The Analysis of Fourth Adventure of Seven-Adventures of Iranian National Epic based on Myth

Directory of Open Access Journals (Sweden)

GH Ebrahimi

2012-08-01

Full Text Available The seven-adventures of Rostam, in particular, and other Iranian seven-adventures such as Esfandyar seven-adventures or Gorshasp pseudo-seven-adventures are a kind of eternity search, a kind of battle with selfhood that aims to facilitate the problems, the difficulties of evolution way and human ascent. By discussing and analyzing Iranian seven-adventures, this research aims to study the fourth adventure of all the seven-adventures, which is, at the surface, the battle between man (hero, champion and woman but, in essence, it is the battle between fire and water. Fire is the son of Ahura Mazda and water is its enemy. Water, which was at one time the symbol of holiness and purity of Ahura, became a satanic element during Sassanid era and following the dominance of Zorvani thoughts on religious system of that time. By analyzing Rostam, Esfandyar, Gorshasp, Heracles fourth adventure and looking at Zal and Roodabe stories, Khajavi Kermani’s Sam-Nameh, Nezemi’s Khosro and Shirin and Mahmoud Dolatabadi’s Kalidar, we try to prove this hypothesis.

A Review of Adventure Learning

Directory of Open Access Journals (Sweden)

George Veletsianos

2009-12-01

Full Text Available Adventure learning (AL is an approach for the design of digitally-enhanced teaching and learning environments driven by a framework of guidelines grounded on experiential and inquiry-based education. The purpose of this paper is to review the adventure learning literature and to describe the status quo of the practice by identifying the current knowledge, misconceptions, and future opportunities in adventure learning. Specifically, the authors present an integrative analysis of the adventure learning literature, identify knowledge gaps, present future research directions, and discuss research methods and approaches that may improve the AL approach.The authors engaged in a systematic search strategy to identify adventure learning studies then applied a set of criteria to decide whether to include or exclude each study. Results from the systematic review were combined, analyzed, and critiqued inductively using the constant comparative method and weaved together using the qualitative metasynthesis approach.Results indicate the appeal and promise of the adventure learning approach. Nevertheless, the authors recommend further investigation of the approach. Along with studies that investigate learning outcomes, aspects of the AL approach that are engaging, and the nature of expert-learner collaboration, future adventure learning projects that focus on higher education and are (a small and (b diverse can yield significant knowledge into adventure learning. Research and design in this area will benefit by taking an activity theory and design-based research perspective.

Data Adventures

DEFF Research Database (Denmark)

A B Barros, Gabriella; Liapis, Antonios; Togelius, Julian

2015-01-01

This paper outlines a system for generating adventure games based on open data, and describes a sketch of the system im- plementation at its current state. The adventure game genre has been popular for a long time and diers signicantly in design priorities from game genres which are commonly ad......- dressed in PCG research. In order to create believable and engaging content, we use data from DBpedia to generate the game's non-playable characters locations and plot, and OpenStreetMaps to create the game's levels...

Safety in New Zealand's adventure tourism industry: the client accident experience of adventure tourism operators.

Science.gov (United States)

Bentley , T A; Page, S J; Laird, I S

2000-01-01

Injuries and fatalities among participants of adventure tourism activities have the potential to seriously impact on New Zealand's tourism industry. However, the absence of statistics for tourist accidents in New Zealand, and the lack of detailed academic research into adventure tourism safety, means the extent of the problem is unknown. The aims of the present study were to determine the incidence of client injuries across a range of adventure tourism activity sectors, and to identify common accident events and contributory risk factors. A postal questionnaire survey of New Zealand adventure tourism operators was used. Operators were asked to provide information related to their business; the number of recorded client injuries during the preceding 12 month period, January to December 1998; common accident and injury events associated with their activity; and perceived risk factors for accidents in their sector of the adventure tourism industry. The survey was responded to by 142 New Zealand adventure tourism operators. The operators' reported client injury experience suggests the incidence of serious client injuries is very low. Highest client injury incidence rates were found for activities that involved the risk of falling from a moving vehicle or animal (e.g., cycle tours, quad biking, horse riding, and white-water rafting). Slips, trips, and falls on the level were common accident events across most sectors of the industry. Perceived accident/incident causes were most commonly related to the client, and in particular, failure to attend to and follow instructions. The prevalence of client injuries in activity sectors not presently covered by government regulation, suggests policy makers should look again at extending codes of practice to a wider range of adventure tourism activities. Further research considering adventure tourism involvement in overseas visitor hospitalized injuries in New Zealand, is currently in progress. This will provide supporting evidence

Fostering Experiential Self-Regulation through Outdoor Adventure Education

Science.gov (United States)

Sibthorp, Jim; Collins, Rachel; Rathunde, Kevin; Paisley, Karen; Schumann, Scott; Pohja, Mandy; Gookin, John; Baynes, Sheila

2015-01-01

Learners thrive when they have the capacity to regulate interest and goal direction. Through direct experiences that are interesting and goal-relevant, learners can internalize and better understand their own agency in the learning process. This article further examines this premise in an outdoor adventure education (OAE) context through two…

Marketing of adventure tourism destination in Nepal

OpenAIRE

Baral, Nirajan

2016-01-01

Adventure tourism is one of the key factors of the Nepalese tourism industry. The main aim of this bachelor’s thesis was to clarify the current situation and challenges for developing adventure tourism in Nepal and to evaluate the importance of appropriate marketing strategies. The thesis also focuses on promoting adventure tourism activities and rural tourism destinations. The objective of the thesis was to explore Dhorpatan Hunting Reserve as an adventure tourism destination at internationa...

DEMOGRAPHIC PROFILE OF ADVENTURE TOURISTS IN PRETORIA

OpenAIRE

Melissa Jeanette Lötter; Sue Geldenhuys; Marius Potgieter

2012-01-01

It is difficult to examine different motivations and segment differentiations in niche markets such as adventure tourism seeing that it is not a well-defined segment in the discipline of tourism studies. In order to assist adventure tourism companies towards identifying and developing effective marketing strategies to attract or penetrate the adventure niche market, this study aims to contribute towards the current understanding of adventure tourists in Pretoria by compiling a demographic pro...

Injuries to New Zealanders participating in adventure tourism and adventure sports: an analysis of Accident Compensation Corporation (ACC) claims.

Science.gov (United States)

Bentley, Tim; Macky, Keith; Edwards, Jo

2006-12-15

The aim of this study was to examine the involvement of adventure tourism and adventure sports activity in injury claims made to the Accident Compensation Corporation (ACC). Epidemiological analysis of ACC claims for the period, July 2004 to June 2005, where adventure activities were involved in the injury. 18,697 adventure tourism and adventure sports injury claims were identified from the data, representing 28 activity sectors. Injuries were most common during the summer months, and were most frequently located in the major population centres. The majority of injuries were incurred by claimants in the 20-50 years age groups, although claimants over 50 years of age had highest claims costs. Males incurred 60% of all claims. Four activities (horse riding, mountain biking, tramping/hiking, and surfing) were responsible for approximately 60% of all adventure tourism and adventure sports-related injuries. Slips, trips, and falls were the most common injury initiating events, and injuries were most often to the back/spine, shoulder, and knee. These findings suggest the need to investigate whether regulatory intervention in the form of codes of practice for high injury count activities such as horse riding and mountain biking may be necessary. Health promotion messages and education programs should focus on these and other high-injury risk areas. Improved risk management practices are required for commercial adventure tourism and adventure sports operators in New Zealand if safety is to be improved across this sector.

Outdoor Adventure Programs Fulfilling Heroic Archetypal Patterns.

Science.gov (United States)

Lee, Johnny

The experiences found in adventure programs often parallel the archetypes depicted in mythological quests. Drawing on the work of Joseph Campbell, the stages and trials of adventure participants are compared to similar rites of passage and epic adventures experienced by heroes and heroines in epic literature and mythology. The basic pattern of…

Safe adventures. An ethnographic study of safety and adventure guides in Arctic Norway

OpenAIRE

Johannessen, Mats Hoel

2016-01-01

With numerous entrepreneurs already established within the area, adventure tourism is a growing industry within Arctic Norway. The continuously expanding interest for the phenomenon has gained universities’ attention with recent education programs for guides being established. A cultural change involving a more professionalized approach to adventure tourism has also been noticed. At the forefront of ensuring tourists’ safety are the guides, who work in the area. In former research on safety i...

All-Girls Adventure Programmes: What Are the Benefits?

Science.gov (United States)

Whittington, Anja; Mack, Erica Nixon; Budbill, Nadine W.; McKenney, Priscilla

2011-01-01

This study examined the benefits of all-girls adventure programmes from the perspective of adolescent girls. Participants included 361 girls aged 10-17 years from diverse ethnic and socio-economic backgrounds who completed a variety of adventure programmes. Adventure activities included rock climbing, sea kayaking, mountaineering, backpacking,…

Adventure Learning: Theory and Implementation of Hybrid Learning

Science.gov (United States)

Doering, A.

2008-12-01

Adventure Learning (AL), a hybrid distance education approach, provides students and teachers with the opportunity to learn about authentic curricular content areas while interacting with adventurers, students, and content experts at various locations throughout the world within an online learning environment (Doering, 2006). An AL curriculum and online environment provides collaborative community spaces where traditional hierarchical classroom roles are blurred and learning is transformed. AL has most recently become popular in K-12 classrooms nationally and internationally with millions of students participating online. However, in the literature, the term "adventure learning" many times gets confused with phrases such as "virtual fieldtrip" and activities where someone "exploring" is posting photos and text. This type of "adventure learning" is not "Adventure Learning" (AL), but merely a slideshow of their activities. The learning environment may not have any curricular and/or social goals, and if it does, the environment design many times does not support these objectives. AL, on the other hand, is designed so that both teachers and students understand that their online and curriculum activities are in synch and supportive of the curricular goals. In AL environments, there are no disparate activities as the design considers the educational, social, and technological affordances (Kirschner, Strijbos, Kreijns, & Beers, 2004); in other words, the artifacts of the learning environment encourage and support the instructional goals, social interactions, collaborative efforts, and ultimately learning. AL is grounded in two major theoretical approaches to learning - experiential and inquiry-based learning. As Kolb (1984) noted, in experiential learning, a learner creates meaning from direct experiences and reflections. Such is the goal of AL within the classroom. Additionally, AL affords learners a real-time authentic online learning experience concurrently as they

Inside/outside the Western 'Bubble': The nexus of adventure, adventure sports and perceptions of risk in UK and Mauritius

OpenAIRE

Humberstone, Barbara

2009-01-01

Globalization can be thought of as the widening, deepening and quickening of the worldwide interconnections in social, cultural, political and economic life (Held et al., 1999). For adventure sports enthusiasts from the West, this has opened up the world for them to pursue their activities in more ‘exotic’ natural locations. Marketing of adventure holidays has increased with the greater ease of travelling to suitable geographical locations, providing apparently ‘authentic’ adventure experienc...

Empowerment and women in adventure tourism : a negotiated journey

OpenAIRE

Doran, Adele

2016-01-01

Women’s participation in adventure tourism is growing, yet few studies have explored this group of tourists. This conceptual paper seeks to extend our understanding of female adventure tourists by examining the empowering journey women can take through constraint negotiation to enjoy the benefits of adventure tourism. Using content analysis to review the literature on women’s adventure experiences in tourism and recreation settings reveals prominent themes that have been consolidated to propo...

Biophysical and biomathematical adventures in radiobiology

International Nuclear Information System (INIS)

Scott, B.R.

1991-01-01

Highlights of my biophysical and biomathematical adventures in radiobiology is presented. Early adventures involved developing ''state-vector models'' for specific harmful effects (cell killing, life shortening) of exposure to radiation. More recent adventures led to developing ''hazard-function models'' for predicting biological effects (e.g., cell killing, mutations, tumor induction) of combined exposure to different toxicants. Hazard-function models were also developed for predicting harm to man from exposure to large radiation doses. Major conclusions derived from the modeling adventures are as follows: (1) synergistic effects of different genotoxic agents should not occur at low doses; (2) for exposure of the lung or bone marrow to large doses of photon radiation, low rates of exposure should be better tolerated than high rates; and (3) for some types of radiation (e.g., alpha particles and fission neutrons), moderate doses delivered at a low rate may be more harmful than the same dose given at a high rate. 53 refs., 7 figs

Teamwork in adventure racing

OpenAIRE

Šavrňák, Ondřej

2011-01-01

Title: Teamwork in Adventure racing Goals: The main goal is to make up the chapter about an ideal teamwork in Adventure racing. And so, to help starting teams but also help experienced teams to learn about their lacks in cooperation and to shift teamwork level above. Method: We used the method of literature retrieval from books, articles and researches. Results: It is very hard task to define ideal teamwork, we would not find same two teams in the world and therefore each team suits something...

Here Be Dragons: voorgeschiedenis en ontstaan van Adventure Games

NARCIS (Netherlands)

Veugen, Connie

2004-01-01

The article traces the history of adventure games from the birth of the fantasy genre in William Morris' work and the origins of the Kriegspiel, through Tolkien's fantasy world and Dungeons and Dragons to the early text adventures and the first graphical adventures.

Adventure tourists in Pretoria, South Africa: A demographic profile

Directory of Open Access Journals (Sweden)

MJ Lötter

2014-01-01

Full Text Available Adventure activities and experiences constantly evolve because individuals, motives, behaviours, and experiences differ and change over time. In order to assist adventure tourism companies to promote and sell specific activities and experiences that will meet the specific needs and wants of their identified target markets, this paper focuses on the demographic profile of adventure tourists who used the products/services of adventure tourism companies within Pretoria, South Africa. The realised sample was 234, providing a 93.6% response rate. The research instrument used was a self-completing questionnaire. Based on the results, these adventure tourists were Afrikaans speaking individuals between the ages of twenty-eight and forty-nine years. Their households consisted of two to four people and there were generally two income earners per household. This study established that there is a need for further researching of comprehensive adventure tourist profiles.

Learning in Action and Adventure Sports

Science.gov (United States)

Ellmer, Eva; Rynne, Steven

2016-01-01

The exponential growth in action and adventure sport (e.g. snowboarding, bicycle motorcross (BMX), surfing, parkour) participation over the past two decades has been showcased in world championship events and the inclusion in Olympic programs. Yet, by virtue of their alternative, escapist and/or adventure-based origins, these sports do not fully…

Adventures in Manipulation

Science.gov (United States)

Christensen, Bonniejean

1971-01-01

Objects to an alleged misrepresentation and inaccurate presentation of a J. R. R. Tolkien quotation in "Adventures in Reading" (Harcourt, Brace & World, 1969), a ninth grade literature anthology. (RD)

Analysis of supply adventure tourism in the South Bohemian Region

OpenAIRE

Klečacká, Simona

2009-01-01

The thesis, entitled "Analysis of supply adventure tourism in the South Bohemian Region" is to describe and analyze the options and instruments of tourism in selected destination. Work processes typology adventure tourism and also defines key terms related to this topic. It then focuses on identifying different types of adventure tourism, cooperation in the design of an appropriate design and implementation of a new product in the field of adventure tourism.

ADVENTURE TOURISM IN THE SURVEYED POLISH ADVENTURE TOURISTS’ OPINION – OUTLINE OF THE PROBLEM

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Ewa Cieślik

2014-12-01

Full Text Available Tourism is a kind of human activity, which has the ability to simultaneously satisfy a wide human needs’ range and develop people’s personality. Adventure tourism term is a type of tourism able to fulfill these types of human needs. The aim of the study was to know the Polish tourists opinion about the adventure tourism in Poland. The study involved 50 people, taking into account their gender, age, education and occupational status. The research tool was a survey questionnaire. The study indicated that it is not a popular form of tourism in Poland. Its proponents, the information about places and facilities derive mainly from the Internet. The most popular forms are trekking, tramping, caves exploration, paintball, windsurfing, bungejumping and rafting. Rather average possibility of practicing the adventure tourism in Poland is associated with multitude barriers, mainly financial investments, lack of free time, as well as fear and general fear of some of its forms.

Adventure tourism in South Africa: Challenges and prospects

OpenAIRE

Giddy, Julia Kathryn

2016-01-01

There is great potential for the development of adventure tourism in Southern Africa for a number of reasons. One is the variety of landscapes provided by South Africa's natural environment that are suitable for adventure tourism activities, many of which remain relatively pristine. In addition, the development of adventure tourism has significant potential to uplift local communities through local economic development strategies due to the relatively low capital needed to establish many acti...

The adventure of numbers

CERN Document Server

Godefroy, Gilles

2004-01-01

Numbers are fascinating. The fascination begins in childhood, when we first learn to count. It continues as we learn arithmetic, algebra, geometry, and so on. Eventually, we learn that numbers not only help us to measure the world, but also to understand it and, to some extent, to control it. In The Adventure of Numbers, Gilles Godefroy follows the thread of our expanding understanding of numbers to lead us through the history of mathematics. His goal is to share the joy of discovering and understanding this great adventure of the mind. The development of mathematics has been punctuated by a n

ADVENTURE TOURISM AN INSUFFICENTLY EXPLOITED OPPORTUNITY IN BIHOR COUNTY, ROMANIA

Directory of Open Access Journals (Sweden)

Anamaria Liana LĂZURAN (GIURĂU

2014-06-01

Full Text Available The routine of everyday life, the stifling society, the desire of novel and unexpected alongside the unlimited access to information got the modern man on the threshold of a new experience: adventure. Within this context in the tourism industry one type of tourism seems to gain more and more followers: adventure tourism. The adventure tourism is a nature-based tourism involving challenging outdoors activities with a great potential of thrill and excitement. Thus, this paper aims to emphasise the potential for adventure tourism in Bihor County by highlighting the areas where activities related to adventure tourism are developed and to propose new itineraries.

The safety experience of New Zealand adventure tourism operators.

Science.gov (United States)

Bentley, Tim A; Page, Stephen; Walker, Linda

2004-01-01

This survey examined parameters of the New Zealand adventure tourism industry client injury risk. The research also sought to establish priorities for intervention to reduce adventure tourism risk, and identify client injury control measures currently in place (or absent) in the New Zealand adventure tourism industry, with a view to establishing guidelines for the development of effective adventure tourism safety management systems. This 2003 survey builds upon an exploratory study of New Zealand adventure tourism safety conducted by us during 1999. A postal questionnaire was used to survey all identifiable New Zealand adventure tourism operators. The questionnaire asked respondents about their recorded client injury experience, perceptions of client injury risk factors, safety management practices, and barriers to safety. Some 27 adventure tourism activities were represented among the responding sample (n=96). The highest client injury risk was reported in the snow sports, bungee jumping and horse riding sectors, although serious underreporting of minor injuries was evident across the industry. Slips, trips and falls (STF) were the major client injury mechanisms, and a range of risk factors for client injuries were identified. Safety management measures were inconsistently applied across the industry. The industry should consider the implications of poor injury reporting standards and safety management practices generally. Specifically, the industry should consider risk management that focuses on minor (e.g., STF) as well as catastrophic events.

Significant profile differences among male and female adventure tourists in Pretoria, South Africa

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Melissa Jeanette Lötter

2014-01-01

Full Text Available Different adventure activities/experiences evolve because individuals, their motives, behaviours, and experiences differ and change over time. This notion illustrates the broad nature of adventure tourism and its links with other forms of tourism. In turn, adventure tourism companies are compelled to promote/sell an array of activities/experiences to a diverse range of markets as novel and exclusive experiences to facilitate the growth of adventure holidays (Swarbrooke et al., 2003. To assist adventure tourism companies in achieving effective marketing strategies, the study’s objective is to identify significant sociopsychological profile differences among male and female adventure tourists in Pretoria, South Africa. Furthermore, to facilitate the comparison of adventure tourists’ profiles, an equal number of respondents were male (117 and female (117, which provided a 93.6% response rate. In comparison to female respondents, male respondents prefer winter as a season to participate in hard/high-risk adventure activities when they are with or without their family, and they participate in adventure activities for travelling and socialising purposes. Whereas, female respondents predominantly regard scuba-diving, abseiling, and helicopter flights as a hard/high-risk adventure activity, although these activities are generally regarded by the overall sample as being soft/low-risk adventure activities. Furthermore, even though females’ participation in adventure activities is sponsored, they did not participate or only participated in adventure activities once over the past year due to fear/risk and/or lack of skill. This study established that there is a need to further research adventure tourists’ profiles before it could be equally accepted and interpreted.

Adventure and Extreme Sports.

Science.gov (United States)

Gomez, Andrew Thomas; Rao, Ashwin

2016-03-01

Adventure and extreme sports often involve unpredictable and inhospitable environments, high velocities, and stunts. These activities vary widely and include sports like BASE jumping, snowboarding, kayaking, and surfing. Increasing interest and participation in adventure and extreme sports warrants understanding by clinicians to facilitate prevention, identification, and treatment of injuries unique to each sport. This article covers alpine skiing and snowboarding, skateboarding, surfing, bungee jumping, BASE jumping, and whitewater sports with emphasis on epidemiology, demographics, general injury mechanisms, specific injuries, chronic injuries, fatality data, and prevention. Overall, most injuries are related to overuse, trauma, and environmental or microbial exposure. Copyright © 2016 Elsevier Inc. All rights reserved.

Our Heroic Adventure: Creating a Personal Mythology

Science.gov (United States)

Rubin, Lawrence C.

2009-01-01

Utilizing Joseph Campbell's concept of the hero's adventure, this article provides a technique through which clients can story their lives and challenges as an unfolding personal myth or epic adventure. The use of personal narrative and storytelling has found efficacy in the counseling field and, as such, forms a useful foundation for clinical…

Migration as Adventure

DEFF Research Database (Denmark)

Olwig, Karen Fog

2018-01-01

Narratives of adventure constitute a well-established convention of describing travel experiences, yet the significance of this narrative genre in individuals’ accounts of their migration and life abroad has been little investigated. Drawing on Simmel and Bakhtin, among others, this article...

How safe is adventure tourism in New Zealand? An exploratory analysis.

Science.gov (United States)

Bentley, T; Page, S; Meyer, D; Chalmers, D; Laird, I

2001-08-01

The paper reports findings from a multidisciplinary programme of research, the major aims of which were to determine the nature and extent of the New Zealand adventure tourism injury problem. Analysis of hospital discharge and mortality data for a 15-year period identified adventure tourism-related activities as contributing to approximately 20% of overseas visitor injuries, and 22% of fatalities. Activities that commonly involve independent-unguided adventure tourism, notably mountaineering, skiing and tramping, contributed most to injury and fatality incidence. Horse riding and cycling activities were identified from hospital discharge data and adventure tourism operators' reported client injury-incidence, as the commercial adventure tourism activities most frequently involved in client injuries. Falls were the most common injury events, and a range of client, equipment, environmental and organisational risk factors were identified. Possible interventions to reduce injury risk among overseas and domestic adventure tourists are discussed.

The Implementation of an Integrative Model of Adventure-Based Counseling and Adlerian Play Therapy Value-Based Taught by Parents to Children to Increase Adjustment Ability of Preschool Children

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Rita Eka Izzaty

2016-11-01

Full Text Available This study was conducted for two reasons. First, pre-school age is the foundation for the subsequent development. Second, the previous research findings show that there are behavioral problems which affect the development of subsequent development. This study aims to increase children’s social ability by employing An Integrative Model of Adventure-Based Counseling and Adlerian Play Therapy, a counseling model emphasizing the importance of play providing opportunity for children to express their feelings in natural situation and insight toward personality and environment by modifying teaching cultural values by parents to children. This study employed an action study. The prior data collection techniques were conducting literary study, surveying on cultural values taught, and selecting a counseling model. The subjects were four preschool children (4-6 years old with behavioral problems. The study was conducted in 2 cycles with several steps: planning, action, evaluation, and reflection. The finding of this research shows that an Integrative Model of Adventure-Based Counseling and Adlerian Play Therapy can increase children social ability and decrease non adaptive behavior. The reflection of employing counseling model modified with cultural values taught by parents to children is when using this model, counselors truly examine the duration of the implementation, the children’s condition, the counselors’ condition, the type of play, and the purpose of each steps which must be detailed.

Promoting Resiliency in Adolescent Girls through Adventure Programming

Science.gov (United States)

Whittington, Anja; Aspelmeier, Jeffery E.; Budbill, Nadine W.

2016-01-01

This study examined whether participation in an adventure program increased the resiliency of adolescent girls. Eighty-seven girls who participated in Dirt Divas, a non-profit, adventure program, completed the Resiliency Scale for Children and Adolescents® before and after their experience. Means-comparison tests for within-subjects designs were…

Adventure Tourism Benchmark – Analyzing the Case of Suesca, Cundinamarca

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Juan Felipe Tsao Borrero

2012-11-01

Full Text Available Adventure tourism is a growing sector within the tourism industry and understanding its dynamics is fundamental for adventure tourism destinations and their local authorities. Destination benchmarking is a strong tool to identify the performance of tourism services offered at the destination in order to design appropriate policies to improve its competitiveness. The benchmarking study of Suesca, an adventure tourism destination in Colombia, helps to identify the gaps compared with successful adventure tourism destinations around the world, and provides valuable information to local policy-makers on the features to be improved. The lack of available information to tourists and financial facilities hinders the capability of Suesca to improve its competitiveness.

Newton's laws through a science adventure

OpenAIRE

Šuštar, Sara

2013-01-01

The main purpose of my diploma thesis is to create a scientific adventure based on the Newton's laws. My aim has been to introduce this topic to the kids in elementary school as well as the general public. That is why the adventure will take place in the House of Experiments. The first part is dedicated to theory and various experiments, which lead to deeper understanding of the laws. I implemented experiments on rollerblades, such as free movement, movement with the help of springs which wer...

Outdoor Recreation and Adventure Tourism: Unique but Allied Industries

Science.gov (United States)

Bailey, Andrew W.; Kang, H. K.; Lewis, T. Grant

2017-01-01

Outdoor recreation and adventure tourism are overlapping industries serving similar clientele. While descriptive marketing research exists for both industries (George Washington University School of Business [GW], Adventure Travel Trade Association [ATTA], & Xola Consulting [XC], 2010; Outdoor Foundation [OF], 2014), there is no clear…

Participating in Paintball: Adventure or extreme sport?

Directory of Open Access Journals (Sweden)

Dewald Venter

2014-01-01

Full Text Available According to Jessica (2012 paintball is recognised as one of the world's most exciting outdoor participation sports. Paintball is played in over 104 countries by millions of men and women of all ages and lifestyles. Whether homemakers or high-school students, professionals or retirees, all paintball players share in common a love for adventure and a strong competitive spirit. Some confusion exists in industry and amongst players on whether paintball is and adventure or extreme sport as well as terminologies used. The article serves to analyse and clarify the unique terminologies used in paintball and debate classification of paintball as either an adventure or extreme sport. A detailed description of equipment used, player categories as well as formats that are employed are discussed so as to elucidate for readers who are unfamiliar with paintball.

ADVENTURE TOURISM AN INSUFFICENTLY EXPLOITED OPPORTUNITY IN BIHOR COUNTY, ROMANIA

OpenAIRE

Anamaria Liana LĂZURAN (GIURĂU); Mihaela UNGUREANU

2014-01-01

The routine of everyday life, the stifling society, the desire of novel and unexpected alongside the unlimited access to information got the modern man on the threshold of a new experience: adventure. Within this context in the tourism industry one type of tourism seems to gain more and more followers: adventure tourism. The adventure tourism is a nature-based tourism involving challenging outdoors activities with a great potential of thrill and excitement. Thus, this paper aim...

Adolescent Girls and Body Image: Influence of Outdoor Adventure on Healthy Living

Science.gov (United States)

Barr-Wilson, Susie K.; Roberts, Nina S.

2016-01-01

Outdoor adventure may improve body image. However, minimal research exists on the effect outdoor adventure has on body image in adolescent girls, a demographic continually plagued by negative body image. In response, this exploratory study considered the influence of one outdoor adventure program in the San Francisco Bay Area. Through…

Aging Adventure Athletes Assess Achievements and Alter Aspirations to Maintain Self-Esteem

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Ralf C. Buckley

2018-02-01

Full Text Available Achievements and capabilities influence the self-esteem of skilled adventure athletes. Self-esteem affects individual mental health. Aging commonly reduces adventure capabilities. To avoid loss in self-esteem, aging adventure athletes are forced to adjust their aspirations. Here, I examine this process using participant observation, ethnographic and autoethnographic approaches. The qualitative data for this analysis are derived from 60 years’ experience in outdoor adventure activities, and ∼30,000 person-hours of participant observation. I argue that individuals assess their own capabilities against a set of specific feats. For some activities, successful completion of a specific feat is known as nailing it. The selection of these feats depends on factors such as activity and geographic location, as well as individual experience and peer comparisons. I examine the detailed process using a single feat repeated over a period of decades, the bubble-line kayak run through Lava Falls on the Grand Canyon of the Colorado River. I compare other examples of nail or fail to construct a general framework for self-esteem in aging adventure athletes, with both physical and psychological feedback loops. I also identify two key thresholds, as aging adventure athletes recognize their declining skills. These may apply to aging more broadly, beyond outdoor adventure.

Aging Adventure Athletes Assess Achievements and Alter Aspirations to Maintain Self-Esteem.

Science.gov (United States)

Buckley, Ralf C

2018-01-01

Achievements and capabilities influence the self-esteem of skilled adventure athletes. Self-esteem affects individual mental health. Aging commonly reduces adventure capabilities. To avoid loss in self-esteem, aging adventure athletes are forced to adjust their aspirations. Here, I examine this process using participant observation, ethnographic and autoethnographic approaches. The qualitative data for this analysis are derived from 60 years' experience in outdoor adventure activities, and ∼30,000 person-hours of participant observation. I argue that individuals assess their own capabilities against a set of specific feats. For some activities, successful completion of a specific feat is known as nailing it. The selection of these feats depends on factors such as activity and geographic location, as well as individual experience and peer comparisons. I examine the detailed process using a single feat repeated over a period of decades, the bubble-line kayak run through Lava Falls on the Grand Canyon of the Colorado River. I compare other examples of nail or fail to construct a general framework for self-esteem in aging adventure athletes, with both physical and psychological feedback loops. I also identify two key thresholds, as aging adventure athletes recognize their declining skills. These may apply to aging more broadly, beyond outdoor adventure.

The Eustress Paradigm: A Strategy for Decreasing Stress in Wilderness Adventure Programming.

Science.gov (United States)

Estrellas, Anjanette

This essay proposes that stress has been misused in traditional adventure education and presents a new model of risk taking based on the literature on stress and feminist perspectives in adventure education. Proponents of the traditional adventure perspective state that the intentional use of stress is central to the change process in wilderness…

Arduino adventures escape from Gemini station

CERN Document Server

Kelly, James Floyd

2013-01-01

Arduino Adventures: Escape from Gemini Station provides a fun introduction to the Arduino microcontroller by putting you (the reader) into the action of a science fiction adventure story.  You'll find yourself following along as Cade and Elle explore Gemini Station-an orbiting museum dedicated to preserving and sharing technology throughout the centuries. Trouble ensues. The station is evacuated, including Cade and Elle's class that was visiting the station on a field trip. Cade and Elle don't make it aboard their shuttle and are trapped on the station along with a friendly artificial intellig

Improving student understanding in web programming material through multimedia adventure games

Science.gov (United States)

Fitriasari, N. S.; Ashiddiqi, M. F.; Nurdin, E. A.

2018-05-01

This study aims to make multimedia adventure games and find out the improvement of learners’ understanding after being given treatment of using multimedia adventure game in learning Web Programming. Participants of this study are students of class X (ten) in one of the Vocational Schools (SMK) in Indonesia. The material of web programming is a material that difficult enough to be understood by the participant therefore needed tools to facilitate the participants to understand the material. Solutions offered in this study is by using multimedia adventures game. Multimedia has been created using Construct2 and measured understood with method Non-equivalent Control Group Design. Pre-test and post-test has given to learners who received treatment using the multimedia adventure showed increase in understanding web programming material.

Understanding Action and Adventure Sports Participation-An Ecological Dynamics Perspective.

Science.gov (United States)

Immonen, Tuomas; Brymer, Eric; Orth, Dominic; Davids, Keith; Feletti, Francesco; Liukkonen, Jarmo; Jaakkola, Timo

2017-12-01

Previous research has considered action and adventure sports using a variety of associated terms and definitions which has led to confusing discourse and contradictory research findings. Traditional narratives have typically considered participation exclusively as the pastime of young people with abnormal characteristics or personalities having unhealthy and pathological tendencies to take risks because of the need for thrill, excitement or an adrenaline 'rush'. Conversely, recent research has linked even the most extreme forms of action and adventure sports to positive physical and psychological health and well-being outcomes. Here, we argue that traditional frameworks have led to definitions, which, as currently used by researchers, ignore key elements constituting the essential merit of these sports. In this paper, we suggest that this lack of conceptual clarity in understanding cognitions, perception and action in action and adventure sports requires a comprehensive explanatory framework, ecological dynamics which considers person-environment interactions from a multidisciplinary perspective. Action and adventure sports can be fundamentally conceptualized as activities which flourish through creative exploration of novel movement experiences, continuously expanding and evolving beyond predetermined environmental, physical, psychological or sociocultural boundaries. The outcome is the emergence of a rich variety of participation styles and philosophical differences within and across activities. The purpose of this paper is twofold: (a) to point out some limitations of existing research on action and adventure sports; (b) based on key ideas from emerging research and an ecological dynamics approach, to propose a holistic multidisciplinary model for defining and understanding action and adventure sports that may better guide future research and practical implications.

Going Pro: Point of View Cameras in Adventure Sports Research

Science.gov (United States)

French, Graham

2016-01-01

The role of the adventure sports coach was first identified by Collins and Collins (2012) who suggested that the sports coaching process is significantly different in an adventurous context. Whilst there is a growing body of literature surrounding coaching pedagogy (Hay, Dickens, Crudginton, & Engstrom, 2012), investigation of coaching…

Mitigating Litigation for Adventure Recreation Operators: The Ski Safety Act

Science.gov (United States)

Brgoch, Shea; Lower, Leeann M.

2017-01-01

Adventure tourism is a rapidly growing segment of the tourism industry, which can be regarded as specific activities that are alluring for their uncertain and potentially dangerous outcomes. Risk-taking attitudes and behaviors may be common among adventure recreationists and increase the potential for litigation against recreation operators. In…

Internal Radiation Therapy for Cancer

Science.gov (United States)

When getting internal radiation therapy, a source of radiation is put inside your body, in either liquid or solid form. It can be used treat different kinds of cancer, including thyroid, head and neck, breast, cervix, prostate, and eye. Learn more about how what to expect when getting internal radiation therapy.

Adventurous activities, embodiment and nature: spiritual, sensual and sustainable? Embodying environmental justice

Directory of Open Access Journals (Sweden)

Barbara Humberstone

2013-09-01

Full Text Available This paper examines research on adventurous physical activities in nature from the perspective of the sentient body. Drawing upon ethnographic and autoethnographic research, I examine what has been termed 'peak' happenings or 'flow' which many who practise adventurous activities claim to experience through their whole body when in the 'zone'. I consider the concept of 'edgework', voluntary risk-taking, and insightful mobile and social understanding of the relationships between body, emotions and the elements, where the adventurous activity is experienced and interpreted as oneness with nature or expressed as 'spiritual' not only in high but also low risk nature-based sport. I then consider if and in what ways these knowledges may bring about greater understanding and action in relation to social and environmental justice. I argue that adventurous activities/nature-based sport may provide processes and practices that are alternative or complementary to traditional sporting 'body techniques' or 'body pedagogics'. I suggest that modern embodied adventurous practices in nature challenge dominant narratives of body/mind separation and potentially provide a pedagogic process fostering kinetic empathy. Finally I draw attention to the paradox of (re-presenting sensorial experiences of sport in nature and ask for consideration on how we interconnect with the environment when we participate in adventureous nature-based sports.

Adventure in a Bun.

Science.gov (United States)

Loynes, Chris

1998-01-01

Aspects of outdoor adventure education such as sport and risk are increasingly commercialized, whereas the core value of connection--to community, the environment, or other people--is being lost. A shift from providing challenge to encouraging exploration may enable programs emphasizing connection to find a home in the "third sector"…

Outdoor Program Models: Placing Cooperative Adventure and Adventure Education Models on the Continuum.

Science.gov (United States)

Guthrie, Steven P.

In two articles on outdoor programming models, Watters distinguished four models on a continuum ranging from the common adventure model, with minimal organizational structure and leadership control, to the guide service model, in which leaders are autocratic and trips are highly structured. Club programs and instructional programs were in between,…

Risk Stratification for Athletes and Adventurers in High-Altitude Environments: Recommendations for Preparticipation Evaluation.

Science.gov (United States)

Campbell, Aaron D; McIntosh, Scott E; Nyberg, Andy; Powell, Amy P; Schoene, Robert B; Hackett, Peter

2015-12-01

High-altitude athletes and adventurers face a number of environmental and medical risks. Clinicians often advise participants or guiding agencies before or during these experiences. Preparticipation evaluation (PPE) has the potential to reduce risk of high-altitude illnesses in athletes and adventurers. Specific conditions susceptible to high-altitude exacerbation also important to evaluate include cardiovascular and lung diseases. Recommendations by which to counsel individuals before participation in altitude sports and adventures are few and of limited focus. We reviewed the literature, collected expert opinion, and augmented principles of a traditional sport PPE to accommodate the high-altitude wilderness athlete/adventurer. We present our findings with specific recommendations on risk stratification during a PPE for the high-altitude athlete/adventurer. Copyright © 2015. Published by Elsevier Inc.

International Occupational Therapy Research Priorities.

Science.gov (United States)

Mackenzie, Lynette; Coppola, Susan; Alvarez, Liliana; Cibule, Lolita; Maltsev, Sergey; Loh, Siew Yim; Mlambo, Tecla; Ikiugu, Moses N; Pihlar, Zdenka; Sriphetcharawut, Sarinya; Baptiste, Sue; Ledgerd, Richard

2017-04-01

Occupational therapy is a global profession represented by the World Federation of Occupational Therapists (WFOT). International research priorities are needed for strategic guidance on global occupational therapy practice. The objective of this study was to develop international research priorities to reflect global occupational therapy practice. A Delphi study using three rounds of electronic surveys, distributed to WFOT member organizations and WFOT accredited universities, was conducted. Data were analyzed after each round, and priorities were presented for rating and ranking in order of importance. Forty-six (53%) out of 87 WFOT member countries participated in the Delphi process. Eight research priorities were confirmed by the final electronic survey round. Differences were observed in rankings given by member organizations and university respondents. Despite attrition at Round 3, the final research priorities will help to focus research efforts in occupational therapy globally. Follow-up research is needed to determine how the research priorities are being adopted internationally.

Psychological implications of outdoor adventure model of education

Directory of Open Access Journals (Sweden)

Paulina Kida

2017-07-01

Full Text Available The article is a synthetic analysis of the Outdoor Adventure Education model in the context of three elementary components: the environment – in relation to the theory of space from the perspective of sociological and pedagogical theory of space; personal perspective and growth as well as social development – in relation to psychological phenomena that accompany the individual and group involved in the process of Outdoor Adventure Education. The aim is to present how these processes determine the effects of education and what personalities’ elements are involved.

The Romance of Risk: Adventure's Incorporation in Risk Society

Science.gov (United States)

Bell, Martha

2017-01-01

Adventure has outgrown its use as a metaphor and motive for educational journeys into the cultural outdoors. Self-reliance cannot counter the mechanisation of everyday life. "Adventure" is produced and serviced by the very people who felt its worth to their own individualisation and now advance its professionalisation for their own…

Modeling Internal Radiation Therapy

NARCIS (Netherlands)

van den Broek, Egon; Schouten, Theo E.; Pellegrini, M.; Fred, A.; Filipe, J.; Gamboa, H.

2011-01-01

A new technique is described to model (internal) radiation therapy. It is founded on morphological processing, in particular distance transforms. Its formal basis is presented as well as its implementation via the Fast Exact Euclidean Distance (FEED) transform. Its use for all variations of internal

The adventure of atom. Vol.1

International Nuclear Information System (INIS)

La Gorce, P.M. de; Bacher, P.; Bourgeois, J.; Bussac, J.; Cauquais, C.; Gauvenet, A.; Goldschmidt, B.; Le Baut, Y.; Mezin, M.

1992-01-01

In the first volume on the ambiguous adventure of atom, the authors present the history of atom conquest with the discoveries of natural and artificial radioactivity and chain reactions, before to explain the first military uses

Nuclear deterrence - The French nuclear adventure - The cockerel's spurs

International Nuclear Information System (INIS)

Valensi, Edouard

2013-01-01

This book reveals the secrets of the French strike force: the formidable adventure which provided France with first ranking strategic forces, the incredible fight given by Europe and the European Commission states to prohibit France from acquiring nuclear weapons, the US ambiguous game of accompanying France in her nuclear adventure in order to better monitor her, the core of deterrence with its doctrine of use, and for the future, the measures which will make French deterrence a decisive tool for worldwide peace

Matołek Broda. Creative and publishing adventures

Directory of Open Access Journals (Sweden)

Justyna Staroń

2016-03-01

Full Text Available The article discusses issues related to the creative process and the editorial fate of The Adventures of Matołek the Billy-Goat by Kornel Makuszyński. It contains collected informations on the appearance of an idea for a book-comic for children (as told by Makuszyński’s wife – Janina, Marian Walentynowicz, Jan Gebethner, through the actual process of writing, the first edition and post-war issue. Also it discusses drawings from The 120 adventures of Matołek the Billy-Goat which sometimes differ quite significantly depending on the edition.

A constraints-based approach to the acquisition of expertise in outdoor adventure sports

NARCIS (Netherlands)

Davids, Keith; Brymer, Eric; Seifert, Ludovic; Orth, Dominic

2013-01-01

A constraints-based framework enables a new understanding of expertise in outdoor adventure sports by considering performer-environment couplings through emergent and self-organizing behaviours in relation to interacting constraints. Expert adventure athletes, conceptualized as complex, dynamical

Effects of a Developmental Adventure on the Self-Esteem of College Students

Science.gov (United States)

Paquette, Linda; Brassard, Audrey; Guérin, Audrey; Fortin-Chevalier, Justine; Tanguay-Beaudoin, Laurence

2014-01-01

This study examines the effects of outdoor developmental adventure programming (ODA) on college students' self-esteem. Although some previous studies have shown that outdoor adventure programming has positive effects on self-esteem, others did not find any effect. A quasi-experimental study was conducted over 5 months, which included two pretests…

Stakeholders willingness to apply sustainable adventure tourism indicators: a case of Waterval Boven in South Africa

Directory of Open Access Journals (Sweden)

NN Tshipala

2014-01-01

Full Text Available In South Africa and across the globe, the development of adventure tourism industry has resulted in a multitude of different types of activities, destinations, risks, impacts and unsustainable practices. The development of adventure tourism in many destinations has boosted many economies across rural communities and countries. The added benefits of developing adventure tourism in a sustainable manner include the promotion of responsible investment, infrastructure development and a host of other positive economic, social and environmental impacts. This study investigates the stakeholders will to utilise sustainable adventure tourism indicators from residents, tourists, business owners and government employees at Waterval Boven if made available. Descriptive statistics were presented; Cronbach Alpha and Chi-square tests were also applied. In general, the respondents perceived the indicators positively and felt they could assist in the sustainable development of adventure tourism. The study contributes towards the development of sustainable adventure tourism destinations that can make a significant contribution towards poverty alleviation by maximising social and economic benefits for locals, enhancing cultural heritage and reducing any negative impacts on the environment.

The Adventurous Gene

DEFF Research Database (Denmark)

Blomkvist, Katarina; Cantwell, John A.; Kappen, Philip

2014-01-01

In this paper we explore the notion of imprinting in the multinational corporation (MNC), specifically how during the brief period when foreign subsidiaries turn into technologically advanced units they are influenced by the technological activities carried out at headquarters and home country...... units. We hypothesize and empirically show that during that period of transition the degree of adventurousness or explorative intensity of home country units is replicated and has a long-lasting effect on the type of technological work carried out by the foreign subsidiaries. The results suggest...

A marketing plan for the ice cream brand Max Adventures in food service

OpenAIRE

Carbó, Marina Cercós

2013-01-01

A Work Project, presented as part of the requirements for the Award of a Masters Degree in Management from the NOVA – School of Business and Economics This project consists on developing a marketing plan in the Spanish market for the ice cream brand Max Adventures in the food service sector. The objective of the plan is to increase current level of sales and distribution. For this reason an external and internal audit is done in order to understand the context, observe what competitors are...

The natural-geographical basics for the development of the adventure tourism in Serbia

Directory of Open Access Journals (Sweden)

Spalević Aleksandra

2011-01-01

Full Text Available Adventure tourism represents traveling motivated by the wish to be in the nature. It includes both physical and cultural interaction between the nature and a tourist. The concept of “adventure” includes the wish of a guest for unusual activities and experience. This is also followed by excitement. The natural and tourist potentials of Serbia are analyzed in this work. The types of adventure tourism, for which there are favorable conditions in our country, are sorted out. Among different adventure activities the most important are: hiking, speleo tourism, rafting, cannoning, paragliding and mountain biking. Nevertheless, due to many problems this branch of tourism is undeveloped. In the analysis of the tourist space of Serbia, the beginning point is the mountain documents from the section about the development of tourism. In accordance with them and based on natural and anthropogenic resources and the potentials of Serbia, the possible ways of development of adventure tourism in Serbia are defined. The aim of this work is to draw attention to adventure tourism of Serbia and to point out the possibilities of its development based on the characteristics of the natural values. It also aims to suggest the potential areas-centers of development of this tourist branch.

Nursing care update: Internal radiation therapy

International Nuclear Information System (INIS)

Lowdermilk, D.L.

1990-01-01

Internal radiation therapy has been used in treating gynecological cancers for over 100 years. A variety of radioactive sources are currently used alone and in combination with other cancer treatments. Nurses need to be able to provide safe, comprehensive care to patients receiving internal radiation therapy while using precautions to keep the risks of exposure to a minimum. This article discusses current trends and issues related to such treatment for gynecological cancers.20 references

A History of Adventure in Children's Literature

DEFF Research Database (Denmark)

McCausland, Elly

2017-01-01

with popular medievalism and the figure of the bold chivalric knight intersected with bourgeois forms of venture capitalism; the resulting children’s adventure narratives attempt to negotiate and even combine these two very different forms of risk-taking. Next, I will explore the rise of fantasy literature......This project will examine representations of risk in children’s literature from the mid-nineteenth century to the present day. It will explore how issues of risk and trust have been mediated through children’s narratives, and how the adventurous child has served, and continues to serve...... for children following the Second World War. There are numerous overviews of trends within children’s literature during this period, but little exists that links these trends with their immediate sociocultural context and with changing attitudes towards childhood during the aftermath of the war...

Adventures in Python

CERN Document Server

Richardson, Craig

2015-01-01

The complete beginner's guide to Python, for young people whowant to start today Adventures in Python is designed for 11-to 15-year oldswho want to teach themselves Python programming, but don't knowwhere to start. Even if you have no programming experience at all,this easy to follow format and clear, simple instruction will getyou up and running quickly. The book walks you through nineprojects that teach you the fundamentals of programming in general,and Python in particular, gradually building your skills until youhave the confidence and ability to tackle your own projects. Videoclips accom

Adventure Counseling as an Adjunct to Group Counseling in Hospital and Clinical Settings

Science.gov (United States)

Gillen, Mark C.; Balkin, Richard S.

2006-01-01

Adventure counseling has been thought of as a highly specialized application of group counseling skills in a wilderness environment. In fact, adventure counseling is based on a developmental theory of group, can be useful for a variety of clients, and can be thoughtfully integrated into clinical and hospital settings. This article describes the…

Adventures in Evaluation: Reviewing a CD-ROM Based Adventure Game Designed for Young People Recovering from Psychosis

Science.gov (United States)

Shrimpton, Bradley; Hurworth, Rosalind

2005-01-01

Recently the Centre for Program Evaluation (CPE) at the University of Melbourne was approached by a mental health agency to undertake the unique and challenging task of evaluating a prototype CD-ROM based adventure game designed for young people recovering from psychosis. This unusual and inventive game, titled Pogo's Pledge, used…

An International Polar Year Adventure in the Arctic

Science.gov (United States)

Wartes, D.

2008-12-01

Native students in the UA system who participated in RAHI are nearly twice as likely to earn a bachelor's degree, than those who did not attend RAHI. The past two summers, in celebration of the International Polar Year, in collaboration with Ilisagvik College, at the completion of the traditional RAHI program, ten RAHI students flew to Barrow for an additional two weeks of study. Five students participated in an archaeological dig and five students performed research with the Barrow Arctic Science Consortium scientists studying climate change. And another student was the Alaskan delegate to the Students on Ice, a 2-week ship-based adventure in northern Canada. In addition, ten students from Greenland visited the program, with plans to more fully participate next summer. This added dimension to the program has proved successful, allowing the students to compare and contrast between their own countries and indigenous perspectives. Global warming was an issue that was hotly debated, as its effects are so evident in the Polar Regions. In the Arctic, one's life is directly tied to the ice and snow. As the ice disappears and/or changes, the Indigenous people have to adapt. RAHI would like to share with you some of the results of this past summer's IPY activities.

Outdoor Education Opportunities for Middle School Students: Academic and Social Impacts of Adventure Programs

Science.gov (United States)

Gordon, Lisa

2011-01-01

This study examines components of outdoor adventure programs for middle school students, using a school with a successful program as a model. Outdoor education is often left out of these years for financial and safety reasons, however the benefits of adventure programs are both measurable and profound to self-concept, confidence, identity growth,…

The Tipping Point and the Adventure Advantage.

Science.gov (United States)

Prouty, Dick

1998-01-01

Insights from chaos theory--the interconnectedness of everything, nonlinear cause and effect, leverage and the "tipping point," and the importance of aligning interventions within a system--are applied to social action and illustrated via the role of adventure education in school and community interventions in the Brattleboro (Vermont) Leadership…

Wilderness medicine: strategies for provision of medical support for adventure racing.

Science.gov (United States)

Townes, David A

2005-01-01

In adventure racing, or multisporting, athletes perform multiple disciplines over a course in rugged, often remote, wilderness terrain. Disciplines may include, but are not limited to, hiking, trail running, mountain biking, caving, technical climbing, fixed-line mountaineering, flat- and white-water boating, and orienteering. While sprint races may be as short as 6 hours, expedition-length adventure races last a minimum of 36 hours up to 10 days or more and may cover hundreds of kilometres. Over the past decade, adventure racing has grown in popularity throughout the world with increasing numbers of events and participants each year. The provision of on-site medical care during these events is essential to ensure the health and safety of the athletes and thus the success of the sport. At present, there are no formal guidelines and a relatively small amount of literature to assist in the development of medical support plans for these events. This article provides an introduction to the provision of medical support for adventure races. Since a wide variety of illness and injury occur during these events, the medical support plan should provide for proper personnel, equipment and supplies to provide care for a wide range of illness and injury. Foot-related problems are the most common reasons for athletes to require medical attention during these events. This article also highlights some of the controversies involved in the provision of medical support for these events. Suggested penalties for acceptance of medical care during the event and strategies for removal of an athlete from the event for medical reasons are offered. In addition, some of the challenges involved in the provision of medical support, including communication, logistics and liability are discussed. This information should prove useful for medical directors of future, similar events. Because of their extreme nature, expedition-length adventure races represent a new and unique area of wilderness and

The Universe Adventure - The Beginnings of Cosmology

Science.gov (United States)

The Universe Adventure [ next ] [ home ] Go The Beginnings of Cosmology Since the beginning of of stars? What do the stars tell us about the future? Where did the Universe come from? Cosmology is will introduce you to Cosmology and the study of the structure, history, and fate of the Universe. In

Counseling for the Wilderness Athlete and Adventurer During a Preparticipation Evaluation for Preparation, Safety, and Injury Prevention.

Science.gov (United States)

Young, Justin Mark J; Campbell, Aaron D; Raastad, Kate K

2015-12-01

Wilderness sports and adventures continue to increase in popularity. Counseling is an essential element of the preparticipation evaluation (PPE) for athletes in traditional sports. This approach can be applied to and augmented for the wilderness athlete and adventurer. The authors reviewed the literature on counseling during PPEs and gathered expert opinion from medical professionals who perform such PPEs for wilderness sports enthusiasts. The objective was to present findings of this review and make recommendations on the counseling component of a wilderness sports/adventure PPE. The counseling component of a PPE for wilderness sports/adventures should take place after a basic medical evaluation, and include a discussion on sport or activity-specific injury prevention, personal health, travel recommendations, and emergency event planning. Counseling should be individualized and thorough, and involve shared decision making. This should take place early enough to allow ample time for the athlete or adventurer to further prepare as needed based on the recommendations. Resources may be recommended for individuals desiring more information on selected topics. Copyright © 2015. Published by Elsevier Inc.

Mythic Frodo and his Predestinate Call to Adventure

Directory of Open Access Journals (Sweden)

Farid Mohammadi

2013-09-01

Full Text Available One of the most interesting aspects of J.R.R. Tolkien’s stories, especially The Lord of the Rings is the presentation of the multidimensional characters; therefore, the complexity of interpretations concerning their actions, motives, and aims will be manifested from the beginning of the story, until the end. Following the study of a mythic hero’s adventure, initiation, and psychological aspects, the present paper focuses on the investigation of Predestinate Call to Adventure. The researcher has benefited the theories of Joseph Campbell, presented in his renowned book The Hero with a Thousand Faces and the supplementary comments of Christopher Vogler. In fact, the researcher’s motivation for the work initiated in this regard is to improve the very few previous attempts studied by others, concerning Frodo Baggins’ role as the main and the most tragic hero of The Lord of the Rings.

Adventures in Raspberry Pi

CERN Document Server

Philbin, Carrie Anne

2015-01-01

Start programming quickly with this super-fun guide to Raspberry Pi Adventures in Raspberry Pi, 2nd Edition includes 9 cool projects that show you how to set up and start developing on your Raspberry Pi. Updated for the release of the Rev 3 board, this second edition covers all the latest features and tells you everything you need to know. Written specifically for 11-15 year-olds, this book uses the wildly successful, Raspberry Pi to explain the fundamentals of computing. You'll have a blast learning basic programming and system administration skills, beginning with the very basics of how to p

Adventures in Celestial Mechanics

CERN Document Server

Szebehely, Victor G

1998-01-01

A fascinating introduction to the basic principles of orbital mechanics. It has been three hundred years since Isaac Newton first formulated laws to explain the orbits of the Moon and the planets of our solar system. In so doing he laid the groundwork for modern science's understanding of the workings of the cosmos and helped pave the way to the age of space exploration. Adventures in Celestial Mechanics offers students an enjoyable way to become acquainted with the basic principles involved in the motions of natural and human-made bodies in space. Packed with examples in which these principle

External and internal radiation therapy: Past and future directions

Directory of Open Access Journals (Sweden)

Sadeghi Mahdi

2010-01-01

Full Text Available Cancer is a leading cause of morbidity and mortality in the modern world. Treatment modalities comprise radiation therapy, surgery, chemotherapy and hormonal therapy. Radiation therapy can be performed by using external or internal radiation therapy. However, each method has its unique properties which undertakes special role in cancer treatment, this question is brought up that: For cancer treatment, whether external radiation therapy is more efficient or internal radiation therapy one? To answer this question, we need to consider principles and structure of individual methods. In this review, principles and application of each method are considered and finally these two methods are compared with each other.

Locating opportunities for outdoor action and adventure recreation ...

African Journals Online (AJOL)

This paper indicates how modern spatial computing technology can be used for developing spatial policy for, and planning of outdoor action and adventure recreation and tourism (OAART). An application was performed in the Western Cape Province of South Africa. The research overviews spatial recreation and tourism ...

The Sweat Lodge Ceremony in Challenge/Adventure Programming.

Science.gov (United States)

Quinn, William J.; Smith, Thomas E.

This paper advocates the potentials of "sweat lodge" rituals for adventure education programs. Historically, rituals and ceremonies have been instrumental in passing major philosophical and sociological paradigms from one generation to the next. However, there is little theory and research about how ritual and ceremony results in the…

The Chemical Adventures of Sherlock Holmes: The Baker Street Burning.

Science.gov (United States)

Waddell, Thomas G.; Rybolt, Thomas R.

1998-01-01

Presents the ninth story in a series of chemical mysteries with emphasis on forensic chemistry, physical properties, and qualitative organic analysis. The mystery centers around the adventures of Sherlock Holmes. (DDR)

Monitoring injury in the New Zealand adventure tourism sector: an operator survey.

Science.gov (United States)

Bentley, Tim A; Page, Stephen; Edwards, Joanna

2008-01-01

Client safety is a major risk management concern for the commercial adventure tourism sector in New Zealand. This study built on previous exploratory analyses of New Zealand adventure tourism safety, including industry surveys conducted by these authors in 1999 and 2003. The aims of the study were to provide a continuation of injury monitoring across the sector through data collected from self-reported injury incidence by industry operators and to compare findings with those from other primary and secondary research studies conducted by the authors. A postal questionnaire was used to survey all identifiable New Zealand adventure tourism operators during 2006. The questionnaire asked respondents about their recorded client injury experience, perceptions of client injury risk factors, and safety management practices. Some 21 adventure tourism activities were represented among the responding sample (n = 127), with most operations being very small in terms of staff numbers, although responding operators catered to nearly 1 million clients in total annually. Highest ranked risk factors for client injury included clients not following instructions; level of client skill, ability, and fitness; and changeable/unpredictable weather conditions. Highest client injury was reported for horse riding, ecotourism, and white water rafting sectors, although serious underreporting of minor injuries was evidenced across the sector. Slips, trips, and falls were the most frequently reported injury mechanism, while safety management measures were inconsistently applied across the sector. The industry should address reporting culture issues and safety management practices generally. Specifically, the industry should consider risk management that focuses on minor (eg, falls) as well as catastrophic events.

The Social System in Outdoor Adventure Education Programs

Science.gov (United States)

Sibthorp, Jim; Jostad, Jeremy

2014-01-01

Many components of the social system interact with one another to produce group-level behavior that determines the functionality of the small group in outdoor adventure education (OAE). This article synthesizes the contemporary literature and theory regarding eight aspects of the OAE social system: (a) Macro Contextual Factors, (b) Student…

The Meaning Associated with the Experience of a Sea Kayaking Adventure among Adults with Visual Impairment

Science.gov (United States)

Nancy Eagan

2004-01-01

What is the meaning associated with participation in an outdoor adventure for a person with a disability? A number of studies have investigated the topic of adventure program outcomes for people with and without disabilities. The author located two studies about kayaking with individuals with disabilities: 1) Siegel Taylor and Evans McGruder (1995) found “subjects...

A Weekend in the Country: The Outdoors, the Earth & Drama Therapy.

Science.gov (United States)

Reed, Chris

1999-01-01

A group of British graduate students in drama and movement therapy spent a weekend outdoors engaging in adventure, dramatic, and creative activities that focused on the symbolism of the Earth and increasing awareness of the self, the environment, and spirituality. (SV)

A Socio-Environmental Case for Skill in Outdoor Adventure

Science.gov (United States)

Mullins, Philip M.

2014-01-01

In response to the crisis of sustainability, this paper revisits understandings of human--environment relations established through skill-based outdoor activities that are used commonly among adventure recreation, education, and tourism. Reconsidering a predominant focus on risk and a persistent tension between technical and environmental…

The effect of adventure-based experiential learning on personal ...

African Journals Online (AJOL)

The purpose of the study was to determine the effectiveness of Adventure-based Experiential Learning (AEL) in developing the personal effectiveness of adolescents. Twenty three adolescents, currently enrolled in a post-matriculation development centre were studied. The study consisted of an experimental (n=12) and ...

Resurgent Military Political Adventurism in West Africa: Implications ...

African Journals Online (AJOL)

The democratization efforts of the 1990s in West Africa appeared to have put paid to military political adventurism which had been the plague of that region since independence in the 1960s. But since the year 2000 there has been a resurgence of military intervention in the politics of some West African states and this calls ...

The Writing Process for "Edutaining" CD-ROM Adventures.

Science.gov (United States)

Mountain, Lee

2000-01-01

Describes a CD-ROM adventure story written by the author to educate her students about the word relationships of synonyms and antonyms. Discusses how this interactive medium put a different twist on each of the stages of the writing process itself. Relates how two students enthusiastically used the program, and were inspired to write one of their…

Integration of professional judgement and decision-making in high-level adventure sports coaching practice.

Science.gov (United States)

Collins, Loel; Collins, Dave

2015-01-01

This study examined the integration of professional judgement and decision-making processes in adventure sports coaching. The study utilised a thematic analysis approach to investigate the decision-making practices of a sample of high-level adventure sports coaches over a series of sessions. Results revealed that, in order to make judgements and decisions in practice, expert coaches employ a range of practical and pedagogic management strategies to create and opportunistically use time for decision-making. These approaches include span of control and time management strategies to facilitate the decision-making process regarding risk management, venue selection, aims, objectives, session content, and differentiation of the coaching process. The implication for coaches, coach education, and accreditation is the recognition and training of the approaches that "create time" for the judgements in practice, namely "creating space to think". The paper concludes by offering a template for a more expertise-focused progression in adventure sports coaching.

The impact of an adventure based experiential learning programme ...

African Journals Online (AJOL)

The aim of this study was to determine the effect of an adventure based experiential learning programme (AEP) in developing the life effectiveness of black high school learners. “Life Effectiveness” reflects the psychological and behavioural aspects of human functioning which determine the proficiency of a person in society.

“Soldiers of paint”: Relationship between leisure adventure combat ...

African Journals Online (AJOL)

Adventure sports tourism has shown consistent growth during the last several decades as a leisure activity that stands as an antithesis of traditional leisure tourism. ... An exploratory factor analysis on the leisure aspects of paintball, positive sport lifestyle, leisure and recreation life domain positive/negative effect and quality ...

Kultuurilaev "Adventure" Tallinna ja Kotka sadamas / Juta Kivimäe

Index Scriptorium Estoniae

Kivimäe, Juta, 1952-

2005-01-01

Eesti kirjanikud, muusikud ja kunstnikud Kotkas kultuuriüritusel "Adventure". Jaan Elkeni kureeritud kolmest kunstinäitusest üldnimega "Tallinn-Kotka. Kaksteist Tallinna kunstnikku Kotkas" (osalejad loetletud), Matti Variku tehtud Lenini monumendist Kotkas, meenutusi eesti kunstnike varasematest Kotka-näitustest

Designing and Building of 3D Adventure Game “Tetuko: Childhood of Ghatotkacha” Using Kinect

Directory of Open Access Journals (Sweden)

Achmad Basuki

2014-06-01

Full Text Available Nowadays, the young people are not interested in the local culture as a “wayang” puppet. This condition threatens the extinction of some of the local culture that should be a mainstay of the industry entering an era of creative industries. On the other hand, theyare more interested in playing computer games as changing of people's lifestyles. It becomes our basic idea to produce a game as a creative product. The genre of this game is fighting-adventure. This game depictures a story of fighting between the baby Tetuko and giant Kala Pracona. The game uses Kinect and 3D platform technology to attract more players to feel their adventures. With Kinect technology, the player can control the character with his gesture. Thus, this game will increase the awareness of young people about the culture of Wayang. Keywords : 3D game, kinect,adventure, local culture, creative industry.

Cardiovascular disease in the Adventures of Sherlock Holmes.

Science.gov (United States)

Ramanan, S V

2001-03-12

The Adventures of Sherlock Holmes by Sir Arthur Conan Doyle contains many incidents of medical interest. While disorders of the cardiovascular system do not play an important role in these tales, there are, nevertheless, some illnesses that invite speculation. Eleven such incidents are reviewed and discussed in light of the times in which they occurred and in light of current medical knowledge.

The Spirit of Adventure and the Art of Creation

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 19; Issue 7. The Spirit of Adventure and the Art of Creation: Camphor to Vitamin B12. Setty Mallikarjuna Babu Subramania Ranganathan. General Article Volume 19 Issue 7 July 2014 pp 593-623 ... Keywords. Camphor; vitamin B12; art of creation.

Decision Making and Risk Management in Adventure Sports Coaching

Science.gov (United States)

Collins, Loel; Collins, Dave

2013-01-01

Adventure sport coaches practice in environments that are dynamic and high in risk, both perceived and actual. The inherent risks associated with these activities, individuals' responses and the optimal exploitation of both combine to make the processes of risk management more complex and hazardous than the traditional sports where risk management…

Adventures in supercomputing: An innovative program for high school teachers

Energy Technology Data Exchange (ETDEWEB)

Oliver, C.E.; Hicks, H.R.; Summers, B.G. [Oak Ridge National Lab., TN (United States); Staten, D.G. [Wartburg Central High School, TN (United States)

1994-12-31

Within the realm of education, seldom does an innovative program become available with the potential to change an educator`s teaching methodology. Adventures in Supercomputing (AiS), sponsored by the U.S. Department of Energy (DOE), is such a program. It is a program for high school teachers that changes the teacher paradigm from a teacher-directed approach of teaching to a student-centered approach. {open_quotes}A student-centered classroom offers better opportunities for development of internal motivation, planning skills, goal setting and perseverance than does the traditional teacher-directed mode{close_quotes}. Not only is the process of teaching changed, but the cross-curricula integration within the AiS materials is remarkable. Written from a teacher`s perspective, this paper will describe the AiS program and its effects on teachers and students, primarily at Wartburg Central High School, in Wartburg, Tennessee. The AiS program in Tennessee is sponsored by Oak Ridge National Laboratory (ORNL).

Is ecotourism an alternative to adventure tourism in El Chaco?

Directory of Open Access Journals (Sweden)

Daniela Polanco

2017-07-01

Full Text Available El Chaco is one of the cantons has excelled in adventure tourism. However, since 2006 this activity has not broken and tourism has been separated from the local development. The objective of the present investigation is to find out the issues that affect the adventure tourism in El Chaco and to propose a new tourism product regarding the zone possibilities. In order to obtain the results, it has been developed a theoretical and methodological investigation focused in interviews and social cartography in Gonzalo Díaz de Pineda and in the cantonal head El Chaco. The main results denote the lack of organization, the high costs and the impacts generated by the construction of the Coca Codo Sinclair hydroelectric power plant. These results make visible the problems and support the suggestion of practicing ecotourism as a new choice of local development in the region.

Professional judgement and decision-making in adventure sports coaching: the role of interaction.

Science.gov (United States)

Collins, Loel; Collins, Dave

2016-01-01

This qualitative study presents the view that coaching practice places demands on the coach's adaptability and flexibility. These requirements for being adaptive and flexible are met through a careful process of professional judgement and decision-making based on context-appropriate bodies of knowledge. Adventure sports coaches were selected for study on the basis that adventure sports create a hyper-dynamic environment in which these features can be examined. Thematic analysis revealed that coaches were generally well informed and practised with respect to the technical aspects of their sporting disciplines. Less positively, however, they often relied on ad hoc contextualisation of generalised theories of coaching practice to respond to the hyper-dynamic environments encountered in adventure sports. We propose that coaching practice reflects the demands of the environment, individual learning needs of the students and the task at hand. Together, these factors outwardly resemble a constraints-led approach but, we suggest, actually reflect manipulation of these parameters from a cognitive rather than an ecological perspective. This process is facilitated by a refined judgement and decision-making process, sophisticated epistemology and an explicit interaction of coaching components.

GoNorth! - An Adventure Learning Case Study

Science.gov (United States)

Porsild, M.; Doering, A.; Pregont, P.

2008-12-01

GoNorth! is an adventure learning series developed at the University of Minnesota in collaboration with NOMADS Online Expeditions. GoNorth! uses real-time experiences of dogsled expeditions on a multimedia saturated website at http://www.PolarHusky.com to motivate and engage millions of K-12 students and teachers. The program is free and research (Doering & Veletsianos, 2007) shows that it can be adopted by any teacher who signs up to use the program. It is currently utilized in 3400+ classrooms across the 50 US States and in 29 countries worldwide. Research (Doering & Veletsianos, 2007; 2008) notes that students working with GoNorth! are excited, motivated, and eager to engage with authentic tasks, solve real-world problems, collaborate with colleagues and experts, and initiate actions in their own community. Our team of educators, scientists and explorers circumnavigate the Arctic traveling by dog team to a new Arctic locale every year. Driven by an environmental question of particular relevance to the given Arctic region, each year a comprehensive natural and social science GoNorth! Curriculum & Activity Guide (450+ pages) is developed reflecting the expedition's current Arctic locale and its indigenous culture. The associated online learning environment delivers comprehensive resources about the region of travel, collaborative opportunities, live field updates and field research findings synched real-time to the curriculum. Field research relevant to understanding patterns of climate change and polar science is conducted with independent researchers featured as "Cool GoNorth! Scientists." Collaborations span from scientists at NASA and the United States Department of Agriculture to student observers in pan-Arctic communities as part of the NSF-supported initiative "What Is Climate Change to You?." This scientific research and fieldwork in turn coincides with the curriculum. The result is a community of learners on the Internet gaining knowledge from Arctic

Factors that Influence Women's Technical Skill Development in Outdoor Adventure

Science.gov (United States)

Warren, Karen; Loeffler, TA

2006-01-01

This article provides a theoretical foundation for understanding women's technical skill development (TSD) in outdoor adventure. An examination of societal and biological factors influencing women's TSD focuses on gender role socialization, sense of competence, technical conditioning, sexism, spatial ability, and risk-taking. The article suggests…

Artificial Intelligence in a German Adventure Game: Spion in PROLOG.

Science.gov (United States)

Molla, Steven R.; And Others

1988-01-01

Spion, an adventure game for intermediate and advanced college German students, requires players to communicate with a fictitious agent in complete, correct German sentences. The spy game was written in PROLOG, runs on an IBM-PC, and is available at no cost for noncommercial purposes. (Author/CB)

Challenges in the delivery of adventure education: The case of ...

African Journals Online (AJOL)

This qualitative study explored the substantive issues and challenges faced by Physical Education teachers in delivering adventure education in the context of Botswana junior secondary schools. In the first stage of the study, 22 respondents completed a semi-structured questionnaire requesting information pertaining to the ...

The Censorship of the "Adventures of Huckleberry Finn": An Investigation.

Science.gov (United States)

Cloonan, Michele V.

1984-01-01

Explores reasons why "Adventures of Huckleberry Finn" has been continuously censored from its publication in 1885 to present. Historical precedents for censorship of library materials in the United States and specific censorship attempts are discussed. Controversial passages are examined in light of both praise and criticism.…

The international implementation of multisystemic therapy.

Science.gov (United States)

Schoenwald, Sonja K; Heiblum, Naamith; Saldana, Lisa; Henggeler, Scott W

2008-06-01

The purpose of this article is to consider, through the lenses of theory and research on technology transfer and the adoption and implementation of innovation, the international transport of evidence-based psychosocial treatments for youth, using Multisystemic Therapy (MST) as an example. MST is a well-validated family and community-based approach originally developed in the United States to treat serious juvenile offenders. This article describes challenges to MST transport internationally by virtue of the political, legal, economic, and cultural contexts in different nations. Modifications used to address these challenges and facilitate the international implementation of MST are described and pertain to pre-implementation processes, clinical staff, training materials and procedures, and clinical service delivery.

Conceptualizing Skill within a Participatory Ecological Approach to Outdoor Adventure

Science.gov (United States)

Mullins, Philip M.

2014-01-01

To answer calls for an ecological approach to outdoor adventure that can respond to the crisis of sustainability, this paper suggests greater theoretical and empirical attention to skill and skill development as shaping participant interactions with and experiences of environments, landscapes, places, and inhabitants. The paper reviews calls for…

Evaluation of Team Development in a Corporate Adventure Training Program.

Science.gov (United States)

Bronson, Jim; And Others

1992-01-01

An intact work unit of 17 corporate managers participated in a 3-day adventure training program to develop teamwork and group unity. The unit improved significantly on 8 of 10 items of the Team Development Inventory, administered before and 2 months after training, relative to an intact control group. (SV)

The Effect of Bad Human Activities on Marine Life as Portrayed in Sammy's Adventure: the Secret Passage

OpenAIRE

LATHIFAH, ISNA NUR

2015-01-01

Keywords: ecocriticism, bad humans activities, marine life, Sammy's Adventure: the Secret Passage movie. The balance of marine life is often damaged by irresponsible humans who do not care about their environment. This problem has inspired some works to criticize humans' reckless behavior toward environment, especially ocean. Sammy's Adventure: the Secret Passage is one of the examples that have been created to criticize the bad human activities in the ocean. This research applies ecocritici...

Thrill and adventure seeking in risky driving at work: The moderating role of safety climate.

Science.gov (United States)

Wishart, Darren; Somoray, Klaire; Evenhuis, Amanda

2017-12-01

Introduction Within many industrialized countries, the leading cause of worker fatalities and serious injuries can be attributed to road trauma. In non-occupational research, high levels of sensation seeking personality, and specifically thrill and adventure seeking, have been associated with risky driving behaviors. In work driving literature, high organizational safety climate has been associated with reduced risky driving in work drivers. However, the extent that factors such as safety climate and thrill seeking interact in regard to work driving safety remains unclear, and the current research examined this interaction. Methods A total of 1,011 work drivers from four organizations participated in the research. Surveys were distributed online and hardcopies were sent via mail. The survey included measures of thrill and adventure seeking, safety climate and work-related driving behaviors, as well as questions relating to participant demographics and information about their work driving. Results The results demonstrated that safety climate significantly moderated the effect of thrill and adventure seeking trait on driving errors, driving violations, and driving while fatigued. Conclusion These results suggest that the development of a strong safety climate has the potential to improve work driving safety outcomes by reducing the impact of particular personality traits such as thrill seeking within an organizational context. Practical application To improve work driving safety, organizations and management need to develop strategies to encourage and foster positive work driving safety climate, particularly within work settings that may attract thrill and adventure seeking employees. Copyright © 2017. Published by Elsevier Ltd.

Understanding Groups in Outdoor Adventure Education through Social Network Analysis

Science.gov (United States)

Jostad, Jeremy; Sibthorp, Jim; Paisley, Karen

2013-01-01

Relationships are a critical component to the experience of an outdoor adventure education (OAE) program, therefore, more fruitful ways of investigating groups is needed. Social network analysis (SNA) is an effective tool to study the relationship structure of small groups. This paper provides an explanation of SNA and shows how it was used by the…

R.L. Stevenson's 'Most Grim and Gloomy Tale': The Ebb-Tide as Deconstruction of Colonial Adventure Narrative

Directory of Open Access Journals (Sweden)

Christy Danelle Di Frances

2012-11-01

Full Text Available Although Edinburgh-born author Robert Louis Stevenson is best known as a writer of nineteenth-century popular adventures, his work to a great extent challenges prevailing adventure ideology of the Victorian era. This paper focuses on Stevenson's complexification of the villain trope in The Ebb-Tide, a South Seas novella published only a few months before his death in 1894. In the text, Stevenson blatantly disregards or dismantles typical colonial presentations of a simplistic villain personified through such topoi as the 'demonic male', the violent-but-beautiful female savage, or the vaguely formidable Other - all of which frequently populate adventure's exotic realm in nineteenth-century fiction. Rather than relying upon these culturally codified depictions, in The Ebb-Tide Stevenson presents villainy as embodied by a dangerous amalgamation of ordinary vice and extraordinary evil that traverses those national and ethnic boundaries that colonialism so often sought to demarcate and solidify. The portrayal of villainy within this text culminates in a nightmarish atmosphere which, in Stevenson's fiction, inevitably results from the unchecked workings of personal transgressions combined with a larger and more powerful indicator of evil. In so doing, the author succeeds in creating a dark narrative latent with culturally relevant commentary which, in turn, contributes to his broader re-navigation of an ethically-charged aesthetics of adventure for a modern audience.

Postoperative internal iliac artery embolisation as salvage therapy ...

African Journals Online (AJOL)

Postoperative internal iliac artery embolisation as salvage therapy for ... of blood products. Damage control surgery was performed, and bleeding was ultimately only ... abdomen was packed with adrenalin-soaked swabs. Coagulation.

Pembuatan Aplikasi Permainan Pengenalan Provinsi di Indonesia Melalui Game “Adventure Indonesia” Berbasis Android

Directory of Open Access Journals (Sweden)

Yusuf Ashari

2016-04-01

Full Text Available Indonesia adalah Negara yang luas dan kaya akan keanekaragaman aspek keruangan. Secara administratif menurut UU RI Nomor 20 Tahun 2012 Indonesia tentang pembentukan provinsi Kalimantan Utara yang menjadikan Indonesia terdiri dari 34 Provinsi. Hal ini berdampak terhadap aspek kehidupan terutama pada aspek pendidikan. Pada tingkat sekolah dasar siswa telah diajarkan untuk mengenal wilayah Indonesia. untuk mempermudah siswa sekolah dasar dalam memahami dan mengenal provinsi dibutuhkan suatu aplikasi edukasi yang dapat mengenalkan karakteristik dan nama ibukota dari provinsi di Indonesia oleh karena itu muncul sebuah ide untuk merancang dan membangun aplikasi permainan “Adventure Indonesia” ini diharapkan menjadi sarana permainan tentang pengenalan provinsi di Indonesia. Aplikasi permainan 'Adventure Indonesia' dibuat menggunakan perangkat lunak Unity versi 5. Pengembangan multimedia yang digunakan adalah Multimedia Development Life Cycle (MDLC yang memiliki enam tahap, yaitu tahap konsep (Concept, tahap perancangan (Design, tahap pengumpulan materi (Material Collecting, tahap pembuatan (Assembly, tahap pengujian (testing, dan tahap distribusi (Distribution. Pengujian black-box juga digunakan pada aplikasi ini. Hasil dari penelitian adalah berupa aplikasi permainan “Adventure Indonesia” yang dapat berjalan pada perangkat berbasis android. Aplikasi ini berisi pengenalan karakteristik dan ibukota dari provinsi di Indonesia. Berdasarkan pengujian dengan menggunakan metode black-box, seluruh fungsi yang ada dalam aplikasi permainan telah berhasil dan berjalan sesuai dengan fungsinya masing-masing.

The implementation of risk management in adventurous activities in Greece: The «Trekking Hellas» company

Directory of Open Access Journals (Sweden)

ANNA DIMITRIADI

2006-01-01

Full Text Available Adventurous activities can be both beneficial and perilous for health, because the circumstances differ and because of external and not always controllable factors, which may influence the outcomes. Therefore, any company, which organises adventurous activities, needs to present effective risk management and valuable safety measures in order to respond to its participants’ safety and satisfaction. This study, which was performed in the Greek company «Trekking Hellas», aimed at asserting the importance of risk management for adventure tourism. The data that were collected through personal, semi – structured interviews with the company’s managers and participants have shown that the particular company has made notable attempts to establish an organised and well-controlled risk management. This has been accomplished through implementing a methodical risk assessment and operating all necessary safety measures. The research, also, discussed the influence that the above might have had on the clients’ motivation for participation. Finally, the data have pointed out the significance that risk management has for the success of every activity and in extent, for the success and promotion of the company.

CREATING NEW MARKETING STRATEGY FOR CASE COMPANY ADVENTURE NET

OpenAIRE

Koleva, Hristina

2017-01-01

The purpose of this thesis was to create new, more successful marketing strategy for case company Adventure Net through analyzing the current marketing strategy and market environment of the company. The tools included in the theoretical part were used to analyze the market environment and marketing strategy. The analyzing tools included were PESTEL (Political, Economic, Social, Technological, Ecologic, Legal) analysis, SWOT (Strengths, Weaknesses, Threats, Opportunities) analysis and com...

Split, Croatia - Educational, Adventurous and Sustainable Tourism Destination

OpenAIRE

Chabik, Szymon; Imran, Md. Azim

2015-01-01

The purpose of this Bachelor’s thesis is to create an audio-visual documentation about an educational trip to Split, Croatia. The trip took place in April, 2014. The educational tour was organized by Laurea University of Applied Sciences. The destination, Split, were chosen by participants’ vote. The tour was arranged and planned by a group of students and the theme of the tour was Educational Tourism. The entire trip was taken into consideration from sustainable, Adventure and educational po...

Building International Sustainable Partnerships in Occupational Therapy: A Case Study.

Science.gov (United States)

Tupe, Debra Ann; Kern, Stephen B; Salvant, Sabrina; Talero, Pamela

2015-09-01

Occupational therapy practitioners frequently identify opportunities for international practice. The World Health Organization and the World Federation of Occupational Therapists have encouraged occupational therapists to address transnational issues, social inclusion, and equal access to opportunities grounded in meaningful occupation (WFOT, 2012). This case study describes a partnership between two U.S. schools of occupational therapy and a Cuban community based pediatric clinic. It examines the dynamics that have sustained the partnership despite political, economic, and logistical barriers. The literature is scrutinized to show how this case study fits into other accounts of collaborative international partnerships. Particularly, it investigates structural and institutional conditions that shape international sustainable partnerships. In doing so, we answer the following questions: (1) Under which circumstances do international partnerships emerge and flourish? (2) What structural and institutional conditions shape international sustainable partnerships? And (3) How do partners perceive and experience the bilateral international partnership? It also discusses and illustrates the foundations and development of international partnerships that succeed. Through the use of a case study we illustrate the development of this partnership. Finally, we consider the next steps of this particular sustainable and collaborative international partnership. © 2015 John Wiley & Sons, Ltd.

An international intercomparison of absorbed dose measurements for radiation therapy

International Nuclear Information System (INIS)

Taiman Kadni; Noriah Mod Ali

2002-01-01

Dose intercomparison on an international basis has become an important component of quality assurance measurement i.e. to check the performance of absorbed dose measurements in radiation therapy. The absorbed dose to water measurements for radiation therapy at the SSDL, MINT have been regularly compared through international intercomparison programmes organised by the IAEA Dosimetry Laboratory, Seibersdorf, Austria such as IAEA/WHO TLD postal dose quality audits and the Intercomparison of therapy level ionisation chamber calibration factors in terms of air kerma and absorbed dose to water calibration factors. The results of these intercomparison in terms of percentage deviations for Cobalt 60 gamma radiation and megavoltage x-ray from medical linear accelerators participated by the SSDL-MINT during the year 1985-2001 are within the acceptance limit. (Author)

Adventures in graph theory

CERN Document Server

Joyner, W David

2017-01-01

This textbook acts as a pathway to higher mathematics by seeking and illuminating the connections between graph theory and diverse fields of mathematics, such as calculus on manifolds, group theory, algebraic curves, Fourier analysis, cryptography and other areas of combinatorics. An overview of graph theory definitions and polynomial invariants for graphs prepares the reader for the subsequent dive into the applications of graph theory. To pique the reader’s interest in areas of possible exploration, recent results in mathematics appear throughout the book, accompanied with examples of related graphs, how they arise, and what their valuable uses are. The consequences of graph theory covered by the authors are complicated and far-reaching, so topics are always exhibited in a user-friendly manner with copious graphs, exercises, and Sage code for the computation of equations. Samples of the book’s source code can be found at github.com/springer-math/adventures-in-graph-theory. The text is geared towards ad...

Adlerian Adventure-Based Counseling to Enhance Self-Esteem in School Children

Science.gov (United States)

Wagner, Holly H.; Elliott, Anna

2014-01-01

This article provides a rationale for using adventure-based counseling (ABC) principles to promote children's self-esteem through group work within the school setting. The effectiveness of combining Adlerian theory with ABC to promote self-esteem is established. The process that would allow a school counselor to plan, organize, facilitate,…

Proceedings of the international heavy particle therapy workshop (PTCOG/EORTC/ECNEU)

International Nuclear Information System (INIS)

Blattmann, H.

1990-07-01

The International Heavy Particle Therapy Workshop at PSI was an experiment in several ways. For the PTCOG it was the first meeting outside the American continent. It was also the first meeting of PRCOG in conjunction with the EORTC Heavy Particle Therapy Group, which up to now has been dominated by discussion on neutron therapy. A common goal for radiotherapy as well as neutron therapy are all aiming at this goal by improved dose distribution and/or higher biological effectiveness. The meeting at Villigen was an attempt to stimulate discussion between the different groups and to strengthen international collaboration. The large number of proffered oral papers and posters was certainly a sign that the meeting served a need and that particle radiotherapy enjoys growing interest worldwide. 89 tabs., 164 figs., 441 refs

First Steps to the Last Frontier: Programming Suggestions for Alaskan Adventures.

Science.gov (United States)

Miner, Todd

This article provides an overview of trip programming in Alaska for those seeking a low-cost wilderness adventure. Alaska is a land of glaciers, mountains, lakes, rivers, forests, and wildlife. Safety is a major concern when traveling in Alaska. A local guide or outdoor educator can assist with safety and logistical planning. Travelers should plan…

Dose distribution following selective internal radiation therapy

International Nuclear Information System (INIS)

Fox, R.A.; Klemp, P.F.; Egan, G.; Mina, L.L.; Burton, M.A.; Gray, B.N.

1991-01-01

Selective Internal Radiation Therapy is the intrahepatic arterial injection of microspheres labelled with 90Y. The microspheres lodge in the precapillary circulation of tumor resulting in internal radiation therapy. The activity of the 90Y injected is managed by successive administrations of labelled microspheres and after each injection probing the liver with a calibrated beta probe to assess the dose to the superficial layers of normal tissue. Predicted doses of 75 Gy have been delivered without subsequent evidence of radiation damage to normal cells. This contrasts with the complications resulting from doses in excess of 30 Gy delivered from external beam radiotherapy. Detailed analysis of microsphere distribution in a cubic centimeter of normal liver and the calculation of dose to a 3-dimensional fine grid has shown that the radiation distribution created by the finite size and distribution of the microspheres results in an highly heterogeneous dose pattern. It has been shown that a third of normal liver will receive less than 33.7% of the dose predicted by assuming an homogeneous distribution of 90Y

Conceptual Design of Electrical Propulsion System for Nuclear Operated Vessel Adventurer

International Nuclear Information System (INIS)

Halimi, B.; Suh, K. Y.

2009-01-01

A design concept of the electric propulsion system for the Nuclear Operated Vessel Adventure (NOVA) is presented. NOVA employs Battery Omnibus Reactor Integral System (BORIS), a liquid metal cooled small fast integral reactor, and Modular Optimized Brayton Integral System (MOBIS), a supercritical CO 2 (SCO 2 ) Brayton cycle as power converter to Naval Application Vessel Integral System (NAVIS)

The Role of Outdoor Adventure Education in Facilitating Groupwork in Higher Education

Science.gov (United States)

Cooley, Sam J.; Burns, Victoria E.; Cumming, Jennifer

2015-01-01

Groupwork is an increasingly popular method of learning in higher education and the ability to work effectively with others is important for academic success and employability. This systematic review investigated the use of outdoor adventure education (OAE) in facilitating the development of transferable groupwork skills in higher education. The…

The LHIN adventure: The journey continues.

Science.gov (United States)

Huras, Paul; Switzer, Gary; Eliasoph, Hy

2015-11-01

The Local Health Integration Network (LHIN) adventure began 10 years ago with the intent of transforming the Ontario health system by providing system-based leadership and building collaborative capacity among health service providers. The LHIN construct has continued its evolution during this time and is still in the midst of testing and reshaping the boundaries of its mandate and authority. Working closely and in tandem with the Ministry of Health and Long-Term Care, LHINs have grappled with governance, funding, integration, and engagement, changing the nature of relationships and the dynamics inherent across the health system. The next decade holds considerable promise for LHINs and the health system in Ontario as a whole. © 2015 The Canadian College of Health Leaders.

Using text adventure games to entice learners to practice arithmetic skills over Mxit

CSIR Research Space (South Africa)

Butgereit, L

2009-01-01

Full Text Available examines a project where text adventure games with a mathematical twist are deployed over Mxit which participants can play on their cell phones. In order to complete the puzzles laid out in the game, participants must do various arithmetic calculations....

Sensation seeking in outdoor pursuits: similarities and differences in discourses on radical sports and adventure tourism / Da exacerbação dos sentidos no encontro com a natureza: contrastando esportes radicais e turismo de aventura

Directory of Open Access Journals (Sweden)

Mary Jane P. Spink

2005-01-01

Full Text Available This article is a contribution to the understanding of risk-adventure as the set of practices that recuperate the positive dimension of risk. Based on a review of the literature and on the theoretical approach of Constructionist Discursive Psychology, it proposes a model for the analysis of the dimensions of risk adventure present in adventure tourism and radical sports: risk/danger, adrenaline, adventure, training, use of equipments and relationship to nature. The data, derived from the site of a tourism agency that specialized in adventure tourism and an interview with a paraglide practitioner, was analyzed using "trees of association of ideas" and "dialogical maps". All the elements of the model were present in both modalities of risk-adventure. However, adventure tourism was characterized by the delegation of responsibility to specialists, whilst the training/experience dimension made itself more present in radical sports, along with greater emphasis on individual responsibility in the control of risks.

The value of outdoor adventure activities as part of the enviro course ...

African Journals Online (AJOL)

The value of outdoor adventure activities as part of the enviro course at Golden Gate Highlands National Park. Garth Johnson. Abstract. No Abstract. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · Creative Commons License This work is licensed under a ...

Constructing the Runaway Youth Problem: Boy Adventurers to Girl Prostitutes, 1960-1978.

Science.gov (United States)

Staller, Karen M.

2003-01-01

Examines, using a qualitative case study of stories printed in "The New York Times," the social construction of "runaway youth" in print media during 1960-1978. Finds that running away was an unconstructed problem (or simmering social condition) in the early 1960s and featured harmless adventures. Contributes to the…

Internal radiation dosimetry using nuclear medicine imaging in radionuclide therapy

International Nuclear Information System (INIS)

Kim, Kyeong Min; Byun, Byun Hyun; Cheon, Gi Jeong; Lim, Sang Moo

2007-01-01

Radionuclide therapy has been an important field in nuclear medicine. In radionuclide therapy, relevant evaluation of internally absorbed dose is essential for the achievement of efficient and sufficient treatment of incurable disease, and can be accomplished by means of accurate measurement of radioactivity in body and its changes with time. Recently, the advances of nuclear medicine imaging and multi modality imaging processing techniques can provide chance of more accurate and easier measurement of the measures commented above, in cooperation of conventional imaging based approaches. In this review, basic concept for internal dosimetry using nuclear medicine imaging is summarized with several check points which should be considered in real practice

The "Nature" of Leadership Philosophy in Outdoor and Adventure Education: Partnership or Predation

Science.gov (United States)

Uhlik, Kim S.

2006-01-01

Nature continually impresses humans in its role as an omnipresent, if not ultimate, source of power. One hallmark of outdoor and adventure education (OAE) has been its presumption that humans' interaction with aspects of Nature's "power" promotes the antecedents of leadership: measurable, persistent psychological effects and behavioral…

Autistic phenomena in The Adventures of Pinocchio.

Science.gov (United States)

Smith, Adrian

2017-04-01

This paper seeks to demonstrate that the protagonist of Carlo Collodi's The Adventures of Pinocchio illustrates numerous autistic phenomena such as communication difficulties, sensory and perceptual distortions and mindblindness. While Pinocchio is viewed as a literary construct with contraindications of autism, it will be argued that his autistic traits are sufficient to suggest the possibility that Collodi had a partial intuition of the syndrome 60 years before it was identified by Leo Kanner. Approaching Collodi's text in this manner is taken as an opportunity to survey and reflect upon the psychoanalytic literature on autism and to position it in relation to contemporary theories from cognitive neuroscience. © 2017, The Society of Analytical Psychology.

Adventure Education and the Acculturation of First-Generation Chinese Canadians in Vancouver, Canada

Science.gov (United States)

Lo, Simon; Gidlow, Bob; Cushman, Grant

2014-01-01

This article reports on research that demonstrates how parents in first-generation Chinese families in Vancouver, Canada, most of them from Hong Kong, control their children's involvement in local adventure education (AE) programs and in so doing minimize the likelihood of intergenerational culture conflict involving those children. The research…

Cranking Out Adventure: A Bike Leader's Guide to Trial and Error Touring.

Science.gov (United States)

Rohnke, Karl

The product of a 3,355 mile bicycle trip involving a co-ed group of teenagers and a leader (N=12), this guide to bike riding trips presents practical and philosophical insights gained by the Project Adventure leader who conducted the trip. Detailed lists of pre- and on-trip requirements are presented. Specifically, there are sections devoted to…

Judgment and Decision Making in Outdoor Adventure Leadership: A Dual-Process Model

Science.gov (United States)

Culp, Clinton A.

2016-01-01

From an examination of the current textbooks and literature concerning judgment and decision-making models used in outdoor adventure leadership, it is easy to see that they are still deeply rooted in the classical decision-making theory. In this article, I will (a) outline the importance of good judgment and decision making in an outdoor adventure…

A Journey of Freedom-seeking-A Character Analysis of The Adventure of Huckleberry Finn

Institute of Scientific and Technical Information of China (English)

谭险峰

2013-01-01

The thesis analyzes and comments on the two main characters in The Adventure of Huckleberry Finn so as to reveal the truth that to win both physical and psychological freedom in the society, we must learn to stand on ourselves. It begins with a brief introduction to the author, the novel and the paper thesis. Then, the author discloses the freedom-fighting process of the two main characters and the functions of Mississippi River and the raft in The Adventure of Huckleberry Finn: On the hegira, Huck realizes the cruelty, greed, murder, trickery, hypocrisy, racism, and a general lack of morality of the society;Jim, with his in-telligence and compassion, wins his freedom;the Mississippi River and the raft are symbols of freedom. Finally, the author reveals that to win both physical and psychological freedom, one must rely on his or her own efforts.

Peran Layanan Jasa Search Engine Optimization untuk Meningkatkan Daya Saing pada Bisnis Startup (Studi pada Kaldera Trail and Jeep Adventure Malang)

OpenAIRE

Wira Bharata

2016-01-01

This study aimed to investigate the role of SEO as a strategic competitive advantage. This study uses a qualitative approach with case studies are used as a research design. Researchers in the interviews to the owner Caldera Trail & Jeep Adventure. The results of this study indicate that the role of SEO to optimize the website proved successful in the company’s competitive advantage strategy Caldera Trail & Jeep Adventure. The results showed online marketing is done through Facebook, ...

Advances in neutron capture therapy 2006. Proceedings of 12th international congress on neutron capture therapy

International Nuclear Information System (INIS)

Nakagawa, Yoshinobu; Kobayashi, Tooru; Fukuda, Hiroshi

2006-01-01

The Twelfth International Congress on Neutron Capture Therapy (ICNCT-12) is being held from October 9th to 13th, 2006 at the Kagawa International Congress Hall in Takamatsu, Kagawa, Japan. The main theme of the congress is From the past to the Future'. Five symposiums were organized to accommodate all the contributions from the international scientific committees of the International Society for Neutron Capture Therapy (ISNCT), and two symposiums were added to balance the number of fields of specialties. The seven symposiums for ICNCT-12 are as follows: 1) Clinical Results of BNCT for Brain Tumors, 2) Dosimetry, 3) Treatment Planning system, 4) Drug Delivery System, 5) Biomedical and General Matters, 6) BNCT Systems using Accelerators, 7) New Applications and Protocols for BNCT. There are a total of 195 presentations in this congress: 3 special lectures, 34 symposium presentations, 10 presentations in two special sessions from the recipients of the Ralph G. Fairchild Award, 70 presentations in the oral parallel sessions and 78 presentations in the poster sessions. A compilation of 169 papers are published in this proceedings. The 165 of the presented papers are indexed individually. (J.P.N.)

New Perspectives for Teaching Physical Education: Preservice Teachers' Reflections on Outdoor and Adventure Education

Science.gov (United States)

Timken, Gay L.; McNamee, Jeff

2012-01-01

The purpose of this study was to gauge preservice physical education teachers' perspectives during one physical activity pedagogy course, teaching outdoor and adventure education. Teacher belief, occupational socialization and experiential learning theories overlaid this work. Over three years 57 students (37 males; 20 females) participated in the…

Outdoor Adventure Education in East Asia: Interpreting Data from Outward Bound Hong Kong

Science.gov (United States)

Sibthorp, Jim; Funnell, Aaron; Riley, Mike; Chan, Bacon; Meerts-Brandsma, Lisa

2018-01-01

Outdoor adventure education (OAE) is philosophically rooted in Western values, yet it has been implemented in non-Western cultures, such as East Asia. This paper examines how OAE functions in East Asia, through data from Hong Kong. Although some cultural differences are clear, there is no compelling evidence that OAE cannot provide benefits in…

From risky behaviour to sexy adventures: reconceptualising young people's online sexual activities.

Science.gov (United States)

Naezer, Marijke

2018-06-01

Western discourses about young people and sexuality centre around the concept of risk. Anxieties have been fuelled by the increasing popularity of social media and practices such as 'sexting' and watching 'sexually explicit' materials online. Research has shown however that such risk discourses mainly serve to moralise about, pathologise and police particular behaviours and children. In order to counter such paternalism, researchers advocated a reconceptualisation of youth not as passive victims, but as active agents who actively negotiate sexual experiences and discourses. In this paper, which is based on ethnographic fieldwork among young people in The Netherlands, I argue that we need a reconceptualisation not only of youth, but also of their sexual practices, especially their online sexual practices. Mobilising an interdisciplinary interaction between critical socio-cultural studies of risk, feminist theory and adventure studies, I propose to reconceptualise these practices as 'adventures' rather than 'risky behaviour'. This opens up possibilities for a more reasoned analysis that acknowledges: (1) the distinction between risks and outcomes of an activity; (2) the constructive potential of risk; and (3) the subjective, dynamic character of risk and pleasure.

Radiation therapy. 1990-2001. International Atomic Energy Agency publications

International Nuclear Information System (INIS)

2001-04-01

This catalog lists all sales publications of the International Atomic Energy Agency dealing with Radiation Therapy, and issued during the period 1 January 1990 - 30 April 2001. Most publications are issued in English, though some are also available in other languages. These are noted in the catalogue

Adventure sports and tourism at the beginning of the construction of Europe in the Pyrenees

Directory of Open Access Journals (Sweden)

André Suchet

2011-12-01

Full Text Available Organised in the spring of 1993 on the border between France and Spain, the Pyrenees Adventure Games (les Jeux Pyrénéens de l’Aventure or los Juegos Pirenaicos de la Aventura, brought together more than 1,000 athletes from 26 countries and were attended by 21,000 visitors. An alternative Olympics of adventure and outdoor sports patronised by the IOC, the events took place in the Aure Valley in France (Hautes-Pyrénées and in the Sobrarbe in Spain (Huesca province. This article analyses the governance of this international sports competition. More specifically, this case study will enable us to find out more about the conditions of organisation of a cross-border project in the early 1990s. What were the various political, social and cultural exchanges between the valleys in terms of sports and tourism in the Pyrenees? The results show that the French organisation and the Spanish organisation functioned side by side instead of working together on the field. This division in working enabled them to bypass the language problem. The cross-border dimension of these adventure Olympics in 1993 stemmed from pressure from the French regional planning agency, DATAR right from the beginning of the project, i.e. in October 1989, to be exact. This dimension made the 1993 Pyrenees Adventure Games a testimony to the new political Europe that was being built after 1989. This period was marked by the proactiveness of institutions, which far exceeded the motivations of the populations of the Union.Organisés au printemps 1993 sur la frontière entre la France et l’Espagne, les Jeux Pyrénéens de l’Aventure, ou los Juegos Pirenaicos de la Aventura, réunirent plus de 1 000 athlètes venus de 26 pays du monde sous les yeux de 21 000 visiteurs. Olympiade des sports d’aventure et de nature patronnée par le CIO, les épreuves se déroulèrent dans la vallée d’Aure en France (département des Hautes-Pyrénées et le Sobrarbe en Espagne (province de

Citizenship and Children's Identity in "The Wonderful Adventures of Nils" and "Scouting for Boys"

Science.gov (United States)

Sundmark, Bjorn

2009-01-01

"The Wonderful Adventures of Nils" (1906-1907) by Selma Lagerlof and "Scouting for Boys" (1908) by Robert Baden-Powell are characteristic of their time and their respective national and cultural contexts--the Swedish nation state of the early twentieth century and the British Empire. Taking its cue from recent theories on…

Dr. S. Donald (Don) Stookey (1915-2014): Pioneering Researcher and Adventurer

Science.gov (United States)

Beall, George H.

2016-07-01

Don Stookey, the father of glass-ceramics, was a pioneer in inducing and understanding internal nucleation phenomena in glass. His early work on dense opal glasses and photosensitive precipitation of gold and silver in glass led to an amazing series of inventions: Fotalite, a photosensitive opal, chemically machined Fotoform and Fotoceram, and TiO2-nucleated Pyroceram products including missile nosecones and oven-proof cookware. He received a basic patent on glass-ceramics, which was contested and affirmed in court. Don was able to demonstrate a clear photochromic glass that showed reversible darkening for thousands of cycles. This material became a fixture in the ophthalmic industry. He went on to invent a full-color polychromatic glass, capable of yielding a permanent patterned and monolithic stained glass. In his life outside science, Don chaired an interfaith group that founded a home for the elderly in Corning. He was also a wilderness enthusiast, surviving a plane crash in the Arctic and two boat capsizings. Even in his later years, he continued fishing off the coast of Florida and on Lake Ontario and went solo on a trip to the Patagonian Andes. Don Stookey was a special person by any measure: an unassuming optimist, eminent scientist and inventor, adventurer, and a beloved family man. Introduction

CSI Web Adventures: A Forensics Virtual Apprenticeship for Teaching Science and Inspiring STEM Careers

Science.gov (United States)

Miller, Leslie; Chang, Ching-I; Hoyt, Daniel

2010-01-01

CSI: The Experience, a traveling museum exhibit and a companion web adventure, was created through a grant from the National Science Foundation as a potential model for informal learning. The website was designed to enrich and complement the exhibit by modeling the forensic process. Substantive science, real-world lab techniques, and higher-level…

Caverns Measureless to Man: Subterranean Rivers and Adventurous Masculinities in the Victorian Lost World Novel

DEFF Research Database (Denmark)

McCausland, Elly

2018-01-01

This article examines a recurring trope in late Victorian ‘lost world’ adventure novels: the terrifying descent down a subterranean river into the bowels of the earth. More than simply an exciting episode, the subterranean river journey reflects narrative strategies and thematic concerns key to b...

PENGARUH CITRA MEREK (BRAND IMAGE DAN KEPUASAN WISATAWAN TERHADAP LOYALITAS WISATAWAN PADA BALI ADVENTURE RAFTING

Directory of Open Access Journals (Sweden)

Ardilla Nathaurisia

2017-01-01

Full Text Available ith loyalty and high power of buying. Research impact of brand image and guest satisfaction on customer loyalty is important to do in order to obtain an explanation of the relationship between brand image and customer satisfaction on customer loyalty. The purpose of this study is 1 to identify the circumstance brand image on customer loyalty. 2 to identify the circumstance customer satisfaction on customer loyalty. 3 to determine the circumstance brand image and customer satisfaction on customer loyalty. This research was conducted at Bali Adventure Rafting. Result shows that branding and customer satisfaction has a significant effect on customer loyalty in Bali Adventure Rafting with result 41,7%. This result is obtained from the value of determination D x 100% = 0,417 x 100% = 41,7%. This means that the brand image and customer satisfaction contributing positively to customer loyalty of rating of 41,7% and the remaining 58,3% is influenced by others factors such as costumers satisfaction, marketing strategy.

2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema

Directory of Open Access Journals (Sweden)

Bowen Tom

2010-07-01

Full Text Available Abstract Background We published the Canadian 2003 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema (HAE; C1 inhibitor [C1-INH] deficiency and updated this as Hereditary angioedema: a current state-of-the-art review: Canadian Hungarian 2007 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema. Objective To update the International Consensus Algorithm for the Diagnosis, Therapy and Management of Hereditary Angioedema (circa 2010. Methods The Canadian Hereditary Angioedema Network (CHAEN/Réseau Canadien d'angioédème héréditaire (RCAH http://www.haecanada.com and cosponsors University of Calgary and the Canadian Society of Allergy and Clinical Immunology (with an unrestricted educational grant from CSL Behring held our third Conference May 15th to 16th, 2010 in Toronto Canada to update our consensus approach. The Consensus document was reviewed at the meeting and then circulated for review. Results This manuscript is the 2010 International Consensus Algorithm for the Diagnosis, Therapy and Management of Hereditary Angioedema that resulted from that conference. Conclusions Consensus approach is only an interim guide to a complex disorder such as HAE and should be replaced as soon as possible with large phase III and IV clinical trials, meta analyses, and using data base registry validation of approaches including quality of life and cost benefit analyses, followed by large head-to-head clinical trials and then evidence-based guidelines and standards for HAE disease management.

A medical perspective on the adventures of Sherlock Holmes.

Science.gov (United States)

Reed, J

2001-12-01

The adventures of Sherlock Holmes, although primarily famous as stories of detection of crime, offer a considerable amount to interest the medical reader. There are many medical references in the stories, and the influence of Conan Doyle's medical background is clearly seen in the main characters. Aspects of the stories also reflect Conan Doyle's medical career, and also something of his attitude towards the profession. From Holmes's sayings and accounts of his methods, parallels can be drawn between Holmesian deduction and the diagnostic process. It is concluded, however, that deduction cannot be used as a direct paradigm since medical problems are rarely soluble through a process of logic alone.

KEMASAN PAKET WISATA JATILUWIH SIGHTSEEING AND ADVENTURE

Directory of Open Access Journals (Sweden)

Renita Sri Lestari

2017-01-01

Full Text Available This study discusses and examines potential identification and package tour in Tabanan regency. Qualitative approaches were applied in this research. The data were collected by using observation techniques, in-depths interviews, and documentation technique. Informant and key informant techniques were used to determine the informantion. This study used descriptive qualitative data analysis techniques with three steps which are data reduction, data display and conclusion drawing. In this study, showed potential identifications taken place in Alas Kedaton, Jatiluwih, Batukaru Temple, Subak Museum, and Tengkudak Village. The packaging of this package tour with itinerary such as visit the Subak Museum, Tengkudak village adventure, visit Jatiluwih, sightseeing in Batukaru temple, sightseeing in Alas Kedaton and shopping in Krisna oleh-oleh. This package tour was presented in tabulated style, Graphic style as well as the calculation of travel costs.

The ABC's of Delivering A Research-Driven Adventure Learning Program From the Field

Science.gov (United States)

Pregont, P.; Porsild, M.

2008-12-01

A is for anchoring the delivery of your research to your audience in a standard-aligned curriculum. B is for BGAN Satellite Communication System assisting in delivering real-time authentic media. C is for a collaborative online learning environment to engage learners" Z is for the peaceful sleep you will get once your program is up and running! As part of Team GoNorth! (http://www.PolarHusky.com) it is our job to deliver adventure learning. We set out to do this back when the computer was a 4-foot, 50-lb box powered by a hand-crank where one would have a window of ten minutes in a 24-hour period to catch the satellite (before Al Gore created the Internet!). Every year we review the quantum leaps in what is now possible from the field and in the classroom, and over the years we have wrestled technical issues, solutions and numerous re-structures in the process of our of curriculum development. With this presentation we will provide some basic ABC's on how you can remained focused on your research, yet deliver an adventure learning program for learners to investigate real-world issues within your scientific research. Our scales are most likely different. The volume of our curriculum is an annual production of 4-500 pages to be used from Kindergarden through 12th grade around the world. The framework of our online learning environment must be able to supports millions of users at a time. "In the field" means on a a 3-4 month dogsled expedition - so sending out our live updates involve thawing out the computers and setting up the satellite communication system to work in a ground blizzard! But regardless of the scope and location of your field research, you can probably build on some of our experiences in the planning of an upcoming adventure learning program to engage learners of all or any ages in your scientific explorations!

'Adventurous' judgments
A comparative exploration into human rights as a moral-political force in judicial law development

Directory of Open Access Journals (Sweden)

Bas de Gaay Fortman

2006-12-01

Full Text Available This article looks at the development of law by the judiciary in the sense of judgments taking the law beyond the point of what was hitherto regarded as ius positivum. Its main perspective, however, is not the creation of law by the courts as such, but rather the ways and means in which the human rights idea has encouraged judges to deliver decisions that imply an overturning of 'settled' law. In the comparative exploration of 'adventurous' judgments that we shall embark on, our focus will be on the political morality of human rights as a driving force in judicial activism. It is assumed, in other words, that where the judiciary is 'active', human rights may play a part as general principles of law as distinct from rules already incorporated in positive law. Notably then, human rights in this way affect positive law in a manner other than through processes of international, regional and national standard setting connected with the establishment of new supervisory institutions and mechanisms. For this reason, the article does not so much consider typical human rights cases; instead the focus is on major decisions by national courts that were not in the first place regarded as human rights cases at all. In this endeavour, the article aims to be no more than an initial comparative exploration, intended to illustrate a function of human rights that is not normally highlighted, namely its function as an inspirational force towards 'adventurous' judgments. Yet, the judicial potential illustrated here is of great significance, as it may lead to law development inspired by the two principal pillars underpinning the international quest for the realization of human rights: universality and human dignity. After reviewing a variety of characteristic cases from such diverse legal backgrounds as the United Kingdom, the Netherlands, the United States of America, India, South Africa and Nigeria, some conclusions are drawn as to the ways in which human rights

A biomedical adventurers' guide to navigating between careers in academia and industry.

Science.gov (United States)

Superti-Furga, Giulio

2009-12-01

An explosion of scientific and technological advances has broadened the field of biomedicine. Traditional boundaries between the public and private research sectors are now blurred by multidisciplinary projects and the necessity for new and more efficient models of the translational process. This allows the adventurous scientist to boldly and consciously sample selected skills during periods of secondment in different institutions and organizations, and to assemble a personal and unique blend of competences to help them manage their career.

Transformative Learning through International Immersion: Building Multicultural Competence in Family Therapy and Counseling

Science.gov (United States)

McDowell, Teresa; Goessling, Kristen; Melendez, Tatiana

2012-01-01

This study explores the experiences of graduate students who completed one of two international courses facilitated by family therapy faculty in a U.S. master's-level counseling psychology department. Participants reported that international courses were personally and professionally transformative. Spending time in a foreign country gave them…

More than Activities: Using a "Sense of Place" to Enrich Student Experience in Adventure Sport

Science.gov (United States)

Leather, Mark; Nicholls, Fiona

2016-01-01

There has been increasing interest in recent years in the significance of a sense of place in the literature of outdoor adventure education. In the UK relationships between outdoor education and the environment still appear largely focused on the science of the natural environment and the activity in question. In this paper, we present empirical…

Revisiting the Common Adventure Concept: An Annotated Review of the Literature, Misconceptions and Contemporary Perspectives.

Science.gov (United States)

Watters, Ron

In the 1970s a new form of outdoor trip programming appeared. Known as "common adventure," its best known trait is the absence of a designated leader. In 1970, Gary Grimm, the University of Oregon's first outdoor program coordinator, laid out the key principles: self-directed learning, formation of groups of people with similar interests…

Breaking Down the Stigma of Mental Illness through an Adventure Camp: A Collaborative Education Initiative.

Science.gov (United States)

Stuhlmiller, Cynthia M.

2003-01-01

Describes an outdoor adventure camp to help mental health consumers and nursing students explore the issues of mental health and illness through experiential and perceived risk challenges. Evaluation data reveals a breakdown in the stigma of mental illness as consumers and students came to know, trust, and count on each other in order to succeed…

Dr. S. Donald (Don Stookey: (1915-2014: Pioneering Researcher and Adventurer

Directory of Open Access Journals (Sweden)

George Halsey Beall

2016-08-01

Full Text Available Don Stookey was a special person by any measure: an unassuming optimist, eminent scientist and inventor, adventurer, and a beloved family man. Don Stookey, the father of glass-ceramics, was a pioneer in inducing and understanding internal nucleation phenomena in glass. His early work on dense opal glasses and photosensitive precipitation of gold and silver in glass led to an amazing series of inventions: Fotalite®, a photosensitive opal, chemically machined Fotoform® and Fotoceram®, and TiO2-nucleated Pyroceram™ products including missile nosecones and oven-proof cookware. He received a basic patent on glass-ceramics which was contested and affirmed in court.Don was able to demonstrate a clear photochromic glass that showed reversible darkening for thousands of cycles. This material became a fixture in the ophthalmic industry. He went on to invent a full-color polychromatic glass capable of yielding a permanent patterned and monolithic stained glass.In his life outside science, Don chaired an interfaith group that founded a home for the elderly in Corning. He was also a wilderness enthusiast, surviving a plane crash in the Arctic and two boat capsizings. Even In his later years, he continued fishing off the coast of Florida and on Lake Ontario, and went solo on a trip to the Patagonian Andes.

A grande aventura urbana The great urban adventure

Directory of Open Access Journals (Sweden)

Ângela Freire Prysthon

2008-11-01

Full Text Available Caiafa, Janice (2007. Aventura das cidades. ensaios e etnografias. Rio de Janeiro: Editora FGV. Em Aventura das cidades, Janice Caiafa reúne oito ensaios apresentados e publicados nos últimos anos. O tema central de sete deles é justamente a experiência urbana e a errância pelas metrópoles contemporâneas, o último traz à tona as questões metodológicas que permeiam as etnografias das cidades feitas pela autora. In Adventure of the Cities, Janice Caiafa compiles eight essays presented and published in recent years. The central theme of seven of these essays is, as indicated by the title, the urban experience and wandering through contemporary metropolises. The eighth essay broaches methodological issues that permeate the author's ethnographies of the city.

Risco e aventura no esporte na percepção do instrutor Risk and adventure in sport: instructor's perception

Directory of Open Access Journals (Sweden)

Jairo Antônio da Paixão

2011-08-01

Full Text Available O presente estudo analisa o risco na percepção de instrutores de esporte de aventura. A amostra foi constituída de 121 (cento e vinte e um instrutores de diferentes modalidades de esporte de aventura praticadas em Minas Gerais, com média de idade de 31 (trinta e um anos; considerou-se o desvio-padrão com significância This study analyzes the risk perceptions of adventure sports instructors. The sample consisted of 121 (one hundred and twenty-one instructors of different types of adventure sport practiced in Minas Gerais, with a mean age of 31 (thirty-one years. It was considered the standard deviation with significance >< 0,05%. The exploratory method was used in this study. Data collection took place from a questionnaire, validated in accordance with the Delphi technique, containing 15 items based on the theoretical literature. The results express that the risk perceived by the instructors is the most genuine risk-filled adventure of the sense of play. When considering procedures and recommendations that aim to predict, calculate and minimize the risk unexpected, it was found that the perception of risk by the instructors is due to an attitude which prevails in the domain of technique and quality equipment at the time these bodily practices close to nature.

Using Outdoor Adventure Education to Develop Students' Groupwork Skills: A Quantitative Exploration of Reaction and Learning

Science.gov (United States)

Cooley, Sam J.; Burns, Victoria E.; Cumming, Jennifer

2016-01-01

This study investigates the initial development of groupwork skills through outdoor adventure education (OAE) and the factors that predict the extent of this development, using the first two levels of Kirkpatrick's model of training evaluation. University students (N = 238) completed questionnaires measuring their initial reactions to OAE (Level 1…

Let's Begin Again: Sierra On-Line and the Origins of the Graphical Adventure Game

Science.gov (United States)

Nooney, Laine

2017-01-01

The author retells the origin story of Sierra On-Line and its historic first product, the graphical adventure game "Mystery House." She reviews the academic and journalistic writing that placed the story almost exclusively inside a narrative about early computer games, treating it as a saga of the competition between the graphic…

[Corticosteroid therapy and therapeutic education: experience of an internal medicine department

NARCIS (Netherlands)

Simon, A.; Ane, A.M.; Afroun, A.

2013-01-01

In 2003, we sought to determine what were the needs of patients prescribed with long-term glucocorticoid therapy in our internal medicine department. Following this inventory, we decided to homogenize the medical practices regarding glucocorticoid prescriptions in our institution. We also set up a

Dynamic Music and Immersion in the Action-Adventure

DEFF Research Database (Denmark)

Gasselseder, Hans-Peter

2014-01-01

in the context of dynamic and non-dynamic music. 60 subjects answered self-report questionnaires each time after playing a 3rd-person action-adventure in one of three conditions accounting for (1) dynamic music, (2) non-dynamic music/low arousal potential and (3) non-dynamic music/high arousal potential......Aiming to immerse players into a new realm of drama experience, a growing number of video games utilize interactive, ‘dynamic’ music that reacts adaptively to game events. Though little is known about the involved perceptual processes, the design rationale of enhanced immersive experiences is taken...... over by public discussion including scientific accounts, despite lacking empirical validation. The present paper intends to fill this gap by hypothesizing facilitatory effects of dynamic music on attention allocation in the matching of expected and incoming expressive characteristics of concurrent...

Satisfying Psychological Needs on the High Seas: Explaining Increases Self-Esteem Following an Adventure Education Programme

Science.gov (United States)

Scarf, Damian; Kafka, Sarah; Hayhurst, Jill; Jang, Kyungho; Boyes, Mike; Thomson, Ruth; Hunter, John A.

2018-01-01

A number of recent studies have revealed that taking part in a sail-training-based Adventure Education Programme elevates youths' self-esteem. Across two studies, we sought to examine the extent to which youths' sense of belonging contributed to this increase in self-esteem. Study 1 revealed that participants who completed the voyage showed an…

STUDENT’S SOFT SKILL ACQUISITION IN AN OUTDOOR ADVENTURE EDUCATION EVENT OVER TWO YEARS OF PARTICIPATION

Directory of Open Access Journals (Sweden)

S.J. Roos

2016-07-01

Full Text Available Outdoor Adventure Education can be used to develop and hone the transferable orso called soft skills such as group work and problem-solving skills in highereducation. These skills are also much needed to ensure employability. An outdooradventure activity was developed and implemented by lecturers in order to bridgethis gap between university and the industry in order to hone the transferableskills of students studying sport and recreation. Data were collected over twoyears. Two hundred students participated in the research study with a mean age of22±4 years. Data were collected qualitatively and analysed and subsequentlynumerically coded to ensure statistical analyses. Analyses indicated no statisticaldifferences between skills learned in the first and second year. Students were thendivided into first time and second time participants and statistical differences werefound. The second time participants reported mostly on leadership skills learnedand first time participants on teamwork. Implementingan outdoor AdventureEducation event was effective in developing skills in students much needed for success in higher education as well as becoming well-rounded individuals whompossess all the qualities for rewarding employment.

The entry-level occupational therapy clinical doctorate: advantages, challenges, and international issues to consider.

Science.gov (United States)

Brown, Ted; Crabtree, Jeffrey L; Mu, Keli; Wells, Joe

2015-04-01

Internationally, occupational therapy education has gone through several paradigm shifts during the last few decades, moving from certificate to diploma to bachelors to masters and now in some instances to clinical doctorate as the entry-level professional credential to practice. In the United States there is a recommendation under consideration by the American Occupational Therapy Association (AOTA) that by 2025, all occupational therapy university programs will move to the clinical doctorate level. It should be noted, however, that the AOTA Board can only make recommendations and it is the Accreditation Council for Occupational Therapy Education (ACOTE) who has regulatory authority to approve such a change. What are the potential implications for the profession, our clients, and funders of occupational therapy services? What are the primary drivers for the move towards the clinical doctorate being the educational entry point? Is the next step in the evolution of occupational therapy education globally a shift to the entry-level clinical doctorate? This article reviews current literature and discusses issues about the occupational therapy entry-level clinical doctorate. The published evidence available about the occupational therapy entry-level clinical doctorate is summarized and the perceived or frequently cited pros and cons of moving to the clinical doctorate as the singular entry point to occupational therapy practice are considered. The potential impacts of the introduction of the clinical doctorate as the entry-to-practice qualification across the United States on the occupational therapy community internationally will be briefly discussed. If the United States moves toward the entry-level clinical doctorate as the only educational starting point for the profession, will other jurisdictions follow suit? Further discourse and investigation of this issue both inside and outside of the United States is needed so that informed decisions can be made.

Green and Gold: Promoting Eco-Adventure and Cultural Tourism for Inclusive and Sustainable Growth

OpenAIRE

Picazo, Oscar F.

2015-01-01

This paper briefly reviews the literature on the emerging concept of eco-adventure and cultural tourism, dubbed "green and gold tourism," respectively. It provides the rationale for conducting such a study in the Philippines (why the concern for inclusivity and environmental sustainability in tourism). It then establishes the feasible scope of such study and lists illustrative activities of inclusive and sustainable green and gold tourism. It also identifies concerns and issues about green an...

To Capture Student Interest in Geosciences, Plan an Adventure

Science.gov (United States)

Sassier, Caroline; Galland, Olivier; Mair, Karen

2011-01-01

It is dawn, -17°C, and 4700 meters above sea level, and two young scientists are alone in a tiny tent in the middle of the immense desert of the Bolivian Altiplano. Their bicycles and sleeping bags are coated with a thin layer of ice. Muscles aching, as they did yesterday and probably will tomorrow, they shrug off their sleepiness as the sunrise heats up their tent. After a simple breakfast, the researchers peek out and feast their eyes on a stunning view of high volcanic peaks and salt lakes. They are on the Andean Geotrail, a 9-month bike adventure through the Andes mountains, from Ushuaia in Argentinean Tierra del Fuego to Nazca, Peru (see Figure 1). Their goal is to share this spectacular geological setting with primary-, secondary- and high-school students.

"A New Kind of Rule": The Subversive Narrator in "Alice's Adventures in Wonderland" and "The Pied Piper of Hamelin."

Science.gov (United States)

Blackburn, William

1986-01-01

Compares "Alice's Adventures in Wonderland" to "The Pied Piper of Hamelin," noting that both: (1) were begun for the amusement of specific children; (2) use a subterranean journey as a device; (3) are critical of social authority; and (4) have problematic endings. (SRT)

Environmental equipment for usages of FEM software. ADVENTURE system user's guide

International Nuclear Information System (INIS)

Yamasaki, Ichirou; Yoshimura, Shinobu

2003-05-01

The community softwares, databases, and other various tools have been installed in the ITBL environment by the Office of ITBL Promotion as a common utility property for each research field. Among those softwares, Finite Element Method (FEM) code, Adventure (which was originally developed by Prof. Yoshimura, the University of Tokyo), is provided as one of structure analysis programs for ITBL users. The code is well known to possess a high performance ability for parallel processing, especially for massively parallel environments. In this report, a chain of processes for usages of the system as well as the installation method to PC cluster are described. (author)

Implementasi Sistem Informasi Crm (Customer Relationship Management) (Studi Pada Ud. Iwek-p Adventure Kota Malang)

OpenAIRE

Randy, Muhammad Iqbal Dimasz

2014-01-01

The purpose of this minor thesis is to describe the customer relationship management of information system, to analize the problem of customer relationship management information system, and to give an alternative solution or a new customer relationship management information system recommendation to UD. Iwek-P Adventure. Through Customer Relationship Management, companies can improve interaction with customers, not only interact directly but also at the time online, and Customer Relationship...

Development of a real-time internal and external marker tracking system for particle therapy: a phantom study using patient tumor trajectory data.

Science.gov (United States)

Cho, Junsang; Cheon, Wonjoong; Ahn, Sanghee; Jung, Hyunuk; Sheen, Heesoon; Park, Hee Chul; Han, Youngyih

2017-09-01

Target motion-induced uncertainty in particle therapy is more complicated than that in X-ray therapy, requiring more accurate motion management. Therefore, a hybrid motion-tracking system that can track internal tumor motion and as well as an external surrogate of tumor motion was developed. Recently, many correlation tests between internal and external markers in X-ray therapy have been developed; however, the accuracy of such internal/external marker tracking systems, especially in particle therapy, has not yet been sufficiently tested. In this article, the process of installing an in-house hybrid internal/external motion-tracking system is described and the accuracy level of tracking system was acquired. Our results demonstrated that the developed in-house external/internal combined tracking system has submillimeter accuracy, and can be clinically used as a particle therapy system as well as a simulation system for moving tumor treatment. © The Author 2017. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology.

Reactions of Internal and External Test-Anxious Students to Counseling and Behavior Therapies

Science.gov (United States)

Friedman, Meredith L.; Dies, Robert R.

1974-01-01

Results from this study showed that external subjects provided with counseling and systematic desensitization felt that they retained too much control of therapy, while internals generally indicated an optional amount of control in counseling. (Author)

PENINGKATAN HASIL BELAJAR PERMAINAN BOLA KECIL SISWA KELAS VB TUNARUNGU DENGAN MENGGUNAKAN PERMAINAN BOLA ADVENTURE DALAM PEMBELAJARAN PENJAS DI SDLB NEGERI PURBALINGGA TAHUN AJARAN 2013 / 2014

Directory of Open Access Journals (Sweden)

Gallank Sasmita

2015-04-01

Full Text Available The purpose of this study was to determine the improvement of learning outcomes play small ball VB class deaf students using a ball game adventure in learning SDLB Purbalingga penjas in the academic year 2013/2014 . This study is an action research ( action research because of research done to solve the problem of learning in the classroom . Observations on cycle 1 , ie psychomotor aspects gained 65.47 % , 80.95 % gain cognitive and affective aspects of acquiring 100 % . In the first cycle the average value reached 78.92 class that meets both criteria . While the results of observations of cycle 2 , the psychomotor aspects of gaining 74.99 % , 90.47 % gain cognitive and affective aspects of acquiring 100 % . . In the second cycle the average value reached 84.4 classes that meet the criteria very well. Based on the above results , concluded that Ball Adventure games can improve learning outcomes of small ball . Therefore Penjasorkes teachers are advised to use the game as an alternative learning Adventure Ball Small Ball in SDLB.

Internal and External Triggering Mechanism of "Smart" Nanoparticle-Based DDSs in Targeted Tumor Therapy.

Science.gov (United States)

Qiana, Xian-Ling; Li, Jun; Wei, Ran; Lin, Hui; Xiong, Li-Xia

2018-05-09

Anticancer chemotherapeutics have a lot of problems via conventional drug delivery systems (DDSs), including non-specificity, burst release, severe side-effects, and damage to normal cells. Owing to its potential to circumventing these problems, nanotechnology has gained increasing attention in targeted tumor therapy. Chemotherapeutic drugs or genes encapsulated in nanoparticles could be used to target therapies to the tumor site in three ways: "passive", "active", and "smart" targeting. To summarize the mechanisms of various internal and external "smart" stimulating factors on the basis of findings from in vivo and in vitro studies. A thorough search of PubMed was conducted in order to identify the majority of trials, studies and novel articles related to the subject. Activated by internal triggering factors (pH, redox, enzyme, hypoxia, etc.) or external triggering factors (temperature, light of different wavelengths, ultrasound, magnetic fields, etc.), "smart" DDSs exhibit targeted delivery to the tumor site, and controlled release of chemotherapeutic drugs or genes. In this review article, we summarize and classify the internal and external triggering mechanism of "smart" nanoparticle-based DDSs in targeted tumor therapy, and the most recent research advances are illustrated for better understanding. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Differences in motivations over time by level of development: an examination of pre/post adventure recreation experiences

Science.gov (United States)

Sharon L. Todd; Lynn Anderson; Anderson Young; Dale Anderson

2003-01-01

The purpose of this study was to examine changes in motivations for outdoor adventure recreation pursuits over a short period of time (pre- to posttest) for participants with different levels of development. Subjects were 100 undergraduate recreation majors from separate similar summer session Outdoor Education Practicum courses, each of which included 7 days in a camp...

David Bowie’s Influence on JoJo’s Bizarre Adventure

Directory of Open Access Journals (Sweden)

Francesco-Alessio Ursini

2017-03-01

Full Text Available This article analyses the influence of David Bowie’s work in JoJo’s Bizarre Adventure, a manga known for its wealth of references to western popular culture. It is argued that David Bowie’s cultural reception can be attested via the presence of three narrative themes featuring in this manga series. The first theme is the exploration of diverse genres and an innovative, genre-defying attitude. The second theme is the use of avant-garde, flamboyant and gender-ambiguous aesthetics for its fictional characters. The third theme is a self-reflexive approach to the creation of fictional characters, intended as an awareness of the temporary, transient nature of their role as reluctant heroes in their own stories.

Improving Children's Mental Health with a Digital Social Skills Development Game: A Randomized Controlled Efficacy Trial of Adventures aboard the S.S. GRIN.

Science.gov (United States)

Sanchez, Rebecca; Brown, Emily; Kocher, Kelly; DeRosier, Melissa

2017-02-01

The purpose of this study was to investigate whether a computer-based game to improve social skills and mental health in children with social skills deficits would be efficacious. The program, Adventures aboard the S.S. GRIN, translates a proven in-person intervention into a nine-episode interactive online adventure game that provides opportunity for knowledge acquisition and skill practice. Participants (children aged 7-11 years with social skills challenges) were randomly assigned to immediate treatment group (n = 33) or waitlist control group (n = 36). Children in the immediate treatment condition completed the game at home over the course of 9 weeks. Before playing the game and again within 1 week of game completion, children completed surveys about social literacy, social anxiety, bullying, social self-efficacy, and social satisfaction. Children who played Adventures improved significantly more from pretest to posttest than children who did not play the game in social literacy, social anxiety, bullying victimization, and social satisfaction. Online interactive games can be effective in improving mental health for children who struggle with social skills. For children who can access them, serious games have the potential to increase the reach of effective programs by overcoming the logistical and implementation barriers (such as cost, travel, and accessibility) that limit traditionally delivered mental health interventions.

Stem Cell Gene Therapy for Fanconi Anemia: Report from the 1st International Fanconi Anemia Gene Therapy Working Group Meeting

Science.gov (United States)

Tolar, Jakub; Adair, Jennifer E; Antoniou, Michael; Bartholomae, Cynthia C; Becker, Pamela S; Blazar, Bruce R; Bueren, Juan; Carroll, Thomas; Cavazzana-Calvo, Marina; Clapp, D Wade; Dalgleish, Robert; Galy, Anne; Gaspar, H Bobby; Hanenberg, Helmut; Von Kalle, Christof; Kiem, Hans-Peter; Lindeman, Dirk; Naldini, Luigi; Navarro, Susana; Renella, Raffaele; Rio, Paula; Sevilla, Julián; Schmidt, Manfred; Verhoeyen, Els; Wagner, John E; Williams, David A; Thrasher, Adrian J

2011-01-01

Survival rates after allogeneic hematopoietic cell transplantation (HCT) for Fanconi anemia (FA) have increased dramatically since 2000. However, the use of autologous stem cell gene therapy, whereby the patient's own blood stem cells are modified to express the wild-type gene product, could potentially avoid the early and late complications of allogeneic HCT. Over the last decades, gene therapy has experienced a high degree of optimism interrupted by periods of diminished expectation. Optimism stems from recent examples of successful gene correction in several congenital immunodeficiencies, whereas diminished expectations come from the realization that gene therapy will not be free of side effects. The goal of the 1st International Fanconi Anemia Gene Therapy Working Group Meeting was to determine the optimal strategy for moving stem cell gene therapy into clinical trials for individuals with FA. To this end, key investigators examined vector design, transduction method, criteria for large-scale clinical-grade vector manufacture, hematopoietic cell preparation, and eligibility criteria for FA patients most likely to benefit. The report summarizes the roadmap for the development of gene therapy for FA. PMID:21540837

Uranium mines and French mining companies: a magnificent adventure

International Nuclear Information System (INIS)

Blanc, J.

2008-01-01

The French mining adventure still arouses enthusiasm. The search for uranium began in 1945 with the creation of the Cea (Atomic Energy Board) whose one mission was to supply the nascent French nuclear programme with the necessary materials. Prospecting works were then led throughout France, Madagascar, the Ivory Coast and the French equatorial Africa. More than 60 years later the only surviving actor of this quest for uranium has become the mining department of Areva Nuclear Cycle which is itself a sub-company of Areva. The author, who was an ancient high executive of Cogema draws a detailed history of the French uranium mining industry with with its ups and downs, by analysing the impact of the 2 oil crisis and of the decline of nuclear energy in the decade following the Chernobyl accident. (A.C.)

Sonia-Ania-Alisa, or, Alice’s Adventures in Russianland

Directory of Open Access Journals (Sweden)

Ilaria Sicari

2016-02-01

Full Text Available Lewis Carroll’s Alice’s Adventures in Wonderland (1865 is a text rich of cultural and literary references to Victorian England. This feature is one of the major obstacles to translating this work since the transfer of cultural markers from source to target text often produces partial or total loss of certain nuances of meaning. The purpose of this paper is to analyze the Russian translations of Alice through a comparative study of three translation specimens (Nabokov 1923; Olenič-Gnenenko 1940; Demurova 1967, 1978, which constitute just as many methods (domestication, foreignization, hybridization. Through the study of some difficult cases of translation – proper names with culture-specific connotations, puns and parodies – I will highlight the specificities of these different versions to understand whether and how the translator’s choices have affected the reception of Wonderland in Russia.

Adventures with cyanobacteria: a personal perspective

Directory of Open Access Journals (Sweden)

Govindjee e

2011-07-01

Full Text Available Cyanobacteria, or the blue-green algae as they used to be called until 1974, are the oldest oxygenic photosynthesizers. We summarize here adventures with them since the early 1960s. This includes studies on light absorption by cyanobacteria, excitation energy transfer at room temperature down to liquid helium temperature, fluorescence (kinetics as well as spectra and its relationship to photosynthesis, and afterglow (or thermoluminescence from them. Further, we summarize experiments on their two-light reaction - two-pigment system, as well as the unique role of bicarbonate (hydrogen carbonate on the electron acceptor side of their photosystem II, PSII. This review, in addition, includes a discussion on the regulation of changes in phycobilins (mostly in PSII and chlorophyll a (Chl a; mostly in photosystem I, PSI under oscillating light, on the relationship of the slow fluorescence increase (the so-called S to M rise, especially in the presence of diuron in minute time scale with the so-called state-changes, and on the possibility of limited oxygen evolution in mixotrophic PSI (minus mutants, up to 30 minutes, in the presence of glucose. We end this review with a brief discussion on the position of cyanobacteria in the evolution of photosynthetic systems.

Side effects of cancer therapies. International classification and documentation systems

International Nuclear Information System (INIS)

Seegenschmiedt, M.H.

1998-01-01

The publication presents and explains verified, international classification and documentation systems for side effects induced by cancer treatments, applicable in general and clinical practice and clinical research, and covers in a clearly arranged manner the whole range of treatments, including acute and chronic side effects of chemotherapy and radiotherapy, surgery, or combined therapies. The book fills a long-felt need in tumor documentation and is a major contribution to quality assurance in clinical oncology in German-speaking countries. As most parts of the book are bilingual, presenting German and English texts and terminology, it satisfies the principles of interdisciplinarity and internationality. The tabulated form chosen for presentation of classification systems and criteria facilitate the user's approach as well as application in daily work. (orig./CB) [de

Peran Layanan Jasa Search Engine Optimization untuk Meningkatkan Daya Saing pada Bisnis Startup (Studi pada Kaldera Trail and Jeep Adventure Malang

Directory of Open Access Journals (Sweden)

Wira Bharata

2016-12-01

Full Text Available This study aimed to investigate the role of SEO as a strategic competitive advantage. This study uses a qualitative approach with case studies are used as a research design. Researchers in the interviews to the owner Caldera Trail & Jeep Adventure. The results of this study indicate that the role of SEO to optimize the website proved successful in the company’s competitive advantage strategy Caldera Trail & Jeep Adventure. The results showed online marketing is done through Facebook, Twitter, Instagram and website have a positive impact on sales in their services. Applying marketing strategies using social media-based social networks and websites are very efficient because of much greater use conventional marketing strategies. This study also emphasizes the social media as online advertising that can be used as a marketing strategy in today’s digital era.

Da exacerbação dos sentidos no encontro com a natureza: contrastando esportes radicais e turismo de aventura Sensation seeking in outdoor pursuits: similarities and differences in discourses on radical sports and adventure tourism

Directory of Open Access Journals (Sweden)

Mary Jane P. Spink

2005-04-01

Full Text Available Este artigo visa a contribuir para a compreensão do risco-aventura, entendido como o conjunto de práticas que recuperam a dimensão positiva dos riscos. Com base na revisão da literatura e apoiado na vertente construcionista da Psicologia Discursiva, propõe um modelo para análise das dimensões de risco-aventura presentes no turismo de aventura e nos esportes radicais: risco/perigo, adrenalina, aventura, treinamento, uso de equipamentos e relação com a natureza. Como fonte de dados, utilizamos o site de uma operadora especializada em turismo de aventura e uma entrevista com um praticante de parapente. Os dados coletados foram analisados utilizando árvores de associação de idéias e mapas dialógicos. Todos os elementos do modelo analítico se fizeram presentes nas duas modalidades de risco-aventura. Porém, o turismo de aventura caracterizou-se pela delegação do controle do risco a especialistas, enquanto que nos esportes radicais a dimensão treinamento/experiência foi priorizada, enfatizando-se a responsabilidade individual no controle dos riscos.This article is a contribution to the understanding of risk-adventure as the set of practices that recuperate the positive dimension of risk. Based on a review of the literature and on the theoretical approach of Constructionist Discursive Psychology, it proposes a model for the analysis of the dimensions of risk adventure present in adventure tourism and radical sports: risk/danger, adrenaline, adventure, training, use of equipments and relationship to nature. The data, derived from the site of a tourism agency that specialized in adventure tourism and an interview with a paraglide practitioner, was analyzed using "trees of association of ideas" and "dialogical maps". All the elements of the model were present in both modalities of risk-adventure. However, adventure tourism was characterized by the delegation of responsibility to specialists, whilst the training/experience dimension made

Smart pH-responsive upconversion nanoparticles for enhanced tumor cellular internalization and near-infrared light-triggered photodynamic therapy.

Science.gov (United States)

Wang, Sheng; Zhang, Lei; Dong, Chunhong; Su, Lin; Wang, Hanjie; Chang, Jin

2015-01-01

A smart pH-responsive photodynamic therapy system based on upconversion nanoparticle loaded PEG coated polymeric lipid vesicles (RB-UPPLVs) was designed and prepared. These RB-UPPLVs which are promising agents for deep cancer photodynamic therapy applications can achieve enhanced tumor cellular internalization and near-infrared light-triggered photodynamic therapy.

2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema

DEFF Research Database (Denmark)

Bowen, Tom; Cicardi, Marco; Farkas, Henriette

2010-01-01

ABSTRACT: BACKGROUND: We published the Canadian 2003 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema (HAE; C1 inhibitor [C1-INH] deficiency) and updated this as Hereditary angioedema: a current state-of-the-art review: Canadian Hungarian 2007 ...

A Case Study Examining the Impact of Adventure Based Counseling on High School Adolescent Self-Esteem, Empathy, and Racism

Science.gov (United States)

Cale, Chris

2010-01-01

This study investigated the effectiveness of Adventure Based Counseling upon high school adolescents. The goals of this study were to (a) explore the effectiveness of ABC Counseling in increasing levels of self-esteem and empathy among adolescents; (b) study the efficacy of ABC counseling in reducing perceived racial discrimination, racist…

The Andean Geotrail (1): A scientific adventure

Science.gov (United States)

Sassier, C.; Galland, O.; Raufaste, C.; Mair, K.

2009-12-01

The role of Geosciences in our society is of primary importance. Its implications for humanity relate to major challenges such as climate change, managing energy resources, natural hazard mitigation, and water scarcity. Despite these issues being familiar to specialists, this is in general not the case for the public. In a world, where the impact of human activity is beginning to be seen on the environment, knowledge of the Earth and its history is paramount to make informed decisions that will influence our future. The necessity to educate the global population and raise awareness of Geosciences has led UNESCO to designate 2009 the International Year of the Planet Earth. In this context and with the label of the UNESCO, we organized and performed a popular science adventure that was followed in real time by both school children and many adults around the world. The Andean Geotrail consisted of a cycling expedition through a spectacular geological environment, the Andean Cordillera. During the nine month expedition, we cycled 8000 km and walked 400 km from Ushuaia in the Southern tip of Argentina to Nazca in Peru to encounter a rich variety of geological environments: active volcanoes, earthquakes, mineral and hydrocarbon deposits, and fantastic geological scenery. All this makes the Andes a great pedagogical natural laboratory. During the expedition, we visited spectacular geological localities that illustrate key Earth Science phenomena (such as mines and hydrocarbon deposits, erupting volcanoes and seismogenically active areas, and national parks) and discovered their implications for the local people. Along the way, we interviewed local geologists and scientists who helped us understand the geology of their areas. We gathered our own observations with those of the local specialists and published essays, articles and photographs on our website and blog (www.georouteandine.fr/English, http://georouteandine.blogspot.com). Seventeen schools in France and Norway

SOTUNKI: An Island Of Education and Adventure

Directory of Open Access Journals (Sweden)

Heidi HEIKKILÄ

2011-08-01

Full Text Available Last year some of the teachers of Sotunki Distance Learning Centre set out to find a new approach to teaching different subjects in Upper Secondary School. We wanted to do this by using social media and finally decided on using Second Life. I think social media like Second Life can offer a lot to our students who study via internet and rarely meet each other or their teachers. In Second Life students can meet their teachers, guidance counselors and fellow students face to face and in real time. This brings more interaction to the learning process and gives the students a chance to get to know each other. Also the interaction in Second Life is slightly different – it gives us teachers a different kind of chance to get to know our students better in a more informal way. There were many decisions to make when we first started building our school. We started by deciding on whether we wanted to have a traditional school building with traditional classrooms in it – and decided against it. Why repeat the real world in Second Life? What is the point of using a virtual world if not to benefit from the possibilities that the real world does not have? So we set out to do something new and extraordinary: instead of a school house we have a mountainous jungle waiting for explorers, and instead of classrooms we have lots of different innovations customized to fit the virtual world. It is important to us that students want to explore our island and learn while exploring it: learning can be a real adventure.I chose the course of history of literature as my project because Second Life has wonderful tools for creating historical settings. Building a pathway came naturally too: the history of literature is linear by nature; a pathway is its natural form. There are plenty of time periods in literature that have distinctive styles but I could not include them all. Finally I decided to build information points for eight different stylistic periods

Interventional therapy of traumatic pseudoaneurysms in internal carotid artery siphon

International Nuclear Information System (INIS)

Tang Jun; Shang Jianqiang; Chen Jie; Li Fengxin; Liu Yanjun

2007-01-01

Objective: To determine the methods and results of treating traumatic pseudoaneurysms in siphon segment of internal carotid artery (ICA)by interventional therapy. Methods: Twelve cases of traumatic pseudoaneurysms in siphon segment of internal carotid artery were treated. The collateral circulation of Willis circle was observed after DSA. Different methods of treatment were applied according to the collateral circulation of Willis circle. Ten cases were treated by occlusion of ICA completely, 1 case was embolized by guglielmi detachable coil (GDC) only. Results: Nine of 12 treated by occlusion of ICA were cured. In the 3 cases who had poor collateral of Willis circle, one was cured by GDC embolization alone; one died 48 hours later after ICA occlusion though his consciousness and the activity of extremities were normal during the temporary balloon test occlusion (BTO) of ICA. One died during the training to improve the collateral of the Willis circle. Conclusion: ICA embolization is feasible for treatment of traumatic pseudoaneurysms in siphon segment of internal carotid artery after evaluating the collateral circulation of Willis circle. (authors)

Exercise therapy for treatment of supraspinatus tears does not alter glenohumeral kinematics during internal/external rotation with the arm at the side.

Science.gov (United States)

Ferrer, Gerald A; Miller, R Matthew; Zlotnicki, Jason P; Tashman, Scott; Irrgang, James J; Musahl, Volker; Debski, Richard E

2018-01-01

Rotator cuff tears are a significant clinical problem, with exercise therapy being a common treatment option for patients. Failure rates of exercise therapy may be due to the failure to improve glenohumeral kinematics. Tears involving the supraspinatus may result in altered glenohumeral kinematics and joint instability for internal/external rotation with the arm at the side because not all muscles used to stabilize the glenohumeral joint are functioning normally. The objective of the study is to assess in vivo glenohumeral kinematic changes for internal/external rotation motions with the arm at the side of patients with a symptomatic full-thickness supraspinatus tear before and after a 12-week exercise therapy programme. Five patients underwent dynamic stereoradiography analysis before and after a 12-week exercise therapy protocol to measure changes in glenohumeral kinematics during transverse plane internal/external rotation with the arm at the side. Patient-reported outcomes and shoulder strength were also evaluated. No patient sought surgery immediately following exercise therapy. Significant improvements in isometric shoulder strength and patient-reported outcomes were observed (p internal/external rotation with the arm at the side. Despite satisfactory clinical outcomes following exercise therapy, glenohumeral kinematics did not change. The lack of changes may be due to the motion studied or the focus of current exercise therapy protocols being increasing shoulder strength and restoring range of motion. Current exercise therapy protocols should be adapted to also focus on restoring glenohumeral kinematics to improve joint stability since exercise therapy may have different effects depending on the motions of daily living. Prognostic study, Level II.

Extreme event medicine: considerations for the organisation of out-of-hospital care during obstacle, adventure and endurance competitions.

Science.gov (United States)

Laskowski-Jones, Linda; Caudell, Michael J; Hawkins, Seth C; Jones, Lawrence J; Dymond, Chelsea A; Cushing, Tracy; Gupta, Sanjey; Young, David S; Starling, Jennifer M; Bounds, Richard

2017-10-01

Obstacle, adventure and endurance competitions in challenging or remote settings are increasing in popularity. A literature search indicates a dearth of evidence-based research on the organisation of medical care for wilderness competitions. The organisation of medical care for each event is best tailored to specific race components, participant characteristics, geography, risk assessments, legal requirements, and the availability of both local and outside resources. Considering the health risks and logistical complexities inherent in these events, there is a compelling need for guiding principles that bridge the fields of wilderness medicine and sports medicine in providing a framework for the organisation of medical care delivery during wilderness and remote obstacle, adventure and endurance competitions. This narrative review, authored by experts in wilderness and operational medicine, provides such a framework. The primary goal is to assist organisers and medical providers in planning for sporting events in which participants are in situations or locations that exceed the capacity of local emergency medical services resources. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Going beyond: an adventure- and recreation-based group intervention promotes well-being and weight loss in schizophrenia.

Science.gov (United States)

Voruganti, Lakshmi N P; Whatham, Jeff; Bard, Eleanor; Parker, Gayle; Babbey, Candice; Ryan, Janet; Lee, Suganya; MacCrimmon, Duncan J

2006-08-01

To undertake a preliminary study to assess the feasibility of clinical implementation and evaluate the effectiveness of a novel adventure- and recreation-based group intervention in the rehabilitation of individuals with schizophrenia. In a 2-year, prospective, case-control study, 23 consecutively referred, clinically stabilized schizophrenia patients received the new intervention over an 8-month period; 31 patients on the wait list, considered the control group, received standard clinical care that included some recreational activities. Symptom severity, self-esteem, self-appraised cognitive abilities, and functioning were documented for both groups with standardized rating scales administered at baseline, on completion of treatment, and at 12 months posttreatment. Treatment adherence was 97%, and there were no dropouts. Patients in the study group showed marginal improvement in perceived cognitive abilities and on domain-specific functioning measures but experienced a significant improvement in their self-esteem and global functioning (P < 0.05), as well as a weight loss of over 12 lb. Improvement was sustained over 1 year with further occupational and social gains. In the context of overcoming barriers to providing early intervention for youth and preventing metabolic problems among older adults with schizophrenia, adventure- and recreation-based interventions could play a useful complementary role.

Investigating the experience of outdoor and adventurous project work in an educational setting using a self-determination framework

OpenAIRE

Sproule, J.; Martindale, R.; Wang, J.; Allison, P.; Nash, C.; Gray, S.

2013-01-01

The purpose of this study was to carry out a preliminary investigation to explore the use ofoutdoor and adventurous project work (PW) within an educational setting. Specifically, differencesbetween the PW and normal academic school experiences were examined using a selfdeterminationtheory framework integrated with a goal orientation and psychological skills perspective.Additionally, an exploratory investigation was carried out to examine the extent to which key motivation constructs predicted...

Environmental equipment for usages of FEM software. ADVENTURE system user's guide

Energy Technology Data Exchange (ETDEWEB)

Yamasaki, Ichirou [Japan Atomic Energy Research Inst., Center for Promotion of Computional Science and Engineering, Kizu, Kyoto (Japan); Yoshimura, Shinobu [Tokyo Univ., Tokyo (Japan)

2003-05-01

The community softwares, databases, and other various tools have been installed in the ITBL environment by the Office of ITBL Promotion as a common utility property for each research field. Among those softwares, Finite Element Method (FEM) code, Adventure (which was originally developed by Prof. Yoshimura, the University of Tokyo), is provided as one of structure analysis programs for ITBL users. The code is well known to possess a high performance ability for parallel processing, especially for massively parallel environments. In this report, a chain of processes for usages of the system as well as the installation method to PC cluster are described. (author)

Stamina, speed and adventure: Australian women and competitive cycling in the 1890s.

Science.gov (United States)

Kinsey, Fiona

2011-01-01

The scholarship surrounding women's cycling in Australia during the 1890s is slim. However, a focus on female competitive cycling, just one of many diverse cycling activities that women pursued in this era, reveals a rich seam of information. Accordingly, this paper surveys endurance riding, adventure touring and racing, introducing new historical and biographical detail and highlighting the significance of competitive cycling for women in the late nineteenth century. The discussion shows that women's competitive cycling constituted a significant component of Australian cycling history, and helped to re-define women's identity in an era when feminine roles were in flux and the traditional gender order was being contested.

Telling It Like It Is--And Like It Is Not: Fiction in the Service of Science in Jay Hosler's "The Sandwalk Adventures"

Science.gov (United States)

Porat, Michal

2015-01-01

Biologist and graphic novelist Jay Hosler has long been introducing young readers to biological subjects through entertaining narratives combining strongly fictional elements with nonfictional ones. Extensive application of fiction to nonfictional subject matter is uncommon, even in graphic novels, but Hosler's "The Sandwalk Adventures"…

Selective internal radiation therapy (SIRT) for liver metastases secondary to colorectal adenocarcinoma

International Nuclear Information System (INIS)

Welsh, James S.; Kennedy, Andrew S.; Thomadsen, Bruce

2006-01-01

Introduction: Selective internal radiation therapy (SIRT) is a relatively new commercially available microbrachytherapy technique for treatment of malignant hepatic lesions using 9 Y embedded in resin microspheres, which are infused directly into the hepatic arterial circulation. It is FDA approved for liver metastases secondary to colorectal carcinoma and is under investigation for treatment of other liver malignancies, such as hepatocellular carcinoma and neuroendocrine malignancies. Materials/Methods: A modest number of clinical trials, preclinical animal studies, and dosimetric studies have been reported. Here we review several of the more important results. Results: High doses of beta radiation can be selectively delivered to tumors, resulting in impressive local control and survival rates. Ex vivo analyses have shown that microspheres preferentially cluster around the periphery of tumor nodules with a high tumor:normal tissue ratio of up to 200:1. Toxicity is usually mild, featuring fatigue, anorexia, nausea, abdominal discomfort, and slight elevations of liver function tests. Conclusions: Selective internal radiation therapy represents an effective means of controlling liver metastases from colorectal adenocarcinoma. Clinical trials have demonstrated improved local control of disease and survival with relatively low toxicity. Investigations of SIRT for other hepatic malignancies and in combination with newer chemotherapy agents and targeted biologic therapies are under way or in planning. A well-integrated team involving interventional radiology, nuclear medicine, medical oncology, surgical oncology, medical physics, and radiation oncology is essential for a successful program. Careful selection of patients through the combined expertise of the team can maximize therapeutic efficacy and reduce the potential for adverse effects

Maps to the other side adventures of a bipolar cartographer

CERN Document Server

DuBrul, Sascha Altman

2013-01-01

Part mad manifesto, part revolutionary love letter, part freight train adventure story — Maps to the Other Side is a self-reflective shattered mirror, a twist on the classic punk rock travel narrative that searches for authenticity and connection in the lives of strangers and the solidarity and limitations of underground community. Beginning at the edge of the internet age, a time when radical zine culture prefigured social networking sites, these timely writings paint an illuminated trail through a complex labyrinth of undocumented migrants, anarchist community organizers, brilliant visionary artists, revolutionary seed savers, punk rock historians, social justice farmers, radical mental health activists, and iconoclastic bridge builders. This book is a document of one person's odyssey to transform his experiences navigating the psychiatric system by building community in the face of adversity; a set of maps for how rebels and dreamers can survive and thrive in a crazy world.

Relation of psychological distress to the international normalized ratio in patients with venous thromboembolism with and without oral anticoagulant therapy.

Science.gov (United States)

Von Känel, R; Vökt, F; Biasiutti, F Demarmels; Stauber, S; Wuillemin, W A; Lukas, P S

2012-08-01

Psychological distress might affect the international normalized ratio (INR), but effects might vary depending on oral anticoagulant (OAC) therapy. To investigate the association of psychological distress with INR and clotting factors of the extrinsic pathway in patients with and without OAC therapy. We studied 190 patients with a previous venous thromboembolism (VTE); 148 had discontinued OAC therapy and 42 had ongoing OAC therapy. To assess psychological distress, all patients completed validated questionnaires to measure symptoms of depression, anxiety, worrying, anger and hostility. INR, fibrinogen, factor (F)II:C, FV:C, FVII:C and FX:C were measured as part of outpatient thrombophilia work-up. In VTE patients without OAC therapy, the odds of a reduced INR (therapy, INR was unrelated to a negative affect; however, lower FVII:C related to anxiety and worrying as well as lower FX:C related to anger and hostility were observed in patients with OAC therapy compared with those without OAC therapy. Psychological distress was associated with a reduced INR in VTE patients without OAC therapy. The direction of the association between psychological distress and activity in some clotting factors of the extrinsic coagulation pathway might differ depending on whether VTE patients are under OAC therapy or not. © 2012 International Society on Thrombosis and Haemostasis.

Bromélia Filminhos and the international adventures of Lottie Dottie Chicken

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Maria Luiza Carvalho de Aguillar Pinho

2015-09-01

Full Text Available This case study examines the trajectory of a company in the audiovisual industry, founded in 2006, responsible for the first Brazilian animated series whose artistic and authorial design was produced entirely in Brazil, to reach the one billion views milestone on YouTube. Created in 2007, the series became a massive hit with children by using the internet as a launching platform and so breaking with the established paradigm of using only traditional media (television and cinema to introduce an animated character. In just 18 months, the company had its brand licensed to more than 600 products, achieving almost 50% of its revenues from licensing in Brazil. In 2012, Bromélia Filminhos began their internationalization process. Management expected that international activities would soon account for 10% of the company revenues. This case study aims to discuss the internationalization of a small animation studio and the business potential for the licensing of Brazilian characters and brands at the national and international levels.

International collaboration including patients is essential to develop new therapies for patients with myositis.

Science.gov (United States)

Lundberg, Ingrid E; Vencovsky, Jiri

2017-05-01

To discuss the needs for international collaborations between investigators in different disciplines working with myositis and with patients with myositis. Recent advances in detection of several myositis-specific autoantibodies that are associated with distinct clinical phenotypes, will enable studies in new well defined clinically homogenous subgroups of myositis This is likely to lead to development of new information on molecular pathogenesis that might be different in different myositis subgroups. Subgrouping patients according to autoantibody profile may also be important to assess outcome, to identify prognostic biomarkers and in clinical trials. As these are rare disorders international collaboration is essential to enrol large enough cohorts of the subgroups. To facilitate such collaboration we have developed a web-based international myositis register, www.euromyositis.eu, which includes validated outcome measures and patient reported outcome measures. This register is to support research but also to support decision-making in the clinic. We welcome investigators to join the Euromyositis register. Myositis is a heterogeneous disorder with varying treatment response and outcome. There is a high unmet need for new therapies which can only be achieved by increased knowledge on molecular disease mechanisms. Subgrouping patients according to autoantibody profile may be a new way forward to get a better understanding on disease mechanisms and to develop novel therapies.

Tumor-Triggered Geometrical Shape Switch of Chimeric Peptide for Enhanced in Vivo Tumor Internalization and Photodynamic Therapy.

Science.gov (United States)

Han, Kai; Zhang, Jin; Zhang, Weiyun; Wang, Shibo; Xu, Luming; Zhang, Chi; Zhang, Xianzheng; Han, Heyou

2017-03-28

Geometrical shape of nanoparticles plays an important role in cellular internalization. However, the applicability in tumor selective therapeutics is still scarcely reported. In this article, we designed a tumor extracellular acidity-responsive chimeric peptide with geometrical shape switch for enhanced tumor internalization and photodynamic therapy. This chimeric peptide could self-assemble into spherical nanoparticles at physiological condition. While at tumor extracellular acidic microenvironment, chimeric peptide underwent detachment of acidity-sensitive 2,3-dimethylmaleic anhydride groups. The subsequent recovery of ionic complementarity between chimeric peptides resulted in formation of rod-like nanoparticles. Both in vitro and in vivo studies demonstrated that this acidity-triggered geometrical shape switch endowed chimeric peptide with accelerated internalization in tumor cells, prolonged accumulation in tumor tissue, enhanced photodynamic therapy, and minimal side effects. Our results suggested that fusing tumor microenvironment with geometrical shape switch should be a promising strategy for targeted drug delivery.

Pre-Participation Medical Evaluation for Adventure and Wilderness Watersports.

Science.gov (United States)

Nathanson, Andrew T; Young, Justin Mark J; Young, Craig

2015-12-01

A request for a preparticipation medical evaluation for wilderness watersports may be made by guiding agencies, instructional camps, or by patients presenting for an annual visit. Although guidelines have been published regarding preparticipation physical evaluation for traditional competitive high school and collegiate sports, little has been written about medical evaluations for those wishing to engage in wilderness and adventure watersports. in this article, we offer guidance based on literature review and expert opinion. Watersports are among the most common recreational activities in the United states and are generally safe. Drowning, however, is a significant risk, particularly in small, self-propelled craft, and among children. Medical counseling before participation in watersports should include screening for medical conditions which may impair swimming ability, including a history of seizures, heart disease, and lung disease. Physicians should also promote preventive health measures such as use of lifejackets and sun protection, as well as alcohol avoidance. Swim testing tailored to specific activities should be strongly considered for children and those with questionable swimming ability. Copyright © 2015. Published by Elsevier Inc.

The adventure of nuclear energy: a scientifical and industrial history

International Nuclear Information System (INIS)

Reuss, P.

2007-01-01

The nuclear energy history is one of the most exciting scientifical and industrial adventure. In France, in a few decades, nuclear energy has become the main energy source for power generation. The aim of this book is to present the stakes of this challenge, to better outline the difficulties that have been encountered all along its development in order to better understand the complexness of such a development. After an overview of the successive advances of atomic and nuclear physics since more than a century, the book describes the genesis of nuclear energy, its industrial developments and its still wide open perspectives. The conclusions makes a status of the advantages and risks linked with this energy source. The book contains also the testimonies of two French nuclear actors: P. Benoist and S. David. The forewords by H. Langevin, daughter of F. and I. Joliot-Curie, stresses on the past and future role of nuclear energy in the live synergy between research and industry. (J.S.)

The Impact of Adventure Based Activity at Malaysian National Service Training Programme on Team Cohesion: A Demographic Analysis.

OpenAIRE

Jaffry Zakaria; Mazuki Mohd Yasim; Md Amin Md Taff

2012-01-01

The present study examines the effects of physical module elements (adventure based activity) included in the Malaysian National Service Programme and to investigate the socio-demographic variables impact on team cohesion building among the participants. In this study, the participants were selected from three different camps, namely, Tasoh camp, Guar Chenderai camp and Meranti camp, located in the state of Perlis, Malaysia. The participants were those from the second batch intake in the yea...

Promoting Youth Development Worldwide: The Duke of Edinburgh’s International Award

Directory of Open Access Journals (Sweden)

Eva van Baren

2015-03-01

Full Text Available The Duke of Edinburgh’s International Award is a youth achievement Award program that aims to engage young people in purposeful activities focused on gaining knowledge, broadening horizons and accumulating a diversity of experiences. The program promotes positive youth development through an experienced based learning approach and is known to play a vital role in providing opportunities for young people to develop essential life skills, complementing their formal education. Comprised of three levels (Bronze, Silver and Gold and four sections (Service, Skills, Physical Recreation and Adventurous Journey the Award is designed to provide a balanced programme of personal development. The Award operates worldwide in over 140 countries and territories, through the International Award Association. This article will discuss The Duke of Edinburgh’s International Award program and its non-formal educational framework. Participants reported that it has enabled them to grow in confidence and in their ability to contribute positively to their communities.

Promoting international mobility in The Degree of Speech and Language Therapy: a case of an educational good practice

Directory of Open Access Journals (Sweden)

Nieves Mendizábal de la Cruz

2015-05-01

Full Text Available The constant modification of teaching and learning methods require the design of innovative strategies and the identification of educational good practices. The Degree of Speech and Language Therapy at theUniversityofValladolidhas developed various actions to promote international mobility of students and staff members, within the framework of interuniversity innovative educational projects. The objectives are: to make students aware of the role of the international dimension to increase the quality of their training; to expose innovative educational strategies to promote the international mobility; to foster internationalization of studies as a driver of research in this field; to establish Spanish as the language of reference in speech and language therapy. Descriptive methodology of performed actions was used. Results included: questionnaire sent to speech and language therapists in order to know their language skills and to enhance their importance, participation in courses, workshops and meetings, as well as in international mobility programs and exchange of experiences, teaching of subjects in English, publication of multilingual educational materials, contacts with American and European institutions and participation in international networks, blogging. It is concluded that the whole educative community should help to provide university programs of an international identity, and mobility should be provided of a social sense promoting equal opportunities for all groups.

Final Report: 8th International Symposium on Neutron Capture Therapy (NCT) for Cancer, May 15, 1998 - May 15, 1999

International Nuclear Information System (INIS)

Hawthorne, M.F.

1999-01-01

The 8th International Symposium on Neutron Capture Therapy for Cancer (8th ISNCTC) was held in La Jolla, CA on Sept. 13-18, 1998. This biennial meeting of the International Society for Neutron Capture Therapy (ISNCT) was hosted by Society President M.F. Hawthorne (UCLA Dept. of Chemistry and Biochemistry). The Symposium brought together scientists (300 registrants from 21 countries) from diverse fields to report the latest developments in NCT. Topics of the 275 papers presented (30 plenary lectures, 81 oral presentations, and 164 posters) included the physics of neutron sources, chemistry of tumor-targeting agents, dosimetry, radiobiological studies, and clinical applications

Music Therapy Practice Status and Trends Worldwide: An International Survey Study.

Science.gov (United States)

Kern, Petra; Tague, Daniel B

2017-11-01

The field of music therapy is growing worldwide. While there is a wealth of country-specific information available, only a few have databased workforce censuses. Currently, little to no descriptive data exists about the global development of the profession. The purpose of this study was to obtain descriptive data about current demographics, practice status, and clinical trends to inform worldwide advocacy efforts, training needs, and the sustainable development of the field. Music therapists (N = 2,495) who were professional members of organizations affiliated with the World Federation of Music Therapy (WFMT) served as a sample for this international cross-sectional survey study. A 30-item online questionnaire was designed, pilot tested by key partners, and translated into seven languages. Researchers and key partners distributed the online survey through e-mail invitations and social media announcements. Professional music therapists worldwide are well-educated, mature professionals with adequate work experience, who are confident in providing high-quality services primarily in mental health, school, and geriatric settings. Due to ongoing challenges related to recognition and government regulation of the field as an evidence-based and well-funded healthcare profession, most individuals work part-time music therapy jobs and feel underpaid. Yet, many music therapists have a positive outlook on the field's future. Continued research and advocacy efforts, as well as collaborations with lobbyists, business consultants, and credentialing/licensure experts to develop progressive strategies, will be crucial for global development and sustainability of the field. © the American Music Therapy Association 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

Internal dosimetry for the radiological protection of the patient in the therapy with I-131

International Nuclear Information System (INIS)

Deluca, G.M.; Rojo, A.M.

2006-01-01

In the patients with differentiated thyroid cancer (CADIT) subjected to therapy with radiopharmaceuticals should be considered the possible risk of sharp depression of the bone marrow like consequence of the intolerance to the quantity of administered activity. The manifestation of the myelotoxicity can limit in a substantial way the future treatments and to deteriorate the predict of resolution of the illness. In this work it shows the physical-mathematical mark of a methodology for the estimated absorbed dose in bone marrow based in the MIRD scheme whose objective is to protect the one patient of the noxious and undesirable effects of the internal radiotherapy in organs that are not target of the same one. The formalism incorporates specific information of the patient and also peculiar characteristics of the internal therapy in patient with CADIT. The considerations are the following ones: (1) the main organ to protect is the bone marrow: (2) the accumulated activity, in bone marrow, it is obtained starting from measurements in blood: (3) the used isotope almost exclusively in this type of therapies is the 131 I; (4) it is used as radiopharmaceutical at the 131 INa that it is characterized to be a simple, inorganic and small molecule: (5) the statistical incidence of the CADIT is bigger in women than in men. It is explained for that it was selected the formalism that is presented, the principles on which it is sustained which are their reaches and their limitations. They are also presented future innovations that can be implemented to effects of improving the estimates. The work is framed inside the thematic of the medical applications of open radioactive sources and it constitutes a contribution to the invigoration of the internal therapy with radiopharmaceuticals. This is due to that the methodology of dose estimation presented supplements with a theoretical biophysics base the protocols of empiric prescription broadly used in this practice. For these reasons

Feasibility, safety and outcomes of playing Kinect Adventures!™ for people with Parkinson's disease: a pilot study.

Science.gov (United States)

Pompeu, J E; Arduini, L A; Botelho, A R; Fonseca, M B F; Pompeu, S M A A; Torriani-Pasin, C; Deutsch, J E

2014-06-01

To assess the feasibility, safety and outcomes of playing Microsoft Kinect Adventures™ for people with Parkinson's disease in order to guide the design of a randomised clinical trial. Single-group, blinded trial. Rehabilitation Center of São Camilo University, Brazil. Seven patients (six males, one female) with Parkinson's disease (Hoehn and Yahr Stages 2 and 3). Fourteen 60-minute sessions, three times per week, playing four games of Kinect Adventures! The feasibility and safety outcomes were patients' game performance and adverse events, respectively. The clinical outcomes were the 6-minute walk test, Balance Evaluation System Test, Dynamic Gait Index and Parkinson's Disease Questionnaire (PDQ-39). Patients' scores for the four games showed improvement. The mean [standard deviation (SD)] scores in the first and last sessions of the Space Pop game were 151 (36) and 198 (29), respectively [mean (SD) difference 47 (7), 95% confidence interval 15 to 79]. There were no adverse events. Improvements were also seen in the 6-minute walk test, Balance Evaluation System Test, Dynamic Gait Index and PDQ-39 following training. Kinect-based training was safe and feasible for people with Parkinson's disease (Hoehn and Yahr Stages 2 and 3). Patients improved their scores for all four games. No serious adverse events occurred during training with Kinect Adventures!, which promoted improvement in activities (balance and gait), body functions (cardiopulmonary aptitude) and participation (quality of life). Copyright © 2013 Chartered Society of Physiotherapy. Published by Elsevier Ltd. All rights reserved.

TRANSALPINA CAN EASILY BE CONSIDERED THE DIAMOND COUNTRY LANDSCAPES, ADVENTURE AND MYSTERY

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Constanta ENEA

2014-05-01

Full Text Available If Transfăgărăşan is pearl Romanian mountains, the road easily qill be considered the diamond country landscapes, adventure and mystery. Hell 's Kitchen has developed and evolved naturally. Have no certainty of success and money required to carry out the infrastructure first and then see if investors come, so we can not blame the local authorities find here. The difficulties encountered in implementing funding programs made for funds to obtain hard enough. In this paper, I will briefly mention some ideas that could make the two cities, the holder of administratively to Rancière, the burgeoning tourist development area of Gorj County. I sincerely hope uhat there is among us and other people with vision who want to stand up and take action to provide a decent future for our children.

[Development and Effects of a Cognitive-behavioral Therapy Based Program in Reducing Internalized Stigma in Patients with Schizophrenia].

Science.gov (United States)

Kim, Mi Young; Jun, Seong Sook

2016-06-01

This study was done to develop a internalized stigma reducing program based on cognitive-behavioral therapy and appropriate for patients with schizophrenia and to evaluate its effectiveness. The study design was a mixed method research. Qualitative study, 13 patients with schizophrenia who had experience in overcoming stigma were purposively chosen for interviews and data were analyzed using Giorgi method. Quantitative study, 64 patients with schizophrenia (experimental group=32, control group=32) were recruited. The cognitive-behavioral therapy-based program for reducing internalized stigma in patients with schizophrenia was provided for 8 weeks (12 sessions). Data were collected from June. 20, 2013 to Feb. 14, 2014. Quantitative data were analyzed using χ²-test, t-test, repeated measures ANOVA with the SPSS program. Qualitative results, from the experience of coping with stigma in patients with schizophrenia seventeen themes and five themes-clusters were drawn up. Quantitative results showed that internalized stigma, self-esteem, mental health recovery and quality of life were significantly better in the experimental group compared to the control group. Study findings indicate that this program for reducing internalized stigma in patients with schizophrenia is effective and can be recommended as a rehabilitation program intervention to help patients with schizophrenia to cope with internalized stigma.

Introducing the Use of a Semi-Structured Video Diary Room to Investigate Students' Learning Experiences during an Outdoor Adventure Education Groupwork Skills Course

Science.gov (United States)

Cooley, Sam J.; Holland, Mark J.; Cumming, Jennifer; Novakovic, Emily G.; Burns, Victoria E.

2014-01-01

Outdoor adventure education courses are used in higher education to develop transferable skills such as groupwork and problem-solving skills. There is a need for exploratory investigation into students' perceptions of this experience. This study aimed to develop an innovative qualitative data collection method, and to use it to explore…

The Paediatric Rheumatology International Trials Organisation provisional criteria for the evaluation of response to therapy in juvenile dermatomyositis

DEFF Research Database (Denmark)

Ruperto, Nicolino; Pistorio, Angela; Ravelli, Angelo

2010-01-01

To develop a provisional definition for the evaluation of response to therapy in juvenile dermatomyositis (DM) based on the Paediatric Rheumatology International Trials Organisation juvenile DM core set of variables....

RANCANG BANGUN APLIKASI PERMAINAN ADVENTURE OF FRUNIMAL UNTUK EDUKASI BAHASA INGGRIS BERBASIS ANDROID

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Muhamad Ridwan

2017-11-01

Full Text Available Penelitian ini bertujuan untuk membangun sebuah aplikasi permainan berjenis platformer game yang menghibur dengan tema buah dan hewan dalam bahasa inggris, dan untuk mengetahui kualitas aplikasi permainan tersebut menggunakan standar ISO 25010 dari aspek functional suitability, performance efficiency, compatibility, dan usability. Hasil dari penelitian dapat diketahui bahwa game edukasi bahasa Inggris “Adventure of Frunimal” berhasil dikembangkan dengan game engine Construct2 dengan metode pengembangan Multimedia Luther. Pengujian pada aspek functional suitability sudah memenuhi standar AQuA, pada aspek performance efficiency sudah memenuhi ambang batas aman yang ditetapkan oleh Little Eye dan tidak terjadi memory leak, pada aspek compatibility dapat berjalan pada OS Android dari versi Ice Cream Sandwich sampai Marshmallow, dan pada aspek usability secara keseluruhan didapatkan hasil baik dalam hal kegunaan, mudah digunakan dan dipelajari serta memuaskan.

EGF Functionalized Polymer-Coated Gold Nanoparticles Promote EGF Photostability and EGFR Internalization for Photothermal Therapy.

Directory of Open Access Journals (Sweden)

Catarina Oliveira Silva

Full Text Available The application of functionalized nanocarriers on photothermal therapy for cancer ablation has wide interest. The success of this application depends on the therapeutic efficiency and biocompatibility of the system, but also on the stability and biorecognition of the conjugated protein. This study aims at investigating the hypothesis that EGF functionalized polymer-coated gold nanoparticles promote EGF photostability and EGFR internalization, making these conjugated particles suitable for photothermal therapy. The conjugated gold nanoparticles (100-200 nm showed a plasmon absorption band located within the near-infrared range (650-900 nm, optimal for photothermal therapy applications. The effects of temperature, of polymer-coated gold nanoparticles and of UVB light (295nm on the fluorescence properties of EGF have been investigated with steady-state and time-resolved fluorescence spectroscopy. The fluorescence properties of EGF, including the formation of Trp and Tyr photoproducts, is modulated by temperature and by the intensity of the excitation light. The presence of polymeric-coated gold nanoparticles reduced or even avoided the formation of Trp and Tyr photoproducts when EGF is exposed to UVB light, protecting this way the structure and function of EGF. Cytotoxicity studies of conjugated nanoparticles carried out in normal-like human keratinocytes showed small, concentration dependent decreases in cell viability (0-25%. Moreover, conjugated nanoparticles could activate and induce the internalization of overexpressed Epidermal Growth Factor Receptor in human lung carcinoma cells. In conclusion, the gold nanoparticles conjugated with Epidermal Growth Factor and coated with biopolymers developed in this work, show a potential application for near infrared photothermal therapy, which may efficiently destroy solid tumours, reducing the damage of the healthy tissue.

EGF Functionalized Polymer-Coated Gold Nanoparticles Promote EGF Photostability and EGFR Internalization for Photothermal Therapy

Science.gov (United States)

Silva, Catarina Oliveira; Petersen, Steffen B.; Reis, Catarina Pinto; Rijo, Patrícia; Molpeceres, Jesús; Fernandes, Ana Sofia; Gonçalves, Odete; Gomes, Andreia C.; Correia, Isabel; Vorum, Henrik; Neves-Petersen, Maria Teresa

2016-01-01

The application of functionalized nanocarriers on photothermal therapy for cancer ablation has wide interest. The success of this application depends on the therapeutic efficiency and biocompatibility of the system, but also on the stability and biorecognition of the conjugated protein. This study aims at investigating the hypothesis that EGF functionalized polymer-coated gold nanoparticles promote EGF photostability and EGFR internalization, making these conjugated particles suitable for photothermal therapy. The conjugated gold nanoparticles (100–200 nm) showed a plasmon absorption band located within the near-infrared range (650–900 nm), optimal for photothermal therapy applications. The effects of temperature, of polymer-coated gold nanoparticles and of UVB light (295nm) on the fluorescence properties of EGF have been investigated with steady-state and time-resolved fluorescence spectroscopy. The fluorescence properties of EGF, including the formation of Trp and Tyr photoproducts, is modulated by temperature and by the intensity of the excitation light. The presence of polymeric-coated gold nanoparticles reduced or even avoided the formation of Trp and Tyr photoproducts when EGF is exposed to UVB light, protecting this way the structure and function of EGF. Cytotoxicity studies of conjugated nanoparticles carried out in normal-like human keratinocytes showed small, concentration dependent decreases in cell viability (0–25%). Moreover, conjugated nanoparticles could activate and induce the internalization of overexpressed Epidermal Growth Factor Receptor in human lung carcinoma cells. In conclusion, the gold nanoparticles conjugated with Epidermal Growth Factor and coated with biopolymers developed in this work, show a potential application for near infrared photothermal therapy, which may efficiently destroy solid tumours, reducing the damage of the healthy tissue. PMID:27788212

Modern Radiation Therapy for Hodgkin Lymphoma: Field and Dose Guidelines From the International Lymphoma Radiation Oncology Group (ILROG)

International Nuclear Information System (INIS)

Specht, Lena; Yahalom, Joachim; Illidge, Tim; Berthelsen, Anne Kiil; Constine, Louis S.; Eich, Hans Theodor; Girinsky, Theodore; Hoppe, Richard T.; Mauch, Peter; Mikhaeel, N. George; Ng, Andrea

2014-01-01

Radiation therapy (RT) is the most effective single modality for local control of Hodgkin lymphoma (HL) and an important component of therapy for many patients. These guidelines have been developed to address the use of RT in HL in the modern era of combined modality treatment. The role of reduced volumes and doses is addressed, integrating modern imaging with 3-dimensional (3D) planning and advanced techniques of treatment delivery. The previously applied extended field (EF) and original involved field (IF) techniques, which treated larger volumes based on nodal stations, have now been replaced by the use of limited volumes, based solely on detectable nodal (and extranodal extension) involvement at presentation, using contrast-enhanced computed tomography, positron emission tomography/computed tomography, magnetic resonance imaging, or a combination of these techniques. The International Commission on Radiation Units and Measurements concepts of gross tumor volume, clinical target volume, internal target volume, and planning target volume are used for defining the targeted volumes. Newer treatment techniques, including intensity modulated radiation therapy, breath-hold, image guided radiation therapy, and 4-dimensional imaging, should be implemented when their use is expected to decrease significantly the risk for normal tissue damage while still achieving the primary goal of local tumor control. The highly conformal involved node radiation therapy (INRT), recently introduced for patients for whom optimal imaging is available, is explained. A new concept, involved site radiation therapy (ISRT), is introduced as the standard conformal therapy for the scenario, commonly encountered, wherein optimal imaging is not available. There is increasing evidence that RT doses used in the past are higher than necessary for disease control in this era of combined modality therapy. The use of INRT and of lower doses in early-stage HL is supported by available data. Although the

It's Time for an Adventure

Science.gov (United States)

Eldam Pommer, R.

2017-12-01

In recent years, studies have repeatedly illustrated the significance of children seeing themselves reflected in careers and cultures that they may not typically identify with. The current lack of diversity in accessible media, however, limits the potential for self-reflection from children of different socioeconomic, racial, and gender identity backgrounds. This isolates substantial sections of our population from experiencing these moments of recognition and inspiration. As scientists in a rapidly evolving field that requires diversity in perspective and ideas, it is incumbent upon us to innovate new ways to engage with these future generations in the pursuit of inspiring future earth scientists. Inspired by the work of others (e.g. Doc McStuffins, The Sandwich Swap) and through a successful crowdfunding campaign, I was able to develop a project which integrates children's love of adventure with foundational critical thinking skills. That project is MD and Finn. MD and Finn is a self-written/published children's book series which was developed to address the lack of diversity in children's literature. MD is a little girl who continuously explores, discovers, and builds the world around her with her best friend, Finn the fox. They encourage one another to ask questions, brainstorm, make mistakes, and learn from absolutely everything. While the primary goal of the series is to create a character in which young girls can see themselves solving problems, learning from mistakes, and enjoying the little pieces of science in daily life, as the project progresses, characters from different races, ethnicities, gender identities, religions, and disabilities are purposefully introduced. In bringing these books to life, I have been given the unique opportunity to regularly engage with classrooms and families who may be meeting an actual scientist for the very first time. For a few young girls, they may also finally be seeing just a little bit of themselves - in a lab coat

Outdoor adventure program builds confidence and competence to help new graduate RNs become "everyday" leaders at the point of care.

Science.gov (United States)

Greer-Day, Susan; Medland, Jackie; Watson, Lynn; Bojak, Sarah

2015-01-01

A nontraditional approach to leadership development promoted successful transition of new graduate RN residents to professional nurses. Utilizing an outdoor adventure program increased nurses' feelings of competence by boosting their confidence, facilitating an environment where leadership at the bedside became an ingrained part of their nursing practice. RN residents at a Midwestern medical center represented only 17% of the nursing population but reshaped the culture of the entire organization by becoming dynamic "everyday" leaders.

International Patterns of Practice in the Management of Radiation Therapy-induced Nausea and Vomiting

International Nuclear Information System (INIS)

Dennis, Kristopher; Zhang Liying; Lutz, Stephen; Baardwijk, Angela van; Linden, Yvette van der; Holt, Tanya; Arnalot, Palmira Foro; Lagrange, Jean-Léon; Maranzano, Ernesto; Liu, Rico; Wong, Kam-Hung; Wong, Lea-Choung; Vassiliou, Vassilios; Corn, Benjamin W.; De Angelis, Carlo; Holden, Lori; Wong, C. Shun; Chow, Edward

2012-01-01

Purpose: To investigate international patterns of practice in the management of radiation therapy-induced nausea and vomiting (RINV). Methods and Materials: Oncologists prescribing radiation therapy in the United States, Canada, The Netherlands, Australia, New Zealand, Spain, Italy, France, Hong Kong, Singapore, Cyprus, and Israel completed a Web-based survey that was based on 6 radiation therapy-only clinical cases modeled after the minimal-, low-, moderate-, and high-emetic risk levels defined in the antiemetic guidelines of the American Society of Clinical Oncology and the Multinational Association of Supportive Care in Cancer. For each case, respondents estimated the risks of nausea and vomiting separately and committed to an initial management approach. Results: In total, 1022 responses were received. Risk estimates and management decisions for the minimal- and high-risk cases varied little and were in line with guideline standards, whereas those for the low- and moderate-risk cases varied greatly. The most common initial management strategies were as follows: rescue therapy for a minimal-risk case (63% of respondents), 2 low-risk cases (56% and 80%), and 1 moderate-risk case (66%); and prophylactic therapy for a second moderate-risk case (75%) and a high-risk case (95%). The serotonin (5-HT) 3 receptor antagonists were the most commonly recommended prophylactic agents. On multivariate analysis, factors predictive of a decision for prophylactic or rescue therapy were risk estimates of nausea and vomiting, awareness of the American Society of Clinical Oncology antiemetic guideline, and European Society for Therapeutic Radiology and Oncology membership. Conclusions: Risk estimates and management strategies for RINV varied, especially for low- and moderate-risk radiation therapy cases. Radiation therapy-induced nausea and vomiting are under-studied treatment sequelae. New observational and translational studies are needed to allow for individual patient risk

International Patterns of Practice in the Management of Radiation Therapy-induced Nausea and Vomiting

Energy Technology Data Exchange (ETDEWEB)

Dennis, Kristopher; Zhang Liying [Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario (Canada); Lutz, Stephen [Blanchard Valley Health Systems, Findlay, Ohio (United States); Baardwijk, Angela van [Department of Radiation Oncology (MAASTRO Clinic), GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht (Netherlands); Linden, Yvette van der [Leiden University Medical Center, Leiden (Netherlands); Holt, Tanya [Radiation Oncology Mater Centre, Princess Alexandra Hospital, Brisbane (Australia); Arnalot, Palmira Foro [Parc de Salut Mar. Universitat Pompeu Fabra Barcelona (Spain); Lagrange, Jean-Leon [AP-HP Hopital Henri-Mondor, Universite Paris Est Creteil, Creteil (France); Maranzano, Ernesto [' S. Maria' Hospital, Terni (Italy); Liu, Rico [Queen Mary Hospital, Hong Kong (China); Wong, Kam-Hung [Queen Elizabeth Hospital, Hong Kong (Hong Kong); Wong, Lea-Choung [National University Cancer Institute (Singapore); Vassiliou, Vassilios [Bank of Cyprus Oncology Centre, Nicosia (Cyprus); Corn, Benjamin W. [Tel Aviv Medical Center, Tel Aviv (Israel); De Angelis, Carlo; Holden, Lori; Wong, C. Shun [Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario (Canada); Chow, Edward, E-mail: Edward.Chow@sunnybrook.ca [Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario (Canada)

2012-09-01

Purpose: To investigate international patterns of practice in the management of radiation therapy-induced nausea and vomiting (RINV). Methods and Materials: Oncologists prescribing radiation therapy in the United States, Canada, The Netherlands, Australia, New Zealand, Spain, Italy, France, Hong Kong, Singapore, Cyprus, and Israel completed a Web-based survey that was based on 6 radiation therapy-only clinical cases modeled after the minimal-, low-, moderate-, and high-emetic risk levels defined in the antiemetic guidelines of the American Society of Clinical Oncology and the Multinational Association of Supportive Care in Cancer. For each case, respondents estimated the risks of nausea and vomiting separately and committed to an initial management approach. Results: In total, 1022 responses were received. Risk estimates and management decisions for the minimal- and high-risk cases varied little and were in line with guideline standards, whereas those for the low- and moderate-risk cases varied greatly. The most common initial management strategies were as follows: rescue therapy for a minimal-risk case (63% of respondents), 2 low-risk cases (56% and 80%), and 1 moderate-risk case (66%); and prophylactic therapy for a second moderate-risk case (75%) and a high-risk case (95%). The serotonin (5-HT){sub 3} receptor antagonists were the most commonly recommended prophylactic agents. On multivariate analysis, factors predictive of a decision for prophylactic or rescue therapy were risk estimates of nausea and vomiting, awareness of the American Society of Clinical Oncology antiemetic guideline, and European Society for Therapeutic Radiology and Oncology membership. Conclusions: Risk estimates and management strategies for RINV varied, especially for low- and moderate-risk radiation therapy cases. Radiation therapy-induced nausea and vomiting are under-studied treatment sequelae. New observational and translational studies are needed to allow for individual patient risk

International experts' practice in the antibiotic therapy of infective endocarditis is not following the guidelines.

Science.gov (United States)

Tissot-Dupont, H; Casalta, J P; Gouriet, F; Hubert, S; Salaun, E; Habib, G; Fernandez-Gerlinger, M P; Mainardi, J L; Tattevin, P; Revest, M; Lucht, F; Botelho-Nevers, E; Gagneux-Brunon, A; Snygg-Martin, U; Chan, K L; Bishara, J; Vilacosta, I; Olmos, C; San Román, J A; López, J; Tornos, P; Fernández-Hidalgo, N; Durante-Mangoni, E; Utili, R; Paul, M; Baddour, L M; DeSimone, D C; Sohail, M R; Steckelberg, J M; Wilson, W R; Raoult, D

2017-10-01

The management of infective endocarditis (IE) may differ from international guidelines, even in reference centres. This is probably because most recommendations are not based on hard evidence, so the consensus obtained for the guidelines does not represent actual practices. For this reason, we aimed to evaluate this question in the particular field of antibiotic therapy. Thirteen international centres specialized in the management of IE were selected, according to their reputation, clinical results, original research publications and quotations. They were asked to detail their actual practice in terms of IE antibiotic treatment in various bacteriological and clinical situations. They were also asked to declare their IE-related in-hospital mortality for the year 2015. The global compliance with guidelines concerning antibiotic therapy was 58%, revealing the differences between theoretical 'consensus', local recommendations and actual practice. Some conflicts of interest were also probably expressed. The adherence to guidelines was 100% when the protocol was simple, and decreased with the seriousness of the situation (Staphylococus spp. 54%-62%) or in blood-culture-negative endocarditis (0%-15%) that requires adaptation to clinical and epidemiological data. Worldwide experts in IE management, although the majority of them were involved and co-signed the guidelines, do not follow international consensus guidelines on the particular point of the use of antibiotics. Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

'The adventure': Charles-Ferdinand Ramuz's extraordinary stroke diary.

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Bogousslavsky, J

2010-01-01

The famous Swiss writer Charles-Ferdinand Ramuz suffered a stroke at 65 years, which he called 'the adventure' or 'the accident'. He developed language disturbances suggesting crossed aphasia in a right hander with left hemiparesis. This uncommon pattern allowed him to continue to write his diary and to report his disturbances, with a unique depth and precision, especially for cognitive-emotional changes. Language and motor dysfunction recovered within a few weeks, but Ramuz complained of persisting emotional flattening alternating with irritability, fatigue, depression, anxiety, and concentration difficulty, which gave him the feeling to have become another person and to be inhabited by a stranger, whom he compared with devils. Ramuz fought several months to resume his literary activity, having the impression to have lost inspiration and creativity. However, the novels he wrote less than 6 months after stroke show no stylistic changes and have been found to be of the same quality as his previous production. Ramuz even 'used' his stroke experience in his work, in particular in a novel depicting an old man who has a stroke and dies of it. Ramuz's diary, with his own daily description of stroke features and consequences during acute and recovery phases, is a unique document in a writer of his importance, and provides invaluable information on subjective emotional and cognitive experience of stroke. Copyright (c) 2010 S. Karger AG, Basel.

When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council.

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Simpson, Eric L; Bruin-Weller, Marjolein; Flohr, Carsten; Ardern-Jones, Michael R; Barbarot, Sebastien; Deleuran, Mette; Bieber, Thomas; Vestergaard, Christian; Brown, Sara J; Cork, Michael J; Drucker, Aaron M; Eichenfield, Lawrence F; Foelster-Holst, Regina; Guttman-Yassky, Emma; Nosbaum, Audrey; Reynolds, Nick J; Silverberg, Jonathan I; Schmitt, Jochen; Seyger, Marieke M B; Spuls, Phyllis I; Stalder, Jean-Francois; Su, John C; Takaoka, Roberto; Traidl-Hoffmann, Claudia; Thyssen, Jacob P; van der Schaft, Jorien; Wollenberg, Andreas; Irvine, Alan D; Paller, Amy S

2017-10-01

Although most patients with atopic dermatitis (AD) are effectively managed with topical medication, a significant minority require systemic therapy. Guidelines for decision making about advancement to systemic therapy are lacking. To guide those considering use of systemic therapy in AD and provide a framework for evaluation before making this therapeutic decision with the patient. A subgroup of the International Eczema Council determined aspects to consider before prescribing systemic therapy. Topics were assigned to expert reviewers who performed a topic-specific literature review, referred to guidelines when available, and provided interpretation and expert opinion. We recommend a systematic and holistic approach to assess patients with severe signs and symptoms of AD and impact on quality of life before systemic therapy. Steps taken before commencing systemic therapy include considering alternate or concomitant diagnoses, avoiding trigger factors, optimizing topical therapy, ensuring adequate patient/caregiver education, treating coexistent infection, assessing the impact on quality of life, and considering phototherapy. Our work is a consensus statement, not a systematic review. The decision to start systemic medication should include assessment of severity and quality of life while considering the individual's general health status, psychologic needs, and personal attitudes toward systemic therapies. Copyright © 2017 American Academy of Dermatology, Inc. All rights reserved.

Proceedings from an international conference on ablation therapy for Barrett's mucosa: Brittany, France, 31 August - 2 September 1997.

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Bremner, C G; Demeester, T R

2017-11-01

The increasing incidence of adenocarcinoma of the lower esophagus and cardia arising in Barrett's metaplastic epithelium continues to be of great concern because medical and surgical efforts to reverse the process have been disappointing. A potential answer to the problem is removal of the metaplastic epithelium. Modern technology has introduced physical and chemical modalities which facilitate ablation of the neo-epithelium endoscopically. These techniques have been used in several centers, and preliminary results are encouraging. This report summarizes the proceedings of an international symposium on ablative therapy held in Brittany, France in August 1997.Twenty-eight speakers contributed to the talks on the pathology, pathogenesis, current therapy experimental studies and clinical experience of ablation of Barrett's esophagus. © 1998 International Society for Diseases of the Esophagus/Harcourt Brace & Co. Ltd.

Modern Radiation Therapy for Extranodal Lymphomas: Field and Dose Guidelines From the International Lymphoma Radiation Oncology Group

Energy Technology Data Exchange (ETDEWEB)

Yahalom, Joachim, E-mail: yahalomj@mskcc.org [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Illidge, Tim [Institute of Cancer Sciences, University of Manchester, Manchester Academic Health Sciences Centre, The Christie National Health Service Foundation Trust, Manchester (United Kingdom); Specht, Lena [Department of Oncology and Hematology, Rigshospitalet, University of Copenhagen, Copenhagen (Denmark); Hoppe, Richard T. [Department of Radiation Oncology, Stanford University, Palo Alto, California (United States); Li, Ye-Xiong [Department of Radiation Oncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (China); Tsang, Richard [Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario (Canada); Wirth, Andrew [Division of Radiation Oncology, Peter MacCallum Cancer Institute, St. Andrews Place, East Melbourne (Australia)

2015-05-01

Extranodal lymphomas (ENLs) comprise about a third of all non-Hodgkin lymphomas (NHL). Radiation therapy (RT) is frequently used as either primary therapy (particularly for indolent ENL), consolidation after systemic therapy, salvage treatment, or palliation. The wide range of presentations of ENL, involving any organ in the body and the spectrum of histological sub-types, poses a challenge both for routine clinical care and for the conduct of prospective and retrospective studies. This has led to uncertainty and lack of consistency in RT approaches between centers and clinicians. Thus far there is a lack of guidelines for the use of RT in the management of ENL. This report presents an effort by the International Lymphoma Radiation Oncology Group (ILROG) to harmonize and standardize the principles of treatment of ENL, and to address the technical challenges of simulation, volume definition and treatment planning for the most frequently involved organs. Specifically, detailed recommendations for RT volumes are provided. We have applied the same modern principles of involved site radiation therapy as previously developed and published as guidelines for Hodgkin lymphoma and nodal NHL. We have adopted RT volume definitions based on the International Commission on Radiation Units and Measurements (ICRU), as has been widely adopted by the field of radiation oncology for solid tumors. Organ-specific recommendations take into account histological subtype, anatomy, the treatment intent, and other treatment modalities that may be have been used before RT.

Modern Radiation Therapy for Extranodal Lymphomas: Field and Dose Guidelines From the International Lymphoma Radiation Oncology Group

International Nuclear Information System (INIS)

Yahalom, Joachim; Illidge, Tim; Specht, Lena; Hoppe, Richard T.; Li, Ye-Xiong; Tsang, Richard; Wirth, Andrew

2015-01-01

Extranodal lymphomas (ENLs) comprise about a third of all non-Hodgkin lymphomas (NHL). Radiation therapy (RT) is frequently used as either primary therapy (particularly for indolent ENL), consolidation after systemic therapy, salvage treatment, or palliation. The wide range of presentations of ENL, involving any organ in the body and the spectrum of histological sub-types, poses a challenge both for routine clinical care and for the conduct of prospective and retrospective studies. This has led to uncertainty and lack of consistency in RT approaches between centers and clinicians. Thus far there is a lack of guidelines for the use of RT in the management of ENL. This report presents an effort by the International Lymphoma Radiation Oncology Group (ILROG) to harmonize and standardize the principles of treatment of ENL, and to address the technical challenges of simulation, volume definition and treatment planning for the most frequently involved organs. Specifically, detailed recommendations for RT volumes are provided. We have applied the same modern principles of involved site radiation therapy as previously developed and published as guidelines for Hodgkin lymphoma and nodal NHL. We have adopted RT volume definitions based on the International Commission on Radiation Units and Measurements (ICRU), as has been widely adopted by the field of radiation oncology for solid tumors. Organ-specific recommendations take into account histological subtype, anatomy, the treatment intent, and other treatment modalities that may be have been used before RT

Adventures of Geo: Using comics as a learning tool

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Lee, K. K. M.; Wallenta, A.

2015-12-01

Illustrations are a good way to visualize what is not readily seen. To take this medium a step further, we use illustrations in the form of comics as a way to teach Earth science concepts. The comic book format lends itself to engaging reading for young and old alike and has been used recently by the American Physical Society (APS) and by NASA as an outreach teaching tool. Due to their sequential nature, comic books make it easy for readers to follow a story and grasp concepts that are covered. The limited text in each panel can also help those where reading is a challenge or for those who become nervous and/or discouraged with long text passages. The illustrations also add visual clues that can aid in understanding the concepts being laid out. In the second installment of "Adventures of Geo," we use the comic book format to introduce the Moon, its formation, evolution, orbit and its interplay with Earth. The exploration of such faraway places is readily disseminated to the public through such a graphical approach. The comic books are aimed at middle school students in the New Haven Public Schools (NHPS) where Earth Science topics are covered in the curriculum.

Liver cancer and selective internal radiation therapy

International Nuclear Information System (INIS)

Sutton, C.

2002-01-01

Liver cancer is the biggest cancer-related killer of adults in the world. Liver cancer can be considered as two types: primary and secondary (metastatic). Selective Internal Radiation Therapy (SIRT) is a revolutionary treatment for advanced liver cancer that utilises new technologies designed to deliver radiation directly to the site of tumours. SIRT, on the other hand, involves the delivery of millions of microscopic radioactive spheres called SIR-Spheres directly to the site of the liver tumour/s, where they selectively irradiate the tumours. The anti-cancer effect is concentrated in the liver and there is little effect on cancer at other sites such as the lungs or bones. The SIR-Spheres are delivered through a catheter placed in the femoral artery of the upper thigh and threaded through the hepatic artery (the major blood vessel of the liver) to the site of the tumour. The microscopic spheres, each approximately 35 microns (the size of four red blood cells or one-third the diameter of a strand of hair), are bonded to yttrium-90 (Y-90), a pure beta emitter with a physical half-life of 64.1 hours (about 2.67 days). The microspheres are trapped in the tumour's vascular bed, where they destroy the tumour from inside. The average range of the radiation is only 2.5 mm, so it is wholly contained within the patient's body; after 14 days, only 2.5 percent of the radioactive activity remains. The microspheres are suspended in water for injection. The vials are shipped in lead shields for radiation protection. Treatment with SIR-Spheres is generally not regarded as a cure, but has been shown to shrink the cancer more than chemotherapy alone. This can increase life expectancy and improve quality of life. On occasion, patients treated with SIR-Spheres have had such marked shrinkage of the liver cancer that the cancer can be surgically removed at a later date. This has resulted in a long-term cure for some patients. SIRTeX Medical Limited has developed three separate cancer

Secrets of the Sediments: Using ANDRILL's Scientific Adventure on Ice to Transfer Climate Change Science to K-12 Audiences

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Huffman, L. T.; Dahlman, L.; Frisch-Gleason, R.; Harwood, D.; Pound, K.; Rack, F.; Riesselman, C.; Trummel, E.; Tuzzi, E.; Winter, D.

2008-12-01

Antarctica's harsh environment and the compelling story of living and working there, provides the backdrop for hooking the interest of young learners on science research and the nature of science. By using the adventure stories of today's researcher-explorers, teachers accompanying the ANDRILL team have taken the technical science of drilling rock cores to understand the history of climate change and the advance and retreat of the Antarctic ice sheet, and translated it for non-technical audiences from K-12 school children, to adult community groups. In order to understand the important issues surrounding global climate change, members of the public need access to accurate and relevant information, high quality educational materials, and a variety of learning opportunities in different learning environments. By taking lessons learned from early virtual polar adventure learning expeditions like Will Steger's Trans-Antarctic Expedition, coupled with educators-in-the-field programs like TEA (Teachers Experiencing Antarctica and the Arctic), ARMADA and Polar Trec, ANDRILL's Education and Outreach Program has evolved into successful and far-reaching integrated education projects including 1) the ARISE (ANDRILL Research Immersion for Science Educators) Program, 2) Climate Change Student Summits, 3) the development of Flexhibit (flexible exhibit) teaching resources, 4) virtual online learning communities, and 5) partnering young researchers with teachers and classrooms. Formal evaluations indicate lasting interest in science studies on the part of students and an increase in teachers' scientific background knowledge.

An integrated service digital network (ISDN)-based international telecommunication between Samsung Medical Center and Hokkaido University using telecommunication helped radiotherapy planning and information system (THERAPIS)

International Nuclear Information System (INIS)

Huh, S.J.; Kim, D.Y.; Ahn, Y.C.; Choi, D.; Shirato, H.; Hashimoto, S.; Shimizu, S.; Miyasaka, K.; Mizuno, J.

2000-01-01

This study introduces the integrated service digital network (ISDN)-based international teleradiotherapy system (THERAPIS) in radiation oncology between hospitals in Seoul, South Korea and in Sapporo, Japan. THERAPIS has the following functions: (1) exchange of patient's image data, (2) real-time teleconference, and (3) communication of the treatment planning, dose calculation and distribution, and of portal verification images between the remote hospitals. Our preliminary results of applications on eight patients demonstrated that the international telecommunication using THERAPIS was clinically useful and satisfactory with sufficient bandwidth for the transfer of patient data for clinical use in radiation oncology. (author)

An integrated service digital network (ISDN)-based international telecommunication between Samsung Medical Center and Hokkaido University using telecommunication helped radiotherapy planning and information system (THERAPIS).

Science.gov (United States)

Huh, S J; Shirato, H; Hashimoto, S; Shimizu, S; Kim, D Y; Ahn, Y C; Choi, D; Miyasaka, K; Mizuno, J

2000-07-01

This study introduces the integrated service digital network (ISDN)-based international teleradiotherapy system (THERAPIS) in radiation oncology between hospitals in Seoul, South Korea and in Sapporo, Japan. THERAPIS has the following functions: (1) exchange of patient's image data, (2) real-time teleconference, and (3) communication of the treatment planning, dose calculation and distribution, and of portal verification images between the remote hospitals. Our preliminary results of applications on eight patients demonstrated that the international telecommunication using THERAPIS was clinically useful and satisfactory with sufficient bandwidth for the transfer of patient data for clinical use in radiation oncology.

Effectiveness of Group Activity Play Therapy on Internalizing and Externalizing Behavior Problems of Preadolescent Orphans in Uganda

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Ojiambo, Deborah

2011-01-01

This pilot study investigated the impact of group activity play therapy (GAPT) on displaced orphans aged 10 to 12 years living in a large children's village in Uganda. Teachers and housemothers identified 60 preadolescents exhibiting clinical levels of internalizing and externalizing behavior problems. The participants' ethnicity was African and…

Impact of the Extended Learning Opportunities Summer Adventures in Learning (ELO SAIL) Program on Student Academic Performance: Part 1, Results from Fall 2012 to Fall 2015

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Cooper-Martin, Elizabeth; Wolanin, Natalie; Jang, Seong; Modarresi, Shahpar; Zhao, Huafang

2016-01-01

Extended Learning Opportunities Summer Adventures in Learning (ELO SAIL) is a Montgomery County Public Schools summer program for students in all Title I elementary schools; it targets students who will be in kindergarten-Grade 2 in the fall following the program. This report analyzed demographic characteristics of attendees and the impact of the…

International leadership in nursing

Directory of Open Access Journals (Sweden)

Ged F. Williams

2013-12-01

Full Text Available As the global community becomes overwhelmed by conflict, threat and scandal in many countries it is heartening to find that many of us can still find opportunity to give generously to the betterment of humanity.Recently we have both had our share of fun and excitement working and learning in various regions of the world, Ged in the Middle East and Africa and Wilson in the USA, The Netherlands and Brazil.We are often asked “how do you develop an international perspective”? The short answer is that it is an insidious accident sometimes, however like many things a deeper analysis reveals a journey that is often planned and other times blessed by unexpected surprises. However a sense of openness, generosity and adventure is always necessary to maximise every opportunity.Among other things, Ged allocated time to travel and to visit hospitals and nurses in other parts of Australia and the world, listening to people’s stories, dreams, and aspirations and providing reciprocal encouragement and fellowship, often through interpreters. (Rev Cuid 2013; 4(1:433-6.

Music therapy career aptitude and generalized self-efficacy in music therapy students.

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Lim, Hayoung A; Befi, Cathy M

2014-01-01

While the Music Therapy Career Aptitude Test (MTCAT) provides a measure of student aptitude, measures of perceived self-efficacy may provide additional information about a students' suitability for a music therapy career. As a first step in determining whether future studies examining combined scores from the MTCAT and the Generalized Self-Efficacy (GSE) scale would be useful to help predict academic success in music therapy, we explored the internal reliability of these two measures in a sample of undergraduate students, and the relationship (concurrent validity) of the measures to one another. Eighty undergraduate music therapy students (14 male; 66 female) completed the MTCAT and GSE. To determine internal reliability we conducted tests of normality and calculated Cronbach's Coefficient Alpha for each measure. Pearson correlation coefficients were calculated to ascertain the strength of the relationship between the MTCAT and GSE. MTCAT scores were normally distributed and had high internal consistency (Cronbach's α = 0.706). GSE scores were not normally distributed, but had high internal consistency (Cronbach's α = 0.748). The correlation coefficient analysis revealed that MTCAT and GSE scores were moderately correlated ((r = 0.426, p music therapy students; however, a more complete picture of student suitability for music therapy may be determined by administering the GSE alongside the MTCAT. Future studies are needed to determine whether combined MTCAT and GSE scores can be used to predict student success in an undergraduate music therapy program. © the American Music Therapy Association 2014. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Third-line Targeted Therapy in Metastatic Renal Cell Carcinoma: Results from the International Metastatic Renal Cell Carcinoma Database Consortium.

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Wells, J Connor; Stukalin, Igor; Norton, Craig; Srinivas, Sandy; Lee, Jae Lyun; Donskov, Frede; Bjarnason, Georg A; Yamamoto, Haru; Beuselinck, Benoit; Rini, Brian I; Knox, Jennifer J; Agarwal, Neeraj; Ernst, D Scott; Pal, Sumanta K; Wood, Lori A; Bamias, Aristotelis; Alva, Ajjai S; Kanesvaran, Ravindran; Choueiri, Toni K; Heng, Daniel Y C

2017-02-01

The use of third-line targeted therapy (TTT) in metastatic renal cell carcinoma (mRCC) is not well characterized and varies due to the lack of robust data to guide treatment decisions. This study examined the use of third-line therapy in a large international population. To evaluate the use and efficacy of targeted therapy in a third-line setting. Twenty-five international cancer centers provided consecutive data on 4824 mRCC patients who were treated with an approved targeted therapy. One thousand and twelve patients (21%) received TTT and were included in the analysis. Patients were analyzed for overall survival (OS) and progression-free survival using Kaplan-Meier curves, and were evaluated for overall response. Cox regression analyses were used to determine the statistical association between OS and the six factors included in the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) prognostic model. Subgroup analysis was performed on patients stratified by their IMDC prognostic risk status. Everolimus was the most prevalent third-line therapy (27.5%), but sunitinib, sorafenib, pazopanib, temsirolimus, and axitinib were all utilized in over ≥9% of patients. Patients receiving any TTT had an OS of 12.4 mo, a progression-free survival of 3.9 mo, and 61.1% of patients experienced an overall response of stable disease or better. Patients not receiving TTT had an OS of 2.1 mo. Patients with favorable- (7.2%) or intermediate-risk (65.3%) disease had the highest OS with TTT, 29.9 mo and 15.5 mo, respectively, while poor-risk (27.5%) patients survived 5.5 mo. Results are limited by the retrospective nature of the study. TTT remains highly heterogeneous. The IMDC prognostic criteria can be used to stratify third-line patients. TTT use in favorable- and intermediate-risk patients was associated with the greatest OS. Patients with favorable- and intermediate-prognostic criteria disease treated with third-line targeted therapy have an associated

Gaps in Radiation Therapy Awareness: Results From an Educational Multi-institutional Survey of US Internal Medicine Residents.

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Shaverdian, Narek; Yoo, Sun Mi; Cook, Ryan; Chang, Eric M; Jiang, Naomi; Yuan, Ye; Sandler, Kiri; Steinberg, Michael; Lee, Percy

2017-08-01

Internists and primary care providers play a growing role in cancer care. We therefore evaluated the awareness of radiation therapy in general and specifically the clinical utility of stereotactic body radiation therapy (SBRT) for early-stage non-small cell lung cancer (NSCLC) among current US internal medicine residents. A web-based institutional review board-approved multi-institutional survey was distributed to US internal medicine residency programs. The survey evaluated trainee demographic characteristics, baseline radiation oncology awareness, knowledge of the role of SBRT for early-stage NSCLC, and whether the survey successfully improved awareness. Thirty US internal medicine programs participated, with an overall participant response rate of 46% (1177 of 2551). Of the trainees, 93% (n=1076) reported no radiation oncology education in their residency, 39% (n=452) reported confidence in knowing when to consult radiation oncology in an oncologic emergency, and 26% (n=293) reported confidence in knowing when to consult radiation oncology in the setting of a newly diagnosed cancer. Of the participants, 76% (n=850) correctly identified that surgical resection is the standard treatment in operable early-stage NSCLC, but only 50% (n=559) of participants would recommend SBRT to a medically inoperable patient, followed by 31% of participants (n=347) who were unsure of the most appropriate treatment, and 10% (n=117) who recommended waiting to offer palliative therapy. Ninety percent of participants (n=1029) agreed that they would benefit from further training on when to consult radiation oncology. Overall, 96% (n=1072) indicated that the survey increased their knowledge and awareness of the role of SBRT. The majority of participating trainees received no education in radiation oncology in their residency, reported a lack of confidence regarding when to consult radiation oncology, and overwhelmingly agreed that they would benefit from further training. These findings

Estimated Internal and External Radiation Exposure of Caregivers of Patients With Pediatric Neuroblastoma Undergoing 131I Metaiodobenzylguanidine Therapy: A Prospective Pilot Study.

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Han, Sangwon; Yoo, Seon Hee; Koh, Kyung-Nam; Lee, Jong Jin

2017-04-01

Current recommendations suggest that family members should participate in the care of children receiving in-hospital I metaiodobenzylguanidine (MIBG) therapy for neuroblastoma. The present study aimed to measure the external radiation exposure and estimate the internal radiation exposure of caregivers during the hospital stay for I MIBG therapy. Caregivers received radiation safety instructions and a potassium iodide solution for thyroid blockade before patient admission. External radiation exposure was determined using a personal pocket dosimeter. Serial 24-hour urine samples were collected from caregivers during the hospital stay. Estimated internal radiation exposure was calculated based on the urine activity. Twelve cases (mean age, 6.2 ± 3.5 years; range, 2-13 years) were enrolled. The mean administered activity was 233.3 ± 74.9 (range, 150.0-350.0) mCi. The mean external radiation dose was 5.8 ± 7.2 (range, 0.8-19.9) mSv. Caregivers of children older than 4 years had significantly less external radiation exposure than those of children younger than 4 years (1.9 ± 1.0 vs 16.4 ± 5.0 mSv; P = 0.012). The mean estimated internal radiation dose was 11.3 ± 10.2 (range, 1.0-29.8) μSv. Caregivers receive both external and internal radiation exposure while providing in-hospital care to children receiving I MIBG therapy for neuroblastoma. However, the internal radiation exposure was negligible compared with the external radiation exposure.

Adventures in public data.

Science.gov (United States)

Zaharevitz, Dan W

2011-10-14

This article contains the slides and transcript of a talk given by Dan Zaharevitz at the "Visions of a Semantic Molecular Future" symposium held at the University of Cambridge Department of Chemistry on 2011-01-19. A recording of the talk is available on the University Computing Service's Streaming Media Service archive at http://sms.cam.ac.uk/media/1095515 (unfortunately the first part of the recording was corrupted, so the talk appears to begin at slide 6, 'At a critical time'). We believe that Dan's message comes over extremely well in the textual transcript and that it would be poorer for serious editing. In addition we have added some explanations and references of some of the concepts in the slides and text. (Charlotte Bolton; Peter Murray-Rust, University of Cambridge) EDITORIAL PREFACE: The following paper is part of a series of publications which arose from a Symposium held at the Unilever Centre for Molecular Informatics at the University of Cambridge to celebrate the lifetime achievements of Peter Murray-Rust. One of the motives of Peter's work was and is a better transport and preservation of data and information in scientific publications. In both respects the following publication is relevant: it is about public data and their representation, and the publication represents a non-standard experiment of transporting the content of the scientific presentation. As you will see, it consists of the original slides used by Dan Zaharevitz in his talk "Adventures in Public Data" at the Unilever Centre together with a diligent transcript of his speech. The transcribers have gone through great effort to preserve the original spirit of the talk by preserving colloquial language as it is used at such occasions. For reasons known to us, the original speaker was unable to submit the manuscript in a more conventional form. We, the Editors, have discussed in depth whether such a format is suitable for a scientific journal. We have eventually decided to publish this

Hoarseness in School-Aged Children and Effectiveness of Voice Therapy in International Classification of Functioning Framework.

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Akın Şenkal, Özgül; Özer, Cem

2015-09-01

The hoarseness in school-aged children disrupts the educational process because it affects the social progress, communication skills, and self-esteem of children. Besides otorhinolaryngological examination, the first treatment option is voice therapy when hoarseness occurs. The aim of the study was to determine the factors increasing the hoarseness in school-aged children by parental interview and to know preferable voice therapy on school-aged children within the frame of International Classification of Functioning (ICF). Retrospective analysis of data gathered from patient files. A total of 75 children (56 boys and 19 girls) were examined retrospectively. The age range of school-aged children is 7-14 years and average is 10.86 ± 2.51. A detailed history was taken from parents of children involved in this study. Information about vocal habits of children was gathered within the frame of ICF and then the voice therapies of children were started by scheduling appointments by an experienced speech-language pathologist. The differences between before and after voice therapy according to applied voice therapy methods, statistically significant differences were determined between maximum phonation time values and s/z rate. The relationship between voice therapy sessions and s/z rate with middle degree significance was found with physiological voice therapy sessions. According to ICF labels, most of voice complaints are matching with "body functions" and "activity and limitations." The appropriate voice therapy methods for hoarseness in school-aged children must be chosen and applied by speech-language therapists. The detailed history, which is received from family during the examination, within the frame of ICF affects the processes of choosing the voice therapy method and application of them positively. Child's family is very important for a successful management. Copyright © 2015 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

Impact Of Equestrian Tourism On The Environment

OpenAIRE

Ioan Petroman

2015-01-01

Considereda sub-sector of horse raisin units, equestrian tourism is a form of moderntourism very popular among the young people as both an entertainingrecreational and adventure activity and a form of animal therapy in thetreatment and rehabilitation of autistic children; it is also a sub-type ofrural tourism, adventure tourism, or ecological tourism. Equestrian tourismpracticed without management strategies can have both positive and negativeeffects on the environment: it can affect roads by...

World Radiopharmaceutical Therapy Council: A report on the 5th International Radiopharmaceutical Therapy Colloquium and the Final Planning Meeting of the World Radiopharmaceutical Therapy Council held at Santiago, Chile, 29 September, 2002

International Nuclear Information System (INIS)

Turner, J.V.

2003-01-01

Full text: The 5th International Radiopharmaceutical Therapy Colloquium was held on 29th October 2002 as a pre-congress meeting of the World Federation of Nuclear Medicine and Biology Congress in Santiago, Chile. Work-in-Progress research papers were presented by leaders in the field of therapeutic nuclear oncology. Speakers gave untitled presentations without abstracts and reported data from studies performed only days or weeks before the meeting. Such cutting edge research presentations stimulated lively discussion which also addressed the problems encountered and ways in which they may be circumvented. Radioimmunotherapy of haematological malignancy was discussed by Greg Wiseman of the Mayo Clinic, and Thomas Behr of the University of Marburg. Radiopeptide therapy of neuroendocrine tumours was presented by Larry Kvols from the University of Florida, and locoregional therapy of glioma was presented by John Buscombe of the Royal Free Hospital, London. All speakers reported encouraging clinical results with objective tumour responses, increased survival and improved quality of life, which encourages wider clinical application of these novel radiopharmaceutical therapies. The Round Table Discussion on clinical applications of Rhenium-188 radiopharmaceuticals was chaired by Russ Knapp from Oak Ridge National Laboratory and Hans Biersack of the University of Bonn. Following an outline of current developments by Russ Knapp preliminary results of clinical trials were presented for discussion. Hans Biersack, Javier Gaudiano from Montevideo and Achim Kropp from Dresden reported effective palliation of painful skeletal metastases with 188Re-HEDP. Ajit Padhy gave an update of the IAEA multicentre trial of intrahepatic arterial 188Re-Lipiodol therapy of hepatocellular carcinoma and Harvey Turner reported preliminary results in hepatoma patients using an alternative kit formulation of 188Re-Lipiodol in Fremantle. Early experience with Rhenium 188 in the prevention of re

Negative-pressure wound therapy with instillation: international consensus guidelines.

Science.gov (United States)

Kim, Paul J; Attinger, Christopher E; Steinberg, John S; Evans, Karen K; Lehner, Burkhard; Willy, Christian; Lavery, Larry; Wolvos, Tom; Orgill, Dennis; Ennis, William; Lantis, John; Gabriel, Allen; Schultz, Gregory

2013-12-01

Negative-pressure wound therapy with instillation is increasingly utilized as an adjunct therapy for a wide variety of wounds. Despite its growing popularity, there is a paucity of evidence and lack of guidance to provide effective use of this therapy. A panel of experts was convened to provide guidance regarding the appropriate use of negative-pressure wound therapy with instillation. A face-to-face meeting was held where the available evidence was discussed and individual clinical experience with this therapy was shared. Follow-up communication among the panelists continued until consensus was achieved. The final consensus recommendations were derived through more than 80 percent agreement among the panelists. Nine consensus statements were generated that address the appropriate use of negative-pressure wound therapy with instillation. The question of clinical effectiveness of this therapy was not directly addressed by the consensus panel. This document serves as preliminary guidelines until more robust evidence emerges that will support or modify these consensus recommendations.

Current perspectives of radiation therapy. History of radiation therapy

International Nuclear Information System (INIS)

Itami, Jun

2011-01-01

More than 100 years have passed since the discovery of X-Strahlen by Roentgen. The history of radiation therapy has evolved under mutual stimulating relationships of the external beam radiation therapy by X-ray tubes and accelerators, and the internal radiation therapy employing radium and other radionuclides. The currently employed technologies in radiation therapy have its origin already till nineteen sixties and the development of physics and engineering have realized the original concept. (author)

Gender Trouble in Conan Doyle’s “The Adventure of the Solitary Cyclist”

Directory of Open Access Journals (Sweden)

Kitsi-Mitakou Katerina

2016-12-01

Full Text Available Although the Victorian period was a time when the sexes were assigned distinct and complementary roles, these rigid gender-role divisions between the two sexes were beginning to dissolve as the nineteenth century was drawing to its close. Among the various factors that contributed to bringing the two genders closer was the cycling boom of the 1890s, and the first-wave feminists embraced the bicycle as a freedom machine and symbol of emancipation. Despite the fact, though, that cycling functioned at first as a gender equaliser, , it eventually segregated the sexes, as social norms promoted the idea of gendered cycling and enforced a model of domesticated or feminised cycling for women. This essay aims to explore how Arthur Conan Doyle’s 1895 story “The Adventure of the Solitary Cyclist” reflects this complicated impact that cycling had on gender segregation and the possibilities it offered for gender fusion as well as the alternative expressions of sexuality it enabled.

Assessment techniques for a learning-centered curriculum: evaluation design for adventures in supercomputing

Energy Technology Data Exchange (ETDEWEB)

Helland, B. [Ames Lab., IA (United States); Summers, B.G. [Oak Ridge National Lab., TN (United States)

1996-09-01

As the classroom paradigm shifts from being teacher-centered to being learner-centered, student assessments are evolving from typical paper and pencil testing to other methods of evaluation. Students should be probed for understanding, reasoning, and critical thinking abilities rather than their ability to return memorized facts. The assessment of the Department of Energy`s pilot program, Adventures in Supercomputing (AiS), offers one example of assessment techniques developed for learner-centered curricula. This assessment has employed a variety of methods to collect student data. Methods of assessment used were traditional testing, performance testing, interviews, short questionnaires via email, and student presentations of projects. The data obtained from these sources have been analyzed by a professional assessment team at the Center for Children and Technology. The results have been used to improve the AiS curriculum and establish the quality of the overall AiS program. This paper will discuss the various methods of assessment used and the results.

El Arte de Aprender: Una Aventura Cooperativa. Un guia de recursos para trabajar con ninos jovenes. (Learning: A Cooperative Adventure. A Resource Guide for Working with Young Children.)

Science.gov (United States)

Arizona State Dept. of Education, Phoenix.

Due to the large numbers of children from Spanish-speaking homes, many districts send both English and Spanish written communication to parents and community members. Therefore this booklet, a Spanish translation of "Learning: A Cooperative Adventure" (ED 119 868), was prepared to provide parents and preschool and kindergarten staff members with…

"Once more a kingly quest": Fan games and the classic adventure genre

Directory of Open Access Journals (Sweden)

Anastasia Marie Salter

2009-03-01

Full Text Available The classic adventure games—part of the earliest traditions of interactive narrative—have not disappeared, although they no longer occupy space on the shelves at the local computer store. Even as changing hardware and operating systems render these games of the 1980s and 1990s literally unplayable without emulating the computer systems of the past, fans are keeping these stories alive. Authorship of these games has changed hands: it is now under the control of the fans, the former and current players. Through the online sharing of fan-created game design tool sets and of the fan-created games themselves, these new coauthors create a haven to revisit these decades-old games using fresh eyes and fresh systems. The products of these folk art–reminiscent efforts also offer a venue to reconsider video game fandom in light of genres. They also allow us to understand these "personal games," productions of one or more people that are not intended for commercial sale, as carrying the heritage of the classic era forward into the next generation of gaming.

OEI, GTTP and Adventurers of the Universe: training teachers and disseminating science in the South of Brazil

Science.gov (United States)

Pavani, D. B.; Saraiva, M. F. O.; Dottori, H.

2014-10-01

Itinerant Educative Observatory (OEI) is a permanent program of our Department of Astronomy since 1999. It aims to lecture Astronomy to teachers of fundamental and middle levels, using attractive resources such as telescopic observations, audiovisuals, and multimedia. The training courses are requested by different cities of Rio Grande do Sul and nearby states and are organized by a local committee of the requesting city. In 2014, with federal funds, we are uniting efforts with other extension project: the Galileo Teacher Training Program (GTTP). This is an international program developed to train teachers in the effective use of astronomy education tools and resources in their science classes. The program, that is a legacy of IYA2009, aims to create a worldwide network of Galileo Ambassadors the promoters of the training workshops and Galileo Teachers the teachers who bring the learned methodologies into classroom. To supplement these activities, we initiated a new program in 2012 called Adventurers of the Universe. University professors, undergraduates students and teachers of high-school and elementary school of social vulnerable communities develop transdiciplinary didactic sequences where Astronomy is the central focus to motivate different processes of teaching and learning, considering different learning levels, designed for direct use in the classroom. The objective of the program is to contribute to the didactic transposition through the discussion about how to relate astronomy with other science and non-science disciplines. In 2012 we collaborated with 20 teachers of one school, and 900 students. In 2013, the collaborations were expanded to include teachers and students of 3 other schools.

Sustaining International Partnerships: The European Master of Science Program In Occupational Therapy: A Case Study

DEFF Research Database (Denmark)

Ilott, Irene; Kottorp, Anders; la Cour, Karen

2013-01-01

Abstract International partnerships are a mechanism for supporting the academic development of occupational therapy and promoting cultural competence. This case study describes the factors that have helped to sustain a post-qualifying programme implemented by five higher education institutions...... comprises students from an average of eight countries to optimize inter-cultural dialogue. Four factors support sustainability. These are 1) supportive professional European networks; 2) timeliness and alignment with European higher education policy; 3) partnership structures and processes that emphasize...

Outbreak of Rickettsia africae infections in participants of an adventure race in South Africa.

Science.gov (United States)

Fournier, P E; Roux, V; Caumes, E; Donzel, M; Raoult, D

1998-08-01

African tick-bite fever, caused by Rickettsia africae and transmitted by Amblyomma ticks, is an emerging rickettsiosis in southern Africa. Because of increased tourism to this area, several cases in tourists have been reported recently. We report 13 cases of R. africae infection diagnosed in France that occurred in competitors returning from an adventure race in South Africa and compare our data with previously reported findings. Most of our patients presented with fever, headache, multiple inoculation eschars, and regional lymphadenopathies, but only 15.4% had a cutaneous rash. Diagnosis was confirmed either by isolation of R. africae from an eschar biopsy specimen or by serological methods, including cross-adsorption between R. africae and Rickettsia conorii. The purpose of this study was to raise physicians' awareness of R. africae infections in an attempt to facilitate the rapid diagnosis and treatment of imported African tick-bite fever in developed countries.

The Process for the Formulation of the International Telehealth Position Statement for Occupational Therapy

Science.gov (United States)

JACOBS, KAREN; CASON, JANA; MCCULLOUGH, ANN

2015-01-01

The World Federation of Occupational Therapists (WFOT) consists of 84 member organizations representing over 420,000 occupational therapists internationally (WFOT, 2014). In 2014, WFOT published the WFOT Telehealth Position Statement on the use of telehealth in occupational therapy. The process for the formulation of the official document involved reviewing WFOT member organizations’ telehealth position statements and data collected from a survey sent to member organizations’ delegates in April 2014. Qualitative data from 39 countries yielded factors to consider in five key areas: licensure/registration requirements, the cost of technology, privacy and security, reimbursement/payment models, and other issues (e.g., need for collaboration/transfer of knowledge, client selection, provider competencies, standard of care). The WFOT Telehealth Position Statement addressed each of these areas. The collaborative effort resulting in the development of the WFOT Telehealth Position Statement serves as a model for other international organizations. PMID:27563380

Adventures in public data

Directory of Open Access Journals (Sweden)

Zaharevitz Dan W

2011-10-01

Full Text Available Abstract This article contains the slides and transcript of a talk given by Dan Zaharevitz at the "Visions of a Semantic Molecular Future" symposium held at the University of Cambridge Department of Chemistry on 2011-01-19. A recording of the talk is available on the University Computing Service's Streaming Media Service archive at http://sms.cam.ac.uk/media/1095515 (unfortunately the first part of the recording was corrupted, so the talk appears to begin at slide 6, 'At a critical time'. We believe that Dan's message comes over extremely well in the textual transcript and that it would be poorer for serious editing. In addition we have added some explanations and references of some of the concepts in the slides and text. (Charlotte Bolton; Peter Murray-Rust, University of Cambridge Editorial preface The following paper is part of a series of publications which arose from a Symposium held at the Unilever Centre for Molecular Informatics at the University of Cambridge to celebrate the lifetime achievements of Peter Murray-Rust. One of the motives of Peter's work was and is a better transport and preservation of data and information in scientific publications. In both respects the following publication is relevant: it is about public data and their representation, and the publication represents a non-standard experiment of transporting the content of the scientific presentation. As you will see, it consists of the original slides used by Dan Zaharevitz in his talk "Adventures in Public Data" at the Unilever Centre together with a diligent transcript of his speech. The transcribers have gone through great effort to preserve the original spirit of the talk by preserving colloquial language as it is used at such occasions. For reasons known to us, the original speaker was unable to submit the manuscript in a more conventional form. We, the Editors, have discussed in depth whether such a format is suitable for a scientific journal. We have eventually

"My petticoat encumbrances"; the 'female adventurer' and the north

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Kathryn Walchester

2014-08-01

Full Text Available Focussing on the northern travelogues of two women travellers from the late nineteenth century, Ethel Brilliana Tweedie’s A Winter Jaunt to Norway: with Accounts of Nansen, Ibsen, Bjornson, Brandes, and Many Others and Polar Gleams; an Account of a Voyage on the Yacht ‘Blencathra’ by Helen Peel, this article suggests that rather than presenting a polarized gendered perspective of Arctic travel, in their writing Peel and Tweedie negotiate between masculine and feminine-coded associations in order to legitimate and popularize their travels, whilst remaining within the conventions of Victorian femininity.  Of the strategies for ensuring the apparent propriety of their text, the references to clothing are highly significant on several levels. Not only could Peel and Tweedie show their adherence (or not to conventional feminine dress through their descriptions of their clothing, they could also illustrate their relationship to other travellers and the Norwegians they encountered. Thus the ‘petticoat encumbrances’ have a double function in the text. Symbolic of Victorian conventions of femininity and their limitations on women, the adherence to sartorial norms at least indicated to readers and critics of the woman traveller’s compliance with gender conventions. This achieved, the woman travel writer had more scope to embark on her remarkable journey and to write about its potential adventures with enthusiasm as a ‘female adventurer’ and still remain within the acceptable boundaries of late-Victorian femininity.

Nopcsa, Baron Franz. 2014. Traveler, Scholar, Politician, Adventurer – A Transylvanian Baron at the Birth of Albanian Independence (ed. and trans. from German Robert Elsie. Budapest: Central European University Press. 227 pp.

Directory of Open Access Journals (Sweden)

David Mandler

2015-01-01

Full Text Available Nopcsa, Baron Franz. 2014. Traveler, Scholar, Politician, Adventurer – A Transylvanian Baron at the Birth of Albanian Independence (ed. and trans. from German Robert Elsie. Budapest: Central European University Press. 227 pp.  Reviewed by David Mandler, Independent Scholar

Comparison of international guideline programs to evaluate and update the Dutch program for clinical guideline development in physical therapy.

Science.gov (United States)

Van der Wees, Philip J; Hendriks, Erik J M; Custers, Jan W H; Burgers, Jako S; Dekker, Joost; de Bie, Rob A

2007-11-23

Clinical guidelines are considered important instruments to improve quality in health care. Since 1998 the Royal Dutch Society for Physical Therapy (KNGF) produced evidence-based clinical guidelines, based on a standardized program. New developments in the field of guideline research raised the need to evaluate and update the KNGF guideline program. Purpose of this study is to compare different guideline development programs and review the KNGF guideline program for physical therapy in the Netherlands, in order to update the program. Six international guideline development programs were selected, and the 23 criteria of the AGREE Instrument were used to evaluate the guideline programs. Information about the programs was retrieved from published handbooks of the organizations. Also, the Dutch program for guideline development in physical therapy was evaluated using the AGREE criteria. Further comparison the six guideline programs was carried out using the following elements of the guideline development processes: Structure and organization; Preparation and initiation; Development; Validation; Dissemination and implementation; Evaluation and update. Compliance with the AGREE criteria of the guideline programs was high. Four programs addressed 22 AGREE criteria, and two programs addressed 20 AGREE criteria. The previous Dutch program for guideline development in physical therapy lacked in compliance with the AGREE criteria, meeting only 13 criteria. Further comparison showed that all guideline programs perform systematic literature searches to identify the available evidence. Recommendations are formulated and graded, based on evidence and other relevant factors. It is not clear how decisions in the development process are made. In particular, the process of translating evidence into practice recommendations can be improved. As a result of international developments and consensus, the described processes for developing clinical practice guidelines have much in common

Onde está o risco? Os seguros no contexto do turismo de aventura Where is the risk? Insurance in the context of adventure tourism

Directory of Open Access Journals (Sweden)

Mary Jane Spink

2004-08-01

Full Text Available A indústria de seguros vem respondendo à crescente exposição deliberada ao risco no contexto do turismo de aventura. Os seguros constituem apenas uma das possíveis aplicações de tecnologias do risco, mas têm se tornado um dos elementos centrais nos diferentes tipos de contratos estabelecidos pelas operadoras de turismo. Procuramos, neste artigo, responder à pergunta: de quem é a responsabilidade pelos danos, quando o risco é ativamente procurado como forma de lazer? Abordaremos inicialmente a inserção da proposta de estudo no contexto da literatura sobre risco e aspectos gerais da regulação do turismo de aventura no Brasil. A seguir, por meio de estudo de caso de uma operadora de turismo de aventura, analisaremos como é garantida a segurança do usuário no jogo de relações entre mercado de turismo, seguros e Estado. Concluiremos com breves considerações sobre a partilha dos danos e responsabilidades entre operadoras de seguros e de turismo, Estado e usuários, apontando ainda para possíveis mudanças no cenário atualmente configurado.The insurance industry has been quick to respond to the increase in deliberate exposure to risk in the context of adventure tourism. Although insurance is only one aspect of the possible applications of risk technologies, it has become a central element in the variety of contracts established between tourism operators and clients. This article addresses the question: who has responsibility for damages incurred when risk is actively sought in leisure pursuits? Initially we'll discuss risk-adventure in the context of the literature on risk and the regulation of adventure tourism in Brazil. Based on a case study of a tourism office offering leisure activities in nature, it proceeds with an analysis of how client safety is guaranteed in the network of relationships involving tourism market, insurance industry and State regulation. It concludes with brief considerations about the distribution of

A comparison of the effect of short-acting and long-acting cloxacillin-based dry-cow therapy on somatic cell counts after calving in cows also given internal teat sealants.

Science.gov (United States)

Whitfield, L K; Laven, R A

2018-01-01

To compare, in cows treated with an internal teat sealant, the effect of short-acting and long-acting cloxacillin-based dry-cow therapy on somatic cell counts (SCC) after calving. Cows from a spring-calving, pasture-based dairy farm in the Manawatu-Whanganui region of New Zealand were randomly allocated to receive either a short-acting cloxacillin and ampicillin dry-cow therapy and internal teat sealant (n=291) or a long-acting cloxacillin and ampicillin dry-cow therapy and internal teat sealant (n=288) at the end of lactation. Cows were managed on-farm with routine husbandry procedures through the dry period and following calving. A multivariable logistic regression model was used to determine the association between length of action of dry-cow therapy and the proportion of cows with a SCC >150,000 cells/mL at the first herd test after calving. Age of cow, mean SCC for the preceding season and interval from calving to the first post-calving herd test were all associated with the proportion of cows with an individual SCC >150,000 cells/mL at the first herd test (pcow therapy was not associated with decreased odds of cows having a SCC >150,000 cells/mL at the first herd test compared with treatment with long-acting dry-cow therapy (OR=0.724; 95% CI=0.40-1.30). In this herd, which routinely used internal teat sealants, the use of short-acting cloxacillin-based dry-cow therapy did not result in an increased proportion of cows with elevated SSC post-calving. This was a single farm, single year study but indicates that in this herd, changing from a long-acting to a short-acting antimicrobial may have no impact on the prevalence of subclinical mastitis.

MO-A-BRB-01: Review of TG-262 Internal Survey of Practices in EMR for External Beam Therapy

International Nuclear Information System (INIS)

Mechalakos, J.

2015-01-01

The process of converting to an electronic chart for radiation therapy can be daunting. It requires a dedicated committee to first research and choose appropriate software, to review the entire documentation policy and flow of the clinic, to convert this system to electronic form or if necessary, redesign the system to more easily conform to the electronic process. Those making the conversion and those who already use electronic charting would benefit from the shared experience of those who have been through the process in the past. Therefore TG262 was convened to provide guidance on electronic charting for external beam radiation therapy and brachytherapy. This course will present the results of an internal survey of task group members on EMR practices in External Beam Radiation Therapy as well as discuss important issues in EMR development and structure for both EBRT and brachytherapy. Learning Objectives: Be familiarized with common practices and pitfalls in development and maintenance of an electronic chart in Radiation Oncology Be familiarized with important issues related to electronic charting in External Beam Radiation Therapy Be familiarized with important issues related to electronic charting in Brachytherapy

Second International Conference on Near-Field Optical Analysis: Photodynamic Therapy and Photobiology Effects

Science.gov (United States)

Bulgher, Debra L. (Editor); Morrison, Dennis

2002-01-01

The International NASA/DARPA Photobiology Conference held at the Johnson Space Center in Houston/TX demonstrated where low level laser therapy (LLLT), respectively low intensity light activated biostimulation (LILAB) and nanotechnological applications employing photobiomodulation techniques will presumably go in the next ten years. The conference was a continuation of the 1st International Conference on Nearfield Optical Analysis organized by Andrei Sommer (ENSOMA Lab, University of Ulm, Germany) in November 2000 at Castle Reisenburg, Germany, which started with a group of ten scientists from eight different countries. The 1st conference was co-sponsored by the American Chemical Society to evaluate the molecular mechanism of accelerated and normal wound healing processes. The 2nd conference was co-sponsored by DARPA, NASA-JSC and the Medical College of Wisconsin. Despite the short time between events, the 2nd conference hosted 40 international experts form universities, research institutes, agencies and the industry. The materials published here are expected to become milestones forming a novel platform in biomedical photobiology. The multidisciplinary group of researchers focused on LLLT/LILAB-applications under extreme conditions expected to have beneficial effects particularly in space, on submarines, and under severe battlefield conditions. The group also focused on novel technologies with possibilities allowing investigating the interaction of light with biological systems, molecular mechanisms of wound healing, bone regeneration, nerve regeneration, pain modulation, as well as biomineralization and biofilm formulation processes induced by nanobacteria.

Proceedings of the signature series event of the international society for cellular therapy: "Advancements in cellular therapies and regenerative medicine in digestive diseases," London, United Kingdom, May 3, 2017.

Science.gov (United States)

Ciccocioppo, Rachele; Dos Santos, Claudia C; Baumgart, Daniel C; Cangemi, Giuseppina C; Cardinale, Vincenzo; Ciacci, Carolina; De Coppi, Paolo; Haldar, Debashis; Klersy, Catherine; Nostro, M Cristina; Ott, Michael; Piemonti, Lorenzo; Tomei, Alice A; Uygun, Basak; Vetrano, Stefania; Orlando, Giuseppe

2018-03-01

A summary of the First Signature Series Event, "Advancements in Cellular Therapies and Regenerative Medicine for Digestive Diseases," held on May 3, 2017, in London, United Kingdom, is presented. Twelve speakers from three continents covered major topics in the areas of cellular therapy and regenerative medicine applied to liver and gastrointestinal medicine as well as to diabetes mellitus. Highlights from their presentations, together with an overview of the global impact of digestive diseases and a proposal for a shared online collection and data-monitoring platform tool, are included in this proceedings. Although growing evidence demonstrate the feasibility and safety of exploiting cell-based technologies for the treatment of digestive diseases, regulatory and methodological obstacles will need to be overcome before the successful implementation in the clinic of these novel attractive therapeutic strategies. Copyright © 2017 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.

Comparison of international guideline programs to evaluate and update the Dutch program for clinical guideline development in physical therapy

Directory of Open Access Journals (Sweden)

Burgers Jako S

2007-11-01

Full Text Available Abstract Background Clinical guidelines are considered important instruments to improve quality in health care. Since 1998 the Royal Dutch Society for Physical Therapy (KNGF produced evidence-based clinical guidelines, based on a standardized program. New developments in the field of guideline research raised the need to evaluate and update the KNGF guideline program. Purpose of this study is to compare different guideline development programs and review the KNGF guideline program for physical therapy in the Netherlands, in order to update the program. Method Six international guideline development programs were selected, and the 23 criteria of the AGREE Instrument were used to evaluate the guideline programs. Information about the programs was retrieved from published handbooks of the organizations. Also, the Dutch program for guideline development in physical therapy was evaluated using the AGREE criteria. Further comparison the six guideline programs was carried out using the following elements of the guideline development processes: Structure and organization; Preparation and initiation; Development; Validation; Dissemination and implementation; Evaluation and update. Results Compliance with the AGREE criteria of the guideline programs was high. Four programs addressed 22 AGREE criteria, and two programs addressed 20 AGREE criteria. The previous Dutch program for guideline development in physical therapy lacked in compliance with the AGREE criteria, meeting only 13 criteria. Further comparison showed that all guideline programs perform systematic literature searches to identify the available evidence. Recommendations are formulated and graded, based on evidence and other relevant factors. It is not clear how decisions in the development process are made. In particular, the process of translating evidence into practice recommendations can be improved. Conclusion As a result of international developments and consensus, the described processes

Is Endoscopic Therapy Safe for Upper Gastrointestinal Bleeding in Anticoagulated Patients With Supratherapeutic International Normalized Ratios?

Science.gov (United States)

Shim, Choong Nam; Chung, Hyun Soo; Park, Jun Chul; Shin, Sung Kwan; Lee, Sang Kil; Lee, Yong Chan; Kim, Ha Yan; Kim, Dong Wook; Lee, Hyuk

2016-01-01

The management of upper gastrointestinal bleeding (UGIB) in anticoagulated patients with supratherapeutic international normalized ratios (INRs) presents a challenge. The purpose of the study was to evaluate the safety of endoscopic therapy for UGIB in anticoagulated patients with supratherapeutic INR in terms of rebleeding and therapeutic outcomes. One hundred ninety-two anticoagulated patients who underwent endoscopic treatment for UGIB were enrolled in the study. Patients were divided into 2 groups based on the occurrence of rebleeding within 30 days of the initial therapeutic endoscopy: no-rebleeding group (n = 168) and rebleeding group (n = 24). The overall rebleeding rate was 12.5%. Bleeding from gastric cancer and bleeding at the duodenum were significantly related to rebleeding in a univariate analysis. Multivariate analysis determined that presenting symptoms other than melena (hematemesis, hematochezia, or others) (odds ratio, 3.93; 95% confidence interval, 1.44-10.76) and bleeding from gastric cancer (odds ratio, 6.10; 95% confidence interval, 1.27-29.25) were significant factors predictive of rebleeding. Supratherapeutic INR at the time of endoscopic therapy was not significantly associated with rebleeding in either univariate or multivariate analysis. Significant differences in bleeding-related mortality, additional intervention to control bleeding, length of hospital stay, and transfusion requirements were revealed between the rebleeding and no-rebleeding groups. There were no significant differences in therapeutic outcomes between patients with INR within the therapeutic range and those with supratherapeutic INR. Supratherapeutic INR at the time of endoscopic therapy did not change rebleeding and therapeutic outcomes. Thus, we should consider endoscopic therapy for UGIB in anticoagulated patients, irrespective of INR at the time of endoscopic therapy.

Development of a booklet on insulin therapy for children with diabetes mellitus type 1.

Science.gov (United States)

Moura, Denizielle de Jesus Moreira; Moura, Nádya Dos Santos; Menezes, Luciana Catunda Gomes de; Barros, Ariane Alves; Guedes, Maria Vilani Cavalcante

2017-01-01

to describe the process of developing of an educational booklet on insulin therapy for children with diabetes mellitus type 1. methodological approach, in which the following steps were carried out: selecting of the content and type of technology to be developed (for this step, an integrative review, an analysis of the comments of blogs about Diabetes Mellitus type 1 and interviews with the children were performed), creation of images, formatting and layout composition. the work resulted in the production of the final version of the educational booklet, which was titled Aplicando a insulina: a aventura de Beto [Applying insulin: Beto's adventure]. The process of developing of the booklet was based on the active participation of the children and guided by the theoretical framework of Piagetian Constructivism. the resource is a facilitator for the improvement of the knowledge and practices of self care of children with Diabetes Mellitus type 1.

Grado de adaptación en las traducciones de “Alice’s Adventures in Wonderland”

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Ismael Lemus Montaño

2009-01-01

Full Text Available Resumen: La distinción entre la literatura infantil y la juvenil sigue a menudo criterios vagos o muy flexibles. A la hora de traducir obras como Alicia en el país de las maravillas, de Lewis Carroll, los traductores pueden llegar a crear dos o más textos meta diferentes, dependiendo de las características de los lectores de la lengua meta, y ello necesariamente supone una reflexión sobre la difusa frontera entre las dos categorías de literatura.Summary: The distinctions between children’s literature and young-adult literature are often flexible and loosely defined. When translating works such as Lewis Carroll’s Alice’s Adventures in Wonderland, translators must produce two or more different target texts, according to the features of the readers in the target language, and somehow it means a reflection about the fuzzy line between the two literature categories.

CFD Analysis of Square Flow Channel in Thermal Engine Rocket Adventurer for Space Nuclear Application

Energy Technology Data Exchange (ETDEWEB)

Nam, S. H.; Suh, K. Y. [Seoul National University, Seoul (Korea, Republic of); Kang, S. G. [PHILOSOPHIA, Inc., Seoul (Korea, Republic of)

2008-10-15

Solar system exploration relying on chemical rockets suffers from long trip time and high cost. In this regard nuclear propulsion is an attractive option for space exploration. The performance of Nuclear Thermal Rocket (NTR) is more than twice that of the best chemical rocket. Resorting to the pure hydrogen (H{sub 2}) propellant the NTRs can possibly achieve as high as 1,000 s of specific impulse (I{sub sp}) representing the ratio of the thrust over the fuel consumption rate, as compared to only 425 s of H{sub 2}/O{sub 2} rockets. If we reflect on the mission to Mars, NTRs would reduce the round trip time to less than 300 days, instead of over 600 days with chemical rockets. This work presents CFD analysis of one Fuel Element (FE) of Thermal Engine Rocket Adventurer (TERA). In particular, one Square Flow Channel (SFC) is analyzed in Square Lattice Honeycomb (SLHC) fuel to examine the effects of mass flow rate on rocket performance.

CFD Analysis of Square Flow Channel in Thermal Engine Rocket Adventurer for Space Nuclear Application

International Nuclear Information System (INIS)

Nam, S. H.; Suh, K. Y.; Kang, S. G.

2008-01-01

Solar system exploration relying on chemical rockets suffers from long trip time and high cost. In this regard nuclear propulsion is an attractive option for space exploration. The performance of Nuclear Thermal Rocket (NTR) is more than twice that of the best chemical rocket. Resorting to the pure hydrogen (H 2 ) propellant the NTRs can possibly achieve as high as 1,000 s of specific impulse (I sp ) representing the ratio of the thrust over the fuel consumption rate, as compared to only 425 s of H 2 /O 2 rockets. If we reflect on the mission to Mars, NTRs would reduce the round trip time to less than 300 days, instead of over 600 days with chemical rockets. This work presents CFD analysis of one Fuel Element (FE) of Thermal Engine Rocket Adventurer (TERA). In particular, one Square Flow Channel (SFC) is analyzed in Square Lattice Honeycomb (SLHC) fuel to examine the effects of mass flow rate on rocket performance

CERN, an adventure in international scientific cooperation

CERN Document Server

Bannier, J H

1977-01-01

Outlines the history of the Conseil European pour la Recherche Nucleaire (CERN) from its origins in 1951-53 and its establishment on a site on the Swiss-French border near Geneva. Describes the structure of the organisation and discusses the more important policy decisions of the 1960s and 1970s. Concludes by considering future prospects. (0 refs).

XVII International Conference on the Use of Computers in Radiation Therapy (ICCR 2013)

Science.gov (United States)

2014-03-01

Editorial Dear colleagues, From a professional perspective there is nothing quite as enjoyable as attending a good conference with colleagues that share not only interest for the same topic but also a similar vision for their field of work. Proceedings cannot replace the direct contact and lively conversations between participants who are at the same time at the same place sharing ideas and discussion. However, proceedings complement the actual conference by 1. giving the ideas, research findings and debates which characterise the conference lasting presence 2. giving participants an opportunity to refresh their memory about issues they would like to follow up on and 3. providing an opportunity for others who were not able to attend the meeting to share in the thoughts and issues discussed at the conference. For the proceedings of the International Conferences on the Use of Computers in Radiation Therapy (ICCR) all this has been important in the past as the high citation rates for ICCR proceedings show. We hope that also the present proceedings will appeal to participants and others who are interested in cancer and ways to treat patients affected by it. It is exciting to note that what sounded like a small niche field (''Computers in Radiation Therapy'') has become a very broad forum to discuss all aspects of cancer diagnosis and therapy. Of particular interest for the 17th ICCR have been data and how to collect, organise and use it effectively. This is relevant for most areas in medicine and we believe that radiation therapy with its focus on evidence based practice and measurable and standardised activities has an important and possibly leading role to play. The 100 manuscripts combined in the present proceedings can hopefully contribute to this. The proceedings are organised into five different streams which reflect the foci of the conference: • Dose Calculation • Imaging for treatment planning and Motion Management • Treatment planning and optimisation �

Alignment of Outcome Instruments Used in Hand Therapy With the Occupational Therapy Practice Framework: Domain and Process and the International Classification of Functioning, Disability and Health: A Scoping Review.

Science.gov (United States)

Lesher, Danielle Ann-Marie; Mulcahey, M J; Hershey, Peter; Stanton, Donna Breger; Tiedgen, Andrea C

We sought to identify outcome instruments used in rehabilitation of the hand and upper extremity; to determine their alignment with the constructs of the International Classification of Functioning, Disability and Health (ICF) and the Occupational Therapy Practice Framework: Domain and Process; and to report gaps in the constructs measured by outcome instruments as a basis for future research. We searched CINAHL, MEDLINE, OTseeker, and the Cochrane Central Register of Controlled Trials using scoping review methodology and evaluated outcome instruments for concordance with the ICF and the Framework. We identified 18 outcome instruments for analysis. The findings pertain to occupational therapists' focus on body functions, body structures, client factors, and activities of daily living; a gap in practice patterns in use of instruments; and overestimation of the degree to which instruments used are occupationally based. Occupational therapy practitioners should use outcome instruments that embody conceptual frameworks for classifying function and activity. Copyright © 2017 by the American Occupational Therapy Association, Inc.

Modern Radiation Therapy for Nodal Non-Hodgkin Lymphoma—Target Definition and Dose Guidelines From the International Lymphoma Radiation Oncology Group

DEFF Research Database (Denmark)

Illidge, Tim; Specht, Lena; Yahalom, Joachim

2014-01-01

Radiation therapy (RT) is the most effective single modality for local control of non-Hodgkin lymphoma (NHL) and is an important component of therapy for many patients. Many of the historic concepts of dose and volume have recently been challenged by the advent of modern imaging and RT planning...... tools. The International Lymphoma Radiation Oncology Group (ILROG) has developed these guidelines after multinational meetings and analysis of available evidence. The guidelines represent an agreed consensus view of the ILROG steering committee on the use of RT in NHL in the modern era. The roles...... of reduced volume and reduced doses are addressed, integrating modern imaging with 3-dimensional planning and advanced techniques of RT delivery. In the modern era, in which combined-modality treatment with systemic therapy is appropriate, the previously applied extended-field and involved-field RT...

A Prospective Cohort Study of Gated Stereotactic Liver Radiation Therapy Using Continuous Internal Electromagnetic Motion Monitoring

DEFF Research Database (Denmark)

Worm, Esben S; Høyer, Morten; Hansen, Rune

2018-01-01

PURPOSE: Intrafraction motion can compromise the treatment accuracy in liver stereotactic body radiation therapy (SBRT). Respiratory gating can improve treatment delivery; however, gating based on external motion surrogates is inaccurate. The present study reports the use of Calypso-based internal...... electromagnetic motion monitoring for gated liver SBRT. METHODS AND MATERIALS: Fifteen patients were included in a study of 3-fraction respiratory gated liver SBRT guided by 3 implanted electromagnetic transponders. The planning target volume was created by a 5-mm axial and 7-mm (n = 12) or 10-mm (n = 3...

Design of an international multicentre RCT on group schema therapy for borderline personality disorder.

Science.gov (United States)

Wetzelaer, Pim; Farrell, Joan; Evers, Silvia M A A; Jacob, Gitta A; Lee, Christopher W; Brand, Odette; van Breukelen, Gerard; Fassbinder, Eva; Fretwell, Heather; Harper, R Patrick; Lavender, Anna; Lockwood, George; Malogiannis, Ioannis A; Schweiger, Ulrich; Startup, Helen; Stevenson, Teresa; Zarbock, Gerhard; Arntz, Arnoud

2014-11-18

Borderline personality disorder (BPD) is a severe and highly prevalent mental disorder. Schema therapy (ST) has been found effective in the treatment of BPD and is commonly delivered through an individual format. A group format (group schema therapy, GST) has also been developed. GST has been found to speed up and amplify the treatment effects found for individual ST. Delivery in a group format may lead to improved cost-effectiveness. An important question is how GST compares to treatment as usual (TAU) and what format for delivery of schema therapy (format A; intensive group therapy only, or format B; a combination of group and individual therapy) produces the best outcomes. An international, multicentre randomized controlled trial (RCT) will be conducted with a minimum of fourteen participating centres. Each centre will recruit multiple cohorts of at least sixteen patients. GST formats as well as the orders in which they are delivered to successive cohorts will be balanced. Within countries that contribute an uneven number of sites, the orders of GST formats will be balanced within a difference of one. The RCT is designed to include a minimum of 448 patients with BPD. The primary clinical outcome measure will be BPD severity. Secondary clinical outcome measures will include measures of BPD and general psychiatric symptoms, schemas and schema modes, social functioning and quality of life. Furthermore, an economic evaluation that consists of cost-effectiveness and cost-utility analyses will be performed using a societal perspective. Lastly, additional investigations will be carried out that include an assessment of the integrity of GST, a qualitative study on patients' and therapists' experiences with GST, and studies on variables that might influence the effectiveness of GST. This trial will compare GST to TAU for patients with BPD as well as two different formats for the delivery of GST. By combining an evaluation of clinical effectiveness, an economic evaluation

Can cannabis use be prevented by targeting personality risk in schools? Twenty?four?month outcome of the adventure trial on cannabis use: a cluster?randomized controlled trial

OpenAIRE

Mahu, Ioan T.; Doucet, Christine; O'Leary?Barrett, Maeve; Conrod, Patricia J.

2015-01-01

Aims To examine the effectiveness of a personality?targeted intervention program (Adventure trial) delivered by trained teachers to high?risk (HR) high?school students on reducing marijuana use and frequency of use. Design A cluster?randomized controlled trial. Setting Secondary schools in London, UK. Participants Twenty?one secondary schools were randomized to intervention (n?=?12) or control (n?=?9) conditions, encompassing a total of 1038 HR students in the ninth grade [mean (standard devi...

Practice Patterns Analysis of Ocular Proton Therapy Centers: The International OPTIC Survey

International Nuclear Information System (INIS)

Hrbacek, Jan; Mishra, Kavita K.; Kacperek, Andrzej; Dendale, Remi; Nauraye, Catherine; Auger, Michel; Herault, Joel; Daftari, Inder K.; Trofimov, Alexei V.; Shih, Helen A.; Chen, Yen-Lin E.; Denker, Andrea; Heufelder, Jens; Horwacik, Tomasz; Swakoń, Jan; Hoehr, Cornelia; Duzenli, Cheryl; Pica, Alessia; Goudjil, Farid; Mazal, Alejandro

2016-01-01

Purpose: To assess the planning, treatment, and follow-up strategies worldwide in dedicated proton therapy ocular programs. Methods and Materials: Ten centers from 7 countries completed a questionnaire survey with 109 queries on the eye treatment planning system (TPS), hardware/software equipment, image acquisition/registration, patient positioning, eye surveillance, beam delivery, quality assurance (QA), clinical management, and workflow. Results: Worldwide, 28,891 eye patients were treated with protons at the 10 centers as of the end of 2014. Most centers treated a vast number of ocular patients (1729 to 6369). Three centers treated fewer than 200 ocular patients. Most commonly, the centers treated uveal melanoma (UM) and other primary ocular malignancies, benign ocular tumors, conjunctival lesions, choroidal metastases, and retinoblastomas. The UM dose fractionation was generally within a standard range, whereas dosing for other ocular conditions was not standardized. The majority (80%) of centers used in common a specific ocular TPS. Variability existed in imaging registration, with magnetic resonance imaging (MRI) rarely being used in routine planning (20%). Increased patient to full-time equivalent ratios were observed by higher accruing centers (P=.0161). Generally, ophthalmologists followed up the post–radiation therapy patients, though in 40% of centers radiation oncologists also followed up the patients. Seven centers had a prospective outcomes database. All centers used a cyclotron to accelerate protons with dedicated horizontal beam lines only. QA checks (range, modulation) varied substantially across centers. Conclusions: The first worldwide multi-institutional ophthalmic proton therapy survey of the clinical and technical approach shows areas of substantial overlap and areas of progress needed to achieve sustainable and systematic management. Future international efforts include research and development for imaging and planning software upgrades

Practice Patterns Analysis of Ocular Proton Therapy Centers: The International OPTIC Survey

Energy Technology Data Exchange (ETDEWEB)

Hrbacek, Jan, E-mail: Jan.hrbacek@psi.ch [Center for Proton Therapy, Paul Scherrer Institute, Villigen (Switzerland); Mishra, Kavita K. [Ocular Tumor Proton Therapy Program, University of California San Francisco, San Francisco, California (United States); Kacperek, Andrzej [National Proton Therapy Centre, Clatterbridge Cancer Centre, Bebington (United Kingdom); Dendale, Remi; Nauraye, Catherine; Auger, Michel [Centre de Protonthérapie d' Orsay, Institut Curie, Orsay (France); Herault, Joel [Centre Lacassagne, Nice (France); Daftari, Inder K. [Ocular Tumor Proton Therapy Program, University of California San Francisco, San Francisco, California (United States); Trofimov, Alexei V.; Shih, Helen A.; Chen, Yen-Lin E. [F. H. Burr Proton Therapy Center, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (United States); Denker, Andrea [Protons for Therapy, Helmholtz-Zentrum Berlin, Berlin (Germany); Heufelder, Jens [BerlinProtonen am HZB, Charité – Universitätsmedizin Berlin, Berlin (Germany); Horwacik, Tomasz; Swakoń, Jan [Institute of Nuclear Physic, Polish Academy of Sciences, Krakow (Poland); Hoehr, Cornelia; Duzenli, Cheryl [BC Cancer Agency – TRIUMF, Vancouver (Canada); Pica, Alessia [Center for Proton Therapy, Paul Scherrer Institute, Villigen (Switzerland); Goudjil, Farid; Mazal, Alejandro [Centre de Protonthérapie d' Orsay, Institut Curie, Orsay (France); and others

2016-05-01

Purpose: To assess the planning, treatment, and follow-up strategies worldwide in dedicated proton therapy ocular programs. Methods and Materials: Ten centers from 7 countries completed a questionnaire survey with 109 queries on the eye treatment planning system (TPS), hardware/software equipment, image acquisition/registration, patient positioning, eye surveillance, beam delivery, quality assurance (QA), clinical management, and workflow. Results: Worldwide, 28,891 eye patients were treated with protons at the 10 centers as of the end of 2014. Most centers treated a vast number of ocular patients (1729 to 6369). Three centers treated fewer than 200 ocular patients. Most commonly, the centers treated uveal melanoma (UM) and other primary ocular malignancies, benign ocular tumors, conjunctival lesions, choroidal metastases, and retinoblastomas. The UM dose fractionation was generally within a standard range, whereas dosing for other ocular conditions was not standardized. The majority (80%) of centers used in common a specific ocular TPS. Variability existed in imaging registration, with magnetic resonance imaging (MRI) rarely being used in routine planning (20%). Increased patient to full-time equivalent ratios were observed by higher accruing centers (P=.0161). Generally, ophthalmologists followed up the post–radiation therapy patients, though in 40% of centers radiation oncologists also followed up the patients. Seven centers had a prospective outcomes database. All centers used a cyclotron to accelerate protons with dedicated horizontal beam lines only. QA checks (range, modulation) varied substantially across centers. Conclusions: The first worldwide multi-institutional ophthalmic proton therapy survey of the clinical and technical approach shows areas of substantial overlap and areas of progress needed to achieve sustainable and systematic management. Future international efforts include research and development for imaging and planning software upgrades

A conceptual framework for international service-learning course planning: promoting a foundation for ethical practice in the physical therapy and occupational therapy professions.

Science.gov (United States)

Lattanzi, Jill Black; Pechak, Celia

2011-01-01

As physical therapy (PT) and occupational therapy (OT) educational programs endeavor to foster core values of social responsibility, justice, and altruism in an increasingly global community, the incorporation of local and international service-learning (ISL) into the curriculum is growing. Much of the research has focused on the measurement of student learning, with little written about the impact on the host community. Proponents of global health initiatives are calling for consideration of all stakeholders to ensure ethical practice. This paper explores the current literature related to PT and OT ISL and builds a conceptual framework for ISL course planning. The essential phases in the framework include: 1) pre-experience planning/preparation stage, 2) field immersion experience stage, and 3) postexperience stage. The essential elements are: 1) cultural competency training, 2) communication and coordination with community, 3) comprehensive assessment, and 4) strategic planning. The authors suggest this framework as a practical tool to structure ISL courses with an explicit emphasis on ethical concerns. Additionally, they seek to foster more dialogue and action related to the promotion of ethical practices in ISL in PT and OT education programs.

What are the minimum requirements for ketogenic diet services in resource-limited regions? Recommendations from the International League Against Epilepsy Task Force for Dietary Therapy.

Science.gov (United States)

Kossoff, Eric H; Al-Macki, Nabil; Cervenka, Mackenzie C; Kim, Heung D; Liao, Jianxiang; Megaw, Katherine; Nathan, Janak K; Raimann, Ximena; Rivera, Rocio; Wiemer-Kruel, Adelheid; Williams, Emma; Zupec-Kania, Beth A

2015-09-01

Despite the increasing use of dietary therapies for children and adults with refractory epilepsy, the availability of these treatments in developing countries with limited resources remains suboptimal. One possible contributory factor may be the costs. There is often reported a significant perceived need for a large ketogenic diet team, supplements, laboratory studies, and follow-up visits to provide this treatment. The 2009 Epilepsia Consensus Statement described ideal requirements for a ketogenic diet center, but in some situations this is not feasible. As a result, the International League Against Epilepsy (ILAE) Task Force on Dietary Therapy was asked to convene and provide practical, cost-effective recommendations for new ketogenic diet centers in resource-limited regions of the world. Wiley Periodicals, Inc. © 2015 International League Against Epilepsy.

Fifty-four Years of Adventures in Infrared Astronomy

Science.gov (United States)

Becklin, Eric Eric

2018-01-01

My adventures in infrared astronomy started when I was a grad student in 1965 with the discovery of an infrared-bright object (now known as the Becklin-Neugebauer Object) in the Orion Nebula. In 1966, I made the first measurements of the infrared radiation from the center of the Milky Way Galaxy. I was fortunate enough to be able to take advantage of the 2.2 micron sky survey carried out by Neugebauer and Leighton (1969), which produced many remarkable discoveries, the most spectacular being the heavily dust-embedded carbon star IRC+10216, thebrightest object in the sky at 5 microns outside the solar system. In the 1970’s there was a growth in Infrared astronomy with the availability of many new facilities such as the Kuiper Airborne Observatory, (KAO) which I used extensively with Mike Werner and Ian Gatley for many unique observations. In 1977, I moved to Hawaii to work on the NASA IRTF 3- meter telescope. Many discoveries were made, including the first direct measurements of the rings of Jupiter at 2.2 microns (with Gareth Wynn-Williams) and the discovery of the first L dwarf star around a white dwarf (with Ben Zuckerman). In the 1980’s the introduction of large format arrays changed the way we did infrared astronomy. With Ian McLean, I moved to UCLA in 1990 to start the IR lab and get involved in Keck development and science. In 1995, Andrea, Ghez, Mark Morris and I started looking for evidence of a possible massive Black Hole in the Galactic Center. Spectacular observations using the Keck10 meter telescopes with large format near-infrared arrays and adaptive optics led to the confirmation of the presence of such a black hole and an estimate of its mass (4xE6 M (Sun)). In 1996, I began working on the Stratospheric Observatory For Infrared Astronomy (SOFIA) and I will finish my talk by discussing SOFIA observations of the ring of dust and gas orbiting the massive black hole in the center

Engineering thermal engine rocket adventurer for space nuclear application

International Nuclear Information System (INIS)

Nam, Seung H.; Suh, Kune Y.; Kang, Seong G.

2008-01-01

The conceptual design for the first-of-a-kind engineering of Thermal Engine Rocket Adventure (TERA) is described. TERA comprising the Battery Omnibus Reactor Integral System (BORIS) as the heat resource and the Space Propulsion Reactor Integral System (SPRIS) as the propulsion system, is one of the advanced Nuclear Thermal Rocket (NTR) engine utilizing hydrogen (H 2 ) propellant being developed at present time. BORIS in this application is an open cycle high temperature gas cooled reactor that has eighteen fuel elements for propulsion and one fuel element for electricity generation and propellant pumping. Each fuel element for propulsion has its own small nozzle. The nineteen fuel elements are arranged into hexagonal prism shape in the core and surrounded by outer Be reflector. The TERA maximum power is 1,000 MW th , specific impulse 1,000 s, thrust 250,000 N, and the total mass is 550 kg including the reactor, turbo pump and auxiliaries. Each fuel element comprises the fuel assembly, moderators, pressure tube and small nozzle. The TERA fuel assembly is fabricated of 93% enriched 1.5 mm (U, Zr, Nb)C wafers in 25.3% voided Square Lattice Honeycomb (SLHC). The H 2 propellant passes through these flow channels. This study is concerned with thermohydrodynamic analysis of the fuel element for propulsion with hypothetical axial power distribution because nuclear analysis of TERA has not been performed yet. As a result, when the power distribution of INSPI's M-SLHC is applied to the fuel assembly, the local heat concentration of fuel is more serious and the pressure of the initial inlet H 2 is higher than those of constant average power distribution applied. This means the fuel assembly geometry of 1.5 mm fuel wafers and 25.3% voided SLHC needs to be changed in order to reduce thermal and mechanical shocks. (author)

Art Therapy: A Bibliography.

Science.gov (United States)

Gantt, Linda, Comp.; Schmal, Marilyn Strauss, Comp.

The bibliography on art therapy presents 1175 citations (1940-1973) drawn from searches of the medical indexes, computer systems of the National Library of Medicine and the National Institute of Mental Health, other bibliographies, Centre International de Documentation Concernant les Expressions Plastiques, and the American Journal of Art Therapy.…

Thematic review of family therapy journals in 2013

OpenAIRE

Carr, Alan

2014-01-01

In this article the contents of the principal English-language family therapy journals and key family therapy articles published in other journals in 2013 are reviewed under these headings: models of family therapy, developments in family therapy practice, couple therapy, training, diversity, international developments, research and DSM-5.

FORMAS DE TRATAMENTO EM TRADUÇÕES DE “THE ADVENTURES OF TOM SAWYER”: RELAÇÕES SOCIAIS E AFETIVAS

Directory of Open Access Journals (Sweden)

Giselle Olivia Mantovani Dal Corno

2015-02-01

Full Text Available Mark Twain is a renowned realist author, known by his colloquial style and local colorism. In the novel “The adventures of Tom Sawyer”, he manages to depict oral regional language in the lines of his characters. Address forms used by characters contribute to the representation of social relations in the book. From the analysis of a few dialogs in the original text in English and their translations into Portuguese, this paper will discuss not only oral language indexes but also the ways how the choice of lexical items for addressing reveal different degrees of affectivity and social hierarchy. Some cases of loss in translation are registered as well as one case of domestication, in the terms of Venutti (1998.

Videojuegos como herramienta en Educación Primaria: caso de estudio con eAdventure

Directory of Open Access Journals (Sweden)

Solano Nogales, Luis

2016-12-01

Full Text Available Los videojuegos son herramientas interactivas y sociales de aprendizaje de la Web 2.0, con las que los usuarios pueden jugar, participar, comunicarse y aprender, creando y sacando partido de los contenidos. No obstante el profesorado necesita formación para exprimir de forma eficaz estas herramientas. Con el ánimo de comprobar la eficacia del videojuego como herramienta de enseñanza en el aula, en este artículo se presenta un estudio de caso de la adopción de los videojuegos en Educación Primaria, donde la herramienta eAdventure se ha utilizado para impartir una Unidad Didáctica de la asignatura Ciencias de la Naturaleza a alumnos de siete años. La conclusión a la que se ha llegado tras su realización es que los videojuegos pueden ser utilizados como herramientas educativas y las principales fortalezas de su uso en clase son: (i la reducción en la temporalización a la hora de impartir un contenido y (ii el incremento en la atención de los alumnos.

[Efficacy of the program "Testas's (mis)adventures" to promote the deep approach to learning].

Science.gov (United States)

Rosário, Pedro; González-Pienda, Julio Antonio; Cerezo, Rebeca; Pinto, Ricardo; Ferreira, Pedro; Abilio, Lourenço; Paiva, Olimpia

2010-11-01

This paper provides information about the efficacy of a tutorial training program intended to enhance elementary fifth graders' study processes and foster their deep approaches to learning. The program "Testas's (mis)adventures" consists of a set of books in which Testas, a typical student, reveals and reflects upon his life experiences during school years. These life stories are nothing but an opportunity to present and train a wide range of learning strategies and self-regulatory processes, designed to insure students' deeper preparation for present and future learning challenges. The program has been developed along a school year, in a one hour weekly tutorial sessions. The training program had a semi-experimental design, included an experimental group (n=50) and a control one (n=50), and used pre- and posttest measures (learning strategies' declarative knowledge, learning approaches and academic achievement). Data suggest that the students enrolled in the training program, comparing with students in the control group, showed a significant improvement in their declarative knowledge of learning strategies and in their deep approach to learning, consequently lowering their use of a surface approach. In spite of this, in what concerns to academic achievement, no statistically significant differences have been found.

A qualitative study of intimate partner violence universal screening by family therapy interns: implications for practice, research, training, and supervision.

Science.gov (United States)

Todahl, Jeffrey L; Linville, Deanna; Chou, Liang-Ying; Maher-Cosenza, Patricia

2008-01-01

Although a few family therapy researchers and clinicians have urged universal screening for intimate partner violence (IPV), how screening is implemented-and, in particular, client and therapist response to screening-is vaguely defined and largely untested. This qualitative study examined the dilemmas experienced by couples and family therapy interns when implementing universal screening for IPV in an outpatient clinic setting. Twenty-two graduate students in a COAMFTE-accredited program were interviewed using qualitative research methods grounded in phenomenology. Three domains, 7 main themes, and 26 subthemes were identified. The three domains that emerged in this study include (a) therapist practice of universal screening, (b) client response to universal screening, and (c) therapist response to universal screening. Implications for practice, research, training, and supervision are discussed.

Immunosupportive therapies in aging

Science.gov (United States)

Fülöp, Tamas; Larbi, Anis; Hirokawa, Katsuiku; Mocchegiani, Eugenio; Lesourd, Bruno; Castle, Stephen; Wikby, Anders; Franceschi, Claudio; Pawelec, Graham

2007-01-01

The primary role of the immune system is to protect the organism against pathogens, but age-associated alterations to immunity increase the susceptibility of the elderly to infectious disease. The exact nature of these changes is still controversial, but the use of screening procedures, such as the SENIEUR protocol to exclude underlying illness, helped to better characterize the changes actually related to physiological aging rather than pathology. It is generally agreed that the most marked changes occur in the cellular immune response reflecting profound alterations in T cells. Much of this is due to thymic involution as well as changes in the proportions of T cell subpopulations resulting from antigen exposure, and altered T cell activation pathways. However, a body of data indicates that innate immune responses, including the critical bridge between innate and adaptive immunity, and antigen presenting capacity are not completely resistant to senescence processes. The consequences of all these alterations are an increased incidence of infections, as well as possibly cancers, autoimmune disorders, and chronic inflammatory diseases. The leading question is what, if anything, can we do to prevent these deleterious changes without dangerously dysregulating the precarious balance of productive immunity versus immunopathology? There are many potential new therapeutic means now available to modulate immunosenescence and many others are expected to be available shortly. One main problem in applying these experimental therapies is ethical: there is a common feeling that as ageing is not a disease; the elderly are not sick and therefore do not require adventurous therapies with unpredictable side-effects in mostly frail individuals. Animal models are not helpful in this context. In this chapter we will first briefly review what we think we know about human immunosenescence and its consequences for the health status of elderly individuals. We will then discuss possible

Internal Dosimetry in therapy with 90Y

International Nuclear Information System (INIS)

Torres, Leonel; Vergara, Alex; García, Leonardo

2016-01-01

Introduction: 90 Y has shown satisfactory results in the therapy of multiple oncological diseases. This radionuclide has been widely used in therapy of diseases such as NHL (Zevalin), TNE ( 90 Y-DOTATOC), liver cancer, etc. Its safe and effective use presupposes the availability of accurate dosimetry methods and reproducible.El objective of this work is to standardize and optimize images use procedures that allow for dosimetric estimates braking during therapy of malignant diseases 90 Y. Materials and Methods: To quantify the activity in absolute units from scans correction methods that consider the peculiarities of the bremsstrahlung of 90 Y were proposed. acquisition parameters such as the selection of the collimator and the definition of energy windows as well as methods of scatter correction, attenuation, interactions of radiation with the collimator (septal penetration and degradation of information with distance) were considered and sensitivity or calibration factor was estimated. They were evaluated and calibrated parameters for dosimetry at the level of organ and estimates of distributions 3D dose, using experimental measurements with SPECT Mediso Nucline ™ Spirit DH-V system and simulations were performed using the Monte Carlo method, using the SIMIND v5 software .0. Results: The optimum position-energy window width and collimator to be used is determined from the relationship between total photons and primary photons (T / P), calculated with SIMIND. The results were favorable to employ HEGP collimator and energy window between 90-170kev. the sensitivity of the system for the selected collimator (HEGP for 90 Y) was estimated. He was evaluated and determined the MTF order to correct dispersive plane images, the source-detector and interactions of radiation with the collimator distance, using filtering methods (Wiener filter), including empirical estimates of the SNR component. Similarly the procedure for the use of transmission maps obtained from

Gene therapy of thyroid carcinoma

International Nuclear Information System (INIS)

Zheng Wei; Tan Jian

2007-01-01

Normally, differentiated thyroid carcinoma(DTC) is a disease of good prognosis, but about 30% of the tumors are dedifferentiate, which are inaccessible to standard therapeutic procedures such as 'operation, 131 I therapy and thyroid hormone'. Both internal and abroad experts are researching a new therapy of dedifferentiated thyroid carcinoma--gene therapy. Many of them utilize methods of it, but follow different strategies: (1) transduction of the thyroid sodium/iodide transporter gene to make tissues that do not accumulate iodide treatable by 131 I therapy; (2) strengthening of the anti-tumor immune response; (3) suicide gene therapy; (4) depression the generation of tumor cells; (5) gene therapy of anti- vascularization. (authors)

International Journal of Arts and Humanities (IJAH) Bahir Dar- Ethiopia

African Journals Online (AJOL)

Nneka Umera-Okeke

these sexual rights of women which often times, leads them into prostitution and ... the inability of the family to protect its adventurous members, ... sexual intercourse with her, without understanding the meaning of the game. ... his friends. ... nightclub after showing her the video coverage on how different men took turns to ...

Yttrium-90 Selective Internal Radiation Therapy with Glass Microspheres for Hepatocellular Carcinoma: Current and Updated Literature Review

Energy Technology Data Exchange (ETDEWEB)

Lee, Edward Wolfgang; Alanis, Lourdes [Division of Interventional Radiology, Department of Radiology, UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 (United States); Cho, Sung-Ki [Division of Interventional Radiology, Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351 (Korea, Republic of); Saab, Sammy [Division of Hepatology, Department of Medicine, Pfleger Liver Institute, University of California at Los Angeles, Los Angeles, CA 90024 (United States)

2016-11-01

Hepatocellular carcinoma is the most common primary liver cancer and it represents the majority of cancer-related deaths in the world. More than 70% of patients present at an advanced stage, beyond potentially curative options. Ytrrium-90 selective internal radiation therapy (Y90-SIRT) with glass microspheres is rapidly gaining acceptance as a potential therapy for intermediate and advanced stage primary hepatocellular carcinoma and liver metastases. The technique involves delivery of Y90 infused glass microspheres via the hepatic arterial blood flow to the appropriate tumor. The liver tumor receives a highly concentrated radiation dose while sparing the healthy liver parenchyma due to its preferential blood supply from portal venous blood. There are two commercially available devices: TheraSphere® and SIR-Spheres®. Although, Y90-SIRT with glass microspheres improves median survival in patients with intermediate and advanced hepatocellular carcinoma and has the potential to downstage hepatocellular carcinoma so that the selected candidates meet the transplantable criteria, it has not gained widespread acceptance due to the lack of large randomized controlled trials. Currently, there are various clinical trials investigating the use of Y90-SIRT with glass microspheres for treatment of hepatocellular carcinoma and the outcomes of these trials may result in the incorporation of Y90-SIRT with glass microspheres into the treatment guidelines as a standard therapy option for patients with intermediate and advanced stage hepatocellular carcinoma.

Yttrium-90 selective internal radiation therapy with glass microspheres for hepatocellular carcinoma: Current and updated literature review

International Nuclear Information System (INIS)

Lee, Edward Wolfgang; Alanic, Lourdes; Cho, Sung Ki; Saab, Sammy

2016-01-01

Hepatocellular carcinoma is the most common primary liver cancer and it represents the majority of cancer-related deaths in the world. More than 70% of patients present at an advanced stage, beyond potentially curative options. Ytrrium-90 selective internal radiation therapy (Y90-SIRT) with glass microspheres is rapidly gaining acceptance as a potential therapy for intermediate and advanced stage primary hepatocellular carcinoma and liver metastases. The technique involves delivery of Y90 infused glass microspheres via the hepatic arterial blood flow to the appropriate tumor. The liver tumor receives a highly concentrated radiation dose while sparing the healthy liver parenchyma due to its preferential blood supply from portal venous blood. There are two commercially available devices: TheraSphere® and SIR-Spheres®. Although, Y90-SIRT with glass microspheres improves median survival in patients with intermediate and advanced hepatocellular carcinoma and has the potential to downstage hepatocellular carcinoma so that the selected candidates meet the transplantable criteria, it has not gained widespread acceptance due to the lack of large randomized controlled trials. Currently, there are various clinical trials investigating the use of Y90-SIRT with glass microspheres for treatment of hepatocellular carcinoma and the outcomes of these trials may result in the incorporation of Y90-SIRT with glass microspheres into the treatment guidelines as a standard therapy option for patients with intermediate and advanced stage hepatocellular carcinoma

Yttrium-90 Selective Internal Radiation Therapy with Glass Microspheres for Hepatocellular Carcinoma: Current and Updated Literature Review

International Nuclear Information System (INIS)

Lee, Edward Wolfgang; Alanis, Lourdes; Cho, Sung-Ki; Saab, Sammy

2016-01-01

Hepatocellular carcinoma is the most common primary liver cancer and it represents the majority of cancer-related deaths in the world. More than 70% of patients present at an advanced stage, beyond potentially curative options. Ytrrium-90 selective internal radiation therapy (Y90-SIRT) with glass microspheres is rapidly gaining acceptance as a potential therapy for intermediate and advanced stage primary hepatocellular carcinoma and liver metastases. The technique involves delivery of Y90 infused glass microspheres via the hepatic arterial blood flow to the appropriate tumor. The liver tumor receives a highly concentrated radiation dose while sparing the healthy liver parenchyma due to its preferential blood supply from portal venous blood. There are two commercially available devices: TheraSphere® and SIR-Spheres®. Although, Y90-SIRT with glass microspheres improves median survival in patients with intermediate and advanced hepatocellular carcinoma and has the potential to downstage hepatocellular carcinoma so that the selected candidates meet the transplantable criteria, it has not gained widespread acceptance due to the lack of large randomized controlled trials. Currently, there are various clinical trials investigating the use of Y90-SIRT with glass microspheres for treatment of hepatocellular carcinoma and the outcomes of these trials may result in the incorporation of Y90-SIRT with glass microspheres into the treatment guidelines as a standard therapy option for patients with intermediate and advanced stage hepatocellular carcinoma

Yttrium-90 selective internal radiation therapy with glass microspheres for hepatocellular carcinoma: Current and updated literature review

Energy Technology Data Exchange (ETDEWEB)

Lee, Edward Wolfgang; Alanic, Lourdes [Div. of Interventional Radiology, Dept. of Radiology, UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles (United States); Cho, Sung Ki [Div. of Interventional Radiology, Dept. of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Saab, Sammy [Div. of Hepatology, Dept. of Medicine, Pfleger Liver Institute, University of California at Los Angeles, Los Angeles (United States)

2016-07-15

Hepatocellular carcinoma is the most common primary liver cancer and it represents the majority of cancer-related deaths in the world. More than 70% of patients present at an advanced stage, beyond potentially curative options. Ytrrium-90 selective internal radiation therapy (Y90-SIRT) with glass microspheres is rapidly gaining acceptance as a potential therapy for intermediate and advanced stage primary hepatocellular carcinoma and liver metastases. The technique involves delivery of Y90 infused glass microspheres via the hepatic arterial blood flow to the appropriate tumor. The liver tumor receives a highly concentrated radiation dose while sparing the healthy liver parenchyma due to its preferential blood supply from portal venous blood. There are two commercially available devices: TheraSphere® and SIR-Spheres®. Although, Y90-SIRT with glass microspheres improves median survival in patients with intermediate and advanced hepatocellular carcinoma and has the potential to downstage hepatocellular carcinoma so that the selected candidates meet the transplantable criteria, it has not gained widespread acceptance due to the lack of large randomized controlled trials. Currently, there are various clinical trials investigating the use of Y90-SIRT with glass microspheres for treatment of hepatocellular carcinoma and the outcomes of these trials may result in the incorporation of Y90-SIRT with glass microspheres into the treatment guidelines as a standard therapy option for patients with intermediate and advanced stage hepatocellular carcinoma.

Yttrium-90 Selective Internal Radiation Therapy with Glass Microspheres for Hepatocellular Carcinoma: Current and Updated Literature Review.

Science.gov (United States)

Lee, Edward Wolfgang; Alanis, Lourdes; Cho, Sung-Ki; Saab, Sammy

2016-01-01

Hepatocellular carcinoma is the most common primary liver cancer and it represents the majority of cancer-related deaths in the world. More than 70% of patients present at an advanced stage, beyond potentially curative options. Ytrrium-90 selective internal radiation therapy (Y90-SIRT) with glass microspheres is rapidly gaining acceptance as a potential therapy for intermediate and advanced stage primary hepatocellular carcinoma and liver metastases. The technique involves delivery of Y90 infused glass microspheres via the hepatic arterial blood flow to the appropriate tumor. The liver tumor receives a highly concentrated radiation dose while sparing the healthy liver parenchyma due to its preferential blood supply from portal venous blood. There are two commercially available devices: TheraSphere® and SIR-Spheres®. Although, Y90-SIRT with glass microspheres improves median survival in patients with intermediate and advanced hepatocellular carcinoma and has the potential to downstage hepatocellular carcinoma so that the selected candidates meet the transplantable criteria, it has not gained widespread acceptance due to the lack of large randomized controlled trials. Currently, there are various clinical trials investigating the use of Y90-SIRT with glass microspheres for treatment of hepatocellular carcinoma and the outcomes of these trials may result in the incorporation of Y90-SIRT with glass microspheres into the treatment guidelines as a standard therapy option for patients with intermediate and advanced stage hepatocellular carcinoma.

The Challenge of Translating Children’s Literature: Alice’s Adventures in Wonderland Translated by Vladimir Nabokov

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Natalija Vid

2008-06-01

Full Text Available In the article the author focuses on Vladimir Nabokov’s translation of Lewis Carroll’s novel Alice’s Adventures in Wonderland, made in 1923. The main intention of the article is to analyze Nabokov’s translation strategies of domestication, realized in the text as substitution and localization, and to explain possible reasons for his decision in favour of almost complete Russification of the original. It is possible that Nabokov considered children’s attitude towards the final result as the most important part of the translation process. Thus, he used domesticated strategies to transfer for Russian children the humour, the originality and brightness of the paradoxical and attractive world of Lewis Carroll, his sense of the absurd and his amazing gift for games of logic and language, providing a recognizable and familiar atmosphere for the readers. Undoubtedly, his young Russian readers were able to identify themselves with the story and to comprehend the complex world created by Lewis Carroll. On the other hand, Nabokov refuses to oversimplify his translation or to patronize its young audience through simplistic translation solutions.

Simultaneous occurrence of subarachnoid hemorrhage and epistaxis due to ruptured petrous internal carotid artery aneurysm. Association with transsphenoidal surgery and radiation therapy. Case report

International Nuclear Information System (INIS)

Endo, Hidenori; Fujimura, Miki; Inoue, Takashi; Matsumoto, Yasushi; Ogawa, Yoshikazu; Kawagishi, Jun; Jokura, Hidefumi; Shimizu, Hiroaki; Tominaga, Teiji

2011-01-01

A 62-year-old woman presented with simultaneous subarachnoid hemorrhage (SAH) and massive epistaxis. The patient had been treated for pituitary prolactinoma by two transsphenoidal surgeries, gamma knife radiosurgery, and conventional radiation therapy since age 43 years. Cerebral angiography showed left petrous internal carotid artery (ICA) aneurysm with slight stenosis on the adjacent left petrous ICA. She underwent superficial temporal artery-middle cerebral artery (STA-MCA) double anastomosis with endovascular internal trapping without complication the day after onset. Postoperative course was uneventful; the patient did not develop symptomatic vasospasm, recurrent epistaxis, or cerebrospinal fluid rhinorrhea. Postoperative angiography demonstrated complete disappearance of the aneurysm with patent STA-MCA anastomosis. The patient was discharged 2 months after surgery without neurological deficit. The present case is extremely rare with simultaneous onset of SAH and epistaxis caused by ruptured petrous ICA aneurysm. The transsphenoidal surgeries and radiation therapies might have been critical in the formation of the petrous ICA aneurysm. (author)

Present developments in reaching an international consensus for a model-based approach to particle beam therapy.

Science.gov (United States)

Prayongrat, Anussara; Umegaki, Kikuo; van der Schaaf, Arjen; Koong, Albert C; Lin, Steven H; Whitaker, Thomas; McNutt, Todd; Matsufuji, Naruhiro; Graves, Edward; Mizuta, Masahiko; Ogawa, Kazuhiko; Date, Hiroyuki; Moriwaki, Kensuke; Ito, Yoichi M; Kobashi, Keiji; Dekura, Yasuhiro; Shimizu, Shinichi; Shirato, Hiroki

2018-03-01

Particle beam therapy (PBT), including proton and carbon ion therapy, is an emerging innovative treatment for cancer patients. Due to the high cost of and limited access to treatment, meticulous selection of patients who would benefit most from PBT, when compared with standard X-ray therapy (XRT), is necessary. Due to the cost and labor involved in randomized controlled trials, the model-based approach (MBA) is used as an alternative means of establishing scientific evidence in medicine, and it can be improved continuously. Good databases and reasonable models are crucial for the reliability of this approach. The tumor control probability and normal tissue complication probability models are good illustrations of the advantages of PBT, but pre-existing NTCP models have been derived from historical patient treatments from the XRT era. This highlights the necessity of prospectively analyzing specific treatment-related toxicities in order to develop PBT-compatible models. An international consensus has been reached at the Global Institution for Collaborative Research and Education (GI-CoRE) joint symposium, concluding that a systematically developed model is required for model accuracy and performance. Six important steps that need to be observed in these considerations include patient selection, treatment planning, beam delivery, dose verification, response assessment, and data analysis. Advanced technologies in radiotherapy and computer science can be integrated to improve the efficacy of a treatment. Model validation and appropriately defined thresholds in a cost-effectiveness centered manner, together with quality assurance in the treatment planning, have to be achieved prior to clinical implementation.

Making an impact: an adventure into international pharmacy.

Science.gov (United States)

Hitch, William; Ransom, Matthew

2009-01-01

To support a medical team, organized by Shoulder to Shoulder, with pharmacy services in an effort to expand ongoing health care to a rural community in Honduras. Pharmacy services in a temporary medical clinic in a schoolhouse in Colomarigua, a small mountain village in Honduras. Pharmacy services and medical care to address acute care needs of the people of Colomarigua, Honduras, during a week-long clinic. Interpreters assisted with patient counseling. Medication labels with pictures that connected doses to mealtimes increased patient understanding and the potential for medications to be dosed correctly. Fill lines were drawn on delivery devices for pediatric suspensions. An effort was made to avoid polypharmacy by communicating with physicians about the different prescriptions that were being prescribed in each household. Not applicable. Not applicable. We created a temporary clinic with a pharmacy and provided medical care to more than 600 children and adults in the surrounding regions. The medical team identified need for a feeding program, and local Shoulder to Shoulder teams began activities to support the community's development. Education programs were initiated to allow promising local children access to higher education. Challenges to providing optimal pharmaceutical care included language barriers, space and flow of the pharmacy, and a limited formulary. Benefits included gaining a whole new perspective on pharmacotherapy, health, and the importance of service to those in need whether abroad or at home.

Predictive and prognostic value of circulating nucleosomes and serum biomarkers in patients with metastasized colorectal cancer undergoing Selective Internal Radiation Therapy

International Nuclear Information System (INIS)

Fahmueller, Yvonne Nadine; Nagel, Dorothea; Hoffmann, Ralf-Thorsten; Tatsch, Klaus; Jakobs, Tobias; Stieber, Petra; Holdenrieder, Stefan

2012-01-01

Selective Internal Radiation Therapy (SIRT) is a new and effective locoregional anticancer therapy for colorectal cancer patients with liver metastases. Markers for prediction of therapy response and prognosis are needed for the individual management of those patients undergoing SIRT. Blood samples were prospectively and consecutively taken from 49 colorectal cancer patients with extensive hepatic metastases before, three, six, 24 and 48 h after SIRT to analyze the concentrations of nucleosomes and further laboratory parameters, and to compare them with the response to therapy regularly determined 3 months after therapy and with overall survival. Circulating nucleosomes, cytokeratin-19 fragments (CYFRA 21-1), carcinoembryonic antigen (CEA), C-reactive protein (CRP) and various liver markers increased already 24 h after SIRT. Pretherapeutical levels of CYFRA 21-1, CEA, cancer antigen 19-9 (CA 19-9), asparate-aminotransferase (AST) and lactate dehydrogenase (LDH) as well as 24 h values of nucleosomes were significantly higher in patients suffering from disease progression (N = 35) than in non-progressive patients (N = 14). Concerning overall survival, CEA, CA 19-9, CYFRA 21-1, CRP, LDH, AST, choline esterase (CHE), gamma-glutamyl-transferase, alkaline phosphatase, and amylase (all 0 h, 24 h) and nucleosomes (24 h) were found to be prognostic relevant markers in univariate analyses. In multivariate Cox-Regression analysis, the best prognostic model was obtained for the combination of CRP and AST. When 24 h values were additionally included, nucleosomes (24 h) further improved the existing model. Panels of biochemical markers are helpful to stratify pretherapeutically colorectal cancer patients for SIR-therapy and to early estimate the response to SIR-therapy

Effectiveness of hypnosis therapy and Gestalt therapy as depression treatments

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Elizabeth González-Ramírez

2017-03-01

Full Text Available We analyzed the effectiveness of two psychological therapies to treat depression in the Culiacan population, Mexico. According to criteria of MINI (international Neuropsychiatric interview, 30 individuals from a total of 300 were selected and diagnosed with some kind of depression. Patients were divided in three groups: 1 treatment with hypnosis therapy, 2 treatment with Gestalt-hypnosis therapy, and 3 control group. Before and after the treatments the Beck Anxiety Inventory (BAI was applied to know the depression level of the analyzed groups. The results show that the three groups were presenting a moderated level of depression. The groups under hypnosis therapy and Gestalt-hypnosis therapy show statistical differences between pre-test and post-test. The hypnosis therapy shows significant statistic differences to treat depression with respect to the other two groups. In conclusion, the therapeutic hypnosis is an effective treatment and has relevance to treat depression, while other therapeutic treatments tend to be slow and with minor result. This study is the first of this kind carried out in Culiacan in Sinaloa, Mexico.

Theranostic Nanoseeds for Efficacious Internal Radiation Therapy of Unresectable Solid Tumors

Science.gov (United States)

Moeendarbari, Sina; Tekade, Rakesh; Mulgaonkar, Aditi; Christensen, Preston; Ramezani, Saleh; Hassan, Gedaa; Jiang, Ruiqian; Öz, Orhan K.; Hao, Yaowu; Sun, Xiankai

2016-02-01

Malignant tumors are considered “unresectable” if they are adhere to vital structures or the surgery would cause irreversible damages to the patients. Though a variety of cytotoxic drugs and radiation therapies are currently available in clinical practice to treat such tumor masses, these therapeutic modalities are always associated with substantial side effects. Here, we report an injectable nanoparticle-based internal radiation source that potentially offers more efficacious treatment of unresectable solid tumors without significant adverse side effects. Using a highly efficient incorporation procedure, palladium-103, a brachytherapy radioisotope in clinical practice, was coated to monodispersed hollow gold nanoparticles with a diameter about 120 nm, to form 103Pd@Au nanoseeds. The therapeutic efficacy of 103Pd@Au nanoseeds were assessed when intratumorally injected into a prostate cancer xenograft model. Five weeks after a single-dose treatment, a significant tumor burden reduction (>80%) was observed without noticeable side effects on the liver, spleen and other organs. Impressively, >95% nanoseeds were retained inside the tumors as monitored by Single Photon Emission Computed Tomography (SPECT) with the gamma emissions of 103Pd. These findings show that this nanoseed-based brachytherapy has the potential to provide a theranostic solution to unresectable solid tumors.

Adjuvant therapy of Dukes' C colon cancer by intra-arterial P-32 colloid for internal radiation therapy of the liver

Energy Technology Data Exchange (ETDEWEB)

Grady, E.D.

1984-09-01

To prevent probable occult metastatic liver cancer from progressing to clinical disease, the author used internal radiation therapy as an effective adjuvant to surgical excision of primary Dukes' C colonic cancer. A calculated radiation dose of 5000 rads was delivered to the liver by injecting radioactive 32-P chromic phosphate colloid through the superior mesenteric and celiac arteries. When this was done, the colloid passed through the intestines and was mixed thoroughly with the blood and delivered to the liver by the portal vein. The Kupffer cells in the liver trapped the colloid, and a minimum amount passed through the liver and got into the general circulation. This kept the amount of colloid deposited in the bone marrow to a minimum. In a phase-I pilot study in which nine patients were treated, no serious side effects were noted. In eight patients, the liver has remained free of cancer for more than 1 year.

Conditional internalization of PEGylated nanomedicines by PEG engagers for triple negative breast cancer therapy

Science.gov (United States)

Su, Yu-Cheng; Burnouf, Pierre-Alain; Chuang, Kuo-Hsiang; Chen, Bing-Mae; Cheng, Tian-Lu; Roffler, Steve R.

2017-06-01

Triple-negative breast cancer (TNBC) lacks effective treatment options due to the absence of traditional therapeutic targets. The epidermal growth factor receptor (EGFR) has emerged as a promising target for TNBC therapy because it is overexpressed in about 50% of TNBC patients. Here we describe a PEG engager that simultaneously binds polyethylene glycol and EGFR to deliver PEGylated nanomedicines to EGFR+ TNBC. The PEG engager displays conditional internalization by remaining on the surface of TNBC cells until contact with PEGylated nanocarriers triggers rapid engulfment of nanocargos. PEG engager enhances the anti-proliferative activity of PEG-liposomal doxorubicin to EGFR+ TNBC cells by up to 100-fold with potency dependent on EGFR expression levels. The PEG engager significantly increases retention of fluorescent PEG probes and enhances the antitumour activity of PEGylated liposomal doxorubicin in human TNBC xenografts. PEG engagers with specificity for EGFR are promising for improved treatment of EGFR+ TNBC patients.

Programme of Action for Cancer Therapy (PACT)

International Nuclear Information System (INIS)

2008-01-01

This document is an informational bulletin about the problems associated with access to diagnosis and therapy of cancers in developing countries and the role of the Program of Action for Cancer Therapy (PACT) of the International Atomic Energy Agency

Effectiveness of Dry Cow Therapy Comprising Antibiotic Treatment, Internal Teat Sealant, and α-Tocopherol Against New Intramammary Infections in Cows

Directory of Open Access Journals (Sweden)

Cengiz Mehmet

2015-04-01

Full Text Available The aim of this study was to evaluate the preventive effectiveness of dry cow therapy based on antibiotic, internal teat sealant, and α-tocopherol administered separately or in various combinations at drying-off The study was performed on 322 uninfected quarters of 95 cows originating from three dairy herds. The new intramammary infection rates after calving were measured to evaluate the effectiveness. The quarters were divided into six groups differing in treatment, namely: control group (group C, n = 40 and five treatment groups. Treatment groups were arranged as follows: group A (antibiotic alone, n = 81, group AS (antibiotic + sealant, n = 40, group AST (antibiotic + sealant + α-tocopherol, n = 40, group T (α-tocopherol alone, n = 40, group S (sealant alone, n = 81. New infection rate amounted to 47.5% in group C. The treatment in group AST significantly prevented from the occurrence of new intramammary infections (12.5%, P 0.05, although the use of the sealant alone (group S decreased the risk of new infection (24.7%, P 0.05. Increased α-tocopherol level (P < 0.05 was detected after calving in the quarters from cows that received α-tocopherol injections. In conclusion, the combination of antibiotic, internal teat sealant, and α-tocopherol used in dry cow therapy showed a significantly better preventive effect against new intramammary infections, than the therapeutics administered separately.

Journal of Proton Therapy

Directory of Open Access Journals (Sweden)

Editorial Office

2015-01-01

Full Text Available Journal of Proton Therapy (JPT is an international open access, peer-reviewed journal, which publishes original research, technical reports, reviews, case reports, editorials, and other materials on proton therapy with focus on radiation oncology, medical physics, medical dosimetry, and radiation therapy.No article processing/submission feeNo publication feePeer-review completion within 3-6 weeksImmediate publication after the completion of final author proofreadDOI assignment for each published articleFree access to published articles for all readers without any access barriers or subscriptionThe views and opinions expressed in articles are those of the author/s and do not necessarily reflect the policies of the Journal of Proton Therapy.Authors are encouraged to submit articles for publication in the inaugural issue of the Journal of Proton Therapy by online or email to editor@protonjournal.comOfficial Website of Journal of Proton Therapy: http://www.protonjournal.org/

When does atopic dermatitis warrant systemic therapy?

DEFF Research Database (Denmark)

Simpson, Eric L; Bruin-Weller, Marjolein; Flohr, Carsten

2017-01-01

therapy in AD and provide a framework for evaluation before making this therapeutic decision with the patient. METHODS: A subgroup of the International Eczema Council determined aspects to consider before prescribing systemic therapy. Topics were assigned to expert reviewers who performed a topic...... systemic therapy include considering alternate or concomitant diagnoses, avoiding trigger factors, optimizing topical therapy, ensuring adequate patient/caregiver education, treating coexistent infection, assessing the impact on quality of life, and considering phototherapy. LIMITATIONS: Our work...

Extending Parent–Child Interaction Therapy for Early Childhood Internalizing Problems: New Advances for an Overlooked Population

Science.gov (United States)

Puliafico, Anthony C.; Kurtz, Steven M. S.; Pincus, Donna B.; Comer, Jonathan S.

2014-01-01

Although efficacious psychological treatments for internalizing disorders are now well established for school-aged children, until recently there have regrettably been limited empirical efforts to clarify indicated psychological intervention methods for the treatment of mood and anxiety disorders presenting in early childhood. Young children lack many of the developmental capacities required to effectively participate in established treatments for mood and anxiety problems presenting in older children, making simple downward extensions of these treatments for the management of preschool internalizing problems misguided. In recent years, a number of research groups have successfully adapted and modified parent–child interaction therapy (PCIT), originally developed to treat externalizing problems in young children, to treat various early internalizing problems with a set of neighboring protocols. As in traditional PCIT, these extensions target child symptoms by directly reshaping parent–child interaction patterns associated with the maintenance of symptoms. The present review outlines this emerging set of novel PCIT adaptations and modifications for mood and anxiety problems in young children and reviews preliminary evidence supporting their use. Specifically, we cover (a) PCIT for early separation anxiety disorder; (b) the PCIT-CALM (Coaching Approach behavior and Leading by Modeling) Program for the full range of early anxiety disorders; (c) the group Turtle Program for behavioral inhibition; and (d) the PCIT-ED (Emotional Development) Program for preschool depression. In addition, emerging PCIT-related protocols in need of empirical attention—such as the PCIT-SM (selective mutism) Program for young children with SM—are also considered. Implications of these protocols are discussed with regard to their unique potential to address the clinical needs of young children with internalizing problems. Obstacles to broad dissemination are addressed, and we consider

Extending parent-child interaction therapy for early childhood internalizing problems: new advances for an overlooked population.

Science.gov (United States)

Carpenter, Aubrey L; Puliafico, Anthony C; Kurtz, Steven M S; Pincus, Donna B; Comer, Jonathan S

2014-12-01

Although efficacious psychological treatments for internalizing disorders are now well established for school-aged children, until recently there have regrettably been limited empirical efforts to clarify indicated psychological intervention methods for the treatment of mood and anxiety disorders presenting in early childhood. Young children lack many of the developmental capacities required to effectively participate in established treatments for mood and anxiety problems presenting in older children, making simple downward extensions of these treatments for the management of preschool internalizing problems misguided. In recent years, a number of research groups have successfully adapted and modified parent-child interaction therapy (PCIT), originally developed to treat externalizing problems in young children, to treat various early internalizing problems with a set of neighboring protocols. As in traditional PCIT, these extensions target child symptoms by directly reshaping parent-child interaction patterns associated with the maintenance of symptoms. The present review outlines this emerging set of novel PCIT adaptations and modifications for mood and anxiety problems in young children and reviews preliminary evidence supporting their use. Specifically, we cover (a) PCIT for early separation anxiety disorder; (b) the PCIT-CALM (Coaching Approach behavior and Leading by Modeling) Program for the full range of early anxiety disorders; (c) the group Turtle Program for behavioral inhibition; and (d) the PCIT-ED (Emotional Development) Program for preschool depression. In addition, emerging PCIT-related protocols in need of empirical attention--such as the PCIT-SM (selective mutism) Program for young children with SM--are also considered. Implications of these protocols are discussed with regard to their unique potential to address the clinical needs of young children with internalizing problems. Obstacles to broad dissemination are addressed, and we consider

Colonial adventures in tropical agriculture

NARCIS (Netherlands)

Buelens, Frans; Frankema, Ewout

2016-01-01

How profitable were foreign investments in plantation agriculture in the Netherlands Indies during the late colonial era? We use a new dataset of monthly quoted stock prices and dividends of international companies at the Brussels stock exchange to estimate the returns to investment in tropical

Modern radiation therapy for primary cutaneous lymphomas

DEFF Research Database (Denmark)

Specht, Lena; Dabaja, Bouthaina; Illidge, Tim

2015-01-01

Primary cutaneous lymphomas are a heterogeneous group of diseases. They often remain localized, and they generally have a more indolent course and a better prognosis than lymphomas in other locations. They are highly radiosensitive, and radiation therapy is an important part of the treatment......, either as the sole treatment or as part of a multimodality approach. Radiation therapy of primary cutaneous lymphomas requires the use of special techniques that form the focus of these guidelines. The International Lymphoma Radiation Oncology Group has developed these guidelines after multinational...... meetings and analysis of available evidence. The guidelines represent an agreed consensus view of the International Lymphoma Radiation Oncology Group steering committee on the use of radiation therapy in primary cutaneous lymphomas in the modern era....

[Profound meaning of acupuncture taboos in Internal Classic based on the fault of reinforcing and reducing technique by mind conduction of acupuncture therapy].

Science.gov (United States)

Qin, Yuge; Wang, Feng; Qin, Yuheng; Li, Li; Li, Mei

2016-05-01

By analyzing the acupuncture taboos in Neijing (Internal Classic) on clinical application of mind conduction of acupuncture therapy in going against the actual situation, astronomy and others, it is found that the relevant acupuncture taboo implies many subtle mysteries of human body, qi, mind and astronomy, which have not been discovered yet in modern science and are very significant in qi protection. In Neijing, the acupuncture physicians have been highly required in the mind treatment, in which, accurately regulating qi circulation is the target in the treatment. The mind conduction is used for qi circulation to accomplish accurately the reinforcing or reducing in the deficiency or excess condition. All of the taboos are provided to normalize the accuracy of reinforcing and reducing technique of acupuncture therapy and avoid the damage of qi in human body. Hence, those taboos must be obeyed so as to prevent from serious consequence and ensure the safety of this acupuncture therapy.

The Paediatric Rheumatology International Trials Organisation provisional criteria for the evaluation of response to therapy in juvenile dermatomyositis.

Science.gov (United States)

Ruperto, Nicolino; Pistorio, Angela; Ravelli, Angelo; Rider, Lisa G; Pilkington, Clarissa; Oliveira, Sheila; Wulffraat, Nico; Espada, Graciela; Garay, Stella; Cuttica, Ruben; Hofer, Michael; Quartier, Pierre; Melo-Gomes, Jose; Reed, Ann M; Wierzbowska, Malgorzata; Feldman, Brian M; Harjacek, Miroslav; Huppertz, Hans-Iko; Nielsen, Susan; Flato, Berit; Lahdenne, Pekka; Michels, Harmut; Murray, Kevin J; Punaro, Lynn; Rennebohm, Robert; Russo, Ricardo; Balogh, Zsolt; Rooney, Madeleine; Pachman, Lauren M; Wallace, Carol; Hashkes, Philip; Lovell, Daniel J; Giannini, Edward H; Gare, Boel Andersson; Martini, Alberto

2010-11-01

To develop a provisional definition for the evaluation of response to therapy in juvenile dermatomyositis (DM) based on the Paediatric Rheumatology International Trials Organisation juvenile DM core set of variables. Thirty-seven experienced pediatric rheumatologists from 27 countries achieved consensus on 128 difficult patient profiles as clinically improved or not improved using a stepwise approach (patient's rating, statistical analysis, definition selection). Using the physicians' consensus ratings as the "gold standard measure," chi-square, sensitivity, specificity, false-positive and-negative rates, area under the receiver operating characteristic curve, and kappa agreement for candidate definitions of improvement were calculated. Definitions with kappa values >0.8 were multiplied by the face validity score to select the top definitions. The top definition of improvement was at least 20% improvement from baseline in 3 of 6 core set variables with no more than 1 of the remaining worsening by more than 30%, which cannot be muscle strength. The second-highest scoring definition was at least 20% improvement from baseline in 3 of 6 core set variables with no more than 2 of the remaining worsening by more than 25%, which cannot be muscle strength (definition P1 selected by the International Myositis Assessment and Clinical Studies group). The third is similar to the second with the maximum amount of worsening set to 30%. This indicates convergent validity of the process. We propose a provisional data-driven definition of improvement that reflects well the consensus rating of experienced clinicians, which incorporates clinically meaningful change in core set variables in a composite end point for the evaluation of global response to therapy in juvenile DM. Copyright © 2010 by the American College of Rheumatology.

HAE international home therapy consensus document

Directory of Open Access Journals (Sweden)

Longhurst Hilary J

2010-07-01

Full Text Available Abstract Hereditary angioedema (C1 inhibitor deficiency, HAE is associated with intermittent swellings which are disabling and may be fatal. Effective treatments are available and these are most useful when given early in the course of the swelling. The requirement to attend a medical facility for parenteral treatment results in delays. Home therapy offers the possibility of earlier treatment and better symptom control, enabling patients to live more healthy, productive lives. This paper examines the evidence for patient-controlled home treatment of acute attacks ('self or assisted administration' and suggests a framework for patients and physicians interested in participating in home or self-administration programmes. It represents the opinion of the authors who have a wide range of expert experience in the management of HAE.

Comparison of cephalonium alone and in combination with an internal teat sealant for dry cow therapy in seasonally calving dairy cows.

Science.gov (United States)

Bates, A J; Chambers, G; Laven, R A

2016-03-01

To assess the effect of combining an internal teat sealant (ITS) and a long-acting cephalonium-based dry cow therapy (DCT) on the prevalence of cows with a somatic cell count (SCC) >150,000 cells/mL 60-80 days after calving, and the incidence of clinical mastitis diagnosed by farm staff in the first 100 days after calving. Cows from a spring-calving, pasture-based, dairy farm in the South Canterbury region of New Zealand were randomly allocated to receive cephalonium DCT (n=289) or cephalonium and internal teat sealant (n=304) at the end of lactation. Cows were inspected twice daily by farm staff during the dry period and following calving for signs of mastitis. Individual SCC were determined from herd tests conducted in the previous lactation and following calving. Logistic regression models were used to determine relationships with the prevalence of cows with a SCC >150,000 cells/mL after calving, and survival analysis was used to model time to the first case of clinical mastitis following calving at the cow and quarter level. The OR for a cow with a SCC >150,000 cells/mL after calving, including age and individual SCC in the preceding lactation in the model, was 0.53 (95% CI=0.32-0.89) for cows treated with combination therapy compared to cows receiving cephalonium (p=0.017). At the cow level, including age and preceding SCC in the model, the hazard ratio for diagnosis of clinical mastitis by farm staff in the first 100 days of lactation was 0.60 (95% CI=0.39-0.98) for cows treated with combination therapy compared to cows receiving cephalonium (p=0.04). At the quarter level, the hazard ratio for diagnosis of clinical mastitis, with age included in the model, was 0.41 (95% CI=0.23-0.74) for the combination therapy compared to cephalonium alone (pmastitis diagnosed by farm staff in the 100 days after calving, and the prevalence of cows with a SCC >150,000 cells/mL 60-80 days after calving. This study adds to the evidence that the prevention of intra mammary

Tourists’ Satisfaction at Trijuginarayan: An Emerging Spiritual and Adventure Tourist Destination in Garhwal Himalaya India

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S.C. Bagri

2015-10-01

Full Text Available Tourists’ satisfaction has been acknowledged as one of the most important elements of competitive advantage and formulating effective destination management strategies because it is a reliable standard to evaluate performance of tangible and intangible elements of tourism products and services. The purpose of this study is to investigate tourists’ satisfaction by examining the relationship between destination attribute importance and performance in a tourist destination. Trijuginarayan, an emerging spiritual and adventure tourist destination located in Garhwal Himalaya in Uttarakhand state of India was selected as the study area for this research. Importance-Performance Analysis was employed to examine the relationship between importance and performance of various destination attributes. Results revealed that attributes related to tourism product of spiritual and cultural nature, atmosphere and climate, a variety of tourist activities, hospitality and safety are significant factors in determining tourist satisfaction, whereas basic facilities such as accommodation, transportation, tourism infrastructure and hygiene and sanitation at destination are of significant importance in satisfaction evaluation. Findings also reveal that tourists were satisfied with the core products, but were dissatisfied with basic tourist facilities offered at the destination. The findings alert concerned tourism stakeholders for outlining effective strategies for holistic development and improving performance of attributes in a given destination.

A collaborative adventure

CERN Multimedia

2014-01-01

At the start of a new year, I’d like to wish all of you and your families a happy, successful and peaceful 2014. It’s a year that holds particular significance for CERN, as on 29 September it will be 60 years since the Organization was founded.   As CERN turns 60, it is still going strong, maintaining its underlying attraction of international collaboration for basic science. Since its foundation in 1954, it has grown steadily and this year begins well as we welcome a new Member State, Israel. CERN and Israel already have a long history of mutual collaboration and now we can look forward to increasingly fruitful scientific cooperation. Israel’s accession brings the total number of Member States to 21, and other countries are in the stages leading up to becoming Members or Associates, while still others are expressing interest. CERN is becoming a global success, while retaining its original, European flavour. This year’s events for the 60th anniversary ...

Postgraduate Training in Music Therapy Research in Aalborg University: An International Enterprise

DEFF Research Database (Denmark)

Bonde, Lars Ole

2011-01-01

Short report on dissemination and careers of PhD candidates in Music Therapy from Aalborg University 1998-2006......Short report on dissemination and careers of PhD candidates in Music Therapy from Aalborg University 1998-2006...

Impact of International Collaborative Project on Cultural Competence among Occupational Therapy Students

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Divya Sood OTD, OTR/L

2014-07-01

Full Text Available Occupational therapy (OT educators recognize a need to ensure that OT students are culturally competent. The researchers developed the International Collaborative Project on Cultural Competence (ICPCC to help students understand the impact of cultural context on client care. Entry-level MOT students from a university in the US (N = 18 collaborated with BOT students (N = 4 and advanced MOT students (N = 9 from two universities in India using an online course management system WebCT. The study explored the impact of the ICPCC on OT students’ cultural competence and discusses students’ perceptions of culture on the OT process. The Inventory for Assessing the Process of Cultural Competence Among Health Care Professionals Revised© measured students’ cultural competence at baseline and immediately after participation in the ICPCC. Qualitative data was collected using a Self-Reflection Form. There was an increase in the cultural competence scores among all three groups of students after participating in the ICPCC at p value < .05. Three themes emerged from the qualitative data analysis: meaning of the term culture, impact of cultural on client- centered practice, and impact of cultural on OT outcomes. OT students recognized the role that cultural differences play in OT evaluation and intervention.

Results of a Quality Assurance Review of External Beam Radiation Therapy in the International Society of Paediatric Oncology (Europe) Neuroblastoma Group's High-risk Neuroblastoma Trial: A SIOPEN Study

International Nuclear Information System (INIS)

Gaze, Mark N.; Boterberg, Tom; Dieckmann, Karin; Hörmann, Marcus; Gains, Jennifer E.; Sullivan, Kevin P.; Ladenstein, Ruth

2013-01-01

Purpose: Radiation therapy is important for local control in neuroblastoma. This study reviewed the compliance of plans with the radiation therapy guidelines of the International Society of Paediatric Oncology (Europe) Neuroblastoma Group (SIOPEN) High-Risk Trial protocol. Methods and Materials: The SIOPEN trial central electronic database has sections to record diagnostic imaging and radiation therapy planning data. Individual centers may upload data remotely, but not all centers involved in the trial chose to use this system. A quality scoring system was devised based on how well the radiation therapy plan matched the protocol guidelines, to what extent deviations were justified, and whether adverse effects may result. Central review of radiation therapy planning was undertaken retrospectively in 100 patients for whom complete diagnostic and treatment sets were available. Data were reviewed and compared against protocol guidelines by an international team of radiation oncologists and radiologists. For each patient in the sample, the central review team assigned a quality assurance score. Results: It was found that in 48% of patients there was full compliance with protocol requirements. In 29%, there were deviations for justifiable reasons with no likely long-term adverse effects resulting. In 5%, deviations had occurred for justifiable reasons, but that might result in adverse effects. In 1%, there was a deviation with no discernible justification, which would not lead to long-term adverse events. In 17%, unjustified deviations were noted, with a risk of an adverse outcome resulting. Conclusions: Owing to concern over the proportion of patients in whom unjustified deviations were observed, a protocol amendment has been issued. This offers the opportunity for central review of radiation therapy plans before the start of treatment and the treating clinician a chance to modify plans.

Why ghosts don’t touch: a tale of two adventurers falling one after another into a black hole

International Nuclear Information System (INIS)

Kassner, Klaus

2017-01-01

The case for the utility of Kruskal–Szekeres coordinates in the classroom made by Augousti et al in this journal (2012 Eur. J. Phys. 33 1–11) is strengthened by extending their discussion beyond the event horizon of the black hole. Observations made by two adventurers following one another into a Schwarzschild black hole are examined in terms of these nonsingular coordinates. Two scenarios are considered, the first corresponding to one observer following the other closely, the second to a significant distance between the two of them, precluding the existence of a common inertial system. In particular, the concepts of distance and temporal separation near the horizon and the redshift of the first infaller's image as seen by the second are investigated. The results show that the notion of ‘touching ghosts’ does not correspond to the local physics of two observers falling into a black hole. The story line is interesting enough and the mathematical details are sufficiently simple to use the example in a general relativity course, even at the undergraduate level. (paper)

Kundalini yoga as a support therapy for cancer patients

OpenAIRE

Kröneck, Mia

2016-01-01

This study was designed to describe cancer patient’s experience of kundalini yoga and its effect on their internal coping resources. The intention of this study is to put forward kundalini yoga as a support therapy for cancer patients for improving their wellbeing during active cancer treatment. This is a descriptive study. An academic literature review was conducted for cancer, cancer treatment, internal coping resources and yoga as therapy topics. Four voluntary female cancer patients (...

The Intern Studio: A Pilot Study.

Science.gov (United States)

Wix, Linney

1995-01-01

Describes and discusses the Intern Studio Project, which consists of the provision of regular open studio time for art therapy interns in a state university graduate program. Psychological and artistic bases for the open studio approach are discussed, and include the relational approach, Hillman's essentialist paradigm, and series and context…

Adventure-Based Counseling: An Adlerian "Natural High."

Science.gov (United States)

Gillis, H. Lee; Dagley, John

Special characteristics of action-oriented approaches to therapy, cautions and tips for using these approaches, and sample activities are provided in this guide. An introductory section explains the relationship of action-based counseling to the traditional action-oriented methods and principles of Adlerian psychology and emphasizes the merit of…

International students of speech and language therapy in the UK: do we meet their needs?

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Marshall, Julie; Goldbart, Juliet; Evans, Ruth

2004-01-01

Informal evidence suggests that many Speech and Language Therapy (SLT) students from outside of the UK and/or Republic of Ireland who come to the UK either do not return to their home country on qualification or do not practise as SLTs in the public sector. Many factors may contribute to this situation. Concern that it may result in part from a poor match between UK SLT education and the demands of the role in other countries led the Royal College of Speech and Language Therapists (RCSLT) to fund a study of international SLT students' experiences of UK qualifying courses. To discover and describe the experiences, views and expectations of current and past international students studying SLT in the UK and past international students' experiences, views and expectations of practising as SLTS, both inside and outside the UK. To consider the implications of the findings for (1) international students planning to work as SLTs; (2) UK SLT students planning to practise outside the UK; and (3) all those involved in SLT education: educational institutions; supervising SLTs; RCSLT. The study involved distributing 166 postal questionnaires (some directly to (ex)students and some to their Higher Education Institutes, or HEIs) and carrying out 23 interviews, with both current students and those qualifying since May 1994. Quantitative analysis was carried out using SPSS using descriptive statistics. Qualitative analysis used content and thematic analyses. Seventy-one questionnaires were received from current and past students, representing a minimum response rate of 43%. (It was not possible to verify exactly how many questionnaires were distributed by HEIs.) The results describe the diverse range of respondents' experiences of studying and working in the UK, their views of working in their home countries and the UK, and their suggestions about strategies that might be adopted to support them further. The results revealed that students come from a wide diversity of countries

Introduction to Special Issue: A Review of the International Classification of Functioning, Disability and Health and Physical Therapy over the Years.

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Escorpizo, Reuben; Bemis-Dougherty, Anita

2015-12-01

The International Classification of Functioning, Disability and Health (ICF) of the World Health Organization was developed as a common framework to understand health and to describe the impact of health condition on functioning. The purpose of this paper is to summarize the literature on the use of the ICF in physical therapy practice and research. We performed a scoping-narrative review and searched for relevant English language articles from 2001 to 2012 in multiple databases that included MEDLINE, PsycINFO, PubMed and Physiotherapy Evidence Database. Our keywords for the search consisted of ['physical therapy' OR 'physiotherapy'] AND ['ICF']. All types of articles were considered. We found 268 articles; out of which, 79 were reviewed. The years with most publications were 2011 (n = 16), 2008 (n = 15) and 2010 and 2012 (both with n = 13). Publications mostly came from the United States with 27% of the articles. The journal Physical Therapy leads with almost a third of ICF-related physical therapy publications. The ICF has been mostly used in studies of musculoskeletal and neuromuscular conditions. We found a wide array of application of the ICF in research, clinical practice and teaching (classroom and clinical education). Emerging topics included using the ICF in resource allocation and prevention and wellness. The use of the ICF in physical therapy practice and research is promising and continues to evolve. With recent developments in ICF-based measurement and integration in assessment tools for use in the clinics, research and teaching, the need to show the added value of using the ICF in practice and research remains. Copyright © 2013 John Wiley & Sons, Ltd.

Altjeringa and didgeridoo: Australian Identity Devices on Polyphonic Spatiality of The Adventures of Priscilla, Queen of the Desert, Stephan Elliott

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Jorge Alves Santana

2016-06-01

Full Text Available http://dx.doi.org/10.5007/2175-8026.2016v69n2p127 The Adventures of Priscilla, Queen of the Desert (1994 is an Australian film directed by Stephan Elliott. It expresses socio- and aesthetically a perspective of devices that produce contemporary subjectivities in Australia. In this article, some aspects of the production of such subjectivities shall be discussed in terms of possible cross mobilities, present in relations strained by spatiality - in their lieux and non-lieux, lieux lisse and lieux strié (AUGÉ, 1992; 1997; 2006; Deleuze, 1997 - traveled by the trio of protagonists who, in the trip from Sydney to Alice Springs, meet an Aboriginal community in the heart of the Outback. Among Altjeringa and the didgeridoo, we will follow this meeting between homoaffective and ancestral identities, which, on a certain semantic level of this film, indicates contexts of political and cultural negotiations in the historical and imaginative nation building process (Anderson, 2006, carried out by the stratified Australian society.

Delineation of Internal Mammary Nodal Target Volumes in Breast Cancer Radiation Therapy

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Jethwa, Krishan R.; Kahila, Mohamed M. [Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota (United States); Hunt, Katie N. [Department of Radiology, Mayo Clinic, Rochester, Minnesota (United States); Brown, Lindsay C.; Corbin, Kimberly S.; Park, Sean S.; Yan, Elizabeth S. [Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota (United States); Boughey, Judy C. [Department of Surgery, Mayo Clinic, Rochester, Minnesota (United States); Mutter, Robert W., E-mail: mutter.robert@mayo.edu [Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota (United States)

2017-03-15

Purpose: The optimal clinical target volume for internal mammary (IM) node irradiation is uncertain in an era of increasingly conformal volume-based treatment planning for breast cancer. We mapped the location of gross internal mammary lymph node (IMN) metastases to identify areas at highest risk of harboring occult disease. Methods and Materials: Patients with axial imaging of IMN disease were identified from a breast cancer registry. The IMN location was transferred onto the corresponding anatomic position on representative axial computed tomography images of a patient in the treatment position and compared with consensus group guidelines of IMN target delineation. Results: The IMN location in 67 patients with 130 IMN metastases was mapped. The location was in the first 3 intercostal spaces in 102 of 130 nodal metastases (78%), whereas 18 of 130 IMNs (14%) were located caudal to the third intercostal space and 10 of 130 IMNs (8%) were located cranial to the first intercostal space. Of the 102 nodal metastases within the first 3 intercostal spaces, 54 (53%) were located within the Radiation Therapy Oncology Group consensus volume. Relative to the IM vessels, 19 nodal metastases (19%) were located medially with a mean distance of 2.2 mm (SD, 2.9 mm) whereas 29 (28%) were located laterally with a mean distance of 3.6 mm (SD, 2.5 mm). Ninety percent of lymph nodes within the first 3 intercostal spaces would have been encompassed within a 4-mm medial and lateral expansion on the IM vessels. Conclusions: In women with indications for elective IMN irradiation, a 4-mm medial and lateral expansion on the IM vessels may be appropriate. In women with known IMN involvement, cranial extension to the confluence of the IM vein with the brachiocephalic vein with or without caudal extension to the fourth or fifth interspace may be considered provided that normal tissue constraints are met.

Conceptualising professionalism in occupational therapy through a Western lens.

Science.gov (United States)

Hordichuk, Chelsea J; Robinson, Allison J; Sullivan, Theresa M

2015-06-01

The term professionalism is embedded within curriculum and occupational therapy documents, yet, explicit discussion of the concept is lacking in the literature. This paper strives for a greater understanding of how professionalism is currently conceptualised within Western occupational therapy literature. A broad literature search was conducted and included international peer-reviewed and grey literature from Western cultures including Australia, Canada, New Zealand, the United Kingdom and the United States. To enrich understanding, some documents from medicine were also included. Professionalism is widely upheld as a core construct of occupational therapy. However, an evidence-based consensus of the specific elements of professionalism guiding occupational therapy practice is lacking. Currently, understanding of professionalism is largely based on multiple, isolated concepts presented in Western professional association documents. Acknowledging the multifaceted and multicultural nature of professionalism is essential to begin systematically delineating and conceptualising elements of professionalism specific to occupational therapy. This review has been conducted from a solely Western cultural lens. Additional work to highlight differences specific to international contexts, cultures, and societal influences is needed to enrich the understanding of professionalism in occupational therapy practice. © 2015 Occupational Therapy Australia.

Androgen deprivation therapy (castration therapy and pedophilia: What’s new

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Mauro Silvani

2015-09-01

Full Text Available Andrology is a constantly evolving discipline, embracing social problems like pedophilia and its pharmacological treatment. With regard to chemical castration, the andrologist may perform an important role as part of a team of specialists. At present, no knowledge is available regarding hormonal, chromosomal or genetic alterations involved in pedophilia. International legislation primarily aims to defend childhood, but does not provide for compulsory treatment. We reviewed international literature that, at present, only comprises a few reports on research concerning androgen deprivation. Most of these refer to the use of leuprolide acetate, rather than medroxyprogesterone and cyproterone acetate, which present a larger number of side effects. Current opinions on chemical castration for pedophilia are discordant. Some surveys confirm that therapy reduces sexual thoughts and fantasies, especially in recidivism. On the other hand, some authors report that chemical castration does not modify the pedophile’s personality. In our opinion, once existing legislation has changed, andrologists could play a significant role in the selection of patients to receive androgen deprivation therapy, due in part to their knowledge about its action and side effects.

Delphi-RAND consensus of the Spanish Society of Internal Medicine on the controversies in anticoagulant therapy and prophylaxis in medical diseases. INTROMBIN Project (Uncertainty in thromboprophylaxis in internal medicine).

Science.gov (United States)

Ruiz-Ruiz, F; Medrano, F J; Navarro-Puerto, M A; Rodríguez-Torres, P; Romero-Alonso, A; Santos-Lozano, J M; Alonso-Ortiz Del Rio, C; Varela-Aguilar, J M; Calderón, E J; Marín-León, I

2018-05-21

The aim of this study was to determine the opinion of internists on the management of anticoagulation and thromboembolism prophylaxis in complex clinical scenarios in which the risk-benefit ratio of surgery is narrow and to develop a consensus document on the use of drugs anticoagulant therapy in this patient group. To this end, we identified by consensus the clinical areas of greatest uncertainty, a survey was created with 20 scenarios laid out in 40 clinical questions, and we reviewed the specific literature. The survey was distributed among the internists of the Spanish Society of Internal Medicine (SEMI) and was completed by 290 of its members. The consensus process was implemented by changing the Delphi-RAND appropriateness method in an anonymous, double-round process that enabled an expert panel to identify the areas of agreement and uncertainty. In our case, we also added the survey results to the panel, a methodological innovation that helps provide additional information on the standard clinical practice. The result of the process is a set of 19 recommendations formulated by SEMI experts, which helps establish guidelines for action on anticoagulant therapy in complex scenarios (high risk or active haemorrhage, short life expectancy, coexistence of antiplatelet therapy or comorbidities such as kidney disease and liver disease), which are not uncommon in standard clinical practice. Copyright © 2018 Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI). All rights reserved.

Current views of the risk factors, diagnosis, and therapy of Alzheimer's disease (according to the proceedings of the Alzheimer's Association International Conference, London, 2017

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N. N. Koberskaya

2017-01-01

Full Text Available The paper presents an overview of new methods for the diagnosis, treatment, and prevention of Alzheimer's disease (AD according to the proceeding of the Alzheimer's Association International Conference that was held in London on 16 to 20 July 2017. AD is the most common cause of dementia, especially in the elderly. The data of epidemiological and genetic studies and risk factors for AD were considered. Great attention was paid to the relationship of AD to cerebrovascular disorders, the differential diagnosis of AD with dementia in other nosological entities (dementia with Lewy bodies, frontotemporal dementia, cerebrovascular disease. New approaches to managing patients with AD were discussed. Current ideas about therapy for BA, symptomatic and pathogenetic methods for its treatment, combined therapy were outlined.

Outcomes of physical therapy, speech pathology, and occupational therapy for people with motor neuron disease: a systematic review.

Science.gov (United States)

Morris, Meg E; Perry, Alison; Bilney, Belinda; Curran, Andrea; Dodd, Karen; Wittwer, Joanne E; Dalton, Gregory W

2006-09-01

This article describes a systematic review and critical evaluation of the international literature on the effects of physical therapy, speech pathology, and occupational therapy for people with motor neuron disease (PwMND). The results were interpreted using the framework of the International Classification of Functioning, Disability and Health. This enabled us to summarize therapy outcomes at the level of body structure and function, activity limitations, participation restrictions, and quality of life. Databases searched included MEDLINE, PUBMED, CINAHL, PSYCInfo, Data base of Abstracts of Reviews of Effectiveness (DARE), The Physiotherapy Evidence data base (PEDro), Evidence Based Medicine Reviews (EMBASE), the Cochrane database of systematic reviews, and the Cochrane Controlled Trials Register. Evidence was graded according to the Harbour and Miller classification. Most of the evidence was found to be at the level of "clinical opinion" rather than of controlled clinical trials. Several nonrandomized small group and "observational studies" provided low-level evidence to support physical therapy for improving muscle strength and pulmonary function. There was also some evidence to support the effectiveness of speech pathology interventions for dysarthria. The search identified a small number of studies on occupational therapy for PwMND, which were small, noncontrolled pre-post-designs or clinical reports.

Modern Radiation Therapy for Nodal Non-Hodgkin Lymphoma—Target Definition and Dose Guidelines From the International Lymphoma Radiation Oncology Group

Energy Technology Data Exchange (ETDEWEB)

Illidge, Tim, E-mail: Tim.Illidge@ics.manchester.ac.uk [Institute of Cancer Sciences, University of Manchester, Manchester Academic Health Sciences Centre, The Christie National Health Service Foundation Trust, Manchester (United Kingdom); Specht, Lena [Department of Oncology and Hematology, Rigshospitalet, University of Copenhagen, Copenhagen (Denmark); Yahalom, Joachim [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Aleman, Berthe [Department of Radiotherapy, The Netherlands Cancer Institute, Amsterdam (Netherlands); Berthelsen, Anne Kiil [Department of Radiation Oncology and PET Centre, Rigshospitalet, University of Copenhagen, Copenhagen (Denmark); Constine, Louis [Departments of Radiation Oncology and Pediatrics, James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York (United States); Dabaja, Bouthaina [Division of Radiation Oncology, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Dharmarajan, Kavita [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Ng, Andrea [Department of Radiation Oncology, Brigham and Women' s Hospital and Dana-Farber Cancer Institute, Harvard University, Boston, Massachusetts (United States); Ricardi, Umberto [Radiation Oncology Unit, Department of Oncology, University of Torino, Torino (Italy); Wirth, Andrew [Division of Radiation Oncology, Peter MacCallum Cancer Institute, St. Andrews Place, East Melbourne (Australia)

2014-05-01

Radiation therapy (RT) is the most effective single modality for local control of non-Hodgkin lymphoma (NHL) and is an important component of therapy for many patients. Many of the historic concepts of dose and volume have recently been challenged by the advent of modern imaging and RT planning tools. The International Lymphoma Radiation Oncology Group (ILROG) has developed these guidelines after multinational meetings and analysis of available evidence. The guidelines represent an agreed consensus view of the ILROG steering committee on the use of RT in NHL in the modern era. The roles of reduced volume and reduced doses are addressed, integrating modern imaging with 3-dimensional planning and advanced techniques of RT delivery. In the modern era, in which combined-modality treatment with systemic therapy is appropriate, the previously applied extended-field and involved-field RT techniques that targeted nodal regions have now been replaced by limiting the RT to smaller volumes based solely on detectable nodal involvement at presentation. A new concept, involved-site RT, defines the clinical target volume. For indolent NHL, often treated with RT alone, larger fields should be considered. Newer treatment techniques, including intensity modulated RT, breath holding, image guided RT, and 4-dimensional imaging, should be implemented, and their use is expected to decrease significantly the risk for normal tissue damage while still achieving the primary goal of local tumor control.

Adventures in human population biology.

Science.gov (United States)

Baker, P T

1996-01-01

This article is a memoir of anthropologist Paul Baker's professional life. The introduction notes that the field of anthropology was altered by the impact of World War II when physical anthropologists provided vital information to the military. After the war, the GI bill supported the undergraduate and graduate studies of veterans, including Baker. After describing his academic training at the University of New Mexico and Harvard, Baker details his research training and field work in the desert for the US Climatic Research Laboratory and his work identifying the dead in Japan for the Quartermaster unit. Baker then traces his academic career at the Pennsylvania State University during which he directed two multidisciplinary research efforts for the International Biological Programme, one that sought to understand human adaptability at high altitude in Peru and another that studied migration and modernization in Samoa. Baker's last administrative positions were as staff consultant to the Man and the Biosphere (MAB) program and as chair of the US MAB committee. Baker retired from academic life at age 60 in 1987 and has devoted his time to reading and to helping organize professional associations in anthropology, especially those devoted to furthering internationally organized scientific efforts. Baker concludes this memoir by acknowledging the growth and development of the discipline of human population biology.

Radiobiology of Proton Therapy - Results of an international expert workshop

DEFF Research Database (Denmark)

Lühr, Armin; von Neubeck, Cläre; Pawelke, Jörg

2018-01-01

The physical properties of proton beams offer the potential to reduce toxicity in tumor-adjacent normal tissues. Toward this end, the number of proton radiotherapy facilities has steeply increased over the last 10-15 years to currently around 70 operational centers worldwide. However, taking full...... in proton therapy combined with systemic treatments, and (4) testing biological effects of protons in clinical trials. Finally, important research avenues for improvement of proton radiotherapy based on radiobiological knowledge are identified. The clinical distribution of radiobiological effectiveness...... of protons alone or in combination with systemic chemo- or immunotherapies as well as patient stratification based on biomarker expressions are key to reach the full potential of proton beam therapy. Dedicated preclinical experiments, innovative clinical trial designs, and large high-quality data...

Spa therapy in dermatology

Directory of Open Access Journals (Sweden)

Najeeba Riyaz

2011-01-01

Full Text Available Spa therapy constitutes the use of mineral springs and thermal mud to soothe and heal various ailments. Like the mineral springs, seas and oceans are also important centers for spa therapy of which the most important is Dead Sea (DS. DS has been famous for thousands of years for its miraculous curative and cosmetic properties. Intensive research is going on using DS minerals in a wide range of dermatological conditions especially psoriasis, atopic dermatitis, vitiligo and other eczemas and several papers have been published in various international and pharmacological journals.

Internal high linear energy transfer (LET) targeted radiotherapy for cancer

International Nuclear Information System (INIS)

Allen, Barry J

2006-01-01

High linear energy transfer (LET) radiation for internal targeted therapy has been a long time coming on to the medical therapy scene. While fundamental principles were established many decades ago, the clinical implementation has been slow. Localized neutron capture therapy, and more recently systemic targeted alpha therapy, are at the clinical trial stage. What are the attributes of these therapies that have led a band of scientists and clinicians to dedicate so much of their careers? High LET means high energy density, causing double strand breaks in DNA, and short-range radiation, sparing adjacent normal tissues. This targeted approach complements conventional radiotherapy and chemotherapy. Such therapies fail on several fronts. Foremost is the complete lack of progress for the control of primary GBM, the holy grail for cancer therapies. Next is the inability to regress metastatic cancer on a systemic basis. This has been the task of chemotherapy, but palliation is the major application. Finally, there is the inability to inhibit the development of lethal metastatic cancer after successful treatment of the primary cancer. This review charts, from an Australian perspective, the developing role of local and systemic high LET, internal radiation therapy. (review)

Efficacy of Second-line Targeted Therapy for Renal Cell Carcinoma According to Change from Baseline in International Metastatic Renal Cell Carcinoma Database Consortium Prognostic Category

DEFF Research Database (Denmark)

Davis, Ian D; Xie, Wanling; Pezaro, Carmel

2017-01-01

BACKGROUND: We hypothesized that changes in International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) prognostic category at start of second-line therapy (2L) for metastatic renal cell carcinoma (mRCC) might predict response. OBJECTIVE: To assess outcomes of 2L according to type...... of therapy and change in IMDC prognostic category. DESIGN, SETTING, AND PARTICIPANTS: We performed a retrospective review of the IMDC database for mRCC patients who received first-line (1L) VEGF inhibitors (VEGFi) and then 2L with VEGFi or mTOR inhibitors (mTORi). IMDC prognostic categories were defined......% confidence interval [CI] 12.0-19.0 for VEGFi; 20.2 mo, 95% CI 14.3-26.1 for mTORi; AHR 1.53, 95% CI 1.04-2.24; adjusted p=0.03). CONCLUSIONS: Changes in IMDC prognostic category predict the subsequent clinical course for patients with mRCC and provide a rational basis for selection of subsequent therapy...

Blood–brain barrier and laser technology for drug brain delivery

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Oxana V. Semyachkina-Glushkovskaya

2017-09-01

Photodynamic therapy (PDT is usual clinical method of surgical navigation for the resection of brain tumor and anti-cancer therapy. Nowadays, the application of PDT is considered as a potential promising tool for brain drug delivery via opening of BBB. Here, we show the first successful experimental results in this field discussing the adventures and disadvantages of PDT-related BBB disruption as well as alternatives to overcome these limitations and possible mechanisms with new pathways for brain clearance via glymphatic and lymphatic systems.

The Large Hadron Collider the greatest adventure in town and ten reasons why it matters, as illustrated by the ATLAS experiment

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Millington, Andrew J; MacPherson, Rob; Nordberg, Markus

2016-01-01

When the discovery of the Higgs Boson at CERN hit the headlines in 2012, the world was stunned by this achievement of modern science. Less well appreciated, however, were the many ways in which this benefited wider society. The Large Hadron Collider — The Greatest Adventure in Town charts a path through the cultural, economic and medical gains of modern particle physics. It illustrates these messages through the ATLAS experiment at CERN, one of the two big experiments which found the Higgs particle. Moving clear of in-depth physics analysis, it draws on the unparalleled curiosity about particle physics aroused by the Higgs discovery, and relates it to developments familiar in the modern world, including the Internet, its successor "The Grid", and the latest cancer treatments. In this book, advances made from developing the 27 kilometre particle accelerator and its detectors are presented with the benefit of first hand interviews and are extensively illustrated throughout. Interviewees are leading physicis...

Results of a Quality Assurance Review of External Beam Radiation Therapy in the International Society of Paediatric Oncology (Europe) Neuroblastoma Group's High-risk Neuroblastoma Trial: A SIOPEN Study

Energy Technology Data Exchange (ETDEWEB)

Gaze, Mark N., E-mail: mark.gaze@uclh.nhs.uk [Department of Oncology, University College London Hospitals NHS Foundation Trust, London (United Kingdom); Boterberg, Tom [Department of Radiation Oncology, Ghent University Hospital, Ghent (Belgium); Dieckmann, Karin; Hoermann, Marcus [General Hospital Vienna, Medical University Vienna (Austria); Gains, Jennifer E.; Sullivan, Kevin P. [Department of Oncology, University College London Hospitals NHS Foundation Trust, London (United Kingdom); Ladenstein, Ruth [Children' s Cancer Research Institute, St. Anna Children' s Hospital, Vienna (Austria)

2013-01-01

Purpose: Radiation therapy is important for local control in neuroblastoma. This study reviewed the compliance of plans with the radiation therapy guidelines of the International Society of Paediatric Oncology (Europe) Neuroblastoma Group (SIOPEN) High-Risk Trial protocol. Methods and Materials: The SIOPEN trial central electronic database has sections to record diagnostic imaging and radiation therapy planning data. Individual centers may upload data remotely, but not all centers involved in the trial chose to use this system. A quality scoring system was devised based on how well the radiation therapy plan matched the protocol guidelines, to what extent deviations were justified, and whether adverse effects may result. Central review of radiation therapy planning was undertaken retrospectively in 100 patients for whom complete diagnostic and treatment sets were available. Data were reviewed and compared against protocol guidelines by an international team of radiation oncologists and radiologists. For each patient in the sample, the central review team assigned a quality assurance score. Results: It was found that in 48% of patients there was full compliance with protocol requirements. In 29%, there were deviations for justifiable reasons with no likely long-term adverse effects resulting. In 5%, deviations had occurred for justifiable reasons, but that might result in adverse effects. In 1%, there was a deviation with no discernible justification, which would not lead to long-term adverse events. In 17%, unjustified deviations were noted, with a risk of an adverse outcome resulting. Conclusions: Owing to concern over the proportion of patients in whom unjustified deviations were observed, a protocol amendment has been issued. This offers the opportunity for central review of radiation therapy plans before the start of treatment and the treating clinician a chance to modify plans.

WORLD-WIDE PERSPECTIVES ON IMPROVISATIONAL MUSIC THERAPY FROM THE TIME-A PROJECT

DEFF Research Database (Denmark)

Gottfried, Tali; Thompson, Grace; Geretsegger, Monika

Background Improvisational music therapy methods have been viewed as a valuable way of working with children with autism spectrum disorder (ASD) since the pioneering efforts of Alvin and Nordoff and Robbins (Alvin, 1978; Nordoff & Robbins, 1977). The TIME-A project is a unique international...... collaboration targeted at investigating the effectiveness of improvisational music therapy (IMT) (Geretsegger, Holck, & Gold, 2012; Wigram, 2004) for children with autism spectrum disorder (ASD). Within this project, an international “consensus model” for IMT has been developed by drawing on the worldwide...... perspectives of the international collaborators. World Wide Perspectives on Improvisational Music Therapy with Children with Autism Spectrum Disorder Clinicians from 4 continents around the world presented examples of clinical work highlighting an aspect of working improvisationally in their local context...

Detection of Esophageal Fiducial Marker Displacement During Radiation Therapy With a 2-dimensional On-board Imager: Analysis of Internal Margin for Esophageal Cancer

International Nuclear Information System (INIS)

Fukada, Junichi; Hanada, Takashi; Kawaguchi, Osamu; Ohashi, Toshio; Takeuchi, Hiroya; Kitagawa, Yuko; Seki, Satoshi; Shiraishi, Yutaka; Ogata, Haruhiko; Shigematsu, Naoyuki

2013-01-01

Purpose: To quantify the interfraction displacement of esophageal fiducial markers for primary esophageal cancer radiation therapy. Methods and Materials: Orthogonal 2-dimensional (2D) matching records fused to vertebrae were analyzed in clinically staged T1/2N0 esophageal cancer patients undergoing endoscopic clipping as fiducial metal markers. Displacement of the markers between the digitally reconstructed radiographs and on-board kilovoltage images during radiation therapy was analyzed according to direction and esophageal site. Results: Forty-four patients, with 81 markers (10 proximal, 42 middle, and 29 distal), underwent 367 2D matching sessions during radiation therapy. The mean (SD) absolute marker displacement was 0.26 (0.30) cm in the right–left (RL), 0.50 (0.39) cm in the superior–inferior (SI), and 0.24 (0.21) cm in the anterior–posterior (AP) direction. Displacement was significantly larger in the SI than in the RL and AP directions (P<.0001). In the SI direction, mean absolute displacements of the distal, middle, and proximal esophagus were 0.67 (0.45) cm, 0.42 (0.32) cm, and 0.36 (0.30) cm, respectively. Distal esophagus displacement was significantly larger than those of the middle and proximal esophagus (P<.0001). The estimated internal margin to cover 95% of the cases was 0.75 cm in the RL and AP directions. In the SI direction, the margin was 1.25 cm for the proximal and middle esophagus and 1.75 cm for the distal esophagus. Conclusions: The magnitude of interfraction displacement of esophageal clips was larger in the SI direction, particularly in the distal esophagus, but substantial displacement was observed in other directions and at other esophageal sites. It is practical to take estimated movements into account with internal margins, even if vertebrae-based 2D matching is performed

Adventure sports and sexual freedom hip replacement: the tripolar hip.

Science.gov (United States)

Pritchett, James W

2018-01-01

Certain athletic activities and lifestyles require a completely stable and very mobile hip. Total hip replacement with a natural femoral head size and two mobile-bearing surfaces (i.e., a "tripolar" prosthesis) is the most stable prosthesis. Elegant design and wear-resistant bearing surfaces are the keys to long-term implant survivorship. The hypothesis is that a ceramic-coated tripolar prosthesis using highly cross-linked polyethylene can provide full function and complete stability with low wear. This study sought to determine: (1) patient-reported outcomes, (2) functional outcomes, (3) implant survivorship and complications, and (4) postoperative sexual limitations. Between 1998 and 2011, the author performed 160 primary total hip replacements using tripolar prostheses in patients participating in adventure sports and other physically demanding activities. The institutional review board approved this study. The inclusion criteria were patients who needed unrestricted activity and who were not candidates for or did not choose hip resurfacing. Patients were followed every second year and assessed with radiographs, Harris Hip Score, WOMAC, SF-12, and UCLA functional outcome scores. Patients were asked about symptoms of instability and satisfaction with their hip replacement. Patients were asked both preoperatively and 2 years postoperatively four questions about their sexual activity. Mean follow-up was 11 years. At 2 years' postoperatively, 98% of patients reported their satisfaction as excellent or good and 99% were not limited for sexual activity following surgery. Seventy-four percent of patients reported they were recovered within 6 weeks of surgery. There were no dislocations. There were three revision procedures for implant loosening, infection, and periprosthetic fracture, but there were no failures of the tripolar articulation. The mean postoperative UCLA score was the highly athletic score of 8. There were no signs of osteolysis, wear, or metal

Optimizing the use of intravenous therapy in internal medicine.

Science.gov (United States)

Champion, Karine; Mouly, Stéphane; Lloret-Linares, Celia; Lopes, Amanda; Vicaut, Eric; Bergmann, Jean-François

2013-10-01

We aimed to evaluate the impact of physicians' educational programs in the reduction of inappropriate intravenous lines in internal medicine. Fifty-six French internal medicine units were enrolled in a nationwide, prospective, blinded, randomized controlled trial. Forms describing the patients with an intravenous line and internal medicine department characteristics were filled out on 2 separate days in January and April 2007. Following the first visit, all units were randomly assigned to either a specific education program on the appropriate indications of an intravenous line, during February and March 2007, or no training (control group). The Investigators' Committee then blindly evaluated the clinical relevance of the intravenous line according to pre-established criteria. The primary outcome was the percentage of inappropriate intravenous lines. During January 2007, intravenous lines were used in 475 (24.9%) of the 1910 hospitalized patients. Of these, 80 (16.8%) were considered inappropriate. In April 2007, 416 (22.8%) of the 1823 hospitalized patients received an intravenous line, which was considered in 10.2% (21/205) of patients managed by trained physicians, versus 16.6% (35/211) of patients in the control group (relative difference 39%; 95% confidence interval, -0.6-13.3; P = .05). Reduced intravenous administration of fluids, antibiotics, and analgesics accounted for the observed decrease. The use of a simple education program reduced the rate of inappropriate intravenous lines by almost 40% in an internal medicine setting (NCT01633307). Copyright © 2013 Elsevier Inc. All rights reserved.

First on-line survey of an international multidisciplinary working group (MightyMedic) on current practice in diagnosis, therapy and follow-up of dyslipidemias.

Science.gov (United States)

Stefanutti, C; D'Alessandri, G; Petta, A; Harada-Shiba, M; Julius, U; Soran, H; Moriarty, P M; Romeo, S; Drogari, E; Jaeger, B R

2015-05-01

The MightyMedic (Multidisciplinary International Group for Hemapheresis TherapY and MEtabolic DIsturbances Contrast) Working Group has been founded in 2013. The leading idea was to establish an international network of interdisciplinary nature aimed at working to cross national borders research projects, clinical trials, educational initiatives (meetings, workshops, summer schools) in the field of metabolic diseases, namely hyperlipidemias, and diabetes, preventive cardiology, and atherosclerosis. Therapeutic apheresis, its indications and techniques, is a parallel field of investigation. The first on-line survey of the Group has been completed in the first half of 2014. The survey included # 24 Centers in Italy, Germany, Greece, UK, Sweden, Japan and USA. Relevant data have been collected on current practice in diagnosis, therapy and follow-up of dyslipidemias. 240 subjects with hyperlipidemia and treated with lipoprotein apheresis have been reported in the survey, but a large percentage of patients (35%) who could benefit from this therapeutic option are still treated by conventional drug approach. Genetic molecular diagnosis is performed in only 33% of patients while Lipoprotein(a) (Lp(a)) is included in cardiovascular disease risk assessment in 71% of participating Centers. New detailed investigations and prospective multicenter studies are needed to evaluate changes induced by the impact of updated indications and strategies, as well as new treatment options, targeting standardization of therapeutic and diagnostic approaches. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Music Therapy in Europe

DEFF Research Database (Denmark)

2015-01-01

Professional development and recognition is an 'old' issue in music therapy but still a relevant, complex and crucial one. Burning questions regarding professionalisation are at the forefront of most music therapy associations’ agendas across Europe and beyond, and feed back directly to the work...... of the EMTC. Considering the wider political, socio-economic, cultural and disciplinary aspects of professionalisation, different development pathways impact directly on music therapy practice, training, ethics, professional collaboration and employment conditions. Although a number of endeavours have been...... implemented regarding music therapy’s professional development and recognition in different countries, documentation and sharing of such endeavours on international level has been limited and scattered. Drawing from the EMTC’s work since the early ‘90s, as well as from colleagues’ experiences (and struggles...

Music therapy in palliative care: current perspectives.

Science.gov (United States)

O'Kelly, Julian

2002-03-01

As the music therapy profession has developed internationally over the last 25 years, so has its role in palliative care. Music is a highly versatile and dynamic therapeutic modality, lending itself to a variety of music therapy techniques used to benefit both those living with life-threatening illnesses and their family members and caregivers. This article will give a broad overview of the historical roots of music therapy and introduce the techniques that are employed in current practice. By combining a review of mainstream music therapy practice involving musical improvisation, song-writing and receptive/recreational techniques with case material from my own experience, this article aims to highlight the potential music therapy holds as an effective holistic practice for palliative care, whatever the care setting.

When does atopic dermatitis warrant systemic therapy?

DEFF Research Database (Denmark)

Simpson, Eric L; Bruin-Weller, Marjolein; Flohr, Carsten

2017-01-01

-specific literature review, referred to guidelines when available, and provided interpretation and expert opinion. RESULTS: We recommend a systematic and holistic approach to assess patients with severe signs and symptoms of AD and impact on quality of life before systemic therapy. Steps taken before commencing......BACKGROUND: Although most patients with atopic dermatitis (AD) are effectively managed with topical medication, a significant minority require systemic therapy. Guidelines for decision making about advancement to systemic therapy are lacking. OBJECTIVE: To guide those considering use of systemic...... therapy in AD and provide a framework for evaluation before making this therapeutic decision with the patient. METHODS: A subgroup of the International Eczema Council determined aspects to consider before prescribing systemic therapy. Topics were assigned to expert reviewers who performed a topic...

Modern Radiation Therapy for Hodgkin Lymphoma

DEFF Research Database (Denmark)

Specht, Lena; Yahalom, Joachim; Illidge, Tim

2014-01-01

Radiation therapy (RT) is the most effective single modality for local control of Hodgkin lymphoma (HL) and an important component of therapy for many patients. These guidelines have been developed to address the use of RT in HL in the modern era of combined modality treatment. The role of reduced...... on Radiation Units and Measurements concepts of gross tumor volume, clinical target volume, internal target volume, and planning target volume are used for defining the targeted volumes. Newer treatment techniques, including intensity modulated radiation therapy, breath-hold, image guided radiation therapy......, and 4-dimensional imaging, should be implemented when their use is expected to decrease significantly the risk for normal tissue damage while still achieving the primary goal of local tumor control. The highly conformal involved node radiation therapy (INRT), recently introduced for patients for whom...

Radiation Dose to the Esophagus From Breast Cancer Radiation Therapy, 1943-1996: An International Population-Based Study of 414 Patients

International Nuclear Information System (INIS)

Lamart, Stephanie; Stovall, Marilyn; Simon, Steven L.; Smith, Susan A.; Weathers, Rita E.; Howell, Rebecca M.; Curtis, Rochelle E.; Aleman, Berthe M.P.; Travis, Lois; Kwon, Deukwoo; Morton, Lindsay M.

2013-01-01

Purpose: To provide dosimetric data for an epidemiologic study on the risk of second primary esophageal cancer among breast cancer survivors, by reconstructing the radiation dose incidentally delivered to the esophagus of 414 women treated with radiation therapy for breast cancer during 1943-1996 in North America and Europe. Methods and Materials: We abstracted the radiation therapy treatment parameters from each patient’s radiation therapy record. Treatment fields included direct chest wall (37% of patients), medial and lateral tangentials (45%), supraclavicular (SCV, 64%), internal mammary (IM, 44%), SCV and IM together (16%), axillary (52%), and breast/chest wall boosts (7%). The beam types used were 60 Co (45% of fields), orthovoltage (33%), megavoltage photons (11%), and electrons (10%). The population median prescribed dose to the target volume ranged from 21 Gy to 40 Gy. We reconstructed the doses over the length of the esophagus using abstracted patient data, water phantom measurements, and a computational model of the human body. Results: Fields that treated the SCV and/or IM lymph nodes were used for 85% of the patients and delivered the highest doses within 3 regions of the esophagus: cervical (population median 38 Gy), upper thoracic (32 Gy), and middle thoracic (25 Gy). Other fields (direct chest wall, tangential, and axillary) contributed substantially lower doses (approximately 2 Gy). The cervical to middle thoracic esophagus received the highest dose because of its close proximity to the SCV and IM fields and less overlying tissue in that part of the chest. The location of the SCV field border relative to the midline was one of the most important determinants of the dose to the esophagus. Conclusions: Breast cancer patients in this study received relatively high incidental radiation therapy doses to the esophagus when the SCV and/or IM lymph nodes were treated, whereas direct chest wall, tangentials, and axillary fields contributed lower doses

Radiation dose to the esophagus from breast cancer radiation therapy, 1943-1996: an international population-based study of 414 patients.

Science.gov (United States)

Lamart, Stephanie; Stovall, Marilyn; Simon, Steven L; Smith, Susan A; Weathers, Rita E; Howell, Rebecca M; Curtis, Rochelle E; Aleman, Berthe M P; Travis, Lois; Kwon, Deukwoo; Morton, Lindsay M

2013-07-15

To provide dosimetric data for an epidemiologic study on the risk of second primary esophageal cancer among breast cancer survivors, by reconstructing the radiation dose incidentally delivered to the esophagus of 414 women treated with radiation therapy for breast cancer during 1943-1996 in North America and Europe. We abstracted the radiation therapy treatment parameters from each patient's radiation therapy record. Treatment fields included direct chest wall (37% of patients), medial and lateral tangentials (45%), supraclavicular (SCV, 64%), internal mammary (IM, 44%), SCV and IM together (16%), axillary (52%), and breast/chest wall boosts (7%). The beam types used were (60)Co (45% of fields), orthovoltage (33%), megavoltage photons (11%), and electrons (10%). The population median prescribed dose to the target volume ranged from 21 Gy to 40 Gy. We reconstructed the doses over the length of the esophagus using abstracted patient data, water phantom measurements, and a computational model of the human body. Fields that treated the SCV and/or IM lymph nodes were used for 85% of the patients and delivered the highest doses within 3 regions of the esophagus: cervical (population median 38 Gy), upper thoracic (32 Gy), and middle thoracic (25 Gy). Other fields (direct chest wall, tangential, and axillary) contributed substantially lower doses (approximately 2 Gy). The cervical to middle thoracic esophagus received the highest dose because of its close proximity to the SCV and IM fields and less overlying tissue in that part of the chest. The location of the SCV field border relative to the midline was one of the most important determinants of the dose to the esophagus. Breast cancer patients in this study received relatively high incidental radiation therapy doses to the esophagus when the SCV and/or IM lymph nodes were treated, whereas direct chest wall, tangentials, and axillary fields contributed lower doses. Published by Elsevier Inc.

Radiation Dose to the Esophagus From Breast Cancer Radiation Therapy, 1943-1996: An International Population-Based Study of 414 Patients

Energy Technology Data Exchange (ETDEWEB)

Lamart, Stephanie, E-mail: stephanie.lamart@nih.gov [Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States); Stovall, Marilyn [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Simon, Steven L. [Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States); Smith, Susan A.; Weathers, Rita E.; Howell, Rebecca M. [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Curtis, Rochelle E. [Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States); Aleman, Berthe M.P. [Department of Radiotherapy, The Netherlands Cancer Institute, Amsterdam (Netherlands); Travis, Lois [Rubin Center for Cancer Survivorship and Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York (United States); Kwon, Deukwoo [Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida (United States); Morton, Lindsay M. [Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States)

2013-07-15

Purpose: To provide dosimetric data for an epidemiologic study on the risk of second primary esophageal cancer among breast cancer survivors, by reconstructing the radiation dose incidentally delivered to the esophagus of 414 women treated with radiation therapy for breast cancer during 1943-1996 in North America and Europe. Methods and Materials: We abstracted the radiation therapy treatment parameters from each patient’s radiation therapy record. Treatment fields included direct chest wall (37% of patients), medial and lateral tangentials (45%), supraclavicular (SCV, 64%), internal mammary (IM, 44%), SCV and IM together (16%), axillary (52%), and breast/chest wall boosts (7%). The beam types used were {sup 60}Co (45% of fields), orthovoltage (33%), megavoltage photons (11%), and electrons (10%). The population median prescribed dose to the target volume ranged from 21 Gy to 40 Gy. We reconstructed the doses over the length of the esophagus using abstracted patient data, water phantom measurements, and a computational model of the human body. Results: Fields that treated the SCV and/or IM lymph nodes were used for 85% of the patients and delivered the highest doses within 3 regions of the esophagus: cervical (population median 38 Gy), upper thoracic (32 Gy), and middle thoracic (25 Gy). Other fields (direct chest wall, tangential, and axillary) contributed substantially lower doses (approximately 2 Gy). The cervical to middle thoracic esophagus received the highest dose because of its close proximity to the SCV and IM fields and less overlying tissue in that part of the chest. The location of the SCV field border relative to the midline was one of the most important determinants of the dose to the esophagus. Conclusions: Breast cancer patients in this study received relatively high incidental radiation therapy doses to the esophagus when the SCV and/or IM lymph nodes were treated, whereas direct chest wall, tangentials, and axillary fields contributed lower

Translation and adaptation procedures for music therapy outcome instruments

DEFF Research Database (Denmark)

Ridder, Hanne Mette Ochsner; McDermott, Orii; Orrell, Martin

2017-01-01

With increasing occurrence of international multicentre studies, there is a need for music therapy outcome measures to become more widely available across countries. For countries where English is not the first language, translation and cross-cultural adaptation of outcome measures may be necessa...... procedural steps for the translation and adaptation of music therapy outcome instruments. OBS: 50 free online copies to share: http://www.tandfonline.com/eprint/d8TPZbkVMjzgKg7DjcmT/full......With increasing occurrence of international multicentre studies, there is a need for music therapy outcome measures to become more widely available across countries. For countries where English is not the first language, translation and cross-cultural adaptation of outcome measures may be necessary....... A literature review identified a knowledge gap regarding translation procedures of outcome measures used in music therapy research. However, a large body of translation guidelines is available in other health professions. We used the guidelines from these related fields to identify guidelines and outline...

Client Motivation for Therapy Scale: a measure of intrinsic motivation, extrinsic motivation, and amotivation for therapy.

Science.gov (United States)

Pelletier, L G; Tuson, K M; Haddad, N K

1997-04-01

The purpose of this study was to examine the psychometric properties of a new measure of client motivation for therapy, the Client Motivation for Therapy Scale. This scale is designed to measure client's Intrinsic Motivation, four forms of regulation for Extrinsic Motivation (integrated, identified, introjected, and external regulation), and Amotivation for therapy. These subscales correspond to different forms of motivation identified by Deci and Ryan (1985) and fall along a self-determination continuum. An experimental version of the scale, along with related scales, was distributed to a total sample of 138 clients involved in therapy. The results supported the factor structure of the scale and revealed a satisfactory level of internal consistency. Correlations among the subscales revealed a simplex pattern that, in general, provides support for the self-determination continuum and the construct validity of the scale. Implications for research on client motivation for therapy are discussed.

Roads to Learning: Adventures in Education.

Science.gov (United States)

Eyster, John W.; Griffin, Michael C.

The booklet describes a social studies field study seminar which utilizes a direct experiential approach to increase high school student comprehension of federal and international politics. The first chapter explains the objectives of the seminars; the second and third chapters discuss the two major seminars which build upon previously taught…

[Decorporation agents for internal radioactive contamination].

Science.gov (United States)

Ohmachi, Yasushi

2015-01-01

When radionuclides are accidentally ingested or inhaled, blood circulation or tissue/organ deposition of the radionuclides causes systemic or local radiation effects. In such cases, decorporation therapy is used to reduce the health risks due to their intake. Decorporation therapy includes reduction and/or inhibition of absorption from the gastrointestinal tract, isotopic dilution, and the use of diuretics, adsorbents, and chelating agents. For example, penicillamine is recommended as a chelating agent for copper contamination, and diethylene triamine pentaacetic acid is approved for the treatment of internal contamination with plutonium. During chelation therapy, the removal effect of the drugs should be monitored using a whole-body counter and/or bioassay. Some authorities, such as the National Council on Radiation Protection and Measurements and International Atomic Energy Agency, have reported recommended decorporation agents for each radionuclide. However, few drugs are approved by the US Food and Drug Administration, and many are off-label-use agents. Because many decontamination agents are drugs that have been available for a long time and have limited efficacy, the development of new, higher-efficacy drugs has been carried out mainly in the USA and France. In this article, in addition to an outline of decorporation agents for internal radioactive contamination, an outline of our research on decorporation agents for actinide (uranium and plutonium) contamination and for radio-cesium contamination is also presented.

Internal dosimetry for the radiological protection of the patient in the therapy with I-131; Dosimetria interna para la proteccion radiologica del paciente en la terapia con I-131

Energy Technology Data Exchange (ETDEWEB)

Deluca, G.M.; Rojo, A.M. [Autoridad Regulatoria Nuclear, Av. Del Libertador 8250 (C1429BNP), Buenos Aires (Argentina)]. e-mail: gdeluca@cae.arn.gov.ar

2006-07-01

In the patients with differentiated thyroid cancer (CADIT) subjected to therapy with radiopharmaceuticals should be considered the possible risk of sharp depression of the bone marrow like consequence of the intolerance to the quantity of administered activity. The manifestation of the myelotoxicity can limit in a substantial way the future treatments and to deteriorate the predict of resolution of the illness. In this work it shows the physical-mathematical mark of a methodology for the estimated absorbed dose in bone marrow based in the MIRD scheme whose objective is to protect the one patient of the noxious and undesirable effects of the internal radiotherapy in organs that are not target of the same one. The formalism incorporates specific information of the patient and also peculiar characteristics of the internal therapy in patient with CADIT. The considerations are the following ones: (1) the main organ to protect is the bone marrow: (2) the accumulated activity, in bone marrow, it is obtained starting from measurements in blood: (3) the used isotope almost exclusively in this type of therapies is the {sup 131}I; (4) it is used as radiopharmaceutical at the {sup 131}INa that it is characterized to be a simple, inorganic and small molecule: (5) the statistical incidence of the CADIT is bigger in women than in men. It is explained for that it was selected the formalism that is presented, the principles on which it is sustained which are their reaches and their limitations. They are also presented future innovations that can be implemented to effects of improving the estimates. The work is framed inside the thematic of the medical applications of open radioactive sources and it constitutes a contribution to the invigoration of the internal therapy with radiopharmaceuticals. This is due to that the methodology of dose estimation presented supplements with a theoretical biophysics base the protocols of empiric prescription broadly used in this practice. For these

Quality assurance study for dosimetry of Radiation Therapy equipment in Saudi Arabia

International Nuclear Information System (INIS)

Al-Mokhlef, Jazi M.; Nabaz, Noori

2003-01-01

International standards address the accuracy of dose delivery for radiation therapy machines as well as quality assurance and staffing levels for radiation therapy centers. We performed absolute calibrations of gamma ,X-ray and electron radiotherapy beams in all radiation therapy centers in Saudi Arabia. We also assessed quality assurance and staffing levels Dosimetric measurements were made with a portable dosimetry system, which consisted of a calibrated Farmer ionization chamber and an electrometer, small water phantom, barometer and thermometer. Differences between the measured and the expected output (c Gy/MU or c Gy/min) were found to be in the range of -11%+5%. About 17% of radiotherapy beams were not within the acceptable tolerance level (+/-3%). Quality assurance in some radiation centers was poor and staffing levels were inadequate. We found poor compliance with internationally accepted tolerance levels for dose calibration of radiotherapy beams at radiation therapy centers in Saudi Arabia. Analysis of medical physics staffing revealed severe discrepancies from those recommended by international guidelines .We recommend that radiation therapy centers be adequately staffed with qualified medical physics personnel and that periodic audit programs be required a governmental body. (author)

Radiation Therapy for Primary Cutaneous Anaplastic Large Cell Lymphoma: An International Lymphoma Radiation Oncology Group Multi-institutional Experience

Energy Technology Data Exchange (ETDEWEB)

Million, Lynn, E-mail: lmillion@stanford.edu [Stanford Cancer Institute, Stanford, California (United States); Yi, Esther J.; Wu, Frank; Von Eyben, Rie [Stanford Cancer Institute, Stanford, California (United States); Campbell, Belinda A. [Department of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, East Melbourne (Australia); Dabaja, Bouthaina [The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Tsang, Richard W. [Department of Radiation Oncology, Princess Margaret Cancer Centre, Toronto, Ontario (Canada); Ng, Andrea [Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts (United States); Wilson, Lynn D. [Department of Therapeutic Radiology/Radiation Oncology, Yale School of Medicine, Yale Cancer Center, New Haven, Connecticut (United States); Ricardi, Umberto [Department of Oncology, University of Turin, Turin (Italy); Kirova, Youlia [Institut Curie, Paris (France); Hoppe, Richard T. [Stanford Cancer Institute, Stanford, California (United States)

2016-08-01

Purpose: To collect response rates of primary cutaneous anaplastic large cell lymphoma, a rare cutaneous T-cell lymphoma, to radiation therapy (RT), and to determine potential prognostic factors predictive of outcome. Methods and Materials: The study was a retrospective analysis of patients with primary cutaneous anaplastic large cell lymphoma who received RT as primary therapy or after surgical excision. Data collected include initial stage of disease, RT modality (electron/photon), total dose, fractionation, response to treatment, and local recurrence. Radiation therapy was delivered at 8 participating International Lymphoma Radiation Oncology Group institutions worldwide. Results: Fifty-six patients met the eligibility criteria, and 63 tumors were treated: head and neck (27%), trunk (14%), upper extremities (27%), and lower extremities (32%). Median tumor size was 2.25 cm (range, 0.6-12 cm). T classification included T1, 40 patients (71%); T2, 12 patients (21%); and T3, 4 patients (7%). The median radiation dose was 35 Gy (range, 6-45 Gy). Complete clinical response (CCR) was achieved in 60 of 63 tumors (95%) and partial response in 3 tumors (5%). After CCR, 1 tumor recurred locally (1.7%) after 36 Gy and 7 months after RT. This was the only patient to die of disease. Conclusions: Primary cutaneous anaplastic large cell lymphoma is a rare, indolent cutaneous lymphoma with a low death rate. This analysis, which was restricted to patients selected for treatment with radiation, indicates that achieving CCR was independent of radiation dose. Because there were too few failures (<2%) for statistical analysis on dose response, 30 Gy seems to be adequate for local control, and even lower doses may suffice.

Proceedings of the International Conference on New Interfaces for Musical Expression

OpenAIRE

Jensenius, Alexander Refsum; Skogstad, Ståle Andreas van Dorp; Nymoen, Kristian

2011-01-01

Editors: Alexander Refsum Jensenius, Anders Tveit, Rolf Inge Godøy, Dan Overholt Table of Contents -Tellef Kvifte: Keynote Lecture 1: Musical Instrument User Interfaces: the Digital Background of the Analog Revolution - page 1 -David Rokeby: Keynote Lecture 2: Adventures in Phy-gital Space - page 2 -Sergi Jordà: Keynote Lecture 3: Digital Lutherie and Multithreaded Musical Performance: Artistic, Scientific and Commercial Perspectives - page 3 Paper session A — Monday 30 May ...

Occupational Therapy and Primary Care: Updates and Trends

Science.gov (United States)

Mroz, Tracy M.; Fogelberg, Donald J.; Leland, Natalie E.

2018-01-01

As our health care system continues to change, so do the opportunities for occupational therapy. This article provides an update to a 2012 Health Policy Perspectives on this topic. We identify new initiatives and opportunities in primary care, explore common challenges to integrating occupational therapy in primary care environments, and highlight international works that can support our efforts. We conclude by discussing next steps for occupational therapy practitioners in order to continue to progress our efforts in primary care. PMID:29689169

Acidity-Triggered Tumor Retention/Internalization of Chimeric Peptide for Enhanced Photodynamic Therapy and Real-Time Monitoring of Therapeutic Effects.

Science.gov (United States)

Han, Kai; Zhang, Wei-Yun; Ma, Zhao-Yu; Wang, Shi-Bo; Xu, Lu-Ming; Liu, Jia; Zhang, Xian-Zheng; Han, He-You

2017-05-17

Photodynamic therapy (PDT) holds great promise in tumor treatment. Nevertheless, it remains highly desirable to develop easy-to-fabricated PDT systems with improved tumor accumulation/internalization and timely therapeutic feedback. Here, we report a tumor-acidity-responsive chimeric peptide for enhanced PDT and noninvasive real-time apoptosis imaging. Both in vitro and in vivo studies revealed that a tumor mildly acidic microenvironment could trigger rapid protonation of carboxylate anions in chimeric peptide, which led to increased ζ potential, improved hydrophobicity, controlled size enlargement, and precise morphology switching from sphere to spherocylinder shape of the chimeric peptide. All of these factors realized superfast accumulation and prolonged retention in the tumor region, selective cellular internalization, and enhanced PDT against the tumor. Meanwhile, this chimeric peptide could further generate reactive oxygen species and initiate cell apoptosis during PDT. The subsequent formation of caspase-3 enzyme hydrolyzed the chimeric peptide, achieving a high signal/noise ratio and timely fluorescence feedback. Importantly, direct utilization of the acidity responsiveness of a biofunctional Asp-Glu-Val-Asp-Gly (DEVDG, caspase-3 enzyme substrate) peptide sequence dramatically simplified the preparation and increased the performance of the chimeric peptide furthest.

Arte pixelado, nostalgia y géneros perdidos: “Resonance” o el resurgir de la aventura gráfica clásica = Pixel art, nostalgia and lost types: “Resonance” or the reemerge of a classic graphic adventure

Directory of Open Access Journals (Sweden)

Antonio José Planells de la Maza

2013-12-01

Full Text Available Resumen Las aventuras gráficas, antaño uno de los géneros más relevantes de la industria del videojuego, parecen ya no tener cabida en una época de grandes presupuestos y tecnología puntera. Los juegos de acción, el rol online y las propuestas multijugador han desplazado un tipo de juego más centrado en el descubrimiento narrativo, los diálogos y el juego individual. No obstante, el reciente éxito de propuestas como The Walking Dead ha colocado el género, otra vez, en el centro de atención. En este contexto y lejos de la industria masiva del ocio electrónico emerge Resonance, una aventura retro de baja producción que ha conseguido recuperar el gusto por el arte pixelado en los videojuegos y ha establecido nuevas coordenadas sobre la nostalgia y la mitificación de los géneros caídos. En esta investigación se analiza el uso de los componentes estéticos y el diseño del mundo ludoficcional para reivindicar, una vez más, el drama simbólico construido desde la aventura gráfica tradicional. Abstract Graphic adventure games, once one of the most important genres of the video game industry, seem to have no place in an era of big budgets and cuttingedge technology. Action games, online RPG products and multiplayer games have taken the place of a type of game more focused on narrative, dialogues and individual play. However, the recent success of the game The Walking Dead placed again this game genre in the spotlight. In this context and quite far away from the massive electronic entertainment industry emerges Resonance, a low production retro adventure that has brought the taste for video games pixel art and has set new coordinates on nostalgia and the myth of the fallen genre. This research examines the use of aesthetic components and ludofictional design world to claim, once again, the symbolic drama built from traditional graphic adventures.

Circumvention of resistance to photodynamic therapy in doxorubicin-resistant sarcoma by photochemical internalization of gelonin.

Science.gov (United States)

Olsen, Cathrine Elisabeth; Berg, Kristian; Selbo, Pål Kristian; Weyergang, Anette

2013-12-01

A wide range of anti-cancer therapies have been shown to induce resistance upon repetitive treatment and such adapted resistance may also cause cross-resistance to other treatment modalities. We here show that MES-SA/Dx5 cells with adapted resistance to doxorubicin (DOX) are cross-resistant to photodynamic therapy (PDT). A DOX-induced increased expression of the reactive oxygen species (ROS)-scavenging proteins glutathione peroxidase (GPx) 1 and GPx4 in MES-SA/Dx5 cells was indicated as the mechanism of resistance to PDT in line with the reduction in PDT-generated ROS observed in this cell line. ROS-induced p38 activation was, in addition, shown to be reduced to one-third of the signal of the parental MES-SA cells 2h after PDT, and addition of the p38 inhibitor SB203580 confirmed p38 activation as a death signal after PDT in the MES-SA cells. The MES-SA/Dx5 cells were also cross-resistant to ionizing radiation in agreement with the increased GPx1 and GPx4 expression. Surprisingly, PDT-induced endo/lysosomal release of the ribosome-inactivating protein gelonin (photochemical internalization (PCI)) was more effective in the PDT-resistant MES-SA/Dx5 cells, as measured by synergy calculations in both cell lines. Analysis of death-inducing signaling indicated a low activation of caspase-3 and a strong PARP I cleavage after PDT and PCI in both cell lines. The PARP I activation was, however, stronger after PCI than after PDT in the MES-SA cells, but not in the MES-SA/Dx5 cells, and therefore cannot explain the strong PCI effect in the MES-SA/Dx5 cells. In conclusion PCI of recombinant gelonin circumvents ROS resistance in an apoptosis-independent manner. © 2013 Elsevier Inc. All rights reserved.

Viewers' perceptions of a YouTube music therapy session video.

Science.gov (United States)

Gregory, Dianne; Gooding, Lori G

2013-01-01

Recent research revealed diverse content and varying levels of quality in YouTube music therapy videos and prompted questions about viewers' discrimination abilities. This study compares ratings of a YouTube music therapy session video by viewers with different levels of music therapy expertise to determine video elements related to perceptions of representational quality. Eighty-one participants included 25 novices (freshmen and sophomores in an introductory music therapy course), 25 pre-interns (seniors and equivalency students who had completed all core Music Therapy courses), 26 professionals (MT-BC or MT-BC eligibility) with a mean of 1.75 years of experience, and an expert panel of 5 MT-BC professionals with a mean of 11 years of experience in special education. After viewing a music therapy special education video that in previous research met basic competency criteria and professional standards of the American Music Therapy Association, participants completed a 16-item questionnaire. Novices' ratings were more positive (less discriminating) compared to experienced viewers' neutral or negative ratings. Statistical analysis (ANOVA) of novice, pre-intern, and professional ratings of all items revealed significant differences p, .05) for specific therapy content and for a global rating of representational quality. Experienced viewers' ratings were similar to the expert panel's ratings. Content analysis of viewers' reasons for their representational quality ratings corroborated ratings of therapy-specific content. A video that combines and clearly depicts therapy objectives, client improvement, and the effectiveness of music within a therapeutic intervention best represent the music therapy profession in a public social platform like YouTube.

Modern radiation therapy for extranodal lymphomas

DEFF Research Database (Denmark)

Yahalom, Joachim; Illidge, Tim; Specht, Lena

2015-01-01

Extranodal lymphomas (ENLs) comprise about a third of all non-Hodgkin lymphomas (NHL). Radiation therapy (RT) is frequently used as either primary therapy (particularly for indolent ENL), consolidation after systemic therapy, salvage treatment, or palliation. The wide range of presentations of ENL...... and treatment planning for the most frequently involved organs. Specifically, detailed recommendations for RT volumes are provided. We have applied the same modern principles of involved site radiation therapy as previously developed and published as guidelines for Hodgkin lymphoma and nodal NHL. We have...... there is a lack of guidelines for the use of RT in the management of ENL. This report presents an effort by the International Lymphoma Radiation Oncology Group (ILROG) to harmonize and standardize the principles of treatment of ENL, and to address the technical challenges of simulation, volume definition...

Thrombosis of internal carotid artery following blunt neck injuries

International Nuclear Information System (INIS)

Houdek, M.; Klaus, E.

1986-01-01

Complicated problems of nonpenetrating injuries of the internal carotid artery, their pathophysiological mechanisms, clinical picture, diagnosis and therapy are analyzed. The possible surgical management is considered. Attention was paid to angiographic diagnosis of traumatic and spontaneous lesions of internal carotid arteries. (author). 87 refs

Mechanisms for the Negative Effects of Internalized HIV-Related Stigma on Antiretroviral Therapy Adherence in Women: The Mediating Roles of Social Isolation and Depression.

Science.gov (United States)

Turan, Bulent; Smith, Whitney; Cohen, Mardge H; Wilson, Tracey E; Adimora, Adaora A; Merenstein, Daniel; Adedimeji, Adebola; Wentz, Eryka L; Foster, Antonina G; Metsch, Lisa; Tien, Phyllis C; Weiser, Sheri D; Turan, Janet M

2016-06-01

Internalization of HIV-related stigma may inhibit a person's ability to manage HIV disease through adherence to treatment regimens. Studies, mainly with white men, have suggested an association between internalized stigma and suboptimal adherence to antiretroviral therapy (ART). However, there is a scarcity of research with women of different racial/ethnic backgrounds and on mediating mechanisms in the association between internalized stigma and ART adherence. The Women's Interagency HIV Study (WIHS) is a multicenter cohort study. Women living with HIV complete interviewer-administered questionnaires semiannually. Cross-sectional analyses for the current article included 1168 women on ART for whom data on medication adherence were available from their last study visit between April 2013 and March 2014, when the internalized stigma measure was initially introduced. The association between internalized stigma and self-reported suboptimal ART adherence was significant for those in racial/ethnic minority groups (AOR = 0.69, P = 0.009, 95% CI: 0.52 to 0.91), but not for non-Hispanic whites (AOR = 2.15, P = 0.19, 95% CI: 0.69 to 6.73). Depressive symptoms, loneliness, and low perceived social support mediated the association between internalized stigma and suboptimal adherence in the whole sample, as well as in the subsample of minority participants. In serial mediation models, internalized stigma predicted less-perceived social support (or higher loneliness), which in turn predicted more depressive symptoms, which in turn predicted suboptimal medication adherence. Findings suggest that interconnected psychosocial mechanisms affect ART adherence, and that improvements in adherence may require multifaceted interventions addressing both mental health and interpersonal factors, especially for minority women.

Density overwrites of internal tumor volumes in intensity modulated proton therapy plans for mobile lung tumors

Science.gov (United States)

Botas, Pablo; Grassberger, Clemens; Sharp, Gregory; Paganetti, Harald

2018-02-01

The purpose of this study was to investigate internal tumor volume density overwrite strategies to minimize intensity modulated proton therapy (IMPT) plan degradation of mobile lung tumors. Four planning paradigms were compared for nine lung cancer patients. Internal gross tumor volume (IGTV) and internal clinical target volume (ICTV) structures were defined encompassing their respective volumes in every 4DCT phase. The paradigms use different planning CT (pCT) created from the average intensity projection (AIP) of the 4DCT, overwriting the density within the IGTV to account for movement. The density overwrites were: (a) constant filling with 100 HU (C100) or (b) 50 HU (C50), (c) maximum intensity projection (MIP) across phases, and (d) water equivalent path length (WEPL) consideration from beam’s-eye-view. Plans were created optimizing dose-influence matrices calculated with fast GPU Monte Carlo (MC) simulations in each pCT. Plans were evaluated with MC on the 4DCTs using a model of the beam delivery time structure. Dose accumulation was performed using deformable image registration. Interplay effect was addressed applying 10 times rescanning. Significantly less DVH metrics degradation occurred when using MIP and WEPL approaches. Target coverage (D99≥slant 70 Gy(RBE)) was fulfilled in most cases with MIP and WEPL (D{{99}WEPL}=69.2+/- 4.0 Gy (RBE)), keeping dose heterogeneity low (D5-D{{95}WEPL}=3.9+/- 2.0 Gy(RBE)). The mean lung dose was kept lowest by the WEPL strategy, as well as the maximum dose to organs at risk (OARs). The impact on dose levels in the heart, spinal cord and esophagus were patient specific. Overall, the WEPL strategy gives the best performance and should be preferred when using a 3D static geometry for lung cancer IMPT treatment planning. Newly available fast MC methods make it possible to handle long simulations based on 4D data sets to perform studies with high accuracy and efficiency, even prior to individual treatment planning.

International multicentre randomised controlled trial of improvisational music therapy for children with autism spectrum disorder: TIME-A study.

Science.gov (United States)

Crawford, Mike J; Gold, Christian; Odell-Miller, Helen; Thana, Lavanya; Faber, Sarah; Assmus, Jörg; Bieleninik, Łucja; Geretsegger, Monika; Grant, Claire; Maratos, Anna; Sandford, Stephan; Claringbold, Amy; McConachie, Helen; Maskey, Morag; Mössler, Karin Antonia; Ramchandani, Paul; Hassiotis, Angela

2017-10-01

Preliminary studies have indicated that music therapy may benefit children with autism spectrum disorders (ASD). To examine the effects of improvisational music therapy (IMT) on social affect and responsiveness of children with ASD. International, multicentre, three-arm, single-masked randomised controlled trial, including a National Institute for Health Research (NIHR)-funded centre that recruited in London and the east of England. Randomisation was via a remote service using permuted blocks, stratified by study site. Schools and private, voluntary and state-funded health-care services. Children aged between 4 and 7 years with a confirmed diagnosis of ASD and a parent or guardian who provided written informed consent. We excluded children with serious sensory disorder and those who had received music therapy within the past 12 months. All parents and children received enhanced standard care (ESC), which involved three 60-minute sessions of advice and support in addition to treatment as usual. In addition, they were randomised to either one (low-frequency) or three (high-frequency) sessions of IMT per week, or to ESC alone, over 5 months in a ratio of 1 : 1 : 2. The primary outcome was measured using the social affect score derived from the Autism Diagnostic Observation Schedule (ADOS) at 5 months: higher scores indicated greater impairment. Secondary outcomes included social affect at 12 months and parent-rated social responsiveness at 5 and 12 months (higher scores indicated greater impairment). A total of 364 participants were randomised between 2011 and 2015. A total of 182 children were allocated to IMT (90 to high-frequency sessions and 92 to low-frequency sessions), and 182 were allocated to ESC alone. A total of 314 (86.3%) of the total sample were followed up at 5 months [165 (90.7%) in the intervention group and 149 (81.9%) in the control group]. Among those randomised to IMT, 171 (94.0%) received it. From baseline to 5 months, mean scores of ADOS

Time to reconsider nonsurgical therapy of benign nontoxic multinodular goitre. Focus on recombinant human TSH (rhTSH) augmented radioiodine therapy

DEFF Research Database (Denmark)

Fast, Søren; Nielsen, Viveque; Bonnema, Steen

2009-01-01

alternatives are needed. Until recently, levothyroxine therapy was the preferred non-surgical alternative, but due to low efficacy and potential side-effects, it is not recommended for routine use in recent international guidelines. Conventional radioiodine (131I)-therapy has been used for two decades......, which makes 131I-therapy less feasible. Another challenge is the negative correlation between initial goitre size and goitre volume reduction (GVR). With its ability to more than double the thyroid 131I-uptake, recombinant human TSH (rhTSH) increases the absorbed radiation dose and thus enhances the GVR...... efficacy. Thus, although in its infancy, and still experimental, rhTSH-augmented 131I-therapy may profoundly alter the nonsurgical treatment of benign non-toxic MNG....

In my own words: the translation of reporting verbs on the parallel corpus the adventures of Huckleberry Finn — As aventuras de Huck

Directory of Open Access Journals (Sweden)

Daniel Alves

2016-01-01

Full Text Available This article examines Monteiro Lobato’s (retextualization of Mark Twain’s The Adventures of Huckleberry Finn. The analysis focuses on reporting verbs in instances of direct speech. The methodology used for data collection is based on Corpus Linguistics and the analysis built on the hallidayan systemic-functional grammar. The aim of this paper is to explore patterns in the choice of reporting verbs in Twain’s and Lobato’s textualizations particularly in connection with neutral verbs, such as ‘say’ in English and ‘dizer’ in Portuguese. Results show that Lobato’s (retextualization tends to select Free Direct Discourse, (instead of Direct Discourse and a wider variety of reporting verbs, there being no single verb accounting for more than 25% of all occurrences of direct discourse examined. The neutral verb ‘say’ was also observed to have been (retextualized by reporting verbs that signal speech function, indicating either information giving or demanding, and by verbs that realize an additional feature or specify speech connotation.

Review of the 25th annual scientific meeting of the International Society for Biological Therapy of Cancer.

Science.gov (United States)

Balwit, James M; Kalinski, Pawel; Sondak, Vernon K; Coulie, Pierre G; Jaffee, Elizabeth M; Gajewski, Thomas F; Marincola, Francesco M

2011-05-12

Led by key opinion leaders in the field, the 25th Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc, recently renamed the Society for Immunotherapy of Cancer, SITC) provided a scientific platform for ~500 attendees to exchange cutting-edge information on basic, clinical, and translational research in cancer immunology and immunotherapy. The meeting included keynote addresses on checkpoint blockade in cancer therapy and recent advances in therapeutic vaccination against cancer induced by Human Papilloma Virus 16. Participants from 29 countries interacted through oral presentations, panel discussions, and posters on topics that included dendritic cells and cancer, targeted therapeutics and immunotherapy, innate/adaptive immune interplay in cancer, clinical trial endpoints, vaccine combinations, countering negative regulation, immune cell trafficking to tumor microenvironment, and adoptive T cell transfer. In addition to the 50 oral presentations and >180 posters on these topics, a new SITC/iSBTc initiative to create evidence-based Cancer Immunotherapy Guidelines was announced. The SITC/iSBTc Biomarkers Taskforce announced the release of recommendations on immunotherapy biomarkers and a highly successful symposium on Immuno-Oncology Biomarkers that took place on the campus of the National Institutes of Health (NIH) immediately prior to the Annual Meeting. At the Annual Meeting, the NIH took the opportunity to publicly announce the award of the U01 grant that will fund the Cancer Immunotherapy Trials Network (CITN). In summary, the Annual Meeting gathered clinicians and scientists from academia, industry, and regulatory agencies from around the globe to interact and exchange important scientific advances related to tumor immunobiology and cancer immunotherapy.

A clinical treatment intervention for dysphoria: externalizing metaphors therapy.

Science.gov (United States)

McGuinty, Everett; Armstrong, David; Carrière, Anne-Marie

2014-01-01

The purpose of this article is to explore a novel, short-term treatment intervention for internalizing behaviours. This intervention is primarily based upon an externalizing process, transforming of metaphoric imagery, and shifting of underlying maladaptive emotional schemas. This article addresses the clinical population of children and youth, specifically through outlining the protocol, externalizing metaphors therapy. A selective review of significant works regarding the efficacy of short-term therapy was conducted, including the process of change within narrative therapy. It is proposed that two specific processes account for the mental health change experienced by clients who receive this new treatment intervention: (1) externalization of problems and (2) purposeful client-generated metaphor manipulation, impacting upon underlying schemas. From these theoretical constructs, the present article outlines a three-session treatment protocol that manualizes these key clinical processes. A case study is presented to illustrate this intervention for anxiety and depression. Further clinical research is underway to address the testable hypotheses resulting from the current theoretical model. Clinical trials in brief psychotherapy are suggested to empirically evaluate the efficacy of this new treatment intervention for dysphoria. This article outlines a short-term treatment intervention for anxiety and depression (dysphoira) through a novel 3-session model, where the clinician-practitioner can obtain competency through a one-day workshop.Its relevance for the clinical researcher and the mental health community is in its versatility in addressing internalizing behavior for four clinical populations: (1) children and adolescents; (2) children and adolescents on the autism spectrum; (3) adults in general; and, (4) adults with a dual-diagnosis. The treatment protocol described within is based upon the externalizing and deconstructive properties of Narrative Therapy, and the

Proceedings of the first international symposium on neutron capture therapy

Energy Technology Data Exchange (ETDEWEB)

Fairchild, R.G.; Brownell, G.L. (eds.)

1982-01-01

This meeting was arranged jointly by MIT and BNL in order to illuminate progress in the synthesis and targeting of boron compounds and to evaluate and document progress in radiobiological and dosimetric aspects of neutron capture therapy. It is hoped that this meeting will facilitate transfer of information between groups working in these fields, and encourage synergistic collaboration.

Proceedings of the first international symposium on neutron capture therapy

International Nuclear Information System (INIS)

Fairchild, R.G.; Brownell, G.L.

1982-01-01

This meeting was arranged jointly by MIT and BNL in order to illuminate progress in the synthesis and targeting of boron compounds and to evaluate and document progress in radiobiological and dosimetric aspects of neutron capture therapy. It is hoped that this meeting will facilitate transfer of information between groups working in these fields, and encourage synergistic collaboration

Art Therapy and Dissociative Disorders.

Science.gov (United States)

Engle, Patricia

1997-01-01

Demonstrates how art therapy helped a woman address her identity and memory difficulties while she managed her daily activities. The process helped her validate traumatic events in her history and provided a starting point for addressing internal conflicts. The client's artwork helped the therapist learn about the client's unconscious states. (MKA)

Design of an international multicentre RCT on group schema therapy for borderline personality disorder

NARCIS (Netherlands)

Wetzelaer, P.; Farrell, J.; Evers, S.M.A.A.; Jacob, G.A.; Lee, C.W.; Brand, O.; van Breukelen, G.; Fassbinder, E.; Fretwell, H.; Harper, R.P.; Lavender, A.; Lockwood, G.; Malogiannis, I.A.; Schweiger, U.; Startup, H.; Stevenson, T.; Zarbock, G.; Arntz, A.

2014-01-01

Background: Borderline personality disorder (BPD) is a severe and highly prevalent mental disorder. Schema therapy (ST) has been found effective in the treatment of BPD and is commonly delivered through an individual format. A group format (group schema therapy, GST) has also been developed. GST has

NARRATIVE KNOWINGNarrative and Storytelling Resources in Art Therapy

OpenAIRE

Harpaz, Ruth

2014-01-01

International audience; As professor Amia Lieblich has said, "People are story tellers by nature" (Lieblich et al., 1988). Storytelling technique is well-founded in narrative theory, phenomenology, psychoanalytic theory, trauma studies and aesthetics. Both my own research and my Art Therapy practice have been enriched by the use of narrative and storytelling as therapy interventions. Storytelling ability emanates from narrative knowledge. Notably, it is reframed as the patient's ability to us...

A Comprehensive Guide to Music Therapy

DEFF Research Database (Denmark)

Wigram, Anthony Lewis; Pedersen, Inge Nygaard; Bonde, Lars Ole

A detailed guide to music therapy from an international perspective, covering theory, practice, assessment, research and training. 2nd Edition of the first Danish Handbook in music theory, clinical practice, research and training. The Danish version "Musikterapi: Når ord ikke slår til......" was published in 2001 by KLIM, Aarhus DK. The English Edition has a more international orientation and a broader view on research and extended bibliography. The book includes a music CD and a CD rom....

Radiation Therapy Planning for Early-Stage Hodgkin Lymphoma: Experience of the International Lymphoma Radiation Oncology Group

International Nuclear Information System (INIS)

Maraldo, Maja V.; Dabaja, Bouthaina S.; Filippi, Andrea R.; Illidge, Tim; Tsang, Richard; Ricardi, Umberto; Petersen, Peter M.; Schut, Deborah A.; Garcia, John; Headley, Jayne; Parent, Amy; Guibord, Benoit; Ragona, Riccardo; Specht, Lena

2015-01-01

Purpose: Early-stage Hodgkin lymphoma (HL) is a rare disease, and the location of lymphoma varies considerably between patients. Here, we evaluate the variability of radiation therapy (RT) plans among 5 International Lymphoma Radiation Oncology Group (ILROG) centers with regard to beam arrangements, planning parameters, and estimated doses to the critical organs at risk (OARs). Methods: Ten patients with stage I-II classic HL with masses of different sizes and locations were selected. On the basis of the clinical information, 5 ILROG centers were asked to create RT plans to a prescribed dose of 30.6 Gy. A postchemotherapy computed tomography scan with precontoured clinical target volume (CTV) and OARs was provided for each patient. The treatment technique and planning methods were chosen according to each center's best practice in 2013. Results: Seven patients had mediastinal disease, 2 had axillary disease, and 1 had disease in the neck only. The median age at diagnosis was 34 years (range, 21-74 years), and 5 patients were male. Of the resulting 50 treatment plans, 15 were planned with volumetric modulated arc therapy (1-4 arcs), 16 with intensity modulated RT (3-9 fields), and 19 with 3-dimensional conformal RT (2-4 fields). The variations in CTV-to-planning target volume margins (5-15 mm), maximum tolerated dose (31.4-40 Gy), and plan conformity (conformity index 0-3.6) were significant. However, estimated doses to OARs were comparable between centers for each patient. Conclusions: RT planning for HL is challenging because of the heterogeneity in size and location of disease and, additionally, to the variation in choice of treatment techniques and field arrangements. Adopting ILROG guidelines and implementing universal dose objectives could further standardize treatment techniques and contribute to lowering the dose to the surrounding OARs

A Feminist Approach to Working with Internalized Heterosexism in Lesbians

Science.gov (United States)

Szymanski, Dawn M.

2005-01-01

This article addresses counselors' calls for more training on internalized heterosexism. Through a synthesis of the research on lesbian internalized heterosexism, the author discusses how the integration of a feminist approach can enhance college counselors' work with lesbian clients, describes 3 core feminist therapy principles, uses these…

"Music Therapy Helped Me Get Back Doing": Perspectives of Music Therapy Participants in Mental Health Services.

Science.gov (United States)

McCaffrey, Tríona; Edwards, Jane

2016-01-01

Mental health service development internationally is increasingly informed by the collaborative ethos of recovery. Service user evaluation of experiences within music therapy programs allows new phenomena about participation in services to be revealed that might otherwise remain unnoticed. The aim of this study was to demonstrate how asking service users about their experience of music therapy can generate useful information, and to reflect upon the feedback elicited from such processes in order to gain a deeper understanding of how music therapy is received among service users in mental health. Six mental health service users described their experiences of music therapy in one or two individual interviews. Transcripts of interviews were analyzed using the procedures and techniques of Interpretative Phenomenological Analysis. Interviews with mental health service users provided rich, in-depth accounts reflecting the complex nature of music therapy participation. Super-ordinate themes refer to the context in which music therapy was offered, the rich sound world of music in music therapy, the humanity of music therapy, and the strengths enhancing opportunities experienced by service users. Participants indicated that they each experienced music therapy in unique ways. Opinions about the value of music therapy were revealed through an interview process in which the researcher holds an open attitude, welcoming all narrative contributions respectfully. These findings can remind practitioners of the importance of closely tuning into the perspectives and understandings of those who have valuable expertise to share about their experience of music therapy services in mental health. © the American Music Therapy Association 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT).

Science.gov (United States)

Bourin, Philippe; Bunnell, Bruce A; Casteilla, Louis; Dominici, Massimo; Katz, Adam J; March, Keith L; Redl, Heinz; Rubin, J Peter; Yoshimura, Kotaro; Gimble, Jeffrey M

2013-06-01

Adipose tissue is a rich and very convenient source of cells for regenerative medicine therapeutic approaches. However, a characterization of the population of adipose-derived stromal and stem cells (ASCs) with the greatest therapeutic potential remains unclear. Under the authority of International Federation of Adipose Therapeutics and International Society for Cellular Therapy, this paper sets out to establish minimal definitions of stromal cells both as uncultured stromal vascular fraction (SVF) and as an adherent stromal/stem cells population. Phenotypic and functional criteria for the identification of adipose-derived cells were drawn from the literature. In the SVF, cells are identified phenotypically by the following markers: CD45-CD235a-CD31-CD34+. Added value may be provided by both a viability marker and the following surface antigens: CD13, CD73, CD90 and CD105. The fibroblastoid colony-forming unit assay permits the evaluation of progenitor frequency in the SVF population. In culture, ASCs retain markers in common with other mesenchymal stromal/stem cells (MSCs), including CD90, CD73, CD105, and CD44 and remain negative for CD45 and CD31. They can be distinguished from bone-marrow-derived MSCs by their positivity for CD36 and negativity for CD106. The CFU-F assay is recommended to calculate population doublings capacity of ASCs. The adipocytic, chondroblastic and osteoblastic differentiation assays serve to complete the cell identification and potency assessment in conjunction with a quantitative evaluation of the differentiation either biochemically or by reverse transcription polymerase chain reaction. The goal of this paper is to provide initial guidance for the scientific community working with adipose-derived cells and to facilitate development of international standards based on reproducible parameters. Copyright © 2013 International Society for Cellular Therapy. All rights reserved.

CERN celebrates 50 years in Geneva

CERN Multimedia

2004-01-01

Exploring the mysteries of the universe is too vast an undertaking for any one laboratory or nation. Over the past 50 years, CERN, the European Organization for Nuclear Research, has drawn together physicists froma ll over the world into this great scientific adventure. in doing so, it has become a symbol of what peaceful international collaboration can accomplish. For many, it is also a symbol of the special international spirit of Geneva (2 pages)

Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)

Science.gov (United States)

Huang, Hongyun; Young, Wise; Chen, Lin; Feng, Shiqing; Zoubi, Ziad M. Al; Sharma, Hari Shanker; Saberi, Hooshang; Moviglia, Gustavo A.; He, Xijing; Muresanu, Dafin F.; Sharma, Alok; Otom, Ali; Andrews, Russell J.; Al-Zoubi, Adeeb; Bryukhovetskiy, Andrey S.; Chernykh, Elena R.; Domańska-Janik, Krystyna; Jafar, Emad; Johnson, W. Eustace; Li, Ying; Li, Daqing; Luan, Zuo; Mao, Gengsheng; Shetty, Ashok K.; Siniscalco, Dario; Skaper, Stephen; Sun, Tiansheng; Wang, Yunliang; Wiklund, Lars; Xue, Qun; You, Si-Wei; Zheng, Zuncheng; Dimitrijevic, Milan R.; Masri, W. S. El; Sanberg, Paul R.; Xu, Qunyuan; Luan, Guoming; Chopp, Michael; Cho, Kyoung-Suok; Zhou, Xin-Fu; Wu, Ping; Liu, Kai; Mobasheri, Hamid; Ohtori, Seiji; Tanaka, Hiroyuki; Han, Fabin; Feng, Yaping; Zhang, Shaocheng; Lu, Yingjie; Zhang, Zhicheng; Rao, Yaojian; Tang, Zhouping; Xi, Haitao; Wu, Liang; Shen, Shunji; Xue, Mengzhou; Xiang, Guanghong; Guo, Xiaoling; Yang, Xiaofeng; Hao, Yujun; Hu, Yong; Li, Jinfeng; AO, Qiang; Wang, Bin; Zhang, Zhiwen; Lu, Ming; Li, Tong

2018-01-01

Cell therapy has been shown to be a key clinical therapeutic option for central nervous system diseases or damage. Standardization of clinical cell therapy procedures is an important task for professional associations devoted to cell therapy. The Chinese Branch of the International Association of Neurorestoratology (IANR) completed the first set of guidelines governing the clinical application of neurorestoration in 2011. The IANR and the Chinese Association of Neurorestoratology (CANR) collaborated to propose the current version “Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)”. The IANR council board members and CANR committee members approved this proposal on September 1, 2016, and recommend it to clinical practitioners of cellular therapy. These guidelines include items of cell type nomenclature, cell quality control, minimal suggested cell doses, patient-informed consent, indications for undergoing cell therapy, contraindications for undergoing cell therapy, documentation of procedure and therapy, safety evaluation, efficacy evaluation, policy of repeated treatments, do not charge patients for unproven therapies, basic principles of cell therapy, and publishing responsibility. PMID:29637817

Engineering toxins for 21st century therapies.

Science.gov (United States)

Chaddock, John A; Acharya, K Ravi

2011-04-01

'Engineering Toxins for 21st Century Therapies' (9-10 September 2010) was part of the Royal Society International Seminar series held at the Kavli International Centre, UK. Participants were assembled from a range of disciplines (academic, industry, regulatory, public health) to discuss the future potential of toxin-based therapies. The meeting explored how the current structural and mechanistic knowledge of toxins could be used to engineer future toxin-based therapies. To date, significant progress has been made in the design of novel recombinant biologics based on domains of natural toxins, engineered to exhibit advantageous properties. The meeting concluded, firstly that future product development vitally required the appropriate combination of creativity and innovation that can come from the academic, biotechnology and pharma sectors. Second, that continued investigation into understanding the basic science of the toxins and their targets was essential in order to develop new opportunities for the existing products and to create new products with enhanced properties. Finally, it was concluded that the clinical potential for development of novel biologics based on toxin domains was evident. © 2011 The Authors Journal compilation © 2011 FEBS.

Review of the 25th annual scientific meeting of the International Society for Biological Therapy of Cancer

Directory of Open Access Journals (Sweden)

Jaffee Elizabeth M

2011-05-01

Full Text Available Abstract Led by key opinion leaders in the field, the 25th Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc, recently renamed the Society for Immunotherapy of Cancer, SITC provided a scientific platform for ~500 attendees to exchange cutting-edge information on basic, clinical, and translational research in cancer immunology and immunotherapy. The meeting included keynote addresses on checkpoint blockade in cancer therapy and recent advances in therapeutic vaccination against cancer induced by Human Papilloma Virus 16. Participants from 29 countries interacted through oral presentations, panel discussions, and posters on topics that included dendritic cells and cancer, targeted therapeutics and immunotherapy, innate/adaptive immune interplay in cancer, clinical trial endpoints, vaccine combinations, countering negative regulation, immune cell trafficking to tumor microenvironment, and adoptive T cell transfer. In addition to the 50 oral presentations and >180 posters on these topics, a new SITC/iSBTc initiative to create evidence-based Cancer Immunotherapy Guidelines was announced. The SITC/iSBTc Biomarkers Taskforce announced the release of recommendations on immunotherapy biomarkers and a highly successful symposium on Immuno-Oncology Biomarkers that took place on the campus of the National Institutes of Health (NIH immediately prior to the Annual Meeting. At the Annual Meeting, the NIH took the opportunity to publicly announce the award of the U01 grant that will fund the Cancer Immunotherapy Trials Network (CITN. In summary, the Annual Meeting gathered clinicians and scientists from academia, industry, and regulatory agencies from around the globe to interact and exchange important scientific advances related to tumor immunobiology and cancer immunotherapy.

Role of the blood service in cellular therapy.

Science.gov (United States)

Rebulla, Paolo; Giordano, Rosaria

2012-05-01

Cellular therapy is a novel form of medical or surgical treatment using cells in place of or in addition to traditional chemical drugs. The preparation of cellular products - called advanced therapy medicinal products - ATMP in Europe, requires compliance with good manufacturing practices (GMP). Based on long-term experience in blood component manufacturing, product traceability and hemovigilance, selected blood services may represent ideal settings for the development and experimental use of ATMP. International harmonization of the protocols and procedures for the preparation of ATMP is of paramount importance to facilitate the development of multicenter clinical trials with adequate sample size, which are urgently needed to determine the clinical efficacy of ATMP. This article describes European regulations on cellular therapy and summarizes the activities of the 'Franco Calori' Cell Factory, a GMP unit belonging to the department of regenerative medicine of a large public university hospital, which acquired a certification for the GMP production of ATMP in 2007 and developed nine experimental clinical protocols during 2003-2011. Copyright © 2011 The International Alliance for Biological Standardization. Published by Elsevier Ltd. All rights reserved.

Using Epigenetic Therapy to Overcome Chemotherapy Resistance.

Science.gov (United States)

Strauss, Julius; Figg, William D

2016-01-01

It has been known for decades that as cancer progresses, tumors develop genetic alterations, making them highly prone to developing resistance to therapies. Classically, it has been thought that these acquired genetic changes are fixed. This has led to the paradigm of moving from one cancer therapy to the next while avoiding past therapies. However, emerging data on epigenetic changes during tumor progression and use of epigenetic therapies have shown that epigenetic modifications leading to chemotherapy resistance have the potential to be reversible with epigenetic therapy. In fact, promising clinical data exist that treatment with epigenetic agents can diminish chemotherapy resistance in a number of tumor types including chronic myelogenous leukemia, colorectal, ovarian, lung and breast cancer. The potential for epigenetic-modifying drugs to allow for treatment of resistant disease is exciting and clinical trials have just begun to evaluate this area. Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

External Validation and Optimization of International Consensus Clinical Target Volumes for Adjuvant Radiation Therapy in Bladder Cancer

Energy Technology Data Exchange (ETDEWEB)

Reddy, Abhinav V. [Department of Radiation and Cellular Oncology, University of Chicago Pritzker School of Medicine, Chicago, Illinois (United States); Christodouleas, John P. [Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania (United States); Wu, Tianming [Department of Radiation and Cellular Oncology, University of Chicago Pritzker School of Medicine, Chicago, Illinois (United States); Smith, Norman D.; Steinberg, Gary D. [Section of Urology, Department of Surgery, University of Chicago Pritzker School of Medicine, Chicago, Illinois (United States); Liauw, Stanley L., E-mail: sliauw@radonc.uchicago.edu [Department of Radiation and Cellular Oncology, University of Chicago Pritzker School of Medicine, Chicago, Illinois (United States)

2017-03-15

Purpose: International consensus (IC) clinical target volumes (CTVs) have been proposed to standardize radiation field design in the treatment of patients at high risk of locoregional failure (LRF) after radical cystectomy. The purpose of this study was to externally validate the IC CTVs in a cohort of postsurgical patients followed up for LRF and identify revisions that might improve the IC CTVs' performance. Methods and Materials: Among 334 patients with pT3 to pT4 bladder cancer treated with radical cystectomy, LRF developed in 58 (17%), of whom 52 had computed tomography scans available for review. Images with LRF were exported into a treatment planning system, and IC CTVs were contoured and evaluated for adequacy of coverage of each LRF with respect to both the patient and each of 6 pelvic subsites: common iliac (CI) region, obturator region (OR), external and internal iliac region, presacral region, cystectomy bed, or other pelvic site. Revisions to the IC contours were proposed based on the findings. Results: Of the 52 patients with documented LRF, 13 (25%) had LRFs that were outside of the IC CTV involving 17 pelvic subsites: 5 near the CI CTV, 5 near the OR CTV, 1 near the external and internal iliac region, and 6 near the cystectomy bed. The 5 CI failures were located superior to the CTV, and the 5 OR failures were located medial to the CTV. Increasing the superior boundary of the CI to a vessel-based definition of the aortic bifurcation, as well as increasing the medial extension of the OR by an additional 9 mm, decreased the number of patients with LRF outside of the IC CTV to 7 (13%). Conclusions: Modified IC CTVs inclusive of a slight adjustment superiorly for the CI region and medially for the OR may reduce the risk of pelvic failure in patients treated with adjuvant radiation therapy.

Funding therapies for rare diseases: an ethical dilemma with a potential solution.

Science.gov (United States)

Taylor, Colman; Jan, Stephen; Thompson, Kelly

2018-02-01

Funding rare disease therapies presents a challenge in Australia where there is a legislative requirement to consider cost-effectiveness. Currently the Life Saving Drugs Programme (LSDP) provides subsidised access to high-cost therapies for rare, life-threatening conditions. However the LSDP is currently under review by the Minsiter for Health and future access to rare disease therapies in uncertain. Internationally there is no gold standard model to evaluate and fund rare disease therapies, and considerable variation exists. However, common features of international systems include the opportunity for early stakeholder engagement, flexibility with evidence requirements, cost-effectiveness criteria and transparency in relation to the decision making framework and outcomes. Australians value equality and equal opportunity in relation to health care. To meet these expectations there is a clear need to maintain a separate fit-for-purpose framework to evaluate and fund rare disease therapies drawing on overseas best practice. This will provide certainty for industry to continue to invest in such treatments, as well as ensuring funding recommendations are reflective of Australian values balanced against the need for financial sustainability.

Clinical cell therapy guidelines for neurorestoration (China version 2016

Directory of Open Access Journals (Sweden)

Huang H

2017-02-01

Full Text Available Hongyun Huang,1 Lin Chen,2 Qingyan Zou,3 Fabin Han,4 Tiansheng Sun,5 Gengsheng Mao,1 Xijing He6 1Institute of Neurorestoratology, General Hospital of Armed Police Forces, 2Department of Neurosurgery, Yuquan Hospital, Tsinghua University, Beijing, 3Guangdong 999 Brain Hospital, Guangzhou, 4Centre for Stem Cells and Regenerative Medicine, Affiliated Hospital of Taishan Medical University, Liaocheng, Shandong, 5Department of Orthopedics, Beijing Army General Hospital, Beijing, 6Second Department of Orthopedics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China On behalf of the Chinese Association of Neurorestoratology and Chinese Branch of the International Association of Neurorestoratology Abstract: Cell therapy has been shown to be a key clinical therapeutic option for central ­nervous system disease or damage, and >30 types of cells have been identified through preclinical studies as having the capacity for neurorestoration. To standardize the clinical procedures of cell therapy as one of the strategies for treating neurological disorders, the first set of guidelines governing the clinical application of neurorestoration was completed in 2011 by the Chinese Branch of the International Association of Neurorestoratology. Given the rapidly advancing state of the field, the Neurorestoratology Professional Committee of Chinese Medical Doctor Association (Chinese Association of Neurorestoratology and the Chinese Branch of the International Association of Neurorestoratology have approved the current version known as the “Clinical Cell Therapy Guidelines for Neurorestoration (China Version 2016”. We hope this guideline will reflect the most recent results demonstrated in preclinical research, transnational studies, and evidence-based clinical studies, as well as guide clinical practice in applying cell therapy for neurorestoration. Keywords: cell therapy, neurorestoration, China, clinical

Our Journal Unites Us: Global Responsibilities and Possibilities for Pediatric Physical Therapy.

Science.gov (United States)

Van Sant, Ann F

2018-04-01

This article was designed to describe personal and social responsibilities for strengthening the science of pediatric physical therapy and effective international research collaboration and communication. Common flaws in research design and analysis are reviewed with recommendations for developing research students' design and analytical skills. Our social responsibility to be informed by global knowledge is highlighted. Barriers to scientific collaboration and communication including international disparities in scientific development and language barriers are presented. Suggestions to reduce these barriers are outlined. The importance of free access to scientific literature in developing countries is reviewed. The journal should assume a leadership role in building a strong science of pediatric physical therapy through encouraging personal and social responsibility in research and serving as a model of international collaboration and communication. Treatment for children with movement disorders will be improved by stronger science, international collaboration, and communication.

Pediatric Inpatient Headache Therapy: What is Available.

Science.gov (United States)

Kabbouche, Marielle

2015-01-01

Status migrainosus is defined by the international classification of headache disorders (ICHD) criteria as a debilitating migraine lasting more then 72 hours. The epidemiology of status migrainosus is still unknown in adult and children, and frequently underdiagnosed. Children and adolescents often end up in the emergency room with an intractable headache that failed outpatient therapy. Six to seven percent of these children do not respond to acute infusion therapy and require hospitalization. It is imperative that more aggressive therapy is considered when patients are affected by a severe intractable headache to prevent further disability and returning the child to baseline activity. Multiple therapies are available for adults and children. Studies for acute therapy in the emergency room are available in adults and pediatric groups. Small studies are available for inpatient therapy in children and, along with available therapies for children and adolescents, are described in this review. A review of the literature shows growing evidence regarding the use of dihydroergotamine intravenously once patients are hospitalized. Effectiveness and safety have been proven in the last decades in adults and small studies in the pediatric populations. © 2015 American Headache Society.

Preparing for International Travel and Global Medical Care.

Science.gov (United States)

Mahadevan, Swaminatha V; Strehlow, Matthew C

2017-05-01

Thorough pretravel preparation and medical consultation can mitigate avoidable health and safety risks. A comprehensive pretravel medical consultation should include an individualized risk assessment, immunization review, and discussion of arthropod protective measures, malaria prophylaxis, traveler's diarrhea, and injury prevention. Travel with children and jet lag reduction require additional planning and prevention strategies; travel and evacuation insurance may prove essential when traveling to less resourced countries. Consideration should also be given to other high-risk travel scenarios, including the provision of health care overseas, adventure and extreme sports, water environments and diving, high altitude, and terrorism/unstable political situations. Copyright © 2017 Elsevier Inc. All rights reserved.

Music therapy in psychiatry/mental health

DEFF Research Database (Denmark)

Pedersen, Inge Nygaard

2017-01-01

This special feature is a series of papers from a symposium held on 15th April 2016 at Aalborg University, Denmark on the topic: ‘Music therapy: A profession for the future’. The two core questions listed in the title: ‘Why music? Why and when is a music therapist needed?’ were the vehicle...... wondered if common answers to the two core questions in the profession of music therapy would emerge at an international base during the day, or if multiple ideas and subjective answers to the questions would come up. As the contributions show, it is mostly multiple ideas; yet with regard to case material......, the way of carrying out music therapy in a relationship with the users of music therapy is very similar. The theoretical understanding and ideological positions are different. There still seems to be, however, a growing integration of theories and ideas by many presenters and discussion partners...

Evolutions of Advanced Stamping CAE -- Technology Adventures and Business Impact on Automotive Dies and Stamping

International Nuclear Information System (INIS)

Wang Chuantao

2005-01-01

In the past decade, sheet metal forming and die development has been transformed to a science-based and technology-driven engineering and manufacturing enterprise from a tryout-based craft. Stamping CAE, especially the sheet metal forming simulation, as one of the core components in digital die making and digital stamping, has played a key role in this historical transition. The stamping simulation technology and its industrial applications have greatly impacted automotive sheet metal product design, die developments, die construction and tryout, and production stamping. The stamping CAE community has successfully resolved the traditional formability problems such as splits and wrinkles. The evolution of the stamping CAE technology and business demands opens even greater opportunities and challenges to stamping CAE community in the areas of (1) continuously improving simulation accuracy, drastically reducing simulation time-in-system, and improving operationalability (friendliness) (2) resolving those historically difficult-to-resolve problems such as dimensional quality problems (springback and twist) and surface quality problems (distortion and skid/impact lines) (3) resolving total manufacturability problems in line die operations including blanking, draw/redraw, trim/piercing, and flanging, and (4) overcoming new problems in forming new sheet materials with new forming techniques. In this article, the author first provides an overview of the stamping CAE technology adventures and achievements, and industrial applications in the past decade. Then the author presents a summary of increasing manufacturability needs from the formability to total quality and total manufacturability of sheet metal stampings. Finally, the paper outlines the new needs and trends for continuous improvements and innovations to meet increasing challenges in line die formability and quality requirements in automotive stamping

Single case design studies in music therapy: resurrecting experimental evidence in small group and individual music therapy clinical settings.

Science.gov (United States)

Geist, Kamile; Hitchcock, John H

2014-01-01

The profession would benefit from greater and routine generation of causal evidence pertaining to the impact of music therapy interventions on client outcomes. One way to meet this goal is to revisit the use of Single Case Designs (SCDs) in clinical practice and research endeavors in music therapy. Given the appropriate setting and goals, this design can be accomplished with small sample sizes and it is often appropriate for studying music therapy interventions. In this article, we promote and discuss implementation of SCD studies in music therapy settings, review the meaning of internal study validity and by extension the notion of causality, and describe two of the most commonly used SCDs to demonstrate how they can help generate causal evidence to inform the field. In closing, we describe the need for replication and future meta-analysis of SCD studies completed in music therapy settings. SCD studies are both feasible and appropriate for use in music therapy clinical practice settings, particularly for testing effectiveness of interventions for individuals or small groups. © the American Music Therapy Association 2014. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

The NordiNet® International Outcome Study and NovoNet® ANSWER Program®: rationale, design, and methodology of two international pharmacoepidemiological registry-based studies monitoring long-term clinical and safety outcomes of growth hormone therapy (Norditropin®).

Science.gov (United States)

Höybye, Charlotte; Sävendahl, Lars; Christesen, Henrik Thybo; Lee, Peter; Pedersen, Birgitte Tønnes; Schlumpf, Michael; Germak, John; Ross, Judith

2013-01-01

Randomized controlled trials have shown that growth hormone (GH) therapy has effects on growth, metabolism, and body composition. GH therapy is prescribed for children with growth failure and adults with GH deficiency. Carefully conducted observational study of GH treatment affords the opportunity to assess long-term treatment outcomes and the clinical factors and variables affecting those outcomes, in patients receiving GH therapy in routine clinical practice. The NordiNet® International Outcome Study (IOS) and the American Norditropin® Web Enabled Research (ANSWER Program®) are two complementary, non-interventional, observational studies that adhere to current guidelines for pharmacoepidemiological data. The studies include pediatric and adult patients receiving Norditropin®, as prescribed by their physicians. The studies gather long-term data on the safety and effectiveness of reallife treatment with the recombinant human GH, Norditropin®. We describe the origins, aims, objectives, and design methodology of the studies, as well as their governance and validity, strengths, and limitations. The NordiNet® IOS and ANSWER Program® studies will provide valid insights into the effectiveness and safety of GH treatment across a diverse and large patient population treated in accordance with real-world clinical practice and following the Good Pharmacoepidemiological Practice and STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) guidelines.

Relationship between internal dosimetry and DNA double strand breaks in lymphocytes after radionuclide therapy; Zusammenhang zwischen physikalischer Dosimetrie und DNA Doppelstrangbruechen in Lymphozyten nach Radionuklidtherapie

Energy Technology Data Exchange (ETDEWEB)

Eberlein, Uta

2015-09-30

In radionuclide therapy radiopharmaceuticals are administered mostly systemically. Primarily, beta-emitters are used because of their short range in tissue. As a result the radiopharmaceutical distributes within the human body and accumulates in organs and target structures. Thus, the body is irradiated internally, in contrast to external irradiation in radiotherapy. The pattern of the activity distribution within the human body is determined by the physical and chemical properties of the radiopharmaceutical. Furthermore, the amount of activity and its accumulation in organs or tissues is essential for the calculation of the absorbed dose which defines the energy deposited in the body by ionizing radiation. During internal or external irradiation, patients are exposed to ionizing radiation which does not only destroy the malignant cells but also damages healthy tissue and cells. This is mainly caused by direct and indirect interaction of the radiation with the DNA which damages the DNA structure. Most frequently, there are single strand breaks and base damages. DNA double strand breaks (DSBs) are rare; nevertheless, they are the most critical lesions for cells as repairing the damage is difficult. Unrepaired or misrepaired DNA could cause mutations, chromosomal aberrations or lead to cell death. The formation of a DNA DSB in nuclear chromatin results in the rapid phosphorylation of the histone H2 variant H2AX, then called gamma-H2AX. Furthermore, DSBs also recruit the damage sensor 53BP1 to the chromatin surrounding the DSBs, which leads to 53BP1 and gamma-H2AX co-localization in the chromatin surrounding a DSB. By immunofluorescence staining with gamma-H2AX and 53BP1 antibodies those biomarkers can be addressed by microscopically visible DNA damage protein foci, this is also known as the DNA damage focus assay. With progression of DSB repair, gamma-H2AX and 53BP1 foci disappear. It is assumed that one focus corresponds to one DSB. Therefore, the number of foci per

VIIIth international symposium on nuclear medicine

International Nuclear Information System (INIS)

1986-01-01

The conference proceedings contain 92 abstracts of submitted papers dealing with various applications of radioisotopes in diagnosis and therapy. The papers were devoted to scintiscanning, radioimmunoassay, tomography, the applications of nuclear magnetic resonance and electron microscopy in different branches - oncology, cardiology, neurology, histology, gynecology, internal medicine, etc. (M.D.)

Medical Physics Staffing Needs in Diagnostic Imaging and Radionuclide Therapy: An Activity Based Approach [Endorsed by International Organization for Medical Physics

International Nuclear Information System (INIS)

2018-01-01

Over the last decades, the rapid technological development of diagnostic and interventional radiology and nuclear medicine has made them major tools of modern medicine. However, at the same time the involved risks, the growing number of procedures and the increasing complexity of the procedures require competent professional staff to ensure safe and effective patient diagnosis, treatment and management. Medical physicists (or clinically qualified medical physicists) have been recognized as vital health professionals with important and clear responsibilities related to quality and safety of applications of ionizing radiation in medicine. This publication describes an algorithm developed to determine the recommended staffing levels for clinical medical physics services in medical imaging and radionuclide therapy, based on current best practice, as described in international guidelines.

Clinical trial registration in physical therapy journals: a cross-sectional study.

Science.gov (United States)

Babu, Abraham Samuel; Veluswamy, Sundar Kumar; Rao, Pratiksha Tilak; Maiya, Arun G

2014-01-01

Clinical trial registration has become an important part of editorial policies of various biomedical journals, including a few physical therapy journals. However, the extent to which editorial boards enforce the need for trial registration varies across journals. The purpose of this study was to identify editorial policies and reporting of trial registration details in MEDLINE-indexed English-language physical therapy journals. This study was carried out using a cross-sectional design. Editorial policies on trial registration of MEDLINE-indexed member journals of the International Society of Physiotherapy Journal Editors (ISPJE) (Journal of Geriatric Physical Therapy, Journal of Hand Therapy, Journal of Neurologic Physical Therapy, Journal of Orthopaedic and Sports Physical Therapy, Journal of Physiotherapy [formerly Australian Journal of Physiotherapy], Journal of Science and Medicine in Sport, Manual Therapy, Physical Therapy, Physical Therapy in Sport, Physiotherapy, Physiotherapy Research International, Physiotherapy Theory and Practice, and Revista Brasileira de Fisioterapia) were reviewed in April 2013. Full texts of reports of clinical trials published in these journals between January 1, 2008, and December 31, 2012, were independently assessed for information on trial registration. Among the 13 journals, 8 recommended trial registration, and 6 emphasized prospective trial registration. As of April 2013, 4,618 articles were published between January 2008 and December 2012, of which 9% (417) were clinical trials and 29% (121/417) of these reported trial registration details. A positive trend in reporting of trial registration was observed from 2008 to 2012. The study was limited to MEDLINE-indexed ISPJE member journals. Editorial policies on trial registration of physical therapy journals and a rising trend toward reporting of trial registration details indicate a positive momentum toward trial registration. Physical therapy journal editors need to show

Pathways to designing and running an operational flood forecasting system: an adventure game!

Science.gov (United States)

Arnal, Louise; Pappenberger, Florian; Ramos, Maria-Helena; Cloke, Hannah; Crochemore, Louise; Giuliani, Matteo; Aalbers, Emma

2017-04-01

In the design and building of an operational flood forecasting system, a large number of decisions have to be taken. These include technical decisions related to the choice of the meteorological forecasts to be used as input to the hydrological model, the choice of the hydrological model itself (its structure and parameters), the selection of a data assimilation procedure to run in real-time, the use (or not) of a post-processor, and the computing environment to run the models and display the outputs. Additionally, a number of trans-disciplinary decisions are also involved in the process, such as the way the needs of the users will be considered in the modelling setup and how the forecasts (and their quality) will be efficiently communicated to ensure usefulness and build confidence in the forecasting system. We propose to reflect on the numerous, alternative pathways to designing and running an operational flood forecasting system through an adventure game. In this game, the player is the protagonist of an interactive story driven by challenges, exploration and problem-solving. For this presentation, you will have a chance to play this game, acting as the leader of a forecasting team at an operational centre. Your role is to manage the actions of your team and make sequential decisions that impact the design and running of the system in preparation to and during a flood event, and that deal with the consequences of the forecasts issued. Your actions are evaluated by how much they cost you in time, money and credibility. Your aim is to take decisions that will ultimately lead to a good balance between time and money spent, while keeping your credibility high over the whole process. This game was designed to highlight the complexities behind decision-making in an operational forecasting and emergency response context, in terms of the variety of pathways that can be selected as well as the timescale, cost and timing of effective actions.

Music therapy internship supervisors and preinternship students: a comparative analysis of questionnaires.

Science.gov (United States)

Knight, Andrew J

2008-01-01

The purpose of this study was to compare perceptions of professional competency between preinternship music therapy students and internship supervisors. Preinternship music therapy students and internship supervisors were asked to fill out the Internship Concerns Questionnaire (ICQ-ST, student; ICQ-SU, supervisor). Participants (N = 106) included 85 students at 16 AMTA-approved universities (n = 85), and 21 internship supervisors at active AMTA national roster internship sites (n = 21). Twenty items on the ICQ were rated on a Likert-type scale, and 1 item (Part B) asked the participant to indicate any other concerns not addressed in the ICQ. Music therapy interns and supervisors differed significantly in their mean ratings on 2 of the 20 items: "Communicating with facility staff" (p = .025) and "Maintaining client confidence" (p = .016). In both cases the student interns reported a significantly lower mean level of concern about getting assistance in these areas than did their supervisors. The present study suggests that music therapy educators may better prepare music therapy students for a successful internship by evaluating the perceptual gaps in professional training expectations between students and supervisors prior to the internship. Internship supervisors may also benefit from student's own perceptions of their knowledge and skills upon beginning the internship. Ultimately, the student is responsible for being prepared to begin the process from intern to beginning professional at the start of the internship, and to commit to gaining as much as possible from the combination of academic and clinical experiences available to them.

Postoperative adjuvant therapy of breast cancer. Oncology Overview

International Nuclear Information System (INIS)

1984-12-01

Oncology Overviews are a service of the International Cancer Research Data Bank (ICRDB) Program of the National Cancer Institute, intended to facilitate and promote the exchange of information between cancer scientists by keeping them aware of literature related to their research being published by other laboratories throughout the world. Each Oncology Overview represents a survey of the literature associated with a selected area of cancer research. It contains abstracts of articles which have been selected and organized by researchers associated with the field. Contents: Postoperative chemotherapy; Postoperative radiotherapy; Postoperative hormone therapy; Postoperative immunotherapy and chemoimmunotherapy; Postoperative multimodal therapy; Prognostic factors in postoperative adjuvant therapy

Práticas aventureiras e situações de risco no voo livre: uma análise a partir do conceito de redoma sensorial Adventurous practices and risk situations in the free flight: an analysis starting from the concept of sensorial dome

Directory of Open Access Journals (Sweden)

Jairo Antônio da Paixão

2010-09-01

Full Text Available O presente estudo analisa situações de risco na prática de voo livre por intermédio do conceito de redoma sensorial. A amostra foi constituída de 19 (dezenove praticantes da modalidade de parapente, com média de idade de 31 (trinta e um anos, considerou-se o desvio padrão com significância > This study analyzes the risk situations in the practice of free flight through the concept of sensorial dome. The sample consisted of 19 (nineteen practitioners of the paragliding, with the age middle was 31 (thirty one years old and the arithmetic absolute media considered by researches was > < 0.05%. From the method of descriptive exploratory study was concluded that that the field of technology and use appropriate equipment, though not essential guarantee the success of these actors. In the major of time, the risky situations experienced in the adventure sport, join at a first moment a true outline of extraordinary sensorial elements. However, the daily experiences observed in a given kind can take to the banalization of those elements by the apprentice, becoming ordinary sensorial elements. Such change can present implications in and for the practice of the adventure sport kinds in natural environment like, for instance, the apprentice's physical and emotional integrity.

Psychological Therapies for Auditory Hallucinations (Voices): Current Status and Key Directions for Future Research

NARCIS (Netherlands)

Thomas, N.; Hayward, M.; Peters, E; van der Gaag, M.; Bentall, R.P.; Jenner, J.; Strauss, C.; Sommer, I.E.; Johns, L.C.; Varese, F.; Gracia-Montes, J.M.; Waters, F.; Dodgson, G.; McCarthy-Jones, S.

2014-01-01

This report from the International Consortium on Hallucinations Research considers the current status and future directions in research on psychological therapies targeting auditory hallucinations (hearing voices). Therapy approaches have evolved from behavioral and coping-focused interventions,

The moderating effect of tourism by-products on the relationship between tourism core products and destination image (Sarawak, Malaysia

Directory of Open Access Journals (Sweden)

Zahari Mohd Salehuddin Mohd

2017-01-01

Full Text Available This paper reports an empirical investigation on the moderating effects of the tourism by- products in building Sarawak destination image. Using causal research design through a quantitative method, self-reported and self-administered questionnaire, this study surveyed international tourists who had visited Sarawak and experienced the state core tourism products which include purchasing the local tourism by-products. Through the descriptive and inferential statistics, some useful insights about the issue investigated were significantly obtained. It's interesting to note that besides experiencing the tourism core products, the Sarawak Tourism by-products are also catching the international tourist's attention. The moderating effect of tourism by-products on the relationship between tourism core products (culture, adventure, and nature and Sarawak destination image was empirically confirmed. In fact, in addition to the core culture, adventure and nature product, the local tourism by- products undeniably building and strengthening the image of Sarawak as a tourist destination. This promising indication is, therefore, should not be ignored by the state government, tourism authority, tour operators, the local government, hotels and other related local authorities.

Leishmaniasis in travelers: a literature review.

Science.gov (United States)

Mansueto, Pasquale; Seidita, Aurelio; Vitale, Giustina; Cascio, Antonio

2014-01-01

Leishmaniasis is a vector-borne protozoan infection whose clinical spectrum ranges from asymptomatic infection to fatal visceral leishmaniasis. Over the last decades, an increase in imported leishmaniasis cases in developed, non-endemic countries, have been pointed-out from a review of the international literature. Among the possible causes are increasing international tourism, influx of immigrants from endemic regions and military operations. The main area for the acquisition of cutaneous leishmaniasis, especially for adventure travelers on long-term trips in highly-endemic forested areas, is represented from South America, whereas popular Mediterranean destinations are emerging as the main areas to acquire visceral variant. Leishmaniasis should be considered in the diagnostic assessment of patients presenting with a compatible clinical syndrome and a history of travel to an endemic area, even if this occurred several months or years before. Adventure travelers, researchers, military personnel, and other groups of travelers likely to be exposed to sand flies in endemic areas, should receive counseling regarding leishmaniasis and appropriate protective measures. Copyright © 2014 Elsevier Ltd. All rights reserved.

Leishmaniasis, an emerging infection in travelers.

Science.gov (United States)

Pavli, Androula; Maltezou, Helena C

2010-12-01

Leishmaniasis is a vector-borne protozoan infection with a wide clinical spectrum, which ranges from asymptomatic infection to fatal visceral leishmaniasis. A review of the recent literature indicates a sharp increase in imported leishmaniasis cases in developed, non-endemic countries over the last decade, in association with increasing international tourism, military operations, and the influx of immigrants from endemic countries. South America is the main area for the acquisition of cutaneous leishmaniasis, and adventure travelers on long-term trips in highly-endemic forested areas are at particular risk. Popular Mediterranean destinations are emerging as the main areas of acquisition of visceral leishmaniasis for European travelers. Leishmaniasis should be considered in patients presenting with a compatible clinical syndrome and a history of travel to an endemic area, even if this occurred several months or years ago. Appropriate counseling should be provided to adventure travelers, military personnel, researchers, and other groups of travelers likely to be exposed to sandflies in endemic areas. Copyright © 2010 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

Treatment Guidelines for Preoperative Radiation Therapy for Retroperitoneal Sarcoma: Preliminary Consensus of an International Expert Panel

Energy Technology Data Exchange (ETDEWEB)

Baldini, Elizabeth H., E-mail: ebaldini@partners.org [Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women' s Hospital, Boston, Massachusetts (United States); Wang, Dian [Department of Radiation Oncology, Rush University Medical Center, Chicago, Illinois (United States); Haas, Rick L.M. [Department of Radiotherapy, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands); Catton, Charles N. [Department of Radiation Oncology, Princess Margaret Cancer Centre, Toronto, Ontario (Canada); Indelicato, Daniel J. [Department of Radiation Oncology, University of Florida Medical Center, Jacksonville, Florida (United States); Kirsch, David G. [Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina (United States); Roberge, David [Department of Radiation Oncology, Centre Hospitalier de l' Université de Montreal, Montreal, Quebec (Canada); Salerno, Kilian [Department of Radiation Oncology, Roswell Park Cancer Institute, Buffalo, New York (United States); Deville, Curtiland [Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Sidney Kimmel Cancer Center, Washington, DC (United States); Guadagnolo, B. Ashleigh [Department of Radiation Oncology, MD Anderson Cancer Center, Houston, Texas (United States); O' Sullivan, Brian [Department of Radiation Oncology, Princess Margaret Cancer Centre, Toronto, Ontario (Canada); Petersen, Ivy A. [Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota (United States); Le Pechoux, Cecile [Department of Radiotherapy, Institut Gustave-Roussy, Villejuif (France); Abrams, Ross A. [Department of Radiation Oncology, Rush University Medical Center, Chicago, Illinois (United States); DeLaney, Thomas F. [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States)

2015-07-01

Purpose: Evidence for external beam radiation therapy (RT) as part of treatment for retroperitoneal sarcoma (RPS) is limited. Preoperative RT is the subject of a current randomized trial, but the results will not be available for many years. In the meantime, many practitioners use preoperative RT for RPS, and although this approach is used in practice, there are no radiation treatment guidelines. An international expert panel was convened to develop consensus treatment guidelines for preoperative RT for RPS. Methods and Materials: An expert panel of 15 academic radiation oncologists who specialize in the treatment of sarcoma was assembled. A systematic review of reports related to RT for RPS, RT for extremity sarcoma, and RT-related toxicities for organs at risk was performed. Due to the paucity of high-quality published data on the subject of RT for RPS, consensus recommendations were based largely on expert opinion derived from clinical experience and extrapolation of relevant published reports. It is intended that these clinical practice guidelines be updated as pertinent data become available. Results: Treatment guidelines for preoperative RT for RPS are presented. Conclusions: An international panel of radiation oncologists who specialize in sarcoma reached consensus guidelines for preoperative RT for RPS. Many of the recommendations are based on expert opinion because of the absence of higher level evidence and, thus, are best regarded as preliminary. We emphasize that the role of preoperative RT for RPS has not been proven, and we await data from the European Organization for Research and Treatment of Cancer (EORTC) study of preoperative radiotherapy plus surgery versus surgery alone for patients with RPS. Further data are also anticipated pertaining to normal tissue dose constraints, particularly for bowel tolerance. Nonetheless, as we await these data, the guidelines herein can be used to establish treatment uniformity to aid future assessments of efficacy

Release of patients after radionuclide therapy. With contributions from the [International Commission on Radiological Protection] ICRP

International Nuclear Information System (INIS)

2009-01-01

The use of unsealed radiopharmaceuticals for treatment of disease is common practice worldwide. This approach was widely employed some years ago and, following a decline, there has recently been a resurgence of interest in it. The combination of newly accessible radionuclides, improved labelling technology and developments in biotechnology has resulted in more enthusiasm and a wider range of applications for this form of therapy. Radionuclide treatments are performed with either the patient admitted to hospital or as an outpatient only. The criteria to determine which approach is best vary considerably, and are not always closely linked with the well established standards of radiation protection practice. Safety issues for the patient, their family, associated carers, staff and the general public arise with either approach. The potential risks are from both external irradiation and contamination. The International Basic Safety Standards for Protection against Ionizing Radiation and for the Safety of Radiation Sources (BSS) specify the dose constraints and limits for all of these groups, and their more general provisions with respect to the as low as reasonably achievable principle and justification also apply. One way of managing exposures of the various groups is to control when patients are released from hospital. While they are in hospital, it is relatively easy to control exposure. Once they have returned to their family in the community, they must be advised on how to restrict the exposure of those people that they will come into contact with. Until recently, the International Commission on Radiological Protection (ICRP) did not provide specific advice in this area, and relied on the application of dose limits and constraints. However, regulators in some countries took a prescriptive approach, often using estimates of retained activity as a release criterion. These only loosely relate to dose limits. This publication attempts to bring newly available advice

Seven day Lanzarote adventure: seven innovations in university learning and teaching

Science.gov (United States)

Reavey, Duncan

2010-05-01

An annual residential field course in Lanzarote, Canary Islands, gives university students of Environmental Science, Adventure Education, and Primary Science Education diverse opportunities for deep learning that challenges and motivates. Comments from students range from 'the best chemistry lesson ever' to 'life-changing'. Here I reflect on seven strengths from the student experience: (1) Our goal is for students to learn to ask scientific questions. Anyone can answer questions, but only the best scientists can ask questions that matter. (2) Field work fits the diverse learning styles of our diverse students. For example, students model bathymetry using sand and pebbles on a beach; students start to explore social issues around waste disposal on Lanzarote by taking part in a commando raid on a municipal rubbish tip! (3) Students learn from local experts but then learn from each other. For example, half the group explores agricultural practices while the other half explores traditional uses of plants; a student from one group is then paired with a student from the other group for them to teach each other what they have learned. (4) An overview of current research on the island (volcanic origins, indigenous species, trace elements in the wines!) comes from students reflecting on abstracts of 25 recent papers from mainstream journals and sharing their understanding with each other. (5) We replicate a real world experience. One part of the student assessment requires them to write a grant application for a scientific research project using the real-world pro forma and meeting the criteria set out by the real-world funding agency. (6) Students work as teams to write these grant applications (as they would do in the real world). They receive a single mark for their work, but the students then divide the mark among themselves according to the quality of the contributions they have made. In this way the university teachers assess the product, and the students assess the

Panoramic view of the Fifth International Symposium on Stem Cell Therapy and Applied Cardiovascular Biotechnology, April 2008, Madrid (Spain).

Science.gov (United States)

Villa, Adolfo; Sanz, Ricardo; Fernandez, M Eugenia; Elizaga, Jaime; Ludwig, Indrig; Sanchez, Pedro L; Fernandez-Aviles, Francisco

2009-03-01

The Fifth International Symposium on Stem Cell Therapy and Applied Cardiovascular Biotechnology was held on April 24th-25th, 2008, at the Auditorium of the High Council of Scientific Research of Spain (CSIC) in Madrid, as a continuation of a series of yearly meetings, organized in an attempt to encourage translational research in this field and facilitate a positive interaction among experts from several countries, along with industry representatives and journalists. In addition, members of the Task Force of the European Society concerning the clinical investigation of the use of autologous adult stem cells for repair of the heart gathered and discussed an update of the previous consensus, still pending of publication. In this article, we summarize some of the main topics of discussion, the state-of-the-art and latest advances in this field, and new challenges brought up for the near future.

Adequate irradiation of the internal jugular lymph node chain: technical considerations

International Nuclear Information System (INIS)

Aref, Amr; Gross, Martin; Fontanesi, James; Devi, Syamala; Kopel, Christine; Thornton, Dale

1997-01-01

Purpose: This research aimed to study the anatomic relationship between the internal jugular vein with the surrounding internal jugular lymph node chain and the underlying bony anatomical structures which are commonly used as landmarks for radiation therapy planning. Methods and Materials: Twelve patients with carcinoma of the head and neck region were studied prospectively. Using our three-dimensional planning system, a beam's-eye view of the internal jugular vein was projected onto a lateral and anterior simulation film. Quantitative measurements were made in every case of the anatomic relationship between the internal jugular vein and the posterior border of the cervical vertebrae and sagittal midline. Results: The distance between the posterior border of the internal jugular vein and the posterior border of the cervical vertebrae ranged between 0 and 2.5 cm. The distances between the sagittal midline and the medial border of the internal jugular veins ranged between 2 and 4 cm. Conclusion: To ensure adequate irradiation of the internal jugular lymph nodes, the posterior border of the lateral radiation therapy upper-neck fields should be placed at least 1 cm posterior to the posterior aspect of the cervical vertebrae. The midline block used in the lower neck anterior field should not exceed 2 cm in width

In my own words: the translation of reporting verbs on the parallel corpus the adventures of Huckleberry Finn — As aventuras de Huck

Directory of Open Access Journals (Sweden)

Daniel Alves

2015-06-01

Full Text Available http://dx.doi.org/10.5007/2175-7968.2016v36n1p34 This article examines Monteiro Lobato’s (retextualization of Mark Twain’s The Adventures of Huckleberry Finn. The analysis focuses on reporting verbs in instances of direct speech. The methodology used for data collection is based on Corpus Linguistics and the analysis built on the hallidayan systemic-functional grammar. The aim of this paper is to explore patterns in the choice of reporting verbs in Twain’s and Lobato’s textualizations particularly in connection with neutral verbs, such as ‘say’ in English and ‘dizer’ in Portuguese. Results show that Lobato’s (retextualization tends to select Free Direct Discourse, (instead of Direct Discourse and a wider variety of reporting verbs, there being no single verb accounting for more than 25% of all occurrences of direct discourse examined. The neutral verb ‘say’ was also observed to have been (retextualized by reporting verbs that signal speech function, indicating either information giving or demanding, and by verbs that realize an additional feature or specify speech connotation.

TIME-A - an international RCT on the effectiveness of music therapy in ASD

DEFF Research Database (Denmark)

Geretsegger, Monika

2014-01-01

disorders (ASD). However, generalisability of previous findings has been restricted, as studies were limited in either methodological accuracy or the clinical relevance of their approach. TIME-A is hosted by the Grieg Academy Music Therapy Research Centre, Bergen/Norway, and sets out to examine whether...... improvisational music therapy is superior to standard care in improving social communication in children with ASD over a 5-month treatment period. Funded by the Research Council of Norway, and building upon a collaboration of nine countries worldwide, TIME-A aims to include a total of 300 children with ASD aged...

Cervical Artery Dissection and Choosing Appropriate Therapy.

Science.gov (United States)

Lau, Jonathan T; Hunt, John S; Bruner, David I; Austin, Andrea L

2017-08-01

Cervical artery dissection is a common cause of stroke in young adults. This may result from head and neck trauma; it can also occur spontaneously or secondary to genetic connective tissue or vascular disorders. Neurologic symptoms arise as a result of thromboembolism and hypoperfusion causing cerebral ischemia. We present a case of a previously healthy male who was found to have a cervical internal carotid artery dissection and the decision to use antiplatelet therapy instead of anticoagulation to prevent stroke. Data is lacking regarding the efficacy of one therapy over the other.

Cervical Artery Dissection and Choosing Appropriate Therapy

Directory of Open Access Journals (Sweden)

Jonathan T. Lau

2017-07-01

Full Text Available Cervical artery dissection is a common cause of stroke in young adults. This may result from head and neck trauma; it can also occur spontaneously or secondary to genetic connective tissue or vascular disorders. Neurologic symptoms arise as a result of thromboembolism and hypoperfusion causing cerebral ischemia. We present a case of a previously healthy male who was found to have a cervical internal carotid artery dissection and the decision to use antiplatelet therapy instead of anticoagulation to prevent stroke. Data is lacking regarding the efficacy of one therapy over the other.

A roadmap for cost-of-goods planning to guide economic production of cell therapy products.

Science.gov (United States)

Lipsitz, Yonatan Y; Milligan, William D; Fitzpatrick, Ian; Stalmeijer, Evelien; Farid, Suzanne S; Tan, Kah Yong; Smith, David; Perry, Robert; Carmen, Jessica; Chen, Allen; Mooney, Charles; Fink, John

2017-12-01

Cell therapy products are frequently developed and produced without incorporating cost considerations into process development, contributing to prohibitively costly products. Herein we contextualize individual process development decisions within a broad framework for cost-efficient therapeutic manufacturing. This roadmap guides the analysis of cost of goods (COG) arising from tissue procurement, material acquisition, facility operation, production, and storage. We present the specific COG considerations related to each of these elements as identified through a 2013 International Society for Cellular Therapy COG survey, highlighting the differences between autologous and allogeneic products. Planning and accounting for COG at each step in the production process could reduce costs, allowing for more affordable market pricing to improve the long-term viability of the cell therapy product and facilitate broader patient access to novel and transformative cell therapies. Copyright © 2017 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.

Respiratory gating based on internal electromagnetic motion monitoring during stereotactic liver radiation therapy: First results.

Science.gov (United States)

Poulsen, Per Rugaard; Worm, Esben Schjødt; Hansen, Rune; Larsen, Lars Peter; Grau, Cai; Høyer, Morten

2015-01-01

Intrafraction motion may compromise the target dose in stereotactic body radiation therapy (SBRT) of tumors in the liver. Respiratory gating can improve the treatment delivery, but gating based on an external surrogate signal may be inaccurate. This is the first paper reporting on respiratory gating based on internal electromagnetic monitoring during liver SBRT. Two patients with solitary liver metastases were treated with respiratory-gated SBRT guided by three implanted electromagnetic transponders. The treatment was delivered in end-exhale with beam-on when the centroid of the three transponders deviated less than 3 mm [left-right (LR) and anterior-posterior (AP) directions] and 4mm [cranio-caudal (CC)] from the planned position. For each treatment fraction, log files were used to determine the transponder motion during beam-on in the actual gated treatments and in simulated treatments without gating. The motion was used to reconstruct the dose to the clinical target volume (CTV) with and without gating. The reduction in D95 (minimum dose to 95% of the CTV) relative to the plan was calculated for both treatment courses. With gating the maximum course mean (standard deviation) geometrical error in any direction was 1.2 mm (1.8 mm). Without gating the course mean error would mainly increase for Patient 1 [to -2.8 mm (1.6 mm) (LR), 7.1 mm (5.8 mm) (CC), -2.6 mm (2.8mm) (AP)] due to a large systematic cranial baseline drift at each fraction. The errors without gating increased only slightly for Patient 2. The reduction in CTV D95 was 0.5% (gating) and 12.1% (non-gating) for Patient 1 and 0.3% (gating) and 1.7% (non-gating) for Patient 2. The mean duty cycle was 55%. Respiratory gating based on internal electromagnetic motion monitoring was performed for two liver SBRT patients. The gating added robustness to the dose delivery and ensured a high CTV dose even in the presence of large intrafraction motion.

The validity and internal structure of the Bipolar Depression Rating Scale: data from a clinical trial of N-acetylcysteine as adjunctive therapy in bipolar disorder.

Science.gov (United States)

Berk, Michael; Dodd, Seetal; Dean, Olivia M; Kohlmann, Kristy; Berk, Lesley; Malhi, Gin S

2010-10-01

Berk M, Dodd S, Dean OM, Kohlmann K, Berk L, Malhi GS. The validity and internal structure of the Bipolar Depression Rating Scale: data from a clinical trial of N-acetylcysteine as adjunctive therapy in bipolar disorder. The phenomenology of unipolar and bipolar disorders differ in a number of ways, such as the presence of mixed states and atypical features. Conventional depression rating instruments are designed to capture the characteristics of unipolar depression and have limitations in capturing the breadth of bipolar disorder. The Bipolar Depression Rating Scale (BDRS) was administered together with the Montgomery Asberg Rating Scale (MADRS) and Young Mania Rating Scale (YMRS) in a double-blind randomised placebo-controlled clinical trial of N-acetyl cysteine for bipolar disorder (N = 75). A factor analysis showed a two-factor solution: depression and mixed symptom clusters. The BDRS has strong internal consistency (Cronbach's alpha = 0.917), the depression cluster showed robust correlation with the MADRS (r = 0.865) and the mixed subscale correlated with the YMRS (r = 0.750). The BDRS has good internal validity and inter-rater reliability and is sensitive to change in the context of a clinical trial.

Failure, Remediation, and Success in Physical Therapy Clinical Education: Is Mindfulness Present?

Science.gov (United States)

Willgens, Annette

2013-01-01

Mindfulness, a purposeful and nonjudgmental awareness of internal affective states, is emerging rapidly in the field of occupational therapy and medicine, but has not yet gained credibility in the education of the physical therapy profession. Some students lack the self-awareness needed to act on professional values, which prevents them from…

What Colour Is a Polar Bear's Skin?

Science.gov (United States)

Truchot, Sandrine; Weber, Agathe

2005-01-01

The association "Participe Futur", based in France, has set up a fantastic sailing and educational adventure with the help of the International Polar Foundation. A group of scientists left the South of France on 20 March 2005 on a sailing boat named "Alcyon". They will be on board for nine months, travelling all the way from…

Wearable Therapy - Detecting Information from Wearables and Mobiles that are Relevant to Clinical and Self-directed Therapy.

Science.gov (United States)

Arnrich, Bert; Ersoy, Cem; Mayora, Oscar; Dey, Anind; Berthouze, Nadia; Kunze, Kai

2017-01-09

This accompanying editorial provides a brief introduction into the focus theme "Wearable Therapy". The focus theme "Wearable Therapy" aims to present contributions which target wearable and mobile technologies to support clinical and self-directed therapy. A call for papers was announced to all participants of the "9th International Conference on Pervasive Computing Technologies for Healthcare" and was published in November 2015. A peer review process was conducted to select the papers for the focus theme. Six papers were selected to be included in this focus theme. The paper topics cover a broad range including an approach to build a health informatics research program, a comprehensive literature review of self-quantification for health self-management, methods for affective state detection of informal care givers, social-aware handling of falls, smart shoes for supporting self-directed therapy of alcohol addicts, and reference information model for pervasive health systems. More empirical evidence is needed that confirms sustainable effects of employing wearable and mobile technology for clinical and self-directed therapy. Inconsistencies between different conceptual approaches need to be revealed in order to enable more systematic investigations and comparisons.

Prevention and treatment of relapse after stem cell transplantation by cellular therapies.

Science.gov (United States)

Falkenburg, Fred; Ruggiero, Eliana; Bonini, Chaira; Porter, David; Miller, Jeff; Malard, Floran; Mohty, Mohamad; Kröger, Nicolaus; Kolb, Hans Jochem

2018-05-24

Despite recent advances in reducing therapy-related mortality after allogeneic stem cell transplantation (alloSCT) relapse remains the major cause of treatment failure and little progress has been achieved in the last decades. At the 3rd International Workshop on Biology, Prevention, and Treatment of Relapse held in Hamburg/Germany in November 2016 international experts presented and discussed recent developments in the field. Here, the potential of cellular therapies including unspecific and specific T cells, genetically modified T cells, CAR-T cells, NK-cells, and second allografting in prevention and treatment of relapse after alloSCT are summarized.

Martian Feeling: An Analogue Study to Simulate a Round-Trip to Mars using the International Space Station

Science.gov (United States)

Felix, C. V.; Gini, A.

When talking about human space exploration, Mars missions are always present. It is clear that sooner or later, humanity will take this adventure. Arguably the most important aspect to consider for the success of such an endeavour is the human element. The safety of the crew throughout a Martian mission is a top priority for all space agencies. Therefore, such a mission should not take place until all the risks have been fully understood and mitigated. A mission to Mars presents unique human and technological challenges in terms of isolation, confinement, autonomy, reliance on mission control, communication delays and adaptation to different gravity levels. Analogue environments provide the safest way to simulate these conditions, mitigate the risks and evaluate the effects of long-term space travel on the crew. Martian Feeling is one of nine analogue studies, from the Mars Analogue Path (MAP) report [1], proposed by the TP Analogue group of ISU Masters class 2010. It is an integrated analogue study which simulates the psychological, physiological and operational conditions that an international, six-person, mixed gender crew would experience on a mission to Mars. Set both onboard the International Space Station (ISS) and on Earth, the Martian Feeling study will perform a ``dress rehearsal'' of a mission to Mars. The study proposes to test both human performance and operational procedures in a cost-effective manner. Since Low Earth Orbit (LEO) is more accessible than other space-based locations, an analogue studies in LEO would provide the required level of realism to a simulated transit mission to Mars. The sustained presence of microgravity and other elements of true spaceflight are features of LEO that are neither currently feasible nor possible to study in terrestrial analogue sites. International collaboration, economics, legal and ethical issues were considered when the study was proposed. As an example of international collaboration, the ISS would

External radiation therapy in early stage prostate cancer

International Nuclear Information System (INIS)

Sandler, Howard M.

1996-01-01

Optimal therapy for adenocarcinoma of the prostate is controversial. Numerous options are available, however, comparison of results is difficult in view of the insufficiency of phase III randomized trials comparing alternative treatment strategies. These options include such strategies as no curative therapy (so-called watchful waiting), radiotherapy (external and/or internal), cryotherapy, or radical prostatectomy. Clearly, a broad spectrum of clinical approaches. When reported experiences involving radiation therapy and radical prostatectomy are compared, surgical patients tend to be younger, of earlier stage, of higher performance status, and have lower pre-therapy PSA. These prognostic factors influence the probability of disease control, and since patient selection can have a profound impact on results reporting, these issues need to be carefully controlled. A review of patients who are potentially candidates for surgery at the University of Michigan treated with conformal therapy external beam treatment, indicates that these relatively early patients are doing well. These issues will be elaborated upon further during the presentation

Immunosupportive therapies in aging

Directory of Open Access Journals (Sweden)

Tamas Fülöp

2007-04-01

subpopulations resulting from antigen exposure, and altered T cell activation pathways. However, a body of data indicates that innate immune responses, including the critical bridge between innate and adaptive immunity, and antigen presenting capacity are not completely resistant to senescence processes. The consequences of all these alterations are an increased incidence of infections, as well as possibly cancers, autoimmune disorders, and chronic inflammatory diseases. The leading question is what, if anything, can we do to prevent these deleterious changes without dangerously dysregulating the precarious balance of productive immunity versus immunopathology? There are many potential new therapeutic means now available to modulate immunosenescence and many others are expected to be available shortly. One main problem in applying these experimental therapies is ethical: there is a common feeling that as ageing is not a disease; the elderly are not sick and therefore do not require adventurous therapies with unpredictable side-effects in mostly frail individuals. Animal models are not helpful in this context. In this chapter we will first briefly review what we think we know about human immunosenescence and its consequences for the health status of elderly individuals. We will then discuss possible interventions that might one day become applicable in an appropriate ethical environment.Keywords: immunosenescence, T cells, phagocytic cells, nutrition, vaccination, exercise, CMV, inflammaging, IRP, immunorestorative therapies

Reflective Process in Play Therapy: A Practical Model for Supervising Counseling Students

Science.gov (United States)

Allen, Virginia B.; Folger, Wendy A.; Pehrsson, Dale-Elizabeth

2007-01-01

Counselor educators and other supervisors, who work with graduate student counseling interns utilizing Play Therapy, should be educated, grounded, and trained in theory, supervision, and techniques specific to Play Therapy. Unfortunately, this is often not the case. Therefore, a three step model was created to assist those who do not have specific…

Pemasaran Bagi Petualang sebagai Kegiatan Komunikasi Pemasaran

OpenAIRE

Tresnati, Ratih

2006-01-01

Marketing for Adventurer aims adventurer as its consumers. Instead of revenue-based, adventurer consumer is based on lifestyle. Their hobbies are outdoor sports such as bungee jumping, rock climbing, off-road driving, wild-river canoeing, etc. Marketing for adventurer has specific strategic: (1) STP Strategy—market segmenting, market targeting, market positioning; (2) Customer Experience Strategy (CES) as the sequel of Experiential Marketing (EM). EM focuses more on emotion touch and feelings.

Pemasaran bagi Petualang sebagai Kegiatan Komunikasi Pemasaran

OpenAIRE

Ratih Tresnati

2006-01-01

Marketing for Adventurer aims adventurer as its consumers. Instead of revenue-based, adventurer consumer is based on lifestyle. Their hobbies are outdoor sports such as bungee jumping, rock climbing, off-road driving, wild-river canoeing, etc. Marketing for adventurer has specific strategic: (1) STP Strategy—market segmenting, market targeting, market positioning; (2) Customer Experience Strategy (CES) as the sequel of Experiential Marketing (EM). EM focuses more on emotion touch and feelings.

Four-handed Chirping of Birds or, The Adventure of two Hungarian Translators with Flann O’Brien’s Book-web

Directory of Open Access Journals (Sweden)

Erika Mihálycsa

2013-03-01

Full Text Available The essay articulates the specific translation problems encountered in translating Flann O’Brien’s ludic novel At Swim-Two-Birds (1939 into Hungarian in a framework of translation studies, also drawing on research on Joyce in translation. It tackles issues such as the necessity to invent literary styles for the book’s embedded style parodies, especially where the ‘originals’ are unknown in the TL culture; and the choice of idiom/ minor language(s (Hiberno-English, as well as the Finn/Sweeny translatorese, for which a form of the TL that could function as a translated idiom had to be invented. As a possibility, harnessing Transylvanian Hungarian is explored – somewhat similarly to A. Oţoiu’s Romanian version of ASTB (2005, which also resorts to Transylvanian Romanian accents for rendering the same idiolects. Further points of interest are the issue of Gaelic red herrings and direct translations from the Gaelic; the possibilities of foreignizing language use, especially in the frame of Latinate pedantry; the strategies for rendering the (misquotes, literary references, Joycean allusions; and, last but far from least, the translators’ adventures with Flann O’Brien’s vicious puns. The essay also explores the four-handed translation process, resulting in a dialogic, and multilayered, Hungarian text that attempts to speak in as many styles and voices as the original.

Smoking Cessation through Acceptance and Commitment Therapy: A Case Report

Directory of Open Access Journals (Sweden)

Ufuk Bal

2015-12-01

Full Text Available Smoking is one of the most common addictions with devastating biopsychosocial consequences. Both medical treatment and pschotherapy are utilized in smoking cessation. Acceptance and commitment therapy holds the notion that smoking cessation rates are determined not so much by the negative affect and withdrawal symptoms per se, but by the avoidant and inflexible responding style. Acceptance and commitment therapy, through targeting the avoidance of internal stimuli and concomitant inflexible responding pattern, has yielded successful results.This article presents application of acceptance and commitment therapy step by step to a chronic smoker who quitted smoking at the end of therapy sessions. [Cukurova Med J 2015; 40(4.000: 841-846

Impact Of Equestrian Tourism On The Environment

Directory of Open Access Journals (Sweden)

Ioan Petroman

2015-05-01

Full Text Available Considereda sub-sector of horse raisin units, equestrian tourism is a form of moderntourism very popular among the young people as both an entertainingrecreational and adventure activity and a form of animal therapy in thetreatment and rehabilitation of autistic children; it is also a sub-type ofrural tourism, adventure tourism, or ecological tourism. Equestrian tourismpracticed without management strategies can have both positive and negativeeffects on the environment: it can affect roads by soil compaction, vegetationby the introduction of invasive plant species, and tourists by the noise andsmell. In order to reduce the negative effects on the environment, we need todevelop management strategies for the routes and visitors as well as for theareas where equestrian tourism is practiced; we also need to developenvironmental-friendly tourism products depending on the degree of difficulty,supplying accommodation at the horse farm and horse riding lessons,conferences, chart rides in the nature, and horseback holidays.

Music therapy: A profession for the future

DEFF Research Database (Denmark)

Pedersen, Inge Nygaard

2017-01-01

This special feature is a series of papers from a symposium held on 15th April 2016 at Aalborg University, Denmark on the topic: ‘Music therapy: A profession for the future’. The two core questions listed in the title: ‘Why music? Why and when is a music therapist needed?’ were the vehicle...... wondered if common answers to the two core questions in the profession of music therapy would emerge at an international base during the day, or if multiple ideas and subjective answers to the questions would come up. As the contributions show, it is mostly multiple ideas; yet with regard to case material......, the way of carrying out music therapy in a relationship with the users of music therapy is very similar. The theoretical understanding and ideological positions are different. There still seems to be, however, a growing integration of theories and ideas by many presenters and discussion partners...

CERN, Accelerating Science

CERN Multimedia

AUTHOR|(CDS)2086185

2015-01-01

What is the Universe made of? Where did it come from, where is it going and why does it behave the way it does? These are some of the questions that CERN set out to address when a small number of pioneering scientists created Europe’s first scientific international organization. Founded in 1954, in the aftermath of the Second World War, CERN is not only a first-class centre for fundamental research but also a pioneering adventure in international collaboration.

CERN, Accelerating Science (bilingual brochure)

CERN Multimedia

Kahle, Kate

2016-01-01

What is the Universe made of? Where did it come from, where is it going and why does it behave the way it does? These are some of the questions that CERN set out to address when a small number of pioneering scientists created Europe’s first scientific international organization. Founded in 1954, in the aftermath of the Second World War, CERN is not only a first-class centre for fundamental research but also a pioneering adventure in international collaboration.

CERN 60 years of science for peace

CERN Multimedia

Fabienne, Marcastel

2014-01-01

What is the Universe made of? Where did it come from, where is it going and why does it behave the way it does? These are some of the questions that CERN set out to address 60 years ago when a small number of pioneering scientists created Europe’s first scientific international organization. Founded in the aftermath of the second world war, CERN is not only a first-class centre for fundamental research but also a pioneering adventure in international collaboration.

Sorry It Has Taken So Long: Continuing Feminist Dialogues in Music Therapy

OpenAIRE

Sandra Curtis

2013-01-01

The impact of feminism – along with its understanding of the complex interactions in our lives of gender, race, class, sexual orientation, ability, and age – arrived late in music therapy. This paper reviews what feminist impact exists, explores possible challenges faced, and identifies the most recent endeavors in the area including the first International Conference on Gender, Health, and the Creative Arts Therapies and a gathering of feminist music therapy researchers, both hosted in Montr...

Stimulant use and its impact on growth in children receiving growth hormone therapy: an analysis of the KIGS International Growth Database.

Science.gov (United States)

Miller, Bradley S; Aydin, Ferah; Lundgren, Frida; Lindberg, Anders; Geffner, Mitchell E

2014-01-01

Children receiving stimulants for attention deficit hyperactivity disorder (ADHD) frequently present to pediatric endocrinology clinics for evaluation and treatment of growth disorders. The worldwide prevalence of stimulant use in children with ADHD also receiving recombinant human growth hormone (rhGH) and the impact on response to rhGH are unknown. Data on children enrolled in the KIGS® (Pfizer International Growth Study) registry were evaluated for the associated diagnosis of ADHD prior to initiation of Genotropin® rhGH. Concomitant stimulant medications and auxological information were captured. Response to rhGH was evaluated using established growth prediction models. The prevalence of ADHD in KIGS was 2.3% (1,748/75,251), with stimulants used in 1.8% (1,326/75,251). Children with idiopathic growth hormone deficiency (IGHD) who received stimulants grew significantly less (1.1 cm) in the first year of rhGH therapy than expected for rhGH-treated non-ADHD IGHD children. After one year of rhGH, idiopathic short stature (ISS) children with ADHD were significantly shorter [0.74 cm (with stimulants) and 0.69 cm (without stimulants)] than non-ADHD ISS children. We demonstrated an impaired response to rhGH in IGHD and ISS children with ADHD. Our findings suggest that the ADHD phenotype, alone or in conjunction with stimulant therapy, may impair the short-term growth response to rhGH.

Evolutions of Advanced Stamping CAE — Technology Adventures and Business Impact on Automotive Dies and Stamping

Science.gov (United States)

Wang, Chuantao (C. T.)

2005-08-01

In the past decade, sheet metal forming and die development has been transformed to a science-based and technology-driven engineering and manufacturing enterprise from a tryout-based craft. Stamping CAE, especially the sheet metal forming simulation, as one of the core components in digital die making and digital stamping, has played a key role in this historical transition. The stamping simulation technology and its industrial applications have greatly impacted automotive sheet metal product design, die developments, die construction and tryout, and production stamping. The stamping CAE community has successfully resolved the traditional formability problems such as splits and wrinkles. The evolution of the stamping CAE technology and business demands opens even greater opportunities and challenges to stamping CAE community in the areas of (1) continuously improving simulation accuracy, drastically reducing simulation time-in-system, and improving operationalability (friendliness), (2) resolving those historically difficult-to-resolve problems such as dimensional quality problems (springback and twist) and surface quality problems (distortion and skid/impact lines), (3) resolving total manufacturability problems in line die operations including blanking, draw/redraw, trim/piercing, and flanging, and (4) overcoming new problems in forming new sheet materials with new forming techniques. In this article, the author first provides an overview of the stamping CAE technology adventures and achievements, and industrial applications in the past decade. Then the author presents a summary of increasing manufacturability needs from the formability to total quality and total manufacturability of sheet metal stampings. Finally, the paper outlines the new needs and trends for continuous improvements and innovations to meet increasing challenges in line die formability and quality requirements in automotive stamping.

E-therapy: practical, ethical, and legal issues.

Science.gov (United States)

Manhal-Baugus, M

2001-10-01

E-therapy is a term that has been coined to describe the process of interacting with a therapist online in ongoing conversations over time when the client and counselor are in separate or remote locations and utilize electronic means to communicate with each other. It is a relatively new modality of assisting individuals resolve life and relationship issues. E-therapy utilizes the power and convenience of the internet to allow simultaneous (synchronous) and time-delayed (asynchronous) communication between an individual and a professional. For the purposes of this paper, e-therapy is defined as a licensed mental health care professional providing mental health services via e-mail, video conferencing, virtual reality technology, chat technology, or any combination of these. It does not include self-help methods such as public bulletin boards or private listservs. E-therapy is not psychotherapy or psychological counseling per se since it does to presume to diagnose or treat mental or medical disorders. However, e-therapy is flexible enough to also address many difficulties which clients present to the online therapist. As in other types of therapy, such as bibliotherapy, occupational therapy, and rehabilitation therapy), e-therapy does assist a person in addressing specific concerns with specific skills. This article examines the following issues of e-therapy. First, the types of e-therapy and related services are described to provide a background for the article. Second, the ethical codes which have been adopted by three major professional organizations (American Counseling Association, National Board for Certified Counselors, and the International Society for Mental Health Online) pertaining to e-therapy are summarized for professional and consumer use. Finally, the practical, ethical, and legal issues of e-therapy services are discussed fully.

Proceedings of the German Society of Internal Medicine

International Nuclear Information System (INIS)

Miehlke, K.

1988-01-01

The proceedings of the German Society of Internal Medicine from its 94th congress held at Wiesbaden (April 10-14, 1988) provide coverage of the following issues: Gastrointestinal tumours - diagnosis and therapy at an early stage; diagnostic methods used in the pancreas; endoscopy during surgery; medical imaging in gastroenterology; therapy of chronic inflammatory changes of the intestine; proctology on an out-patient basis and geriatric patients showing cerebrovasucular insufficiency. Three papers have been separately for the database. (GDG) With 290 figs., 248 tabs [de

Role and liabilities of the medical physicist in the validation of oncologic treatments in internal vectorized radiation therapy. S.F.P.M. report nr 31, June 2015

International Nuclear Information System (INIS)

Farman, Bardia; Defez, Didier; Martineau, Antoine; Vrigneaud, Jean-Marc; Dieudonne, Arnaud; Giraud, Fabienne; Divry, Guillaume; Bardies, Manuel; Laffont, Sophie; Santoro, Lore; Ferrer, Ludovic; Guilhem, Marie-Therese; Meyer, Philippe; Simon, Luc

2015-06-01

According to legal arrangements and decrees, the medical physicist must validate the preparation of each treatment based on the use of radio-elements in non-sealed sources. As the medical physicist is therefore liable of this validation, this report addresses the approach to be followed to comply with the law. The authors first outline that this report only concerns oncologic internal vectorized radiation therapy, and does not address the dosimetric aspect of these treatments. After having recalled the principles of internal vectorized radiography, they describe the role of the different actors: nuclear physician, medical physicist, radio-pharmacist, radio-pharmacy dispenser, medical electro-radiology operator, state nurse. They address the various aspects of the process of validation of a treatment preparation: technical prerequisites, organisational prerequisite, validation process, traceability, dosimetry. Several examples are proposed in appendix regarding traceability, dosimetry software, examples of PRM files

Pemasaran bagi Petualang sebagai Kegiatan Komunikasi Pemasaran

Directory of Open Access Journals (Sweden)

Ratih Tresnati

2006-12-01

Full Text Available Marketing for Adventurer aims adventurer as its consumers. Instead of revenue-based, adventurer consumer is based on lifestyle. Their hobbies are outdoor sports such as bungee jumping, rock climbing, off-road driving, wild-river canoeing, etc. Marketing for adventurer has specific strategic: (1 STP Strategy—market segmenting, market targeting, market positioning; (2 Customer Experience Strategy (CES as the sequel of Experiential Marketing (EM. EM focuses more on emotion touch and feelings.

Cobalt, Linac, or Other: What Is the Best Solution for Radiation Therapy in Developing Countries?

Energy Technology Data Exchange (ETDEWEB)

Page, Brandi R., E-mail: bpage@wakehealth.edu [Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina (United States); Hudson, Alana D.; Brown, Derek W. [Tom Baker Cancer Centre, University of Calgary, Calgary (Canada); Shulman, Adam C. [Overlook Medical Center, Summit, New Jersey (United States); Abdel-Wahab, May [Cleveland Clinic and Cleveland Clinic Lerner School of Medicine, Cleveland, Ohio (United States); Fisher, Brandon J. [Gamma West Cancer Services, Layton, Utah (United States); Radiating Hope, Midvale, Utah (www.radiatinghope.org) (United States); Patel, Shilpen [University of Washington, Seattle, Washington (United States)

2014-07-01

The international growth of cancer and lack of available treatment is en route to become a global crisis. With >60% of cancer patients needing radiation therapy at some point during their treatment course, the lack of available facilities and treatment programs worldwide is extremely problematic. The number of deaths from treatable cancers is projected to increase to 11.5 million deaths in 2030 because the international population is aging and growing. In this review, we present how best to answer the need for radiation therapy facilities from a technical standpoint. Specifically, we examine whether cobalt teletherapy machines or megavoltage linear accelerator machines are best equipped to handle the multitudes in need of radiation therapy treatment in the developing world.

Development of the music therapy assessment Tool for advanced Huntington’s disease: A pilot validation study

DEFF Research Database (Denmark)

O'Kelly, Julian; Bodak, Rebeka

2016-01-01

Background: Case studies of people with Huntington's disease (HD) report that music therapy provides a range of benefits that may improve quality of life; however, no robust music therapy assessment tools exist for this population. Objective: Develop and conduct preliminary psychometric testing...... of its construct validity, internal consistency, and inter-rater and intra-rater reliability over 10 group music therapy sessions with 19 patients. Results: The resulting MATA-HD included a total of 15 items across six subscales (Arousal/Attention, Physical Presentation, Communication, Musical, Cognition......, and Psychological/Behavioral). We found good construct validity (r ≥ 0.7) for Mood, Communication Level, Communication Effectiveness, Choice, Social Behavior, Arousal, and Attention items. Cronbach's α of 0.825 indicated good internal consistency across 11 items with a common focus of engagement in therapy...

International Journal of Community Research http://www.arpjournals ...

African Journals Online (AJOL)

2014-10-31

Oct 31, 2014 ... International Journal of Community Research ... Analysis was by narrative synthesis and meta-analysis. Results showed that five ..... and Therapy) was carried out electronically on the journals' websites. Study Selection and Eligibility: Potentially relevant titles, citations and abstracts were screened following.

Vital Pulp Therapy of a Mature Molar with Concurrent Hyperplastic Pulpitis, Internal Root Resorption and Periradicular Periodontitis: A Case Report.

Science.gov (United States)

Asgary, Saeed; Kemal Çalışkan, Mehmet

2015-01-01

Vital pulp therapy (VPT) of permanent mature teeth is continuously ascertaining to be a more reliable endodontic treatment. The purpose of this case report was to describe successful VPT of a mature mandibular left first molar with concurrent hyperplastic pulpitis, internal root resorption and periradicular periodontitis in a 35-year-old male patient. After complete caries removal and access cavity preparation, the dental pulp was removed from the coronal third of the roots. To protect the remaining pulp, calcium-enriched mixture (CEM) cement was placed and adapted into the cavities; the tooth was then restored with amalgam. Six months after VPT, radiographic examination showed evidence of periradicular healing. Clinically, the tooth was functional without signs and symptoms of infection/inflammation. The successful outcome of this case suggests that diseased dental pulp (i.e. irreversible pulpitis) has the potential to heal after pulp protection with CEM biocement.

Vital Pulp Therapy of a Mature Molar with Concurrent Hyperplastic Pulpitis, Internal Root Resorption and Periradicular Periodontitis: A Case Report

Science.gov (United States)

Asgary, Saeed; Kemal Çalışkan, Mehmet

2015-01-01

Vital pulp therapy (VPT) of permanent mature teeth is continuously ascertaining to be a more reliable endodontic treatment. The purpose of this case report was to describe successful VPT of a mature mandibular left first molar with concurrent hyperplastic pulpitis, internal root resorption and periradicular periodontitis in a 35-year-old male patient. After complete caries removal and access cavity preparation, the dental pulp was removed from the coronal third of the roots. To protect the remaining pulp, calcium-enriched mixture (CEM) cement was placed and adapted into the cavities; the tooth was then restored with amalgam. Six months after VPT, radiographic examination showed evidence of periradicular healing. Clinically, the tooth was functional without signs and symptoms of infection/inflammation. The successful outcome of this case suggests that diseased dental pulp (i.e. irreversible pulpitis) has the potential to heal after pulp protection with CEM biocement. PMID:26523145

The effects of brief individual cognitive behavioural therapy for depression and homesickness among international students in Malaysia.

Science.gov (United States)

Saravanan, Coumaravelou; Alias, Alizi; Mohamad, Mardiana

2017-10-01

Students who go to other countries for higher education face various psychological problems, particularly homesickness and depression. The objectives of this study were to: (a) identify differences between students who did and did not receive brief individual cognitive behavioural therapy (CBT) for depression to reduce homesickness; (b) identify whether brief individual CBT for depression reduces the level of homesickness in students between pre-, post- and follow-up assessment; and (c) compare the scores of students experiencing only homesickness and those experiencing both homesickness and depression. The sample consisted of 520 first-year undergraduate international students. The experimental group contained students who were diagnosed with depression and homesickness and received seven sessions of brief individual CBT for depression to reduce homesickness. The control group contained students who were diagnosed with depression and homesickness and received one session of advice and suggestions. The comparison group contained students who experienced only homesickness and did not receive any interventions. The study used the comparison group to determine if an interaction effect existed between students experiencing only homesickness and students experiencing both homesickness and depression. Students who received brief individual CBT displayed a significant reduction in their homesickness and depression scores compared to the scores of students in the control group. Students who experienced only homesickness exhibited a significant reduction in the scores on homesickness in the post-assessment compared to the control group's post-assessment homesickness scores. The results of this study cannot be generalized as data were collected from three universities in Malaysia. The follow-up assessment was conducted six months after the post-assessment, which also limits generalizability beyond six months. Overall, homesickness is considered a normal reaction. Brief

Occupational Therapy for School-Aged Children in India

Science.gov (United States)

Asher, Asha; Jatar, Anuradha; Bijlani, Jyothika

2015-01-01

Occupational therapists exploring international opportunities should understand how the profession is practiced globally. This paper describes the framework under which occupational therapy services can be accessed by families of children with disabilities in urban India. Background information about the country, its health care, and occupational…

Essential Palatal Tremor Managed by Cognitive Behavioral Therapy

Directory of Open Access Journals (Sweden)

Tomohisa Kitamura

2015-01-01

Full Text Available Background. Essential palatal tremor is a disorder of unknown etiology involving involuntary movement of the uvula and soft palate. Treatment attempts including drugs or surgery have been conducted to cease the rhythmical movement. Case Report. A 55-year-old female visited our department complaining of a sudden, noticeable, intermittent, and rhythmical clicking noise in her throat for five years. Oral examination revealed rhythmical contractions of the soft palate with clicking at the frequency of 120 per min. Magnetic resonance imaging (MRI examination of the brain performed after consulting with the department of neuropathic internal medicine showed no abnormalities. Thus, essential palatal tremor was diagnosed. The symptoms improved with cognitive behavioral therapy without drugs or surgical treatments. The patient is now able to stop the rhythmical movement voluntarily. Discussion. Cognitive behavioral therapy might be suitable as first-line therapy for essential palatal tremor because the therapy is noninvasive.

Influence of baseline variables on changes in International Prostate Symptom Score after combined therapy with dutasteride plus tamsulosin or either monotherapy in patients with benign prostatic hyperplasia and lower urinary tract symptoms: 4-year results of the CombAT study.

Science.gov (United States)

Roehrborn, Claus G; Barkin, Jack; Tubaro, Andrea; Emberton, Mark; Wilson, Timothy H; Brotherton, Betsy J; Castro, Ramiro

2014-04-01

To examine, using post hoc analysis, the influence of baseline variables on changes in international prostate symptom score (IPSS), maximum urinary flow rate (Qmax ) and IPSS quality of life (QoL) in patients with moderate-to-severe lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) treated with either the α-blocker tamsulosin or the dual 5-alpha reductase inhibitor dutasteride, alone or in combination, as part of the 4-year Combination of Avodart and Tamsulosin (CombAT) study. CombAT was a 4-year, multicentre, randomized, double-blind, parallel-group study in 4844 men ≥50 years of age with a clinical diagnosis of BPH by medical history and physical examination, an IPSS ≥12 points, prostate volume (PV) ≥30 mL, total serum PSA level ≥1.5 ng/mL, and Qmax >5 mL/s and ≤15 mL/s with a minimum voided volume ≥125 mL. Eligible subjects were randomized to receive oral daily tamsulosin, 0.4 mg; dutasteride, 0.5 mg; or a combination of both. Baseline variable subgroups analysed were as follows: PV (30 to tamsulosin were performed from the general linear model with statistical significance defined as P ≤ 0.01. Combination therapy resulted in a significantly greater improvement from baseline IPSS at 48 months vs tamsulosin monotherapy across all baseline subgroups. The benefit of combination therapy over dutasteride was confined to groups with lower baseline PV (tamsulosin but not dutasteride monotherapy. Qmax improvement appeared to increase with PV and PSA level in combination therapy subjects. The proportion of subjects with an IPSS QoL ≤2 (at least mostly satisfied) at 48 months was significantly higher with combination therapy than with dutasteride for subgroups with PV 40-60 mL and PSA level tamsulosin for all PSA subgroups and PV subgroups ≥40 mL. CombAT data support the use of long-term combination therapy with dutasteride and tamsulosin in patients considered at risk for progression of BPH, as determined

Pengaruh Hedonic Value Terhadap Behavioral Intention Dengan Customer Satisfaction Sebagai Variabel Intervening (Studi Kasus Pada: 1903 – Heritage Dining)

OpenAIRE

Khuana, Kevin

2016-01-01

This study aims to analyze the influence of Hedonic Value ( Adventure Shopping , Social shoping , Gratification Shopping , Idea Shopping , Role Shopping , Value Shopping) against Behavioral Intention ( Loyalty to the company, propensity to switch , Willingness to pay more , External response to the problem , internal response to the problem ) by considering factors Restaurant Customer Satisfaction ( Pace of Service, Service Overall , Server Communication & accurancy , taste & quality ...

Up Against the Wall: Primal Therapy and 'the Sixties'

Directory of Open Access Journals (Sweden)

Paul Williams

2008-09-01

Full Text Available 1. IntroductionPrimal Therapy, a form of psychological treatment based on expelling neurosis through emotional expression, was developed by the Californian psychotherapist Arthur Janov. His work became well known across the Anglophone world with the 1970 publication of The Primal Scream (subtitled Primal Therapy: The Cure for Neurosis. It is claimed this book sold more than one million copies internationally, which – if true – makes it one of the best-selling psychology books ever. In 1968 J...

A new music therapy engagement scale for persons with dementia.

Science.gov (United States)

Tan, Jane; Wee, Shiou-Liang; Yeo, Pei Shi; Choo, Juliet; Ritholz, Michele; Yap, Philip

2018-05-25

ABSTRACTObjectives:To develop and validate a new scale to assess music therapy engagement in persons with dementia (PWDs). A draft scale was derived from literature review and >2 years of qualitative recording of PWDs during music therapy. Content validity was attained through iterative consultations, trial sessions, and revisions. The final five-item Music Therapy Engagement scale for Dementia (MTED) assessed music and non-music related elements. Internal consistency and inter-rater reliability were assessed over 120 music therapy sessions. MTED was validated with the Greater Cincinnati Chapter Well-being Observation Tool, Holden Communication Scale, and Participant Engagement Observation Checklist - Music Sessions. A total of 62 PWDs (83.2 ± 7.7 years, modified version of the mini-mental state examination = 13.2/30 ± 4.1) in an acute hospital dementia unit were involved. The mean MTED score was 13.02/30 ± 4.27; internal consistency (Cronbach's α = 0.87) and inter-rater reliability (intra-class correlation = 0.96) were good. Principal component analysis revealed a one-factor structure with Eigen value > 1 (3.27), which explained 65.4% of the variance. MTED demonstrated good construct validity. The MTED total score correlated strongly with the combined items comprising Pleasure, Interest, Sadness, and Sustained attention of the Greater Cincinnati Chapter Well-being Observation Tool (rs = 0.88, p < 0.001). MTED is a clinically appropriate and psychometrically valid scale to evaluate music therapy engagement in PWDs.

DIAGNOSTICS AND THERAPY IN CHILDREN'S ACUTE GASTROENTERITIS

Directory of Open Access Journals (Sweden)

M.D. Bakradze

2007-01-01

Full Text Available The work aimed at studying a series of diagnostic aspects and determination of the possible treatment of children with acute gastroenetrites according to the protocol based on international recommendations and standards. The study involved 130 children, of whom in 71 patients the presence of rotavirus antigen in coprofilters was checked via latex particle agglutination method. In 85% rotavirus infection was confirmed. It was shown that the majority of cases fall on November to may. Infant and early children are the most susceptible to rotavirus gastroenteritis. The analysis of therapy results showed that antibioticsfree treatment of watery diarrhea patients worked well, and prescription of antibacterial therapy for the concomitant bacterial infection does not influence the time of gastroenteritis reduction. The results of dehydration therapy show that oral rehydration is not always effective for the 2nd stage dehydration, especially with late treatment. However, the time of recovery (diarrhea reduction does not depend on the type of rehydration or symptomatic therapy. A diagnostic algorithm that helps use the minimum diagnostic methods in stationary conditions and at the same time provides the optimum scope of therapeutic intervention was worked out.Key words: rotavirus infection, children, rehydration, antibacterial therapy.

Internal drainage of infected pancreatic pseudocysts: safe or sorry?

NARCIS (Netherlands)

Boerma, D.; van Gulik, T. M.; Obertop, H.; Gouma, D. J.

1999-01-01

BACKGROUND: External drainage is the traditional surgical therapy for infected pancreatic pseudocyst, although associated with high morbidity and mortality rates. In this study it was determined whether internal drainage is feasible with acceptable postoperative morbidity and recurrence rates.

Is electroconvulsive therapy during pregnancy safe?

Science.gov (United States)

Jiménez-Cornejo, Magdalena; Zamorano-Levi, Natalia; Jeria, Álvaro

2016-12-07

Therapeutic options for psychiatric conditions are limited during pregnancy because many drugs are restricted or contraindicated. Electroconvulsive therapy constitutes an alternative, however there is controversy over its safety. Using the Epistemonikos database, which is maintained by searching multiple databases, we found five systematic reviews, including 81 studies overall describing case series or individual cases. Data were extracted from the identified reviews and summary tables of the results were prepared using the GRADE method. We concluded it is not clear what are the risks associated with electroconvulsive therapy during pregnancy because the certainty of the existing evidence is very low. Likewise, existing systematic reviews and international clinical guidelines differ in their conclusions and recommendations.

Status report : British Columbia`s economic plan

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-01-01

A sector-by-sector update of actions taken under British Columbia`s three-year economic plan is outlined and the progress to date reviewed. The three year plan includes the support for industry growth in partnership with the private sector, making Vancouver a major international conference destination, and developing Vancouver International Airport into a major gateway to the Pacific. The plan also includes the promotion of adventure tourism in major international markets, and promoting aboriginal tourism and culture. The government also plans to stimulate the economy by providing $973 million in tax reductions for BC families and business. 1 tab.

Interleukin-2 therapy in patients with HIV infection

DEFF Research Database (Denmark)

Abrams, D; Lévy, Y; Losso, M H

2009-01-01

Interleukin-2 in HIV-Infected Patients with Low CD4+ Counts under Active Antiretroviral Therapy (SILCAAT) study and the Evaluation of Subcutaneous Proleukin in a Randomized International Trial (ESPRIT). In each, patients infected with the human immunodeficiency virus (HIV) who had CD4+ cell counts of either...

Homeward Journey through Poetry: Wallace Stevens’s The Poem that Took the Place of a Mountain

Directory of Open Access Journals (Sweden)

Prohászka-Rád Boróka

2015-12-01

Full Text Available Analyzing Stevens’s 1952 The Poem that Took the Place of a Mountain I trace the laborious journey the persona of the poem undertakes - an external as well as an internal adventure - transforming thus the world into a possible home. I show how the poem - through its self-reflexive nature and complex system of interwoven external and internal images and circular movements - may offer the persona a sense of self and home in space and time among the fragments of the broken universe.