WorldWideScience

Sample records for internal linear combination

  1. Exploring 2-spin internal linear combinations for the recovery of the CMB polarization

    CERN Document Server

    Fernández-Cobos, R; Vielva, P; Martínez-González, E; Barreiro, R B

    2016-01-01

    We present a methodology to recover cosmic microwave background (CMB) polarization in which the quantity $P = Q+ iU$ is linearly combined at different frequencies using complex coefficients. This is the most general linear combination of the $Q$ and $U$ Stokes parameters which preserves the physical coherence of the residual contribution on the CMB estimation. The approach is applied to the internal linear combination (ILC) and the internal template fitting (ITF) methodologies. The variance of $P$ of the resulting map is minimized to compute the coefficients of the linear combination. One of the key aspects of this procedure is that it serves to account for a global frequency-dependent shift of the polarization phase. Although in the standard case, in which no global E-B transference depending on frequency is expected in the foreground components, minimizing $\\left\\langle |P|^2\\right\\rangle$ is similar to minimizing $\\left\\langle Q^2\\right\\rangle$ and $\\left\\langle U^2\\right\\rangle$ separately (as previous me...

  2. SILC: a new Planck internal linear combination CMB temperature map using directional wavelets

    Science.gov (United States)

    Rogers, Keir K.; Peiris, Hiranya V.; Leistedt, Boris; McEwen, Jason D.; Pontzen, Andrew

    2016-08-01

    We present new clean maps of the cosmic microwave background (CMB) temperature anisotropies (as measured by Planck) constructed with a novel internal linear combination (ILC) algorithm using directional, scale-discretized wavelets - scale-discretized, directional wavelet ILC or Scale-discretised, directional wavelet Internal Linear Combination (SILC). Directional wavelets, when convolved with signals on the sphere, can separate the anisotropic filamentary structures which are characteristic of both the CMB and foregrounds. Extending previous component separation methods, which use the frequency, spatial and harmonic signatures of foregrounds to separate them from the cosmological background signal, SILC can additionally use morphological information in the foregrounds and CMB to better localize the cleaning algorithm. We test the method on Planck data and simulations, demonstrating consistency with existing component separation algorithms, and discuss how to optimize the use of morphological information by varying the number of directional wavelets as a function of spatial scale. We find that combining the use of directional and axisymmetric wavelets depending on scale could yield higher quality CMB temperature maps. Our results set the stage for the application of SILC to polarization anisotropies through an extension to spin wavelets.

  3. SILC: a new Planck Internal Linear Combination CMB temperature map using directional wavelets

    CERN Document Server

    Rogers, Keir K; Leistedt, Boris; McEwen, Jason D; Pontzen, Andrew

    2016-01-01

    We present new clean maps of the CMB temperature anisotropies (as measured by Planck) constructed with a novel internal linear combination (ILC) algorithm using directional, scale-discretised wavelets --- Scale-discretised, directional wavelet ILC or SILC. Directional wavelets, when convolved with signals on the sphere, can separate the anisotropic filamentary structures which are characteristic of both the CMB and foregrounds. Extending previous component separation methods, which use the frequency, spatial and harmonic signatures of foregrounds to separate them from the cosmological background signal, SILC can additionally use morphological information in the foregrounds and CMB to better localise the cleaning algorithm. We test the method on Planck data and simulations, demonstrating consistency with existing component separation algorithms, and discuss how to optimise the use of morphological information by varying the number of directional wavelets as a function of spatial scale. We find that combining t...

  4. The International Linear Collider

    CERN Document Server

    Barish, Barry

    2013-01-01

    In this article, we describe the key features of the recently completed technical design for the International Linear Collider (ILC), a 200-500 GeV linear electron-positron collider (expandable to 1 TeV) that is based on 1.3 GHz superconducting radio-frequency (SCRF) technology. The machine parameters and detector characteristics have been chosen to complement the Large Hadron Collider physics, including the discovery of the Higgs boson, and to further exploit this new particle physics energy frontier with a precision instrument. The linear collider design is the result of nearly twenty years of R&D, resulting in a mature conceptual design for the ILC project that reflects an international consensus. We summarize the physics goals and capability of the ILC, the enabling R&D and resulting accelerator design, as well as the concepts for two complementary detectors. The ILC is technically ready to be proposed and built as a next generation lepton collider, perhaps to be built in stages beginning as a Hig...

  5. Firey linear combinations of convex bodies

    Institute of Scientific and Technical Information of China (English)

    XIONG Ge; XIAO Qi-ming; CHEUNG Wing-Sum

    2009-01-01

    For convex bodies, the Firey linear combinations were introduced and studied in several papers. In this paper the mean width of the Firey linear combinations of convex bodies is studied, and the lower bound of the mean width of the Firey linear combinations of convex body and its polar body is given.

  6. A linear combination of modified Bessel functions

    Science.gov (United States)

    Shitzer, A.; Chato, J. C.

    1971-01-01

    A linear combination of modified Bessel functions is defined, discussed briefly, and tabulated. This combination was found to recur in the analysis of various heat transfer problems and in the analysis of the thermal behavior of living tissue when modeled by cylindrical shells.

  7. Physics Case for the International Linear Collider

    CERN Document Server

    Fujii, Keisuke; Peskin, Michael E; Barklow, Tim; Gao, Yuanning; Kanemura, Shinya; Kim, Hyungdo; List, Jenny; Nojiri, Mihoko; Perelstein, Maxim; Poeschl, Roman; Reuter, Juergen; Simon, Frank; Tanabe, Tomohiko; Yu, Jaehoon; Wells, James D; Murayama, Hitoshi; Yamamoto, Hitoshi

    2015-01-01

    We summarize the physics case for the International Linear Collider (ILC). We review the key motivations for the ILC presented in the literature, updating the projected measurement uncertainties for the ILC experiments in accord with the expected schedule of operation of the accelerator and the results of the most recent simulation studies.

  8. Physics Case for the International Linear Collider

    Energy Technology Data Exchange (ETDEWEB)

    Fujii, Keisuke; /KEK, Tsukuba; Grojean, Christophe; /DESY /ICREA, Barcelona; Peskin, Michael E.; Barklow, Tim; /SLAC; Gao, Yuanning; /Tsinghua U., Beijing, CHEP; Kanemura, Shinya; /Toyama U.; Kim, Hyungdo; /Seoul Natl U.; List, Jenny; /DESY; Nojiri, Mihoko; /KEK, Tsukuba; Perelstein, Maxim; /Cornell U., LEPP; Poeschl, Roman; /LAL, Orsay; Reuter, Juergen; /DESY; Simon, Frank; /Munich, Max Planck Inst.; Tanabe, Tomohiko; /Tokyo U., ICEPP; Yu, Jaehoon; /Texas U., Arlington; Wells, James D.; /Michigan U., MCTP; Murayama, Hitoshi; /UC, Berkeley /LBNL /Tokyo U., IPMU; Yamamoto, Hitoshi; /Tohoku U.

    2015-06-23

    We summarize the physics case for the International Linear Collider (ILC). We review the key motivations for the ILC presented in the literature, updating the projected measurement uncertainties for the ILC experiments in accord with the expected schedule of operation of the accelerator and the results of the most recent simulation studies.

  9. Features in visual search combine linearly.

    Science.gov (United States)

    Pramod, R T; Arun, S P

    2014-04-08

    Single features such as line orientation and length are known to guide visual search, but relatively little is known about how multiple features combine in search. To address this question, we investigated how search for targets differing in multiple features (intensity, length, orientation) from the distracters is related to searches for targets differing in each of the individual features. We tested race models (based on reaction times) and co-activation models (based on reciprocal of reaction times) for their ability to predict multiple feature searches. Multiple feature searches were best accounted for by a co-activation model in which feature information combined linearly (r = 0.95). This result agrees with the classic finding that these features are separable i.e., subjective dissimilarity ratings sum linearly. We then replicated the classical finding that the length and width of a rectangle are integral features-in other words, they combine nonlinearly in visual search. However, to our surprise, upon including aspect ratio as an additional feature, length and width combined linearly and this model outperformed all other models. Thus, length and width of a rectangle became separable when considered together with aspect ratio. This finding predicts that searches involving shapes with identical aspect ratio should be more difficult than searches where shapes differ in aspect ratio. We confirmed this prediction on a variety of shapes. We conclude that features in visual search co-activate linearly and demonstrate for the first time that aspect ratio is a novel feature that guides visual search.

  10. Seventh International Accelerator School for Linear Colliders

    CERN Document Server

    Organizers of the Seventh International Accelerator School for Linear Colliders

    2012-01-01

    We are pleased to announce the Seventh International Accelerator School for Linear Colliders. This school is a continuation of the series of schools which began six years ago.  The first school was held in 2006 in Sokendai, Japan, the second in 2007 in Erice, Italy, the third in 2008 in Oakbrook Hills, USA, the fourth in 2009 in Huairou, China, the fifth in 2010 in Villars-sur-Ollon, Switzerland, and the sixth in 2011 in Pacific Grove, USA.   The school is organized by the International Linear Collider (ILC) Global Design Effort (GDE), the Compact Linear Collider (CLIC) and the International Committee for Future Accelerators (ICFA) Beam Dynamics Panel. The school this year will take place at the Radisson Blu Hotel, Indore, India from November 27 to December 8, 2012. It is hosted by the Raja Ramanna Center for Advanced Technology (RRCAT) and sponsored by a number of funding agencies and institutions around the world including the U.S. Department of Energy (DOE), the U.S. National Science...

  11. Mode Combinations and International Operations

    DEFF Research Database (Denmark)

    Benito, Gabriel R. G.; Petersen, Bent; Welch, Lawrence S.

    2011-01-01

    reveals that companies tend to combine modes of operation; thereby producing unique foreign operation mode “packages” for given activities and/or countries, and that the packages are liable to be modified over time – providing a potentially important optional path for international expansion. Our data...

  12. Mode Combinations and International Operations

    DEFF Research Database (Denmark)

    Benito, Gabriel R. G.; Petersen, Bent; Welch, Lawrence S.

    2011-01-01

    reveals that companies tend to combine modes of operation; thereby producing unique foreign operation mode “packages” for given activities and/or countries, and that the packages are liable to be modified over time—providing a potentially important optional path for international expansion. The data show...

  13. Inpainting with sparse linear combinations of exemplars

    Energy Technology Data Exchange (ETDEWEB)

    Wohlberg, Brendt [Los Alamos National Laboratory

    2008-01-01

    We introduce a new exemplar-based inpainting algorithm based on representing the region to be inpainted as a sparse linear combination of blocks extracted from similar parts of the image being inpainted. This method is conceptually simple, being computed by functional minimization, and avoids the complexity of correctly ordering the filling in of missing regions of other exemplar-based methods. Initial performance comparisons on small inpainting regions indicate that this method provides similar or better performance than other recent methods.

  14. Broader Impacts of the International Linear Collider

    Energy Technology Data Exchange (ETDEWEB)

    Bardeen, M.; Ruchti, R.

    2005-08-01

    Large-scale scientific endeavors such as the International Linear Collider Project can have a lasting impact on education and outreach to our society. The ILC will provide a discovery platform for frontier physical science and it will also provide a discovery platform for broader impacts and social science. The importance of Broader Impacts of Science in general and the ILC in particular are described. Additionally, a synopsis of education and outreach activities carried out as an integral part of the Snowmass ILC Workshop is provided.

  15. Broader Impacts of the International Linear Collider

    Energy Technology Data Exchange (ETDEWEB)

    Bardeen, M.; Ruchti, R.

    2005-08-01

    Large-scale scientific endeavors such as the International Linear Collider Project can have a lasting impact on education and outreach to our society. The ILC will provide a discovery platform for frontier physical science and it will also provide a discovery platform for broader impacts and social science. The importance of Broader Impacts of Science in general and the ILC in particular are described. Additionally, a synopsis of education and outreach activities carried out as an integral part of the Snowmass ILC Workshop is provided.

  16. Sixth international workshop on linear colliders. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Urakawa, Junji [ed.

    1995-08-01

    The sixth international workshop on linear colliders (LC95) was held by KEK at Tsukuba Center for Institute. In the workshop 8 parallel working group were organized: WG1 (beam sources and injection linacs), WG2 (damping rings and bunch compressors), WG3 (a: RF sources and structures, b: superconducting cavities, c: two beam accelerators), WG4 (beam dynamics in main linacs), WG5 (final focus and integration regions), WG6 (beam instrumentation), WG7 (overall parameters and construction techniques), WG8 (gamma-gamma collider and miscellaneous). This issue compiles materials which were used in the workshop. (J.P.N.).

  17. Precision Physics at the International Linear Collider

    Energy Technology Data Exchange (ETDEWEB)

    Heuer, R.-D. [Institut fuer Experimentalphysik, Hamburg University, Hamburg (Germany)

    2006-10-15

    Despite the great success of the Standard Model, many key questions in particle physics and cosmology are unanswered today. Together with the Large Hadron Collider LHC, starting in 2007, the International Linear Collider ILC as the next project planned at the high energy frontier, will play a crucial role in tackling many of these most exciting questions. The high precision achievable with experiments at the ILC will be indispensable in order to reach definite conclusions about many features of new physics expected at the TeV scale. This contribution presents prominent physics examples and describes detector challenges and the project status.

  18. Governance of the International Linear Collider Project

    Energy Technology Data Exchange (ETDEWEB)

    Foster, B.; /Oxford U.; Barish, B.; /Caltech; Delahaye, J.P.; /CERN; Dosselli, U.; /INFN, Padua; Elsen, E.; /DESY; Harrison, M.; /Brookhaven; Mnich, J.; /DESY; Paterson, J.M.; /SLAC; Richard, F.; /Orsay, LAL; Stapnes, S.; /CERN; Suzuki, A.; /KEK, Tsukuba; Wormser, G.; /Orsay, LAL; Yamada, S.; /KEK, Tsukuba

    2012-05-31

    Governance models for the International Linear Collider Project are examined in the light of experience from similar international projects around the world. Recommendations for one path which could be followed to realize the ILC successfully are outlined. The International Linear Collider (ILC) is a unique endeavour in particle physics; fully international from the outset, it has no 'host laboratory' to provide infrastructure and support. The realization of this project therefore presents unique challenges, in scientific, technical and political arenas. This document outlines the main questions that need to be answered if the ILC is to become a reality. It describes the methodology used to harness the wisdom displayed and lessons learned from current and previous large international projects. From this basis, it suggests both general principles and outlines a specific model to realize the ILC. It recognizes that there is no unique model for such a laboratory and that there are often several solutions to a particular problem. Nevertheless it proposes concrete solutions that the authors believe are currently the best choices in order to stimulate discussion and catalyze proposals as to how to bring the ILC project to fruition. The ILC Laboratory would be set up by international treaty and be governed by a strong Council to whom a Director General and an associated Directorate would report. Council would empower the Director General to give strong management to the project. It would take its decisions in a timely manner, giving appropriate weight to the financial contributions of the member states. The ILC Laboratory would be set up for a fixed term, capable of extension by agreement of all the partners. The construction of the machine would be based on a Work Breakdown Structure and value engineering and would have a common cash fund sufficiently large to allow the management flexibility to optimize the project's construction. Appropriate contingency

  19. International linear collider reference design report

    Energy Technology Data Exchange (ETDEWEB)

    Aarons, G.

    2007-06-22

    The International Linear Collider will give physicists a new cosmic doorway to explore energy regimes beyond the reach of today's accelerators. A proposed electron-positron collider, the ILC will complement the Large Hadron Collider, a proton-proton collider at the European Center for Nuclear Research (CERN) in Geneva, Switzerland, together unlocking some of the deepest mysteries in the universe. With LHC discoveries pointing the way, the ILC -- a true precision machine -- will provide the missing pieces of the puzzle. Consisting of two linear accelerators that face each other, the ILC will hurl some 10 billion electrons and their anti-particles, positrons, toward each other at nearly the speed of light. Superconducting accelerator cavities operating at temperatures near absolute zero give the particles more and more energy until they smash in a blazing crossfire at the centre of the machine. Stretching approximately 35 kilometres in length, the beams collide 14,000 times every second at extremely high energies -- 500 billion-electron-volts (GeV). Each spectacular collision creates an array of new particles that could answer some of the most fundamental questions of all time. The current baseline design allows for an upgrade to a 50-kilometre, 1 trillion-electron-volt (TeV) machine during the second stage of the project. This reference design provides the first detailed technical snapshot of the proposed future electron-positron collider, defining in detail the technical parameters and components that make up each section of the 31-kilometer long accelerator. The report will guide the development of the worldwide R&D program, motivate international industrial studies and serve as the basis for the final engineering design needed to make an official project proposal later this decade.

  20. The International Linear Collider - Physics and Perspectives

    CERN Document Server

    ,

    2016-01-01

    With the discovery of a Higgs boson at LHC, all particles of the Standard Model seem to have been observed experimentally, yet many questions are left unanswered. The discovery has intensified the planning for future high-energy colliders, which aim to probe the Standard Model and the mechanism of electroweak symmetry breaking with higher precision and to extend and complement the search for new particles currently under way at the LHC. The most mature option for such a future facility is the International Linear Collider ILC, an electron-positron collider with a centre-of-mass energy of 500 GeV, and the potential for upgrades into the TeV region. The ILC will fully explore the Higgs sector, including model-independent coupling and width measurements, direct measurements of the coupling to the top quark and the Higgs self-coupling, enable precision measurements of top quark properties and couplings as well as other electroweak precision measurements and provide extensive discovery potential for new physics co...

  1. Linear combinations come alive in crossover designs.

    Science.gov (United States)

    Shuster, Jonathan J

    2017-10-30

    Before learning anything about statistical inference in beginning service courses in biostatistics, students learn how to calculate the mean and variance of linear combinations of random variables. Practical precalculus examples of the importance of these exercises can be helpful for instructors, the target audience of this paper. We shall present applications to the "1-sample" and "2-sample" methods for randomized short-term 2-treatment crossover studies, where patients experience both treatments in random order with a "washout" between the active treatment periods. First, we show that the 2-sample method is preferred as it eliminates "conditional bias" when sample sizes by order differ and produces a smaller variance. We also demonstrate that it is usually advisable to use the differences in posttests (ignoring baseline and post washout values) rather than the differences between the changes in treatment from the start of the period to the end of the period ("delta of delta"). Although the intent is not to provide a definitive discussion of crossover designs, we provide a section and references to excellent alternative methods, where instructors can provide motivation to students to explore the topic in greater detail in future readings or courses. Copyright © 2017 John Wiley & Sons, Ltd.

  2. Least Square Approximation by Linear Combinations of Multi(Poles).

    Science.gov (United States)

    1983-04-01

    ID-R134 069 LEAST SQUARE APPROXIMATION BY LINEAR COMBINATIONS OF i/i MULTI(POLES). 1U OHIO STATE UNIV COLUMBUS DEPT OF GEODETIC SCIENCE AND SURVEY...TR-83-0 117 LEAST SQUARE APPROXIMATION BY LINEAR COMBINATIONS OF (MULTI)POLES WILLI FREEDEN DEPARTMENT OF GEODETIC SCIENCE AND SURVEYING THE OHIO...Subtitle) S. TYPE OF REPORT & PERIOD COVERED LEAST SQUARE APPROXIMATION BY LINEAR Scientific Report No. 3 COMBINATIONS OF (MULTI)POLES 6. PERFORMING ORG

  3. Neural Network for Combining Linear and Non-Linear Modelling of Dynamic Systems

    DEFF Research Database (Denmark)

    Madsen, Per Printz

    1994-01-01

    The purpose of this paper is to develop a method to combine linear models with MLP networks. In other words to find a method to make a non-linear and multivariable model that performs at least as good as a linear model, when the training data lacks information.......The purpose of this paper is to develop a method to combine linear models with MLP networks. In other words to find a method to make a non-linear and multivariable model that performs at least as good as a linear model, when the training data lacks information....

  4. The SiD Detector for the International Linear Collider

    CERN Document Server

    ,

    2015-01-01

    The SiD Detector is one of two validated detector designs for the future International Linear Collider. SiD features a compact, cost-constrained design for precision Higgs couplings determination, and other measurements, and sensitivity to a wide range of possible new phenomena. A robust silicon vertex and tracking system, combined with a 5 Tesla central solenoidal field, provides excellent momentum resolution. The highly granular calorimeter system is optimized for Particle Flow application to achieve very good jet energy resolution over a wide range of energies. Details of the proposed implementation of the SiD subsystems, as driven by the physics requirements, will be given. The shared interaction point, push-pull mechanism, will be described, together with the estimated timeline for construction.

  5. Successful combination of the stochastic linearization and Monte Carlo methods

    Science.gov (United States)

    Elishakoff, I.; Colombi, P.

    1993-01-01

    A combination of a stochastic linearization and Monte Carlo techniques is presented for the first time in literature. A system with separable nonlinear damping and nonlinear restoring force is considered. The proposed combination of the energy-wise linearization with the Monte Carlo method yields an error under 5 percent, which corresponds to the error reduction associated with the conventional stochastic linearization by a factor of 4.6.

  6. NICADD scientists develop detector technology for International Linear Collider

    CERN Multimedia

    2006-01-01

    "Scientist at the Northern Illinois Center for Accelerator and Detector Development (NICADD) are celebrating the successful run of a prototype subdetector for the proposed International Linear Collider (ILC)." (1 page)

  7. Linear combination of forecasts with numerical adjustment via MINIMAX non-linear programming

    Directory of Open Access Journals (Sweden)

    Jairo Marlon Corrêa

    2016-03-01

    Full Text Available This paper proposes a linear combination of forecasts obtained from three forecasting methods (namely, ARIMA, Exponential Smoothing and Artificial Neural Networks whose adaptive weights are determined via a multi-objective non-linear programming problem, which seeks to minimize, simultaneously, the statistics: MAE, MAPE and MSE. The results achieved by the proposed combination are compared with the traditional approach of linear combinations of forecasts, where the optimum adaptive weights are determined only by minimizing the MSE; with the combination method by arithmetic mean; and with individual methods

  8. On the Linear Combination of Exponential and Gamma Random Variables

    Directory of Open Access Journals (Sweden)

    Samuel Kotz

    2005-06-01

    Full Text Available Abstract: The exact distribution of the linear combination α X + β Y is derived when X and Y are exponential and gamma random variables distributed independently of each other. A measure of entropy of the linear combination is investigated. We also provide computer programs for generating tabulations of the percentage points associated with the linear combination. The work is motivated by examples in automation, control, fuzzy sets, neurocomputing and other areas of computer science.

  9. The Optimal Linear Combination of Multiple Predictors Under the Generalized Linear Models.

    Science.gov (United States)

    Jin, Hua; Lu, Ying

    2009-11-15

    Multiple alternative diagnostic tests for one disease are commonly available to clinicians. It's important to use all the good diagnostic predictors simultaneously to establish a new predictor with higher statistical utility. Under the generalized linear model for binary outcomes, the linear combination of multiple predictors in the link function is proved optimal in the sense that the area under the receiver operating characteristic (ROC) curve of this combination is the largest among all possible linear combination. The result was applied to analysis of the data from the Study of Osteoporotic Fractures (SOF) with comparison to Su and Liu's approach.

  10. Klystron switching power supplies for the Internation Linear Collider

    Energy Technology Data Exchange (ETDEWEB)

    Fraioli, Andrea; /Cassino U. /INFN, Pisa

    2009-12-01

    The International Linear Collider is a majestic High Energy Physics particle accelerator that will give physicists a new cosmic doorway to explore energy regimes beyond the reach of today's accelerators. ILC will complement the Large Hadron Collider (LHC), a proton-proton collider at the European Center for Nuclear Research (CERN) in Geneva, Switzerland, by producing electron-positron collisions at center of mass energy of about 500 GeV. In particular, the subject of this dissertation is the R&D for a solid state Marx Modulator and relative switching power supply for the International Linear Collider Main LINAC Radio Frequency stations.

  11. Combined forecasts from linear and nonlinear time series models

    NARCIS (Netherlands)

    N. Terui (Nobuhiko); H.K. van Dijk (Herman)

    1999-01-01

    textabstractCombined forecasts from a linear and a nonlinear model are investigated for time series with possibly nonlinear characteristics. The forecasts are combined by a constant coefficient regression method as well as a time varying method. The time varying method allows for a locally (non)line

  12. SOLUTION OF A KIND OF LINEAR INTERNAL WAVE EQUATION

    Institute of Scientific and Technical Information of China (English)

    WANG Gang; HOU Yi-jun; ZHENG Quan-an

    2005-01-01

    Considering the effect of horizontal Coriolis parameter and the density compactness of seawater, which were often neglected in internal waves discussion, the governing equation of linear internal waves presented by vertical velocity only will be proposed. Under the assumption that the Brunt-Visl frequency is exponential, an accurate analytic solution of it is obtained. Finally, the expressions of wave functions are also given.

  13. The Higgs Physics Programme at the International Linear Collider

    CERN Document Server

    Sefkow, Felix

    2014-01-01

    The talk summarises the case for Higgs physics in $e^+e^-$ collisions and explains how Higgs parameters can be extracted in a model-independent way at the International Linear Collider (ILC). The expected precision will be discussed in the context of projections for the experiments at the Large Hadron Collider (LHC).

  14. Teilchenphysik: Auf dem Weg zum International Linear Collider

    Science.gov (United States)

    Elsen, Eckhard

    2006-07-01

    Führende Beschleuniger- und Teilchenphysiker in Amerika, Asien und Europa arbeiten gemeinsam an der Planung des International Linear Collider (ILC). In dieser etwa 30 Kilometer langen Maschine werden Elektronen und Positronen beschleunigt und mit bisher unerreicht hohen Energien aufeinander prallen. Die Wissenschaftler erwarten davon Einblicke in die Welt jenseits des Standardmodells.

  15. Signals of universal extra dimension at the international linear collider

    Indian Academy of Sciences (India)

    Biplob Bhattacherjee

    2007-11-01

    In the minimal universal extra dimension model, single production of = 2 gauge bosons provides a unique discriminating feature from supersymmetry. We discuss how the proposed international linear collider can act as a = 2 factory, much in the same vein as LEP.

  16. The possibilities of linearized inversion of internally scattered seismic data

    KAUST Repository

    Aldawood, Ali

    2014-08-05

    Least-square migration is an iterative linearized inversion scheme that tends to suppress the migration artifacts and enhance the spatial resolution of the migrated image. However, standard least-square migration, based on imaging single scattering energy, may not be able to enhance events that are mainly illuminated by internal multiples such as vertical and nearly vertical faults. To alleviate this problem, we propose a linearized inversion framework to migrate internally multiply scattered energy. We applied this least-square migration of internal multiples to image a vertical fault. Tests on synthetic data demonstrate the ability of the proposed method to resolve a vertical fault plane that is poorly resolved by least-square imaging using primaries only. We, also, demonstrate the robustness of the proposed scheme in the presence of white Gaussian random observational noise and in the case of imaging the fault plane using inaccurate migration velocities.

  17. Reactive Scattering Wave Functions by Linear Combination of Arrangement Channels

    Institute of Scientific and Technical Information of China (English)

    邓从豪; 冯大诚; 蔡政亭

    1994-01-01

    The similarity and dissimilarity of reactive scattering wave functions and molecular orbitalby linear combination of atomic orbitals(LCAOMO)are examined.Based on the similarity a method is pro-posed to construct the reactive scattering wave functions by linear combination of arrangement channel wavefunctions(LCACSW).Based on the dissimilarity,it is shown that the combination coefficients can be deter-mined by solving s set of simultaneous algebraic equations.The elements of the reactive scattering matrix areshown to be related to the combination coefficients of open arrangement channels.The differential and totalreactive scattering cross-section derived by this method agrees completely with that derived by other meth-ods.

  18. Numerical calculation of dispersion relation for linear internal waves

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    With the horizontal Coriolis terms included in motion equations and the influence of compressibility of seawater on Brunt-V(a)is(a)l(a) frequency considered, a numerical method of calculating the dispersion relation for linear internal waves, which is an improvement of Cai and Gan (1995), and hence Fliegel and Hunkins (1975), had been set up. For different models (Pacific model, Atlantic model and Arctic model), simulations using the three different methods were compared and the following conclusions were reached: (1) the influence of horizontal Coriolis terms on dispersion relation cannot be neglected and is connected with the direction of the wave celerity, the latitude, and the modes of the wave;(2) the effect of compressibility of seawater in stratification is not an important factor for the dispersion relation of linear internal wave, at least for those three models. With the improved method, the wavefunction curves for the Pacific model had also been built.

  19. The Higgs boson and the International Linear Collider

    Directory of Open Access Journals (Sweden)

    Francesca eBorzumati

    2014-06-01

    Full Text Available The Higgs boson will be subject of intense experimental searches in future high-energy experiments. In addition to the e□ort made at the Large Hadron Collider, where it was discovered, it will be the major subject of study at the International Linear Collider. We review here the reasons for that and some of the issues to be tackled at this future accelerator.

  20. Linearized least-square imaging of internally scattered data

    KAUST Repository

    Aldawood, Ali

    2014-01-01

    Internal multiples deteriorate the quality of the migrated image obtained conventionally by imaging single scattering energy. However, imaging internal multiples properly has the potential to enhance the migrated image because they illuminate zones in the subsurface that are poorly illuminated by single-scattering energy such as nearly vertical faults. Standard migration of these multiples provide subsurface reflectivity distributions with low spatial resolution and migration artifacts due to the limited recording aperture, coarse sources and receivers sampling, and the band-limited nature of the source wavelet. Hence, we apply a linearized least-square inversion scheme to mitigate the effect of the migration artifacts, enhance the spatial resolution, and provide more accurate amplitude information when imaging internal multiples. Application to synthetic data demonstrated the effectiveness of the proposed inversion in imaging a reflector that is poorly illuminated by single-scattering energy. The least-square inversion of doublescattered data helped delineate that reflector with minimal acquisition fingerprint.

  1. The International Linear Collider: An R&D Progress Report

    CERN Document Server

    Harrison, Mike; Ross, Marc; Royole-Degieux, Perrine; Takahashi, Rika; Walker, Nicholas; Warmbein, Barbara; Yamamoto, Akira; Yokoya, Kaoru; Zhang, Min; Elsen, Eckhard

    2011-01-01

    The International Linear Collider: An R&D Progress Report marks the halfway point towards the Global Design Effort fulfilling its mandate to follow up the ILC Reference Design Report with a more optimised Technical Design Report (TDR) by the end of 2012. The TDR will be based on much of the work reported here and will contain all the elements needed to propose the ILC to collaborating governments, including a technical design and implementation plan that are realistic and have been better optimised for performance, cost and risk.

  2. International Linear Collider Technical Review Committee: Second Report, 2003

    Energy Technology Data Exchange (ETDEWEB)

    Loew, Gregory

    2003-02-21

    As this report is being published, the international high energy physics (HEP) community finds itself confronting a set of fascinating discoveries and new questions regarding the nature of matter and its fundamental particles and forces. The observation of neutrino oscillations that indicates that neutrinos have mass, measurements of the accelerating expansion of the universe that may be due to dark energy, and evidence for a period of rapid inflation at the beginning of the Big Bang are stimulating the entire field. Looming on the horizon are the potential discoveries of a Higgs particle that may reveal the origin of mass and of a whole family of supersymmetric particles that may be part of the cosmic dark matter. For the HEP community to elucidate these mysteries, new accelerators are indispensable. At this time, after careful deliberations, all three regional organizations of the HEP community (ACFA in Asia, HEPAP in North America, and ECFA in Europe) have reached the common conclusion that the next accelerator should be an electron-positron linear collider with an initial center-of-mass energy of 500 Giga-electronvolts (GeV), later upgradable to higher energies, and that it should be built and operated in parallel with the Large Hadron Collider under construction at CERN. Hence, this second report of the International Linear Collider Technical Review Committee (ILC-TRC) comes at a very timely moment. The report was requested by the International Committee on Future Accelerators (ICFA) in February 2001 to assess the current technical status of electron-positron linear collider designs in the various regions. Note that the ILC-TRC was not asked to concern itself with either cost studies or the ultimate selection process of a machine. This Executive Summary gives a short outline of the genesis of the report, the charge given to the committee, and its organization. It then presents a brief description of four electron-positron linear collider designs at hand. The

  3. Linear Collider Flavour Identification status report: Sensors for the International Linear Collider

    Indian Academy of Sciences (India)

    K D Stefanov; for the Linear Collider Flavour Identification (LCFI) Collaboration

    2007-12-01

    The Linear Collider Flavour Identification (LCFI) collaboration is continuing the work to develop column-parallel CCDs (CPCCD) and CMOS readout chips to be used in the vertex detector at the international linear collider (ILC). The CPCCD achieves several orders of magnitude faster readout than conventional CCDs because every column is equipped with amplifier and ADC, enabling efficient data taking with low occupancy. Already two generations of CPCCDs and readout chips have been manufactured and the first chips have been fully tested. The second generation devices are now being evaluated. A new CCD-based device, the in-situ storage image sensor (ISIS) has also been developed. The ISIS offers numerous advantages in terms of relaxed readout, increased radiation hardness and great immunity to EMI. In this paper we present the results from the tests of the CPCCDs, readout chips and ISIS, as well as the plans for future developments.

  4. 9th International Accelerator School for Linear Colliders

    CERN Document Server

    2015-01-01

    This school is a continuation of the series of schools that began nine years ago: Japan 2006, Italy 2007, United States 2008, China 2009, Switzerland 2010, United States 2011, India 2012 and Turkey 2013. Based on needs from the accelerator community, the Linear Collider Collaboration (LCC) and ICFA Beam Dynamics Panel are organising the Ninth International Accelerator School for Linear Colliders. The school will present instruction in TeV-scale linear colliders including the ILC, CLIC and other advanced accelerators. An important change of this year’s school from previous LC schools is that it will also include the free electron laser (FEL), a natural extension for applications of the ILC/CLIC technology. The school is offered to graduate students, postdoctoral fellows and junior researchers from around the world. We welcome applications from physicists who are considering changing to a career in accelerator physics and technology. This school adopts an in depth approach. A selective course on the FEL has b...

  5. Combined generating-accelerating buncher for compact linear accelerators

    Science.gov (United States)

    Savin, E. A.; Matsievskiy, S. V.; Sobenin, N. P.; Sokolov, I. D.; Zavadtsev, A. A.

    2016-09-01

    Described in the previous article [1] method of the power extraction from the modulated electron beam has been applied to the compact standing wave electron linear accelerator feeding system, which doesnt require any connection waveguides between the power source and the accelerator itself [2]. Generating and accelerating bunches meet in the hybrid accelerating cell operating at TM020 mode, thus the accelerating module is placed on the axis of the generating module, which consists from the pulsed high voltage electron sources and electrons dumps. This combination makes the accelerator very compact in size which is very valuable for the modern applications such as portable inspection sources. Simulations and geometry cold tests are presented.

  6. Considerations on some neglected but impotant issues concerning the In ternal Linear Combination method in Astronomy

    CERN Document Server

    Vio, R

    2009-01-01

    Although the ``internal linear'' combination method (ILC) is a technique widely used for the separation of the Cosmic Microwave Background signal from the Galactic foregrounds, its characteristics are not yet well defined. This can lead to misleading conclusions about the actual potentialities and limits of such approach in real applications. Here we discuss briefly some facts about ILC that to our knowledge are not fully worked out in literature and yet have deep effects in the interpretation of the results.

  7. A conventional positron source for International Linear Collider

    CERN Document Server

    Gai, Wei; Kawada, Shin-ichi; Liu, Wanming; Okuda, Natsuki; Omori, Tsunehiko; Pei, Guoxi; Riemann, Sabine; Takahashi, Tohru; Urakawa, Junji; Ushakov, Andriy

    2011-01-01

    A possible solution to realize a conventional positron source driven by a several-GeV electron beam for the International Linear Collider is proposed. A 300 Hz electron linac is employed to create positrons with stretching pulse length in order to cure target thermal load. ILC requires about 2600 bunches in a train which pulse length is 1 ms. Each pulse of the 300 Hz linac creates about 130 bunches, then 2600 bunches are created in 63 ms. Optimized parameters such as drive beam energy, beam size, and target thickness, are discussed assuming a L-band capture system to maximize the capture efficiency and to mitigate the target thermal load. A slow rotating tungsten disk is employed as positron generation target.

  8. Double vector meson production in the International Linear Collider

    Energy Technology Data Exchange (ETDEWEB)

    Carvalho, F. [Universidade Federal de Sao Paulo, Departamento de Ciencias Exatas e da Terra, Diadema, SP (Brazil); Goncalves, V.P. [Universidade Federal de Pelotas, High and Medium Energy Group, Instituto de Fisica e Matematica, Caixa Postal 354, Pelotas, RS (Brazil); Moreira, B.D.; Navarra, F.S. [Universidade de Sao Paulo, Instituto de Fisica, C.P. 66318, Sao Paulo, SP (Brazil)

    2015-08-15

    In this paper we study double vector meson production in γγ interactions at high energies and estimate, using the color dipole picture, the main observables which can be probed at the International Linear Collider (ILC). The total γ(Q{sub 1}{sup 2}) + γ(Q{sub 2}{sup 2}) → V{sub 1} + V{sub 2} cross sections for V{sub i} = ρ, J/ψ, and Υ are computed and the energy and virtuality dependencies are studied in detail. Our results demonstrate that the experimental analysis of this process is feasible at the ILC and it can be useful to constrain the QCD dynamics at high energies. (orig.)

  9. Characterization of the International Linear Collider damping ring optics

    CERN Document Server

    Shanks, James; Sagan, David

    2013-01-01

    A method is presented for characterizing the emittance dilution and dynamic aperture for an arbitrary closed lattice that includes guide field magnet errors, multipole errors and misalignments. This method, developed and tested at CesrTA, has been applied to the damping ring lattice for the International Linear Collider (ILC). The effectiveness of beam based emittance tuning is limited by beam position monitor (BPM) measurement errors, disposition of corrector magnets, and tuning algorithm. The specifications for damping ring magnet alignment, multipoles, and number and precision of the BPMs are shown to be consistent with the required emittances and dynamic aperture. Further analysis of the ILC damping ring lattice demonstrates the implications of reducing the number of BPMs and relaxing the constraints on guide field multipoles.

  10. The International Linear Collider Technical Design Report - Volume 4: Detectors

    CERN Document Server

    Behnke, Ties; Burrows, Philip N.; Fuster, Juan; Peskin, Michael; Stanitzki, Marcel; Sugimoto, Yasuhiro; Yamada, Sakue; Yamamoto, Hitoshi

    2013-01-01

    The International Linear Collider Technical Design Report (TDR) describes in four volumes the physics case and the design of a 500 GeV centre-of-mass energy linear electron-positron collider based on superconducting radio-frequency technology using Niobium cavities as the accelerating structures. The accelerator can be extended to 1 TeV and also run as a Higgs factory at around 250 GeV and on the Z0 pole. A comprehensive value estimate of the accelerator is give, together with associated uncertainties. It is shown that no significant technical issues remain to be solved. Once a site is selected and the necessary site-dependent engineering is carried out, construction can begin immediately. The TDR also gives baseline documentation for two high-performance detectors that can share the ILC luminosity by being moved into and out of the beam line in a "push-pull" configuration. These detectors, ILD and SiD, are described in detail. They form the basis for a world-class experimental programme that promises to incr...

  11. The International Linear Collider Technical Design Report - Volume 2: Physics

    CERN Document Server

    Barklow, Tim; Fujii, Keisuke; Gao, Yuanning; Hoang, Andre; Kanemura, Shinya; List, Jenny; Logan, Heather E; Nomerotski, Andrei; Perelstein, Maxim; Peskin, Michael E; Pöschl, Roman; Reuter, Jürgen; Riemann, Sabine; Savoy-Navarro, Aurore; Servant, Geraldine; Tait, Tim M P

    2013-01-01

    The International Linear Collider Technical Design Report (TDR) describes in four volumes the physics case and the design of a 500 GeV centre-of-mass energy linear electron-positron collider based on superconducting radio-frequency technology using Niobium cavities as the accelerating structures. The accelerator can be extended to 1 TeV and also run as a Higgs factory at around 250 GeV and on the Z0 pole. A comprehensive value estimate of the accelerator is give, together with associated uncertainties. It is shown that no significant technical issues remain to be solved. Once a site is selected and the necessary site-dependent engineering is carried out, construction can begin immediately. The TDR also gives baseline documentation for two high-performance detectors that can share the ILC luminosity by being moved into and out of the beam line in a "push-pull" configuration. These detectors, ILD and SiD, are described in detail. They form the basis for a world-class experimental programme that promises to incr...

  12. The International Linear Collider Technical Design Report - Volume 4: Detectors

    Energy Technology Data Exchange (ETDEWEB)

    Behnke, Ties [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States)

    2013-06-26

    The International Linear Collider Technical Design Report (TDR) describes in four volumes the physics case and the design of a 500 GeV centre-of-mass energy linear electron-positron collider based on superconducting radio-frequency technology using Niobium cavities as the accelerating structures. The accelerator can be extended to 1 TeV and also run as a Higgs factory at around 250 GeV and on the Z0 pole. A comprehensive value estimate of the accelerator is give, together with associated uncertainties. It is shown that no significant technical issues remain to be solved. Once a site is selected and the necessary site-dependent engineering is carried out, construction can begin immediately. The TDR also gives baseline documentation for two high-performance detectors that can share the ILC luminosity by being moved into and out of the beam line in a "push-pull" configuration. These detectors, ILD and SiD, are described in detail. They form the basis for a world-class experimental programme that promises to increase significantly our understanding of the fundamental processes that govern the evolution of the Universe.

  13. The International Linear Collider Technical Design Report - Volume 2: Physics

    Energy Technology Data Exchange (ETDEWEB)

    Baer, Howard [Univ. of Oklahoma, Norman, OK (United States); Barklow, Tim [SLAC National Accelerator Lab., Menlo Park, CA (United States); Fujii, Keisuke [National Lab. for High Energy Physics (KEK), Tokai (Japan); Gao, Yuanning [Unlisted; Hoang, Andre [Univ. of Vienna (Austria); Kanemura, Shinya [Univ. of Toyama (Japan); List, Jenny [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Logan, Heather E. [Carleton Univ., Ottawa, ON (Canada); Nomerotski, Andrei [Univ. of Oxford (United Kingdom); Perelstein, Maxim [Cornell Univ., Ithaca, NY (United States); Peskin, Michael E. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Pöschl, Roman [Univ. Paris-Sud, Orsay (France). Linear Accelerator Lab. (LAL); Reuter, Jürgen [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Riemann, Sabine [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Savoy-Navarro, Aurore [CNRS/IN2P3. Univ. Paris (France). Observatoire de Paris. AstroParticule et Cosmologie (APC); Servant, Geraldine [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Tait, Tim P. [Univ. of California, Los Angeles, CA (United States); Yu, Jaehoon [Univ. of Science and Technology of China, Hefei (China)

    2013-06-26

    The International Linear Collider Technical Design Report (TDR) describes in four volumes the physics case and the design of a 500 GeV centre-of-mass energy linear electron-positron collider based on superconducting radio-frequency technology using Niobium cavities as the accelerating structures. The accelerator can be extended to 1 TeV and also run as a Higgs factory at around 250 GeV and on the Z0 pole. A comprehensive value estimate of the accelerator is give, together with associated uncertainties. It is shown that no significant technical issues remain to be solved. Once a site is selected and the necessary site-dependent engineering is carried out, construction can begin immediately. The TDR also gives baseline documentation for two high-performance detectors that can share the ILC luminosity by being moved into and out of the beam line in a "push-pull" configuration. These detectors, ILD and SiD, are described in detail. They form the basis for a world-class experimental programme that promises to increase significantly our understanding of the fundamental processes that govern the evolution of the Universe.

  14. International Linear Collider Technical Review Committee Report, 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-01

    This 1995 report of the International Linear Collider Technical Review Committee is the first attempt to gather in one document the current status of all major e{sup +}e{sup {minus}} linear collider projects in the world. The report is the result of a collaborative effort of scientists from many laboratories working together over a period of about one year. A short description of the organization, origins and history of the report is given below. To get an idea of the organization, the reader should first refer to the Table of Contents. Chapter 1 is an introduction and general overview of the respective 500 GeV c.m. energy machines. In contrast, Chapter 2, cutting across individual machine boundaries, gives a comparative description and discussion of all the major machine sub-systems as well as particle physics experimentation, showing where these subjects stand today and what additional work needs to be done in the next few years to reach the point where complete design reports can be prepared. Chapter 3 describes the various paths to energy upgrades, and other experimental options ({gamma}{gamma}, e{sup {minus}}e{sup {minus}}, etc.). Chapter 4 gives a short status report of the machine experiments and test facilities being built in the world. Chapter 5 outlines current and other possible areas of collaboration and finally., Chapter 6 summarizes our principal conclusions.

  15. International linear collider physics and detectors. 2011 status report

    Energy Technology Data Exchange (ETDEWEB)

    Brau, James E. [Oregon Univ., OR (United States); Fuster, Juan [Instituto de Fisica Corpuscular, Valencia (Spain); Hesla, Leah [Fermi National Accelerator Lab., Batavia, IL (United States). NASA/Fermilab Astrophysics Center; Illenseer, Monika; Warmbein, Barbara [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Royole-Degieux, Perrine [CNRS/IN2P3, Paris (France); Takahashi, Rika [High Energy Accelerator Research Organization (KEK), Tsukuba, Ibaraki (Japan); Yamada, Sakue [High Energy Accelerator Research Organization (KEK), Tsukuba, Ibaraki (Japan); Tokyo Univ. (Japan); Yamamoto, Hitoshi [Tohoku Gakuin Univ., Sendai (Japan); Min, Zhang (eds.) [IHEP, Beijing (China)

    2011-07-01

    The studies of physics and detectors for the International Linear Collider are an important parallel element to the effort for the ILC Technical Design Report. The studies comprise the physics opportunities, detector requirements, and detector development to achieve the challenging high performance demanded by the physics, as well as integration of detectors into the accelerator. The current phase of this effort began with a call for Letters of Intent (LOIs) in 2007 and will lead to the submission of Detailed Baseline Design (DBD) report together with the ILC Technical Design Report at the end of 2012. Here we summarise the current status of this process, review what it has accomplished and identify the work that still needs to be completed. This report, titled International Linear Collider Physics and Detectors: 2011 Status Report, does just this. This report begins with a discussion of the outstanding issues in physics that motivate the construction of the ILC. It describes the organisation of the LOI process, the validation of the LOIs by the International Detector Advisory Group, and the results of R and D carried out to support the detector designs. The details of the concept detectors have already been published in the LOIs, which were completed in 2009. This report will, in a complementary way, describe the status of the detector R and D for each individual detector component and the status of the physics simulation infrastructure that has been built for the detector design process. Much of this work is carried out in cooperation between the two detector concept groups. This report describes the five common task groups and two working groups that have organised these cooperative activities. Many members of the detector concept groups and the common task groups have contributed to this report. Many more people have carried out the actual work that is reviewed. The complete list of members of each detector concept group can be found from the author lists of

  16. Treatment of linear alkylbenzene sulfonate (LAS) wastewater by internal electrolysis--biological contact oxidation process.

    Science.gov (United States)

    Cao, X Z; Li, Y M

    2011-01-01

    Surfactant wastewater is usually difficult to treat due to its toxicity and poor biodegradability. A separate physico-chemical or biochemical treatment method achieves a satisfactory effect with difficulty. In this study, treatment of the wastewater collected from a daily chemical plant by the combination processes of Fe/C internal electrolysis and biological contact oxidation was investigated. For the internal electrolysis process, the optimal conditions were: pH = 4-5, Fe/C = (10-15):1, air-water ratio = (10-20):1 and hydraulic retention time (HRT)= 2 h. For the biological contact oxidation process, the optimal conditions were: HRT = 12 h, DO = 4.0-5.0 mg/L. Treated by the above combined processes, the effluent could meet the I-grade criteria specified in Integrated Wastewater Discharge Standard of China (GB 8978-1996). The results provide valuable information for full-scale linear alkylbenzene sulfonate wastewater treatment.

  17. Fluid electron, gyrokinetic ion simulations of linear internal kink and energetic particle modes

    Energy Technology Data Exchange (ETDEWEB)

    Cole, Michael, E-mail: michael.cole@ipp.mpg.de; Mishchenko, Alexey; Könies, Axel; Kleiber, Ralf; Borchardt, Matthias [Max-Planck-Institut für Plasmaphysik, D-17491 Greifswald (Germany)

    2014-07-15

    The internal kink mode is an important plasma instability responsible for a broad class of undesirable phenomena in tokamaks, including the sawtooth cycle and fishbones. To predict and discover ways to mitigate this behaviour in current and future devices, numerical simulations are necessary. The internal kink mode can be modelled by reduced magnetohydrodynamics (MHD). Fishbone modes are an inherently kinetic and non-linear phenomenon based on the n = 1 Energetic Particle Mode (EPM), and have been studied using hybrid codes that combine a reduced MHD bulk plasma model with a kinetic treatment of fast ions. In this work, linear simulations are presented using a hybrid model which couples a fluid treatment of electrons with a gyrokinetic treatment of both bulk and fast ions. Studies of the internal kink mode in geometry relevant to large tokamak experiments are presented and the effect of gyrokinetic ions is considered. Interaction of the kink with gyrokinetic fast ions is also considered, including the destabilisation of the linear n = 1 EPM underlying the fishbone.

  18. International Linear Collider-A Technical Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Elsen, Eckhard; /DESY; Harrison, Mike; /Brookhaven; Hesla, Leah; /Fermilab; Ross, Marc; /Fermilab; Royole-Degieux, Perrine; /Paris, IN2P3; Takahashi, Rika; /KEK, Tsukuba; Walker, Nicholas; /DESY; Warmbein, Barbara; /DESY; Yamamoto, Akira; /KEK, Tsukuba; Yokoya, Kaoru; /KEK, Tsukuba; Zhang, Min; /Beijing, Inst. High Energy Phys.

    2011-11-04

    The International Linear Collider: A Technical Progress Report marks the halfway point towards the Global Design Effort fulfilling its mandate to follow up the ILC Reference Design Report with a more optimised Technical Design Report (TDR) by the end of 2012. The TDR will be based on much of the work reported here and will contain all the elements needed to propose the ILC to collaborating governments, including a technical design and implementation plan that are realistic and have been better optimised for performance, cost and risk. We are on track to develop detailed plans for the ILC, such that once results from the Large Hadron Collider (LHC) at CERN establish the main science goals and parameters of the next machine, we will be in good position to make a strong proposal for this new major global project in particle physics. The two overriding issues for the ILC R&D programme are to demonstrate that the technical requirements for the accelerator are achievable with practical technologies, and that the ambitious physics goals can be addressed by realistic ILC detectors. This GDE interim report documents the impressive progress on the accelerator technologies that can make the ILC a reality. It highlights results of the technological demonstrations that are giving the community increased confidence that we will be ready to proceed with an ILC project following the TDR. The companion detector and physics report document likewise demonstrates how detector designs can meet the ambitious and detailed physics goals set out by the ILC Steering Committee. LHC results will likely affect the requirements for the machine design and the detectors, and we are monitoring that very closely, intending to adapt our design as those results become available.

  19. Linear elastic response of tubes to internal detonation loading

    NARCIS (Netherlands)

    Beltman, W.M.; Shepherd, J.E.

    2002-01-01

    This paper deals with the structural response of a tube to an internal gaseous detonation. An internal detonation produces a pressure load that propagates down the tube. Because the speed of the gaseous detonation can be comparable to the flexural wave group speed, excitation of flexural waves in th

  20. Internal and external stabilisation of linear systems with constraints

    NARCIS (Netherlands)

    Saberi, Ali; Stoorvogel, Anton A.; Sannuti, Peddapullaiah

    2012-01-01

    Linear systems with constraints on inputs and states are ubiquitous. Control of such systems has been a long-time challenge to control engineers and will continue to remain so. Indeed, the challenge of constraints is intense and dauntingly formidable and familiar. This book focuses on the very funda

  1. Stabilizing inverse problems by internal data. II: non-local internal data and generic linearized uniqueness

    KAUST Repository

    Kuchment, Peter

    2015-05-10

    © 2015, Springer Basel. In the previous paper (Kuchment and Steinhauer in Inverse Probl 28(8):084007, 2012), the authors introduced a simple procedure that allows one to detect whether and explain why internal information arising in several novel coupled physics (hybrid) imaging modalities could turn extremely unstable techniques, such as optical tomography or electrical impedance tomography, into stable, good-resolution procedures. It was shown that in all cases of interest, the Fréchet derivative of the forward mapping is a pseudo-differential operator with an explicitly computable principal symbol. If one can set up the imaging procedure in such a way that the symbol is elliptic, this would indicate that the problem was stabilized. In the cases when the symbol is not elliptic, the technique suggests how to change the procedure (e.g., by adding extra measurements) to achieve ellipticity. In this article, we consider the situation arising in acousto-optical tomography (also called ultrasound modulated optical tomography), where the internal data available involves the Green’s function, and thus depends globally on the unknown parameter(s) of the equation and its solution. It is shown that the technique of (Kuchment and Steinhauer in Inverse Probl 28(8):084007, 2012) can be successfully adopted to this situation as well. A significant part of the article is devoted to results on generic uniqueness for the linearized problem in a variety of situations, including those arising in acousto-electric and quantitative photoacoustic tomography.

  2. Software for the international linear collider: Simulation and reconstruction frameworks

    Indian Academy of Sciences (India)

    Ties Behnke; Frank Gaede; DESY Hamburg

    2007-12-01

    Software plays an increasingly important role already in the early stages of a large project like the ILC. In international collaboration a data format for the ILC detector and physics studies has been developed. Building upon this software frameworks are made available which ease the event reconstruction and analysis.

  3. International Linear Collider Steering Committee issues charge to Technology Recommendation Panel

    CERN Multimedia

    2003-01-01

    "Following its November 19 meeting in Paris, the International Linear Collider Steering Committee, a subcommittee of the International Committee for Future Accelerators, has published the charge http://www.fnal.gov/directorate/icfa/ITRP_Charge.pdf to the International Technology Recommendation Panel appointed by ICFA" (2 paragraphs).

  4. The tanh-coth method combined with the Riccati equation for solving non-linear equation

    Energy Technology Data Exchange (ETDEWEB)

    Bekir, Ahmet [Dumlupinar University, Art-Science Faculty, Department of Mathematics, Kuetahya (Turkey)], E-mail: abekir@dumlupinar.edu.tr

    2009-05-15

    In this work, we established abundant travelling wave solutions for some non-linear evolution equations. This method was used to construct solitons and traveling wave solutions of non-linear evolution equations. The tanh-coth method combined with Riccati equation presents a wider applicability for handling non-linear wave equations.

  5. On linear internal waves on the sea, strongly vertically trapped

    Directory of Open Access Journals (Sweden)

    E. SALUSTI

    1975-05-01

    Full Text Available We study some explicit cases of marine thermocline. We focus our attention on the strongly vertically trapped internal waves, which in our cases allow an explicit dispersion relation and a simple behaviour in terms of elementary functions. The explicit form of the Vaisala-Brunt frequency N2{z is proportional to 1 / z—20| in one case and to A2—B2(z—zD2 in the other. A comparison with some experimental data concerning the Ligurian Sea is actually in course.

  6. Non-linear fate of internal wave attractors

    CERN Document Server

    Scolan, Hélène; Dauxois, Thierry

    2013-01-01

    We present a laboratory study on the instability of internal wave attractors in a trapezoidal fluid domain filled with uniformly stratified fluid. Energy is injected into the system via standing-wave-type motion of a vertical wall. Attractors are found to be destroyed by parametric subharmonic instability (PSI) via a triadic resonance which is shown to provide a very efficient energy pathway from long to short length scales. This study provides an explanation why attractors may be difficult or impossible to observe in natural systems subject to large amplitude forcing.

  7. Report on the international workshop on next generation linear colliders

    Energy Technology Data Exchange (ETDEWEB)

    Ruth, R.D.

    1989-05-01

    Many laboratories around the world have begun vigorous research programs on a next generation linear collider (NLC). However, it has been recognized that the research towards NLC is beyond the capabilities of any one laboratory presently. This workshop was organized to begin a series of workshops that address this problem. Specifically, the main goals of the workshop were to discuss research programs of the various laboratories around the world, to identify common areas of interest in the various NLC designs, and finally to advance these programs by collaboration. The particular topics discussed briefly in this paper are: parameters, rf power, structures, final focus, beam dynamics, damping rings, and instrumentation. 2 refs., 3 figs., 6 tabs.

  8. Calorimetry at the international linear collider. From simulation to reality

    Energy Technology Data Exchange (ETDEWEB)

    Wattimena, Nanda

    2010-02-15

    Calorimetry plays a crucial role in ongoing and upcoming high-energy physics experiments. To build a powerful calorimetric system with a performance tailored to the expected physics signatures, demands dedicated research and development of new readout technologies as well as dedicated reconstruction algorithms. The presented design of a calorimetric system which meets the high demands of precision physics at the future linear collider ILC, follows the paradigm of particle ow. Particle ow is a reconstruction principle that relies on a calorimetric system with high spatial granularity. In the detector optimisation process, the development of hardware and software are interlinked and cannot be judged independently. This thesis addresses two different aspects of detector optimisation, a test of the detector design against one example physics scenario and the development of a stable calibration procedure. In the rst part, a gauge-mediated Supersymmetry breaking scenario is used to test the design of the electromagnetic calorimeter in a full detector simulation study. The reconstruction of the neutralino properties, each decaying into a photon and a gravitino, requires a good energy resolution, as well as excellent position and angular resolution. The error bounds on the neutralino mass is strongly linked to the energy resolution, while the position and angular reconstruction of neutral particles is essential for the determination of the neutralino lifetime. The second part of this thesis focuses on the calibration procedure for a prototype of the hadron calorimeter. 7608 novel photodetectors are operated and tested in this prototype. They are exposed to beams of well de ned particle type and energy. The calibration is tested with a detailed study of electromagnetic showers inside the cubic-metre-sized prototype, with special attention paid towards the non-linearity correction. (orig.)

  9. Applications of Probabilistic Combiners on Linear Feedback Shift Register Sequences

    Science.gov (United States)

    2016-12-01

    for encrypting and decrypting data, each with advantages and disadvantages. If communicating parties require speed of encryption more than incredibly...different meth- ods are available for encrypting and decrypting data, each with advantages and disadvan- tages. If communicating parties require speed...LFSRs in a three-combiner, and second, by randomizing the order in which each of those LFSRs were added. We felt it unfair to compare the classic

  10. The international linear collider. Technical design report. Vol. 1. Executive summary

    Energy Technology Data Exchange (ETDEWEB)

    Behnke, Ties; Brau, James E.; Foster, Brian; Fuster, Juan; Harrison, Mike; McEwan Paterson, James; Peskin, Michael; Stanitzki, Marcel; Walker, Nicholas; Yamamoto, Hitoshi (eds.)

    2013-07-01

    A review is given about the planned International Linear Collider. Especially described are the technical design, the accelerator layout and design, the R and D during the technical design phase, and the detectors. (HSI)

  11. Detector and trigger challenge for supersymmetrical dark matter scenarios at the international linear collider

    Indian Academy of Sciences (India)

    Z Zhang

    2007-12-01

    Two supersymmetrical (SUSY) dark matter scenarios are discussed to illustrate how challenging it is to detect and trigger these events out of standard model background events at a future international linear collider (ILC).

  12. Phosphite Ligand Modified Supported Rhodium Catalyst for Hydroformylation of Internal Olefins to Linear Aldehydes

    Institute of Scientific and Technical Information of China (English)

    LI Xian-ming; DING Yun-jie; JIAO Gui-ping; LI Jing-wei; YAN Li; ZHU He-jun

    2009-01-01

    A phosphite ligand modified heterogeneous catalyst was developed for the hydroformylation of internal olefins to linear aldehydes, which showed a high activity and high regioselectivity and could be separated easily by filtration after reaction in an autoclave. Three nanoporous silica sieves were used to investigate the influence of pore structure and shape selective performance of support on the regioselectivity to the linear products.

  13. International Combined Orthopaedic Research Societies: A model for international collaboration to promote orthopaedic and musculoskeletal research

    Directory of Open Access Journals (Sweden)

    Theodore Miclau

    2014-10-01

    Full Text Available In October 2013, the International Combined Orthopaedic Research Societies (ICORS; http://i-cors.org was founded with inaugural member organisations from the previous Combined Orthopaedic Research Society, which had sponsored combined meetings for more than 2 decades. The ICORS is dedicated to the stimulation of orthopaedic and musculoskeletal research in fields such as biomedical engineering, biology, chemistry, and veterinary and human clinical research. The ICORS seeks to facilitate communication with member organisations to enhance international research collaborations and to promote the development of new international orthopaedic and musculoskeletal research organisations. Through new categories of membership, the ICORS represents the broadest coalition of orthopaedic research organisations globally.

  14. SELECTION OF THE LINEAR COMBINING VECTOR G OF THE GENERALIZED SELF-SHRINKING GENERATORS

    Institute of Scientific and Technical Information of China (English)

    Dong Lihua; Zeng Yong; Hu Yupu

    2006-01-01

    Given an m-sequence, the main factor influencing the least period of the Generalized Self-Shrinking (GSS) sequence is the selection of the linear combining vector G. Based on the calculation of the minimalpolynomial ofL GSS sequences and the comparison of their degrees, an algorithm for selecting the linear combining vector G is presented, which is simple to understand, to implement and to prove. By using this method,much more than 2L-1 linear combining vectors G of the desired properties will be resulted. Thus in the practical application the linear combining vector G can be chosen with great arbitrariness. Additionally, this algorithm can be extended to any finite field easily.

  15. The Symmetry Properties of Linear Combination Coefficients for Molecular Orbitals of Diatomic Molecules

    Institute of Scientific and Technical Information of China (English)

    Metin Orbay; Telhat Ozdogan

    2003-01-01

    In this paper, the symmetry properties of linear combination coefficients for molecular orbitals of diatomicmolecules, using Slater type orbitals, are presented with the help of the symmetry operations in group theory. In order totest the presented symmetry properties, the linear combination coefficients of molecular orbitalsfor the ground electronicstate of pilot molecules F2 and CO are calculated using constructed computer programs for Hartree-Fock-Roothaanequation. It is seen that the obtained computing results satisfy the presented symmetry properties.

  16. An analytical study on the carrier-phase linear combinations for triple-frequency GNSS

    Science.gov (United States)

    Li, Jinlong; Yang, Yuanxi; He, Haibo; Guo, Hairong

    2016-08-01

    The linear combinations of multi-frequency carrier-phase measurements for Global Navigation Satellite System (GNSS) are greatly beneficial to improving the performance of ambiguity resolution (AR), cycle slip correction as well as precise positioning. In this contribution, the existing definitions of the carrier-phase linear combination are reviewed and the integer property of the resulting ambiguity of the phase linear combinations is examined. The general analytical method for solving the optimal integer linear combinations for all triple-frequency GNSS is presented. Three refined triple-frequency integer combinations solely determined by the frequency values are introduced, which are the ionosphere-free (IF) combination that the Sum of its integer coefficients equal to 0 (IFS0), the geometry-free (GF) combination that the Sum of its integer coefficients equal to 0 (GFS0) and the geometry-free and ionosphere-free (GFIF) combination. Besides, the optimal GF, IF, extra-wide lane and ionosphere-reduced integer combinations for GPS and BDS are solved exhaustively by the presented method. Their potential applications in cycle slip detection, AR as well as precise positioning are discussed. At last, a more straightforward GF and IF AR scheme than the existing method is presented based on the GFIF integer combination.

  17. An analytical study on the carrier-phase linear combinations for triple-frequency GNSS

    Science.gov (United States)

    Li, Jinlong; Yang, Yuanxi; He, Haibo; Guo, Hairong

    2017-02-01

    The linear combinations of multi-frequency carrier-phase measurements for Global Navigation Satellite System (GNSS) are greatly beneficial to improving the performance of ambiguity resolution (AR), cycle slip correction as well as precise positioning. In this contribution, the existing definitions of the carrier-phase linear combination are reviewed and the integer property of the resulting ambiguity of the phase linear combinations is examined. The general analytical method for solving the optimal integer linear combinations for all triple-frequency GNSS is presented. Three refined triple-frequency integer combinations solely determined by the frequency values are introduced, which are the ionosphere-free (IF) combination that the Sum of its integer coefficients equal to 0 (IFS0), the geometry-free (GF) combination that the Sum of its integer coefficients equal to 0 (GFS0) and the geometry-free and ionosphere-free (GFIF) combination. Besides, the optimal GF, IF, extra-wide lane and ionosphere-reduced integer combinations for GPS and BDS are solved exhaustively by the presented method. Their potential applications in cycle slip detection, AR as well as precise positioning are discussed. At last, a more straightforward GF and IF AR scheme than the existing method is presented based on the GFIF integer combination.

  18. Design of main linac emittance tuning bumps for the Compact Linear Collider and the International Linear Collider

    Directory of Open Access Journals (Sweden)

    Peder Eliasson

    2008-01-01

    Full Text Available The installation of elements in the main linac of future linear colliders can only be done with a limited precision. The inevitable misalignments lead to unacceptable emittance growth. Beam-based alignment, e.g., one-to-one correction, dispersion free steering, or ballistic alignment, is necessary to reduce the emittance growth. In some cases, this is, however, not sufficient. For further reduction of the emittance growth, so-called emittance tuning bumps have to be used. A general strategy for the design of emittance tuning bumps has been developed and tested. Simulations suggest that the method can be conveniently used to understand the weaknesses of existing emittance tuning bumps and to significantly improve their performance in terms of, e.g., emittance reduction capability and convergence speed. An example of an application is the design of ten orthogonal knobs that, according to simulations, can reduce the normalized emittance growth in the Compact Linear Collider (CLIC main linac from 23.8 to 0.34 nm with convergence within two iterations. Four orthogonal knobs have also been designed for the International Linear Collider (ILC. Simulations show that these knobs converge within a single iteration and reduce normalized emittance growth from 3.8 to 0.05 nm.

  19. Linear Stability Analysis of Flow in an Internally Heated Rectangular Duct

    Energy Technology Data Exchange (ETDEWEB)

    Uhlmann, M.

    2004-07-01

    The linear stability of flow in a vertical rectangular duct subject to homogeneous internal heating, constant-temperature no-slip walls and a driving pressure gradient is investigated numerically. A full Chebyshevbased Galerkin method is found to be more reliable than a collocation method, both including the elimination of the pressure and the stream wise velocity from the system of equations and making use of the full symmetry properties. A classification of the mean flow-obtained as a function of Grashof and Reynolds numbers and the geometrical aspect ratio in terms of its inflectional properties is proposed. It is found that the flow loses stability at all aspects rations for a combination of finite thermal buoyancy and pressure forces with opposed sings. In the square duct, the unstable region coincides with the range where additional inflection lines are observed the mean velocity profile. Unstable eigenfunctions are obtained for all basic symmetry modes and their structure can be described as slightly elongated pockets of cross-stream-vertical motion, training each other along the stream wise direction. (Author) 22 refs.

  20. Event generation for next to leading order chargino production at the international linear collider

    Energy Technology Data Exchange (ETDEWEB)

    Robens, T.

    2006-10-15

    At the International Linear Collider (ILC), parameters of supersymmetry (SUSY) can be determined with an experimental accuracy matching the precision of next-to-leading order (NLO) and higher-order theoretical predictions. Therefore, these contributions need to be included in the analysis of the parameters. We present a Monte-Carlo event generator for simulating chargino pair production at the ILC at next-to-leading order in the electroweak couplings. We consider two approaches of including photon radiation. A strict fixed-order approach allows for comparison and consistency checks with published semianalytic results in the literature. A version with soft- and hard-collinear resummation of photon radiation, which combines photon resummation with the inclusion of the NLO matrix element for the production process, avoids negative event weights, so the program can simulate physical (unweighted) event samples. Photons are explicitly generated throughout the range where they can be experimentally resolved. In addition, it includes further higher-order corrections unaccounted for by the fixed-order method. Inspecting the dependence on the cutoffs separating the soft and collinear regions, we evaluate the systematic errors due to soft and collinear approximations for NLO and higher-order contributions. In the resummation approach, the residual uncertainty can be brought down to the per-mil level, coinciding with the expected statistical uncertainty at the ILC. We closely investigate the two-photon phase space for the resummation method. We present results for cross sections and event generation for both approaches. (orig.)

  1. A vertically integrated pixel readout device for the Vertex Detector at the International Linear Collider

    Energy Technology Data Exchange (ETDEWEB)

    Deptuch, Grzegorz; Christian, David; Hoff, James; Lipton, Ronald; Shenai, Alpana; Trimpl, Marcel; Yarema, Raymond; Zimmerman, Tom; /Fermilab

    2008-12-01

    3D-Integrated Circuit technology enables higher densities of electronic circuitry per unit area without the use of nanoscale processes. It is advantageous for mixed mode design with precise analog circuitry because processes with conservative feature sizes typically present lower process dispersions and tolerate higher power supply voltages, resulting in larger separation of a signal from the noise floor. Heterogeneous wafers (different foundries or different process families) may be combined with some 3D integration methods, leading to the optimization of each tier in the 3D stack. Tracking and vertexing in future High-Energy Physics (HEP) experiments involves construction of detectors composed of up to a few billions of channels. Readout electronics must record the position and time of each measurement with the highest achievable precision. This paper reviews a prototype of the first 3D readout chip for HEP, designed for a vertex detector at the International Linear Collider. The prototype features 20 x 20 {micro}m{sup 2} pixels, laid out in an array of 64 x 64 elements and was fabricated in a 3-tier 0.18 {micro}m Fully Depleted SOI CMOS process at MIT-Lincoln Laboratory. The tests showed correct functional operation of the structure. The chip performs a zero-suppressed readout. Successive submissions are planned in a commercial 3D bulk 0.13 {micro}m CMOS process to overcome some of the disadvantages of an FDSOI process.

  2. New final doublets and power densities for the international linear collider small crossing angle layout

    Indian Academy of Sciences (India)

    R Appleby; P Bambade

    2007-12-01

    In this paper we use current and proposed final doublet magnet technologies to reoptimise the interaction region of the international linear collider and reduce the power losses. The result is a set of three new final doublet layouts with improved beam transport properties. The effect of localised power deposition and it's reduction using tungsten liners are considered.

  3. Combining biomarkers linearly and nonlinearly for classification using the area under the ROC curve.

    Science.gov (United States)

    Fong, Youyi; Yin, Shuxin; Huang, Ying

    2016-09-20

    In biomedical studies, it is often of interest to classify/predict a subject's disease status based on a variety of biomarker measurements. A commonly used classification criterion is based on area under the receiver operating characteristic curve (AUC). Many methods have been proposed to optimize approximated empirical AUC criteria, but there are two limitations to the existing methods. First, most methods are only designed to find the best linear combination of biomarkers, which may not perform well when there is strong nonlinearity in the data. Second, many existing linear combination methods use gradient-based algorithms to find the best marker combination, which often result in suboptimal local solutions. In this paper, we address these two problems by proposing a new kernel-based AUC optimization method called ramp AUC (RAUC). This method approximates the empirical AUC loss function with a ramp function and finds the best combination by a difference of convex functions algorithm. We show that as a linear combination method, RAUC leads to a consistent and asymptotically normal estimator of the linear marker combination when the data are generated from a semiparametric generalized linear model, just as the smoothed AUC method. Through simulation studies and real data examples, we demonstrate that RAUC outperforms smooth AUC in finding the best linear marker combinations, and can successfully capture nonlinear pattern in the data to achieve better classification performance. We illustrate our method with a dataset from a recent HIV vaccine trial. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  4. Dynamical analysis of mesoscale eddy-induced ocean internal waves using linear theories

    Institute of Scientific and Technical Information of China (English)

    XU Qing; ZHENG Quanan; LIN Hui; LIU Yuguang; SONG YTony; YUAN Yeli

    2008-01-01

    This study aims to explore generation mechanisms of the ocean internal wave using the dynamical analysis methods based on linear theories. Historical cruise measurements and recent synthetic aperture radar (SAR) observations of mesoscale eddies with diame-ter of several tens of kilometers to hundreds of kilometers show that the internal wave packets with wavelength of hundreds of me-ters to kilometer exist inside the mesoscale eddies. This coexistence phenomenon and inherent links between the two different scale processes are revealed in the solutions of governing equations and boundary conditions for the internal wave disturbance with a horizontally slowly variable amplitude in a cylindrical coordinate system. The theoretical solutions indicate that the instability of eddy current field provides the dynamical mechanism to internal wave generation. The derived dispersion relation indicates that the internal wave propagation is modified by the eddy current field structure. The energy equation of the internal waves clearly shows the internal wave energy increment comes from the eddy. The theoretical models are used to explain the observation of the mesoscale ed-dy-induced internal waves off the Norwegian coast. The two-dimensional waveform solution of the anticyclonic eddy-induced internal wave packet appears as ring-shaped curves, which contains the typical features of eddy stream lines. The comparison of theoretical solutions to the structure of the internal wave packets on SAR image shows a good agreement on the major features.

  5. On Linear Combinations of Two Orthogonal Polynomial Sequences on the Unit Circle

    Directory of Open Access Journals (Sweden)

    Suárez C

    2010-01-01

    Full Text Available Let be a monic orthogonal polynomial sequence on the unit circle. We define recursively a new sequence of polynomials by the following linear combination: , , . In this paper, we give necessary and sufficient conditions in order to make be an orthogonal polynomial sequence too. Moreover, we obtain an explicit representation for the Verblunsky coefficients and in terms of and . Finally, we show the relation between their corresponding Carathéodory functions and their associated linear functionals.

  6. Simultaneous Inference on All Linear Combinations of Means with Heteroscedastic Errors

    Directory of Open Access Journals (Sweden)

    Xin Yan

    2011-01-01

    Full Text Available We proposed a statistical method to construct simultaneous confidence intervals on all linear combinations of means without assuming equal variance where the classical Scheffé's simultaneous confidence intervals no longer preserve the familywise error rate (FWER. The proposed method is useful when the number of comparisons on linear combinations of means is extremely large. The FWERs for proposed simultaneous confidence intervals under various configurations of mean variances are assessed through simulations and are found to preserve the predefined nominal level very well. An example of pairwise comparisons on heteroscedastic means is given to illustrate the proposed method.

  7. Measuring the Higgs self-coupling at the International Linear Collider

    Energy Technology Data Exchange (ETDEWEB)

    Duerig, Claude Fabienne

    2016-10-15

    In this thesis, the experimental prospects of measuring the Standard Model (SM) Higgs self-coupling λ{sub SM} at the International Linear Collider (ILC) are investigated. The observation of double Higgs production is necessary to directly establish a non-zero Higgs self-coupling. Information on λ{sub SM} can be extracted from a measurement of the cross section for this process. At a centre-of-mass energy of √(s)=500 GeV double Higgs-strahlung is the dominant Higgs-pair production process. This measurement is extremely challenging due to very small production cross sections and multi-jet final states which pose large challenges to detector technologies and event reconstruction techniques. A detailed full detector simulation of the International Large Detector is performed for a Higgs boson with a mass of 125 GeV. The analysis is based on ILC beam parameters according to the Technical Design Report and investigates several improvements compared to earlier studies. These include an isolated lepton selection strategy and the application of kinematic fits to final states with heavy-flavoured jets. Depending on the decay mode of the Z boson, relative improvements of up to 25% are obtained in the selection of ZHH (HH → bbbb) events. This results in a relative improvement of 10% in the measurement of σ{sub ZHH} when combining all channels. For the SM scenario, an evidence of 3.5σ for the observation of double Higgs-strahlung and a measurement precision of 30% on σ{sub ZHH} is reached with an integrated luminosity of L=2ab{sup -1} and a beam polarisation of P(e{sup +}e{sup -})=(0.3,-0.8). The result extrapolates to an achievable precision of 21% on σ{sub ZHH} after the full ILC running scenario, which corresponds to a 5.9σ discovery for the observation of double Higgs-strahlung. Combined with the channel HH→bbWW, σ{sub ZHH} can even be measured to a precision of 16%, which corresponds to a precision of 26% on λ{sub SM}. Additionally, the impact of

  8. Time-Frequency Analysis of Non-Stationary Biological Signals with Sparse Linear Regression Based Fourier Linear Combiner

    Directory of Open Access Journals (Sweden)

    Yubo Wang

    2017-06-01

    Full Text Available It is often difficult to analyze biological signals because of their nonlinear and non-stationary characteristics. This necessitates the usage of time-frequency decomposition methods for analyzing the subtle changes in these signals that are often connected to an underlying phenomena. This paper presents a new approach to analyze the time-varying characteristics of such signals by employing a simple truncated Fourier series model, namely the band-limited multiple Fourier linear combiner (BMFLC. In contrast to the earlier designs, we first identified the sparsity imposed on the signal model in order to reformulate the model to a sparse linear regression model. The coefficients of the proposed model are then estimated by a convex optimization algorithm. The performance of the proposed method was analyzed with benchmark test signals. An energy ratio metric is employed to quantify the spectral performance and results show that the proposed method Sparse-BMFLC has high mean energy (0.9976 ratio and outperforms existing methods such as short-time Fourier transfrom (STFT, continuous Wavelet transform (CWT and BMFLC Kalman Smoother. Furthermore, the proposed method provides an overall 6.22% in reconstruction error.

  9. Time-Frequency Analysis of Non-Stationary Biological Signals with Sparse Linear Regression Based Fourier Linear Combiner.

    Science.gov (United States)

    Wang, Yubo; Veluvolu, Kalyana C

    2017-06-14

    It is often difficult to analyze biological signals because of their nonlinear and non-stationary characteristics. This necessitates the usage of time-frequency decomposition methods for analyzing the subtle changes in these signals that are often connected to an underlying phenomena. This paper presents a new approach to analyze the time-varying characteristics of such signals by employing a simple truncated Fourier series model, namely the band-limited multiple Fourier linear combiner (BMFLC). In contrast to the earlier designs, we first identified the sparsity imposed on the signal model in order to reformulate the model to a sparse linear regression model. The coefficients of the proposed model are then estimated by a convex optimization algorithm. The performance of the proposed method was analyzed with benchmark test signals. An energy ratio metric is employed to quantify the spectral performance and results show that the proposed method Sparse-BMFLC has high mean energy (0.9976) ratio and outperforms existing methods such as short-time Fourier transfrom (STFT), continuous Wavelet transform (CWT) and BMFLC Kalman Smoother. Furthermore, the proposed method provides an overall 6.22% in reconstruction error.

  10. Combined Sliding Mode Control with a Feedback Linearization for Speed Control of Induction Motor

    Directory of Open Access Journals (Sweden)

    Aamir Hashim Obeid Ahmed

    2011-06-01

    Full Text Available Induction Motor (IM speed control is an area of research that has been in prominence for some time now. In this paper, a nonlinear controller is presented for IM drives. The nonlinear controller is designed based on input-output feedback linearization control technique, combined with sliding mode control (SMC to obtain a robust, fast and precise control of IM speed. The input-output feedback linearization control decouples the flux control from the speed control and makes the synthesis of linear controllers possible. To validate the performances of the proposed control scheme, we provided a series of simulation results and a comparative study between the performances of the proposed control strategy and those of the feedback linearization control (FLC schemes. Simulation results show that the proposed control strategy scheme shows better performance than the FLC strategy in the face of system parameters variation

  11. Permutation test for non-inferiority of the linear to the optimal combination of multiple tests.

    Science.gov (United States)

    Jin, Hua; Lu, Ying

    2009-03-01

    We proposed a permutation test for non-inferiority of the linear discriminant function to the optimal combination of multiple tests based on Mann-Whitney statistic estimate of the area under the receiver operating characteristic curve. Monte Carlo simulations showed its good performance.

  12. Hamiltonian discontinuous Galerkin FEM for linear, stratified (in)compressible Euler equations: internal gravity waves

    Science.gov (United States)

    van Oers, Alexander M.; Maas, Leo R. M.; Bokhove, Onno

    2017-02-01

    The linear equations governing internal gravity waves in a stratified ideal fluid possess a Hamiltonian structure. A discontinuous Galerkin finite element method has been developed in which this Hamiltonian structure is discretized, resulting in conservation of discrete analogs of phase space and energy. This required (i) the discretization of the Hamiltonian structure using alternating flux functions and symplectic time integration, (ii) the discretization of a divergence-free velocity field using Dirac's theory of constraints and (iii) the handling of large-scale computational demands due to the 3-dimensional nature of internal gravity waves and, in confined, symmetry-breaking fluid domains, possibly its narrow zones of attraction.

  13. Internal end-effect problem in a linear asynchronous MHD machine with arbitrary current load

    Energy Technology Data Exchange (ETDEWEB)

    Vilnitis, A.Ya.

    1977-01-01

    The internal end-effect problem in a bilateral linear asynchronous engine is solved by variation of constants for a surface current load of any type, including discrete conductors. Mathematically correct formulae for this case are given for computing the mechanical force on wound coils and the active power. Known methods of end-effect compensation are examined. The requirements for the surface load of inductors were found for the case where the requirements may be limited to an internal problem and scattering along the magnetic circuit ends.

  14. Higgs self-coupling in the fusion channel at the international linear collider

    Indian Academy of Sciences (India)

    K Moeing; A Rosca

    2007-11-01

    We investigate the Higgs pair production process at the international linear collider (ILC), focusing on the measurement of the trilinear self-coupling of the Higgs boson in the fusion channel. The sensitivity of this measurement is discussed in the Higgs mass range 140-200 GeV at a center-of-mass energy between 1 TeV and 1.5 TeV.

  15. Probing space-time structure of new physics with polarized beams at the international linear collider

    Indian Academy of Sciences (India)

    B Ananthanarayan

    2007-11-01

    At the international linear collider large beam polarization of both the electron and positron beams will enhance the signature of physics due to interactions that are beyond the standard model. Here we review our recently obtained results on a general model-independent method of determining for an arbitary one-particle inclusive state the space-time structure of such new physics through the beam polarization dependence and angular distribution of the final state particle.

  16. Monte Carlo based studies of a polarized positron source for international linear collider (ILC).

    OpenAIRE

    Schälicke, A.; Dollan, R.; Laihem, K.

    2006-01-01

    The full exploitation of the physics potential of an International Linear Collider (ILC) requires the development of a polarized positron beam. New concepts of polarized positron sources are based on the development of circularly polarized photon sources. The polarized photons create electron-positron pairs in a thin target and transfer their polarization state to the outgoing leptons. To achieve a high level of positron polarization the understanding of the production mechanisms in the targe...

  17. The road towards the international linear collider: Higgs, top/quantum chromodynamics, loops

    Indian Academy of Sciences (India)

    S Heinemeyer

    2007-11-01

    The international linear +− collider (ILC) could go into operation in the second half of the upcoming decade. Experimental analyses and theory calculations for the physics at the ILC are currently performed. We review recent progress, as presented at the LCWS06 in Bangalore, India, in the fields of Higgs boson physics and top/QCD. Also the area of loop calculations, necessary to achieve the required theory precision, is included.

  18. Cogging force rejection method of linear motor based on internal model principle

    Science.gov (United States)

    Liu, Yang; Chen, Zhenyu; Yang, Tianbo

    2015-02-01

    The cogging force disturbance of linear motor is one of the main factors affecting the positioning accuracy of ultraprecision moving platform. And this drawback could not be completely overcome by improving the design of motor body, such as location modification of permanent magnet array, or optimization design of the shape of teeth-slot. So the active compensation algorithms become prevalent in cogging force rejection area. This paper proposed a control structure based on internal mode principle to attenuate the cogging force of linear motor which deteriorated the accuracy of position, and this structure could make tracking and anti-disturbing performance of close-loop designed respectively. In the first place, the cogging force was seen as the intrinsic property of linear motor and its model constituting controlled object with motor ontology model was obtained by data driven recursive identification method. Then, a control structure was designed to accommodate tracking and anti-interference ability separately by using internal model principle. Finally, the proposed method was verified in a long stroke moving platform driven by linear motor. The experiment results show that, by employing this control strategy, the positioning error caused by cogging force was decreased by 70%.

  19. LOW COMPLEXITY LMMSE TURBO EQUALIZATION FOR COMBINED ERROR CONTROL CODED AND LINEARLY PRECODED OFDM

    Institute of Scientific and Technical Information of China (English)

    Qu Daiming; Zhu Guangxi

    2006-01-01

    The turbo equalization approach is studied for Orthogonal Frequency Division Multiplexing (OFDM) system with combined error control coding and linear precoding. While previous literatures employed linear precoder of small size for complexity reasons, this paper proposes to use a linear precoder of size larger than or equal to the maximum length of the equivalent discrete-time channel in order to achieve full frequency diversity and reduce complexities of the error control coder/decoder. Also a low complexity Linear Minimum Mean Square Error (LMMSE) turbo equalizer is derived for the receiver. Through simulation and performance analysis, it is shown that the performance of the proposed scheme over frequency selective fading channel reaches the matched filter bound; compared with the same coded OFDM without linear precoding, the proposed scheme shows an Signal-to-Noise Ratio (SNR) improvement of at least 6dB at a bit error rate of 10-6 over a multipath channel with exponential power delay profile. Convergence behavior of the proposed scheme with turbo equalization using various type of linear precoder/transformer, various interleaver size and error control coder of various constraint length is also investigated.

  20. Orthogonality, Lommel integrals and cross product zeros of linear combinations of Bessel functions.

    Science.gov (United States)

    Ziener, Christian H; Kurz, Felix T; Buschle, Lukas R; Kampf, Thomas

    2015-01-01

    The cylindrical Bessel differential equation and the spherical Bessel differential equation in the interval [Formula: see text] with Neumann boundary conditions are considered. The eigenfunctions are linear combinations of the Bessel function [Formula: see text] or linear combinations of the spherical Bessel functions [Formula: see text]. The orthogonality relations with analytical expressions for the normalization constant are given. Explicit expressions for the Lommel integrals in terms of Lommel functions are derived. The cross product zeros [Formula: see text] and [Formula: see text] are considered in the complex plane for real as well as complex values of the index [Formula: see text] and approximations for the exceptional zero [Formula: see text] are obtained. A numerical scheme based on the discretization of the two-dimensional and three-dimensional Laplace operator with Neumann boundary conditions is presented. Explicit representations of the radial part of the Laplace operator in form of a tridiagonal matrix allow the simple computation of the cross product zeros.

  1. Linear combination of power-law functions for detecting multiscaling using detrended fluctuation analysis

    Science.gov (United States)

    Echeverria, J. C.; Rodriguez, E.; Aguilar-Cornejo, M.; Alvarez-Ramirez, J.

    2016-10-01

    In many instances, the fluctuation function obtained from detrended fluctuation analysis (DFA) cannot be described by a uniform power-law function along scales. In fact, the manifestation of crossover scales may reflect the simultaneous action of different stochastic mechanisms displayed predominantly within certain scale ranges. This note proposes the use of a linear combination of power-law functions for adjusting DFA data. The idea is that each power-law function recast the dominance of certain stochastic mechanisms (e.g., the mean-reversion and long-term trends) at specific scale domains. Different values of the scaling exponents are numerically estimated by means of a nonlinear least-squares fitting of power-law functions. Examples of crude oil market and heart rate variability are discussed with some detail for illustrating the advantages of taking a linear combination of power-law functions for describing scaling behavior from DFA.

  2. Linear combinations of the third-order elastic and piezoelectric constants of quartz.

    Science.gov (United States)

    Hruska, C K

    1990-01-01

    The DC-field-induced change in the resonant frequency of the extentional mode of quartz rods is related to the third-order elastic and the third-order piezoelectric constants. Five linear combinations of these constants are determined by least-squares fit to data obtained from 50 different rods. The results are notable for their small standard errors of about two percent on average. They also agree very well with the values obtained independently by the transit-time method.

  3. Combined effects of cadmium and linear alkyl benzene sulfonate on Lemna minor L.

    Science.gov (United States)

    Singh, J; Chawla, G; Naqvi, S H; Viswanathan, P N

    1994-03-01

    : The effects of 0.1 ppm cadmium and 0.005% linear alkyl benzene sulfonates (LAS) on the uptake and metabolic incorporation of (14)C glycine by Lemna minor L., after 2, 24 and 48 h were studied for antagonistic/synergistic effects. Combined exposure was found to decrease the (14)C incorporation into proteins, DNA, RNA and phospholipids, to a greater extent than individual exposure. The presence of LAS increased the uptake of (109)Cd in the plants.

  4. The Combination of Internal-Combustion Engine and Gas Turbine

    Science.gov (United States)

    Zinner, K.

    1947-01-01

    While the gas turbine by itself has been applied in particular cases for power generation and is in a state of promising development in this field, it has already met with considerable success in two cases when used as an exhaust turbine in connection with a centrifugal compressor, namely, in the supercharging of combustion engines and in the Velox process, which is of particular application for furnaces. In the present paper the most important possibilities of combining a combustion engine with a gas turbine are considered. These "combination engines " are compared with the simple gas turbine on whose state of development a brief review will first be given. The critical evaluation of the possibilities of development and fields of application of the various combustion engine systems, wherever it is not clearly expressed in the publications referred to, represents the opinion of the author. The state of development of the internal-combustion engine is in its main features generally known. It is used predominantly at the present time for the propulsion of aircraft and road vehicles and, except for certain restrictions due to war conditions, has been used to an increasing extent in ships and rail cars and in some fields applied as stationary power generators. In the Diesel engine a most economical heat engine with a useful efficiency of about 40 percent exists and in the Otto aircraft engine a heat engine of greatest power per unit weight of about 0.5 kilogram per horsepower.

  5. Joint L-/C-Band Code and Carrier Phase Linear Combinations for Galileo

    Directory of Open Access Journals (Sweden)

    Patrick Henkel

    2008-01-01

    Full Text Available Linear code combinations have been considered for suppressing the ionospheric error. In the L-band, this leads to an increased noise floor. In a combined L- and C-band (5010–5030 MHz approach, the ionosphere can be eliminated and the noise floor reduced at the same time. Furthermore, combinations that involve both code- and carrier-phase measurements are considered. A new L-band code-carrier combination with a wavelength of 3.215 meters and a noise level of 3.92 centimeters is found. The double difference integer ambiguities of this combination can be resolved by extending the system of equations with an ionosphere-free L-/C-band code combination. The probability of wrong fixing is reduced by several orders of magnitude when C-band measurements are included. Carrier smoothing can be used to further reduce the residual variance of the solution. The standard deviation is reduced by a factor 7.7 if C-band measurements are taken into account. These initial findings suggest that the combined use of L- and C-band measurements, as well as the combined code and phase processing are an attractive option for precise positioning.

  6. PRINCIPAL PARAMETRIC AND THREE-TO-ONE INTERNAL RESONANCES OF FLEXIBLE BEAMS UNDERGOING A LARGE LINEAR MOTION

    Institute of Scientific and Technical Information of China (English)

    冯志华; 胡海岩

    2003-01-01

    A set of nonlinear differential equations is established by using Kane's method for the planar oscillation of flexible beams undergoing a large linear motion. In the case of a simply supported slender beam under certain average acceleration of base, the second natural frequency of the beam may approximate the tripled first one so that the condition of 3: i internal resonance of the beam holds true. The method of multiple scales is used to solve directly the nonlinear differential equations and to derive a set of nonlinear modulation equations for the principal parametric resonance of the first mode combined with 3: 1 internal resonance between the first two modes. Then, the modulation equations are numerically solved to obtain the steady-state response and the stability condition of the beam. The abundant nonlinear dynamic behaviors, such as various types of local bifurcations and chaos that do not appear for linear models, can be observed in the case studies. For a Hopf bifurcation,the 4-dimensional modulation equations are reduced onto the central manifold and the type of Hopf bifurcation is determined. As usual, a limit cycle may undergo a series of period-doubling bifurcations and become a chaotic oscillation at last.

  7. Linear inverse source estimate of combined EEG and MEG data related to voluntary movements.

    Science.gov (United States)

    Babiloni, F; Carducci, F; Cincotti, F; Del Gratta, C; Pizzella, V; Romani, G L; Rossini, P M; Tecchio, F; Babiloni, C

    2001-12-01

    A method for the modeling of human movement-related cortical activity from combined electroencephalography (EEG) and magnetoencephalography (MEG) data is proposed. This method includes a subject's multi-compartment head model (scalp, skull, dura mater, cortex) constructed from magnetic resonance images, multi-dipole source model, and a regularized linear inverse source estimate based on boundary element mathematics. Linear inverse source estimates of cortical activity were regularized by taking into account the covariance of background EG and MEG sensor noise. EEG (121 sensors) and MEG (43 sensors) data were recorded in separate sessions whereas normal subjects executed voluntary right one-digit movements. Linear inverse source solution of EEG, MEG, and EEG-MEG data were quantitatively evaluated by using three performance indexes. The first two indexes (Dipole Localization Error [DLE] and Spatial Dispersion [SDis]) were used to compute the localization power for the source solutions obtained. Such indexes were based on the information provided by the column of the resolution matrix (i.e., impulse response). Ideal DLE values tend to zero (the source current was correctly retrieved by the procedure). In contrast, high DLE values suggest severe mislocalization in the source reconstruction. A high value of SDis at a source space point mean that such a source will be retrieved by a large area with the linear inverse source estimation. The remaining performance index assessed the quality of the source solution based on the information provided by the rows of the resolution matrix R, i.e., resolution kernels. The i-th resolution kernels of the matrix R describe how the estimation of the i-th source is distorted by the concomitant activity of all other sources. A statistically significant lower dipole localization error was observed and lower spatial dispersion in source solutions produced by combined EEG-MEG data than from EEG and MEG data considered separately (P < 0

  8. Prototype testing and analysis of a novel internal combustion linear generator integrated power system

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Zhaoping; Chang, Siqin [School of Mechanical Engineering, Nanjing University of Science and Technology, Nanjing 210094 (China)

    2010-04-15

    A novel four-stroke free-piston engine equipped with a linear electric generator (namely internal combustion linear generator integrated power system) is proposed in this paper to achieve efficient energy conversion from fuel to electricity. Unique features of the novel power system are presented and their effects on the continuous running are discussed, along with potential advantages and disadvantages compared to conventional engines. A single cylinder, gasoline and spark ignition prototype is fabricated with reference to the geometric and control parameters of an existing conventional four-stroke engine. Stable running of the prototype is realized, and a 2.2 kW average output power with the generating efficiency of 32% has been obtained up to now. The feasibility and performance of the proposed design are verified. Detailed testing results from the continuous running prototype are analyzed in this paper for giving insight into the performance and dynamic behaviors of the novel power system. (author)

  9. Combining internally contracted states and matrix product states to perform multireference perturbation theory

    CERN Document Server

    Sharma, Sandeep; Guo, Sheng; Alavi, Ali

    2016-01-01

    We present two efficient and intruder-free methods for treating dynamic correlation on top of general multi-configuration reference wave functions---including such as obtained by the density matrix renormalization group (DMRG) with large active spaces. The new methods are the second order variant of the recently proposed multi-reference linearized coupled cluster method (MRLCC) [S. Sharma, A. Alavi, J. Chem. Phys. 143, 102815 (2015)], and of N-electron valence perturbation theory (NEVPT2), with expected accuracies similar to MRCI+Q and (at least) CASPT2, respectively. Great efficiency gains are realized by representing the first-order wave function with a combination of internal contraction (IC) and matrix product state perturbation theory (MPSPT). With this combination, only third order reduced density matrices (RDMs) are required. Thus, we obviate the need for calculating (or estimating) RDMs of fourth or higher order; these had so far posed a severe bottleneck for dynamic correlation treatments involving t...

  10. Selection of the optimum magnet design for the International Linear Collider positron source helical undulator

    Directory of Open Access Journals (Sweden)

    D. J. Scott

    2007-03-01

    Full Text Available A comparison of possible undulator designs for the International Linear Collider positron source has resulted in a superconducting bifilar wire design being selected. After a comprehensive paper study and fabrication of the two preeminent designs, the superconducting undulator was chosen instead of the permanent magnet alternative. This was because of its superior performance in terms of magnetic field strength and quality, operational flexibility, risk of radiation damage, ease in achieving the required vacuum, and cost. The superconducting undulator design will now be developed into a complete system design for the full 200 m long magnet that is required.

  11. Proceedings of the 2. International Linear Collider Test-beam workshop - LCTW'09

    Energy Technology Data Exchange (ETDEWEB)

    Wormser, G.; Poeschl, R.; Takeshi, M.; Yu, J.; Hauptman, J.; Jeans, D.; Velthuis, J.; Repond, J.; Stanitzki, M.; Chefdeville, M.; Pauletta, G.; Hauptman, J.; Kulis, S.; Charpy, A.; Rivera, R.; Turchetti, M.; Vos, M.; Dehmelt, K.; Settles, R.; Decotigny, D.; Killenberg, M.; Haas, D.; Gaede, F.; Graf, N.; Wing, M.; Gaede, F.; Karstensen, S.; Meyners, N.; Hast, C.; Vrba, V.; Takeshita, T.; Kawagoe, K.; Linssen, L.; Ramberg, E.; Demarteau, M.; Fisk, H.E.; Savoy-Navarro, A.; Videau, H.; Boudry, V.; Hauptman, J.; Lipton, R.; Nelson, T.

    2009-07-01

    At this workshop detector and simulation experts have described and discussed the necessary ILC (International Linear Collider) detector research and development program in view of its need for test beams. This workshop has provided an opportunity to evaluate the capabilities and shortcomings of existing facilities in the context of planned test beam activities. This document gathers together the slides of the presentations. The presentations have been classified into 4 topics: -) plans of sub-detectors - calorimetry, silicon and gaseous tracking, -) data acquisition, -) test beam facilities, and -) resources and infrastructure for future test beams

  12. Proposal of the Next Incarnation of Accelerator Test Facility at KEK for the International Linear Collider

    CERN Document Server

    Hayano, Hitoshi; Angal-Kalinin, Deepa; Appleby, Robert; Araki, Sakae; Bambade, Philip; Bane, Karl Leopold Freitag; Blair, Grahame A; Boogert, Stewart Takashi; Boorman, Gary; Brachmann, Axel; Braun, Hans Heinrich; Burrows, P N; Carter, John; Choi Jae Young; Christian, Glenn B; Danagulyan, S; Delerue, Nicolas; Driouichi, Chafik; Gao, Jie; Grishanov, Boris I; Gronberg, Jeff; Higashi, Yasuo; Himel, Thomas; Honda, Yosuke; Howell, David Francis; Iwashita, Yoshihisa; Jones, James; Kalinin, Alexander; Kanazawa, Ken Ichi; Kang Heung Sik; Kim Eun San; Kim Sang Hee; Kubo, Kiyoshi; Kumada, Masayuki; Kume, T; Kuriki, Masao; Kuroda, Shigeru; Lyapin, A; Liu Wan Ming; Logatchev, P V; Malton, Stephen; Markiewicz, Thomas W; Masuzawa, Mika; Mihara, Takanori; Molloy, Stephen; Mtingwa, S; Naito, Takashi; Napoly, Olivier; Nelson, Janice; Okugi, Toshiyuki; Payet, Jacques; Pei Guo Xi; Phinney, Nan; Pivi, M T F; Podgorny, Fedor; Price, Michael T; Raubenheimer, Tor O; Reichold, Armin; Ross, Marc; Ruland, Robert; Sanuki, Tomoyuki; Schulte, Daniel; Seryi, Andrei; Soo Ko In; Spencer, Cherrill M; Suehara, Taikan; Sugahara, Ryuhei; Takahashi, Takeshi; Tauchi, Toshiaki; Telnov, Valery I; Tenenbaum, P G; Terunuma, Nobuhiro; Toge, Nobu; Torrence, Eric; Urakawa, Junji; Urner, David; Vogel, Vladimir; Walker, Nicholas J; Wang Jiu Qing; White, Glen; Woodley, Mark; Yamaoka, Hiroshi; Yokoya, Kaoru; Yun Huang Jung; Zimmermann, Frank

    2005-01-01

    The realization of the International Linear Collider (ILC) will require the ability to create and reliably maintain nanometer size beams. The ATF damping ring is the unique facility where ILC emittancies are possible. In this paper we present and evaluate the proposal to create a final focus facility at the ATF which, using compact final focus optics and an ILC-like bunch train, would be capable of achieving 35nm beam size. Such a facility would enable the development of beam diagnostics and tuning methods, as well as the training of young accelerator physicists.

  13. An L-Band Polarized Electron PWT Photoinjector for the International Linear Collider (ILC)

    CERN Document Server

    Yu, David; Chen Ping; Lundquist, Martin; Luo, Yan; Smirnov, Alexei Yu

    2005-01-01

    A multi-cell, standing-wave, L-band, p-mode, plane-wave-transformer (PWT) photoinjector with an integrated photocathode in a novel linac structure is proposed by DULY Research Inc. as a polarized electron source. The PWT photoinjector is capable of operation in ultra high vacuum and moderate field gradient. Expected performance of an L-band polarized electron PWT injector operating under the parameters for the International Linear Collider is presented. The projected normalized transverse rms emittance is an order of magnitude lower than that produced with a polarized electron dc gun followed by subharmonic bunchers.

  14. Proposal of the Next Incarnation of Accelerator Test Facility at KEK for the International Linear Collider

    Energy Technology Data Exchange (ETDEWEB)

    Araki, S.; Hayano, H.; Higashi, Y.; Honda, Y.; Kanazawa, K.; Kubo, K.; Kume, T.; Kuriki, M.; Kuroda, S.; Masuzawa, M.; Naito, T.; Okugi, T.; Sugahara, R.; Takahashi, T.; Tauchi, T.; Terunuma, N.; Toge, N.; Urakawa, J.; Vogel, V.; Yamaoka, H.; Yokoya, K.; /KEK, Tsukuba /Beijing, Inst. High Energy Phys. /Novosibirsk, IYF /Daresbury /CERN /Hiroshima

    2005-05-27

    To reach design luminosity, the International Linear Collider (ILC) must be able to create and reliably maintain nanometer size beams. The ATF damping ring is the unique facility where ILC emittances are possible. In this paper we present and evaluate the proposal to create a final focus facility at the ATF which, using compact final focus optics and an ILC-like bunch train, would be capable of achieving 37 nm beam size. Such a facility would enable the development of beam diagnostics and tuning methods, as well as the training of young accelerator physicists.

  15. Improving biomedical information retrieval by linear combinations of different query expansion techniques.

    Science.gov (United States)

    Abdulla, Ahmed AbdoAziz Ahmed; Lin, Hongfei; Xu, Bo; Banbhrani, Santosh Kumar

    2016-07-25

    Biomedical literature retrieval is becoming increasingly complex, and there is a fundamental need for advanced information retrieval systems. Information Retrieval (IR) programs scour unstructured materials such as text documents in large reserves of data that are usually stored on computers. IR is related to the representation, storage, and organization of information items, as well as to access. In IR one of the main problems is to determine which documents are relevant and which are not to the user's needs. Under the current regime, users cannot precisely construct queries in an accurate way to retrieve particular pieces of data from large reserves of data. Basic information retrieval systems are producing low-quality search results. In our proposed system for this paper we present a new technique to refine Information Retrieval searches to better represent the user's information need in order to enhance the performance of information retrieval by using different query expansion techniques and apply a linear combinations between them, where the combinations was linearly between two expansion results at one time. Query expansions expand the search query, for example, by finding synonyms and reweighting original terms. They provide significantly more focused, particularized search results than do basic search queries. The retrieval performance is measured by some variants of MAP (Mean Average Precision) and according to our experimental results, the combination of best results of query expansion is enhanced the retrieved documents and outperforms our baseline by 21.06 %, even it outperforms a previous study by 7.12 %. We propose several query expansion techniques and their combinations (linearly) to make user queries more cognizable to search engines and to produce higher-quality search results.

  16. DCal: A custom integrated circuit for calorimetry at the International Linear Collider

    Energy Technology Data Exchange (ETDEWEB)

    Hoff, James R.; Mekkaoui, Abderrazek; Yarema, Ray; /Fermilab; Drake, Gary; Repond, Jose; /Argonne

    2005-10-01

    A research and development collaboration has been started with the goal of producing a prototype hadron calorimeter section for the purpose of proving the Particle Flow Algorithm concept for the International Linear Collider. Given the unique requirements of a Particle Flow Algorithm calorimeter, custom readout electronics must be developed to service these detectors. This paper introduces the DCal or Digital Calorimetry Chip, a custom integrated circuit developed in a 0.25um CMOS process specifically for this International Linear Collider project. The DCal is capable of handling 64 channels, producing a 1-bit Digital-to-Analog conversion of the input (i.e. hit/no hit). It maintains a 24-bit timestamp and is capable of operating either in an externally triggered mode or in a self-triggered mode. Moreover, it is capable of operating either with or without a pipeline delay. Finally, in order to permit the testing of different calorimeter technologies, its analog front end is capable of servicing Particle Flow Algorithm calorimeters made from either Resistive Plate Chambers or Gaseous Electron Multipliers.

  17. A speed estimation unit for induction motors based on adaptive linear combiner

    Energy Technology Data Exchange (ETDEWEB)

    Marei, Mostafa I.; Shaaban, Mostafa F.; El-Sattar, Ahmed A. [Department of Electrical Power and Machines, Faculty of Engineering, Ain Shams University, Cairo 11517 (Egypt)

    2009-07-15

    This paper presents a new induction motor speed estimation technique, which can estimate the rotor resistance as well, from the measured voltage and current signals. Moreover, the paper utilizes a novel adaptive linear combiner (ADALINE) structure for speed and rotor resistance estimations. This structure can deal with the multi-output systems and it is called MO-ADALINE. The model of the induction motor is arranged in a linear form, in the stationary reference frame, to cope with the proposed speed estimator. There are many advantages of the proposed unit such as wide speed range capability, immunity against harmonics of measured waveforms, and precise estimation of the speed and the rotor resistance at different dynamic changes. Different types of induction motor drive systems are used to evaluate the dynamic performance and to examine the accuracy of the proposed unit for speed and rotor resistance estimation. (author)

  18. Coupling field maps of combined function bending magnets to linear optics for the SESAME storage ring

    CERN Document Server

    Milanese, A

    2013-01-01

    This note provides several analyses of the combined function bending magnets of the SESAME storage ring. The objective is to develop tools to couple the magnetic design to the linear optics specifications. Such tools can be used to carry out a 3D field optimization, at the design phase and following magnetic measurements, in particular in order to fine tune the end shims on the poles. The analyses take as input field maps on the midplane, which are then processed in different ways to obtain linear transfer matrices for the optics, in the horizontal and vertical planes. Some peculiarities of this kind of magnet are also highlighted, for example, the slight variation of gradient along the arc. For convenience, the relative codes and scripts are included in the appendix.

  19. Predictive inference for best linear combination of biomarkers subject to limits of detection.

    Science.gov (United States)

    Coolen-Maturi, Tahani

    2017-08-15

    Measuring the accuracy of diagnostic tests is crucial in many application areas including medicine, machine learning and credit scoring. The receiver operating characteristic (ROC) curve is a useful tool to assess the ability of a diagnostic test to discriminate between two classes or groups. In practice, multiple diagnostic tests or biomarkers are combined to improve diagnostic accuracy. Often, biomarker measurements are undetectable either below or above the so-called limits of detection (LoD). In this paper, nonparametric predictive inference (NPI) for best linear combination of two or more biomarkers subject to limits of detection is presented. NPI is a frequentist statistical method that is explicitly aimed at using few modelling assumptions, enabled through the use of lower and upper probabilities to quantify uncertainty. The NPI lower and upper bounds for the ROC curve subject to limits of detection are derived, where the objective function to maximize is the area under the ROC curve. In addition, the paper discusses the effect of restriction on the linear combination's coefficients on the analysis. Examples are provided to illustrate the proposed method. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

  20. Arrhythmia recognition and classification using combined linear and nonlinear features of ECG signals.

    Science.gov (United States)

    Elhaj, Fatin A; Salim, Naomie; Harris, Arief R; Swee, Tan Tian; Ahmed, Taqwa

    2016-04-01

    Arrhythmia is a cardiac condition caused by abnormal electrical activity of the heart, and an electrocardiogram (ECG) is the non-invasive method used to detect arrhythmias or heart abnormalities. Due to the presence of noise, the non-stationary nature of the ECG signal (i.e. the changing morphology of the ECG signal with respect to time) and the irregularity of the heartbeat, physicians face difficulties in the diagnosis of arrhythmias. The computer-aided analysis of ECG results assists physicians to detect cardiovascular diseases. The development of many existing arrhythmia systems has depended on the findings from linear experiments on ECG data which achieve high performance on noise-free data. However, nonlinear experiments characterize the ECG signal more effectively sense, extract hidden information in the ECG signal, and achieve good performance under noisy conditions. This paper investigates the representation ability of linear and nonlinear features and proposes a combination of such features in order to improve the classification of ECG data. In this study, five types of beat classes of arrhythmia as recommended by the Association for Advancement of Medical Instrumentation are analyzed: non-ectopic beats (N), supra-ventricular ectopic beats (S), ventricular ectopic beats (V), fusion beats (F) and unclassifiable and paced beats (U). The characterization ability of nonlinear features such as high order statistics and cumulants and nonlinear feature reduction methods such as independent component analysis are combined with linear features, namely, the principal component analysis of discrete wavelet transform coefficients. The features are tested for their ability to differentiate different classes of data using different classifiers, namely, the support vector machine and neural network methods with tenfold cross-validation. Our proposed method is able to classify the N, S, V, F and U arrhythmia classes with high accuracy (98.91%) using a combined support

  1. Axial displacement of external and internal implant-abutment connection evaluated by linear mixed model analysis.

    Science.gov (United States)

    Seol, Hyon-Woo; Heo, Seong-Joo; Koak, Jai-Young; Kim, Seong-Kyun; Kim, Shin-Koo

    2015-01-01

    To analyze the axial displacement of external and internal implant-abutment connection after cyclic loading. Three groups of external abutments (Ext group), an internal tapered one-piece-type abutment (Int-1 group), and an internal tapered two-piece-type abutment (Int-2 group) were prepared. Cyclic loading was applied to implant-abutment assemblies at 150 N with a frequency of 3 Hz. The amount of axial displacement, the Periotest values (PTVs), and the removal torque values(RTVs) were measured. Both a repeated measures analysis of variance and pattern analysis based on the linear mixed model were used for statistical analysis. Scanning electron microscopy (SEM) was used to evaluate the surface of the implant-abutment connection. The mean axial displacements after 1,000,000 cycles were 0.6 μm in the Ext group, 3.7 μm in the Int-1 group, and 9.0 μm in the Int-2 group. Pattern analysis revealed a breakpoint at 171 cycles. The Ext group showed no declining pattern, and the Int-1 group showed no declining pattern after the breakpoint (171 cycles). However, the Int-2 group experienced continuous axial displacement. After cyclic loading, the PTV decreased in the Int-2 group, and the RTV decreased in all groups. SEM imaging revealed surface wear in all groups. Axial displacement and surface wear occurred in all groups. The PTVs remained stable, but the RTVs decreased after cyclic loading. Based on linear mixed model analysis, the Ext and Int-1 groups' axial displacements plateaued after little cyclic loading. The Int-2 group's rate of axial displacement slowed after 100,000 cycles.

  2. Lobatto and Radau positive quadrature formulas for linear combinations of Jacobi polynomials

    CERN Document Server

    Bustamante, Jorge; Martíez-Cruz, Reinaldo

    2012-01-01

    For a given $\\theta\\in (-1,1)$, we find out all parameters $\\alpha,\\beta\\in \\{0,1\\}$ such that, there exists a linear combination of Jacobi polynomials $J_{n+1}^{(\\alpha,\\beta)}(x)-C J_{n}^{(\\alpha,\\beta)}(x)$ which generates a Lobatto (Radau) positive quadrature formula of degree of exactness \\textcolor{red}{$2n+2$ ($2n+1$)} and contains the point $\\theta$ as a node. These positive quadratures are very useful in studying problems in one-sided polynomial $L_1$ approximation.

  3. Internal pilots for a class of linear mixed models with Gaussian and compound symmetric data.

    Science.gov (United States)

    Gurka, Matthew J; Coffey, Christopher S; Muller, Keith E

    2007-09-30

    An internal pilot design uses interim sample size analysis, without interim data analysis, to adjust the final number of observations. The approach helps to choose a sample size sufficiently large (to achieve the statistical power desired), but not too large (which would waste money and time). We report on recent research in cerebral vascular tortuosity (curvature in three dimensions) which would benefit greatly from internal pilots due to uncertainty in the parameters of the covariance matrix used for study planning. Unfortunately, observations correlated across the four regions of the brain and small sample sizes preclude using existing methods. However, as in a wide range of medical imaging studies, tortuosity data have no missing or mistimed data, a factorial within-subject design, the same between-subject design for all responses, and a Gaussian distribution with compound symmetry. For such restricted models, we extend exact, small sample univariate methods for internal pilots to linear mixed models with any between-subject design (not just two groups). Planning a new tortuosity study illustrates how the new methods help to avoid sample sizes that are too small or too large while still controlling the type I error rate.

  4. Adaptive Linear and Normalized Combination of Radial Basis Function Networks for Function Approximation and Regression

    Directory of Open Access Journals (Sweden)

    Yunfeng Wu

    2014-01-01

    Full Text Available This paper presents a novel adaptive linear and normalized combination (ALNC method that can be used to combine the component radial basis function networks (RBFNs to implement better function approximation and regression tasks. The optimization of the fusion weights is obtained by solving a constrained quadratic programming problem. According to the instantaneous errors generated by the component RBFNs, the ALNC is able to perform the selective ensemble of multiple leaners by adaptively adjusting the fusion weights from one instance to another. The results of the experiments on eight synthetic function approximation and six benchmark regression data sets show that the ALNC method can effectively help the ensemble system achieve a higher accuracy (measured in terms of mean-squared error and the better fidelity (characterized by normalized correlation coefficient of approximation, in relation to the popular simple average, weighted average, and the Bagging methods.

  5. A linearization approach for the model-based analysis of combined aggregate and individual patient data.

    Science.gov (United States)

    Ravva, Patanjali; Karlsson, Mats O; French, Jonathan L

    2014-04-30

    The application of model-based meta-analysis in drug development has gained prominence recently, particularly for characterizing dose-response relationships and quantifying treatment effect sizes of competitor drugs. The models are typically nonlinear in nature and involve covariates to explain the heterogeneity in summary-level literature (or aggregate data (AD)). Inferring individual patient-level relationships from these nonlinear meta-analysis models leads to aggregation bias. Individual patient-level data (IPD) are indeed required to characterize patient-level relationships but too often this information is limited. Since combined analyses of AD and IPD allow advantage of the information they share to be taken, the models developed for AD must be derived from IPD models; in the case of linear models, the solution is a closed form, while for nonlinear models, closed form solutions do not exist. Here, we propose a linearization method based on a second order Taylor series approximation for fitting models to AD alone or combined AD and IPD. The application of this method is illustrated by an analysis of a continuous landmark endpoint, i.e., change from baseline in HbA1c at week 12, from 18 clinical trials evaluating the effects of DPP-4 inhibitors on hyperglycemia in diabetic patients. The performance of this method is demonstrated by a simulation study where the effects of varying the degree of nonlinearity and of heterogeneity in covariates (as assessed by the ratio of between-trial to within-trial variability) were studied. A dose-response relationship using an Emax model with linear and nonlinear effects of covariates on the emax parameter was used to simulate data. The simulation results showed that when an IPD model is simply used for modeling AD, the bias in the emax parameter estimate increased noticeably with an increasing degree of nonlinearity in the model, with respect to covariates. When using an appropriately derived AD model, the linearization

  6. Information transfer through stochastic transmission of a linear combination of rates.

    Science.gov (United States)

    Smyrnakis, Ioannis; Smirnakis, Stelios

    2013-09-01

    In this work, the Shannon information transfer rate due to the transmission of a linear combination of the firing rates of a number of afferent neurons is examined. The transmission of this linear combination (transfer statistic) takes place through a stochastic firing process, while a rate code is assumed. Constraints are imposed on the transmission process by the requirement that the coefficient of variation for the transfer statistic is small and by the relative variance of the individual terms in the calculation of the statistic. In the regime of no noise or signal correlations among the input neurons, simulations suggest that information transfer for fixed overall input is favored when there are few high-firing neurons, as opposed to more lower-firing neurons. Signal correlations among low-firing neurons can result in aggregates of high firing rates, improving in this way information transfer and calculational robustness. Under reasonable rate code assumptions, information transfer rates obtained are of the order 3 to 10 bit/sec.

  7. Investigation into electron cloud effects in the International Linear Collider positron damping ring

    Directory of Open Access Journals (Sweden)

    J. A. Crittenden

    2014-03-01

    Full Text Available We report modeling results for electron cloud buildup and instability in the International Linear Collider positron damping ring. Updated optics, wiggler magnets, and vacuum chamber designs have recently been developed for the 5 GeV, 3.2-km racetrack layout. An analysis of the synchrotron radiation profile around the ring has been performed, including the effects of diffuse and specular photon scattering on the interior surfaces of the vacuum chamber. The results provide input to the cloud buildup simulations for the various magnetic field regions of the ring. The modeled cloud densities thus obtained are used in the instability threshold calculations. We conclude that the mitigation techniques employed in this model will suffice to allow operation of the damping ring at the design operational specifications.

  8. Beam Delivery System Dogleg Design and Integration for the International Linear Collider

    CERN Document Server

    Jones, J

    2010-01-01

    It is proposed to investigate the option of moving the positron source to the end of the main linac as a part of the central integration in the International Linear Collider(ILC) project. The positron source incorporates an undulator at the end of the main linac and the photons generated in the undulator are transported to the target, located at a distance of around 400 m. The dogleg design has been optimised to provide the required transverse offset at the location of the target and to give minimum emittance growth at 500 GeV. The design of the dogleg, the layout changes and the tolerances on beam tuning as a result of locating this dogleg in the beginning of the beam delivery system (BDS) are presented.

  9. Investigation into electron cloud effects in the International Linear Collider positron damping ring

    Energy Technology Data Exchange (ETDEWEB)

    Crittenden, J.A.; Conway, J.; Dugan, G.F.; Palmer, M.A.; Rubin, D.L.; Shanks, J.; Sonnad, K.G.; Boon, L.; Harkay, K.; Ishibashi, T.; Furman, M.A.; Guiducci, S.; Pivi, M.T.F.; Wang, L.; Crittenden, J.A.; Conway, J.; Dugan, G.F.; Palmer, M.A.; Rubin, D.L.; Shanks, J.; Sonnad, K.G.; Boon, L.; Harkay, K.; Ishibashi, T.; Furman, M.A.; Guiducci, S.; Pivi, M.T.F.; Wang, L.

    2014-02-28

    We report modeling results for electron cloud buildup and instability in the International Linear Collider positron damping ring. Updated optics, wiggler magnets, and vacuum chamber designs have recently been developed for the 5 GeV, 3.2-km racetrack layout. An analysis of the synchrotron radiation profile around the ring has been performed, including the effects of diffuse and specular photon scattering on the interior surfaces of the vacuum chamber. The results provide input to the cloud buildup simulations for the various magnetic field regions of the ring. The modeled cloud densities thus obtained are used in the instability threshold calculations. We conclude that the mitigation techniques employed in this model will suffice to allow operation of the damping ring at the design operational specifications

  10. Monte-Carlo-based studies of a polarized positron source for International Linear Collider (ILC)

    Science.gov (United States)

    Dollan, Ralph; Laihem, Karim; Schälicke, Andreas

    2006-04-01

    The full exploitation of the physics potential of an International Linear Collider (ILC) requires the development of a polarized positron beam. New concepts of polarized positron sources are based on the development of circularly polarized photon sources. The polarized photons create electron-positron pairs in a thin target and transfer their polarization state to the outgoing leptons. To achieve a high level of positron polarization the understanding of the production mechanisms in the target is crucial. Therefore, a general framework for the simulation of polarized processes with GEANT4 is under development. In this contribution the current status of the project and its application to a study of the positron production process for the ILC is presented.

  11. Combined Policies and Ideologies in an American International School

    Science.gov (United States)

    Ramalho, Elizabeth Murakami

    2007-01-01

    Immersed in host countries around the globe, American international schools serve about a quarter of a million Americans. These schools can often be perceived as representatives of U.S. schools in the international setting. This study has a twofold purpose: to introduce students to the philosophy, policies, and practices of American schools…

  12. The International Linear Collider Technical Design Report - Volume 3.II: Accelerator Baseline Design

    CERN Document Server

    Adolphsen, Chris; Barish, Barry; Buesser, Karsten; Burrows, Philip; Carwardine, John; Clark, Jeffrey; Durand, Helene Mainaud; Dugan, Gerry; Elsen, Eckhard; Enomoto, Atsushi; Foster, Brian; Fukuda, Shigeki; Gai, Wei; Gastal, Martin; Geng, Rongli; Ginsburg, Camille; Guiducci, Susanna; Harrison, Mike; Hayano, Hitoshi; Kershaw, Keith; Kubo, Kiyoshi; Kuchler, Victor; List, Benno; Liu, Wanming; Michizono, Shinichiro; Nantista, Christopher; Osborne, John; Palmer, Mark; Paterson, James McEwan; Peterson, Thomas; Phinney, Nan; Pierini, Paolo; Ross, Marc; Rubin, David; Seryi, Andrei; Sheppard, John; Solyak, Nikolay; Stapnes, Steinar; Tauchi, Toshiaki; Toge, Nobu; Walker, Nicholas; Yamamoto, Akira; Yokoya, Kaoru

    2013-01-01

    The International Linear Collider Technical Design Report (TDR) describes in four volumes the physics case and the design of a 500 GeV centre-of-mass energy linear electron-positron collider based on superconducting radio-frequency technology using Niobium cavities as the accelerating structures. The accelerator can be extended to 1 TeV and also run as a Higgs factory at around 250 GeV and on the Z0 pole. A comprehensive value estimate of the accelerator is give, together with associated uncertainties. It is shown that no significant technical issues remain to be solved. Once a site is selected and the necessary site-dependent engineering is carried out, construction can begin immediately. The TDR also gives baseline documentation for two high-performance detectors that can share the ILC luminosity by being moved into and out of the beam line in a "push-pull" configuration. These detectors, ILD and SiD, are described in detail. They form the basis for a world-class experimental programme that promises to incr...

  13. Design optimization of the International Linear Collider Final Focus System with a long L*

    CERN Document Server

    Plassard, Fabien

    This Master's Thesis work has been done in the Aerospace Engineering master's programme framework and carried out at the European Organization for Nuclear Research (CERN). It was conducted under the 500 GeV e-e+ International Linear Collider (ILC) study and focused on the design and performance optimization of the Final Focus System (FFS). The purpose of the final focus system of the future linear colliders (ILC and CLIC) is to demagnify the beam to the required transverse size at the interaction point (IP). The FFS is designed for a flat-beam in a compact way based on a local chromaticity correction which corrects both horizontal and vertical chromaticities simultaneously. An alternative FFS configuration based on the traditional scheme with two dedicated chromatic correction sections for horizontal and vertical chromaticities and a long L * option has been developed. A longer free space between the last quadrupole and the IP allows to place the last quadrupole on a stable ground, with fewer engineering ...

  14. The International Linear Collider Technical Design Report - Volume 3.I: Accelerator \\& in the Technical Design Phase

    Energy Technology Data Exchange (ETDEWEB)

    Adolphsen, Chris [SLAC National Accelerator Lab., Menlo Park, CA (United States); et al.

    2013-06-26

    The International Linear Collider Technical Design Report (TDR) describes in four volumes the physics case and the design of a 500 GeV centre-of-mass energy linear electron-positron collider based on superconducting radio-frequency technology using Niobium cavities as the accelerating structures. The accelerator can be extended to 1 TeV and also run as a Higgs factory at around 250 GeV and on the Z0 pole. A comprehensive value estimate of the accelerator is give, together with associated uncertainties. It is shown that no significant technical issues remain to be solved. Once a site is selected and the necessary site-dependent engineering is carried out, construction can begin immediately. The TDR also gives baseline documentation for two high-performance detectors that can share the ILC luminosity by being moved into and out of the beam line in a "push-pull" configuration. These detectors, ILD and SiD, are described in detail. They form the basis for a world-class experimental programme that promises to increase significantly our understanding of the fundamental processes that govern the evolution of the Universe.

  15. The International Linear Collider Technical Design Report - Volume 1: Executive Summary

    Energy Technology Data Exchange (ETDEWEB)

    Behnke, Ties [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Brau, James E. [Univ. of Oregon, Eugene, OR (United States); Foster, Brian [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Fuster, Juan [Univ. of Valencia (Spain); Harrison, Mike [Brookhaven National Lab. (BNL), Upton, NY (United States); Paterson, James McEwan [SLAC National Accelerator Lab., Menlo Park, CA (United States); Peskin, Michael [SLAC National Accelerator Lab., Menlo Park, CA (United States); Stanitzki, Marcel [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Walker, Nicholas [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Yamamoto, Hitoshi [Tohoku Univ., Sendai (Japan)

    2013-06-26

    The International Linear Collider Technical Design Report (TDR) describes in four volumes the physics case and the design of a 500 GeV centre-of-mass energy linear electron-positron collider based on superconducting radio-frequency technology using Niobium cavities as the accelerating structures. The accelerator can be extended to 1 TeV and also run as a Higgs factory at around 250 GeV and on the Z0 pole. A comprehensive value estimate of the accelerator is give, together with associated uncertainties. It is shown that no significant technical issues remain to be solved. Once a site is selected and the necessary site-dependent engineering is carried out, construction can begin immediately. The TDR also gives baseline documentation for two high-performance detectors that can share the ILC luminosity by being moved into and out of the beam line in a "push-pull" configuration. These detectors, ILD and SiD, are described in detail. They form the basis for a world-class experimental programme that promises to increase significantly our understanding of the fundamental processes that govern the evolution of the Universe.

  16. The International Linear Collider Technical Design Report - Volume 3.II: Accelerator Baseline Design

    Energy Technology Data Exchange (ETDEWEB)

    Adolphsen, Chris [SLAC National Accelerator Lab., Menlo Park, CA (United States); et al.

    2013-06-26

    The International Linear Collider Technical Design Report (TDR) describes in four volumes the physics case and the design of a 500 GeV centre-of-mass energy linear electron-positron collider based on superconducting radio-frequency technology using Niobium cavities as the accelerating structures. The accelerator can be extended to 1 TeV and also run as a Higgs factory at around 250 GeV and on the Z0 pole. A comprehensive value estimate of the accelerator is give, together with associated uncertainties. It is shown that no significant technical issues remain to be solved. Once a site is selected and the necessary site-dependent engineering is carried out, construction can begin immediately. The TDR also gives baseline documentation for two high-performance detectors that can share the ILC luminosity by being moved into and out of the beam line in a "push-pull" configuration. These detectors, ILD and SiD, are described in detail. They form the basis for a world-class experimental programme that promises to increase significantly our understanding of the fundamental processes that govern the evolution of the Universe.

  17. Precise and fast beam energy measurement at the international linear collider

    Energy Technology Data Exchange (ETDEWEB)

    Viti, Michele

    2010-02-15

    The international Linear Collider (ILC) is an electron-positron collider with a center-of-mass energy between 200 and 500 GeV and a peak luminosity of 2 . 10{sup 34} cm{sup -2}s{sup -1}. For the physics program at this machine, an excellent bunch-by-bunch control of the beam energy is mandatory. Several techniques are foreseen to be implemented at the ILC in order to achieve this request. Energy spectrometers upstream and downstream of the electron/positron interaction point were proposed and the present default option for the upstream spectrometer is a beam position monitor based (BPM-based) spectrometer. In 2006/2007, a prototype of such a device was commissioned at the End Station A beam line at the Stanford Linear Accelerator Center (SLAC) in order to study performance and reliability. In addition, a novel method based on laser Compton backscattering has been proposed, since as proved at the Large Electron-Positron Collider (LEP) and the Stanford Linear Collider (SLC), complementary methods are necessary to cross-check the results of the BPM-based spectrometer. In this thesis, an overview of the experiment at End Station A is given, with emphasis on the performance of the magnets in the chicane and first energy resolution estimations. Also, the novel Compton backscattering method is discussed in details and found to be very promising. It has the potential to bring the beam energy resolution well below the requirement of {delta}E{sub b}/E{sub b}=10{sup -4}. (orig.)

  18. REVIEW: Internal high linear energy transfer (LET) targeted radiotherapy for cancer

    Science.gov (United States)

    Allen, Barry J.

    2006-07-01

    High linear energy transfer (LET) radiation for internal targeted therapy has been a long time coming on to the medical therapy scene. While fundamental principles were established many decades ago, the clinical implementation has been slow. Localized neutron capture therapy, and more recently systemic targeted alpha therapy, are at the clinical trial stage. What are the attributes of these therapies that have led a band of scientists and clinicians to dedicate so much of their careers? High LET means high energy density, causing double strand breaks in DNA, and short-range radiation, sparing adjacent normal tissues. This targeted approach complements conventional radiotherapy and chemotherapy. Such therapies fail on several fronts. Foremost is the complete lack of progress for the control of primary GBM, the holy grail for cancer therapies. Next is the inability to regress metastatic cancer on a systemic basis. This has been the task of chemotherapy, but palliation is the major application. Finally, there is the inability to inhibit the development of lethal metastatic cancer after successful treatment of the primary cancer. This review charts, from an Australian perspective, the developing role of local and systemic high LET, internal radiation therapy.

  19. Simultaneous removal of metal ions and linear alkylbenzene sulfonate by combined electrochemical and photocatalytic process.

    Science.gov (United States)

    Doan, H D; Saidi, M

    2008-10-30

    Combined electrochemical removal of Zn(++) and Ni(++) and photo-oxidation of linear alkylbenzene sulfonate (LAS) by suspended TiO(2) particles was investigated. The effect of different process variables such as current density, pH and liquid flow rate on the sole electrochemical reduction of metal ions was also evaluated. At pH of 5.0, the removal of Zn(++) increased by 28% with increases in the liquid flux from 0.0021 to 0.0172 m(3)m(-2)s(-1) while the removal of Ni(++) was only enhanced marginally. Under optimum operating conditions used in the present study (liquid flux=0.0172 m(3) m(-2) s(-1), current density=0.166 mA cm(-2), pH 5.0 and in the presence of LAS), Zn(++) and Ni(++) were reduced by 86 and 56%, respectively, over 7h of the sole electrochemical treatment. For the sole photocatalytic treatment of LAS at pH of 5.0, a 60% LAS degradation was obtained. However, the liquid flow rate did not have any considerable effect on the LAS oxidation. Finally, in the combined photocatalytic-electrolytic process, the LAS degradation increased to 76%. Nonetheless, in the combined system the Zn(++) and Ni(++) removal remained at comparable levels to those obtained in the sole electrochemical system.

  20. Linear and Nonlinear Rheology Combined with Dielectric Spectroscopy of Hybrid Polymer Nanocomposites for Semiconductive Applications

    Science.gov (United States)

    Kádár, Roland; Abbasi, Mahdi; Figuli, Roxana; Rigdahl, Mikael; Wilhelm, Manfred

    2017-01-01

    The linear and nonlinear oscillatory shear, extensional and combined rheology-dielectric spectroscopy of hybrid polymer nanocomposites for semiconductive applications were investigated in this study. The main focus was the influence of processing conditions on percolated poly(ethylene-butyl acrylate) (EBA) nanocomposite hybrids containing graphite nanoplatelets (GnP) and carbon black (CB). The rheological response of the samples was interpreted in terms of dispersion properties, filler distortion from processing, filler percolation, as well as the filler orientation and distribution dynamics inside the matrix. Evidence of the influence of dispersion properties was found in linear viscoelastic dynamic frequency sweeps, while the percolation of the nanocomposites was detected in nonlinearities developed in dynamic strain sweeps. Using extensional rheology, hybrid samples with better dispersion properties lead to a more pronounced strain hardening behavior, while samples with a higher volume percentage of fillers caused a drastic reduction in strain hardening. The rheo-dielectric time-dependent response showed that in the case of nanocomposites containing only GnP, the orientation dynamics leads to non-conductive samples. However, in the case of hybrids, the orientation of the GnP could be offset by the dispersing of the CB to bridge the nanoplatelets. The results were interpreted in the framework of a dual PE-BA model, where the fillers would be concentrated mainly in the BA regions. Furthermore, better dispersed hybrids obtained using mixing screws at the expense of filler distortion via extrusion processing history were emphasized through the rheo-dielectric tests. PMID:28336857

  1. Phase-locking and coherent power combining of broadband linearly chirped optical waves.

    Science.gov (United States)

    Satyan, Naresh; Vasilyev, Arseny; Rakuljic, George; White, Jeffrey O; Yariv, Amnon

    2012-11-05

    We propose, analyze and demonstrate the optoelectronic phase-locking of optical waves whose frequencies are chirped continuously and rapidly with time. The optical waves are derived from a common optoelectronic swept-frequency laser based on a semiconductor laser in a negative feedback loop, with a precisely linear frequency chirp of 400 GHz in 2 ms. In contrast to monochromatic waves, a differential delay between two linearly chirped optical waves results in a mutual frequency difference, and an acoustooptic frequency shifter is therefore used to phase-lock the two waves. We demonstrate and characterize homodyne and heterodyne optical phase-locked loops with rapidly chirped waves, and show the ability to precisely control the phase of the chirped optical waveform using a digital electronic oscillator. A loop bandwidth of ~ 60 kHz, and a residual phase error variance of locking of two optical paths to a common master waveform, and the ability to electronically control the resultant two-element optical phased array. The results of this work enable coherent power combining of high-power fiber amplifiers-where a rapidly chirping seed laser reduces stimulated Brillouin scattering-and electronic beam steering of chirped optical waves.

  2. Fast solution of elliptic partial differential equations using linear combinations of plane waves

    Science.gov (United States)

    Pérez-Jordá, José M.

    2016-02-01

    Given an arbitrary elliptic partial differential equation (PDE), a procedure for obtaining its solution is proposed based on the method of Ritz: the solution is written as a linear combination of plane waves and the coefficients are obtained by variational minimization. The PDE to be solved is cast as a system of linear equations A x =b , where the matrix A is not sparse, which prevents the straightforward application of standard iterative methods in order to solve it. This sparseness problem can be circumvented by means of a recursive bisection approach based on the fast Fourier transform, which makes it possible to implement fast versions of some stationary iterative methods (such as Gauss-Seidel) consuming O (N logN ) memory and executing an iteration in O (N log2N ) time, N being the number of plane waves used. In a similar way, fast versions of Krylov subspace methods and multigrid methods can also be implemented. These procedures are tested on Poisson's equation expressed in adaptive coordinates. It is found that the best results are obtained with the GMRES method using a multigrid preconditioner with Gauss-Seidel relaxation steps.

  3. Linear and Nonlinear Rheology Combined with Dielectric Spectroscopy of Hybrid Polymer Nanocomposites for Semiconductive Applications.

    Science.gov (United States)

    Kádár, Roland; Abbasi, Mahdi; Figuli, Roxana; Rigdahl, Mikael; Wilhelm, Manfred

    2017-01-24

    The linear and nonlinear oscillatory shear, extensional and combined rheology-dielectric spectroscopy of hybrid polymer nanocomposites for semiconductive applications were investigated in this study. The main focus was the influence of processing conditions on percolated poly(ethylene-butyl acrylate) (EBA) nanocomposite hybrids containing graphite nanoplatelets (GnP) and carbon black (CB). The rheological response of the samples was interpreted in terms of dispersion properties, filler distortion from processing, filler percolation, as well as the filler orientation and distribution dynamics inside the matrix. Evidence of the influence of dispersion properties was found in linear viscoelastic dynamic frequency sweeps, while the percolation of the nanocomposites was detected in nonlinearities developed in dynamic strain sweeps. Using extensional rheology, hybrid samples with better dispersion properties lead to a more pronounced strain hardening behavior, while samples with a higher volume percentage of fillers caused a drastic reduction in strain hardening. The rheo-dielectric time-dependent response showed that in the case of nanocomposites containing only GnP, the orientation dynamics leads to non-conductive samples. However, in the case of hybrids, the orientation of the GnP could be offset by the dispersing of the CB to bridge the nanoplatelets. The results were interpreted in the framework of a dual PE-BA model, where the fillers would be concentrated mainly in the BA regions. Furthermore, better dispersed hybrids obtained using mixing screws at the expense of filler distortion via extrusion processing history were emphasized through the rheo-dielectric tests.

  4. Multidisciplinary Inverse Reliability Analysis Based on Collaborative Optimization with Combination of Linear Approximations

    Directory of Open Access Journals (Sweden)

    Xin-Jia Meng

    2015-01-01

    Full Text Available Multidisciplinary reliability is an important part of the reliability-based multidisciplinary design optimization (RBMDO. However, it usually has a considerable amount of calculation. The purpose of this paper is to improve the computational efficiency of multidisciplinary inverse reliability analysis. A multidisciplinary inverse reliability analysis method based on collaborative optimization with combination of linear approximations (CLA-CO is proposed in this paper. In the proposed method, the multidisciplinary reliability assessment problem is first transformed into a problem of most probable failure point (MPP search of inverse reliability, and then the process of searching for MPP of multidisciplinary inverse reliability is performed based on the framework of CLA-CO. This method improves the MPP searching process through two elements. One is treating the discipline analyses as the equality constraints in the subsystem optimization, and the other is using linear approximations corresponding to subsystem responses as the replacement of the consistency equality constraint in system optimization. With these two elements, the proposed method realizes the parallel analysis of each discipline, and it also has a higher computational efficiency. Additionally, there are no difficulties in applying the proposed method to problems with nonnormal distribution variables. One mathematical test problem and an electronic packaging problem are used to demonstrate the effectiveness of the proposed method.

  5. Design of main linac emittance tuning bumps for the Compact Linear Collider and the International Linear Collider

    CERN Document Server

    Eliasson, Peder

    2008-01-01

    The installation of elements in the main linac of future linear colliders can only be done with a limited precision. The inevitable misalignments lead to unacceptable emittance growth. Beam-based alignment, e.g., one-to-one correction, dispersion free steering, or ballistic alignment, is necessary to reduce the emittance growth. In some cases, this is, however, not sufficient. For further reduction of the emittance growth, so-called emittance tuning bumps have to be used. A general strategy for the design of emittance tuning bumps has been developed and tested. Simulations suggest that the method can be conveniently used to understand the weaknesses of existing emittance tuning bumps and to significantly improve their performance in terms of, e.g., emittance reduction capability and convergence speed. An example of an application is the design of ten orthogonal knobs that, according to simulations, can reduce the normalized emittance growth in the Compact Linear Collider (CLIC) main linac from 23.8 to 0.34 nm...

  6. Multiple linear combination (MLC) regression tests for common variants adapted to linkage disequilibrium structure

    Science.gov (United States)

    Yoo, Yun Joo; Sun, Lei; Poirier, Julia G.; Paterson, Andrew D.

    2016-01-01

    ABSTRACT By jointly analyzing multiple variants within a gene, instead of one at a time, gene‐based multiple regression can improve power, robustness, and interpretation in genetic association analysis. We investigate multiple linear combination (MLC) test statistics for analysis of common variants under realistic trait models with linkage disequilibrium (LD) based on HapMap Asian haplotypes. MLC is a directional test that exploits LD structure in a gene to construct clusters of closely correlated variants recoded such that the majority of pairwise correlations are positive. It combines variant effects within the same cluster linearly, and aggregates cluster‐specific effects in a quadratic sum of squares and cross‐products, producing a test statistic with reduced degrees of freedom (df) equal to the number of clusters. By simulation studies of 1000 genes from across the genome, we demonstrate that MLC is a well‐powered and robust choice among existing methods across a broad range of gene structures. Compared to minimum P‐value, variance‐component, and principal‐component methods, the mean power of MLC is never much lower than that of other methods, and can be higher, particularly with multiple causal variants. Moreover, the variation in gene‐specific MLC test size and power across 1000 genes is less than that of other methods, suggesting it is a complementary approach for discovery in genome‐wide analysis. The cluster construction of the MLC test statistics helps reveal within‐gene LD structure, allowing interpretation of clustered variants as haplotypic effects, while multiple regression helps to distinguish direct and indirect associations. PMID:27885705

  7. An Improved Isotropic Periodic Sum Method That Uses Linear Combinations of Basis Potentials

    KAUST Repository

    Takahashi, Kazuaki Z.

    2012-11-13

    Isotropic periodic sum (IPS) is a technique that calculates long-range interactions differently than conventional lattice sum methods. The difference between IPS and lattice sum methods lies in the shape and distribution of remote images for long-range interaction calculations. The images used in lattice sum calculations are identical to those generated from periodic boundary conditions and are discretely positioned at lattice points in space. The images for IPS calculations are "imaginary", which means they do not explicitly exist in a simulation system and are distributed isotropically and periodically around each particle. Two different versions of the original IPS method exist. The IPSn method is applied to calculations for point charges, whereas the IPSp method calculates polar molecules. However, both IPSn and IPSp have their advantages and disadvantages in simulating bulk water or water-vapor interfacial systems. In bulk water systems, the cutoff radius effect of IPSn strongly affects the configuration, whereas IPSp does not provide adequate estimations of water-vapor interfacial systems unless very long cutoff radii are used. To extend the applicability of the IPS technique, an improved IPS method, which has better accuracy in both homogeneous and heterogeneous systems has been developed and named the linear-combination-based isotropic periodic sum (LIPS) method. This improved IPS method uses linear combinations of basis potentials. We performed molecular dynamics (MD) simulations of bulk water and water-vapor interfacial systems to evaluate the accuracy of the LIPS method. For bulk water systems, the LIPS method has better accuracy than IPSn in estimating thermodynamic and configurational properties without the countercharge assumption, which is used for IPSp. For water-vapor interfacial systems, LIPS has better accuracy than IPSp and properly estimates thermodynamic and configurational properties. In conclusion, the LIPS method can successfully estimate

  8. Evaluation of linear dimensional stability of various combinations of dental stone and plaster.

    Science.gov (United States)

    Adegbulugbe, I C; Oderinu, O H; Shaba, O P; Oremosu, O A

    2011-01-01

    It has been observed that due to the cheaper cost of dental plaster compared to dental stone, casts on which most of the dental prostheses and appliances were being fabricated in various laboratories were often mixtures of dental stone and dental plaster in order to reduce production cost. To evaluate the dimensional stability of various combinations of Dental Stone and Dental Plaster mixtures used to make dental casts. Alginate impressions of a master model of truncated metal cones were made and casts were produced by pouring with various combinations of dental stone and dental plaster mixtures. The linear dimensional differences between the inter-abutment distances on the casts were measured with an electronic caliper. One sample t-test and percentage differences were calculated. Dimensional variations for the distances measured using either 50% dental stone or 25% dental stone with plaster were statistically significant (p d" 0.05). Mixture of 75% dental stone and 25% dental plaster produced casts with no statistically significant dimensional variation from the master model (p e" 0.05). A mixture of 75% dental stone and 25% dental plaster could be used for procedures not requiring very accurate replica like mounting of teeth for dental training and for study models.

  9. Einstein observations and the internal dynamics of compact stars: further evidence against non-linear regimes of vortex creep

    Energy Technology Data Exchange (ETDEWEB)

    Horvath, J.E. (Sao Paulo Univ., SP (Brazil). Inst. Astronomico e Geofisico); Benvenuto, O.G. (La Plata Univ. Nacional (Argentina))

    1991-08-15

    We present structural constraints on the Crab and Vela pulsars imposed by the simultaneous assumptions of (a) surface temperatures close to those observed by the Einstein Observatory satellite, and (b) validity of the vortex creep theory in the non-linear regime for interpreting glitch observations and internal features predicted by it. The disagreement between both studies is quantified, thus pointing strongly to the need for linear regimes of creep, as recently suggested, or some alternative picture. (author).

  10. International Linear Collider Reference Design Report Volume 2: Physics at the ILC

    Energy Technology Data Exchange (ETDEWEB)

    Aarons, Gerald; Abe, Toshinori; Abernathy, Jason; Ablikim, Medina; Abramowicz, Halina; Adey, David; Adloff, Catherine; Adolphsen, Chris; Afanaciev, Konstantin; Agapov, Ilya; Ahn, Jung-Keun; Aihara, Hiroaki; Akemoto, Mitsuo; del Carmen Alabau, Maria; Albert, Justin; Albrecht, Hartwig; Albrecht, Michael; Alesini, David; Alexander, Gideon; Alexander, Jim; Allison, Wade; /SLAC /Tokyo U. /Victoria U. /Beijing, Inst. High Energy Phys. /Tel Aviv U. /Birmingham U. /Annecy, LAPP /Minsk, High Energy Phys. Ctr. /DESY /Royal Holloway, U. of London /CERN /Pusan Natl. U. /KEK, Tsukuba /Orsay, LAL /Notre Dame U. /Frascati /Cornell U., Phys. Dept. /Oxford U. /Hefei, CUST /Bangalore, Indian Inst. Sci. /Fermilab

    2011-11-14

    The triumph of 20th century particle physics was the development of the Standard Model and the confirmation of many of its aspects. Experiments determined the particle constituents of ordinary matter, and identified four forces that hold matter together and transform it from one form to another. Particle interactions were found to obey precise laws of relativity and quantum theory. Remarkable features of quantum physics were observed, including the real effects of 'virtual' particles on the visible world. Building on this success, particle physicists are now able to address questions that are even more fundamental, and explore some of the deepest mysteries in science. The scope of these questions is illustrated by this summary from the report Quantum Universe: (1) Are there undiscovered principles of nature; (2) How can we solve the mystery of dark energy; (3) Are there extra dimensions of space; (4) Do all the forces become one; (5) Why are there so many particles; (6) What is dark matter? How can we make it in the laboratory; (7) What are neutrinos telling us; (8) How did the universe begin; and (9) What happened to the antimatter? A worldwide program of particle physics investigations, using multiple approaches, is already underway to explore this compelling scientific landscape. As emphasized in many scientific studies, the International Linear Collider is expected to play a central role in what is likely to be an era of revolutionary advances. Discoveries from the ILC could have breakthrough impact on many of these fundamental questions. Many of the scientific opportunities for the ILC involve the Higgs particle and related new phenomena at Terascale energies. The Standard Model boldly hypothesizes a new form of Terascale energy, called the Higgs field, that permeates the entire universe. Elementary particles acquire mass by interacting with this field. The Higgs field also breaks a fundamental electroweak force into two forces, the electromagnetic

  11. International Linear Collider Reference Design Report Volume 2: Physics at the ILC

    Energy Technology Data Exchange (ETDEWEB)

    Aarons, Gerald; Abe, Toshinori; Abernathy, Jason; Ablikim, Medina; Abramowicz, Halina; Adey, David; Adloff, Catherine; Adolphsen, Chris; Afanaciev, Konstantin; Agapov, Ilya; Ahn, Jung-Keun; Aihara, Hiroaki; Akemoto, Mitsuo; del Carmen Alabau, Maria; Albert, Justin; Albrecht, Hartwig; Albrecht, Michael; Alesini, David; Alexander, Gideon; Alexander, Jim; Allison, Wade; /SLAC /Tokyo U. /Victoria U. /Beijing, Inst. High Energy Phys. /Tel Aviv U. /Birmingham U. /Annecy, LAPP /Minsk, High Energy Phys. Ctr. /DESY /Royal Holloway, U. of London /CERN /Pusan Natl. U. /KEK, Tsukuba /Orsay, LAL /Notre Dame U. /Frascati /Cornell U., Phys. Dept. /Oxford U. /Hefei, CUST /Bangalore, Indian Inst. Sci. /Fermilab

    2011-11-14

    The triumph of 20th century particle physics was the development of the Standard Model and the confirmation of many of its aspects. Experiments determined the particle constituents of ordinary matter, and identified four forces that hold matter together and transform it from one form to another. Particle interactions were found to obey precise laws of relativity and quantum theory. Remarkable features of quantum physics were observed, including the real effects of 'virtual' particles on the visible world. Building on this success, particle physicists are now able to address questions that are even more fundamental, and explore some of the deepest mysteries in science. The scope of these questions is illustrated by this summary from the report Quantum Universe: (1) Are there undiscovered principles of nature; (2) How can we solve the mystery of dark energy; (3) Are there extra dimensions of space; (4) Do all the forces become one; (5) Why are there so many particles; (6) What is dark matter? How can we make it in the laboratory; (7) What are neutrinos telling us; (8) How did the universe begin; and (9) What happened to the antimatter? A worldwide program of particle physics investigations, using multiple approaches, is already underway to explore this compelling scientific landscape. As emphasized in many scientific studies, the International Linear Collider is expected to play a central role in what is likely to be an era of revolutionary advances. Discoveries from the ILC could have breakthrough impact on many of these fundamental questions. Many of the scientific opportunities for the ILC involve the Higgs particle and related new phenomena at Terascale energies. The Standard Model boldly hypothesizes a new form of Terascale energy, called the Higgs field, that permeates the entire universe. Elementary particles acquire mass by interacting with this field. The Higgs field also breaks a fundamental electroweak force into two forces, the electromagnetic

  12. Linear Stability Analysis of Penetrative Convection via Internal Heating in a Ferrofluid Saturated Porous Layer

    Directory of Open Access Journals (Sweden)

    Amit Mahajan

    2017-05-01

    Full Text Available Penetrative convection due to purely internal heating in a horizontal ferrofluid-saturated porous layer is examined by performing linear stability analysis. Four different types of heat supply functions are considered. The Darcy model is used to incorporate the effect of the porous medium. Numerical solutions are obtained by using the Chebyshev pseudospectral method, and the results are discussed for all three boundary conditions: when both boundaries are impermeable and conducting; when both boundaries are conducting with lower boundary impermeable and free upper boundary; and when both boundaries are impermeable with lower boundary conducting and upper with constant heat flux. The effect of the Langevin parameter, width of ferrofluid layer, permeability parameter, and nonlinearity of the fluid magnetization has been observed at the onset of penetrative convection for water- and ester-based ferrofluids. It is seen that the Langevin parameter, width of ferrofluid layer, and permeability parameter have stabilizing effects on the onset of convection, while the nonlinearity of the fluid magnetization advances the onset of convection.

  13. Output Containment Control of Linear Heterogeneous Multi-Agent Systems Using Internal Model Principle.

    Science.gov (United States)

    Zuo, Shan; Song, Yongduan; Lewis, Frank L; Davoudi, Ali

    2017-01-04

    This paper studies the output containment control of linear heterogeneous multi-agent systems, where the system dynamics and even the state dimensions can generally be different. Since the states can have different dimensions, standard results from state containment control do not apply. Therefore, the control objective is to guarantee the convergence of the output of each follower to the dynamic convex hull spanned by the outputs of leaders. This can be achieved by making certain output containment errors go to zero asymptotically. Based on this formulation, two different control protocols, namely, full-state feedback and static output-feedback, are designed based on internal model principles. Sufficient local conditions for the existence of the proposed control protocols are developed in terms of stabilizing the local followers' dynamics and satisfying a certain H∞ criterion. Unified design procedures to solve the proposed two control protocols are presented by formulation and solution of certain local state-feedback and static output-feedback problems, respectively. Numerical simulations are given to validate the proposed control protocols.

  14. Application of International Linear Collider superconducting cavities for acceleration of protons

    Directory of Open Access Journals (Sweden)

    P. N. Ostroumov

    2007-12-01

    Full Text Available Beam acceleration in the International Linear Collider (ILC will be provided by 9-cell 1300 MHz superconducting (SC cavities. The cavities are designed for effective acceleration of charged particles moving with the speed of light and are operated on π-mode to provide a maximum accelerating gradient. A significant research and development effort has been devoted to develop ILC SC technology and its rf system which resulted in excellent performance of ILC cavities. Therefore, the proposed 8-GeV proton driver in Fermilab is based on ILC cavities above ∼1.2  GeV. The efficiency of proton beam acceleration by ILC cavities drops fast for lower velocities and it was proposed to develop squeezed ILC-type (S-ILC cavities operating at 1300 MHz and designed for β_{G}=0.81, geometrical beta, to accelerate protons or H^{-} from ∼420  MeV to 1.2 GeV. This paper discusses the possibility of avoiding the development of new β_{G}=0.81 cavities by operating ILC cavities on 8/9π-mode of standing wave oscillations.

  15. A study with a small prototype TPC for the international linear collider experiment

    Energy Technology Data Exchange (ETDEWEB)

    Ackermann, K. [Max-Planck-Institute for Physics, Munich (Germany); Arai, S. [Tokyo University of Agriculture and Technology, Tokyo (Japan); Arogancia, D.C.; Bacala, A.M. [Mindanao State University, Iligan City (Philippines); Ball, M.; Behnke, T. [DESY, Hamburg (Germany); Bito, H. [Tokyo University of Agriculture and Technology, Tokyo (Japan); Eckardt, V. [Max-Planck-Institute for Physics, Munich (Germany); Fujii, K. [KEK, IPNS, Ibaraki (Japan); Fusayasu, T. [Nagasaki Institute of Applied Science, Nagasaki (Japan); Ghodbane, N. [DESY, Hamburg (Germany); Gooc, H.C Jr. [Mindanao State University, Iligan City (Philippines); Kijima, T. [Tokyo University of Agriculture and Technology, Tokyo (Japan); Hamann, M. [DESY, Hamburg (Germany); Habu, M. [Tokyo University of Agriculture and Technology, Tokyo (Japan); Heuer, R.-D. [Universitaet Hamburg, Hamburg (Germany); Hiramatsu, K. [Kinki University, Osaka (Japan); Ikematsu, K. [KEK, IPNS, Ibaraki (Japan); Kaukher, A. [Universitaet Rostock, Rostock (Germany); Kuroiwa, H. [Saga University, Saga (Japan)

    2010-11-01

    A time projection chamber (TPC) is a strong candidate for the central tracker of the international linear collider (ILC) experiment and we have been conducting a series of cosmic ray experiments under a magnetic field up to 4 T, using a small prototype TPC with a replaceable readout device: multi-wire proportional chamber (MWPC) or gas electron multiplier (GEM). We first confirmed that the MWPC readout could not be a fall-back option of the ILC-TPC under a strong axial magnetic field of 4 T since its spatial resolution suffered severely from the so called ExB effect in the vicinity of the wire planes. The GEM readout, on the other hand, was found to be virtually free from the ExB effect and gave the resolution determined by the transverse diffusion of the drift electrons (diffusion limited). Furthermore, GEMs allow a wider choice of gas mixtures than MWPCs. Among the gases we tried so far a mixture of Ar-CF{sub 4}-isobutane seems promising as the operating gas of the ILC-TPC because of its small diffusion constant especially under a strong magnetic field. We report the spatial resolution obtained with the GEM readout in this gas mixture. Also presented is the spatial resolution of a GEM-based ILC-TPC estimated from the measurement with the prototype.

  16. WIMP search in the mono-photon channel at the international linear collider

    Energy Technology Data Exchange (ETDEWEB)

    Habermehl, Moritz [Deutsches Elektronen-Synchrotron (DESY), Notkestrasse 85, 22607 Hamburg (Germany); Universitaet Hamburg, Institut fuer Experimentalphysik, Luruper Chaussee 149, 22761 Hamburg (Germany); List, Jenny [Deutsches Elektronen-Synchrotron (DESY), Notkestrasse 85, 22607 Hamburg (Germany)

    2016-07-01

    The International Linear Collider (ILC) is a planned electron-positron collider with √(s) tunable from 250 to 500 GeV, with a possible upgrade to 1 TeV. Besides precision measurements of the Higgs boson its physics goals comprise searches for physics beyond the Standard Model, e.g. searches for Dark Matter. This collider search assumes the production of WIMPs in pairs. They are not visible in the detector but the energy carried away can be observed via an additional (''tag'') particle. Photon emission from the initial state leads to the almost model independent signature: e{sup +}e{sup -} → χχγ. As this analysis tests couplings between WIMPs and leptons it is complementary to analogues searches at the LHC. A precise study is facilitated by the clean environment of lepton colliders with small systematics of electroweak backgrounds. While the conceptual feasibility and the sensitivity reach of the ILC have been shown in the past, this talk focusses on the consequences for the detector design. The requirements for the central detector as well as for the instrumentation of the forward region are discussed in the context of the ILD detector concept.

  17. Cryogenic system configuration for the International Linear Collider (ILC) at mountainous site

    Science.gov (United States)

    Nakai, H.; Okamura, T.; Delikaris, D.; Peterson, T.; Yamamoto, A.

    2017-02-01

    The International Linear Collider (ILC) plans to make use of ten cryoplants for its main linacs, each providing 19 kW at 4.5 K equivalent and among of it 3.6 kW at 2 K. Each cryoplant will consist of various cryogenic components such as a 4.5 K refrigerator cold box, a 2 K refrigerator cold box, and helium compressors and so on. In the technical design report (TDR) of the ILC, due to the mountainous topology, almost all cryogenic components would be installed in underground cryogenic caverns next to the main linac tunnels and only cooling towers on surface area. However, we would like to find a more effective and sophisticated configuration of the cryoplant components (cryogenic configuration). Under several constraints of technical, geographical, and environmental points of view, the cryogenic configuration should be considered carefully to satisfy such various conditions. After discussions on this topic conducted at various workshops and conferences, an updated cryogenic configuration is suggested. The proposed updated configuration may affect the total construction cost of the ILC and the entire structure of the ILC conventional facilities. The updated cryogenic configuration is presented and the on-going discussions with the conventional facilities and siting (CFS) colleagues for further improvement of the cryogenic configuration is introduced.

  18. Damage test for International Linear Collider positron generation target at KEKB

    Science.gov (United States)

    Kuriki, M.; Mimashi, T.; Saito, K.; Kikuchi, M.; Kamitani, T.

    2006-07-01

    ILC (International Linear Collider) is aiming to conduct electron-positron collisions at 1 TeV center-of-mass energy. One bunch train will contain up to 2800 3.2 nC bunches with a 308 ns bunch spacing or 5600 1.6 nC bunches with a 154 ns spacing. The bunch-train length will be 0.9 ms. Because of this extremely large amount of beam in a train, serious damage to a positron production target driven by 6 GeV incident electron beam is of concern. As the ILC positron source, several different methods have been proposed. The target hardness is a key point concerning the selection. In this article, we report on a test experiment to examine the target hardness by using a stored electron beam in KEKB HER (High Energy Ring). The project name is IPPAK (ILC Positron Project At KEKB). By manipulating the abort kicker, a condition similar to that of the ILC positron production target can be reproduced. The experiment was carried out on June 29 and 30, 2005. The target was seriously damaged under the heaviest condition (KEKB mode), but the damage was less and nothing for those of the ILC mode. Possible impacts to the ILC positron production scheme are also discussed.

  19. Linear and Nonlinear Rheology Combined with Dielectric Spectroscopy of Hybrid Polymer Nanocomposites for Semiconductive Applications

    Directory of Open Access Journals (Sweden)

    Roland Kádár

    2017-01-01

    Full Text Available The linear and nonlinear oscillatory shear, extensional and combined rheology-dielectric spectroscopy of hybrid polymer nanocomposites for semiconductive applications were investigated in this study. The main focus was the influence of processing conditions on percolated poly(ethylene-butyl acrylate (EBA nanocomposite hybrids containing graphite nanoplatelets (GnP and carbon black (CB. The rheological response of the samples was interpreted in terms of dispersion properties, filler distortion from processing, filler percolation, as well as the filler orientation and distribution dynamics inside the matrix. Evidence of the influence of dispersion properties was found in linear viscoelastic dynamic frequency sweeps, while the percolation of the nanocomposites was detected in nonlinearities developed in dynamic strain sweeps. Using extensional rheology, hybrid samples with better dispersion properties lead to a more pronounced strain hardening behavior, while samples with a higher volume percentage of fillers caused a drastic reduction in strain hardening. The rheo-dielectric time-dependent response showed that in the case of nanocomposites containing only GnP, the orientation dynamics leads to non-conductive samples. However, in the case of hybrids, the orientation of the GnP could be offset by the dispersing of the CB to bridge the nanoplatelets. The results were interpreted in the framework of a dual PE-BA model, where the fillers would be concentrated mainly in the BA regions. Furthermore, better dispersed hybrids obtained using mixing screws at the expense of filler distortion via extrusion processing history were emphasized through the rheo-dielectric tests.

  20. Interpolation across a muffin-tin interstitial using localized linear combinations of spherical waves

    Science.gov (United States)

    Nohara, Yoshiro; Andersen, O. K.

    2016-08-01

    A method for 3D interpolation between hard spheres is described. The function to be interpolated could be the charge density between atoms in condensed matter. Its electrostatic potential is found analytically, and so are various integrals. Periodicity is not required. The interpolation functions are localized structure-adapted linear combinations of spherical waves, the so-called unitary spherical waves (USWs), ψR L(" close=")ɛn)">ɛ ,r , centered at the spheres R , where they have cubic-harmonic character L . Input to the interpolation are the coefficients in the cubic-harmonic expansions of the target function at and slightly outside the spheres; specifically, the values and the three first radial derivatives labeled by d =0 (value) and 1-3 (derivatives). To fit this, we use USWs with four negative energies, ɛ =ɛ1,ɛ2,ɛ3 , and ɛ4. Each interpolation function, ϱd R L(r ), is actually a linear combination of these four sets of USWs with the following properties. (1) It is centered at a specific sphere where it has a specific cubic-harmonic character and radial derivative. (2) Its value and the first three radial derivatives vanish at all other spheres and for all other cubic-harmonic characters, and is therefore highly localized, essentially inside its Voronoi cell. Value-and-derivative (v&d) functions were originally introduced and used by Methfessel [Phys. Rev. B 38, 1537 (1988), 10.1103/PhysRevB.38.1537], but only for the first radial derivative. Explicit expressions are given for the v&d functions and their Coulomb potentials in terms of the USWs at the four energies, plus ɛ0≡0 for the potentials. The coefficients, as well as integrals over the interstitial such as the electrostatic energy, are given entirely in terms of the structure matrix, SR L ,R'L', describing the slopes of the USWs at the five energies and their expansions in Hankel functions. For open structures, additional constraints are installed to pinpoint the interpolated function deep

  1. Measurement of quartic boson couplings at the international linear collider and study of novel particle flow algorithms

    Energy Technology Data Exchange (ETDEWEB)

    Krstonosic, P.

    2008-02-15

    In the absence of the Standard Model Higgs boson the interaction among the gauge bosons becomes strong at high energies ({approx}1 TeV) and influences couplings between them. Trilinear and quartic gauge boson vertices are characterized by set of couplings that are expected to deviate from Standard Model at energies significantly lower then the energy scale of New Physics. Estimation of the precision with which we can measure quartic couplings at International Linear Collider (ILC) is one of two topics covered by this theses. There are several measurement scenarios for quartic couplings. One that we have chosen is weak boson scattering. Since taking of the real data is, unfortunately, still far in the future running options for the machine were also investigated with their impact on the results. Analysis was done in model independent way and precision limits were extracted. Interpretation of the results in terms of possible scenarios beyond Standard Model is then performed by combining accumulated knowledge about all signal processes. One of the key requirements for achieving the results of the measurement in the form that is presented is to reach the detector performance goals. This is possible only with ''Particle Flow'' reconstruction approach. Performance limit of such approach and various contribution to it is discussed in detail. Novel reconstruction algorithm for photon reconstruction is developed, and performance comparison of such concept with more traditional approaches is done. (orig.)

  2. Spin transport and polarimetry in the beam delivery system of the international linear collider

    Energy Technology Data Exchange (ETDEWEB)

    Beckmann, M.; Vauth, A.; Vormwald, B. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Hamburg Univ. (Germany). Inst. fuer Experimentalphysik; List, J. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2014-05-15

    Polarised electron and positron beams are key ingredients to the physics programme of future linear colliders. Due to the chiral nature of weak interactions in the Standard Model - and possibly beyond - the knowledge of the luminosity-weighted average beam polarisation at the e{sup +}e{sup -} interaction point is of similar importance as the knowledge of the luminosity and has to be controlled to permille-level precision in order to fully exploit the physics potential. The current concept to reach this challenging goal combines measurements from Laser-Compton polarimeters before and after the interaction point with measurements at the interaction point. A key element for this enterprise is the understanding of spin-transport effects between the polarimeters and the interaction point as well as collision effects. We show that without collisions, the polarimeters can be cross-calibrated to 0.1 %, and we discuss in detail the impact of collision effects and beam parameters on the polarisation value relevant for the interpretation of the e{sup +}e{sup -} collision data.

  3. Spin Transport and Polarimetry in the Beam Delivery System of the International Linear Collider

    CERN Document Server

    Beckmann, Moritz; Vauth, Annika; Vormwald, Benedikt

    2014-01-01

    Polarised electron and positron beams are key ingredients to the physics programme of future linear colliders. Due to the chiral nature of weak interactions in the Standard Model - and possibly beyond - the knowledge of the luminosity-weighted average beam polarisation at the $e^+e^-$ interaction point is of similar importance as the knowledge of the luminosity and has to be controlled to permille-level precision in order to fully exploit the physics potential. The current concept to reach this challenging goal combines measurements from Laser-Compton polarimeters before and after the interaction point with measurements at the interaction point. A key element for this enterprise is the understanding of spin-transport effects between the polarimeters and the interaction point as well as collision effects. We show that without collisions, the polarimeters can be cross-calibrated to 0.1 %, and we discuss in detail the impact of collision effects and beam parameters on the polarisation value relevant for the inte...

  4. PERFORMANCE COMPARISON OF A LINEARLY COMBINED ORDERED-STATISTIC DETECTORS UNDER POSTDETECTION INTEGRATION AND NONHOMOGENEOUS SITUATIONS

    Institute of Scientific and Technical Information of China (English)

    Mohamed Bakry El_Mashade

    2006-01-01

    Several Constant False Alarm Rate (CFAR) architectures, where radar systems often employ them to automatically adapt the detection threshold to the local background noise or clutter power in an attempt to maintain an approximately constant rate of false alarm, have been recently proposed to estimate the unknown noise power level. Since the Ordered-Statistics (OS) based algorithm has some advantages over the Cell-Averaging (CA) technique, we are concerned here with this type of CFAR detectors. The Linearly Combined Ordered-Statistic (LCOS) processor, which sets threshold by processing a weighted ordered range samples within finite moving window, may actually perform somewhat better than the conventional OS detector.Our objective in this paper is to analyze the LCOS processor along with the conventional OS scheme for the case where the radar receiver incorporates a postdetection integrator amongst its contents and where the operating environments contain a number of secondary interfering targets along with the primary target of concern and the two target types fluctuate in accordance with the Swerling Ⅱ fluctuation model and to compare their performances under various operating conditions.

  5. Nonlinear combination parametric resonance of axially accelerating viscoelastic strings constituted by the standard linear solid model

    Institute of Scientific and Technical Information of China (English)

    LIM; C.W.

    2010-01-01

    Nonlinear combination parametric resonance is investigated for an axially accelerating viscoelastic string.The governing equation of in-planar motion of the string is established by introducing a coordinate transform in the Eulerian equation of a string with moving boundaries.The string under investigation is constituted by the standard linear solid model in which the material,not partial,time derivative was used.The governing equation leads to the Mote model for transverse vibration by omitting the longitudinal component and higher order terms.The Kirchhoff model is derived from the Mote model by replacing the tension with the averaged tension over the string.The two models are respectively analyzed via the method of multiple scales for principal parametric resonance.The amplitudes and the existence conditions of steady-state response and its stability can be numerically determined.Numerical calculations demonstrate the effects of the string material parameters,the initial tension,and the axial speed fluctuation amplitude.The outcomes of the two models are qualitatively and quantitatively compared.

  6. Electron momentum spectroscopy and linear combination of atomic orbitals calculation of bulk Na sub 2 O

    CERN Document Server

    Mikajlo, E A; Ford, M J

    2003-01-01

    This paper presents an experimental measurement of the electronic structure of Na sub 2 O in the solid phase using electron momentum spectroscopy and compares the results with ab initio calculations performed within the linear combination of atomic orbitals (LCAO) approximation. While Hartree-Fock (HF) can reproduce elastic properties we find it overestimates splitting of the oxygen valence bands by around 30% and the width of the O 2p band by a factor of 2. Our experimental values are 15.85 +- 0.2 and 0.6 +- 0.2 eV for these two quantities, respectively. Density functional methods are significantly better, with the hybrid functional PBE0 predicting the oxygen bandgap to within the experimental error. PBE0 also gives the best estimate of the Na core level energies. In contrast, HF performs best for the splitting between the oxygen and sodium bands. Our experimental values of 32.85 +- 0.2 and 27.45 +- 0.2 eV for the Na 2p-Na 2s and O 2p-Na 2p splittings agree well with previous measurements. Distribution of el...

  7. Design of a reaction field using a linear-combination-based isotropic periodic sum method.

    Science.gov (United States)

    Takahashi, Kazuaki Z

    2014-04-30

    In our previous study (Takahashi et al., J. Chem. Theory Comput. 2012, 8, 4503), we developed the linear-combination-based isotropic periodic sum (LIPS) method. The LIPS method is based on the extended isotropic periodic sum theory that produces a ubiquitous interaction potential function to estimate homogeneous and heterogeneous systems. The LIPS theory also provides the procedure to design a periodic reaction field. To demonstrate this, in the present work, a novel reaction field of the LIPS method was developed. The novel reaction field was labeled LIPS-SW, because it provides an interaction potential function with a shape that resembles that of the switch function method. To evaluate the ability of the LIPS-SW method to describe in homogeneous and heterogeneous systems, we carried out molecular dynamics (MD) simulations of bulk water and water-vapor interfacial systems using the LIPS-SW method. The results of these simulations show that the LIPS-SW method gives higher accuracy than the conventional interaction potential function of the LIPS method. The accuracy of simulating water-vapor interfacial systems was greatly improved, while that of bulk water systems was maintained using the LIPS-SW method. We conclude that the LIPS-SW method shows great potential for high-accuracy, high-performance computing to allow large scale MD simulations. © 2014 Wiley Periodicals, Inc.

  8. Combined SERS and flow linear dichroism approach to monitoring the interaction of pharmaceuticals with their target

    Science.gov (United States)

    Ianoul, Anatoli I.; Fleury, Fabrice; Duval, Olivier; Jardillier, Jean-Claude; Alix, Alain J.; Nabiev, Igor R.

    1999-04-01

    Surface-Enhanced Raman Scattering (SERS) spectroscopy and Flow Linear Dichroism (FLD) technique have been employed to study the anticancer agent fagaronine and its derivative ethoxidine - double inhibitors of DNA topoisomerases I and II. Cooperative use of two methods permitted (i) to determine the molecular determinants of the drug-DNA interactions; (ii) to monitor in real time the process of topo I inhibition by these anticancer agents. FLD technique allowed us to identify the mode of drug interactions with the DNA as a 'major groove intercalation' and to determine orientation of the drugs chromophores within the complexes. Using SERS spectroscopy we have determined the drugs molecular determinants interacting with the DNA. FLD was also used for real time monitoring of the process of sc DNA relaxation by topo I and of inhibition of relaxation with the pharmaceuticals. Ethoxidine was found to exhibit the same activity of inhibition of sc DNA relaxation as fagaronine at the 10-fold less concentration. The proposed SERS-FLD combined approach demonstrates the new perspectives for screening new pharmaceuticals due to its relative simplicity and low expense, high sensitivity and selectivity, and, finally, possibility of real-time monitoring of the structure-function correlation within the series of drug derivatives.

  9. Combining linear interpolation with extrapolation methods in range-separated ensemble density-functional theory

    CERN Document Server

    Senjean, Bruno; Alam, Md Mehboob; Knecht, Stefan; Fromager, Emmanuel

    2015-01-01

    The combination of a recently proposed linear interpolation method (LIM) [Senjean et al., Phys. Rev. A 92, 012518 (2015)], which enables the calculation of weight-independent excitation energies in range-separated ensemble density-functional approximations, with the extrapolation scheme of Savin [J. Chem. Phys. 140, 18A509 (2014)] is presented in this work. It is shown that LIM excitation energies vary quadratically with the inverse of the range-separation parameter mu when the latter is large. As a result, the extrapolation scheme, which is usually applied to long-range interacting energies, can be adapted straightforwardly to LIM. This extrapolated LIM (ELIM) has been tested on a small test set consisting of He, Be, H2 and HeH+. Relatively accurate results have been obtained for the first singlet excitation energies with the typical mu=0.4 value. The improvement of LIM after extrapolation is remarkable, in particular for the doubly-excited 2^1Sigma+g state in the stretched H2 molecule. Three-state ensemble ...

  10. Score-moment combined linear discrimination analysis (SMC-LDA) as an improved discrimination method.

    Science.gov (United States)

    Han, Jintae; Chung, Hoeil; Han, Sung-Hwan; Yoon, Moon-Young

    2007-01-01

    A new discrimination method called the score-moment combined linear discrimination analysis (SMC-LDA) has been developed and its performance has been evaluated using three practical spectroscopic datasets. The key concept of SMC-LDA was to use not only the score from principal component analysis (PCA), but also the moment of the spectrum, as inputs for LDA to improve discrimination. Along with conventional score, moment is used in spectroscopic fields as an effective alternative for spectral feature representation. Three different approaches were considered. Initially, the score generated from PCA was projected onto a two-dimensional feature space by maximizing Fisher's criterion function (conventional PCA-LDA). Next, the same procedure was performed using only moment. Finally, both score and moment were utilized simultaneously for LDA. To evaluate discrimination performances, three different spectroscopic datasets were employed: (1) infrared (IR) spectra of normal and malignant stomach tissue, (2) near-infrared (NIR) spectra of diesel and light gas oil (LGO) and (3) Raman spectra of Chinese and Korean ginseng. For each case, the best discrimination results were achieved when both score and moment were used for LDA (SMC-LDA). Since the spectral representation character of moment was different from that of score, inclusion of both score and moment for LDA provided more diversified and descriptive information.

  11. Spin transport at the international linear collider and its impact on the measurement of polarization

    Energy Technology Data Exchange (ETDEWEB)

    Beckmann, Moritz

    2013-12-15

    At the planned International Linear Collider (ILC), the longitudinal beam polarization needs to be determined with an unprecedented precision. For that purpose, the beam delivery systems (BDS) are equipped with two laser Compton polarimeters each, which are foreseen to achieve a systematic uncertainty of {<=} 0.25 %. The polarimeters are located 1.6 km upstream and 150 m downstream of the e{sup +}e{sup -} interaction point (IP). The average luminosity-weighted longitudinal polarization P{sup lumi}{sub z}, which is the decisive quantity for the experiments, has to be determined from these measurements with the best possible precision. Therefore, a detailed understanding of the spin transport in the BDS is mandatory to estimate how precise the longitudinal polarization at the IP is known from the polarimeter measurements. The envisaged precision for the propagation of the measurement value is {<=} 0.1 %. This thesis scrutinizes the spin transport in view of the achievable precision. A detailed beamline simulation for the BDS has been developed, including the simulation of the beam-beam collisions at the IP. The following factors which might limit the achievable precision is investigated: a variation of the beam parameters, the beam alignment precision at the polarimeters and the IP, the bunch rotation at the IP, the detector magnets, the beam-beam collisions, the emission of synchrotron radiation and misalignments of the beamline elements. In absence of collisions, a precision of 0.085% on the propagation of the measured longitudinal polarization has been found achievable. This result however depends mainly on the presumed precisions for the parallel alignment of the beam at the polarimeters and for the alignment of polarization vector. In presence of collisions, the measurement at the downstream polarimeter depends strongly on the intensity of the collision and the size of the polarimeter laser spot. Therefore, a more detailed study of the laser-bunch interaction is

  12. Interim report on the Global Design Effort Global International Linear Collider (ILC) R&D

    Energy Technology Data Exchange (ETDEWEB)

    Harrison, M.

    2011-04-30

    The International Linear Collider: A Technical Progress Report marks the halfway point towards the Global Design Effort fulfilling its mandate to follow up the ILC Reference Design Report with a more optimised Technical Design Report (TDR) by the end of 2012. The TDR will be based on much of the work reported here and will contain all the elements needed to propose the ILC to collaborating governments, including a technical design and implementation plan that are realistic and have been better optimised for performance, cost and risk. We are on track to develop detailed plans for the ILC, such that once results from the Large Hadron Collider (LHC) at CERN establish the main science goals and parameters of the next machine, we will be in good position to make a strong proposal for this new major global project in particle physics. The two overriding issues for the ILC R&D programme are to demonstrate that the technical requirements for the accelerator are achievable with practical technologies, and that the ambitious physics goals can be addressed by realistic ILC detectors. This GDE interim report documents the impressive progress on the accelerator technologies that can make the ILC a reality. It highlights results of the technological demonstrations that are giving the community increased confidence that we will be ready to proceed with an ILC project following the TDR. The companion detector and physics report document likewise demonstrates how detector designs can meet the ambitious and detailed physics goals set out by the ILC Steering Committee. LHC results will likely affect the requirements for the machine design and the detectors, and we are monitoring that very closely, intending to adapt our design as those results become available.

  13. High-frequency normal-mode statistics in shallow water: the combined effect of random surface and internal waves.

    Science.gov (United States)

    Raghukumar, Kaustubha; Colosi, John A

    2015-05-01

    In an earlier article, the statistical properties of mode propagation were studied at a frequency of 1 kHz in a shallow water environment with random sound-speed perturbations from linear internal waves, using a hybrid transport theory and Monte Carlo numerical simulations. Here, the analysis is extended to include the effects of random linear surface waves, in isolation and in combination with internal waves. Mode coupling rates for both surface and internal waves are found to be significant, but strongly dependent on mode number. Mode phase randomization by surface waves is found to be dominated by coupling effects, and therefore a full transport theory treatment of the range evolution of the cross mode coherence matrix is needed. The second-moment of mode amplitudes is calculated using transport theory, thereby providing the mean intensity while the fourth-moment is calculated using Monte Carlo simulations, which provides the scintillation index. The transport theory results for second-moment statistics are shown to closely reproduce Monte Carlo simulations. Both surface waves and internal waves strongly influence the acoustic field fluctuations.

  14. Internal Physical Features of a Land Surface Model Employing a Tangent Linear Model

    Science.gov (United States)

    Yang, Runhua; Cohn, Stephen E.; daSilva, Arlindo; Joiner, Joanna; Houser, Paul R.

    1997-01-01

    The Earth's land surface, including its biomass, is an integral part of the Earth's weather and climate system. Land surface heterogeneity, such as the type and amount of vegetative covering., has a profound effect on local weather variability and therefore on regional variations of the global climate. Surface conditions affect local weather and climate through a number of mechanisms. First, they determine the re-distribution of the net radiative energy received at the surface, through the atmosphere, from the sun. A certain fraction of this energy increases the surface ground temperature, another warms the near-surface atmosphere, and the rest evaporates surface water, which in turn creates clouds and causes precipitation. Second, they determine how much rainfall and snowmelt can be stored in the soil and how much instead runs off into waterways. Finally, surface conditions influence the near-surface concentration and distribution of greenhouse gases such as carbon dioxide. The processes through which these mechanisms interact with the atmosphere can be modeled mathematically, to within some degree of uncertainty, on the basis of underlying physical principles. Such a land surface model provides predictive capability for surface variables including ground temperature, surface humidity, and soil moisture and temperature. This information is important for agriculture and industry, as well as for addressing fundamental scientific questions concerning global and local climate change. In this study we apply a methodology known as tangent linear modeling to help us understand more deeply, the behavior of the Mosaic land surface model, a model that has been developed over the past several years at NASA/GSFC. This methodology allows us to examine, directly and quantitatively, the dependence of prediction errors in land surface variables upon different vegetation conditions. The work also highlights the importance of accurate soil moisture information. Although surface

  15. Studies on the measurement of differential luminosity using Bhabha events at the International Linear Collider

    Energy Technology Data Exchange (ETDEWEB)

    Sailer, Andre Philippe

    2009-04-15

    The International Linear Collider (ILC) is an electron-positron-collider with a variable center-of-mass energy {radical}(2) between 200 and 500 GeV. The small bunch sizes needed to reach the design luminosity of L{sub Peak}=2.10{sup 34} cm{sup -2}s{sup -1} necessary for the physics goals of the ILC, cause the particles to radiate beamstrahlung during the bunch crossings. Beamstrahlung reduces the center-of-mass energy from its nominal value to the effective center-of-mass energy {radical}(2'). The spectrum of the effective center-of-mass energy {radical}(2') is the differential luminosity dL/d{radical}(2'), which has to be known to precisely measure particle masses through threshold scans. The differential luminosity can be measured by using Bhabha events. The real differential luminosity is simulated by the GuineaPig software. The energy spectrum of the Bhabha events is measured by the detector and compared to the energy spectrum of Monte Carlo (MC) Bhabha events with a known differential luminosity given by an approximate parameterization. The parameterization is used to assign each MC event a weight. By re-weighting the events, until the energy spectra from the real and the MC Bhabha events match, the differential luminosity can be measured. The approximate parameterization of the differential luminosity is given by the Circe parameterization introduced by T. Ohl (1997), which does not include the correlation between the particle energies due to beamstrahlung. The Circe parameterization is extended to include the correlation and better describe the differential luminosity. With this new parameterization of the differential luminosity it is possible to predict the observed production cross section of a MC toy particle with a mass of 250 GeV/c{sup 2} to a precision better than 0.2%. Using the re-weighting fit with the extended parameterization also allows the measurement of the beam energy spreads of {sigma}{sub E}=0.0014 for electrons and {sigma

  16. Extracranial internal carotid artery aneurysm treated by combined endovascular - microsurgical techniques

    Directory of Open Access Journals (Sweden)

    Chiriac A.

    2015-09-01

    Full Text Available Extracranial internal carotid artery aneurysms are rare lesions that still represent a challenge from diagnosis and treatment point of view. Giant complex aneurysms of extracranial internal carotid artery are usually completely excluded by surgical approaches. We present a case of a patient with an extracranial internal carotid artery aneurysm treated by a combined treatment, along with a short review of this pathology.

  17. 13th International Conference on Magnetically Levitated Systems and Linear Drives

    Energy Technology Data Exchange (ETDEWEB)

    1993-09-01

    This report contains short papers on research being conducted throughout the world on magnetically levitated systems, mainly consisting of trains, and magnetic linear drives. These papers have been index separately elsewhere on the data base.

  18. The 13th International Conference on Magnetically Levitated Systems and Linear Drives MAGLEV 1993

    Science.gov (United States)

    This report contains short papers on research being conducted throughout the world on magnetically levitated systems, mainly consisting of trains, and magnetic linear drives. These papers have been index separately elsewhere on the data base.

  19. The lay-out of the photon collider at the international linear collider

    Indian Academy of Sciences (India)

    V I Telnov

    2007-12-01

    One of the interaction regions at the linear colliders should be compatible both with + - and , modes of operation. In this paper, the differences in requirements and possible design solutions are discussed.

  20. Simulation studies for a high resolution time projection chamber at the international linear collider

    Energy Technology Data Exchange (ETDEWEB)

    Muennich, A.

    2007-03-26

    The International Linear Collider (ILC) is planned to be the next large accelerator. The ILC will be able to perform high precision measurements only possible at the clean environment of electron positron collisions. In order to reach this high accuracy, the requirements for the detector performance are challenging. Several detector concepts are currently under study. The understanding of the detector and its performance will be crucial to extract the desired physics results from the data. To optimise the detector design, simulation studies are needed. Simulation packages like GEANT4 allow to model the detector geometry and simulate the energy deposit in the different materials. However, the detector response taking into account the transportation of the produced charge to the readout devices and the effects ofthe readout electronics cannot be described in detail. These processes in the detector will change the measured position of the energy deposit relative to the point of origin. The determination of this detector response is the task of detailed simulation studies, which have to be carried out for each subdetector. A high resolution Time Projection Chamber (TPC) with gas amplification based on micro pattern gas detectors, is one of the options for the main tracking system at the ILC. In the present thesis a detailed simulation tool to study the performance of a TPC was developed. Its goal is to find the optimal settings to reach an excellent momentum and spatial resolution. After an introduction to the present status of particle physics and the ILC project with special focus on the TPC as central tracker, the simulation framework is presented. The basic simulation methods and implemented processes are introduced. Within this stand-alone simulation framework each electron produced by primary ionisation is transferred through the gas volume and amplified using Gas Electron Multipliers (GEMs). The output format of the simulation is identical to the raw data from a

  1. Mercury risk assessment combining internal and external exposure methods for a population living near a municipal solid waste incinerator.

    Science.gov (United States)

    Deng, Chunyan; Xie, Han; Ye, Xuejie; Zhang, Haoran; Liu, Maodian; Tong, Yindong; Ou, Langbo; Yuan, Wen; Zhang, Wei; Wang, Xuejun

    2016-12-01

    Risk assessments for human health have been conducted for municipal solid waste incinerators (MSWIs) in many western countries, whereas only a few risk assessments have been performed for MSWIs in developing countries such as China where the use of waste incineration is increasing rapidly. To assess the mercury exposure risks of a population living near the largest MSWI in South China, we combined internal exposure and external exposure assessment with an individual-specific questionnaire. The mercury concentrations in air, soil, and locally collected food around the MSWI were assessed. The total mercury (T-Hg) and methylmercury (MeHg) of 447 blood samples from a control group, residential exposure group, and MSWI workers were measured. The internal and external exposures of the subject population were analyzed. Significant difference in MeHg concentrations was observed between the control group and the exposed group, between the control group and the MSWI workers, and between the exposed group and the MSWI workers (median levels: 0.70 μg/L, 0.81 μg/L, and 1.02 μg/L for the control group, exposed group, and MSWI workers, respectively). The MeHg/T-Hg ratio was 0.51 ± 0.19, 0.59 ± 0.17 and 0.58 ± 0.25, respectively. Multiple linear regression analysis indicated that MeHg concentrations were positively correlated with the gaseous mercury in the air. Combining internal and external exposure assessment showed that the direct contribution of MSWI emissions was minor compared with the dietary contribution. The external and internal exposures were well matched with each other. This study also suggested that an integrated method combining internal and external exposure assessment with an individual-specific questionnaire is feasible to assess the risks for a population living near a MSWI.

  2. Stanford Linear Accelerator Center selects Verity Ultraseek for public and internal Web Sites

    CERN Multimedia

    2004-01-01

    Verity Inc., a provider of enterprise software has announced the latest version of its powerful, downloadable Verity(R) Ultraseek(R) enterprise search engine is being used by the Stanford Linear Accelerator Center, a research facility funded by the U.S. Department of Energy and operated by Stanford University (1/2 page).

  3. Proceedings of the international workshop on next-generation linear colliders

    Energy Technology Data Exchange (ETDEWEB)

    Riordan, M. (ed.)

    1988-12-01

    This report contains papers on the next-generation of linear colliders. The particular areas of discussion are: parameters; beam dynamics and wakefields; damping rings and sources; rf power sources; accelerator structures; instrumentation; final focus; and review of beam-beam interaction.

  4. The combined effects of halo and linear doping effects on the high-frequency and switching performance in ballistic CNTFETs

    Institute of Scientific and Technical Information of China (English)

    Wang Wei; Zhang Lu; Wang Xueying; Wang Zhubing; Zhang Ting; Li Na; Yang Xiao

    2014-01-01

    To overcome short-channel effects (SCEs) in high-performance device applications,a novel structure of CNTFET with a combination of halo and linear doping structure (HL-CNTFET) has been proposed.It has been theoretically investigated by a quantum kinetic model,which is based on two-dimensional non-equilibrium Green's functions solved self-consistently with Poisson's equations.We have studied the effect of halo doping and linear doping structure on static and dynamical performances of HL-CNTFET.It is demonstrated that a halo doping structure can decrease the drain leakage current and improve the on/off current ratio,and that linear doping can improve high-frequency and switching performance.

  5. Fourier, Scattering, and Wavelet Transforms: Applications to Internal Gravity Waves with Comparisons to Linear Tidal Data

    Science.gov (United States)

    2009-10-09

    phenomena came later with Korteweg and de Vries and their description of the KdV solu- tions to the one dimensional problem (see [1]) for a brief... KdV ) equation, which describes the dynamics of weakly- nonlinear dispersive waves, for the internal-waves problem. Under the assumption that the...internal solitary waves are ’long’ and that they are traveling in a ’shallow’ layer (this will be made more precise be- low), the governing ( KdV

  6. Testing the dual-route model of perceived gaze direction: Linear combination of eye and head cues.

    Science.gov (United States)

    Otsuka, Yumiko; Mareschal, Isabelle; Clifford, Colin W G

    2016-06-01

    We have recently proposed a dual-route model of the effect of head orientation on perceived gaze direction (Otsuka, Mareschal, Calder, & Clifford, 2014; Otsuka, Mareschal, & Clifford, 2015), which computes perceived gaze direction as a linear combination of eye orientation and head orientation. By parametrically manipulating eye orientation and head orientation, we tested the adequacy of a linear model to account for the effect of horizontal head orientation on perceived direction of gaze. Here, participants adjusted an on-screen pointer toward the perceived gaze direction in two image conditions: Normal condition and Wollaston condition. Images in the Normal condition included a change in the visible part of the eye along with the change in head orientation, while images in the Wollaston condition were manipulated to have identical eye regions across head orientations. Multiple regression analysis with explanatory variables of eye orientation and head orientation revealed that linear models account for most of the variance both in the Normal condition and in the Wollaston condition. Further, we found no evidence that the model with a nonlinear term explains significantly more variance. Thus, the current study supports the dual-route model that computes the perceived gaze direction as a linear combination of eye orientation and head orientation.

  7. Kernel reconstruction methods for Doppler broadening - Temperature interpolation by linear combination of reference cross sections at optimally chosen temperatures

    Science.gov (United States)

    Ducru, Pablo; Josey, Colin; Dibert, Karia; Sobes, Vladimir; Forget, Benoit; Smith, Kord

    2017-04-01

    This article establishes a new family of methods to perform temperature interpolation of nuclear interactions cross sections, reaction rates, or cross sections times the energy. One of these quantities at temperature T is approximated as a linear combination of quantities at reference temperatures (Tj). The problem is formalized in a cross section independent fashion by considering the kernels of the different operators that convert cross section related quantities from a temperature T0 to a higher temperature T - namely the Doppler broadening operation. Doppler broadening interpolation of nuclear cross sections is thus here performed by reconstructing the kernel of the operation at a given temperature T by means of linear combination of kernels at reference temperatures (Tj). The choice of the L2 metric yields optimal linear interpolation coefficients in the form of the solutions of a linear algebraic system inversion. The optimization of the choice of reference temperatures (Tj) is then undertaken so as to best reconstruct, in the L∞ sense, the kernels over a given temperature range [Tmin ,Tmax ]. The performance of these kernel reconstruction methods is then assessed in light of previous temperature interpolation methods by testing them upon isotope 238U. Temperature-optimized free Doppler kernel reconstruction significantly outperforms all previous interpolation-based methods, achieving 0.1% relative error on temperature interpolation of 238U total cross section over the temperature range [ 300 K , 3000 K ] with only 9 reference temperatures.

  8. Final Report for the UNIVERSITY-BASED DETECTOR RESEARCH AND DEVELOPMENT FOR THE INTERNATIONAL LINEAR COLLIDER

    Energy Technology Data Exchange (ETDEWEB)

    Brau, James E [Univ. of Oregon

    2013-04-22

    The U.S Linear Collider Detector R&D program, supported by the DOE and NSF umbrella grants to the University of Oregon, made significant advances on many critical aspects of the ILC detector program. Progress advanced on vertex detector sensor development, silicon and TPC tracking, calorimetry on candidate technologies, and muon detection, as well as on beamline measurements of luminosity, energy, and polarization.

  9. Fault tolerant linear actuator

    Science.gov (United States)

    Tesar, Delbert

    2004-09-14

    In varying embodiments, the fault tolerant linear actuator of the present invention is a new and improved linear actuator with fault tolerance and positional control that may incorporate velocity summing, force summing, or a combination of the two. In one embodiment, the invention offers a velocity summing arrangement with a differential gear between two prime movers driving a cage, which then drives a linear spindle screw transmission. Other embodiments feature two prime movers driving separate linear spindle screw transmissions, one internal and one external, in a totally concentric and compact integrated module.

  10. Comparison of strategies for combining dynamic linear models with artificial neural networks for detecting diarrhea in slaughter pigs

    DEFF Research Database (Denmark)

    Jensen, Dan Børge; Kristensen, Anders Ringgaard

    2016-01-01

    The drinking behavior of healthy pigs is known to follow predictable diurnal patterns, and these patterns are further known to change in relation to undesired events such as diarrhea. We therefore expect that automatic monitoring of slaughter pig drinking behavior, combined with machine learning......, can provide early and automatic detection of diarrhea. To determine the best approach to achieve this goal, we compared 36 different strategies for combining a multivariate dynamic linear model (DLM) with an artificial neural network (ANN). We used data collected in 16 pens between November 2013...

  11. Experimental study of periodic linear internal waves transform at the shelf edge

    Science.gov (United States)

    Shishkina, Olga; Litvin, Alexander; Vladimirova, Eleonora; Ivanov, Dmitry; Ivanov, Vladlen

    2010-05-01

    The report contains results of the experimental study of the fine structure of hydrophysical processes of internal waves transform in the shelf zone observed within a thin thermocline. A series of experiments was performed in the stratified tank with its overall dimensions L*B*H = 2.15*0.15*0.35 m where the model of the shelf has been installed. The shadowgraph IAB-455 as well as the multidot spatial system of 40 thermocouples were used for distance and contact measurements. Methods of a digital video fixation of shadow pictures of currents in the thermally stratified liquid, as well as methods of the statistical analysis of non-stationary hydrodynamic processes were applied. As a result of the series of experiments it was revealed that interaction of internal waves in the pycnocline with the shelf model leads to transformation of the internal waves, formation of currents of vortical and turbulent character and water mass mixture. The observations concern a case of creation of a package of five periodic internal waves made in the pycnocline by a submerged wave-maker. Acknowledgement: this work is supported through NWO-RFBR Project (Code: 047.017.2006.003).

  12. Study of linearity and internal background for LaBr3(Ce) γ-ray scintillation detector

    Science.gov (United States)

    Lavagno, A.; Gervino, G.; Scarfone, A.

    2013-08-01

    Cerium-doped lanthanum bromide, LaBr3(Ce), crystal is the latest among the scintillation counters and shows same attracting properties for γ spectroscopy that makes it a suitable solution for security, medical, geophysics and high energy physics applications. LaBr3(Ce) exhibits a proportional light yield response to γ-ray energy. Very good linearity was seen up to 2 MeV. LaBr3(Ce) has also relatively high intrinsic radiation background due to naturally occurring 138La and 227Ac radioisotopes. A good use of LaBr3(Ce) needs an accurate determination of the self-activity, particularly when low background is required or when events are collected at very low trigger rates. The impact of internal background on energy resolution and linearity is discussed.

  13. An adaptive linear combiner for on-line tracking of power system harmonics

    Energy Technology Data Exchange (ETDEWEB)

    Dash, P.K.; Swain, D.P. [Regional Engineering Coll., Rourkela (India). Dept. of Electrical Engineering; Liew, A.C. [National Univ. of Singapore (Singapore). Dept. of Electrical Engineering; Rahman, S. [Virginia Polytechnic Inst. and State Univ., VA (United States). Dept. of Electrical Engineering

    1996-11-01

    The paper presents a new approach for the estimation of harmonic components of a power system using a linear adaptive neuron called Adaline. The learning parameters in the proposed neural estimation algorithm are adjusted to force the error between the actual and desired outputs to satisfy a stable difference error equation. The estimator tracks the Fourier coefficients of the signal data corrupted with noise and decaying dc components very accurately. Adaptive tracking of harmonic components of a power system can easily be done using this algorithm. Several numerical tests have been conducted for the adaptive estimation of harmonic components of power system signals mixed with noise and decaying dc components.

  14. Combined Simulation of a Micro Permanent Magnetic Linear Contactless Displacement Sensor

    Directory of Open Access Journals (Sweden)

    Jing Gao

    2010-09-01

    Full Text Available The permanent magnetic linear contactless displacement (PLCD sensor is a new type of displacement sensor operating on the magnetic inductive principle. It has many excellent properties and has already been used for many applications. In this article a Micro-PLCD sensor which can be used for microelectromechanical system (MEMS measurements is designed and simulated with the CST EM STUDIO® software, including building a virtual model, magnetostatic calculations, low frequency calculations, steady current calculations and thermal calculations. The influence of some important parameters such as air gap dimension, working frequency, coil current and eddy currents etc. is studied in depth.

  15. An inverse problem of temperature estimation for the combination of the linear and nonlinear resistances

    Directory of Open Access Journals (Sweden)

    Slavica M. Perovich

    2011-06-01

    Full Text Available The subject of the theoretical analysis presented in this paper is an analytical approach to the temperature estimation, as an inverse problem, for different thermistors – linear resistances structures: series and parallel ones, by the STFT - Special Trans Functions Theory (S.M. Perovich. The mathematical formulae genesis of both cases is given. Some numerical and graphical simulations in MATHEMATICA program have been realized. The estimated temperature intervals for strongly determined values of the equivalent resistances of the nonlinear structures are given, as well.

  16. Combined simulation of a micro permanent magnetic linear contactless displacement sensor.

    Science.gov (United States)

    Gao, Jing; Müller, Wolfgang F O; Greiner, Felix; Eicher, Dirk; Weiland, Thomas; Schlaak, Helmut F

    2010-01-01

    The permanent magnetic linear contactless displacement (PLCD) sensor is a new type of displacement sensor operating on the magnetic inductive principle. It has many excellent properties and has already been used for many applications. In this article a Micro-PLCD sensor which can be used for microelectromechanical system (MEMS) measurements is designed and simulated with the CST EM STUDIO(®) software, including building a virtual model, magnetostatic calculations, low frequency calculations, steady current calculations and thermal calculations. The influence of some important parameters such as air gap dimension, working frequency, coil current and eddy currents etc. is studied in depth.

  17. Optimization of mixed convection in a lid-driven porous square cavity with internal elliptic shape adiabatic block and linearly heated side walls

    Science.gov (United States)

    Munshi, M. Jahirul Haque; Alim, M. A.; Bhuiyan, A. H.; Ali, M.

    2017-06-01

    The physical model considered here is a lid-driven porous square cavity with internal elliptic shape adiabatic block and linearly heated side walls. The top moving wall is well cold and set with uniform velocity. The bottom moving wall heated, linearly heated side walls and inside the elliptic shape adiabatic. The relevant parameters in the present study are Darcy number Da = 10-5-10-3, Grashof number Gr = 103-105, Reynolds number Re = 1-102 and Prandtl number Pr = 0.7. The isotherms are also almost symmetric at small Re with higher Gr (Gr = 105) and Da (Da = 10-3) and natural convection is found to be dominant whereas the isotherms are compressed near the left and bottom walls at higher Re for linearly heated side walls. The solution of these governing equations is obtained numerically with the finite element approach using the Galerkin method of weighted residuals. Results are presented in the form of streamlines, isotherms, Local Nusselt number, average Nusselt number, velocity and temperature for the afore mentioned parameters. The numerical results indicate the strong influence of the mentioned parameters on the flow structure and heat transfer as well as average Nusselt number. An optimum combination of the governing parameters would result in higher heat transfer.

  18. THE OBSERVATION OF INTERNAL MOTION OF LINEAR POLYSTYRENE CHAINS IN CYCLOHEXANE AROUND θ TEMPERATURE

    Institute of Scientific and Technical Information of China (English)

    Jun-fang Li; Yi-jie Lu; Guang-zhao Zhang; Chi Wu

    2008-01-01

    A high molecular weight (Mw=1.85×107) polystyrene (PS) with narrow distribution was prepared by high vacuum anionic polymerization in tetrahydrofuran.By use of dynamic light scattering,the dynamics of PS chains in cyclohexane was studied around the 0 temperature.For the first time,we have observed the internal motion of polymer chains in solutions below the θ temperature by using dynamic light scattering at smaller angles (even qRg<1).

  19. Free Electron Laser for Gamma-Gamma Collider at a Low-Energy Option of International Linear Collider

    Energy Technology Data Exchange (ETDEWEB)

    Saldin, Evgeny; Schneidmiller, Evgeny; Yurkov, Mikhail; /DESY; Seryi, Andrei; /SLAC

    2009-10-30

    Different scenarios of a start-up with International Linear Collider (ILC) are under discussion at the moment in the framework of the Global Design Effort (GDE). One of them assumes construction of the ILC in stages from some minimum CM energy up to final target of 500 GeV CM energy. Gamma-gamma collider with CM energy of 180GeV is considered as a candidate for the first stage of the facility. In this report we present conceptual design of a free electron laser as a source of primary photons for the first stage of ILC.

  20. Ultimate parameters of the photon collider at the international linear collider

    Indian Academy of Sciences (India)

    V I Telnov

    2007-12-01

    At linear colliders, the + - luminosity is limited by beam-collision effects, which determine the required emittances of beams in damping rings (DRs). In collisions at the photon collider, these effects are absent, and so smaller emittances are desirable. In the present damping ring designs, nominal DR parameters correspond to those required for + - collisions. In this note, I would like to stress once again that as soon as we plan the photon collider mode of ILC operation, the damping ring emittances are dictated by the photon collider requirements - namely, they should be as small as possible. This can be achieved by adding more wigglers to the DRs; the incremental cost is easily justified by a considerable potential improvement of the luminosity. No expert analysis exists as of now, but it seems realistic to obtain a factor five increase of the luminosity compared to the `nominal' DR design.

  1. Budgeting and control of the mechanical noise in the International Linear Collider final focus system

    Science.gov (United States)

    Tshilumba, D.; Oriunno, M.; Markiewicz, T.; Collette, C.

    2014-06-01

    In this paper, we present a simplified vibration model of the silicon detector (SiD), where the final doublet (QD0) is captured inside the detector and the penultimate magnet (QF1) is inside the machine tunnel. Ground motion spectra measured at the detector hall at SLAC have been used together with a spectrum of the technical noise on the detector. The model predicts that the maximum level of rms (root mean square) vibration seen by QD0 is well below the capture range of the interaction point (IP) feedback system available in the ILC. With the addition of an active stabilization system on QD0, it is also possible to get closer to the stability requirements of the compact linear collider (CLIC). These results can have important implications for CLIC.

  2. Budgeting and control of the mechanical noise in the International Linear Collider final focus system

    Directory of Open Access Journals (Sweden)

    D. Tshilumba

    2014-06-01

    Full Text Available In this paper, we present a simplified vibration model of the silicon detector (SiD, where the final doublet (QD0 is captured inside the detector and the penultimate magnet (QF1 is inside the machine tunnel. Ground motion spectra measured at the detector hall at SLAC have been used together with a spectrum of the technical noise on the detector. The model predicts that the maximum level of rms (root mean square vibration seen by QD0 is well below the capture range of the interaction point (IP feedback system available in the ILC. With the addition of an active stabilization system on QD0, it is also possible to get closer to the stability requirements of the compact linear collider (CLIC. These results can have important implications for CLIC.

  3. Linear Stability Analysis for Plane-Poiseuille Flow of an Elastoviscoplastic fluid with internal microstructure

    CERN Document Server

    Moyers-Gonzalez, Miguel; Mak, Julian

    2010-01-01

    We study the linear stability of Plane Poiseuille flow of an elastoviscoplastic fluid using a revised version of the model proposed by Putz and Burghelea (Rheol. Acta (2009)48:673-689). The evolution of the microstructure upon a gradual increase of the external forcing is governed by a structural variable (the concentration of solid material elements) which decays smoothly from unity to zero as the stresses are gradually increased beyond the yield point. Stability results are in close conformity with the ones of a pseudo-plastic fluid. Destabilizing effects are related to the presence of an intermediate transition zone where elastic solid elements coexist with fluid elements. This region brings an elastic contribution which does modify the stability of the flow.

  4. An application of locally linear model tree algorithm with combination of feature selection in credit scoring

    Science.gov (United States)

    Siami, Mohammad; Gholamian, Mohammad Reza; Basiri, Javad

    2014-10-01

    Nowadays, credit scoring is one of the most important topics in the banking sector. Credit scoring models have been widely used to facilitate the process of credit assessing. In this paper, an application of the locally linear model tree algorithm (LOLIMOT) was experimented to evaluate the superiority of its performance to predict the customer's credit status. The algorithm is improved with an aim of adjustment by credit scoring domain by means of data fusion and feature selection techniques. Two real world credit data sets - Australian and German - from UCI machine learning database were selected to demonstrate the performance of our new classifier. The analytical results indicate that the improved LOLIMOT significantly increase the prediction accuracy.

  5. Combined photochemical and biological processes for the treatment of linear alkylbenzene sulfonate in water.

    Science.gov (United States)

    Mehrvar, Mehrab; Tabrizi, Gelareh Bankian

    2006-01-01

    In this study, the effects of photochemical pre-treatment (pilot-plant UV/H2O2 process) of linear alkylbenzene sulfonate (LAS) on its subsequent biological treatment were examined. It was observed that the photochemical pre-treatment of the LAS solution did not increase its biodegradability. Moreover, the effects of acclimated microorganisms on the biodegradability of the LAS solution were also studied. It was observed that the acclimated activated sludge increased the biodegradation of the LAS solution. However, due to the presence of some intermediates in the effluent of the photoreactor, the biodegradability of this effluent was less than the biodegradability of the untreated LAS solution with the same concentration of the LAS in the effluent of the photoreactor.

  6. ALGORITHM OF MULTIHARMONIC DISTURBANCE COMPENSATION IN LINEAR SYSTEMS WITH ARBITRARY DELAY: INTERNAL MODEL APPROACH

    Directory of Open Access Journals (Sweden)

    Dmitry N. Gerasimov

    2016-11-01

    Full Text Available Subject of Research. The problem of multiharmonic disturbance compensation for the class of linear time-invariant plants with known parameters and delay is considered. Method. The disturbance is presented as unmeasurable output of linear autonomous model (exosystem with known order and unknown parameters. The problem is resolved with the use of parametrized representation of disturbance designed by means of exosystem state observer and predictor of this state that finally enables applying certainty equivalence principle. In order to remove undesirable influence of delay a modified adaptation algorithm is created. The algorithm is based on augmentation of the plant state vector and generates advanced adjustable parameters for control. As distinct from widespread approaches, the proposed algorithm does not require identification of disturbance parameters and gives the possibility to remove such restrictions as adaptation gain margin and time delay margin. Main Results. Simulation results obtained in MATLAB/Simulink environment are presented to demonstrate the performance of proposed approach. Results illustrate the boundness of all signals in the closed-loop system and complete compensation of harmonic signal. It is shown that the proposed idea makes it possible to increase the adaptation gain for different delays without system stability loss. Practical Relevance. The algorithm of adaptive compensation is recommended for the use in such problems as: the problem of control for active vibration protection devices wherein several dominating harmonics can be taken from the spectrum of vibration signal; the problems of control of robotics systems with periodical behavior; the problems of ship roll compensation; the problems of space plants control in the presence of uncontrollable rotation.

  7. A Hierarchical Generalized Linear Model in Combination with Dispersion Modeling to Improve Sib-Pair Linkage Analysis.

    Science.gov (United States)

    Lee, Woojoo; Kim, Jeonghwan; Lee, Youngjo; Park, Taesung; Suh, Young Ju

    2015-01-01

    We explored a hierarchical generalized linear model (HGLM) in combination with dispersion modeling to improve the sib-pair linkage analysis based on the revised Haseman-Elston regression model for a quantitative trait. A dispersion modeling technique was investigated for sib-pair linkage analysis using simulation studies and real data applications. We considered 4 heterogeneous dispersion settings according to a signal-to-noise ratio (SNR) in the various statistical models based on the Haseman-Elston regression model. Our numerical studies demonstrated that susceptibility loci could be detected well by modeling the dispersion parameter appropriately. In particular, the HGLM had better performance than the linear regression model and the ordinary linear mixed model when the SNR is low, i.e., when substantial noise was present in the data. The study shows that the HGLM in combination with dispersion modeling can be utilized to identify multiple markers showing linkage to familial complex traits accurately. Appropriate dispersion modeling might be more powerful to identify markers closest to the major genes which determine a quantitative trait. © 2015 S. Karger AG, Basel.

  8. Internal transport barrier triggered by non-linear lower hybrid wave deposition under condition of beam-driven toroidal rotation

    Science.gov (United States)

    Gao, Q. D.; Budny, R. V.

    2015-03-01

    By using gyro-Landau fluid transport model (GLF23), time-dependent integrated modeling is carried out using TRANSP to explore the dynamic process of internal transport barrier (ITB) formation in the neutral beam heating discharges. When the current profile is controlled by LHCD (lower hybrid current drive), with appropriate neutral beam injection, the nonlinear interplay between the transport determined gradients in the plasma temperature (Ti,e) and toroidal velocity (Vϕ) and the E×B flow shear (including q-profile) produces transport bifurcations, generating spontaneously a stepwise growing ITB. In the discharge, the constraints imposed by the wave propagation condition causes interplay of the LH driven current distribution with the plasma configuration modification, which constitutes non-linearity in the LH wave deposition. The non-linear effects cause bifurcation in LHCD, generating two distinct quasi-stationary reversed magnetic shear configurations. The change of current profile during the transition period between the two quasi-stationary states results in increase of the E×B shearing flow arising from toroidal rotation. The turbulence transport suppression by sheared E×B flow during the ITB development is analysed, and the temporal evolution of some parameters characterized the plasma confinement is examined. Ample evidence shows that onset of the ITB development is correlated with the enhancement of E×B shearing rate caused by the bifurcation in LHCD. It is suggested that the ITB triggering is associated with the non-linear effects of the LH power deposition.

  9. Combined sodium ion sensitivity in agonist binding and internalization of vasopressin V1b receptors.

    Science.gov (United States)

    Koshimizu, Taka-Aki; Kashiwazaki, Aki; Taniguchi, Junichi

    2016-05-03

    Reducing Na(+) in the extracellular environment may lead to two beneficial effects for increasing agonist binding to cell surface G-protein coupled receptors (GPCRs): reduction of Na(+)-mediated binding block and reduce of receptor internalization. However, such combined effects have not been explored. We used Chinese Hamster Ovary cells expressing vasopressin V1b receptors as a model to explore Na(+) sensitivity in agonist binding and receptor internalization. Under basal conditions, a large fraction of V1b receptors is located intracellularly, and a small fraction is in the plasma membrane. Decreases in external Na(+) increased cell surface [(3)H]AVP binding and decreased receptor internalization. Substitution of Na(+) by Cs(+) or NH4(+) inhibited agonist binding. To suppress receptor internalization, the concentration of NaCl, but not of CsCl, had to be less than 50 mM, due to the high sensitivity of the internalization machinery to Na(+) over Cs(+). Iso-osmotic supplementation of glucose or NH4Cl maintained internalization of the V1b receptor, even in a low-NaCl environment. Moreover, iodide ions, which acted as a counter anion, inhibited V1b agonist binding. In summary, we found external ionic conditions that could increase the presence of high-affinity state receptors at the cell surface with minimum internalization during agonist stimulations.

  10. Predicting Material Weaknesses In Internal Control Systems After The Sarbanes-Oxley Act Using Multiple Criteria Linear Programming And Other Data Mining Approaches

    National Research Council Canada - National Science Library

    Wikil Kwak; Susan Eldridge; Yong Shi; Gang Kou

    2009-01-01

      Our study proposes a multiple criteria linear programming (MCLP) and other data mining methods to predict material weaknesses in a firm's internal control system after the Sarbanes-Oxley Act (SOX) using 2003-2004 U.S. data...

  11. Reducing access times for an endoscopy department by an iterative combination of computer simulation and linear programming.

    Science.gov (United States)

    Joustra, P E; de Wit, J; Struben, V M D; Overbeek, B J H; Fockens, P; Elkhuizen, S G

    2010-03-01

    To reduce the access times of an endoscopy department, we developed an iterative combination of Discrete Event simulation and Integer Linear Programming. We developed the method in the Endoscopy Department of the Academic Medical Center in Amsterdam and compared different scenarios to reduce the access times for the department. The results show that by a more effective allocation of the current capacity, all procedure types will meet their corresponding performance targets in contrast to the current situation. This improvement can be accomplished without requiring additional equipment and staff. Currently, our recommendations are implemented.

  12. Mixing by internal waves quantified using combined PIV/PLIF technique

    Science.gov (United States)

    Dossmann, Y.; Bourget, B.; Brouzet, C.; Dauxois, T.; Joubaud, S.; Odier, P.

    2016-08-01

    We present a novel characterization of mixing events associated with the propagation and overturning of internal waves studied, thanks to the simultaneous use of particle image velocimetry (PIV) and planar laser-induced fluorescence (PLIF) techniques. This combination of techniques had been developed earlier to provide an access to simultaneous velocity and density fields in two-layer stratified flows with interfacial gravity waves. Here, for the first time, we show how it is possible to implement it quantitatively in the case of a continuously stratified fluid where internal waves propagate in the bulk. We explain in details how the calibration of the PLIF data is performed by an iterative procedure, and we describe the precise spatial and temporal synchronizations of the PIV and PLIF measurements. We then validate the whole procedure by characterizing the triadic resonance instability (TRI) of an internal wave mode. Very interestingly, the combined technique is then applied to a precise measurement of the turbulent diffusivity K t associated with mixing events induced by an internal wave mode. Values up to K t = 15 mm2 s-1 are reached when TRI is present (well above the noise of our measurement, typically 1 mm2 s-1), unambiguously confirming that TRI is a potential pathway to turbulent mixing in stratified flows. This work therefore provides a step on the path to new measurements for internal waves.

  13. Linear kinematics at take-off in horses jumping the wall in an international Puissance competition.

    Science.gov (United States)

    Powers, Pippa

    2005-07-01

    Sagittal plane SVHS video recordings (50 Hz) were made of horses jumping the wall at an international Puissance competition. Video sequences were manually digitized and six kinematic variables at take-off were analyzed. Nine horses started the competition with the fence height at 1.80 m, and two horses attempted the fence in the fifth and final round with the fence height at 2.27 m. For successful performances, fence height was correlated with the following take-off variables: vertical velocity of the centre of mass (r = 0.45, p = 0.03); height of centre of mass (r = 0.44, p = 0.04); distance of centre of mass from fence (r = 0.46, p = 0.03); and distance from leading hind limb to centre of mass (r = -0.61, p horses jumping over a Puissance wall. The results should help horse riders and trainers improve performance in Puissance jumping horses, and perhaps help in the early selection of horses with a talent for jumping high fences.

  14. Hyperspectral Small Target Detection by Combining Kernel PCA with Linear Mixture Model

    Institute of Scientific and Technical Information of China (English)

    GUYanfeng; ZHANGYe

    2005-01-01

    In this paper, a kernel-based invariant detection method is proposed for small target detection of hyperspectral images. The method combines Kernel principal component analysis (KPCA) with Iinear mixture model (LMM) together. The LMM is used to describe each pixel in the hyperspectral images as a mixture of target,background and noise. The KPCA is used to build back-ground subspace. Finally, a generalized likelihood ratio test is used to detect whether each pixel in hyperspectral image includes target. The numerical experiments are performed on hyperspectral data with 126 bands collected by Airborne visible/infrared imaging spectrometer (AVIRIS).The experimental results show the effectiveness of the proposed method and prove that this method can commendably overcome spectral variability and sparsity of target in the hyperspectral target detection, and it has great ability to separate target from background.

  15. Robust Management of Combined Heat and Power Systems via Linear Decision Rules

    DEFF Research Database (Denmark)

    Zugno, Marco; Morales González, Juan Miguel; Madsen, Henrik

    2014-01-01

    The heat and power outputs of Combined Heat and Power (CHP) units are jointly constrained. Hence, the optimal management of systems including CHP units is a multicommodity optimization problem. Problems of this type are stochastic, owing to the uncertainty inherent both in the demand for heat...... and in the electricity prices that owners of CHP units receive for the power they sell in the market. In this work, we model the management problem for a coupled heat-and-power system comprising CHP plants, units solely producing heat as well as heat storages. We propose a robust optimization model including unit...... commitment, day-ahead power and heat dispatch as well as real-time re-dispatch (recourse) variables. This model yields a solution that is feasible under any realization of the heat demand within a given uncertainty set. Optimal recourse functions for the real-time operation of the units are approximated via...

  16. Obtaining a linear combination of the principal components of a matrix on quantum computers

    Science.gov (United States)

    Daskin, Ammar

    2016-10-01

    Principal component analysis is a multivariate statistical method frequently used in science and engineering to reduce the dimension of a problem or extract the most significant features from a dataset. In this paper, using a similar notion to the quantum counting, we show how to apply the amplitude amplification together with the phase estimation algorithm to an operator in order to procure the eigenvectors of the operator associated to the eigenvalues defined in the range [ a, b] , where a and b are real and 0 ≤ a ≤ b ≤ 1. This makes possible to obtain a combination of the eigenvectors associated with the largest eigenvalues and so can be used to do principal component analysis on quantum computers.

  17. Combining support vector machines with linear quadratic regulator adaptation for the online design of an automotive active suspension system

    Science.gov (United States)

    Chiou, J.-S.; Liu, M.-T.

    2008-02-01

    As a powerful machine-learning approach to pattern recognition problems, the support vector machine (SVM) is known to easily allow generalization. More importantly, it works very well in a high-dimensional feature space. This paper presents a nonlinear active suspension controller which achieves a high level performance by compensating for actuator dynamics. We use a linear quadratic regulator (LQR) to ensure optimal control of nonlinear systems. An LQR is used to solve the problem of state feedback and an SVM is used to address the question of the estimation and examination of the state. These two are then combined and designed in a way that outputs feedback control. The real-time simulation demonstrates that an active suspension using the combined SVM-LQR controller provides passengers with a much more comfortable ride and better road handling.

  18. Update on coaxial coupling scheme for International Linear Collider-type cavities

    Directory of Open Access Journals (Sweden)

    P. Kneisel

    2010-02-01

    Full Text Available This paper reports on our efforts to develop a flangeable coaxial coupler for both higher order mode and fundamental coupling for nine-cell ILC-type cavities, which were designed in the early 1990’s for pulsed operation with a duty factor less than 1%. The design of the coupler has been done in such a way that the rf magnetic flux B at the flange connection was minimized and only a field of <5  mT would be present for an operation at an accelerating field E_{acc}∼36  MV/m (B∼150  mT in the cavity. Even though we achieved reasonably high Q values at low field, the cavity/coupler combination was limited in the cw mode to only ∼7  MV/m, where a thermally initiated degradation occurred. We believed that this limitation was caused by poor cooling of the shorting plate and inner tube in the coaxial coupler; therefore, we have improved the cooling conditions by initially drilling radial cooling channels every 30 degrees, then every 15 degrees into the shorting plate and eventually removing the “bridges” between the channels. This paper reports on our experiences with the modified coaxial coupler under cw and pulsed conditions.

  19. A Combined MPI-CUDA Parallel Solution of Linear and Nonlinear Poisson-Boltzmann Equation

    Science.gov (United States)

    Colmenares, José; Galizia, Antonella; Ortiz, Jesús; Clematis, Andrea; Rocchia, Walter

    2014-01-01

    The Poisson-Boltzmann equation models the electrostatic potential generated by fixed charges on a polarizable solute immersed in an ionic solution. This approach is often used in computational structural biology to estimate the electrostatic energetic component of the assembly of molecular biological systems. In the last decades, the amount of data concerning proteins and other biological macromolecules has remarkably increased. To fruitfully exploit these data, a huge computational power is needed as well as software tools capable of exploiting it. It is therefore necessary to move towards high performance computing and to develop proper parallel implementations of already existing and of novel algorithms. Nowadays, workstations can provide an amazing computational power: up to 10 TFLOPS on a single machine equipped with multiple CPUs and accelerators such as Intel Xeon Phi or GPU devices. The actual obstacle to the full exploitation of modern heterogeneous resources is efficient parallel coding and porting of software on such architectures. In this paper, we propose the implementation of a full Poisson-Boltzmann solver based on a finite-difference scheme using different and combined parallel schemes and in particular a mixed MPI-CUDA implementation. Results show great speedups when using the two schemes, achieving an 18.9x speedup using three GPUs. PMID:25013789

  20. A combined MPI-CUDA parallel solution of linear and nonlinear Poisson-Boltzmann equation.

    Science.gov (United States)

    Colmenares, José; Galizia, Antonella; Ortiz, Jesús; Clematis, Andrea; Rocchia, Walter

    2014-01-01

    The Poisson-Boltzmann equation models the electrostatic potential generated by fixed charges on a polarizable solute immersed in an ionic solution. This approach is often used in computational structural biology to estimate the electrostatic energetic component of the assembly of molecular biological systems. In the last decades, the amount of data concerning proteins and other biological macromolecules has remarkably increased. To fruitfully exploit these data, a huge computational power is needed as well as software tools capable of exploiting it. It is therefore necessary to move towards high performance computing and to develop proper parallel implementations of already existing and of novel algorithms. Nowadays, workstations can provide an amazing computational power: up to 10 TFLOPS on a single machine equipped with multiple CPUs and accelerators such as Intel Xeon Phi or GPU devices. The actual obstacle to the full exploitation of modern heterogeneous resources is efficient parallel coding and porting of software on such architectures. In this paper, we propose the implementation of a full Poisson-Boltzmann solver based on a finite-difference scheme using different and combined parallel schemes and in particular a mixed MPI-CUDA implementation. Results show great speedups when using the two schemes, achieving an 18.9x speedup using three GPUs.

  1. A Combined MPI-CUDA Parallel Solution of Linear and Nonlinear Poisson-Boltzmann Equation

    Directory of Open Access Journals (Sweden)

    José Colmenares

    2014-01-01

    Full Text Available The Poisson-Boltzmann equation models the electrostatic potential generated by fixed charges on a polarizable solute immersed in an ionic solution. This approach is often used in computational structural biology to estimate the electrostatic energetic component of the assembly of molecular biological systems. In the last decades, the amount of data concerning proteins and other biological macromolecules has remarkably increased. To fruitfully exploit these data, a huge computational power is needed as well as software tools capable of exploiting it. It is therefore necessary to move towards high performance computing and to develop proper parallel implementations of already existing and of novel algorithms. Nowadays, workstations can provide an amazing computational power: up to 10 TFLOPS on a single machine equipped with multiple CPUs and accelerators such as Intel Xeon Phi or GPU devices. The actual obstacle to the full exploitation of modern heterogeneous resources is efficient parallel coding and porting of software on such architectures. In this paper, we propose the implementation of a full Poisson-Boltzmann solver based on a finite-difference scheme using different and combined parallel schemes and in particular a mixed MPI-CUDA implementation. Results show great speedups when using the two schemes, achieving an 18.9x speedup using three GPUs.

  2. Distribución de las transformaciones lineales de los residuos mínimos cuadrados studentizados internamente = Distribution of linear transformations of internally studentized least squares residuals

    Directory of Open Access Journals (Sweden)

    Seppo Pynnönem

    2012-03-01

    that the resulting ratio, U/S, has a distribution that is free of from the nuisance unknown scale parameter. External Studentization refers to a ratio in which the nominator and denominator are independent, while internal Studentization refers to a ratio in which these are dependent. The advantage of the internal Studentization is that typically one can use a single common scale estimator, while in the external Studentization every single residual is scaled by different scale estimator to gain the independence. With normal regression errors the joint distribution of an arbitrary (linearly independent subset of internally Studentized residuals is well documented. However, in some applications a linear combination of internally Studentized residuals may be useful. The boundedness of them is well documented, but the distribution seems not be derived in the literature. This paper contributes to the existing literature by deriving the joint distribution of an arbitrary linear transformation of internally Studentized residuals from ordinary least squares regression with spherical error distribution. All major versions of commonly utilized internally Studentized regression residuals in literature are obtained as special cases of the linear transformation

  3. Distribución de las transformaciones lineales de los residuos mínimos cuadrados studentizados internamente = Distribution of linear transformations of internally studentized least squares residuals

    Directory of Open Access Journals (Sweden)

    Seppo Pynnönen

    2012-12-01

    that the resulting ratio, U/S, has a distribution that is free of from the nuisance unknown scale parameter. External Studentization refers to a ratio in which the nominator and denominator are independent, while internal Studentization refers to a ratio in which these are dependent. The advantage of the internal Studentization is that typically one can use a single common scale estimator, while in the external Studentization every single residual is scaled by different scale estimator to gain the independence. With normal regression errors the joint distribution of an arbitrary (linearly independent subset of internally Studentized residuals is well documented. However, in some applications a linear combination of internally Studentized residuals may be useful. The boundedness of them is well documented, but the distribution seems not be derived in the literature. This paper contributes to the existing literature by deriving the joint distribution of an arbitrary linear transformation of internally Studentized residuals from ordinary least squares regression with spherical error distribution. All major versions of commonly utilized internally Studentized regression residuals in literature are obtained as special cases of the linear transformation

  4. The Effect of Creative Tasks on Electrocardiogram: Using Linear and Nonlinear Features in Combination with Classification Approaches

    Directory of Open Access Journals (Sweden)

    Sahar Zakeri

    2017-02-01

    Full Text Available Objective: Interest in the subject of creativity and its impacts on human life is growing extensively. However, only a few surveys pay attention to the relation between creativity and physiological changes. This paper presents a novel approach to distinguish between creativity states from electrocardiogram signals. Nineteen linear and nonlinear features of the cardiac signal were extracted to detect creativity states. Method: ECG signals of 52 participants were recorded while doing three tasks of Torrance Tests of Creative Thinking (TTCT/ figural B. To remove artifacts, notch filter 50 Hz and Chebyshev II were applied. According to TTCT scores, participants were categorized into the high and low creativity groups: Participants with scores higher than 70 were assigned into the high creativity group and those with scores less than 30 were considered as low creativity group. Some linear and nonlinear features were extracted from the ECGs. Then, Support Vector Machine (SVM and Adaptive Neuro-Fuzzy Inference System (ANFIS were used to classify the groups.Results: Applying the Wilcoxon test, significant differences were observed between rest and each three tasks of creativity. However, better discrimination was performed between rest and the first task. In addition, there were no statistical differences between the second and third task of the test. The results indicated that the SVM effectively detects all the three tasks from the rest, particularly the task 1 and reached the maximum accuracy of 99.63% in the linear analysis. In addition, the high creative group was separated from the low creative group with the accuracy of 98.41%.Conclusion: the combination of SVM classifier with linear features can be useful to show the relation between creativity and physiological changes.

  5. The Effect of Creative Tasks on Electrocardiogram: Using Linear and Nonlinear Features in Combination with Classification Approaches.

    Science.gov (United States)

    Zakeri, Sahar; Abbasi, Ataollah; Goshvarpour, Ateke

    2017-01-01

    Objective: Interest in the subject of creativity and its impacts on human life is growing extensively. However, only a few surveys pay attention to the relation between creativity and physiological changes. This paper presents a novel approach to distinguish between creativity states from electrocardiogram signals. Nineteen linear and nonlinear features of the cardiac signal were extracted to detect creativity states. Method: ECG signals of 52 participants were recorded while doing three tasks of Torrance Tests of Creative Thinking (TTCT/ figural B). To remove artifacts, notch filter 50 Hz and Chebyshev II were applied. According to TTCT scores, participants were categorized into the high and low creativity groups: Participants with scores higher than 70 were assigned into the high creativity group and those with scores less than 30 were considered as low creativity group. Some linear and nonlinear features were extracted from the ECGs. Then, Support Vector Machine (SVM) and Adaptive Neuro-Fuzzy Inference System (ANFIS) were used to classify the groups. Results: Applying the Wilcoxon test, significant differences were observed between rest and each three tasks of creativity. However, better discrimination was performed between rest and the first task. In addition, there were no statistical differences between the second and third task of the test. The results indicated that the SVM effectively detects all the three tasks from the rest, particularly the task 1 and reached the maximum accuracy of 99.63% in the linear analysis. In addition, the high creative group was separated from the low creative group with the accuracy of 98.41%. Conclusion: the combination of SVM classifier with linear features can be useful to show the relation between creativity and physiological changes.

  6. External fixation combined with limited internal fixation in the treatment of pilon tibia fractures

    Directory of Open Access Journals (Sweden)

    Golubović Zoran

    2007-01-01

    Full Text Available Background/Aim. Intraarticular fractures of the tibial plafond (pilon fractures belong to the group of most severe fractures. They are usually caused by high-energy trauma and frequently associated with a marked soft-tissue damage. Surgical treatment has replaced the traditional nonoperative treatment. The aim of this study was to present the results of the treatment of distal tibial intraarticular fracture by the use of internal fixation, as well as the combination of minimal internal fixation and external fixation. Methods. The study included 47 patients with pilon tibia fractures who went through at the Clinic for Orthopedics and Traumatology, School of Medicine, Niš (1995-2004. Within the analyzed group there were 33 (70.2% males and 14 (29.8% females. The patients mean age was 45.8 years. In the first group, which consisted of 22 patients, open reduction and internal fixation of both the tibia and the fibula was performed in the two separate incisions. The second group consisted of 25 patients managed with external fixation by external fixator "Mitković" with limited internal fixation. Besides external fixation, a minimal internal fixation was performed by the use of Kirschner wires and screws. The patients were followed-up inside a 24-months-period. Results. The obtained was a substantially high number of complications after open reduction and internal fixation in the group of patients. There was no difference in a long-term clinical outcome. Postoperative osteitis, as the most severe complication in the management of closed pilon tibia fractures, was not registered in the second group. Conclusion. Considering the results obtained in this study, it can be concluded that external fixation by the "Mitković" external fixator with the minimal internal fixation is a satisfactory method for the treatment of fractures of the tibial plafond causing less complications than internal fixation. .

  7. Attenuated total internal reflection infrared microspectroscopic imaging using a large-radius germanium internal reflection element and a linear array detector.

    Science.gov (United States)

    Patterson, Brian M; Havrilla, George J

    2006-11-01

    The number of techniques and instruments available for Fourier transform infrared (FT-IR) microspectroscopic imaging has grown significantly over the past few years. Attenuated total internal reflectance (ATR) FT-IR microspectroscopy reduces sample preparation time and has simplified the analysis of many difficult samples. FT-IR imaging has become a powerful analytical tool using either a focal plane array or a linear array detector, especially when coupled with a chemometric analysis package. The field of view of the ATR-IR microspectroscopic imaging area can be greatly increased from 300 x 300 microm to 2500 x 2500 microm using a larger internal reflection element of 12.5 mm radius instead of the typical 1.5 mm radius. This gives an area increase of 70x before aberrant effects become too great. Parameters evaluated include the change in penetration depth as a function of beam displacement, measurements of the active area, magnification factor, and change in spatial resolution over the imaging area. Drawbacks such as large file size will also be discussed. This technique has been successfully applied to the FT-IR imaging of polydimethylsiloxane foam cross-sections, latent human fingerprints, and a model inorganic mixture, which demonstrates the usefulness of the method for pharmaceuticals.

  8. The E166 experiment: Development of an undulator-based polarized positron source for the international linear collider

    Indian Academy of Sciences (India)

    J Kovermann; A Stahl; A A Mikhailichenko; D Scott; G A Moortgat-Pick; V Gharibyan; P Pahl; R Pöschl; K P Schüler; K Laihem; S Riemann; A Schälicke; R Dollan; H Kolanoski; T Lohse; T Schweizer; K T McDonald; Y Batygin; V Bharadwaj; G Bower; F-J Decker; C Hast; R Iverson; J C Sheppard; Z Szalata; D Walz; A Weidemann; G Alexander; E Reinherz-Aronis; S Berridge; W Bugg; Y Efrimenko

    2007-12-01

    A longitudinal polarized positron beam is foreseen for the international linear collider (ILC). A proof-of-principle experiment has been performed in the final focus test beam at SLAC to demonstrate the production of polarized positrons for implementation at the ILC. The E166 experiment uses a 1 m long helical undulator in a 46.6 GeV electron beam to produce a few MeV photons with a high degree of circular polarization. These photons are then converted in a thin target to generate longitudinally polarized + and -. The positron polarization is measured using a Compton transmission polarimeter. The data analysis has shown asymmetries in the expected vicinity of 3.4% and ∼ 1% for photons and positrons respectively and the expected positron longitudinal polarization is covering a range from 50% to 90%.

  9. Combined application of the International Classification of Functioning, Disability and Health and the NANDA-International Taxonomy II.

    Science.gov (United States)

    Boldt, Christine; Grill, Eva; Bartholomeyczik, Sabine; Brach, Mirjam; Rauch, Alexandra; Eriks-Hoogland, Inge; Stucki, Gerold

    2010-08-01

    This paper presents a discussion of the conceptual and practical relationships between the International Classification of Functioning, Disability and Health and the NANDA-International Taxonomy II for nursing diagnoses, and their use in nursing practice. The ICF provides a common classification framework for all healthcare professionals, including nurses. Nursing care plans can be broadly based on NANDA-I taxonomies. No published attempt has been made to systematically compare the NANDA-I Taxonomy II to the ICF. The most recently published descriptions of both classifications and a case example presenting the combined use of both classifications. The work was carried out in 2009. There are conceptual commonalities and differences between the ICF and the NANDA-I Taxonomy II. In the case example, the overlap between the ICF categories and NANDA-I nursing diagnoses reflects the fact that the ICF, focusing on functioning and disability, and the NANDA-I Taxonomy II, with its functioning health patterns, are similar in their approaches. The NANDA-I Taxonomy II permits the fulfilment of requirements that are exclusively nursing issues. The application of the ICF is useful for nurses to communicate nursing issues with other healthcare professionals in a common language. For nurses, knowledge shared with other healthcare professionals may contribute to broader understanding of a patient's situation. The ICF and the NANDA-I Taxonomy II should be used in concert by nurses and can complement each other to enhance the quality of clinical team work and nursing practice.

  10. Combination of internal radiation therapy and hyperthermia to treat liver cancer

    Energy Technology Data Exchange (ETDEWEB)

    Grady, E.D.; McLaren, J.; Auda, S.P.; McGinley, P.H.

    1983-09-01

    Sixteen patients were treated for liver cancer (primary and metastatic) by a combination of internal radiation therapy with intra-arterial yttrium 90 microspheres and regional hyperthermia with electromagnetic radiation. Four patients have their liver disease apparently controlled; two had a partial regression of more than 50%; and two had a partial regression of less than 50%. The complications consisted of one case of radiation hepatitis and one of peptic ulcer.

  11. Monitoring international migration flows in Europe. Towards a statistical data base combining data from different sources

    OpenAIRE

    Willekens, F.J.

    1994-01-01

    The paper reviews techniques that have been developed in demography, geography and statistics, and that are useful for bridging the gap between available data on international migration flows and the information required for policy making and research. The basic idea of the paper is that, in order to establish a coherent and consistent data base that contains sufficiently detailed, up-to-date and accurate information, data from several sources should be combined. That raises issues of definit...

  12. Non-linear model reduction and control of molten carbonate fuel cell systems with internal reforming

    Energy Technology Data Exchange (ETDEWEB)

    Sheng, Min

    2007-10-12

    resulting reduced order model is of considerably lower order than the detailed model and requires much less computation time. It is used for the development of a model based control strategy in Chapter 5. The purpose of control is to guarantee a fast and safe dynamic response of the fuel cell system during load changes; an optimal steady state electric efficiency is also desired. Taking both considerations a control strategy with three main loops is designed. The first loop is composed of a master controller that imposed a load change and sets fuel gas, the steam to carbon ratio, air number and cathode gas recycle ratio to their corresponding conditions for optimal steady state electric efficiency. The other two loops are feedback PID controllers that for given temperature limits (maximum temperature and maximum temperature difference) respond by changing the air ratio and steam to carbon ratio around the default sets by the master controller. It turns out that for load changes, the PID controllers can successfully take the maximum temperatures as well as the spatial temperature differences to their desired set-points. In cases, where the maximum temperature and the maximum temperature difference cannot be measured directly, the proposed control scheme has to be combined with a state estimator. A suitable state estimator is developed based on the reduced-order model and the control strategy with the observer shows reasonable results. (orig.)

  13. A Highly Granular Silicon-Tungsten Electromagnetic Calorimeter and Top Quark Production at the International Linear Collider

    CERN Document Server

    Rouëné, J

    2014-01-01

    This thesis deals with two aspects of the International Linear Collider (ILC) which is a project of a linear electron-positron collider of up to at least 500 GeV center of mass energy. The first aspect is the development of a silicon-tungsten electromagnetic calorimeter (SiW-ECAL) for one of the detectors of the ILC. The concept of this detector is driven by the ILC beam specifications and by the Particle Flow Algorithm (PFA). This requires highly granular calorimeter and very compact one with integrated electronics. To prove the capability of the SiW- ECAL a technological prototype has been built and tested in test beam at DESY. The results are presented here, and show, after the calibration procedure a signal over noise ratio of 10, even in the power pulsing mode. The second aspect is the study of one of the important physics channels of the ILC, the top anti-top quark pairs production. The main goal of this study is to determine the precision that we can expect at the ILC on the top coupling with the W bos...

  14. The International Linear Collider Technical Design Report - Volume 3.I: Accelerator R&D in the Technical Design Phase

    CERN Document Server

    Adolphsen, Chris; Barish, Barry; Buesser, Karsten; Burrows, Philip; Carwardine, John; Clark, Jeffrey; Durand, Hélène Mainaud; Dugan, Gerry; Elsen, Eckhard; Enomoto, Atsushi; Foster, Brian; Fukuda, Shigeki; Gai, Wei; Gastal, Martin; Geng, Rongli; Ginsburg, Camille; Guiducci, Susanna; Harrison, Mike; Hayano, Hitoshi; Kershaw, Keith; Kubo, Kiyoshi; Kuchler, Victor; List, Benno; Liu, Wanming; Michizono, Shinichiro; Nantista, Christopher; Osborne, John; Palmer, Mark; Paterson, James McEwan; Peterson, Thomas; Phinney, Nan; Pierini, Paolo; Ross, Marc; Rubin, David; Seryi, Andrei; Sheppard, John; Solyak, Nikolay; Stapnes, Steinar; Tauchi, Toshiaki; Toge, Nobu; Walker, Nicholas; Yamamoto, Akira; Yokoya, Kaoru

    2013-01-01

    The International Linear Collider Technical Design Report (TDR) describes in four volumes the physics case and the design of a 500 GeV centre-of-mass energy linear electron-positron collider based on superconducting radio-frequency technology using Niobium cavities as the accelerating structures. The accelerator can be extended to 1 TeV and also run as a Higgs factory at around 250 GeV and on the Z0 pole. A comprehensive value estimate of the accelerator is give, together with associated uncertainties. It is shown that no significant technical issues remain to be solved. Once a site is selected and the necessary site-dependent engineering is carried out, construction can begin immediately. The TDR also gives baseline documentation for two high-performance detectors that can share the ILC luminosity by being moved into and out of the beam line in a "push-pull" configuration. These detectors, ILD and SiD, are described in detail. They form the basis for a world-class experimental programme that promises to incr...

  15. Internal transport barrier triggered by non-linear lower hybrid wave deposition under condition of beam-driven toroidal rotation

    Energy Technology Data Exchange (ETDEWEB)

    Gao, Q. D., E-mail: qgao@swip.ac.cn [Southwestern Institute of Physics, Chengdu 610041 (China); Budny, R. V. [Princeton Plasma Physics Laboratory, Princeton University, Princeton, New Jersey 08543 (United States)

    2015-03-15

    By using gyro-Landau fluid transport model (GLF23), time-dependent integrated modeling is carried out using TRANSP to explore the dynamic process of internal transport barrier (ITB) formation in the neutral beam heating discharges. When the current profile is controlled by LHCD (lower hybrid current drive), with appropriate neutral beam injection, the nonlinear interplay between the transport determined gradients in the plasma temperature (T{sub i,e}) and toroidal velocity (V{sub ϕ}) and the E×B flow shear (including q-profile) produces transport bifurcations, generating spontaneously a stepwise growing ITB. In the discharge, the constraints imposed by the wave propagation condition causes interplay of the LH driven current distribution with the plasma configuration modification, which constitutes non-linearity in the LH wave deposition. The non-linear effects cause bifurcation in LHCD, generating two distinct quasi-stationary reversed magnetic shear configurations. The change of current profile during the transition period between the two quasi-stationary states results in increase of the E×B shearing flow arising from toroidal rotation. The turbulence transport suppression by sheared E×B flow during the ITB development is analysed, and the temporal evolution of some parameters characterized the plasma confinement is examined. Ample evidence shows that onset of the ITB development is correlated with the enhancement of E×B shearing rate caused by the bifurcation in LHCD. It is suggested that the ITB triggering is associated with the non-linear effects of the LH power deposition.

  16. High frequency normal mode statistics in a shallow water waveguide: the effect of random linear internal waves.

    Science.gov (United States)

    Raghukumar, Kaustubha; Colosi, John A

    2014-07-01

    Using transport theory and Monte Carlo numerical simulation, the statistical properties of mode propagation at a frequency of 1 kHz are studied in a shallow water environment with random sound-speed perturbations from linear internal waves. The environment is typical of summer conditions in the mid-Atlantic bight during the Shallow Water 2006 experiment. Observables of interest include the second and fourth moments of the mode amplitudes, which are relevant to full-field mean intensity and scintillation index. It is found that mode phase randomization has a strong adiabatic component while at the same time mode coupling rates are significant. As a consequence, a computationally efficient transport theory is presented, which models cross-mode correlation adiabatically, but accounts for mode coupling using the mode energy equations of Creamer [(1996). J. Acoust. Soc. Am. 99, 2825-2838]. The theory also has closed-form expressions for the internal wave scattering matrix and a correction for an edge effect. The hybrid transport theory is shown to accurately reproduce many statistical quantities from the Monte Carlo simulations.

  17. Trimer effects in fragment molecular orbital-linear combination of molecular orbitals calculation of one-electron orbitals for biomolecules.

    Science.gov (United States)

    Kobori, Tomoki; Sodeyama, Keitaro; Otsuka, Takao; Tateyama, Yoshitaka; Tsuneyuki, Shinji

    2013-09-07

    The fragment molecular orbital (FMO)-linear combination of molecular orbitals (LCMO) method incorporates as an efficient post-process calculation of one-electron orbitals of the whole system after the FMO total energy calculation. A straightforward way to increase the accuracy is inclusion of the trimer effect. Here, we derive a comprehensive formulation called the FMO3-LCMO method. To keep the computational costs of the trimer term low enough, we use a matrix-size reduction technique. We evaluated the accuracy and efficiency of the FMO3-LCMO scheme in model biological systems (alanine oligomer and chignolin). The results show that delocalized electronic orbitals with covalent and hydrogen bonds are better described at the trimer level, and the FMO3-LCMO method is applicable to quantitative evaluations of a wide range of frontier orbitals in large biosystems.

  18. Comparison of strategies for combining dynamic linear models with artificial neural networks for detecting diarrhea in slaughter pigs

    DEFF Research Database (Denmark)

    Jensen, D. B.; Kristensen, A. R.

    2016-01-01

    , can provide early and automatic detection of diarrhea. To determine the best approach to achieve this goal, we compared 36 different strategies for combining a multivariate dynamic linear model (DLM) with an artificial neural network (ANN). We used data collected in 16 pens between November 2013...... and December 2014 at a commercial Danish pig farm. The pen level water flow (liters/hour/pig) and drinking bouts frequency (bouts/hour/pig) were monitored. Staff registrations of diarrhea were the events of interest. Mean water flow and drinking bouts frequency were each modeled using three harmonic waves......) and simga-1, sigma-2, or sigma-3 cutoff thresholds. Furthermore, observations from between 0 and 48 hours before the day of the observation, with steps of 6 hours, were included in the ANN training window. Thus between 87 and 277 diarrhea-associated observations were included. The diarrhea...

  19. Combining Low Price, Low Climate Impact and High Nutritional Value in One Shopping Basket through Diet Optimization by Linear Programming

    Directory of Open Access Journals (Sweden)

    Corné van Dooren

    2015-09-01

    Full Text Available Background: This study aims to find diets with low price and low climate impact, yet fulfilling all nutritional requirements. Methods: Optimization by linear programming. The program constrains 33 nutrients to fulfill Dutch dietary requirements. In a second cycle, the upper boundary for climate impact through greenhouse gas emissions (GHGE is set to 1.6 kg carbon dioxide equivalents/day (CO2eq. In a third cycle, the costs are set on €2.50 as a constraint. The objective function of the optimization maximized the most consumed food products (n = 206 for male and female adults separately (age 31–50. Results: A diet of 63 popular and low priced basic products was found to deliver all required nutrients at an adequate level for both male and female adults. This plant-based, carbohydrate and fiber-rich diet consists mainly of wholegrain bread, potatoes, muesli, open-field vegetables and fruits. The climate impact of this diet is very low (1.59 kg CO2eq/day compared to the average Dutch diet. By constraining costs, a low carbon diet of €2.59/day is possible. Conclusions: A two-person diet consisting of 63 products and costing €37 per week can simultaneously be healthy and yet have half the average climate impact. Linear programming is a promising tool to combine health and sustainability on both societal and individual levels.

  20. Studying non-linearity of Mercury magnetosphere and solar wind interaction features using the combined hybrid model

    Science.gov (United States)

    Parunakian, David; Dyadechkin, Sergey; Alexeev, Igor; Belenkaya, Elena; Khodachenko, Maxim; Kallio, Esa; Alho, Markku

    2017-04-01

    The main focus of this work is to investigate non-linearity of Mercury's magnetospheric features. We use the paraboloid magnetospheric model (PMM) to calculate the initial magnetospheric field which we then use in hybrid simulations. We show that the initial total magnetospheric field can be considered a linear combination of the planetary dipole field, magnetospheric current system fields, and a penetrating portion of the interplanetary magnetic field (IMF). We use two sets of modelling runs with IMF values of identical magnitudes and anti-parallel directions. We then compute semi-sums and semi-differences of final magnetic field maps generated by hybrid plasma simulations, and use semi-sums to cancel out IMF contributions and semi-differences to cancel out PMM contributions. The remnant fields outside and inside the magnetosphere (for semi-sum and semi-difference fields, accordingly) are used to improve our ability to determine the position of the bow shock and magnetopause, as well as calculate the IMF penetration coefficient that results into best matches of this model to observational MESSENGER data. We compare Mercury's magnetosheath magnetic field predicted by our model with MESSENGER data in the appropriate orbit sections.

  1. Performance of an Axisymmetric Rocket Based Combined Cycle Engine During Rocket Only Operation Using Linear Regression Analysis

    Science.gov (United States)

    Smith, Timothy D.; Steffen, Christopher J., Jr.; Yungster, Shaye; Keller, Dennis J.

    1998-01-01

    The all rocket mode of operation is shown to be a critical factor in the overall performance of a rocket based combined cycle (RBCC) vehicle. An axisymmetric RBCC engine was used to determine specific impulse efficiency values based upon both full flow and gas generator configurations. Design of experiments methodology was used to construct a test matrix and multiple linear regression analysis was used to build parametric models. The main parameters investigated in this study were: rocket chamber pressure, rocket exit area ratio, injected secondary flow, mixer-ejector inlet area, mixer-ejector area ratio, and mixer-ejector length-to-inlet diameter ratio. A perfect gas computational fluid dynamics analysis, using both the Spalart-Allmaras and k-omega turbulence models, was performed with the NPARC code to obtain values of vacuum specific impulse. Results from the multiple linear regression analysis showed that for both the full flow and gas generator configurations increasing mixer-ejector area ratio and rocket area ratio increase performance, while increasing mixer-ejector inlet area ratio and mixer-ejector length-to-diameter ratio decrease performance. Increasing injected secondary flow increased performance for the gas generator analysis, but was not statistically significant for the full flow analysis. Chamber pressure was found to be not statistically significant.

  2. The association of defensin HNP-2 with negatively charged membranes: A combined fluorescence and linear dichroism study.

    Science.gov (United States)

    Pridmore, Catherine J; Rodger, Alison; Sanderson, John M

    2016-04-01

    The association of defensin HNP-2 with negatively charged membranes has been studied using a new approach that combines fluorescence and linear dichroism (LD) spectroscopies with simulated LD spectra in order to characterise the binding kinetics and bound configurations of the peptide. Binding to membranes composed of mixtures of diacylglycerophosphocholines (PC) with either diacylglycerophosphoglycerol (PG) or diacylglycerophosphoserine (PS) was conducted at lipid:peptide ratios that yielded binding, but not membrane fusion. HNP-2 association with membranes under these conditions was a 2 stage-process, with both stages exhibiting first order kinetics. The fast initial step, with a half-life of 3 min. Conversion between the states was estimated to have an enthalpy of activation of approximately 10 kJ mol(-1) and an entropy of activation of -0.2 kJ K mol(-1). LD spectra corresponding to each of the membrane bound states were generated by non-linear regression using a standard kinetic model. These spectra are interpreted in comparison with spectra calculated using the program Dichrocalc and reveal that the peptide associates with membranes in a small number of stable configurations. All of these configurations have a significant proportion of β-sheet structure residing in the plane of the membrane. Two configurations support structures previously proposed for defensins in membranes. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

  3. Linear combination fitting data

    Data.gov (United States)

    U.S. Environmental Protection Agency — The dataset shows the weighted percentage of arsenic speciation for untreated and treated soil samples with amendments designed to immobilize arsenic in soils. This...

  4. The E166 experiment: Development of an Undulator-Based Polarized Positron Source for the International Linear Collider

    Energy Technology Data Exchange (ETDEWEB)

    Kovermann, J.; Stahl, A.; /Aachen, Tech. Hochsch.; Mikhailichenko, A.A.; /Cornell U., Phys. Dept.; Scott, D.; /Daresbury; Moortgat-Pick, G.A.; /Durham U.; Gharibyan, V.; Pahl, P.; Poschl, R.; Schuler, K.P.; /DESY; Laihem, K.; Riemann, S.; Schalicke, A.; /DESY, Zeuthen; Dollan, R.; Kolanoski, H.; Lohse, T.; Schweizer, T.; /Humboldt U., Berlin; McDonald, K.T.; /Princeton U.; Batygin, Y.; Bharadwaj, V.; Bower, G.; Decker, F.J.; /SLAC /Tel Aviv U. /Tennessee U.

    2011-11-14

    A longitudinal polarized positron beam is foreseen for the international linear collider (ILC). A proof-of-principle experiment has been performed in the final focus test beam at SLAC to demonstrate the production of polarized positrons for implementation at the ILC. The E166 experiment uses a 1 m long helical undulator in a 46.6 GeV electron beam to produce a few MeV photons with a high degree of circular polarization. These photons are then converted in a thin target to generate longitudinally polarized e{sup +} and e{sup -}. The positron polarization is measured using a Compton transmission polarimeter. The data analysis has shown asymmetries in the expected vicinity of 3.4% and {approx}1% for photons and positrons respectively and the expected positron longitudinal polarization is covering a range from 50% to 90%. The full exploitation of the physics potential of an international linear collider (ILC) will require the development of polarized positron beams. Having both e{sup +} and e{sup -} beams polarized will provide new insight into structures of couplings and thus give access to physics beyond the standard model [1]. The concept for a polarized positron source is based on circularly polarized photon sources. These photons are then converted to longitudinally polarized e{sup +} and e{sup -} pairs. While in an experiment at KEK [1a], Compton backscattering is used [2], the E166 experiment uses a helical undulator to produce polarized photons. An undulator-based positron source for the ILC has been proposed in [3,4]. The proposed scheme for an ILC positron source is illustrated in figure 1. In this scheme, a 150 GeV electron beam passes through a 120 m long helical undulator to produce an intense photon beam with a high degree of circular polarization. These photons are converted in a thin target to e{sup +} e{sup -} pairs. The polarized positrons are then collected, pre-accelerated to the damping ring and injected to the main linac. The E166 experiment is

  5. Single-Tooth Osteotomy Combined Wide Linear Corticotomy Under Local Anesthesia for Correcting Anterior Protrusion With Ectopically Erupted Canine.

    Science.gov (United States)

    Iskenderoglu, Nur Serife; Choi, Byung-Joon; Seo, Kyung Won; Lee, Yeon-Ji; Lee, Baek-Soo; Kim, Seong-Hun

    2017-01-01

    This article presents the alternative surgical treatments of both anterior protrusion by carrying out retraction on mandibular anterior fragment, meanwhile applying retraction force on maxilla anterior teeth and ectopically erupted canine with using platelet-rich fibrin (PRF). Anterior segmental osteotomy was combined with linear corticotomy under local anesthesia. The correction of right ectopic canine was achieved through 2 stages. First, dento-osseous osteotomy on palatal side was performed. Then second osteotomy with immediate manual repositioning of the canine with concomitant first premolar extraction was enhanced with PRF, which was prepared by centrifuging patient's blood, applied into buccal side of high canine during osteotomy. Mandibular retraction was accomplished by anterior segmental osteotomy. Single-tooth osteotomy is a more effective surgical method for ankylosed or ectopically erupted tooth in orthodontic treatment. It can reduce the total orthodontic treatment time and root resorption, 1 common complication. Significant improved bone formation was seen with the addition of PRF on noncritical size defects in the animal model. It is reasonable to think that PRF can promote bone regeneration. So early bone formation also can reduce the complication such as postoperative infection. As an alternative to anterior protrusion and ectopically erupted canine treatment, segmental osteotomy and corticotomy combined platelet-rich plasma can enhance orthodontic treatment outcome.

  6. Study of quality assurance regulations for linear accelerators in Korea: A comparison study between the current status in Korea and the international guidelines

    CERN Document Server

    Lee, Hyunho; Jo, Yunhui; Yoon, Myonggeun

    2015-01-01

    Quality assurance (QA) for medical linear accelerators is indispensable for appropriate cancer treatment. Some international organizations and western advanced countries provide QA guidelines for linear accelerators. Currently, QA regulations for linear accelerators in Korean hospitals specify a system in which each hospital stipulates its independent hospital-based protocols for QA procedures (HP_QAPs) and conducts QA based on these HP_QAPs while regulatory authorities verify whether items under these HP_QAPs have been performed. However, because this regulatory method cannot guarantee the quality of universal treatment, and QA items with tolerance criteria are different in many hospitals, the presentation of standardized QA items and tolerance criteria is essential. In this study, QA items in HP_QAPs from various hospitals and those presented by international organizations. Concordance rates between QA items for linear accelerators that were presented by the aforementioned organizations and those currently ...

  7. Charcot foot reconstruction with combined internal and external fixation: case report

    Directory of Open Access Journals (Sweden)

    Zgonis Thomas

    2010-02-01

    Full Text Available Abstract Charcot neuroarthropathy is a destructive and often-limb threatening process that can affect patients with peripheral neuropathy of any etiology. Early recognition and appropriate management is crucial to prevention of catastrophic outcomes. Delayed diagnosis and subsequent pedal collapse often preclude successful conservative management of these deformities and necessitate surgical intervention for limb salvage. We review the current literature on surgical reconstruction of Charcot neuroarthropathy and present a case report of foot reconstruction with combined internal and external fixation methods.

  8. Combined epiretinal and internal limiting membrane peeling facilitated by high dilution indocyanine green negative staining

    Directory of Open Access Journals (Sweden)

    Mark M Kaehr

    2015-01-01

    Full Text Available We describe the utilization of indocyanine green (ICG dye to facilitate combined/en bloc removal of epiretinal membranes (ERM along with internal limiting membranes (ILM. The method utilizes a highly diluted preparation of ICG in dextrose water solvent (D5W. Elimination of fluid air exchange step facilitating staining in the fluid phase and low intensity lighting help minimize potential ICG toxicity. The technique demonstrates how ICG facilitates negative staining of ERMs and how ILM peeling concomitantly can allow complete and efficient ERM removal minimizing surgical time and the necessity for dual or sequential staining.

  9. Finite element analysis of the stability of combined plate internal fixation in posterior wall fractures of acetabulum.

    Science.gov (United States)

    Liu, Xi-Ming; Pan, Chang-Wu; Wang, Guo-Dong; Cai, Xian-Hua; Chen, Lei; Meng, Cheng-Fei; Huang, Jin-Cheng

    2015-01-01

    This study aims to explore the mechanical stability of combined plate internal fixation in posterior wall fractures of the acetabulum. The fracture and internal fixation models were established in this study and they were divided into four kinds of internal fixation models, finite element analysis was performed. The four groups were 2 mini-plates and 1 reconstruction plate fixation (A), Reconstruction plate internal fixation group (B), 2 screws internal fixation group (C) and mini-plates internal fixation group (D). The displacement of each node was measured and evaluated. There was no distortion in the geometric shape of the finite element model. The results of stress showed that it was less in the anterior pelvic ring and distributed uniform in labrum acetabulare; the stress was bigger in the upper and middle of sacroiliac joint and sciatic notch in sitting position. Combined plate internal fixation for posterior wall fractures of acetabular were stable and reliable, it is better than the other three methods.

  10. Implications of the 750 GeV gamma-gamma Resonance as a Case Study for the International Linear Collider

    CERN Document Server

    Fujii, Keisuke; Peskin, Michael E; Barklow, Tim; Gao, Yuanning; Kanemura, Shinya; Kim, Hyungdo; List, Jenny; Nojiri, Mihoko; Perelstein, Maxim; Poeschl, Roman; Reuter, Juergen; Simon, Frank; Tanabe, Tomohiko; Yu, Jaehoon; Wells, James D; Falkowski, Adam; Matsumoto, Shigeki; Moroi, Takeo; Richard, Francois; Tian, Junping; Vos, Marcel; Yokoya, Hiroshi; Murayama, Hitoshi; Yamamoto, Hitoshi

    2016-01-01

    If the gamma-gamma resonance at 750 GeV suggested by 2015 LHC data turns out to be a real effect, what are the implications for the physics case and upgrade path of the International Linear Collider? Whether or not the resonance is confirmed, this question provides an interesting case study testing the robustness of the ILC physics case. In this note, we address this question with two points: (1) Almost all models proposed for the new 750 GeV particle require additional new particles with electroweak couplings. The key elements of the 500 GeV ILC physics program---precision measurements of the Higgs boson, the top quark, and 4-fermion interactions---will powerfully discriminate among these models. This information will be important in conjunction with new LHC data, or alone, if the new particles accompanying the 750 GeV resonance are beyond the mass reach of the LHC. (2) Over a longer term, the energy upgrade of the ILC to 1 TeV already discussed in the ILC TDR will enable experiments in gamma-gamma and e+e- ...

  11. Implications of the 750 GeV γγ Resonance as a Case Study for the International Linear Collider

    Energy Technology Data Exchange (ETDEWEB)

    Fujii, Keisuke [High Energy Accelerator Research Organization (KEK), Tsukuba (Japan); Grojean, Christophe [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Univ. Autonoma de Barcelona (Spain). Inst. Catalana de Recerca i Estudis Avancats (ICREA) and Inst. de Fisica d' Altes Energies (IFAE); Peskin, Michael E. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Barklow, Tim [SLAC National Accelerator Lab., Menlo Park, CA (United States); Gao, Yuanning [Tsinghua Univ., Beijing (China). Center for High Energy Physics; Kanemura, Shinya [Univ. of Toyama (Japan). Dept. of Physics; Kim, Hyungdo [Seoul National Univ. (Korea, Republic of). Dept. of Physics and Astronomy; List, Jenny [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Nojiri, Mihoko [High Energy Accelerator Research Organization (KEK), Tsukuba (Japan); Univ. of Tokyo (Japan). Kavli Inst. for the Physics and Mathematics of the Universe; Perelstein, Maxim [Cornell Univ., Ithaca, NY (United States). Lab. for Elementary Particle Physics; Poschl, Roman [Univ. Paris-Sud, Orsay (France). Linear Accelerator Lab. (LAL). Centre Scientifique d' Orsay; Reuter, Jurgen [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Simon, Frank [Max Planck Inst. for Physics (MPP), Munich (Germany); Tanabe, Tomohiko [Univ. of Tokyo (Japan). International Center for Elementary Particle Physics (ICEPP); Yu, Jaehoon [Univ. of Texas, Arlington, TX (United States). Dept. of Physics; Wells, James D. [Univ. of Michigan, Ann Arbor, MI (United States). Michigan Center for Theoretical Physics; Falkowski, Adam [Univ. Paris-Sud, Orsay (France). Lab. of Theoretical Physics (LPT); Matsumoto, Shigeki [Univ. of Tokyo (Japan). Kavli Inst. for the Physics and Mathematics of the Universe; Moroi, Takeo [Univ. of Tokyo (Japan). Dept. of Physics; Richard, Francois [Univ. Paris-Sud, Orsay (France). Linear Accelerator Lab. (LAL). Centre Scientifique d' Orsay; Tian, Junping [Univ. of Tokyo (Japan). International Center for Elementary Particle Physics (ICEPP); Vos, Marcel [Spanish National Research Council (CSIC), Valencia (Spain) and Univ. of Valencia (Spain). Inst. for Corpuscular Physics (IFIC); Yokoya, Hiroshi [Korean Inst. for Advanced Study (KIAS), Seoul (Korea, Republic of ). Quantum Universe Center; Murayama, Hitoshi [Univ. of Tokyo (Japan). Kavli Inst. for the Physics and Mathematics of the Universe; Univ. of California, Berkeley, CA (United States). Dept. of Physics; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Yamamoto, Hitoshi [Tohoku Univ., Sendai (Japan). Dept. of Physics

    2016-07-14

    If the γγ resonance at 750 GeV suggested by 2015 LHC data turns out to be a real effect, what are the implications for the physics case and upgrade path of the International Linear Collider? Whether or not the resonance is confirmed, this question provides an interesting case study testing the robustness of the ILC physics case. In this note, we address this question with two points: (1) Almost all models proposed for the new 750 GeV particle require additional new particles with electroweak couplings. The key elements of the 500 GeV ILC physics program - precision measurements of the Higgs boson, the top quark, and 4-fermion interactions - will powerfully discriminate among these models. This information will be important in conjunction with new LHC data, or alone, if the new particles accompanying the 750 GeV resonance are beyond the mass reach of the LHC. (2) Over a longer term, the energy upgrade of the ILC to 1 TeV already discussed in the ILC TDR will enable experiments in γγ and e+e- collisions to directly produce and study the 750 GeV particle from these unique initial states.

  12. Streamwise-body-force-model for rapid simulation combining internal and external flow fields

    Directory of Open Access Journals (Sweden)

    Cui Rong

    2016-10-01

    Full Text Available A streamwise-body-force-model (SBFM is developed and applied in the overall flow simulation for the distributed propulsion system, combining internal and external flow fields. In view of axial stage effects, fan or compressor effects could be simplified as body forces along the streamline. These body forces which are functions of local parameters could be added as source terms in Navier-Stokes equations to replace solid boundary conditions of blades and hubs. The validation of SBFM with uniform inlet and distortion inlet of compressors shows that pressure performance characteristics agree well with experimental data. A three-dimensional simulation of the integration configuration, via a blended wing body aircraft with a distributed propulsion system using the SBFM, has been completed. Lift coefficient and drag coefficient agree well with wind tunnel test results. Results show that to reach the goal of rapid integrated simulation combining internal and external flow fields, the computational fluid dynamics method based on SBFM is reasonable.

  13. Genetic parameters for social effects on survival in cannibalistic layers: Combining survival analysis and a linear animal model

    Directory of Open Access Journals (Sweden)

    Veerkamp Roel F

    2010-07-01

    Full Text Available Abstract Background Mortality due to cannibalism in laying hens is a difficult trait to improve genetically, because censoring is high (animals still alive at the end of the testing period and it may depend on both the individual itself and the behaviour of its group members, so-called associative effects (social interactions. To analyse survival data, survival analysis can be used. However, it is not possible to include associative effects in the current software for survival analysis. A solution could be to combine survival analysis and a linear animal model including associative effects. This paper presents a two-step approach (2STEP, combining survival analysis and a linear animal model including associative effects (LAM. Methods Data of three purebred White Leghorn layer lines from Institut de Sélection Animale B.V., a Hendrix Genetics company, were used in this study. For the statistical analysis, survival data on 16,780 hens kept in four-bird cages with intact beaks were used. Genetic parameters for direct and associative effects on survival time were estimated using 2STEP. Cross validation was used to compare 2STEP with LAM. LAM was applied directly to estimate genetic parameters for social effects on observed survival days. Results Using 2STEP, total heritable variance, including both direct and associative genetic effects, expressed as the proportion of phenotypic variance, ranged from 32% to 64%. These results were substantially larger than when using LAM. However, cross validation showed that 2STEP gave approximately the same survival curves and rank correlations as LAM. Furthermore, cross validation showed that selection based on both direct and associative genetic effects, using either 2STEP or LAM, gave the best prediction of survival time. Conclusion It can be concluded that 2STEP can be used to estimate genetic parameters for direct and associative effects on survival time in laying hens. Using 2STEP increased the heritable

  14. Four-Wave Mixing Crosstalk Suppression Based on the Pairing Combinations of Differently Linear-Polarized Optical Signals

    Directory of Open Access Journals (Sweden)

    Haider Abd

    2014-01-01

    Full Text Available A new approach to suppressing the four-wave mixing (FWM crosstalk by using the pairing combinations of differently linear-polarized optical signals was investigated. The simulation was conducted using a four-channel system, and the total data rate was 40 Gb/s. A comparative study on the suppression of FWM for existing and suggested techniques was conducted by varying the input power from 2 dBm to 14 dBm. The robustness of the proposed technique was examined with two types of optical fiber, namely, single-mode fiber (SMF and dispersion-shifted fiber (DSF. The FWM power drastically reduced to less than −68 and −25 dBm at an input power of 14 dBm, when the polarization technique was conducted for SMF and DSF, respectively. With the conventional method, the FWM powers were, respectively, −56 and −20 dBm. The system performance greatly improved with the proposed polarization approach, where the bit error rates (BERs at the first channel were 2.57×10-40 and 3.47×10-29 at received powers of −4.90 and −13.84 dBm for SMF and DSF, respectively.

  15. Siting MSW landfill using weighted linear combination and analytical hierarchy process (AHP) methodology in GIS environment (case study: Karaj).

    Science.gov (United States)

    Moeinaddini, Mazaher; Khorasani, Nematollah; Danehkar, Afshin; Darvishsefat, Ali Asghar; Zienalyan, Mehdi

    2010-05-01

    Selection of landfill site is a complex process and needs many diverse criteria. The purpose of this paper is to evaluate the suitability of the studied site as landfill for MSW in Karaj. Using weighted linear combination (WLC) method and spatial cluster analysis (SCA), suitable sites for allocation of landfill for a 20-year period were identified. For analyzing spatial auto-correlation of the land suitability map layer (LSML), Maron's I was used. Finally, using the analytical hierarchy process (AHP), the most preferred alternative for the landfill siting was identified. Main advantages of AHP are: relative ease of handling multiple criteria, easy to understand and effective handling of both qualitative and quantitative data. As a result, 6% of the study area is suitable for landfill siting and third alternative was identified as the most preferred for siting MSW landfill by AHP. The ranking of alternatives were obtained only by applying the WLC approach showed different results from the AHP. The WLC should be used only for the identification of alternatives and the AHP is used for prioritization. We suggest the employed procedure for other similar regions.

  16. Spectral analysis combined with advanced linear unmixing allows for histolocalization of phenolics in leaves of coffee trees

    Directory of Open Access Journals (Sweden)

    Geneviève eConéjéro

    2014-02-01

    Full Text Available An imaging method using spectral analysis combined with advanced linear unmixing was used to allow histolocalization of natural autofluorescent compounds such as hydroxycinnamic acid (chlorogenic acid and xanthone (mangiferin in living cells and tissues (mature coffee leaves. The tested method included three complementary steps: 1/ visualization of natural autofluorescence and spectrum acquisition with a multiphoton microscope; 2/ identification of some compounds using previous information on the chemical composition of the tissue, obtained from litterature; and 3/ localization of candidate compounds by spectral imaging. The second part of the study consisted of describing the histochemical structure of leaves during their development. This revealed very fast histochemical differentiation of leaves during the first week after their emergence. Lastly, young leaves of Coffea pseudozanguebariae (PSE, C. eugenioides (EUG, C. arabica (ARA and C. canephora (CAN were compared. This confirmed the presence of xanthone in PSE and EUG, but especially its precise tissue localization. This also highlighted the paternal CAN origin of the leaf structure in the allotetraploid species ARA. The limits and advantages of the method without staining are discussed relative to classical epifluorescence microscopy under UV light. This non-invasive optical technique does not require pretreatment and is an effective experimental tool to differentiate multiple naturally-occuring fluorochores in living tissues.

  17. Combining experimental techniques with non-linear numerical models to assess the sorption of pesticides on soils

    Science.gov (United States)

    Magga, Zoi; Tzovolou, Dimitra N.; Theodoropoulou, Maria A.; Tsakiroglou, Christos D.

    2012-03-01

    The risk assessment of groundwater pollution by pesticides may be based on pesticide sorption and biodegradation kinetic parameters estimated with inverse modeling of datasets from either batch or continuous flow soil column experiments. In the present work, a chemical non-equilibrium and non-linear 2-site sorption model is incorporated into solute transport models to invert the datasets of batch and soil column experiments, and estimate the kinetic sorption parameters for two pesticides: N-phosphonomethyl glycine (glyphosate) and 2,4-dichlorophenoxy-acetic acid (2,4-D). When coupling the 2-site sorption model with the 2-region transport model, except of the kinetic sorption parameters, the soil column datasets enable us to estimate the mass-transfer coefficients associated with solute diffusion between mobile and immobile regions. In order to improve the reliability of models and kinetic parameter values, a stepwise strategy that combines batch and continuous flow tests with adequate true-to-the mechanism analytical of numerical models, and decouples the kinetics of purely reactive steps of sorption from physical mass-transfer processes is required.

  18. International Frameworks Dealing with Human Risk Assessment of Combined Exposure to Multiple Chemicals

    Directory of Open Access Journals (Sweden)

    European Food Safety Authority

    2013-07-01

    Full Text Available The development of harmonised terminology and frameworks for the human risk assessment of combined exposure to multiple chemicals (“chemical mixtures” is an important area for EFSA and a number of activities have already been undertaken, i.e. in the fields of pesticides and contaminants. The first step prior to a risk assessment of combined exposure to multiple chemicals is problem formulation defining the relevant exposure, hazard and population to be considered. In practice, risk assessment of multiple chemicals is conducted using a tiered approach for exposure assessment, hazard assessment and risk characterisation. Higher tiers require increasing knowledge about the group of chemicals under assessment and the tiers can range from tier 0 (default values, data poor situation to tier 3 (full probabilistic models. This scientific report reviews the terminology, methodologies and frameworks developed by national and international agencies for the human risk assessment of combined exposure to multiple chemicals and provides recommendations for future activities at EFSA in this area.

  19. PREFACE: Second International Conference on Photo-Induced Phase Transitions; Cooperative, non-linear and functional properties (PIPT'05)

    Science.gov (United States)

    Buron, Marylise; Collet, Eric

    2005-01-01

    This issue is a collection of papers presented at the 2nd International Conference on Photo-Induced Phase Transitions; Cooperative, non-linear and functional properties (PIPT'05), which was held in Rennes (France) on 24-28 May 2005 and chaired by Hervé Cailleau and Tadeusz Luty. The first PIPT conference was organized by Professor Keiichiro Nasu in Tsukuba, Japan, in 2001. During 5 days, PIPT'05 provided an interdisciplinary forum for research communications between solid state physicists, photophysicists, photochemists and photobiologists, as well as material scientists. Scientists came from all around the world (Europe, Japan, USA, Canada, ...). The fascinating scientific challenge of the possibility of triggering physical properties of a material by light excitation was at the heart of the exchange of ideas between scientists of the different fields. The topics of the conference were about light-induced phenomena in functional materials, nano-particles and devices, photo-induced structural, magnetic and/or electronic phase transitions, photo-induced gauge type phase transitions, photo-induced cooperative molecular switching and chemical reactions in solids, dynamics of out-of-equilibrium processes, light-driven non-thermal processes such as coherent phonons, shock waves, surface melting and femtomagnetism, precursor phenomena, coherent, co-operative and non-linear processes in excited states and new investigations by light, x-ray and electron probes. As you will see, the collection of papers presented here cover many of the fields mentioned above. The PIPT conferences, encompassing different areas of light-induced phenomena are also meant to bridge the gap between experimentalists and theoreticians, and to promote communication between scientists working on different continents. The present conference was attended by 148 participants from 17 countries, with the total number of 87 presentations (16 invited, 27 contributed talks and 44 posters). It is encouraging

  20. Combined influences of genes, prenatal environment, cortisol, and parenting on the development of children’s internalizing vs. externalizing problems

    OpenAIRE

    MARCEAU, KRISTINE; Laurent, Heidemarie K.; Neiderhiser, Jenae M.; Reiss, David; Daniel S Shaw; Natsuaki, Misaki; Fisher, Philip A.; Leve, Leslie D.

    2014-01-01

    Research suggests that genetic, prenatal, endocrine, and parenting influences across development individually contribute to internalizing and externalizing problems in children. The present study tests the combined contributions of genetic risk for psychopathology, prenatal environments (maternal drug use and internalizing symptoms), child cortisol at age 4.5 years, and overreactive parenting influences across childhood on 6-year-old children’s internalizing and externalizin...

  1. A combined linear optimisation methodology for water resources allocation in Alfeios River Basin (Greece) under uncertain and vague system conditions

    Science.gov (United States)

    Bekri, Eleni; Yannopoulos, Panayotis; Disse, Markus

    2013-04-01

    In the present study, a combined linear programming methodology, based on Li et al. (2010) and Bekri et al. (2012), is employed for optimizing water allocation under uncertain system conditions in the Alfeios River Basin, in Greece. The Alfeios River is a water resources system of great natural, ecological, social and economic importance for Western Greece, since it has the longest and highest flow rate watercourse in the Peloponnisos region. Moreover, the river basin was exposed in the last decades to a plethora of environmental stresses (e.g. hydrogeological alterations, intensively irrigated agriculture, surface and groundwater overexploitation and infrastructure developments), resulting in the degradation of its quantitative and qualitative characteristics. As in most Mediterranean countries, water resource management in Alfeios River Basin has been focused up to now on an essentially supply-driven approach. It is still characterized by a lack of effective operational strategies. Authority responsibility relationships are fragmented, and law enforcement and policy implementation are weak. The present regulated water allocation puzzle entails a mixture of hydropower generation, irrigation, drinking water supply and recreational activities. Under these conditions its water resources management is characterised by high uncertainty and by vague and imprecise data. The considered methodology has been developed in order to deal with uncertainties expressed as either probability distributions, or/and fuzzy boundary intervals, derived by associated α-cut levels. In this framework a set of deterministic submodels is studied through linear programming. The ad hoc water resources management and alternative management patterns in an Alfeios subbasin are analyzed and evaluated under various scenarios, using the above mentioned methodology, aiming to promote a sustainable and equitable water management. Li, Y.P., Huang, G.H. and S.L., Nie, (2010), Planning water resources

  2. Deconvolution of a linear combination of Gaussian kernels by an inhomogeneous Fredholm integral equation of second kind and applications to image processing

    CERN Document Server

    Ulmer, Waldemar

    2011-01-01

    Scatter processes of photons lead to blurring of images. Multiple scatter can usually be described by one Gaussian convolution kernel. This can be a crude approximation and we need a linear combination of 2/3 Gaussian kernels to account for tails.If image structures are recorded by appropriate measurements, these structures are always blurred. The ideal image (source function without any blurring) is subjected to Gaussian convolutions to yield a blurred image, which is recorded by a detector array. The inverse problem of this procedure is the determination of the ideal source image from really determined image. If the scatter parameters are known, we are able to calculate the idealistic source structure by a deconvolution. We shall extend it to linear combinations of two/three Gaussian convolution kernels in order to found applications to aforementioned image processing, where a single Gaussian kernel would be crude. In this communication, we shall derive a new deconvolution method for a linear combination of...

  3. Combined exposures: an update from the International Commission on Biological Effects of Noise.

    Science.gov (United States)

    Leroux, Tony; Klaeboe, Ronny

    2012-01-01

    International Commission on Biological Effects of Noise (ICBEN) Team 8 deals with the effects of combined "agents" in the urban and work place settings. Results presented at the ICBEN conference indicate that some pesticides, more specifically the organophosphates, and a wider range of industrial chemicals are harmful to the auditory system at concentrations often found in occupational settings. Effects of occupational noise on hearing are exacerbated by toluene and possibly by carbon monoxide. Several of the chemicals studied found to be potentially toxic not only to hair cells in the cochlea but also to the auditory nerve. In urban environments, team 8 focuses on additive and synergetic effects of ambient stressors. It was argued that noise policies need to pay attention to grey areas with intermediate noise levels. Noteworthy is also stronger reactions to vibrations experienced in the evening and during the night. An innovative event-based model for sound perception was presented.

  4. On the Teaching of Linear Algebra for International Students%留学生线性代数课程的教学探索

    Institute of Scientific and Technical Information of China (English)

    何洪津

    2016-01-01

    This paper first studies the background of linear algebra for international students. Then,we summarize some problems and reflections that we encountered in the teaching of linear algebra for international students. Finally, we list several useful suggestions for the purpose of improving the efficiency and quality of such a teaching for international students.%探讨了留学生线性代数课程开设的背景,对留学生线性代数课程的教学进行了总结和反思,对提升留学生线性代数课程教学效率和质量提出了几点建议。

  5. On-chip power-combining techniques for watt-level linear power amplifiers in 0.18 μm CMOS

    Science.gov (United States)

    Zhixiong, Ren; Kefeng, Zhang; Lanqi, Liu; Cong, Li; Xiaofei, Chen; Dongsheng, Liu; Zhenglin, Liu; Xuecheng, Zou

    2015-09-01

    Three linear CMOS power amplifiers (PAs) with high output power (more than watt-level output power) for high data-rate mobile applications are introduced. To realize watt-level output power, there are two 2.4 GHz PAs using an on-chip parallel combining transformer (PCT) and one 1.95 GHz PA using an on-chip series combining transformer (SCT) to combine output signals of multiple power stages. Furthermore, some linearization techniques including adaptive bias, diode linearizer, multi-gated transistors (MGTR) and the second harmonic control are applied in these PAs. Using the proposed power combiner, these three PAs are designed and fabricated in TSMC 0.18 μm RFCMOS process. According to the measurement results, the proposed two linear 2.4 GHz PAs achieve a gain of 33.2 dB and 34.3 dB, a maximum output power of 30.7 dBm and 29.4 dBm, with 29% and 31.3% of peak PAE, respectively. According to the simulation results, the presented linear 1.95 GHz PA achieves a gain of 37.5 dB, a maximum output power of 34.3 dBm with 36.3% of peak PAE. Project supported by the National Natural Science Foundation of China (No. 61076030).

  6. BD S三频观测值线性组合分析%Analysing The Linear Combination of the BDS Triple Frequency Observation

    Institute of Scientific and Technical Information of China (English)

    凌云; 侍荣; 丁锁妹

    2015-01-01

    Briefly introduces the theoretical basis of the linear combination of the observation in GNSS data processing .Based on the BDS triple frequency observation ,it makes a deep analysis in the characteristics of the different linear combinations of the BDS observations .And it provide the reference for BDS data processing .%简单介绍了GNSS数据处理中观测值线性组合的理论基础。基于BDS三频观测值,深入分析不同BDS观测值线性组合所具备的特点,为BDS数据处理提供参考。

  7. Internal structure of the San Jacinto fault zone at Blackburn Saddle from seismic data of a linear array

    Science.gov (United States)

    Share, Pieter-Ewald; Ben-Zion, Yehuda; Ross, Zachary E.; Qiu, Hongrui; Vernon, Frank L.

    2017-08-01

    Local and teleseismic earthquake waveforms recorded by a 180-m-long linear array (BB) with seven seismometers crossing the Clark fault of the San Jacinto fault zone northwest of Anza are used to image a deep bimaterial interface and core damage structure of the fault. Delay times of P waves across the array indicate an increase in slowness from the southwest most (BB01) to the northeast most (BB07) station. Automatic algorithms combined with visual inspection and additional analyses are used to identify local events generating fault zone head and trapped waves. The observed fault zone head waves imply that the Clark fault in the area is a sharp bimaterial interface, with lower seismic velocity on the southwest side. The moveout between the head and direct P arrivals for events within ˜40 km epicentral distance indicates an average velocity contrast across the fault over that section and the top 20 km of 3.2 per cent. A constant moveout for events beyond ˜40 km to the southeast is due to off-fault locations of these events or because the imaged deep bimaterial interface is discontinuous or ends at that distance. The lack of head waves from events beyond ˜20 km to the northwest is associated with structural complexity near the Hemet stepover. Events located in a broad region generate fault zone trapped waves at stations BB04-BB07. Waveform inversions indicate that the most likely parameters of the trapping structure are width of ˜200 m, S velocity reduction of 30-40 per cent with respect to the bounding blocks, Q value of 10-20 and depth of ˜3.5 km. The trapping structure and zone with largest slowness are on the northeast side of the fault. The observed sense of velocity contrast and asymmetric damage across the fault suggest preferred rupture direction of earthquakes to the northwest. This inference is consistent with results of other geological and seismological studies.

  8. Business combinations under common control in International Financial Reporting Standards – is authoritative accounting guidance needed?

    Directory of Open Access Journals (Sweden)

    Magdalena Janowicz

    2017-09-01

    Full Text Available Business combinations under common control in International Financial Reporting Standards – is authoritative accounting guidance needed? The purpose of the article is to answer the question if a separate standard (IFRS is needed for business combinations under common control (BCUCC, which are not governed by any IFRS as the moment. In such cases, the approach resulting from IAS 8 should apply to them, which allows the use of national regulations to account for BCUCC. The authoress shortly described the theoretical issues related to the subject and presented the results of empirical research that verified the practical aspects of the problem. The research methodology involves a literature and legal act analysis, content analysis of financial statements, as well as deductive and inductive reasoning. On the basis of the gathered data the authoress concluded that even the existence of necessary regulations in national GAAPs does not guarantee that all the requirements related to the qualitative characteristics of the reported information are met and, as such, the main objectives for which IFRS were developed may not be met. As such, the authoritative guidance proves necessary. Very little research on the subject was published, thus, this paper may provide some additional guidance as to what issues related to BCUCC should receive particular attention.

  9. In-Training Practice Patterns of Combined Emergency Medicine/Internal Medicine Residents, 2003-2007

    Directory of Open Access Journals (Sweden)

    Todd A Templeman

    2011-05-01

    Full Text Available Introduction: This study seeks to evaluate the practice patterns of current combined emergency medicine/internal medicine (EM/IM residents during their training and compare them to the typical practice patterns of EM/IM graduates. We further seek to characterize how these current residents perceive the EM/IM physician’s niche. Methods: This is a multi-institution, cross-sectional, survey-based cohort study. Between June 2008 and July 2008, all 112 residents of the 11 EM/IM programs listed by the Accreditation Council for Graduate Medical Education were contacted and asked to complete a survey concerning plans for certification, fellowship, and practice setting. Results: The adjusted response rate was 71%. All respondents anticipated certifying in both specialties, with 47% intending to pursue fellowships. Most residents (97% allotted time to both EM and IM, with a median time of 70% and 30%, respectively. Concerning academic medicine, 81% indicated intent to practice academic medicine, and 96% planned to allocate at least 10% of their future time to a university/academic setting. In evaluating satisfaction, 94% were (1 satisfied with their residency choice, (2 believed that a combined residency will advance their career, and (3 would repeat a combined residency if given the opportunity. Conclusion: Current EM/IM residents were very content with their training and the overwhelming majority of residents plan to devote time to the practice of academic medicine. Relative to the practice patterns previously observed in EM/IM graduates, the current residents are more inclined toward pursuing fellowships and practicing both specialties. [West J Emerg Med. 2011;12(4:530–536.

  10. A linear combination of pharmacophore hypotheses as a new tool in search of new active compounds--an application for 5-HT1A receptor ligands.

    Directory of Open Access Journals (Sweden)

    Dawid Warszycki

    Full Text Available This study explores a new approach to pharmacophore screening involving the use of an optimized linear combination of models instead of a single hypothesis. The implementation and evaluation of the developed methodology are performed for a complete known chemical space of 5-HT1AR ligands (3616 active compounds with K i < 100 nM acquired from the ChEMBL database. Clusters generated from three different methods were the basis for the individual pharmacophore hypotheses, which were assembled into optimal combinations to maximize the different coefficients, namely, MCC, accuracy and recall, to measure the screening performance. Various factors that influence filtering efficiency, including clustering methods, the composition of test sets (random, the most diverse and cluster population-dependent and hit mode (the compound must fit at least one or two models from a final combination were investigated. This method outmatched both single hypothesis and random linear combination approaches.

  11. Combined Influences of Genes, Prenatal Environment, Cortisol, and Parenting on the Development of Children's Internalizing Versus Externalizing Problems.

    Science.gov (United States)

    Marceau, Kristine; Laurent, Heidemarie K; Neiderhiser, Jenae M; Reiss, David; Shaw, Daniel S; Natsuaki, Misaki N; Fisher, Philip A; Leve, Leslie D

    2015-05-01

    Research suggests that genetic, prenatal, endocrine, and parenting influences across development individually contribute to internalizing and externalizing problems in children. The present study tests the combined contributions of genetic risk for psychopathology, prenatal environments (maternal drug use and internalizing symptoms), child cortisol at age 4.5 years, and overreactive parenting influences across childhood on 6-year-old children's internalizing and externalizing problems. We used data from an adoption design that included 361 domestically adopted children and their biological and adopted parents prospectively followed from birth. Only parenting influences contributed (independently) to externalizing problems. However, genetic influences were indirectly associated with internalizing problems (through increased prenatal risk and subsequent morning cortisol), and parenting factors were both directly and indirectly associated with internalizing problems (through morning cortisol). Results suggest that prenatal maternal drug use/symptoms and children's morning cortisol levels are mechanisms of genetic and environmental influences on internalizing problems, but not externalizing problems, in childhood.

  12. Combined Internal and External Fixation for Diabetic Charcot Reconstruction: A Retrospective Case Series.

    Science.gov (United States)

    Hegewald, Kenneth W; Wilder, Megan L; Chappell, Todd M; Hutchinson, Byron L

    2016-01-01

    Diabetic Charcot neuroarthropathy is a complex, limb-threatening disease process with major lifestyle-altering repercussions for patients. When Charcot neuroarthropathy leads to unstable deformity, ulceration, and potential infection despite conservative therapies, foot and ankle surgeons often consider reconstructive limb salvage procedures to restore function. The purpose of the present study was to evaluate the clinical and radiographic outcomes of diabetic Charcot reconstruction using combined internal and external fixation. A total of 22 patients were reviewed; 16 (72.73%) midfoot and 6 (27.27%) tibiotalocalcaneal arthrodesis procedures were consecutively performed from March 2009 to May 2013. All surgical procedures were performed in nonacute phases of the Charcot process in patients with diagnosed diabetes mellitus and documented peripheral neuropathy. Patients were excluded from the study if they were not diabetic despite having undergone Charcot reconstruction, regardless of the fixation method, or if they did not complete radiographic imaging. During a mean follow-up period of 58.60 ± 42.37 (range 16 to 164) weeks, limb salvage was achieved in 20 patients (90.91%), and 2 (9.09%) required below-the-knee amputation at a mean of 42 ± 14.14 weeks. Wound dehiscence occurred in 8 (36.36%), pin tract infection in 10 (45.45%), and superficial wound infection in 9 (40.91%) and peaked in bimodal fashion at 4 and 8 weeks postoperatively. Radiographic analysis of the pre- versus postoperative alignment showed statistically significant changes in the lateral talo-first metatarsal angle (p = .02) and lateral talar declination angle (p = .01). The limb salvage rates with diabetic Charcot reconstruction are improving in part because of the continued development of increasingly superior modalities for both internal and external fixation.

  13. Power and Sample Size Calculations for Testing Linear Combinations of Group Means under Variance Heterogeneity with Applications to Meta and Moderation Analyses

    Science.gov (United States)

    Shieh, Gwowen; Jan, Show-Li

    2015-01-01

    The general formulation of a linear combination of population means permits a wide range of research questions to be tested within the context of ANOVA. However, it has been stressed in many research areas that the homogeneous variances assumption is frequently violated. To accommodate the heterogeneity of variance structure, the…

  14. Combining interactive multiple goal linear programming with an inter-stakeholder communication matrix to generate land use options

    NARCIS (Netherlands)

    Nidumolu, Uday Bhaskar; Keulen, Herman van; Lubbers, Marcel; Mapfumo, Andrew

    2007-01-01

    An Interactive Multiple Goal Linear Programming (IMGLP) model is developed that considers objectives of multiple stakeholders, i.e. different farmer groups, district agricultural officers and agricultural scientists for agricultural land use analysis. The analysis focuses on crop selection;

  15. Combining interactive multiple goal linear programming with an inter-stakeholder communication matrix to generate land use options

    NARCIS (Netherlands)

    Nidumolu, Uday Bhaskar; Keulen, Herman van; Lubbers, Marcel; Mapfumo, Andrew

    2007-01-01

    An Interactive Multiple Goal Linear Programming (IMGLP) model is developed that considers objectives of multiple stakeholders, i.e. different farmer groups, district agricultural officers and agricultural scientists for agricultural land use analysis. The analysis focuses on crop selection; consider

  16. Well-posedness and exponential stability for a linear damped Timoshenko system with second sound and internal distributed delay

    Directory of Open Access Journals (Sweden)

    Tijani A. Apalara

    2014-12-01

    Full Text Available In this article we consider one-dimensional linear thermoelastic system of Timoshenko type with linear frictional damping and a distributed delay acting on the displacement equation. The heat flux of the system is governed by Cattaneo's law. Under suitable assumption on the weight of the delay and that of frictional damping, we establish the well-posedness result and prove that the system is exponentially stable regardless of the speeds of wave propagation.

  17. [Identification of adulterants in adulterated milks by near infrared spectroscopy combined with non-linear pattern recognition methods].

    Science.gov (United States)

    Ni, Li-Jun; Zhong, Lin; Zhang, Xin; Zhang, Li-Guo; Huang, Shi-Xinz

    2014-10-01

    correlative analysis between the discrimination accuracy rate and the content levels of the adulterants indicated that near infrared spectroscopy combined with non-linear pattern recognition methods can distinguish dextrin and starch in milks with higher concentration levels (> 0.15%), but do not work well on identifying the adulterants with lower concentrations such as melamine (365.5 to 1,096.5 mg kg(-1)), urea (524 to 1,572 mg · kg(-1)), ammonium nitrate (700 to 2,100 mg · kg(-1)). Therefore near Infrared Spectroscopy is not suitable for identifying the adulterants with concentrations are below 0.1%.

  18. Cp Violating Effects In W And Z Boson Pair Production At The International Linear Collider In The Minimal Supersymmetric Standard Model

    CERN Document Server

    Pahel, D J

    2005-01-01

    In the standard electroweak model, the sole source of CP violation is a CP violating phase of the CKM quark mixing matrix. The minimal supersymmetric extension of the standard model offers a large number of possible new sources of CP violation; these include both flavor dependent and flavor independent sources. These CP violating effects are studied in gauge boson production and decay processes with intermediate W and Z boson exchange. The prospects of measuring these effects in the International Linear Collider are explored.

  19. An Empiric Linear Formula between the Internal Tetrahedron Symmetric Stretch Frequency and the Al Content in the Framework of KL Molecular Sieves

    Institute of Scientific and Technical Information of China (English)

    Nong Yue HE; Chun YANG; Jian Xin TANG; Peng Feng XIAO; Hong CHEN

    2003-01-01

    KL molecular sieves with different framework compositions were secondarily synthesized by substituting Si for Al with a solution of (NH4)2SiF6. The internal tetrahedron symmetric stretch frequency, at ν770 cm-1, is linear with the molar fraction of Al (XAl= Al/(Si+Al)) in the framework of KL samples: XAl = -7.309×10-3 (υ770-760) + 0.3242.

  20. A Platform for Combined DNA and Protein Microarrays Based on Total Internal Reflection Fluorescence

    Directory of Open Access Journals (Sweden)

    Alexander Asanov

    2012-02-01

    Full Text Available We have developed a novel microarray technology based on total internal reflection fluorescence (TIRF in combination with DNA and protein bioassays immobilized at the TIRF surface. Unlike conventional microarrays that exhibit reduced signal-to-background ratio, require several stages of incubation, rinsing and stringency control, and measure only end-point results, our TIRF microarray technology provides several orders of magnitude better signal-to-background ratio, performs analysis rapidly in one step, and measures the entire course of association and dissociation kinetics between target DNA and protein molecules and the bioassays. In many practical cases detection of only DNA or protein markers alone does not provide the necessary accuracy for diagnosing a disease or detecting a pathogen. Here we describe TIRF microarrays that detect DNA and protein markers simultaneously, which reduces the probabilities of false responses. Supersensitive and multiplexed TIRF DNA and protein microarray technology may provide a platform for accurate diagnosis or enhanced research studies. Our TIRF microarray system can be mounted on upright or inverted microscopes or interfaced directly with CCD cameras equipped with a single objective, facilitating the development of portable devices. As proof-of-concept we applied TIRF microarrays for detecting molecular markers from Bacillus anthracis, the pathogen responsible for anthrax.

  1. A generating set direct search augmented Lagrangian algorithm for optimization with a combination of general and linear constraints.

    Energy Technology Data Exchange (ETDEWEB)

    Lewis, Robert Michael (College of William and Mary, Williamsburg, VA); Torczon, Virginia Joanne (College of William and Mary, Williamsburg, VA); Kolda, Tamara Gibson

    2006-08-01

    We consider the solution of nonlinear programs in the case where derivatives of the objective function and nonlinear constraints are unavailable. To solve such problems, we propose an adaptation of a method due to Conn, Gould, Sartenaer, and Toint that proceeds by approximately minimizing a succession of linearly constrained augmented Lagrangians. Our modification is to use a derivative-free generating set direct search algorithm to solve the linearly constrained subproblems. The stopping criterion proposed by Conn, Gould, Sartenaer and Toint for the approximate solution of the subproblems requires explicit knowledge of derivatives. Such information is presumed absent in the generating set search method we employ. Instead, we show that stationarity results for linearly constrained generating set search methods provide a derivative-free stopping criterion, based on a step-length control parameter, that is sufficient to preserve the convergence properties of the original augmented Lagrangian algorithm.

  2. Signal processing related to the vestibulo-ocular reflex during combined angular rotation and linear translation of the head

    Science.gov (United States)

    McCrea, R. A.; Chen-Huang, C.; Peterson, B. W. (Principal Investigator)

    1999-01-01

    The contributions of vestibular nerve afferents and central vestibular pathways to the angular (AVOR) and linear (LVOR) vestibulo-ocular reflex were studied in squirrel monkeys during fixation of near and far targets. Irregular vestibular afferents did not appear to be necessary for the LVOR, since when they were selectively silenced with galvanic currents the LVOR was essentially unaffected during both far- and near-target viewing. The linear translation signals generated by secondary AVOR neurons in the vestibular nuclei were, on average, in phase with head velocity, inversely related to viewing distance, and were nearly as strong as AVOR-related signals. We suggest that spatial-temporal transformation of linear head translation signals to angular eye velocity commands is accomplished primarily by the addition of viewing distance multiplied, centrally integrated, otolith regular afferent signals to angular VOR pathways.

  3. Combining Convex-Concave Decompositions and Linearization Approaches for solving BMIs, with application to Static Output Feedback

    CERN Document Server

    Dinh, Quoc Tran; Michiels, Wim; Diehl, Moritz

    2011-01-01

    A novel optimization method is proposed to minimize a convex function subject to bilinear matrix inequality (BMI) constraints. The key idea is to decompose the bilinear mapping as a difference between two positive semidefinite convex mappings. At each iteration of the algorithm the concave part is linearized, leading to a convex subproblem.Applications to various output feedback controller synthesis problems are presented. In these applications the subproblem in each iteration step can be turned into a convex optimization problem with linear matrix inequality (LMI) constraints. The performance of the algorithm has been benchmarked on the data from COMPleib library.

  4. Controlled parallel crystallization of lithium disilicate and diopside using a combination of internal and surface nucleation

    Science.gov (United States)

    Rampf, Markus; Dittmer, Marc; Ritzberger, Christian; Höland, Wolfram

    2016-10-01

    In the mid-19th century, Dr. Donald Stookey identified the importance and usability of nucleating agents and mechanisms for the development of glass-ceramic materials. Today, a number of various internal and surface mechanisms as well as combinations thereof have been established in the production of glass-ceramic materials. In order to create new innovative material properties the present study focuses on the precipitation of CaMgSiO6 as a minor phase in Li2Si2O5 based glass-ceramics. In the base glass of the SiO2-Li2O-P2O5-Al2O3-K2O-MgO-CaO system P2O5 serves as nucleating agent for the internal precipitation of Li2Si2O5 crystals while a mechanical activation of the glass surface by means of ball milling is necessary to nucleate the minor CaMgSi2O6 crystal phase. For a successful precipitation of CaMgSi2O6 a minimum ratio of MgO and CaO in the range between 1.4 mol% and 2.9 mol% in the base glasses was determined. The nucleation and crystallization of both crystal phases takes place during sintering a powder compact. Dependent on the quality of the sintering process the dense Li2Si2O5-CaMgSi2O6 glass-ceramics show a mean biaxial strength of up to 392 ± 98 MPa. The microstructure of the glass-ceramics is formed by large (5-10 µm) bar like CaMgSi2O6 crystals randomly embedded in a matrix of small (≤ 0.5 µm) plate like Li2Si2O5 crystals arranged in an interlocking manner. While there is no significant influence of the minor CaMgSi2O6 phase on the strength of the material, the translucency of the material decreases upon precipitation of the minor phase.

  5. Combined study of microwave-power-dependence and linear-polarization-dependence of the microwave-radiation-induced magnetoresistance oscillations

    Science.gov (United States)

    Ye, Tianyu; Liu, Han-Chun; Mani, Ramesh; Wegscheider, Werner; Georgia State University Collaboration; ETH Zurich Collaboration

    2014-03-01

    Microwave radiation induced magnetoresistance oscillations (MRIMOs) represent an interesting electrical property of the high mobility two dimensional electron gas (2DEG) at low temperatures in a perpendicular magnetic field and under microwave excitation. Some questions under discussion in this topic include: (a) whether MRIMOs' amplitudes grow linearly with the microwave power and (b) how the MRIMO amplitudes change with the rotation of the microwave polarization with respect to the sample. In this study, we utilize swept microwave power and continuously changed linear polarized microwave polarization angle as two variables in four-terminal low-frequency lock-in magnetoresistance measurements of the 2DEG samples. The results show that amplitude of MRIMOs varies non-linearly with the microwave power. Also, the microwave polarization dependence measurements show that MRIMOs depend sensitively on the polarization angle of the linearly polarized microwaves, while the oscillatory magnetoresistance follows a cosine square function of the polarization angle. We provide a simple model that conveys our understanding of our observations. Basic research at Georgia State University is supported by the DOE-BES, MSE Division under DE-SC0001762. Microwave work is supported by the ARO under W911NF-07-01-0158.

  6. [Bone substitutes augmentation combined with internal fixation versus internal fixation alone in treating proximal femoral fractures in the elderly: a meta-analysis].

    Science.gov (United States)

    Wu, Jian-bin; Yang, Lei; Zhou, Fei-ya; Feng, Yong-zeng

    2016-06-01

    To systematically review the effectiveness of bone substitute augmentation combined with internal fixation versus internal fixation alone in treating proximal femoral fractures in the elderly. Subject term and keywords were searched from Pubmed, Cochrane databases and CNKI from database foundation to August 2015. Randomized controlled studies and qusi-randomized controlled studies on bone substitutes augmentation combined with internal fixation versus internal fixation alone for the treatment of proximal femoral fractures in the elderly were chosen. Postoperative re-displacement, re-operation rate, complications (infection and bone ununion), functional outcome, quality of life scores and muscle strength were seen as outcome indicators. Enumeration data were statistical analyzed by risk difference and 95% confidence interval. Measurement data were analyzed by standardized mean difference and 95% confidence interval. If the same measurement data were evaluated by different standards in different studies, standardized mean differences and 95% confidence interval were used. The methods of statistical analysis were used by Cochrane databases. Eleven RCTs (677 patients) were included. Meta-analysis results indicated that bone substitutes augmentation combined with internal fixation occurred fewer re-displacement [SMD = -0.75, 95% CI (-1.03, -0.47)] and obtained better function [SMD = 0.40, 95% CI (0.20, 0.59)]. While there were no significant differences in reoperation rate [RD = 0.02, 95% CI (-0.05, -0.09)], pain at 1 week after operation [MD = -1.79, 95% CI (-13.55, -9.96)], pain ranged from 6 to 8 weeks [MD = -7.24, 95% CI (-20.07, -5.59)], postoperative pain at 12 weeks [MD = -0.32, 95% CI (-4.9, -3.55)], muscle strength [MD = 1.25, 95% CI (-6.98, -9.48)], bone ununion [RD = 0.02, 95% CI (-0.01, -0.05)] and postoperative complications [MD = 0.01, 95% CI (-0.03, -0.04)]. Compared with single internal fixation, bone substitutes augmentation combined with internal

  7. Radical resection for low rectal carcinoma combined with infusion pump chemotherapy via internal iliac artery

    Directory of Open Access Journals (Sweden)

    Bo YANG

    2011-10-01

    Full Text Available Objective To evaluate the effects and practicability of radical resection for low rectal carcinoma with infusion pump chemotherapy via internal iliac artery,and explore the correlation factors influencing the therapeutic effects.Methods Data of 316 patients with low rectal carcinoma,admitted from Oct.1997 to Mar.2008,were retrospectively analyzed and assigned into 2 groups according to the treatment: Patients received infusion pump chemotherapy via internal iliac artery to target area combined with intravenous systemic chemotherapy were assigned into group A(n=249,and those receiving systemic chemotherapy alone following radical resection were assigned to group B(n=67.The timing of pump chemotherapy to target area in group A was set at day 12 after recovery of digestive function,with regimen of 5-FU at 0.5g per dose plus hydroxycamptothecin at 10-15mg per dose,twice a week,four times as a treatment course for a total of 6 courses,and it was followed by intravenously systemic chemotherapy with a regimen of FOLFIRI or FOLFOX.In group B,at day 12 right after recovery of digestive function,the intravenous sytemic chemotherapy was started with the same regimen as in group A.The local recurrence rate,metastasis rate and survival rate after 1,3 and 5 years in the two groups were respectively observed and compared,and the correlation between the clinicopathological features and the 5 year local recurrence rates and survival rates was analyzed in patients of group A.Results In group A,the local recurrence rate at year 1,3 and 5 was 0,1.68%(4/238 and 3.79%(8/211,respectively,the metastasis rate was 0.80%(2/249,4.62%(11/238 and 10.90%(23/211,respectively,and the survival rate was 100%,77.73%(185/238 and 72.04%(152/211,respectively.In group B,the local recurrence rate at year 1,3 and 5 was 0,9.52%(6/63 and 16.36%(9/55,respectively,the metastasis rate was 1.49%(1/67,15.87%(10/63 and 27.27%(15/55,respectively,and the survival rate was 100

  8. Why combine diet and physical activity in the same international research society?

    Directory of Open Access Journals (Sweden)

    Baranowski Tom

    2004-02-01

    Full Text Available Abstract Research in diet and physical activity in the U.S. started in very different traditions, with behavioral science input being uneven in their development. Investigators and policy makers in Europe have recognized the complementarity of diet and physical activity and incorporated them both under the label Public Health Nutrition. Joining these disciplines internationally offers the opportunity to benefit all, since the problems addressed are human, not specific to any one country. In regard to why combine diet and physical activity, at the biological level, there is reason to believe that diet and physical activity working in concert can remodel physiological structures and processes toward healthful ends. The diet and physical activity behaviors themselves vary in characteristics and are similar in others. The behavioral science components of these two disciplines face similar problems, and can learn from the advances made by the other, in the areas of measurement, correlates and intervention. By working together, knowledge will be enhanced from uncovering complementary and interactive relationships between diet and physical activity, and in relation to disease risks, that may result in designing more effective and efficient interventions and policies. Since the behavioral sciences are at a disadvantage in comparison to the biological sciences in terms of scientific advances and thereby capturing the popular imagination for solutions to health problems, we must redouble our efforts to enhance funding for behavioral research in regard to diet and physical activity and to make the research advances necessary to prevent the medicalizing of essentially social and behavioral problems. Nutrition and physical activity should most effectively do this together.

  9. A Meta-Analysis for Postoperative Complications in Tibial Plafond Fracture: Open Reduction and Internal Fixation Versus Limited Internal Fixation Combined With External Fixator.

    Science.gov (United States)

    Wang, Dong; Xiang, Jian-Ping; Chen, Xiao-Hu; Zhu, Qing-Tang

    2015-01-01

    The treatment of tibial plafond fractures is challenging to foot and ankle surgeons. Open reduction and internal fixation and limited internal fixation combined with an external fixator are 2 of the most commonly used methods of tibial plafond fracture repair. However, conclusions regarding the superior choice remain controversial. The present meta-analysis aimed to quantitatively compare the postoperative complications between open reduction and internal fixation and limited internal fixation combined with an external fixator for tibial plafond fractures. Nine studies with 498 fractures in 494 patients were included in the present study. The meta-analysis found no significant differences in bone healing complications (risk ratio [RR] 1.17, 95% confidence interval [CI] 0.68 to 2.01, p = .58], nonunion (RR 1.09, 95% CI 0.51 to 2.36, p = .82), malunion or delayed union (RR 1.24, 95% CI 0.57 to 2.69, p = .59), superficial (RR 1.56, 95% CI 0.43 to 5.61, p = .50) and deep (RR 1.89, 95% CI 0.62 to 5.80) infections, arthritis symptoms (RR 1.20, 95% CI 0.92 to 1.58, p = .18), or chronic osteomyelitis (RR 0.31, 95% CI 0.05 to 1.84, p = .20) between the 2 groups. Copyright © 2015 American College of Foot and Ankle Surgeons. Published by Elsevier Inc. All rights reserved.

  10. Combining Linear-Scaling DFT with Subsystem DFT in Born-Oppenheimer and Ehrenfest Molecular Dynamics Simulations: From Molecules to a Virus in Solution.

    Science.gov (United States)

    Andermatt, Samuel; Cha, Jinwoong; Schiffmann, Florian; VandeVondele, Joost

    2016-07-12

    In this work, methods for the efficient simulation of large systems embedded in a molecular environment are presented. These methods combine linear-scaling (LS) Kohn-Sham (KS) density functional theory (DFT) with subsystem (SS) DFT. LS DFT is efficient for large subsystems, while SS DFT is linear scaling with a smaller prefactor for large sets of small molecules. The combination of SS and LS, which is an embedding approach, can result in a 10-fold speedup over a pure LS simulation for large systems in aqueous solution. In addition to a ground-state Born-Oppenheimer SS+LS implementation, a time-dependent density functional theory-based Ehrenfest molecular dynamics (EMD) using density matrix propagation is presented that allows for performing nonadiabatic dynamics. Density matrix-based EMD in the SS framework is naturally linear scaling and appears suitable to study the electronic dynamics of molecules in solution. In the LS framework, linear scaling results as long as the density matrix remains sparse during time propagation. However, we generally find a less than exponential decay of the density matrix after a sufficiently long EMD run, preventing LS EMD simulations with arbitrary accuracy. The methods are tested on various systems, including spectroscopy on dyes, the electronic structure of TiO2 nanoparticles, electronic transport in carbon nanotubes, and the satellite tobacco mosaic virus in explicit solution.

  11. Exploring survey participation, data combination, and research validity in a substance use study: an application of hierarchical linear modeling.

    Science.gov (United States)

    Orsi, Rebecca; Chapman, Phillip L; Edwards, Ruth W

    2010-01-01

    A sound decision regarding combination of datasets is critical for research validity. Data were collected between 1996 and 2000 via a 99-item survey of substance use behaviors. Two groups of 7th-12th grade students in predominately White communities are compared: 166,578 students from 193 communities with high survey participation and 41,259 students from 65 communities with lower participation. Hierarchical logistic models are used to explore whether the two datasets may be combined for further study of community-level substance use effects. "Scenario analysis" is introduced. Results suggest the datasets may reasonably be combined. Limitations and further research are discussed.

  12. Combination therapy with acipimox enhances the effect of growth hormone treatment on linear body growth in the normal and small-for-gestational-age rat.

    Science.gov (United States)

    Vickers, M H; Hofman, P L; Gluckman, P D; Lobie, P E; Cutfield, W S

    2006-12-01

    Growth hormone (GH) therapy is often associated with adverse side effects, including impaired insulin sensitivity. GH treatment of children with idiopathic short stature does not lead to an optimized final adult height. It has been demonstrated that FFA reduction induced by pharmacological antilipolysis can stimulate GH secretion per se in both normal subjects and those with GH deficiency. However, to date, no investigation has been undertaken to establish efficacy of combination treatment with GH and FFA regulators on linear body growth. Using a model of maternal undernutrition in the rat to induce growth-restricted offspring, we investigated the hypothesis that combination treatment with GH and FFA regulators can enhance linear body growth above that of GH alone. At postnatal day 28, male offspring of normally nourished mothers (controls) and offspring born with low birth weight [small for gestational age (SGA)] were treated with saline, GH, or GH (5 mg.kg(-1).day(-1)) in combination with acipimox (GH + acipimox, 20 mg.kg(-1).day(-1)) or fenofibrate (GH + fenofibrate, 30 mg.kg(-1).day(-1)) for 40 days. GH plus acipimox treatment significantly enhanced linear body growth in the control and SGA animals above that of GH, as quantified by tibial and total body length. Treatment with GH significantly increased fasting plasma insulin, insulin-to-glucose ratio, and plasma volumes in control and SGA animals but was not significantly different between saline and GH-plus-acipimox-treated animals. GH-induced lipolysis was blocked by GH plus acipimox treatment in both control and SGA animals, concomitant with a significant reduction in fasting plasma FFA and insulin concentrations. This is the first study to show that GH plus acipimox combination therapy, via pharmacological blocking of lipolysis during GH exposure, can significantly enhance the efficacy of GH in linear growth promotion and ameliorate unwanted metabolic side effects.

  13. Localizing internal friction along the reaction coordinate of protein folding by combining ensemble and single-molecule fluorescence spectroscopy.

    Science.gov (United States)

    Borgia, Alessandro; Wensley, Beth G; Soranno, Andrea; Nettels, Daniel; Borgia, Madeleine B; Hoffmann, Armin; Pfeil, Shawn H; Lipman, Everett A; Clarke, Jane; Schuler, Benjamin

    2012-01-01

    Theory, simulations and experimental results have suggested an important role of internal friction in the kinetics of protein folding. Recent experiments on spectrin domains provided the first evidence for a pronounced contribution of internal friction in proteins that fold on the millisecond timescale. However, it has remained unclear how this contribution is distributed along the reaction and what influence it has on the folding dynamics. Here we use a combination of single-molecule Förster resonance energy transfer, nanosecond fluorescence correlation spectroscopy, microfluidic mixing and denaturant- and viscosity-dependent protein-folding kinetics to probe internal friction in the unfolded state and at the early and late transition states of slow- and fast-folding spectrin domains. We find that the internal friction affecting the folding rates of spectrin domains is highly localized to the early transition state, suggesting an important role of rather specific interactions in the rate-limiting conformational changes.

  14. Clique-Based Clustering of Correlated SNPs in a Gene Can Improve Performance of Gene-Based Multi-Bin Linear Combination Test

    Directory of Open Access Journals (Sweden)

    Yun Joo Yoo

    2015-01-01

    Full Text Available Gene-based analysis of multiple single nucleotide polymorphisms (SNPs in a gene region is an alternative to single SNP analysis. The multi-bin linear combination test (MLC proposed in previous studies utilizes the correlation among SNPs within a gene to construct a gene-based global test. SNPs are partitioned into clusters of highly correlated SNPs, and the MLC test statistic quadratically combines linear combination statistics constructed for each cluster. The test has degrees of freedom equal to the number of clusters and can be more powerful than a fully quadratic or fully linear test statistic. In this study, we develop a new SNP clustering algorithm designed to find cliques, which are complete subnetworks of SNPs with all pairwise correlations above a threshold. We evaluate the performance of the MLC test using the clique-based CLQ algorithm versus using the tag-SNP-based LDSelect algorithm. In our numerical power calculations we observed that the two clustering algorithms produce identical clusters about 40~60% of the time, yielding similar power on average. However, because the CLQ algorithm tends to produce smaller clusters with stronger positive correlation, the MLC test is less likely to be affected by the occurrence of opposing signs in the individual SNP effect coefficients.

  15. Clique-Based Clustering of Correlated SNPs in a Gene Can Improve Performance of Gene-Based Multi-Bin Linear Combination Test.

    Science.gov (United States)

    Yoo, Yun Joo; Kim, Sun Ah; Bull, Shelley B

    2015-01-01

    Gene-based analysis of multiple single nucleotide polymorphisms (SNPs) in a gene region is an alternative to single SNP analysis. The multi-bin linear combination test (MLC) proposed in previous studies utilizes the correlation among SNPs within a gene to construct a gene-based global test. SNPs are partitioned into clusters of highly correlated SNPs, and the MLC test statistic quadratically combines linear combination statistics constructed for each cluster. The test has degrees of freedom equal to the number of clusters and can be more powerful than a fully quadratic or fully linear test statistic. In this study, we develop a new SNP clustering algorithm designed to find cliques, which are complete subnetworks of SNPs with all pairwise correlations above a threshold. We evaluate the performance of the MLC test using the clique-based CLQ algorithm versus using the tag-SNP-based LDSelect algorithm. In our numerical power calculations we observed that the two clustering algorithms produce identical clusters about 40~60% of the time, yielding similar power on average. However, because the CLQ algorithm tends to produce smaller clusters with stronger positive correlation, the MLC test is less likely to be affected by the occurrence of opposing signs in the individual SNP effect coefficients.

  16. Power and sample size for the S:T repeated measures design combined with a linear mixed-effects model allowing for missing data.

    Science.gov (United States)

    Tango, Toshiro

    2017-02-13

    Tango (Biostatistics 2016) proposed a new repeated measures design called the S:T repeated measures design, combined with generalized linear mixed-effects models and sample size calculations for a test of the average treatment effect that depend not only on the number of subjects but on the number of repeated measures before and after randomization per subject used for analysis. The main advantages of the proposed design combined with the generalized linear mixed-effects models are (1) it can easily handle missing data by applying the likelihood-based ignorable analyses under the missing at random assumption and (2) it may lead to a reduction in sample size compared with the simple pre-post design. In this article, we present formulas for calculating power and sample sizes for a test of the average treatment effect allowing for missing data within the framework of the S:T repeated measures design with a continuous response variable combined with a linear mixed-effects model. Examples are provided to illustrate the use of these formulas.

  17. Analysis of High-Frequency Broadband Acoustic Scattering from Non-Linear Internal Waves During SW06

    Science.gov (United States)

    2009-09-30

    and Love, 1996; Nero et al., 1998; Love et al., 2004). The broadband system developed for this project was used to measure high-frequency broadband...2550. Love, R. H., Fisher, R. A., Wilson, M. A., and Nero , R.W. (2004). “Unusual swimbladder behavior of fish in the Cariaco Trench,” Deep-Sea...strained by internal solitary waves propagating shoreward over the continental shelf,” J. Phys. Oceanogr. 33, 2093-2112. Nero , R.W., Thompson, C.H., and

  18. Exciter system identification and automatic tuning of linear combination-type power system stabilizers Prony analysis; Prony kaiseki ni motozuku reijikei no dotei to hiritsu kasangata PSS no jido sekkei hoho

    Energy Technology Data Exchange (ETDEWEB)

    Amano, M.; Watanabe, M.; Banjo, M. [Hitachi, Ltd., Tokyo (Japan)

    1997-07-01

    The objective of this paper is to present anew automatic tuning method of power system stabilizers using Prony analysis. Irony analysis is used for detecting oscillation frequency, damping, phase, and amplitude from power oscillation waveform data. By applying the method to the waveform data of stabilizing signal and internal induced voltage, exciter system phase lag and oscillation frequency can be identified, and control parameters are decided using the identified values. Linear combination-type power system stabilizers are effective for damping low frequency oscillations using two control input signals, generator power and bus voltage frequency. The control parameters can be directly derived from the oscillation frequency and the excitation system phase lag without using phase compensation. Simulation results show that the proposed method is effective both in one machine-infinite bus system and in a multimachine system. The method can be used for off-line controller design and also for on-line adaptive control. 9 refs., 15 figs., 4 tabs.

  19. Status and future developments of the International Linear Collider%国际直线对撞机研究现状及未来发展

    Institute of Scientific and Technical Information of China (English)

    高杰

    2011-01-01

    文章介绍了国际直线对撞机(ILC)的科学目标及直线对撞机(LC)与强子对撞机(LHC)的关系.结合对正负电子直线对撞机历史的回顾及国际直线对撞机方案的选择,对国际直线对撞机的发展现状及未来发展趋势进行了介绍.对中国科学家在国际直线对撞机中所做的国际合作研究进行了简要的回顾,并强调了中国抓住国际直线对撞机国际合作机遇对中国科学发展的重要性.%The scientific goals of the International Linear Collider (ILC) and its relationship with the Large Hadron Collider are introduced. The history of linear colliders and ILC, as well as the prospects of ILC, are reviewed. A summary of China's participation in international collaboration in the ILC program is given, with stress on the important opportunities it provides for China's scientific development.

  20. Experimental performance investigation of glazing system combined with internal roller blinds

    DEFF Research Database (Denmark)

    Larsen, Olena Kalyanova; Jensen, Rasmus Lund; Iversen, Tore Dahl

    2016-01-01

    Modern low-energy buildings are often associated with efficient shading devices, as an inevitable component to reduce the peak heat gain in the building and to improve visual comfort. Internal shading devices may have inferior performance compared to external shading, but these are still the most...... used in practice due to lower cost, simplicity and better acceptance between architects and users. The interplay between glazing systems and internal shading devices has been studied and in everyday practice this interplay is described by the solar shading coefficient and the total g...

  1. Internal and external radiative widths in the combined R-matrix and potential model formalism

    CERN Document Server

    Mukhamedzhanov, A M; Bertulani, C A; Hao, T V Nhan

    2016-01-01

    Using the $R$-matrix approach we calculate the radiative width for a resonance decaying to a bound state through electric dipole, $E1$, transitions. The total radiative width is determined by the interference of the nuclear internal and external radiative width amplitudes. For a given channel radius the external radiative width amplitude is model independent and is determined by the asymptotic normalization coefficient (ANC) of the bound state to which the resonance decays. It also depends on the partial resonance width. To calculate the internal radiative width amplitude we show that a single particle potential model is appropriate. We compare our results with a few experimental data.

  2. Simulation of groundwater level variations using wavelet combined with neural network, linear regression and support vector machine

    Science.gov (United States)

    Ebrahimi, Hadi; Rajaee, Taher

    2017-01-01

    Simulation of groundwater level (GWL) fluctuations is an important task in management of groundwater resources. In this study, the effect of wavelet analysis on the training of the artificial neural network (ANN), multi linear regression (MLR) and support vector regression (SVR) approaches was investigated, and the ANN, MLR and SVR along with the wavelet-ANN (WNN), wavelet-MLR (WLR) and wavelet-SVR (WSVR) models were compared in simulating one-month-ahead of GWL. The only variable used to develop the models was the monthly GWL data recorded over a period of 11 years from two wells in the Qom plain, Iran. The results showed that decomposing GWL time series into several sub-time series, extremely improved the training of the models. For both wells 1 and 2, the Meyer and Db5 wavelets produced better results compared to the other wavelets; which indicated wavelet types had similar behavior in similar case studies. The optimal number of delays was 6 months, which seems to be due to natural phenomena. The best WNN model, using Meyer mother wavelet with two decomposition levels, simulated one-month-ahead with RMSE values being equal to 0.069 m and 0.154 m for wells 1 and 2, respectively. The RMSE values for the WLR model were 0.058 m and 0.111 m, and for WSVR model were 0.136 m and 0.060 m for wells 1 and 2, respectively.

  3. Combining rigorous diffraction calculation and GPU accelerated nonsequential raytracing for high precision simulation of a linear grating spectrometer

    Science.gov (United States)

    Mauch, Florian; Fleischle, David; Lyda, Wolfram; Osten, Wolfgang; Krug, Torsten; Häring, Reto

    2011-05-01

    Simulation of grating spectrometers constitutes the problem of propagating a spectrally broad light field through a macroscopic optical system that contains a nanostructured grating surface. The interest of the simulation is to quantify and optimize the stray light behaviour, which is the limiting factor in modern high end spectrometers. In order to accomplish this we present a simulation scheme that combines a RCWA (rigorous coupled wave analysis) simulation of the grating surface with a selfmade GPU (graphics processor unit) accelerated nonsequential raytracer. Using this, we are able to represent the broad spectrum of the light field as a superposition of many monochromatic raysets and handle the huge raynumber in reasonable time.

  4. Combining neural and behavioral indicators in the assessment of internalizing psychopathology in children and adolescents.

    Science.gov (United States)

    Moser, Jason S; Durbin, C Emily; Patrick, Christopher J; Schmidt, Norman B

    2015-01-01

    Anxiety and mood disorders are among the most prevalent mental health problems affecting our youth. We propose that assessment and treatment efforts in this area can benefit from a focus on developmentally sensitive neurobehavioral trait constructs, that is, individual difference constructs with direct referents in both neurobiology and behavior across the lifespan. This approach dovetails with the National Institute of Mental Health's Research Domain Criteria initiative, which aims to improve classification and treatment of psychopathology by delineating dimensions of functioning that transcend measurement domains and traditional diagnostic categories. We highlight two neurobehavioral dimensions with clear relevance for understanding internalizing problems at differing ages: (a) defensive reactivity and (b) cognitive control. Individual differences in defensive reactivity are posited to reflect variations in sensitivity of the brain's negative valence systems, whereas differences in cognitive control are theorized to reflect variations in neural systems dedicated to regulating behavior and affect. Focusing on these target constructs, we illustrate a psychoneurometric approach to assessment of internalizing psychopathology entailing use of neural, self-report, and behavioral indicators. We address the feasibility of the psychoneurometric approach for clinical application and present results from a pilot study demonstrating expected associations for neural, parent-report, and behavioral measures of defensive reactivity and cognitive control with internalizing symptoms in preschoolers. Together, our conceptual and empirical analyses highlight the promise of multimethod, dimensional assessment of internalizing psychopathology in the lab and in the clinic.

  5. The Harmonic Calculation of Novel Linear Combination Sampling SPWM%新型线性组合采样法SPWM谐波数值分析

    Institute of Scientific and Technical Information of China (English)

    严海龙; 王榕生

    2012-01-01

    This article first illustrates the shortcoming of the asymmetric regular sampling SPWM, it requires a large sampling numbers, and so occupy a large processor resources. Then a detailed analysis of the linear combination sampling method to solve this problem is given. Through the comparison of symmetric regular sampling method and two-vertex sampling method, this article leads to novel linear combination sampling method, and then uses Matlab numerical calculation functions for harmonic analysis of several sampling SPWM wave, also finally gives a few key procedures in the analysis process. The analysis results validated the linear combination sampling method, it also proved that the two-vertex sampling method is not practical.%阐明了常用的不对称规则采样法SPWM的采样次数多、占用处理器资源大的问题,详细分析了能够解决这一问题的线性组合采样法的整体原理。通过双顶点采样法与对称规则采样法的比较,引出新型线性组合采样法,并利用Matlab强大的数值计算功能对几种采样法SPWM波行进行谐波分析,同时给出了分析过程中的关键程序段。分析结果证明了线性组合采样法的有效性,也证明了双顶点采样法是不实用的。

  6. Determining large deflections in rectangular combined loaded cantilever beams made of non-linear Ludwick type material by means of different arc length assumptions

    Indian Academy of Sciences (India)

    Ibrahim Eren

    2008-02-01

    In this study, large deflection of cantilever beams of Ludwick type material subjected to a combined loading consisting of a uniformly distributed load and one vertical concentrated load at the free end was investigated. In calculations, both material and geometrical non-linearity have been considered. Horizontal and vertical deflections magnitudes were calculated throughout Euler–Bernoulli curvature-moment relationship assuming different arc lengths. Vertical deflections were calculated by using Runge–Kutta method. More simple and easily understandable results have been obtained compared to the previous studies about the issue and compatible values have been obtained for most of the compared values.

  7. Experimental performance investigation of glazing system combined with internal roller blinds

    DEFF Research Database (Denmark)

    Larsen, Olena Kalyanova; Jensen, Rasmus Lund; Iversen, Tore Dahl;

    2016-01-01

    is carried out by experimental work in a full-scale test facility, the Cube, with two types of window (double and triple glazed) and two types of solar shading: highly reflective roller blind and highly absorbing roller blind. Danish Building simulation software, BSim is used to illustrate the scale......-value of the system (window + roller blind). Solar shading coefficient in such practice is assumed to be independent of the window properties and solar incidence angle. This paper is aimed to illustrate the deviation between the actual and assumed performance of the window system with internal roller blind. This task...... of deviation between the experimental results and the results obtained with common assumptions for solar properties of shading device. It is concluded that the solar shading coefficient for an internal roller blind, as a standalone parameter, is not good enough to describe the solar properties of the system...

  8. Management of intra-articular fracture of the fingers via mini external fixator combined with limited internal fixation

    Institute of Scientific and Technical Information of China (English)

    LI Wen-jun; TIAN Wen; TIAN Guang-lei; CHEN Shan-lin; ZHANG Chang-qing; XUE Yun-hao; LI Zhong-zhe; ZHU Yin

    2009-01-01

    Background Intra-articular fractures of the fingers are common problems to emergency physicians and hand surgeons.Inappropriate management of these injuries may result in chronic pain,stiffness,deformity,or post traumatic arthritis.Ideal treatment necessitates the restoration of a stable and congruent joint that will allow early mobilization.The purpose of this study was to investigate the results of intra-articular fracture of the fingers by mini external fixator combined with limited internal fixation.Methods From May 2005 to May 2007,a total of 26 patients with intra-articular fracture of the fingers were treated by mini external fixator combined with limited internal fixation.Of the 26 cases,11 involved in metacarpophalangeal joint,and 15 interphalangeal joint in proximal interphalangeal.Kirschner wire,mini wire and absorbable suture were used for limited internal fixation.All patients were followed up and patients were accomplished with total active motion(TAM)of fingers.Results All patients were reviewed by an independent observer.The mean follow up was 13 months(range 9 to 24 months).Subjective,objective and radiographic results were evaluated.X-ray films revealed fracture union and the average radiographic union time was 7 weeks with a range of 5-12 weeks and the phalange shortening or rotation in 2 cases,joint incongruity(less than 1 mm)and joint space narrowing in 3 cases respectively.Phalangeal shortening or rotation was observed in 2 cases and joint incongruity or joint space narrowing was observed in 3 cases.An artificial implant was performed on one case for traumatic arthritis 1.5 years after surgery.Based on TAM the overall good-excellent rate of joint motion function was 80.8%.Conclusion Mini external fixator combined with limited internal fixation is a reliable and effective method for treatment of intra-articular fracture of the fingers.

  9. 5th International Workshop on Combinations of Intelligent Methods and Applications

    CERN Document Server

    Palade, Vasile; Prentzas, Jim

    2017-01-01

    Complex problems usually cannot be solved by individual methods or techniques and require the synergism of more than one of them to be solved. This book presents a number of current efforts that use combinations of methods or techniques to solve complex problems in the areas of sentiment analysis, search in GIS, graph-based social networking, intelligent e-learning systems, data mining and recommendation systems. Most of them are connected with specific applications, whereas the rest are combinations based on principles. Most of the chapters are extended versions of the corresponding papers presented in CIMA-15 Workshop, which took place in conjunction with IEEE ICTAI-15, in November 2015. The rest are invited papers that responded to special call for papers for the book. The book is addressed to researchers and practitioners from academia or industry, who are interested in using combined methods in solving complex problems in the above areas.

  10. Validation of a method to differentiate arterial and venous vessels in CT perfusion data using linear combinations of quantitative time-density curve characteristics

    Energy Technology Data Exchange (ETDEWEB)

    Havla, Lukas; Schneider, Moritz; Dietrich, Olaf [Ludwig-Maximilians-University Hospital Munich, Josef Lissner Laboratory for Biomedical Imaging, Institute for Clinical Radiology, Munich (Germany); Thierfelder, Kolja M.; Beyer, Sebastian E.; Ertl-Wagner, Birgit; Sommer, Wieland H. [Ludwig-Maximilians-University Hospital Munich, Institute for Clinical Radiology, Munich (Germany)

    2015-10-15

    We aimed to develop and evaluate a new method that reliably differentiates between cerebral arteries and veins using voxel-wise CT-perfusion-derived parameters. Fourteen consecutive patients with suspected stroke but without pathological findings were examined on a multi-detector CT system: 32 dynamic phases (∇t = 1.5 s) during application of 35 mL iomeprol-350 were acquired at 80 kV/200mAs. Three hemodynamic parameters were calculated for 18 arterial and venous vessel segments: A (maximum of the time-density-curve), T (time-to-peak), and W (full-width-at-half-maximum). Using receiver operator characteristic (ROC) curve analysis and Fisher's linear discriminant analysis (FLDA), the performance of every classifier (A, T, W) and of all linear combinations for the differentiation of arterial and venous vessels was determined. A maximum area under the ROC-curve (AUC) of 0.945 (accuracy = 86.8 %) was obtained using the FLDA combination of A and T or the triplet FLDA of A and T and W for the classification of venous and arterial vessels. The best single parameter was T with an AUC of 0.871 (accuracy = 79.0 %), which performed significantly worse than the combination A and T (p < 0.001). Arteries and veins can be accurately differentiated based on dynamic CT perfusion data using the maximum of the time-density curve, its time-to-peak, its width, and FLDA combinations of these parameters, which yield accuracies up to 87 %. (orig.)

  11. School Enterprises: Combining Vocational Learning with Production. International Project on Technical and Vocational Education (UNEVOC).

    Science.gov (United States)

    Singh, Madhu

    Trends in combining learning and production were examined through case studies of school enterprises in 11 countries: China, India, Indonesia, Papua New Guinea, Germany, Botswana, Kenya, Ghana, Algeria, Cuba, and Costa Rica. The study focused on the following: types and structures of school enterprises; organization of learning; competency…

  12. Study of the neutralino sector and analysis of the muon response of a highly granular hadron calorimeter at the International Linear Collider

    Energy Technology Data Exchange (ETDEWEB)

    D' Ascenzo, Nicola

    2009-01-15

    The studies presented in this thesis concern the physics potential and the detector R and D program of the International Linear Collider (ILC), an e{sup +}e{sup -} collider with a centre of mass energy extendible up to 1 TeV. The first part of the thesis presents the study of the neutralino system in the SPS1a SUSY scenario. The process e{sup +}e{sup -}{yields}{mu}{sub L}{mu}{sub L}{yields}{mu}{chi}{sub 1}{sup 0}{mu}{chi}{sub 1}{sup 0} is proposed for the analysis of the {chi}{sub 1}{sup 0}. From the kinematic edges of the energy distribution of the muons in the final state the mass of the {chi}{sub 1}{sup 0} (97.71 GeV) can be estimated with a relative statistical uncertainty of 1.09%. The mass of the {mu}{sub L} (189.87 GeV) can be estimated with a relative statistical uncertainty of 0.21%. The cross section of this process (54.32 fb) can be estimated with a relative statistical uncertainty of 2.47% at 68% C.L. The {chi}{sub 2}{sup 0} is investigated in the process e{sup +}e{sup -}{yields}{chi}{sub 2}{sup 0}{chi}{sub 1}{sup 0}{yields}{mu}{sub R}{mu}{yields}{chi}{sub 1}{sup 0}{mu}{mu}{chi}{sub 1}{sup 0}. The mass of the {chi}{sub 2}{sup 0} (183.89 GeV) is estimated with a relative statistical uncertainty of 0.75% from the detection of the kinematic edge of the di-muon invariant mass. The cross section of the process (4.2 fb) can be determined within the confidence band (3.75, 5.57) fb, at 95% C.L. The second part of the thesis reports the analysis of the experimental data collected in the test beam of the prototype of a highly granular hadronic calorimeter (AHCAL) build by the CALICE collaboration. The aim of the analysis is to measure the response of the hadronic calorimeter to muons with momentum ranging between 6 GeV and 120 GeV and incidence angle up to 28.3 {+-}0.1 . The energy and angular dependence of the muon response are found in agreement with the Monte Carlo. The effects of the higher order electromagnetic interaction of muons in the detector are

  13. Comparisons of external fixator combined with limited internal fixation and open reduction and internal fixation for Sanders type 2 calcaneal fractures: Finite element analysis and clinical outcome.

    Science.gov (United States)

    Pan, M; Chai, L; Xue, F; Ding, L; Tang, G; Lv, B

    2017-07-01

    The aim of this study was to compare the biomechanical stability and clinical outcome of external fixator combined with limited internal fixation (EFLIF) and open reduction and internal fixation (ORIF) in treating Sanders type 2 calcaneal fractures. Two types of fixation systems were selected for finite element analysis and a dual cohort study. Two fixation systems were simulated to fix the fracture in a finite element model. The relative displacement and stress distribution were analysed and compared. A total of 71 consecutive patients with closed Sanders type 2 calcaneal fractures were enrolled and divided into two groups according to the treatment to which they chose: the EFLIF group and the ORIF group. The radiological and clinical outcomes were evaluated and compared. The relative displacement of the EFLIF was less than that of the plate (0.1363 mm to 0.1808 mm). The highest von Mises stress value on the plate was 33% higher than that on the EFLIF. A normal restoration of the Böhler angle was achieved in both groups. No significant difference was found in the clinical outcome on the American Orthopedic Foot and Ankle Society Ankle Hindfoot Scale, or on the Visual Analogue Scale between the two groups (p > 0.05). Wound complications were more common in those who were treated with ORIF (p = 0.028). Both EFLIF and ORIF systems were tested to 160 N without failure, showing the new construct to be mechanically safe to use. Both EFLIF and ORIF could be effective in treating Sanders type 2 calcaneal fractures. The EFLIF may be superior to ORIF in achieving biomechanical stability and less blood loss, shorter surgical time and hospital stay, and fewer wound complications.Cite this article: M. Pan, L. Chai, F. Xue, L. Ding, G. Tang, B. Lv. Comparisons of external fixator combined with limited internal fixation and open reduction and internal fixation for Sanders type 2 calcaneal fractures: Finite element analysis and clinical outcome. Bone Joint Res 2017

  14. Global atmospheric response to specific linear combinations of the main SST modes.. Part I: numerical experiments and preliminary results

    Science.gov (United States)

    Trzaska, S.; Moron, V.; Fontaine, B.

    1996-10-01

    This article investigates through numerical experiments the controversial question of the impact of El Niño-Southern Oscillation (ENSO) phenomena on climate according to large-scale and regional-scale interhemispheric thermal contrast. Eight experiments (two considering only inversed Atlantic thermal anomalies and six combining ENSO warm phase with large-scale interhemispheric contrast and Atlantic anomaly patterns) were performed with the Météo-France atmospheric general circulation model. The definition of boundary conditions from observed composites and principal components is presented and preliminary results concerning the month of August, especially over West Africa and the equatorial Atlantic are discussed. Results are coherent with observations and show that interhemispheric and regional scale sea-surface-temperature anomaly (SST) patterns could significantly modulate the impact of ENSO phenomena: the impact of warm-phase ENSO, relative to the atmospheric model intercomparison project (AMIP) climatology, seems stronger when embedded in global and regional SSTA patterns representative of the post-1970 conditions [i.e. with temperatures warmer (colder) than the long-term mean in the southern hemisphere (northern hemisphere)]. Atlantic SSTAs may also play a significant role. Acknowledgements. We gratefully appreciate the on-line DMSP database facility at APL (Newell et al., 1991) from which this study has benefited greatly. We wish to thank E. Friis-Christensen for his encouragement and useful discussions. A. Y. would like to thank the Danish Meteorological Institute, where this work was done, for its hospitality during his stay there and the Nordic Baltic Scholarship Scheme for its financial support of this stay. Topical Editor K.-H. Glassmeier thanks M. J. Engebretson and H. Lühr for their help in evaluating this paper.--> Correspondence to: A. Yahnin-->

  15. A combined AHP-GP model to allocate internal auditing time to projects

    Directory of Open Access Journals (Sweden)

    HA Kruger

    2006-06-01

    Full Text Available The optimal allocation of internal auditing time among competing projects is a multi-criteria problem that includes both qualitative and quantitative factors. This paper discusses an integrated approach where the analytic hierarchy process (AHP is used to deal with qualitative risk assessments and a goal programming (GP model to distribute available hours in such a way that risk is minimised. Additional considerations, such as maximum and minimum allowable project hours, risk reducing factors and risk levels, are also taken into account. Following a description of the models and framework, a brief case study is presented in which the framework was empirically evaluated.

  16. Accuracy of 1H magnetic resonance spectroscopy for quantification of 2-hydroxyglutarate using linear combination and J-difference editing at 9.4T.

    Science.gov (United States)

    Neuberger, Ulf; Kickingereder, Philipp; Helluy, Xavier; Fischer, Manuel; Bendszus, Martin; Heiland, Sabine

    2017-05-12

    Non-invasive detection of 2-hydroxyglutarate (2HG) by magnetic resonance spectroscopy is attractive since it is related to tumor metabolism. Here, we compare the detection accuracy of 2HG in a controlled phantom setting via widely used localized spectroscopy sequences quantified by linear combination of metabolite signals vs. a more complex approach applying a J-difference editing technique at 9.4T. Different phantoms, comprised out of a concentration series of 2HG and overlapping brain metabolites, were measured with an optimized point-resolved-spectroscopy sequence (PRESS) and an in-house developed J-difference editing sequence. The acquired spectra were post-processed with LCModel and a simulated metabolite set (PRESS) or with a quantification formula for J-difference editing. Linear regression analysis demonstrated a high correlation of real 2HG values with those measured with the PRESS method (adjusted R-squared: 0.700, p<0.001) as well as with those measured with the J-difference editing method (adjusted R-squared: 0.908, p<0.001). The regression model with the J-difference editing method however had a significantly higher explanatory value over the regression model with the PRESS method (p<0.0001). Moreover, with J-difference editing 2HG was discernible down to 1mM, whereas with the PRESS method 2HG values were not discernable below 2mM and with higher systematic errors, particularly in phantoms with high concentrations of N-acetyl-asparate (NAA) and glutamate (Glu). In summary, quantification of 2HG with linear combination of metabolite signals shows high systematic errors particularly at low 2HG concentration and high concentration of confounding metabolites such as NAA and Glu. In contrast, J-difference editing offers a more accurate quantification even at low 2HG concentrations, which outweighs the downsides of longer measurement time and more complex postprocessing. Copyright © 2017. Published by Elsevier GmbH.

  17. [Surgical treatment of anal stenosis following hemorrhoid surgery. Results of 150 combined mucosal advancement and internal sphincterotomy].

    Science.gov (United States)

    Carditello, Antonio; Milone, Antonino; Stilo, Francesco; Mollo, Francesco; Basile, Maurizio

    2002-01-01

    The aim of the study was to evaluate the efficacy of anoplasty by mucosal advancement combined with internal sphincterotomy for the treatment of iatrogenic anal stenosis. From January 1990 to December 2000, 149 patients with post-haemorrhoidectomy anal strictures underwent internal sphincterotomy and mucosal advancement flap anoplasty. Seventy-one percent of patients were operated on under local anaesthesia by perineal block according to Marti. In 90 percent of the patients, postoperative pain was mild. No significant complications were seen. The mean hospital stay was two days. Ninety-seven percent of patients were well satisfied with the surgical result one year after operation. Current surgical options for the treatment of post-haemorrhoidectomy anal stricture are reported and the advantages of mucosal advancement flap anoplasty outlined.

  18. SODI-COLLOID: a combination of static and dynamic light scattering on board the International Space Station.

    Science.gov (United States)

    Mazzoni, S; Potenza, M A C; Alaimo, M D; Veen, S J; Dielissen, M; Leussink, E; Dewandel, J-L; Minster, O; Kufner, E; Wegdam, G; Schall, P

    2013-04-01

    Microgravity research in space is a complex activity where the often scarce resources available for the launch, accommodation, and operation of instrumentation call for a careful experiment planning and instrument development. In this paper we describe a module of the Selectable Optical Diagnostic Instrument, that has been designed as a compact optical diagnostic instrument for colloidal physics experiments. The peculiarity of the instrument is the combination of a novel light scattering technique known as near field scattering and standard microscopy with a low-coherence laser light source. We describe its main design features, as well as measurement results on colloidal aggregation taken on the International Space Station.

  19. Design of an optical lens combined with a total internal reflection (TIR) freeform surface for a LED front fog lamp

    Science.gov (United States)

    Wang, Hong; Li, Xiufeng; Ge, Peng

    2017-02-01

    We propose a design method of an optical lens combined with a total internal reflection (TIR) freeform surface for a LED front fog lamp. The TIR freeform surface controls the edge rays of the LED source. It totally reflects the edge rays and makes them emit from the top surface of the lens. And the middle rays of the LED source go through the refractive surface and reach the measured plane. We simulate the model by Monte Carlo method. Simulation results show that the front fog lamp system can satisfy the requirement of ECE R19 Rev7. The light control efficiency can reach up to 76%.

  20. Non-parametric linear regression of discrete Fourier transform convoluted chromatographic peak responses under non-ideal conditions of internal standard method.

    Science.gov (United States)

    Korany, Mohamed A; Maher, Hadir M; Galal, Shereen M; Fahmy, Ossama T; Ragab, Marwa A A

    2010-11-15

    they might not be normally distributed. In addition, it could effectively circumvent any outlier data points. For the purpose of comparison, the results obtained using the above described internal standard method were compared with the external standard method for all types of linearity.

  1. Combining interdisciplinary and International Medical Graduate perspectives to teach clinical and ethical communication using multimedia.

    Science.gov (United States)

    Woodward-Kron, Robyn; Flynn, Eleanor; Delany, Clare

    2011-01-01

    In Australia, international medical graduates (IMGs) play a crucial role in addressing workforce shortages in healthcare. Their ability to deliver safe and effective healthcare in an unfamiliar cultural setting is intrinsically tied to effective communication. Hospital-based medical clinical educators, who play an important role in providing communication training to IMGs, would benefit from practical resources and an understanding of the relevant pedagogies to address these issues in their teaching. This paper examines the nature of an interdisciplinary collaboration to develop multimedia resources for teaching clinical and ethical communication to IMGs. We describe the processes and dynamics of the collaboration, and outline the methodologies from applied linguistics, medical education, and health ethics that we drew upon. The multimedia consist of three video clips of challenging communication scenarios as well as experienced IMGs talking about communication and ethics. The multimedia are supported by teaching guidelines that address relevant disciplinary concerns of the three areas of collaboration. In the paper's discussion we point out the pre-conditions that facilitated the interdisciplinary collaboration. We propose that such collaborative approaches between the disciplines and participants can provide new perspectives to address the multifaceted challenges of clinical teaching and practice.

  2. Estimating biomass of mixed and uneven-aged forests using spectral data and a hybrid model combining regression trees and linear models

    Directory of Open Access Journals (Sweden)

    López-Serrano PM

    2016-04-01

    Full Text Available The Sierra Madre Occidental mountain range (Durango, Mexico is of great ecological interest because of the high degree of environmental heterogeneity in the area. The objective of the present study was to estimate the biomass of mixed and uneven-aged forests in the Sierra Madre Occidental by using Landsat-5 TM spectral data and forest inventory data. We used the ATCOR3® atmospheric and topographic correction module to convert remotely sensed imagery digital signals to surface reflectance values. The usual approach of modeling stand variables by using multiple linear regression was compared with a hybrid model developed in two steps: in the first step a regression tree was used to obtain an initial classification of homogeneous biomass groups, and multiple linear regression models were then fitted to each node of the pruned regression tree. Cross-validation of the hybrid model explained 72.96% of the observed stand biomass variation, with a reduction in the RMSE of 25.47% with respect to the estimates yielded by the linear model fitted to the complete database. The most important variables for the binary classification process in the regression tree were the albedo, the corrected readings of the short-wave infrared band of the satellite (2.08-2.35 µm and the topographic moisture index. We used the model output to construct a map for estimating biomass in the study area, which yielded values of between 51 and 235 Mg ha-1. The use of regression trees in combination with stepwise regression of corrected satellite imagery proved a reliable method for estimating forest biomass.

  3. Bone radiofrequency ablation combined with prophylactic internal fixation for metastatic bone tumor of the femur from hepatocellular carcinoma.

    Science.gov (United States)

    Ogura, Koichi; Miyake, Ryoko; Shiina, Shuichiro; Shinoda, Yusuke; Okuma, Tomotake; Kobayashi, Hiroshi; Goto, Takahiro; Nakamura, Kozo; Kawano, Hirotaka

    2012-08-01

    A 64-year-old man with 6-year history of hepatocellular carcinoma (HCC) was referred to us regarding bone metastasis to the right proximal femur. Although he underwent radiotherapy for pain palliation and local tumor control, the pain persisted and the tumor relapsed 3 months after the radiotherapy and he was thought to be at high risk of pathologic fracture. Given hypervascularity and large tumor size, a prophylactic internal fixation combined with adjuvant radiofrequency ablation (RFA) was proposed to reduce blood loss and prevent viable tumor cells being disseminated. His postoperative course was uneventful without requiring blood transfusion and preoperative symptoms immediately disappeared after surgery. He became capable of weight-bearing walk with a single cane and was almost asymptomatic without local progression on the plain radiographs when he died 14 months after surgery. Combination therapy of RFA and internal fixation using intramedullary nailing for metastases of the long bones from HCC seems to be a very promising technique both for sufficient pain relief and for local control of the tumor. Adjuvant RFA may become a potential option for patients with metastases of the long bones for the purpose of prevention of tumor dissemination and reduction of intraoperative blood loss.

  4. Electronic states and optical properties of GaAs/AlAs and GaAs/vacuum superlattices by the linear combination of bulk bands method

    Energy Technology Data Exchange (ETDEWEB)

    Botti, S.; Andreani, L. C.

    2001-06-15

    The linear combination of bulk bands method recently introduced by Wang, Franceschetti, and Zunger [Phys. Rev. Lett. >78, 2819 (1997)] is applied to a calculation of energy bands and optical constants of (GaAs){sub n}/(AlAs){sub n} and (GaAs){sub n}/(vacuum){sub n} (001) superlattices with n ranging from 4 to 20. Empirical pseudopotentials are used for the calculation of the bulk energy bands. Quantum-confinement-induced shifts of critical point energies are calculated and are found to be larger for the GaAs/vacuum system. The E{sub 1} peak in the absorption spectra has a blueshift and splits into two peaks for decreasing superlattice period; the E{sub 2} transition instead is found to be split for large-period GaAs/AlAs superlattices. The band contribution to linear birefringence of GaAs/AlAs superlattices is calculated and compared with recent experimental results of Sirenko [Phys. Rev. B >60, 8253 (1999)]. The frequency-dependent part reproduces the observed increase with decreasing superlattice period, while the calculated zero-frequency birefringence does not account for the experimental results and points to the importance of local-field effects.

  5. Solid phase microextraction of diclofenac using molecularly imprinted polymer sorbent in hollow fiber combined with fiber optic-linear array spectrophotometry.

    Science.gov (United States)

    Pebdani, Arezou Amiri; Shabani, Ali Mohammad Haji; Dadfarnia, Shayessteh; Khodadoust, Saeid

    2015-08-05

    A simple solid phase microextraction method based on molecularly imprinted polymer sorbent in the hollow fiber (MIP-HF-SPME) combined with fiber optic-linear array spectrophotometer has been applied for the extraction and determination of diclofenac in environmental and biological samples. The effects of different parameters such as pH, times of extraction, type and volume of the organic solvent, stirring rate and donor phase volume on the extraction efficiency of the diclofenac were investigated and optimized. Under the optimal conditions, the calibration graph was linear (r(2)=0.998) in the range of 3.0-85.0 μg L(-1) with a detection limit of 0.7 μg L(-1) for preconcentration of 25.0 mL of the sample and the relative standard deviation (n=6) less than 5%. This method was applied successfully for the extraction and determination of diclofenac in different matrices (water, urine and plasma) and accuracy was examined through the recovery experiments.

  6. Solid phase microextraction of diclofenac using molecularly imprinted polymer sorbent in hollow fiber combined with fiber optic-linear array spectrophotometry

    Science.gov (United States)

    Pebdani, Arezou Amiri; Shabani, Ali Mohammad Haji; Dadfarnia, Shayessteh; Khodadoust, Saeid

    2015-08-01

    A simple solid phase microextraction method based on molecularly imprinted polymer sorbent in the hollow fiber (MIP-HF-SPME) combined with fiber optic-linear array spectrophotometer has been applied for the extraction and determination of diclofenac in environmental and biological samples. The effects of different parameters such as pH, times of extraction, type and volume of the organic solvent, stirring rate and donor phase volume on the extraction efficiency of the diclofenac were investigated and optimized. Under the optimal conditions, the calibration graph was linear (r2 = 0.998) in the range of 3.0-85.0 μg L-1 with a detection limit of 0.7 μg L-1 for preconcentration of 25.0 mL of the sample and the relative standard deviation (n = 6) less than 5%. This method was applied successfully for the extraction and determination of diclofenac in different matrices (water, urine and plasma) and accuracy was examined through the recovery experiments.

  7. A new linearly-combined bi-exponential model for kinetic analysis of the isometric relaxation process of Bufo gastrocnemius under electric stimulation in vitro

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    There was a slow-relaxing tail of skeletal muscles in vitro upon the inhibition of Ca2+-pump by cyclopiazonic acid (CPA). Herein, a new linearly-combined bi-exponential model to resolve this slow-relaxing tail from the fast-relaxing phase was investigated for kinetic analysis of the isometric relaxation process of Bufo gastrocnemius in vitro, in comparison to the single exponential model and the classical bi-exponential model. During repetitive stimulations at a 2-s interval by square pulses of a 2-ms duration at 12 V direct currency (DC), the isometric tension of Bufo gastrocnemius was recorded at 100 Hz. The relaxation curve with tensions falling from 90% of the peak to the 15th datum before next stimulation was analyzed by three exponential models using a program in MATLAB 6.5. Both the goodness of fit and the distribution of the residuals for the best fitting supported the comparable validity of this new bi-exponential model for kinetic analysis of the relaxation process of the control muscles. After CPA treatment, however, this new bi-exponential model showed an obvious statistical superiority for kinetic analysis of the muscle relaxation process, and it gave the estimated rest tension consistent to that by experimentation, whereas both the classical bi-exponential model and the single exponential model gave biased rest tensions. Moreover, after the treatment of muscles by CPA, both the single exponential model and the classical bi-exponential model yielded lowered relaxation rates,nevertheless, this new bi-exponential model had relaxation rates of negligible changes except much higher rest tensions. These results suggest that this novel linearly-combined bi-exponential model is desirable for kinetic analysis of the relaxation process of muscles with altered Ca2+-pumping activity.

  8. Effect of rehabilitation exercise in combined with nutrition intervention on the postoperative rehabilitation after internal fixation of lower humerus fracture

    Institute of Scientific and Technical Information of China (English)

    Ming-Chao Zhang

    2016-01-01

    Objective:To explore the effect of rehabilitation exercise in combined with nutrition exercise on the elbow joint function after internal fixation of lower humerus fracture.Methods: A total of 80 patients with lower humerus fracture who were admitted in our hospital from July, 2014 to July, 2015 were included in the study and randomized into the intervention group and the control group. All the patients were preformed with internal fixation and given anti-infection, pain relieving, and anticoagulation treatments after operation. On this basis, the patients in the intervention group were given rehabilitation exercise in combined with nutrition exercise. The serum protein level 1 and 10 d after operation, and the elbow joint function recovery 12 months after operation in the two groups were compared.Results: The comparison of serum Hb, ALB, PA, and Ca 1d after operation between the two groups was not statistically significant. The serum Hb, ALB, and PA levels 10 d after operation were significantly elevated when compared with 1 d after operation. The serum Hb and PA levels 10 d after operation in the intervention group were significantly higher than those in the control group. With the extending of rehabilitation time, the various ROM of elbow joint was significantly increased when compared with before treatment. The total active motion of elbow joint flexion and extension, and forearm pronation and supination 3 and 6 months after follow-up visit in the intervention group was significantly superior to that in the control group.Conclusions:After internal fixation of lower humerus fracture, systemic rehabilitation and nutrition intervention should be taken as early as possible. Rehabilitation can effectively prevent the tissue adhesion around the joint, and promote the fracture healing and the recovery of joint function. Nutrition intervention can significantly improve the nutrition status, and is beneficial to the fracture healing.

  9. Internal motions in proteins: A combined neutron scattering and molecular modelling approach

    Indian Academy of Sciences (India)

    M-C Bellissent-Funel

    2004-07-01

    It is well-known that water plays a major role in the stability and catalytic function of proteins. Both the effect of hydration water on the dynamics of proteins and that of proteins on the dynamics of water have been studied using inelastic neutron scattering. Inelastic neutron scattering is the most direct probe of diffusive protein dynamics on the picosecond{nanosecond time-scale. We present here results relative to a photosynthetic globular protein, the C-phycocyanin, that can be obtained in protonated and deuterated forms. Diffusive motions have been studied using the protonated C-phycocyanin, protein. Molecular dynamics simulation and analytical theory have been combined to analyse the data and get a detailed description of diffusive motions for protein. The simulation-derived dynamic structure factors are in good agreement with experiment. The dynamical parameters are shown to present a smooth variation with distance from the core of the protein. The collective dynamics has been investigated using the fully deuterated C-phycocyanin protein. Both the experimental and calculated spectra exhibit a dynamic relaxation with a characteristic time of about 10 ps.

  10. Heat Transfer Computations of Internal Duct Flows With Combined Hydraulic and Thermal Developing Length

    Science.gov (United States)

    Wang, C. R.; Towne, C. E.; Hippensteele, S. A.; Poinsatte, P. E.

    1997-01-01

    This study investigated the Navier-Stokes computations of the surface heat transfer coefficients of a transition duct flow. A transition duct from an axisymmetric cross section to a non-axisymmetric cross section, is usually used to connect the turbine exit to the nozzle. As the gas turbine inlet temperature increases, the transition duct is subjected to the high temperature at the gas turbine exit. The transition duct flow has combined development of hydraulic and thermal entry length. The design of the transition duct required accurate surface heat transfer coefficients. The Navier-Stokes computational method could be used to predict the surface heat transfer coefficients of a transition duct flow. The Proteus three-dimensional Navier-Stokes numerical computational code was used in this study. The code was first studied for the computations of the turbulent developing flow properties within a circular duct and a square duct. The code was then used to compute the turbulent flow properties of a transition duct flow. The computational results of the surface pressure, the skin friction factor, and the surface heat transfer coefficient were described and compared with their values obtained from theoretical analyses or experiments. The comparison showed that the Navier-Stokes computation could predict approximately the surface heat transfer coefficients of a transition duct flow.

  11. Combined hardware--software considerations for triage of internally contaminated personnel.

    Science.gov (United States)

    Waller, Edward J

    2010-11-01

    Medical response to a radiological emergency involves first assessing, triaging and treating trauma, followed by determining potential hazard from radiological intake. A combined hardware-software strategy is required for this mission. The hardware strategy should consist of a dedicated detector suite capable of alpha, beta and gamma radiation detection, identification and quantification suitable for order of magnitude dose assessment. The hardware platform should provide a simple user interface suitable for field deployment. The software should provide first-on-the-scene responders with the ability to perform radiological triage in a mass casualty type event, physicians with the ability to assign treatment regimes, and long-term care medical personnel with information to provide continual risk reassessment of the patient taking into account toxicology of the decorporation therapy and dose aversion. The software should be rich in data, yet accessible through a simple user interface. Practicing in a radiological emergency exercise environment with the equipment is crucial to its efficacy in a real emergency.

  12. Internal motions in proteins: A combined neutron scattering and molecular modelling approach

    Science.gov (United States)

    Bellissent-Funel, M.-C.

    2004-07-01

    It is well-known that water plays a major role in the stability and catalytic function of proteins. Both the effect of hydration water on the dynamics of proteins and that of proteins on the dynamics of water have been studied using inelastic neutron scatter- ing. Inelastic neutron scattering is the most direct probe of diffusive protein dynamics on the picosecond-nanosecond time-scale. We present here results relative to a photosynthetic globular protein, the C-phycocyanin, that can be obtained in protonated and deuterated forms. Diffusive motions have been studied using the protonated C-phycocyanin, protein. Molecular dynamics simulation and analytical theory have been combined to analyse the data and get a detailed description of diffusive motions for protein. The simulation-derived dynamic structure factors are in good agreement with experiment. The dynamical param- eters are shown to present a smooth variation with distance from the core of the protein. The collective dynamics has been investigated using the fully deuterated C-phycocyanin protein. Both the experimental and calculated spectra exhibit a dynamic relaxation with a characteristic time of about 10 ps.

  13. Estimating Dbh of Trees Employing Multiple Linear Regression of the best Lidar-Derived Parameter Combination Automated in Python in a Natural Broadleaf Forest in the Philippines

    Science.gov (United States)

    Ibanez, C. A. G.; Carcellar, B. G., III; Paringit, E. C.; Argamosa, R. J. L.; Faelga, R. A. G.; Posilero, M. A. V.; Zaragosa, G. P.; Dimayacyac, N. A.

    2016-06-01

    Diameter-at-Breast-Height Estimation is a prerequisite in various allometric equations estimating important forestry indices like stem volume, basal area, biomass and carbon stock. LiDAR Technology has a means of directly obtaining different forest parameters, except DBH, from the behavior and characteristics of point cloud unique in different forest classes. Extensive tree inventory was done on a two-hectare established sample plot in Mt. Makiling, Laguna for a natural growth forest. Coordinates, height, and canopy cover were measured and types of species were identified to compare to LiDAR derivatives. Multiple linear regression was used to get LiDAR-derived DBH by integrating field-derived DBH and 27 LiDAR-derived parameters at 20m, 10m, and 5m grid resolutions. To know the best combination of parameters in DBH Estimation, all possible combinations of parameters were generated and automated using python scripts and additional regression related libraries such as Numpy, Scipy, and Scikit learn were used. The combination that yields the highest r-squared or coefficient of determination and lowest AIC (Akaike's Information Criterion) and BIC (Bayesian Information Criterion) was determined to be the best equation. The equation is at its best using 11 parameters at 10mgrid size and at of 0.604 r-squared, 154.04 AIC and 175.08 BIC. Combination of parameters may differ among forest classes for further studies. Additional statistical tests can be supplemented to help determine the correlation among parameters such as Kaiser- Meyer-Olkin (KMO) Coefficient and the Barlett's Test for Spherecity (BTS).

  14. Hybrid procedure combining clip on wrapping and stent placement for ruptured supraclinoid blood blister-like aneurysm of the internal carotid artery.

    Science.gov (United States)

    Nagasaki, Hirokazu; Narikiyo, Michihisa; Nagayama, Gota; Nagao, Seiya; Tsuboi, Yoshifumi; Kambayashi, Chisaku

    2017-03-01

    Blood blister-like aneurysms of the supraclinoid portion of the internal carotid artery are rare, fragile, and thin-walled lesions with a higher rate of rebleeding. Our case underwent a hybrid procedure combining direct surgical and endovascular approach.

  15. One-pot synthesis of cyclic aldol tetramer and,β-unsaturated aldol from linear aldehydes using quaternary ammonium combined with sodium hydroxide as catalysts

    Institute of Scientific and Technical Information of China (English)

    许海峰; 钟宏; 王帅; 李方旭

    2015-01-01

    One-pot synthesis of cyclic aldol tetramer anda,β-unsaturated aldol from C3−C8 linear aldehydes using phase-transfer catalyst (PTC), quaternary ammonium, combined with sodium hydroxide as catalysts was investigated. Butanal was subjected for detail investigations to study the effect of parameters. It was found that the selectivity of cyclic aldol tetramer depends greatly on the operating conditions of the reaction, especially the PTC/butanal molar ratio. The average selectivity of 2-hydroxy-6-propyl-l, 3, 5-triethyl-3-cyclohexene-1-carboxaldehyde (HPTECHCA) was 54.41% using tetrabutylammonium chloride combined with 14% (mass fraction) NaOH as catalysts at 60 °C for 2 h with a PTC-to-butanal molar ratio of 0.09:1. Pentanal was more likely to generate cyclic aldol tetramer compared with other aldehydes under the optimum experimental conditions. Recovery of the PTC through water washing followed by adding enough sodium hydroxide from the washings was also demonstrated.

  16. Measurement of the positron polarization at an helical undulator based positron source for the international linear collider ILC. The E-166 experiment at SLAC

    Energy Technology Data Exchange (ETDEWEB)

    Karim, Laihem

    2008-06-05

    A helical undulator based polarized positron source is forseen at a future International Linear Collider (ILC). The E-166 experiment has tested this scheme using a one meter long, short-period, pulsed helical undulator installed in the Final Focus Test Beam (FFTB) at SLAC. A low-emittance 46.6 GeV electron beam passing through this undulator generated circularly polarized photons with energies up to about 8 MeV. The generated photons of several MeV with circular polarization are then converted in a relatively thin target to generate longitudinally polarized positrons. Measurements of the positron polarization have been performed at 5 different energies of the positrons. In addition electron polarization has been determined for one energy point. For a comparison of the measured asymmetries with the expectations detailed simulations were necessary. This required upgrading GEANT4 to include the dominant polarization dependent interactions of electrons, positrons and photons in matter. The measured polarization of the positrons agrees with the expectations and is for the energy point with the highest polarization at 6MeV about 80%. (orig.)

  17. Photoproduction of Prompt $J/\\psi$ in Association with a $c\\bar{c}$ Pair within the Framework of Non-relativistic QCD at the International Linear Collider

    CERN Document Server

    Sun, Zhan; Zhang, Hong-Fei

    2015-01-01

    We present a systematical study on the photoproduction of prompt $J/\\psi$ in association with a $c\\bar{c}$ pair within the framework of non-relativistic QCD at the future high-energy $e^{+}e^{-}$ collider - International Linear Collider, including both direct and feed-down contributions. For direct $J/\\psi$ production, the states with color-octet $c\\bar{c}$-components, especially $|c\\bar{c}[^3P^{[8]}_J]g\\rangle$ and $|c\\bar{c}[^1S^{[8]}_0]g\\rangle$, provide dominant contribution to the production cross-section, which are about sixty times over that of the color-singlet state $|c\\bar{c}[^3S^{[1]}_1]\\rangle$. This is clearly shown by the transverse momentum ($p_t$) and rapidity distributions. The feed-down contribution from $\\psi'$ and $\\chi_{cJ}$ ($J=0,1,2$) is sizable, which is $\\sim 20\\%$ to the total prompt cross-section. Besides the yields, we also calculate the $J/\\psi$ polarization parameter $\\lambda$. In small $p_t$ region, the polarization of the prompt $J/\\psi$ is longitudinal due to $|c\\bar{c}[^3P^{[...

  18. Off-pump sequential bilateral internal mammary artery grafting combined with selective arterialization of the coronary venous system

    Institute of Scientific and Technical Information of China (English)

    YU Yang; YAN Xiao-lei; WEI Hua; YANG Jun-feng; GU Cheng-xiong

    2011-01-01

    Background Off-pump coronary artery bypass surgery (OPCAB) has been widely applied in recent years as a less invasive method of myocardial revascularization. This study evaluated the sequential bilateral internal mammary artery grafting combined with selective arterialization of the coronary venous system during OPCAB.Methods From April 2004 to August 2010, patients with diffuse right coronary lesions were studied retrospectively and divided into two groups. Group 1 included seventeen patients who underwent this surgery while group 2 included twenty-one patients without right coronary artery surgical therapy. All patients presented with symptoms of angina. Blood flow of bridged vessels was measured. The perioperative ventricular parameters including left ventricular ejection fraction and end diastolic diameter were compared. During follow-up, myocardial nuclide imaging and coronary angiography were carried out.Results Off-pump coronary artery bypass was performed with an average of 3.6 grafts per patient. Hospital mortality was zero. At the time of follow-up, the patients in group 1 recovered better than in group 2 (P<0.05). In both groups, the mean New York Heart Association (NYHA) class and ejection fraction increased significantly (P<0.001) and the mean left ventricular end-diastolic diameter decreased significantly (P <0.05). Myocardial blood supply of inferior wall in group 1 was obviously improved by myocardial nuclide imaging. Coronary angiography for eight patients in group 1 verified that there was blood flow to myocardium in the arterialized vein.Conclusions Sequential bilateral internal mammary artery grafting combined with selective arterialization of the coronary venous system can be performed during OPCAB. A postoperative improvement in the cardiac functions and the quality of life was documented, increasing our expectation for extensive application.

  19. Rethinking motor learning and savings in adaptation paradigms: model-free memory for successful actions combines with internal models.

    Science.gov (United States)

    Huang, Vincent S; Haith, Adrian; Mazzoni, Pietro; Krakauer, John W

    2011-05-26

    Although motor learning is likely to involve multiple processes, phenomena observed in error-based motor learning paradigms tend to be conceptualized in terms of only a single process: adaptation, which occurs through updating an internal model. Here we argue that fundamental phenomena like movement direction biases, savings (faster relearning), and interference do not relate to adaptation but instead are attributable to two additional learning processes that can be characterized as model-free: use-dependent plasticity and operant reinforcement. Although usually "hidden" behind adaptation, we demonstrate, with modified visuomotor rotation paradigms, that these distinct model-based and model-free processes combine to learn an error-based motor task. (1) Adaptation of an internal model channels movements toward successful error reduction in visual space. (2) Repetition of the newly adapted movement induces directional biases toward the repeated movement. (3) Operant reinforcement through association of the adapted movement with successful error reduction is responsible for savings. Copyright © 2011 Elsevier Inc. All rights reserved.

  20. Developing an International Combined Applied Surgical Science and Wet Lab Simulation Course as an Undergraduate Teaching Model

    Directory of Open Access Journals (Sweden)

    Michail Sideris

    2015-01-01

    Full Text Available Background. Essential Skills in the Management of Surgical Cases (ESMSC is an international, animal model-based course. It combines interactive lectures with basic ex vivo stations and more advanced wet lab modules, that is, in vivo dissections and Heart Transplant Surgery on a swine model. Materials and Methods. Forty-nine medical students (male, N=27, female N=22, and mean age = 23.7 years from King’s College London (KCL and Greek Medical Schools attended the course. Participants were assessed with Direct Observation of Procedural Skills (DOPS, as well as Multiple Choice Questions (MCQs. Paired t-test associations were used to evaluate whether there was statistically significant improvement in their performance. Aim. To evaluate the effectiveness of a combined applied surgical science and wet lab simulation course as a teaching model for surgical skills at the undergraduate level. Results. The mean MCQ score was improved by 2.33/32 (P<0.005. Surgical skills competences, as defined by DOPS scores, were improved in a statically significant manner (P<0.005 for all paired t-test correlations. Conclusions. ESMSC seems to be an effective teaching model, which improves the understanding of the surgical approach and the basic surgical skills. In vivo models could be used potentially as a step further in the Undergraduate Surgical Education.

  1. Simulation of nonlinear benchmarks and sheet metal forming processes using linear and quadratic solid–shell elements combined with advanced anisotropic behavior models

    Directory of Open Access Journals (Sweden)

    WangPeng

    2016-01-01

    Full Text Available A family of prismatic and hexahedral solid‒shell (SHB elements with their linear and quadratic versions is presented in this paper to model thin 3D structures. Based on reduced integration and special treatments to eliminate locking effects and to control spurious zero-energy modes, the SHB solid‒shell elements are capable of modeling most thin 3D structural problems with only a single element layer, while describing accurately the various through-thickness phenomena. In this paper, the SHB elements are combined with fully 3D behavior models, including orthotropic elastic behavior for composite materials and anisotropic plastic behavior for metallic materials, which allows describing the strain/stress state in the thickness direction, in contrast to traditional shell elements. All SHB elements are implemented into ABAQUS using both standard/quasi-static and explicit/dynamic solvers. Several benchmark tests have been conducted, in order to first assess the performance of the SHB elements in quasi-static and dynamic analyses. Then, deep drawing of a hemispherical cup is performed to demonstrate the capabilities of the SHB elements in handling various types of nonlinearities (large displacements and rotations, anisotropic plasticity, and contact. Compared to classical ABAQUS solid and shell elements, the results given by the SHB elements show good agreement with the reference solutions.

  2. Linear combination of one-step predictive information with an external reward in an episodic policy gradient setting: a critical analysis

    Directory of Open Access Journals (Sweden)

    Keyan eZahedi

    2013-11-01

    Full Text Available One of the main challenges in the field of embodied artificial intelligence is the open-ended autonomous learning of complex behaviours. Our approach is to use task-independent, information-driven intrinsic motivation(s to support task-dependent learning. The work presented here is a preliminary step in which we investigate the predictive information (the mutual information of the past and future of the sensor stream as an intrinsic drive, ideally supporting any kind of task acquisition. Previous experiments have shown that the predictive information (PI is a good candidate to support autonomous, open-ended learning of complex behaviours, because a maximisation of the PI corresponds to an exploration of morphology- and environment-dependent behavioural regularities. The idea is that these regularities can then be exploited in order to solve any given task. Three different experiments are presented and their results lead to the conclusion that the linear combination of the one-step PI with an external reward function is not generally recommended in an episodic policy gradient setting. Only for hard tasks a great speed-up can be achieved at the cost of an asymptotic performance lost.

  3. Restoring the Duality between Principal Components of a Distance Matrix and Linear Combinations of Predictors, with Application to Studies of the Microbiome

    Science.gov (United States)

    Tyx, Robert E.; Rivera, Angel J.; Stanfill, Stephen

    2017-01-01

    Appreciation of the importance of the microbiome is increasing, as sequencing technology has made it possible to ascertain the microbial content of a variety of samples. Studies that sequence the 16S rRNA gene, ubiquitous in and nearly exclusive to bacteria, have proliferated in the medical literature. After sequences are binned into operational taxonomic units (OTUs) or species, data from these studies are summarized in a data matrix with the observed counts from each OTU for each sample. Analysis often reduces these data further to a matrix of pairwise distances or dissimilarities; plotting the first two or three principal components (PCs) of this distance matrix often reveals meaningful groupings in the data. However, once the distance matrix is calculated, it is no longer clear which OTUs or species are important to the observed clustering; further, the PCs are hard to interpret and cannot be calculated for subsequent observations. We show how to construct approximate decompositions of the data matrix that pair PCs with linear combinations of OTU or species frequencies, and show how these decompositions can be used to construct biplots, select important OTUs and partition the variability in the data matrix into contributions corresponding to PCs of an arbitrary distance or dissimilarity matrix. To illustrate our approach, we conduct an analysis of the bacteria found in 45 smokeless tobacco samples. PMID:28085878

  4. Restoring the Duality between Principal Components of a Distance Matrix and Linear Combinations of Predictors, with Application to Studies of the Microbiome.

    Science.gov (United States)

    Satten, Glen A; Tyx, Robert E; Rivera, Angel J; Stanfill, Stephen

    2017-01-01

    Appreciation of the importance of the microbiome is increasing, as sequencing technology has made it possible to ascertain the microbial content of a variety of samples. Studies that sequence the 16S rRNA gene, ubiquitous in and nearly exclusive to bacteria, have proliferated in the medical literature. After sequences are binned into operational taxonomic units (OTUs) or species, data from these studies are summarized in a data matrix with the observed counts from each OTU for each sample. Analysis often reduces these data further to a matrix of pairwise distances or dissimilarities; plotting the first two or three principal components (PCs) of this distance matrix often reveals meaningful groupings in the data. However, once the distance matrix is calculated, it is no longer clear which OTUs or species are important to the observed clustering; further, the PCs are hard to interpret and cannot be calculated for subsequent observations. We show how to construct approximate decompositions of the data matrix that pair PCs with linear combinations of OTU or species frequencies, and show how these decompositions can be used to construct biplots, select important OTUs and partition the variability in the data matrix into contributions corresponding to PCs of an arbitrary distance or dissimilarity matrix. To illustrate our approach, we conduct an analysis of the bacteria found in 45 smokeless tobacco samples.

  5. Indoor radio channel modeling and mitigation of fading effects using linear and circular polarized antennas in combination for smart home system at 868 MHz

    Science.gov (United States)

    Wunderlich, S.; Welpot, M.; Gaspard, I.

    2014-11-01

    The markets for smart home products and services are expected to grow over the next years, driven by the increasing demands of homeowners considering energy monitoring, management, environmental controls and security. Many of these new systems will be installed in existing homes and offices and therefore using radio based systems for cost reduction. A drawback of radio based systems in indoor environments are fading effects which lead to a high variance of the received signal strength and thereby to a difficult predictability of the encountered path loss of the various communication links. For that reason it is necessary to derive a statistical path loss model which can be used to plan a reliable and cost effective radio network. This paper presents the results of a measurement campaign, which was performed in six buildings to deduce realistic radio channel models for a high variety of indoor radio propagation scenarios in the short range devices (SRD) band at 868 MHz. Furthermore, a potential concept to reduce the variance of the received signal strength using a circular polarized (CP) patch antenna in combination with a linear polarized antenna in an one-to-one communication link is presented.

  6. 试论公路线形组合对交通安全的影响%On the Influence of Highway Linear Combination on Transportation Safety

    Institute of Scientific and Technical Information of China (English)

    刘锋

    2015-01-01

    In recent years, with the guidance of the national transportation industry policy, the traffic mileage of various regions is showing a high growth momentum, at the same time, people pay more attention to the highway traffic safety situation. At this present, the most important things of the highway traffic safety are improving the level of the highway traffic safety and reducing the accident rate. In the highway traffic system, the transportation safety is eminently influenced and restricted by the factors of the road, especially the linear combination of highway, it directly influences the highway traffic safety situation.%近年来,在国家交通运输产业政策的引导下,各地公路通车里程都呈现出较高的增长态势,与此同时公路交通的安全状况也逐步引起了人们更多的关注。当前,提高公路交通安全水平,降低事故率成为公路交通安全的首要问题。在公路交通系统中,交通安全受“路”因素的影响和制约较突出,尤其是公路的线形组合,直接影响着公路交通的安全状况。

  7. Equations of state, transport properties, and compositions of argon plasma: combination of self-consistent fluid variation theory and linear response theory.

    Science.gov (United States)

    Quan, W L; Chen, Q F; Fu, Z J; Sun, X W; Zheng, J; Gu, Y J

    2015-02-01

    A consistent theoretical model that can be applied in a wide range of densities and temperatures is necessary for understanding the variation of a material's properties during compression and heating. Taking argon as an example, we show that the combination of self-consistent fluid variational theory and linear response theory is a promising route for studying warm dense matter. Following this route, the compositions, equations of state, and transport properties of argon plasma are calculated in a wide range of densities (0.001-20 g/cm(3)) and temperatures (5-100 kK). The obtained equations of state and electrical conductivities are found in good agreement with available experimental data. The plasma phase transition of argon is observed at temperatures below 30 kK and density about 2-6g/cm(3). The minimum density for the metallization of argon is found to be about 5.8 g/cm(3), occurring at 30-40 kK. The effects of many-particle correlations and dynamic screening on the electrical conductivity are also discussed through the effective potentials.

  8. Alternate approaches to future electron-positron linear colliders

    Energy Technology Data Exchange (ETDEWEB)

    Loew, G.A. [Stanford Univ., CA (United States). Stanford Linear Accelerator Center

    1998-07-01

    The purpose of this article is two-fold: to review the current international status of various design approaches to the next generation of e{sup +}e{sup {minus}} linear colliders, and on the occasion of his 80th birthday, to celebrate Richard B. Neal`s many contributions to the field of linear accelerators. As it turns out, combining these two tasks is a rather natural enterprise because of Neal`s long professional involvement and insight into many of the problems and options which the international e{sup +}e{sup {minus}} linear collider community is currently studying to achieve a practical design for a future machine.

  9. The multi-layered ring under parabolic distribution of radial stresses combined with uniform internal and external pressure

    Directory of Open Access Journals (Sweden)

    Christos F. Markides

    2017-04-01

    Full Text Available A recently introduced solution for the stress- and displacement-fields, developed in a multi-layered circular ring, composed of a finite number of linearly elastic concentric layers, subjected to a parabolic distribution of ra-dial stresses, is here extended to encompass a more general loading scheme, closer to actual conditions. The loading scheme includes, besides the para¬-bolic radial stresses, a combination of uniform pressures acting along the outer- and inner- most boundaries of the layered ring. The analytic solution of the problem is achieved by adopting Savin’s pioneering approach for an infinite plate with a hole strengthened by rings. Taking advantage of the results provided by the ana¬lytic solution, a numerical model, simulating the configuration of a three-layered ring (quite commonly encountered in practic¬al applications is validated. The numerical model is then used for a parametric analysis enlightening some crucial aspects of the overall response of the ring.

  10. Linearization Techniques

    Directory of Open Access Journals (Sweden)

    Gildeberto S. Cardoso

    2011-01-01

    Full Text Available This paper presents a study of linear control systems based on exact feedback linearization and approximate feedback linearization. As exact feedback linearization is applied, a linear controller can perform the control objectives. The approximate feedback linearization is required when a nonlinear system presents a noninvolutive property. It uses a Taylor series expansion in order to compute a nonlinear transformation of coordinates to satisfy the involutivity conditions.

  11. A novel method to establish a rat ED model using internal iliac artery ligation combined with hyperlipidemia.

    Directory of Open Access Journals (Sweden)

    Chao Hu

    Full Text Available OBJECTIVE: To investigate a novel method, namely using bilateral internal iliac artery ligation combined with a high-fat diet (BCH, for establishing a rat model of erectile dysfunction (ED that, compared to classical approaches, more closely mimics the chronic pathophysiology of human ED after acute ischemic insult. MATERIALS AND METHODS: Forty 4-month-old male Sprague Dawley rats were randomly placed into five groups (n = 8 per group: normal control (NC, bilateral internal iliac artery ligation (BIIAL, high-fat diet (HFD, BCH, and mock surgery (MS. All rats were induced for 12 weeks. Copulatory behavior, intracavernosal pressure (ICP, ICP/mean arterial pressure, hematoxylin-eosin staining, Masson's trichrome staining, serum lipid levels, and endothelial and neuronal nitric oxide synthase immunohistochemical staining of the cavernous smooth muscle and endothelium were assessed. Data were analyzed by SAS 8.0 for Windows. RESULTS: Serum total cholesterol and triglyceride levels were significantly higher in the HFD and BCH groups than the NC and MS groups. High density lipoprotein levels were significantly lower in the HFD and BCH groups than the NC and MS groups. The ICP values and mount and intromission numbers were significantly lower in the BIIAL, HFD, and BCH groups than in the NC and MS groups. ICP was significantly lower in the BCH group than in the BIIAL and HFD groups. Cavernous smooth muscle and endothelial damage increased in the HFD and BCH groups. Cavernous smooth muscle to collagen ratio, nNOS and eNOS staining decreased significantly in the BIIAL, HFD, and BCH groups compared to the NC and MS groups. CONCLUSIONS: The novel BCH model mimics the chronic pathophysiology of ED in humans and avoids the drawbacks of traditional ED models.

  12. Evaluation of internal mammary lymph nodes dissection combined with selective postoperative radiotherapy in patients with medial breast cancers

    Energy Technology Data Exchange (ETDEWEB)

    Yokota, Toru; Roppongi, Takashi; Kanno, Keiichi; Sakamoto, Ichiro; Fujii, Takanao; Mitomo, Osamu [Numata National Hospital, Gunma (Japan)

    1998-08-01

    In the reason that internal mammary lymph nodes (IMN) dissection of extended radical mastectomy (EXT) did not influence overall survival rates in patients with medial or central breast cancers, this procedure is seldom practiced in the European countries and the United States. But in the thought that IMN dissection combined with selective postoperative radiotherapy might increase disease-free or overall survival in these patients, this combined therapy in patients with medial breast cancers was evaluated. Thirty-five patients submitted to IMN dissection with extrapleural method and 114 patients submitted to non-dissection were evaluated in this study. Postoperative prophylactic radiotherapy (to IMN and supraclavicular lymph nodes) was administered to patients with histologically positive IMN or more than 4 of axillary lymph nodes. The dose of irradiation was 5000 to 5100 cGy given in 5 to 6 weeks. Patient characteristics in the two groups did not reveal any significant difference statistically. Statistical analysis was carried out both on disease-free survival and overall survival, computed from the date of radical surgery, by use of the Kaplan-Meier method. Both groups of survival were compared, using the Logrank test. The frequency of IMN metastasis is significantly associated with the one of axillary lymph nodes metastasis (p=0.03). The analysis of the percent disease-free survival related to the presence or absence of IMN dissection failed to reveal any significant difference (10 years of disease-free survival rate 56.1% and 74.5%, respectively). In the same way, the analysis of the percent overall survival failed to reveal any significant difference (10 years overall survival rate 58.8% and 80.4%, respectively). (author)

  13. Construction scheduled delay risk assessment by using combined AHP-RII methodology for an international NPP project

    Energy Technology Data Exchange (ETDEWEB)

    Hossen, Mufazal Muhammed; Kang, Sun Koo; Kim, Jong Hyun [KEPCO International Nuclear Graduate School (KINGS), Ulsan (Korea, Republic of)

    2015-04-15

    In this study, Nuclear Power Plant (NPP) construction schedule delay risk assessment methodology is developed and the construction delay risk is assessed for turnkey international NPP projects. Three levels of delay factors were selected through literature review and discussions with nuclear industry experts. A questionnaire survey was conducted on the basis of an analytic hierarchy process (AHP) and Relative Importance Index (RII) methods and the schedule delay risk is assessed qualitatively and quantitatively by severity and frequency of occurrence of delay factors. This study assigns four main delay factors to the first level: main contractor, utility, regulatory authority, and financial and country factor. The second and the third levels are designed with 12 sub-factors and 32 sub-sub-factors, respectively. This study finds the top five most important sub-sub-factors, which are as follows: policy changes, political instability and public intervention; uncompromising regulatory criteria and licensing documents conflicting with existing regulations; robust design document review procedures; redesign due to errors in design and design changes; and worldwide shortage of qualified and experienced nuclear specific equipment manufacturers. The proposed combined AHP-RII methodology is capable of assessing delay risk effectively and efficiently. Decision makers can apply risk informed decision making to avoid unexpected construction delays of NPPs.

  14. Non-Covalent Interactions and Internal Dynamics in Pyridine-Ammonia a Combined Quantum-Chemical and Microwave Spectroscopy Study

    Science.gov (United States)

    Spada, Lorenzo; Tasinato, Nicola; Vazart, Fanny; Barone, Vincenzo; Caminati, Walther; Puzzarini, Cristina

    2017-06-01

    The 1:1 complex of ammonia with pyridine has been characterized by using state-of-the-art quantum-chemical computations combined with pulsed-jet Fourier-Transform microwave spectroscopy. The computed potential energy landscape pointed out the formation of a stable σ-type complex, which has been confirmed experimentally: the analysis of the rotational spectrum showed the presence of only one 1:1 pyridine - ammonia adduct. Each rotational transition is split into several components due to the internal rotation of NH_3 around its C_3 axis and to the hyperfine structure of both ^{14}N quadrupolar nuclei, thus providing the unequivocal proof that the two molecules form a σ-type complex involving both a N-H\\cdotsN and a C-H\\cdotsN hydrogen bond. The dissociation energy (BSSE and ZPE corrected) has been estimated to be 11.5 kJ\\cdotmol^{-1}. This work represents the first application of an accurate, yet efficient computational scheme, designed for the investigation of small biomolecules, to a molecular cluster.

  15. X-ray absorption near edge structure/electron energy loss near edge structure calculation using the supercell orthogonalized linear combination of atomic orbitals method.

    Science.gov (United States)

    Ching, Wai-Yim; Rulis, Paul

    2009-03-11

    Over the last eight years, a large number of x-ray absorption near edge structure (XANES) and/or electron energy loss near edge structure (ELNES) spectroscopic calculations for complex oxides and nitrides have been performed using the supercell-OLCAO (orthogonalized linear combination of atomic orbitals) method, obtaining results in very good agreement with experiments. The method takes into account the core-hole effect and includes the dipole matrix elements calculated from ab initio wavefunctions. In this paper, we describe the method in considerable detail, emphasizing the special advantages of this method for large complex systems. Selected results are reviewed and several hitherto unpublished results are also presented. These include the Y K edge of Y ions segregated to the core of a Σ31 grain boundary in alumina, O K edges of water molecules, C K edges in different types of single walled carbon nanotubes, and the Co K edge in the cyanocobalamin (vitamin B(12)) molecule. On the basis of these results, it is argued that the interpretation of specific features of the calculated XANES/ELNES edges is not simple for complex material systems because of the delocalized nature of the conduction band states. The long-standing notion of the 'fingerprinting' technique for spectral interpretation of experimental data is not tenable. A better approach is to fully characterize the structure under study, using either crystalline data or accurate ab initio modeling. Comparison between calculated XANES/ELNES spectra and available measurements enables us to ascertain the validity of the modeled structure. For complex crystals or structures, it is necessary to use the weighted sum of the spectra from structurally nonequivalent sites for comparison with the measured data. Future application of the supercell-OLCAO method to complex biomolecular systems is also discussed.

  16. X-ray absorption near edge structure/electron energy loss near edge structure calculation using the supercell orthogonalized linear combination of atomic orbitals method

    Energy Technology Data Exchange (ETDEWEB)

    Ching, W.-Y.; Rulis, Paul [Department of Physics, University of Missouri-Kansas City, Kansas City, MO 64110 (United States)

    2009-03-11

    Over the last eight years, a large number of x-ray absorption near edge structure (XANES) and/or electron energy loss near edge structure (ELNES) spectroscopic calculations for complex oxides and nitrides have been performed using the supercell-OLCAO (orthogonalized linear combination of atomic orbitals) method, obtaining results in very good agreement with experiments. The method takes into account the core-hole effect and includes the dipole matrix elements calculated from ab initio wavefunctions. In this paper, we describe the method in considerable detail, emphasizing the special advantages of this method for large complex systems. Selected results are reviewed and several hitherto unpublished results are also presented. These include the Y K edge of Y ions segregated to the core of a {sigma}31 grain boundary in alumina, O K edges of water molecules, C K edges in different types of single walled carbon nanotubes, and the Co K edge in the cyanocobalamin (vitamin B{sub 12}) molecule. On the basis of these results, it is argued that the interpretation of specific features of the calculated XANES/ELNES edges is not simple for complex material systems because of the delocalized nature of the conduction band states. The long-standing notion of the 'fingerprinting' technique for spectral interpretation of experimental data is not tenable. A better approach is to fully characterize the structure under study, using either crystalline data or accurate ab initio modeling. Comparison between calculated XANES/ELNES spectra and available measurements enables us to ascertain the validity of the modeled structure. For complex crystals or structures, it is necessary to use the weighted sum of the spectra from structurally nonequivalent sites for comparison with the measured data. Future application of the supercell-OLCAO method to complex biomolecular systems is also discussed.

  17. X-ray absorption near edge structure/electron energy loss near edge structure calculation using the supercell orthogonalized linear combination of atomic orbitals method

    Science.gov (United States)

    Ching, Wai-Yim; Rulis, Paul

    2009-03-01

    Over the last eight years, a large number of x-ray absorption near edge structure (XANES) and/or electron energy loss near edge structure (ELNES) spectroscopic calculations for complex oxides and nitrides have been performed using the supercell-OLCAO (orthogonalized linear combination of atomic orbitals) method, obtaining results in very good agreement with experiments. The method takes into account the core-hole effect and includes the dipole matrix elements calculated from ab initio wavefunctions. In this paper, we describe the method in considerable detail, emphasizing the special advantages of this method for large complex systems. Selected results are reviewed and several hitherto unpublished results are also presented. These include the Y K edge of Y ions segregated to the core of a Σ31 grain boundary in alumina, O K edges of water molecules, C K edges in different types of single walled carbon nanotubes, and the Co K edge in the cyanocobalamin (vitamin B12) molecule. On the basis of these results, it is argued that the interpretation of specific features of the calculated XANES/ELNES edges is not simple for complex material systems because of the delocalized nature of the conduction band states. The long-standing notion of the 'fingerprinting' technique for spectral interpretation of experimental data is not tenable. A better approach is to fully characterize the structure under study, using either crystalline data or accurate ab initio modeling. Comparison between calculated XANES/ELNES spectra and available measurements enables us to ascertain the validity of the modeled structure. For complex crystals or structures, it is necessary to use the weighted sum of the spectra from structurally nonequivalent sites for comparison with the measured data. Future application of the supercell-OLCAO method to complex biomolecular systems is also discussed.

  18. Linear algebra

    CERN Document Server

    Shilov, Georgi E

    1977-01-01

    Covers determinants, linear spaces, systems of linear equations, linear functions of a vector argument, coordinate transformations, the canonical form of the matrix of a linear operator, bilinear and quadratic forms, Euclidean spaces, unitary spaces, quadratic forms in Euclidean and unitary spaces, finite-dimensional space. Problems with hints and answers.

  19. Linear Psoriasis

    Directory of Open Access Journals (Sweden)

    Agarwalla Arun

    2001-01-01

    Full Text Available Linear psoriasis, inflammatory linear varrucous epidermal naevus (ILVEN. Lichen straitus, linear lichen planus and invasion of epidermal naevi by psoriasis have clinical and histopathological overlap. We report two young male patients of true linear psoriasis without classical lesions elsewhere which were proved histopathologically. Seasonal variation and good response to topical antipsoriatic treatment supported the diagnosis.

  20. Linear- rubbing Manipulation

    Institute of Scientific and Technical Information of China (English)

    SHEN Guo-quan; XIAO Yuan-chun

    2003-01-01

    @@ Linear-rubbing is a characteristic technique in the academic school of internal exercise massage in Shanghai. It was known as "flat pushing method" in the past times. The academic school of internal exercise Tuina finds, in the clinical practice of flat pushing, that if the internal exercise accumuhtes in the palm and one-way movement is replaced by two-way movement, the kinetic energy may be transformed into heat energy, bringing about a new unique manipulating technique, which is rather different from the usual flat pushing no longer and now called linear-rubbing therapy.

  1. A new approach to design a control system for a FGR furnace using the combination of the CFD and linear system identification techniques

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, R.; Zhang, C.; Jiang, J. [University of Western Ontario, London, ON (Canada)

    2011-07-01

    A new approach to design control systems for an industrial furnace with flue gas recirculation (FGR) is presented. To facilitate the control system design, a linear dynamic model is needed for the furnace. Full-scale computational fluid dynamics (CFD) simulations are used to generate the required small signal input and output data sets. Subsequently, a least squares based system identification technique is used to obtained the linear dynamic models. After model validation, feedback controller is designed based on these linear dynamic models. Finally, the performance of the designed closed-loop control system is also evaluated using both linear dynamic model and full-scale nonlinear CFD model. The comparison shows that the control system designed using the proposed approach can minimize the deviation of nitric oxides (NO) emission from the design point by minimize the dynamic NO formation, hence to prevent any excessive NO formation in the combustion process when the system subjects to disturbances.

  2. Combining fluorescent in situ hybridization data with ISS staging improves risk assessment in myeloma: an International Myeloma Working Group collaborative project.

    Science.gov (United States)

    Avet-Loiseau, H; Durie, B G M; Cavo, M; Attal, M; Gutierrez, N; Haessler, J; Goldschmidt, H; Hajek, R; Lee, J H; Sezer, O; Barlogie, B; Crowley, J; Fonseca, R; Testoni, N; Ross, F; Rajkumar, S V; Sonneveld, P; Lahuerta, J; Moreau, P; Morgan, G

    2013-03-01

    The combination of serum β2-microglobulin and albumin levels has been shown to be highly prognostic in myeloma as the International Staging System (ISS). The aim of this study was to assess the independent contributions of ISS stage and cytogenetic abnormalities in predicting outcomes. A retrospective analysis of international studies looking at both ISS and cytogenetic abnormalities was performed in order to assess the potential role of combining ISS stage and cytogenetics to predict survival. This international effort used the International Myeloma Working Group database of 12 137 patients treated worldwide for myeloma at diagnosis, of whom 2309 had cytogenetic studies and 5387 had analyses by fluorescent in situ hybridization (iFISH). Comprehensive analyses used 2642 patients with sufficient iFISH data available. Using the comprehensive iFISH data, combining both t(4;14) and deletion (17p), along with ISS stage, significantly improved the prognostic assessment in terms of progression-free survival and overall survival. The additional impact of patient age and use of high-dose therapy was also demonstrated. In conclusion, the combination of iFISH data with ISS staging significantly improves risk assessment in myeloma.

  3. Combining fluorescent in situ hybridization data with ISS staging improves risk assessment in myeloma: an International Myeloma Working Group collaborative project

    Science.gov (United States)

    Avet-Loiseau, H; Durie, BGM; Cavo, M; Attal, M; Gutierrez, N; Haessler, J; Goldschmidt, H; Hajek, R; Lee, JH; Sezer, O; Barlogie, B; Crowley, J; Fonseca, R; Testoni, N; Ross, F; Rajkumar, SV; Sonneveld, P; Lahuerta, J; Moreau, P; Morgan, G

    2014-01-01

    The combination of serum β2-microglobulin and albumin levels has been shown to be highly prognostic in myeloma as the International Staging System (ISS). The aim of this study was to assess the independent contributions of ISS stage and cytogenetic abnormalities in predicting outcomes. A retrospective analysis of international studies looking at both ISS and cytogenetic abnormalities was performed in order to assess the potential role of combining ISS stage and cytogenetics to predict survival. This international effort used the International Myeloma Working Group database of 12 137 patients treated worldwide for myeloma at diagnosis, of whom 2309 had cytogenetic studies and 5387 had analyses by fluorescent in situ hybridization (iFISH). Comprehensive analyses used 2642 patients with sufficient iFISH data available. Using the comprehensive iFISH data, combining both t(4;14) and deletion (17p), along with ISS stage, significantly improved the prognostic assessment in terms of progression-free survival and overall survival. The additional impact of patient age and use of high-dose therapy was also demonstrated. In conclusion, the combination of iFISH data with ISS staging significantly improves risk assessment in myeloma. PMID:23032723

  4. PREFACE: International Conference on 'Quantum Control, Exact or Perturbative, Linear or Nonlinear' to celebrate 50 years of the scientific career of Professor Bogdan Mielnik (Mielnik50)

    Science.gov (United States)

    Bretón, N.; Fernández, D.; Kielanowski, P.

    2015-06-01

    The International Conference on 'Quantum Control, Exact or Perturbative, Linear or Nonlinear', took place in Mexico City on 22-24 October 2014. It was held with the aim of celebrating the first fifty years of scientific career of Bogdan Mielnik, an outstanding scientist whose professional trajectory spans over Poland and Mexico and who is currently Professor Emeritus in the Physics Department of Centro de Investigación y de Estudios Avanzados del IPN (Cinvestav) in Mexico. Bogdan Mielnik was born on May 6th, 1936 in Warsaw, Poland. He studied elementary and high school until 1953. In the autumn of 1953 he started the studies in the Faculty of Mathematics and Physics at the University of Warsaw, and at the end of 1957 he did his master work under the direction of Professor Jerzy Plebański. In 1962 he was invited to the newly opened Research Center of IPN (Cinvestav), in Mexico, as an assistant and PhD student of Jerzy Plebański. On October 22nd, 1964, he submitted to Cinvestav his PhD Thesis entitled ''Analytic functions of the displacement operator'', marking the offcial beginning of his scientific career. It is worth mentioning that Bogdan Mielnik is the first PhD graduate of the Physics Department of Cinvestav, so with this Conference our Department was also celebrating an important date on its calendar. A more detailed information can be found in the website http://www.fis.cinvestav.mx/mielnik50/. It was our great pleasure to see that many collaborators and former students of Bogdan Mielnik attended this Conference. The articles collected in this volume are the written contributions of the majority of talks presented at the conference. They have been organized according to the research subjects that Bogdan Mielnik has been involved in. Thus, the articles of JG Hirsch, L Hughston, G Morales-Luna, O Rosas-Ortiz and G Torres-Vega deal with Fundamental Problems in Quantum Mechanics. On the other hand, the papers by F Delgado, H Hernández-Coronado, G Herrera

  5. Finite-dimensional linear algebra

    CERN Document Server

    Gockenbach, Mark S

    2010-01-01

    Some Problems Posed on Vector SpacesLinear equationsBest approximationDiagonalizationSummaryFields and Vector SpacesFields Vector spaces Subspaces Linear combinations and spanning sets Linear independence Basis and dimension Properties of bases Polynomial interpolation and the Lagrange basis Continuous piecewise polynomial functionsLinear OperatorsLinear operatorsMore properties of linear operatorsIsomorphic vector spaces Linear operator equations Existence and uniqueness of solutions The fundamental theorem; inverse operatorsGaussian elimination Newton's method Linear ordinary differential eq

  6. Combining Vision with Voice: A Learning and Implementation Structure Promoting Teachers' Internalization of Practices Based on Self-Determination Theory

    Science.gov (United States)

    Assor, Avi; Kaplan, Haya; Feinberg, Ofra; Tal, Karen

    2009-01-01

    We propose that self-determination theory's conceptualization of internalization may help school reformers overcome the recurrent problem of "the predictable failure of educational reform" (Sarason, 1993). Accordingly, we present a detailed learning and implementation structure to promote teachers' internalization and application of ideas and…

  7. Applied linear regression

    CERN Document Server

    Weisberg, Sanford

    2013-01-01

    Praise for the Third Edition ""...this is an excellent book which could easily be used as a course text...""-International Statistical Institute The Fourth Edition of Applied Linear Regression provides a thorough update of the basic theory and methodology of linear regression modeling. Demonstrating the practical applications of linear regression analysis techniques, the Fourth Edition uses interesting, real-world exercises and examples. Stressing central concepts such as model building, understanding parameters, assessing fit and reliability, and drawing conclusions, the new edition illus

  8. The Application of Multi-objective Linear Programming in Guangzhou-Shenzhen Trains Combination%多目标线性规划在广深城际列车组合中的应用

    Institute of Scientific and Technical Information of China (English)

    翟俊格; 张原

    2012-01-01

    Use of multi-objective linear programming method and Guangzhou-Shenzhen trains combination products for the study. After establishing a mathematical model, with the analysis of LINGO software it can achieve the goal that Multi -objective linear programming is easier to be solve ;and make better use of more objective of linear programming to solve practical problems.%利用多目标线性规划的方法,以广深城际列车组合产品为研究对象.经过建立数学模型并采用LINGO软件分析,可以达到对多目标线性规划问题较易求解的目标,从而较好的利用多目标线性规划解决实际问题.

  9. Fatigue damage estimation in non-linear systems using a combination of Monte Carlo simulation and the First Order Reliability Method

    DEFF Research Database (Denmark)

    Jensen, Jørgen Juncher

    2015-01-01

    For non-linear systems the estimation of fatigue damage under stochastic loadings can be rather time-consuming. Usually Monte Carlo simulation (MCS) is applied, but the coefficient-of-variation (COV) can be large if only a small set of simulations can be done due to otherwise excessive CPU time. ...... the COV. For a specific example dealing with stresses in a tendon in a tension leg platform the COV is thereby reduced by a factor of three....

  10. [An attempt to combine humanitarianism and pacifism. The Red Cross and the Dutch movement for international peace].

    Science.gov (United States)

    van Bergen, L

    2001-01-01

    Both the International and the Dutch Red Cross were heavily damaged by World War II. The Red Cross movement especially was blamed for its lack of care for persecuted Jews and political prisoners. To restore its reputation all kinds of initiatives were taken. Amongst these was an attempt of the Dutch Red Cross to cooperate with several pacifist movements in the Dutch Movement for International Peace and Security. It seemed a good and sensible initiative, especially in 1945, but although it was supported by international Red Cross resolutions, it failed. The DRC grew immensely in numbers in the years after 1945. With the cold war coming up the peace movement lost most of its popularity and therefore lost its attraction for the Red Cross as a partner. As in the rest of its mutual history, the attempt to humanise war did not mix with the wish to abolish it.

  11. Linear Systems.

    Science.gov (United States)

    The report documents a series of seminars at Rome Air Development Center with the content equivalent to an intense course in Linear Systems . Material...is slanted toward the practicing engineer and introduces some of the fundamental concepts and techniques for analyzing linear systems . Techniques for

  12. Numerical analysis of convective drying of a moist object with combined internal and external heat and mass transfer

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Donghyun; Son, Gihun [Sogang University, Seoul (Korea, Republic of); Kim, Sungil [Korea Institute of Energy Research, Daejeon (Korea, Republic of)

    2016-02-15

    A numerical approach is developed for computing convective drying of a moist object. The conservation equations of mass, momentum, energy and moisture in the internal and external regions of an object are solved with the coupled heat and mass transfer conditions on the object surface, including the effect of evaporation. A numerical approach is applied to predict the internal and external temperature and moisture distributions during the convective drying with variations in the initial moisture content and the water activity. The numerical results show that the water activity is an important parameter for determining the drying rate pattern and the analogy between the heat and mass transfer on the object surface.

  13. A Procedure of Combination of Sequential Internal Thoracic Artery Grafting and Cooley's Technique for Complicated Case With Multi-vessel Disease,Left Ventricular Aneurysm and Mitral Regurgitation

    Institute of Scientific and Technical Information of China (English)

    Meng-ya LIANG; Guang-xian CHEN; Zhong-kai WU; Xi ZHANG

    2009-01-01

    @@ INTRODUCTION Left ventricular aneurysm and ischemic mitral regurgitation are two of most common complications of acute myocardial infarction (AMI).Combination of both these two fatal complications is not rare and the management of these complicated cases is always a challenge to cardiac surgeon because of its relatively high mortality[1]. We reported a rare case of AMI in which a singlestage correction of mitral valve replacement with preservation of mitral apparatus, sequential left internal thoracic artery (ITA) grafting and Cooley's technique.

  14. A combined stretching-tilting mechanism produces negative, zero and positive linear thermal expansion in a semi-flexible Cd(II)-MOF.

    Science.gov (United States)

    Lama, Prem; Das, Raj Kumar; Smith, Vincent J; Barbour, Leonard J

    2014-06-21

    A novel semi-flexible Cd(II)-MOF has been synthesized and characterized by variable temperature powder and single-crystal X-ray diffraction. The material displays an unusual combination of thermal expansion (TE) i.e. negative, zero and positive, which is an extremely rare finding, especially for metal-organic frameworks as a result of a combined stretching-tilting mechanism.

  15. MONITORING INTERNATIONAL MIGRATION FLOWS IN EUROPE - TOWARDS A STATISTICAL-DATA BASE COMBINING DATA FROM DIFFERENT SOURCES

    NARCIS (Netherlands)

    WILLEKENS, F

    1994-01-01

    The paper reviews techniques developed in demography, geography and statistics that are useful for bridging the gap between available data on international migration flows and the information required for policy making and research. The basic idea of the paper is as follows: to establish a coherent

  16. MONITORING INTERNATIONAL MIGRATION FLOWS IN EUROPE - TOWARDS A STATISTICAL-DATA BASE COMBINING DATA FROM DIFFERENT SOURCES

    NARCIS (Netherlands)

    WILLEKENS, F

    1994-01-01

    The paper reviews techniques developed in demography, geography and statistics that are useful for bridging the gap between available data on international migration flows and the information required for policy making and research. The basic idea of the paper is as follows: to establish a coherent

  17. Construction schedule delay risk assessment by using combined AHP-RII methodology for an international NPP project

    Directory of Open Access Journals (Sweden)

    Muhammed Mufazzal Hossen

    2015-04-01

    The proposed combined AHP-RII methodology is capable of assessing delay risk effectively and efficiently. Decision makers can apply risk informed decision making to avoid unexpected construction delays of NPPs.

  18. Combining of small fragment screws and large fragment plates for open reduction and internal fixation of periprosthetic humeral fractures.

    Science.gov (United States)

    Seybold, Dominik; Citak, Mustafa; Königshausen, Matthias; Gessmann, Jan; Schildhauer, Thomas A

    2011-10-01

    Operative treatment of periprosthetic humeral fractures in elderly patients with osteoporotic bone requires a stable fixations technique. The combination of 3.5 cortical screws with washers in a 4.5 Arbeitsgemeinschaft für Osteosynthesefragen, Limited-contact dynamic compression plate or Locking plate, allows a stable periprosthetic fixation with the small 3.5 screws and 4.5 screws above and below the prosthesis, respectively. This combination is a cost-effective technique to treat periprosthetic humeral fractures.

  19. Linear algebra

    CERN Document Server

    Stoll, R R

    1968-01-01

    Linear Algebra is intended to be used as a text for a one-semester course in linear algebra at the undergraduate level. The treatment of the subject will be both useful to students of mathematics and those interested primarily in applications of the theory. The major prerequisite for mastering the material is the readiness of the student to reason abstractly. Specifically, this calls for an understanding of the fact that axioms are assumptions and that theorems are logical consequences of one or more axioms. Familiarity with calculus and linear differential equations is required for understand

  20. Influence of the combined effect of magnetic field and rotation on the onset of a non-Newtonian viscoelastic nanofluid layer: Linear and nonlinear analyses

    Science.gov (United States)

    Khurana, Meenakshi; Rana, Puneet; Srivastava, Sangeet

    2016-12-01

    In the present paper, we present both linear and nonlinear analyses to investigate thermal instability on a rotating non-Newtonian viscoelastic nanofluid layer under the influence of a magnetic field. In the linear stability analysis, the stationary and oscillatory modes of convection are obtained for various controlling parameters using the normal mode technique. Both Nusselt and Sherwood numbers are calculated after employing the minimal truncated Fourier series to steady and unsteady state. The main findings conclude that rotation and strain retardation parameter increase the value of the critical Rayleigh number in the neutral stability curve which delays the onset of convection in the nanofluid layer while the stress relaxation parameter enhances the convection. The magnetic field stabilizes the system for low values of the Taylor number (rotation) but an inverse trend is observed for high Taylor number. Both Nusselt and Sherwood numbers initially oscillate with time until the steady state prevails and they decrease with both Chandrasekhar and Taylor numbers. The magnitude of the streamlines and the contours of both isotherms and iso-nanohalines concentrate near the boundaries for large values of Ra, indicating an increase in convection.

  1. Rapid quantification of four major bioactive alkaloids in Corydalis decumbens (Thunb.) Pers. by pressurised liquid extraction combined with liquid chromatography-triple quadrupole linear ion trap mass spectrometry.

    Science.gov (United States)

    Shen, Yan; Han, Chao; Jiang, Yongxiang; Zhou, Xiujin; Zhu, Zhenou; Lei, Xinxiang

    2011-05-30

    A new method based on pressurised liquid extraction (PLE) followed by liquid chromatography-triple quadrupole linear ion trap mass spectrometry (LC-QTrap-MS) analysis has been developed for the identification and quantification of four major alkaloids in extracts of Corydalis decumbens (Thunb.) Pers. PLE extractions were performed using 90% ethanol; temperature was set at 100°C and pressure at 1500 psi. HPLC analysis was performed on a Waters XBridge™ C(18) column (150 mm × 2.1mm i.d., 3.5 μm) eluted by a mobile phase of acetonitrile and 0.2% acetic acid. Data acquisition was carried out in multiple reaction monitoring transitions (MRMs) mode, monitoring two MRM transitions to ensure an accurate identification of target compounds in the samples. Additional identification and confirmation of target compounds were performed using the enhanced product ion modus (EPI) of the linear ion trap. The novel LC-QTrap-MS platform offers the best sensitivity and specificity for characterization and quantitative determination of the four alkaloids in C. decumbens (Thunb.) Pers. and fulfils the quality criteria for routine laboratory application.

  2. Non-linear imaging and characterization of atherosclerotic arterial tissue using combined two photon fluorescence, second-harmonic generation and CARS microscopy

    Science.gov (United States)

    Cicchi, Riccardo; Matthäus, Christian; Meyer, Tobias; Lattermann, Annika; Dietzek, Benjamin; Brehm, Bernhard R.; Popp, Jürgen; Pavone, Francesco S.

    2014-02-01

    Atherosclerosis is among the most widespread cardiovascular diseases and one of the leading cause of death in the Western World. Characterization of arterial tissue in atherosclerotic condition is extremely interesting from the diagnostic point of view. Routinely used diagnostic methods, such as histopathological examination, are limited to morphological analysis of the examined tissues, whereas an exhaustive characterization requires a morpho-functional approach. Multimodal non-linear microscopy has the potential to bridge this gap by providing morpho-functional information on the examined tissues in a label-free way. Here we employed multiple non-linear microscopy techniques, including CARS, TPF, and SHG to provide intrinsic optical contrast from various tissue components in both arterial wall and atherosclerotic plaques. CARS and TPF microscopy were used to respectively image lipid depositions within plaques and elastin in the arterial wall. Cholesterol deposition in the lumen and collagen in the arterial wall were selectively imaged by SHG microscopy and distinguished by forward-backward SHG ratio. Image pattern analysis allowed characterizing collagen organization in different tissue regions. Different values of fiber mean size, distribution and anisotropy are calculated for lumen and media prospectively allowing for automated classification of atherosclerotic lesions. The presented method represents a promising diagnostic tool for evaluating atherosclerotic tissue and has the potential to find a stable place in clinical setting as well as to be applied in vivo in the near future.

  3. The Benefits of Combination Therapy with Esomeprazole and Rebamipide in Symptom Improvement in Reflux Esophagitis: An International Multicenter Study.

    Science.gov (United States)

    Hong, Su Jin; Park, Soo-Heon; Moon, Jeong Seop; Shin, Woon Geon; Kim, Jae Gyu; Lee, Yong Chan; Lee, Dong Ho; Jang, Jae Young; Kim, Jae J; Lee, Hang-Lak; Lee, Sang Woo; Hwangbo, Young; Xu, Jianming; Wang, Bangmao; Xue, Zhanxiong; Liu, Fei; Yuan, Yaozong; Leelakusolvong, Somchai; Dy, Frederick

    2016-11-15

    To investigate the effects of esomeprazole and rebamipide combination therapy on symptomatic improvement in patients with reflux esophagitis. A total of 501 patients with reflux esophagitis were randomized into one of the following two treatment regimens: 40 mg esomeprazole plus 300 mg rebamipide daily (combination therapy group) or 40 mg esomeprazole daily (monotherapy group). We used a symptom questionnaire that evaluated heartburn, acid regurgitation, and four upper gastrointestinal symptoms. The primary efficacy end point was the mean decrease in the total symptom score. The mean decreases in the total symptom score at 4 weeks were estimated to be -18.1±13.8 in the combination therapy group and -15.1±11.9 in the monotherapy group (p=0.011). Changes in reflux symptoms from baseline after 4 weeks of treatment were -8.4±6.6 in the combination therapy group and -6.8±5.9 in the monotherapy group (p=0.009). Over a 4-week treatment course, esomeprazole and rebamipide combination therapy was more effective in decreasing the symptoms of reflux esophagitis than esomeprazole monotherapy.

  4. Linear Models

    CERN Document Server

    Searle, Shayle R

    2012-01-01

    This 1971 classic on linear models is once again available--as a Wiley Classics Library Edition. It features material that can be understood by any statistician who understands matrix algebra and basic statistical methods.

  5. Linear programming

    CERN Document Server

    Solow, Daniel

    2014-01-01

    This text covers the basic theory and computation for a first course in linear programming, including substantial material on mathematical proof techniques and sophisticated computation methods. Includes Appendix on using Excel. 1984 edition.

  6. Linear algebra

    CERN Document Server

    Berberian, Sterling K

    2014-01-01

    Introductory treatment covers basic theory of vector spaces and linear maps - dimension, determinants, eigenvalues, and eigenvectors - plus more advanced topics such as the study of canonical forms for matrices. 1992 edition.

  7. Linear algebra

    CERN Document Server

    Liesen, Jörg

    2015-01-01

    This self-contained textbook takes a matrix-oriented approach to linear algebra and presents a complete theory, including all details and proofs, culminating in the Jordan canonical form and its proof. Throughout the development, the applicability of the results is highlighted. Additionally, the book presents special topics from applied linear algebra including matrix functions, the singular value decomposition, the Kronecker product and linear matrix equations. The matrix-oriented approach to linear algebra leads to a better intuition and a deeper understanding of the abstract concepts, and therefore simplifies their use in real world applications. Some of these applications are presented in detailed examples. In several ‘MATLAB-Minutes’ students can comprehend the concepts and results using computational experiments. Necessary basics for the use of MATLAB are presented in a short introduction. Students can also actively work with the material and practice their mathematical skills in more than 300 exerc...

  8. Combining of small fragment screws and large fragment plates for open reduction and internal fixation of periprosthetic humeral fractures

    Directory of Open Access Journals (Sweden)

    Dominik Seybold

    2011-01-01

    Full Text Available Operative treatment of periprosthetic humeral fractures in elderly patients with osteoporotic bone requires a stable fixations technique. The combination of 3.5 cortical screws with washers in a 4.5 Arbeitsgemeinschaft fόr Osteosynthesefragen, Limited-contact dynamic compression plate or Locking plate, allows a stable periprosthetic fixation with the small 3.5 screws and 4.5 screws above and below the prosthesis, respectively. This combination is a cost-effective technique to treat periprosthetic humeral fractures.

  9. Combining external and internal mixing representation of atmospheric aerosol for optical properties calculations: focus on absorption properties over Europe and North America using AERONET observations and AQMEII simulations

    Science.gov (United States)

    Curci, Gabriele

    2017-04-01

    The calculation of optical properties from knowledge of the composition and abundance of atmospheric aerosol implies a certain number of assumptions. First and if not known or explicitly simulated, a size distribution must be assigned to each aerosol component (e.g. sulfate-like inorganic ions, organic and back carbon, soil dust, sea salt). Second, physical-chemical properties such as the shape, density, complex refractive index, and hygroscopic factors must be associated to each aerosol species. Third, a representation of how the aerosol species combine together must be made: among those, the most popular are the assumptions of external mixing, in which each particle is assumed to be formed of a single compound and the optical properties may be calculated separately for each species, or of internal core-shell arrangement, in which each particle consists of a water-insoluble core coated with a water-soluble shell and that requires more elaborate calculations for optical properties. Previous work found that the assumption on the mixing state (external or core-shell internal) is the one that introduces the highest uncertainty, quantified in about 30% uncertainty on the calculation of monthly mean aerosol optical depth (AOD) and single-scattering albedo (SSA). The external mixing assumption is generally more reasonable for freshly emitted aerosol, while the internal mixing case is associated with aged aerosol that had the time to form the coating around the core. Both approximations are thus regarded as valid, but in general a combination of the two mixing states may be expected in a given air mass. In this work, we test a simple empirical parameterization of the fraction of internally mixed particles (F_in) in a generic air mass. The F_in fraction is calculated in two alternative ways, one exploiting the NOz to NOx ratio (proxy of the photochemical aging), and the other using the relative abundance of black carbon with respect to other aerosol components (proxy of

  10. External fixation combined with limited internal fixation for Pilon fractures%外固定支架结合有限内固定治疗Pilon骨折

    Institute of Scientific and Technical Information of China (English)

    周淮; 徐晓军

    2011-01-01

    Objective To investigate the clinical effect of Pilon fractures treated with external fixation and limited internal fixation.Methods 24 cases of Pilon fractures of tibia were treated with external fixation combined limited internal fixation.Results 24 cases were followed up for 10 ~ 20 months.No bone nonumon or skin necrosis complication was found.According to Mazur ankle joint scoring system, the results were excellent in 14, good in 7 , and fair in 3.Conclusions External fixation combined with limited internal fixation can immohilize the sections of fracture and achieve excellent ankle joint function,so it is an effective surgical treatment of Pilon fractures.%目的 探讨外固定支架结合有限内固定治疗Pilon骨折的疗效.方法 采用外固定支架结合有限内固定治疗24例Pilon骨折.结果 24例均获得随访,时间10~20个月.无骨不连、皮肤坏死发生.踝关节功能Mazur评分:优14例,良7例,可3例.结论 外固定支架结合有限内固定可以获得术后骨折稳定,取得良好踝关节功能,是治疗Pilon骨折有效的手术方案.

  11. Combined treatment with GH and IGF-I: additive effect on cortical bone mass but not on linear bone growth in female rats.

    Science.gov (United States)

    Sundström, Katja; Cedervall, Therese; Ohlsson, Claes; Camacho-Hübner, Cecilia; Sävendahl, Lars

    2014-12-01

    The growth-promoting effect of combined therapy with GH and IGF-I in normal rats is not known. We therefore investigated the efficacy of treatment with recombinant human (rh)GH and/or rhIGF-I on longitudinal bone growth and bone mass in intact, prepubertal, female Sprague-Dawley rats. rhGH was injected twice daily sc (5 mg/kg·d) and rhIGF-I continuously infused sc (2.2 or 4.4 mg/kg·d) for 28 days. Longitudinal bone growth was monitored by weekly x-rays of tibiae and nose-anus length measurements, and tibial growth plate histomorphology was analyzed. Bone mass was evaluated by peripheral quantitative computed tomography. In addition, serum levels of IGF-I, rat GH, acid labile subunit, IGF binding protein-3, 150-kDa ternary complex formation, and markers of bone formation and degradation were measured. Monotherapy with rhGH was more effective than rhIGF-I (4.4 mg/kg·d) to increase tibia and nose-anus length, whereas combined therapy did not further increase tibia, or nose-anus, lengths or growth plate height. In contrast, combined rhGH and rhIGF-I (4.4 mg/kg·d) therapy had an additive stimulatory effect on cortical bone mass vs rhGH alone. Combined treatment with rhGH and rhIGF-I resulted in markedly higher serum IGF-I concentrations vs rhGH alone but did not compromise the endogenous secretion of GH. We conclude that rhIGF-I treatment augments cortical bone mass but does not further improve bone growth in rhGH-treated young, intact, female rats.

  12. Linear regression

    CERN Document Server

    Olive, David J

    2017-01-01

    This text covers both multiple linear regression and some experimental design models. The text uses the response plot to visualize the model and to detect outliers, does not assume that the error distribution has a known parametric distribution, develops prediction intervals that work when the error distribution is unknown, suggests bootstrap hypothesis tests that may be useful for inference after variable selection, and develops prediction regions and large sample theory for the multivariate linear regression model that has m response variables. A relationship between multivariate prediction regions and confidence regions provides a simple way to bootstrap confidence regions. These confidence regions often provide a practical method for testing hypotheses. There is also a chapter on generalized linear models and generalized additive models. There are many R functions to produce response and residual plots, to simulate prediction intervals and hypothesis tests, to detect outliers, and to choose response trans...

  13. Linear algebra

    CERN Document Server

    Sahai, Vivek

    2013-01-01

    Beginning with the basic concepts of vector spaces such as linear independence, basis and dimension, quotient space, linear transformation and duality with an exposition of the theory of linear operators on a finite dimensional vector space, this book includes the concept of eigenvalues and eigenvectors, diagonalization, triangulation and Jordan and rational canonical forms. Inner product spaces which cover finite dimensional spectral theory and an elementary theory of bilinear forms are also discussed. This new edition of the book incorporates the rich feedback of its readers. We have added new subject matter in the text to make the book more comprehensive. Many new examples have been discussed to illustrate the text. More exercises have been included. We have taken care to arrange the exercises in increasing order of difficulty. There is now a new section of hints for almost all exercises, except those which are straightforward, to enhance their importance for individual study and for classroom use.

  14. Linear algebra

    CERN Document Server

    Edwards, Harold M

    1995-01-01

    In his new undergraduate textbook, Harold M Edwards proposes a radically new and thoroughly algorithmic approach to linear algebra Originally inspired by the constructive philosophy of mathematics championed in the 19th century by Leopold Kronecker, the approach is well suited to students in the computer-dominated late 20th century Each proof is an algorithm described in English that can be translated into the computer language the class is using and put to work solving problems and generating new examples, making the study of linear algebra a truly interactive experience Designed for a one-semester course, this text adopts an algorithmic approach to linear algebra giving the student many examples to work through and copious exercises to test their skills and extend their knowledge of the subject Students at all levels will find much interactive instruction in this text while teachers will find stimulating examples and methods of approach to the subject

  15. Analysis of Entropy Generation of Combined Heat and Mass Transfer in Internal and External Flows with the Assumption of Local Thermodynamic Equilibrium

    Institute of Scientific and Technical Information of China (English)

    ShouguangYao

    1994-01-01

    In this paper,the control volume method is used to establish the general expression of entropy generation due to combined convective heat and mass transfer in internal and external fluid streams.The expression accounts for irreversibilities due to the presence of heat transfer across a finite temperature difference,mass transfer across a finite difference in the chemical potential of a species,and due to flow friction.Based on the assumption of local thermodynamic equilibrium,the generalized form of the Gibbs equation is used in this analysis.The results are applied to two fundamental problems of forced convection heat and mass transfer in internal and external flows.After minimizing the entropy generation,useful conclusions are derived that are typical of the second law viewpoint for the definition of the optimum operation conditions for the specified applications.which is a valuable criterion for optimum design of heat and fluid flow devices.

  16. Linear algebra

    CERN Document Server

    Allenby, Reg

    1995-01-01

    As the basis of equations (and therefore problem-solving), linear algebra is the most widely taught sub-division of pure mathematics. Dr Allenby has used his experience of teaching linear algebra to write a lively book on the subject that includes historical information about the founders of the subject as well as giving a basic introduction to the mathematics undergraduate. The whole text has been written in a connected way with ideas introduced as they occur naturally. As with the other books in the series, there are many worked examples.Solutions to the exercises are available onlin

  17. 射频预失真器与基带预失真算法结合对行波管功率放大器线性化改善的影响%Effect on the linearity improvement of TWTA by combining RF predistortion linearizer and digital predistortion algorithm

    Institute of Scientific and Technical Information of China (English)

    胡欣; 王刚; 王自成; 罗积润

    2012-01-01

    In order to keep Che adaptive digital predistortion algorithms valid,usually the output power level of the TWTA must be reduced,which corresponded a reduced efficiency of the TWTA. A predistortion technique was proposed by combining RF predistortion linearizer with adaptive digital predistortion algorithm,The gain and phase change of the TWTA with a RF predistortion linearizer circuit from small-signal input drive to saturated input drive were improved,respectively. Then the adaptive digital predistortion algorithm was used for the TWTA with the RF predistortion linearizer. The good linearity improvement can be reached with the less reduction for the output power level with this method.%为了保证自适应算法的效果,一般会将行波管输出功率进行一定回退,但是会降低行波管的工作效率.通过在行波管前端加入射频预失真器,在额定输入功率范围内,线性化后的行波管的非线性失真现象得到了一定程度改善,然后再进行基带自适应算法的实现.X波段行波管在输出功率回退较少的同时,达到较好的非线性失真改善效果.

  18. Combined linear response quantum mechanics and classical electrodynamics (QM/ED) method for the calculation of surface-enhanced Raman spectra.

    Science.gov (United States)

    Mullin, Jonathan; Schatz, George C

    2012-03-01

    A multiscale method is presented that allows for evaluation of plasmon-enhanced optical properties of nanoparticle/molecule complexes with no additional cost compared to standard electrodynamics (ED) and linear response quantum mechanics (QM) calculations for the particle and molecule, respectively, but with polarization and orientation effects automatically described. The approach first calculates the total field of the nanoparticle by ED using the finite difference time domain (FDTD) method. The field intensity in the frequency domain as a function of distance from the nanoparticle is calculated via a Fourier transform. The molecular optical properties are then calculated with QM in the frequency domain in the presence of the total field of the nanoparticle. Back-coupling due to dipolar reradiation effects is included in the single-molecule plane wave approximation. The effects of polarization and partial orientation averaging are considered. The QM/ED method is evaluated for the well-characterized test case of surface-enhanced Raman scattering (SERS) of pyridine bound to silver, as well as for the resonant Raman chromophore rhodamine 6G. The electromagnetic contribution to the enhancement factor is 10(4) for pyridine and 10(2) for rhodamine 6G. © 2012 American Chemical Society

  19. Design Development of a Combined Deployment and Pointing System for the International Space Station Neutron Star Interior Composition Explorer Telescope

    Science.gov (United States)

    Budinoff, Jason; Gendreau, Keith; Arzoumanian, Zaven; Baker, Charles; Berning, Robert; Colangelo, TOdd; Holzinger, John; Lewis, Jesse; Liu, Alice; Mitchell, Alissa; Monroe, Chuck; Pugh, Richard; Wiley, Roger

    2016-01-01

    This paper describes the design of a unique suite of mechanisms that make up the Deployment and Pointing System (DAPS) for the Neutron Star Interior Composition Explorer (NICER/SEXTANT) instrument, an X-Ray telescope, which will be mounted on the International Space Station (ISS). The DAPS system uses four stepper motor actuators to deploy the telescope box, latch it in the deployed position, and allow it to track sky targets. The DAPS gimbal architecture provides full-hemisphere coverage, and is fully re-stowable. The compact design of the mechanism allowed the majority of total instrument volume to be used for science. Override features allow DAPS to be stowed by ISS robotics.

  20. New, efficient and viable system for ethanol fuel utilization on combined electric/internal combustion engine vehicles

    Science.gov (United States)

    Sato, André G.; Silva, Gabriel C. D.; Paganin, Valdecir A.; Biancolli, Ana L. G.; Ticianelli, Edson A.

    2015-10-01

    Although ethanol can be directly employed as fuel on polymer-electrolyte fuel cells (PEMFC), its low oxidation kinetics in the anode and the crossover to the cathode lead to a substantial reduction of energy conversion efficiency. However, when fuel cell driven vehicles are considered, the system may include an on board steam reformer for converting ethanol into hydrogen, but the hydrogen produced contains carbon monoxide, which limits applications in PEMFCs. Here, we present a system consisting of an ethanol dehydrogenation catalytic reactor for producing hydrogen, which is supplied to a PEMFC to generate electricity for electric motors. A liquid by-product effluent from the reactor can be used as fuel for an integrated internal combustion engine, or catalytically recycled to extract more hydrogen molecules. Power densities comparable to those of a PEMFC operating with pure hydrogen are attained by using the hydrogen rich stream produced by the ethanol dehydrogenation reactor.

  1. Validation of an Internet-Based Long Version of the International Physical Activity Questionnaire in Danish Adults Using Combined Accelerometry and Heart Rate Monitoring

    DEFF Research Database (Denmark)

    Hansen, Andreas Wolff; Dahl-Petersen, Inger; Helge, Jørn Wulff;

    2014-01-01

    BACKGROUND: The International Physical Activity Questionnaire (IPAQ) is commonly used in surveys but reliability and validity has not been established in the Danish population. METHODS: Among participants in the Danish Health Examination survey 2007-2008, 142 healthy participants (45% men) wore...... a unit that combined accelerometry and heart rate monitoring (Acc+HR) for 7 consecutive days and then completed the IPAQ. Background data were obtained from the survey. Physical activity energy expenditure (PAEE) and time in moderate, vigorous and sedentary intensity level were derived from the IPAQ...

  2. Internal Model Control Design for First-order Linear Time-delay System%一阶线性时滞系统的内模控制设计

    Institute of Scientific and Technical Information of China (English)

    罗霄华

    2011-01-01

    内模控制是近年来发展起来的一种新型控制方法,分析它的原理对于工程应用和理论研究具有重要的意义。从IMC结构分析入手揭示了内模控制的本质,证明了该系统可实现对阶跃信号的无差跟踪及在阶跃信号扰动下可实现无差控制;介绍了时滞线性系统内模控制器和内模滤波器的设计方法。并基于MATLAB仿真研究表明,线性时滞过程的内模控制具有较好的鲁棒性,有一定的应用价值。%Internal model control is a new developing control method in recent years, its principle analysis is very important in engineering application and theoretical research. From the structure of IMC, the article reveals the essence of internal model control, and then it proves that the system can not only achieve the no difference tracking for the step signal, also realizes the no difference control with the disturbance of step signal. This article introduces the internal model controller for the linear time-delay system and the method of IMC filter designing. Based on the simulation with Matlab, it shows the great robustness for the internal model control in the linear time-delay process, and has great value on application.

  3. A combined EPR and MD simulation study of a nitroxyl spin label with restricted internal mobility sensitive to protein dynamics

    Science.gov (United States)

    Oganesyan, Vasily S.; Chami, Fatima; White, Gaye F.; Thomson, Andrew J.

    2017-01-01

    EPR studies combined with fully atomistic Molecular Dynamics (MD) simulations and an MD-EPR simulation method provide evidence for intrinsic low rotameric mobility of a nitroxyl spin label, Rn, compared to the more widely employed label MTSL (R1). Both experimental and modelling results using two structurally different sites of attachment to Myoglobin show that the EPR spectra of Rn are more sensitive to the local protein environment than that of MTSL. This study reveals the potential of using the Rn spin label as a reporter of protein motions.

  4. Simulation of bending stress variation in long buried thick-walled pipes under the earth’s movement using combined linear dynamics and beam theories

    Directory of Open Access Journals (Sweden)

    Salau Tajudeen A.O.

    2014-01-01

    Full Text Available This study reported a simulation approach to the understanding of the interactions between a buried pipe and the soil system by computing the bending stress variation of harmonically-excited buried pipes. The established principles of linear dynamics theory and simple beam theory were utilised in the analysis of the problem of buried pipe bending stress accumulation and its dynamics. With regards to the parameters that influence the bending stress variations, the most important are the isolation factor, uniform external load, and the corresponding limiting conditions. The simulated mathematical expressions, containing static and dynamic parameters of the buried pipe and earth, were coded in Fortran programming language and applied in the simulation experiment. The results obtained showed that harmonically-excited buried thick-walled pipe became stable and effective when the ratio of the natural frequency of vibration to the forced frequency is greater than 2.0, whenever the damped factor is used as the control parameter for the maximum bending stress. The mirror image of the stress variation produces variation in the location of the maximum bending stress in quantitative terms. The acceptable pipe materials for the simulated cases must have yield strength in bending greater than or equal to 13.95 MPa. The results obtained in this work fill a gap in the literature and will be useful to pipeline engineers and designers, as well as to environmental scientists in initialising and controlling environmental issues and policy formulation concerning the influence of buried pipe on the soil and water in the environment.

  5. Combined study of Schwinger-boson mean-field theory and linearized tensor renormalization group on Heisenberg ferromagnetic mixed spin (S, σ chains

    Directory of Open Access Journals (Sweden)

    Xin Yan

    2015-07-01

    Full Text Available The Schwinger-boson mean-field theory (SBMFT and the linearized tensor renormalization group (LTRG methods are complementarily applied to explore the thermodynamics of the quantum ferromagnetic mixed spin (S, σ chains. It is found that the system has double excitations, i.e. a gapless and a gapped excitation; the low-lying spectrum can be approximated by ω k ∼ S σ 2 ( S + σ J k 2 with J the ferromagnetic coupling; and the gap between the two branches is estimated to be △ ∼ J. The Bose-Einstein condensation indicates a ferromagnetic ground state with magnetization m tot z = N ( S + σ . At low temperature, the spin correlation length is inversely proportional to temperature (T, the susceptibility behaviors as χ = a 1 ∗ 1 T 2 + a 2 ∗ 1 T , and the specific heat has the form of C = c 1 ∗ T − c 2 ∗ T + c 3 ∗ T 3 2 , with ai (i = 1, 2 and ci (i = 1, 2, 3 the temperature independent constants. The SBMFT results are shown to be in qualitatively agreement with those by the LTRG numerical calculations for S = 1 and σ = 1/2. A comparison of the LTRG results with the experimental data of the model material MnIINiII(NO24(en2(en = ethylenediamine, is made, in which the coupling parameters of the compound are obtained. This study provides useful information for deeply understanding the physical properties of quantum ferromagnetic mixed spin chain materials.

  6. A Combined Isotropic, Kinematic and Cross Hardening Model for Magnesium AZ31B-H24 under Non-linear Strain Loading Path

    Science.gov (United States)

    Jia, Yueqian; Bai, Yuanli

    2016-08-01

    A fully modularized framework was established to combine isotropic, kinematic, and cross hardening behaviors under non-monotonic loading conditions. Three sets of state variables were defined and applied to consider the effects of, a) loading history, b) twinning and de-twinning and c) different pre-strain. Experiments under two types of non-proportional loading conditions were conducted along different orientations, 1) uniaxial compression-tension reversal loading with different amounts of compressive strains, and 2) two-step uniaxial tension, known as cross-loading conditions, with different pre-strains. No apparent cross-hardening effect was observed for this material. The calibrated new hardening model, with an anisotropic CPB06ex2 yield criterion and an eMMC anisotropic fracture model, has been implemented into Abaqus/ Explicit as a user material subroutine (VUMAT). Good correlation was observed between experimental and simulation results.

  7. Osteosynthesis of ununited femoral neck fracture by internal fixation combined with iliac crest bone chips and muscle pedicle bone grafting

    Directory of Open Access Journals (Sweden)

    D D Baksi

    2016-01-01

    Full Text Available Background: Ununited femoral neck fracture is seen commonly in developing countries due to delayed presentation or failure of primary internal fixation. Such fractures, commonly present with partial or total absorption of femoral neck, osteonecrosis of femoral head in 8-30% cases with upward migration of trochanter posing problem for osteosynthesis, especially in younger individuals. Several techniques for treatment of such conditions are described like osteotomies or nonvascularied cortical or cancellous bone grafting provided varying degrees of success in terms of fracture union but unsatisfactory long term results occurred due to varying incidence of avascular necrosis (AVN of femoral head. Moreover, in presence of AVN of femoral head neither free fibular graft nor cancellous bone graft is satisfactory. The vascularied bone grafting by deep circumflex iliac artery based on iliac crest bone grafting, free vascularied fibular grafting and muscle pedicle periosteal grafting showed high incidence of success rate. Osteosynthesis is the preferred treatment of choice in ununited femoral neck fracture in younger individuals. Materials and Methods: Of the 293 patients operated during the period from June 1977 to June 2009, 42 were lost to followup. Seven patients with gluteus medius muscle pedicle bone grafting (MPBG were excluded. Thus, out of 244 patients, 208 (85.3% untreated nonunion and 36 (14.7% following failure of primary internal fixation were available for studies. Time interval between the date of injury and operation in untreated nonunion cases was mean 6.5 months and in failed internal fixation cases was mean 11.2 months. Ages of the patients varied from 16 to 55 years. Seventy patients had partial and 174 had subtotal absorption of the femoral neck. Evidence of avascular necrosis (AVN femoral head was found histologically in 135 (54.3% and radiologically in 48 (19.7% patients. The patients were operated by open reduction of fracture

  8. Linear programming

    CERN Document Server

    Karloff, Howard

    1991-01-01

    To this reviewer’s knowledge, this is the first book accessible to the upper division undergraduate or beginning graduate student that surveys linear programming from the Simplex Method…via the Ellipsoid algorithm to Karmarkar’s algorithm. Moreover, its point of view is algorithmic and thus it provides both a history and a case history of work in complexity theory. The presentation is admirable; Karloff's style is informal (even humorous at times) without sacrificing anything necessary for understanding. Diagrams (including horizontal brackets that group terms) aid in providing clarity. The end-of-chapter notes are helpful...Recommended highly for acquisition, since it is not only a textbook, but can also be used for independent reading and study. —Choice Reviews The reader will be well served by reading the monograph from cover to cover. The author succeeds in providing a concise, readable, understandable introduction to modern linear programming. —Mathematics of Computing This is a textbook intend...

  9. Combination of TRAIL with bortezomib shifted apoptotic signaling from DR4 to DR5 death receptor by selective internalization and degradation of DR4.

    Directory of Open Access Journals (Sweden)

    Maxim L Bychkov

    Full Text Available TRAIL (tumor necrosis factor-related apoptosis-inducing ligand mediates apoptosis in cancer cells through death receptors DR4 and DR5 preferring often one receptor over another in the cells expressing both receptors. Receptor selective mutant variants of TRAIL and agonistic antibodies against DR4 and DR5 are highly promising anticancer agents. Here using DR5 specific mutant variant of TRAIL--DR5-B we have demonstrated for the first time that the sensitivity of cancer cells can be shifted from one TRAIL death receptor to another during co-treatment with anticancer drugs. First we have studied the contribution of DR4 and DR5 in HCT116 p53+/+ and HCT116 p53-/- cells and demonstrated that in HCT116 p53+/+ cells the both death receptors are involved in TRAIL-induced cell death while in HCT116 p53-/- cells prevailed DR4 signaling. The expression of death (DR4 and DR5 as well as decoy (DcR1 and DcR2 receptors was upregulated in the both cell lines either by TRAIL or by bortezomib. However, combined treatment of cells with two drugs induced strong time-dependent and p53-independent internalization and further lysosomal degradation of DR4 receptor. Interestingly DR5-B variant of TRAIL which do not bind with DR4 receptor also induced elimination of DR4 from cell surface in combination with bortezomib indicating the ligand-independent mechanism of the receptor internalization. Eliminatory internalization of DR4 resulted in activation of DR5 receptor thus DR4-dependent HCT116 p53-/- cells became highly sensitive to DR5-B in time-dependent manner. Internalization and degradation of DR4 receptor depended on activation of caspases as well as of lysosomal activity as it was completely inhibited by Z-VAD-FMK, E-64 and Baf-A1. In light of our findings, it is important to explore carefully which of the death receptors is active, when sensitizing drugs are combined with agonistic antibodies to the death receptors or receptor selective variants of TRAIL to enhance

  10. Combination of TRAIL with bortezomib shifted apoptotic signaling from DR4 to DR5 death receptor by selective internalization and degradation of DR4.

    Science.gov (United States)

    Bychkov, Maxim L; Gasparian, Marine E; Dolgikh, Dmitry A; Kirpichnikov, Mikhail P

    2014-01-01

    TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) mediates apoptosis in cancer cells through death receptors DR4 and DR5 preferring often one receptor over another in the cells expressing both receptors. Receptor selective mutant variants of TRAIL and agonistic antibodies against DR4 and DR5 are highly promising anticancer agents. Here using DR5 specific mutant variant of TRAIL--DR5-B we have demonstrated for the first time that the sensitivity of cancer cells can be shifted from one TRAIL death receptor to another during co-treatment with anticancer drugs. First we have studied the contribution of DR4 and DR5 in HCT116 p53+/+ and HCT116 p53-/- cells and demonstrated that in HCT116 p53+/+ cells the both death receptors are involved in TRAIL-induced cell death while in HCT116 p53-/- cells prevailed DR4 signaling. The expression of death (DR4 and DR5) as well as decoy (DcR1 and DcR2) receptors was upregulated in the both cell lines either by TRAIL or by bortezomib. However, combined treatment of cells with two drugs induced strong time-dependent and p53-independent internalization and further lysosomal degradation of DR4 receptor. Interestingly DR5-B variant of TRAIL which do not bind with DR4 receptor also induced elimination of DR4 from cell surface in combination with bortezomib indicating the ligand-independent mechanism of the receptor internalization. Eliminatory internalization of DR4 resulted in activation of DR5 receptor thus DR4-dependent HCT116 p53-/- cells became highly sensitive to DR5-B in time-dependent manner. Internalization and degradation of DR4 receptor depended on activation of caspases as well as of lysosomal activity as it was completely inhibited by Z-VAD-FMK, E-64 and Baf-A1. In light of our findings, it is important to explore carefully which of the death receptors is active, when sensitizing drugs are combined with agonistic antibodies to the death receptors or receptor selective variants of TRAIL to enhance cancer treatment

  11. Pars plana vitrectomy combined with internal limiting membrane peeling for recurrent macular edema due to branch retinal vein occlusion after antivascular endothelial growth factor treatments

    Directory of Open Access Journals (Sweden)

    Shirakata Y

    2016-02-01

    Full Text Available Yukari Shirakata,1 Kouki Fukuda,1 Tomoyoshi Fujita,1 Yuki Nakano,1 Hiroyuki Nomoto,2 Hidetaka Yamaji,3 Fumio Shiraga,4 Akitaka Tsujikawa1 1Department of Ophthalmology, Faculty of Medicine, Kagawa University, Miki-cho, 2Nomoto Eye Clinic, Himeji, 3Department of Ophthalmology, Shirai Eye Hospital, Mitoyo, 4Department of Ophthalmology, Okayama University, Okayama, Japan Purpose: To evaluate the anatomic and functional outcomes of pars plana vitrectomy combined with internal limiting membrane peeling for recurrent macular edema (ME due to branch retinal vein occlusion (BRVO after intravitreal injections of antivascular endothelial growth factor (anti-VEGF agents. Methods: Twenty-four eyes of 24 patients with treatment-naive ME from BRVO were treated with intravitreal injections of anti-VEGF agents. Recurred ME was treated with pars plana vitrectomy combined with internal limiting membrane peeling. Results: After the surgery, ME was significantly reduced at 1 month (P=0.031 and the reduction increased with time (P=0.007 at the final visit. With the reduction in ME, treated eyes showed a slow improvement in visual acuity (VA. At the final visit, improvement in VA was statistically significant compared with baseline (P=0.048. The initial presence of cystoid spaces, serous retinal detachment, or subretinal hemorrhage under the fovea, as well as retinal perfusion status, showed no association with VA improvement. However, the presence of epiretinal membrane showed a significant association with the visual recovery. Although eyes without epiretinal membrane showed visual improvement (-0.10±0.32 in logarithm of the minimum angle of resolution [logMAR], eyes with epiretinal membrane showed greater visual improvement (-0.38±0.12 in logMAR, P=0.012. Conclusion: For recurrent ME due to BRVO after anti-VEGF treatment, particularly when accompanied by epiretinal membrane, pars plana vitrectomy combined with internal limiting membrane peeling might be a

  12. Origin of the hemoglobin S gene in a northern Brazilian population: the combined effects of slave trade and internal migrations

    Directory of Open Access Journals (Sweden)

    Gabriella Pante-de-Sousa

    1998-12-01

    Full Text Available We analyzed DNA polymorphisms in the b-globin gene cluster of 30 sickle cell anemia patients from Belém, the capital city of the State of Pará, in order to investigate the origin of the bS mutation. Sixty-seven percent of the bS chromosomes were Bantu type, 30% were Benin type, and 3% were Senegal type. The origin of the bS mutation in this population, estimated on the basis of bS-linked haplotypes, contradicts the historical records of direct slave trade from Africa to the northern region of Brazil. Historical records indicate a lower percentage of people from Benin. These discrepancies are probably due to domestic slave trade and later internal migrations, mainly from northeastern to northern regions. Haplotype distribution in Belém did not differ significantly from that observed in other Brazilian regions, although historical records indicate that most slaves from Atlantic West Africa, where the Senegal haplotype is prevalent, were destined for the northern region, whereas the northeast (Bahia, Pernambuco and Maranhão was heavily supplied with slaves from Central West Africa, where the Benin haplotype predominates.Com o objetivo de investigar a origem da mutação bS na população da região norte do Brasil, foram analisados polimorfismos de DNA no complexo de genes b da hemoglobina em 30 pacientes com anemia falciforme na população de Belém, a capital do Estado do Pará. Sessenta e sete por cento dos cromossomos bS analisados apresentaram o haplótipo Bantu, 30% o haplótipo Benin e 3% o haplótipo Senegal. A origem da mutação bS na população de Belém, estimada de acordo com a distribuição de haplótipos, não está de acordo com a esperada com base em dados históricos sobre o tráfico de escravos para a região norte, os quais indicam uma reduzida contribuição de escravos da região do Benin. Essas diferenças podem ser atribuídas ao tráfico interno de escravos, bem como ao posterior fluxo de populações imigrantes

  13. Linear systems

    CERN Document Server

    Bourlès, Henri

    2013-01-01

    Linear systems have all the necessary elements (modeling, identification, analysis and control), from an educational point of view, to help us understand the discipline of automation and apply it efficiently. This book is progressive and organized in such a way that different levels of readership are possible. It is addressed both to beginners and those with a good understanding of automation wishing to enhance their knowledge on the subject. The theory is rigorously developed and illustrated by numerous examples which can be reproduced with the help of appropriate computation software. 60 exe

  14. 智能天线内置一体化合路校准网络%An Internal Integration of Combiner and Calibrating Network Used for Smart Antennas

    Institute of Scientific and Technical Information of China (English)

    张晓; 薛锋章

    2014-01-01

    为解决传统合路器体积重量与损耗不能兼顾的问题,提出了一种用于智能天线的内置一体化合路校准网络,采用微带结构,由带阻合路器和校准网络组成。实测结果表明,合路校准网络的通带插损小于0.7dB、通带回波损耗小于-15dB、阻带抑制大于30dB。该一体化合路校准网络具有集成度高、体积小、重量轻、工艺简单等特点,有利于减小智能天线的体积及重量。%In order to solve the problem that traditional combiners can't take volume, weight and loss into account simultaneously, an internal integration of combiner and calibrating network used for smart antennas is proposed. It adopts microstrip structure and consists of a bandstop combiner and a calibrating network. Measurement results show that its passband insertion loss is less than 0.7dB, while passband return loss is less than-15dB and stopband restrain is more than 30dB. The integration of combiner and calibrating network proposed has the advantages of high integration, small volume, light weight and simple crafts, which is good for reducing the antenna's volume and weight.

  15. Use of combined maximum and minimum intensity projections to determine internal target volume in 4-dimensional CT scans for hepatic malignancies

    Directory of Open Access Journals (Sweden)

    Liu Jin

    2012-01-01

    Full Text Available Abstract Background To evaluate the accuracy of the combined maximum and minimum intensity projection-based internal target volume (ITV delineation in 4-dimensional (4D CT scans for liver malignancies. Methods 4D CT with synchronized IV contrast data were acquired from 15 liver cancer patients (4 hepatocellular carcinomas; 11 hepatic metastases. We used five approaches to determine ITVs: (1. ITVAllPhases: contouring gross tumor volume (GTV on each of 10 respiratory phases of 4D CT data set and combining these GTVs; (2. ITV2Phase: contouring GTV on CT of the peak inhale phase (0% phase and the peak exhale phase (50% and then combining the two; (3. ITVMIP: contouring GTV on MIP with modifications based on physician's visual verification of contours in each respiratory phase; (4. ITVMinIP: contouring GTV on MinIP with modification by physician; (5. ITV2M: combining ITVMIP and ITVMinIP. ITVAllPhases was taken as the reference ITV, and the metrics used for comparison were: matching index (MI, under- and over-estimated volume (Vunder and Vover. Results 4D CT images were successfully acquired from 15 patients and tumor margins were clearly discernable in all patients. There were 9 cases of low density and 6, mixed on CT images. After comparisons of metrics, the tool of ITV2M was the most appropriate to contour ITV for liver malignancies with the highest MI of 0.93 ± 0.04 and the lowest proportion of Vunder (0.07 ± 0.04. Moreover, tumor volume, target motion three-dimensionally and ratio of tumor vertical diameter over tumor motion magnitude in cranio-caudal direction did not significantly influence the values of MI and proportion of Vunder. Conclusion The tool of ITV2M is recommended as a reliable method for generating ITVs from 4D CT data sets in liver cancer.

  16. Output feedback suboptimal disturbance rejection for linear systems : internal - model principle method%线性系统的输出反馈次优扰动抑制:内模原理方法

    Institute of Scientific and Technical Information of China (English)

    雷靖

    2012-01-01

    The paper considered the output feedback disturbance rejection problem based on internal - model principle for linear systems. According to the disturbance dynamics, the internal model was constructed. The optimal disturbance rejection problem was transformed into an equivalent optimal regulation problem for the augmented system. Then, a reduced - order state observer was constructed to reconstruct the unmeasurable state variables from the output feedback. The suboptimal control law was derived from series matrix differential equations or matrix equations, in which the disturbance was eliminated by the internal -model compensator. Finally, a simplified offshore platform system was applied for simulation example. Comparing with the feedforward and feedback optimal disturbance rejection control law, the designed controller was validated to be able to reject disturbance without steadystate error.%运用内模原理研究线性系统的输出反馈扰动抑制问题.首先根据扰动的动态特性构造内模系统,将最优扰动抑制问题转化为等价的最优调节问题.然后通过构造降维状态观测器重构输出反馈中测量不到的部分状态变量;通过求解一组矩阵微分方程或矩阵方程得到次优控制律,利用控制律中的内模补偿项与外部扰动进行对消.最后采用海洋平台简化模型作仿真示例,将所设计的扰动抑制控制器与前馈反馈最优扰动抑制控制器作比较,证明所设计的控制器能够实现无静差的扰动抑制.

  17. Sphincter-preserving RO total mesorectal excision with resection of internal genitalia combined with pre- or postoperative chemoradiation for T4 rectal cancer in females

    Institute of Scientific and Technical Information of China (English)

    Bartlomiej Szynglarewicz; Rafal Matkowski; Piotr Kasprzak; Daniel Sydor; Jozef Forgacz; Marek Pudelko; Jan Kornafel

    2007-01-01

    AIM: To evaluate the impact of chemoradiation administered pre- or postoperatively on prognosis in females following RO extended resection with sphincterpreserving total mesorectal excision (TME) for locally advanced rectal cancer and to assess the association between chemoradiation and intra- and postoperative variables.METHODS: Twenty-one females were treated for locally advanced but preoperatively assessed as primarily resectable rectal cancer involving reproductive organs. Anterior resection with TME and excision of internal genitalia was combined with neo- or adjuvant chemoradiation. Two-year disease-free survival analysis was performed with the Kaplan-Meier method and logrank test. The association between chemoradiation and other variables was evaluated with the Fisher's exact test and Mann-Whitney test.RESULTS: Survival rate decreased in anaemic females (51.5% vs 57.4%), in patients older than 60 years (41.8% vs 66.7%) with poorly differentiated cancers (50.0% vs 55.6%) and tumors located ≤ 7 cm from the anal verge (42.9% vs 68.1%) but with the lack of importance. Patients with negative lymph nodes and women chemoradiated preoperatively had significantly favourable prognosis (85.7% vs 35.7%; P= 0.03 and 80.0% vs 27.3%; P = 0.01, respectively). Preoperative chemoradiation compared to adjuvant radiochemotherapy was not significantly associated with the duration of surgery, incidence of intraoperative bowel perforation and blood loss ≥ 1 L, rate of postoperative bladder and anorectal dysfunction, and minimal distal resection margin. It significantly influenced minimal radial margin (mean 4.2 mm vs 1.1 mm; P < 0.01).CONCLUSION: Despite involving internal genitalia, long-term disease-free survival and sphincter preservation may be achieved with combined-modality therapy for females with T4 locally advanced rectal carcinoma. Neoadjuvant chemoradiation does not compromise functional results and may significantly improve oncological outcomes probably due to

  18. Linear recursive distributed representations.

    Science.gov (United States)

    Voegtlin, Thomas; Dominey, Peter F

    2005-09-01

    Connectionist networks have been criticized for their inability to represent complex structures with systematicity. That is, while they can be trained to represent and manipulate complex objects made of several constituents, they generally fail to generalize to novel combinations of the same constituents. This paper presents a modification of Pollack's Recursive Auto-Associative Memory (RAAM), that addresses this criticism. The network uses linear units and is trained with Oja's rule, in which it generalizes PCA to tree-structured data. Learned representations may be linearly combined, in order to represent new complex structures. This results in unprecedented generalization capabilities. Capacity is orders of magnitude higher than that of a RAAM trained with back-propagation. Moreover, regularities of the training set are preserved in the new formed objects. The formation of new structures displays developmental effects similar to those observed in children when learning to generalize about the argument structure of verbs.

  19. International linear collider simulations using BDSIM

    Indian Academy of Sciences (India)

    J Carter; I Agapov; G A Blair; O Dadoun

    2007-12-01

    Power loss simulations for the 2, 14, and 20 mrad extraction line designs using the BDSIM toolkit are presented. A preliminary study on the backgrounds from the beam losses along the extraction line in the case of 20 mrad with high luminosity parameters is also given.

  20. The International Linear Collider Progress Report 2015

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, Akira [SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2015-07-15

    The ILC technical design is now being adapted to the preferred candidate site. Changes in layout are being managed by a rigorous change-control procedure. Series production of cavities for the European XFEL has shown that cavities can be mass-produced in industry with a performance well above XFEL requirements and close to that needed for the ILC. A number of technical developments are under way with a view to further reducing the ILC cost. This work must continue through the preparatory stage for ILC construction once resources become available. A summary of the design updates and of the further preparatory work needed is summarized in tabular form in the Appendix.

  1. The International Linear Collider beam dumps

    OpenAIRE

    Appleby, R.; Keller, L; Markiewicz, T.; Seryi, A.; Sugahara, R.; Walz, D.

    2006-01-01

    The ILC beam dumps are a key part of the accelerator design. At Snowmass 2005, the current status of the beam dump designs were reviewed, and the options for the overall dump layout considered. This paper describes the available dump options for the baseline and the alternatives and considers issues for the dumps that require resolution.

  2. Combination of icotinib, surgery, and internal-radiotherapy of a patient with lung cancer severely metastasized to the vertebrae bones with EGFR mutation: a case report

    Directory of Open Access Journals (Sweden)

    Qu LL

    2015-06-01

    Full Text Available Li-Li Qu, Hai-Feng Qin, Hong-Jun Gao, Xiao-Qing Liu Department of Lung Cancer, Affiliated Hospital of Academy of Military Medical Science, Beijing, People’s Republic of China Abstract: A 48-year-old Chinese female was referred to us regarding EGFR-mutated advanced non-small cell lung cancer, and metastasis to left scapula and vertebrae bones which caused pathological fracture at T8 and T10 thoracic vertebrae. An aggressive combined therapy with icotinib, vertebrae operation, and radioactive particle implantation and immunotherapy was proposed to prevent paraplegia, relieve pain, and control the overall and local tumor lesions. No postoperative symptoms were seen after surgery, and the pain was significantly relieved. Icotinib merited a 31-month partial response with grade 1 diarrhea as its drug-related adverse event. High dose of icotinib was administered after pelvis lesion progression for 3 months with good tolerance. Combination therapy of icotinib, surgery, and internal radiation for metastases of the vertebrae bones from non-small cell lung cancer seems to be a very promising technique both for sufficient pain relief and for local control of the tumor, vertebrae operation can be an encouraging option for patients with EFGR positive mutation and good prognosis indicator. Keywords: lung cancer, spinal metastasis, pathological fracture, spinal canal stenosis, icotinib

  3. FEM simulation of the dynamical pressure and temperature load in target materials of the positron source for the International Linear Collider (ILC); FEM-Simulation der dynamischen Druck- und Temperaturbelastung in Targetmaterialien der Positronenquelle fuer den International Linear Collider (ILC) unter der Einwirkung von kurzen hochenergetischen Teilchenstrahlpulsen

    Energy Technology Data Exchange (ETDEWEB)

    Dietrich, Felix

    2014-12-15

    Future linear elektron-positron colliders at high energies require a huge amount of positrons during operation time. Positrons are produced by pulsed high-energy electron beams which pass a target. The deposited energy along their path is increasing the temperature immediately and causes stress in the target material. Using the commercial software package ANSYS the development and evolution of potential stress waves in a W-26% is simulated to obtain the dynamic behavior of the material. The load due to the electron beam causes stress waves which still exist 30μs after the cut off. The maximum stress value of the von Mises stress is 392 MPa. That is well below the limit of elasticity. However, cyclic load up to 643 MPa is obtained exceeding the fatigue limit. To provide an optimum design for a positron target these results have to be taken into account.

  4. Polarized Electrons for Linear Colliders

    CERN Document Server

    Clendenin, J E; Garwin, E L; Kirby, R E; Luh, D A; Maruyama, T; Prescott, C Y; Sheppard, J C; Turner, J; Prepost, R

    2005-01-01

    Future electron-positron linear colliders require a highly polarized electron beam with a pulse structure that depends primarily on whether the acceleration utilizes warm or superconducting rf structures. The International Linear Collider (ILC) will use cold structures for the main linac. It is shown that a dc-biased polarized photoelectron source such as successfully used for the SLC can meet the charge requirements for the ILC micropulse with a polarization approaching 90%.

  5. Clinical efficacy and safety of limited internal fixation combined with external fixation for Pilon fracture: A systematic review and meta-analysis.

    Science.gov (United States)

    Zhang, Shao-Bo; Zhang, Yi-Bao; Wang, Sheng-Hong; Zhang, Hua; Liu, Peng; Zhang, Wei; Ma, Jing-Lin; Wang, Jing

    2017-04-01

    To compare the clinical efficacy and complications of limited internal fixation combined with external fixation (LIFEF) and open reduction and internal fixation (ORIF) in the treatment of Pilon fracture. We searched databases including Pubmed, Embase, Web of science, Cochrane Library and China Biology Medicine disc for the studies comparing clinical efficacy and complications of LIFEF and ORIF in the treatment of Pilon fracture. The clinical efficacy was evaluated by the rate of nonunion, malunion/delayed union and the excellent/good rate assessed by Mazur ankle score. The complications including infections and arthritis symptoms after surgery were also investigated. Nine trials including 498 pilon fractures of 494 patients were identified. The meta-analysis found no significant differences in nonunion rate (RR = 1.60, 95% CI: 0.66 to 3.86, p = 0.30), and the excellent/good rate (RR = 0.95, 95% CI: 0.86 to 1.04, p = 0.28) between LIFEF group and ORIF group. For assessment of infections, there were significant differences in the rate of deep infection (RR = 2.18, 95% CI: 1.34 to 3.55, p = 0.002), and the rate of arthritis (RR = 1.26, 95% CI: 1.03 to 1.53, p = 0.02) between LIFEF group and ORIF group. LIFEF has similar effect as ORIF in the treatment of pilon fractures, however, LIFEF group has significantly higher risk of complications than ORIF group does. So LIFEF is not recommended in the treatment of pilon fracture. Copyright © 2017 Daping Hospital and the Research Institute of Surgery of the Third Military Medical University. Production and hosting by Elsevier B.V. All rights reserved.

  6. LINEAR SYSTEMS AND LINEAR INTERPOLATION I

    Institute of Scientific and Technical Information of China (English)

    丁立峰

    2001-01-01

    he linear interpolation of linear system on a family of linear systems is introduced and discussed. Some results and examples on singly generated systems on a finite dimensional vector space are given.

  7. Feature-Weighted Linear Stacking

    CERN Document Server

    Sill, Joseph; Mackey, Lester; Lin, David

    2009-01-01

    Ensemble methods, such as stacking, are designed to boost predictive accuracy by blending the predictions of multiple machine learning models. Recent work has shown that the use of meta-features, additional inputs describing each example in a dataset, can boost the performance of ensemble methods, but the greatest reported gains have come from nonlinear procedures requiring significant tuning and training time. Here, we present a linear technique, Feature-Weighted Linear Stacking (FWLS), that incorporates meta-features for improved accuracy while retaining the well-known virtues of linear regression regarding speed, stability, and interpretability. FWLS combines model predictions linearly using coefficients that are themselves linear functions of meta-features. This technique was a key facet of the solution of the second place team in the recently concluded Netflix Prize competition. Significant increases in accuracy over standard linear stacking is demonstrated on the Netflix Prize collaborative filtering da...

  8. Effect of internal carotid artery reperfusion in combination with Tenecteplase on clinical scores and hemorrhage in a rabbit embolic stroke model.

    Science.gov (United States)

    Lapchak, Paul A

    2009-10-19

    In the present study, we used a modification of the rabbit small clot embolic stroke model (RSCEM), a multiple infarct ischemia model to achieve reperfusion (REP) through the internal carotid artery (ICA) following small clot embolization. We determined if increasing regional cortical blood flow (RCBF) following an embolic stroke is beneficial to neurological outcome. We compared this to cerebral reperfusion induced by the administration of the thrombolytic Tenecteplase (TNK, 1.5 mg/kg, IV bolus) in the presence or absence of REP. In this study, we also measured the incidence of ICH following REP and thrombolytic treatment. Following embolization, RCBF was reduced to 48-55% of baseline. When REP was induced by removal of a CCA ligature, RCBF initially increased to 185% of baseline. REP (P(50)=1.18+/-0.43 mg) had no effect on embolization-induced behavior measured 24 h following embolization compared to control (P(50)=1.01+/-0.48 mg). However, TNK treatment (2-hours post-embolization) in the absence or presence of REP (initiated 2 h following embolization) significantly (p0.05) group compared to either the control group (5.5%) or TNK group (10%). This study show that reperfusion of ICA can increase RCBF following embolization, but this is not associated with improved neurological outcome measured using quantal analysis. However, TNK administration significantly increased behavioral outcome when given 2 h following embolization; an increase that is not affected by combining TNK with REP.

  9. A CLINICAL STUDY ON FUNCTIONAL OUTCOME AFTER COMBINED ARTHROSCOPIC AND FLUOROSCOPIC ASSISTED REDUCTION AND INTERNAL FIXATION OF CLOSED TIBIAL PLATEAU FRACTURES IN ADULTS

    Directory of Open Access Journals (Sweden)

    Bhavani Prasad

    2015-06-01

    Full Text Available BACKGROUND AND INTRODUCTION: Management of tibial plateau fractures had witnessed tremendous improvement in surgical techniques over the past decades. Conservative treatment of these fractures results in consistently poor results. The present literature supports that absolute anatomi cal reduction and stable fixation of peri articular fractures followed by early post - operative rehabilitation is crucial for good results. And if this is achieved by minimal damage to soft tissue the results are much better. In this study it is achieved by arthroscopy and fluoroscopy. MATERIALS AND METHODS: We have conducted a prospective study between September 2009 to august 2013 including 9 patients with tibial plateau fractures treated with combined arthroscopic and fluoroscopic reduction and internal f ixation with or without bone grafting. And then the radiographic and functional evaluation done. RESULTS: According to Hohl’s clinical and radiographic scoring systems 4 patients were assessed excellent, 3 good, 2 fair. According to Rasmussen’s clinical sc oring system 4 patients excellent, 3 good and 2 fair results. CONCLUSION: The use of arthroscopy and fluoroscopy in the management of tibial plateau fractures results in good outcome. It also helped to simultaneously treat the meniscal injuries. But its use is mainly limited to Shatzkar type1, 2, 3, 4

  10. Evaluation of Medicinal Categorization of Atractylodes japonica Koidz. by Using Internal Transcribed Spacer Sequencing Analysis and HPLC Fingerprinting Combined with Statistical Tools.

    Science.gov (United States)

    Kim, Jung-Hoon; Doh, Eui-Jeong; Lee, Guemsan

    2016-01-01

    Atractylodes rhizomes have been used as the herbal medicine "Changchul" or "Baekchul," according to their clinical purpose, in Korea, China, and Japan. Among the Atractylodes species, the medicinal use of Atractylodes japonica has been controversial, as it is categorized as both Changchul and Baekchul in those countries, and, moreover, parts of the rhizome have been differently used, depending on age of the plant, in Korea. Chromatographic fingerprinting by using HPLC combined with chemometric analyses and internal transcribed spacer (ITS) sequencing analysis were conducted to classify and identify 34 crude drugs derived from Atractylodes rhizomes. The identification of the samples, authenticated by their morphological features as A. japonica Koidz. (Changchul and Baekchul), A. chinensis Koidz., and A. macrocephala Koidz., was confirmed as A. japonica, A. chinensis, and A. macrocephala by ITS sequencing. The results from chemometric analyses showed that the chemical components of the crude drugs from A. japonica were significantly different from those from A. macrocephala but were similar to those from A. chinensis. The analyses also suggested that the categorization by age of A. japonica as Changchul or Baekchul is not recommended. The results indicate that A. japonica should be categorized as "Changchul" and should not be further categorized by age.

  11. The Making of discussion groups in a combined process of internal evaluation of safety culture; La realizacion de grupos de discuion en un proceso combinado de evaluacion interna de cultura de seguridad

    Energy Technology Data Exchange (ETDEWEB)

    German, S.; Buedo, J. L.; La Salabarnada, E.; Navajas, J.; Silla, I.

    2012-07-01

    The purpose of this paper is to show the design and evaluation of safety culture conducted in the Cofrentes nuclear plant. The process has combined the use of different methodologies and techniques and has allowed the participation of different internal and external stake holders. For internal assessment discussion groups were conducted. These groups, which were designed and analyzed by the CIEMAT, were led by employees from different levels of Cofrentes.

  12. Exploring Links between Internal and International Migration in Albania : a View from Internal Migrants

    NARCIS (Netherlands)

    Caro, Erka; Bailey, Ajay; Van Wissen, Leo J. G.

    Over the last 20years, Albania has experienced sweeping economic and social changes, caused in part by increasing internal and international migration flows. Migration trajectories of Albanians represent a combination of internal, international, and return migration. Whereas scholars have previously

  13. Linear Algebra and Smarandache Linear Algebra

    OpenAIRE

    Vasantha, Kandasamy

    2003-01-01

    The present book, on Smarandache linear algebra, not only studies the Smarandache analogues of linear algebra and its applications, it also aims to bridge the need for new research topics pertaining to linear algebra, purely in the algebraic sense. We have introduced Smarandache semilinear algebra, Smarandache bilinear algebra and Smarandache anti-linear algebra and their fuzzy equivalents. Moreover, in this book, we have brought out the study of linear algebra and ve...

  14. Linear Algebra and Smarandache Linear Algebra

    OpenAIRE

    Vasantha, Kandasamy

    2003-01-01

    The present book, on Smarandache linear algebra, not only studies the Smarandache analogues of linear algebra and its applications, it also aims to bridge the need for new research topics pertaining to linear algebra, purely in the algebraic sense. We have introduced Smarandache semilinear algebra, Smarandache bilinear algebra and Smarandache anti-linear algebra and their fuzzy equivalents. Moreover, in this book, we have brought out the study of linear algebra and ve...

  15. Research on the Teaching of Linear Algebra Combined with Mathematica Software%《线性代数》课程与Mathematica软件相结合教学的研究

    Institute of Scientific and Technical Information of China (English)

    张新艳; 邢利刚

    2014-01-01

    Linear Algebra is an important basic required courses in higher finance and economics undergraduate colleges, when students learn the course, there are difficulties in calculation, combine Mathematica software in teaching process can not only solve large amount of calcula-tion and complex issue, and can verify the accuracy of the results manually algorithm obtained, so as to achieve the purpose of improving the quality of teaching addition, students can master the use of Mathematica software initially.%《线性代数》是高等财经本科院校所开设的一门重要基础必修课,学生学习该课程时,在计算方面存在着困难,教学过程中结合使用Mathematica软件不但可以解决计算量大而复杂的问题,而且可以利用软件得到的结果来检验手工算法的准确性,从而达到提高教学质量的目的;另外,可以让学生初步掌握Mathematica软件的使用。

  16. Evaluation of a combined respiratory-gating system comprising the TrueBeam linear accelerator and a new real-time tumor-tracking radiotherapy system: a preliminary study.

    Science.gov (United States)

    Shiinoki, Takehiro; Kawamura, Shinji; Uehara, Takuya; Yuasa, Yuki; Fujimoto, Koya; Koike, Masahiro; Sera, Tatsuhiro; Emoto, Yuki; Hanazawa, Hideki; Shibuya, Keiko

    2016-07-08

    A combined system comprising the TrueBeam linear accelerator and a new real-time, tumor-tracking radiotherapy system, SyncTraX, was installed in our institution. The goals of this study were to assess the capability of SyncTraX in measuring the position of a fiducial marker using color fluoroscopic images, and to evaluate the dosimetric and geometric accuracy of respiratory-gated radiotherapy using this combined system for the simple geometry. For the fundamental evaluation of respiratory-gated radiotherapy using SyncTraX, the following were performed:1) determination of dosimetric and positional characteristics of sinusoidal patterns using a motor-driven base for several gating windows; 2) measurement of time delay using an oscilloscope; 3) positional verification of sinusoidal patterns and the pattern in the case of a lung cancer patient; 4) measurement of the half-value layer (HVL in mm AL), effective kVp, and air kerma, using a solid-state detector for each fluoroscopic condition, to determine the patient dose. The dose profile in a moving phantom with gated radiotherapy having a gating window ≤ 4 mm was in good agreement with that under static conditions for each photon beam. The total time delay between TrueBeam and SyncTraX was < 227 ms for each photon beam. The mean of the positional tracking error was < 0.4 mm for sinusoidal patterns and for the pattern in the case of a lung cancer patient. The air-kerma rates from one fluoroscopy direction were 1.93 ± 0.01, 2.86 ± 0.01, 3.92 ± 0.04, 5.28 ± 0.03, and 6.60 ± 0.05 mGy/min for 70, 80, 90, 100, and 110 kV X-ray beams at 80 mA, respectively. The combined system comprising TrueBeam and SyncTraX could track the motion of the fiducial marker and control radiation delivery with reasonable accuracy; therefore, this system provides significant dosimetric improvement. However, patient exposure dose from fluoroscopy was not clinically negligible.

  17. FRACTIONAL DIFFUSION EQUATIONS WITH INTERNAL DEGREES OF FREEDOM

    Institute of Scientific and Technical Information of China (English)

    Luis Vázquez

    2003-01-01

    We present a generalization of the linear one-dimensional diffusion equation by combining the fractional derivatives and the internal degrees of freedom. The solutions are constructed from those of the scalar fractional diffusion equation. We analyze the interpolation between the standard diffusion and wave equations defined by the fractional derivatives. Our main result is that we can define a diffusion process depending on the internal degrees of freedom associated to the system.

  18. Linearized Kernel Dictionary Learning

    Science.gov (United States)

    Golts, Alona; Elad, Michael

    2016-06-01

    In this paper we present a new approach of incorporating kernels into dictionary learning. The kernel K-SVD algorithm (KKSVD), which has been introduced recently, shows an improvement in classification performance, with relation to its linear counterpart K-SVD. However, this algorithm requires the storage and handling of a very large kernel matrix, which leads to high computational cost, while also limiting its use to setups with small number of training examples. We address these problems by combining two ideas: first we approximate the kernel matrix using a cleverly sampled subset of its columns using the Nystr\\"{o}m method; secondly, as we wish to avoid using this matrix altogether, we decompose it by SVD to form new "virtual samples," on which any linear dictionary learning can be employed. Our method, termed "Linearized Kernel Dictionary Learning" (LKDL) can be seamlessly applied as a pre-processing stage on top of any efficient off-the-shelf dictionary learning scheme, effectively "kernelizing" it. We demonstrate the effectiveness of our method on several tasks of both supervised and unsupervised classification and show the efficiency of the proposed scheme, its easy integration and performance boosting properties.

  19. Linearity Testing of Photovoltaic Cells

    Energy Technology Data Exchange (ETDEWEB)

    Pinegar, S.; Nalley, D.; Emery, K.

    2006-01-01

    Photovoltaic devices are rated in terms of their power output or efficiency with respect to a specific spectrum, total irradiance, and temperature. In order to rate photovoltaic devices, a reference detector whose response is linear with total irradiance is needed. This procedure documents a procedure to determine if a detector is linear over the irradiance range of interest. Testing the short circuit current versus the total irradiance is done by illuminating a reference cell candidate with two lamps that are fitted with programmable filter wheels. The purpose is to reject nonlinear samples as determined by national and international standards from being used as primary reference cells. A calibrated linear reference cell tested by the two lamp method yields a linear result.

  20. Linearity Testing of Photovoltaic Cells

    Energy Technology Data Exchange (ETDEWEB)

    Pinegar, S.; Nalley, D.; Emery, K.

    2006-01-01

    Photovoltaic devices are rated in terms of their power output or efficiency with respect to a specific spectrum, total irradiance, and temperature. In order to rate photovoltaic devices, a reference detector whose response is linear with total irradiance is needed. This procedure documents a procedure to determine if a detector is linear over the irradiance range of interest. Testing the short circuit current versus the total irradiance is done by illuminating a reference cell candidate with two lamps that are fitted with programmable filter wheels. The purpose is to reject nonlinear samples as determined by national and international standards from being used as primary reference cells. A calibrated linear reference cell tested by the two lamp method yields a linear result.

  1. CERN balances linear collider studies

    CERN Multimedia

    ILC Newsline

    2011-01-01

    The forces behind the two most mature proposals for a next-generation collider, the International Linear Collider (ILC) and the Compact Linear Collider (CLIC) study, have been steadily coming together, with scientists from both communities sharing ideas and information across the technology divide. In a support of cooperation between the two, CERN in Switzerland, where most CLIC research takes place, recently converted the project-specific position of CLIC Study Leader to the concept-based Linear Collider Study Leader.   The scientist who now holds this position, Steinar Stapnes, is charged with making the linear collider a viable option for CERN’s future, one that could include either CLIC or the ILC. The transition to more involve the ILC must be gradual, he said, and the redefinition of his post is a good start. Though not very much involved with superconducting radiofrequency (SRF) technology, where ILC researchers have made significant advances, CERN participates in many aspect...

  2. Extension of the cubic uniform B-spline curve based on the linear combination of curves%基于曲线线性组合的3次均匀B样条曲线的拓展

    Institute of Scientific and Technical Information of China (English)

    梁锡坤

    2011-01-01

    为了丰富和发展B样条曲线理论,利用曲线线性组合的思想,将3次均匀B样条曲线进行了拓展,并讨论了拓展曲线的性质.研究表明,拓展曲线的基具有较简单的表达式;拓展曲线包含了原曲线的基本形式,比原曲线具有更强的描述能力,且保持曲线次数不变.利用曲线的形状因子可以调整曲线的局部形状;同时得到了一种闭曲线表示的新途径.%In order to develop the theory of B-spline curve, the representation of cubic uniform B-spline curve is extended to a general form based on linear combination of curves.Moreover, some properties of the extended curve are discussed in details.The research shows that the basis of the generalized curve is relative simple, and the extended curve includes the original B-spline curve and shows much better shape-control capability than the original curve.Meanwhile, the extended curve keeps the same degree of original one.It is easy to find that the curve can be reshape by adjusting the shape factor.Also, a new method of the representation of closed curve is given.

  3. 农村低保线评估--基于需求层次与扩展线性支出法测算%Estimates Rural Poverty Line:Measurement Hierarchy of Needs Combined with the Extended Linear Expenditure

    Institute of Scientific and Technical Information of China (English)

    江华; 杨雪

    2014-01-01

    本文依据社会保障基本理论,将需求层次和扩展线性支出系统结合,测算2006~2010年全国平均农村居民低保线和2010年东、中、西部地区代表省份的农村低保线,分别从城乡低保线对比、现行低保线以及测算低保线与农村居民生活支出比重、可支配收入比重、与CPI之间的联动机制等方面对比分析,并考察测算过程中的β值,评估农村现行低保线,提出进一步改进的建议。%Based on the basic theory of social security , the paper combines Hierarchy of Needs Theory and the Extended Linear Expenditure System , to amend the measurements of poverty line through the ELES.It estimates the national average urban and rural poverty line from 2006 to 2010, and urban poverty line among representative of Eastern-middle-western Province in 2010.This paper tends to test and amend the result of ELES , and meanwhile indicates some further improvements in the following five aspects: Comparison of urban and rural poor line , ratio of poverty line and the expenditure of urban and rural residents , proportion estimation between poverty line and disposable income of urban and rural residents , linkage mechanism between the existing poverty line and the CPI, and the steady decrease of income dependent coefficient during the calculation process .

  4. Combination of solid phase extraction and dispersive liquid–liquid microextraction for separation/preconcentration of ultra trace amounts of uranium prior to its fiber optic-linear array spectrophotometry determination

    Energy Technology Data Exchange (ETDEWEB)

    Dadfarnia, Shayessteh, E-mail: sdadfarnia@yazd.ac.ir; Shabani, Ali Mohammad Haji; Shakerian, Farid; Shiralian Esfahani, Golnaz

    2013-12-15

    Graphical abstract: Pass the sample through the basic alumina column ⇒ elute retained uranium along with the cations ⇒ convert the uranium to its anionic benzoate complex ⇒ extract its ion pair with malachite green into small volume of chloroform by DLLME ⇒ measure its absorption at 621 nm using fiber optic-linear array detection spectrophotometry. -- Highlights: • By combination of SPE and DDLME a high preconcentration factor of 2500 was obtained. • Development of SPE-DDLME-Spectrophotometric method for det. of trace amounts of uranium. • Ultra trace amount of uranium in water samples was det. by the proposed method. • The detection limit of the proposed method is comparable to the most sensitive method. • The proposed method is a free interference spectrophotometric method for uranium det. -- Abstract: A simple and sensitive method for the separation and preconcentration of the ultra trace amounts of uranium and its determination by spectrophotometry was developed. The method is based on the combination of solid phase extraction and dispersive liquid–liquid microextraction. Thus, by passing the sample through the basic alumina column, the uranyl ion and some cations are separated from the sample matrix. The retained uranyl ion along with the cations are eluted with 5 mL of nitric acid (2 mol L{sup −1}) and after neutralization of the eluent, the extracted uranyl ion is converted to its anionic benzoate complex and is separated from other cations by extraction of its ion pair with malachite green into small volume of chloroform using dispersive liquid–liquid microextraction. The amount of uranium is then determined by the absorption measurement of the extracted ion pair at 621 nm using flow injection spectrophotometry. Under the optimum conditions, with 500 mL of the sample, a preconcentration factor of 1980, a detection limit of 40 ng L{sup −1}, and a relative standard deviation of 4.1% (n = 6) at 400 ng L{sup −1} were obtained. The

  5. Uso combinado de sistemas de informações geográficas para transportes e programação linear inteira mista em problemas de localização de instalações Combining geographic information systems for transportation and mixed integer linear programming in location-allocation problems

    Directory of Open Access Journals (Sweden)

    Sílvia Maria Santana Mapa

    2012-01-01

    Full Text Available O objetivo do trabalho é avaliar a qualidade das soluções para o problema de localização-alocação de instalações geradas por um SIG-T (Sistema de Informação Geográfica para Transportes, obtidas após a utilização combinada das rotinas Localização de Facilidades e Problema do Transporte, quando comparadas com as soluções ótimas obtidas a partir de modelo matemático exato baseado em Programação Linear Inteira Mista (PLIM, desenvolvido externamente ao SIG. Os modelos foram aplicados a três simulações: a primeira propõe a abertura de fábricas e alocação de clientes no Estado de São Paulo; a segunda envolve um atacadista e um estudo de localização de centros de distribuição e alocação dos clientes varejistas; a terceira localiza creches em um contexto urbano, alocando a demanda. Os resultados mostraram que, quando se considera a capacidade das instalações, o modelo otimizante PLIM chegou a apresentar, em um dos cenários simulados, resultados até 37% melhores do que o SIG, além de propor locais diferentes para abertura de novas instalações. Quando não se considera a capacidade, o modelo SIG se mostrou tão eficiente quanto o modelo exato PLIM, chegando exatamente às mesmas soluções.This study aims to evaluate the quality of the solutions for facility location-allocation problems generated by a GIS-T (Geographic Information System for Transportation software. These solutions were obtained from combining the Facility Location and Transportation Problem routines, when compared with the optimal solutions, which were obtained using the exact mathematical model based on the Mixed Integer Linear Programming (MILP developed externally to the GIS. The models were applied to three simulations: the first one proposes set up businesses and customers' allocation in the state of São Paulo; the second involves a wholesaler and an investigation of distribution center location and retailers' allocation; and the third one

  6. Linear geometry thyratron

    Science.gov (United States)

    Byron, S.

    1985-03-01

    The low pressure gas-filled thyratron is scalable in the long dimension. Internally the tube is formed as a tetrode, with an auxiliary grid placed between the cathode and the control grid. A dc or pulsed power source drives the auxiliary grid both to insure uniform cathode emission and to provide a grid-cathode plasma prior to commutation. The high voltage holdoff structure consists of the anode, the control grid and its electrostatic shielding baffles, and a main quartz insulator. A small gas flow supply and exhaust system is used that eliminates the need for a hydrogen reservoir and permits other gases, such as helium, to be used. The thyratron provides a low inductance, high current, long lifetime switch configuration: useful for switch-on applications involving large scale lasers and other similar loads that are distributed in a linear geometry.

  7. A broad G protein-coupled receptor internalization assay that combines SNAP-tag labeling, diffusion-enhanced resonance energy transfer, and a highly emissive terbium cryptate acceptor

    Directory of Open Access Journals (Sweden)

    Angélique eLEVOYE

    2015-11-01

    Full Text Available Although G protein-coupled receptor (GPCR internalization has long been considered a major aspect of the desensitization process that tunes ligand responsiveness, internalization is also involved in receptor resensitization and signaling, as well as the ligand scavenging function of some atypical receptors. Internalization thus contributes to the diversity of GPCR-dependent signaling, and its dynamics and quantification in living cells has generated considerable interest. We developed a robust and sensitive assay to follow and quantify ligand-induced and constitutive GPCR internalization but also receptor recycling in living cells. This assay is based on diffusion-enhanced resonance energy transfer (DERET between cell surface GPCRs labeled with a luminescent terbium cryptate donor and a fluorescein acceptor present in the culture medium. GPCR internalization results in a quantifiable reduction of energy transfer. This method yields a high signal-to-noise ratio due to time-resolved measurements. For various GPCRs belonging to different classes, we demonstrated that constitutive and ligand-induced internalization could be monitored as a function of time and ligand concentration, thus allowing accurate quantitative determination of kinetics of receptor internalization but also half-maximal effective or inhibitory concentrations of compounds. In addition to its selectivity and sensitivity, we provided evidence that DERET-based internalization assay is particularly suitable for characterizing biased ligands. Furthermore, the determination of a Z’-factor value of 0.45 indicates the quality and suitability of DERET-based internalization assay for high-throughput screening (HTS of compounds that may modulate GPCRs internalization.

  8. A Broad G Protein-Coupled Receptor Internalization Assay that Combines SNAP-Tag Labeling, Diffusion-Enhanced Resonance Energy Transfer, and a Highly Emissive Terbium Cryptate.

    Science.gov (United States)

    Levoye, Angélique; Zwier, Jurriaan M; Jaracz-Ros, Agnieszka; Klipfel, Laurence; Cottet, Martin; Maurel, Damien; Bdioui, Sara; Balabanian, Karl; Prézeau, Laurent; Trinquet, Eric; Durroux, Thierry; Bachelerie, Françoise

    2015-01-01

    Although G protein-coupled receptor (GPCR) internalization has long been considered as a major aspect of the desensitization process that tunes ligand responsiveness, internalization is also involved in receptor resensitization and signaling, as well as the ligand scavenging function of some atypical receptors. Internalization thus contributes to the diversity of GPCR-dependent signaling, and its dynamics and quantification in living cells has generated considerable interest. We developed a robust and sensitive assay to follow and quantify ligand-induced and constitutive-induced GPCR internalization but also receptor recycling in living cells. This assay is based on diffusion-enhanced resonance energy transfer (DERET) between cell surface GPCRs labeled with a luminescent terbium cryptate donor and a fluorescein acceptor present in the culture medium. GPCR internalization results in a quantifiable reduction of energy transfer. This method yields a high signal-to-noise ratio due to time-resolved measurements. For various GPCRs belonging to different classes, we demonstrated that constitutive and ligand-induced internalization could be monitored as a function of time and ligand concentration, thus allowing accurate quantitative determination of kinetics of receptor internalization but also half-maximal effective or inhibitory concentrations of compounds. In addition to its selectivity and sensitivity, we provided evidence that DERET-based internalization assay is particularly suitable for characterizing biased ligands. Furthermore, the determination of a Z'-factor value of 0.45 indicates the quality and suitability of DERET-based internalization assay for high-throughput screening (HTS) of compounds that may modulate GPCRs internalization.

  9. Assessment of global reporting of adverse drug reactions for anti-malarials, including artemisinin-based combination therapy, to the WHO Programme for International Drug Monitoring

    Directory of Open Access Journals (Sweden)

    Van Erps Jan

    2011-03-01

    Full Text Available Abstract Background In spite of enhanced control efforts, malaria remains a major public health problem causing close to a million deaths annually. With support from several donors, large amounts of artemisinin-based combination therapy (ACT are being deployed in endemic countries raising safety concerns as little is known about the use of ACT in several of the settings where they are deployed. This project was undertaken to profile the provenance of the pharmacovigilance reporting of all anti-malarials, including ACT to the WHO adverse drug reaction (ADR database (Vigibase™ over the past 40 years. Methods The WHO Programme for International Drug Monitoring, the Uppsala Monitoring Centre (UMC provided anonymized extracts of Vigibase™ covering the period 1968-2008. All countries in the programme were clustered according to their malaria control phase and income status. The number of individual case safety reports (ICSRs of anti-malarials was analyzed according to those clusters. Results From 1968 to 2008, 21,312 ICSRs suspecting anti-malarials were received from 64 countries. Low-income countries, that are also malaria-endemic (categorized as priority 1 countries submitted only 1.2% of the ICSRs. Only 60 out of 21,312 ICSRs were related to ACT, 51 of which were coming from four sub-Saharan African countries. Although very few ICSRs involved artemisinin-based compounds, many of the adverse events reported were potentially serious. Conclusions This paper illustrates the low reporting of ADRs to anti-malarials in general and ACT in particular. Most reports were submitted by non-endemic and/or high-income countries. Given the current mix of large donor funding, the insufficient information on safety of these drugs, increasing availability of ACT and artemisinin-based monotherapies in public and private sector channels, associated potential for inappropriate use and finally a pipeline of more than 10 new novel anti-malarials in various stages of

  10. Research and design of bidirectional power converter for internal combustion linear power generation system%内燃直线发电系统双向功率变换器研究与设计

    Institute of Scientific and Technical Information of China (English)

    毛莲莲; 张驰; 高艳霞; 赵飞; 孙鹏; 曾德全

    2016-01-01

    The free⁃piston internal combustion linear power generation system is a novel integrated hybrid power system. In the process of system start to stable operation,the power flows between power generation unit and energy storage unit bidirectionally through BDPC,and has the unbalanced characteristics in two directions,which makes the designed inductor in Buck mode have big volume and high cost,and the switching tube have large current stress. Aiming at this problem,it is proposed that the BDPC adopts the single phase structure in Boost mode,and adopts the staggered parallel structure in Buck mode,which can re⁃duce the inductor volume and cost,current stress of the switching tube,and output current ripple. To meet the system transient demand,the fuzzy PI controller is used for the voltage loop of BDPC controller to realize the fast system response,and improve the system robustness.%自由活塞式内燃直线发电系统是一种新型集成混合动力系统,在系统启动到稳定运行过程中,功率流经由BDPC在发电单元与储能单元之间双向流动,且在两个方向具有不平衡特性,使得Buck模式下设计电感体积大,成本高,开关管电流应力大。针对此问题,提出BDPC在Boost模式时采用单相结构,在Buck模式时采用交错并联结构,从而有效减小电感体积和成本,减小开关管电流应力,降低输出电流纹波。此外,为满足系统瞬态需求,在BDPC控制器电压环采用模糊PI控制器,实现了更快的系统响应,提高了系统鲁棒性。

  11. EDITORIAL: Invited papers from the 15th International Congress on Plasma Physics combined with the 13th Latin American Workshop on Plasma Physics Invited papers from the 15th International Congress on Plasma Physics combined with the 13th Latin American Workshop on Plasma Physics

    Science.gov (United States)

    Soto, Leopoldo

    2011-07-01

    The International Advisory Committee of the 15th International Congress on Plasma Physics (ICPP 2010) and the International Advisory Committee of the 13th Latin American Workshop on Plasma Physics (LAWPP 2010) both agreed to hold this combined meeting ICPP-LAWPP-2010 in Santiago de Chile, 8-13 August 2010, considering the celebration of the Bicentennial of Chilean Independence. ICPP-LAWPP-2010 was organized by the Thermonuclear Plasma Department of the Chilean Nuclear Energy Commission (CCHEN) as part of its official program, within the framework of the Chilean Bicentennial activities. This event was also a scientific and academic activity of the project `Center for Research and Applications in Plasma Physics and Pulsed Power, P4', supported by the National Scientific and Technological Commission, CONICYT-Chile, under grant ACT-26. The International Congress on Plasma Physics was first held in Nagoya in 1980, and was followed by: Gothenburg (1982), Lausanne (1984), Kiev (1987), New Delhi (1989), Innsbruck (1992), Foz do Iguacu (1994), Nagoya (1996), Prague (1998), Quebec City (2000), Sydney (2002), Nice (2004), Kiev (2006) and Fukuoka (2008). The purpose of the Congress is to discuss recent progress and outlooks in plasma science, covering fundamental plasma physics, fusion plasmas, astrophysical plasmas, plasma applications, etc. The Latin American Workshop on Plasma Physics was first held in 1982 in Cambuquira, Brazil, followed by: Medellín (1985), Santiago (1988), Buenos Aires (1990), Mexico City (1992), Foz do Iguacu (1994, also combined with ICPP), Caracas (1997), Tandil (1998), La Serena (2000), Sao Pedro (2003), Mexico City (2005) and Caracas (2007). The purpose of the Latin American Workshop on Plasma Physics is to provide a forum in which the achievements of the Latin American plasma physics communities can be displayed, as well as to foster collaboration between plasma scientists within the region and elsewhere. The Program of ICPP-LAWPP-2010 included

  12. Stability analysis and non-linear behaviour of structural systems using the complex non-linear modal analysis (CNLMA)

    OpenAIRE

    Sinou, Jean-Jacques; Thouverez, Fabrice; Jezequel, Louis

    2006-01-01

    International audience; Herein, a novel non-linear procedure for producing non-linear behaviour and stable limit cycle amplitudes of non-linear systems subjected to super-critical Hopf bifurcation point is presented. This approach, called Complex Non-Linear Modal Analysis (CNLMA), makes use of the non-linear unstable mode which governs the non-linear dynamic of structural systems in unstable areas. In this study, the computational methodology of CNLMA is presented for the systematic estimatio...

  13. Linearly constrained minimax optimization

    DEFF Research Database (Denmark)

    Madsen, Kaj; Schjær-Jacobsen, Hans

    1978-01-01

    We present an algorithm for nonlinear minimax optimization subject to linear equality and inequality constraints which requires first order partial derivatives. The algorithm is based on successive linear approximations to the functions defining the problem. The resulting linear subproblems...

  14. Non-linear Ultrasound Imaging

    DEFF Research Database (Denmark)

    Du, Yigang

    without iteration steps. The ASA is implemented in combination with Field II and extended to simulate the pulsed ultrasound fields. The simulated results from a linear array transducer are made by the ASA based on Field II, and by a released non-linear simulation program- Abersim, respectively....... The calculation speed of the ASA is increased approximately by a factor of 140. For the second harmonic point spread function the error of the full width is 1.5% at -6 dB and 6.4% at -12 dB compared to Abersim. To further investigate the linear and non-linear ultrasound fields, hydrophone measurements.......3% relative to the measurement from a 1 inch diameter transducer. A preliminary study for harmonic imaging using synthetic aperture sequential beamforming (SASB) has been demonstrated. A wire phantom underwater measurement is made by an experimental synthetic aperture real-time ultrasound scanner (SARUS...

  15. Acoustic emission linear pulse holography

    Science.gov (United States)

    Collins, H.D.; Busse, L.J.; Lemon, D.K.

    1983-10-25

    This device relates to the concept of and means for performing Acoustic Emission Linear Pulse Holography, which combines the advantages of linear holographic imaging and Acoustic Emission into a single non-destructive inspection system. This unique system produces a chronological, linear holographic image of a flaw by utilizing the acoustic energy emitted during crack growth. The innovation is the concept of utilizing the crack-generated acoustic emission energy to generate a chronological series of images of a growing crack by applying linear, pulse holographic processing to the acoustic emission data. The process is implemented by placing on a structure an array of piezoelectric sensors (typically 16 or 32 of them) near the defect location. A reference sensor is placed between the defect and the array.

  16. On the Teaching of Linear Algebra

    OpenAIRE

    Dorier, Jean-Luc

    2000-01-01

    The book present the state-of-art research on the teaching and learning of linear algebra in the fist year of university, in an international perspective. It aims at giving to university teachers in charge of linear algebra courses a wide range of information from works including theoretical and experimental issues. These works try to better understand the meaning of linear algebra in an epistemological approach, as well as the constraints and the difficulties in its teaching and learning. Th...

  17. Combination therapy with metoprolol and nifedipine versus monotherapy in patients with stable angina pectoris. Results of the International Multicenter Angina Exercise (IMAGE) Study

    DEFF Research Database (Denmark)

    Savonitto, S; Ardissiono, D; Egstrup, K

    1996-01-01

    10, the groups randomized to combination therapy had a further increase in time to 1-mm ST segment depression (p ...OBJECTIVES: This study was designed to investigate whether combination therapy with metoprolol and nifedipine provides a greater anti-ischemic effect than does monotherapy in individual patients with stable angina pectoris. BACKGROUND: Combination therapy with a beta-adrenergic blocking agent...... (which reduces myocardial oxygen consumption) and a dihydropyridine calcium antagonist (which increases coronary blood flow) is a logical approach to the treatment of stable angina pectoris. However, it is not clear whether, in individual patients, this combined therapy is more effective than monotherapy...

  18. Authors' reply to Discussion by E. Siebrits and S. L. Crouch regarding the paper "A two-dimensional linear variation displacement discontinuity method for three-layered elastic media", International Journal of Rock Mechanics and Mining Sciences, Vol. 36, No. 6, pp. 719-729, 1999

    CSIR Research Space (South Africa)

    Shou, KJ

    2000-07-01

    Full Text Available to Discussion by E. Siebrits and S. L. Crouch regarding the paper ``A two-dimensional linear variation displacement discontinuity method for three-layered elastic media'', International Journal of Rock Mechanics and Mining Sciences, Vol. 36, No. 6, pp. 719... of judging the accuracy of their ``highly accurate semi-analytic simulator'' which is International Journal of Rock Mechanics and Mining Sciences 37 (2000) 877±878 1365-1609/00/$ - see front matter 7 2000 Elsevier Science Ltd. All rights reserved. PII: S...

  19. Foundations of linear and generalized linear models

    CERN Document Server

    Agresti, Alan

    2015-01-01

    A valuable overview of the most important ideas and results in statistical analysis Written by a highly-experienced author, Foundations of Linear and Generalized Linear Models is a clear and comprehensive guide to the key concepts and results of linear statistical models. The book presents a broad, in-depth overview of the most commonly used statistical models by discussing the theory underlying the models, R software applications, and examples with crafted models to elucidate key ideas and promote practical model building. The book begins by illustrating the fundamentals of linear models,

  20. Logistic systems with linear feedback

    Science.gov (United States)

    Son, Leonid; Shulgin, Dmitry; Ogluzdina, Olga

    2016-08-01

    A wide variety of systems may be described by specific dependence, which is known as logistic curve, or S-curve, between the internal characteristic and the external parameter. Linear feedback between these two values may be suggested for a wide set of systems also. In present paper, we suggest a bifurcation behavior for systems with both features, and discuss it for two cases, which are the Ising magnet in external field, and the development of manufacturing enterprise.

  1. Non-Linear Rheological Properties and Neutron Scattering Investigation on Dilute Ring-Linear Blends

    DEFF Research Database (Denmark)

    Pyckhout-Hintzen, W.; Bras, A.R.; Wischnewski, A.;

    Linear and non-linear Rheology on dilute blends of polystyrene ring polymers in linear matrix is combined with Small Angle Neutron Scattering (SANS) investigations. In this way 2 different entanglement interactions become clear. After stretching the samples to different hencky strains up to 2 in ...

  2. 1993 International conference on nuclear waste management and environmental remediation, Prague, Czech Republic, September 5--11, 1993. Combined foreign trip report

    Energy Technology Data Exchange (ETDEWEB)

    Slate, S.C. [comp.; Allen, R.E. [ed.

    1993-12-01

    The purpose of the trip was to attend the 1993 International Conference on Nuclear Waste Management and Environmental Remediation. The principal objective of this conference was to facilitate a truly international exchange of information on the management of nuclear wastes as well as contaminated facilities and sites emanating from nuclear operations. The conference was sponsored by the American Society of Mechanical Engineers, the Czech and Slovak Mechanical Engineering Societies, and the Czech and Slovak Nuclear Societies in cooperation with the Commission of the European Communities, the International Atomic Energy Agency, and the OECD Nuclear Agency. The conference was cosponsored by the American Nuclear Society, the Atomic Energy Society of Japan, the Canadian Nuclear Society, the (former USSR) Nuclear Society, and the Japan Society of Mechanical Engineers. This was the fourth in a series of biennial conferences, which started in Hong Kong, in 1987. This report summarizes shared aspects of the trip; however, each traveler`s observations and recommendations are reported separately.

  3. Feedback linearization of piecewise linear systems

    NARCIS (Netherlands)

    Camlibel, Kanat; Ustoglu, Ilker

    2005-01-01

    One of the classical problems of nonlinear systems and control theory is feedback linearization. Its obvious motivation is that one can utilize linear control theory if the nonlinear system at hand is linearizable by feedback. This problem is well-understood for the smooth nonlinear systems. In the

  4. COMPARATIVE PERFORMANCE STUDY OF GASKETED AND NON-GASKETED FLANGE JOINTS UNDER COMBINED INTERNAL PRESSURE, AXIAL AND BENDING LOADING – AN EXPERIMENTAL STUDY

    Directory of Open Access Journals (Sweden)

    Muhammad Abid

    2010-11-01

    Full Text Available In this paper result of an extensive comparative experimental study of a gasketed and non-gasketed flange joint with different assemblies with different combined load combinations is carried out to investigate joint performance i.e. joint strength and sealing capability. Actual joint load capacities are determined under both the design and proof test pressure with maximum additional external loading (axial and bending that can be applied for safe joint performance. In addition, application of combined load is also discussed in the light of equivalent pressure approach.

  5. Validation of an Internet-Based Long Version of the International Physical Activity Questionnaire in Danish Adults Using Combined Accelerometry and Heart Rate Monitoring

    DEFF Research Database (Denmark)

    Hansen, Andreas Wolff; Dahl-Petersen, Inger; Helge, Jørn Wulff

    2014-01-01

    BACKGROUND: The International Physical Activity Questionnaire (IPAQ) is commonly used in surveys but reliability and validity has not been established in the Danish population. METHODS: Among participants in the Danish Health Examination survey 2007-2008, 142 healthy participants (45% men) wore...

  6. German lab wins linear collider contest

    CERN Multimedia

    Cartlidge, Edwin

    2004-01-01

    Particle physicists have chosen to base the proposed International Linear Collider on superconducting technology developed by an international collaboration centred on the DESY lab in Germany. The superconducting approach was chosen by an internatinal panel ahead of a rival technology developed at Stanford in the US and the KEK lab in Japan. The eagerly-awaited decision was announced at the International Conference on High Energy Physics in Beijing today (½ page)

  7. Theoretical analysis of balanced truncation for linear switched systems

    DEFF Research Database (Denmark)

    Petreczky, Mihaly; Wisniewski, Rafal; Leth, John-Josef

    2012-01-01

    In this paper we present theoretical analysis of model reduction of linear switched systems based on balanced truncation, presented in [1,2]. More precisely, (1) we provide a bound on the estimation error using L2 gain, (2) we provide a system theoretic interpretation of grammians...... for showing this independence is realization theory of linear switched systems. [1] H. R. Shaker and R. Wisniewski, "Generalized gramian framework for model/controller order reduction of switched systems", International Journal of Systems Science, Vol. 42, Issue 8, 2011, 1277-1291. [2] H. R. Shaker and R....... Wisniewski, "Switched Systems Reduction Framework Based on Convex Combination of Generalized Gramians", Journal of Control Science and Engineering, 2009....

  8. Increasing reliability of gas-air systems of piston and combined internal combustion engines by improving thermal and mechanic flow characteristics

    Science.gov (United States)

    Brodov, Yu. M.; Grigor'ev, N. I.; Zhilkin, B. P.; Plotnikov, L. V.; Shestakov, D. S.

    2015-12-01

    Results of experimental study of thermal and mechanical characteristics of gas exchange flow in piston and combined engines are presented. Ways for improving intake and exhaust processes to increase reliability of gas-air engine systems are proposed.

  9. Temporary heat storage by using combined heat and power in supplementary lighted greenhouses Proceedings of the Third International Symposium on Artificial Lighting in Horticulture

    NARCIS (Netherlands)

    Huijs, J.P.G.

    1997-01-01

    Because of better utilization possibilities of the produced heat, decentrally located combined heat and power installations achieve a higher energetic efficiency than producing heat and power separately. However, efficiency depends considerably on synchronism of heat and electricity demand. Using a

  10. COMPARISON OF LINEAR CONTROLLERS FOR A

    DEFF Research Database (Denmark)

    Andersen, Torben Ole; Hansen, Michael Rygaard; Pedersen, Henrik C.;

    2005-01-01

    In many hydraulic control applications, classic linear controllers are still employed, although there exist a number of number of nonlinear control methods, which may be better suited for handling the intrensic non-linearities often found in hydraulic systems. The focus of this paper is therefore...... on comparing different linear controllers, based on both simulation and experimental results, to determine what is obtainable when applying standard linear controllers to a hydraulic SISO servo system. The paper furthermore addresses how the performance may be improved by using internal pressure control...

  11. Internal standards for use in the comprehensive analysis of polychlorinated aromatic hydrocarbons using gas chromatography combined with multiphoton ionization mass spectrometry.

    Science.gov (United States)

    Li, Adan; Imasaka, Totaro

    2016-10-28

    To decrease health-risks to humans, non-toxic compounds were evaluated for use as internal standards for calibrating data obtained by gas chromatography/multiphoton ionization mass spectrometry (GC-MPI-MS) using an ultraviolet femtosecond laser as the ionization source. The retention time in the mass chromatogram was calibrated using a retention index, in which a series of n-alkanes was employed as internal standards for evaluating the retention times for polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs). To compensate for changes in signal intensity in MPI-MS, the dependence of signal intensity on the laser pulse energy was investigated for the dioxin-like compounds, in addition to five non-toxic aromatic hydrocarbons, that were used as internal standards. Based on their similar behavior,the non-toxic PCDD/PCDF, its (13)C-isotope, and pentachlorobenzene behave similarly, we conclude that they can be used for calibrating the signal intensities in MPI-MS. Copyright © 2016 Elsevier B.V. All rights reserved.

  12. Linear methods in band theory

    DEFF Research Database (Denmark)

    Andersen, O. Krogh

    1975-01-01

    and they specify the boundary conditions on a single MT or atomic sphere in the most convenient way. This method is very well suited for self-consistent calculations. The empty-lattice test is applied to the linear-MTO method and the free-electron energy bands are accurately reproduced. Finally, it is shown how......Two approximate methods for solving the band-structure problem in an efficient and physically transparent way are presented and discussed in detail. The variational principle for the one-electron Hamiltonian is used in both schemes, and the trial functions are linear combinations of energy......-independent augmented plane waves (APW) and muffin-tin orbitals (MTO), respectively. The secular equations are therefore eigenvalue equations, linear in energy. The trial functions are defined with respect to a muffin-tin (MT) potential and the energy bands depend on the potential in the spheres through potential...

  13. Bayes linear statistics, theory & methods

    CERN Document Server

    Goldstein, Michael

    2007-01-01

    Bayesian methods combine information available from data with any prior information available from expert knowledge. The Bayes linear approach follows this path, offering a quantitative structure for expressing beliefs, and systematic methods for adjusting these beliefs, given observational data. The methodology differs from the full Bayesian methodology in that it establishes simpler approaches to belief specification and analysis based around expectation judgements. Bayes Linear Statistics presents an authoritative account of this approach, explaining the foundations, theory, methodology, and practicalities of this important field. The text provides a thorough coverage of Bayes linear analysis, from the development of the basic language to the collection of algebraic results needed for efficient implementation, with detailed practical examples. The book covers:The importance of partial prior specifications for complex problems where it is difficult to supply a meaningful full prior probability specification...

  14. Traffic, asthma and genetics : combining international birth cohort data to examine genetics as a mediator of traffic-related air pollution's impact on childhood asthma

    NARCIS (Netherlands)

    MacIntyre, Elaina A.; Carlsten, Christopher; MacNutt, Meaghan; Fuertes, Elaine; Melen, Eric; Tiesler, Carla M. T.; Gehring, Ulrike; Kraemer, Ursula; Kluemper, Claudia; Kerkhof, Marjan; Chan-Yeung, Moira; Kozyrskyj, Anita L.; Berdel, Dietrich; Bauer, Carl Peter; Herbarth, Olf; Bauer, Mario; Schaaf, Beate; Koletzko, Sibylle; Pershagen, Goran; Brunekreef, Bert; Heinrich, Joachim; Brauer, Michael

    Associations between traffic-related air pollution and incident childhood asthma can be strengthened by analysis of gene-environment interactions, but studies have typically been limited by lack of study power. We combined data from six birth cohorts on: asthma, eczema and allergic rhinitis to 7/8

  15. A linear programming manual

    Science.gov (United States)

    Tuey, R. C.

    1972-01-01

    Computer solutions of linear programming problems are outlined. Information covers vector spaces, convex sets, and matrix algebra elements for solving simultaneous linear equations. Dual problems, reduced cost analysis, ranges, and error analysis are illustrated.

  16. Multivariate covariance generalized linear models

    DEFF Research Database (Denmark)

    Bonat, W. H.; Jørgensen, Bent

    2016-01-01

    We propose a general framework for non-normal multivariate data analysis called multivariate covariance generalized linear models, designed to handle multivariate response variables, along with a wide range of temporal and spatial correlation structures defined in terms of a covariance link...... function combined with a matrix linear predictor involving known matrices. The method is motivated by three data examples that are not easily handled by existing methods. The first example concerns multivariate count data, the second involves response variables of mixed types, combined with repeated...... are fitted by using an efficient Newton scoring algorithm based on quasi-likelihood and Pearson estimating functions, using only second-moment assumptions. This provides a unified approach to a wide variety of types of response variables and covariance structures, including multivariate extensions...

  17. Comet LINEAR Splits Further

    Science.gov (United States)

    2001-05-01

    Third Nucleus Observed with the VLT Summary New images from the VLT show that one of the two nuclei of Comet LINEAR (C/2001 A2), now about 100 million km from the Earth, has just split into at least two pieces . The three fragments are now moving through space in nearly parallel orbits while they slowly drift apart. This comet will pass through its perihelion (nearest point to the Sun) on May 25, 2001, at a distance of about 116 million kilometres. It has brightened considerably due to the splitting of its "dirty snowball" nucleus and can now be seen with the unaided eye by observers in the southern hemisphere as a faint object in the southern constellation of Lepus (The Hare). PR Photo 18a/01 : Three nuclei of Comet LINEAR . PR Photo 18b/01 : The break-up of Comet LINEAR (false-colour). Comet LINEAR splits and brightens ESO PR Photo 18a/01 ESO PR Photo 18a/01 [Preview - JPEG: 400 x 438 pix - 55k] [Normal - JPEG: 800 x 875 pix - 136k] ESO PR Photo 18b/01 ESO PR Photo 18b/01 [Preview - JPEG: 367 x 400 pix - 112k] [Normal - JPEG: 734 x 800 pix - 272k] Caption : ESO PR Photo 18a/01 shows the three nuclei of Comet LINEAR (C/2001 A2). It is a reproduction of a 1-min exposure in red light, obtained in the early evening of May 16, 2001, with the 8.2-m VLT YEPUN (UT4) telescope at Paranal. ESO PR Photo 18b/01 shows the same image, but in a false-colour rendering for more clarity. The cometary fragment "B" (right) has split into "B1" and "B2" (separation about 1 arcsec, or 500 km) while fragment "A" (upper left) is considerably fainter. Technical information about these photos is available below. Comet LINEAR was discovered on January 3, 2001, and designated by the International Astronomical Union (IAU) as C/2001 A2 (see IAU Circular 7564 [1]). Six weeks ago, it was suddenly observed to brighten (IAUC 7605 [1]). Amateurs all over the world saw the comparatively faint comet reaching naked-eye magnitude and soon thereafter, observations with professional telescopes indicated

  18. Classifying Linear Canonical Relations

    OpenAIRE

    Lorand, Jonathan

    2015-01-01

    In this Master's thesis, we consider the problem of classifying, up to conjugation by linear symplectomorphisms, linear canonical relations (lagrangian correspondences) from a finite-dimensional symplectic vector space to itself. We give an elementary introduction to the theory of linear canonical relations and present partial results toward the classification problem. This exposition should be accessible to undergraduate students with a basic familiarity with linear algebra.

  19. Linear shaped charge

    Energy Technology Data Exchange (ETDEWEB)

    Peterson, David; Stofleth, Jerome H.; Saul, Venner W.

    2017-07-11

    Linear shaped charges are described herein. In a general embodiment, the linear shaped charge has an explosive with an elongated arrowhead-shaped profile. The linear shaped charge also has and an elongated v-shaped liner that is inset into a recess of the explosive. Another linear shaped charge includes an explosive that is shaped as a star-shaped prism. Liners are inset into crevices of the explosive, where the explosive acts as a tamper.

  20. On Regular Linear Relations

    Institute of Scientific and Technical Information of China (English)

    T. (A)LVAREZ

    2012-01-01

    For a closed linear relation in a Banach space the concept of regularity is introduced and studied.It is shown that many of the results of Mbekhta and other authors for operators remain valid in the context of multivalued linear operators.We also extend the punctured neighbourhood theorem for operators to linear relations and as an application we obtain a characterization of semiFredholm linear relations which are regular.

  1. Non-linear absorption of 1.3-μm wavelength femtosecond laser pulses focused inside semiconductors: Finite difference time domain-two temperature model combined computational study

    Science.gov (United States)

    Bogatyrev, I. B.; Grojo, D.; Delaporte, P.; Leyder, S.; Sentis, M.; Marine, W.; Itina, T. E.

    2011-11-01

    We present a theoretical model, which describes local energy deposition inside IR-transparent silicon and gallium arsenide with focused 1.3-μm wavelength femtosecond laser pulses. Our work relies on the ionization rate equation and two temperature model (TTM), as we simulate the non-linear propagation of focused femtosecond light pulses by using a 3D finite difference time domain method. We find a strong absorption dependence on the initial free electron density (doping concentration) that evidences the role of avalanche ionization. Despite an influence of Kerr-type self-focusing at intensity required for non-linear absorption, we show the laser energy deposition remains confined when the focus position is moved down to 1-mm below the surface. Our simulation results are in agreement with the degree of control observed in a simple model experiment.

  2. Comparison of QSAR models based on combinations of genetic algorithm, stepwise multiple linear regression, and artificial neural network methods to predict Kd of some derivatives of aromatic sulfonamides as carbonic anhydrase II inhibitors.

    Science.gov (United States)

    Maleki, Afshin; Daraei, Hiua; Alaei, Loghman; Faraji, Aram

    2014-01-01

    Four stepwise multiple linear regressions (SMLR) and a genetic algorithm (GA) based multiple linear regressions (MLR), together with artificial neural network (ANN) models, were applied for quantitative structure-activity relationship (QSAR) modeling of dissociation constants (Kd) of 62 arylsulfonamide (ArSA) derivatives as human carbonic anhydrase II (HCA II) inhibitors. The best subsets of molecular descriptors were selected by SMLR and GA-MLR methods. These selected variables were used to generate MLR and ANN models. The predictability power of models was examined by an external test set and cross validation. In addition, some tests were done to examine other aspects of the models. The results show that for certain purposes GA-MLR is better than SMLR and for others, ANN overcomes MLR models.

  3. Interpretability in Linear Brain Decoding

    OpenAIRE

    Kia, Seyed Mostafa; Passerini, Andrea

    2016-01-01

    Improving the interpretability of brain decoding approaches is of primary interest in many neuroimaging studies. Despite extensive studies of this type, at present, there is no formal definition for interpretability of brain decoding models. As a consequence, there is no quantitative measure for evaluating the interpretability of different brain decoding methods. In this paper, we present a simple definition for interpretability of linear brain decoding models. Then, we propose to combine the...

  4. Linear-Algebra Programs

    Science.gov (United States)

    Lawson, C. L.; Krogh, F. T.; Gold, S. S.; Kincaid, D. R.; Sullivan, J.; Williams, E.; Hanson, R. J.; Haskell, K.; Dongarra, J.; Moler, C. B.

    1982-01-01

    The Basic Linear Algebra Subprograms (BLAS) library is a collection of 38 FORTRAN-callable routines for performing basic operations of numerical linear algebra. BLAS library is portable and efficient source of basic operations for designers of programs involving linear algebriac computations. BLAS library is supplied in portable FORTRAN and Assembler code versions for IBM 370, UNIVAC 1100 and CDC 6000 series computers.

  5. Linear-Algebra Programs

    Science.gov (United States)

    Lawson, C. L.; Krogh, F. T.; Gold, S. S.; Kincaid, D. R.; Sullivan, J.; Williams, E.; Hanson, R. J.; Haskell, K.; Dongarra, J.; Moler, C. B.

    1982-01-01

    The Basic Linear Algebra Subprograms (BLAS) library is a collection of 38 FORTRAN-callable routines for performing basic operations of numerical linear algebra. BLAS library is portable and efficient source of basic operations for designers of programs involving linear algebriac computations. BLAS library is supplied in portable FORTRAN and Assembler code versions for IBM 370, UNIVAC 1100 and CDC 6000 series computers.

  6. The International Large Detector: Letter of Intent

    CERN Document Server

    Abe, Toshinori; Abramowicz, Halina; Adamus, Marek; Adeva, Bernardo; Afanaciev, Konstantin; Aguilar-Saavedra, Juan Antonio; Alabau Pons, Carmen; Albrecht, Hartwig; Andricek, Ladislav; Anduze, Marc; Aplin, Steve J.; Arai, Yasuo; Asano, Masaki; Attie, David; Attree, Derek J.; Burger, Jochen; Bailey, David; Balbuena, Juan Pablo; Ball, Markus; Ballin, James; Barbi, Mauricio; Barlow, Roger; Bartels, Christoph; Bartsch, Valeria; Bassignana, Daniela; Bates, Richard; Baudot, Jerome; Bechtle, Philip; Beck, Jeannine; Beckmann, Moritz; Bedjidian, Marc; Behnke, Ties; Belkadhi, Khaled; Bellerive, Alain; Bentvelsen, Stan; Bergauer, Thomas; Berggren, C.Mikael U.; Bergholz, Matthias; Bernreuther, Werner; Besancon, Marc; Besson, Auguste; Bhattacharya, Sudeb; Bhuyan, Bipul; Biebel, Otmar; Bilki, Burak; Blair, Grahame; Blumlein, Johannes; Bo, Li; Boisvert, Veronique; Bondar, A.; Bonvicini, Giovanni; Boos, Eduard; Boudry, Vincent; Bouquet, Bernard; Bouvier, Joel; Bozovic-Jelisavcic, Ivanka; Brient, Jean-Claude; Brock, Ian; Brogna, Andrea; Buchholz, Peter; Buesser, Karsten; Bulgheroni, Antonio; Butler, John; Buttar, Craig; Buzulutskov, A.F.; Caccia, Massimo; Caiazza, Stefano; Calcaterra, Alessandro; Caldwell, Allen; Callier, Stephane L.C.; Calvo Alamillo, Enrique; Campbell, Michael; Campbell, Alan J.; Cappellini, Chiara; Carloganu, Cristina; Castro, Nuno; Castro Carballo, Maria Elena; Chadeeva, Marina; Chakraborty, Dhiman; Chang, Paoti; Charpy, Alexandre; Chen, Xun; Chen, Shaomin; Chen, Hongfang; Cheon, Byunggu; Choi, Suyong; Choudhary, B.C.; Christen, Sandra; Ciborowski, Jacek; Ciobanu, Catalin; Claus, Gilles; Clerc, Catherine; Coca, Cornelia; Colas, Paul; Colijn, Auke; Colledani, Claude; Combaret, Christophe; Cornat, Remi; Cornebise, Patrick; Corriveau, Francois; Cvach, Jaroslav; Czakon, Michal; D'Ascenzo, Nicola; Da Silva, Wilfrid; Dadoun, Olivier; Dam, Mogens; Damerell, Chris; Danilov, Mikhail; Daniluk, Witold; Daubard, Guillaume; David, Dorte; David, Jacques; De Boer, Wim; De Groot, Nicolo; De Jong, Sijbrand; De Jong, Paul; De La Taille, Christophe; De Masi, Rita; De Roeck, Albert; Decotigny, David; Dehmelt, Klaus; Delagnes, Eric; Deng, Zhi; Desch, Klaus; Dieguez, Angel; Diener, Ralf; Dima, Mihai-Octavian; Dissertori, Gunther; Dixit, Madhu S.; Dolezal, Zdenek; Dolgoshein, Boris A.; Dollan, Ralph; Dorokhov, Andrei; Doublet, Philippe; Doyle, Tony; Doziere, Guy; Dragicevic, Marko; Drasal, Zbynek; Drugakov, Vladimir; Duarte Campderros, Jordi; Dulucq, Frederic; Dumitru, Laurentiu Alexandru; Dzahini, Daniel; Eberl, Helmut; Eckerlin, Guenter; Ehrenfeld, Wolfgang; Eigen, Gerald; Eklund, Lars; Elsen, Eckhard; Elsener, Konrad; Emeliantchik, Igor; Engels, Jan; Evrard, Christophe; Fabbri, Riccardo; Faber, Gerard; Faucci Giannelli, Michele; Faus-Golfe, Angeles; Feege, Nils; Feng, Cunfeng; Ferencei, Jozef; Fernandez Garcia, Marcos; Filthaut, Frank; Fleck, Ivor; Fleischer, Manfred; Fleta, Celeste; Fleury, Julien L.; Fontaine, Jean-Charles; Foster, Brian; Fourches, Nicolas; Fouz, Mary-Cruz; Frank, Sebastian; Frey, Ariane; Frotin, Mickael; Fujii, Hirofumi; Fujii, Keisuke; Fujimoto, Junpei; Fujita, Yowichi; Fusayasu, Takahiro; Fuster, Juan; Gaddi, Andrea; Gaede, Frank; Galkin, Alexei; Galkin, Valery; Gallas, Abraham; Gallin-Martel, Laurent; Gamba, Diego; Gao, Yuanning; Garrido Beltran, Lluis; Garutti, Erika; Gastaldi, Franck; Gaur, Bakul; Gay, Pascal; Gellrich, Andreas; Genat, Jean-Francois; Gentile, Simonetta; Gerwig, Hubert; Gibbons, Lawrence; Ginina, Elena; Giraud, Julien; Giraudo, Giuseppe; Gladilin, Leonid; Goldstein, Joel; Gonzalez Sanchez, Francisco Javier; Gournaris, Filimon; Greenshaw, Tim; Greenwood, Z.D.; Grefe, Christian; Gregor, Ingrid-Maria; Grenier, Gerald Jean; Gris, Philippe; Grondin, Denis; Grunewald, Martin; Grzelak, Grzegorz; Gurtu, Atul; Haas, Tobias; Haensel, Stephan; Hajdu, Csaba; Hallermann, Lea; Han, Liang; Hansen, Peter H.; Hara, Takanori; Harder, Kristian; Hartin, Anthony; Haruyama, Tomiyoshi; Harz, Martin; Hasegawa, Yoji; Hauschild, Michael; He, Qing; Hedberg, Vincent; Hedin, David; Heinze, Isa; Helebrant, Christian; Henschel, Hans; Hensel, Carsten; Hertenberger, Ralf; Herve, Alain; Higuchi, Takeo; Himmi, Abdelkader; Hironori, Kazurayama; Hlucha, Hana; Hommels, Bart; Horii, Yasuyuki; Horvath, Dezso; Hostachy, Jean-Yves; Hou, Wei-Shu; Hu-Guo, Christine; Huang, Xingtao; Huppert, Jean Francois; Ide, Yasuhiro; Idzik, Marek; Iglesias Escudero, Carmen; Ignatenko, Alexandr; Igonkina, Olga; Ikeda, Hirokazu; Ikematsu, Katsumasa; Ikemoto, Yukiko; Ikuno, Toshinori; Imbault, Didier; Imhof, Andreas; Imhoff, Marc; Ingbir, Ronen; Inoue, Eiji; Ioannis, Giomataris; Ishikawa, Akimasa; Itagaki, Kennosuke; Ito, Kazutoshi; Itoh, Hideo; Iwabuchi, Masaya; Iwai, Go; Iwamoto, Toshiyuki; Jacosalem, Editha P.; Jaramillo Echeverria, Richard; Jeans, Daniel T D.; Jing, Fanfan; Jing, Ge; Jokic, Stevan; Jonsson, Leif; Jore, Matthieu; Jovin, Tatjana; Kafer, Daniela; Kajino, Fumiyoshi; Kamai, Yusuke; Kaminski, Jochen; Kamiya, Yoshio; Kaplan, Alexander; Kapusta, Frederic; Kar, Deepak; Karlen, Dean; Katayama, Nobu; Kato, Eriko; Kato, Yukihiro; Kaukher, Alexander; Kawagoe, Kiyotomo; Kawahara, Hiroki; Kawai, Masanori; Kawasaki, Takeo; Khan, Sameen Ahmed; Kieffer, Robert; Kielar, Eryk; Kiesenhofer, Wolfgang; Kiesling, Christian M.; Killenberg, Martin; Kim, Donghee; Kim, Choong Sun; Kim, Guinyun; Kim, Hong Joo; Kim, Eun-Joo; Kim, Hyunok; Kim, Shinhong; Kircher, Francois; Kisielewska, Danuta; Kleinwort, Claus; Klimkovich, Tatsiana; Kluge, Hanna; Kluit, Peter Martin; Kobayashi, Makoto; Kobel, Michael; Kodama, Hideyo; Kodys, Peter; Koetz, U.; Koffeman, Els; Kohriki, Takashi; Komamiya, Sachio; Kondou, Yoshinari; Korbel, Volker; Kotera, Katsushige; Krucker, Dirk; Kraml, Sabine; Krammer, Manfred; Krastev, Kaloyan; Krause, Bernward; Krautscheid, Thorsten; Kschioneck, Kirsten; Kuang, Yu-Ping; Kuhlmann, Jan; Kuroiwa, Hirotoshi; Kusano, Tomonori; Kvasnicka, Peter; Lacasta Llacer, Carlos; Lagorio, Eric; Laktineh, Imad; Lange, Wolfgang; Lebrun, Patrice; Lee, Jik; Lehner, Frank; Lesiak, Tadeusz; Levy, Aharon; Li, Bo; Li, Ting; Li, Yulan; Li, Hengne; Liang, Zuotang; Lima, Guilherme; Linde, Frank; Linssen, Lucie; Linzmaier, Diana; List, Benno; List, Jenny; Liu, Bo; Llopart Cudie, Xavier; Lohmann, Wolfgang; Lopez Virto, Amparo; Lozano, Manuel; Lu, Shaojun; Lucaci-Timoce, Angela Isabela; Lumb, Nick; Lundberg, Bjorn; Lutz, Pierre; Lutz, Benjamin; Lux, Thorsten; Luzniak, Pawel; Lyapin, Alexey; Ma, Wengan; Maczewski, Lukasz; Mader, Wolfgang F.; Maity, Manas; Majumdar, Nayana; Majumder, Gobinda; Maki, Akihiro; Makida, Yasuhiro; Mamuzic, Judita; Marc, Dhellot; Marchesini, Ivan; Marcisovsky, Michal; Marias, Carlos; Marshall, John; Martens, Cornelius; Martin, Victoria J.; Martin, Jean-Pierre; Martin-Chassard, Gisele; Martinez Rivero, Celso; Martyn, Hans-Ulrich; Mathez, Herve; Mathieu, Antoine; Matsuda, Takeshi; Matsunaga, Hiroyuki; Matsushita, Takashi; Mavromanolakis, Georgios; Mcdonald, Kirk T.; Mereu, Paolo; Merk, Marcel; Merkin, Mikhail M.; Meyer, Niels; Meyners, Norbert; Mihara, Satoshi; Miller, David J.; Miller, Owen; Mitaroff, Winfried A.; Miyamoto, Akiya; Miyata, Hitoshi; Mjornmark, Ulf; Mnich, Joachim; Monig, Klaus; Moll, Andreas; Moortgat-Pick, Gudrid A.; Mora De Freitas, Paulo; Morel, Frederic; Moretti, Stefano; Morgunov, Vasily; Mori, Toshinori; Mori, Takashi; Morin, Laurent; Morozov, Sergey; Moser, Hans-Gunther; Moser, Fabian; Moya, David; Mudrinic, Mihajlo; Mukhopadhyay, Supratik; Murakami, Takeshi; Musa, Luciano; Musat, Gabriel; Nagamine, Tadashi; Nakamura, Isamu; Nakano, Eiichi; Nakashima, Kenichi; Nakayoshi, Kazuo; Nakazawa, Hideyuki; Nam, Shinwoo; Nam, Jiwoo; Nemecek, Stanislav; Niebuhr, Carsten; Niechciol, Marcus; Niezurawski, Piotr; Nishida, Shohei; Nishiyama, Miho; Nitoh, Osamu; Norbeck, Ed; Nozaki, Mitsuaki; O'Shea, Val; Ohlerich, Martin; Okada, Nobuchika; Olchevski, Alexander; Olivier, Bob; Oliwa, Krzysztof; Omori, Tsunehiko; Onel, Yasar; Ono, Hiroaki; Ono, Yoshimasa; Onuki, Yoshiyuki; Ootani, Wataru; Orava, Risto; Orlandea, Marius Ciprian; Oskarsson, Anders; Osland, Per; Ossetski, Dmitri; Osterman, Lennart; Padilla, Cristobal; Pandurovic, Mila; Park, Il Hung; Park, Hwanbae; Parkes, Chris; Patrick, Ghislain; Patterson, J.Ritchie; Pawlik, Bogdan; Pellegrini, Giulio; Pellegrino, Antonio; Peterson, Daniel; Petrov, Alexander; Pham, Thanh Hung; Piccolo, Marcello; Poeschl, Roman; Polak, Ivo; Popova, Elena; Postranecky, Martin; Prahl, Volker; Prudent, Xavier; Przysiezniak, Helenka; Puerta-Pelayo, Jesus; Qian, Wenbin; Quadt, Arnulf; Rarbi, Fatah-Ellah; Raspereza, Alexei; Ratti, Lodovico; Raux, Ludovic; Raven, Gerhard; Re, Valerio; Regler, Meinhard; Reinhard, Marcel; Renz, Uwe; Repain, Philippe; Repond, Jose; Richard, Francois; Riemann, Sabine; Riemann, Tord; Riera-Babures, Jordi; Riu, Imma; Robert, Kieffer; Robson, Aidan; Roloff, Philipp; Rosca, Aura; Rosemann, Christoph; Rosiek, Janusz; Rossmanith, Robert; Roth, Stefan; Royon, Christophe; Ruan, Manqi; Ruiz-Jimeno, Alberto; Rusinov, Vladimir; Ruzicka, Pavel; Ryzhikov, Dmitri; Saborido, Juan J.; Sadeh, Iftach; Sailer, Andre; Saito, Masatoshi; Sakuma, Takayuki; Sanami, Toshiya; Sanuki, Tomoyuki; Sarkar, Sandip; Sasaki, Rei; Sato, Yutaro; Saveliev, Valeri; Savoy-Navarro, Aurore; Sawyer, Lee; Schafer, Oliver; Schalicke, Andreas; Schuler, K.Peter; Schade, Peter; Schaffran, Joern; Scheirich, Jan; Schlatter, Dieter; Schmidt, Ringo Sebastian; Schmitt, Sebastian; Schneekloth, Uwe; Schreiber, Heinz Juergen; Schultz-Coulon, Hans-Christian; Schumacher, Markus; Schumm, Bruce A.; Schuwalow, Sergej; Schwierz, Rainer; Sefkow, Felix; Sefri, Rachid; Seguin-Moreau, Nathalie; Seidel, Katja; Sekaric, Jadranka; Sendai, Hiroshi; Settles, Ronald Dean; Shao, Ming; Shechtman, L.I.; Shimazaki, Shoichi; Shumeiko, Nikolai; Sicho, Petr; Simon, Frank; Sinram, Klaus; Smiljanic, Ivan; Smiljkovic, Nebojsa; Smolik, Jan; Sobloher, Blanka; Soldner, Christian; Song, Kezhu; Sopczak, Andre; Speckmayer, Peter; Stenlund, Evert; Stockinger, Dominik; Stoeck, Holger; Strohmer, Raimund; Straessner, Arno; Stromhagen, Richard; Sudo, Yuji; Suehara, Taikan; Suekane, Fumihiko; Suetsugu, Yusuke; Sugimoto, Yasuhiro; Sugiyama, Akira; Sumisawa, Kazutaka; Suzuki, Shiro; Swientek, Krzysztof; Tabassam, Hajrah; Takahashi, Tohru; Takeda, Hiroshi; Takeshita, Tohru; Takubo, Yosuke; Tanabe, Tomohiko; Tanaka, Shuji; Tanaka, Ken-Ichi; Tanaka, Manobu; Tapprogge, Stefan; Tarkovsky, Evgueny I.; Tauchi, Toshiaki; Tauchi, Kazuya; Telnov, Valery I.; Teodorescu, Eliza; Thomson, Mark; Tian, Junping; Timmermans, Jan; Titov, Maxim P.; Tokushuku, Katsuo; Tozuka, Shunsuke; Tsuboyama, Toru; Ueno, Koji; Ullan, Miguel; Uozumi, Satoru; Urakawa, Junji; Ushakov, Andriy; Ushiroda, Yutaka; Valentan, Manfred; Valin, Isabelle; Van Der Graaf, Harry; Van Doren, Brian; Van Kooten, Rick J.; Vander Donckt, Muriel; Vanel, Jean-Charles; Vazquez Regueiro, Pablo; Verzocchi, Marco; Vescovi, Christophe; Videau, Henri L.; Vila, Ivan; Vilasis-Cardona, Xavier; Vogel, Adrian; Volkenborn, Robert; Vos, Marcel; Voutsinas, Yorgos; Vrba, Vaclav; Vreeswijk, Marcel; Walsh, Roberval; Waltenberger, Wolfgang; Wang, Min-Zu; Wang, Yi; Wang, Xiaoliang; Wang, Qun; Wang, Meng; Ward, David R.; Warren, Matthew; Watanabe, Minori; Watanabe, Takashi; Watson, Nigel K.; Wattimena, Nanda; Wendt, Oliver; Wermes, Norbert; Weuste, Lars; Wichmann, Katarzyna; Wienemann, Peter; Wierba, Wojciech; Wilson, Graham W.; Wilson, John A.; Wing, Matthew; Winter, Marc; Wobisch, Markus; Worek, Malgorzata; Xella, Stefania; Xu, Zizong; Yamaguchi, Akira; Yamaguchi, Hiroshi; Yamamoto, Hitoshi; Yamaoka, Hiroshi; Yamashita, Satoru; Yamauchi, M.; Yamazaki, Yuji; Yamouni, Mahfoud; Yan, Wenbiao; Yanagida, Koji; Yang, Haijun; Yang, Jongmann; Yang, Jin Min; Yang, Zhenwei; Yasu, Yoshiji; Yonamine, Ryo; Yoshida, Kohei; Yoshida, Takuo; Yoshioka, Tamaki; Yu, Chunxu; Yu, Intae; Yue, Qian; Zacek, Josef; Zalesak, Jaroslav; Zarnecki, Aleksander Filip; Zawiejski, Leszek; Zeitnitz, Christian; Zerwas, Dirk; Zeuner, Wolfram; Zhang, Yanxi; Zhang, Ziping; Zhang, Renyou; Zhang, Xueyao; Zhang, Zhiqing; Zhao, Jiawei; Zhao, Zhengguo; Zheng, Baojun; Zhong, Liang; Zhou, Yongzhao; Zhu, Xianglei; Zhu, Chengguang; Zomer, Fabian; Zutshi, Vishnu

    2010-01-01

    The International Large Detector (ILD) is a concept for a detector at the International Linear Collider, ILC. The ILC will collide electrons and positrons at energies of initially 500 GeV, upgradeable to 1 TeV. The ILC has an ambitious physics program, which will extend and complement that of the Large Hadron Collider (LHC). A hallmark of physics at the ILC is precision. The clean initial state and the comparatively benign environment of a lepton collider are ideally suited to high precision measurements. To take full advantage of the physics potential of ILC places great demands on the detector performance. The design of ILD is driven by these requirements. Excellent calorimetry and tracking are combined to obtain the best possible overall event reconstruction, including the capability to reconstruct individual particles within jets for particle ow calorimetry. This requires excellent spatial resolution for all detector systems. A highly granular calorimeter system is combined with a central tracker which st...

  7. The International Large Detector: Letter of Intent

    CERN Document Server

    Abe, Toshinori; Abramowicz, Halina; Adamus, Marek; Adeva, Bernardo; Afanaciev, Konstantin; Aguilar-Saavedra, Juan Antonio; Alabau Pons, Carmen; Albrecht, Hartwig; Andricek, Ladislav; Anduze, Marc; Aplin, Steve J.; Arai, Yasuo; Asano, Masaki; Attie, David; Attree, Derek J.; Burger, Jochen; Bailey, David; Balbuena, Juan Pablo; Ball, Markus; Ballin, James; Barbi, Mauricio; Barlow, Roger; Bartels, Christoph; Bartsch, Valeria; Bassignana, Daniela; Bates, Richard; Baudot, Jerome; Bechtle, Philip; Beck, Jeannine; Beckmann, Moritz; Bedjidian, Marc; Behnke, Ties; Belkadhi, Khaled; Bellerive, Alain; Bentvelsen, Stan; Bergauer, Thomas; Berggren, C.Mikael U.; Bergholz, Matthias; Bernreuther, Werner; Besancon, Marc; Besson, Auguste; Bhattacharya, Sudeb; Bhuyan, Bipul; Biebel, Otmar; Bilki, Burak; Blair, Grahame; Blumlein, Johannes; Bo, Li; Boisvert, Veronique; Bondar, A.; Bonvicini, Giovanni; Boos, Eduard; Boudry, Vincent; Bouquet, Bernard; Bouvier, Joel; Bozovic-Jelisavcic, Ivanka; Brient, Jean-Claude; Brock, Ian; Brogna, Andrea; Buchholz, Peter; Buesser, Karsten; Bulgheroni, Antonio; Butler, John; Buttar, Craig; Buzulutskov, A.F.; Caccia, Massimo; Caiazza, Stefano; Calcaterra, Alessandro; Caldwell, Allen; Callier, Stephane L.C.; Calvo Alamillo, Enrique; Campbell, Michael; Campbell, Alan J.; Cappellini, Chiara; Carloganu, Cristina; Castro, Nuno; Castro Carballo, Maria Elena; Chadeeva, Marina; Chakraborty, Dhiman; Chang, Paoti; Charpy, Alexandre; Chen, Xun; Chen, Shaomin; Chen, Hongfang; Cheon, Byunggu; Choi, Suyong; Choudhary, B.C.; Christen, Sandra; Ciborowski, Jacek; Ciobanu, Catalin; Claus, Gilles; Clerc, Catherine; Coca, Cornelia; Colas, Paul; Colijn, Auke; Colledani, Claude; Combaret, Christophe; Cornat, Remi; Cornebise, Patrick; Corriveau, Francois; Cvach, Jaroslav; Czakon, Michal; D'Ascenzo, Nicola; Da Silva, Wilfrid; Dadoun, Olivier; Dam, Mogens; Damerell, Chris; Danilov, Mikhail; Daniluk, Witold; Daubard, Guillaume; David, Dorte; David, Jacques; De Boer, Wim; De Groot, Nicolo; De Jong, Sijbrand; De Jong, Paul; De La Taille, Christophe; De Masi, Rita; De Roeck, Albert; Decotigny, David; Dehmelt, Klaus; Delagnes, Eric; Deng, Zhi; Desch, Klaus; Dieguez, Angel; Diener, Ralf; Dima, Mihai-Octavian; Dissertori, Gunther; Dixit, Madhu S.; Dolezal, Zdenek; Dolgoshein, Boris A.; Dollan, Ralph; Dorokhov, Andrei; Doublet, Philippe; Doyle, Tony; Doziere, Guy; Dragicevic, Marko; Drasal, Zbynek; Drugakov, Vladimir; Duarte Campderros, Jordi; Dulucq, Frederic; Dumitru, Laurentiu Alexandru; Dzahini, Daniel; Eberl, Helmut; Eckerlin, Guenter; Ehrenfeld, Wolfgang; Eigen, Gerald; Eklund, Lars; Elsen, Eckhard; Elsener, Konrad; Emeliantchik, Igor; Engels, Jan; Evrard, Christophe; Fabbri, Riccardo; Faber, Gerard; Faucci Giannelli, Michele; Faus-Golfe, Angeles; Feege, Nils; Feng, Cunfeng; Ferencei, Jozef; Fernandez Garcia, Marcos; Filthaut, Frank; Fleck, Ivor; Fleischer, Manfred; Fleta, Celeste; Fleury, Julien L.; Fontaine, Jean-Charles; Foster, Brian; Fourches, Nicolas; Fouz, Mary-Cruz; Frank, Sebastian; Frey, Ariane; Frotin, Mickael; Fujii, Hirofumi; Fujii, Keisuke; Fujimoto, Junpei; Fujita, Yowichi; Fusayasu, Takahiro; Fuster, Juan; Gaddi, Andrea; Gaede, Frank; Galkin, Alexei; Galkin, Valery; Gallas, Abraham; Gallin-Martel, Laurent; Gamba, Diego; Gao, Yuanning; Garrido Beltran, Lluis; Garutti, Erika; Gastaldi, Franck; Gaur, Bakul; Gay, Pascal; Gellrich, Andreas; Genat, Jean-Francois; Gentile, Simonetta; Gerwig, Hubert; Gibbons, Lawrence; Ginina, Elena; Giraud, Julien; Giraudo, Giuseppe; Gladilin, Leonid; Goldstein, Joel; Gonzalez Sanchez, Francisco Javier; Gournaris, Filimon; Greenshaw, Tim; Greenwood, Z.D.; Grefe, Christian; Gregor, Ingrid-Maria; Grenier, Gerald Jean; Gris, Philippe; Grondin, Denis; Grunewald, Martin; Grzelak, Grzegorz; Gurtu, Atul; Haas, Tobias; Haensel, Stephan; Hajdu, Csaba; Hallermann, Lea; Han, Liang; Hansen, Peter H.; Hara, Takanori; Harder, Kristian; Hartin, Anthony; Haruyama, Tomiyoshi; Harz, Martin; Hasegawa, Yoji; Hauschild, Michael; He, Qing; Hedberg, Vincent; Hedin, David; Heinze, Isa; Helebrant, Christian; Henschel, Hans; Hensel, Carsten; Hertenberger, Ralf; Herve, Alain; Higuchi, Takeo; Himmi, Abdelkader; Hironori, Kazurayama; Hlucha, Hana; Hommels, Bart; Horii, Yasuyuki; Horvath, Dezso; Hostachy, Jean-Yves; Hou, Wei-Shu; Hu-Guo, Christine; Huang, Xingtao; Huppert, Jean Francois; Ide, Yasuhiro; Idzik, Marek; Iglesias Escudero, Carmen; Ignatenko, Alexandr; Igonkina, Olga; Ikeda, Hirokazu; Ikematsu, Katsumasa; Ikemoto, Yukiko; Ikuno, Toshinori; Imbault, Didier; Imhof, Andreas; Imhoff, Marc; Ingbir, Ronen; Inoue, Eiji; Ioannis, Giomataris; Ishikawa, Akimasa; Itagaki, Kennosuke; Ito, Kazutoshi; Itoh, Hideo; Iwabuchi, Masaya; Iwai, Go; Iwamoto, Toshiyuki; Jacosalem, Editha P.; Jaramillo Echeverria, Richard; Jeans, Daniel T D.; Jing, Fanfan; Jing, Ge; Jokic, Stevan; Jonsson, Leif; Jore, Matthieu; Jovin, Tatjana; Kafer, Daniela; Kajino, Fumiyoshi; Kamai, Yusuke; Kaminski, Jochen; Kamiya, Yoshio; Kaplan, Alexander; Kapusta, Frederic; Kar, Deepak; Karlen, Dean; Katayama, Nobu; Kato, Eriko; Kato, Yukihiro; Kaukher, Alexander; Kawagoe, Kiyotomo; Kawahara, Hiroki; Kawai, Masanori; Kawasaki, Takeo; Khan, Sameen Ahmed; Kieffer, Robert; Kielar, Eryk; Kiesenhofer, Wolfgang; Kiesling, Christian M.; Killenberg, Martin; Kim, Donghee; Kim, Choong Sun; Kim, Guinyun; Kim, Hong Joo; Kim, Eun-Joo; Kim, Hyunok; Kim, Shinhong; Kircher, Francois; Kisielewska, Danuta; Kleinwort, Claus; Klimkovich, Tatsiana; Kluge, Hanna; Kluit, Peter Martin; Kobayashi, Makoto; Kobel, Michael; Kodama, Hideyo; Kodys, Peter; Koetz, U.; Koffeman, Els; Kohriki, Takashi; Komamiya, Sachio; Kondou, Yoshinari; Korbel, Volker; Kotera, Katsushige; Krucker, Dirk; Kraml, Sabine; Krammer, Manfred; Krastev, Kaloyan; Krause, Bernward; Krautscheid, Thorsten; Kschioneck, Kirsten; Kuang, Yu-Ping; Kuhlmann, Jan; Kuroiwa, Hirotoshi; Kusano, Tomonori; Kvasnicka, Peter; Lacasta Llacer, Carlos; Lagorio, Eric; Laktineh, Imad; Lange, Wolfgang; Lebrun, Patrice; Lee, Jik; Lehner, Frank; Lesiak, Tadeusz; Levy, Aharon; Li, Bo; Li, Ting; Li, Yulan; Li, Hengne; Liang, Zuotang; Lima, Guilherme; Linde, Frank; Linssen, Lucie; Linzmaier, Diana; List, Benno; List, Jenny; Liu, Bo; Llopart Cudie, Xavier; Lohmann, Wolfgang; Lopez Virto, Amparo; Lozano, Manuel; Lu, Shaojun; Lucaci-Timoce, Angela Isabela; Lumb, Nick; Lundberg, Bjorn; Lutz, Pierre; Lutz, Benjamin; Lux, Thorsten; Luzniak, Pawel; Lyapin, Alexey; Ma, Wengan; Maczewski, Lukasz; Mader, Wolfgang F.; Maity, Manas; Majumdar, Nayana; Majumder, Gobinda; Maki, Akihiro; Makida, Yasuhiro; Mamuzic, Judita; Marc, Dhellot; Marchesini, Ivan; Marcisovsky, Michal; Marias, Carlos; Marshall, John; Martens, Cornelius; Martin, Victoria J.; Martin, Jean-Pierre; Martin-Chassard, Gisele; Martinez Rivero, Celso; Martyn, Hans-Ulrich; Mathez, Herve; Mathieu, Antoine; Matsuda, Takeshi; Matsunaga, Hiroyuki; Matsushita, Takashi; Mavromanolakis, Georgios; Mcdonald, Kirk T.; Mereu, Paolo; Merk, Marcel; Merkin, Mikhail M.; Meyer, Niels; Meyners, Norbert; Mihara, Satoshi; Miller, David J.; Miller, Owen; Mitaroff, Winfried A.; Miyamoto, Akiya; Miyata, Hitoshi; Mjornmark, Ulf; Mnich, Joachim; Monig, Klaus; Moll, Andreas; Moortgat-Pick, Gudrid A.; Mora De Freitas, Paulo; Morel, Frederic; Moretti, Stefano; Morgunov, Vasily; Mori, Toshinori; Mori, Takashi; Morin, Laurent; Morozov, Sergey; Moser, Hans-Gunther; Moser, Fabian; Moya, David; Mudrinic, Mihajlo; Mukhopadhyay, Supratik; Murakami, Takeshi; Musa, Luciano; Musat, Gabriel; Nagamine, Tadashi; Nakamura, Isamu; Nakano, Eiichi; Nakashima, Kenichi; Nakayoshi, Kazuo; Nakazawa, Hideyuki; Nam, Shinwoo; Nam, Jiwoo; Nemecek, Stanislav; Niebuhr, Carsten; Niechciol, Marcus; Niezurawski, Piotr; Nishida, Shohei; Nishiyama, Miho; Nitoh, Osamu; Norbeck, Ed; Nozaki, Mitsuaki; O'Shea, Val; Ohlerich, Martin; Okada, Nobuchika; Olchevski, Alexander; Olivier, Bob; Oliwa, Krzysztof; Omori, Tsunehiko; Onel, Yasar; Ono, Hiroaki; Ono, Yoshimasa; Onuki, Yoshiyuki; Ootani, Wataru; Orava, Risto; Orlandea, Marius Ciprian; Oskarsson, Anders; Osland, Per; Ossetski, Dmitri; Osterman, Lennart; Padilla, Cristobal; Pandurovic, Mila; Park, Il Hung; Park, Hwanbae; Parkes, Chris; Patrick, Ghislain; Patterson, J.Ritchie; Pawlik, Bogdan; Pellegrini, Giulio; Pellegrino, Antonio; Peterson, Daniel; Petrov, Alexander; Pham, Thanh Hung; Piccolo, Marcello; Poeschl, Roman; Polak, Ivo; Popova, Elena; Postranecky, Martin; Prahl, Volker; Prudent, Xavier; Przysiezniak, Helenka; Puerta-Pelayo, Jesus; Qian, Wenbin; Quadt, Arnulf; Rarbi, Fatah-Ellah; Raspereza, Alexei; Ratti, Lodovico; Raux, Ludovic; Raven, Gerhard; Re, Valerio; Regler, Meinhard; Reinhard, Marcel; Renz, Uwe; Repain, Philippe; Repond, Jose; Richard, Francois; Riemann, Sabine; Riemann, Tord; Riera-Babures, Jordi; Riu, Imma; Robert, Kieffer; Robson, Aidan; Roloff, Philipp; Rosca, Aura; Rosemann, Christoph; Rosiek, Janusz; Rossmanith, Robert; Roth, Stefan; Royon, Christophe; Ruan, Manqi; Ruiz-Jimeno, Alberto; Rusinov, Vladimir; Ruzicka, Pavel; Ryzhikov, Dmitri; Saborido, Juan J.; Sadeh, Iftach; Sailer, Andre; Saito, Masatoshi; Sakuma, Takayuki; Sanami, Toshiya; Sanuki, Tomoyuki; Sarkar, Sandip; Sasaki, Rei; Sato, Yutaro; Saveliev, Valeri; Savoy-Navarro, Aurore; Sawyer, Lee; Schafer, Oliver; Schalicke, Andreas; Schuler, K.Peter; Schade, Peter; Schaffran, Joern; Scheirich, Jan; Schlatter, Dieter; Schmidt, Ringo Sebastian; Schmitt, Sebastian; Schneekloth, Uwe; Schreiber, Heinz Juergen; Schultz-Coulon, Hans-Christian; Schumacher, Markus; Schumm, Bruce A.; Schuwalow, Sergej; Schwierz, Rainer; Sefkow, Felix; Sefri, Rachid; Seguin-Moreau, Nathalie; Seidel, Katja; Sekaric, Jadranka; Sendai, Hiroshi; Settles, Ronald Dean; Shao, Ming; Shechtman, L.I.; Shimazaki, Shoichi; Shumeiko, Nikolai; Sicho, Petr; Simon, Frank; Sinram, Klaus; Smiljanic, Ivan; Smiljkovic, Nebojsa; Smolik, Jan; Sobloher, Blanka; Soldner, Christian; Song, Kezhu; Sopczak, Andre; Speckmayer, Peter; Stenlund, Evert; Stockinger, Dominik; Stoeck, Holger; Strohmer, Raimund; Straessner, Arno; Stromhagen, Richard; Sudo, Yuji; Suehara, Taikan; Suekane, Fumihiko; Suetsugu, Yusuke; Sugimoto, Yasuhiro; Sugiyama, Akira; Sumisawa, Kazutaka; Suzuki, Shiro; Swientek, Krzysztof; Tabassam, Hajrah; Takahashi, Tohru; Takeda, Hiroshi; Takeshita, Tohru; Takubo, Yosuke; Tanabe, Tomohiko; Tanaka, Shuji; Tanaka, Ken-Ichi; Tanaka, Manobu; Tapprogge, Stefan; Tarkovsky, Evgueny I.; Tauchi, Toshiaki; Tauchi, Kazuya; Telnov, Valery I.; Teodorescu, Eliza; Thomson, Mark; Tian, Junping; Timmermans, Jan; Titov, Maxim P.; Tokushuku, Katsuo; Tozuka, Shunsuke; Tsuboyama, Toru; Ueno, Koji; Ullan, Miguel; Uozumi, Satoru; Urakawa, Junji; Ushakov, Andriy; Ushiroda, Yutaka; Valentan, Manfred; Valin, Isabelle; Van Der Graaf, Harry; Van Doren, Brian; Van Kooten, Rick J.; Vander Donckt, Muriel; Vanel, Jean-Charles; Vazquez Regueiro, Pablo; Verzocchi, Marco; Vescovi, Christophe; Videau, Henri L.; Vila, Ivan; Vilasis-Cardona, Xavier; Vogel, Adrian; Volkenborn, Robert; Vos, Marcel; Voutsinas, Yorgos; Vrba, Vaclav; Vreeswijk, Marcel; Walsh, Roberval; Waltenberger, Wolfgang; Wang, Min-Zu; Wang, Yi; Wang, Xiaoliang; Wang, Qun; Wang, Meng; Ward, David R.; Warren, Matthew; Watanabe, Minori; Watanabe, Takashi; Watson, Nigel K.; Wattimena, Nanda; Wendt, Oliver; Wermes, Norbert; Weuste, Lars; Wichmann, Katarzyna; Wienemann, Peter; Wierba, Wojciech; Wilson, Graham W.; Wilson, John A.; Wing, Matthew; Winter, Marc; Wobisch, Markus; Worek, Malgorzata; Xella, Stefania; Xu, Zizong; Yamaguchi, Akira; Yamaguchi, Hiroshi; Yamamoto, Hitoshi; Yamaoka, Hiroshi; Yamashita, Satoru; Yamauchi, M.; Yamazaki, Yuji; Yamouni, Mahfoud; Yan, Wenbiao; Yanagida, Koji; Yang, Haijun; Yang, Jongmann; Yang, Jin Min; Yang, Zhenwei; Yasu, Yoshiji; Yonamine, Ryo; Yoshida, Kohei; Yoshida, Takuo; Yoshioka, Tamaki; Yu, Chunxu; Yu, Intae; Yue, Qian; Zacek, Josef; Zalesak, Jaroslav; Zarnecki, Aleksander Filip; Zawiejski, Leszek; Zeitnitz, Christian; Zerwas, Dirk; Zeuner, Wolfram; Zhang, Yanxi; Zhang, Ziping; Zhang, Renyou; Zhang, Xueyao; Zhang, Zhiqing; Zhao, Jiawei; Zhao, Zhengguo; Zheng, Baojun; Zhong, Liang; Zhou, Yongzhao; Zhu, Xianglei; Zhu, Chengguang; Zomer, Fabian; Zutshi, Vishnu

    2010-01-01

    The International Large Detector (ILD) is a concept for a detector at the International Linear Collider, ILC. The ILC will collide electrons and positrons at energies of initially 500 GeV, upgradeable to 1 TeV. The ILC has an ambitious physics program, which will extend and complement that of the Large Hadron Collider (LHC). A hallmark of physics at the ILC is precision. The clean initial state and the comparatively benign environment of a lepton collider are ideally suited to high precision measurements. To take full advantage of the physics potential of ILC places great demands on the detector performance. The design of ILD is driven by these requirements. Excellent calorimetry and tracking are combined to obtain the best possible overall event reconstruction, including the capability to reconstruct individual particles within jets for particle ow calorimetry. This requires excellent spatial resolution for all detector systems. A highly granular calorimeter system is combined with a central tracker which st...

  8. Analysis of Combined Power and Refrigeration Generation Using the Carbon Dioxide Thermodynamic Cycle to Recover the Waste Heat of an Internal Combustion Engine

    Directory of Open Access Journals (Sweden)

    Shunsen Wang

    2014-01-01

    Full Text Available A novel thermodynamic system is proposed to recover the waste heat of an internal combustion engine (ICE by integrating the transcritical carbon dioxide (CO2 refrigeration cycle with the supercritical CO2 power cycle, and eight kinds of integration schemes are developed. The key parameters of the system are optimized through a genetic algorithm to achieve optimum matching with different variables and schemes, as well as the maximum net power output (Wnet. The results indicate that replacing a single-turbine scheme with a double-turbine scheme can significantly enhance the net power output (Wnet and lower the inlet pressure of the power turbine (P4. With the same exhaust parameters of ICE, the maximum Wnet of the double-turbines scheme is 40%–50% higher than that of the single-turbine scheme. Replacing a single-stage compression scheme with a double-stage compression scheme can also lower the value of P4, while it could not always significantly enhance the value of Wnet. Except for the power consumption of air conditioning, the net power output of this thermodynamic system can reach up to 13%–35% of the engine power when it is used to recover the exhaust heat of internal combustion engines.

  9. Permafrost Hazards and Linear Infrastructure

    Science.gov (United States)

    Stanilovskaya, Julia; Sergeev, Dmitry

    2014-05-01

    The international experience of linear infrastructure planning, construction and exploitation in permafrost zone is being directly tied to the permafrost hazard assessment. That procedure should also consider the factors of climate impact and infrastructure protection. The current global climate change hotspots are currently polar and mountain areas. Temperature rise, precipitation and land ice conditions change, early springs occur more often. The big linear infrastructure objects cross the territories with different permafrost conditions which are sensitive to the changes in air temperature, hydrology, and snow accumulation which are connected to climatic dynamics. One of the most extensive linear structures built on permafrost worldwide are Trans Alaskan Pipeline (USA), Alaska Highway (Canada), Qinghai-Xizang Railway (China) and Eastern Siberia - Pacific Ocean Oil Pipeline (Russia). Those are currently being influenced by the regional climate change and permafrost impact which may act differently from place to place. Thermokarst is deemed to be the most dangerous process for linear engineering structures. Its formation and development depend on the linear structure type: road or pipeline, elevated or buried one. Zonal climate and geocryological conditions are also of the determining importance here. All the projects are of the different age and some of them were implemented under different climatic conditions. The effects of permafrost thawing have been recorded every year since then. The exploration and transportation companies from different countries maintain the linear infrastructure from permafrost degradation in different ways. The highways in Alaska are in a good condition due to governmental expenses on annual reconstructions. The Chara-China Railroad in Russia is under non-standard condition due to intensive permafrost response. Standards for engineering and construction should be reviewed and updated to account for permafrost hazards caused by the

  10. Non-heparinized ECMO serves a rescue method in a multitrauma patient combining pulmonary contusion and nonoperative internal bleeding: a case report and literature review.

    Science.gov (United States)

    Wen, Pei-Hung; Chan, Wai Hung; Chen, Ying-Cheng; Chen, Yao-Li; Chan, Chien-Pin; Lin, Ping-Yi

    2015-01-01

    Pulmonary contusion and acute respiratory distress syndrome (ARDS) is a common manifestation in polytraumatic patients. Although mechanical ventilation is still the first choice of treatment, a group of patients are still unable to maintain their oxygenation. The role of extracorporeal membrane oxygenation (ECMO) has been more clarified when the lung is extensively damaged and when conventional modality failed. ECMO provides the lung an opportunity to rest by permitting reduced ventilator settings and limiting further barotraumas. However, ECMO is still considered contraindicated in polytramatic patients combining pulmonary contusion and other organ hemorrhage because of systemic anticoagulation during the treatment. We herein report a patient who successfully survive a multitrauma combining pulmonary contusion and grade IV liver laceration using non-heparinized venovenous extracorporeal membrane oxygenation (vv-ECMO). The associated literature were reviewed.

  11. Advanced linear algebra

    CERN Document Server

    Cooperstein, Bruce

    2010-01-01

    Vector SpacesFieldsThe Space FnVector Spaces over an Arbitrary Field Subspaces of Vector SpacesSpan and IndependenceBases and Finite Dimensional Vector SpacesBases and Infinite Dimensional Vector SpacesCoordinate VectorsLinear TransformationsIntroduction to Linear TransformationsThe Range and Kernel of a Linear TransformationThe Correspondence and Isomorphism TheoremsMatrix of a Linear TransformationThe Algebra of L(V, W) and Mmn(F)Invertible Transformations and MatricesPolynomialsThe Algebra of PolynomialsRoots of PolynomialsTheory of a Single Linear OperatorInvariant Subspaces of an Operator

  12. Linearized theory of peridynamic states.

    Energy Technology Data Exchange (ETDEWEB)

    Silling, Stewart Andrew

    2009-04-01

    A state-based peridynamic material model describes internal forces acting on a point in terms of the collective deformation of all the material within a neighborhood of the point. In this paper, the response of a state-based peridynamic material is investigated for a small deformation superposed on a large deformation. The appropriate notion of a small deformation restricts the relative displacement between points, but it does not involve the deformation gradient (which would be undefined on a crack). The material properties that govern the linearized material response are expressed in terms of a new quantity called the modulus state. This determines the force in each bond resulting from an incremental deformation of itself or of other bonds. Conditions are derived for a linearized material model to be elastic, objective, and to satisfy balance of angular momentum. If the material is elastic, then the modulus state is obtainable from the second Frechet derivative of the strain energy density function. The equation of equilibrium with a linearized material model is a linear Fredholm integral equation of the second kind. An analogue of Poincare's theorem is proved that applies to the infinite dimensional space of all peridynamic vector states, providing a condition similar to irrotationality in vector calculus.

  13. Linearized theory of peridynamic states.

    Energy Technology Data Exchange (ETDEWEB)

    Silling, Stewart Andrew

    2009-04-01

    A state-based peridynamic material model describes internal forces acting on a point in terms of the collective deformation of all the material within a neighborhood of the point. In this paper, the response of a state-based peridynamic material is investigated for a small deformation superposed on a large deformation. The appropriate notion of a small deformation restricts the relative displacement between points, but it does not involve the deformation gradient (which would be undefined on a crack). The material properties that govern the linearized material response are expressed in terms of a new quantity called the modulus state. This determines the force in each bond resulting from an incremental deformation of itself or of other bonds. Conditions are derived for a linearized material model to be elastic, objective, and to satisfy balance of angular momentum. If the material is elastic, then the modulus state is obtainable from the second Frechet derivative of the strain energy density function. The equation of equilibrium with a linearized material model is a linear Fredholm integral equation of the second kind. An analogue of Poincare's theorem is proved that applies to the infinite dimensional space of all peridynamic vector states, providing a condition similar to irrotationality in vector calculus.

  14. The sedimentary structure of linear sand dunes

    Science.gov (United States)

    Bristow; Bailey; Lancaster

    2000-07-06

    Linear sand dunes--dunes that extend parallel to each other rather than in star-like or crescentic forms--are the most abundant type of desert sand dune. But because their development and their internal structure are poorly understood, they are rarely recognized in the rock record. Models of linear dune development have not been able to take into account the sub-surface structure of existing dunes, but have relied instead either on the extrapolation of short-term measurements of winds and sediment transport or on observations of near-surface internal sedimentary structures. From such studies, it has not been clear if linear dunes can migrate laterally. Here we present images produced by ground penetrating radar showing the three-dimensional sedimentary structure of a linear dune in the Namib sand sea, where some of the world's largest linear dunes are situated. These profiles show clear evidence for lateral migration in a linear dune. Moreover, the migration of a sinuous crest-line along the dune produces divergent sets of cross-stratification, which can become stacked as the dune height increases, and large linear dunes can support superimposed dunes that produce stacked sets of trough cross-stratification. These clear structural signatures of linear dunes should facilitate their recognition in geological records.

  15. Solitary Wave in Linear ODE with Variable Coefficients

    Institute of Scientific and Technical Information of China (English)

    LIU Shi-Da; FU Zun-Tao; LIU Shi-Kuo; XIN Guo-Jun; LIANG Fu-Ming; FENG Bei-Ye

    2003-01-01

    In this paper, the linear ordinary differential equations with variable coefficients are obtained from thecontrolling equations satisfied by wavelet transform or atmospheric internal gravity waves, and these linear equationscan be further transformed into Weber equations. From Weber equations, the homoclinic orbit solutions can be derived,so the solitary wave solutions to linear equations with variable coefficients are obtained.

  16. Signal to Noise Ratio (SNR Enhancement Comparison of Impulse-, Coding- and Novel Linear-Frequency-Chirp-Based Optical Time Domain Reflectometry (OTDR for Passive Optical Network (PON Monitoring Based on Unique Combinations of Wavelength Selective Mirrors

    Directory of Open Access Journals (Sweden)

    Christopher M. Bentz

    2014-03-01

    Full Text Available We compare optical time domain reflectometry (OTDR techniques based on conventional single impulse, coding and linear frequency chirps concerning their signal to noise ratio (SNR enhancements by measurements in a passive optical network (PON with a maximum one-way attenuation of 36.6 dB. A total of six subscribers, each represented by a unique mirror pair with narrow reflection bandwidths, are installed within a distance of 14 m. The spatial resolution of the OTDR set-up is 3.0 m.

  17. Non linear system become linear system

    Directory of Open Access Journals (Sweden)

    Petre Bucur

    2007-01-01

    Full Text Available The present paper refers to the theory and the practice of the systems regarding non-linear systems and their applications. We aimed the integration of these systems to elaborate their response as well as to highlight some outstanding features.

  18. Wide-scope screening and quantification of 50 pesticides in wine by liquid chromatography/quadrupole time-of-flight mass spectrometry combined with liquid chromatography/quadrupole linear ion trap mass spectrometry.

    Science.gov (United States)

    He, Zeying; Xu, Yaping; Wang, Lu; Peng, Yi; Luo, Ming; Cheng, Haiyan; Liu, Xiaowei

    2016-04-01

    In this paper, a wide scope screening method of pesticides in wine was established using liquid chromatography/quadrupole time-of-flight mass spectrometry (LC-QTOF MS) and liquid chromatography/quadrupole linear ion trap mass spectrometry (LC-QqLIT MS). Information dependent acquisition (IDA) experiments are used to obtain both MS and MS/MS information for LC-QTOF MS analysis. For LC-QqLIT MS analysis, MS/MS spectra of target pesticides were simultaneously acquired using Enhanced Product Ion (EPI) mode at very low concentrations to increase the confidence in analytical results of multiple reaction monitoring (MRM) by library searching. Method validation was carried out using 50 pesticides commonly used in vineyards. The LOQs, linearity, repeatability were determined and good enough for quantification. The screening and quantification results obtained using LC-QTOF MS and LC-QqLIT MS were compared. Contaminants were screened against libraries containing over 2800 compounds based on accurate mass, isotopic patterns, and MS/MS spectra searching to extend the scope of this methodology to non-target screening.

  19. Quantitative determination of multi markers in five varieties of Withania somnifera using ultra-high performance liquid chromatography with hybrid triple quadrupole linear ion trap mass spectrometer combined with multivariate analysis: Application to pharmaceutical dosage forms.

    Science.gov (United States)

    Chandra, Preeti; Kannujia, Rekha; Saxena, Ankita; Srivastava, Mukesh; Bahadur, Lal; Pal, Mahesh; Singh, Bhim Pratap; Kumar Ojha, Sanjeev; Kumar, Brijesh

    2016-09-10

    An ultra-high performance liquid chromatography electrospray ionization tandem mass spectrometry method has been developed and validated for simultaneous quantification of six major bioactive compounds in five varieties of Withania somnifera in various plant parts (leaf, stem and root). The analysis was accomplished on Waters ACQUITY UPLC BEH C18 column with linear gradient elution of water/formic acid (0.1%) and acetonitrile at a flow rate of 0.3mLmin(-1). The proposed method was validated with acceptable linearity (r(2), 0.9989-0.9998), precision (RSD, 0.16-2.01%), stability (RSD, 1.04-1.62%) and recovery (RSD ≤2.45%), under optimum conditions. The method was also successfully applied for the simultaneous determination of six marker compounds in twenty-six marketed formulations. Hierarchical cluster analysis and principal component analysis were applied to discriminate these twenty-six batches based on characteristics of the bioactive compounds. The results indicated that this method is advance, rapid, sensitive and suitable to reveal the quality of Withania somnifera and also capable of performing quality evaluation of polyherbal formulations having similar markers/raw herbs. Copyright © 2016 Elsevier B.V. All rights reserved.

  20. Linear control of the flywheel inverted pendulum.

    Science.gov (United States)

    Olivares, Manuel; Albertos, Pedro

    2014-09-01

    The flywheel inverted pendulum is an underactuated mechanical system with a nonlinear model but admitting a linear approximation around the unstable equilibrium point in the upper position. Although underactuated systems usually require nonlinear controllers, the easy tuning and understanding of linear controllers make them more attractive for designers and final users. In a recent paper, a simple PID controller was proposed by the authors, leading to an internally unstable controlled plant. To achieve global stability, two options are developed here: first by introducing an internal stabilizing controller and second by replacing the PID controller by an observer-based state feedback control. Simulation and experimental results show the effectiveness of the design.