THE CAPACITY AND CIRCULATION OF PASSENGER TERMINAL BUILDING IN REGIONAL AIRPORT (CASE: MINANGKABAU AND ADISUTJIPTO INTERNATIONAL AIRPORTS OF INDONESIA

Directory of Open Access Journals (Sweden)

Amalia Defiani

2013-05-01

Full Text Available The dissertation explains about capacity and flow inside terminal buildings in two regional airports in Indonesia: Minangkabau and Adisutjipto International Airports. Both airports have similar characteristics of passengers’ number and locations as tourism areas. Secondary data in the form of existing terminal layouts and air traffic numbers were gained from both airports authorities in Indonesia. The analysis was carried out using the formulas from Japan International Cooperation Agency – Directorate General of Civil Aviation of Indonesia(JICA-DGCA studies in 1996 for significant areas in the terminal building, Ashford and Wright formula for calculating aircraft movement per hour, Microsoft Excel for calculating the 10-year passenger growth rate, and SPSS for determining the linear equation for domestic departure resulted in the forecasted saturation in the near 2020 for both of airports, especially on passengers’ handling areas such as boarding lounge (for departure and baggage claim area (for arrival. The research resulted in ideas to overcome problems related to the increasing capacity by adding areas (if possible and changing layouts. Some other options such as implementation of more effective signage and the suggestion of centralizing security checking areas also are being brought—though needed further research. There should be an addition of numbers of security check lines, appropriately to the increasing number of passengers. If a single queuing line creates delays, then the need for extra line(s is a necessity Keywords: Airport, Terminal Building, Capacity, Flow, Minangkabau, Adisutjipto

Feasibility of piezoelectric tiles adoption: A case study at Kuala Lumpur International Airport (KLIA) Malaysia

Science.gov (United States)

Chew, Boon Cheong; Loo, Heoy Shin; Bohari, Izyan Adilah; Hamid, Syaiful Rizal; Sukri, Fatin Hafizah; Kusumarwadani, Rini

2017-03-01

The basic function of an international airport is an aerodrome, provides not only the facilities for flights management, but also for customs and passport control. Nowadays, most of the international airports have established commercial outlets for food, products and services. As such, these airports are built with larger scale and more sophisticated on both infrastructure and infostructure which aim to be the most extensive air-travel service providers that connect the nations to the international gateways. Looking at the daily operations of an international airport, the energy consumption is apprehended to be enormous. Besides, knowing the fact that reliance on fossil fuels to power the airport buildings and to run the operations daily, this has led to many negative socioenvironmental implications. To date, some of the world major international airports have begun in renewable energy adoption-which mainly focused on solar energy as a way to reduce fossil energy consumption and towards greenhouse gases reduction. Inspired by thinking differently since solar energy has been adopted in Kuala Lumpur International Airport (KLIA) in 2014, through this study we proposed another form of renewable energy-piezoelectric technology adoption into our KLIA as a feasibility study. We believe that piezoelectric technology could complement the renewable energy mix, by tapping the crowd kinetic energy gathered internally in the airport buildings particularly at a few main entrances. Hence, the objectives of this study are (a) to examine the potential factors that will foster piezoelectric tiles adoption at KLIA and (b) to propose the ways for KLIA in speeding up piezoelectric tiles adoption within the airport terminals. The case study on the Malaysia Airports Holding Berhad (MAHB which manages the KLIA) was based on primary data collected through a series of qualitative focus group conducted on 14 (8 senior managers and 6 technical professionals) who were interested and supportive

A Comparative Analysis of Three Major Transfer Airports in Northeast Asia Focusing on Incheon International Airport Using a Conjoint Analysis

Directory of Open Access Journals (Sweden)

Tae Won Chung

2017-12-01

Full Text Available Due mainly to the privatization and commercialization of airline companies and deregulation of the aviation rules, the demand for air transport has continuously been increasing. Airport authorities state that transfer passengers, who contribute to the large portion of the airports’ profits, are gaining much more importance, particularly in the Northeast Asia region where the air transport industry is very vital. Therefore, this study aims to investigate the competitiveness of IIA (Incheon International Airport with other major airports located in Northeast Asia in passenger transfers made between Southeast Asia and China to North America using Conjoint Analysis. Results have indicated that airport brand is the most important attribute for the competitiveness of airport, followed by cost, connectivity and duty free shops. In further analysis focusing on brand value of the three airports measured by the use of transfer passengers, it was revealed that IIA needs more effort in developing their brand identity to become the leading transfer hub airport. Based on the results, recommendations for increasing the brand value have also been suggested.

A Study on the Development of Service Quality Index for Incheon International Airport

Science.gov (United States)

Lee, Kang Seok; Lee, Seung Chang; Hong, Soon Kil

2003-01-01

The main purpose of this study is located at developing Ominibus Monitors System(OMS) for internal management, which will enable to establish standards, finding out matters to be improved, and appreciation for its treatment in a systematic way. It is through developing subjective or objective estimation tool with use importance, perceived level, and complex index at international airport by each principal service items. The direction of this study came towards for the purpose of developing a metric analysis tool, utilizing the Quantitative Second Data, Analysing Perceived Data through airport user surveys, systemizing the data collection-input-analysis process, making data image according to graph of results, planning Service Encounter and endowing control attribution, and ensuring competitiveness at the minimal international standards. It is much important to set up a pre-investigation plan on the base of existent foreign literature and actual inspection to international airport. Two tasks have been executed together on the base of this pre-investigation; one is developing subjective estimation standards for departing party, entering party, and airport residence and the other is developing objective standards as complementary methods. The study has processed for the purpose of monitoring services at airports regularly and irregularly through developing software system for operating standards after ensuring credibility and feasibility of estimation standards with substantial and statistical way.

Proposed Strategy Improvement for Ngurah Rai International Airport

OpenAIRE

Ayu, Astrid Puspa; Wandebori, Harimukti

2013-01-01

The number of visitors to Bali is increasing. Indirectly its affect Ngurah Rai International Airport as one of the entrances to Bali to give a good service for their visitors and influence Balinese people about their fear of losing their culture due to other cultures. The analysis consists of Internal and External Analysis. The internal and external analysis consists of Marketing Mix, Value Chain Analysis, PESTEL and Questionnaire. The analysis shows that visitor feel unsatisfied with some of...

Security Requirements for New Threats at International Airports

Directory of Open Access Journals (Sweden)

Gabriel Nowacki

2018-03-01

Full Text Available The paper refers to security requirements for new threats international airports, taking specifically into consideration current challenges within processing of passengers, in light of types of current major threats, in a way ensuring positive passenger experience within their journey. In addition, within the scope of this paper, presented initial outcome of study research among professional aviation stakeholder?s environment, on current threats in the area of security and protection of airport infrastructure. The airports are a very demanding environment: seasonal traffic, fluctuating passenger volumes and last minute changes mean there is a lot of flexibility required in order to meet specific needs of airport authorities and their clients or the passengers (Dolnik, 2009. Therefore, security in aviation sector has been a big issue for civil aviation authorities, as airports are susceptible targets for terrorist attacks. The list of incidents is extensive and gets longer every year despite strict security measures. Within decades, aviation has become the backbone of our global economy bringing people to business, tourists to vacation destinations and products to markets. Statistically flying remains the safest mode of travelling compared to other modes of transportation. However, simultaneously terrorists and criminals continue in their quest to explore new ways of disrupting air transportation and the challenge to secure airports and airline assets remain real. This calls for greater awareness of security concerns in the aviation sector. The key element, how to protects against terrorist modus operandi, is to stay ahead of recent threats, incidents and breaches occurring worldwide. It requires implementation of effective data sharing systems, in order to proactively monitor potential risks and vulnerabilities within different type of aviation ecosystems.

YAP expression in normal and neoplastic breast tissue: an immunohistochemical study.

Science.gov (United States)

Jaramillo-Rodríguez, Yolanda; Cerda-Flores, Ricardo M; Ruiz-Ramos, Ruben; López-Márquez, Francisco C; Calderón-Garcidueñas, Ana Laura

2014-04-01

Yes-associated protein (YAP) is a transcriptional factor involved in normal cell proliferation, apoptosis and carcinogenesis; however, its contribution to breast cancer (BC) is still controversial. We undertook this study to compare the expression of YAP by immunohistochemistry (IHC) in normal breast tissue of women without breast cancer (BC) (controls), non-neoplastic breast tissue in women with cancer (internal controls) and in four different subtypes of invasive ductal carcinoma. There were 17 controls and 105 tumor cases (53 luminal A, 15 luminal B, 20 overexpression of HER2 and 17 triple negative cases) studied by IHC. Statistical analysis included χ(2) for linear trend (Extended Mantel-Haenszel). There were 40% of internal controls that showed expression of YAP in myoepithelial cells, whereas in controls expression was 100%. In controls, 3/17 (17.6%) showed cytoplasmic staining in luminal cells. There was a significant difference in nuclear expression between the ductal BC subtypes. Luminal A had 4% of positive cases with <10% of cells affected in each case; in contrast, there were 17-20% of positive cases in the other groups with 50% or more of stained cells. YAP expression in stromal cells was not observed in controls or in triple-negative cases, and luminal B pattern had the highest YAP nuclear expression (20%). YAP showed decreased expression in tumor cells compared with normal breast tissue. These findings are consistent with a role of YAP as a suppressor gene in BC and show differences in YAP expression in different patterns of ductal BC. Copyright © 2014 IMSS. Published by Elsevier Inc. All rights reserved.

75 FR 54695 - Noise Exposure Map Notice; Brownsville South Padre Island International Airport, Brownsville, TX

Science.gov (United States)

2010-09-08

...; Brownsville South Padre Island International Airport, Brownsville, TX AGENCY: Federal Aviation Administration... that the noise exposure maps submitted by the City of Brownsville, Texas for Brownsville South Padre... that the noise exposure maps submitted for Brownsville South Padre Island International Airport are in...

78 FR 41184 - Noise Exposure Map Notice for Hilo International Airport, Hilo, Hawaii

Science.gov (United States)

2013-07-09

... International Airport, Hilo, Hawaii AGENCY: Federal Aviation Administration, (FAA), DOT. ACTION: Notice. SUMMARY: The FAA announces its determination that the noise exposure maps submitted by Hawaii State Department...-Pacific Region, Honolulu Airports District Office, 300 Ala Moana Boulevard, Room 7-128, Honolulu, Hawaii...

75 FR 52819 - Public Notice for Waiver of Aeronautical Land-Use Assurance; Rickenbacker International Airport...

Science.gov (United States)

2010-08-27

...-aid funding from the FAA. The disposition of proceeds from the disposal of the airport property will... Municipal Airport Authority by deed of record in Official Record 514, Page 2561, (all references are to the... Aeronautical Land-Use Assurance; Rickenbacker International Airport, Columbus, OH AGENCY: Federal Aviation...

19 CFR 122.15 - User fee airports.

Science.gov (United States)

2010-04-01

... Airport. Egg Harbor Township, New Jersey Atlantic City International Airport. Englewood, Colorado... Airport. Hillsboro, Oregon Hillsboro Airport. Johnson City, New York Binghamton Regional Airport. Lansing..., California Southern California Logistics Airport. Waterford, Michigan Oakland County International Airport...

76 FR 12404 - Noise Exposure Map Notice; Jackson-Evers International Airport, Jackson, MS

Science.gov (United States)

2011-03-07

...: Jonathan Linquist, Federal Aviation Administration, Jackson Airports District Office, 100 West Cross Street... section 150.7 of Part 150 includes: Figure 1-1, Jackson-Evers International Airport and Surrounding...-2, Runways 16L/16R Radar and Modeled Flight Tracks for Departures and Arrivals; Figure 5-3, Runways...

77 FR 23598 - Technical Amendment to Cuba Airport List: Addition of Recently Approved Airports

Science.gov (United States)

2012-04-20

... burdens on, nor takes away any existing rights or privileges from the public, pursuant to 5 U.S.C. 553(b... special procedures that apply to all aircraft (except public aircraft) entering or departing the United... International Airport, Los Angeles International Airport, or Miami International Airport. In a statement issued...

78 FR 9449 - Noise Exposure Map Notice, Southwest Florida International Airport, Fort Myers, FL

Science.gov (United States)

2013-02-08

... Aviation Administration, Orlando Airports District Office, 5950 Hazeltine National Drive Citadel International Building, Suite 400, Orlando, FL 32822, 407-812-6331. SUPPLEMENTARY INFORMATION: This notice... Abatement Act (the Act), an airport operator may submit to the FAA Noise Exposure Maps which meet applicable...

Application of Artificial Neural Network to Predict the use of Runway at Juanda International Airport

Science.gov (United States)

Putra, J. C. P.; Safrilah

2017-06-01

Artificial neural network approaches are useful to solve many complicated problems. It solves a number of problems in various areas such as engineering, medicine, business, manufacturing, etc. This paper presents an application of artificial neural network to predict a runway capacity at Juanda International Airport. An artificial neural network model of backpropagation and multi-layer perceptron is adopted to this research to learning process of runway capacity at Juanda International Airport. The results indicate that the training data is successfully recognizing the certain pattern of runway use at Juanda International Airport. Whereas, testing data indicate vice versa. Finally, it can be concluded that the approach of uniformity data and network architecture is the critical part to determine the accuracy of prediction results.

77 FR 2605 - Public Notice for Waiver of Aeronautical Land-Use Assurance; Gerald R. Ford International Airport...

Science.gov (United States)

2012-01-18

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Public Notice for Waiver of Aeronautical Land-Use Assurance; Gerald R. Ford International Airport, Grand Rapids, MI AGENCY: Federal... this FAA action may be reviewed at this same location or at Gerald R. Ford International Airport, Grand...

Postnatal growth of children in relation to noise from Osaka International Airport

Science.gov (United States)

Schell, L. M.; Ando, Y.

1991-12-01

This paper examines the effects of different levels of exposure to airport noise on the physical growth of children. Heights and weights of 6686 three-year-old boys and girls were measured between April 1972 and March 1974. These children are grouped into one of five exposure levels according to their exposure to noise from nearby Osaka International Airport in Japan. The frequency of growth inhibition is examined in each noise group and compared across groups. The frequency of very short boys and girls (less than 87 cm) increases significantly ( p short stature (10th percentile of local standards), the presence of moderate growth inhibition also is related to the level of airport noise, more so in males than females. With a third and less restrictive definition (less than 91 cm), the association is still present. Parallel analyses with weight did not find significant effects of noise exposure. We conclude that airport noise exposure may be related to a greater frequency of children of very small stature. We interpret this as evidence for a long-term physical effect of airport noise on children.

Investigation of the electromagnetic radiation field level in the vicinity of Damascus international airport

International Nuclear Information System (INIS)

Abukassem, I.

2011-07-01

The aim of this work is to estimate the electromagnetic radiation exposure of Damascus international airport workers.Different kinds of electromagnetic wave sources exist in the vicinity of the airport, for example, mobile phone base stations. It was found that the exposure level in all studied points (offices, halls, traffic control tour, etc) is lower than the international restriction levels. Few recommendations were given for some work situation or places where the measured electromagnetic radiation levels were relatively high.(author)

Designing Shopping Area Atmospheric Using Choice-based Conjoint Analysis: Case Study at Soekarno-Hatta International Airport

Directory of Open Access Journals (Sweden)

Suzianti Amalia

2017-01-01

Full Text Available As a response to overcapacity issue at Soekarno-Hatta International Airport, the government is recently planning on building larger terminal buildings to transport passengers. However, in designing an excellent terminal building, one should not only consider how to process passengers in the most efficient way, but also how facility-based environmental cues, or atmospheric cues, affect consumers’ emotional state and shopping behavior. This research aims at examining passenger preferences towards atmospheric cues in airport shopping area and proposing a shopping area design based on consumer preferences. Choice-based conjoint was conducted towards 500 passengers at Soekarno-Hatta International Airport. Research findings suggested that there is a significant correlation between atmospheric cues and consumers’ purchase intention in airport shopping area. Passengers prefer a shopping area with high in-store visibility, cool colors for window display, floors, wall, and ceiling, and bright lighting for airport hallway. This research also concludes that Socio-economic Status (SES affects passengers’ preferences.

76 FR 55158 - Approval of Noise Compatibility Program for Lambert-St. Louis International Airport, St. Louis, MO

Science.gov (United States)

2011-09-06

... Program for Lambert-St. Louis International Airport, St. Louis, MO AGENCY: Federal Aviation Administration... noise compatibility program submitted by the St. Louis Airport Authority under the provisions of 49 U.S...''). On April 5, 2011, the FAA determined that the noise exposure maps submitted by the St. Louis Airport...

Nuisance Caused by Aircraft Noise in the Vicinity of Tehran International Airport

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Stan Frost

1999-03-01

Full Text Available Noise measurement and social questionnaire surveys in three residential areas around Mehrabad International Airport (Tehran, Iran were based upon randomly selected dwellings in each area. A total of 193 individuals responded and many are annoyed and dissatisfied with aircraft noise and in consequence they would like to move. Aircraft noise is the strongest negative environmental factor affecting the residents in the vicinity of Mehrabad Airport and it could be a hazard for their health.

14 CFR Appendix D to Part 91 - Airports/Locations: Special Operating Restrictions

Science.gov (United States)

2010-01-01

... International Airport) Boston, MA (General Edward Lawrence Logan International Airport) Chantilly, VA... (Miami International Airport) Minneapolis, MN (Minneapolis-St. Paul International Airport) Newark, NJ.../Washington International Airport) Boston, MA (General Edward Lawrence Logan International Airport) Buffalo...

SOME ISSUES OF THE AIRPORT MANAGEMENT

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Marian Ovidiu

2012-07-01

Full Text Available Internationally, the recommended standards for the operation and management of civil-use airports are provided by the International Civil Aviation Organization (ICAO. In most individual countries, airports are managed directly by the government, most often under the ministry of transport. In some countries, including EU countries, some airports are privately owned and operated, although, despite private ownership, they are still subject to much of the country’s regulations regarding aviation operations. The complex system of civil airports is made up of individual airport facilities of varying sizes, serving various purposes, all organized into plans of regional, national, and international levels. The range of rules, regulations, and policies, administered from varying levels of government, cover the full spectrum of airport and aviation system operations. Furthermore, a large number of professional and industry organizations play a large part in influencing the policies by which airport management must operate their facilities. By understanding where an airport manager’s airport falls within the civil aviation system, what rules must be followed, and what sources of support and assistance exist, the task of efficiently managing the complex system that is an airport, becomes highly facilitated.

Long term performance of the reef runway at Honolulu International Airport

CSIR Research Space (South Africa)

Magoon, OT

2007-07-01

Full Text Available Completed in 1977, the Reef Runway embankment at Honolulu International Airport was created by placing and compacting millions of cubic meters of dredged coral fill material over an existing coral reef. The wave protection structure on the deeper...

77 FR 17492 - Expansion of Global Entry to Additional Airports

Science.gov (United States)

2012-03-26

...--Logan International Airport, Boston, Massachusetts (BOS); Las Vegas--McCarran International Airport, Las... following four additional airports: St. Paul International Airport, Minneapolis, Minnesota (MSP); Charlotte...

The Distribution and Environmental Impacts of Noise Pollution Sadouqi Martyr Yazd International Airport Using GIS

Directory of Open Access Journals (Sweden)

H Zarei Mahmoud Abadi

2016-03-01

Full Text Available Introduction: Persecutors of aircraft noise at an airport has a close relationship with the alternate of landing and take-off weight of the aircraft and operations planning during the night. Now aircraft that spill in Yazd airport and take-off of aircraft is of jet engines or so-turbofan mean that the resulting sound will be very high. Methods: In this descriptive, cross-sectional  measurement of noise from aircraft traffic noise measuring station 7,The completed questionnaires to assess the effects of noise pollution in Yazd International Airport and the surrounding noise sensitive areas in 2014 by a portable audio device measurement is done. Results: The most amount of noise caused by aircraft traffic in the airport area and in adjacent areas with average noise level 84.8 dB at station No. 5 Regional Airport, located south of the airport, with an average noise level which was 75.5 dB. The results of analysis of questionnaires showed that 75 percent of people living in residential areas around the airport are being harassed by aircraft noise. Results indicate that, sleep disorders, nervousness, stress and mental illness and interfere with speech, regardless of the priority of different factors in the study area, are of the highest impact of aircraft noise. Conclusion: Aircraft noise is the strongest negative environmental factors that affect employees and residents around Yazd International Airport and can be harmful to health. The noise for health personnel, particularly those of daily tasks, are daily exposed to aircraft intense noise , are highly undesirable. So, essentially preventive severe conditions such as mandatory use of protective devices and soundproof acoustic shortening service personnel are needed for these people.

EVALUATION OF ALTERNATIVE RAILWAY CONNECTION ACCESS AT JAKARTA SOEKARNO HATTA INTERNATIONAL AIRPORT

Directory of Open Access Journals (Sweden)

Ayu Aprilischa

2015-01-01

Full Text Available Traveling between the center of Jakarta and Soekarno Hatta International Airport (SHIA is further constrained by the limited number of main routes available which likely cannot be accommodated in the future by road based transport modes alone. Hence, the airport needs to develop airport surface access to accommodate its network. The aim of this research is to analyze the railway access system for developing the system of SHIA using multi criteria analysis in the selection of alternative route alignment of the railway line and a qualitative study in data collection within the research design. Development of the criteria includes technical, economic, environmental and spatial aspect. Three alternatives have been proposed in this analysis, i.e. through West Jakarta, through North and West Jakarta and through North and Central Jakarta. The results show that alternative 3 (through North and Central Jakarta can give implications to the airport users, i.e. providing a high standard of the rail link in a well-timed manner and a cost-effective public transport link. Improving the multi-modal access to the airport will improve the supply of employment to business, lead to urban regeneration around station locations, and improve Greater Jakarta Metropolitan Area regional competitiveness.

GATEWAY Report Brief: SSL Evaluation: Philadelphia International Airport Apron Lighting

Energy Technology Data Exchange (ETDEWEB)

None, None

2015-10-30

Summary of report that documents a trial installation of LED apron lighting that replaced the existing high-pressure sodium luminaires at Philadelphia International Airport. Such high-mast applications remain challenging for LED technology, and the lessons learned from this project may help facility managers and LED product manufacturers better meet those challenges.

Denver's airport of doom; the story behind the world's possibly most controversial airport

NARCIS (Netherlands)

Stolwijk, J.

2014-01-01

Big airport projects have often been prone to controversy. Schiphol’s Polderbaan project, Heathrow’s expansion, and the construction of Berlin’s new airport all suffered from political, financial or technical issues. However, Denver International Airport (often referred to as DIA) caused uproar in

Increasing Walking in the Hartsfield-Jackson Atlanta International Airport: The Walk to Fly Study.

Science.gov (United States)

Fulton, Janet E; Frederick, Ginny M; Paul, Prabasaj; Omura, John D; Carlson, Susan A; Dorn, Joan M

2017-07-01

To test the effectiveness of a point-of-decision intervention to prompt walking, versus motorized transport, in a large metropolitan airport. We installed point-of-decision prompt signage at 4 locations in the airport transportation mall at Hartsfield-Jackson Atlanta International Airport (Atlanta, GA) at the connecting corridor between airport concourses. Six ceiling-mounted infrared sensors counted travelers entering and exiting the study location. We collected traveler counts from June 2013 to May 2016 when construction was present and absent (preintervention period: June 2013-September 2014; postintervention period: September 2014-May 2016). We used a model that incorporated weekly walking variation to estimate the intervention effect on walking. There was an 11.0% to 16.7% relative increase in walking in the absence of airport construction where 580 to 810 more travelers per day chose to walk. Through May 2016, travelers completed 390 000 additional walking trips. The Walk to Fly study demonstrated a significant and sustained increase in the number of airport travelers choosing to walk. Providing signage about options to walk in busy locations where reasonable walking options are available may improve population levels of physical activity and therefore improve public health.

Volcanic hazards to airports

Science.gov (United States)

Guffanti, M.; Mayberry, G.C.; Casadevall, T.J.; Wunderman, R.

2009-01-01

Volcanic activity has caused significant hazards to numerous airports worldwide, with local to far-ranging effects on travelers and commerce. Analysis of a new compilation of incidents of airports impacted by volcanic activity from 1944 through 2006 reveals that, at a minimum, 101 airports in 28 countries were affected on 171 occasions by eruptions at 46 volcanoes. Since 1980, five airports per year on average have been affected by volcanic activity, which indicates that volcanic hazards to airports are not rare on a worldwide basis. The main hazard to airports is ashfall, with accumulations of only a few millimeters sufficient to force temporary closures of some airports. A substantial portion of incidents has been caused by ash in airspace in the vicinity of airports, without accumulation of ash on the ground. On a few occasions, airports have been impacted by hazards other than ash (pyroclastic flow, lava flow, gas emission, and phreatic explosion). Several airports have been affected repeatedly by volcanic hazards. Four airports have been affected the most often and likely will continue to be among the most vulnerable owing to continued nearby volcanic activity: Fontanarossa International Airport in Catania, Italy; Ted Stevens Anchorage International Airport in Alaska, USA; Mariscal Sucre International Airport in Quito, Ecuador; and Tokua Airport in Kokopo, Papua New Guinea. The USA has the most airports affected by volcanic activity (17) on the most occasions (33) and hosts the second highest number of volcanoes that have caused the disruptions (5, after Indonesia with 7). One-fifth of the affected airports are within 30 km of the source volcanoes, approximately half are located within 150 km of the source volcanoes, and about three-quarters are within 300 km; nearly one-fifth are located more than 500 km away from the source volcanoes. The volcanoes that have caused the most impacts are Soufriere Hills on the island of Montserrat in the British West Indies

Use of social media by airports

OpenAIRE

Halpern, Nigel

2012-01-01

Purpose: This study investigates use of social media by airports according to geographical location of the airport, airport size, and airport ownership and operation. Design/methodology/approach: The study is based on a content analysis of airport websites. The sample consists of 1559 airports worldwide that are members of Airports Council International (ACI). Findings: Almost one-fifth of airports use at least one type of social media; 13% use Facebook, 12% use Twitter, 7% use LinkedIn...

cAMP/PKA signalling reinforces the LATS–YAP pathway to fully suppress YAP in response to actin cytoskeletal changes

Science.gov (United States)

Kim, Minchul; Kim, Miju; Lee, Seunghee; Kuninaka, Shinji; Saya, Hideyuki; Lee, Ho; Lee, Sookyung; Lim, Dae-Sik

2013-01-01

Actin cytoskeletal damage induces inactivation of the oncoprotein YAP (Yes-associated protein). It is known that the serine/threonine kinase LATS (large tumour suppressor) inactivates YAP by phosphorylating its Ser127 and Ser381 residues. However, the events downstream of actin cytoskeletal changes that are involved in the regulation of the LATS–YAP pathway and the mechanism by which LATS differentially phosphorylates YAP on Ser127 and Ser381 in vivo have remained elusive. Here, we show that cyclic AMP (cAMP)-dependent protein kinase (PKA) phosphorylates LATS and thereby enhances its activity sufficiently to phosphorylate YAP on Ser381. We also found that PKA activity is involved in all contexts previously reported to trigger the LATS–YAP pathway, including actin cytoskeletal damage, G-protein-coupled receptor activation, and engagement of the Hippo pathway. Inhibition of PKA and overexpression of YAP cooperate to transform normal cells and amplify neural progenitor pools in developing chick embryos. We also implicate neurofibromin 2 as an AKAP (A-kinase-anchoring protein) scaffold protein that facilitates the function of the cAMP/PKA–LATS–YAP pathway. Our study thus incorporates PKA as novel component of the Hippo pathway. PMID:23644383

Fog at the Guarulhos International Airport from 1951 to 2015

Science.gov (United States)

França, Gutemberg Borges; do Carmo, Luiz Felipe Rodrigues; de Almeida, Manoel Valdonel; Albuquerque Neto, Francisco Leite

2018-02-01

This paper presents and discusses the fog occurrences before and after the construction of the Guarulhos International Airport, using data from 1951 to 2015. The analysis showed the following: (1) a total of 19,816 h of fog were registered. (2) The minimum average, mean and maximum average of the fog temperature had significantly increased after the airport was constructed from 1.2 to 6.9, 12.1 to 14.5 and 20.2 to 20.7 °C, respectively, due to the urban development around the airport during the study period. (3) The average fog hours per year decreased by approximately 73.1%, i.e., from 492 ± 84.45 to 132 ± 54.51 h per year. (4) Most of the fog events occurred due to longwave cooling on clear nights with relatively low wind speeds (characterizing radiation fog), with over 65% having duration of 2 h and occurring in the early hours of the day during March-September period. (5) The maximum probability of fog occurrence dropped about 10% from before to after the construction of the airport. Finally, two fog events are investigated using data collected during the fog evolution using atmospheric sounding profiles (from an acoustic sounder) and automatic meteorological stations and preliminary results showed that the values of cooling rate and turbulent kinetic energy play key roles in the onset and growth-dissipation phases of the fog, respectively.

Screening for Influenza A(H1N1)pdm09, Auckland International Airport, New Zealand

Science.gov (United States)

Hale, Michael J.; Baker, Michael G.

2012-01-01

Entry screening for influenza A(H1N1)pdm09 at Auckland International Airport, New Zealand, detected 4 cases, which were later confirmed, among 456,518 passengers arriving April 27–June 22, 2009. On the basis of national influenza surveillance data, which suggest that ≈69 infected travelers passed through the airport, sensitivity for screening was only 5.8%. PMID:22516105

Interacting forms of expertise in security governance: the example of CCTV surveillance at Geneva International Airport.

Science.gov (United States)

Klauser, Francisco

2009-06-01

The paper investigates the multiple public-private exchanges and cooperation involved in the installation and development of CCTV surveillance at Geneva International Airport. Emphasis is placed on the interacting forms of authority and expertise of five parties: the user(s), owner and supplier of the camera system, as well as the technical managers of the airport and the Swiss regulatory bodies in airport security. While placing the issues of airport surveillance in the particular context of a specific range of projects and transformations relating to the developments of CCTV at Geneva Airport, the paper not only provides important insights into the micro-politics of surveillance at Geneva Airport, but aims to re-institute these as part of a broader 'problematic': the mediating role of expertise and the growing functional fragmentation of authority in contemporary security governance. On this basis, the paper also exemplifies the growing mutual interdependences between security and business interests in the ever growing 'surveillant assemblage' in contemporary security governance.

Sources of sub-micrometre particles near a major international airport

Science.gov (United States)

Masiol, Mauro; Harrison, Roy M.; Vu, Tuan V.; Beddows, David C. S.

2017-10-01

The international airport of Heathrow is a major source of nitrogen oxides, but its contribution to the levels of sub-micrometre particles is unknown and is the objective of this study. Two sampling campaigns were carried out during warm and cold seasons at a site close to the airfield (1.2 km). Size spectra were largely dominated by ultrafine particles: nucleation particles ( strategies are applied successfully.

Study of carbon dioxide emission inventory from transportation sector at Kualanamu International Airport

Science.gov (United States)

Suryati, I.; Indrawan, I.; Alihta, K. N.

2018-02-01

Transportation includes sources of greenhouse gas emission contributor in the form of carbon dioxide (CO2). CO2 is one of the air pollutant gases that cause climate change. The source of CO2 emissions at airports comes from road and air transportation. Kualanamu International Airport is one of the public service airports in North Sumatera Province. The purpose of this study is to inventory the emission loads generated by motor vehicles and aircraft and to forecast contributions of CO2 emissions from motor vehicles and aircraft. The research method used is quantitative and qualitative methods. The quantitative method used is to estimate emission loads of motor vehicles based on vehicle volume and emission factors derived from the literature and using the Tier-2 method to calculate the aircraft emission loads. The results for the maximum CO2 concentration were 6,206,789.37 μg/m3 and the minimal CO2 concentration was 4,070,674.84 μg/Nm3. The highest aircraft CO2 emission load is 200,164,424.5 kg/hr (1.75 x 109 ton/year) and the lowest is 38,884,064.5 kg/hr (3.40 x 108 ton/year). Meanwhile, the highest CO2 emission load from motor vehicles was 51,299.25 gr/hr (449,38 ton/year) and the lowest was 38,990.42 gr/hr (341,55 ton/year). CO2 contribution from a motor vehicle is 65% and 5% from aircraft in Kualanamu International Airport.

Air pollution simulation and geographical information systems (GIS) applied to Athens International Airport.

Science.gov (United States)

Theophanides, Mike; Anastassopoulou, Jane

2009-07-01

This study presents an improved methodology for analysing atmospheric pollution around airports using Gaussian-plume numerical simulation integrated with Geographical Information Systems (GIS). The new methodology focuses on streamlining the lengthy analysis process for Airport Environmental Impact Assessments by integrating the definition of emission sources, simulating and displaying the results in a GIS environment. One of the objectives of the research is to validate the methodology applied to the Athens International Airport, "Eleftherios Venizelos", to produce a realistic estimate of emission inventories, dispersion simulations and comparison to measured data. The methodology used a combination of the Emission Dispersion and Modelling System (EDMS) and the Atmospheric Dispersion and Modelling system (ADMS) to improve the analysis process. The second objective is to conduct numerical simulations under various adverse conditions (e.g. scenarios) and assess the dispersion in the surrounding areas. The study concludes that the use of GIS in environmental assessments provides a valuable advantage for organizing data and entering accurate geographical/topological information for the simulation engine. Emissions simulation produced estimates within 10% of published values. Dispersion simulations indicate that airport pollution will affect neighbouring cities such as Rafina and Loutsa. Presently, there are no measured controls in these areas. In some cases, airport pollution can contribute to as much as 40% of permissible EU levels in VOCs.

78 FR 38069 - Expansion of Global Entry to Additional Airports

Science.gov (United States)

2013-06-25

... Airport, Dallas, Texas (DFW); Honolulu International Airport, Honolulu, Hawaii (HNL); Boston--Logan... private aircraft terminal; Minneapolis-St. Paul International Airport, Minneapolis, Minnesota (MSP...

Heavy Metal Pollution Around International Hatay Airport

Directory of Open Access Journals (Sweden)

Abdullah Özkan

2017-02-01

Full Text Available In this study, it was aimed to determine the heavy metal pollution in the agricultural lands around Hatay airport and travel possible alteration in the amount of heavy metal on the land in accordance with the distance to the airport. For this purpose, the airport was chosen as the center and 27 soil samples were obtained around the airport at 2 km intervals in depth ranging from 0 to 30 cm. Lead (Pb, cadmium (Cd, nickel (Ni, chrome (Cr, cobalt (Co, aluminium (Al, iron (Fe, copper (Cu, manganese (Mn and zinc (Zn elements in soil samples were analysed using MP-AES instrument by DTPA method. (3 repetition for each sample. As a result of the analysis, heavy metal concentrations were found as Pb 0-1.45 mg/kg, Cd 0-0.220 mg/kg, Ni 0-3.95 mg/kg, Cr 0-0.780 mg/kg, Co 0-0.270 mg/kg, Al 0-0.700 mg/kg, Fe 1.47- 16.2 mg/kg, Cu 0.400-5.35 mg/kg, Mn 0-19 mg/kg and Zn 0.050-3.14 mg/kg. When comparing the obtained data through this study with allowable concentrations of heavy metals in soil of Environment and Forest Directorates Guidance, it was determined that the heavy metal concentration of the soil does not pose any problems in terms of heavy metal pollution. Besides, iron concentration was decreased when the distance to the airport is increased.

YAP regulates neuronal differentiation through Sonic hedgehog signaling pathway

International Nuclear Information System (INIS)

Lin, Yi-Ting; Ding, Jing-Ya; Li, Ming-Yang; Yeh, Tien-Shun; Wang, Tsu-Wei; Yu, Jenn-Yah

2012-01-01

Tight regulation of cell numbers by controlling cell proliferation and apoptosis is important during development. Recently, the Hippo pathway has been shown to regulate tissue growth and organ size in Drosophila. In mammalian cells, it also affects cell proliferation and differentiation in various tissues, including the nervous system. Interplay of several signaling cascades, such as Notch, Wnt, and Sonic Hedgehog (Shh) pathways, control cell proliferation during neuronal differentiation. However, it remains unclear whether the Hippo pathway coordinates with other signaling cascades in regulating neuronal differentiation. Here, we used P19 cells, a mouse embryonic carcinoma cell line, as a model to study roles of YAP, a core component of the Hippo pathway, in neuronal differentiation. P19 cells can be induced to differentiate into neurons by expressing a neural bHLH transcription factor gene Ascl1. Our results showed that YAP promoted cell proliferation and inhibited neuronal differentiation. Expression of Yap activated Shh but not Wnt or Notch signaling activity during neuronal differentiation. Furthermore, expression of Yap increased the expression of Patched homolog 1 (Ptch1), a downstream target of the Shh signaling. Knockdown of Gli2, a transcription factor of the Shh pathway, promoted neuronal differentiation even when Yap was over-expressed. We further demonstrated that over-expression of Yap inhibited neuronal differentiation in primary mouse cortical progenitors and Gli2 knockdown rescued the differentiation defect in Yap over-expressing cells. In conclusion, our study reveals that Shh signaling acts downstream of YAP in regulating neuronal differentiation. -- Highlights: ► YAP promotes cell proliferation and inhibits neuronal differentiation in P19 cells. ► YAP promotes Sonic hedgehog signaling activity during neuronal differentiation. ► Knockdown of Gli2 rescues the Yap-overexpression phenotype in P19 cells. ► Knockdown of Gli2 rescues the Yap

YAP regulates neuronal differentiation through Sonic hedgehog signaling pathway

Energy Technology Data Exchange (ETDEWEB)

Lin, Yi-Ting; Ding, Jing-Ya [Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112, Taiwan (China); Li, Ming-Yang [Department of Life Science, National Taiwan Normal University, Taipei 116, Taiwan (China); Yeh, Tien-Shun [Department of Anatomy and Cell Biology, National Yang-Ming University, Taipei 112, Taiwan (China); Wang, Tsu-Wei [Department of Life Science, National Taiwan Normal University, Taipei 116, Taiwan (China); Yu, Jenn-Yah [Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112, Taiwan (China); Brain Research Center, National Yang-Ming University, Taipei 112, Taiwan (China)

2012-09-10

Tight regulation of cell numbers by controlling cell proliferation and apoptosis is important during development. Recently, the Hippo pathway has been shown to regulate tissue growth and organ size in Drosophila. In mammalian cells, it also affects cell proliferation and differentiation in various tissues, including the nervous system. Interplay of several signaling cascades, such as Notch, Wnt, and Sonic Hedgehog (Shh) pathways, control cell proliferation during neuronal differentiation. However, it remains unclear whether the Hippo pathway coordinates with other signaling cascades in regulating neuronal differentiation. Here, we used P19 cells, a mouse embryonic carcinoma cell line, as a model to study roles of YAP, a core component of the Hippo pathway, in neuronal differentiation. P19 cells can be induced to differentiate into neurons by expressing a neural bHLH transcription factor gene Ascl1. Our results showed that YAP promoted cell proliferation and inhibited neuronal differentiation. Expression of Yap activated Shh but not Wnt or Notch signaling activity during neuronal differentiation. Furthermore, expression of Yap increased the expression of Patched homolog 1 (Ptch1), a downstream target of the Shh signaling. Knockdown of Gli2, a transcription factor of the Shh pathway, promoted neuronal differentiation even when Yap was over-expressed. We further demonstrated that over-expression of Yap inhibited neuronal differentiation in primary mouse cortical progenitors and Gli2 knockdown rescued the differentiation defect in Yap over-expressing cells. In conclusion, our study reveals that Shh signaling acts downstream of YAP in regulating neuronal differentiation. -- Highlights: Black-Right-Pointing-Pointer YAP promotes cell proliferation and inhibits neuronal differentiation in P19 cells. Black-Right-Pointing-Pointer YAP promotes Sonic hedgehog signaling activity during neuronal differentiation. Black-Right-Pointing-Pointer Knockdown of Gli2 rescues the Yap

Analysis of Ground-Wind Vortex Sensing System Data from O'Hare International Airport

Science.gov (United States)

1980-09-01

From July 1976 through September 1977, aircraft wake vortex data were collected on the approach to runways 14R, 27R, and 32L at O'Hare International Airport. The vortices from over 21,000 aircraft were tracked using the propeller anemometer Ground-Wi...

THE EFFECT OF SERVICE QUALITY IN INTERNATIONAL AIRPORT I GUSTI NGURAH RAI ON SATISFACTION, IMAGE, AND TOURISTS LOYALTY WHO VISITED BALI

Directory of Open Access Journals (Sweden)

Saroha Manulang

2016-03-01

Full Text Available Airport are the first and the last contact point for tourists when they arrive at their holiday destination. Therefore, the airport facilities are a source of first impression that effect the quality expectations of the tourists on holiday activities. Bali as a world class tourism destination to develop and renovate the Ngurah Rai International Airport in order to improve quality of service in order to give higher satisfaction for tourists visiting Bali. Based on this study aims to determine (1 the effect of quality of service to tourists' satisfaction and the image of Bali tourism; (2 the effect of the image of tourism and the quality of service to the loyalty of tourists visiting Bali; (3 the effect of the satisfaction of tourists to the tourism image and loyalty of tourists visiting Bali; (4 the effect of indirect tourism image of the traveler loyalty through satisfaction of tourists; (5 service quality indirectly traveler loyalty through tourism image; and (6 to determine the rating opinion on the quality of service Bali's Ngurah Rai International Airport. Population of this research was all foreign tourists visiting Bali through Ngurah Rai Airport at the time of the research. The research samples included 348 respondents were chosen with nonprobability sampling. accidental sampling technique. Data collected through questionnaires, interviews and observations. The collected data were analyzed with SERVQUAL, Importance Performance Analysis (IPA, and Structural Equation Modelling (SEM for hypothesis testing. The results showed (1 the quality of service Bali's Ngurah Rai International Airport is a positive effect on tourist satisfaction and the image of Bali tourism; (2 the image of tourism and service quality Bali's Ngurah Rai International Airport is a positive effect on loyalty rating; (3 The traveler satisfaction positive effect on tourism image and loyalty of tourists visiting Bali; (4 Tourism image positive effect on loyalty through

Approaches towards airport economic performance measurement

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Ivana STRYČEKOVÁ

2011-01-01

Full Text Available The paper aims to assess how economic benchmarking is being used by airports as a means of performance measurement and comparison of major international airports in the world. The study focuses on current benchmarking practices and methods by taking into account different factors according to which it is efficient to benchmark airports performance. As methods are considered mainly data envelopment analysis and stochastic frontier analysis. Apart from them other approaches are discussed by airports to provide economic benchmarking. The main objective of this article is to evaluate the efficiency of the airports and answer some undetermined questions involving economic benchmarking of the airports.

A Benchmarking of Operational Efficiency in Asia Pacific International Cargo Airports

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Tae-won Chung

2015-03-01

Full Text Available This paper compares operational efficiency of major cargo airports in the Asia Pacific region. The multi-dimensional scaling cluster analysis by R-square method was used as the benchmarking tool to provide airport management with a means to examine various aspects of their operational efficiency against those of other airports. Ten operational efficiency factors for the clustering and efficiency estimation of airports in the Asia Pacific region were used in a regression model to overcome the complexity of multi-dimensional scaling approach. The resulting classification is used to identify the efficiency benchmarks of leading air cargo airports which have implications for Incheon airport in Korea.

The Development of Jomo Kenyatta International Airport as a Regional Aviation Hub

Science.gov (United States)

Irandu, Evaristus M.; Rhoades, Dawna L.

2006-01-01

Air transportation plays an important role in the social and economic development of the global system and the countries that seek to participate in it. As Africa seeks to take its place in the global economy, it is increasingly looking to aviation as the primary means of connecting its people and goods with the world. It has been suggested that Africa as a continent needs to move toward a system of hubs to optimize its scarce resources. Jomo Kenyatta International Airport in Nairobi, Kenya, is one of the airports in the eastern region of Africa that is seeking to fill this role. This paper discusses the prospects for success and the challenges that it will need to overcome, including projections through 2020 for the growth in passenger and cargo traffic.

77 FR 58208 - Airport Privatization Pilot Program

Science.gov (United States)

2012-09-19

... Privatization Pilot Program AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of receipt of... International Airport, San Juan, Puerto Rico (SJU) in the Airport Privatization Pilot Program and has determined....S.C. Section 47134 establishes an airport privatization pilot program and authorizes the Department...

First report on invasion of yellow fever mosquito, Aedes aegypti, at Narita International Airport, Japan in August 2012.

Science.gov (United States)

Sukehiro, Nayu; Kida, Nori; Umezawa, Masahiro; Murakami, Takayuki; Arai, Naoko; Jinnai, Tsunesada; Inagaki, Shunichi; Tsuchiya, Hidetoshi; Maruyama, Hiroshi; Tsuda, Yoshio

2013-01-01

The invasion of the yellow fever mosquito Aedes aegypti at Narita International Airport, Japan was detected for the first time. During the course of routine vector surveillance at Narita International Airport, 27 Ae. aegypti adults emerged from larvae and pupae collected from a single larvitrap placed near No. 88 spot at passenger terminal 2 on August 8, 2012. After the appearance of Ae. aegypti in the larvitrap, we defined a 400-m buffer zone and started an intensive vector survey using an additional 34 larvitraps and 15 CO2 traps. International aircraft and passenger terminal 2 were also inspected, and one Ae. aegypti male was collected from the cargo space of an international aircraft from Darwin via Manila on August 28, 2012. Larvicide treatment with 1.5% fenitrothion was conducted in 64 catch basins and one ditch in the 400-m buffer zone. Twenty-four large water tanks were also treated at least once with 0.5% pyriproxyfen, an insect growth regulator. No Ae. aegypti eggs or adults were found during the 1-month intensive vector survey after finding larvae and pupae in the larvitrap. We concluded that Ae. aegypti had failed to establish a population at Narita International Airport.

An Analysis of Delay and Travel Times at Sao Paulo International Airport (AISP/GRU): Planning Based on Simulation Model

Science.gov (United States)

Santana, Erico Soriano Martins; Mueller, Carlos

2003-01-01

The occurrence of flight delays in Brazil, mostly verified at the ground (airfield), is responsible for serious disruptions at the airport level but also for the unchaining of problems in all the airport system, affecting also the airspace. The present study develops an analysis of delay and travel times at Sao Paulo International Airport/ Guarulhos (AISP/GRU) airfield based on simulation model. Different airport physical and operational scenarios had been analyzed by means of simulation. SIMMOD Plus 4.0, the computational tool developed to represent aircraft operation in the airspace and airside of airports, was used to perform these analysis. The study was mainly focused on aircraft operations on ground, at the airport runway, taxi-lanes and aprons. The visualization of the operations with increasing demand facilitated the analyses. The results generated in this work certify the viability of the methodology, they also indicated the solutions capable to solve the delay problem by travel time analysis, thus diminishing the costs for users mainly airport authority. It also indicated alternatives for airport operations, assisting the decision-making process and in the appropriate timing of the proposed changes in the existing infrastructure.

78 FR 79061 - Noise Exposure Map Notice; Key West International Airport, Key West, FL

Science.gov (United States)

2013-12-27

... INFORMATION CONTACT: Allan Nagy, Federal Aviation Administration, Orlando Airports District Office, 5950 Hazeltine National Drive Citadel International Building, Suite 400, Orlando, FL 32822, 407-812-6331... Maps which meet applicable regulations and which depict non-compatible land uses as of the date of...

The Evaluation of Factors Influencing Flights Delay at Czech International Airports

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Martina Zámková

2015-01-01

Full Text Available The main goal of this article was examination of factors influencing flights delay at three most important international airports in Czech Republic. Data of selected Airlines operating in Czech Republic, whose flights are mainly oriented to international airports in Prague, Brno and Ostrava, were used for needs of this article. Analysis of contingency tables including Pearson chi-squared test was used for data processing. Dependences were presented in graphical form by correspondence analysis. Results from analysis showed that delay caused by technical reasons and maintenance is the most frequent in Prague as well as delay caused by high concentration of airspace, operational management and crew duty norms. Problems caused by departure delay from previous destination are significantly more frequent in Brno and Ostrava by reason of small number of alternative available aircraft. Delays caused by supplier (handling, catering, … are mostly short, in particular by reason of potential penalty. Delays caused by technical problems and necessary maintenance service last mostly longer time and are more frequently on aircraft of type Boeing. Delays of borrowed aircraft of type Airbus are more frequently caused by rental and control of this aircraft by other companies which causes communication and planning difficulties.

Yes-Associated Protein (YAP) Promotes the Nuclear Import of p73

International Nuclear Information System (INIS)

Zhang Heng; Wu Shengnan

2011-01-01

p73 has been identified as a structural and functional homolog of the tumor suppressor p53. However, mechanisms that regulate the localization of p73 have not been fully clarified. The Yes-associated protein (YAP) is a transcriptional coactivator. As a transcriptional coactivator, YAP needs to bind transcription factors to stimulate gene expression. p73 is a reported YAP target transcription factors and YAP has been shown to positively regulate p73 in promoting apoptosis. Previous studies show that p73 interacts with YAP through its PPPY motif, and increases p73 transactivation of apoptotic genes. In this study, we focused on YAP's regulation of the localization of p73. After transient transfection into Rat pheochromocytoma (PC12) cells and Human embryonic kidney 293T cells with GFP-YAP and/or YFP-p73, and incubated for 24 hours expression. p73 was fused to YFP to allow the examination of its subcellular localization. When expressed alone, YFP-p73 was distributed throughout the cell. When coexpressed with YAP, nuclear accumulation of YFP-p73 became evident. We quantitated the effect of YAP on the redistribution of YFP-p73 by counting cells with nuclear-only YFP signal. We found that YAP can influence the subcellular distribution of p73. Altogether, coexpression with YAP affected the subcellular distribution of the p73 protein. Our studies attribute a central role to YAP in regulating p73 accumulation and YAP, at least in part, might promote the nuclear import of p73.

Development of Airport Noise Mapping using Matlab Software (Case Study: Adi Soemarmo Airport - Boyolali, Indonesia)

Science.gov (United States)

Andarani, Pertiwi; Setiyo Huboyo, Haryono; Setyanti, Diny; Budiawan, Wiwik

2018-02-01

Noise is considered as one of the main environmental impact of Adi Soemarmo International Airport (ASIA), the second largest airport in Central Java Province, Indonesia. In order to manage the noise of airport, airport noise mapping is necessary. However, a model that requires simple input but still reliable was not available in ASIA. Therefore, the objective of this study are to develop model using Matlab software, to verify its reliability by measuring actual noise exposure, and to analyze the area of noise levels‥ The model was developed based on interpolation or extrapolation of identified Noise-Power-Distance (NPD) data. In accordance with Indonesian Government Ordinance No.40/2012, the noise metric used is WECPNL (Weighted Equivalent Continuous Perceived Noise Level). Based on this model simulation, there are residence area in the region of noise level II (1.912 km2) and III (1.16 km2) and 18 school buildings in the area of noise levels I, II, and III. These land-uses are actually prohibited unless noise insulation is equipped. The model using Matlab in the case of Adi Soemarmo International Airport is valid based on comparison of the field measurement (6 sampling points). However, it is important to validate the model again once the case study (the airport) is changed.

Evolution and virulence contributions of the autotransporter proteins YapJ and YapK of Yersinia pestis CO92 and their homologs in Y. pseudotuberculosis IP32953.

Science.gov (United States)

Lenz, Jonathan D; Temple, Brenda R S; Miller, Virginia L

2012-10-01

Yersinia pestis, the causative agent of plague, evolved from the gastrointestinal pathogen Yersinia pseudotuberculosis. Both species have numerous type Va autotransporters, most of which appear to be highly conserved. In Y. pestis CO92, the autotransporter genes yapK and yapJ share a high level of sequence identity. By comparing yapK and yapJ to three homologous genes in Y. pseudotuberculosis IP32953 (YPTB0365, YPTB3285, and YPTB3286), we show that yapK is conserved in Y. pseudotuberculosis, while yapJ is unique to Y. pestis. All of these autotransporters exhibit >96% identity in the C terminus of the protein and identities ranging from 58 to 72% in their N termini. By extending this analysis to include homologous sequences from numerous Y. pestis and Y. pseudotuberculosis strains, we determined that these autotransporters cluster into a YapK (YPTB3285) class and a YapJ (YPTB3286) class. The YPTB3286-like gene of most Y. pestis strains appears to be inactivated, perhaps in favor of maintaining yapJ. Since autotransporters are important for virulence in many bacterial pathogens, including Y. pestis, any change in autotransporter content should be considered for its impact on virulence. Using established mouse models of Y. pestis infection, we demonstrated that despite the high level of sequence identity, yapK is distinct from yapJ in its contribution to disseminated Y. pestis infection. In addition, a mutant lacking both of these genes exhibits an additive attenuation, suggesting nonredundant roles for yapJ and yapK in systemic Y. pestis infection. However, the deletion of the homologous genes in Y. pseudotuberculosis does not seem to impact the virulence of this organism in orogastric or systemic infection models.

Service quality improvement of ground staff at Don Mueang International Airport

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Sittichai Sricharoenpramong

2018-01-01

Full Text Available The purposes of this research were to: 1 evaluate the service quality of the ground staff at Don Mueang International Airport (DMK, 2 compare the ground staff quality service perception of Thai passengers at DMK, and 3 provide guidelines for service quality improvement of the DMK airlines ground staff. A sample size of 400 Thai domestic passengers was accidentally selected at DMK. A questionnaire was used as a research tool for data collection. Five dimensions of service quality were evaluated: reliability, responsiveness, assurance, empathy, and tangibles. It was found that the service quality of ground staff was moderate. The highest dimension of service quality realization was tangibles, followed successively by reliability, assurance, empathy, and responsiveness. The passengers' perception of the ground staff's service quality varied by gender and age group. Guidelines were proposed for the improvement of ground staff service quality at DMK based on the findings. Keywords: airport, ground staff, quality of service

Customer experiences and return patronage in airport hotels: Evidence from OR Tambo International Airport, South Africa

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Oswald Mhlanga

2018-05-01

Contribution/value-add: To the best of the researchers’ knowledge, this study is a first attempt to determine customer experiences and return patronage in hotels at or near airports in South Africa. The results could help airport hotels to gain a competitive advantage over other hotel categories.

75 FR 9017 - Orders Limiting Scheduled Operations at John F. Kennedy International Airport, LaGuardia Airport...

Science.gov (United States)

2010-02-26

... disruption and cancellations varied by airport and by day, but DCA, JFK, LGA, and EWR all were affected by the storms. However, the flight disruptions were not limited to the slot-controlled airports... cancellations. These rules are expected to accommodate routine weather and other cancellations under all but the...

Opportunity of Constructing a Cargo Terminal – Case Study Brașov International Airport, Romania

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Gabriel BRĂTUCU

2017-02-01

Full Text Available Air transport and especially air cargo transport became ever more important during the last 25 years, with a signifi cant impact upon economic development. Air cargo transport supports regional economic development, provided there is suffi cient local demand for its services. In our study, we have identifi ed signifi cant elements of the impact a cargo terminal at the International Brașov-Ghimbav Airport would have upon local economic development. For this purpose, we have conducted a quantitative market research. We have reached the conclusion that constructing a cargo terminal at the Brașov-Ghimbav Airport is a necessary investment in the current economic context, with an important contribution to the economic development of its surrounding counties. The positive results registered in our study could contribute to improving the economic and fi nancial prospects of Brașov-Ghimbav Airport and attract investors in this project.

75 FR 57106 - Public Notice for Sale of Airport Property at Houlton International Airport, Houlton, ME

Science.gov (United States)

2010-09-17

.... Ford Aviation Investment and Reform Act for the 21st Century (AIR 21) requires the FAA to provide an... obligation to use certain airport property for aeronautical purposes. The revenue generated from the disposal... Airport Revenue, published in the Federal Register on February 16, 1999. DATES: Comments must be received...

Occupational noise-induced hearing loss among workers at Jomo Kenyatta International Airport, Nairobi.

Science.gov (United States)

Anino, J O; Afullo, A; Otieno, F

2010-02-01

Occupational noise induced hearing loss (NIHL) occurs among workers exposed to excessive amounts of noise for long durations. The average level of noise in some locations at Jomo Kenyatta International Airport (JKIA) was above the safe limit of 85dB hence workers were thought to be at risk. To determine the occurrence and socio demographic attributes for NIHL at JKIA. Cross sectional descriptive study. Jomo Kenyatta International Airport, Nairobi, Kenya. Mean age of respondents was 37 years with range 22 to 62, SD 8.98. Mean duration of exposure to noise was 10.7 years with range 1 to 40, SD 8.15. Prevalence of NIHL was 15.3%, with ground crew at 14.8% and air crew 16.1%. Ground crew had significantly poorer mean hearing threshold level at 3, 4 and 6 kHz than air crew (p = 0.015). Male workers were affected more than female counterparts with a male to female ratio of 4:3. 97% of those affected were non-managers, 3% managers while 68% of those affected resided in Embakasi Division close to the airport. Hearing threshold level at 4 kHz deteriorated with increasing age whereby those aged 50 years and above had a 13.7 times higher relative risk than those aged 20 to 29 years. Duration of exposure more than 10 years also had significantly higher risk (p hearing loss at 4 kHz. Occupational noise induced hearing loss occurs atJKIA and that ground crew and older workers are more vulnerable. We recommend that prevention programmes be put in place.

GATEWAY Demonstrations: Philadelphia International Airport Apron Lighting: LED System Performance in a Trial Installation

Energy Technology Data Exchange (ETDEWEB)

Davis, Robert G. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Wilkerson, Andrea M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

2015-10-30

This report documents a trial installation of LED apron lighting that replaced the existing high-pressure sodium luminaires at Philadelphia International Airport. Such high-mast applications remain challenging for LED technology, and the lessons learned from this project may help facility managers and LED product manufacturers better meet those challenges.

Analysis of efficiency of the Brazilian international airports

Directory of Open Access Journals (Sweden)

Marina Rodriguez Brochado

2008-07-01

Brazil. Analysis of correlations was used to select the 0 variable most representative of this system and after that, it was calculated efficiency of the system for classic and inverted the borders by means of model BCC guided for output. Finally, it was possible to identify which improvements are necessary for the inefficient airports, in way to identify which improvements are necessary to operational level to reach the efficiency. Key-words: Data Envelopment Analysis, Efficiency, Airports.

Investigating the effects of sales promotions on customer behavioral intentions at duty-free shops: An Incheon International Airport case study

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Jin-Woo Park

2013-09-01

Full Text Available Purpose: This paper seeks to investigate the effects of sales promotions at airport duty-free shops by testing a conceptual model that considers price, coupons, free gifts, points, satisfaction, value, image, and behavioral intentions simultaneously.Design/methodology/approach: For this testing, structural equation modeling was applied to data collected from duty-free shop users at Incheon International Airport.Findings: Price and coupons were found as significant drivers of customer satisfaction, which was directly related to customer value, image, and behavioral intentions.Originality/value: This paper is the first research that examines the effects of sales promotions at the duty-free shops of Incheon International Airport. The identified sales promotion factors that influence the behavioral intentions of customers at duty-free shops are potentially useful for analyzing the possible trends and changes in duty-free shop customer buying behavior.

Los Angeles International Airport Runway Incursion Studies: Phase III--Center-Taxiway Simulation

Science.gov (United States)

Madson, Michael D.

2004-01-01

Phase III of the Los Angeles International Airport Runway Incursion Studies was conducted, under an agreement with HNTB Corporation, at the NASA Ames FutureFlight Central (FFC) facility in June 2003. The objective of the study was the evaluation of a new center-taxiway concept at LAX. This study is an extension of the Phase I and Phase II studies previously conducted at FFC. This report presents results from Phase III of the study, in which a center-taxiway concept between runways 25L and 25R was simulated and evaluated. Phase III data were compared objectively against the Baseline data. Subjective evaluations by participating LAX controllers were obtained with regard to workload, efficiency, and safety criteria. To facilitate a valid comparison between Baseline and Phase III data, the same scenarios were used for Phase III that were tested during Phases I and II. This required briefing participating controllers on differences in airport and airline operations between 2001 and today.

Economic impact studies on development project of New Yogyakarta International Airport to aquaculture in Kulonprogo Coastal

Science.gov (United States)

Rachman, F.; Satriagasa, M. C.; Riasasi, W.

2018-03-01

New Yogyakarta International Airport (NYIA) is being constructed in Temon Sub District, Kulonprogo District. It lies on 587.2 ha area in the southern part of Java Island coastal area. Many areas of Kulonprogro coastal area are used for aquaculture of vanname shrimp. In that case, the aquaculture land needs to be cleared for the airport construction necessity and requires compensation. The value of the compensation needs to be right calculated by both sides, regarding the aquaculture land are local community assets. This study uses spatial analysis and visual interpretation. Whereas, the calculation of the acquisition value and income capital value uses Discounted Cash Flow (DCF) method. The result shows the area of aquaculture land which impacted to be cleared is 83 ha, means decreasing of shrimp ponds area in Temon Sub District, Kulonprogo District. The calculation of acquisition value for airport development indicates higher value than the income from the aquaculture activity. The results mean the aquaculture landlords do not incur losses due to the airport development project. These findings can be used for local government and related stakeholders to formulate a policy of aquaculture relocation and to estimate projection for aquaculture land suitability in Yogyakarta coastal area.

Aspect Of Reliability In Airport Business Continuity Management

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Kozłowski Michał

2015-11-01

Full Text Available The paper presents the issue of ensuring the continuity of the operation at the airport. Requirements and objectives relating to business continuity management have been defined in accordance with ISO 22301 international standard. Conducted a study of reliability issues operation of the airport. Defined the function of the reliability and operational readiness of the airport. Presented the concept of using function of operational readiness in the risk assessment for the continuity of the airport.

Evaluation of Pushback Decision-Support Tool Concept for Charlotte Douglas International Airport Ramp Operations

Science.gov (United States)

Hayashi, Miwa; Hoang, Ty; Jung, Yoon C.; Malik, Waqar; Lee, Hanbong; Dulchinos, Victoria L.

2015-01-01

This paper proposes a new departure pushback decision-support tool (DST) for airport ramp-tower controllers. It is based on NASA's Spot and Runway Departure Advisor (SARDA) collaborative decision-making concept, except with the modification that the gate releases now are controlled by tactical pushback (or gate-hold) advisories instead of strategic pre-assignments of target pushback times to individual departure flights. The proposed ramp DST relies on data exchange with the airport traffic control tower (ATCT) to coordinate pushbacks with the ATCT's flow-management intentions under current operational constraints, such as Traffic Management Initiative constraints. Airlines would benefit in reduced taxi delay and fuel burn. The concept was evaluated in a human-in-the-loop simulation experiment with current ramp-tower controllers at the Charlotte Douglas International Airport as participants. The results showed that the tool helped reduce taxi time by one minute per flight and overall departure flight fuel consumption by 10-12% without reducing runway throughput. Expect Departure Clearance Time (EDCT) conformance also was improved when advisories were provided. These benefits were attained without increasing the ramp-tower controllers' workload. Additionally, the advisories reduced the ATCT controllers' workload.

The Effects of Chronic Exposure to Airport Related Noise on Blood Pressure (A Case Study of area nearby Ahmad Yani International Airport, Semarang

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Hani Afnita

2013-12-01

Full Text Available The chronic exposure of airport related noise can lead to decreased quality of health and is a risk faktor of disease. Noise can stimulate physiological response to cardiovascular parameters such as blood pressure. The increase in blood pressure can be used as indicator of disturbance of the cardiovascular system. Ahmad Yani Airport is an international airport with a high mobility, thus people living near, are susceptible and have a risk for decreased quality health. Thus, the purposes of this study was to determine the effects of chronic noise exposure of airport related noise on the blood pressure. The study was an observational analytic cross-sectional study. This research was conducted in the area near Ahmad Yani Airport in Semarang, which is located on Perumahan Cakarawala (± 1000m and Perumahan Semarang Indah (± 5000m. Total of 60 respondents were randomly included in the study. Noise is measured with a Sound Level Meter (SLM Extech Type 70 335 with Leq measurement method (Equivalent Continous Noise Level for 24 hours (Lsm. The preliminary questionnaire was distributed to fulfill the criteria of inclusion and exclusion. The blood pressures were evaluated using the mercury Spygmomanometer, before and after exposure (flight activity. Data were analyzed with dependent t test. Noise measurements indicated that the Perumahan Cakrawala II had ahigh noise exposure above the noise level standards (NAB of 69 dBA (Lsm > NAB 55dBA, while the Perumahan Semarang Indah has noise exposure at 51 dBA below the NAB. The results indicated that the chronic noise exposure of flight activity had significant effect on blood pressure (p = 0.00. The increase in blood pressure among Perumahan Cakrawala II respondents was higher (systolic: by 83.3%, diastolic: by 59.9% compared to Perumahan Semarang Indah (systolic: by 69.9%, diastolic : by 49,9%. In conclusion, exposure to chronic noise due to flight activity significantly affected blood pressure.

75 FR 3959 - Noise Exposure Map Notice for Kona International Airport at Keahole, Keahole, North Kona, HI

Science.gov (United States)

2010-01-25

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Noise Exposure Map Notice for Kona International Airport at Keahole, Keahole, North Kona, HI AGENCY: Federal Aviation Administration, DOT. ACTION: Notice. SUMMARY: The Federal Aviation Administration (FAA) announces its determination that the noise...

Dynamics of seizure of animal products in international baggage on Airport of Brasilia (AIB-PJK/SBBR.

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Cristiano Barros de Melo

2016-09-01

Full Text Available ABSTRACT. de Melo C.B., Fino T.C.M., Schwingel F.F., Santiago M.T., de Barros L.F.R., McManus C. & Sá M.E.P. [Dynamics of seizure of animal products in international baggage on Airport of Brasilia (AIB-PJK/SBBR.] Dinâmica da apreensão de produtos de origem animal em bagagens internacionais no Aeroporto de Brasília (AIB-PJK/SBBR. Revista Brasileira de Medicina Veterinária, 38(3:265-276, 2016. Universidade de Brasília, PPGCA, Campus Universitário Darcy Ribeiro, ICC Sul, Asa Norte, Brasília, DF 70910-900, Brasil. E-mail: cristianomelo@unb.br The risk of introducing infectious agents increases as the volume of imported products rises. The illegal entry of animal products (POA brought in international passenger baggage is a factor that makes up the risk assessment and that grows proportionally to the intensification of international transit passengers. They evaluated the data on seizures of animal products intercepted in international baggage passengers in Airport of Brasilia (AIB-PJK/SBBR between the years 2010 and 2012. The analysis of the dynamics of these seizures considered the POA category, origin, airline and months more frequently and also verified the correlation between these variables. According to retrospective analysis, nearly eight tons of POA were seized from 52 countries throughout the study period. The results showed Portugal (p <0.0001 as the source of passengers who had higher frequency and quantity of seizures, and, added to other European origins, totaled 84.3% of seizures. The months of July, August and September stood out for the highest number of seizures and greater movement of international passengers. The increase in the number of seizures accompanied by a rise in the percentage of inspected passengers (r=0.69, emphasizing the importance of airport surveillance. According to the calculation of relative risk, passengers from African and South American countries showed greater magnitude of risk to bring animal

YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression

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Julien Fitamant

2015-03-01

Full Text Available Defective Hippo/YAP signaling in the liver results in tissue overgrowth and development of hepatocellular carcinoma (HCC. Here, we uncover mechanisms of YAP-mediated hepatocyte reprogramming and HCC pathogenesis. YAP functions as a rheostat in maintaining metabolic specialization, differentiation, and quiescence within the hepatocyte compartment. Increased or decreased YAP activity reprograms subsets of hepatocytes to different fates associated with deregulation of the HNF4A, CTNNB1, and E2F transcriptional programs that control hepatocyte quiescence and differentiation. Importantly, treatment with small interfering RNA-lipid nanoparticles (siRNA-LNPs targeting YAP restores hepatocyte differentiation and causes pronounced tumor regression in a genetically engineered mouse HCC model. Furthermore, YAP targets are enriched in an aggressive human HCC subtype characterized by a proliferative signature and absence of CTNNB1 mutations. Thus, our work reveals Hippo signaling as a key regulator of the positional identity of hepatocytes, supports targeting of YAP using siRNA-LNPs as a paradigm of differentiation-based therapy, and identifies an HCC subtype that is potentially responsive to this approach.

Multi-objective Optimization of Departure Procedures at Gimpo International Airport

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Kim, Junghyun; Lim, Dongwook; Monteiro, Dylan Jonathan; Kirby, Michelle; Mavris, Dimitri

2018-04-01

Most aviation communities have increasing concerns about the environmental impacts, which are directly linked to health issues for local residents near the airport. In this study, the environmental impact of different departure procedures using the Aviation Environmental Design Tool (AEDT) was analyzed. First, actual operational data were compiled at Gimpo International Airport (March 20, 2017) from an open source. Two modifications were made in the AEDT to model the operational circumstances better and the preliminary AEDT simulations were performed according to the acquired operational procedures. Simulated noise results showed good agreements with noise measurement data at specific locations. Second, a multi-objective optimization of departure procedures was performed for the Boeing 737-800. Four design variables were selected and AEDT was linked to a variety of advanced design methods. The results showed that takeoff thrust had the greatest influence and it was found that fuel burn and noise had an inverse relationship. Two points representing each fuel burn and noise optimum on the Pareto front were parsed and run in AEDT to compare with the baseline. The results showed that the noise optimum case reduced Sound Exposure Level 80-dB noise exposure area by approximately 5% while the fuel burn optimum case reduced total fuel burn by 1% relative to the baseline for aircraft-level analysis.

The Hippo-YAP Pathway Regulates 3D Organ Formation and Homeostasis.

Science.gov (United States)

Ishihara, Erika; Nishina, Hiroshi

2018-04-17

The vertebrate body shape is formed by the specific sizes and shapes of its resident tissues and organs, whose alignments are essential for proper functioning. To maintain tissue and organ shape, and thereby function, it is necessary to remove senescent, transformed, and/or damaged cells, which impair function and can lead to tumorigenesis. However, the molecular mechanisms underlying three-dimensional (3D) organ formation and homeostasis are not fully clear. Yes-associated protein (YAP) is a transcriptional co-activator that is involved in organ size control and tumorigenesis. Recently, we reported that YAP is essential for proper 3D body shape through regulation of cell tension by using a unique medaka fish mutant, hirame ( hir ). In Madin–Darby canine kidney (MDCK) epithelial cells, active YAP-transformed cells are eliminated apically when surrounded by normal cells. Furthermore, in a mosaic mouse model, active YAP-expressing damaged hepatocytes undergo apoptosis and are eliminated from the liver. Thus, YAP functions in quantitative and quality control in organogenesis. In this review, we describe the various roles of YAP in vertebrates, including in the initiation of liver cancer.

Methodology of the Auditing Measures to Civil Airport Security and Protection

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Ján Kolesár

2016-10-01

Full Text Available Airports similarly to other companies are certified in compliance with the International Standardization Organization (ISO standards of products and services (series of ISO 9000 Standards regarding quality management, to coordinate the technical side of standardizatioon and normalization at an international scale. In order for the airports to meet the norms and the certification requirements as by the ISO they are liable to undergo strict audits of quality, as a rule, conducted by an independent auditing organization. Focus of the audits is primarily on airport operation economics and security. The article is an analysis into the methodology of the airport security audit processes and activities. Within the framework of planning, the sequence of steps is described in line with the principles and procedures of the Security Management System (SMS and starndards established by the International Standardization Organization (ISO. The methodology of conducting airport security audit is developed in compliance with the national programme and international legislation standards (Annex 17 applicable to protection of civil aviation against acts of unlawful interference.

Application of a pedestrian portal monitor at Madrid International Airport in Spain

Energy Technology Data Exchange (ETDEWEB)

Pujol, Ll., E-mail: luis.pujol@cedex.e [Centro de Estudios y Experimentacion de Obras Publicas (CEDEX), Alfonso XII, 3, 28014 Madrid (Spain); Univ Politecn Madrid (UPM), Dept Civil Engn Hydraul and Energet, ETSI Caminos, Profesor Aranguren, s/n, 28040 Madrid (Spain); Gonzalez-Gonzalez, J.A.; Suarez-Navarro, M.J. [Univ Politecn Madrid (UPM), Dept Civil Engn Hydraul and Energet, ETSI Caminos, Profesor Aranguren, s/n, 28040 Madrid (Spain)

2011-04-15

Three pedestrian portal monitor systems, designed to detect illicit trafficking or inadvertent movement of radioactive materials carried by passengers at airports, have been evaluated. The systems were supplied by three manufacturers: Bicron, Exploranium and Thermo-Eberline. In an initial evaluation, conducted at the Laboratory of Nuclear Engineering of the School of Civil Engineering, it was observed that the FHT-1372 system manufactured by Thermo-Eberline gave a more sensitive response and allowed the measurement of total photon dose rate and artificial photon dose rate. Therefore, this system was installed at Barajas International Airport in Madrid in 2002 for a period of 108 days in order to select an appropriate investigation level (defined as the radiation level that is selected as the trigger for further investigation). During this period 1,339,931 passengers were screened and a total of 39 alarms were triggered, 5 of which with a value 10 times the mean value of the natural background from photon radiation (which was 85 nSv/h), and no alarms exceeded 100 {mu}Sv/h at 1 m distance, which is the level of response for legal transport of radioactive materials set by the International Atomic Energy Agency (IAEA). An investigation level of approximately 1.3 times the natural background was finally selected. This value coincides with the results obtained in the ITRAP (Illicit Trafficking Radiation Detection Assessment Program) carried out by the IAEA.

Airport choice model in multiple airport regions

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Claudia Muñoz

2017-02-01

Full Text Available Purpose: This study aims to analyze travel choices made by air transportation users in multi airport regions because it is a crucial component when planning passenger redistribution policies. The purpose of this study is to find a utility function which makes it possible to know the variables that influence users’ choice of the airports on routes to the main cities in the Colombian territory. Design/methodology/approach: This research generates a Multinomial Logit Model (MNL, which is based on the theory of maximizing utility, and it is based on the data obtained on revealed and stated preference surveys applied to users who reside in the metropolitan area of Aburrá Valley (Colombia. This zone is the only one in the Colombian territory which has two neighboring airports for domestic flights. The airports included in the modeling process were Enrique Olaya Herrera (EOH Airport and José María Córdova (JMC Airport. Several structure models were tested, and the MNL proved to be the most significant revealing the common variables that affect passenger airport choice include the airfare, the price to travel the airport, and the time to get to the airport. Findings and Originality/value: The airport choice model which was calibrated corresponds to a valid powerful tool used to calculate the probability of each analyzed airport of being chosen for domestic flights in the Colombian territory. This is done bearing in mind specific characteristic of each of the attributes contained in the utility function. In addition, these probabilities will be used to calculate future market shares of the two airports considered in this study, and this will be done generating a support tool for airport and airline marketing policies.

Sources of sub-micrometre particles near a major international airport

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M. Masiol

2017-10-01

Full Text Available The international airport of Heathrow is a major source of nitrogen oxides, but its contribution to the levels of sub-micrometre particles is unknown and is the objective of this study. Two sampling campaigns were carried out during warm and cold seasons at a site close to the airfield (1.2 km. Size spectra were largely dominated by ultrafine particles: nucleation particles ( < 30 nm were found to be  ∼ 10 times higher than those commonly measured in urban background environments of London. Five clusters and six factors were identified by applying k means cluster analysis and positive matrix factorisation (PMF, respectively, to particle number size distributions; their interpretation was based on their modal structures, wind directionality, diurnal patterns, road and airport traffic volumes, and on the relationship with weather and other air pollutants. Airport emissions, fresh and aged road traffic, urban accumulation mode, and two secondary sources were then identified and apportioned. The fingerprint of Heathrow has a characteristic modal structure peaking at  < 20 nm and accounts for 30–35 % of total particles in both the seasons. Other main contributors are fresh (24–36 % and aged (16–21 % road traffic emissions and urban accumulation from London (around 10 %. Secondary sources accounted for less than 6 % in number concentrations but for more than 50 % in volume concentration. The analysis of a strong regional nucleation event showed that both the cluster categorisation and PMF contributions were affected during the first 6 h of the event. In 2016, the UK government provisionally approved the construction of a third runway; therefore the direct and indirect impact of Heathrow on local air quality is expected to increase unless mitigation strategies are applied successfully.

Yap is required for ependymal integrity and is suppressed in LPA-induced hydrocephalus

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Park, Raehee; Moon, Uk Yeol; Park, Jun Young; Hughes, Lucinda J.; Johnson, Randy L.; Cho, Seo-Hee; Kim, Seonhee

2016-01-01

Timely generation and normal maturation of ependymal cells along the aqueduct are critical for preventing physical blockage between the third and fourth ventricles and the development of fetal non-communicating hydrocephalus. Our study identifies Yap, the downstream effector of the evolutionarily conserved Hippo pathway, as a central regulator for generating developmentally controlled ependymal cells along the ventricular lining of the aqueduct. Yap function is necessary for proper proliferation of progenitors and apical attachment of ependymal precursor cells. Importantly, an injury signal initiated by lysophosphatidic acid (LPA), an upstream regulator of Yap that can cause fetal haemorrhagic hydrocephalus, deregulates Yap in the developing aqueduct. LPA exposure leads to the loss of N-cadherin concentrations at the apical endfeet, which can be partially restored by forced Yap expression and more efficiently by phosphomimetic Yap. These results reveal a novel function of Yap in retaining tissue junctions during normal development and after fetal brain injury. PMID:26754915

Pre-travel health seeking practices of Umrah pilgrims departing from Assiut International Airport, Egypt.

Science.gov (United States)

Aziz, Mirette M; Abd El-Megeed, Hosnia S; Abd Ellatif, Mennat Allah M

2018-04-22

to assess the health seeking practices and their determinants among Umrah pilgrims departing from Assiut international Airport. We interviewed 300 pilgrims departing from Assiut International Airport while they were in the departure lounge, using a semi-structured questionnaire. Only 60%, 46.3% and 46.3% of Umrah pilgrims believed in importance of pre-travel vaccination, seeking health information, and health examination, respectively. The most frequently practiced pre-travel health related behaviour was getting vaccinated (56.3%), as compared to much lower frequencies of seeking health information (24%) or having a clinical health examination (26.7%). Private clinics, internet and the tourism companies were the main sources of health information of the pilgrims. Positive attitude of pilgrims about health seeking practices, the perception of health risk of travelling to Hajj/Umrah and having a chronic disease were the predictors of pre-travel health practices. Raising awareness among Hajj/Umrah pilgrims about the importance of seeking professional pre-travel health advice and communicating the risk of exposure to travel-related diseases to pilgrims could be important strategies to improve the uptake of preventive measures. Training of general practitioners in the public health sector about the travel health information would promote the travel health services. Copyright © 2018. Published by Elsevier Ltd.

Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores.

Science.gov (United States)

Elosegui-Artola, Alberto; Andreu, Ion; Beedle, Amy E M; Lezamiz, Ainhoa; Uroz, Marina; Kosmalska, Anita J; Oria, Roger; Kechagia, Jenny Z; Rico-Lastres, Palma; Le Roux, Anabel-Lise; Shanahan, Catherine M; Trepat, Xavier; Navajas, Daniel; Garcia-Manyes, Sergi; Roca-Cusachs, Pere

2017-11-30

YAP is a mechanosensitive transcriptional activator with a critical role in cancer, regeneration, and organ size control. Here, we show that force applied to the nucleus directly drives YAP nuclear translocation by decreasing the mechanical restriction of nuclear pores to molecular transport. Exposure to a stiff environment leads cells to establish a mechanical connection between the nucleus and the cytoskeleton, allowing forces exerted through focal adhesions to reach the nucleus. Force transmission then leads to nuclear flattening, which stretches nuclear pores, reduces their mechanical resistance to molecular transport, and increases YAP nuclear import. The restriction to transport is further regulated by the mechanical stability of the transported protein, which determines both active nuclear transport of YAP and passive transport of small proteins. Our results unveil a mechanosensing mechanism mediated directly by nuclear pores, demonstrated for YAP but with potential general applicability in transcriptional regulation. Copyright © 2017 Elsevier Inc. All rights reserved.

Probabilistic Nowcasting of Low-Visibility Procedure States at Vienna International Airport During Cold Season

Science.gov (United States)

Kneringer, Philipp; Dietz, Sebastian J.; Mayr, Georg J.; Zeileis, Achim

2018-04-01

Airport operations are sensitive to visibility conditions. Low-visibility events may lead to capacity reduction, delays and economic losses. Different levels of low-visibility procedures (lvp) are enacted to ensure aviation safety. A nowcast of the probabilities for each of the lvp categories helps decision makers to optimally schedule their operations. An ordered logistic regression (OLR) model is used to forecast these probabilities directly. It is applied to cold season forecasts at Vienna International Airport for lead times of 30-min out to 2 h. Model inputs are standard meteorological measurements. The skill of the forecasts is accessed by the ranked probability score. OLR outperforms persistence, which is a strong contender at the shortest lead times. The ranked probability score of the OLR is even better than the one of nowcasts from human forecasters. The OLR-based nowcasting system is computationally fast and can be updated instantaneously when new data become available.

A Novel Notch-YAP Circuit Drives Stemness and Tumorigenesis in Embryonal Rhabdomyosarcoma.

Science.gov (United States)

Slemmons, Katherine K; Crose, Lisa E S; Riedel, Stefan; Sushnitha, Manuela; Belyea, Brian; Linardic, Corinne M

2017-12-01

Rhabdomyosarcoma (RMS), a cancer characterized by skeletal muscle features, is the most common soft-tissue sarcoma of childhood. While low- and intermediate-risk groups have seen improved outcomes, high-risk patients still face a 5-year survival rate of statistic that has not changed in over 40 years. Understanding the biologic underpinnings of RMS is critical. The developmental pathways of Notch and YAP have been identified as potent but independent oncogenic signals that support the embryonal variant of RMS (eRMS). Here, the cross-talk between these pathways and the impact on eRMS tumorigenesis is reported. Using human eRMS cells grown as three-dimensional (3D) rhabdospheres, which enriches in stem cells, it was found that Notch signaling transcriptionally upregulates YAP1 gene expression and YAP activity. Reciprocally, YAP transcriptionally upregulates the Notch ligand genes JAG1 and DLL1 and the core Notch transcription factor RBPJ This bidirectional circuit boosts expression of key stem cell genes, including SOX2 , which is functionally required for eRMS spheres. Silencing this circuit for therapeutic purposes may be challenging, because the inhibition of one node (e.g., pharmacologic Notch blockade) can be rescued by upregulation of another (constitutive YAP expression). Instead, dual inhibition of Notch and YAP is necessary. Finally, supporting the existence of this circuit beyond a model system, nuclear Notch and YAP protein expression are correlated in human eRMS tumors, and YAP suppression in vivo decreases Notch signaling and SOX2 expression. Implications: This study identifies a novel oncogenic signaling circuit driving eRMS stemness and tumorigenesis, and provides evidence and rationale for combination therapies co-targeting Notch and YAP. Mol Cancer Res; 15(12); 1777-91. ©2017 AACR . ©2017 American Association for Cancer Research.

Airports, Hotel, and Ground Transportation Information | Division of Cancer Prevention

Science.gov (United States)

Airports in and near Washington, DC Reagan National (DCA)  Approximate 30 minute drive from Rockville* Has its own Metro stop on the blue and yellow lines in Virginia NOTE: This airport may be the closest and easiest option if not renting a car or do not want to pay for an airport cab/shuttle.   Dulles International (IAD) |

Guidelines to improve airport preparedness against chemical and biological terrorism.

Energy Technology Data Exchange (ETDEWEB)

Edwards, Donna M.; Price, Phillip N. (Lawrence Berkeley National Laboratory, Berkeley, CA); Gordon, Susanna P.; Gadgil, Ashok (Lawrence Berkeley National Laboratory, Berkeley, CA)

2005-05-01

Guidelines to Improve Airport Preparedness Against Chemical and Biological Terrorism is a 100-page document that makes concrete recommendations on improving security and assessing vulnerable areas and helps its readers understand the nature of chemical and biological attacks. The report has been turned over to Airports Council International (ACI) and the American Association of Airport Executives (AAAE), two organizations that together represent the interests of thousands of airport personnel and facilities in the U.S. and around the world.

Nuclear localization of the transcriptional coactivator YAP is associated with invasive lobular breast cancer.

Science.gov (United States)

Vlug, Eva J; van de Ven, Robert A H; Vermeulen, Jeroen F; Bult, Peter; van Diest, Paul J; Derksen, Patrick W B

2013-10-01

Yes Associated Protein (YAP) has been implicated in the control of organ size by regulating cell proliferation and survival. YAP is a transcriptional coactivator that controls cellular responses through interaction with TEAD transcription factors in the nucleus, while its transcriptional functions are inhibited by phosphorylation-dependent translocation to the cytosol. YAP overexpression has been associated with different types of cancer, such as lung, skin, prostate, ovary and liver cancer. Recently, YAP was linked to E-cadherin-dependent regulation of contact inhibition in breast cancer cells. In this study we examined YAP protein expression and cellular localization in 237 cases of human invasive breast cancer by immunohistochemistry and related its expression to clinicopathological features and E-cadherin expression. We observed that invasive lobular carcinoma is characterized by higher expression levels of both nuclear and cytosolic YAP (p invasive breast cancer. We observed that high nuclear and cytosolic YAP expression are associated with the E-cadherin deficient breast cancer subtype ILC (p cancers and conditional mouse models of human lobular breast cancer. Since our data indicate that nuclear YAP localization is more common in breast cancers lacking functional adherens junctions, it suggests that YAP-mediated transcription may be involved in the development and progression of invasive lobular breast cancer.

A Study on Relative Importance and Priority Regarding Airport Selection Attributes Utilizing AHP

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Sung-Oun Oh

2014-10-01

Full Text Available The aim of this study is to investigate relative importance and priority regarding airport selection attributes using Incheon International Airport and Gimpo International Airport, the two main gateway airports to Seoul, Korea, as the target. For the purpose, a survey was carried out with aviation experts as target utilizing five factors which consist of 15 airport selection attributes. The analysis has been conducted on the relative importance and priority of the airport selection factors by expert group using Analytic Hierarchy Process (AHP. As a result of the analysis, the relative importance of airport selection attributes turned out to be different depending on the expert group. Aviation experts working in government agencies and aviation experts working in educational institutions and research institutes regarded accessibility as the most important airport selection factor, and aviation experts working for airlines and companies related to air travel regarded operation as the most important selection factor.

Airport Catchment Area- Example Warsaw Modlin Airport

Science.gov (United States)

Błachut, Jakub

2017-10-01

The form and functions of airports change over time, just like the form and function of cities. Historically, airports are understood as places of aircraft landing, control towers operation and location of other facilities used for communication and transport. This traditional model is giving way to the concept of so-called Airport Cities, based on the assumption that, in addition to its infrastructure and air services, also non-air services are performed, constituting a source of income. At the same time, their reach and impact on the economy of the areas around the airport are expanding. Idea City Airport appeared in the United States in the late twentieth century. The author is J. D. Kasarda, he believes that it is around these big air ports that airport cities develop. In the world, there are currently 45 areas which can be classified in this category, out of which 12 are located in Europe. Main air traffic hubs in Europe are not only the most important passenger traffic junctions, but also largest centres dispatching goods (cargo). It can be said that, among the 30 largest airports, 24 are the largest in terms of both passenger and freight traffic. These airports cover up to 89.9% of the total freight transport of all European airports. At the same time, they serve 56.9% of all passengers in Europe. Based on the concept of Airport City was developed document THE INTEGRATED REGIONAL POLYCENTRIC DEVELOPMENT PLANS FOR THE WARSAW MODLIN AIRPORT CATCHMENT AREA. The plan developed takes into account the findings of the Mazovian voivodeship spatial development plan, specifying the details of its provisions where possible. The development is the first step for the implementation of the concept of the Modlin Airport City. The accomplishment of this ambitious vision will only be possible with hard work of a number of entities, as well as taking into account the former Modlin Fortress, currently under revitalisation, in concepts and plans.

A hairpin within YAP mRNA 3′UTR functions in regulation at post-transcription level

Energy Technology Data Exchange (ETDEWEB)

Gao, Yuen; Wang, Yuan; Feng, Jinyan; Feng, Guoxing; Zheng, Minying; Yang, Zhe; Xiao, Zelin; Lu, Zhanping [State Key Laboratory of Medicinal Chemical Biology, Department of Cancer Research, College of Life Sciences, Nankai University, Tianjin 300071 (China); Ye, Lihong [State Key Laboratory of Medicinal Chemical Biology, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071 (China); Zhang, Xiaodong, E-mail: zhangxd@nankai.edu.cn [State Key Laboratory of Medicinal Chemical Biology, Department of Cancer Research, College of Life Sciences, Nankai University, Tianjin 300071 (China)

2015-04-03

The central dogma of gene expression is that DNA is transcribed into messenger RNAs, which in turn serve as the template for protein synthesis. Recently, it has been reported that mRNAs display regulatory roles that rely on their ability to compete for microRNA binding, independent of their protein-coding function. However, the regulatory mechanism of mRNAs remains poorly understood. Here, we report that a hairpin within YAP mRNA 3′untranslated region (3′UTR) functions in regulation at post-transcription level through generating endogenous siRNAs (esiRNAs). Bioinformatics analysis for secondary structure showed that YAP mRNA displayed a hairpin structure (termed standard hairpin, S-hairpin) within its 3′UTR. Surprisingly, we observed that the overexpression of S-hairpin derived from YAP 3′UTR (YAP-sh) increased the luciferase reporter activities of transcriptional factor NF-κB and AP-1 in 293T cells. Moreover, we identified that a fragment from YAP-sh, an esiRNA, was able to target mRNA 3′UTR of NF2 (a member of Hippo-signaling pathway) and YAP mRNA 3′UTR itself in hepatoma cells. Thus, we conclude that the YAP-sh within YAP mRNA 3′UTR may serve as a novel regulatory element, which functions in regulation at post-transcription level. Our finding provides new insights into the mechanism of mRNAs in regulatory function. - Highlights: • An S-hairpin within YAP mRNA 3′UTR possesses regulatory function. • YAP-sh acts as a regulatory element for YAP at post-transcription level. • YAP-sh-3p20, an esiRNA derived from YAP-sh, targets mRNAs of YAP and NF2. • YAP-sh-3p20 depresses the proliferation of HepG2 cells in vitro.

A hairpin within YAP mRNA 3′UTR functions in regulation at post-transcription level

International Nuclear Information System (INIS)

Gao, Yuen; Wang, Yuan; Feng, Jinyan; Feng, Guoxing; Zheng, Minying; Yang, Zhe; Xiao, Zelin; Lu, Zhanping; Ye, Lihong; Zhang, Xiaodong

2015-01-01

The central dogma of gene expression is that DNA is transcribed into messenger RNAs, which in turn serve as the template for protein synthesis. Recently, it has been reported that mRNAs display regulatory roles that rely on their ability to compete for microRNA binding, independent of their protein-coding function. However, the regulatory mechanism of mRNAs remains poorly understood. Here, we report that a hairpin within YAP mRNA 3′untranslated region (3′UTR) functions in regulation at post-transcription level through generating endogenous siRNAs (esiRNAs). Bioinformatics analysis for secondary structure showed that YAP mRNA displayed a hairpin structure (termed standard hairpin, S-hairpin) within its 3′UTR. Surprisingly, we observed that the overexpression of S-hairpin derived from YAP 3′UTR (YAP-sh) increased the luciferase reporter activities of transcriptional factor NF-κB and AP-1 in 293T cells. Moreover, we identified that a fragment from YAP-sh, an esiRNA, was able to target mRNA 3′UTR of NF2 (a member of Hippo-signaling pathway) and YAP mRNA 3′UTR itself in hepatoma cells. Thus, we conclude that the YAP-sh within YAP mRNA 3′UTR may serve as a novel regulatory element, which functions in regulation at post-transcription level. Our finding provides new insights into the mechanism of mRNAs in regulatory function. - Highlights: • An S-hairpin within YAP mRNA 3′UTR possesses regulatory function. • YAP-sh acts as a regulatory element for YAP at post-transcription level. • YAP-sh-3p20, an esiRNA derived from YAP-sh, targets mRNAs of YAP and NF2. • YAP-sh-3p20 depresses the proliferation of HepG2 cells in vitro

77 FR 64838 - Notice of Intent To Rule on Request To Release Airport Property at the Seattle-Tacoma...

Science.gov (United States)

2012-10-23

... To Release Airport Property at the Seattle-Tacoma International Airport, Seattle, Washington AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of request to release airport property. SUMMARY... International Airport under the provisions of Section 125 of the Wendell H. Ford Aviation Investment Reform Act...

78 FR 15112 - Notice of Intent To Rule on Request To Release Airport Property at the Seattle-Tacoma...

Science.gov (United States)

2013-03-08

... To Release Airport Property at the Seattle-Tacoma International Airport, Seattle, Washington AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Request to Release Airport Property. SUMMARY... International Airport under the provisions of Section 125 of the Wendell H. Ford Aviation Investment Reform Act...

Energy Stress Regulates Hippo-YAP Signaling Involving AMPK-Mediated Regulation of Angiomotin-like 1 Protein

Directory of Open Access Journals (Sweden)

Michael DeRan

2014-10-01

Full Text Available Hippo signaling is a tumor-suppressor pathway involved in organ size control and tumorigenesis through the inhibition of YAP and TAZ. Here, we show that energy stress induces YAP cytoplasmic retention and S127 phosphorylation and inhibits YAP transcriptional activity and YAP-dependent transformation. These effects require the central metabolic sensor AMP-activated protein kinase (AMPK and the upstream Hippo pathway components Lats1/Lats2 and angiomotin-like 1 (AMOTL1. Furthermore, we show that AMPK directly phosphorylates S793 of AMOTL1. AMPK activation stabilizes and increases AMOTL1 steady-state protein levels, contributing to YAP inhibition. The phosphorylation-deficient S793Ala mutant of AMOTL1 showed a shorter half-life and conferred resistance to energy-stress-induced YAP inhibition. Our findings link energy sensing to the Hippo-YAP pathway and suggest that YAP may integrate spatial (contact inhibition, mechanical, and metabolic signals to control cellular proliferation and survival.

YAP/TAZ enhance mammalian embryonic neural stem cell characteristics in a Tead-dependent manner

Energy Technology Data Exchange (ETDEWEB)

Han, Dasol; Byun, Sung-Hyun; Park, Soojeong; Kim, Juwan; Kim, Inhee; Ha, Soobong; Kwon, Mookwang; Yoon, Keejung, E-mail: keejung@skku.edu

2015-02-27

Mammalian brain development is regulated by multiple signaling pathways controlling cell proliferation, migration and differentiation. Here we show that YAP/TAZ enhance embryonic neural stem cell characteristics in a cell autonomous fashion using diverse experimental approaches. Introduction of retroviral vectors expressing YAP or TAZ into the mouse embryonic brain induced cell localization in the ventricular zone (VZ), which is the embryonic neural stem cell niche. This change in cell distribution in the cortical layer is due to the increased stemness of infected cells; YAP-expressing cells were colabeled with Sox2, a neural stem cell marker, and YAP/TAZ increased the frequency and size of neurospheres, indicating enhanced self-renewal- and proliferative ability of neural stem cells. These effects appear to be TEA domain family transcription factor (Tead)–dependent; a Tead binding-defective YAP mutant lost the ability to promote neural stem cell characteristics. Consistently, in utero gene transfer of a constitutively active form of Tead2 (Tead2-VP16) recapitulated all the features of YAP/TAZ overexpression, and dominant negative Tead2-EnR resulted in marked cell exit from the VZ toward outer cortical layers. Taken together, these results indicate that the Tead-dependent YAP/TAZ signaling pathway plays important roles in neural stem cell maintenance by enhancing stemness of neural stem cells during mammalian brain development. - Highlights: • Roles of YAP and Tead in vivo during mammalian brain development are clarified. • Expression of YAP promotes embryonic neural stem cell characteristics in vivo in a cell autonomous fashion. • Enhancement of neural stem cell characteristics by YAP depends on Tead. • Transcriptionally active form of Tead alone can recapitulate the effects of YAP. • Transcriptionally repressive form of Tead severely reduces stem cell characteristics.

YAP/TAZ enhance mammalian embryonic neural stem cell characteristics in a Tead-dependent manner

International Nuclear Information System (INIS)

Han, Dasol; Byun, Sung-Hyun; Park, Soojeong; Kim, Juwan; Kim, Inhee; Ha, Soobong; Kwon, Mookwang; Yoon, Keejung

2015-01-01

Mammalian brain development is regulated by multiple signaling pathways controlling cell proliferation, migration and differentiation. Here we show that YAP/TAZ enhance embryonic neural stem cell characteristics in a cell autonomous fashion using diverse experimental approaches. Introduction of retroviral vectors expressing YAP or TAZ into the mouse embryonic brain induced cell localization in the ventricular zone (VZ), which is the embryonic neural stem cell niche. This change in cell distribution in the cortical layer is due to the increased stemness of infected cells; YAP-expressing cells were colabeled with Sox2, a neural stem cell marker, and YAP/TAZ increased the frequency and size of neurospheres, indicating enhanced self-renewal- and proliferative ability of neural stem cells. These effects appear to be TEA domain family transcription factor (Tead)–dependent; a Tead binding-defective YAP mutant lost the ability to promote neural stem cell characteristics. Consistently, in utero gene transfer of a constitutively active form of Tead2 (Tead2-VP16) recapitulated all the features of YAP/TAZ overexpression, and dominant negative Tead2-EnR resulted in marked cell exit from the VZ toward outer cortical layers. Taken together, these results indicate that the Tead-dependent YAP/TAZ signaling pathway plays important roles in neural stem cell maintenance by enhancing stemness of neural stem cells during mammalian brain development. - Highlights: • Roles of YAP and Tead in vivo during mammalian brain development are clarified. • Expression of YAP promotes embryonic neural stem cell characteristics in vivo in a cell autonomous fashion. • Enhancement of neural stem cell characteristics by YAP depends on Tead. • Transcriptionally active form of Tead alone can recapitulate the effects of YAP. • Transcriptionally repressive form of Tead severely reduces stem cell characteristics

Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans

Energy Technology Data Exchange (ETDEWEB)

Iwasa, Hiroaki [Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113-8519 (Japan); Maimaiti, Sainawaer [Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113-8519 (Japan); Department of Psychotherapy, The Fourth People' s Hospital of Urumqi, Urumqi 830000 (China); Kuroyanagi, Hidehito [Laboratory of Gene Expression, Graduate School of Biomedical Science, Tokyo Medical and Dental University, Tokyo 113-8519 (Japan); Kawano, Shodai; Inami, Kazutoshi; Timalsina, Shikshya; Ikeda, Mitsunobu; Nakagawa, Kentaro [Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113-8519 (Japan); Hata, Yutaka, E-mail: yuhammch@tmd.ac.jp [Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113-8519 (Japan)

2013-04-15

The mammalian Hippo pathway comprises mammalian Ste20-like kinases (MST1/2) and large tumor suppressor kinases (LATS1/2). LATS1/2, which are activated by MST1/2, phosphorylate a transcriptional co-activator, yes-associated protein (YAP), and induce the recruitment of YAP by 14-3-3 to cytoplasm, so that the TEAD-dependent gene transcriptions are turned off. Although the core components of the Hippo pathway are well conserved in metazoans, it has been discussed that Caenorhabditis elegans lacks YAP ortholog, we found that F13E6.4 gene encodes a protein that shows sequence similarities to YAP in the N-terminal TEAD-binding domain and in the WW domain. We designated this gene as yap-1. YAP-1 is widely expressed in various cells such as epithelial cells, muscles, hypodermal cells, gonadal sheath cells, spermatheca, and hypodermal cells. YAP-1 is distributed in cytoplasm and nuclei. wts-1 (LATS ortholog) and ftt-2 (14-3-3 ortholog) knockdowns cause nuclear accumulation of YAP-1, supporting that the subcellular localization of YAP-1 is regulated in a similar way as that of YAP. Heat shock also causes the nuclear accumulation of YAP-1 but after heat shock, YAP-1 translocates to cytoplasm. Knockdowns of DAF-21 (HSP90 ortholog) and HSF-1block the nuclear export of YAP-1 during this recovery. YAP-1 overexpression is beneficial for thermotolerance, whereas YAP-1 hyperactivity induced by wts-1 and ftt-2 knockdowns is deleterious on thermal response and yap-1 deficiency promotes health aging. In short, YAP-1 partially shares basal characters with mammalian YAP and plays a role in thermal stress response and healthy aging. - Highlights: ► We named Caenorhabditis elegans F13E6.4 gene yap-1 as a putative YAP homolog. ► The localization of YAP-1 is regulated by WTS-1 and FTT-2. ► YAP-1 is involved in healthy aging and thermosensitivity.

Optimization of LSO/LuYAP phoswich detector for small animal PET

International Nuclear Information System (INIS)

Jung, Jin Ho; Choi, Yong; Chung, Yong Hyun; Devroede, Olivier; Krieguer, Magalie; Bruyndonckx, Peter; Tavernier, Stefaan

2007-01-01

LSO/LuYAP phoswich detectors for small animal PET were developed to measure the depth of interaction (DOI), and to improve the spatial resolution at the edge of the field of view (FOV). The aim of this study was to optimize the optical coupling conditions between the crystal and photomultiplier tube (PMT) to maximize the light-collection efficiency, and to develop a method for rejecting scatter events by applying an equal energy window in each crystal layer. The light yields of the phoswich detector were estimated by changing the refractive index of the optical coupling material using a DETECT simulation. The accuracy of the DOI measurement on the phoswich detector, using an optical coupling material with the optimal light yield, were evaluated experimentally and compared with the air condition. The energy window for the photopeak events cannot be applied properly because the light outputs of LSO and LuYAP are different. The LSO/LuYAP photopeaks need to be superposed in order to effectively discriminate the scattered events by applying an equal energy window. The photopeaks of the LSO and LuYAP can be superposed by inserting a reflecting material between the crystals. The optimal coverage ratio of the inserting material was derived from a DETECT simulation, and its performance was investigated. In the simulation result, optimal refractive index of the optical coupling material was 1.7. The average DOI measurement errors of the LSO/LuYAP were 0.6%/3.4% and 4.9%/41.4% in the phoswich detector with and without an optical coupling material, respectively. The photopeaks of the LSO and LuYAP were superposed by covering 75% of the contact surface between the crystals with white Teflon. The DOI measurement errors of the LSO/LuYAP were 0.2%/2.4%. In this study, the optimal condition of the optical coupling material inserted between the crystal and PMT was derived to improve the accuracy of DOI measurement, and a photopeak superposition method of the LSO and LuYAP was

Noise-Induced Sleep Disturbance in Residences Near Two Civil Airports

Science.gov (United States)

Fidell, Sanford; Howe, Richard R.; Tabachnick, Barbara G.; Pearsons, Karl S.; Sneddon, Matthew D.

1995-01-01

A large-scale field study of noise-induced sleep disturbance was conducted in the vicinities of Stapleton International Airport (DEN) and Denver International Airport (DIA) in anticipation of the closure of the former and opening of the latter. Both indoor and outdoor measurements of aircraft and other nighttime noises were made during four time periods. Measurements were made in 57 homes located as close as feasible to the runway ends of the two airports. Sleep disturbance was measured by several indices of behaviorally confirmed awakening (button pushes upon awakening) and body movement (as measured with wrist-worn actimeters). A total of 2717 subject-nights of observations were made over the course of the study. Although average noise event levels measured outdoors decreased markedly at DEN after closure of the airport and increased slightly at DIA after its opening, indoor noise event levels varied much less in homes near both airports. No large differences were observed in noise-induced sleep disturbance at either airport. Indoor sound exposure levels of noise events were, however, closely related to and good predictors of actimetrically defined motility and arousal.

Hydrogen applications for Lambert-St. Louis International Airport

Science.gov (United States)

2009-01-01

Today, major airports are facing challenges related to pollution, energy efficiency, and safety and security. Hydrogen and fuel cell technologies, regarded as one of the key energy solutions of the 21st century are more energy efficient and reliable ...

Conceptual Approach to Formation of Competitiveness of the Leading International Airports under Conditions of the World Trajectory of the Airline Market Development

Directory of Open Access Journals (Sweden)

Sydorenko Kateryna V.

2014-03-01

Full Text Available Potential of competitiveness of the airport, as any other enterprise of the service sphere, is determined by the corporate power of the producer of these values. The issue of development of the infrastructure development strategy of leading international airports, which sets the goal of solution of the problem of complete, timely, uninterrupted and high quality satisfaction of the fast growing demand of services consumers with minimal costs, becomes extremely urgent under conditions of dynamic development of the world aviation. However, the airport infrastructure is rather wasteful and requires permanent investments into renovation of the infrastructure objects and technological systems. The airport infrastructure is a set of objects, which are divided, by their functional purpose, into objects that directly service the technological process of air conveyance (sphere of aviation activity and objects that create additional services. Increase of competitiveness of the airport in the world economic environment envisages timely modernisation and harmonious development of its objects in accordance with requirements of the airport services market on the basis of rational resource provision and efficient management of the property complex at all stages of functioning and development. The author studies aspects of formation of the competitive strategy of the airport, identifies strategic priorities of development of the airport infrastructure, including through the mechanism of state-private partnership, use of transit potential, strengthening of the logistical component, increase of quality of servicing, and diversification of activity by means of strengthening its non-aviation component with consideration of goals of efficient integration in the national and global environment.

Airport Capital Improvement Planning: Stewardship for Airport Development

Science.gov (United States)

1997-09-01

"Airport Capital Improvement Planning: Stewardship for Airport Development", was : originally written in October, 1995. It documented an effort to implement the : concept of capital improvement planning with the airport development industry. : Airpor...

Efficient 2-μm Tm:YAP Q-switched and CW lasers

Science.gov (United States)

Hays, A. D.; Cole, Brian; King, Vernon; Goldberg, Lew

2018-02-01

Highly efficient, diode pumped Tm:YAP lasers generating emission in the 1.85-1.94 μm range are demonstrated and characterized. Laser optical efficiencies of 51% and 45%, and electrical efficiencies of 31% and 25% are achieved under CW and Q-switched operation, respectively. Laser performance was characterized for maximum average powers up to 20W with various cavity configurations, all using an intra-cavity lens to compensate for thermal lensing in the Tm:YAP crystal. Q-switched lasers incorportating a Cr:ZnS saturable absorber (SA), resonant mechanical mirror scanner, or acousto-optic modulator were characterized. To enable higher average output powers, measurements of the thermal lens were conducted for the Tm:YAP crystal as a function of pump power and were compared to values predicted by a finiteelement- analysis (FEA) thermal-optical model of the Tm:YAP crystal. A resonator model is developed to incorporate this calculated thermal lens and its effect on laser performance. This paper will address approaches for improving the performance of Tm:YAP lasers, and means for achieving increased average output powers while maintaining high optical efficiency for both SA and mechanical Q-switching.

STRATEGIC MARKET POSITION OF THE GDANSK AIRPORT

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Henryk Ćwikliński

2015-09-01

Full Text Available Airports are a key link of the air transport infrastructure, which is a part of the whole transportation system. Their potential is determined by a network of airlines relations and affects the long-term, strategic position in the market of aviation services. The most possible scenario of the macro-environment of the Gdansk Airport has a relatively high predictability and generally positive influencing on the potential for development in the next years. Only international and demographic areas can constitute a barrier to achieving the strategic objectives. Gdansk Airport takes permanently the third position on the Polish market. Strategic gap analysis leads to the conclusion that, compared to its main competitors Airport Gdansk has a gap of compliance trends, but in relation to smaller regional airports excess gap. GDN services are located in the square "Star" in the BCG matrix. This airport has prepared an investment program till 2035. The dynamics of the projected increase in the number of passengers and air operations in Gdansk is generally slightly higher than the growth nationwide forecasts. The strategic challenge for next years will be to strengthen the status of the GDN as a Polish aviation gateway to Scandinavia.

Multi-year consumption analysis and innovative energy perspectives: The case study of Leonardo da Vinci International Airport of Rome

International Nuclear Information System (INIS)

Rubeis, Tullio de; Nardi, Iole; Paoletti, Domenica; Di Leonardo, Antonella; Ambrosini, Dario; Poli, Ruggero; Sfarra, Stefano

2016-01-01

Highlights: • A systematic approach for energy management of complex structures is proposed. • Technological systems of Leonardo da Vinci Airport of Rome are described. • A multi-year consumption analysis highlights the most energy-consuming sectors. • The “Smart Grid” prototype project inherent to T1 Terminal is presented. • Wind and photovoltaic plants are designed and discussed to test the smart storage. - Abstract: Because of the growing need for efficient energy production systems, energy policies promoted in recent years have also involved complex structures, like airports. This paper proposes the implementation of an energy management system for a very energy-consuming structure, composed of different power plants and many energy consumers: the Leonardo da Vinci International Airport of Rome. In this study, the examination of historical data related to airport electric power, thermal energy and fuel consumption is discussed, starting with the analysis of the production energy plants, mainly based on a combined heat and power system. Furthermore, pioneering solutions are proposed, not only to cover airport energy requirements, but also to test the safety and reliability of innovative load management systems. For this reason, the choice of the Leonardo da Vinci management company, oriented to install a smart storage in order to manage the bidirectional energy flows by consumers and producers, is justified. Such innovative energy procurement systems are examined, with the goal of achieving greater penetration of renewable sources: mini and micro wind power plants and high concentrator photovoltaic plants.

Airport Heterotopia

OpenAIRE

Christiansen, Steen Ledet

2008-01-01

Airports are areas of transit, places of in-between-ness where mobility is key; airports function not just as transfer points where people are moved from one place to another, but also as areas where mobile technology is critically important to make sure that travellers can stay connected. The airport serves as a node in the network of flows that is air travel. Airports orchestrate social life into distinct movements and behaviors.The ontology of the airport is peculiarly split between a sens...

Light emission efficiency and imaging properties of YAP:Ce granular phosphor screens

International Nuclear Information System (INIS)

Kalivas, N.; Valais, I.; Nikolopoulos, D.; Konstantinidis, A.; Cavouras, D.; Kandarakis, I.; Gaitanis, A.; Nomicos, C.D.; Panayiotakis, G.

2007-01-01

Phosphor materials are used in medical imaging combined with radiographic film or other photodetectors. Cerium (Ce 3+ ) -doped scintillators are of particular interest for medical imaging, because of their very fast response. YAP:Ce scintillator-based image detectors have already been evaluated in single-crystal form and under conditions of positron emission tomography and synchrotron or γ-ray irradiation. Furthermore, YAP:Ce phosphor has been evaluated in conjunction with radiographic films. The present work reports experimental and theoretical data concerning the light output absolute luminescence efficiency (AE) of the YAP:Ce screens under irradiation conditions employed in medical X-ray projection imaging (i.e., in diagnostic radiology). projection imaging (i.e., in diagnostic radiology). YAP:Ce phosphor screens with surface densities ranging between 53 and 110 mg/cm 2 were prepared by sedimentation on fused silica substrates in our laboratory. The resulted surface density of the screens was determined by dividing the phosphor mass deposited on the screen surface with the area of the surface. Additionally this work addresses the imaging performance of YAP:Ce by estimation of the detective quantum efficiency (DQE), i.e., the square of the signal to noise ratio transfer. Absolute efficiency was found to decrease with X-ray tube voltage for for YAP:Ce phosphor. The highest experimental efficiency was obtained for the 53.7 mg/cm 2 and 88.0 mg/cm 2 YAP:Ce screens. The highest DQE value was found for the 88.0 mg/cm 2 screen irradiated at 60 kVp. (orig.)

CERN lands a slot at Geneva Airport

CERN Multimedia

2002-01-01

From left to right:Carlo Lamprecht, Luciano Maiani and Jean-Pierre Jobin. When you step off your plane at Geneva Airport there's a good chance you'll come face-to-face with an advertising hoarding bearing the message 'CERN, the world's largest particle physics research laboratory, where the World Wide Web was born...five minutes from here'. This may be obvious to you, but it certainly isn't to the majority of the 7 million travellers who pass through the gates of Geneva Airport every year. On the initiative of the Chairman of its Board of Directors, State Councillor Carlo Lamprecht, Geneva International Airport has therefore come up with the idea of highlighting CERN's presence by giving the Laboratory its own hoarding. The hoarding was inaugurated on 24 May by Carlo Lamprecht, Airport Director Jean-Pierre Jobin and CERN Director-General Luciano Maiani.

Does Occupational Exposure of Shahid Dastghieb International Airport Workers to Radiofrequency Radiation Affect Their Short Term Memory and Reaction Time?

Directory of Open Access Journals (Sweden)

Jarideh S.

2015-05-01

Full Text Available Background: Airport workers are continuously exposed to different levels of radiofrequency microwave (RF/MW radiation emitted by radar equipments. Radars are extensively used in military and aviation industries. Over the past several years, our lab has focused on the health effects of exposure to different sources of electromagnetic fields such as cellular phones, mobile base stations, mobile phone jammers, laptop computers, radars, dentistry cavitrons and MRI. The main goal of this study was to investigate if occupational exposure of Shahid Dastghieb international airport workers to radiofrequency radiation affects their short term memory and reaction time. Methods: Thirty two airport workers involved in duties at control and approach tower (21 males and 11 females, with the age range of 27-67 years old (mean age of 37.38, participated voluntary in this study. On the other hand, 29 workers (13 males, and 16 females whose offices were in the city with no exposure history to radar systems were also participated in this study as the control group. The employees’ reaction time and short term memory were analyzed using a standard visual reaction time (VRT test software and the modified Wechsler memory scale test, respectively. Results: The mean± SD values for the reaction times of the airport employees (N=32 and the control group (N=29 were 0.45±0.12 sec and 0.46±0.17 sec, respectively. Moreover, in the four subset tests; i.e. paired words, forward digit span, backward digit span and word recognition, the following points were obtained for the airport employees and the control group, respectively: (i pair words test: 28.00±13.13 and 32.07±11.65, (ii forward digit span: 8.38±1.40 and 9.03±1.32, (iii backward digit span: 5.54±1.87 and 6.31±1.46, and (iv word recognition: 5.73±2.36 and 6.50±1.93. These differences were not statistically significant. Conclusion: The occupational exposure of the employees to the RF radiation in Shahid

AIRPORTS CLASSIFICATION AND PRIORITY OF THEIR RECONSTRUCTION

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K. V. Marintseva

2014-03-01

Full Text Available Purpose. It is important for Ukraine to have a network of airports, which would promote the current and long-term implementation of air transportation needs of the population and the economics. This study aims to establish criteria of airports classification to determine their role in the development of the air transport system of Ukraine. Methodology. The methods of statistical analysis were used for the processing of data according to categories of airport productivity and geographic information system for data visualization. Findings. It is established that the existing division of Ukrainian airports into international and domestic, as well as into coordinated and non-coordinated ones is not relevant for determining the role of airport in the development of air transport system of the country and accordingly for the priority in financing of their modernization. The approach to the determination of airports classifications using analysis of performance categories was developed. Originality. Classification criterions of the airports in Ukraine are proposed: by type of activity and by the maintenance of scheduled route network. It is proposed to classify the airports by the type of activity to the primary commercial, commercial, cargo primary commercial, cargo commercial and general aviation. According to the scheduled route network maintenane it is proposed to classify the airports as the primary, non-primary and auxiliary hubs. An example of classification by the given criteria is submitted. Practical value. The value of the obtained results is in the possibility of using the proposed classification in the task of determining the priorities for financing the country's airports. As opposed to the practice of directed funding procedure in the framework of the state program of airports development, it is proposed to take into account the fact that the resumption of the functioning of the airport and/or its modernization should be as a response to

Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival.

Science.gov (United States)

Lin, Zhiqiang; Zhou, Pingzhu; von Gise, Alexander; Gu, Fei; Ma, Qing; Chen, Jinghai; Guo, Haidong; van Gorp, Pim R R; Wang, Da-Zhi; Pu, William T

2015-01-02

Yes-associated protein (YAP), the nuclear effector of Hippo signaling, regulates cellular growth and survival in multiple organs, including the heart, by interacting with TEA (transcriptional enhancer activator)-domain sequence-specific DNA-binding proteins. Recent studies showed that YAP stimulates cardiomyocyte proliferation and survival. However, the direct transcriptional targets through which YAP exerts its effects are poorly defined. To identify direct YAP targets that mediate its mitogenic and antiapoptotic effects in the heart. We identified direct YAP targets by combining differential gene expression analysis in YAP gain- and loss-of-function with genome-wide identification of YAP-bound loci using chromatin immunoprecipitation and high throughput sequencing. This screen identified Pik3cb, encoding p110β, a catalytic subunit of phosphoinositol-3-kinase, as a candidate YAP effector that promotes cardiomyocyte proliferation and survival. YAP and TEA-domain occupied a conserved enhancer within the first intron of Pik3cb, and this enhancer drove YAP-dependent reporter gene expression. Yap gain- and loss-of-function studies indicated that YAP is necessary and sufficient to activate the phosphoinositol-3-kinase-Akt pathway. Like Yap, Pik3cb gain-of-function stimulated cardiomyocyte proliferation, and Pik3cb knockdown dampened YAP mitogenic activity. Reciprocally, impaired heart function in Yap loss-of-function was significantly rescued by adeno-associated virus-mediated Pik3cb expression. Pik3cb is a crucial direct target of YAP, through which the YAP activates phosphoinositol-3-kinase-AKT pathway and regulates cardiomyocyte proliferation and survival. © 2014 American Heart Association, Inc.

The Need for an Implant Identification Card at Airport Security Check.

Science.gov (United States)

Ali, Erden; Kosuge, Dennis; MacDowell, Andrew

2017-06-01

Joint replacement surgery is having an increasing demand as national healthcare systems confront an ever ageing population. Surgical complications associated with lower limb arthroplasty are well known but less investigation has been performed examining its effect on air travel, more specifically, unwanted and significant inconvenience caused to travelers going through airport security. In lower limb arthroplasty clinics, 50 patients who met our selection criteria were given questionnaires. Ten airport security officers from 4 international airports (London Stansted, London Gatwick, London Heathrow, and Amsterdam Schiphol International Airport) were also given a separate questionnaire. The opinion of the Civil Aviation Authority was also sought. All 50 patients (mean age, 70.4 years; range, 55 to 84 years) who were presenting in lower limb arthroplasty clinics and who met our selection criteria volunteered to enter the study. Twenty-eight of these patients were female (mean age, 69.1 years; range, 55 to 84 years) and 22 were male (mean age, 71.2 years; range, 58 to 81 years). Of the patients, 14% stated that their joint replacements did not set off the airport security alarm. Responses were received from 10 airport security officers as well. Six airport security officers were male and 4 were female. All of the airport officers were aware of some form of implant identification card with 90% stating that these were useful to them at airport security. Eight-four percent of the patients stated that an implant identification card outlining what joint replacement they possessed and when this had been done would be very useful. Sixteen percent of the patients did not think a card would be beneficial since all of them had set off the airport alarm system only once or less in their lifetime. It is the opinion of airport security officers and patients that joint replacement implant identification cards streamline airport security checks and decrease the need for more

Derin Yapı Yüzey Yapı İlişkisi Bağlamında Temel Dil Becerileri Üzerine Bir Analiz Çalışması

Directory of Open Access Journals (Sweden)

Bilginer ONAN

2015-07-01

Full Text Available Bu çalışmada, derin yapı yüzey yapı ilişkileri bağlamında, ana dili eğitiminde temel dil becerileri olarak kabul edilen dinleme, konuşma, okuma ve yazma kavramları analiz edilmiştir. Birinci bölümde, ilk kez Port Royal Gramer Okulu tarafından ortaya konan ve 1960’larda Noam Chomsky tarafından Üretimci Dönüşümsel Dil Bilgisi kuramıyla tekrar gündeme getirilen derin yapı ve yüzey yapı kavramları hakkında bilgi verilmiştir. Çalışmanın ikinci bölümünde ise derin yapı ve yüzey yapı ilişkileri çerçevesinde dinleme, konuşma, okuma ve yazma becerileri analiz edilmiştir. Çalışmanın amacı, dilin iki temel boyutu olan anlam ve biçim ilişkileri bağlamında, temel dil becerilerinin eğitimi sürecinde belirleyici olan unsurları tespit ederek, sürecin programlanmasına yönelik öneriler geliştirmektir. Çalışma çerçevesinde yapılan analizlerde boğumlama, bürün olguları, beden dili, üretici kelime hazinesi, alıcı kelime hazinesi, akıcılık, metin türü, yazım ve noktalama, bağdaşıklık, tutarlılık, ön bilgi, kelime tanıma, kelime ayırt etme, edinilmiş bilgi, önvarsayım, sezdirim kavramlarının derin yapı yüzey yapı ilişkileri bağlamında temel dil becerilerinin geliştirilmesinde süreci etkileyen unsurlar olduğu tespit edilmiştir. Bu kavramlar arasında boğumlama, bürün olgusu, beden dili, akıcılık, bağdaşıklık, metin türü, kelime tanıma, kelime ayırt etme, yazım ve noktalama, doğrudan yüzey yapıyla ilgilidir. Üretici kelime hazinesi, akıcılık, alıcı kelime hazinesi, tutarlılık, ön bilgi, edinilmiş bilgi, önvarsayım ve sezdirim kavramları ise derin yapıyı ilgilendirmektedir. Akıcılık kavramının bütün dil becerileriyle ilgili olduğu belirlenmiştir.

Nf2-Yap signaling controls the expansion of DRG progenitors and glia during DRG development.

Science.gov (United States)

Serinagaoglu, Yelda; Paré, Joshua; Giovannini, Marco; Cao, Xinwei

2015-02-01

Molecular mechanisms governing the maintenance and proliferation of dorsal root ganglia (DRG) progenitors are largely unknown. Here we reveal that the Hippo pathway regulates the expansion of DRG progenitors and glia during mammalian DRG development. The key effectors of this pathway, transcriptional coactivators Yap and Taz, are expressed in DRG progenitors and glia during DRG development but are at least partially inhibited from activating transcription. Aberrant YAP activation leads to overexpansion of DRG progenitor and glial populations. We further show that the Neurofibromatosis 2 (Nf2) tumor suppressor inhibits Yap during DRG development. Loss of Nf2 leads to similar phenotypes as does YAP hyperactivation, and deleting Yap suppresses these phenotypes. Our study demonstrates that Nf2-Yap signaling plays important roles in controlling the expansion of DRG progenitors and glia during DRG development. Copyright © 2014 Elsevier Inc. All rights reserved.

Vanillin causes the activation of Yap1 and mitochondrial fragmentation in Saccharomyces cerevisiae.

Science.gov (United States)

Nguyen, Trinh Thi My; Iwaki, Aya; Ohya, Yoshikazu; Izawa, Shingo

2014-01-01

Vanillin and furfural are derived from lignocellulosic biomass and inhibit yeast growth and fermentation as biomass conversion inhibitors. Furfural has been shown to induce oxidative stress in Saccharomyces cerevisiae. Since there has been no report on the relationship between vanillin and oxidative stress, we investigated whether vanillin caused oxidative stress in yeast cells. We showed that vanillin caused the nuclear accumulation of Yap1, an oxidative stress responsive transcription factor, and subsequent transcriptional activation of Yap1-target genes. The growth of the null mutant of the YAP1 gene (yap1Δ) was delayed in the presence of vanillin, which indicated that Yap1 plays a role in the acquisition of tolerance to vanillin. We also demonstrated that vanillin facilitated the fragmentation of mitochondria. These findings suggest that the toxicity of vanillin involves damage induced by oxidative stress. Copyright © 2013 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

The International Airport of Geneva is a permanent work site; Aeroport international de Geneve. Le chantier permanent

Energy Technology Data Exchange (ETDEWEB)

Jaques, A.

2000-07-01

Different aspects of the construction of a building extension to the Geneva-Cointrin Airport in Switzerland are approached. At the end of the work, the airport will count six new gates. The priorities of the project are the comfort and the security of the passengers, the minimisation of energy consumption and environmental impact. A large part of the building facades is glassy favouring daylighting and natural space heating. In summer, a network of water-cooled tubes and plates hanging close to the ceiling makes up the air cooling. Globally, the airport fuel consumption has decreased since 1987, while the built surface has more than doubled. The installation, in 1996, of four Low-Nox burners in the thermal power plant also contributed to save primary energy.

Hippo/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung

Science.gov (United States)

Lange, Alexander W.; Sridharan, Anusha; Xu, Yan; Stripp, Barry R.; Perl, Anne-Karina; Whitsett, Jeffrey A.

2015-01-01

The Hippo/Yap pathway is a well-conserved signaling cascade that regulates cell proliferation and differentiation to control organ size and stem/progenitor cell behavior. Following airway injury, Yap was dynamically regulated in regenerating airway epithelial cells. To determine the role of Hippo signaling in the lung, the mammalian Hippo kinases, Mst1 and Mst2, were deleted in epithelial cells of the embryonic and mature mouse lung. Mst1/2 deletion in the fetal lung enhanced proliferation and inhibited sacculation and epithelial cell differentiation. The transcriptional inhibition of cell proliferation and activation of differentiation during normal perinatal lung maturation were inversely regulated following embryonic Mst1/2 deletion. Ablation of Mst1/2 from bronchiolar epithelial cells in the adult lung caused airway hyperplasia and altered differentiation. Inhibitory Yap phosphorylation was decreased and Yap nuclear localization and transcriptional targets were increased after Mst1/2 deletion, consistent with canonical Hippo/Yap signaling. YAP potentiated cell proliferation and inhibited differentiation of human bronchial epithelial cells in vitro. Loss of Mst1/2 and expression of YAP regulated transcriptional targets controlling cell proliferation and differentiation, including Ajuba LIM protein. Ajuba was required for the effects of YAP on cell proliferation in vitro. Hippo/Yap signaling regulates Ajuba and controls proliferation and differentiation of lung epithelial progenitor cells. PMID:25480985

Airport Heterotopia

DEFF Research Database (Denmark)

Christiansen, Steen Ledet

Airports are areas of transit, places of in-between-ness where mobility is key; airports function not just as transfer points where people are moved from one place to another, but also as areas where mobile technology is critically important to make sure that travellers can stay connected....... The airport serves as a node in the network of flows that is air travel. Airports orchestrate social life into distinct movements and behaviors. The ontology of the airport is peculiarly split between a sense of placelessness, while at the same time being a place of material organization and social complexity....... It is a system of interconnected material worlds, and thus a heterotopia; a blending space of overlapping ontologies. Ursula Le Guin playfully examines this concept of overlapping ontologies in her short story collection Changing Planes, where airport travellers can shift realities due to the unpleasantries...

75 FR 16900 - Notice of Intent To Rule on Request To Release Airport Property at the Cincinnati/Northern...

Science.gov (United States)

2010-04-02

... To Release Airport Property at the Cincinnati/Northern Kentucky International Airport, Hebron, KY.../Northern Kentucky International Airport in the city of Hebron, Kentucky. This property, approximately 75.88... Investment Reform Act for the 21st Century (AIR 21). DATES: Comments must be received on or before May 3...

Productivity Analysis of Public and Private Airports: A Causal Investigation

Science.gov (United States)

Vasigh, Bijan; Gorjidooz, Javad

2007-01-01

Around the world, airports are being viewed as enterprises, rather than public services, which are expected to be managed efficiently and provide passengers with courteous customer services. Governments are, increasingly, turning to the private sectors for their efficiency in managing the operation, financing, and development, as well as providing security for airports. Operational and financial performance evaluation has become increasingly important to airport operators due to recent trends in airport privatization. Assessing performance allows the airport operators to plan for human resources and capital investment as efficiently as possible. Productivity measurements may be used as comparisons and guidelines in strategic planning, in the internal analysis of operational efficiency and effectiveness, and in assessing the competitive position of an airport in transportation industry. The primary purpose of this paper is to investigate the operational and financial efficiencies of 22 major airports in the United States and Europe. These airports are divided into three groups based on private ownership (7 British Airport Authority airports), public ownership (8 major United States airports), and a mix of private and public ownership (7 major European Union airports. The detail ownership structures of these airports are presented in Appendix A. Total factor productivity (TFP) model was utilized to measure airport performance in terms of financial and operational efficiencies and to develop a benchmarking tool to identify the areas of strength and weakness. A regression model was then employed to measure the relationship between TFP and ownership structure. Finally a Granger causality test was performed to determine whether ownership structure is a Granger cause of TFP. The results of the analysis presented in this paper demonstrate that there is not a significant relationship between airport TFP and ownership structure. Airport productivity and efficiency is

The first detected airline introductions of yellow fever mosquitoes (Aedes aegypti) to Europe, at Schiphol International airport, the Netherlands.

Science.gov (United States)

Ibañez-Justicia, A; Gloria-Soria, A; den Hartog, W; Dik, M; Jacobs, F; Stroo, A

2017-12-08

airport from flights arriving from overseas, demonstrates the potential risk of international flights to public health as carriers of arthropod vectors of disease. The results strongly suggest that disinsection of containers and their storage compartments inside the aircrafts could contribute to preventing future introductions of mosquito vectors. Invasive mosquito species introduced by aircrafts from overseas could become seasonally established during the warmer months in Europe, or permanently in certain climatically suitable areas for the species, with major consequences for human health.

Business Centre Development Model of Airport Area in Supporting Airport Sustainability in Indonesia

Science.gov (United States)

Setiawan, MI; Surjokusumo, S.; Ma'soem, DM; Johan, J.; Hasyim, C.; Kurniasih, N.; Sukoco, A.; Dhaniarti, I.; Suyono, J.; Sudapet, IN; Nasihien, RD; Mudjanarko, SW; Wulandari, A.; Ahmar, Ansari S.; Wajdi, MBN

2018-01-01

Airport is expected to play the role in enhancing the economic level of the region, especially the local people around the airport. The Aero City concept in developing an airport might also develop a city centreed in the airport that combining airport oriented business development, business actors and local people around the airport area. This study aims to generate development model of business centre at the airports in Indonesia. This is a mixed method based study. The population includes 296 airports under government management, government subsidiary and military. By using stratified random sampling, there were 151 sample airports. The results show that business centre development in the airport area will be related with the airport management and the commercial property (business centre) growth at the airport. Aero City in Indonesia can be developed by partnership system between government and private sector that consists of construction, development, and implementation of commercial property such as hotel, apartment, retail, office, etc. Based on the result of T-Value test, Airport Performance variable predicted to have significant influence on Gross Regional Domestic Product Central Business District performance.

The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression

Science.gov (United States)

He, Chunbo; Mao, Dagan; Hua, Guohua; Lv, Xiangmin; Chen, Xingcheng; Angeletti, Peter C; Dong, Jixin; Remmenga, Steven W; Rodabaugh, Kerry J; Zhou, Jin; Lambert, Paul F; Yang, Peixin; Davis, John S; Wang, Cheng

2015-01-01

The Hippo signaling pathway controls organ size and tumorigenesis through a kinase cascade that inactivates Yes-associated protein (YAP). Here, we show that YAP plays a central role in controlling the progression of cervical cancer. Our results suggest that YAP expression is associated with a poor prognosis for cervical cancer. TGF-α and amphiregulin (AREG), via EGFR, inhibit the Hippo signaling pathway and activate YAP to induce cervical cancer cell proliferation and migration. Activated YAP allows for up-regulation of TGF-α, AREG, and EGFR, forming a positive signaling loop to drive cervical cancer cell proliferation. HPV E6 protein, a major etiological molecule of cervical cancer, maintains high YAP protein levels in cervical cancer cells by preventing proteasome-dependent YAP degradation to drive cervical cancer cell proliferation. Results from human cervical cancer genomic databases and an accepted transgenic mouse model strongly support the clinical relevance of the discovered feed-forward signaling loop. Our study indicates that combined targeting of the Hippo and the ERBB signaling pathways represents a novel therapeutic strategy for prevention and treatment of cervical cancer. PMID:26417066

Convenient Airports: Point of View of the Passengers

Science.gov (United States)

Magri, Adival Aparecido, Jr.; Alves, Claudio Jorge Pinto

2003-01-01

The competition among airlines or among airports aiming at to increase the demand for its services has been more and more incited. Knowledge the perception of the users for the offered services means to meet the customer's needs and expectations in order either to keep the customer, and therefore keep a significant advantage over competitors. The passenger of the air transportation wants rapidity, security and convenience. Convenience can be translated by comfort that the passenger wants for the price that he can pay. In this paper had been identified. as a result of a survey achieved in six Brazilian airports during 2002, the best indicators in the passenger's perception. These indicators among any others were listed m the handbook of Airports Council International (ACI). Distinctive perceptions were observed among passengers with different travel motivations. This survey had been carried through in the airports of Brasilia, Porto Alegre, Salvador. Fortaleza, Curitiba and Bel6m. Considering this survey we can identified the most attractive airport among them. This work is a way to help improve quality of service, in particular, m these six airports of the Brazilian network. The results should be published and made available to all the parties concerned (airport authority, airlines and service providers) and should lead to corrective action when the passenger is not satisfied with the service.

Actual and perceived collision risk for bird strikes at Namibian airports

African Journals Online (AJOL)

At Namibia's two major airports, Hosea Kutako International and Eros (domestic), 117 bird strike collision incidents were recorded between 2006 and 2010. A risk assessment, which included a proposed risk weighting methodology, was conducted at Hosea Kutako and Eros airports, which estimated the probability of an ...

78 FR 28278 - Operating Limitations at New York LaGuardia Airport

Science.gov (United States)

2013-05-14

... between carriers under the same marketing control up to 5 business days after the actual operation. This... of Extension to Order. SUMMARY: This action amends the Order Limiting Operations at New York... Rule on Slot Management and Transparency for LaGuardia Airport, John F. Kennedy International Airport...

A plume-in-grid approach to characterize air quality impacts of aircraft emissions at the Hartsfield–Jackson Atlanta International Airport

Directory of Open Access Journals (Sweden)

J. Rissman

2013-09-01

Full Text Available This study examined the impacts of aircraft emissions during the landing and takeoff cycle on PM2.5 concentrations during the months of June and July 2002 at the Hartsfield–Jackson Atlanta International Airport. Primary and secondary pollutants were modeled using the Advanced Modeling System for Transport, Emissions, Reactions, and Deposition of Atmospheric Matter (AMSTERDAM. AMSTERDAM is a modified version of the Community Multiscale Air Quality (CMAQ model that incorporates a plume-in-grid process to simulate emissions sources of interest at a finer scale than can be achieved using CMAQ's model grid. Three fundamental issues were investigated: the effects of aircraft on PM2.5 concentrations throughout northern Georgia, the differences resulting from use of AMSTERDAM's plume-in-grid process rather than a traditional CMAQ simulation, and the concentrations observed in aircraft plumes at subgrid scales. Comparison of model results with an air quality monitor located in the vicinity of the airport found that normalized mean bias ranges from −77.5% to 6.2% and normalized mean error ranges from 40.4% to 77.5%, varying by species. Aircraft influence average PM2.5 concentrations by up to 0.232 μg m−3 near the airport and by 0.001–0.007 μg m−3 throughout the Atlanta metro area. The plume-in-grid process increases concentrations of secondary PM pollutants by 0.005–0.020 μg m−3 (compared to the traditional grid-based treatment but reduces the concentration of non-reactive primary PM pollutants by up to 0.010 μg m−3, with changes concentrated near the airport. Examination of subgrid-scale results indicates that median aircraft contribution to grid cells is higher than median puff concentration in the airport's grid cell and outside of a 20 km × 20 km square area centered on the airport, while in a 12 km × 12 km square ring centered on the airport, puffs have median concentrations over an order of magnitude higher than aircraft

A Comparative Study of the Application of Passive Defense Strategies from the Perspective of Urban Design at International Airports: International Airports of Ben-Gurion, Munich and Singapore Changi

Directory of Open Access Journals (Sweden)

Hoda Ghanbarpour

2017-06-01

Full Text Available Billions are spent every year to construct vital infrastructures around the world. On the other hand, we witness terrorist crimes and the killing of innocent people and causing serious physical and psychological damages to them every day in every corner of the world. Unfortunately, today this trend has not been stopped and likely will continue. So, due to the fact that the most important issue in urban design is human and the most important goal is to create safe and stable places for them, it can be concluded that in critical infrastructure such as airports, which are a priority to strategies to deal with terrorist threats, public areas vulnerabilities against terrorist threats have to be investigated to understand the weaknesses of the target infrastructures. So, determining its attractiveness for the invasion, civil defense measures can be taken to reduce vulnerability. In this regard, urban design principles should be applied to reduce the blast effects and to minimize the damage in the public areas of airports. In this study, by implementing an analytical-descriptive methodology, we attempt to identify urban design guidelines resistant to terrorist bombings in public areas of airport environments. The findings of this study show that in achieving terrorist blast-resistant urban design, deployment of strategies in the field of building components, atmosphere, design, and urban landscape will reduce the vulnerability of airports.

YAP Inhibition by Resveratrol via Activation of AMPK Enhances the Sensitivity of Pancreatic Cancer Cells to Gemcitabine

Directory of Open Access Journals (Sweden)

Zhengdong Jiang

2016-09-01

Full Text Available Resveratrol, a natural polyphenol present in most plants, inhibits the growth of numerous cancers both in vitro and in vivo. Aberrant expression of YAP has been reported to activate multiple growth-regulatory pathways and confer anti-apoptotic abilities to many cancer cells. However, the role of resveratrol in YES-activated protein (YAP expression and that of YAP in pancreatic cancer cells’ response to gemcitabine resistance remain elusive. In this study, we found that resveratrol suppressed the proliferation and cloning ability and induced the apoptosis of pancreatic cancer cells. These multiple biological effects might result from the activation of AMP-activation protein kinase (AMPK (Thr172 and, thus, the induction of YAP cytoplasmic retention, Ser127 phosphorylation, and the inhibition of YAP transcriptional activity by resveratrol. YAP silencing by siRNA or resveratrol enhanced the sensitivity of gemcitabine in pancreatic cancer cells. Taken together, these findings demonstrate that resveratrol could increase the sensitivity of pancreatic cancer cells to gemcitabine by inhibiting YAP expression. More importantly, our work reveals that resveratrol is a potential anticancer agent for the treatment of pancreatic cancer, and YAP may serve as a promising target for sensitizing pancreatic cancer cells to chemotherapy.

Aeronautical Mobile Airport Communications System (AeroMACS)

Science.gov (United States)

Budinger, James M.; Hall, Edward

2011-01-01

To help increase the capacity and efficiency of the nation s airports, a secure wideband wireless communications system is proposed for use on the airport surface. This paper provides an overview of the research and development process for the Aeronautical Mobile Airport Communications System (AeroMACS). AeroMACS is based on a specific commercial profile of the Institute of Electrical and Electronics Engineers (IEEE) 802.16 standard known as Wireless Worldwide Interoperability for Microwave Access or WiMAX (WiMax Forum). The paper includes background on the need for global interoperability in air/ground data communications, describes potential AeroMACS applications, addresses allocated frequency spectrum constraints, summarizes the international standardization process, and provides findings and recommendations from the world s first AeroMACS prototype implemented in Cleveland, Ohio, USA.

Transcriptional integration of mitogenic and mechanical signals by Myc and YAP.

Science.gov (United States)

Croci, Ottavio; De Fazio, Serena; Biagioni, Francesca; Donato, Elisa; Caganova, Marieta; Curti, Laura; Doni, Mirko; Sberna, Silvia; Aldeghi, Deborah; Biancotto, Chiara; Verrecchia, Alessandro; Olivero, Daniela; Amati, Bruno; Campaner, Stefano

2017-10-15

Mammalian cells must integrate environmental cues to determine coherent physiological responses. The transcription factors Myc and YAP-TEAD act downstream from mitogenic signals, with the latter responding also to mechanical cues. Here, we show that these factors coordinately regulate genes required for cell proliferation. Activation of Myc led to extensive association with its genomic targets, most of which were prebound by TEAD. At these loci, recruitment of YAP was Myc-dependent and led to full transcriptional activation. This cooperation was critical for cell cycle entry, organ growth, and tumorigenesis. Thus, Myc and YAP-TEAD integrate mitogenic and mechanical cues at the transcriptional level to provide multifactorial control of cell proliferation. © 2017 Croci et al.; Published by Cold Spring Harbor Laboratory Press.

Airport industry connectivity report: 2004-2014

NARCIS (Netherlands)

Burghouwt, G.; Lieshout, R.

2014-01-01

Airport connectivity is an increasingly discussed topic in European policy circles. With good reason. Connectivity is closely connected with productivity, economic growth and international trade. And with the centre of global economic activity shifting eastward, it is essential that Europe remains

Yap1 is dispensable for self-renewal but required for proper differentiation of mouse embryonic stem (ES) cells.

Science.gov (United States)

Chung, HaeWon; Lee, Bum-Kyu; Uprety, Nadima; Shen, Wenwen; Lee, Jiwoon; Kim, Jonghwan

2016-04-01

Yap1 is a transcriptional co-activator of the Hippo pathway. The importance of Yap1 in early cell fate decision during embryogenesis has been well established, though its role in embryonic stem (ES) cells remains elusive. Here, we report that Yap1 plays crucial roles in normal differentiation rather than self-renewal of ES cells. Yap1-depleted ES cells maintain undifferentiated state with a typical colony morphology as well as robust alkaline phosphatase activity. These cells also retain comparable levels of the core pluripotent factors, such as Pou5f1 and Sox2, to the levels in wild-type ES cells without significant alteration of lineage-specific marker genes. Conversely, overexpression of Yap1 in ES cells promotes nuclear translocation of Yap1, resulting in disruption of self-renewal and triggering differentiation by up-regulating lineage-specific genes. Moreover, Yap1-deficient ES cells show impaired induction of lineage markers during differentiation. Collectively, our data demonstrate that Yap1 is a required factor for proper differentiation of mouse ES cells, while remaining dispensable for self-renewal. © 2016 The Authors.

Study of noise inside the peshawar airport

International Nuclear Information System (INIS)

Khan, M.; Khan, A.R.; Shah, J.; Noor, S.; Aslam, T.

2007-01-01

The paper deals with the noise-study conducted at five different locations within the vicinity of International Airport, Peshawar (Pakistan). The sites selected for this study were Apron, Concourse Hall, Cargo Shed, Car Parking and Utility Block. Noise-levels were recorded during 'landing' and 'taking off' of aircrafts of six international, flights, operating from this Airport. The average noise levels at Apron, Concourse Hall, Cargo Shed, Car Parking and Utility Block were found to be in the range of 87.2-90.3, 77.7-82.0, 82.6-87.5, 0.1-84.5 and 85.0-85.8 dB (A) respectively. The results are discussed, with reference to permissible occupational noise-exposure limits. The health-impacts due to higher noise-level and their possible remedial measures have also been discussed. (author)

Acquisition of omptin reveals cryptic virulence function of autotransporter YapE in Yersinia pestis

Science.gov (United States)

Pennington, Jarrod; Miller, Virginia L.

2013-01-01

SUMMARY Autotransporters, the largest family of secreted proteins in Gram negative bacteria, perform a variety of functions, including adherence, cytotoxicity, and immune evasion. In Yersinia pestis the autotransporter YapE has adhesive properties and contributes to bubonic infection of the mouse model. Here, we demonstrate that omptin cleavage of Y. pestis YapE is required to mediate bacterial aggregation and adherence to eukaryotic cells. We demonstrate that omptin cleavage is specific for the Y. pestis and Y. pseudotuberculosis YapE orthologs but is not conserved in the Y. enterocolitica protein. We also show that cleavage of YapE occurs in Y. pestis but not in the enteric Yersinia species, and requires the omptin Pla (plasminogen activator protease), which is encoded on the Y. pestis-specific plasmid pPCP1. Together, these data show that post-translation modification of YapE appears to be specific to Y. pestis, was acquired along with the acquisition of pPCP1 during the divergence of Y. pestis from Y. pseudotuberculosis, and are the first evidence of a novel mechanism to regulate bacterial adherence. PMID:23701256

Forest pathology in Yap, Palau, Pohnpei, Kosrae, Guam and Saipan, Sept. 2013

Science.gov (United States)

Phil Cannon

2014-01-01

In September of 2013, an opportunity was seized by the Regional Forest Pathologist to do some work on the following islands in Micronesia and the Marianas: Yap, Palau, Guam, Saipan, Pohnpei, and Kosrae. The principle justification for doing the work at this time was that satellite images showed large areas of dead mangroves on Yap (Liu, pers. com). Many...

Management strategies for regional airports: A study applied to -Lleida-Alguaire airport

Directory of Open Access Journals (Sweden)

Natalia Daries-Ramon

2017-05-01

Full Text Available Purpose: The main objective of this article is to analyse the current situation at Lleida-Alguaire Airport and propose possible actions to increase its profitability. Design/methodology/approach: This study presents the method as a research tool applied to regional airports, in particular, Lleida-Alguaire Airport. Findings: The study shows the importance of air transport and the current situation of Spanish airports, specifically in Catalonia, exposing the main air traffic imbalances between different airports and their effect on tourism. Finally, it describes and analyses the situation of Lleida-Alguaire Airport. Practical implications: Some actions in relation with aeronautical traffic are presented in order to improve and increase the efficiency of the system. Originality/value: This article is one of the first works to focus on regional airports and it seeks ways to improve their economic and social efficiency.

YAP regulates the expression of Hoxa1 and Hoxc13 in mouse and human oral and skin epithelial tissues.

Science.gov (United States)

Liu, Ming; Zhao, Shuangyun; Lin, Qingjie; Wang, Xiu-Ping

2015-04-01

Yes-associated protein (YAP) is a Hippo signaling transcriptional coactivator that plays pivotal roles in stem cell proliferation, organ size control, and tumor development. The downstream targets of YAP have been shown to be highly context dependent. In this study, we used the embryonic mouse tooth germ as a tool to search for the downstream targets of YAP in ectoderm-derived tissues. Yap deficiency in the dental epithelium resulted in a small tooth germ with reduced epithelial cell proliferation. We compared the gene expression profiles of embryonic day 14.5 (E14.5) Yap conditional knockout and YAP transgenic mouse tooth germs using transcriptome sequencing (RNA-Seq) and further confirmed the differentially expressed genes using real-time PCR and in situ hybridization. We found that YAP regulates the expression of Hoxa1 and Hoxc13 in oral and dental epithelial tissues as well as in the epidermis of skin during embryonic and adult stages. Sphere formation assay suggested that Hoxa1 and Hoxc13 are functionally involved in YAP-regulated epithelial progenitor cell proliferation, and chromatin immunoprecipitation (ChIP) assay implies that YAP may regulate Hoxa1 and Hoxc13 expression through TEAD transcription factors. These results provide mechanistic insights into abnormal YAP activities in mice and humans. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Airport Capital Improvement Plan : stewardship for airport development

Science.gov (United States)

1997-09-01

This document summarizes efforts of the Federal Aviation Administration (FAA) Office : of the Associate Administrator for Airports to implement the concept of Airport Capital : Improvement Planning (ACIP). It is based on the experiences of the FAA's ...

RUNX1 and RUNX3 protect against YAP-mediated EMT, stem-ness and shorter survival outcomes in breast cancer

Science.gov (United States)

Kulkarni, Madhura; Tan, Tuan Zea; Syed Sulaiman, Nurfarhanah Bte; Lamar, John M.; Bansal, Prashali; Cui, Jianzhou; Qiao, Yiting; Ito, Yoshiaki

2018-01-01

Hippo pathway target, YAP has emerged as an important player in solid tumor progression. Here, we identify RUNX1 and RUNX3 as novel negative regulators of oncogenic function of YAP in the context of breast cancer. RUNX proteins are one of the first transcription factors identified to interact with YAP. RUNX1 or RUNX3 expression abrogates YAP-mediated pro-tumorigenic properties of mammary epithelial cell lines in an interaction dependent manner. RUNX1 and RUNX3 inhibit YAP-mediated migration and stem-ness properties of mammary epithelial cell lines by co-regulating YAP-mediated gene expression. Analysis of whole genome expression profiles of breast cancer samples revealed significant co-relation between YAP–RUNX1/RUNX3 expression levels and survival outcomes of breast cancer patients. High RUNX1/RUNX3 expression proved protective towards YAP-dependent patient survival outcomes. High YAP in breast cancer patients’ expression profiles co-related with EMT and stem-ness gene signature enrichment. High RUNX1/RUNX3 expression along with high YAP reflected lower enrichment of EMT and stem-ness signatures. This antagonistic activity of RUNX1 and RUNX3 towards oncogenic function of YAP identified in mammary epithelial cells as well as in breast cancer expression profiles gives a novel mechanistic insight into oncogene–tumor suppressor interplay in the context of breast cancer progression. The novel interplay between YAP, RUNX1 and RUNX3 and its significance in breast cancer progression can serve as a prognostic tool to predict cancer recurrence. PMID:29581836

75 FR 70081 - Notice of Release From Federal Grant Assurance Obligations for Tucson International Airport...

Science.gov (United States)

2010-11-16

... property will be sold for its fair market value and the proceeds deposited in the airport account. The... market value and the sale proceeds will be deposited in the airport account. Continued use of the...

Concorde noise-induced building vibrations: International Airport Dulles. [studies by Langley Research Center

Science.gov (United States)

Mayes, W. H.; Scholl, H. F.; Stephens, D. G.; Holliday, B. G.; Deloach, R.; Finley, T. D.; Holmes, H. K.; Lewis, R. B.; Lynch, J. W.

1977-01-01

A series of studies were conducted to assess the noise-induced building vibrations associated with Concorde operations. The vibration levels of windows, walls, and floors were measured along with the associated noise levels of Concorde, subsonic aircraft and some nonaircraft events. Test sites included Sully Plantation which is adjacent to Dulles International Airport and three residential homes located in Montgomery County, Maryland. The measured vibration response levels due to Concorde operations were found to be: (1) higher than the levels due to other aircraft, (2) less than the levels due to certain household events which involve direct impulsive loading such as door and window closing, (3) less than criteria levels for building damage, and (4) comparable to levels which are perceptible to people.

Toxicity and chemical analyses of airport runoff waters in Poland.

Science.gov (United States)

Sulej, Anna Maria; Polkowska, Zaneta; Wolska, Lidia; Cieszynska, Monika; Namieśnik, Jacek

2014-05-01

The aim of this study was to assess the ecotoxicological effects of various compounds in complex airport effluents using a chemical and ecotoxicological integrated strategy. The present work deals with the determination of sum of PCBs, PAHs, pesticides, cations, anions, phenols, anionic, cationic, non-ionic detergents, formaldehyde and metals--as well as TOC and conductivity--in runoff water samples collected from 2009 to 2011 at several locations on two Polish international airports. Two microbiotests (Vibrio fischeri bacteria and the crustacean Thamnocephalus platyurus) have been used to determine the ecotoxicity of airport runoff waters. The levels of many compounds exceeded several or even several tens of times the maximum permissible levels. Analysis of the obtained data shows that samples that displayed maximum toxicity towards the bioindicators Vibrio fischeri were not toxic towards Thamnocephalus platyurus. Levels of toxicity towards T. platyurus are strongly correlated with pollutants that originate from the technological operations related to the maintenance of airport infrastructure. The integrated (chemical-ecotoxicological) approach to environmental contamination assessment in and around airports yields extensive information on the quality of the environment. These methodologies can be then used as tools for tracking the environmental fate of these compounds and for assessing the environmental effect of airports. Subsequently, these data will provide a basis for airport infrastructure management.

Purchase motivators in Brazilian airports: A typology of airports consumers.

Directory of Open Access Journals (Sweden)

Jorge Brantes Ferreira

2012-04-01

Full Text Available In order to enhance their revenue streams, airports have increasingly assumed the role of commercial hubs. However, they differ from traditional retailers because of the atmospheric and psychological issues inherent to the act of traveling. Given the scarcity of studies aimed at understanding the motivators of airport purchases in Brazil, this study seeks to investigate the shopping behavior of Brazilian passengers, researching buying motivations at airports. To this end, 157 Brazilian passengers at Santos Dumont airport (Rio de Janeiro were invited to participate in a survey. The survey instrument was developed based on the variables and constructs suggested by Geuens, Vantomme e Brengman (2004.The results revealed four dimensions of buying motivation: two of them linked to the characteristics of an airport – “Atmospheric” and “Airport Related” - and two others linked to traditional buying behavior – “Social” and “Functional”. Based on the revealed motivational dimensions, the Brazilian passengers were classified in four different groups: Interactive Consumer, Self-centered Consumer, Traditional Consumer and Apathetic/Indifferent Consumer.

Radioactivity level of airplane to Guangzhou Baiyun international airport during the Fukushima Daiichi nuclear power plant accident

International Nuclear Information System (INIS)

Song Haiqing; Chen Wentao; Cheng Xiaobo; Liao Tong; Deng Fei; Chen Fuliang; Zhang Yanjin; Li Lingjuan; Liang Guiyuan; Wu Guibiao

2014-01-01

The radioactivity level of airplanes to Guangzhou Baiyun International Airport (GBIAC) during the Fukushima Daiichi nuclear power plant accident was monitored by Guangdong Environmental Radiation Monitoring Center (GERC) on March 15 and 16, 2011. The artificial radionuclide "1"3"1I, "1"3"4Cs, "1"3"7Cs, "l"3"6Cs, "1"3"2I, "1"3"2Te were detected in the wipe samples of the outer surface of airplanes from Japan to GBIAC. The radioactivity ration of "1"3"7Cs/"1"3"4Cs was calculated as (1.12 ± 0.06) in the wipe samples, which similar to the result in the wipe sample of the outer surface of airplanes from Japan to Hangzhou airport obtained by Zhejiang Province Environmental Radiation Monitoring Center (l.lO ± 0.08), but slightly higher than results in the aerosol monitoring at Guangzhou (0.99 ± 0.30) and Shenzhen (0.94 ± 0.30) by GERC, the data (0.83) published by Japan Nuclear and Industrial Safety Agency (NISA) and the result (1.00 ± 0.13) measured by Tokyo Electric Power Company. A slight radioactive contamination was detected on the surface of outer airplanes and internal cabin. The practice suggested that the wipe sample of the outer surface of airplane was a fast , simple and sensitive approach for emergency monitoring of radioactive contamination. (authors)

Evaluation of a New Strategy for Attending Takeoffs and Landings to Reduce Aircraft Operating Costs and Passenger Delays at the Mexico City International Airport

Directory of Open Access Journals (Sweden)

Herrera-García Alfonso

2014-01-01

Full Text Available The objective of this research was to evaluate a strategy for attending the takeoffs and landings at a congested airport, in order to reduce aircraft operating costs and passenger delay times. The continuous growth of air transport activity has created congestion at major airports worldwide, this situation produces increases in the aircraft operating costs and passenger discomfort. In the strategy evaluated the traditional rule for attending to aircraft, on a first-come-first-served basis, was substituted with a sequence that reduces operating costs and passenger delays. In order to perform this evaluation a discrete-event simulation model was developed for the Mexico City International Airport. Results showed that it is possible to obtain significant benefits if the proposed strategy is applied, an annual benefit of around 28.6 million pesos could be achieved.

Geometrik Yapıların İnşasında Pergel ve Çizgecin Kullanımı

OpenAIRE

Erduran, Ayten; Yeşildere, Sibel

2010-01-01

Bu yapıda üç matematik öğretinin pergel ve çizgeçmenin geometrik yapıları süreçleri incelenmektedir. Öğretmenlerin geometri yapı yapımı ve ilgili dersleri video kamera ile kaydedilmiş ve derslerdeki öğretmen-öğrenci-araç üçlüsü arasındaki etkileşim incelenmiştir. Ders Kitaplığı içeren öğretmenlerle görüşmeler yapıldı. Çalışmada üç matematik öğretmeninin pergel ve çizgeci geometrik yapılar yapı mühendisliği. Araştırma pergel ve çizgeçle geometrik yapıların inşasına ezbere bir anlayışla öğretme...

Assessing coastal flood risk and sea level rise impacts at New York City area airports

Science.gov (United States)

Ohman, K. A.; Kimball, N.; Osler, M.; Eberbach, S.

2014-12-01

Flood risk and sea level rise impacts were assessed for the Port Authority of New York and New Jersey (PANYNJ) at four airports in the New York City area. These airports included John F. Kennedy International, LaGuardia, Newark International, and Teterboro Airports. Quantifying both present day and future flood risk due to climate change and developing flood mitigation alternatives is crucial for the continued operation of these airports. During Hurricane Sandy in October 2012 all four airports were forced to shut down, in part due to coastal flooding. Future climate change and sea level rise effects may result in more frequent shutdowns and disruptions in travel to and from these busy airports. The study examined the effects of the 1%-annual-chance coastal flooding event for present day existing conditions and six different sea level rise scenarios at each airport. Storm surge model outputs from the Federal Emergency Management Agency (FEMA) provided the present day storm surge conditions. 50th and 90thpercentile sea level rise projections from the New York Panel on Climate Change (NPCC) 2013 report were incorporated into storm surge results using linear superposition methods. These projections were evaluated for future years 2025, 2035, and 2055. In addition to the linear superposition approach for storm surge at airports where waves are a potential hazard, one dimensional wave modeling was performed to get the total water level results. Flood hazard and flood depth maps were created based on these results. In addition to assessing overall flooding at each airport, major at-risk infrastructure critical to the continued operation of the airport was identified and a detailed flood vulnerability assessment was performed. This assessment quantified flood impacts in terms of potential critical infrastructure inundation and developed mitigation alternatives to adapt to coastal flooding and future sea level changes. Results from this project are advancing the PANYNJ

Berlin Brandenburg International (BER: planning and implementation of a concrete supply chain for the airport construction site

Directory of Open Access Journals (Sweden)

Guido Riedel

2012-12-01

Full Text Available Background: With the decision to extend the airport Berlin-Schönefeld to the new airport Berlin Brandenburg International (BER in 2006, a construction of superlatives has emerged. One of the biggest challenges was the supply of around 2.5 million cubic meters of high quality concrete that had to be produced for the construction of the airport. Due to the scale of this enterprise as well as its environment, the logistic solution of raw material supply has to be found.       Method: The planning of the concrete supply chain for the airport construction site BER had to be carried out with two major goals: the stability of the supply chain to assure that the demands of the construction site are met and delays are prevented, as well as assurance of the high quality standards of the concrete production and to avoid an alkali silica reaction and the resulting unavoidable disaggregation of the concrete. External effects, such as the carbon dioxide emission and the effect of the supply chain on adjoining residents were key factors that had to be integrated in a holistic supply chain concept.  The principle underlying method is an analysis of limiting conditions for two approaches: a centralized supply chain with on-site concrete factory and upstream transport of raw materials versus a decentralized supply chain with off-site factories and downstream transport of ready-mixed concrete. Results: The analysis of constraints and the effects on key requirements of the concrete supply chain for the BER airport construction site lead to the installation of the most modern concrete plant in Europe. The benefits of a centralized supply chain are significant. On one hand, the high quality standards can be met with the on-site mixture of the concrete and centralized quality assurance, on the other hand, the majority of the supply traffic for the construction site was moved from the road to train-bound logistics, meeting the emission requirements of the

Indigenous Fallow Management on Yap Island

Science.gov (United States)

M.V.C. Falanruw; Francis Ruegorong

2002-01-01

On Yap Island, indigenous management of the fallow in shifting agriculture has resulted in the development of site-stable taro patch and tree garden agroforestry systems. These systems are relatively sustainable and supportive of household economies , with some surplus for local market sales. however, a broad range of crops whose harvest is complementary to those...

Hippo Signaling Regulates Pancreas Development through Inactivation of Yap

Science.gov (United States)

Day, Caroline E.; Boerner, Brian P.; Johnson, Randy L.; Sarvetnick, Nora E.

2012-01-01

The mammalian pancreas is required for normal metabolism, with defects in this vital organ commonly observed in cancer and diabetes. Development must therefore be tightly controlled in order to produce a pancreas of correct size, cell type composition, and physiologic function. Through negative regulation of Yap-dependent proliferation, the Hippo kinase cascade is a critical regulator of organ growth. To investigate the role of Hippo signaling in pancreas biology, we deleted Hippo pathway components in the developing mouse pancreas. Unexpectedly, the pancreas from Hippo-deficient offspring was reduced in size, with defects evident throughout the organ. Increases in the dephosphorylated nuclear form of Yap are apparent throughout the exocrine compartment and correlate with increases in levels of cell proliferation. However, the mutant exocrine tissue displays extensive disorganization leading to pancreatitis-like autodigestion. Interestingly, our results suggest that Hippo signaling does not directly regulate the pancreas endocrine compartment as Yap expression is lost following endocrine specification through a Hippo-independent mechanism. Altogether, our results demonstrate that Hippo signaling plays a crucial role in pancreas development and provide novel routes to a better understanding of pathological conditions that affect this organ. PMID:23071096

YAP1 regulates prostate cancer stem cell-like characteristics to promote castration resistant growth

DEFF Research Database (Denmark)

Jiang, Ning; Ke, Binghu; Hjort-Jensen, Kim

2017-01-01

Castration resistant prostate cancer (CRPC) is a stage of relapse that arises after various forms of androgen ablation therapy (ADT) and causes significant morbidity and mortality. However, the mechanism underlying progression to CRPC remains poorly understood. Here, we report that YAP1, which...... is negatively regulated by AR, influences prostate cancer (PCa) cell self-renewal and CRPC development. Specifically, we found that AR directly regulates the methylation of YAP1 gene promoter via the formation of a complex with Polycomb group protein EZH2 and DNMT3a. In normal conditions, AR recruits EZH2......-differentiation of PCa cells to stem/progenitor-like cells (PCSC), which potentially contribute to disease recurrence. Finally, the knock down of YAP1 expression or the inhibition of YAP1 function by Verteporfin in TRAMP prostate cancer mice significantly suppresses tumor recurrence following castration. In conclusion...

Examining Passenger Flow Choke Points at Airports Using Discrete Event Simulation

Science.gov (United States)

Brown, Jeremy R.; Madhavan, Poomima

2011-01-01

The movement of passengers through an airport quickly, safely, and efficiently is the main function of the various checkpoints (check-in, security. etc) found in airports. Human error combined with other breakdowns in the complex system of the airport can disrupt passenger flow through the airport leading to lengthy waiting times, missing luggage and missed flights. In this paper we present a model of passenger flow through an airport using discrete event simulation that will provide a closer look into the possible reasons for breakdowns and their implications for passenger flow. The simulation is based on data collected at Norfolk International Airport (ORF). The primary goal of this simulation is to present ways to optimize the work force to keep passenger flow smooth even during peak travel times and for emergency preparedness at ORF in case of adverse events. In this simulation we ran three different scenarios: real world, increased check-in stations, and multiple waiting lines. Increased check-in stations increased waiting time and instantaneous utilization. while the multiple waiting lines decreased both the waiting time and instantaneous utilization. This simulation was able to show how different changes affected the passenger flow through the airport.

Rural Airports

Data.gov (United States)

Department of Transportation — The Rural Airports database is the list of rural airports compiled annually by BTS for the Treasury Department/IRS. It is used by airlines to assist in establishing...

75 FR 55401 - Notice of Intent To Rule on Request To Release Airport Property at the Dallas/Fort Worth...

Science.gov (United States)

2010-09-10

... To Release Airport Property at the Dallas/Fort Worth International Airport, DFW Airport, TX AGENCY... airport property. SUMMARY: The FAA proposes to rule and invite public comment on the request for permanent... H. Ford Aviation Investment Reform Act for the 21st Century (AIR 21). DATES: Comments must be...

78 FR 9105 - Notice of Intent To Rule on Request To Release Airport Property at the Dallas/Fort Worth...

Science.gov (United States)

2013-02-07

... To Release Airport Property at the Dallas/Fort Worth International Airport, DFW Airport, TX AGENCY... Airport Property. SUMMARY: The FAA proposes to rule and invite public comment on the request for permanent... H. Ford Aviation Investment Reform Act for the 21st Century (AIR 21). DATES: Comments must be...

Overexpression of the transcription factor Yap1 modifies intracellular redox conditions and enhances recombinant protein secretion

Directory of Open Access Journals (Sweden)

Marizela Delic

2014-10-01

Full Text Available Oxidative folding of secretory proteins in the endoplasmic reticulum (ER is a redox active process, which also impacts the redox conditions in the cytosol. As the transcription factor Yap1 is involved in the transcriptional response to oxidative stress, we investigate its role upon the production of secretory proteins, using the yeast Pichia pastoris as model, and report a novel important role of Yap1 during oxidative protein folding. Yap1 is needed for the detoxification of reactive oxygen species (ROS caused by increased oxidative protein folding. Constitutive co-overexpression of PpYAP1 leads to increased levels of secreted recombinant protein, while a lowered Yap1 function leads to accumulation of ROS and strong flocculation. Transcriptional analysis revealed that more than 150 genes were affected by overexpression of YAP1, in particular genes coding for antioxidant enzymes or involved in oxidation-reduction processes. By monitoring intracellular redox conditions within the cytosol and the ER using redox-sensitive roGFP1 variants, we could show that overexpression of YAP1 restores cellular redox conditions of protein-secreting P. pastoris by reoxidizing the cytosolic redox state to the levels of the wild type. These alterations are also reflected by increased levels of oxidized intracellular glutathione (GSSG in the YAP1 co-overexpressing strain. Taken together, these data indicate a strong impact of intracellular redox balance on the secretion of (recombinant proteins without affecting protein folding per se. Re-establishing suitable redox conditions by tuning the antioxidant capacity of the cell reduces metabolic load and cell stress caused by high oxidative protein folding load, thereby increasing the secretion capacity.

Chemical Characteristics of Seawater and Sediment in the Yap Trench

Science.gov (United States)

Ding, H.; Sun, C.; Yang, G.

2017-12-01

In June 2016, seawater samples at sediment-seawater interface and sediment samples were collected by the he Jiaolong, China's manned submersible, at four sampling sites located in the Yap Trench. Seawater samples from different depths of the trench were also collected by CTD. Chemical parameters, including pH, alkanility, concentrations of dissolved inorganic carbon, dissolved and total organic carbon, methane, dimethylsulfoniopropionate, nutrients, carbohydrates, and amino acids were analyzed in the seawater samples. Concentrations of total organic carbon, six constant elements and nine trace elements were determined in the sediment samples. All the vertical profiles of the chemical parameters in the seawater have unique characteristics. Our resluts also showed that the carbonate compensation depth (CCD) was between 4500 m and 5000 m in the trench. The hadal sediment at 6500 m depth under the CCD line was siliceous ooze favored for the burial of orgaic carbon, attributed to accumulation of surface sediment by gravity flow. The abyssal sediment at the 4500 m depth was calcareous ooze. Various microfossils, such as discoasters and diatoms, were identified in different sediment layers of the sediment samples.Based on the ratios of Fe/Al and Ti/Al, and the correlation between different elements, the sediment in the Yap Trench were derived from biogenic, terrestrial, volcanic and autogenic sources. The ratios of Ni/Co and V/Cr showed that the deposition environment of the trench should be oxidative, arributed to inflow of the Antractic bottom oxygen-rich seawater.The high concentraiont of Ca in the sediment from the station 371-Yap-S02 below 4 cm depth indicated that there was no large-scale volcanic eruption in the research area and the volcanic materials in the sediment might orginated from the Mariana Volcanic Arc, and the Carolyn Ridge has been slowly sinking on the east side of the trench due to plate subduction. This study is the first systematic study of

Nuclear localization of the transcriptional coactivator YAP is associated with invasive lobular breast cancer

NARCIS (Netherlands)

Vlug, E.J.; Ven, R.A. van de; Vermeulen, J.F.; Bult, P.; Diest, P.J. van; Derksen, P.W.B.

2013-01-01

BACKGROUND: Yes Associated Protein (YAP) has been implicated in the control of organ size by regulating cell proliferation and survival. YAP is a transcriptional coactivator that controls cellular responses through interaction with TEAD transcription factors in the nucleus, while its transcriptional

Runway Incursion Prevention System: Demonstration and Testing at the Dallas/Fort Worth International Airport

Science.gov (United States)

Jones, Denise R.; Quach, Cuong C.; Young, Steven D.

2007-01-01

A Runway Incursion Prevention System (RIPS) was tested at the Dallas-Ft. Worth International Airport (DFW) in October 2000. The system integrated airborne and ground components to provide both pilots and controllers with enhanced situational awareness, supplemental guidance cues, a real-time display of traffic information, and warning of runway incursions in order to prevent runway incidents while also improving operational capability. A series of test runs was conducted using NASA s Boeing 757 research aircraft and a test van equipped to emulate an incurring aircraft. The system was also demonstrated to over 100 visitors from the aviation community. This paper gives an overview of the RIPS, DFW flight test activities, and quantitative and qualitative results of the testing.

77 FR 4394 - Release of Airport Property: Orlando Executive Airport, Orlando, FL

Science.gov (United States)

2012-01-27

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Release of Airport Property: Orlando Executive Airport, Orlando, FL AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Request for... 12.4 acres at the Orlando Executive Airport, Orlando, FL from the conditions, release certain...

YAP:Ce and CsI(Tl) detectors for dielectronic recombination experiment at the CSRm

International Nuclear Information System (INIS)

Wen, W.Q.; Ma, X.; Xu, W.Q.; Meng, L.J.; Zhu, X.L.; Gao, Y.; Wang, S.L.; Zhang, P.J.; Zhao, D.M.; Liu, H.P.; Zhu, L.F.; Yang, X.D.; Li, J.; Ma, X.M.; Yan, T.L.; Yang, J.C.; Yuan, Y.J.; Xia, J.W.; Xu, H.S.; Xiao, G.Q.

2013-01-01

Highlights: • YAP:Ce and CsI(Tl) scintillation detectors are developed to detect heavy ions at the storage ring. • A high count rate of ∼10 7 s −1 is obtained with the YAP:Ce detector for heavy ion detection. • YAP:Ce detector shows good performance for DR experiment with 3.7 MeV/u 112 Sn 35+ . -- Abstract: The storage ring CSRm in Lanzhou provides good possibilities for electron-ion collision studies with cooled ion beams. To carry on the recombination experiment at the CSRm, a scintillation detector CsI(Tl) to detect the recombined ions was developed and tested. In addition, a YAP:Ce detector has been developed and installed at CSRm and capability of handling a high count rate of ∼10 7 s −1 has been obtained which is sufficient for the future dielectronic recombination experiment at the CSRm. The comparison of the characteristics of these two detectors is presented

Spatial relationships and movement patterns of the air cargo industry in airport regions

Directory of Open Access Journals (Sweden)

Petrus J. van V. Coetzee

2017-05-01

Full Text Available Background: During the past few years, with the increase in air traffic and the expansion of airports, very few industries had such a large spatial development and movement impact as that of airport-related clusters or airport regions. Although much research was done on the various impacts of the airport industry, very little research was done on the air cargo industry in airport regions. Objectives: This article specifically explored the unique spatial relationships, impacts, trends and movement patterns of the air cargo industry within a typical airport region. Method: The article focused on the OR Tambo International Airport in Gauteng, South Africa, as a case study and was informed by an extensive quantitative spatial and land use analysis and modelling of the study area. Results: The article presented findings and insights on the movement patterns and relationships between (1 the airport facility and (2 the spatial configuration of air cargo industries in the particular airport region. These findings also provided some framework for a possible spatial model and guideline that could assist in steering and managing development and movement patterns in airport regions. Conclusion: The article provided new insights and understanding on the spatial dynamics of airport regions and the air cargo industry, ultimately addressing some gaps in this knowledge field. The article in the end highlighted the need for a different and novel approach to the planning and management of the air cargo industry in airport regions and a basis for further research.

AIRPORT NOISE CHARGES AND LOCAL COMMUNITIES: APPLICATION TO REGIONAL AIRPORTS

Directory of Open Access Journals (Sweden)

LUCA MANTECCHINI

2016-11-01

Full Text Available There have always been conflicts among airports and local communities due to the aeronautical noise generated by airport operations. In fact, this is a factor that - if not properly managed - could severely cut down the growth of air traffic in an airport with direct effects on the economic and territorial system. Beside this, in the last decade the critical issues related to the impact of aeronautical noise on airport operations have greatly reduced, thanks to technological improvements in aircraft design. Nevertheless, the reduction of noise emissions during a single aircraft operation does not make the issue of the airports’ location less important. This is the case of regional airports in EU, which have recently experimented a large traffic increase due to the development of low-cost traffic. It is now clear that the problem cannot be reduced to its mere technological aspect, but it ought to be dealt with the involvement of the various stakeholders in order to mitigate the emissions and adequately compensate the impacts to local communities. Typically, there are two possible countermeasures to mitigate the effects of aircraft noise: operational measures, based on the application of technological and organizational devices and market-based measures. The application of noise taxes, aiming at compensating the negative externalities generated by airport operations is becoming increasingly widespread in EU. In this paper, a methodology for the application of noise taxes based on the actual noise of aircraft operating into an airport is discussed and implemented in a test case.

Hyaluronic acid enhances cell migration and invasion via the YAP1/TAZ-RHAMM axis in malignant pleural mesothelioma.

Science.gov (United States)

Shigeeda, Wataru; Shibazaki, Masahiko; Yasuhira, Shinji; Masuda, Tomoyuki; Tanita, Tatsuo; Kaneko, Yuka; Sato, Tatsuhiro; Sekido, Yoshitaka; Maesawa, Chihaya

2017-11-07

Most malignant mesotheliomas (MPMs) frequently show activated forms of Yes-associated protein 1 (YAP1) and transcriptional co-activator with PDZ-binding motif (TAZ), which transcriptionally regulates the receptor for hyaluronic acid-mediated motility (RHAMM). As RHAMM is involved in cell migration and invasion in various tumors, we speculated that hyaluronic acid (HA) in pleural fluid might affect the progression of mesothelioma by stimulating cell migration and invasion through RHAMM. The level of RHAMM expression was decreased by YAP1/TAZ knockdown, and conversely increased by forced expression of the active form of YAP1, suggesting that RHAMM was regulated by YAP1/TAZ in MPM cells. Cell migration and invasion were also decreased by YAP1/TAZ or RHAMM knockdown. Notably, HA treatment increased cell motility and invasion, and this was abolished by RHAMM knockdown, suggesting that HA may augment local progression of MPM cells via RHAMM. Furthermore, treatment with fluvastatin, which regulates RHAMM transcription by modulating YAP1/TAZ activity, decreased the motility and invasion of MPM cells. Collectively, these data suggest that HA is an "unfavorable" factor because it promotes malignancy in mesothelioma and that the YAP1/TAZ-RHAMM axis may have potential value as a therapeutic target for inhibition of disease progression in MPM.

The Airport Network Flow Simulator.

Science.gov (United States)

1976-05-01

The impact of investment at an individual airport is felt through-out the National Airport System by reduction of delays at other airports in the the system. A GPSS model was constructed to simulate the propagation of delays through a nine-airport sy...

Inauguration of Cogen Plant ensures self-sustainability for Toronto Airport

International Nuclear Information System (INIS)

Anon.

2006-01-01

Details of a new cogeneration plant for Pearson International Airport were presented. The plant was installed to ensure that the airport will be self-sufficient with its own uninterrupted power supply, and will also provide steam for the airport's heating and cooling. The plant generated its first power onto the grid in August 2005. The 18,000 sq. foot cogeneration facility cost an estimated $140 million to build and is capable of supplying the airport with 117 MW of power. Power for the plant comes from 2 natural gas turbines, with an additional 33 MW generated by exhaust from the gas turbines passing through once-through steam generators producing steam for a third steam-driven generator. The remaining excess heat from the plant is used to heat and cool the airport buildings through a central utilities distribution system. Natural gas fueled cogeneration plants are considered to be clean energy, and it is anticipated that the plant will lessen the environmental impacts of the airport. Currently, the airport's peak electrical demand is approximately 38 MW of electricity, which is expected to peak at 65 to 70 MW in 2015. The surplus electricity produced at the cogeneration plant will be sold back into Ontario's power grid via the Clean Energy Supply contract. It was concluded that in addition to its environmental benefits, the plant will help to enhance electricity supply in the Greater Toronto Area (GTA)

Methodology for Analysis, Modeling and Simulation of Airport Gate-waiting Delays

Science.gov (United States)

Wang, Jianfeng

This dissertation presents methodologies to estimate gate-waiting delays from historical data, to identify gate-waiting-delay functional causes in major U.S. airports, and to evaluate the impact of gate operation disruptions and mitigation strategies on gate-waiting delay. Airport gates are a resource of congestion in the air transportation system. When an arriving flight cannot pull into its gate, the delay it experiences is called gate-waiting delay. Some possible reasons for gate-waiting delay are: the gate is occupied, gate staff or equipment is unavailable, the weather prevents the use of the gate (e.g. lightning), or the airline has a preferred gate assignment. Gate-waiting delays potentially stay with the aircraft throughout the day (unless they are absorbed), adding costs to passengers and the airlines. As the volume of flights increases, ensuring that airport gates do not become a choke point of the system is critical. The first part of the dissertation presents a methodology for estimating gate-waiting delays based on historical, publicly available sources. Analysis of gate-waiting delays at major U.S. airports in the summer of 2007 identifies the following. (i) Gate-waiting delay is not a significant problem on majority of days; however, the worst delay days (e.g. 4% of the days at LGA) are extreme outliers. (ii) The Atlanta International Airport (ATL), the John F. Kennedy International Airport (JFK), the Dallas/Fort Worth International Airport (DFW) and the Philadelphia International Airport (PHL) experience the highest gate-waiting delays among major U.S. airports. (iii) There is a significant gate-waiting-delay difference between airlines due to a disproportional gate allocation. (iv) Gate-waiting delay is sensitive to time of a day and schedule peaks. According to basic principles of queueing theory, gate-waiting delay can be attributed to over-scheduling, higher-than-scheduled arrival rate, longer-than-scheduled gate-occupancy time, and reduced gate

Valuing Manggarai Station – Soekarno-Hatta International Airport Rail Link Using Stated Preference Approach

OpenAIRE

Adi, Wahyu Tamtomo

2015-01-01

This study attempts to identify the characteristics and preference of the SHIA airport travelers, estimate the subjective value of in-vehicle time and waiting time by providing choice experiments regarding the available modes in combination with the Airport Rail Link (ARL) service as hypothetical situation, analyze how the values vary according to the socio-demographics of respondents and forecasting the mode sharing and the elasticity based on several scenarios. Five hundred respondents as p...

Sub-cellular localisation studies may spuriously detect the Yes-associated protein, YAP, in nucleoli leading to potentially invalid conclusions of its function.

Science.gov (United States)

Finch, Megan L; Passman, Adam M; Strauss, Robyn P; Yeoh, George C; Callus, Bernard A

2015-01-01

The Yes-associated protein (YAP) is a potent transcriptional co-activator that functions as a nuclear effector of the Hippo signaling pathway. YAP is oncogenic and its activity is linked to its cellular abundance and nuclear localisation. Activation of the Hippo pathway restricts YAP nuclear entry via its phosphorylation by Lats kinases and consequent cytoplasmic retention bound to 14-3-3 proteins. We examined YAP expression in liver progenitor cells (LPCs) and surprisingly found that transformed LPCs did not show an increase in YAP abundance compared to the non-transformed LPCs from which they were derived. We then sought to ascertain whether nuclear YAP was more abundant in transformed LPCs. We used an antibody that we confirmed was specific for YAP by immunoblotting to determine YAP's sub-cellular localisation by immunofluorescence. This antibody showed diffuse staining for YAP within the cytosol and nuclei, but, noticeably, it showed intense staining of the nucleoli of LPCs. This staining was non-specific, as shRNA treatment of cells abolished YAP expression to undetectable levels by Western blot yet the nucleolar staining remained. Similar spurious YAP nucleolar staining was also seen in mouse embryonic fibroblasts and mouse liver tissue, indicating that this antibody is unsuitable for immunological applications to determine YAP sub-cellular localisation in mouse cells or tissues. Interestingly nucleolar staining was not evident in D645 cells suggesting the antibody may be suitable for use in human cells. Given the large body of published work on YAP in recent years, many of which utilise this antibody, this study raises concerns regarding its use for determining sub-cellular localisation. From a broader perspective, it serves as a timely reminder of the need to perform appropriate controls to ensure the validity of published data.

Arsenic-induced cutaneous hyperplastic lesions are associated with the dysregulation of Yap, a Hippo signaling-related protein

International Nuclear Information System (INIS)

Li, Changzhao; Srivastava, Ritesh K.; Elmets, Craig A.; Afaq, Farrukh; Athar, Mohammad

2013-01-01

Highlights: •Arsenic activates canonical Hippo signaling pathway and up-regulates αCatenin in the skin. •Arsenic activates transcriptional activity of Yap by its nuclear translocation. •Yap is involved in the disruption of tight/adherens junctions in arsenic-exposed animals. -- Abstract: Arsenic exposure in humans causes a number of toxic manifestations in the skin including cutaneous neoplasm. However, the mechanism of these alterations remains elusive. Here, we provide novel observations that arsenic induced Hippo signaling pathway in the murine skin. This pathway plays crucial roles in determining organ size during the embryonic development and if aberrantly activated in adults, contributes to the pathogenesis of epithelial neoplasm. Arsenic treatment enhanced phosphorylation-dependent activation of LATS1 kinase and other Hippo signaling regulatory proteins Sav1 and MOB1. Phospho-LATS kinase is known to catalyze the inactivation of a transcriptional co-activator, Yap. However, in arsenic-treated epidermis, we did not observed its inactivation. Thus, as expected, unphosphorylated-Yap was translocated to the nucleus in arsenic-treated epidermis. Yap by binding to the transcription factors TEADs induces transcription of its target genes. Consistently, an up-regulation of Yap-dependent target genes Cyr61, Gli2, Ankrd1 and Ctgf was observed in the skin of arsenic-treated mice. Phosphorylated Yap is important in regulating tight and adherens junctions through its binding to αCatenin. We found disruption of these junctions in the arsenic-treated mouse skin despite an increase in αCatenin. These data provide evidence that arsenic-induced canonical Hippo signaling pathway and Yap-mediated disruption of tight and adherens junctions are independently regulated. These effects together may contribute to the carcinogenic effects of arsenic in the skin

Shikonin regulates C-MYC and GLUT1 expression through the MST1-YAP1-TEAD1 axis

Energy Technology Data Exchange (ETDEWEB)

Vališ, Karel, E-mail: karel.valis@biomed.cas.cz [Laboratory of Structural Biology and Cell Signaling, Institute of Microbiology, v.v.i., The Czech Academy of Sciences, Prague (Czech Republic); Faculty of Science, Charles University, Prague (Czech Republic); Talacko, Pavel; Grobárová, Valéria [Laboratory of Structural Biology and Cell Signaling, Institute of Microbiology, v.v.i., The Czech Academy of Sciences, Prague (Czech Republic); Faculty of Science, Charles University, Prague (Czech Republic); Černý, Jan [Faculty of Science, Charles University, Prague (Czech Republic); Novák, Petr, E-mail: pnovak@biomed.cas.cz [Laboratory of Structural Biology and Cell Signaling, Institute of Microbiology, v.v.i., The Czech Academy of Sciences, Prague (Czech Republic); Faculty of Science, Charles University, Prague (Czech Republic)

2016-12-10

The general mechanism underlying the tumor suppressor activity of the Hippo signaling pathway remains unclear. In this study, we explore the molecular mechanisms connecting the Hippo signaling pathway with glucose metabolism. We have found that two key regulators of glycolysis, C-MYC and GLUT1, are targets of the Hippo signaling pathway in human leukemia cells. Our results revealed that activation of MST1 by the natural compound shikonin inhibited the expression of GLUT1 and C-MYC. Furthermore, RNAi experiments confirmed the regulation of GLUT1 and C-MYC expression via the MST1-YAP1-TEAD1 axis. Surprisingly, YAP1 was found to positively regulate C-MYC mRNA levels in complex with TEAD1, while it negatively regulates C-MYC levels in cooperation with MST1. Hence, YAP1 serves as a rheostat for C-MYC, which is regulated by MST1. In addition, depletion of MST1 stimulates lactate production, whereas the specific depletion of TEAD1 has an opposite effect. The inhibition of lactate production and cellular proliferation induced by shikonin also depends on the Hippo pathway activity. Finally, a bioinformatic analysis revealed conserved TEAD-binding motifs in the C-MYC and GLUT1 promoters providing another molecular data supporting our observations. In summary, regulation of glucose metabolism could serve as a new tumor suppressor mechanism orchestrated by the Hippo signaling pathway. - Highlights: • Shikonin inhibits C-MYC and GLUT1 expression in MST1 and YAP1 dependent manner. • YAP1-TEAD1 interaction activates C-MYC and GLUT1 expression. • MST1 in cooperation with YAP1 inhibits C-MYC and GLUT1 expression. • MST1-YAP1-TEAD1 axis regulates lactate production by leukemic cells. • MST1 and YAP1 proteins block proliferation of leukemic cells.

Topographic and sedimentary features in the Yap subduction zone and their implications for the Caroline Ridge subduction

Science.gov (United States)

Dong, Dongdong; Zhang, Zhengyi; Bai, Yongliang; Fan, Jianke; Zhang, Guangxu

2018-01-01

The Yap subduction zone in the western Pacific presents some unique features compared to normal intra-oceanic subduction zones such as the subduction of an oceanic plateau. However, due to the relative paucity of geophysical data, the detailed structure remains unknown in this area. In this study, we present the latest high-quality swath bathymetry and multi-channel seismic data acquired synchronously in 2015 across the Yap subduction zone. The topographic and sedimentary features are intensively investigated and a modified evolutionary model of the Yap subduction zone is proposed. The two-stage evolution of the Parece Vela Basin (PVB) produced fabrics that are N-S trending and NW-SE trending. Our seismic data clearly reveal landslide deposits at the upper slope break of the forearc, to the north of the Yap Island, which was identified as the fault notch denoting a lithological boundary in previous work. The swath bathymetry and seismic profile reveal detailed horst and graben structures, including a crescent-shaped fault zone near the contact between the Yap Trench and the Caroline Ridge. A simple geometric model is proposed to explain the structure formation, indicating that the higher topography of the Caroline Ridge resulted in enhanced bending-related extension. A seismic angular unconformity (named R1) is identified in the Sorol Trough, marking the onset of rifting in the trough. Based on the sequence thickness and deposition rate by Deep Sea Drilling Project (DSDP), it is deduced that the Sorol Trough formed at 10 Ma or even earlier. A modified model for the Yap subduction zone evolution is proposed, incorporating three major tectonic events: the proto-Yap Arc rupture in the Oligocene, the collision of the Caroline Ridge and the Yap Trench in the late Oligocene or middle Miocene, and the onset of the Sorol Trough rifting in the late Miocene.

76 FR 31823 - Technical Amendment to List of User Fee Airports: Addition of Dallas Love Field Municipal Airport...

Science.gov (United States)

2011-06-02

...] Technical Amendment to List of User Fee Airports: Addition of Dallas Love Field Municipal Airport, Dallas... fee airport designation for Dallas Love Field Municipal Airport, in Dallas, Texas. User fee airports.... Generally, the type of airport that would seek designation as a user fee airport would be one at which a...

Airport Network Flow Simulator

Science.gov (United States)

1978-10-01

The Airport Network Flow Simulator is a FORTRAN IV simulation of the flow of air traffic in the nation's 600 commercial airports. It calculates for any group of selected airports: (a) the landing and take-off (Type A) delays; and (b) the gate departu...

Airport Pricing Strategies

Science.gov (United States)

Pels, Eric; Verhoef, Erik T.

2003-01-01

Conventional economic wisdom suggests that congestion pricing would be an appropriate response to cope with the growing congestion levels currently experienced at many airports. Several characteristics of aviation markets, however, may make naive congestion prices equal to the value of marginal travel delays a non-optimal response. This paper has developed a model of airport pricing that captures a number of these features. The model in particular reflects that airlines typically have market power and are engaged in oligopolistic competition at different sub-markets; that part of external travel delays that aircraft impose are internal to an operator and hence should not be accounted for in congestion tolls. We presented an analytical treatment for a simple bi-nodal symmetric network, which through the use of 'hyper-networks' would be readily applicable to dynamic problems (in discrete time) such as peak - off-peak differences, and some numerical exercises for the same symmetric network, which was only designed to illustrate the possible comparative static impacts of tolling, in addition to marginal equilibrium conditions as could be derived for the general model specification. Some main conclusions are that second-best optimal tolls are typically lower than what would be suggested by congestion costs alone and may even be negative, and that the toll as derived by Brueckner (2002) may not lead to an increase in total welfare. While Brueckner (2002) has made clear that congestion tolls on airports may be smaller than expected when congestion costs among aircraft are internal for a firm, our analysis adds to this that a further downward adjustment may be in order due to market power. The presence of market power (which causes prices to exceed marginal costs) may cause the pure congestion toll to be suboptimal, because the resulting decrease in demand is too high (the pure congestion tall does not take into account the decrease in consumer surplus). The various

Kamu bürokrasisinde yolsuzluğun yapılaşması

OpenAIRE

CENGİZ, Mahmut

2009-01-01

“Kamu Bürokrasisinde Yolsuzluğun Yapılasması” konulu tezçalısmasında, modernitenin yükselisi ile birlikte imal edilmis risklerin enönemlilerinden kabul edilen yolsuzluğun, Türkiye kamu bürokrasisindeyapılasıp yapılasmadığını ortaya koymak için betimleyici ve açıklayıcı birçalısma yapılması amaçlanmıstır. “Uluslararası Seffaflık Örgütü”nün yapmısolduğu yolsuzluk indeksinde orta sıralarda bulunan Türkiye, yolsuzluğunulusal ve uluslararası düzeyde olumsuz sonuçlarıyla karsılasmaktadır. ...

Literature review of the airport business

NARCIS (Netherlands)

Carmona Benitez, R.B.; Lodewijks, G.

2008-01-01

Airports are very important for economic growth. The demand for airport capacity has been growing very fast and private companies are now also investing in airport infrastructure. Airports must however be regulated because they are natural monopolies with high market power. Airports have variables

An Assessment of Airport Sustainability, Part 1—Waste Management at Copenhagen Airport

Directory of Open Access Journals (Sweden)

Glenn Baxter

2018-03-01

Full Text Available Airports play a vital role in the air transport industry value chain, acting as the interface point between the air and surface transport modes. However, substantial volumes of waste are produced as a by-product of the actors’ operations. Waste management is therefore becoming especially important to airports. Using a qualitative and quantitative case study research approach, this paper has examined the waste management strategies and systems at Copenhagen Airport, Scandinavia’s major air traffic hub, from 1999 to 2016. The two major sources of waste at Copenhagen Airport are the waste generated from aircraft serving the airport and the waste arising from ground activities undertaken in the land and airside precincts. The growth in passengers and aircraft movements has had a concomitant impact on the volume of waste generated. Swept waste and sludge are processed by an external provider. Waste generated in the passenger terminals and the airport operator’s facilities is handled at a central container station, where it is sorted for incineration, recycling or for landfill. The environmental impact of the waste produced at the airport is mitigated through the recycling of waste wherever possible.

Airport Surface Access and Mobile Apps

Directory of Open Access Journals (Sweden)

Luis Martin-Domingo

2015-02-01

Full Text Available Purpose: Airport Surface Access faces two main opposite issues: (1 cars, being the main transport mode, contribute to the increasing level of congestion and pollution of cities; and (2 simultaneously, parking fees are one important source of airports commercial revenue, creating a dilemma for airports when facing the problem. Following the recent trend of air passengers travelling with Smartphone (78% in 2013, the purpose of this paper is to monitor the adoption of mobile Applications (Apps by airports and to analyze if the information and functions provided in those Apps can help to overcome the above two issues. Design/methodology/approach: 31 iPhone App of some of the largest European airports were evaluated in the lab using the evaluation model of Destinations Mobile Applications (Scolari and Fernández-Cavia 2014 adapted for for the Airport Surface Access on Airport Apps Findings and Originality/value: The Apps evaluated provided a very limited functionality to help passengers to plan and book their trips to/from the airports on public transports and gave high priority to parking information and services. Originality/value: Although Airport Surface Access has been a widely researched, the originality of this paper is the analysis of airport mobile Apps as a potential tool for airports to deal with the surface airport access problems.Access, Airports, Mobile Internet, Commercial Revenues

Airport Choice in Sao Paulo Metropolitan Area: An Application of the Conditional Logit Model

Science.gov (United States)

Moreno, Marcelo Baena; Muller, Carlos

2003-01-01

Using the conditional LOGIT model, this paper addresses the airport choice in the Sao Paulo Metropolitan Area. In this region, Guarulhos International Airport (GRU) and Congonhas Airport (CGH) compete for passengers flying to several domestic destinations. The airport choice is believed to be a result of the tradeoff passengers perform considering airport access characteristics, airline level of service characteristics and passenger experience with the analyzed airports. It was found that access time to the airports better explain the airport choice than access distance, whereas direct flight frequencies gives better explanation to the airport choice than the indirect (connections and stops) and total (direct plus indirect) flight frequencies. Out of 15 tested variables, passenger experience with the analyzed airports was the variable that best explained the airport choice in the region. Model specifications considering 1, 2 or 3 variables were tested. The model specification most adjusted to the observed data considered access time, direct flight frequencies in the travel period (morning or afternoon peak) and passenger experience with the analyzed airports. The influence of these variables was therefore analyzed across market segments according to departure airport and flight duration criteria. The choice of GRU (located neighboring Sao Paulo city) is not well explained by the rationality of access time economy and the increase of the supply of direct flight frequencies, while the choice of CGH (located inside Sao Paulo city) is. Access time was found to be more important to passengers flying shorter distances while direct flight frequencies in the travel period were more significant to those flying longer distances. Keywords: Airport choice, Multiple airport region, Conditional LOGIT model, Access time, Flight frequencies, Passenger experience with the analyzed airports, Transportation planning

Involvement of YAP, TAZ and HSP90 in contact guidance and intercellular junction formation in corneal epithelial cells.

Directory of Open Access Journals (Sweden)

Vijay Krishna Raghunathan

Full Text Available The extracellular environment possesses a rich milieu of biophysical and biochemical signaling cues that are simultaneously integrated by cells and influence cellular phenotype. Yes-associated protein (YAP and transcriptional co-activator with PDZ-binding motif (WWTR1; TAZ, two important signaling molecules of the Hippo pathway, have been recently implicated as nuclear relays of cytoskeletal changes mediated by substratum rigidity and topography. These proteins intersect with other important intracellular signaling pathways (e.g. Wnt and TGFβ. In the cornea, epithelial cells adhere to the stroma through a 3-dimensional topography-rich basement membrane, with features in the nano-submicron size-scale that are capable of profoundly modulating a wide range of fundamental cell behaviors. The influences of substratum-topography, YAP/TAZ knockdown, and HSP90 inhibition on cell morphology, YAP/TAZ localization, and the expression of TGFβ2 and CTGF, were investigated. The results demonstrate (a that knockdown of TAZ enhances contact guidance in a YAP dependent manner, (b that CTGF is predominantly regulated by YAP and not TAZ, and (c that TGFβ2 is regulated by both YAP and TAZ in these cells. Additionally, inhibition of HSP90 resulted in nuclear localization and subsequent transcriptional-activation of YAP, formation of cell-cell junctions and co-localization of E-cadherin and β-catenin at adherens junctions. Results presented in this study reflect the complexities underlying the molecular relationships between the cytoskeleton, growth factors, heat shock proteins, and co-activators of transcription that impact mechanotransduction. The data reveal the importance of YAP/TAZ on the cell behaviors, and gene and protein expression.

YAP1 Regulates OCT4 Activity and SOX2 Expression to Facilitate Self-Renewal and Vascular Mimicry of Stem-Like Cells.

Science.gov (United States)

Bora-Singhal, Namrata; Nguyen, Jonathan; Schaal, Courtney; Perumal, Deepak; Singh, Sandeep; Coppola, Domenico; Chellappan, Srikumar

2015-06-01

Non-small cell lung cancer (NSCLC) is highly correlated with smoking and has very low survival rates. Multiple studies have shown that stem-like cells contribute to the genesis and progression of NSCLC. Our results show that the transcriptional coactivator yes-associated protein 1 (YAP1), which is the oncogenic component of the Hippo signaling pathway, is elevated in the stem-like cells from NSCLC and contributes to their self-renewal and ability to form angiogenic tubules. Inhibition of YAP1 by a small molecule or depletion of YAP1 by siRNAs suppressed self-renewal and vascular mimicry of stem-like cells. These effects of YAP1 were mediated through the embryonic stem cell transcription factor, Sox2. YAP1 could transcriptionally induce Sox2 through a physical interaction with Oct4; Sox2 induction occurred independent of TEAD2 transcription factor, which is the predominant mediator of YAP1 functions. The binding of Oct4 to YAP1 could be detected in cell lines as well as tumor tissues; the interaction was elevated in NSCLC samples compared to normal tissue as seen by proximity ligation assays. YAP1 bound to Oct4 through the WW domain, and a peptide corresponding to this region could disrupt the interaction. Delivery of the WW domain peptide to stem-like cells disrupted the interaction and abrogated Sox2 expression, self-renewal, and vascular mimicry. Depleting YAP1 reduced the expression of multiple epithelial-mesenchymal transition genes and prevented the growth and metastasis of tumor xenografts in mice; overexpression of Sox2 in YAP1 null cells rescued these functions. These results demonstrate a novel regulation of stem-like functions by YAP1, through the modulation of Sox2 expression. © 2015 AlphaMed Press.

Radon gamma-ray spectrometry with YAP:Ce scintillator

CERN Document Server

Plastino, W; De Notaristefani, F

2002-01-01

The detection properties of a YAP:Ce scintillator (YAlO sub 3 :Ce crystal) optically coupled to a Hamamatsu H5784 photomultiplier with standard bialkali photocathode have been analyzed. In particular, the application to radon and radon-daughters gamma-ray spectrometry was investigated. The crystal response has been studied under severe extreme conditions to simulate environments of geophysical interest, particularly those found in geothermal and volcanic areas. Tests in water up to a temperature of 100 deg.C and in acids solutions such as HCl (37%), H sub 2 SO sub 4 (48%) and HNO sub 3 (65%) have been performed. The measurements with standard radon sources provided by the National Institute for Metrology of Ionizing Radiations (ENEA) have emphasized the non-hygroscopic properties of the scintillator and a small dependence of the light yield on temperature and HNO sub 3. The data collected in this first step of our research have pointed out that the YAP:Ce scintillator can allow high response stability for rad...

Activation of the oxidative stress regulator PpYap1 through conserved cysteine residues during methanol metabolism in the yeast Pichia pastoris.

Science.gov (United States)

Yano, Taisuke; Yurimoto, Hiroya; Sakai, Yasuyoshi

2009-06-01

The methylotrophic yeast Pichia pastoris can grow on methanol as sole source of carbon and energy. The first reaction in yeast methanol metabolism, catalyzed by an abundant peroxisomal enzyme, alcohol oxidase, generates high levels of H(2)O(2), but the oxidative stress response during methanol metabolism has not been elucidated. In this study, we isolated the Yap1 homolog of P. pastoris (PpYap1) and analyzed the properties of a PpYAP1-disruption strain. The PpYap1 transcription factor is activated after exposure to various reactive agents, and therefore functions as a regulator of the redox system in P. pastoris. We have also identified PpGPX1, the unique glutathione peroxidase-encoding gene in P. pastoris whose expression is induced by PpYap1. PpGpx1, but not the ScTsa1 or SpTpx1 homolog PpTsa1, functions as a H(2)O(2) sensor and activates PpYap1. This study is the first demonstration of a yeast Yap1 family protein activated during conventional metabolism.

Copenhagen Airport Cohort

DEFF Research Database (Denmark)

Møller, Karina Lauenborg; Brauer, Charlotte; Mikkelsen, Sigurd

2017-01-01

PURPOSE: Copenhagen Airport Cohort 1990-2012 presents a unique data source for studies of health effects of occupational exposure to air pollution (ultrafine particles) and manual baggage handling among airport employees. We describe the extent of information in the cohort and in the follow...... covers 69 175 men in unskilled positions. The exposed cohort includes men in unskilled jobs employed at Copenhagen Airport in the period 1990-2012 either as baggage handlers or in other outdoor work. The reference cohort includes men in unskilled jobs working in the greater Copenhagen area. FINDINGS...... TO DATE: The cohort includes environmental Global Positioning System (GPS) measurements in Copenhagen Airport, information on job function/task for each calendar year of employment between 1990 and 2012, exposure to air pollution at residence, average weight of baggage lifted per day and lifestyle...

PRECISE ORTHO IMAGERY AS THE SOURCE FOR AUTHORITATIVE AIRPORT MAPPING

Directory of Open Access Journals (Sweden)

H. Howard

2016-06-01

Full Text Available As the aviation industry moves from paper maps and charts to the digital cockpit and electronic flight bag, producers of these products need current and accurate data to ensure flight safety. FAA (Federal Aviation Administration and ICAO (International Civil Aviation Organization require certified suppliers to follow a defined protocol to produce authoritative map data for the aerodrome. Typical airport maps have been produced to meet 5 m accuracy requirements. The new digital aviation world is moving to 1 m accuracy maps to provide better situational awareness on the aerodrome. The commercial availability of 0.5 m satellite imagery combined with accurate ground control is enabling the production of avionics certified .85 m orthophotos of airports around the globe. CompassData maintains an archive of over 400+ airports as source data to support producers of 1 m certified Aerodrome Mapping Database (AMDB critical to flight safety and automated situational awareness. CompassData is a DO200A certified supplier of authoritative orthoimagery and attendees will learn how to utilize current airport imagery to build digital aviation mapping products.

Precise Ortho Imagery as the Source for Authoritative Airport Mapping

Science.gov (United States)

Howard, H.; Hummel, P.

2016-06-01

As the aviation industry moves from paper maps and charts to the digital cockpit and electronic flight bag, producers of these products need current and accurate data to ensure flight safety. FAA (Federal Aviation Administration) and ICAO (International Civil Aviation Organization) require certified suppliers to follow a defined protocol to produce authoritative map data for the aerodrome. Typical airport maps have been produced to meet 5 m accuracy requirements. The new digital aviation world is moving to 1 m accuracy maps to provide better situational awareness on the aerodrome. The commercial availability of 0.5 m satellite imagery combined with accurate ground control is enabling the production of avionics certified .85 m orthophotos of airports around the globe. CompassData maintains an archive of over 400+ airports as source data to support producers of 1 m certified Aerodrome Mapping Database (AMDB) critical to flight safety and automated situational awareness. CompassData is a DO200A certified supplier of authoritative orthoimagery and attendees will learn how to utilize current airport imagery to build digital aviation mapping products.

Fog Occurrence and Associated Meteorological Factors Over Kempegowda International Airport, India

Science.gov (United States)

Kutty, Saumya G.; Agnihotri, G.; Dimri, A. P.; Gultepe, I.

2018-05-01

The increase in fog frequency over the past few decades is a major cause of concern for the aviation and transportation sectors. Accurate forecasting of the spatio-temporal extent of fog is crucial for minimizing socioeconomic losses. The present study attempts to characterize the fog frequency and associated meteorological factors over Kempegowda International Airport, Bengaluru (KIAB), in Karnataka, India. Maximum fog occurrence is observed during the month of December, followed by January. The time of onset of fog lies usually between 1800 and 0300 UTC. No fog is formed between 0400 and 1700 UTC indicating the role of radiation fog. The predominant wind direction during fog events is east or southeasterly. There is significant positive correlation between the fog frequency and both the northeast monsoon, October-November (0.72), as well as December-January-February (DJF) rainfall (0.80). Soil moisture conditions during the DJF period also play a key role in fog occurrence and its climatology, which is evident from the correlation coefficient of order 0.68. These suggest that further research is needed for understanding the extent of impact on aviation at KIAB.

Large-scale Circulation Control of the Occurrence of Low-level Turbulence at Hong Kong International Airport

Science.gov (United States)

Leung, Marco Y. T.; Zhou, Wen; Shun, Chi-Ming; Chan, Pak-Wai

2018-04-01

This study identifies the atmospheric circulation features that are favorable for the occurrence of low-level turbulence at Hong Kong International Airport [below 1600 feet (around 500 m)]. By using LIDAR data at the airport, turbulence and nonturbulence cases are selected. It is found that the occurrence of turbulence is significantly related to the strength of the southerly wind at 850 hPa over the South China coast. On the other hand, the east-west wind at this height demonstrates a weak relation to the occurrence. This suggests that turbulence is generated by flow passing Lantau Island from the south. The southerly wind also transports moisture from the South China Sea to Hong Kong, reducing local stability. This is favorable for the development of strong turbulence. It is also noted that the strong southerly wind during the occurrence of low-level turbulence is contributed by an anomalous zonal gradient of geopotential in the lower troposphere over the South China Sea. This gradient is caused by the combination of variations at different timescales. These are the passage of synoptic extratropical cyclones and anticyclones and the intraseasonal variation in the western North Pacific subtropical high. The seasonal variation in geopotential east of the Tibetan Plateau leads to a seasonal change in meridional wind, by which the frequency of low-level turbulence is maximized in spring and minimized in autumn.

Taxi Time Prediction at Charlotte Airport Using Fast-Time Simulation and Machine Learning Techniques

Science.gov (United States)

Lee, Hanbong

2016-01-01

Accurate taxi time prediction is required for enabling efficient runway scheduling that can increase runway throughput and reduce taxi times and fuel consumptions on the airport surface. Currently NASA and American Airlines are jointly developing a decision-support tool called Spot and Runway Departure Advisor (SARDA) that assists airport ramp controllers to make gate pushback decisions and improve the overall efficiency of airport surface traffic. In this presentation, we propose to use Linear Optimized Sequencing (LINOS), a discrete-event fast-time simulation tool, to predict taxi times and provide the estimates to the runway scheduler in real-time airport operations. To assess its prediction accuracy, we also introduce a data-driven analytical method using machine learning techniques. These two taxi time prediction methods are evaluated with actual taxi time data obtained from the SARDA human-in-the-loop (HITL) simulation for Charlotte Douglas International Airport (CLT) using various performance measurement metrics. Based on the taxi time prediction results, we also discuss how the prediction accuracy can be affected by the operational complexity at this airport and how we can improve the fast time simulation model before implementing it with an airport scheduling algorithm in a real-time environment.

Kahramanmaraş İlindeki Tekstil Firmalarının Dış Ticaret Yapısı

OpenAIRE

AKBAY, Cuma; DOĞAROĞLU, Sibel

2016-01-01

Bu araştırmada Kahramanmaraş ilinde faaliyet gösteren tekstil firmalarının dış ticaret yapısı incelenerek mevcut yapının ortaya konulması yanında; işletmelerin dış ticaret yapısının büyüklüklerini doğrudan nasıl etkilediğinin, işletmelerin dış ticaret yapısı ve Kahramanmaraş ilinde tekstil firmalarında ithalat-ihracat işlemlerinin profesyonel durumunun, dış ticaret biriminin öneminin, dış ticarette ihtiyaç duyulan bilgilerin, işletmelerin geçmiş yıllarda dış ticarette karşılaşmış olduğu sorun...

Self-mode-locking operation of a diode-end-pumped Tm:YAP laser with watt-level output power

Science.gov (United States)

Zhang, Su; Zhang, Xinlu; Huang, Jinjer; Wang, Tianhan; Dai, Junfeng; Dong, Guangzong

2018-03-01

We report on a high power continuous wave (CW) self-mode-locked Tm:YAP laser pumped by a 792 nm laser diode. Without any additional mode-locking elements in the cavity, stable and self-starting mode-locking operation has been realized. The threshold pump power of the CW self-mode-locked Tm:YAP laser is only 5.4 W. The maximum average output power is as high as 1.65 W at the pump power of 12 W, with the repetition frequency of 468 MHz and the center wavelength of 1943 nm. To the best of our knowledge, this is the first CW self-mode-locked Tm:YAP laser. The experiment results show that the Tm:YAP crystal is a promising gain medium for realizing the high power self-mode-locking operation at 2 µm.

U.S. Airport Greenhouse Gas Emissions Inventories: State of the Practice and Recommendations for Airports.

Science.gov (United States)

2016-03-01

This document presents highlights from five research reports on airport greenhouse gas (GHG) emissions inventories. It presents the most salient findings for policy makers and U.S. airports seeking to better understand and inventory airport GHG emiss...

YAP(Ce) crystal characterization with proton beam up to 60 MeV

Energy Technology Data Exchange (ETDEWEB)

Randazzo, N. [Istituto Nazionale di Fisica Nucleare, Sezione di Catania (I), Via S. Sofia, 64-I-95123 Catania (Italy)], E-mail: nunzio.randazzo@ct.infn.it; Sipala, V.; Aiello, S. [Istituto Nazionale di Fisica Nucleare, Sezione di Catania (I), Via S. Sofia, 64-I-95123 Catania (Italy); Lo Presti, D. [Istituto Nazionale di Fisica Nucleare, Sezione di Catania (I), Via S. Sofia, 64-I-95123 Catania (Italy); Dipartimento di Fisica e Astronomia, Universita di Catania, Catania (Italy); Cirrone, G.A.P.; Cuttone, G.; Di Rosa, F. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali del Sud (Italy)

2008-02-21

A YAP(Ce) crystal was characterized with a proton beam up to 60 MeV. Tests were performed to investigate the possibility of using this detector as a proton calorimeter. The size of the crystal was chosen so that the proton energy is totally lost inside the medium. The authors propose to use the YAP(Ce) crystal in medical applications for proton therapy. In particular, in proton computed tomography (pCT) project it is necessary as a calorimeter in order to measure the proton residual energy after the phantom. Energy resolution, linearity, and light yield were measured in the Laboratori Nazionali del Sud with the CATANA proton beam [ (http://www.lns.infn.it/CATANA/CATANA)] and the results are shown in this paper. The crystal shows a good resolution (3% at 60 MeV proton beam) and it shows good linearity for different proton beam energies (1% at 30-60 MeV energy range). The crystal performances confirm that the YAP(Ce) crystal represents a good solution for these kinds of application.

YAP(Ce) crystal characterization with proton beam up to 60 MeV

International Nuclear Information System (INIS)

Randazzo, N.; Sipala, V.; Aiello, S.; Lo Presti, D.; Cirrone, G.A.P.; Cuttone, G.; Di Rosa, F.

2008-01-01

A YAP(Ce) crystal was characterized with a proton beam up to 60 MeV. Tests were performed to investigate the possibility of using this detector as a proton calorimeter. The size of the crystal was chosen so that the proton energy is totally lost inside the medium. The authors propose to use the YAP(Ce) crystal in medical applications for proton therapy. In particular, in proton computed tomography (pCT) project it is necessary as a calorimeter in order to measure the proton residual energy after the phantom. Energy resolution, linearity, and light yield were measured in the Laboratori Nazionali del Sud with the CATANA proton beam [ (http://www.lns.infn.it/CATANA/CATANA)] and the results are shown in this paper. The crystal shows a good resolution (3% at 60 MeV proton beam) and it shows good linearity for different proton beam energies (1% at 30-60 MeV energy range). The crystal performances confirm that the YAP(Ce) crystal represents a good solution for these kinds of application

YAP(Ce) crystal characterization with proton beam up to 60 MeV

Science.gov (United States)

Randazzo, N.; Sipala, V.; Aiello, S.; Lo Presti, D.; Cirrone, G. A. P.; Cuttone, G.; Di Rosa, F.

2008-02-01

A YAP(Ce) crystal was characterized with a proton beam up to 60 MeV. Tests were performed to investigate the possibility of using this detector as a proton calorimeter. The size of the crystal was chosen so that the proton energy is totally lost inside the medium. The authors propose to use the YAP(Ce) crystal in medical applications for proton therapy. In particular, in proton computed tomography (pCT) project it is necessary as a calorimeter in order to measure the proton residual energy after the phantom. Energy resolution, linearity, and light yield were measured in the Laboratori Nazionali del Sud with the CATANA proton beam [ http://www.lns.infn.it/CATANA/CATANA] and the results are shown in this paper. The crystal shows a good resolution (3% at 60 MeV proton beam) and it shows good linearity for different proton beam energies (1% at 30-60 MeV energy range). The crystal performances confirm that the YAP(Ce) crystal represents a good solution for these kinds of application.

76 FR 17986 - Public Notice for Waiver of Aeronautical Land-Use Assurance; Capital Region International Airport...

Science.gov (United States)

2011-03-31

... activities during airport development are not usable to the airport due to shape and size. There are no... to Consumers Energy (to give 162.67 feet frontage on proposed Dewitt road). PART OF THE NORTH \\1/2... SOUTHEAST CORNER OF SAID SECTION: (I)NO1-2323-30W. ALONG THE EAST LINE OF SAID SECTION, 1324.86 FEET AND (2...

THE BUILDING PROJECT FOR CAR TRESTLE AS A PART OF THE TERMINAL COMPLEX AT INTERNATIONAL AIRPORT “BORISPOL”

Directory of Open Access Journals (Sweden)

Yu. S. Zorkin

2010-04-01

Full Text Available In the article it is presented the basic content of construction project for car trestle as a part of the terminal complex at international airport «Borispol» worked out by the State Enterprise «The research and design institute of transport construction «Kievgiprotrans» in accordance with the specifications approved by the Representative Office of «Догуш Иншаат Ве Тиджарет Аноним Ширкети» and with the project estimate documentation.

Airports Geographic Information System -

Data.gov (United States)

Department of Transportation — The Airports Geographic Information System maintains the airport and aeronautical data required to meet the demands of the Next Generation National Airspace System....

Passenger Flow Forecasting Research for Airport Terminal Based on SARIMA Time Series Model

Science.gov (United States)

Li, Ziyu; Bi, Jun; Li, Zhiyin

2017-12-01

Based on the data of practical operating of Kunming Changshui International Airport during2016, this paper proposes Seasonal Autoregressive Integrated Moving Average (SARIMA) model to predict the passenger flow. This article not only considers the non-stationary and autocorrelation of the sequence, but also considers the daily periodicity of the sequence. The prediction results can accurately describe the change trend of airport passenger flow and provide scientific decision support for the optimal allocation of airport resources and optimization of departure process. The result shows that this model is applicable to the short-term prediction of airport terminal departure passenger traffic and the average error ranges from 1% to 3%. The difference between the predicted and the true values of passenger traffic flow is quite small, which indicates that the model has fairly good passenger traffic flow prediction ability.

Structure of a 14-3-3σ–YAP phosphopeptide complex at 1.15 Å resolution

International Nuclear Information System (INIS)

Schumacher, Benjamin; Skwarczynska, Malgorzata; Rose, Rolf; Ottmann, Christian

2010-01-01

The first structure of a 14-3-3 protein–phosphopeptide complex is reported at 1.15 Å resolution. The YAP 14-3-3-binding motif is revealed for the first time using crystallographic tools. The 14-3-3 proteins are a class of eukaryotic acidic adapter proteins, with seven isoforms in humans. 14-3-3 proteins mediate their biological function by binding to target proteins and influencing their activity. They are involved in pivotal pathways in the cell such as signal transduction, gene expression, enzyme activation, cell division and apoptosis. The Yes-associated protein (YAP) is a WW-domain protein that exists in two transcript variants of 48 and 54 kDa in humans. By transducing signals from the cytoplasm to the nucleus, YAP is important for transcriptional regulation. In both variants, interaction with 14-3-3 proteins after phosphorylation of Ser127 is important for nucleocytoplasmic trafficking, via which the localization of YAP is controlled. In this study, 14-3-3σ has been cloned, purified and crystallized in complex with a phosphopeptide from the YAP 14-3-3-binding domain, which led to a crystal that diffracted to 1.15 Å resolution. The crystals belonged to space group C222 1 , with unit-cell parameters a = 82.3, b = 112.1, c = 62.9 Å

75 FR 41922 - Notice of Intent To Rule on Request To Release Airport Property at Fort Smith Regional Airport...

Science.gov (United States)

2010-07-19

... To Release Airport Property at Fort Smith Regional Airport, Fort Smith, AR AGENCY: Federal Aviation... rule and invites public comment on the release of land at Fort Smith Regional Airport under the.... John Parker, Airport Director, Fort Smith Regional Airport, at the following address: Fort Smith...

Airport Performance and Construction Enlargement Activities

Science.gov (United States)

Hanun, Y.; Setiawan, M. I.; Kurniasih, N.; Hasyim, C.; Ahmar, A. S.

2018-01-01

The evaluation of transportation infrastructure project should consider the contribution towards infrastructure growth. This research aims to analyze the effect of Construction enlargement activities towards airport performance. This research is correlation study. The population includes 148 airports in Indonesia. By using total sampling, there were 148 sample airports. The result shows that the construction enlargement activities variable has relatively strong relationship to Airport Performance variable, while the adjusted R Square score shows the increasing construction enlargement activities that affected by the other factors aside from airport performance.

14 CFR 151.3 - National Airport Plan.

Science.gov (United States)

2010-01-01

... provide a system of public airports adequate to anticipate and meet the needs of civil aeronautics. (b) If... in the National Airport Plan. Only work on an airport included in the current Plan is eligible for... not required to proceed with planning or development of an airport included in the National Airport...

Normal hematopoietic stem cell function in mice with enforced expression of the Hippo signaling effector YAP1.

Directory of Open Access Journals (Sweden)

Lina Jansson

Full Text Available The Hippo pathway has recently been implicated in the regulation of organ size and stem cells in multiple tissues. The transcriptional cofactor yes-associated protein 1 (Yap1 is the most downstream effector of Hippo signaling and is functionally repressed by the upstream components of the pathway. Overexpression of YAP1 stimulates proliferation of stem and progenitor cells in many tissues, consistent with inhibition of Hippo signaling. To study the role of Hippo signaling in hematopoietic stem cells (HSCs, we created a transgenic model with inducible YAP1 expression exclusively within the hematopoietic system. Following 3 months induction, examination of blood and bone marrow in the induced mice revealed no changes in the distribution of the hematopoietic lineages compared to control mice. Moreover, the progenitor cell compartment was unaltered as determined by colony forming assays and immunophenotyping. To address whether YAP1 affects the quantity and function of HSCs we performed competitive transplantation experiments. We show that ectopic YAP1 expression does not influence HSC function neither during steady state nor in situations of hematopoietic stress. This is in sharp contrast to effects seen on stem- and progenitor cells in other organs and suggests highly tissue specific functions of the Hippo pathway in regulation of stem cells.

76 FR 76810 - Public Notice for Waiver of Aeronautical Land-Use Assurance; Austin Straubel International...

Science.gov (United States)

2011-12-08

... Aeronautical Land-Use Assurance; Austin Straubel International Airport, Green Bay, WI AGENCY: Federal Aviation... the Austin Straubel International Airport, Green Bay, WI. Brown County, as sponsor of the airport, is... located on, or adjacent to, Austin Straubel International Airport. One parcel contains a roadway section...

Airports and Airfields, Airports within Johnson County as well as runway depicted with attribute information of both airport and runway., Published in Not Provided, Johnson County Government.

Data.gov (United States)

NSGIC Local Govt | GIS Inventory — Airports and Airfields dataset current as of unknown. Airports within Johnson County as well as runway depicted with attribute information of both airport and runway..

A global airport-based risk model for the spread of dengue infection via the air transport network.

Directory of Open Access Journals (Sweden)

Lauren Gardner

Full Text Available The number of travel-acquired dengue infections has seen a consistent global rise over the past decade. An increased volume of international passenger air traffic originating from regions with endemic dengue has contributed to a rise in the number of dengue cases in both areas of endemicity and elsewhere. This paper reports results from a network-based risk assessment model which uses international passenger travel volumes, travel routes, travel distances, regional populations, and predictive species distribution models (for the two vector species, Aedes aegypti and Aedes albopictus to quantify the relative risk posed by each airport in importing passengers with travel-acquired dengue infections. Two risk attributes are evaluated: (i the risk posed by through traffic at each stopover airport and (ii the risk posed by incoming travelers to each destination airport. The model results prioritize optimal locations (i.e., airports for targeted dengue surveillance. The model is easily extendible to other vector-borne diseases.

Book Review: Airport Competition: The European Experience

Directory of Open Access Journals (Sweden)

Garry Gumelar Pratama

2017-08-01

Full Text Available The competitive business environment in aviation industry has changed since European Integration. Not only airlines become more competitive after s­uch integration, but also other main infrastructure of aviation, airports. At the first stage of regional development, competition in airport industry seems to be impossible since all countries in a region still have clear jurisdictional boundaries. The other side of the coin is that airport competition becomes an important issue in a more integrated region, such as European Union (EU. This occurs because an airport owner from another country can buy other airports outside its state jurisdiction, under the same region. Articles in this book prove the claim of the existence of airport competition. Under the introductory part, the editors outlined three cases from EU: UK Civil Aviation Authority action to Heathrow Airport in 2008, Blocked Takeover of Bratislava Airport 2006 and European Commission Prohibition on Subsidies to Ryanair by Brussels South Charleroi Airport 2004. All of the cases are inevitable proofs that airport competition undoubtedly exists in Europe.

Economic utilization of general aviation airport runways

Science.gov (United States)

Piper, R. R.

1971-01-01

The urban general aviation airport economics is studied in detail. The demand for airport services is discussed, and the different types of users are identified. The direct cost characteristics of the airport are summarized; costs to the airport owner are largely fixed, and, except at certain large airports, weight is not a significant factor in airport costs. The efficient use of an existing airport facility is explored, with the focus on the social cost of runway congestion as traffic density at the airport build up and queues form. The tradeoff between aircraft operating costs and airport costs is analyzed in terms of runway length. The transition from theory to practice is treated, and the policy of charging prices only on aircraft storage and fuel is felt likely to continue. Implications of the study from the standpoint of public policy include pricing that spreads traffic peaks to improve runway utilization, and pricing that discriminates against aircraft requiring long runways and causes owners to adopt V/STOL equipment.

The Lisbon new international airport: The story of a decision-making process and the role of Strategic Environmental Assessment

International Nuclear Information System (INIS)

Partidario, Maria R.; Coutinho, Miguel

2011-01-01

This is the brief story of a decision process and the role of Strategic Environmental Assessment in government political decision-making. Following a prolonged, and agitated, decision process, initiated in the 1960s, the Government of Portugal in 2005 took the final decision to build the new international airport of Lisbon at the controversial location of Ota, 40 km north of Lisbon. The detailed project design and EIA were started. However this decision would change in 2007 due to the challenge raised by a private sponsored study that identified an alternative location for the airport at Campo de Tiro de Alcochete (CTA). This new site, which had never been considered as an option before, appeared to avoid many of the problems that caused public controversy at the Ota site. The Government, pressured by this challenge, promoted a strategic comparative assessment between the two sites. The result of this study was the choice of CTA as the preferred location. This paper discusses this radical change in the decision from a socio-political perspective. It will highlight the relevance of Strategic Environmental Assessment (SEA), and the strategic and constructive approach it enables in mega-project decision-making.

YAP scintillators for resonant detection of epithermal neutrons at pulsed neutron sources

International Nuclear Information System (INIS)

Tardocchi, M.; Gorini, G.; Pietropaolo, A.; Andreani, C.; Senesi, R.; Rhodes, N.; Schooneveld, E. M.

2004-01-01

Recent studies indicate the resonance detector (RD) technique as an interesting approach for neutron spectroscopy in the electron volt energy region. This work summarizes the results of a series of experiments where RD consisting of YAlO 3 (YAP) scintillators were used to detect scattered neutrons with energy in the range 1-200 eV. The response of YAP scintillators to radiative capture γ emission from a 238 U analyzer foil was characterized in a series of experiments performed on the VESUVIO spectrometer at the ISIS pulsed neutron source. In these experiments a biparametric data acquisition allowed the simultaneous measurements of both neutron time-of-flight and γ pulse height (energy) spectra. The analysis of the γ pulse height and neutron time of flight spectra permitted to identify and distinguish the signal and background components. These measurements showed that a significant improvement in the signal-to-background ratio can be achieved by setting a lower level discrimination on the pulse height at about 600 keV equivalent photon energy. Present results strongly indicate YAP scintillators as the ideal candidate for neutron scattering studies with epithermal neutrons at both very low (<5 deg.) and intermediate scattering angles

77 FR 44515 - Airport Improvement Program (AIP): Policy Regarding Access to Airports From Residential Property

Science.gov (United States)

2012-07-30

... commercial service airport sponsor's inability to comply with the law and/or the standards of compliance as a...) proposes that the FAA may consider a commercial service airport's inability to comply with the law and/or... the access plan represents an Agency determination that the commercial service airport has met the law...

Mediator, SWI/SNF and SAGA complexes regulate Yap8-dependent transcriptional activation of ACR2 in response to arsenate.

Science.gov (United States)

Menezes, Regina Andrade; Pimentel, Catarina; Silva, Ana Rita Courelas; Amaral, Catarina; Merhej, Jawad; Devaux, Frédéric; Rodrigues-Pousada, Claudina

2017-04-01

Response to arsenic stress in Saccharomyces cerevisiae is orchestrated by the regulatory protein Yap8, which mediates transcriptional activation of ACR2 and ACR3. This study contributes to the state of art knowledge of the molecular mechanisms underlying yeast stress response to arsenate as it provides the genetic and biochemical evidences that Yap8, through cysteine residues 132, 137, and 274, is the sensor of presence of arsenate in the cytosol. Moreover, it is here reported for the first time the essential role of the Mediator complex in the transcriptional activation of ACR2 by Yap8. Based on our data, we propose an order-of-function map to recapitulate the sequence of events taking place in cells injured with arsenate. Modification of the sulfhydryl state of these cysteines converts Yap8 in its activated form, triggering the recruitment of the Mediator complex to the ACR2/ACR3 promoter, through the interaction with the tail subunit Med2. The Mediator complex then transfers the regulatory signals conveyed by Yap8 to the core transcriptional machinery, which culminates with TBP occupancy, ACR2 upregulation and cell adaptation to arsenate stress. Additional co-factors are required for the transcriptional activation of ACR2 by Yap8, particularly the nucleosome remodeling activity of SWI/SNF and SAGA complexes. Copyright © 2017. Published by Elsevier B.V.

THE EFFECT OF PERSON-ORGANIZATION FIT ON JOB STRESSANDCONFLICT: AN APPLICATION ON EMPLOYEES OF BUSINESSESINDALAMAN INTERNATIONAL AIRPORT

Directory of Open Access Journals (Sweden)

Mehmet ULUTAŞ

2011-01-01

Full Text Available Person-organization fit, which is generally described as a degree of compatibilityor similarity between the person’s values and theorganization’s values, is one ofthe base factors required for an organization’s success. Organizations shouldaccomplish person-organization fit in their organizations by using employeeselection and hiring process which is congruence-based in cultural values or byapplying socialization tactics. We proposed findinga correlation in this studybetween person-organization fit and job stress andconflict. In this context, wehave reached some findings about person-organization fit and its outcomes byconducting a survey on employees of Dalaman International Airport. The findingsshowed us there is a statistically negative correlation between person-organization fit and job stress and conflict.

The Establishment of LTO Emission Inventory of Civil Aviation Airports Based on Big Data

Science.gov (United States)

Lu, Chengwei; Liu, Hefan; Song, Danlin; Yang, Xinyue; Tan, Qinwen; Hu, Xiang; Kang, Xue

2018-03-01

An estimation model on LTO emissions of civil aviation airports was developed in this paper, LTO big data was acquired by analysing the internet with Python, while the LTO emissions was dynamically calculated based on daily LTO data, an uncertainty analysis was conducted with Monte Carlo method. Through the model, the emission of LTO in Shuangliu International Airport was calculated, and the characteristics and temporal distribution of LTO in 2015 was analysed. Results indicates that compared with the traditional methods, the model established can calculate the LTO emissions from different types of airplanes more accurately. Based on the hourly LTO information of 302 valid days, it was obtained that the total number of LTO cycles in Chengdu Shuangliu International Airport was 274,645 and the annual amount of emission of SO2, NOx, VOCs, CO, PM10 and PM2.5 was estimated, and the uncertainty of the model was around 7% to 10% varies on pollutants.

Traffic Management System on Airport Manoeuvring Areas

Directory of Open Access Journals (Sweden)

Miroslav Borković

2006-11-01

Full Text Available In the last twenty years the number of flights at the busiestairports in the world has doubled, which, in the meantime hasled to a situation in which runways and taxi ways (manoeuvringareas cannot follow such substantial increase. As the result,many airports could not use their capacities in the full range interms of handling passengers and cargo. As a consequence,there were delays and traffic congestion, fuel was unnecessarilywasted, all of which caused negative impact on the environment.Traffic capacity increase on the ground cannot be consideredwithout the development and implementation of thesystem infrastructure that would optimize traffic flows and itsdistribution on the airport itself In these terms, and for positivesolution of these problems, a new system for surveillance andcontrol of aircraft on the airport manoeuvring areas is necessary,one which could be implemented fairly quickly, would becomplementary with the existing international standards andwould be upgraded to the existing and available technology andinfrastructure. With the implementation of the Advanced SurfaceMonitoring and Control System (A-SMGCS the aircrafttaxiing time could be significantly shortened and could be determinedmore accurately, which would have positive impacton the flight schedule. The unnecessary aircraft braking actionscould be also avoided, and this would reduce the fuel consumption,as well as noise and environmental pollution.

Observations of wintering Snowy Owls (Nyctea scandiaca) at Logan Airport, East Boston, Massachusetts from 1981-1997

Science.gov (United States)

Norman Smith

1997-01-01

Snowy Owls (Nyctea scandiaca) wintering at Logan International Airport were studied over the 15-year period of 1981-1997. Two-hundred twenty-seven Snowy Owls were banded and color-marked to examine the length of time individual birds stayed at this location and to track the movements elsewhere. Fifty-six owls were re-observed outside of the airport...

Temperature influence on spectroscopic properties and 2.7-μm lasing of Er:YAP crystal

Science.gov (United States)

Švejkar, Richard; Šulc, Jan; Němec, Michal; Jelínková, Helena; Nejezchleb, Karel; Čech, Miroslav

2018-02-01

The spectroscopic and laser properties of Er:YAP crystal, that is appropriate for generation at 2.7 μm, in temperature range 78 - 400 K are presented. The sample of Er:YAP (1 at. % of Er3+) had face-polished plan-parallel faces without anti-reflection coatings (thickness 4.47 mm). During experiments the Er:YAP was attached to temperature controlled copper holder and it was placed in vacuum chamber. The transmission and emission spectra together with the fluorescence decay time were measured depending on temperature. The Er:YAP crystal was longitudinally pumped by radiation from laser diode that works in pulse regime (repetition rate 66.6 Hz, pulse duration 1.5 ms, pump wavelength 972.5 nm) or in CW regime. Laser resonator was hemispherical, 145 mm in length with flat pumping mirror (HR @ 2.7 μm) and spherical output coupler (r = 150 mm, R = 95 % @ 2.5 - 2.8 μm). The fluorescence decay time of manifold 4I11/2 (upper laser level) became shorter and intensity of up-conversion radiation was increasing with decreasing temperature. In pulsed regime, the highest slope efficiency with respect to absorbed mean power was 1.27 % at 78 K. The maximum output of mean power was 3.5 mW at 78 K, i.e. 8.7 times higher than measured this value at 300 K. The maximal output power 27 mW with slope efficiency up to 3.5 % was achieved in CW. The radiation generated by Er:YAP laser (2.73 μm) is close to absorption peak of water (3 μm) thus this wavelength can be use in medicine and spectroscopy.

Framework for determining airport daily departure and arrival delay thresholds: statistical modelling approach.

Science.gov (United States)

Wesonga, Ronald; Nabugoomu, Fabian

2016-01-01

The study derives a framework for assessing airport efficiency through evaluating optimal arrival and departure delay thresholds. Assumptions of airport efficiency measurements, though based upon minimum numeric values such as 15 min of turnaround time, cannot be extrapolated to determine proportions of delay-days of an airport. This study explored the concept of delay threshold to determine the proportion of delay-days as an expansion of the theory of delay and our previous work. Data-driven approach using statistical modelling was employed to a limited set of determinants of daily delay at an airport. For the purpose of testing the efficacy of the threshold levels, operational data for Entebbe International Airport were used as a case study. Findings show differences in the proportions of delay at departure (μ = 0.499; 95 % CI = 0.023) and arrival (μ = 0.363; 95 % CI = 0.022). Multivariate logistic model confirmed an optimal daily departure and arrival delay threshold of 60 % for the airport given the four probable thresholds {50, 60, 70, 80}. The decision for the threshold value was based on the number of significant determinants, the goodness of fit statistics based on the Wald test and the area under the receiver operating curves. These findings propose a modelling framework to generate relevant information for the Air Traffic Management relevant in planning and measurement of airport operational efficiency.

Airport Managers' Perspectives on Security and Safety Management Systems in Aviation Operations: A Multiple Case Study

Science.gov (United States)

Brown, Willie L., Jr.

Global terrorism continues to persist despite the great efforts of various countries to protect and safely secure their citizens. As airports form the entry and exit ports of a country, they are one of the most vulnerable locations to terror attacks. Managers of international airports constantly face similar challenges in developing and implementing airport security protocols. Consequently, the technological advances of today have brought both positive and negative impacts on security and terrorism of airports, which are mostly managed by the airport managers. The roles of the managers have greatly increased over the years due to technological advances. The developments in technology have had different roles in security, both in countering terrorism and, at the same time, increasing the communication methods of the terrorists. The purpose of this qualitative multiple case study was to investigate the perspectives of airport managers with regard to societal security and social interactions in the socio-technical systems of the National Terrorism Advisory System (NTAS). Through the data gained regarding managers' perception and experiences, the researcher hoped to enable the development of security measures and policies that are appropriate for airports as socio-technical systems. The researcher conducted interviews with airport managers to gather relevant data to fulfill the rationale of the study. Ten to twelve airport managers based in three commercial aviation airports in Maryland, United States participated in the study. The researcher used a qualitative thematic analysis procedure to analyze the data responses of participants in the interview sessions.

Observed Changes in Atmospheric Boundary Layer Properties at Memphis International Airport During August 1995

Science.gov (United States)

Zak, J. Allen; Rodgers, William G., Jr.

1997-01-01

As part of the NASA Terminal Area Productivity Program, Langley Research Center embarked on a series of field measurements of wake vortex characteristics and associated atmospheric boundary layer properties. One measurement period was at the Memphis International Airport in August 1995. Atmospheric temperature, humidity, winds, turbulence, radiation, and soil properties were measured from a variety of sensor systems and platforms including sodars, profilers, aircraft and towers. This research focused on: (1) changes that occurred in tower data during sunrise and sunset transitions, (2) vertical variation of temperature and cross-head winds at selected times utilizing combinations of sensors, and (3) changes measured by an OV-10 aircraft during approaches and level flights. Significant but not unusual changes are documented and discussed in terms of expected boundary layer behavior. Questions on measurement and prediction of these changes from existing and near-term capabilities are discussed in the context of a future Aircraft Vortex Spacing System.

Missouri airport investment study

Science.gov (United States)

The studys purpose is to provide MoDOT with insight to the potential ROI for airport : investments in terms of economic development. To do so, this study addresses two central : objectives: first, an approach to evaluate airport investments; and s...

Gamma induced atom displacements in LYSO and LuYAP crystals as used in medical imaging applications

Energy Technology Data Exchange (ETDEWEB)

Piñera, Ibrahin, E-mail: ipinera@ceaden.edu.cu [Centro de Aplicaciones Tecnológicas y Desarrollo Nuclear, CEADEN, 30 St. 502, Playa 11300, Havana (Cuba); Cruz, Carlos M.; Abreu, Yamiel; Leyva, Antonio [Centro de Aplicaciones Tecnológicas y Desarrollo Nuclear, CEADEN, 30 St. 502, Playa 11300, Havana (Cuba); Van Espen, Piet [University of Antwerp, CGB, Groenenborgerlaan 171, 2020 Antwerpen (Belgium); Díaz, Angelina; Cabal, Ana E. [Centro de Aplicaciones Tecnológicas y Desarrollo Nuclear, CEADEN, 30 St. 502, Playa 11300, Havana (Cuba); Van Remortel, Nick [University of Antwerp, CGB, Groenenborgerlaan 171, 2020 Antwerpen (Belgium)

2015-08-01

The radiation damage, in terms of atom displacements, induced by gamma irradiation in LYSO and LuYAP crystals is presented. {sup 44}Sc, {sup 22}Na and {sup 48}V are used as gamma sources for this study. The energy of gammas from the electron–positron annihilation processes (511 keV) is also included in the study. The atom displacements distributions inside each material are calculated following the Monte Carlo assisted Classical Method introduced by the authors. This procedure also allows to study the atom displacements in-depth distributions inside each crystal. The atom displacements damage in LYSO crystals is found to be higher than in LuYAP crystals, mainly provoked by the displacements of silicon and oxygen atoms. But the difference between atom displacements produced in LYSO and LuYAP decreases when more energetic sources are used. On the other hand, the correlation between the atom displacements and energy deposition in-depth distributions is excellent. The atom displacements to energy deposition ratio is found to increases with more energetic photon sources. LYSO crystals are then more liable to the atom displacements damage than LuYAP crystals.

76 FR 30422 - Notice of Intent To Rule on Request To Release Airport Property at the Helena Regional Airport...

Science.gov (United States)

2011-05-25

... To Release Airport Property at the Helena Regional Airport, Helena, Montana AGENCY: Federal Aviation Administration (FAA), Department of Transportation (DOT). ACTION: Notice of Request to Release Airport Property... Airport (HLN) under the provisions of Section 125 of the Wendell H. Ford Aviation Investment Reform Act...

76 FR 18622 - Notice of Intent To Rule on Request To Release Airport Property at the Helena Regional Airport...

Science.gov (United States)

2011-04-04

... To Release Airport Property at the Helena Regional Airport, Helena, MT AGENCY: Federal Aviation Administration (FAA), Department of Transportation (DOT). ACTION: Notice of request to release airport property... Airport (HLN) under the provisions of Section 125 of the Wendell H. Ford Aviation Investment Reform Act...

Access to automatic defibrillation at airports on an example of Warsaw Chopin Airport

Directory of Open Access Journals (Sweden)

Witold Pawłowski

2017-08-01

Full Text Available Sudden cardiac arrest and cessation of blood circulation is the most common cause of death of people around the world. Immediate notification of emergency services and cardiopulmonary resuscitation combined with an automatic external defibrillator (AED increases the chances of survivors. Warsaw Chopin Airport is the only public place in Poland and the third one in Europe where a complex and integrated life saving system has been implemented in the ICC. The paper presents an analysis of the access to automatic defibrillation at airports at the Warsaw Chopin Airport

Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry.

Science.gov (United States)

Feng, Xiaodong; Degese, Maria Sol; Iglesias-Bartolome, Ramiro; Vaque, Jose P; Molinolo, Alfredo A; Rodrigues, Murilo; Zaidi, M Raza; Ksander, Bruce R; Merlino, Glenn; Sodhi, Akrit; Chen, Qianming; Gutkind, J Silvio

2014-06-16

Mutually exclusive activating mutations in the GNAQ and GNA11 oncogenes, encoding heterotrimeric Gαq family members, have been identified in ∼ 83% and ∼ 6% of uveal and skin melanomas, respectively. However, the molecular events underlying these GNAQ-driven malignancies are not yet defined, thus limiting the ability to develop cancer-targeted therapies. Here, we focused on the transcriptional coactivator YAP, a critical component of the Hippo signaling pathway that controls organ size. We found that Gαq stimulates YAP through a Trio-Rho/Rac signaling circuitry promoting actin polymerization, independently of phospholipase Cβ and the canonical Hippo pathway. Furthermore, we show that Gαq promotes the YAP-dependent growth of uveal melanoma cells, thereby identifying YAP as a suitable therapeutic target in uveal melanoma, a GNAQ/GNA11-initiated human malignancy. Copyright © 2014 Elsevier Inc. All rights reserved.

14 CFR 152.109 - Project eligibility: Airport planning.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Project eligibility: Airport planning. 152....109 Project eligibility: Airport planning. (a) Airport master planning. A proposed project for airport master planning is not approved unless— (1) The location of the existing or proposed airport is included...

Scintillation response of BaF2 and YAlO3:Ce (YAP:Ce) to energetic ions

International Nuclear Information System (INIS)

Slunga, E.; Cederwall, B.; Ideguchi, E.; Kerek, A.; Klamra, W.; Marel, J. van der; Novak, D.; Norlin, L.-O.

2001-01-01

The scintillation response of BaF 2 and YAP:Ce to protons, α particles, 16 O and 28 Si ions in the 5-30 MeV range has been investigated. The ratio between the fast and slow parts of the scintillator signal for BaF 2 has been used to separate protons, α particles and heavier ions, and the dependence of this ratio on the particle energy has been studied. The time constants and intensities of the two components of the YAP:Ce signal were measured, as were the time constant and intensity of the weak component of the slow part of the BaF 2 signal. Furthermore, the dependence of the light yield on the particle energy has been investigated for both BaF 2 and YAP:Ce

Airport Ground Staff Scheduling

DEFF Research Database (Denmark)

Clausen, Tommy

Modern airports are centers of transportation that service a large number of aircraft and passengers every day. To facilitate this large volume of transportation, airports are subject to many logistical and decision problems that must continuously be solved to make sure each flight and passenger ...

Siting Solar Photovoltaics at Airports: Preprint

Energy Technology Data Exchange (ETDEWEB)

Kandt, A.; Romero, R.

2014-06-01

Airports present a significant opportunity for hosting solar technologies due to their open land; based on a 2010 Federal Aviation Administration study, the US Department of Agriculture, and the US Fish and Wildlife Service, there's potential for 116,704 MW of solar photovoltaics (PV) on idle lands at US airports. PV has a low profile and likely low to no impact on flight operations. This paper outlines guidance for implementing solar technologies at airports and airfields, focusing largely on the Federal Aviation Administration's policies. The paper also details best practices for siting solar at airports, provides information on the Solar Glare Hazard Analysis Tool, and highlights a case study example where solar has been installed at an airport.

WW domains of the yes-kinase-associated-protein (YAP transcriptional regulator behave as independent units with different binding preferences for PPxY motif-containing ligands.

Directory of Open Access Journals (Sweden)

Manuel Iglesias-Bexiga

Full Text Available YAP is a WW domain-containing effector of the Hippo tumor suppressor pathway, and the object of heightened interest as a potent oncogene and stemness factor. YAP has two major isoforms that differ in the number of WW domains they harbor. Elucidating the degree of co-operation between these WW domains is important for a full understanding of the molecular function of YAP. We present here a detailed biophysical study of the structural stability and binding properties of the two YAP WW domains aimed at investigating the relationship between both domains in terms of structural stability and partner recognition. We have carried out a calorimetric study of the structural stability of the two YAP WW domains, both isolated and in a tandem configuration, and their interaction with a set of functionally relevant ligands derived from PTCH1 and LATS kinases. We find that the two YAP WW domains behave as independent units with different binding preferences, suggesting that the presence of the second WW domain might contribute to modulate target recognition between the two YAP isoforms. Analysis of structural models and phage-display studies indicate that electrostatic interactions play a critical role in binding specificity. Together, these results are relevant to understand of YAP function and open the door to the design of highly specific ligands of interest to delineate the functional role of each WW domain in YAP signaling.

ORGANIZATIONAL CHANGE FOR THE ENVIRONMENTALLY SUSTAINABLE AIRPORT MANAGEMENT

Directory of Open Access Journals (Sweden)

Vildan Durmaz

2011-11-01

Full Text Available Air transportation industry is a globally growing industry. As an inseparable part of this industry, airport management is also becoming more crucial issue to be dealt with. Airports offer economic and social benefits to the society, but also environmental impacts of airport operations are increasing due to high traffic growth. While airport capacity is increasing, airport operators are being responsible for mitigating environmental constraints. Today to implement airport environmental management system is seen as a critical way of solution. To ensure effective implementation of this system, an organizational change with definite roles, responsibilities and structure are needed. This study illustrates a way of organizational response to market forces and national regulations guiding the achievement of sustainable airports by determining the structure and the roles in an airport organization.

Airport landside operations and air service

Science.gov (United States)

Mandle, P. B.; Whitlock, E. M.; Lamagna, F.; Mundy, R. A.; Oberhausen, P. J.

The following areas are discussed: airport curbside planning and design; analysis of New Orleans airport ground transportation system; time series analysis of intercity air travel volume; economic justification of air service to small communities; and general aviation and the airport and airway system (an analysis of cost allocation and recovery).

78 FR 7476 - Airport Improvement Program

Science.gov (United States)

2013-02-01

... Airports, Airport Planning and Programming, Routing Symbol APP-501, 800 Independence Avenue SW., Room 619... Programming, Routing Symbol APP-501, 800 Independence Avenue SW., Room 619, Washington, DC 20591; between 9 a... recognition of the interest of all segments of the airport community in the AIP. The agency will consider all...

Optimization of airport bus timetable in cultivation period considering passenger dynamic airport choice under conditions of uncertainty

NARCIS (Netherlands)

Lu, J.; Yang, Z.; Timmermans, H.J.P.; Wang, W.

2016-01-01

An airport bus service, which is newly introduced in a multi-airport region, commonly leads to a gradually increasing market share of airports until a new state of equilibrium is reached. With the goal of speeding up and enlarging the increase in market share, this paper proposes a timetable

Emerging Futures for Sao Tome & Principe’s International Airport Campus

Science.gov (United States)

2007-12-03

from Illinois State University and a Culinary Arts degree from New England Culinary Institute. He is currently a research assistallt with the Land...Director. We would also like to thank the College of Fine and Applied Arts and the East St. Louis Action Research Project for their financial contributions...airportS. Reliance on tourism carries risks to the citizens of Sao Tome in the form of cheapening customs and traditions and adaptation of local arts

Airports and Airfields - Volusia County Airports (Points)

Data.gov (United States)

NSGIC Local Govt | GIS Inventory — The Public Use Airports database is a geographic point database of aircraft landing facilities in the United States and U.S. Territories. This database has been...

Airport Configuration Prediction, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — There is presently poor knowledge throughout the National Airspace System (NAS) of the airport configurations currently in use at each airport. There is even less...

β-Catenin destruction complex-independent regulation of Hippo–YAP signaling by APC in intestinal tumorigenesis

Science.gov (United States)

Cai, Jing; Maitra, Anirban; Anders, Robert A.; Taketo, Makoto M.; Pan, Duojia

2015-01-01

Mutations in Adenomatous polyposis coli (APC) underlie familial adenomatous polyposis (FAP), an inherited cancer syndrome characterized by the widespread development of colorectal polyps. APC is best known as a scaffold protein in the β-catenin destruction complex, whose activity is antagonized by canonical Wnt signaling. Whether other effector pathways mediate APC's tumor suppressor function is less clear. Here we report that activation of YAP, the downstream effector of the Hippo signaling pathway, is a general hallmark of tubular adenomas from FAP patients. We show that APC functions as a scaffold protein that facilitates the Hippo kinase cascade by interacting with Sav1 and Lats1. Consistent with the molecular link between APC and the Hippo signaling pathway, genetic analysis reveals that YAP is absolutely required for the development of APC-deficient adenomas. These findings establish Hippo–YAP signaling as a critical effector pathway downstream from APC, independent from its involvement in the β-catenin destruction complex. PMID:26193883

3,3'-[(E-eten-1,2-diil]di(9-heksil-9H-karbazol bileşiğinin sentezi, X-ışını yapı tayini ve teorik yapı tahmini

Directory of Open Access Journals (Sweden)

Erol Asker

2016-08-01

Full Text Available 3,3'-[(E-eten-1,2-diil]di(9-heksil-9H-karbazol bileşiği 9H-karbazoldan çıkarak üç basamakta sentezlenmiş ve yapısı spektroskopik yöntemlerle aydınlatılmıştır. Kristal yapısı monoklinik uzay grubu P21/c'de çözülmüş ve geometrik özellikleri yarı-deneysel PM7 ve teorik DFT/B3LYP hesaplamalarla elde edilen verilerle karşılaştırılmıştır. DFT hesapsal sonuçlar ile X-ışını kırınımı deneysel sonuçlar arasında yüksek korelasyon belirlenmiştir. Kristal yapıdaki moleküller arası etkileşimler hesaplanan öncü orbitallerle açıklanmaya çalışılmıştır.

Airport Casualties: Non-Admission and Return Risks at Times of Internalized/Externalized Border Controls

Directory of Open Access Journals (Sweden)

Maybritt Jill Alpes

2015-09-01

Full Text Available This article analyzes what can happen to forced returnees upon arrival in their country of nationality. Subjective configurations of state agents in the Global South have created return risks, which in turn transform subjectivities of post-colonial citizens. The article contributes to this Special Issue by tracing repercussions of the externalization and internalization of border controls. In the case of Cameroon, these connections have resulted in the criminalization of emigration. Aspiring migrants are prosecuted if their departure projects fail to respect the entry requirements of countries in the Global North. The article is based on research conducted in Douala, Cameroon, in the form of discussions with control agents at the international airport, investigations at a prison, a review of related case law, police registers and interviews with Cameroonians returnees (November 2013–January 2014. Border controls and connected anti-fraud programs suppress family-based forms of solidarity and allow only for subjectivities rooted in state-managed forms of national identity. The article illustrates how efforts to combat fraud fuel corruption in returnees’ social networks, whereby, instead of receiving remittances, families in emigration countries have to mobilize financial resources in order to liberate returnees from police stations or prison complexes. Migration related detention of nationals in the Global South highlights the growing significance of exit controls in migration management.

Influence of Homogenization and Micro/Nano Source of Starting Powders on Format Ion of the Single YAP Phase

Directory of Open Access Journals (Sweden)

Michalik D.

2016-12-01

Full Text Available Manufacturing high purity polycrystalline YAlO3 (YAP ceramics could replace monocrystalline YAP thus recently it is an interesting task for low cost producers of scintillators. The paper presents influence of different source of initial oxide powders (micro/nano powders of Y2O3 and Al2O3 and the method of their homogenization on the formation of a YAP phase. The solid state reaction method was used to prepare YAP powder or ceramic pellets. After preheating, all samples in the form of powders and pellets were heat-treated in the temperature range of 1050-1650 °C. DTA method was applied for examination of the phase crystallization in the tested system. X-ray diffraction method (XRD was used for characterization of the phase composition. X-ray microanalysis (EDS was used to control homogeneity in the small areas. Morphology of the resultant samples are presented on SEM pictures. The results show a significant influence of the starting powders on the homogeneity, purity and temperature of formation of the main phase.

The image of the airport through mobile applications

OpenAIRE

Lázaro Florido-Benítez

2016-01-01

The image airports project via their applications (apps) affects -- directly or indirectly-- passengers’ satisfaction. Today, airports are competing to attract more airlines and passengers to improve commercial revenues. Airport apps (as mobile marketing tools) are offering a broad range of opportunities to both passengers and airports. Apps are the best solution if airports want to improve the passenger experience as well as differentiate themselves from their competitors. The results of thi...

Exploration of the Theoretical Physical Capacity of the John F. Kennedy International Airport Runway System

Science.gov (United States)

Neitzke, Kurt W.; Guerreiro, Nelson M.

2014-01-01

A design study was completed to explore the theoretical physical capacity (TPC) of the John F. Kennedy International Airport (KJFK) runway system for a northflow configuration assuming impedance-free (to throughput) air traffic control functionality. Individual runways were modeled using an agent-based, airspace simulation tool, the Airspace Concept Evaluation System (ACES), with all runways conducting both departures and arrivals on a first-come first-served (FCFS) scheduling basis. A realistic future flight schedule was expanded to 3.5 times the traffic level of a selected baseline day, September 26, 2006, to provide a steady overdemand state for KJFK runways. Rules constraining departure and arrival operations were defined to reflect physical limits beyond which safe operations could no longer be assumed. Safety buffers to account for all sources of operational variability were not included in the TPC estimate. Visual approaches were assumed for all arrivals to minimize inter-arrival spacing. Parallel runway operations were assumed to be independent based on lateral spacing distances. Resulting time intervals between successive airport operations were primarily constrained by same-runway and then by intersecting-runway spacing requirements. The resulting physical runway capacity approximates a theoretical limit that cannot be exceeded without modifying runway interaction assumptions. Comparison with current KJFK operational limits for a north-flow runway configuration indicates a substantial throughput gap of approximately 48%. This gap may be further analyzed to determine which part may be feasibly bridged through the deployment of advanced systems and procedures, and which part cannot, because it is either impossible or not cost-effective to control. Advanced systems for bridging the throughput gap may be conceptualized and simulated using this same experimental setup to estimate the level of gap closure achieved.

Diode-pumped Tm:YAP/YVO4 intracavity Raman laser

International Nuclear Information System (INIS)

Zhao, Jiaqun; Zhou, Xiaofeng; Wang, Guodong; Cheng, Ping; Xu, Feng

2017-01-01

The laser performance based on YVO 4 Raman conversion in a diode-pumped actively Q-switched Tm:YAP laser is demonstrated for the first time. With an incident diode power of 10.9 W and a pulse repetition rate of 1 kHz, the average output powers for the first Stokes laser at 2.4 μm is about 270 mW. (paper)

Prenatal exposure to dietary fat induces changes in the transcriptional factors, TEF and YAP, which may stimulate differentiation of peptide neurons in rat hypothalamus.

Directory of Open Access Journals (Sweden)

Kinning Poon

Full Text Available Gestational exposure to a high-fat diet (HFD stimulates the differentiation of orexigenic peptide-expressing neurons in the hypothalamus of offspring. To examine possible mechanisms that mediate this phenomenon, this study investigated the transcriptional factor, transcription enhancer factor-1 (TEF, and co-activator, Yes-associated protein (YAP, which when inactivated stimulate neuronal differentiation. In rat embryos and postnatal offspring prenatally exposed to a HFD compared to chow, changes in hypothalamic TEF and YAP and their relationship to the orexigenic peptide, enkephalin (ENK, were measured. The HFD offspring at postnatal day 15 (P15 exhibited in the hypothalamic paraventricular nucleus a significant reduction in YAP mRNA and protein, and increased levels of inactive and total TEF protein, with no change in mRNA. Similarly, HFD-exposed embryos at embryonic day 19 (E19 showed in whole hypothalamus significantly decreased levels of YAP mRNA and protein and TEF mRNA, and increased levels of inactive TEF protein, suggesting that HFD inactivates TEF and YAP. This was accompanied by increased density and fluorescence intensity of ENK neurons. A close relationship between TEF and ENK was suggested by the finding that TEF co-localizes with this peptide in hypothalamic neurons and HFD reduced the density of TEF/ENK co-labeled neurons, even while the number and fluorescence intensity of single-labeled TEF neurons were increased. Increased YAP inactivity by HFD was further evidenced by a decrease in number and fluorescence intensity of YAP-containing neurons, although the density of YAP/ENK co-labeled neurons was unaltered. Genetic knockdown of TEF or YAP stimulated ENK expression in hypothalamic neurons, supporting a close relationship between these transcription factors and neuropeptide. These findings suggest that prenatal HFD exposure inactivates both hypothalamic TEF and YAP, by either decreasing their levels or increasing their inactive

Allocation of Ground Handling Resources at Copenhagen Airport

DEFF Research Database (Denmark)

Justesen, Tor Fog

Operating an airport is a very complex task involving many stakeholders. The primary role of airport management is to ensure that the airport provides sufficient capacity in all operational areas and that all the companies carrying out business at the airport have the best possible working...... described here are currently implemented and used in various settings at Copenhagen Airport. These include weekly operational planning of check-in counter allocation and long-term capacity/demand analyses of the airport’s stands and gates....... conditions. Moreover, management must ensure that the airport stays competitive and that its business goals are met to the greatest possible extent. The European Organization for the Safety of Air Navigation (EUROCONTROL) expects demand for air services in Europe to double by 2030 and identifies airport...

76 FR 12408 - Notice of Intent to Rule on Request To Release Airport Property at Ellington Field Airport...

Science.gov (United States)

2011-03-07

... To Release Airport Property at Ellington Field Airport, Houston, Texas AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of request to release airport property. SUMMARY: The FAA proposes to... of Section 125 of the Wendell H. Ford Aviation Investment Reform Act for the 21st Century (AIR 21...

77 FR 39793 - Notice of Intent To Rule on Request To Release Airport Property at Portland-Hillsboro Airport...

Science.gov (United States)

2012-07-05

... To Release Airport Property at Portland--Hillsboro Airport, Hillsboro, OR AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Proposal to Release Airport Property. SUMMARY: The FAA proposes to... provisions of Section 125 of the Wendell H. Ford Aviation Investment Reform Act for the 21st Century (AIR 21...

Concentration and trend of 1,4-dioxane in wells sampled during 2002–2017 in the vicinity of the Tucson International Airport Area Superfund Site, Arizona

Science.gov (United States)

Tillman, Fred D.

2017-09-25

Industrial activities causing extensive groundwater contamination led to the listing of the Tucson International Airport Area (TIAA) as a Superfund Site in 1983. Early groundwater investigations identified volatile organic compounds (VOCs), including the chlorinated solvents trichloroethylene (TCE) and perchloroethylene (PCE), in wells in the area. Several responsible parties were identified and cleanup activities began in the late 1980s. In 2002, the compound 1,4-dioxane was discovered in wells in the area and has since been detected in measurable concentrations throughout the site. The U.S. Environmental Protection Agency (USEPA) classifies 1,4-dioxane as a likely human carcinogen.The purpose of this map is to present 1,4-dioxane concentrations in wells sampled from 2002 through mid-2017 in the TIAA Superfund Site area to indicate both the current status and trends in 1,4-dioxane groundwater contamination. This map includes data from wells in the commercial and residential community in the TIAA and does not include data from wells in suspected or confirmed source areas, such as Air Force Plant 44 and Tucson International Airport, or from wells within treatment facilities.

LIX1 regulates YAP1 activity and controls the proliferation and differentiation of stomach mesenchymal progenitors.

Science.gov (United States)

McKey, Jennifer; Martire, Delphine; de Santa Barbara, Pascal; Faure, Sandrine

2016-04-28

Smooth muscle cell (SMC) plasticity maintains the balance between differentiated SMCs and proliferative mesenchymal progenitors, crucial for muscular tissue homeostasis. Studies on the development of mesenchymal progenitors into SMCs have proven useful in identifying molecular mechanisms involved in digestive musculature plasticity in physiological and pathological conditions. Here, we show that Limb Expression 1 (LIX1) molecularly defines the population of mesenchymal progenitors in the developing stomach. Using in vivo functional approaches in the chick embryo, we demonstrate that LIX1 is a key regulator of stomach SMC development. We show that LIX1 is required for stomach SMC determination to regulate the expression of the pro-proliferative gene YAP1 and mesenchymal cell proliferation. However, as stomach development proceeds, sustained LIX1 expression has a negative impact on further SMC differentiation and this is associated with a decrease in YAP1 activity. We demonstrate that expression of LIX1 must be tightly regulated to allow fine-tuning of the transcript levels and state of activation of the pro-proliferative transcriptional coactivator YAP1 to regulate proliferation rates of stomach mesenchymal progenitors and their differentiation. Our data highlight dual roles for LIX1 and YAP1 and provide new insights into the regulation of cell density-dependent proliferation, which is essential for the development and homeostasis of organs.

Planning, Management, and Economics of Airport Operation

Science.gov (United States)

Wiley, J.

1972-01-01

An overview of the role of the airport in the transportation complex and in the community is presented. The establishment of the airport including its requirements in regional planning and the operation of the airport as a social and economic force are discussed.

The impact of mobile marketing in airport

Directory of Open Access Journals (Sweden)

Lázaro Florido-Benítez

2016-02-01

Full Text Available Purpose: This paper seeks to analyze the effects of mobile marketing tool at airports and passengers. Design/methodology: This research approach consist of going through data files and bibliographical sources in search of information gathered by authors, institutions and organizations regarding our case study. Findings: Mobile marketing to increase passenger satisfaction and commercial income in the airports. Large airports are taking advantage of the consolidation of mobile devices in the 21st century to create applications for branding and communication. Originality/value: This paper is the first research that examines the impact of mobile marketing in airports. First, to evaluate the effects that mobile marketing is having over the levels of passenger satisfaction at airports. Second, to analyze the impact of mobile marketing on passengers behavior in the aerodrome; lastly, to study the effects of this tool on the perceived image of an airport.

76 FR 77383 - Amendment of Class C Airspace; Palm Beach International Airport, FL

Science.gov (United States)

2011-12-13

... benefit LNA traffic that primarily arrives from, or departs to, the west and east of the airport. The... Beach Approach to maneuver, provide better transit to the practice areas to the west and permit straight... above. The dispersal headings vary from 030 to 160 degrees and the southern most heading would exit...

The role of the Yap5 transcription factor in remodeling gene expression in response to Fe bioavailability.

Directory of Open Access Journals (Sweden)

Catarina Pimentel

Full Text Available The budding yeast Saccharomyces cerevisiae has developed several mechanisms to avoid either the drastic consequences of iron deprivation or the toxic effects of iron excess. In this work, we analysed the global gene expression changes occurring in yeast cells undergoing iron overload. Several genes directly or indirectly involved in iron homeostasis showed altered expression and the relevance of these changes are discussed. Microarray analyses were also performed to identify new targets of the iron responsive factor Yap5. Besides the iron vacuolar transporter CCC1, Yap5 also controls the expression of glutaredoxin GRX4, previously known to be involved in the regulation of Aft1 nuclear localization. Consistently, we show that in the absence of Yap5 Aft1 nuclear exclusion is slightly impaired. These studies provide further evidence that cells control iron homeostasis by using multiple pathways.

Airport Merchandising Using Micro Services Architecture

OpenAIRE

Hari Bhaskar Sankaranarayanan; Viral Rathod

2016-01-01

Airport offers an ecosystem where passengers, airlines, airport, and merchants meet under one roof during travel. During the journey, there is a good amount of time spent by passengers on waiting or transit before boarding the flight. Passengers look for spending that time by shopping, dining, and entertainment. Airport merchants and airlines look for merchandising opportunities to acquire new customers, up-sell, and cross-sell their products and services. Highly pe...

Aviation Impacts on Property Values and Management: The Case of Suvarnabhumi International Airport

Directory of Open Access Journals (Sweden)

Patcharin Limlomwongse Suksmith

2015-07-01

Full Text Available Many countries have developed policies and measures to deal with the external impact of aviation on the wider community. There is, however, often controversy and lack of acceptance of some measures, such as compensation, in the communities affected by aviation. Such measures are often felt to be ineffective and perceived as unfair. A clear and objective model for determining compensation would be helpful to reduce controversy. The objective of this study is therefore to examine the relationship between aviation impacts and property values in the case of Thailand's Suvarnabhumi Airport for application to the possible improvement of compensation packages. Multiple regression analysis was used to determine the relationship between five common impacts of aviation (safety, noise, scenery, air pollution, and traffic and property value change, with data from a survey of sample communities around the airport. The results, both for the overall neighborhood and for separate land used types, show that only noise and air pollution demonstrate significant negative relations with property value. The effect of noise drives a higher impact on property price than the effect of air pollution. The main contribution of this research is to improve developing country compensation models by applied measurement from regression analysis to identify factors with significant impacts, using property value change as proxy to measure the impact of the airport. For example, in the case of Thailand, a compensation model should consider noise and air pollution as the main factors rather than consider only noise contour area. The higher weight on noise should be designed to reflect land use types. Furthermore the market value of property loss should be taken into account when designing a compensation package. The survey and regression method used in this study can be adapted for finding relevant factors and suggesting appropriate compensation for other environmental and

Development of Earthquake Emergency Response Plan for Tribhuvan International Airport, Kathmandu, Nepal

Science.gov (United States)

2013-02-01

Prince, Haiti. The consequences for Nepal if a comparable or bigger disaster happens in Kathmandu would likely be worse than in Port–au-Prince because the...procedures adopted in other countries. The framework was made compatible with ICAO standards and TIA’s current existing emergency plan for other...Flight Rules (VFR) in daylight and Instrument Flight Rule ( IFR ). A. Restore Airport Perimeter Security B. Restore Flight Operations a

Airports and Navigation Aids Database System -

Data.gov (United States)

Department of Transportation — Airport and Navigation Aids Database System is the repository of aeronautical data related to airports, runways, lighting, NAVAID and their components, obstacles, no...

Scarcity rents and airport charges

NARCIS (Netherlands)

Burghouwt, G.; de Wit, W.

2015-01-01

This report addresses the responses related to scarcity rents and airport charges. The Commission has asked ITF/SEO to provide evidence on scarcity rents in the London airport system. Different reports submitted in response to the Commission’s consultation make different assumptions on the way

Particulate matter pollution from aviation-related activity at a small airport of the Aegean Sea Insular Region.

Science.gov (United States)

Psanis, C; Triantafyllou, E; Giamarelou, M; Manousakas, M; Eleftheriadis, K; Biskos, G

2017-10-15

The unprecedented growth in aviation during the last years has resulted in a notable increase of local air pollution related to airports. The impacts of aviation on air quality can be extremely high particularly around airports serving remote insular regions with pristine atmospheric environments. Here we report measurements that show how the atmospheric aerosol is affected by the activity at a small airport in a remote region. More specifically, we provide measurements performed at the airport of Mytilene, Greece, a regional yet international airport that serves the entire island of Lesvos; the third largest island of the country. The measurements show that the activity during landing, taxiing and take-off of the aircrafts accounted for up to a 10-fold increase in particulate matter (PM) mass concentration in the vicinity of the airport. The number concentration of particles having diameters from 10 to 500nm also increased from ca. 4×10 2 to 8×10 5 particlescm -3 , while the mean particle diameter decreased to 20nm when aircrafts were present at the airport. Elemental analysis on particle samples collected simultaneously at the airport and at a remote site 3km away, showed that the former were significantly influenced by combustion sources, and specifically from the engines of the aircrafts. Our results show that despite their small size, local airports serving remote insular regions should be considered as important air pollution hotspots, raising concerns for the exposure of the people working and leaving in their vicinities to hazardous pollutants. Copyright © 2017 Elsevier B.V. All rights reserved.

Growth and scintillation properties of Pr doped YAP with different Pr concentrations

International Nuclear Information System (INIS)

Yanagida, Takayuki; Kamada, Kei; Fujimoto, Yutaka; Sugiyama, Makoto; Furuya, Yuki; Yamaji, Akihiro; Yokota, Yuui; Yoshikawa, Akira

2010-01-01

Pr 3+ 0.2, 0.75, and 3 mol% doped YAP single crystalline scintillators were grown by using the micro-pulling down (μ-PD) method. Pr 3+ 0.05 mol% doped YAP was also prepared by using the Czochralski method. In transmittance spectra, 4f-5d absorption line appeared at 230 nm. The μ-PD grown crystals showed intense emission at 290 nm while the Czochralski grown one showed an emission peak at 245 nm in radio luminescence spectra under X-ray excitation. Among them, the Czochralski grown one exhibited the highest light yield under 137 Cs 662 keV excitation and the absolute light yield of this sample was estimated to be 20400±2000 ph/MeV. The decay time constants of these scintillators were around 10 ns due to Pr 3+ 5d-4f transition.

Growth and scintillation properties of Pr doped YAP with different Pr concentrations

Energy Technology Data Exchange (ETDEWEB)

Yanagida, Takayuki, E-mail: t_yanagi@tagen.tohoku.ac.j [Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577 (Japan); Kamada, Kei; Fujimoto, Yutaka; Sugiyama, Makoto; Furuya, Yuki [Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577 (Japan); Yamaji, Akihiro [New Industry Creation Hatchery Center (NICHe), Tohoku University, 6-6-10 Aoba, Aramaki, Aoba-ku, Sendai 980-8579 (Japan); Yokota, Yuui [Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577 (Japan); Yoshikawa, Akira [Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577 (Japan); New Industry Creation Hatchery Center (NICHe), Tohoku University, 6-6-10 Aoba, Aramaki, Aoba-ku, Sendai 980-8579 (Japan)

2010-11-21

Pr{sup 3+} 0.2, 0.75, and 3 mol% doped YAP single crystalline scintillators were grown by using the micro-pulling down ({mu}-PD) method. Pr{sup 3+} 0.05 mol% doped YAP was also prepared by using the Czochralski method. In transmittance spectra, 4f-5d absorption line appeared at 230 nm. The {mu}-PD grown crystals showed intense emission at 290 nm while the Czochralski grown one showed an emission peak at 245 nm in radio luminescence spectra under X-ray excitation. Among them, the Czochralski grown one exhibited the highest light yield under {sup 137}Cs 662 keV excitation and the absolute light yield of this sample was estimated to be 20400{+-}2000 ph/MeV. The decay time constants of these scintillators were around 10 ns due to Pr{sup 3+} 5d-4f transition.

78 FR 20168 - Notice of Intent To Rule on Request To Release Airport Property at the Boulder Municipal Airport...

Science.gov (United States)

2013-04-03

... To Release Airport Property at the Boulder Municipal Airport, Boulder, CO AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of request to release airport property. SUMMARY: The FAA proposes to... of Section 125 of the Wendell H. Ford Aviation Investment Reform Act for the 21st Century (AIR 21...

Copenhagen Airport Cohort

DEFF Research Database (Denmark)

Møller, Karina Lauenborg; Brauer, Charlotte; Mikkelsen, Sigurd

2017-01-01

TO DATE: The cohort includes environmental Global Positioning System (GPS) measurements in Copenhagen Airport, information on job function/task for each calendar year of employment between 1990 and 2012, exposure to air pollution at residence, average weight of baggage lifted per day and lifestyle...... covers 69 175 men in unskilled positions. The exposed cohort includes men in unskilled jobs employed at Copenhagen Airport in the period 1990-2012 either as baggage handlers or in other outdoor work. The reference cohort includes men in unskilled jobs working in the greater Copenhagen area. FINDINGS...

Airport industry connectivity report: 2015

NARCIS (Netherlands)

Boonekamp, T.; Lieshout, R.; Burghouwt, G.

2015-01-01

This report is an update of the 'Airport Industry Connectivity Report 2004-2014'. It's focused on more recent developments and charting how Europe’s connectivity has evolved over the past 12 months. Airport connectivity is an increasingly discussed topic in European policy circles. With good reason.

75 FR 58019 - Notice of Intent to Rule on Request to Release Airport Property at the Kearney Municipal Airport...

Science.gov (United States)

2010-09-23

... to Release Airport Property at the Kearney Municipal Airport, Kearney, NE AGENCY: Federal Aviation Administration, (FAA), DOT. ACTION: Notice of Request to Release Airport Property. SUMMARY: The FAA proposes to... provisions of Section 125 of the Wendell H. Ford Aviation Investment Reform Act for the 21st Century (AIR 21...

76 FR 20071 - Notice of Intent To Rule on Request To Release Airport Property at the Burnet Municipal Airport...

Science.gov (United States)

2011-04-11

... To Release Airport Property at the Burnet Municipal Airport, Burnet, TX AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Request To Release Airport Property. SUMMARY: The FAA proposes to... provisions of Section 125 of the Wendell H. Ford Aviation Investment Reform Act for the 21st Century (AIR 21...

75 FR 76778 - Notice of Intent To Rule on Request To Release Airport Property at the Kearney Municipal Airport...

Science.gov (United States)

2010-12-09

... To Release Airport Property at the Kearney Municipal Airport, Kearney, NE AGENCY: Federal Aviation Administration, (FAA), DOT. ACTION: Notice of request to release airport property. SUMMARY: The FAA proposes to... provisions of Section 125 of the Wendell H. Ford Aviation Investment Reform Act for the 21st Century (AIR 21...

Level of service at airport passenger terminals

Directory of Open Access Journals (Sweden)

Tasić Tamara D.

2016-01-01

Full Text Available Airport terminals are designed by level of service standards which are regulated by International Air Transport Association (IATA. Level of service offered to passengers, regarding to the primary processes, is not necessarily equivalent to the level of service perceived by them. The fact that passengers spending longer times in terminals makes the secondary processes more important in passenger experience. Aiming to improving airport attractiveness, and business success, passenger perception is approached by paying close attention. This paper discusses the two aspects of level of service. Concept of level of service used in air traffic industry with purpose of designing and planning of passenger terminal is derived from the Highway Capacity Manual. Subject of the paper regards last changes which have been introduced during 2014. Second part of the paper explains the needs of examining and analyzing passenger perception from the management point of view, and gives overview of methods which are conducted during researches. Similarities and differences are shown among measurements of level of service and perceived level of service, including the importance of these aspects mutual complementing.

Travel time variability and airport accessibility

OpenAIRE

Koster, P.R.; Kroes, E.P.; Verhoef, E.T.

2010-01-01

This discussion paper resulted in a publication in Transportation Research Part B: Methodological (2011). Vol. 45(10), pages 1545-1559. This paper analyses the cost of access travel time variability for air travelers. Reliable access to airports is important since it is likely that the cost of missing a flight is high. First, the determinants of the preferred arrival times at airports are analyzed, including trip purpose, type of airport, flight characteristics, travel experience, type of che...

LD end pumped mode locked and cavity dumped Nd:YAP laser at 1.34 μm

Science.gov (United States)

Wang, X.; Wang, S.; Rhee, H.; Eichler, H. J.; Meister, S.

2011-06-01

We report a LD end pumped actively mode locked, passively Q switched and cavity dumped Nd:YAP laser at 1.34 μm. The dumped output pulse energy of 160 μJ is obtained at a repetition rate of 10 Hz. Passing through a LD end pumped, double-passed Nd:YAP amplifier the pulse energy is amplified to 1.44 mJ. The corresponding amplification factor is 9. Stimulated Raman scattering experiment is taken with a 9 mm long PbWO4 Raman crystal. Maximum of 20% Raman conversion is reached.

The Neurofibromatosis 2 Tumor Suppressor Gene Product, Merlin, Regulates Human Meningioma Cell Growth by Signaling through YAP

Directory of Open Access Journals (Sweden)

Katherine Striedinger

2008-11-01

Full Text Available Neurofibromatosis type 2 (NF2 is an autosomal dominant disorder characterized by the occurrence of schwannomas and meningiomas. Several studies have examined the ability of the NF2 gene product, merlin, to function as a tumor suppressor in diverse cell types; however, little is known about merlin growth regulation in meningiomas. In Drosophila, merlin controls cell proliferation and apoptosis by signaling through the Hippo pathway to inhibit the function of the transcriptional coactivator Yorkie. The Hippo pathway is conserved in mammals. On the basis of these observations, we developed human meningioma cell lines matched for merlin expression to evaluate merlin growth regulation and investigate the relationship between NF2 status and Yes-associated protein (YAP, the mammalian homolog of Yorkie. NF2 loss in meningioma cells was associated with loss of contact-dependent growth inhibition, enhanced anchorage-independent growth and increased cell proliferation due to increased S-phase entry. In addition, merlin loss in both meningioma cell lines and primary tumors resulted in increased YAP expression and nuclear localization. Finally, siRNA-mediated reduction of YAP in NF2-deficient meningioma cells rescued the effects of merlin loss on cell proliferation and S-phase entry. Collectively, these results represent the first demonstration that merlin regulates cell growth in human cancer cells by suppressing YAP.

Airport Improvement Program (AIP) : reauthorization issues for Congress

Science.gov (United States)

2010-01-01

This report discusses the Airport Improvement Program and its complement, the PFC, within the broader context of airport capital development finance.5 After a brief history of federal support for airport construction and improvement, the report descr...

Targeting Signaling to YAP for the Therapy of NF2

Science.gov (United States)

2016-12-01

nucleus, thus activating YAP-driven transcription and oncogenesis. Genetic epistasis experiments provided evidence that this oncogenic pathway...which loss of Merlin activates mitogenic signaling by using somatic cell genetics and biochemistry. In addition, we have initiated high-throughput...which represents the ultimate long term goal of this grant. Although our studies have identified a critical role for nuclear Merlin in inhibition of

Fbxw7 Deletion Accelerates KrasG12D-Driven Pancreatic Tumorigenesis via Yap Accumulation.

Science.gov (United States)

Zhang, Qiang; Zhang, Yaqing; Parsels, Joshua D; Lohse, Ines; Lawrence, Theodore S; Pasca di Magliano, Marina; Sun, Yi; Morgan, Meredith A

2016-11-01

Pancreatic cancers driven by KRAS mutations require additional mutations for tumor progression. The tumor suppressor FBXW7 is altered in pancreatic cancers, but its contribution to pancreatic tumorigenesis is unknown. To determine potential cooperation between Kras mutation and Fbxw7 inactivation in pancreatic tumorigenesis, we generated P48-Cre;LSL-Kras G12D ;Fbxw7 fl/fl (KFC fl/fl ) compound mice. We found that KFC fl/fl mice displayed accelerated tumorigenesis: all mice succumbed to pancreatic ductal adenocarcinoma (PDA) by 40 days of age, with PDA onset occurring by 2 weeks of age. PDA in KFC fl/fl mice was preceded by earlier onset of acinar-to-ductal metaplasia (ADM) and pancreatic intraepithelial neoplasia (PanIN) lesions, and associated with chromosomal instability and the accumulation of Fbxw7 substrates Yes-associated protein (Yap), c-Myc, and Notch. Using KFC fl/fl and FBXW7-deficient human pancreatic cancer cells, we found that Yap silencing attenuated growth promotion by Fbxw7 deletion. Our data demonstrate that Fbxw7 is a potent suppressor of Kras G12D -induced pancreatic tumorigenesis due, at least in part, to negative regulation of Yap. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

A full Monte Carlo simulation of the YAP-PEM prototype for breast tumor detection

Science.gov (United States)

Motta, A.; Righi, S.; Del Guerra, A.; Belcari, N.; Vaiano, A.; De Domenico, G.; Zavattini, G.; Campanini, R.; Lanconelli, N.; Riccardi, A.

2004-07-01

A prototype for Positron Emission Mammography, the YAP-PEM, is under development within a collaboration of the Italian Universities of Pisa, Ferrara, and Bologna. The aim is to detect breast lesions, with dimensions of 5 mm in diameter, and with a specific activity ratio of 10:1 between the cancer and breast tissue. The YAP-PEM is composed of two stationary detection heads of 6×6 cm 2, composed of a matrix of 30×30 YAP:Ce finger crystals of 2×2×30 mm 3 each. The EGSnrc Monte Carlo code has been used to simulate several characteristics of the prototype. A fast EM algorithm has been adapted to reconstruct all of the collected lines of flight, also at large incidence angles, by achieving 3D positioning capability of the lesion in the FOV. The role of the breast compression has been studied. The performed study shows that a 5 mm diameter tumor of 37 kBq/cm 3 (1 μCi/cm 3), embedded in active breast tissue with 10:1 tumor/background specific activity ratio, is detected in 10 min with a Signal-to-Noise Ratio of 8.7±1.0. Two hot lesions in the active breast phantom are clearly visible in the reconstructed image.

14 CFR 152.325 - Financial status report: Airport planning.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Financial status report: Airport planning... agency conducting a project for airport system planning shall submit a financial status report on a form... TRANSPORTATION (CONTINUED) AIRPORTS AIRPORT AID PROGRAM Accounting and Reporting Requirements § 152.325 Financial...

An Algorithm for the Nucleolus of Airport Profit Problems

NARCIS (Netherlands)

Brânzei, R.; Inarra, E.; Tijs, S.H.; Zarzuelo, J.

2003-01-01

Airport profit games are a generalization of airport cost games as well as of bankruptcy games.In this paper we present a simple algorithm to compute the nucleolus of airport profit games.In addition we prove that there exists an unique consistent allocation rule in airport profit problems, and it

78 FR 32699 - Notice of Intent To Rule on Request to Release Airport Property at the Fort Worth Spinks Airport...

Science.gov (United States)

2013-05-31

... to Release Airport Property at the Fort Worth Spinks Airport, Fort Worth, Texas AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of request to release airport property. SUMMARY: The FAA... the provisions of Section 125 of the Wendell H. Ford Aviation Investment Reform Act for the 21st...

The Aviation System Analysis Capability Airport Capacity and Delay Models

Science.gov (United States)

Lee, David A.; Nelson, Caroline; Shapiro, Gerald

1998-01-01

The ASAC Airport Capacity Model and the ASAC Airport Delay Model support analyses of technologies addressing airport capacity. NASA's Aviation System Analysis Capability (ASAC) Airport Capacity Model estimates the capacity of an airport as a function of weather, Federal Aviation Administration (FAA) procedures, traffic characteristics, and the level of technology available. Airport capacity is presented as a Pareto frontier of arrivals per hour versus departures per hour. The ASAC Airport Delay Model allows the user to estimate the minutes of arrival delay for an airport, given its (weather dependent) capacity. Historical weather observations and demand patterns are provided by ASAC as inputs to the delay model. The ASAC economic models can translate a reduction in delay minutes into benefit dollars.

Studies of scintillation light nonproportionality of ZnSe(Te), CsI(Tl) and YAP(Ce) crystals using heavy ions

CERN Document Server

Klamra, W; Kapusta, M; Kérek, A; Moszynski, M; Norlin, L O; Novák, D; Possnert, G

2002-01-01

The scintillation light yield for ZnSe(Te), CsI(Tl) and YAP(Ce) crystals have been studied with alpha particles, sup 1 sup 2 C and sup 8 sup 1 Br in the energy region 2.8-42.2 MeV. A nonproportional behavior was observed, mostly pronounced for alpha particles on YAP(Ce). The results are understood in terms of delta-rays effect.

Deterministic decomposition and seasonal ARIMA time series models applied to airport noise forecasting

Science.gov (United States)

Guarnaccia, Claudio; Quartieri, Joseph; Tepedino, Carmine

2017-06-01

One of the most hazardous physical polluting agents, considering their effects on human health, is acoustical noise. Airports are a strong source of acoustical noise, due to the airplanes turbines, to the aero-dynamical noise of transits, to the acceleration or the breaking during the take-off and landing phases of aircrafts, to the road traffic around the airport, etc.. The monitoring and the prediction of the acoustical level emitted by airports can be very useful to assess the impact on human health and activities. In the airports noise scenario, thanks to flights scheduling, the predominant sources may have a periodic behaviour. Thus, a Time Series Analysis approach can be adopted, considering that a general trend and a seasonal behaviour can be highlighted and used to build a predictive model. In this paper, two different approaches are adopted, thus two predictive models are constructed and tested. The first model is based on deterministic decomposition and is built composing the trend, that is the long term behaviour, the seasonality, that is the periodic component, and the random variations. The second model is based on seasonal autoregressive moving average, and it belongs to the stochastic class of models. The two different models are fitted on an acoustical level dataset collected close to the Nice (France) international airport. Results will be encouraging and will show good prediction performances of both the adopted strategies. A residual analysis is performed, in order to quantify the forecasting error features.

Role of Air Cargo and Road Feeder Services for Regional Airports – Case Studies from the Baltic Sea Region

Directory of Open Access Journals (Sweden)

Beifert Anatoli

2016-06-01

Full Text Available Although airports play an important role the global and European economies, according to the new guidelines of the EU Commission on the new state aid rules for a competitive aviation industry (EC, 2014, it will be more difficult for unprofitable airports, to get financial public subsidies in the future. The Commission noted that the majority of regional airports experience severe problems to cover their operative costs, resulting from among other things from overlapping of airports’ catchment areas. The main objective of the above mentioned measures is not to close the regional airports, but to motivate them to operate on cost efficient, profitable and more flexible basis, stating however that and that the most inefficient airports will be still closed. In order face upcoming challenges, the regional airports shall reconsider their future development plans. Traditionally, the airports including small and regional airports focus on the passenger traffic and thus, the possible benefits and opportunities of the air cargo market are totally underestimated or even completely ignored. Most regional airports in the Baltic Sea region act totally isolated and do not have a clear picture of the current situation on the international air cargo market today, its future perspectives and sustainable development plans remain basically hidden. There are some examples when trying to meet the market demand, the regional airports have made huge, but unfortunately unjustified investments, e.g. improving airport infrastructure, runways, etc. However, the airports’ infrastructural investments alone cannot fulfil the expected “remedy” role for the airports’ sustainability. This paper aims at investigating the positioning and the role of the regional airports in the current hub-and-spoke network, focusing on the relevance and potential of the air cargo sector for the regional airports development. The optional freight value proposition for the development of

77 FR 59035 - Notice of Intent To Rule on Request To Release Airport Property at the St. George Airport, St...

Science.gov (United States)

2012-09-25

... To Release Airport Property at the St. George Airport, St. George, UT AGENCY: Federal Aviation... rule and invite public comment on the release of land at St. George Airport under the provisions of..., City of St. George, Utah, at the following address: Mr. Gary Esplin, City Manager, City of St. George...

State of the art: Asphalt for airport pavement surfacing

Directory of Open Access Journals (Sweden)

Greg White

2018-01-01

Full Text Available Airport runways and taxiways are commonly comprised of a flexible pavement with an asphalt surface. Marshall-designed asphalt with sawn grooves is the most frequent airport asphalt surface material. However, some airports have adopted alternate asphalt mixtures for improved resistance to shear stress and for increased surface texture, allowing grooving to be avoided. Of the alternate asphalt mixtures, stone mastic asphalt is the most commonly reported. Resistance to shear stress is a critical performance requirement for airport surface asphalt. Shear stress resistance minimises the risk of rutting, shoving and groove closure. However, fracture resistance must not be ignored when developing even more shear resistance asphalt mixtures. Significant distress in airport asphalt surfaces, compliant with the traditional prescriptive specification, has increased interest in a performance-based airport asphalt specification. Commonly reported distresses include groove closure in slow moving aircraft areas and shearing in heavy aircraft braking zones. Development of reliable performance-indicative test methods is expected in the future and will enable warranted performance-based asphalt mixture design for airport surfaces. Keywords: Airport, Pavement, Asphalt, Surface

The dynamic spatial impact of Amsterdam Airport Schiphol

NARCIS (Netherlands)

Warffemius, P.; van der Hoorn, T.; Klaassen, H.

2008-01-01

This paper is about the agglomeration effect of Amsterdam Airport Schiphol and its implications for location policy regarding the airport region. We focus on a specific case, namely the important concentration of European Distribution Centers (EDCs) around the airport. The traditional answer to the

14 CFR 152.113 - Application requirements: Airport planning.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Application requirements: Airport planning....113 Application requirements: Airport planning. (a) Application for Federal assistance. An eligible sponsor or planning agency that desires to obtain Federal aid for eligible airport master planning or...

WIP-YAP/TAZ as A New Pro-Oncogenic Pathway in Glioma

Directory of Open Access Journals (Sweden)

Sergio Rivas

2018-06-01

Full Text Available Wild-type p53 (wtp53 is described as a tumour suppressor gene, and mutations in p53 occur in many human cancers. Indeed, in high-grade malignant glioma, numerous molecular genetics studies have established central roles of RTK-PI3K-PTEN and ARF-MDM2-p53 INK4a-RB pathways in promoting oncogenic capacity. Deregulation of these signalling pathways, among others, drives changes in the glial/stem cell state and environment that permit autonomous growth. The initially transformed cell may undergo subsequent modifications, acquiring a more complete tumour-initiating phenotype responsible for disease advancement to stages that are more aggressive. We recently established that the oncogenic activity of mutant p53 (mtp53 is driven by the actin cytoskeleton-associated protein WIP (WASP-interacting protein, correlated with tumour growth, and more importantly that both proteins are responsible for the tumour-initiating cell phenotype. We reported that WIP knockdown in mtp53-expressing glioblastoma greatly reduced proliferation and growth capacity of cancer stem cell (CSC-like cells and decreased CSC-like markers, such as hyaluronic acid receptor (CD44, prominin-1 (CD133, yes-associated protein (YAP and transcriptional co-activator with PDZ-binding motif (TAZ. We thus propose a new CSC signalling pathway downstream of mtp53 in which Akt regulates WIP and controls YAP/TAZ stability. WIP drives a mechanism that stimulates growth signals, promoting YAP/TAZ and β-catenin stability in a Hippo-independent fashion, which allows cells to coordinate processes such as proliferation, stemness and invasiveness, which are key factors in cancer progression. Based on this multistep tumourigenic model, it is tantalizing to propose that WIP inhibitors may be applied as an effective anti-cancer therapy.

Elevated YAP and its downstream targets CCN1 and CCN2 in basal cell carcinoma: impact on keratinocyte proliferation and stromal cell activation.

Science.gov (United States)

Quan, Taihao; Xu, Yiru; Qin, Zhaoping; Robichaud, Patrick; Betcher, Stephanie; Calderone, Ken; He, Tianyuan; Johnson, Timothy M; Voorhees, John J; Fisher, Gary J

2014-04-01

Yes-associated protein (YAP) is a transcriptional co-activator of hippo signaling pathway, which plays an important role in organ size control and tumorigenesis. Here we report that YAP and its downstream transcriptional targets CCN1 and CCN2 are markedly elevated in keratinocytes in human skin basal cell carcinoma tumor islands. In human keratinocytes, knockdown of YAP significantly reduced expression of CCN1 and CCN2, and repressed proliferation and survival. This inhibition of proliferation and survival was rescued by restoration of CCN1 expression, but not by CCN2 expression. In basal cell carcinoma stroma, CCN2-regulated genes type I collagen, fibronectin, and α-smooth muscle actin were highly expressed. Furthermore, atomic force microscopy revealed increased tissue stiffness in basal cell carcinoma stroma compared to normal dermis. These data provide evidence that up-regulation of YAP in basal cell carcinoma impacts both aberrant keratinocyte proliferation, via CCN1, and tumor stroma cell activation and stroma remodeling, via CCN2. Targeting YAP and/or CCN1 and CCN2 may provide clinical benefit in basal cell carcinoma. Copyright © 2014 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

Airport Screening

Science.gov (United States)

Health Physics Society Specialists in Radiation Safety Airport Screening Fact Sheet Adopted: May 2011 Photo courtesy of Dan ... a safe level. An American National Standards Institute/Health Physics Society industry standard states that the maxi- mum ...

Virtual queuing at airport security lanes

NARCIS (Netherlands)

Lange, de R.; Samoilovich, I.; Rhee, van der B.

2013-01-01

Airports continuously seek opportunities to reduce the security costs without negatively affecting passenger satisfaction. In this paper, we investigate the possibilities of implementing virtual queuing at airport security lanes, by offering some passengers a time window during which they can arrive

Airport level of service: A model according to departing passengers’ perceptions at a small-sized airport

Directory of Open Access Journals (Sweden)

Max Well Elias Gonçalves

2017-04-01

Full Text Available Purpose: This study proposes a conceptual model of level of service evaluation to a small-sized airport with a focus on departing passengers. Design/Methodology: The variables selected to compose the model were chosen according to their adequacy to departing passengers and the airport’s characteristics. A survey was conducted, and, posteriorly, exploratory factor analysis was used in order to verify the adequacy of the conceptual model proposed and also to improve it according to the results obtained. Findings: The results show that the level of service of the airport is composed of three dimensions: airport characteristics, passenger processing, and prices. The relative importance of the dimensions according to their contribution to the composition of the airport’s overall level of service was also determined. Originality/value: The paper combines theoretical and practical findings in a model for level of service evaluation to a small-sized airport from an air transportation management perspective.

Peynir Yapımında Mikrobiyal Renet Kullanımı

Directory of Open Access Journals (Sweden)

Mehmet Karapınar

2015-02-01

Full Text Available Peynir yapımında süt koagulantı olarak buzağı reneti yerine kullanılmak üzere proteazlar üzerine yapılan çalışmalar son yıllarda yoğunluk kazanmıştır. Günümüzde buzağı reneti standart bir süt koagulantı olarak önemini sürdürmekteyse de, şirden mayası üretimi her yıl giderek gereksinimi karşılayamaz duruma gelmektedir. Bunun sonucu olarak yeni renet kaynakları arasında yoğunlaşmış ve günümüzde Mucor pusillus, M. miehei, Endothia parasitica küf türlerinden elde edilen üç fungal enzim ile Bacillus cereus bakterisinden elde edilen bir bakteriyel enzim ticari olarak üretilmeye başlanmıştır.

The impact of mobile marketing in airports

OpenAIRE

Florido-Benítez, Lázaro

2016-01-01

Purpose: This paper seeks to analyze the effects of mobile marketing tool at airports and passengers. Design/methodology: This research approach consist of going through data files and bibliographical sources in search of information gathered by authors, institutions and organizations regarding our case study. Findings: Mobile marketing to increase passenger satisfaction and commercial income in the airports. Large airports are taking advantage of the consolidation of mobile devic...

14 CFR 152.323 - Budget revision: Airport development.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Budget revision: Airport development. 152... TRANSPORTATION (CONTINUED) AIRPORTS AIRPORT AID PROGRAM Accounting and Reporting Requirements § 152.323 Budget... change in the budget estimates, the sponsor shall submit a request for budget revision on a form...

Measuring the size of an airport's catchment area

NARCIS (Netherlands)

Lieshout, R.

2012-01-01

Although much empirical research exists on the factors that drive passenger airport choice, not much is known about the related topic of airport catchment area size. This paper presents a novel methodology to assess the size of airport catchment areas and the airport’s market shares therein using a

Factors influencing passengers’ choice of transport mode to Warsaw Chopin Airport

Directory of Open Access Journals (Sweden)

Górecka Aleksandra

2016-10-01

Full Text Available Airport accessibility is an important factor for airport choice and therefore also for airport competition. When air passengers choose an itinerary, they reflect on the transport chain from door to door. Therefore, factors affecting the traveller’s decision for a particular option go beyond the price and quality of air services from airport to airport. The decision for or against a particular air service and a particular airport is to a certain extent dependent on the accessibility of the airport.

Public Airports

Data.gov (United States)

Earth Data Analysis Center, University of New Mexico — This data set is a vector point digital data structure that contains the locations of General Public Use Airports in the State of New Mexico. It only contains those...

Scheduling of outbound luggage handling at airports

DEFF Research Database (Denmark)

Barth, Torben C.; Pisinger, David

2012-01-01

This article considers the outbound luggage handling problem at airports. The problem is to assign handling facilities to outbound flights and decide about the handling start time. This dynamic, near real-time assignment problem is part of the daily airport operations. Quality, efficiency......). Another solution method is a decomposition approach. The problem is divided into different subproblems and solved in iterative steps. The different solution approaches are tested on real world data from Frankfurt Airport....

Analysis and Modeling of Ground Operations at Hub Airports

Science.gov (United States)

Atkins, Stephen (Technical Monitor); Andersson, Kari; Carr, Francis; Feron, Eric; Hall, William D.

2000-01-01

Building simple and accurate models of hub airports can considerably help one understand airport dynamics, and may provide quantitative estimates of operational airport improvements. In this paper, three models are proposed to capture the dynamics of busy hub airport operations. Two simple queuing models are introduced to capture the taxi-out and taxi-in processes. An integer programming model aimed at representing airline decision-making attempts to capture the dynamics of the aircraft turnaround process. These models can be applied for predictive purposes. They may also be used to evaluate control strategies for improving overall airport efficiency.

Surface Operations Systems Improve Airport Efficiency

Science.gov (United States)

2009-01-01

With Small Business Innovation Research (SBIR) contracts from Ames Research Center, Mosaic ATM of Leesburg, Virginia created software to analyze surface operations at airports. Surface surveillance systems, which report locations every second for thousands of air and ground vehicles, generate massive amounts of data, making gathering and analyzing this information difficult. Mosaic?s Surface Operations Data Analysis and Adaptation (SODAA) tool is an off-line support tool that can analyze how well the airport surface operation is working and can help redesign procedures to improve operations. SODAA helps researchers pinpoint trends and correlations in vast amounts of recorded airport operations data.

Location of airports - selected quantitative methods

Directory of Open Access Journals (Sweden)

Agnieszka Merkisz-Guranowska

2016-09-01

Full Text Available Background: The role of air transport in  the economic development of a country and its regions cannot be overestimated. The decision concerning an airport's location must be in line with the expectations of all the stakeholders involved. This article deals with the issues related to the choice of  sites where airports should be located. Methods: Two main quantitative approaches related to the issue of airport location are presented in this article, i.e. the question of optimizing such a choice and the issue of selecting the location from a predefined set. The former involves mathematical programming and formulating the problem as an optimization task, the latter, however, involves ranking the possible variations. Due to various methodological backgrounds, the authors present the advantages and disadvantages of both approaches and point to the one which currently has its own practical application. Results: Based on real-life examples, the authors present a multi-stage procedure, which renders it possible to solve the problem of airport location. Conclusions: Based on the overview of literature of the subject, the authors point to three types of approach to the issue of airport location which could enable further development of currently applied methods.

A Geometric Fuzzy-Based Approach for Airport Clustering

Directory of Open Access Journals (Sweden)

Maria Nadia Postorino

2014-01-01

Full Text Available Airport classification is a common need in the air transport field due to several purposes—such as resource allocation, identification of crucial nodes, and real-time identification of substitute nodes—which also depend on the involved actors’ expectations. In this paper a fuzzy-based procedure has been proposed to cluster airports by using a fuzzy geometric point of view according to the concept of unit-hypercube. By representing each airport as a point in the given reference metric space, the geometric distance among airports—which corresponds to a measure of similarity—has in fact an intrinsic fuzzy nature due to the airport specific characteristics. The proposed procedure has been applied to a test case concerning the Italian airport network and the obtained results are in line with expectations.

Louisiana Airports, Geographic NAD83, FEMA (1997)[airports_FEMA_1997

Data.gov (United States)

Louisiana Geographic Information Center — This is is a point dataset for the locations and attributes of 20 Louisiana airports. The attributes include name, address, city, county (sic), state, phone,...

Journal of Airline and Airport Management: Taking off on an exciting journey into Air Transport Research

Directory of Open Access Journals (Sweden)

David Gonzalez-Prieto

2011-11-01

Full Text Available We are pleased to introduce this first and inaugural issue of the first volume of the Journal of Airline and Airport Management (JAIRM. JAIRM is an international journal that proposes and fosters discussion on the theory and application in all areas of air transport, including (but not limited to air transport and globalization, airline and airport management. We are interested in issues related to production, logistics, operations, marketing, policy and regulation, information systems, project management, quality, as well as regional development, economics, organizational behaviour, finance and accounting in air transport research.

40 CFR 258.10 - Airport safety.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Airport safety. 258.10 Section 258.10 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES CRITERIA FOR MUNICIPAL SOLID WASTE LANDFILLS Location Restrictions § 258.10 Airport safety. (a) Owners or operators of new...

Preliminary assessment of the imaging capability of the YAP-(S)PET small animal scanner in neuroscience

International Nuclear Information System (INIS)

Bartoli, Antonietta; Belcari, Nicola; Stark, Daniela; Hoehnemann, Sabine; Piel, Markus; Jennewein, Marc; Schmitt, Ulrich; Tillmanns, Julia; Thews, Oliver; Hiemke, Christoph; Roesch, Frank; Del Guerra, Alberto

2006-01-01

The new and fully engineered version of the YAP-(S)PET small animal scanner has been tested at the University of Mainz for preliminary assessment of its imaging capability for studies related to neuropharmacology and psychiatry. The main feature of the scanner is the capability to combine PET and SPECT techniques. It allows the development of new and interesting protocols for the investigation of many biological phenomena, more effectively than with PET or SPECT modalities alone. The scanner is made up of four detector heads, each one composed of a 4x4 cm 2 of YAlO 3 :Ce (or YAP:Ce) matrix, and has a field of view (FOV) of 4 cm axiallyx4 cm o transaxially. In PET mode, the volume resolution is less than 8 mm 3 and is nearly constant over the whole FOV, while the sensitivity is about 2%. The SPECT performance is not so good, due to the presence of the multi-hole lead collimator in front of each head. Nevertheless, the YAP-PET scanner offers excellent resolution and sensitivity for performing on the availability of D2-like dopamine receptors on mice and rats in both PET and SPECT modalities

46 CFR 72.05-30 - Windows and airports.

Science.gov (United States)

2010-10-01

... 46 Shipping 3 2010-10-01 2010-10-01 false Windows and airports. 72.05-30 Section 72.05-30 Shipping... Structural Fire Protection § 72.05-30 Windows and airports. (a) For the purpose of this subpart, all glass in windows or airports shall be at least 1/4 inch thick. However, greater thickness may be required for...

INNOVATION OF AIRPORTS AND AERODROMES IN TRANSPORT

Directory of Open Access Journals (Sweden)

Tomasz BALCERZAK

2016-03-01

Full Text Available The paper attempts to characterize changes occurring in EU transport policy, taking into account innovation of airports and aerodromes. To face challenges like: increase in air traffic, ensuring safety of flight operations, regional development or requirements of passengers it is necessary to determine desired direction network of airports and aerodromes within the aviation policy, which is part of the national and European transport policy. Overview of national and EU studies, strategies and legislative plans enable to specify changes taking place in the EU aviation policy, as well as to create potential scenarios of its development with particular attention to the innovation of aerodromes and airports. Based on the above analysis it should be noted, that aims of the European institutions and agencies are: reduction amount of restrictive rules on general aviation (including GA aerodromes, spread concepts of multimodality and Small Aircraft Transport Systems, enhance competitiveness of the EU aviation sector but also reduction investment funding at airports. Conclusions may be a theoretical inspiration in the process of updating master plans of aerodromes and airports.

Travel time variability and airport accessibility

NARCIS (Netherlands)

Koster, P.R.; Kroes, E.P.; Verhoef, E.T.

2011-01-01

We analyze the cost of access travel time variability for air travelers. Reliable access to airports is important since the cost of missing a flight is likely to be high. First, the determinants of the preferred arrival times at airports are analyzed. Second, the willingness to pay (WTP) for

Aircraft noise in the region of the Bucharest-Otopeni Airport. [noise pollution in airport environment

Science.gov (United States)

Costescu, M.; Gherghel, C.; Curtoglu, A.

1974-01-01

Aircraft noise, especially in the region adjoining airports, constitutes a problem that will be aggravated in the near future because of increasing aircraft traffic and the appearance of new types of large tonnage aircraft with continuously increasing powers and speeds. Criteria for the evaluation of aircraft noise are reported and some results of studies carried out in the region of Bucharest-Otopeni Airport are detailed.

Measuring and Explaining Airport Efficiency and Sustainability: Evidence from Italy

Directory of Open Access Journals (Sweden)

Fabio Carlucci

2018-02-01

Full Text Available From an environmental point of view, it is widely recognized in economic literature that an efficient management of regional airports produces positive effects both for congestion reduction in the larger airports and for better use of existing infrastructures. Regional airports generally suffer from economic vulnerabilities because of scarcity of traffic volume; besides, their small catchment areas often determine low cash flow levels. As a result, significant problems of economic sustainability arise. In this context, airport infrastructure providers have the incentive to hide failures in their strategic decisions, justifying the low share of cost recovery through market characteristics. By means of the DEA (Data Envelopment Analysis method this paper analyses overall technical, pure technical, and scale efficiency of 34 Italian airports in the period 2006–2016 in order to investigate how a number of factors impact on the efficiency and economic sustainability of regional airports. Our findings reveal that airport size, presence of low-cost carriers and cargo traffic have a significant influence on the technical and scale efficiency of Italian airports. In other words, air transport privatization and deregulation can positively affect regional airport efficiency and sustainability. This is to say that the market mechanism is a useful tool in achieving regional airport sustainability even if the empirical analysis of the effects of privatization and deregulation is recommended for evaluating such political programs.

Amsterdam's Airport Library Serves Passengers in 30 Languages

Science.gov (United States)

Dempsey, Kathy

2011-01-01

In the summer of 2010, Schiphol Airport in Amsterdam started offering the world's first library in an airport. This article describes Airport Library which is no ordinary library. It holds more than 1,200 items, but it lends nothing. It operates 24/7, yet it's only staffed by volunteers for 2 or 3 hours a day. It offers just nine public-access…

Take-off engine particle emission indices for in-service aircraft at Los Angeles International Airport

Science.gov (United States)

Moore, Richard H.; Shook, Michael A.; Ziemba, Luke D.; Digangi, Joshua P.; Winstead, Edward L.; Rauch, Bastian; Jurkat, Tina; Thornhill, Kenneth L.; Crosbie, Ewan C.; Robinson, Claire; Shingler, Taylor J.; Anderson, Bruce E.

2017-12-01

We present ground-based, advected aircraft engine emissions from flights taking off at Los Angeles International Airport. 275 discrete engine take-off plumes were observed on 18 and 25 May 2014 at a distance of 400 m downwind of the runway. CO2 measurements are used to convert the aerosol data into plume-average emissions indices that are suitable for modelling aircraft emissions. Total and non-volatile particle number EIs are of order 1016-1017 kg-1 and 1014-1016 kg-1, respectively. Black-carbon-equivalent particle mass EIs vary between 175-941 mg kg-1 (except for the GE GEnx engines at 46 mg kg-1). Aircraft tail numbers recorded for each take-off event are used to incorporate aircraft- and engine-specific parameters into the data set. Data acquisition and processing follow standard methods for quality assurance. A unique aspect of the data set is the mapping of aerosol concentration time series to integrated plume EIs, aircraft and engine specifications, and manufacturer-reported engine emissions certifications. The integrated data enable future studies seeking to understand and model aircraft emissions and their impact on air quality.

Take-off engine particle emission indices for in-service aircraft at Los Angeles International Airport.

Science.gov (United States)

Moore, Richard H; Shook, Michael A; Ziemba, Luke D; DiGangi, Joshua P; Winstead, Edward L; Rauch, Bastian; Jurkat, Tina; Thornhill, Kenneth L; Crosbie, Ewan C; Robinson, Claire; Shingler, Taylor J; Anderson, Bruce E

2017-12-19

We present ground-based, advected aircraft engine emissions from flights taking off at Los Angeles International Airport. 275 discrete engine take-off plumes were observed on 18 and 25 May 2014 at a distance of 400 m downwind of the runway. CO 2 measurements are used to convert the aerosol data into plume-average emissions indices that are suitable for modelling aircraft emissions. Total and non-volatile particle number EIs are of order 10 16 -10 17 kg -1 and 10 14 -10 16 kg -1 , respectively. Black-carbon-equivalent particle mass EIs vary between 175-941 mg kg -1 (except for the GE GEnx engines at 46 mg kg -1 ). Aircraft tail numbers recorded for each take-off event are used to incorporate aircraft- and engine-specific parameters into the data set. Data acquisition and processing follow standard methods for quality assurance. A unique aspect of the data set is the mapping of aerosol concentration time series to integrated plume EIs, aircraft and engine specifications, and manufacturer-reported engine emissions certifications. The integrated data enable future studies seeking to understand and model aircraft emissions and their impact on air quality.

Taxi-Out Time Prediction for Departures at Charlotte Airport Using Machine Learning Techniques

Science.gov (United States)

Lee, Hanbong; Malik, Waqar; Jung, Yoon C.

2016-01-01

Predicting the taxi-out times of departures accurately is important for improving airport efficiency and takeoff time predictability. In this paper, we attempt to apply machine learning techniques to actual traffic data at Charlotte Douglas International Airport for taxi-out time prediction. To find the key factors affecting aircraft taxi times, surface surveillance data is first analyzed. From this data analysis, several variables, including terminal concourse, spot, runway, departure fix and weight class, are selected for taxi time prediction. Then, various machine learning methods such as linear regression, support vector machines, k-nearest neighbors, random forest, and neural networks model are applied to actual flight data. Different traffic flow and weather conditions at Charlotte airport are also taken into account for more accurate prediction. The taxi-out time prediction results show that linear regression and random forest techniques can provide the most accurate prediction in terms of root-mean-square errors. We also discuss the operational complexity and uncertainties that make it difficult to predict the taxi times accurately.

Application of the methodology for improving the business processes for the compamy for Airport services TAV Airports Holding, Macedonia

OpenAIRE

Mitreva, Elizabeta; Taskov, Nako; Lazarovski, Zlatko

2015-01-01

In this paper we will make a full diagnosis of some business processes in the company for Airport services TAV Airports Holding, Macedonia. Based on the analysis we have made on the existing quality system an appropriate methodology is designed for each feature of the TQM (Total Quality Management) system in order to find the optimal solution for smooth operation of the airport traffic, in order to meet the wishes and needs of the customer, while the company makes a profit. The methodol...

76 FR 21420 - Policy and Procedures Concerning the Use of Airport Revenue; Policy Regarding Airport Rates and...

Science.gov (United States)

2011-04-15

... airport destination not currently served, (b) nonstop service where no nonstop service is currently offered, (c) new entrant carrier, and/or (d) increased frequency of flights to a specific destination. The... assistance in marketing new service; and a subsidy of air service if airport revenue is not used for that...

Aquatic toxicity of airfield-pavement deicer materials and implications for airport runoff

Science.gov (United States)

Corsi, S.R.; Geis, S.W.; Bowman, G.; Failey, G.G.; Rutter, T.D.

2009-01-01

Concentrations of airfield-pavement deicer materials (PDM) in a study of airport runoff often exceeded levels of concern regarding aquatic toxicity. Toxicity tests on Vibrio fischeri, Pimephales promelas, Ceriodaphnia dubia, and Pseudokirchneriella subcapitata (commonly known as Selenastrum capricornutum) were performed with potassium acetate (K-Ac) PDM, sodium formate (Na-For) PDM, and with freezing- point depressants (K-Ac and Na-For). Results indicate that toxicity in PDM is driven by the freezing-point depressants in all tests except the Vibrio fisheri test for Na-For PDM which is influenced by an additive. Acute toxicity end points for different organisms ranged from 298 to 6560 mg/L (as acetate) for K-Ac PDM and from 1780 to 4130 mg/L (as formate) for Na- For PDM. Chronic toxicity end points ranged from 19.9 to 336 mg/L (as acetate) for K-Ac PDM and from 584 to 1670 mg/L (as formate) for Na-For PDM. Sample results from outfalls at General Mitchell International Airport in Milwaukee, Wl (GMIA) indicated that 40% of samples had concentrations greater than the aquatic-life benchmark for K-Ac PDM. K-Ac has replaced urea during the 1990s as the most widely used PDM at GMIA and in the United States. Results of ammonia samples from airport outfalls during periods when urea-based PDM was used at GMIA indicated that41% of samples had concentrations exceeding the U.S. Environmental Protection Agency (USEPA) 1 -h water-quality criterion. The USEPA 1-h water-quality criterion for chloride was exceeded in 68% of samples collected in the receiving stream, a result of road-salt runoff from urban influence near the airport. Results demonstrate that PDM must be considered to comprehensively evaluate the impact of chemical deicers on aquatic toxicity in water containing airport runoff. ?? 2009 American Chemical Society.

YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration

DEFF Research Database (Denmark)

Yui, Shiro; Azzolin, Luca; Maimets, Martti

2018-01-01

by remodeling the extracellular matrix (ECM), increased FAK/Src signaling, and ultimately YAP/TAZ activation. In a defined cell culture system recapitulating the extracellular matrix remodeling observed in vivo, we show that a collagen 3D matrix supplemented with Wnt ligands is sufficient to sustain endogenous...

Northern New Mexico regional airport market feasibility

Energy Technology Data Exchange (ETDEWEB)

Drake, R.H.; Williams, D.S.

1998-06-01

This report is about the market for airline travel in northern New Mexico. Interest in developing a northern New Mexico regional airport has periodically surfaced for a number of years. The New Mexico State Legislature passed a memorial during the 1998 Second Session calling for the conduct of a study to determine the feasibility of building a new regional airport in NNM. This report is a study of the passenger market feasibility of such an airport. In addition to commercial passenger market feasibility, there are other feasibility issues dealing with siting, environmental impact, noise, economic impact, intermodal transportation integration, region-wide transportation services, airport engineering requirements, and others. These other feasibility issues are not analyzed in any depth in this report although none were discovered to be show-stoppers as a by-product of the authors doing research on the passenger market itself. Preceding the need for a detailed study of these other issues is the determination of the basic market need for an airport with regular commercial airline service in the first place. This report is restricted to an in-depth look at the market for commercial passenger air service in NNM. 20 figs., 8 tabs.

Background noise analysis in urban airport surroundings of Brazilian cities, Congonhas Airport, São Paulo

Directory of Open Access Journals (Sweden)

Fabio Scatolini

Full Text Available ABSTRACT OBJECTIVE To perform a quantitative analysis of the background noise at Congonhas Airport surroundings based on large sampling and measurements with no interruption. METHODS Measuring sites were chosen from 62 and 72 DNL (day-night-level noise contours, in urban sites compatible with residential use. Fifteen sites were monitored for at least 168 hours without interruption or seven consecutive days. Data compilation was based on cross-reference between noise measurements and air traffic control records, and results were validated by airport meteorological reports. Preliminary diagnoses were established using the standard NBR-13368. Background noise values were calculated based on the Sound Exposure Level (SEL. Statistic parameters were calculated in one-hour intervals. RESULTS Only four of the fifteen sites assessed presented aircraft operations as a clear cause for the noise annoyance. Even so, it is possible to detect background noise levels above regulation limits during periods of low airport activity or when it closes at night. CONCLUSIONS All the sites monitored showed background noise levels above regulation limits between 7:00 and 21:00. In the intervals between 6:00-6:59 and 21:00-22:59 the noise data, when analyzed with the current airport operational characteristics, still allow the development of additional mitigating measures.

A novel wireless local positioning system for airport (indoor) security

Science.gov (United States)

Zekavat, Seyed A.; Tong, Hui; Tan, Jindong

2004-09-01

A novel wireless local positioning system (WLPS) for airport (or indoor) security is introduced. This system is used by airport (indoor) security guards to locate all of, or a group of airport employees or passengers within the airport area. WLPS consists of two main parts: (1) a base station that is carried by security personnel; hence, introducing dynamic base station (DBS), and (2) a transponder (TRX) that is mounted on all people (including security personnel) present at the airport; thus, introducing them as active targets. In this paper, we (a) draw a futuristic view of the airport security systems, and the flow of information at the airports, (b) investigate the techniques of extending WLPS coverage area beyond the line-of-sight (LoS), and (c) study the performance of this system via standard transceivers, and direct sequence code division multiple access (DS-CDMA) systems with and without antenna arrays and conventional beamforming (BF).

14 CFR 153.5 - Aviation safety inspector airport access.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Aviation safety inspector airport access... TRANSPORTATION (CONTINUED) AIRPORTS AIRPORT OPERATIONS Aviation Safety Inspector Access § 153.5 Aviation safety... must grant Aviation Safety Inspectors bearing FAA Form 110A free and uninterrupted access to public-use...

14 CFR 139.203 - Contents of Airport Certification Manual.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Contents of Airport Certification Manual. 139.203 Section 139.203 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... succession of airport operational responsibility X X X X 2. Each current exemption issued to the airport from...

Analysis and design on airport safety information management system

Directory of Open Access Journals (Sweden)

Yan Lin

2017-01-01

Full Text Available Airport safety information management system is the foundation of implementing safety operation, risk control, safety performance monitor, and safety management decision for the airport. The paper puts forward the architecture of airport safety information management system based on B/S model, focuses on safety information processing flow, designs the functional modules and proposes the supporting conditions for system operation. The system construction is helpful to perfecting the long effect mechanism driven by safety information, continually increasing airport safety management level and control proficiency．

The use of meta-heuristics for airport gate assignment

DEFF Research Database (Denmark)

Cheng, Chun-Hung; Ho, Sin C.; Kwan, Cheuk-Lam

2012-01-01

proposed to generate good solutions within a reasonable timeframe. In this work, we attempt to assess the performance of three meta-heuristics, namely, genetic algorithm (GA), tabu search (TS), simulated annealing (SA) and a hybrid approach based on SA and TS. Flight data from Incheon International Airport...... are collected to carry out the computational comparison. Although the literature has documented these algorithms, this work may be a first attempt to evaluate their performance using a set of realistic flight data....

Analysis of wind data for airport runway design

Directory of Open Access Journals (Sweden)

Roberto Bellasio

2014-09-01

Full Text Available Purpose: To provide a methodology, and examples of application, for analyzing wind data for the correct orientation of airport runways. Design/methodology/approach: More than 90000 observed wind data have been analyzed for each one of the three airports used as case studies. Both observed and estimated gusts have been considered. Findings: If only observed data are considered, each single runway of the three airports used as case studies is correctly oriented. When estimated gusts are considered, the FAA requirements are not satisfied by a single runway in some airports (which anyway satisfy such requirements by using more runways. Practical implications: The correct orientation of runways minimize the crosswind components, then increase the safety of the airports. Originality/value: The paper provides a methodology to evaluate the orientation of existing runways and to design new runways. Such methodology is based on the analysis wind data, considering both observed values and estimated gusts.

Mobile Apps: Improve Airports ́ Brand Image and Differentiate Among Competitors

OpenAIRE

Lázaro Florido-Benítez

2016-01-01

The image airports project via their applications (apps) affects -- directly or indirectly--passengers’ satisfaction. Today, airports are competing among each other to attract more airlines and passengers to improve commercial revenues. Airport apps (as mobile marketing tools) are offering a wide range of opportunities to both passengers and airports. Apps are the best solution if airports want to improve the passenger experience as well as differentiate themselves from their competitors. The...

Waste and energy management at airports. Paper no. IGEC-1-024

International Nuclear Information System (INIS)

Korul, V.; Ozen, M.

2005-01-01

Air transport is a high growth industry. The growth in demand for air transport has had very significant economic and environmental consequences for airlines and airports. With increased traffic, the volume of waste is increasing while the waste at airports is generated by airlines, airport operators and other airport related companies. Waste management is usually under the airport operators' responsibility. Energy management, associated with the provision of heating, ventilation, air conditioning and lighting, is also very important. With energy conservation, as with waste management, there are good financial reasons for why airports should address these issues since environmental improvements may bring about considerable cost savings. This study aims to discuss the environmental issues at airports by giving a global perspective for the sustainability of aviation industry. (author)

Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice.

Science.gov (United States)

Kim, Han-Byul; Kim, Minchul; Park, Young-Soo; Park, Intae; Kim, Tackhoon; Yang, Sung-Yeun; Cho, Charles J; Hwang, DaeHee; Jung, Jin-Hak; Markowitz, Sanford D; Hwang, Sung Wook; Yang, Suk-Kyun; Lim, Dae-Sik; Myung, Seung-Jae

2017-02-01

Prostaglandin E 2 (PGE 2 ) is mediator of inflammation that regulates tissue regeneration, but its continual activation has been associated with carcinogenesis. Little is known about factors in the PGE 2 signaling pathway that contribute to tumor formation. We investigated whether yes-associated protein 1 (YAP1), a transcriptional co-activator in the Hippo signaling pathway, mediates PGE 2 function. DLD-1 and SW480 colon cancer cell lines were transfected with vectors expressing transgenes or small hairpin RNAs and incubated with recombinant PGE 2 , with or without pharmacologic inhibitors of signaling proteins, and analyzed by immunoblot, immunofluorescence, quantitative reverse-transcription polymerase chain reaction, transcriptional reporter, and proliferation assays. Dextran sodium sulfate (DSS) was given to induce colitis in C57/BL6 (control) mice, as well as in mice with disruption of the hydroxyprostaglandin dehydrogenase 15 gene (15-PGDH-knockout mice), Yap1 gene (YAP-knockout mice), and double-knockout mice. Some mice also were given indomethacin to block PGE 2 synthesis. 15-PGDH knockout mice were crossed with mice with intestine-specific disruption of the salvador family WW domain containing 1 gene (Sav1), which encodes an activator of Hippo signaling. We performed immunohistochemical analyses of colon biopsy samples from 26 patients with colitis-associated cancer and 51 age-and sex-matched patients with colorectal cancer (without colitis). Incubation of colon cancer cell lines with PGE 2 led to phosphorylation of cyclic adenosine monophosphate-responsive element binding protein 1 and increased levels of YAP1 messenger RNA, protein, and YAP1 transcriptional activity. This led to increased transcription of the prostaglandin-endoperoxide synthase 2 gene (PTGS2 or cyclooxygenase 2) and prostaglandin E-receptor 4 gene (PTGER4 or EP4). Incubation with PGE 2 promoted proliferation of colon cancer cell lines, but not cells with knockdown of YAP1. Control mice

49 CFR 37.33 - Airport transportation systems.

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Airport transportation systems. 37.33 Section 37.33 Transportation Office of the Secretary of Transportation TRANSPORTATION SERVICES FOR INDIVIDUALS WITH DISABILITIES (ADA) Applicability § 37.33 Airport transportation systems. (a) Transportation...

Preliminary assessment of the imaging capability of the YAP-(S)PET small animal scanner in neuroscience

Energy Technology Data Exchange (ETDEWEB)

Bartoli, Antonietta [Department of Physics ' E. Fermi' and Center of Excellence ' AmbiSEN' , University of Pisa, and INFN, Sezione di Pisa, Pisa I- 56127 (Italy)]. E-mail: bartoli@df.unipi.it; Belcari, Nicola [Department of Physics ' E. Fermi' and Center of Excellence ' AmbiSEN' , University of Pisa, and INFN, Sezione di Pisa, Pisa I- 56127 (Italy); Stark, Daniela [Institute of Nuclear Chemistry, University of Mainz, Mainz D-55099 (Germany); Hoehnemann, Sabine [Institute of Nuclear Chemistry, University of Mainz, Mainz D-55099 (Germany); Piel, Markus [Institute of Nuclear Chemistry, University of Mainz, Mainz D-55099 (Germany); Jennewein, Marc [Institute of Nuclear Chemistry, University of Mainz, Mainz D-55099 (Germany); Schmitt, Ulrich [Department of Psychiatry, University of Mainz, Mainz D-55099 (Germany); Tillmanns, Julia [Institute of Physiology and Pathophysiology, University of Mainz, Mainz D-55099 (Germany); Thews, Oliver [Institute of Physiology and Pathophysiology, University of Mainz, Mainz D-55099 (Germany); Hiemke, Christoph [Department of Psychiatry, University of Mainz, Mainz D-55099 (Germany); Roesch, Frank [Institute of Nuclear Chemistry, University of Mainz, Mainz D-55099 (Germany); Del Guerra, Alberto [Department of Physics ' E. Fermi' and Center of Excellence ' AmbiSEN' , University of Pisa, and INFN, Sezione di Pisa, Pisa I- 56127 (Italy)

2006-12-20

The new and fully engineered version of the YAP-(S)PET small animal scanner has been tested at the University of Mainz for preliminary assessment of its imaging capability for studies related to neuropharmacology and psychiatry. The main feature of the scanner is the capability to combine PET and SPECT techniques. It allows the development of new and interesting protocols for the investigation of many biological phenomena, more effectively than with PET or SPECT modalities alone. The scanner is made up of four detector heads, each one composed of a 4x4 cm{sup 2} of YAlO{sub 3}:Ce (or YAP:Ce) matrix, and has a field of view (FOV) of 4 cm axiallyx4 cm o transaxially. In PET mode, the volume resolution is less than 8 mm{sup 3} and is nearly constant over the whole FOV, while the sensitivity is about 2%. The SPECT performance is not so good, due to the presence of the multi-hole lead collimator in front of each head. Nevertheless, the YAP-PET scanner offers excellent resolution and sensitivity for performing on the availability of D2-like dopamine receptors on mice and rats in both PET and SPECT modalities.

Imaging properties of cerium doped Yttrium Aluminum Oxide (YAP:Ce) powder scintillating screens under X-ray excitation

Energy Technology Data Exchange (ETDEWEB)

Kalivas, N. [Greek Atomic Energy Commission, 15310 Ag. Paraskevi, P.O. Box 60092 (Greece); Valais, I. [Department of Medical Physics, Medical School, University of Patras, 26500 Patras (Greece)]|[Department of Medical Instruments Technology, Technological Educational Institution of Athens, Ag. Spyridonos Street, Aigaleo, 12210 Athens (Greece); Salemis, G.; Karagiannis, C.; Konstantinidis, A.; Nikolopoulos, D. [Department of Medical Instruments Technology, Technological Educational Institution of Athens, Ag. Spyridonos Street, Aigaleo, 12210 Athens (Greece); Loudos, G.; Sakelios, N.; Karakatsanis, N.; Nikita, K. [Department of Electrical and Computer Engineering, National Technical University of Athens, 9 Iroon Polytechniou, 15780 Zografos (Greece); Gayshan, V.L.; Gektin, A.V. [Institute of Scintillation Materials, Lenin Avenue 60, 310072 Kharkov (Ukraine); Sianoudis, I. [Department of Physics, Chemistry and Materials Technology, Technological Educational Institution of Athens, Aigaleo, 12210 Athens (Greece); Giokaris, N. [Physics Department National Capodistrian University of Athens, Panepistimioupolis Ilisia, 15771 Athens (Greece)]|[Institute of Accelerating Systems and Applications, P.O. Box 17214, 10024 Athens (Greece); Nomicos, C.D. [Department of Electronics, Technological Educational Institution of Athens, Aigaleo, 12210 Athens (Greece); Dimitropoulos, N. [Department of Medical Imaging, ' Euromedica' Medical Center, Mesogeion 2-4, 11527 Athens (Greece); Cavouras, D. [Department of Medical Instruments Technology, Technological Educational Institution of Athens, Ag. Spyridonos Street, Aigaleo, 12210 Athens (Greece); Panayiotakis, G. [Department of Medical Physics, Medical School, University of Patras, 26500 Patras (Greece); Kandarakis, I. [Department of Medical Instruments Technology, Technological Educational Institution of Athens, Ag. Spyridonos Street, Aigaleo, 12210 Athens (Greece)]. E-mail: kandarakis@teiath.gr

2006-12-20

The aim of the present study was to evaluate the imaging performance of YAP:Ce powder scintillating screens under exposure conditions employed in diagnostic radiology (50-140 kV). Various screens were prepared in our laboratory from YAP: Ce powder (Phosphor Technology, Ltd.), with coating thickness ranging from 53 to 110 mg/cm{sup 2}. The imaging performance of the screens was assessed by experimental determination of the modulation transfer function (MTF) and the noise transfer function (NTF). MTF was determined by the edge spread function (ESF) method while NTF was estimated by noise power spectrum (NPS) measurements after uniform screen irradiation. In addition, parameters related to overall image quality, such as the signal-to-noise ratio transfer (MTF/NTF), were estimated. MTF curves were affected by the beam hardening effects caused by the patient simulating 20 mm thick aluminum phantom. Under these conditions MTF values were found to increase with the mean X-ray photon energy. A similar effect was observed for NTF curves. Results were compared with data obtained on CsI:Tl scintillator. Taking into consideration the very fast response of YAP:Ce, these data may be of interest in designing X-ray imaging detectors.

Yeager Airport Hydrogen Vehicle Test Project

Energy Technology Data Exchange (ETDEWEB)

Davis, Williams [West Virginia University Research Corporation, Morgantown, WV (United States)

2015-10-01

The scope of this project was changed during the course of the project. Phase I of the project was designed to have the National Alternative Fuels Training Consortium (NAFTC), together with its partners, manage the Hydrogen Vehicle Test Project at the Yeager Airport in conjunction with the Central West Virginia Regional Airport Authority (CWVRAA) in coordination with the United States Department of Energy National Energy Technology Laboratory (U.S. DOE NETL). This program would allow testing and evaluation of the use of hydrogen vehicles in the state of West Virginia utilizing the hydrogen fueling station at Yeager Airport. The NAFTC and CWVRAA to raise awareness and foster a greater understanding of hydrogen fuel and hydrogen-powered vehicles through a targeted utilization and outreach and education effort. After initial implementation of the project, the project added, determine the source(s) of supply for hydrogen powered vehicles that could be used for the testing. After completion of this, testing was begun at Yeager Airport. During the course of the project, the station at Yeager Airport was closed and moved to Morgantown and the West Virginia University Research Corporation. The vehicles were then moved to Morgantown and a vehicle owned by the CWVRAA was purchased to complete the project at the new location. Because of a number of issues detailed in the report for DE-FE0002994 and in this report, this project did not get to evaluate the effectiveness of the vehicles as planned.

Ant Colony Algorithm and Simulation for Robust Airport Gate Assignment

Directory of Open Access Journals (Sweden)

Hui Zhao

2014-01-01

Full Text Available Airport gate assignment is core task for airport ground operations. Due to the fact that the departure and arrival time of flights may be influenced by many random factors, the airport gate assignment scheme may encounter gate conflict and many other problems. This paper aims at finding a robust solution for airport gate assignment problem. A mixed integer model is proposed to formulate the problem, and colony algorithm is designed to solve this model. Simulation result shows that, in consideration of robustness, the ability of antidisturbance for airport gate assignment scheme has much improved.

Interference Analysis for an Aeronautical Mobile Airport Communications System

Science.gov (United States)

Wilson, Jeffrey D.; Kerczewski, Robert J.

2011-01-01

The next generation of aeronautical communications for airport surface applications has been identified through a NASA research program and an international collaborative future communications study. The result, endorsed by both the United States and European regulatory agencies is called AeroMACS (Aeronautical Mobile Airport Communications System) and is based upon the IEEE 802.16e mobile wireless standard. Coordinated efforts to develop appropriate aviation standards for the AeroMACS system are now underway within RTCA (United States) and Eurocae (Europe). AeroMACS will be implemented in a recently allocated frequency band, 5091-5150 MHz. As this band is also occupied by fixed satellite service uplinks, AeroMACS must be designed to avoid interference with this incumbent service. The aspects of AeroMACS operation that present potential interference to the fixed satellite service are under analysis in order to enable the definition of standards that assure that such interference will be avoided. The NASA Glenn Research Center has been involved in this analysis, and the first results of modeling and simulation efforts directed at this analysis are the subject of this presentation.

Reduction of Uncertainty Propagation in the Airport Operations Network

Energy Technology Data Exchange (ETDEWEB)

Rodriguez Sanz, A.; Gomez Comendador, F.; Arnaldo Valdes, R.

2016-07-01

Airport operations are a complex system involving multiple elements (ground access, landside, airside and airspace), stakeholders (ANS providers, airlines, airport managers, policy makers and ground handling companies) and interrelated processes. To ensure appropriate and safe operation it is necessary to understand these complex relationships and how the effects of potential incidents, failures and delays (due to unexpected events or capacity constraints) may propagate throughout the different stages of the system. An incident may easily ripple through the network and affect the operation of the airport as a whole, making the entire system vulnerable. A holistic view of the processes that also takes all of the parties (and the connections between them) into account would significantly reduce the risks associated with airport operations, while at the same time improving efficiency. Therefore, this paper proposes a framework to integrate all relevant stakeholders and reduce uncertainty in delay propagation, thereby lowering the cause-effect chain probability of the airport system (which is crucial for the operation and development of air transport). Firstly, we developed a model (map) to identify the functional relationships and interdependencies between the different stakeholders and processes that make up the airport operations network. This will act as a conceptual framework. Secondly, we reviewed and characterised the main causes of delay. Finally, we extended the system map to create a probabilistic graphical model, using a Bayesian Network approach and influence diagrams, in order to predict the propagation of unexpected delays across the airport operations network. This will enable us to learn how potential incidents may spread throughout the network creating unreliable, uncertain system states. Policy makers, regulators and airport managers may use this conceptual framework (and the associated indicators) to understand how delays propagate across the airport

The dynamics of fauna and population of birds in agricultural landscapes on the border of Kazan International Airport

Science.gov (United States)

Bespalov, A. F.; Belyaev, A. N.

2018-01-01

The dynamics of fauna and population of birds from agricultural lands near Kazan International Airport has been studied for one year. A total of 60 bird species have been registered, of which 26 species must be considered as highly dangerous to flying aircraft. With regard to seasonal activity, the nesting period (April - June) is the most hazardous, since it is characterized by maximum species richness and total population density of birds, as well as their high species diversity. Furthermore, a serious danger is posed by the period of postnesting nomadic movements and the onset of migrations (July - September) when the species diversity turns out to be the highest and the total population density begins to decrease. It has been recommended based on the obtained results that the current crops should be replaced by cultivars that will be less attractive to birds. In spring and autumn, certain bird hazing and frightening measures must be taken on a more regular basis.

The Material Politics of Future Airport Cities

DEFF Research Database (Denmark)

Jensen, Ole B.

This paper aims to conceptualize the relationship between materiality, design and the politics of airports. The paper is conceptual and theoretical but will use as its empirical backcloth the ‘Airport City Futures’ (AirCiF) research projects. AirCiF is funded by the Danish Innovation Fund with 10...... understanding of the processing of airport passengers must include a plethora of disciplines. In relation to this there is a need to explore even further into the newer ‘material turn’ literature (Jensen 2016). In particular the connection between actor networks (Latour 2005), vibrant materialities (Bennett...

Research and Analysis on Energy Consumption Features of Civil Airports

Science.gov (United States)

Li, Bo; Zhang, Wen; Wang, Jianping; Xu, Junku; Su, Jixiang

2017-11-01

Civil aviation is an important part of China’s transportation system, and also the fastest-growing field of comprehensive transportation. Airports, as a key infrastructure of the air transportation system, are the junctions of air and ground transportation. Large airports are generally comprehensive transportation hubs that integrate various modes of transportation, serving as important functional zones of cities. Compared with other transportation hubs, airports cover a wide area, with plenty of functional sections, complex systems and strong specialization, while airport buildings represented by terminals have exhibited characteristics of large space, massive energy consumption, high requirement for safety and comfort, as well as concentrated and rapidly changing passenger flows. Through research and analysis on energy consumption features of civil airports, and analysis on energy consumption features of airports with different sizes or in different climate regions, this article has drawn conclusions therefrom.

Systemic Approach to Traffic Evaluation of Mostar Airport

Directory of Open Access Journals (Sweden)

Eldo Raguž

2005-11-01

Full Text Available The attempt of this work is to systematically find solutionsfor Mostar Airport development through technical and technologicalharmonization of traffic processes undertaken in twoseparate organizations - airport and air traffic control and coordinationbetween other traffic branches. The work uses theindicators of traffic flows and tourist trends in the region, andtogether with the mentioned simulations it attempts to evaluatethe traffic potentials in the region by affecting the change in thecurrent negative traffic flows at Mostar Airport.

Mobile Apps: Improve Airports ́ Brand Image and Differentiate Among Competitors

Directory of Open Access Journals (Sweden)

Lázaro Florido-Benítez

2016-07-01

Full Text Available The image airports project via their applications (apps affects -- directly or indirectly--passengers’ satisfaction. Today, airports are competing among each other to attract more airlines and passengers to improve commercial revenues. Airport apps (as mobile marketing tools are offering a wide range of opportunities to both passengers and airports. Apps are the best solution if airports want to improve the passenger experience as well as differentiate themselves from their competitors. The results from this investigation reveal that an airport’s image-perception has either a positive or negative effect on customer satisfaction. Our structural equation model confirms that the projection of the airport image on an app improves passengers’ sense of security-control, along with cross selling. This paper provides a glimpse to how commercial activities in airports will function with interactive media.

Eindhoven Airport : towards zero CO2 emissions

NARCIS (Netherlands)

Jorge Simoes Pedro, Joana

2015-01-01

Eindhoven airport is growing and it is strongly committed to take this opportunity to invest in innovative solutions for a sustainable development. Therefore, this document proposes a strategic plan for reaching Zero CO2 emissions at Eindhoven airport. This document proposes to reduce the CO2

Predicting Taxi-Out Time at Congested Airports with Optimization-Based Support Vector Regression Methods

Directory of Open Access Journals (Sweden)

Guan Lian

2018-01-01

Full Text Available Accurate prediction of taxi-out time is significant precondition for improving the operationality of the departure process at an airport, as well as reducing the long taxi-out time, congestion, and excessive emission of greenhouse gases. Unfortunately, several of the traditional methods of predicting taxi-out time perform unsatisfactorily at congested airports. This paper describes and tests three of those conventional methods which include Generalized Linear Model, Softmax Regression Model, and Artificial Neural Network method and two improved Support Vector Regression (SVR approaches based on swarm intelligence algorithm optimization, which include Particle Swarm Optimization (PSO and Firefly Algorithm. In order to improve the global searching ability of Firefly Algorithm, adaptive step factor and Lévy flight are implemented simultaneously when updating the location function. Six factors are analysed, of which delay is identified as one significant factor in congested airports. Through a series of specific dynamic analyses, a case study of Beijing International Airport (PEK is tested with historical data. The performance measures show that the proposed two SVR approaches, especially the Improved Firefly Algorithm (IFA optimization-based SVR method, not only perform as the best modelling measures and accuracy rate compared with the representative forecast models, but also can achieve a better predictive performance when dealing with abnormal taxi-out time states.

A model for transfer baggage handling at airports

DEFF Research Database (Denmark)

Barth, Torben C.; Timler Holm, Janus; Lindorff Larsen, Jakob

This work deals with the handling of baggage from passengers changing aircraft at an airport. The transfer baggage problem is to assign the bags from each arriving aircraft to an infeed area into the airport infrastructure. The infrastructure will then distribute the bags to the handling faciliti...... is studied and future approaches for improving robustness are discussed. The presented solution approach runs successfully as part of the operation control systems at Frankfurt Airport since 2008.......This work deals with the handling of baggage from passengers changing aircraft at an airport. The transfer baggage problem is to assign the bags from each arriving aircraft to an infeed area into the airport infrastructure. The infrastructure will then distribute the bags to the handling facilities...... and robustness. The model can be solved with a commercial MIP-solver. Furthermore, the use of the model in the dynamic environment during daily operations is introduced. The model includes two different approaches for increasing the robustness of the generated solutions. The uncertainty of the input data...

Autonomous Airport Operations for Safe and Efficient Use of Airports, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — The concepts of Virtual Towers and Autonomous Airport Operations emerged as cost-effective options in early conceptualization of the Next-Generation Air...

Expanding Regional Airport Usage to Accommodate Increased Air Traffic Demand

Science.gov (United States)

Russell, Carl R.

2009-01-01

Small regional airports present an underutilized source of capacity in the national air transportation system. This study sought to determine whether a 50 percent increase in national operations could be achieved by limiting demand growth at large hub airports and instead growing traffic levels at the surrounding regional airports. This demand scenario for future air traffic in the United States was generated and used as input to a 24-hour simulation of the national airspace system. Results of the demand generation process and metrics predicting the simulation results are presented, in addition to the actual simulation results. The demand generation process showed that sufficient runway capacity exists at regional airports to offload a significant portion of traffic from hub airports. Predictive metrics forecast a large reduction of delays at most major airports when demand is shifted. The simulation results then show that offloading hub traffic can significantly reduce nationwide delays.

Progress on the Development of Future Airport Surface Wireless Communications Network

Science.gov (United States)

Kerczewski, Robert J.; Budinger, James M.; Brooks, David E.; Franklin, Morgan; DeHart, Steve; Dimond, Robert P.; Borden, Michael

2009-01-01

Continuing advances in airport surface management and improvements in airport surface safety are required to enable future growth in air traffic throughout the airspace, as airport arrival and departure delays create a major system bottleneck. These airport management and safety advances will be built upon improved communications, navigation, surveillance, and weather sensing, creating an information environment supporting system automation. The efficient movement of the digital data generated from these systems requires an underlying communications network infrastructure to connect data sources with the intended users with the required quality of service. Current airport surface communications consists primarily of buried copper or fiber cable. Safety related communications with mobile airport surface assets occurs over 25 kHz VHF voice and data channels. The available VHF spectrum, already congested in many areas, will be insufficient to support future data traffic requirements. Therefore, a broadband wireless airport surface communications network is considered a requirement for the future airport component of the air transportation system. Progress has been made on defining the technology and frequency spectrum for the airport surface wireless communications network. The development of a test and demonstration facility and the definition of required testing and standards development are now underway. This paper will review the progress and planned future work.

75 FR 39091 - Airport Privatization Pilot Program

Science.gov (United States)

2010-07-07

... Privatization Pilot Program AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Receipt and... application for participation in the airport privatization pilot program received under 49 U.S.C. 47134. The... application to the FAA for exemption under the pilot program. 49 U.S.C. 47134 establishes an airport...

TEAD4-YAP interaction regulates tumoral growth by controlling cell-cycle arrest at the G1 phase

International Nuclear Information System (INIS)

Takeuchi, Shin; Kasamatsu, Atsushi; Yamatoji, Masanobu; Nakashima, Dai; Endo-Sakamoto, Yosuke; Koide, Nao; Takahara, Toshikazu; Shimizu, Toshihiro; Iyoda, Manabu; Ogawara, Katsunori; Shiiba, Masashi; Tanzawa, Hideki; Uzawa, Katsuhiro

2017-01-01

TEA domain transcription factor 4 (TEAD4), which has critical functions in the process of embryonic development, is expressed in various cancers. However, the important role of TEAD4 in human oral squamous cell carcinomas (OSCCs) remain unclear. Here we investigated the TEAD4 expression level and the functional mechanism in OSCC using quantitative reverse transcriptase-polymerase chain reaction, Western blot analysis, and immunohistochemistry. Furthermore, TEAD4 knockdown model was used to evaluate cellular proliferation, cell-cycle analysis, and the interaction between TEAD4 and Yes-associated protein (YAP) which was reported to be a transcription coactivator of cellular proliferation. In the current study, we found that TEAD4 expression increased significantly in vitro and in vivo and correlated with tumoral size in OSCC patients. TEAD4 knockdown OSCC cells showed decreased cellular proliferation resulting from cell-cycle arrest in the G1 phase by down-regulation of cyclins, cyclin-dependent kinases (CDKs), and up-regulation of CDK inhibitors. We also found that the TEAD4-YAP complex in the nuclei may be related closely to transcriptions of G1 arrest-related genes. Taken together, we concluded that TEAD4 might play an important role in tumoral growth and have potential to be a therapeutic target in OSCCs. - Highlights: • TEAD4 contributes to tumor progression in OSCCs. • TEAD4 knockdown results in cell-cycle arrest at the G1phase in OSCC cells. • In TEAD4 knockdown cells, the amount of YAP in the nucleus decreases. • Activation of the TEAD4-YAP complex is an important factor in OSCC tumor growth. • TEAD4 might be a critical biomarker and a therapeutic target for OSCCs.

The first survey of airborne trace elements at airport using moss bag technique.

Science.gov (United States)

Vuković, Gordana; Urošević, Mira Aničić; Škrivanj, Sandra; Vergel, Konstantin; Tomašević, Milica; Popović, Aleksandar

2017-06-01

Air traffic represents an important way of social mobility in the world, and many ongoing discussions are related to the impacts that air transportation has on local air quality. In this study, moss Sphagnum girgensohnii was used for the first time in the assessment of trace element content at the international airport. The moss bags were exposed during the summer of 2013 at four sampling sites at the airport 'Nikola Tesla' (Belgrade, Serbia): runway (two), auxiliary runway and parking lot. According to the relative accumulation factor (RAF) and the limit of quantification of the moss bag technique (LOQ T ), the most abundant elements in the samples were Zn, Na, Cr, V, Cu and Fe. A comparison between the element concentrations at the airport and the corresponding values in different land use classes (urban central, suburban, industrial and green zones) across the city of Belgrade did not point out that the air traffic and associated activities significantly contribute to the trace element air pollution. This study emphasised an easy operational and robust (bio)monitoring, using moss bags as a suitable method for assessment of air quality within various microenvironments with restriction in positioning referent instrumental devices.

Alternative Fuels Data Center: Colorado Airport Relies on Natural Gas

Science.gov (United States)

Fueling Stations Colorado Airport Relies on Natural Gas Fueling Stations to someone by E-mail Share Alternative Fuels Data Center: Colorado Airport Relies on Natural Gas Fueling Stations on Facebook Tweet about Alternative Fuels Data Center: Colorado Airport Relies on Natural Gas Fueling Stations on

The making of the modern airport executive: Causal connections among key attributes in career development, compromise, and satisfaction in airport management

Science.gov (United States)

Byers, David Alan

The purpose of this study was to identify specific career development attributes of contemporary senior-level airport executives and to evaluate the relationship of these attributes to the level of satisfaction airport executives have in their career choice. Attribute sets that were examined included early aviation interests, health factors, psychological factors, demographic factors, formal education, and other aviation-related experiences. A hypothesized causal model that expressed direct and indirect effects among these attributes relative to airport executives' career satisfaction was tested using sample data collected from 708 airport executives from general aviation and commercial service airport throughout the United States. Applying a multiple regression analysis strategy to the model, the overall results revealed that 16% of the variability in airport executives' career satisfaction scores was due to the collective influence of the six research attribute sets, this was significant. The results of the path analysis also indicated that four attribute sets (early aviation interests, health factors, formal education, and other aviation-related experiences) had respective direct significant effects on participants' career satisfaction. Early aviation interests, health factors, and demographic factors had additional indirect effects on career satisfaction; all were mediated by formal education attitude. These results were inconsistent with the hypothesized path model and a revised model was developed to reflect the sample data. The findings suggest that airport executives, as a group, are satisfied with their career choice. Early aviation interests appear to play an important role for influencing the career field selection phase of career development. The study also suggests health factors, formal education, and other aviation-related experiences such as flight training or military experience influence the compromise phase of career development. Each of these

AIRPORT CONCESSIONS IN BRAZIL AND ITS INFLUENCES ON SERVICE QUALITY: THE CASES OF BRASÍLIA AND SÃO PAULO – GUARULHOS AIRPORTS

Directory of Open Access Journals (Sweden)

Thiago Allis

2017-12-01

Full Text Available Over the last decade, the Brazilian air market has tripled in size, a result of economic expansion and the spread of the air travel culture, among others. As far as airport infrastructures are concerned, during the mega-events era (2014 FIFA World Cup and the 2016 Summer Olympics, the airport management sector started to receive greater investments from private and foreign companies. After 2012, a large array of improvements took place, in order to meet the demands associated with the mega-events, but also to tackle the increase of domestic air traffic. In this context, this paper aims to identify, describe and analyze the influences of the airport concession in Brazil on the quality of services perceived by the users (passengers. For that, an analysis of the reports of the aviation authorities is carried out. The airports of Guarulhos (São Paulo and Brasília (Federal District, among the first to be privatized, were selected as case studies. From this study, the mobility of global capital associated with airport management deserves to be highlighted, while the expertise of these large companies is expected to contribute to the increase in the quality of services in Brazilian airports - historically managed by public sector.

76 FR 26183 - Safety Zone; Repair of High Voltage Transmission Lines to Logan International Airport, Saugus...

Science.gov (United States)

2011-05-06

... the repairs. Because of the vital importance of the repairs to Logan Airport, and the safety zone... designated on scene representative may be contacted via VHF Channel 16 or by telephone at (617) 223-5750... relationship between the Federal Government and Indian tribes, or on the distribution of power and...

The Impact of Airport Performance towards Construction and Infrastructure Expansion in Indonesia

Science.gov (United States)

Laksono, T. D.; Kurniasih, N.; Hasyim, C.; Setiawan, M. I.; Ahmar, A. S.

2018-01-01

Development that is generated from airport areas includes construction and infrastructure development. This research reviews about how the implementation of material management in certain construction project and the relationship between development especially construction and infrastructure development with Airport Performance. The method that is used in this research is mixed method. The population in this research is 297 airports that are existed in Indonesia. From those 297 airports then it is chosen airports that have the most completed data about construction project and it is obtained 148 airports. Based on the coefficient correlation (R) test it is known that construction and infrastructure development has relatively strong relation with airport performance variable, but there are still other factors that influence construction and infrastructure development become bigger effect.

Estimating environmental value losses from earth materials excavation and infilling for large-scale airport construction: a case of Dalian Offshore Airport, Dalian, China.

Science.gov (United States)

Yan, Hua-Kun; Wang, Nuo; Wu, Nuan; Song, Nan-Qi; Zhu, Dao-Li

2017-09-01

Large-scale airport construction removes large quantities of earth materials, resulting in serious environmental pollution and ecosystem damage. However, studies of environmental concerns caused by the materials used in airport construction are still preliminary, and those case studies on the impacts of large-scale offshore airport development are very limited. China's Dalian Offshore Airport is considered here to study the environmental value loss from 240 million m 3 of materials excavations and 21 km 2 of artificial island infillings. The findings show that the calculated annual environmental value loss for the development of the Dalian Offshore Airport is approximately US$7.75 million, including US$1.81 million and US$1.47 million of direct economic loss of timber resources and marine biology resources, respectively, and US$1.53 million and US$2.79 million value losses of forest and marine ecosystem services damaged caused by materials excavation and infilling, respectively. The conclusions of this study provide an important foundation to quantitatively analyse the environmental impact of the Dalian Offshore Airport's development and can be used as a reference for similar engineering and environment impact assessment programs.

14 CFR 93.123 - High density traffic airports.

Science.gov (United States)

2010-01-01

... Airport Class of user LaGuardia 4, 5 Newark O'Hare 2, 3, 5 Ronald Reagan National 1 Air carriers 48 40 120... aircraft operations at Ronald Reagan Washington National Airport, the term “commuters” means aircraft...

Airport Economics: Management Control Financial Reporting Systems

Science.gov (United States)

Buchbinder, A.

1972-01-01

The development of management control financial reporting systems for airport operation is discussed. The operation of the system to provide the reports required for determining the specific revenue producing facilities of airports is described. The organization of the cost reporting centers to show the types of information provided by the system is analyzed.

“Non-Aviation” activities and the introduction of new thinking and ideas in the airport business: Empirical evidence from an Italian case study

Directory of Open Access Journals (Sweden)

Vincenzo Fasone

2012-05-01

Full Text Available Purpose: This paper aims to describe the main changes occurring in the airport industry with particular attention to the increasing relevance of the non-aviation activities. In fact, during the most recent decades, the airport business has evolved into a dynamic and competitive industry. In order to reduce their deficits airport management policies have progressively favoured the commercial aspects in order to produce greater profit margins. In many countries, greater management elasticity in business administration has occurred, and important modifications have been introduced in the national and international regulations according to a market oriented perspective.Design/methodology/approach: The method used is the case study approach and the analysis utilizes empirical data originating from the airport in Olbia.Findings: Findings show how the choice to invest in the non-aviation sector can be ascribed to the strategic orientation adopted by airport managers.Originality/value: Empirical evidence can highlight certain trends in the industry, whose values can lead to a core definition of the new paths of development for the airport business to follow in the non-aviation dimension, and identifying at the same time innovative business ideas for opening up new market scenarios.

Tanzania - Mafia Island Airport

Data.gov (United States)

Millennium Challenge Corporation — The evaluation design and subsequent data gathering activities will address the following key research questions: a) Has the Mafia Island Airport Upgrade Project...

The effects of pushback delays on airport ground movement

OpenAIRE

Stergianos, Christofas; Atkin, Jason; Schittekat, Patrick; Nordlander, Tomas Eric; Gerada, C.; Morvan, Herve

2015-01-01

With the constant increase in air traffic, airports are facing capacity problems. Optimisation methods for specific airport processes are starting to be increasingly utilised by many large airports. However, many processes do happen in parallel, and maximising the potential benefits will require a more complex optimisation model, which can consider multiple processes simultaneously and take into account the detailed complexities of the processes where necessary, rather than using more abstrac...

Geology and geochemistry of epithermal precious metal vein systems in the intra-oceanic arcs of Palau and Yap, western Pacific

Science.gov (United States)

Rytuba, J.J.; Miller, W.R.

1990-01-01

The Palau and Yap arcs are part of an intra-oceanic island-arc-trench system which separates the Pacific and Philippine plates in the western Pacific Ocean. The 350-km-long Palau arc consists of over 200 islands while the 400-km-long Yap arc located to the north has only four major islands exposed. Four of the largest islands in Palau are composed primarily of early Eocene to mid-Miocene volcanic rocks and the four islands comprising Yap contain only Miocene volcanic rocks. Basalt and basaltic andesites of the Babelthuap Formation are the oldest volcanic rocks in Palau and are characterized by high MgO, Ni and Cr and low TiO2 and have a boninitic affinity. They form the central and southeastern parts of Babelthuap Island. Oligocene arc tholeiite flows having an age of 34-35.5 Ma comprise most of the three smaller volcanic islands in Palau and the western part of Babelthuap. The youngest volcanic rocks are dacitic intrusions having an age of 22.7-23.2 Ma. The Yap arc is unusual in that metamorphic rocks up to amphibolite grade form most of the islands. These are underlain by a melange composed of igneous and volcanic clasts as well as clasts from a dismembered copper-gold skarn deposit. Miocene volcanic rocks consisting of flows and volcaniclastic deposits overlie the melange and metamorphic complex. An epithermal precious-metal vein system hosted by flows and flow breccias of the Babelthuap Formation occurs in an area 1.5 km by 1 km on the southeast side of Babelthuap Island. Over 50 veins and mineralized breccias ranging up to 2 m in width and having a strike length up to 500 m contain from trace to 13.0 ppm gold. The veins consist of quartz with varying amounts of sulfides and iron oxides after sulfides and the mineralized breccias consist of brecciated country rock cemented by quartz and iron oxides after sulfides. The veins and mineralized breccias generally dip within 15?? of vertical and have two preferred orientations, north-northwest and north

Farklı Durum Çeşitlerinden Mahalli ve Laboratuvar Koşullarında Yapılmış Bulguların Bazı Vitamin ve Mineral İçerikleri

Directory of Open Access Journals (Sweden)

Berrin Özkaya

2015-02-01

Full Text Available Araştırmada 5 farklı durum buğdayının, bunlardan mahalli ve laboratuvar koşullarında yapılan bulguların bazı kimyasal özellikleri ile tiamin, riboflavin ve mineral içerikleri karşılaştırılmıştır. Buğdayların yapımı sırasında buğdayların tiamin, özellikle de riboflavin miktarları azalmıştır. Mahalli koşullarda yapılan bulgurların tiamin ve riboflavin miktarları laboratuvarda yapılanlara kıyasla biraz düşük çıkmıştır. Bulgurların mineral içerikleri (Fe, Cu, Zn, Mn, Ca ve Mg miktarları yapıldıktan buğdaylara kıyasla daha düşük çıkmış, mahalli ve laboratuvar koşullarında yapılan bulgurların mineral madde miktarlarında önemli bir fark görülmemiştir.

Physical environment. [environmental impact statement required for general aviation airport construction

Science.gov (United States)

1975-01-01

Environmental legislation affecting airports and the more common environmental effects resulting from airport construction are discussed with special emphasis on general aviation airports. The discussion is focused on the regulation of noise, pollution, and water quality.

Preliminary assessment report for Virginia Army National Guard Army Aviation Support Facility, Richmond International Airport, Installation 51230, Sandston, Virginia

International Nuclear Information System (INIS)

Dennis, C.B.

1993-09-01

This report presents the results of the preliminary assessment (PA) conducted by Argonne National Laboratory at the Virginia Army National Guard (VaARNG) property in Sandston, Virginia. The Army Aviation Support Facility (AASF) is contiguous with the Richmond International Airport. Preliminary assessments of federal facilities are being conducted to compile the information necessary for completing preremedial activities and to provide a basis for establishing corrective actions in response to releases of hazardous substances. The PA is designed to characterize the site accurately and determine the need for further action by examining site activities, quantities of hazardous substances present, and potential pathways by which contamination could affect public health and the environment. The AASF, originally constructed as an active Air Force interceptor base, provides maintenance support for VaARNG aircraft. Hazardous materials used and stored at the facility include JP-4 jet fuel, diesel fuel, gasoline, liquid propane gas, heating oil, and motor oil

14 CFR 93.345 - VFR outbound procedures for fringe airports.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false VFR outbound procedures for fringe airports... Metropolitan Area Special Flight Rules Area § 93.345 VFR outbound procedures for fringe airports. (a) A pilot may depart from a fringe airport as defined in § 93.335 without filing a flight plan or communicating...

Research on Recycling and Utilization of Solid Waste in Civil Airport

Science.gov (United States)

Li, Bo; Zhang, Wen; Wang, Jianping; Yi, Wei

2018-05-01

The aviation industry is embracing unprecedented prosperity together with the economic development. Building green airports resource-saving, environment-friendly and sustainable has become the inevitability of the times. The operation of airport will generate the large amount of waste every day, which certainly exposes airports and surrounding regions to waste disposal and ecological environment pressure. Waste disposal directly affects the surrounding environment of airports, which can be effectively mitigated by disposing waste into resources, i.e., sorting and recycling them into renewable materials. The development of green airport can also be promoted in this process. The article elaborates on the current methods of waste disposal adopted by airports. According to the principle of waste reduction, harmlessness, and resource recycling, a set of solid waste recycling and utilization methods suitable for airports are proposed, which can reduce the costs of waste transported to other places and landfilled. Various environmental pollution caused by landfill and other disposal methods can also be contained effectively. At the same time, resources can be fully recycled, converting waste into useful resources in an efficient and environmental-friendly way.

Aerotropolis, the airport of the future; Aerotropolis - Der Grossflughafen der Zukunft

Energy Technology Data Exchange (ETDEWEB)

Bender, W [Fraport AG, Frankfurt am Main (Germany)

2003-12-01

'Aerotropolis' is a term coined by US scientists and futurologists to describe large airports of the future. Airport cities will combine many different functions: Economic, job-creating, interesting sites for new businesses, real estate in top situations, business networks, providing a positive image for cities and regions, providing better infrastructure without state funding, etc. The Frankfurt airport city is described as an example. Frankfurt is Europe's second biggest passenger airport after London and the biggest European freight airport. (orig.) [German] Von 'Aerotropolis' sprechen amerikanische Wissenschaftler und Zukunftsforscher bei der Beschreibung von Grossflughaefen von morgen. Zukunftsstaedte entstehen durch Drehkreuze der Mobilitaet mit optimaler Intermodalitaet und hervorragenden Strukturen fuer elektronische Vernetzung. So sind die Airport-Cities heute wirtschaftliche Leuchttuerme, Jobmotoren, Anziehungspunkte fuer Industrieansiedlungen, Eins-A-Lage fuer Immobilien, Netzwerke fuer Business-Verbindungen und gleichzeitig positive Imagetraeger fuer Kommunen und Regionen, verbessern Wirtschaftsstrukturen, ohne die Hand fuer staatliche Subventionen aufzuhalten. Ein Beispiel fuer eine solche Airport-City ist Frankfurt, der nach London bei den Passagieren zweitgroesster europaeischer Flughafen, bei der Fracht sogar Spitzenreiter des Kontinents ist. (orig.)

Werkgelegenheidsmonitor Lelystad Airport

NARCIS (Netherlands)

Zuidberg, J.; Burghouwt, G.; de Wit, J.

2010-01-01

In 2005 kwam BCI tot de conclusie dat onder bepaalde condities 800 arbeidsplaatsen per miljoen passagiers op Lelystad Airport mogen worden verwacht. In een second opinion in opdracht van de Gemeente Lelystad bevestigde SEO (2006) de aannemelijkheid van dit aantal. Naarmate het groot commercieel

Implementing Solar Technologies at Airports

Energy Technology Data Exchange (ETDEWEB)

Kandt, A.; Romero, R.

2014-07-01

Federal agencies, such as the Department of Defense and Department of Homeland Security, as well as numerous private entities are actively pursuing the installation of solar technologies to help reduce fossil fuel energy use and associated emissions, meet sustainability goals, and create more robust or reliable operations. One potential approach identified for siting solar technologies is the installation of solar energy technologies at airports and airfields, which present a significant opportunity for hosting solar technologies due to large amounts of open land. This report focuses largely on the Federal Aviation Administration's (FAA's) policies toward siting solar technologies at airports.

PM EMISSIONS PRODUCED BY AIRCRAFT UNDER THE OPERATIONS AT THE AIRPORT

Directory of Open Access Journals (Sweden)

Oleksandr Zaporozhets

2016-12-01

Full Text Available Purpose: The effects of aircraft engine emissions within the planetary boundary layer under the landing/ take-off operations contribute sufficiently to deterioration of air pollution in the vicinity of the airports and nearby residential areas. Currently the primary object of airport air quality are the nitrogen oxides and particle matter (PM10, PM2.5 and ultrafine PM emissions from aircraft engine exhausts as initiators of photochemical smog and regional haze, which may further impact on human health. Analysis of PM emission inventory results at major European airports highlighted on sufficiently high contribution of aircraft engines and APU. The paper aims to summarize the knowledge on particle size distributions, particle effective density, morphology and internal structure of aircraft PM, these properties are critical for understanding of the fate and potential health impact of PM. It also aims to describe the basic methods for calculation of emission and dispersion of PM, produced by aircrafts under the LTO operations. Methods: analytical solution of the atmospheric diffusion equation is used to calculate the maximum PM concentration from point emission source. The PM concentration varies inversely proportional to the wind velocity u1 and directly proportional to the vertical component of the turbulent exchange coefficient k1/u1. The evaluation of non-volatile PM concentration includes the size and shape of PM. PolEmiCa calculates the distributions of PM fractions for aircraft and APU exhausts (height of installation was given H=4,5m like for Tupolev-154. Results: The maximum concentration of PM in exhaust from APU is higher and appropriate distance is less than in case for gas. PM polydispersity leads to the separation of maximums concentration in space for individual fractions on the wind direction and therefore it contributes to the reduction of maximum total concentration. Discussion:But although the APU has contributed significantly to

Accident caused by Centruroides testaceus (DeGeer, 1778 (Scorpiones, Buthidae, native to the Caribbean, in Brazilian airport

Directory of Open Access Journals (Sweden)

Ricardo Antônio Lobo

2011-12-01

Full Text Available Describes the case of a 6-year-old girl who was stung by a Centruroides testaceus, a scorpion native to the Lesser Antilles, in the Guarulhos International Airport, São Paulo, Brazil, as she disembarked from a flight coming from the Caribbean. The patient presented only local symptoms (a small area of erythema and pain at the sting site, which were resolved after a few hours with analgesics, without the need for antivenom. Physicians who treat patients stung by scorpions should be alert to the possibility of such accidents being caused by non native species, especially those cases that occur near airports or ports.

Air freight in the Stockholm region with focus on Eskilstuna Airport

Directory of Open Access Journals (Sweden)

Kjell-Åke Allan Brorsson

2016-02-01

Full Text Available Purpose: The purpose of this article is to analyse the conditions for commencing air freight operations at the regional Eskilstuna Airport in Sweden, which require investments in airport infrastructure of at least SEK 140 –180 million. Design/ methodology: The qualitative data collection for the study was carried out through open-ended interviews with representatives of airport management, staff, representatives of residents, and actors and stakeholders in the field. In addition, much written material was collected from different authorities. Document analysis was used to systematically evaluate and review the collected documents. Content analysis was applied to organize collected data into categories. Based on the reports, decisions, environmental scanning and interviews, the data have been coded and categorized in tables via thematic analysis. Findings: The major findings of the study are that Eskilstuna Airport lacks cargo facilities and has limited apron space, and that there is strong competition from four other airports in the Stockholm region. The prospects for permanent air freight operations at Eskilstuna Airport are therefore not favourable in the current situation. However, if the development of Eskilstuna Logistics Park and the concept of inter modal highway-rail transportation are successful, they could serve as a major driving force for the development of air cargo. Furthermore, with sustainable development as a guiding principle, there is great potential to develop an airport with a high standard of environmental profile. Originality/ value: My findings are of great value to managers of airports and cargo airlines, as they highlight some of the competition aspects associated with engaging in air cargo at regional airports. The study fills a gap in existing research whose main focus is environmental issues concerning airports in general.

Evaluation of model-predicted hazardous air pollutants (HAPs) near a mid-sized U.S. airport

Science.gov (United States)

Vennam, Lakshmi Pradeepa; Vizuete, William; Arunachalam, Saravanan

2015-10-01

Accurate modeling of aircraft-emitted pollutants in the vicinity of airports is essential to study the impact on local air quality and to answer policy and health-impact related issues. To quantify air quality impacts of airport-related hazardous air pollutants (HAPs), we carried out a fine-scale (4 × 4 km horizontal resolution) Community Multiscale Air Quality model (CMAQ) model simulation at the T.F. Green airport in Providence (PVD), Rhode Island. We considered temporally and spatially resolved aircraft emissions from the new Aviation Environmental Design Tool (AEDT). These model predictions were then evaluated with observations from a field campaign focused on assessing HAPs near the PVD airport. The annual normalized mean error (NME) was in the range of 36-70% normalized mean error for all HAPs except for acrolein (>70%). The addition of highly resolved aircraft emissions showed only marginally incremental improvements in performance (1-2% decrease in NME) of some HAPs (formaldehyde, xylene). When compared to a coarser 36 × 36 km grid resolution, the 4 × 4 km grid resolution did improve performance by up to 5-20% NME for formaldehyde and acetaldehyde. The change in power setting (from traditional International Civil Aviation Organization (ICAO) 7% to observation studies based 4%) doubled the aircraft idling emissions of HAPs, but led to only a 2% decrease in NME. Overall modeled aircraft-attributable contributions are in the range of 0.5-28% near a mid-sized airport grid-cell with maximum impacts seen only within 4-16 km from the airport grid-cell. Comparison of CMAQ predictions with HAP estimates from EPA's National Air Toxics Assessment (NATA) did show similar annual mean concentrations and equally poor performance. Current estimates of HAPs for PVD are a challenge for modeling systems and refinements in our ability to simulate aircraft emissions have made only incremental improvements. Even with unrealistic increases in HAPs aviation emissions the model

78 FR 3311 - Safety Enhancements, Certification of Airports

Science.gov (United States)

2013-01-16

...-airport employees such as Fixed-Base Operators (FBO) or airline mechanics.\\2\\ The FAA intended to propose.... The existing level of training indicates that as a group certificated airports are willing to conduct...) What constitutes acceptable friction levels; (iv) What is an acceptable testing frequency; (v) Are...

Public Use Airports, Geographic WGS84, BTS (2006) [public_use_airports_BTS_2006

Data.gov (United States)

Louisiana Geographic Information Center — The Public Use Airports database is a geographic point database of aircraft landing facilities in the United States and U.S. Territories. Attribute data is provided...

76 FR 82347 - Public Notice for Release of Aeronautical Property at Erie International Airport (ERI), Erie, PA

Science.gov (United States)

2011-12-30

... stormwater management facilities. As such, a drainage easement will be required for PennDOT to maintain... airport to tie into Asbury Road. Parcel 5 is also temporarily impacted while Stormwater Management... constructed outside the limits of the pavement of the widened Asbury Road. This easement will [[Page 82348...

Study Results on Knowledge Requirements for Entry-Level Airport Operations and Management Personnel

Science.gov (United States)

Quilty, Stephen M.

2005-01-01

This paper identifies important topical knowledge areas required of individuals employed in airport operations and management positions. A total of 116 airport managers and airfield operations personnel responded to a survey that sought to identify the importance of various subject matter for entry level airport operations personnel. The results from this study add to the body of research on aviation management curriculum development and can be used to better develop university curriculum and supplemental training focused on airport management and operations. Recommendations are made for specialized airport courses within aviation management programs. Further, this study identifies for job seekers or individuals employed in entry level positions those knowledge requirements deemed important by airport managers and operations personnel at different sized airports.

C-Band Airport Surface Communications System Standards Development, Phase I

Science.gov (United States)

Hall, Edward; Isaacs, James; Zelkin, Natalie; Henriksen. Steve

2010-01-01

This document is being provided as part of ITT's NASA Glenn Research Center Aerospace Communication Systems Technical Support (ACSTS) contract NNC05CA85C, Task 7: "New ATM Requirements--Future Communications, C-Band and L-Band Communications Standard Development." The proposed future C-band (5091- to 5150-MHz) airport surface communication system, referred to as the Aeronautical Mobile Airport Communications System (AeroMACS), is anticipated to increase overall air-to-ground data communications systems capacity by using a new spectrum (i.e., not very high frequency (VHF)). Although some critical services could be supported, AeroMACS will also target noncritical services, such as weather advisory and aeronautical information services as part of an airborne System Wide Information Management (SWIM) program. AeroMACS is to be designed and implemented in a manner that will not disrupt other services operating in the C-band. This report defines the AeroMACS concepts of use, high-level system requirements, and architecture; the performance of supporting system analyses; the development of AeroMACS test and demonstration plans; and the establishment of an operational AeroMACS capability in support of C-band aeronautical data communications standards to be advanced in both international (International Civil Aviation Organization, ICAO) and national (RTCA) forums. This includes the development of system parameter profile recommendations for AeroMACS based on existing Institute of Electrical and Electronics Engineering (IEEE) 802.16e- 2009 standards

Designing Public Space for Mobility: Contestation, Negotiation and Experiment at Amsterdam Airport Schiphol

DEFF Research Database (Denmark)

Nikolaeva, Anna

2012-01-01

The paper investigates airport design, using the example of Amsterdam Airport Schiphol, from the point of view of managers, architects and designers. It is argued that existing accounts of the airport as a space of transit as well as a place for shopping and entertainment have underrated the comp......The paper investigates airport design, using the example of Amsterdam Airport Schiphol, from the point of view of managers, architects and designers. It is argued that existing accounts of the airport as a space of transit as well as a place for shopping and entertainment have underrated...

Numerical simulations of an advection fog event over Shanghai Pudong International Airport with the WRF model

Science.gov (United States)

Lin, Caiyan; Zhang, Zhongfeng; Pu, Zhaoxia; Wang, Fengyun

2017-10-01

A series of numerical simulations is conducted to understand the formation, evolution, and dissipation of an advection fog event over Shanghai Pudong International Airport (ZSPD) with the Weather Research and Forecasting (WRF) model. Using the current operational settings at the Meteorological Center of East China Air Traffic Management Bureau, the WRF model successfully predicts the fog event at ZSPD. Additional numerical experiments are performed to examine the physical processes associated with the fog event. The results indicate that prediction of this particular fog event is sensitive to microphysical schemes for the time of fog dissipation but not for the time of fog onset. The simulated timing of the arrival and dissipation of the fog, as well as the cloud distribution, is substantially sensitive to the planetary boundary layer and radiation (both longwave and shortwave) processes. Moreover, varying forecast lead times also produces different simulation results for the fog event regarding its onset and duration, suggesting a trade-off between more accurate initial conditions and a proper forecast lead time that allows model physical processes to spin up adequately during the fog simulation. The overall outcomes from this study imply that the complexity of physical processes and their interactions within the WRF model during fog evolution and dissipation is a key area of future research.

Airport Status Web Service

Data.gov (United States)

Department of Transportation — A web service that allows end-users the ability to query the current known delays in the National Airspace System as well as the current weather from NOAA by airport...

Alternative Fuels Data Center: St. Louis Airport Relies on Biodiesel and

Science.gov (United States)

Natural Gas Vehicles St. Louis Airport Relies on Biodiesel and Natural Gas Vehicles to someone by E-mail Share Alternative Fuels Data Center: St. Louis Airport Relies on Biodiesel and Natural Gas Vehicles on Facebook Tweet about Alternative Fuels Data Center: St. Louis Airport Relies on Biodiesel and

77 FR 54945 - Notice of Intent To Rule on Change in Use of Aeronautical Property at Louisville International...

Science.gov (United States)

2012-09-06

... Use of Aeronautical Property at Louisville International Airport, Louisville, KY AGENCY: Federal... portion of airport property from aeronautical to non- aeronautical use at the Louisville International.... This action is taken under the provisions of Section 125 of the Wendell H. Ford Aviation Investment...

75 FR 68024 - Notice of Intent To Rule on Change in Use of Aeronautical Property at Louisville International...

Science.gov (United States)

2010-11-04

... Use of Aeronautical Property at Louisville International Airport, Louisville, KY AGENCY: Federal... portion of airport property from aeronautical to non- aeronautical use at the Louisville International.... This action is taken under the provisions of Section 125 of the Wendell H. Ford Aviation Investment...

Airports offer unrealized potential for alternative energy production.

Science.gov (United States)

DeVault, Travis L; Belant, Jerrold L; Blackwell, Bradley F; Martin, James A; Schmidt, Jason A; Wes Burger, L; Patterson, James W

2012-03-01

Scaling up for alternative energy such as solar, wind, and biofuel raises a number of environmental issues, notably changes in land use and adverse effects on wildlife. Airports offer one of the few land uses where reductions in wildlife abundance and habitat quality are necessary and socially acceptable, due to risk of wildlife collisions with aircraft. There are several uncertainties and limitations to establishing alternative energy production at airports, such as ensuring these facilities do not create wildlife attractants or other hazards. However, with careful planning, locating alternative energy projects at airports could help mitigate many of the challenges currently facing policy makers, developers, and conservationists.

78 FR 64048 - Noise Exposure Map Notice for Bob Hope Airport, Burbank, California

Science.gov (United States)

2013-10-25

... Hope Airport, Burbank, California AGENCY: Federal Aviation Administration, (FAA), DOT. ACTION: Notice...-Pasadena Airport Authority, for Bob Hope Airport under the provisions of 49 U.S.C. 47501 et. seq (Aviation... announces that the FAA finds that the noise exposure maps submitted for Bob Hope Airport are in compliance...

Kefir Kültürünün Beyaz Peynir Yapımında Kullanılması Üzerine bir Araştırma

Directory of Open Access Journals (Sweden)

Hasan Yaygın

2015-02-01

Full Text Available Beyaz peynir yapımında kullanılacak saf kültürde yer alması gereken mikroorganizmaları saptamak amacı ile bazı çalışmalar yapılmıştır. Araştırıcıların çoğunluğu saf kültürde S. lactis, S. cremoris ve L. casei’ nin bulunması gerektiğini belirtmişlerdir. Bu çalışmada beyaz peynir yapımında saf kültür olarak kefir kültürü kullanılmıştır. Kefir kültüründe söz konusu bakterilerle beraber bazı maya ve bakteriler de bulunmaktadır. Araştırma sonuçları kefir kültürü katılan sütten yapılan beyaz peynirde asitlik gelişiminin istenilen düzeyde olduğu; tat ve aroma ile yapının tüketiciler tarafından beğenildiğini ortaya çıkarmıştır.

Denizli İlinde İhracatı Yapılan Mantarlar

Directory of Open Access Journals (Sweden)

Kutret GEZER

2016-01-01

Full Text Available Mantarlar protein, karbonhidrat, vitamin ve mineral gibi besinler yönünden zengin içeriğe sahip olmalarının yanı sıra farklı lezzetleriyle, yüzyıllardır insanoğlu için iyi bir besin kaynağı olmuştur. Ayrıca içerdikleri pek çok aktif bileşenin teröpatik etkilerinin bulunması besinsel değerlerini de arttırmaktadır. Ancak taze mantarların raf ömrünün kısa olması, kolay bozulmaları ve her dönemde bulunamamaları gibi bazı olumsuzluklar mantarların gıda sektöründe kullanım alanlarını sınırlamaktadır. Taze tüketime alternatif yöntemlerden biri olan kurutulmuş mantarların kullanımı dünya genelinde giderek yaygınlaşmaktadır. Mantarlar kurutulduğunda tat ve diğer özelliklerini büyük oranda korumaktadırlar. Kurutulmuş mantarlar, öğütülerek toz halinde veya bütün olarak doğrudan tüketilebildiği gibi tatlı, baharat, garnitür, mama, pizza ve çorbalara katılarak çeşitli şekillerde de tüketilebilmektedir. Ülkemizde 2007 yılında 21 ton kurutulmuş mantar ihracatı gerçekleşmiş ve 1.71 milyon dolar ülke ekonomisine katkı sağlanmıştır. Denizli ili kuru veya şoklanmış mantar ihracatında önemli bir yere sahiptir. Bu çalışmada Denizli ilinde kurutularak ihracatı yapılan Boletus edulis, Morchella esculenta, Cantharellus cibarius ve Craterellus cornucopioides türlerinin genel özellikleri ve besin içerikleriyle ilgili bilgilerin verilmesi amaçlanmıştır. Araştırma için konuyla ilgili son zamanlarda yapılmış çalışmalara ulaşılarak yazın taraması yapılmıştır. Bu çalışmaya konu olan mantar türleriyle ilgili bulgular arasındaki ilişkiler göz önüne alınarak, elde edilen veriler bir araya getirilmiş ve yorumlanmıştır.

76 FR 37874 - Notice of Intent To Rule on Request To Release Airport Property at Lehigh Valley International...

Science.gov (United States)

2011-06-28

... land, under agricultural production, and is maintained to protect airspace surfaces of 14 CFR 77.19... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Notice of Intent To Rule on Request... Aviation Administration (FAA), DOT. ACTION: Notice of request to release airport property. SUMMARY: The...

SOME QUESTIONS OF THE GRID AND NEURAL NETWORK MODELING OF AIRPORT AVIATION SECURITY CONTROL TASKS

Directory of Open Access Journals (Sweden)

N. Elisov Lev

2017-01-01

Full Text Available The authors’ original problem-solution-approach concerning aviation security management in civil aviation apply- ing parallel calculation processes method and the usage of neural computers is considered in this work. The statement of secure environment modeling problems for grid models and with the use of neural networks is presented. The research sub- ject area of this article is airport activity in the field of civil aviation, considered in the context of aviation security, defined as the state of aviation security against unlawful interference with the aviation field. The key issue in this subject area is aviation safety provision at an acceptable level. In this case, airport security level management becomes one of the main objectives of aviation security. Aviation security management is organizational-regulation in modern systems that can no longer correspond to changing requirements, increasingly getting complex and determined by external and internal envi- ronment factors, associated with a set of potential threats to airport activity. Optimal control requires the most accurate identification of management parameters and their quantitative assessment. The authors examine the possibility of applica- tion of mathematical methods for the modeling of security management processes and procedures in their latest works. Par- allel computing methods and network neurocomputing for modeling of airport security control processes are examined in this work. It is shown that the methods’ practical application of the methods is possible along with the decision support system, where the decision maker plays the leading role.

Ethnic and Cultural Focus in Airport Driver Training

Science.gov (United States)

Cokley, John; Rankin, William

2009-01-01

A series of linked relationships is advanced which together suggest changes should be made to training programs for airside drivers at major airports in the United States, Australia and the United Kingdom. Overall, the links suggest a relationship between the number of airside incidents such as collisions at airports, the ethnic diversity evident…

14 CFR 93.29 - International Arrival Authorizations.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false International Arrival Authorizations. 93.29... at Chicago O'Hare International Airport § 93.29 International Arrival Authorizations. (a) Except as... marketing arrangement unless the flight was predominately marketed, by contract, under the control of...

41 CFR 102-37.520 - What is the authority for public airport donations?

Science.gov (United States)

2010-07-01

... for public airport donations? 102-37.520 Section 102-37.520 Public Contracts and Property Management... 37-DONATION OF SURPLUS PERSONAL PROPERTY Donations to Public Airports § 102-37.520 What is the authority for public airport donations? The authority for public airport donations is 49 U.S.C. 47151. 49 U...

Take control of your 802.11n airport network

CERN Document Server

Fleishman, Glenn

2009-01-01

Make your 802.11n-based AirPort network fast, reliable, and secure! Find real-world advice from Wi-Fi wizard Glenn Fleishman on setting up the 802.11n models of Apple's AirPort Express, AirPort Extreme, and Time Capsule, with full information about the simultaneous dual-band models introduced in early 2009. You'll get help with all the special networking details, such as how to set the best band and channel for your network, use pre-802.11n base stations and clients without hurting performance, set up complex Int

Louisiana Airport System Plan Five-Year Capital Improvement Program.

Science.gov (United States)

1992-07-01

The Louisiana Airport System Plan (LASP) Five-Year-Capital Improvement Program (CIP) is a development plan for all commercial service, reliever, and general aviation airports in Louisiana. It is a detailed listing of potential projects based on the a...

Tekstilde Yeni Bir Konsept Olan Dendrimerlerin Tarihçesi, Sınıflandırılması, Molekül Yapısı ve Özellikleri

Directory of Open Access Journals (Sweden)

Osman NAMIRTI

2011-02-01

Full Text Available Son 20 yıldır polimer kimyası tarafından çok sayıda lineer olmayan yapılar ortaya çıkartılmış ve polimer sentezi sırasında çok sayıda yan dalların eklenmesi, çok sayıda uç gruplara sahip makromoleküllerin eldesine yol açmıştır. Bu polimerlerin iki tipi, düzgün yapıda dallanmış "dendrimer"ler ile dallanmanın rastgele oluştuğu "hiperdallanmış moleküller"dir. Bu makalede özel yapıları nedeniyle tekstilde de çeşitli uygulama alanları bulan dendrimerlerin tarihçesi, sınıflandırılması, molekül yapısı ve özellikleri hakkında bilgi verilmektedir.

An Algorithm for Managing Aircraft Movement on an Airport Surface

Directory of Open Access Journals (Sweden)

Giuseppe Maresca

2013-08-01

Full Text Available The present paper focuses on the development of an algorithm for safely and optimally managing the routing of aircraft on an airport surface in future airport operations. This tool is intended to support air traffic controllers’ decision-making in selecting the paths of all aircraft and the engine startup approval time for departing ones. Optimal routes are sought for minimizing the time both arriving and departing aircraft spend on an airport surface with engines on, with benefits in terms of safety, efficiency and costs. The proposed algorithm first computes a standalone, shortest path solution from runway to apron or vice versa, depending on the aircraft being inbound or outbound, respectively. For taking into account the constraints due to other traffic on an airport surface, this solution is amended by a conflict detection and resolution task that attempts to reduce and possibly nullify the number of conflicts generated in the first phase. An example application on a simple Italian airport exemplifies how the algorithm can be applied to true-world applications. Emphasis is given on how to model an airport surface as a weighted and directed graph with non-negative weights, as required for the input to the algorithm.

EVALUATION OF SCENARIOS OF AIR POLLUTANTS EMISSIONS BY THE AIRPORT EXPANSION AND ASSOCIATED INFRASTRUCTURE - CASE STUDY OF THE EXTENSION OF VIRACOPOS AIRPORT AT CAMPINAS, SÃO PAULO, BRAZIL

Directory of Open Access Journals (Sweden)

Lucia H.G. Coelho

2016-01-01

Full Text Available The development of the airport segment faces environmental externalities especially related to the increase in emissions of Greenhouse Gases (GHGs from combustion of fossil fuels by the aircraft engine, by the machinery for the maintenance of the planes and also by the vehicles used for passengers connections (private cars, taxicabs or public transportation system. In this scope, the current work presents the case study of the expansion of the Viracopos International Airport at Campinas – São Paulo, Brazil. To evaluate that, the methodology of the Intergovernmental Panel on Climate Change (IPCC was implemented to estimate the emissions of GHGs by aircraft for the years 2008 (before expansion, 2012 (current picture and 2018 (future scenario observing the changes in demand for passengers and cargo transportation. To evaluate the emissions from the vehicles it was used the AIMSUN microsimulation software to estimate emissions in the years 2012 and to simulate sensitivity scenarios for the year 2018. It was found that the inventory of CO2 emissions for both types of transports considered for the Viracopos airport showed similar orders of magnitude, what can be inferred about the equivalent contribution of these two modes on emissions of GHGs for the study area. These results may serve as a basis for establishing emission management plans of air pollutants by the competent organizations and to propose more targeted and effective measures to reduce the GHG emissions by these sources.

Airport mobile marketing as a channel to promote cross-selling

Directory of Open Access Journals (Sweden)

Lázaro Florido-Benítez

2016-12-01

Full Text Available Purpose: The purpose of this study is to analyze the airport mobile marketing and what elements have had a positive or negative influence in cross-selling via an airport app.  Design/methodology: For this analysis, a survey was conducted to users that use the Schiphol Amsterdam Airport app. A total of 103 questionnaires were analyzed using structural equation modeling.  Findings: This study found that security/control factor supplied by the mobile marketing tool to passengers at the airport, it has been demonstrated that it favours an increase in cross-selling. in addition, if an airport is perceived to have a good brand image, it will have a positive effect in cross-selling.  Originality/value: This paper is the first research that examines the impact of mobile marketing in airports. Smelling multiple products and services to the same client before, during, and post consumption  is a marketing technique that intends to (1 satisfy a client’s need and (2 increase a company’s profit by using cross-selling and other complementary services. Airline companies are experts in carrying out this activity, and airports have found that mobile applications are the perfect tool to increase their commercial profits. Offering complementary products and services is a very lucrative business, and a mobile device or smartphone are -- and will become -- the ideal medium to meet users’ demands as well as to improve the passenger experience.  Keywords: mobile marketing, cross-selling, information, security-control, image-perception, satisfaction, WOM

23 Ekim 2011 Tabanlı-Van Depreminin Sismik Jeomorfolojisi ve Doğu Anadolu’daki Aktif Tektonik Yapılarla Olan İlişkisi

OpenAIRE

Özkaymak, Çağlar; Sözbilir, Hasan; Bozkurt, Erdin; Dirik, Kadir; Topal, Tamer; Alan, Hüseyin; Çağlan, Dündar

2011-01-01

Bu çalışma, 23 Ekim 2011 tarihindemeydana gelen Tabanlı-Van (M = 7.2) depreminin bölgenin aktif tektoniğiiçerisindeki konumunu açıklamayı amaçlamaktadır. Bu bağlamda Tabanlı-Van depremindensonra arazi çalışmaları yapılmış, depremle ilişkili deformasyon yapılarıincelenmiş ve arazi gözlemlerinden elde edilen veriler ile Van ili veçevresiyle ilgili olarak daha önce yapılmış aktif tektonik çalışmalarıkarşılaştırılarak değerlendirmeye gidilmiştir. Depremsırasında veya hemen sonrasında yeryüzünde/y...

17-AAG suppresses growth and invasion of lung adenocarcinoma cells via regulation of the LATS1/YAP pathway

Science.gov (United States)

Ye, Xiang-Yun; Luo, Qing-Quan; Xu, Yun-Hua; Tang, Nai-Wang; Niu, Xiao-Min; Li, Zi-Ming; Shen, Sheng-Ping; Lu, Shun; Chen, Zhi-Wei

2015-01-01

The large tumour suppressor 1 (LATS1) signalling network has been proved to be an essential regulator within the cell, participating in multiple cellular phenotypes. However, it is unclear concerning the clinical significance of LATS1 and the regulatory mechanisms of 17-Allylamino-17- demethoxygeldanamycin (17-AAG) in lung adenocarcinoma (LAC). The aim of the present study was to investigate the correlation of LATS1 and yes-associated protein (YAP) expression with clinicopathological characteristics in LAC patients, and the effects of 17-AAG on biological behaviours of LAC cells. Subcutaneous LAC tumour models were further established to observe the tumour growth in nude mice. The results showed that the positive expression of LATS1 was significantly lowered (26.7% versus 68.0%, P AAG inhibited proliferation and invasion, and induced cell apoptosis and cycle arrest in LAC cells together with increased expression of E-cadherin and p-LATS1, and decreased expression of YAP and connective tissue growth factor. Tumour volumes and weight were much smaller in 17-AAG-treated groups than those in untreated group (P AAG suppresses growth and invasion of LAC cells via regulation of the LATS1/YAP pathway in vitro and in vivo, suggesting that we may provide a promising therapeutic strategy for the treatment of human LAC. PMID:25712415

Air quality modeling for community-scale assessments around airports

Science.gov (United States)

Transportation infrastructure (including roadway traffic, ports, and airports) is critical to the nation’s economy. With a growing economy, aircraft activity is expected to grow across the world, and in the U.S. airport-related emissions, while generally small, are not an i...

The importance of agglomeration effects for distribution centres around Amsterdam Airport Schiphol

NARCIS (Netherlands)

Warffemius, P.; van der Hoorn, T.; Klaassen, H.

2010-01-01

Amsterdam Airport Schiphol is a main European airport and represents an important concentration of European distribution centres (EDCs). It is commonly assumed that distribution centres are attracted to the airport region because of its air transport services. However, if one considers economies of

Roles of the Yap1 transcription factor and antioxidants in Saccharomyces cerevisiae's tolerance to furfural and 5-hydroxymethylfurfural, which function as thiol-reactive electrophiles generating oxidative stress.

Science.gov (United States)

Kim, Daehee; Hahn, Ji-Sook

2013-08-01

Development of the tolerance of Saccharomyces cerevisiae strains to furfural and 5-hydroxymethylfurfural (HMF) is an important issue for cellulosic ethanol production. Although furfural and HMF are known to induce oxidative stress, the underlying mechanisms are largely unknown. In this study, we show that both furfural and HMF act as thiol-reactive electrophiles, thus directly activating the Yap1 transcription factor via the H2O2-independent pathway, depleting cellular glutathione (GSH) levels, and accumulating reactive oxygen species in Saccharomyces cerevisiae. However, furfural showed higher reactivity than did HMF toward GSH in vitro and in vivo. In line with such toxic mechanisms, overexpression of YAP1(C620F), a constitutively active mutant of YAP1, and Yap1 target genes encoding catalases (CTA1 and CTT1) increased tolerance to furfural and HMF. However, increasing GSH levels by overexpression of genes for GSH biosynthesis (GSH1 and GLR1) or by the exogenous addition of GSH to the culture medium enhanced tolerance to furfural but not to HMF.

The Correlations between Airport Sustainability and Indonesian Economic Growth

Science.gov (United States)

Setiawan, M. I.; Dhaniarti, I.; Utomo, W. M.; Sukoco, A.; Mudjanarko, S. W.; Hasyim, C.; Prasetijo, J.; Kurniasih, N.; Wajdi, M. B. N.; Purworusmiardi, T.; Suyono, J.; Sudapet, I. N.; Nasihien, R. D.; Wulandari, D. A. R.; Ade, R. T.; Atmaja, W. M. T.; Sugeng; Wulandari, A.

2018-04-01

This study aims to analyze the correlation between airport performances with Gross domestic product-regional (GDP-regional) performance. This research uses quantitative research method with correlation study approach. Based on the T-Value Test Result, the T-value for the Airport Performance variable is 14,264. T-Value Test Results and compared with T-table equal to 1,976 (significant level 0,05) hence T-count> T-table so variable of Airport Perform predicted have significant correlation to GDP-regional. This means that good airport performance will either improve the performance of Water supply, Sewerage, Waste Management and Remediation Activities; Wholesale and Retail Trade; Repair of Motor Vehicles and Motorcycles; Accommodation and Food Service Activities; Financial and Insurance Activities; Business Activities; Public Administration and Defence; Compulsory Social Security; Education; Human Health and Social Work Activities; Other Services Activities; Manufacturing; and Electricity and Gas, better.

Fast Automatic Airport Detection in Remote Sensing Images Using Convolutional Neural Networks

Directory of Open Access Journals (Sweden)

Fen Chen

2018-03-01

Full Text Available Fast and automatic detection of airports from remote sensing images is useful for many military and civilian applications. In this paper, a fast automatic detection method is proposed to detect airports from remote sensing images based on convolutional neural networks using the Faster R-CNN algorithm. This method first applies a convolutional neural network to generate candidate airport regions. Based on the features extracted from these proposals, it then uses another convolutional neural network to perform airport detection. By taking the typical elongated linear geometric shape of airports into consideration, some specific improvements to the method are proposed. These approaches successfully improve the quality of positive samples and achieve a better accuracy in the final detection results. Experimental results on an airport dataset, Landsat 8 images, and a Gaofen-1 satellite scene demonstrate the effectiveness and efficiency of the proposed method.

The impact of high speed rail on airport competition

NARCIS (Netherlands)

Terpstra, I.; Lijesen, M.G.

2015-01-01

We study the effects of introducing a high speed train connection on competition between airports, focusing on the new HST-link between Amsterdam and Brussels. We conduct a detailed analysis regarding the airport choice of passengers living in the Netherlands, Belgium, Luxembourg, Northern France

Pittsburgh International Airport - Scheduled Passenger Traffic

Data.gov (United States)

Allegheny County / City of Pittsburgh / Western PA Regional Data Center — Here you can find Pittsburgh International Airport’s Monthly Scheduled Traffic Reports. Each of these reports contain a year-over-year (YOY) analysis of scheduled...

SAR Raw Data Generation for Complex Airport Scenes

Directory of Open Access Journals (Sweden)

Jia Li

2014-10-01

Full Text Available The method of generating the SAR raw data of complex airport scenes is studied in this paper. A formulation of the SAR raw signal model of airport scenes is given. Via generating the echoes from the background, aircrafts and buildings, respectively, the SAR raw data of the unified SAR imaging geometry is obtained from their vector additions. The multipath scattering and the shadowing between the background and different ground covers of standing airplanes and buildings are analyzed. Based on the scattering characteristics, coupling scattering models and SAR raw data models of different targets are given, respectively. A procedure is given to generate the SAR raw data of airport scenes. The SAR images from the simulated raw data demonstrate the validity of the proposed method.

78 FR 55330 - Policy Regarding Airport Rates and Charges

Science.gov (United States)

2013-09-10

... center, headquarters office, or flight kitchen on an airport does not constitute an aeronautical use... flights subsidized under the Essential Air Service Program from the general application of a 2-part... address congestion. 6.3 An airport proprietor may exempt flights subsidized under the Essential Air...

The employment and income benefits of airport operation on the country in transition

Directory of Open Access Journals (Sweden)

Sonia Huderek-Glapska

2013-03-01

Full Text Available Background: The air transport market in Poland is undergoing significant changes, which take place both on the demand and supply side. Polish airports have experienced the unprecedented growth of air traffic. However, the increase in the number of airline connections - which benefits airports, passengers, aircraft industry and, indirectly, the whole society - at the same time results in the growth of social costs reflected by the intensification of noise and environmental pollution. The benefits of airport operation are reflected in the generation of employment and income. Existing literature reveals a gap in the knowledge in respect of impact of aviation in countries in transition. Material and methods: This paper investigates the applicability of socio-economic impact of air transport model to country in transition. In particular, it presents the employment and income benefits of airport operation. The input-output model is employed to measure the economic benefits of airport operation. The largest airport in Poland, Warsaw Chopin Airport is used as a case study. Results: The estimation results for the income and employment effects are found to be significant.  The operations of Warsaw Chopin Airport contributed to the generation of 527.8m EUR in current prices in 2011. Altogether, 19,349 jobs have been generated as the result of the direct, indirect and induced impact of Warsaw Chopin Airport.  Conclusion:  The size of production in the airport expressed in the number of aircraft operations and the number of passengers and goods serviced is positively correlated with the level of economic impact. The restriction on the development of the airport reflected by the inability to meet transport needs expressed by the society may generate opportunity costs.  

Lidar Wind Profiler for the NextGen Airportal, Phase II

Data.gov (United States)

National Aeronautics and Space Administration — The development of a standoff sensor that can measure 3D components of wind velocity in the vicinity of an airport has the potential to improve airport throughput,...

Important influencing factors analysis of airport sustainable development capacity: The case of China

Directory of Open Access Journals (Sweden)

Qiang Cui

2013-09-01

Full Text Available Purpose: This paper seeks to define and build the formation mechanism for airport sustainable development capacity.Design/methodology/approach: Structure Equation and System Dynamic Model are used to research the formation mechanism of airport sustainable development capacity.Findings: The most influencing factors are: airport own investment, Gross Domestic Product and power consumption of unit income.Originality/value: Firstly, a new concept to evaluate the dynamic work on sustainable development is proposed, which is defined as airport sustainable development capacity.  Secondly, the formation mechanism of airport sustainable development capacity is studied through Structure Equation Model and System Dynamics model. It fills in the gap of existing research whose main focus is static evaluation of airport sustainable development capacity and influencing factors identification rather than dynamic formation mechanism.

Efficient airport detection using region-based fully convolutional neural networks

Science.gov (United States)

Xin, Peng; Xu, Yuelei; Zhang, Xulei; Ma, Shiping; Li, Shuai; Lv, Chao

2018-04-01

This paper presents a model for airport detection using region-based fully convolutional neural networks. To achieve fast detection with high accuracy, we shared the conv layers between the region proposal procedure and the airport detection procedure and used graphics processing units (GPUs) to speed up the training and testing time. For lack of labeled data, we transferred the convolutional layers of ZF net pretrained by ImageNet to initialize the shared convolutional layers, then we retrained the model using the alternating optimization training strategy. The proposed model has been tested on an airport dataset consisting of 600 images. Experiments show that the proposed method can distinguish airports in our dataset from similar background scenes almost real-time with high accuracy, which is much better than traditional methods.

Air Pollution Effects on Aircrafts Movement in and Around Airport: Solutions and Recommendations (Case Study: Djalaluddin Airport, Gorontalo, Indonesia)

OpenAIRE

Adisaamita, Sakti Adji

2014-01-01

- The study was conducted by collecting information/data from Djalaluddin airport, Gorontalo, Indonesia in order to measure, prevent or minimize the air pollution impacts on airports and its surrounding, such that air pollution impacts can be managed and monitored effectively and efficiently not only in the current situation but also in the future conditions. The data used were primary and secondary data. The primary data were based on field survey, interview and discussion with official g...

Learning from history: The Glasgow Airport terrorist attack.

Science.gov (United States)

Crichton, Gillies

Glasgow Airport was the target of a terrorist attack on 30th June, 2007. Many people within Scotland had come to believe that Scotland was immune from terrorism. This perception was in large part informed by Scotland's experience during the protracted Troubles in Northern Ireland, during which the Provisional Irish Republican Army's mainland bombing campaign focused on targets in England, sparing both Scotland and Wales. While Glasgow Airport did not expect such an attack to take place, meticulous planning, organising and testing of plans had taken place to mitigate the unlikely event of such an attack. The attack stands up as a shining example of robust business continuity management, where the airport reopened for business as usual in less than 24 hours from the time of the attack. Little is known about how the airport handled the situation in conjunction with other responding agencies as people tend to want to focus on high-profile disasters only. Yet countless such incidents are happening worldwide on a daily basis, in which there are excellent learning opportunities, and, taken in the spirit of converting hindsight into foresight, the likelihood of similar incidents could potentially be reduced in the future.

77 FR 22376 - Airport Improvement Program (AIP) Grant Assurances

Science.gov (United States)

2012-04-13

... established after December 30, 1987, will be expended by it for the capital or operating costs of the airport... structures (such as runways, taxiways, aprons, terminal buildings, hangars, and roads), including all... the Airport and Airway Trust Fund. * * * * * Issued in Washington, DC on April 10, 2012. Benito De...

Public Use Airport Runways, Geographic WGS84, BTS (2006) [public_use_airport_runway_BTS_2006

Data.gov (United States)

Louisiana Geographic Information Center — The Public Use Airport Runways database is a geographic dataset of runways in the United States and US territories containing information on the physical...

Impact of atmospheric particulate matter pollutants to IAQ of airport terminal buildings: A first field study at Tianjin Airport, China

Science.gov (United States)

Ren, Jianlin; Cao, Xiaodong; Liu, Junjie

2018-04-01

Passengers usually spend hours in the airport terminal buildings waiting for their departure. During the long waiting period, ambient fine particles (PM2.5) and ultrafine particles (UFP) generated by airliners may penetrate into terminal buildings through open doors and the HVAC system. However, limited data are available on passenger exposure to particulate pollutants in terminal buildings. We conducted on-site measurements on PM2.5 and UFP concentration and the particle size distribution in the terminal building of Tianjin Airport, China during three different seasons. The results showed that the PM2.5 concentrations in the terminal building were considerably larger than the values guided by Chinese standard and WHO on all of the tested seasons, and the conditions were significantly affected by the outdoor air (Spearman test, p air quality and health of passengers in airport terminal buildings.

Methods for determining unimpeded aircraft taxiing time and evaluating airport taxiing performance

Directory of Open Access Journals (Sweden)

Yu Zhang

2017-04-01

Full Text Available The objective of this study is to improve the methods of determining unimpeded (nominal taxiing time, which is the reference time used for estimating taxiing delay, a widely accepted performance indicator of airport surface movement. After reviewing existing methods used widely by different air navigation service providers (ANSP, new methods relying on computer software and statistical tools, and econometrics regression models are proposed. Regression models are highly recommended because they require less detailed data and can serve the needs of general performance analysis of airport surface operations. The proposed econometrics model outperforms existing ones by introducing more explanatory variables, especially taking aircraft passing and over-passing into the considering of queue length calculation and including runway configuration, ground delay program, and weather factors. The length of the aircraft queue in the taxiway system and the interaction between queues are major contributors to long taxi-out times. The proposed method provides a consistent and more accurate method of calculating taxiing delay and it can be used for ATM-related performance analysis and international comparison.

Z Specification of Gate and Apron Control Management at Airport

Directory of Open Access Journals (Sweden)

Nazir Ahmad Zafar

2014-01-01

Full Text Available Modelling of an air traffic control (ATC system is an open issue and has become a challenging problem due to its complexity and increase of traffic at airports and in airspace. Consequently, automated ATC systems are suggested to improve efficiency ensuring the safety standards. It is reported that the number of collisions that occurred at airports surface is three times larger than in airspace. Further, it is observed that gates and aprons congestions cause significant delays at airports; hence, effective monitoring and guidance mechanisms are required to control ground air traffic. In this paper, formal procedure of managing air traffic from gate to enter in the active area of airport for taxiing is provided using Z notation. An integration of gate and apron controllers is described to manipulate the information for correct decision making and flow management. Graph theory is used for representation of airport topology and appropriate routs. In static part of the model, safety properties are described in terms of invariants over the critical data types. In dynamic model, the state space is updated by defining pre- and postconditions ensuring the safety. Formal specification is analysed using Z/Eves tool.

17-AAG suppresses growth and invasion of lung adenocarcinoma cells via regulation of the LATS1/YAP pathway.

Science.gov (United States)

Ye, Xiang-Yun; Luo, Qing-Quan; Xu, Yun-Hua; Tang, Nai-Wang; Niu, Xiao-Min; Li, Zi-Ming; Shen, Sheng-Ping; Lu, Shun; Chen, Zhi-Wei

2015-03-01

The large tumour suppressor 1 (LATS1) signalling network has been proved to be an essential regulator within the cell, participating in multiple cellular phenotypes. However, it is unclear concerning the clinical significance of LATS1 and the regulatory mechanisms of 17-Allylamino-17- demethoxygeldanamycin (17-AAG) in lung adenocarcinoma (LAC). The aim of the present study was to investigate the correlation of LATS1 and yes-associated protein (YAP) expression with clinicopathological characteristics in LAC patients, and the effects of 17-AAG on biological behaviours of LAC cells. Subcutaneous LAC tumour models were further established to observe the tumour growth in nude mice. The results showed that the positive expression of LATS1 was significantly lowered (26.7% versus 68.0%, P AAG inhibited proliferation and invasion, and induced cell apoptosis and cycle arrest in LAC cells together with increased expression of E-cadherin and p-LATS1, and decreased expression of YAP and connective tissue growth factor. Tumour volumes and weight were much smaller in 17-AAG-treated groups than those in untreated group (P AAG suppresses growth and invasion of LAC cells via regulation of the LATS1/YAP pathway in vitro and in vivo, suggesting that we may provide a promising therapeutic strategy for the treatment of human LAC. © 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

Airport object extraction based on visual attention mechanism and parallel line detection

Science.gov (United States)

Lv, Jing; Lv, Wen; Zhang, Libao

2017-10-01

Target extraction is one of the important aspects in remote sensing image analysis and processing, which has wide applications in images compression, target tracking, target recognition and change detection. Among different targets, airport has attracted more and more attention due to its significance in military and civilian. In this paper, we propose a novel and reliable airport object extraction model combining visual attention mechanism and parallel line detection algorithm. First, a novel saliency analysis model for remote sensing images with airport region is proposed to complete statistical saliency feature analysis. The proposed model can precisely extract the most salient region and preferably suppress the background interference. Then, the prior geometric knowledge is analyzed and airport runways contained two parallel lines with similar length are detected efficiently. Finally, we use the improved Otsu threshold segmentation method to segment and extract the airport regions from the salient map of remote sensing images. The experimental results demonstrate that the proposed model outperforms existing saliency analysis models and shows good performance in the detection of the airport.

Electric Ground Support Equipment at Airports

Energy Technology Data Exchange (ETDEWEB)

2017-12-12

Airport ground support equipment (GSE) is used to service airplanes between flights. Services include refueling, towing airplanes or luggage/freight carts, loading luggage/freight, transporting passengers, loading potable water, removing sewage, loading food, de-icing airplanes, and fire-fighting. Deploying new GSE technologies is a promising opportunity in part because the purchasers are generally large, technologically sophisticated airlines, contractors, or airports with centralized procurement and maintenance departments. Airlines could particularly benefit from fuel diversification since they are highly exposed to petroleum price volatility. GSE can be particularly well-suited for electrification because it benefits from low-end torque and has frequent idle time and short required ranges.

Airports at Risk: The Impact of Information Sources on Security Decisions

OpenAIRE

Kirschenbaum, Avi; Mariani, Michele; Van Gulijk, Coen; Rapaport, Carmit; Lubasz, Sharon

2012-01-01

Security decisions in high risk organizations such as airports involve obtaining ongoing and frequent information about potential threats. Utilizing questionnaire survey data from a sample of airport\\ud employees in European Airports across the continent, we analyzed \\ud how both formal and informal sources of security information affect employee's decisions to comply with the security rules and\\ud directives. This led us to trace information network flows to assess its impact on the degree e...

Türkiye’de süs bitkileri sektörünün üretim ve yapısal sorunları ve öneriler

OpenAIRE

ONAY, Hatice Aslı

2008-01-01

ÖZET:

Bu tez çalışması Türkiye’de süs bitkileri sektörünün üretim ve yapısal sorunlarını analiz ederek bunlara yapıcı ve sürdürülebilir çözümler üretmek amacıyla yapılmıştır. Bunun için öncelikle sektörün ülkemizdeki mevcut durumu ortaya konulmaya çalışılmıştır. Mevcut durumu ortaya koymak için ise sektörün üretim, ithalat ve ihracat verilerinden yararlanılmıştır. Birçok kurum ve kuruluşlardan edinilen bu veriler ışığında sekt...

LH2 airport requirements study

Science.gov (United States)

Brewer, G. D. (Editor)

1976-01-01

A preliminary assessment of the facilities and equipment which will be required at a representative airport is provided so liquid hydrogen LH2 can be used as fuel in long range transport aircraft in 1995-2000. A complete facility was conceptually designed, sized to meet the projected air traffic requirement. The facility includes the liquefaction plant, LH2, storage capability, and LH2 fuel handling system. The requirements for ground support and maintenance for the LH2 fueled aircraft were analyzed. An estimate was made of capital and operating costs which might be expected for the facility. Recommendations were made for design modifications to the reference aircraft, reflecting results of the analysis of airport fuel handling requirements, and for a program of additional technology development for air terminal related items.

78 FR 15804 - Waiver of Aeronautical Land-Use Assurance: Rolla National Airport (VIH), Rolla, MO

Science.gov (United States)

2013-03-12

... Assurance: Rolla National Airport (VIH), Rolla, MO AGENCY: Federal Aviation Administration (FAA), DOT... request to change approximately 10 acres of airport property at the Rolla National Airport (VIH) from... following is a brief overview of the request: The Rolla National Airport (VIH) is proposing the release of...

Determining the sensitivity of Data Envelopment Analysis method used in airport benchmarking

Directory of Open Access Journals (Sweden)

Mircea BOSCOIANU

2013-03-01

Full Text Available In the last decade there were some important changes in the airport industry, caused by the liberalization of the air transportation market. Until recently airports were considered infrastructure elements, and they were evaluated only by traffic values or their maximum capacity. Gradual orientation towards commercial led to the need of finding another ways of evaluation, more efficiency oriented. The existing methods for assessing efficiency used for other production units were not suitable to be used in case of airports due to specific features and high complexity of airport operations. In the last years there were some papers that proposed the Data Envelopment Analysis as a method for assessing the operational efficiency in order to conduct the benchmarking. This method offers the possibility of dealing with a large number of variables of different types, which represents the main advantage of this method and also recommends it as a good benchmarking tool for the airports management. This paper goal is to determine the sensitivity of this method in relation with its inputs and outputs. A Data Envelopment Analysis is conducted for 128 airports worldwide, in both input- and output-oriented measures, and the results are analysed against some inputs and outputs variations. Possible weaknesses of using DEA for assessing airports performance are revealed and analysed against this method advantages.

A Novel Surveillance System Applied in Civil Airport

Directory of Open Access Journals (Sweden)

Sun Hua Bo

2016-01-01

Full Text Available Conventional security monitoring of civil airport usually uses a fixed camera to acquire images. There are several problems with performance including difficulties introduced in the information transmission, storage, and analysis of the process. Insect compound eyes offer unique advantages for moving target capture and these have attracted the attention of many researchers in recent years. This paper contributes to this research by proposing a new surveillance system applied in civil airport. We discuss the finished bionic structure of the system, the development of the bionic control circuit, and introduce the proposed mathematical model of bionic compound eyes for data acquisition and image mosaic. Image matching for large view is also illustrated with different conditions. This mode and algorithm effectively achieve safety surveillance of airport with large field of view and high real-time processing.