    2015-01-01

    Experimental studies on the effects of graphic fear appeals on cigarette packages typically expose smokers in a single session to a fear appeal, although in practice the exposure is always repeated. The present study applied an improved study design with repeated exposure to fear appeals on

  11. 38 CFR 19.50 - Nature and form of administrative appeal.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Nature and form of... (CONTINUED) BOARD OF VETERANS' APPEALS: APPEALS REGULATIONS Administrative Appeals § 19.50 Nature and form of... resolve a conflict of opinion or a question pertaining to a claim involving benefits under laws...

  12. The Effects of Repeated Exposure to Graphic Fear Appeals on Cigarette Packages : A Field Experiment

    NARCIS (Netherlands)

    Dijkstra, Arie; Colin, Bos,

    2015-01-01

    Experimental studies on the effects of graphic fear appeals on cigarette packages typically expose smokers in a single session to a fear appeal, although in practice the exposure is always repeated. The present study applied an improved study design with repeated exposure to fear appeals on

  13. 8 CFR 1003.1 - Organization, jurisdiction, and powers of the Board of Immigration Appeals.

    Science.gov (United States)

    2010-01-01

    ... the Board of Immigration Appeals. 1003.1 Section 1003.1 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE GENERAL PROVISIONS EXECUTIVE OFFICE FOR IMMIGRATION REVIEW Board of Immigration Appeals § 1003.1 Organization, jurisdiction, and powers of the Board of Immigration Appeals. (a)(1...

  14. 8 CFR 1003.2 - Reopening or reconsideration before the Board of Immigration Appeals.

    Science.gov (United States)

    2010-01-01

    ... Board of Immigration Appeals. 1003.2 Section 1003.2 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE GENERAL PROVISIONS EXECUTIVE OFFICE FOR IMMIGRATION REVIEW Board of Immigration Appeals § 1003.2 Reopening or reconsideration before the Board of Immigration Appeals. (a) General...

  15. 49 CFR 821.16 - Interlocutory appeals from law judges' rulings on motions.

    Science.gov (United States)

    2010-10-01

    ... Appealable Orders § 821.16 Interlocutory appeals from law judges' rulings on motions. Rulings of law judges... 49 Transportation 7 2010-10-01 2010-10-01 false Interlocutory appeals from law judges' rulings on motions. 821.16 Section 821.16 Transportation Other Regulations Relating to Transportation (Continued...

  16. 13 CFR 134.709 - When will a Judge dismiss an appeal?

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false When will a Judge dismiss an appeal? 134.709 Section 134.709 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING CASES BEFORE THE OFFICE OF HEARINGS AND APPEALS Rules of Practice for Appeals From Women...

  17. 36 CFR 1270.42 - Denial of access to public; right to appeal.

    Science.gov (United States)

    2010-07-01

    ...; right to appeal. 1270.42 Section 1270.42 Parks, Forests, and Public Property NATIONAL ARCHIVES AND... Denial of access to public; right to appeal. (a) Any person denied access to a Presidential record... library director at the address cited in part 1253 of this chapter. (b) All appeals must be received by...

  18. 36 CFR 1250.76 - May I email my FOIA appeal?

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false May I email my FOIA appeal... email my FOIA appeal? Yes, you may submit a FOIA appeal via email to http://www.archives.gov/global_pages/inquire_form.html. You must put the words “FOIA Appeal” in the subject line of your email message...

  19. 30 CFR 250.104 - How may I appeal a decision made under MMS regulations?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How may I appeal a decision made under MMS... of Terms § 250.104 How may I appeal a decision made under MMS regulations? To appeal orders or decisions issued under MMS regulations in 30 CFR parts 250 to 282, follow the procedures in 30 CFR part 290. ...

  20. 11 CFR 9405.8 - Appeals of denials of requests for records.

    Science.gov (United States)

    2010-01-01

    ... received by the Commission, may appeal the adverse determination or the failure to respond by requesting... occur. (b) The appeal request shall be in writing, shall clearly and prominently state on the envelope... not entertain any appeal from an alleged denial or failure to comply with an oral request. Any person...

  1. 76 FR 37661 - Notification of Anticipated Delay in Administrative Appeal Decisions

    Science.gov (United States)

    2011-06-28

    ... material ``Self-reactive solid, Type F, UN3230.'' Dangerous Goods Transport Appeal focuses on the...] Notification of Anticipated Delay in Administrative Appeal Decisions AGENCY: Pipeline and Hazardous Materials... currently reviewing numerous administrative appeals (i.e., petitions for reconsideration) on recently issued...

  2. 12 CFR 709.8 - Administrative appeal of the initial determination.

    Science.gov (United States)

    2010-01-01

    ... must be in writing and must specify what type of appeal the claimant requests. The determination of... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Administrative appeal of the initial... INVOLVING FEDERALLY INSURED CREDIT UNIONS IN LIQUIDATION § 709.8 Administrative appeal of the initial...

  3. Major international sport profiles.

    Science.gov (United States)

    Patel, Dilip R; Stier, Bernhard; Luckstead, Eugene F

    2002-08-01

    Sports are part of the sociocultural fabric of all countries. Although different sports have their origins in different countries, many sports are now played worldwide. International sporting events bring athletes of many cultures together and provide the opportunity not only for athletic competition but also for sociocultural exchange and understanding among people. This article reviews five major sports with international appeal and participation: cricket, martial arts, field hockey, soccer, and tennis. For each sport, the major aspects of physiological and biomechanical demands, injuries, and prevention strategies are reviewed.

  4. Pricing products: juxtaposing affordability with quality appeal.

    Science.gov (United States)

    1984-01-01

    Choosing appropriate product prices is 1 of the most crucial steps in creating an effective contraceptive social marketing (CSM) sales campaign. The Social Marketing Forum conducted an informal survey of social marketing project managers, international contractors, and marketing consultants to determine how CSM programs cope with pricing problems and ways to circumvent some obstacles. According to Diana Altman, a family planning consultant, low prices that make products available to needy individuals are more important than the program's self sufficiency, yet if prices are too low, consumers think the products were unusable in the US and thus were dumped on local markets. Other key factors include commercial competition, spiraling inflation rates, and problems with rising prices and retailer/distributor margins. A sampling of per capita gross national products indicates the poverty level of most CSM projects' target market. Consequently, CSM projects must set low pices, regardless of program operating costs. The goal often is to increase the demand and availability for contraceptives. The fact that social marketing products must pass through retail networks to reach consumers complicates the pricing equation. To deal with the problem, India's Nirodh program gives a 25% margin to distributors/wholesalers, compared to 6% offered on most other goods. Retailers also receive a 25% margin, more than double the commercial rate. Once prices are set, increases pose hazards. Local government approval often is a prerequisite and can require lengthy negotiations. Market studies remain a valuable approach to effective pricing, according to PNA's Mallamad and other research consultants. They cite such effective research strategies as test marketing products and asking consumers how prices affect buying habits. Further, CSM projects can jump over some pricing hurdles through creative marketing. An effective pricing strategy alone cannot produce a successful CSM program. Pricing

  5. Rap system of stress stimulation can promote bone union after lower tibial bone fracture: a clinical research.

    Science.gov (United States)

    Yao, Jian-fei; Shen, Jia-zuo; Li, Da-kun; Lin, Da-sheng; Li, Lin; Li, Qiang; Qi, Peng; Lian, Ke-jian; Ding, Zhen-qi

    2012-01-01

    Lower tibial bone fracture may easily cause bone delayed union or nonunion because of lacking of dynamic mechanical load. Research Group would design a new instrument as Rap System of Stress Stimulation (RSSS) to provide dynamic mechanical load which would promote lower tibial bone union postoperatively. This clinical research was conducted from January 2008 to December 2010, 92 patients(male 61/female 31, age 16-70 years, mean 36.3 years) who suffered lower tibial bone closed fracture were given intramedullary nail fixation and randomly averagely separated into experimental group and control group(according to the successively order when patients went for the admission procedure). Then researchers analysed the clinical healing time, full weight bearing time, VAS (Visual Analogue Scales) score and callus growth score of Lane-Sandhu in 3,6,12 months postoperatively. The delayed union and nonunion rates were compared at 6 and 12 months separately. All the 92 patients had been followed up (mean 14 months). Clinical bone healing time in experimental group was 88.78±8.80 days but control group was 107.91±9.03 days. Full weight bearing time in experimental group was 94.07±9.81 days but control group was 113.24±13.37 days respectively (Ptibial bone union, reduce bone delayed union or nonunion rate. It is an adjuvant therapy for promoting bone union after lower tibial bone fracture.

  6. MDMA (ecstasy/molly) use among African Americans: The perceived influence of hip-hop/rap music.

    Science.gov (United States)

    Rigg, Khary K; Estreet, Anthony T

    2018-02-12

    Over the past two decades, the demographic profile of MDMA (ecstasy/molly) users has changed. In particular, African American MDMA use has risen in some cities. One explanation of this new trend is the drug's recent popularity (as molly) in hip-hop/rap (HHR) music. Several top rappers endorse the drug as a way to have fun or get women "loose." There are currently no studies, however, that investigate the extent to which African American MDMA users listen to HHR music or the influence that these pro-MDMA messages have on their use of the drug. To address this gap, the current study used survey data to (a) identify the extent to which HHR music is listened to by African American MDMA users and (b) assess the perceived influence of HHR music on their decision to begin using. Qualitative interview data are also presented to contextualize the influence of these messages on their use of MDMA. The findings of this study suggest that African American MDMA users are high consumers of HHR music and that pro-MDMA messages in HHR music are influencing their expectations of the drug and their decision to initiate use. These findings add to the limited amount of research on African American MDMA use and have the potential to inform future interventions.

  7. Environmental performance and mechanical analysis of concrete containing recycled asphalt pavement (RAP) and waste precast concrete as aggregate.

    Science.gov (United States)

    Erdem, Savaş; Blankson, Marva Angela

    2014-01-15

    The overall objective of this research project was to investigate the feasibility of incorporating 100% recycled aggregates, either waste precast concrete or waste asphalt planning, as replacements for virgin aggregates in structural concrete and to determine the mechanical and environmental performance of concrete containing these aggregates. Four different types of concrete mixtures were designed with the same total water cement ratio (w/c=0.74) either by using natural aggregate as reference or by totally replacing the natural aggregate with recycled material. Ground granulated blast furnace slag (GGBS) was used as a mineral addition (35%) in all mixtures. The test results showed that it is possible to obtain satisfactory performance for strength characteristics of concrete containing recycled aggregates, if these aggregates are sourced from old precast concrete. However, from the perspective of the mechanical properties, the test results indicated that concrete with RAP aggregate cannot be used for structural applications. In terms of leaching, the results also showed that the environmental behaviour of the recycled aggregate concrete is similar to that of the natural aggregate concrete. Copyright © 2013 Elsevier B.V. All rights reserved.

  8. Structural integrity test of Indian PHWR containment of Kaiga- 1 and 2 and RAPS- 3 and 4 atomic power stations

    International Nuclear Information System (INIS)

    Samota, Arun; Verma, U.S.P.; Warudkar, A.S.; Mohan, Nalini; Bhawal, R.N.; Bajaj, S.S.

    2002-01-01

    Full text: The structural integrity tests of Kaiga 1, 2 and RAPS 3, 4 primary containment were carried out as per requirements specified in RCC-G code by pressurizing the containment with oil free air at design pressure of 1.73 Kg/cm 2 (g). Dilations were monitored in vertical and radial directions by installing dial gauges at various locations on the outer surface of primary containment. The dilations were generally observed to be linear with the pressure and the residual displacements were within the acceptable limit. Strains were measured in meridional and circumferential directions at different pressure levels by using a large number of different types of strain gauge. While the behaviour of embedded type vibrating wire strain gauges was excellent, the behaviour of surface mounted electrical resistance (SMER) was satisfactory. Other parameters monitored were crack, differential and absolute settlements. No crack was noticed in any of the containment. No absolute and differential settlements were noticed. The results of the tests have demonstrated elastic behaviour of the containment. The acceptance criteria of the tests were met with good margin

  9. Audience Recall of AIDS PSAs among U.S. and International College Students.

    Science.gov (United States)

    Lee, Jung-Sook; Davie, William R.

    1997-01-01

    Shows that audience recall of AIDS public service announcements (PSAs) is related to message appeal types, cultural identity, and gender. Finds that strong emotional appeals are better remembered than rational ones; U.S. viewers recalled more than international participants; and college women recalled more than college men in general, and…

  10. Scaring the Public: Fear Appeal Arguments in Public Health Reasoning

    Directory of Open Access Journals (Sweden)

    Louise Cummings

    2012-03-01

    Full Text Available The study of threat and fear appeal arguments has given rise to a sizeable literature. Even within a public health context, much is now known about how these arguments work to gain the public’s compliance with health recommendations. Notwithstanding this level of interest in, and examination of, these arguments, there is one aspect of these arguments that still remains unexplored. That aspect concerns the heuristic function of these arguments within our thinking about public health problems. Specifically, it is argued that threat and fear appeal arguments serve as valuable shortcuts in our reasoning, particularly when that reasoning is subject to biases that are likely to diminish the effectiveness of public health messages. To this extent, they are rationally warranted argument forms rather than fallacies, as has been their dominant characterization in logic.

  11. Affect Intensity: An Individual Difference Response to Advertising Appeals.

    OpenAIRE

    Moore, David J; Harris, William D; Chen, Hong C

    1995-01-01

    The Affect Intensity Measurement (AIM) scale assesses the strength of the emotions with which individuals respond to an affect-laden stimulus. This study investigated the extent to which individual differences in affect intensity influence the message recipient's responses to emotional advertising appeals. In two experiments high affect intensity individuals, compared with those who scored low on the AIM scale, (1) manifested significantly stronger emotional responses to the emotional adverti...

  12. Are narcissists sexy? Zeroing in on the effect of narcissism on short-term mate appeal.

    Science.gov (United States)

    Dufner, Michael; Rauthmann, John F; Czarna, Anna Z; Denissen, Jaap J A

    2013-07-01

    This research was aimed to provide a comprehensive test of the classic notion that narcissistic individuals are appealing as short-term romantic or sexual partners. In three studies, we tested the hypotheses that narcissism exerts a positive effect on an individual's mate appeal and that this effect is mediated by high physical attractiveness and high social boldness. We implemented a multimethod approach and used ratings of opposite sex persons (Study 1), ratings of friends (Study 2), and records of courtship outcomes in naturalistic interactions (Study 3) as indicators of mate appeal. In all cases, narcissism had a positive effect on mate appeal, which was mainly due to the agentic self-enhancement aspects of narcissism (rather than narcissists' lacking communion). As predicted, physical attractiveness and social boldness mediated the positive effect of narcissism on mate appeal. Findings further indicated that narcissism was more strongly linked to mate appeal than to friend appeal.

  13. Uplifting Fear Appeals: Considering the Role of Hope in Fear-Based Persuasive Messages.

    Science.gov (United States)

    Nabi, Robin L; Myrick, Jessica Gall

    2018-01-09

    Fear appeal research has focused, understandably, on fear as the primary emotion motivating attitude and behavior change. However, while the threat component of fear appeals associates with fear responses, a fear appeals' efficacy component likely associates with a different emotional experience: hope. Drawing from appraisal theories of emotion in particular, this article theorizes about the role of hope in fear appeals, testing hypotheses with two existing data sets collected within the context of sun safety messages. In both studies, significant interactions between hope and self-efficacy emerged to predict behavioral intentions. Notable main effects for hope also emerged, though with less consistency. Further, these effects persisted despite controlling for the four cognitions typically considered central to fear appeal effectiveness. These results, consistent across two samples, support the claim that feelings of hope in response to fear appeals contribute to their persuasive success. Implications for developing a recursive model of fear appeal processing are discussed.

  14. Study of college library appealing information system: A case of Longyan University

    Science.gov (United States)

    Liao, Jin-Hui

    2014-10-01

    The complaints from the readers at university libraries mainly focus on the aspects of service attitude, quality of service, reading environment, the management system, etc. Librarians should realize that reader complaints can actually promote the role of the library service and communicate with readers who complain in a friendly manner. In addition, the Longyan University library should establish an internal management system, improve library hardware facilities, improve the quality of librarians and optimize the knowledge structure of librarians, so as to improve the quality of the service for readers and reduce complaints. Based on this point, we have designed an appealing information system in cryptography machine basis, to provide readers online, remote and anonymous complaint functions.

  15. Functional effectiveness of threat appeals in exercise promotion messages

    Directory of Open Access Journals (Sweden)

    Olivier Mairesse

    2010-01-01

    Full Text Available As more than 70% of individuals in Western societies can be categorized as sedentary and inactivity has been recognized to lead to a series of serious physical and psychological disorders, the importance of physical activity promotion is ever more emphasized. Many social marketing campaigns use threat (or fear appeals to promote healthy behaviors. Theoretical models, such as the Extended Parallel Process Model integrate concepts as 'perceived threat' and 'perceived efficacy' to explain how such messages operate and can cause diverse behavioral reactions. It is however still not entirely clear how these different aspects are valuated and combined to determine desired versus undesired response behaviors in individuals. In a functional integration task, threat-appeal based exercise promotion messages varying in psychological threat and efficacy content were shown to sedentary employees in order to assess how they affect their intention to engage in physical exercise. Our results show that individuals can be categorized in 4 different clusters depending on the way they valuate threat and efficacy appeals: i.e. individuals sensitive to both types of cues, those sensitive to either the threat or the efficacy component in the message and those insensitive to either one of them. As different segments of receivers of the message react differently to threat and efficacy combinations, it is concluded that different approaches to designing effective mass media campaigns may be required for effective exercise promotion.

  16. El vídeo, el cómic y el rap: una forma diferente de desbloquear al candidato del DELE

    Directory of Open Access Journals (Sweden)

    Florencia Battagliero Bocco

    2017-11-01

    Full Text Available Resumen: El objetivo del presente artículo es trabajar y reforzar las destrezas y competencias necesarias para aprobar el Diploma de Español como Lengua Extranjera. Para ello, se planteará una serie de recursos que buscan desbloquear al estudiante en un ambiente distendido, sobre todo los días previos al examen. La propuesta se centrará en la Prueba de Expresión e Interacción Orales, concretamente en la tarea 3 del nivel B1 y en la tarea 2 del nivel B2, que corresponden a la descripción de una fotografía. Se empleará, por una parte, un vídeo de carácter estático (donde el interlocutor no expresa movimientos corporales pronunciados y por otra, cómics de Argentina que a su vez servirán para ampliar el léxico en la variante rioplatense. Por último, se tratará el uso del rap como herramienta para mejorar la pronunciación, entonación y el empleo del lenguaje no verbal. Palabras claves: DELE, vídeo, cómic, rap.   Abstract: The purpose of the following essay is to train and to strengthen the skills and the competences required to pass the “Spanish as a Foreign Language Certificate”. In order to do so, we will first consider various resources which aim to release students from any kind of stress by setting up a relaxed atmosphere – especially a few days before the exam. The focus of the present essay has to be linked to the Expression and Oral Interaction tests and above all to the assignments 3 (B1 level and 2 (B2 level, and their picture descriptions. On the one hand, we will use a static video and, on the other hand, we will tackle Argentinian comics in order to expand students’ knowledge of the Río de la Plata lexicon. Finally, we will deal with the use of rap as a tool to improve pronunciation, intonation, and non-verbal communication. Key words: DELE, video, comic, rap.

  17. Kopūstinės kandies (Plutella xylostella L.) (Lepidoptera: Plutelidae) skraidymo ir kenkimo intensyvumo dinamika vasarinių rapsų ir gūžinių kopūstų pasėliuose

    OpenAIRE

    Vyšniauskaitė, Sigrida

    2013-01-01

    Magistrantūros studijų baigiamajame darbe pateikiami kopūstinės kandies skraidymo bei kenkimo dinamikos vasarinių rapsų ir gūžinių kopūstų pasėliuose tyrimų rezultatai. Darbo objektas – kopūstinė kandis (Plutella xylostella L.) Darbo metodai – kopūstinės kandies skraidymo dinamika tirta naudojant feromonines “delta” tipo gaudykles, 2012 m. gegužės – rugpjūčio mėnesiais, vasarinių rapsų ir ankstyvųjų bei vėlyvųjų baltagūžių kopūstų pasėliuose. Vasarinių rapsų pasėlyje buvo įrengta 12 ga...

  18. METHODOLOGY RELATED TO ESTIMATION OF INVESTMENT APPEAL OF RURAL SETTLEMENTS

    Directory of Open Access Journals (Sweden)

    A. S. Voshev

    2010-03-01

    Full Text Available Conditions for production activity vary considerably from region to region, from area to area, from settlement to settlement. In this connection, investors are challenged to choose an optimum site for a new enterprise. To make the decision, investors follow such references as: investment potential and risk level; their interrelation determines investment appeal of a country, region, area, city or rural settlement. At present Russia faces a problem of «black boxes» represented by a lot of rural settlements. No effective and suitable techniques of quantitative estimation of investment potential, rural settlement risks and systems to make the given information accessible for potential investors exist until now.

  19. Are your numbers up? The psychological appeal of lotteries

    OpenAIRE

    Griffiths, MD

    2010-01-01

    Playing on national lottery games is one of the most popular forms of gambling worldwide and they are also growing in popularity in their many online incarnations. But what is the psychological appeal of an activity where the odds of winning huge jackpot prizes are usually infinitesimal? For instance, the odds of winning the EuroMillions lottery are 76 million to one. I often joke that you would get better odds of Elvis Presley landing on the moon on the back of the Loch Ness Monster!

  20. Causal and Epistemic Relevance in Appeals to Authority

    Directory of Open Access Journals (Sweden)

    Sebastiano Lommi

    2015-05-01

    Full Text Available Appeals to authority have a long tradition in the history of argumentation theory. During the Middle Age they were considered legitimate and sound arguments, but after Locke’s treatment in the Essay Concerning Human Understanding their legitimacy has come under question. Traditionally, arguments from authority were considered informal arguments, but since the important work of Charles Hamblin (Hamblin, 1970 many attempts to provide a form for them have been done. The most convincing of them is the presumptive form developed by Douglas Walton and John Woods (Woods, Walton, 1974 that aims at taking into account the relevant contextual aspects in assessing the provisional validity of an appeal to authority. The soundness of an appeal depends on its meeting the adequacy conditions set to scrutinize all the relevant questions. I want to claim that this approach is compatible with the analysis of arguments in terms of relevance advanced by David Hitchcock (Hitchcock, 1992. He claims that relevance is a triadic relation between two items and a context. The first item is relevant to the second one in a given context. Different types of relevance relation exist, namely causal relevance and epistemic relevance. “Something is [causally] relevant to an outcome in a given situation if it helps to cause that outcome in the situation” (Hitchcock, 1992, p. 253, whereas it is epistemically relevant when it helps to achieve an epistemic goal in a given situation. I claim that we can adapt this conception to Walton and Krabbe’s theory of dialogue type (Walton, Krabbe, 1995, seeing the items of a relevance relation as the argument and its consequence and the context as the type of dialogue in which these arguments are advanced. According to this perspective, an argument from authority that meets the adequacy conditions has to be considered legitimate because it is an epistemically relevant relation. Therefore, my conclusion is that an analysis of appeals to