WorldWideScience

Sample records for intermittent materno-fetal hyperoxygenation

  1. Materno-Fetal Transmission of Human Immune Deficiency Virus

    OpenAIRE

    Schäfer, Axel

    1997-01-01

    Mother-to-child transmission of human immune deficiency virus (HIV) is a multifactorial event highly associated with advanced maternal HIV disease and obstetric incidents taking place during parturition. Thus, various approaches to prevention may be beneficial. Although the time and the route of materno-fetal HIV transmission are still not sufficiently clear, much speaks in favor of a late HIV transmission, most probably taking place during parturition or the phase before the delivery. The fe...

  2. Materno-fetal transmission of human immune deficiency virus.

    Science.gov (United States)

    Schäfer, A

    1997-01-01

    Mother-to-child transmission of human immune deficiency virus (HIV) is a multifactorial event highly associated with advanced maternal HIV disease and obstetric incidents taking place during parturition. Thus, various approaches to prevention may be beneficial. Although the time and the route of materno-fetal HIV transmission are still not sufficiently clear, much speaks in favor of a late HIV transmission, most probably taking place during parturition or the phase before the delivery. The fetus is remarkably protected by the placenta and the intact fetal membranes against many viral infections during gestation. These conditions change at parturition and the chance for a transition of HIV-infected carrier cells or virus into the fetal compartment increases. Proinflammatory cytokines secreted at the materno-fetal interface accumulate in amniotic fluid and may chemoattract and stimulate potentially HIV-infected immunocytes. After rupture of membranes, maternal cells of the decidua are directly exposed to the amniotic fluid. Aside from the contamination of the fetal skin at vaginal delivery as a debatable route of infection, blood-to-blood contacts and the fetal swallowing of contaminated amniotic fluid may be the major path of fetal HIV infection. For the fetal prophylaxis of an intrauterine infection, the application of zidovudine is recommended. However, cesarian section before the onset of labor leads also to a diminution of the transmission rate. As the transmission seems to have both systemic and local causes, it makes sense to combine different intervention strategies. Whether a combination of zidovudine and elective cesarean section can lower the transmission risk further has to be evaluated.

  3. Materno-Fetal Transmission of Human Immune Deficiency Virus

    Directory of Open Access Journals (Sweden)

    Axel Schäfer

    1997-01-01

    Full Text Available Mother-to-child transmission of human immune deficiency virus (HIV is a multifactorial event highly associated with advanced maternal HIV disease and obstetric incidents taking place during parturition. Thus, various approaches to prevention may be beneficial. Although the time and the route of materno-fetal HIV transmission are still not sufficiently clear, much speaks in favor of a late HIV transmission, most probably taking place during parturition or the phase before the delivery. The fetus is remarkably protected by the placenta and the intact fetal membranes against many viral infections during gestation. These conditions change at parturition and the chance for a transition of HIV-infected carrier cells or virus into the fetal compartment increases. Proinflammatory cytokines secreted at the materno-fetal interface accumulate in amniotic fluid and may chemoattract and stimulate potentially HIV-infected immunocytes. After rupture of membranes, maternal cells of the decidua are directly exposed to the amniotic fluid. Aside from the contamination of the fetal skin at vaginal delivery as a debatable route of infection, blood-to-blood contacts and the fetal swallowing of contaminated amniotic fluid may be the major path of fetal HIV infection. For the fetal prophylaxis of an intrauterine infection, the application of zidovudine is recommended. However, cesarian section before the onset of labor leads also to a diminution of the transmission rate. As the transmission seems to have both systemic and local causes, it makes sense to combine different intervention strategies. Whether a combination of zidovudine and elective cesarean section can lower the transmission risk further has to be evaluated.

  4. Apego materno fetal em gestantes que vivem com HIV/Aids

    OpenAIRE

    Faria, Evelise Rigoni de; Gonçalves, Tonantzin Ribeiro; Carvalho, Fernanda Torres de; Ruschel, Patricia Pereira; Lopes, Rita de Cassia Sobreira; Piccinini, Cesar Augusto

    2013-01-01

    A gestação no contexto do HIV/Aids é geralmente acompanhada de intensa ansiedade devido à possível transmissão materno infantil do vírus. Este estudo investigou o apego materno fetal em gestantes que viviam com HIV (n = 88), em comparação a gestantes não portadoras do vírus (n = 79), através da Escala de Apego Materno fetal. Os resultados não revelaram diferenças entre as gestantes quanto ao escore total de apego materno fetal. Entretanto, os dados sugerem que o apego materno fetal pode se ma...

  5. Apego materno fetal em gestantes que vivem com HIV/Aids

    Directory of Open Access Journals (Sweden)

    Evelise Rigoni de Faria

    2013-06-01

    Full Text Available A gestação no contexto do HIV/Aids é geralmente acompanhada de intensa ansiedade devido à possível transmissão materno infantil do vírus. Este estudo investigou o apego materno fetal em gestantes que viviam com HIV (n = 88, em comparação a gestantes não portadoras do vírus (n = 79, através da Escala de Apego Materno fetal. Os resultados não revelaram diferenças entre as gestantes quanto ao escore total de apego materno fetal. Entretanto, os dados sugerem que o apego materno fetal pode se manifestar de maneira peculiar entre as gestantes que vivem com HIV/Aids: as interações mãe-bebê parecem focar o momento presente da gestação, e os cuidados de saúde com o bebê parecem atrelados àqueles voltados à saúde materna diante da infecção. É possível que a escala não seja suficientemente sensível para eventuais diferenças associadas ao contexto do HIV/Aids. Sugere-se que novos estudos revisem os itens da escala visando maior aproximação das particularidades suscitadas pela infecção quanto ao apego materno fetal.

  6. Vinculação da gestante e apego materno fetal

    OpenAIRE

    Schmidt, Eluisa Bordin; Argimon, Irani Iracema de Lima

    2009-01-01

    Este trabalho verificou as relações existentes entre o tipo de vinculação da gestante, sintomas de ansiedade, depressão e nível de apego materno fetal. Participaram 136 gestantes entre 18 e 42 anos de idade, do 6º ao 9º mês de gestação com escolaridade mínima de 5ª série. Foi realizado um estudo quantitativo, transversal, correlacional. Os instrumentos utilizados foram: Ficha de Dados Sociodemográficos, Escala de Vinculação do Adulto (EVA), Escala de Apego Materno Fetal (MFAS), Inventário de ...

  7. Vinculação da gestante e apego materno fetal

    Directory of Open Access Journals (Sweden)

    Eluisa Bordin Schmidt

    2009-08-01

    Full Text Available Este trabalho verificou as relações existentes entre o tipo de vinculação da gestante, sintomas de ansiedade, depressão e nível de apego materno fetal. Participaram 136 gestantes entre 18 e 42 anos de idade, do 6º ao 9º mês de gestação com escolaridade mínima de 5ª série. Foi realizado um estudo quantitativo, transversal, correlacional. Os instrumentos utilizados foram: Ficha de Dados Sociodemográficos, Escala de Vinculação do Adulto (EVA, Escala de Apego Materno Fetal (MFAS, Inventário de Depressão de Beck (BDI e Inventário de Ansiedade de Beck (BAI. A análise dos dados foi realizada por meio de estatística descritiva, teste exato de Fischer, simulações de Monte Carlo e Correlação de Pearson. Os resultados indicaram que existe associação significativa entre o tipo de vinculação da gestante e o apego materno fetal, e sintomas depressivos. As gestantes que apresentaram uma vinculação segura evidenciaram apego materno fetal alto e sintomas depressivos e ansiosos mínimos.

  8. Efeitos da ingestão de glicose sobre a circulação materno-fetal Materno-fetal hemodynamic repercussion of glucose ingestion

    Directory of Open Access Journals (Sweden)

    Rose Mary de Castro Ranciaro

    2006-12-01

    Full Text Available OBJETIVOS: analisar o efeito da glicose na hemodinâmica materno-fetal pela avaliação doplervelocimétrica da circulação materno-fetal e fetoplacentária. MÉTODOS: trata-se de estudo realizado por único observador, no qual foram incluídas 31 gestantes clinicamente sadias entre a 28ª e a 36ª semana. Os parâmetros foram avaliados imediatamente antes e 60 minutos após a ingestão de 50 g de glicose. Foram utilizados como critérios de inclusão a avaliação clínica e laboratorial normal, a presença de feto único, a idade gestacional entre a 28ª e a 36ª semana de gestação confirmada por exame de ultra-sonografia e/ou a data da última menstruação, a glicemia de jejum menor ou igual a 110 mg/dL e o teste de sobrecarga após 50 g de glicose menor de 140 mg/dL. Como critérios de exclusão, adotaram-se a presença de malformação ou alterações de desenvolvimento fetal, o trabalho de parto, os antecedentes familiares de diabetes, as patologias próprias ou intercorrentes à gestação e o uso de fumo, álcool ou outras drogas. Foram avaliados os vasos maternos da artéria carótida comum e artérias uterinas, os vasos placentários da artéria umbilical e os vasos fetais da artéria cerebral média e aorta abdominal. Foram analisados os seguintes parâmetros em cada vaso: índice de resistência, índice de pulsatilidade, velocidade sistólica máxima, velocidade diastólica final e tempo de aceleração. A freqüência cardíaca fetal foi avaliada pelo modo M da ultra-sonografia. Para análise estatística foi utilizado o teste t de Student quando a variável diferença de antes e depois da ingestão de glicose apresentou distribuição normal no teste de Kolmogorov-Smirnov. Quando a normalidade foi rejeitada, utilizamos o teste não-paramétrico de Wilcoxon, com o nível de significância sempre estabelecido de pPURPOSE: to analyze the effect of glucose in the materno-fetal hemodynamics through dopplervelocimetric assessment of

  9. [Materno-fetal infections caused by unusual germs. Apropos of 9 cases].

    Science.gov (United States)

    Rapin, F; Counil, F; Rodière, M; Astruc, J

    1989-05-01

    A retrospective study carried out from January 1981 through August 1988 identified nine cases of materno-fetal infections (Staphylococcus aureus, 1 case; Klebsiella pneumoniae, 3 cases; enterococcus, 3 cases; Hemophilus influenzae, 1 case; and Pneumococcus, 1 case) in six girls and three boys; four premature infants developed respiratory distress requiring mechanical ventilation. In four cases, maternal history found risk factors for infection. All patients developed circulatory failure and one had purulent meningitis. Diagnosis was confirmed upon recovery of the microorganism from a central sample in six cases; in three cases, only the peripheral cultures were positive but diagnosis was supported by the positive maternal history and by clinical findings. Bacterial species were not associated with specific clinical or biological features, but infections due to Hemophilus influenzae, Klebsiella pneumoniae and pneumococcus were particularly severe (two deaths and two infants with neurologic sequelae). In some studies, unusual microorganisms account for 46% of septicemias and 36% of purulent meningitis. Group D streptococci are the most common bacteria in this category and may account for 10% to 15% of early neonatal septicemias. Organism-specific features are analyzed on the basis of data from the literature. Concerning therapy, this epidemiologic aspect of materno-fetal infections complicates the choice of the initial antimicrobial agents; because third-generation cephalosporins are not effective on listeria and group D streptococci, we advocate more widespread use of the ureidopenicillins instead of ampicillin.

  10. Materno-fetal transmission of pregnancy malaria: an immunoparasitological study on 202 parturients in Maputo.

    Science.gov (United States)

    Bergström, S; Fernandes, A; Schwalbach, J; Perez, O; Miyar, R

    1993-01-01

    A total of 202 delivering mothers and their newborns were studied with the intention to follow the materno-fetal transmission of malaria. Malaria infection was encountered in 35 cases (17.3%) in which Plasmodium falciparum predominated in peripheral blood while P. malariae predominated on the placental surface. In cord blood P. falciparum was encountered in 1.5% of the cases. There was slightly more maternal infection in rural (23%) than in suburban areas (19%). Less malaria infection was encountered in primiparas than in multiparas and there was similar antibody response in both mothers and their newborns. Anaemia was encountered in 70% of the mothers and in 93% of the newborns. There was no significant correlation between low birthweight of the newborn and malaria parasitaemia in the mother.

  11. [Ballantyne syndrome caused by materno-fetal Parvovirus B19 infection: about two cases].

    Science.gov (United States)

    Desvignes, F; Bourdel, N; Laurichesse-Delmas, H; Savary, D; Gallot, D

    2011-05-01

    Ballantyne's syndrome also known as Mirror syndrome is the association of fetal hydrops and maternal hydric retention. The maternal condition is often misdiagnosed as preeclampsia. We report two cases of Ballantyne syndrome associated with materno-fetal Parvovirus B19 infection. In the first case, the syndrome occurred at 26GW in a context of premature rupture of membranes. Parents and medical staff opted for termination of pregnancy because of the poor fetal prognosis. Maternal symptoms regressed after delivery. In the second case, the patient presented a Ballantyne's syndrome at 25GW. Intrauterine transfusions reversed symptomatology. Fetal hydrops of any etiology can be associated with this syndrome. Specific treatment of the fetus can avoid maternal complication allowing continuation of the pregnancy. Copyright © 2010 Elsevier Masson SAS. All rights reserved.

  12. Materno-fetal transmission of human coronaviruses: a prospective pilot study.

    Science.gov (United States)

    Gagneur, A; Dirson, E; Audebert, S; Vallet, S; Legrand-Quillien, M C; Laurent, Y; Collet, M; Sizun, J; Oger, E; Payan, C

    2008-09-01

    This prospective pilot study investigates the possibility of materno-fetal transmission of human coronaviruses (HCoV) responsible for cases of neonatal infection. This vertical transmission was studied with 159 samples from mother-child couples: maternal vaginal (MV) and respiratory (MR) samples during labor; and newborn gastric sample (NG) with detection of HCoV (229E, OC-43, NL-63, HKU1) via real time RT PCR. HCoV was detected in 12 samples (229E: 11; HKU1: 1) from seven mother-child couples. For three couples, only MR tested positive (cases 1-3). For two other couples all three samples (MV, MR and NG) tested positive (cases 4 and 5). For case 6, only MV and NG tested positive. In case 7, only MV was positive. Possible vertical transmission of HCoV was hypothesized in this pilot study and requires further investigation on a larger scale.

  13. Materno-fetal Toxoplasma gondii infection: critical review of available diagnostic methods.

    Science.gov (United States)

    Di Carlo, Paola; Romano, Amelia; Schimmenti, Maria Gabriella; Mazzola, Angela; Titone, Lucina

    2008-03-01

    Various critical issues still surround the management of toxoplasmosis in pregnant women and neonates. Although the study of specific antibodies remains an essential parameter for diagnosing materno-fetal infection and establishing time of infection, the method needs to be carefully and critically reviewed due to the distinctive immunological sensitivity of the neonate. We began a retrospective epidemiological study of the pre-natal management of Toxoplasma gondii (TG) infection to evaluate the incidence of congenital toxoplasmosis in children in a southern Italian area (Sicily). 230 children born between 1999 and 2005 to mothers with TG infection during pregnancy enrolled in the G. Di Cristina Children's Hospital of Palermo. Retrospective analysis of the maternal sample established that 150 (65%) of the 230 infants enrolled in the study were born to a mother with probable infection, while the remaining 80 (35%) were born to a mother with definite infection. To date, the results of the neonatal follow-up programme have confirmed the diagnosis of congenital infection in 16 infants (7%); for 43%, diagnosis was made early due to the presence, at birth or in the first month of life, of specific anti-TG IgM. Sequelae were observed in 8/16 infected infants. Sequelae in infected born to mothers with infection in the third trimester opens up the problematic issue of which therapeutic approach to adopt for these women: even without consensus support, a combined regimen of Pyrimethamine-Sulfadiazine could be advocated, even in the absence of prenatal diagnosis. Currently, the best diagnostic strategy involves the sequential or contemporaneous combination of more than one of the currently available methods, as no method on its own can ensure an appropriate level of accuracy.

  14. Evolución y pronóstico materno-fetal de la cirugía cardiaca durante el embarazo

    OpenAIRE

    ÁVILA, Walkiria Samuel; GOUVEIA, Ana Maria Milani; POMERANTZEFF, Pablo; BORTOLOTTO, Maria Rita Lemos; GRINBERG, Max; STOLF, Noedir; ZUGAIB, Marcelo

    2009-01-01

    FUNDAMENTO: A cirurgia cardíaca favorece o prognóstico materno em casos refratários à terapêutica clínica, contudo associa-se a riscos ao concepto quando realizada durante a gravidez. OBJETIVO: Analisar a evolução e o prognóstico materno-fetal de gestantes submetidas à cirurgia cardíaca no ciclo gravídico-puerperal. MÉTODOS: Estudou-se a evolução de 41 gestações de mulheres que tiveram indicação de cirurgia cardíaca no ciclo gravídico puerperal. A cardiotocografia fetal foi mantida durante o ...

  15. Genomic heterogeneity of hepatitis B virus in a 54-year-old woman who contracted the infection through materno-fetal transmission.

    Science.gov (United States)

    Okamoto, H; Imai, M; Kametani, M; Nakamura, T; Mayumi, M

    1987-08-01

    From the plasma of a 54-year-old woman, who acquired the persistent carrier state of hepatitis B virus through materno-fetal transmission, 49 clones of viral genomes were propagated. They did not reveal any differences in the size and number of cleavage products with any of 11 restriction endonucleases. Randomly selected 5 clones were classified into 3 groups by the variation at 4 positions in the nucleotide sequence of the envelope and core genes. The complete nucleotide sequences were determined for 3 of them, each representing a group, and they all had a genomic length of 3215 nucleotides. Variation was found in from 5 to 11 nucleotides. Assuming the infection with the common ancestor virus at birth, hepatitis B virus genomes in her plasma were estimated to have evolved at a rate from 1.4 to 3.2 x 10(-5) nucleotide substitutions per site per year. This value is 10(4)-fold greater than DNA genomes, 10(2)-fold less than human immunodeficiency virus but in the same order as most RNA viruses including certain retroviruses.

  16. Relações entre a saúde mental da gestante e o apego materno-fetal Relations between pregnant women's mental health and maternal-fetal attachment

    Directory of Open Access Journals (Sweden)

    Patrícia Alvarenga

    2012-12-01

    Full Text Available O estudo investigou as relações entre variáveis sociodemográficas, saúde mental da gestante e o apego materno-fetal no terceiro trimestre de gestação. Participaram do estudo 261 gestantes selecionadas através de amostragem por acessibilidade em quatro maternidades públicas. As gestantes responderam individualmente uma ficha de dados sociodemográficos, a Escala de Apego Materno-Fetal e o SRQ-20. A análise de regressão revelou que o número de filhos (4% e a saúde mental materna (4,2% explicaram parte da variância no apego materno-fetal. A escolaridade da mãe e do pai não esteve associada a essa variável. O modelo de regressão múltipla considerando os quatro fatores analisados, explicou 8,2% da variância nos escores de apego materno-fetal. Discutem-se as implicações dessas variáveis na formação do vínculo da mãe com o bebê durante a gestação.This study investigated the relations among sociodemographic variables, pregnant women mental health, and maternal-fetal attachment in the third trimester of pregnancy. Participants were 261 pregnant women recruited from public maternity wards using a convenience sampling technique. Each pregnant woman completed a sociodemographic data form, the Maternal-Fetal Attachment Scale, and the SRQ-20. Regression analysis revealed that the number of children (4% and mothers' mental health (4.2% accounted for part of the variance in maternal-fetal attachment scores. Father's and mother's schooling was not associated with this variable. Taking the four analyzed factors into account, a multiple regression model accounted for 8.2% of the variance in the maternal-fetal attachment scores. The implications of these variables for mother-infant bonding during pregnancy are discussed.

  17. Contribuição do enfermeiro especialistas de saúde Materna e Obstetrícia e Ginecológica, para o bem estar materno fetal

    OpenAIRE

    Ascensão, Ana

    2016-01-01

    Relatório de Estagio apresentado para obtenção do grau de Mestre na Especialidade de Enfermagem de Saúde Materna e Obstetricia Para garantir o bem-estar materno-fetal, ao longo do parto, o Enfermeiro Especialista em Enfermagem de Saúde Materna, Obstétrica e Ginecológica deve adequar as suas intervenções a cada mulher/família, promovendo a individualização e a continuidade dos cuidados. Ao desenvolver práticas específicas, apoiadas pela evidência científica, o Enfermeiro Especialista favor...

  18. Determinants and materno-fetal outcomes related to cesarean section delivery in private and public hospitals in low- and middle-income countries: a systematic review and meta-analysis protocol.

    Science.gov (United States)

    Beogo, Idrissa; Mendez Rojas, Bomar; Gagnon, Marie-Pierre

    2017-01-14

    Despite the well-established morbidity, mortality, long-term effects, and unnecessary extra-cost burden associated with cesarean section delivery (CSD) worldwide, its rate has grown exponentially. This has become a great topical challenge for the international healthcare community and individual countries. Estimated at three times the acceptable rate as defined by the World Health Organization in 1985, the continued upward trend has been fuelled by higher income countries. Some low- and middle-income countries (LMICs) have now taken the lead, and the factors contributing to this situation are poorly understood. The expansion of the private healthcare sector may be playing a significant role. Distinguishing between the public and private hospitals' role is critical in this investigation as it has not yet been approached. This review aims to systematically synthesize knowledge on the determinants of the CSD rate rise in private and public hospitals in LMICs and to investigate materno-fetal and materno-infant outcomes of CSD in perinatal period, between private and public hospitals. We will include studies published in English, French, Spanish, and Portuguese since 2000, using any experimental design, including randomized controlled trials (RCTs), non-RCTs, quasi-experimental, before and after studies, and interrupted time series. Outcomes of interest are the determinants of CSD and materno-fetal and materno-infant outcomes. We will only include studies carried out in private and public hospitals in LMICs. The literature searches will be conducted in the following databases: MEDLINE, Embase, CINAHL, Cochrane database, LILACS, and HINARI. We will also include unpublished studies in the gray literature (theses and technical reports). Using the two-person approach, two independent review authors will screen eligible articles, extract data, and assess risk of bias. Disagreements will be resolved through discussion with a third author. Results will be presented as

  19. Evolução e prognóstico materno-fetal da cirurgia cardíaca durante a gravidez Evolución y pronóstico materno-fetal de la cirugía cardiaca durante el embarazo Maternal-fetal outcome and prognosis of cardiac surgery during pregnancy

    Directory of Open Access Journals (Sweden)

    Walkiria Samuel Ávila

    2009-07-01

    Full Text Available FUNDAMENTO: A cirurgia cardíaca favorece o prognóstico materno em casos refratários à terapêutica clínica, contudo associa-se a riscos ao concepto quando realizada durante a gravidez. OBJETIVO: Analisar a evolução e o prognóstico materno-fetal de gestantes submetidas à cirurgia cardíaca no ciclo gravídico-puerperal. MÉTODOS: Estudou-se a evolução de 41 gestações de mulheres que tiveram indicação de cirurgia cardíaca no ciclo gravídico puerperal. A cardiotocografia fetal foi mantida durante o procedimento nas pacientes com idade gestacional acima de 20 semanas. RESULTADOS: A média da idade materna foi de 27,8 ± 7,6 anos, houve predomínio da valvopatia reumática (87,8%, e 15 dessas (41,6% foram submetidas à reoperação, devido à disfunção de prótese valvar. A média do tempo de circulação extracorpórea foi de 87,4 ± 43,6 min, e a hipotermia foi utilizada em 27 casos (67,5%. Treze mães (31,7% não apresentaram intercorrências e tiveram seus recém-nascidos vivos e saudáveis. A evolução pós-operatória das demais 28 gestações (68,3% mostrou: 17 complicações maternas (41,5%; três óbitos (7,3%; 12 perdas fetais (29,2% e quatro casos de malformação neurológica (10%, dois dos quais evoluíram para óbito tardio. Houve uma perda de seguimento após a cirurgia. Nove pacientes (21,9% foram operadas em caráter de emergência, situação que influenciou (p FUNDAMENTO: La cirugía cardiaca favorece el pronóstico materno en casos refractarios a la terapéutica clínica, sin embargo está asociada a riesgos cuando realizada durante el embarazo. OBJETIVO: Analizar la evolución y el pronóstico materno-fetal de gestantes sometidas a la cirugía cardiaca en el ciclo grávido puerperal. MÉTODOS: Se estudió la evolución de 41 gestaciones de mujeres que tuvieron indicación de cirugía cardiaca en el ciclo grávido puerperal. La cardiotocografía fetal se mantuvo durante el procedimiento en las pacientes con

  20. Questionable methods of cancer management: hydrogen peroxide and other 'hyperoxygenation' therapies.

    Science.gov (United States)

    1993-01-01

    "Hyperoxygenation" therapy--also called "oxymedicine," "bio-oxidative therapy," "oxidative therapy," and "oxidology"--is a method of cancer management based on the erroneous concept that cancer is caused by oxygen deficiency and can be cured by exposing cancer cells to more oxygen than they can tolerate. The most highly touted "hyperoxygenating" agents are hydrogen peroxide, germanium sesquioxide, and ozone. Although these compounds have been the subject of legitimate research, there is little or no evidence that they are effective for the treatment of any serious disease, and each has demonstrated potential for harm. Therefore, the American Cancer Society recommends that individuals with cancer not seek treatment from individuals promoting any form of hyperoxygenation therapy as an "alternative" to proven medical modalities.

  1. Diagnósticos postnatales de anomalías del tracto urinario detectadas mediante el ultrasonido materno-fetal Postnatal diagnoses of abnormalities of the urinary tract detected by maternofetal ultrasound

    Directory of Open Access Journals (Sweden)

    Sandalio Durán Álvarez

    2004-12-01

    Full Text Available Se hace un análisis retrospectivo de los diagnósticos postnatales en niños estudiados por haberse detectado alguna anomalía o alteración del tracto urinario mediante el ultrasonido materno-fetal. Fueron enviados a la consulta externa de Nefrología del Hospital Pediátrico Docente "William Soler" 120 niños con estas características nacidos en el período comprendido entre enero 1 de 1996 y diciembre 31 de 2003. De estos 82 fueron varones (68 % .A retrospective analysis is made of the postnatal diagnoses in children studied due to the detection of some abnormality or alteration of the urinary tract by maternofetal ultrasound. 120 children with these characteristics that were born between January 1 st ,1996 and December 31 st , 2003 , were referred to the Nephrology outpatient department of “William Soler” Pediatric Teaching Hospital. Of them, 82 were males (68 %. The analysis was made in 109. 11 left the follow-up before concluding the study. The diagnoses established were: 57 non obstructive hydronephrosis (52.3 %, 17obstructive hydronephrosis (15.6 %, 16 vesicoureteral reflux (14.7 %, 7 multicystic renal dysplasia (6.4 %, 6 double excretory system (associated or not with other abnormalities (5.5 %, 2 nonobstructive megaureter (1.9 % and left renal agenesia, ureterocele in a simple system, megakaliosis and dominant autosomic policystic renal disease, one of each. The most frequent prenatal alteration was nonobstructive hydronephrosis, but due to the importance of some of the other diagnoses, all the alterations of the urinary tract detected during pregnancy should be studied and carefully followed -up in the neonatal period.

  2. CONTINUOUS MATERNAL HYPEROXYGENATION IN THE TREATMENT OF EARLY FETAL GROWTH-RETARDATION

    NARCIS (Netherlands)

    RIBBERT, LSM; VANLINGEN, RA; VISSER, GHA

    Continuous maternal hyperoxygenation treatment (2.5 l/min by means of a nasopharyngeal cannula) was given in four patients presenting with intrauterine growth-retarded (IUGR) fetuses and decelerative fetal heart rate (FHR) patterns at 27-28 weeks of gestation. The effect of maternal hyperoxia was

  3. Association between maternal-fetal genetic histocompatibility and maternal undernutrition in mice: influence on intrauterine growth Associação entre histocompatibilidade genética materno-fetal e desnutrição materna em camundongos: influência no crescimento fetal

    Directory of Open Access Journals (Sweden)

    Celso M. Rebello

    2006-04-01

    Full Text Available OBJECTIVE: The purpose of this study was to evaluate the effects of maternal-fetal genetic histocompatibility and the association of that condition with maternal undernutrition regarding fetal growth and litter size. STUDY DESIGN: Fetuses that were either syngeneic or allogeneic with the mothers were bred, using mice of well-defined syngeneic strains (A/J and Balb/c. Pregnant mice were fed using either unrestricted normal diet with 22% protein, consumed ad libitum, or a diet containing 14% protein, with intake restricted to 70% of that consumed by the unrestricted group. At the end of gestation, the number of fetoplacental units and fetal losses, the fetal and placental weight, and the weights of fetal brain and liver were recorded. RESULTS: Fetuses from undernourished mothers showed a reduction in body, placental, and brain weight (P OBJETIVO: Avaliar os efeitos da histocompatibilidade genética materno-fetal e sua associação com a desnutrição materna em relação ao crescimento fetal e número de fetos. MÉTODOS: Fetos singênicos ou alogênicos em relação às respectivas mães foram obtidos através de cruzamentos de camundongos com linhagens genéticas bem definidas (A/J e Balb/c. As fêmeas grávidas foram alimentadas ad libitum com dieta normal contendo 22% de proteínas ou dieta com restrição, contendo 14% de proteína e aporte máximo de 70% do total consumido pelo grupo em dieta livre. No final da gestação, o número de unidades feto-placentárias e de perdas fetais, o peso da placenta e do feto, assim como o peso do cérebro e do fígado foram anotados. RESULTADOS: Os fetos das mães submetidas à desnutrição mostraram redução no peso corpóreo, placentário e cerebral (p<0.01, sendo que a associação entre a compatibilidade genética materno-fetal resultou em maior restrição ao crescimento fetal (p<0.01. Foi observada uma redução no número de fetos viáveis por fêmea entre os animais do grupo de restri

  4. Hyperoxygenated hydrogen-rich solution suppresses shock- and resuscitation-induced liver injury.

    Science.gov (United States)

    Dang, Yangjie; Liu, Ting; Mei, Xiaopeng; Meng, Xiangzhong; Gou, Xingchun; Deng, Bin; Xu, Hao; Xu, Lixian

    2017-12-01

    It is not known whether simultaneous delivery of hydrogen and oxygen can reduce injury caused by hemorrhagic shock and resuscitation (HSR). This study investigated the therapeutic potential of hyperoxygenated hydrogen-rich solution (HHOS), a combined hydrogen/oxygen carrier, in a rat model of HSR-induced liver injury. Rats (n = 60) were randomly divided into 5 groups (n = 6 per group at each time point). One group underwent sham operation, and the others were subjected to severe hemorrhagic shock and then treated with lactated Ringer's solution (LRS), hydrogen-rich solution, hyperoxygenated solution, or HHOS. At 2 and 6 h after resuscitation, blood samples (n = 6) were collected from the femoral artery and serum concentrations of alanine aminotransferase and aspartate aminotransferase (AST) were measured. Rats were then sacrificed, and histopathological changes in the liver were evaluated by quantifying the percentage of apoptotic cells by caspase-3 immunohistochemistry and terminal deoxynucleotidyl transferase dUTP nick-end labeling. Inflammation was assessed by assessing malondialdehyde content and tumor necrosis factor-α, and interleukin (IL)-6 expression. Compared to lactated Ringer's solution, hydrogen-rich solution, or hyperoxygenated solution groups, serum AST and alanine aminotransferase levels and IL-6, tumor necrosis factor-α, and malondialdehyde expression in liver tissue were decreased by HHOS treatment. The number of caspase-3- and terminal deoxynucleotidyl transferase dUTP nick end labeling-positive cells was decreased (P < 0.05) by HHOS treatment, 2 and 6 h after resuscitation. HHOS has protective effects against liver injury in a rat model of HSR. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. [Topical administration of an hyperoxygenated fatty acid compound. Preventive and curative effects on pressure ulcer].

    Science.gov (United States)

    Torra i Bou, Joan-Enric; Rueda López, Justo; Segovia Gómez, Teresa; Bermejo Martínez, Mariano

    2003-01-01

    Hyper-oxygenized acidic fats are a very useful topical use product for preventing pressure ulcers and to treat stage I pressure ulcers. Mepentol is a hyper-oxygenized acidic fats product (linoleic acid, gamma linolenic acid, oleic acid, palmitic acid, stearic acid, palmitoleic acid, arachidonic acid and eicosenoic acid) with extracts of Equisetum Avrense and Hypericum Perforatum. It works in three main facets: improve as is possible the epidermis's resistance, repair the damage to the epidermis produced by a prolonged pressure, and restore capillary circulation and counter arrest the effect of oxygen radicals produced during reactive hyperemia which are caused by periods of prolonged pressure. The exclusive formula, based on hyperoxygenized acidic fats and the above referred plant extracts, gives to Mepentol a demonstrated effectiveness, and also special features, like speed of action, great speed of topical absorption and a peculiar fragrance. PATIENTS, MATERIAL AND METHOD: In order to evaluate the tissue level effect of Mepentol, we carried out an experimental research project based on two different objectives: determine the effect at capillary circulation level in heels of healthy volunteers and in patients under risk of developing pressure ulcers, a well as in the treatment of stage I pressure ulcers in patients under high risk of developing pressure ulcers. To do so, the authors determined the capillary blood flow by means of a Doppler laser flow meter. After the application of a hyper-oxygenized acidic fats product, the authors noted an increase of 122.29 +/- 68.74% in flow units related to base values. The authors also observed an increase in microcirculation in heels of patients under high risk of developing pressure ulcers, as well as those who suffer from stage I lesions. These increases remain constant over long periods of time. Based on the tests carried out, Mepentol shows an undoubtable effect which improves local circulation in zones under risk of

  6. Hyperoxygenation attenuated a murine model of atopic dermatitis through raising skin level of ROS.

    Science.gov (United States)

    Kim, Hyung-Ran; Kim, Jung-Hwan; Choi, Eun-Jeong; Lee, Yeo Kyong; Kie, Jeong-Hae; Jang, Myoung Ho; Seoh, Ju-Young

    2014-01-01

    Atopic dermatitis (AD) is a chronic inflammatory skin disease resulting from excessive stimulation of immune cells. Traditionally, reactive oxygen species (ROS) have been implicated in the progression of inflammatory diseases, but several opposing observations suggest the protective role of ROS in inflammatory disease. Recently, we demonstrated ROS prevented imiquimod-induced psoriatic dermatitis through enhancing regulatory T cell function. Thus, we hypothesized AD might also be attenuated in elevated levels of ROS through tissue hyperoxygenation, such as by hyperbaric oxygen therapy (HBOT) or applying an oxygen-carrying chemical, perfluorodecalin (PFD). Elevated levels of ROS in the skin have been demonstrated directly by staining with dihydroethidum as well as indirectly by immunohistochemistry (IHC) for indoleamine 2,3-dioxygenase (IDO). A murine model of AD was developed by repeated application of a chemical irritant (1% 2,4-dinitrochlorobenzene) and house dust mite (Dermatophagoide farinae) extract on one ear of BALB/c mice. The results showed treatment with HBOT or PFD significantly attenuated AD, comparably with 0.1% prednicarbate without any signs of side effects, such as telangiectasia. The expressions of interleukin-17A and interferon-γ were also decreased in the AD lesions by treatment with HBOT or PFD. Enhanced expression of IDO and reduced level of hypoxia-inducible factor-1α, in association with increased frequency of FoxP3+ regulatory T cells in the AD lesions, might be involved in the underlying mechanism of oxygen therapy. Taken together, it was suggested that tissue hyperoxygenation, by HBOT or treatment with PFD, might attenuate AD through enhancing skin ROS level.

  7. Hyperoxygenation attenuated a murine model of atopic dermatitis through raising skin level of ROS.

    Directory of Open Access Journals (Sweden)

    Hyung-Ran Kim

    Full Text Available Atopic dermatitis (AD is a chronic inflammatory skin disease resulting from excessive stimulation of immune cells. Traditionally, reactive oxygen species (ROS have been implicated in the progression of inflammatory diseases, but several opposing observations suggest the protective role of ROS in inflammatory disease. Recently, we demonstrated ROS prevented imiquimod-induced psoriatic dermatitis through enhancing regulatory T cell function. Thus, we hypothesized AD might also be attenuated in elevated levels of ROS through tissue hyperoxygenation, such as by hyperbaric oxygen therapy (HBOT or applying an oxygen-carrying chemical, perfluorodecalin (PFD. Elevated levels of ROS in the skin have been demonstrated directly by staining with dihydroethidum as well as indirectly by immunohistochemistry (IHC for indoleamine 2,3-dioxygenase (IDO. A murine model of AD was developed by repeated application of a chemical irritant (1% 2,4-dinitrochlorobenzene and house dust mite (Dermatophagoide farinae extract on one ear of BALB/c mice. The results showed treatment with HBOT or PFD significantly attenuated AD, comparably with 0.1% prednicarbate without any signs of side effects, such as telangiectasia. The expressions of interleukin-17A and interferon-γ were also decreased in the AD lesions by treatment with HBOT or PFD. Enhanced expression of IDO and reduced level of hypoxia-inducible factor-1α, in association with increased frequency of FoxP3+ regulatory T cells in the AD lesions, might be involved in the underlying mechanism of oxygen therapy. Taken together, it was suggested that tissue hyperoxygenation, by HBOT or treatment with PFD, might attenuate AD through enhancing skin ROS level.

  8. Moléculas que participan en el transporte de hierro materno-fetal: importancia del receptor 1 de transferrina y de la ferroportina en la placenta humana = Molecules implicated in maternal-fetal iron transport across the placental barrier: Role of Transferrin Receptor 1 and Ferroportin

    Directory of Open Access Journals (Sweden)

    Corrales Agudelo, Lady Vanessa

    2011-03-01

    Full Text Available La adecuada transferencia placentaria de hierro es crucial para satisfacer los altos requerimientos del feto y promover su adecuado crecimiento y desarrollo intrauterino; de otra parte, contribuye a prevenir la ferropenia y la anemia, entidades altamente prevalentes en los lactantes durante los primeros dos años de edad, que se asocian con mayor morbilidad y mortalidad en la infancia. La placenta es un órgano capaz de realizar diferentes adaptaciones en la producción de moléculas que participan en el transporte de hierro materno-fetal en respuesta al estado de hierro celular, para proveer la mayor disponibilidad de este mineral al feto. Esta revisión, pretende acercar al lector a los mecanismos metabólicos y moleculares relacionados con la captación, el transporte y la salida de hierro por la placenta hacia el feto, así como su regulación, para proporcionar elementos que le permitan comprender en forma integrada, la importancia de un adecuado estado de hierro materno antes y durante la gestación.

  9. [Prevention and treatment of materno-fetal toxoplasmosis].

    Science.gov (United States)

    Fortier, B; Ajana, F; Pinto de Sousa, M I; Aissi, E; Camus, D

    1991-09-21

    Preventing congenital toxoplasmosis is fundamental, and in France screening tests for primary infection are obligatory for pregnant women. All nonimmunized women should be encouraged to follow good dietary and general health rules until delivery. Nevertheless, the risk of seroconversion does exist but can be detected early through monthly serum tests. Spiramycin as initial treatment of maternal primary infection is an essential step in preventing parasite transmission to the fetus. Fetal antitoxoplasmosis antibodies and indirect signs of congenital abnormalities should be detected early by amniotic fluid and fetal blood tests before echographic evidence confirms the diagnosis. Pyrimethamine-sulfonamide therapy should be undertaken and modulated according to laboratory results in order to prevent or treat any possible fetopathy. Congenital toxoplasmosis can be prevented in utero through biological diagnosis and specific therapy.

  10. [Materno-fetal infection by the human immunodeficiency virus (HIV)].

    Science.gov (United States)

    Blanche, S

    1989-06-01

    Transmission of the HIV from mother to fetus is now virtually the only means by which children can be contaminated. Thirty to 40% of infants born to HIV-seropositive mothers are infected. Nearly half of infected neonates develop AIDS within the first two or three years of life. Early diagnosis of HIV infection rests on recovery of the virus. Early administration of azidothymidine may reduce the severity of this infection that is occurring increasingly in France, where 30,000 to 40,000 women are HIV-seropositive.

  11. [Molecular diagnosis of viral materno-fetal infections].

    Science.gov (United States)

    Grangeot-Keros, L

    2003-07-01

    The main viral infections prenatally detected in fetuses are: cytomegalovirus (CMV), parvovirus B19, rubella virus and varicella-zoster virus infections. Prenatal diagnosis is based on the direct detection of the virus by culture (CMV), of its antigens (CMV) or of its genome, essentially by PCR. This direct detection can be done either on fetal blood or on amniotic fluid. Prenatal diagnosis can also be performed by detection of specific IgM in fetal blood (rubella). Non specific markers of viral infections can also help diagnosis. At the present time, prenatal diagnosis is essentially based on the detection of the viral genome in amniotic fluid. In order to better appreciate the severity of fetal infections, some groups have tried to identify prognostic markers of these infections. The viral load could play a role in certain infections (CMV).

  12. The materno-fetal interface in llama (Lama guanicoe glama A interface materno-fetal em lhamas (Lama guanicoe glama

    Directory of Open Access Journals (Sweden)

    David M. Iturrizaga

    2007-06-01

    Full Text Available Samples from 9 llamas (28 through 36 weeks of gestation were collected and fixed in 4% buffered paraformaldehyde (light microscopy and in 2.5% buffered glutaraldehyde (transmission and scanning electron microscopy. The material was processed in paraplast and slides (5mm were stained with HE, PAS, Masson-Trichrome, acid phosphatase and Perl's. The uteroferrin was immunolocalized. The results show that llama placenta is chorioallantoic, diffuse, folded and epitheliochorial, and the fetus is covered with an epidermal membrane. The trophoblast cells have variable morphology: cubic, rounded and triangular cells, with cytoplasm containing PAS-positive granules. Binucleated cells with large cytoplasm and rounded nuclei, as well as giant trophoblastic cells with multiple nuclei were also observed. Numerous blood vessels were observed beneath the cells of the uterine epithelium and around the chorionic subdivided branches. Glandular activity was shown by PAS, Perl's, and acid phosphatase positive reactions in the cytoplasm and glandular lumen, and by immunolocalization of the uteroferrin in the glandular epithelium. The uterine glands open in spaces formed by the areoles, which are filled by PAS-positive material. The llama fetus was covered by the epidermal membrane, composed of stratified epithelium, with up to seven layers of mono-, bi- or trinucleated cells. The high level of maternal and fetal vascularization surfaces indicates an intense exchange of substances across both surfaces. The metabolic activity shown in the uterine glands suggests an adaptation of the gestation to the high altitudes of the natural habitat of this species.Fragmentos da placenta de 9 animais (28-36 semanas de gestação, provenientes do Instituto Veterinario de Investigaciones Tropicales y de Altura (IVITA, Cusco-Peru, e da Universidad del Altiplano (UNA, Puno-Peru, foram colhidos e fixados em paraformoldeído 4% em PBS para microscopia de luz e em glutaraldeido em 2,5% PBS para microscopia eletrônica de transmissão e de varredura. O material incluido em paraplast cortado com 5 mm foi processado para HE, PAS, Tricrômio de Masson, fosfatase ácida e Perl's e para imuno-histoquimica da uteroferrina. Os resultados mostraram que a placenta da lhama é corialantóide, difusa, pregueada e epiteliocorial e o feto está recoberto pela membrana epidermal. O trofoblasto possui morfologia variada: células cúbicas, arredondadas ou triangulares, com citoplasma contendo grânulos PAS+. Células binucleadas com citoplasma aumentado e núcleo arredondado e células trofoblásticas aumentados com múltiplos núcleos, também foram observadas. Grande quantidade de vasos sanguíneos foi observada entre as células do epitélio uterino e ao redor das projeções coriônicas, as quais estavam subdivididas. A atividade glandular foi demonstrada pelas reações de PAS, Perl's e fosfatase ácida positivas e pela imunolocalização da uteroferrina na luz e epitélio glandular. As glândulas uterinas abrem-se nos espaços formados pelas aréolas, as quais estavam preenchidas por material PAS+. Os fetos das lhamas estavam recobertos pela membrana epidermal, constituída por um epitélio estratificado composto por mais de 7 camadas de células mono, bi ou trinucleadas. A alta vascularização das superfícies materna e fetais indica intensa capacidade de trocas de substâncias entre as duas superfícies, e a atividade metabólica mostrada pelas glândulas uterinas sugere adaptação da gestação às altitudes elevadas do habitat natural desta espécie.

  13. Intravenous administration of hyperoxygenated solution attenuates pulmonary edema formation in phosgene-induced acute lung injury in rabbits.

    Science.gov (United States)

    Wang, Ling; Liu, Chunran; Zhang, Hui; Gao, Changjun; Chai, Wei; Xu, Ruifen; Wang, Hui-xia; Xu, Lixian

    2010-11-01

    The aim of this study was to investigate the post-treatment effect of intravenous hyperoxygenated solution (HOS) on pulmonary parameters in rabbits whole-body-exposed to the toxic gas phosgene. Twenty-four New Zealand rabbits were divided into four groups randomly: rabbits were exposed whole-body to either filtered room air or 539 ppm phosgene for 5 minutes followed by room air washout for 5 minutes. Phosgene-exposed group (exposed to phosgene without treatment, PH group); Control group (exposed to air, Control group); Lactate Ringer's solution (LRS)-treated group (intravenous infusion of LRS by 30 ml·kg-1 after phosgene exposure, LRS group); Hyperoxygenated solution (HOS)-treated group (intravenous infusion of HOS after phosgene exposure by 30 mL·kg-1, HOS group). Arterial blood was collected for blood gas analysis at 1, 3, 8, and 12 hours after phosgene or air exposure. Rabbits were put to death 12 hours after exposure. Lung edema was assessed gravimetrically by measuring tissue wet/dry weight ratio (W/D) and lung coefficient (LC). Bronchoalveolar lavage (BAL) was performed and fluid was analyzed for total maloaldehyde (MDA), glutathione peroxidase (GSH-Px), and protein concentration. Lungs were perfused with saline to remove blood, snap-frozen in liquid nitrogen (N2), analyzed for tissue reduced glutathione (GSH) and oxidized glutathione (GSSG). Parts of lung tissues were reserved for histopathology examination. In the PH, LRS, and HOS groups, phosgene inhalation caused serious lung edema, W/D and LC, lung tissue GSSG, BALF MDA, and protein content increased significantly. Meanwhile, PaO2, lung tissue GSH, and BALF GSH-Px decreased markedly. However, after HOS treatment in the HOS group, PaO2 was clearly higher than that in the PH group and LRS group at 3, 8, 12 hours (P 0.05). Intravenous HOS infusion after phosgene exposure can clearly lessen phosgene-induced lung edema formation, lipid peroxidatic reaction, and ameliorate hypoxemia associated with

  14. Synergistic combination of hyperoxygenation and radiotherapy by repeated assessments of tumor pO2 with EPR oximetry

    Science.gov (United States)

    HOU, Huagang; DONG, Ruhong; LARIVIERE, Jean P.; MUPPARAJU, Sriram P.; SWARTZ, Harold M.; KHAN, Nadeem

    2013-01-01

    The effect of hyperoxygenation with carbogen (95% O2 + 5% CO2) inhalation on RIF-1 tumor pO2 and its consequence on growth inhibition with fractionated radiotherapy is reported. The temporal changes in the tumor pO2 were assessed by in vivo Electron Paramagnetic Resonance (EPR) oximetry in mice breathing 30% O2 or carbogen and the tumors were irradiated with 4 Gy/day for 5 consecutive days; a protocol that emulates the clinical application of carbogen. The RIF-1 tumors were hypoxic with a tissue pO2 of 5 – 9 mm Hg. Carbogen (CB) breathing significantly increased tumor pO2, with a maximum increase at 22.9 – 31.2 min on days 1 – 5, however, the magnitude of increase in pO2 declined on day 5. Radiotherapy during carbogen inhalation (CB/RT) resulted in a significant tumor growth inhibition from day 3 to day 6 as compared to 30%O2/RT and carbogen (CB/Sham RT) groups. The results provide unambiguous quantitative information on the effect of carbogen inhalation on tumor pO2 over the course of 5 days. Tumor growth inhibition in the CB/RT group confirms that the tumor oxygenation with carbogen was radiobiologically significant. Repeated tumor pO2 measurements by EPR oximetry can provide temporal information that could be used to improve therapeutic outcomes by scheduling doses at times of improved tumor oxygenation. PMID:21799293

  15. Intermittency '93

    International Nuclear Information System (INIS)

    Bialas, A.

    1993-01-01

    The existing data definitely indicate the existence of intermittency, i.e. of self similar structures in the systems of particles created in high-energy collisions. The effect seems universal: it was found in most of the processes investigated and its measures parameters depend only weakly (if at all) on the process in question. Strong HBT effect was found, suggesting that intermittency is related to space-time structure of the pion source rather than to detailed momentum structure of the production amplitudes. There are indications that this space time structure may be fractal, but more data is needed to establish this. The theoretical explanation remains obscure: it seems that both parton cascade and hadronization play an important role. Their interrelation, however, remains a mystery. 5 figs., 19 refs

  16. Intermittent hyperthyreosis

    International Nuclear Information System (INIS)

    Sulman, F.G.; Tal, E.; Pfeifer, Y.; Superstine, E.

    1975-01-01

    Intermittent hyperthyreosis occurs under various forms of stress, especially heat stress. The clinician may diagnose such cases as masked or apathetic hyperthyroidism or 'forme fruste' hyperthyreosis or thyroid autonomy. As most routine and standard tests may here yield inconsistent results, it is the patients' anamnesis which may provide the clue. Our Bioclimatology Unit has now seen over 100 cases in which thyroid hypersensitivity towards heat was the most prominent syndrome: 10-15% of weather-sensitive patients are affected. The patients complain before or during heat spells of such contradictory symptoms as insomnia, irritability, tension, tachycardia, palpitations, precordial pain, dyspnoe, flushes with sweating or chills, tremor, abdominal pain or diarrhea, polyuria or pollakisuria, weight loss in spite of ravenous appetite, fatigue, exhaustion, depression, adynamia, lack of concentration and confusion. Determination of urinary neurohormones allows a differential diagnosis, intermittent hyperthyreosis being characterized by three cardinal symptoms: tachycardia - every case with more than 80 pulse beats being suspect (not specific); urinary histamine - every case excreting more than 90 μg/day being suspect. Again the drawback of this test is its lack of specificity, as histamine may also be increased in cases of allergy and spondylitis; urinary thyroxine - every case excreting more than 20 μg/day T-4 being suspect. This is the only specific test. Therapy should make use of lithium carbonate and betablockers. Propyl thiouracil is rarely required. (orig.) [de

  17. Toxoplasma-IgM and IgG-avidity in single samples from areas with a high infection rate can determine the risk of mother-to-child transmission Avidez de IgM e IgG de Toxoplasma em amostras de áreas com alta taxa de infecção pode determinar risco de transmissão materno-fetal

    Directory of Open Access Journals (Sweden)

    Myrian Morussi Reis

    2006-04-01

    Full Text Available Anti-Toxoplasma IgG-avidity was determined in 168 serum samples from IgG- and IgM-positive pregnant women at various times during pregnancy, in order to evaluate the predictive value for risk of mother-to-child transmission in a single sample, taking the limitations of conventional serology into account. The neonatal IgM was considered the serologic marker of transmission. Fluorometric tests for IgG, IgM (immunocapture and IgG-avidity were performed. Fifty-one of the 128 pregnant women tested gave birth in the hospital and neonatal IgM was obtained. The results showed 32 (62.75% pregnant women having high avidity, IgM indexes between 0.6 and 2.4, and no infected newborn. Nineteen (37.25% had low or inconclusive avidity, IgM indexes between 0.6 and 11.9, and five infected newborns and one stillbirth. In two infected newborns and the stillbirth maternal IgM indexes were low and in one infected newborn the only maternal parameter that suggested fetal risk was IgG-avidity. In the present study, IgG-avidity performed in single samples from positive IgM pregnant women helped to determine the risk of transmission at any time during pregnancy, especially when the indexes of the two tests were analysed with respect to gestational age. This model may be less expensive in developing countries where there is a high prevalence of infection than the follow-up of susceptible mothers until childbirth with monthly serology, and it creates a new perspective for the diagnosis of congenital toxoplasmosis.A avidez de IgG anti-Toxoplasma foi realizada em 168 amostras IgG e IgM positivas de gestantes, coletadas em qualquer período da gestação, para avaliar o valor preditivo do risco de transmissão materno-fetal em amostra única, considerando as limitações da sorologia convencional. A IgM neonatal foi considerada o marcador sorológico de transmissão. Testes fluorométricos foram realizados para IgG, IgM (imunocaptura e avidez de IgG. Cinqüenta e uma das 128

  18. Intermittent Explosive Disorder

    OpenAIRE

    Lut Tamam; Meliha Zengin Eroglu; Ozlem Paltaci

    2011-01-01

    Intermittent explosive disorder is an impulse control disorder characterized by the occurrence of discrete episodes of failure to resist aggressive impulses that result in violent assault or destruction of property. Though the prevalence intermittent explosive disorder has been reported to be relatively rare in frontier studies on the field, it is now common opinion that intermittent explosive disorder is far more common than previously thought especially in clinical psychiatry settings. Etio...

  19. Intermittent Explosive Disorder

    Science.gov (United States)

    ... Headache Intermittent explosive disorder Symptoms & causes Diagnosis & treatment Advertisement Mayo Clinic does not endorse companies or products. ... a Job Site Map About This Site Twitter Facebook Google YouTube Pinterest Mayo Clinic is a not- ...

  20. Intermittent Explosive Disorder

    Directory of Open Access Journals (Sweden)

    Lut Tamam

    2011-09-01

    Full Text Available Intermittent explosive disorder is an impulse control disorder characterized by the occurrence of discrete episodes of failure to resist aggressive impulses that result in violent assault or destruction of property. Though the prevalence intermittent explosive disorder has been reported to be relatively rare in frontier studies on the field, it is now common opinion that intermittent explosive disorder is far more common than previously thought especially in clinical psychiatry settings. Etiological studies displayed the role of both psychosocial factors like childhood traumas and biological factors like dysfunctional neurotransmitter systems and genetics. In differential diagnosis of the disorder, disorders involving agression as a symptom such as alcohol and drug intoxication, antisocial and borderline personality disorders, personality changes due to general medical conditions and behavioral disorder should be considered. A combination of pharmacological and psychotherapeutic approaches are suggested in the treatment of the disorder. This article briefly reviews the historical background, diagnostic criteria, epidemiology, etiology and treatment of intermittent explosive disorder.

  1. [Materno-fetal infection by Chlamydia psittaci transmitted by the goat: a new zoonosis?].

    Science.gov (United States)

    Berthier, M; Bonneau, D; Marechaud, M; Oriot, D; Deshayes, M; Levillain, P; Magnin, G

    1991-01-01

    A case report is given of spontaneous abortion at 32 weeks brought about by Chlamydia psittaci following contact with a herd of goats. Severe symptoms were observed post-natally in this woman. Nine cases of materno-foetal infection with this pathogen are known, however, the source of infection is usually ewes suffering abortive chlamydiosis. Goats may also be infected, but caprine origin for the disease in pregnant women has not been reported previously.

  2. [Cytomegalovirus retinitis in children with AIDS acquired through materno-fetal transmission].

    Science.gov (United States)

    Bremond-Gignac, D; Aron-Rosa, D; Rohrlich, P; Deplus, S; Faye, A; Vilmer, E

    1995-01-01

    To describe the clinical feature and the outcome of CMV retinitis in children with vertically transmitted HIV infection. Five case-reports of cytomegalovirus retinopathy are described. These children from eight month-old to seven and a half year-old (median age at diagnosis 52 months) had been perinatally contaminated by the human immuno-deficiency virus. The ophthalmic signs included only a red eye for one patient. The clinical signs were similar to the adult's retinopathy. At the opposite the differences were emphasized like the clinical onset with a delayed diagnosis. Mean follow-up since diagnosis is 8 months with 3 patients still alive. CMV retinitis in vertically transmitted AIDS can occur early in childhood and must be checked systematically in the patients with low CD 4 count because of the usual asymptomatic onset.

  3. [Role of group B streptococcus serotype V in materno-fetal infections].

    Science.gov (United States)

    Le Thomas, I; Lepercq, J; Bergeret, M; Francoual, C; Raymond, J

    1997-11-01

    The classification of serogroup B streptococci in serotype is based on the structural differences of capsular polysaccharides and on presence or absence of a protein c antigen. They are classified as Ia, Ia/c, Ib/c, II, II/c, III, IV and V. The serotype V, unknown in 1970, seems emerging, and is placed in third position of frequency in some American studies. We have therefore decided to evaluate its frequency in Paris. In a population of 137 pregnant women and 60 neonates carrying streptococcus of serogroup B, the serotype was systematically determined using the test "Group B streptococcus serotyping test" (Dako, Danemark). In the pregnant women population, 12% of the isolated strains were of serotype V, 26% of serotype III, 15% of serotype II, 14% of serotype Ia, and 21% could not be typed. In neonates, it represented 15% of the isolates and took place after the serotype Ia (20%), the serotype III (18%) and the serotype II (15%). None of the neonates had early- or late-onset disease. They were only colonized. Only one mother exhibited, during the per-partum, a positive blood culture with a streptococcus group B of serotype V. These results confirm, in Paris, the importance of this serotype previously observed in foreign studies. It represents 11 to 15% of the isolated streptococcus group B in the neonates and can cause early or late-onset disease. However, larger studies are needed to evaluate the exact risk of pathology for the serotype V and its significance in neonatal infectious disease.

  4. Materno-fetal immunoglobulin transfer and passive immunity during the first trimester of human pregnancy.

    Science.gov (United States)

    Jauniaux, E; Jurkovic, D; Gulbis, B; Liesnard, C; Lees, C; Campbell, S

    1995-12-01

    Passive transfer of immunity from the mother to the first trimester fetus is of particular interest because of the reported high incidence of serious fetal sequelae due to congenital infection. We have examined the relationship between maternal serum, coelomic fluid and amniotic fluid concentrations of immunoglobulin (Ig) and complement. Ig fractions G (IgG), A (IgA), and M (IgM) and complement factors 3 (C3) and 4 (C4) were measured in 34 normal pregnancies between 6 and 12 weeks of gestation. The concentrations of specific antibodies for Toxoplasma gondii, cytomegalovirus (CMV) and rubella were also measured on 21 matched samples from the same study group. IgG and IgA concentrations were detected in all coelomic fluid samples whereas IgG was only measurable in two amniotic fluid samples. IgG and IgA concentrations were respectively 28 and 128 times lower in coelomic fluid than in maternal serum and probably reflect fetal serum concentrations. Significant positive linear correlations were found between gestational age and the coelomic concentrations of IgG (P = 0.001) and IgA (P = 0.014). There was no obvious association between immunoglobulin concentrations in coelomic fluid and maternal serum suggesting increasing active transport across the placenta with advancing gestation. IgM, C3 and C4 were not detected in coelomic or amniotic fluid samples. Specific antibodies were found in 13 out of 63 samples of coelomic fluid and in 32 out of 63 samples of maternal serum. They were found in coelomic fluid only if they were present in maternal serum. These results suggest that maternal IgG and IgA are potentially available to the embryo as early as the 6th week of gestation. The presence in the coelomic fluid of the IgG fraction, both total and infectious agent-specific transferred via the placenta, indicates that they may provide limited protection against congenital infection in the first trimester.

  5. Biological aspects and diagnosis procedures of materno-fetal transmission of HIV.

    Science.gov (United States)

    Vazeux, R

    1988-06-01

    Since an estimated 1-2 million heterosexual women in Africa are infected with human immunodeficiency virus (HIV), maternal-fetal transmission of this virus is a serious issue. At this point, the only accurate data concern the high level of virus transmission from infected mothers to the newborn (at least 40%) and the severity of infection in infants. About 50% of infected infants develop acquired immunodeficiency syndrome, generally at 6 months of age, and die by the age of 3-4 years. There have been no studies large enough to determine the time of HIV transmission--antenatal, prepartum, or postpartum? Also unclear at this point are the consequences of pregnancy for the immunological status for women infected with HIV. Amniocentesis, cord blood punction, and trophoblastic biopsy are potential means of diagnosing HIV infection prenatally; however, there is a risk of infecting the fetus by the techniques themselves, a danger of false negative results and a likelihood that HIV infection can occur later in pregnancy after the tests have been completed.

  6. [Newborn bacterial infection caused by materno-fetal contamination. Retrospective epidemiologic study at a maternity unit].

    Science.gov (United States)

    Blond, M H; Gold, F; Quentin, R; Pierre, F; Kompanietz, J; Soutoul, J H; Laugier, J

    1991-01-01

    A retrospective epidemiological study of neonatal bacterial infection due to contamination from the mother was carried out in maternity unit. We analysed the results of taking bacterial swabs from the skin and GI tract in newborn children when there was a possibility, or even probability, from the criteria given that there would be infection. These results compare with different criteria. In 19 months there were 2,622 live born children; 40.6% of those had swabs taken; the infection rate was 0.61% of newborns, but 16% of the newborns, had asymptomatic colonisation by bacteria. The high risks of finding positive swabs as shown by increased infection rates by colonisation occurred where the mothers had high temperatures. Our results led us to change the criteria for antibiotic treatment immediately after birth, in newborn babies.

  7. [Materno-fetal transmission of hepatitis B virus in Ivory Coast. Plea for mass vaccination].

    Science.gov (United States)

    Lohouès-Kouacou, M J; Touré, M; Hillah, J; Camara, B M; N'Dri, N; Kouamé, K J; Attia, Y

    1998-01-01

    Hepatitis B is a major public health problem in the developing countries of Africa and Asia because the prevalence of HBs antigen carriers is high. In Ivory Coast, the prevalence of HBs antigen carriers is more than 8% (6 to 29%). In these countries, in which hepatitis B is highly endemic, most infections with hepatitis B virus (HBV) occur during early childhood. The chronic carriage of HBV was found to be common in children, who played a key role in maintaining the high level of endemicity in these areas. Vaccines against HBV are effective and their introduction as part of the Expanded Program of Immunization (EPI), as recommended by the WHO, is feasible. The aim of this study was to evaluate the prevalence of HBs antigen in pregnant women and to determine the rate of maternal transmission of HBV to the fetus, to demonstrate the importance of HBs antigen screening during pregnancy and the immunization of babies in the Ivory Coast. Between August 1995 and February 1996, 395 women in the last three months of pregnancy (age 25 +/- 6.9 years) were screened for HBs antigen. Those testing positive were also screened for HBe antigen. Transmission of HBV in utero was studied with 322 mothers and their offspring. HBs antigen was assayed in the cord blood of the offspring of HBs antigen-positive mothers. If the test for HBs antigen was positive, HBe antigen was also assayed. Second-generation ELISA tests (MONOLISA HBs Ag and MONOLISA HBe Ag from Sanofi Pasteur) were used. Babies from HBs antigen-positive mothers were vaccinated at birth with three doses of GenHevac B.

  8. [Doppler velocimetry of the aorta in materno-fetal blood incompatibility].

    Science.gov (United States)

    Favre, Y; Vetter, K; Huch, R; Huch, A

    1989-01-01

    The underlying pathogenesis of erythroblastosis fetalis is hemolysis of fetal red blood cells mediated by maternal antibodies. The resulting destruction of erythrocytes leads to progressive fetal anemia, and a hypervolemic condition develops in the fetus. The amount of maternal antibodies, real-time ultrasound, amniocentesis and/or cordocentesis can all be used to evaluate the degree of fetal anemia. The work presented here attempts to show that Doppler ultrasound can be used to detect the hypervolemic condition of anemic fetuses. One hundred fifty Doppler examinations were carried out on the aorta in 37 fetuses to evaluate the blood flow velocities and compare these with the fetal hematocrit. For the Doppler analysis, along with bidimensional echography, a Kranzbühler duplex scanner was used. In addition to the usual indices, the ratio of the median velocity to the maximum systolic velocity and an index of resistance using the maximum velocities 1/2 and 2/3 of the way through the cardiac cycle were calculated. Our examinations showed a significant increase in the temporal average of spatial average velocities (TASAV) and in the temporal average of maximum velocities (TAMV or M). The appearance of a spectral window was characteristic and a dicrotism in the curve was often observed. Much experience with the Doppler technique as well as a knowledge of factors influencing the blood flow velocity (caffeine, theine, nicotine, beta-sympathicomimetics) are necessary before attempting an interpretation of Doppler ultrasound results. Although the use of Doppler ultrasound does not yet permit a reduction in the number of invasive examinations, it does allow an improvement in the quality of surveillance of the fetal condition.

  9. [Neurogenic intermittent claudication].

    Science.gov (United States)

    Jarmundowicz, W; Haftek, J

    1984-01-01

    In the period 1971-1981 operations were carried out in 1114 cases of discopathy or lumbar spondylosis. Three patients in this group had pains of the type of intermittent claudication as the main symptoms. In all these cases narrowing of the vertebral canal was found in the lumbar part caused in two cases by degenerative changes and herniation of the intervertebral discs, and in a third case it was due to an extensive connective tissue scar at the site of previously done laminectomy. The nerve roots of the cauda were relieved from pressure surgically and in all cases pains disappeared. The authors discuss factors contributing to the development of neurogenic intermittent claudication.

  10. Fate in intermittent claudication

    DEFF Research Database (Denmark)

    Jelnes, Rolf; Gaardsting, O; Hougaard Jensen, K

    1986-01-01

    The fate of 257 consecutive patients (100 women) aged 36-85 years (mean 65) first seen with intermittent claudication in 1977 was analysed after a mean of 6.5 (SD 0.5) years. When first seen none of the patients complained of rest pain or had ulcers or gangrenous lesions on the feet. At follow up...

  11. Intermittent hypoxia and neurorehabilitation.

    Science.gov (United States)

    Gonzalez-Rothi, Elisa J; Lee, Kun-Ze; Dale, Erica A; Reier, Paul J; Mitchell, Gordon S; Fuller, David D

    2015-12-15

    In recent years, it has become clear that brief, repeated presentations of hypoxia [i.e., acute intermittent hypoxia (AIH)] can boost the efficacy of more traditional therapeutic strategies in certain cases of neurologic dysfunction. This hypothesis derives from a series of studies in animal models and human subjects performed over the past 35 yr. In 1980, Millhorn et al. (Millhorn DE, Eldridge FL, Waldrop TG. Respir Physiol 41: 87-103, 1980) showed that electrical stimulation of carotid chemoafferent neurons produced a persistent, serotonin-dependent increase in phrenic motor output that outlasts the stimulus for more than 90 min (i.e., a "respiratory memory"). AIH elicits similar phrenic "long-term facilitation" (LTF) by a mechanism that requires cervical spinal serotonin receptor activation and de novo protein synthesis. From 2003 to present, a series of studies demonstrated that AIH can induce neuroplasticity in the injured spinal cord, causing functional recovery of breathing capacity after cervical spinal injury. Subsequently, it was demonstrated that repeated AIH (rAIH) can induce recovery of limb function, and the functional benefits of rAIH are greatest when paired with task-specific training. Since uncontrolled and/or prolonged intermittent hypoxia can elicit pathophysiology, a challenge of intermittent hypoxia research is to ensure that therapeutic protocols are well below the threshold for pathogenesis. This is possible since many low dose rAIH protocols have induced functional benefits without evidence of pathology. We propose that carefully controlled rAIH is a safe and noninvasive modality that can be paired with other neurorehabilitative strategies including traditional activity-based physical therapy or cell-based therapies such as intraspinal transplantation of neural progenitors. Copyright © 2015 the American Physiological Society.

  12. Fate in intermittent claudication

    DEFF Research Database (Denmark)

    Jelnes, Rolf; Gaardsting, O; Hougaard Jensen, K

    1986-01-01

    113 of the patients (44%) had died. Causes of death were no different from those in the general population. Mortality was twice that of the general population matched for age and sex. Mortality among the men was twice that among the women. In men under 60 mortality was four times that expected......, or an ankle/arm pressure index below 50% were individually significantly associated with progression of the arteriosclerotic disease. These findings show the importance of peripheral blood pressure measurements in the management of patients with intermittent claudication due to arteriosclerotic disease....

  13. Intermittency in Complex Flows

    Science.gov (United States)

    Ben Mahjoub, Otman; Redondo, Jose M.

    2017-04-01

    Experimental results of the complex turbulent wake of a cilinder in 2D [1] and 3D flows [2] were used to investigate the scaling of structure functions, similar research was also performed on wave propagation and breaking in the Ocean [3], in the the stratified Atmosphere (ABL) [4] and in a 100large flume (UPC) for both regular and irregular waves, where long time series of waves propagating and generating breaking turbulence velocity rms and higher order measurements were taken in depth. [3,5] by means of a velocimeter SONTEK3-D. The probability distribution functions of the velocity differences and their non Gaussian distribution related to the energy spectrum indicate that irregularity is an important source of turbulence. From Kolmogorov's K41 and K61 intermittency correction: the p th-order longitudinal velocity structure function δul at scale l in the inertial range of three-dimensional fully developed turbulence is related by ⟨δup⟩ = ⟨(u(x+ l)- u(x))p⟩ ˜ ɛp0/3lp/3 l where ⟨...⟩ represents the spatial average over flow domain, with ɛ0 the mean energy dissipation per unit mass and l is the separation distance. The importance of the random nature of the energy dissipation led to the K62 theory of intermittency, but locality and non-homogeneity are key issues. p p/3 p/3 ξd ⟨δul⟩ ˜ ⟨ɛl ⟩l ˜ l and ξp = p 3 + τp/3 , where now ɛl is a fractal energy dissipation at scale l, τp/3 is the scaling of and ξp is the scaling exponent of the velocity structure function of order p. Both in K41 and K62, the structure functions of third order related to skewness is ξ3 = 1. But this is not true either. We show that scaling exponents ξp do deviate from early studies that only investigated homogeneous turbulence, where a large inertial range dominates. The use of multi-fractal analysis and improvements on Structure function calculations on standard Enhanced mixing is an essential property of turbulence and efforts to alter and to control

  14. Metabolic Effects of Intermittent Fasting.

    Science.gov (United States)

    Patterson, Ruth E; Sears, Dorothy D

    2017-08-21

    The objective of this review is to provide an overview of intermittent fasting regimens, summarize the evidence on the health benefits of intermittent fasting, and discuss physiological mechanisms by which intermittent fasting might lead to improved health outcomes. A MEDLINE search was performed using PubMed and the terms "intermittent fasting," "fasting," "time-restricted feeding," and "food timing." Modified fasting regimens appear to promote weight loss and may improve metabolic health. Several lines of evidence also support the hypothesis that eating patterns that reduce or eliminate nighttime eating and prolong nightly fasting intervals may result in sustained improvements in human health. Intermittent fasting regimens are hypothesized to influence metabolic regulation via effects on (a) circadian biology, (b) the gut microbiome, and (c) modifiable lifestyle behaviors, such as sleep. If proven to be efficacious, these eating regimens offer promising nonpharmacological approaches to improving health at the population level, with multiple public health benefits.

  15. Efectividad de los ácidos grasos hiperoxigenados en la prevención de las úlceras vasculares: Una revisión sistemática Hyperoxygenated fatty acid effectiveness in the prevention of the vascular ulcers

    Directory of Open Access Journals (Sweden)

    Eva Vives Sánchez

    2011-09-01

    Full Text Available Objetivos: conocer la eficacia de los ácidos grasos hiperoxigenados (AGHO en la prevención de las úlceras vasculares. Determinar el nivel de evidencia existente sobre el uso de ácidos grasos hiperoxigenados en la prevención de las úlceras vasculares. Material y método: se realizó una búsqueda bibliográfica en la The Cochrane Library, The Joanna Briggs Institute, PubMed-Medline y CUIDEN. Para su evaluación se han seguido las recomendaciones del sistema GRADE para la valoraciún de la evidencia y la fuerza de las recomendaciones. Resultados: en The Cochrane Library y en The Joanna Briggs Institute no aparece ningún documento que haga referencia a los AGHO. En el resto de bases de datos encontramos estudios observacionales que hacen referencia a las úlceras vasculares y AGHO. Conclusiones: aun no disponiendo de ensayos clínicos que evidencien su uso, se han venido utilizando durante los últimos años, con resultados satisfactorios, en el cuidado de la piel de las personas con alteraciones vasculares en los miembros inferiores. De acuerdo con la clasificación GRADE, todos los estudios arrojan una calidad de evidencia baja, por lo cual estimamos necesario la puesta en marcha de investigaciones que aporten mayor evidencia científica.Objectives: to determine the effectiveness of hyper-oxygenated fatty acids in the prevention of vascular ulcers. Determine the level of existing evidence the use of hyper-oxygenated fatty acids in the prevention of vascular ulcers. Material and Method: we performed a literature search of Cochrane Library, The Joanna Briggs Institute, PubMed, Medline and CUIDEN. For the evaluation, have followed the recommendations of the GRADE system for assessing evidence and strength of recommendations. Results: The Cochrane Library and The Joanna Briggs Institute does not see any document referring to AGHO. In all other databases are observational studies that relate to vascular ulcers and AGHO. Conclusions: although

  16. Intermedia and Intermittency

    Directory of Open Access Journals (Sweden)

    Veres Bálint

    2014-12-01

    Full Text Available It is commonly known that medial reflections have been initiated by attempts to secure the borders of discrete medial forms and to define the modus operandi of each essentialized medial area. Later on, the focus of study has shifted to plurimedial formations and the interactions between predefined medial genres. In the last few decades, taxonomic approaches to various multi-, inter-, and transmedial phenomena dominated the discussions, which offered invaluable support in mapping the terrain, but at the same time hindered the analysis of the ephemeral, time-dependent aspects of plurimedial operations. While we explore the properties of each medial configuration, we lose sight of the actual historical drivers that produce ever-new configurations. My thesis is that any discourse on intermediality should be paralleled by a discourse on cultural intermittency, and consequently, media studies should involve an approach that focuses on the “ecosystem” of the constantly renewing media configurations from the point of view of their vitalizing potential and capability to trigger heightened experiences. This approach draws much inspiration from K. Ludwig Pfeiffer’s media anthropology that gives orientation in my paper.

  17. Coho salmon dependence on intermittent streams.

    Science.gov (United States)

    P.J. Wigington; J.L. Ebersole; M.E. Colvin; S.G. Leibowitz; B. Miller; B. Hansen; H. Lavigne; D. White; J.P. Baker; M.R. Church; J.R. Brooks; M.A. Cairns; J.E. Compton

    2006-01-01

    In this paper, we quantify the contributions of intermittent streams to coho salmon production in an Oregon coastal watershed. We provide estimates of (1) proportion of spawning that occurred in intermittent streams, (2) movement of juveniles into intermittent streams, (3) juvenile survival in intermittent and perennial streams during winter, and (4) relative size of...

  18. Eficacia de los ácidos grasos hiperoxigenados en la prevención de las úlceras por presión Hyperoxygenated fatty acid effectiveness in the prevention of the pressure ulcers

    Directory of Open Access Journals (Sweden)

    Alonso López Escribano

    2007-12-01

    Full Text Available Objetivos: Conocer la eficacia de los ácidos grasos hiperoxigenados en la prevención de las úlceras por presión. Determinar el nivel de evidencia del uso de los ácidos grasos hiperoxigenados en la prevención de las úlceras por presión. Material y método: Se realizó una búsqueda bibliográfica en Cochrane library, The Joanna Briggs Institute, Pubmedmedline y Cuiden, siendo solamente seleccionados ensayos clínicos. Para su evaluación se han seguido las recomendaciones del Critical Appraisal Skills Programme (CASPe junto al sistema GRADE para la valoración de la calidad de la evidencia y la fuerza de las recomendaciones. Resultados: En the Cochrane Library no aparece ningún documento, mientras que en The Joanna Briggs Institute aparece un bestpractice donde no se hace ninguna referencia a los AGHO. En el resto de bases encontramos 2 ensayos clínicos aleatorizados, que cumplían los criterios CASPe. En el estudio de Gallart, et al. sobre una muestra de 192 pacientes se observó una incidencia de UPP del 19% en el grupo intervención frente al 35% del grupo placebo (p Objectives: To know the scientific evidence about hyperoxygenated fatty acid effectiveness in the prevention of the pressure ulcers and to evaluate, through the bibliography consulted, their clinical effectiveness. Material and method: There was made a compilation of information in the Cochrane library, The Joanna Briggs Institute, Pubmed-medline and Cuiden. There were only selected clinical trials, for which evaluation it has been followed the recommendations of Critical Apraisal Skill Program together with GRADE system in order to value the quality of the evidence and the strength of the recommendation. Results: No documents have been found in the Cochrane library, whereas in The Joanna Briggs Institute has been found a bestpractice where there is no reference to the hyperoxygenated fatty acid. In the rest of the databases just two randomised clinical trials that

  19. Sprint cycling training improves intermittent run performance

    Directory of Open Access Journals (Sweden)

    Hardaway Chun-Kwan Chan

    2018-01-01

    Conclusions: Sprint cycling significantly improved intermittent run performance, VO2max and peak power output at VO2max. Sprint cycling training is suitable for intermittent sports athletes but separate speed and COD training should be included.

  20. Intermittent control of coexisting attractors.

    Science.gov (United States)

    Liu, Yang; Wiercigroch, Marian; Ing, James; Pavlovskaia, Ekaterina

    2013-06-28

    This paper proposes a new control method applicable for a class of non-autonomous dynamical systems that naturally exhibit coexisting attractors. The central idea is based on knowledge of a system's basins of attraction, with control actions being applied intermittently in the time domain when the actual trajectory satisfies a proximity constraint with regards to the desired trajectory. This intermittent control uses an impulsive force to perturb one of the system attractors in order to switch the system response onto another attractor. This is carried out by bringing the perturbed state into the desired basin of attraction. The method has been applied to control both smooth and non-smooth systems, with the Duffing and impact oscillators used as examples. The strength of the intermittent control force is also considered, and a constrained intermittent control law is introduced to investigate the effect of limited control force on the efficiency of the controller. It is shown that increasing the duration of the control action and/or the number of control actuations allows one to successfully switch between the stable attractors using a lower control force. Numerical and experimental results are presented to demonstrate the effectiveness of the proposed method.

  1. Relación materno fetal y establecimiento del apego durante la etapa de gestación

    OpenAIRE

    Gómez Masera, Raquel; Alonso Martín, Pilar; Rivera Pavón, Irene

    2011-01-01

    A diario vemos ejemplos de noticias por las que nos preguntamos qué pasa por la mente de una madre para llegar a tratar de una forma tan negativa a sus hijos. Es conocida la gran importancia que tiene para el desarrollo cognitivo, emocional y social durante la infancia, el establecimiento de una adecuada relación de apego madre-bebé, desde el inicio de su vida. Pero poco se ha estudiado sobre la importancia de la formación de este apego a lo largo del embarazo. Este trabajo trata ...

  2. [Results of a national survey on the antibiotic therapy of neonatal bacterial infection due to materno-fetal contamination].

    Science.gov (United States)

    Bourrillon, A; Laik, P

    1986-03-01

    The aim of the study was to overview the antibiotic treatments usually prescribed in the different neonatal units and NICU's for neonatal primary bacterial infections. Maternal or neonatal fever, shock, respiratory distress, leuconeutropenia, hyperfibrinemia as well as an increased level in C-Reactive Protein appeared to be the best clinical diagnosis criteria. Before isolation of the bacteria, the most frequently prescribed treatment was a combination of ampicillin and gentamicin. When no bacteria grew up, the treatment was usually discontinued after a few days. When a presumably pathogenic bacteria was found either in blood, or CSF or urine or peripheral cultures, the treatment lasted around 10 days. However, in proved meningitis, the treatment lasted around 20 days. In case of Streptococcus type B and Listeria monocytogenes, ampicillin (100-200 mg/kg/day) was often used in combination with gentamicin (3-4 mg/kg/day), in spite of the recent availability of new aminoglycosides. When the isolated E. coli was ampicillin-resistant, Cefotaxime was frequently used in combination.

  3. [Contribution of direct bacteriologic examinations to the diagnosis of early materno-fetal bacterial infection: the Lille experience].

    Science.gov (United States)

    Trivier, D; Dubos, J P; Mteyrek, M; Codaccioni, X; Courcol, R J; Husson, M O

    1999-10-01

    A prospective study was conducted in 3056 live-born infants delivered at the Jeanneade-Flandre maternity hospital of the Lille Teaching Hospital between January and August 1997. Clinical, laboratory test, and microbiological test findings were compared. A cohort of 1003 infants who remained in the maternity ward but were considered at increased risk of maternofetal infection (MFI) based on history and/or obstetrical criteria and/or neonatal criteria underwent routine collection of specimens including gastric fluid, auricular and anal swabs, amniotic fluid, and placental fragments. Microscopic examination of gastric fluid smears, the first result available to the clinician, was found to have 27.5% sensitivity (983 samples). Positive predictive value (PPV) was only 17.8% because of a high rate of colonization (16.8%), defined as absence of clinical symptoms and three peripheral specimens positive for the same organism. However, negative predictive value (NPV) was as high as 99.8% as a result of high sensitivity (97.8%) in the infected neonates. The gastric fluid smear was positive in 30% and 35% of neonates born to mothers with hyperpyrexia during early and late labor, respectively, and in 42% of neonates born to mothers with a history of group B streptococcus carriage during the pregnancy. Forty-two per cent of neonates with a history of fetal tachycardia had a positive gastric fluid smear. Diagnostic criteria for infection were three peripheral specimens positive for the same organism, C-reactive protein elevation, and/or one or more clinical signs suggestive of infection, and/or a positive central specimen (blood, CSF). The infection rate in infants who remained in the maternity ward was 1.6%. The most common causative organisms were group B streptococci. These findings illustrate the useful contribution of gastric fluid smears to the early diagnosis of MFI and confirm the predominant role of group B streptococci.

  4. [HIV infection in the child after materno-fetal transmission: early treatment with azidothymidine and prevention of secondary infectious complications].

    Science.gov (United States)

    Michel, G; Vallée, D; Thuret, I; Chambost, H; Tamalet, C; de Boisse, P; Leclaire, M; Farnarier, C; Kaplanski, S; Perrimond, H

    1992-01-01

    Twenty-four perinatally HIV infected children received early treatment as soon as the diagnosis of viral contamination was established. In 13 cases (group 1), this diagnosis was based on a viremia and/or antigenemia during the first 6 months of life. In 11 cases (group 2), children were more than 15 months-old and had a positive HIV antibody test. Therapy included azidothymidine (AZT, 400 mg/m2/d) and the prevention of secondary infectious complications with intravenous immunoglobulin and cotrimoxazole. With a median follow-up of 26 months, we reported no case of severe secondary infection and no case of encephalopathy. Hematological side effects of AZT were rarely observed. Only one patient developed anemia. In all other cases, the only hematological abnormality was macrocytosis of red blood cells. Before treatment, the mean value of T4 cells age-adjusted count was 96, 86 and 91%, respectively, for groups 1, 2 and the entire study group. At the time of analysis, these values were 64, 62 and 63% respectively. This decrease was statistically significant for group 1 and for the entire study group, but did not reach statistical significance for group 2. These data show that AZT is probably insufficient as a long-term therapy for HIV infected children. Other therapeutic approaches need to be developed in the future, notably the combination of anti-retroviral drugs.

  5. Monitorização materno-fetal durante procedimento odontológico em portadora de cardiopatia valvar

    OpenAIRE

    Neves,Itamara Lucia Itagiba; Avila,Walkiria Samuel; Neves,Ricardo Simões; Giorgi,Dante Marcelo Artigas; Santos,Jorge Francisco Kuhn dos; Oliveira Filho,Ricardo Martins; Grupi,Cesar José; Grinberg,Max; Ramires,José Antonio Franchini

    2009-01-01

    FUNDAMENTO: Os efeitos da anestesia local em odontologia com lidocaína e epinefrina, sobre parâmetros cardiovasculares de gestantes portadoras de valvopatias e seus conceptos, não estão esclarecidos. OBJETIVO: Avaliar e analisar parâmetros da cardiotocografia, de pressão arterial e eletrocardiográficos da gestante portadora de doença valvar reumática, quando submetida à anestesia local com 1,8 ml de lidocaína 2% sem vasoconstritor e com epinefrina 1:100.000, durante procedimento odontológico ...

  6. Empirical heuristics for improving Intermittent Demand Forecasting

    OpenAIRE

    Petropoulos, Fotios; Nikolopoulos, Konstantinos; Spithourakis, George; Assimakopoulos, Vassilios

    2013-01-01

    Purpose– Intermittent demand appears sporadically, with some time periods not even displaying any demand at all. Even so, such patterns constitute considerable proportions of the total stock in many industrial settings. Forecasting intermittent demand is a rather difficult task but of critical importance for corresponding cost savings. The current study aims to examine the empirical outcomes of three heuristics towards the modification of established intermittent demand forecasting approaches...

  7. Probabilistic signatures of spatiotemporal intermittency in the ...

    Indian Academy of Sciences (India)

    where spatiotemporal intermittency with travelling wave laminar states and solitons is seen at points marked with boxes (2). (b) The space-time plot of spatiotemporal intermittency with solitons. the strength of nonlinearity in the map and Ω is the frequency of the map in the absence of nonlinearity. The phase diagram of the ...

  8. Intermittent behavior of the logistic system

    Science.gov (United States)

    Mayer-Kress, G.; Haken, H.

    1981-03-01

    In the discrete logistic model a transition to chaotic behavior via intermittency occurs in a neighborhood of periodic bands. Intermittent behavior is also induced if a stable periodic orbit is perturbed by low-level external noise, whereas alterations due to computer digitalisation produce remarkable periodicities. We compare our numerical results with the predictions of Pomeau and Manneville for the Lorenz system.

  9. Probabilistic signatures of spatiotemporal intermittency in the ...

    Indian Academy of Sciences (India)

    with triangles (△) and asterisks (∗). Inset shows a part of the phase diagram where spatiotemporal intermittency with travelling wave laminar states and solitons is seen at points marked with boxes (2). (b) The space-time plot of spatiotemporal intermittency with solitons. the strength of nonlinearity in the map and Ω is the ...

  10. Cosmic Rays in Intermittent Magnetic Fields

    Energy Technology Data Exchange (ETDEWEB)

    Shukurov, Anvar; Seta, Amit; Bushby, Paul J.; Wood, Toby S. [School of Mathematics and Statistics, Newcastle University, Newcastle Upon Tyne NE1 7RU (United Kingdom); Snodin, Andrew P., E-mail: a.seta1@ncl.ac.uk, E-mail: amitseta90@gmail.com [Department of Mathematics, Faculty of Applied Science, King Mongkut’s University of Technology North Bangkok, Bangkok 10800 (Thailand)

    2017-04-10

    The propagation of cosmic rays in turbulent magnetic fields is a diffusive process driven by the scattering of the charged particles by random magnetic fluctuations. Such fields are usually highly intermittent, consisting of intense magnetic filaments and ribbons surrounded by weaker, unstructured fluctuations. Studies of cosmic-ray propagation have largely overlooked intermittency, instead adopting Gaussian random magnetic fields. Using test particle simulations, we calculate cosmic-ray diffusivity in intermittent, dynamo-generated magnetic fields. The results are compared with those obtained from non-intermittent magnetic fields having identical power spectra. The presence of magnetic intermittency significantly enhances cosmic-ray diffusion over a wide range of particle energies. We demonstrate that the results can be interpreted in terms of a correlated random walk.

  11. Comparative study of the hyperbaric hyperoxygenation in ischemic colonic loops in rats Estudo comparativo da hiperoxigenação hiperbárica em alças cólicas isquêmicas em ratos

    Directory of Open Access Journals (Sweden)

    Antonio Angelo Rocha

    2007-04-01

    Full Text Available PURPOSE: To analyze and to evaluate the effect of the hyperbaric hyperoxygenation in the mechanical resistance of ischemic colon of rats. METHODS: Eighty rats, distributed in four groups of 20 animals in each one, were used. In group 1 (G1, the control group, ischemia was not caused. Group 2 was submitted to the lesser degree of ischemia. Group 3 was submitted to the intermediate degree of ischemia. In group 4, a bigger degree of intestinal ischemia was provoked. Each group was divided in two sub-groups of ten animals each: with hyperbaric chamber (CC and without hyperbaric chamber (SC. The animals of the four CC subgroups were placed in an experimental hyperbaric chamber in order to inhale oxygen at 100%, at two Absolute Atmospheres, for 120 minutes, for a four-day consecutive period. The animals of the four SC subgroups were kept in environment air during the five days of the experiment. All animals have been submitted to the mechanical study of the intestinal loop by the pressure test of the rupture by liquid distension. The euthanasia occurred in the fifth post-operative day. RESULTS: Considering the ischemia factor, the four groups were different among them (p=0.0001. There was no statistical difference between subgroups CC and SC (p=0.3461. CONCLUSION: The hyperbaric oxygen-therapy did not present improvement on the induced ischemia in rats upright colic loop.OBJETIVO: Analisar e avaliar os efeitos da hiperoxigenação hiperbárica na resistência mecânica do cólon isquêmico de ratos. MÉTODOS: Foram utilizados 80 ratos distribuídos em quatro grupos de 20 animais. No grupo 1, grupo controle, não se provocou isquemia. O grupo 2 foi submetido ao grau menor de isquemia. O grupo 3 foi submetido ao grau intermediário de isquemia. No grupo 4, provocou-se grau maior de isquemia intestinal. Cada grupo foi dividido em dois subgrupos de dez animais cada: com câmara hiperbárica (CC e sem câmara hiperbárica (SC. Os animais dos quatro

  12. Prolonged Intermittent Renal Replacement Therapy.

    Science.gov (United States)

    Edrees, Fahad; Li, Tingting; Vijayan, Anitha

    2016-05-01

    Prolonged intermittent renal replacement therapy (PIRRT) is becoming an increasingly popular alternative to continuous renal replacement therapy in critically ill patients with acute kidney injury. There are significant practice variations in the provision of PIRRT across institutions, with respect to prescription, technology, and delivery of therapy. Clinical trials have generally demonstrated that PIRRT is non-inferior to continuous renal replacement therapy regarding patient outcomes. PIRRT offers cost-effective renal replacement therapy along with other advantages such as early patient mobilization and decreased nursing time. However, due to lack of standardization of the procedure, PIRRT still poses significant challenges, especially pertaining to appropriate drug dosing. Future guidelines and clinical trials should work toward developing consensus definitions for PIRRT and ensure optimal delivery of therapy. Copyright © 2016 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

  13. Characteristics of intermittent fuel sprays

    Science.gov (United States)

    Jawad, B.; Gulari, E.; Henein, N. A.

    1992-03-01

    The spray-tip penetrations and the drop sizes of intermittent fuel sprays were measured by using a modified pulsed optical spray sizer. The average spray tip speeds were determined from simultaneously recorded needle lift signals and obscuration traces. The speeds of a sequence of fuel pulses injected at about 1000 Hz were analyzed to elucidate penetration mechanisms. A correlation that relates penetration distance to time, pressure drop across the nozzle, fuel density, and ambient gas density was obtained. The temporal variations of drop size in penetrating pulses of sprays were measured. The concentration of drops were calculated by combining drop size and obscuration data. The Sauter mean diameter of penetrating fuel drops increased with an increase of the chamber pressure and decreased with an increase of the injection pressure.

  14. Ginkgo biloba for intermittent claudication.

    Science.gov (United States)

    Nicolaï, Saskia P A; Kruidenier, Lotte M; Bendermacher, Bianca L W; Prins, Martin H; Stokmans, Rutger A; Broos, Pieter P H L; Teijink, Joep A W

    2013-06-06

    People with intermittent claudication (IC) suffer from pain in the muscles of the leg occurring during exercise which is relieved by a short period of rest. Symptomatic relief can be achieved by (supervised) exercise therapy and pharmacological treatments. Ginkgo biloba is a vasoactive agent and is used to treat IC. To assess the effect of Ginkgo biloba on walking distance in people with intermittent claudication. For this update the Cochrane Peripheral Vascular Diseases Group Trials Search Co-ordinator searched the Specialised Register (March 2013) and CENTRAL (2013, Issue 2). Randomised controlled trials of Ginkgo biloba extract, irrespective of dosage, versus placebo in people with IC. Two authors independently assessed trials for selection, assessed study quality and extracted data. We extracted number of patients, mean walking distances or times and standard deviations. To standardise walking distance or time, caloric expenditures were used to express the difference between the different treadmill protocols, which were calculated from the speed and incline of the treadmill. Fourteen trials with a total of 739 participants were included. Eleven trials involving 477 participants compared Ginkgo biloba with placebo and assessed the absolute claudication distance (ACD). Following treatment with Ginkgo biloba at the end of the study the ACD increased with an overall effect size of 3.57 kilocalories (confidence interval (CI) -0.10 to 7.23, P = 0.06), compared with placebo. This translates to an increase of just 64.5 ( CI -1.8 to 130.7) metres on a flat treadmill with an average speed of 3.2 km/h. Publication bias leading to missing data or "negative" trials is likely to have inflated the effect size. Overall, there is no evidence that Ginkgo biloba has a clinically significant benefit for patients with peripheral arterial disease.

  15. Intermittent Swimming with a Flexible Propulsor

    Science.gov (United States)

    Akoz, Emre; Moored, Keith

    2017-11-01

    Aquatic animals use a variety of swimming gaits to propel themselves efficiently through the oceans. One type of gait known as intermittent or burst-and-coast swimming is used by species such as saithe, cod and trout. Recent studies have shown that this gait can save up to 60% of a swimmer's energy by exploiting an inviscid Garrick mechanism. These detailed studies have examined the effects of an intermittent swimming gait on rigid propulsors, yet the caudal fins of intermittent swimmers are in fact highly flexible propulsors. In this respect, to gain a comprehensive understanding of intermittent swimming, the effect of elasticity on the swimming performance and wake flow of an intermittent swimmer is investigated. To accomplish this a torsional spring structural model is strongly coupled to a fast boundary element method solver that captures the fluid-structure interaction of a two-dimensional self-propelled intermittently pitching hydrofoil. It is shown that flexibility introduces extra vortices to the coasting phase of motion that can either promote or diminish thrust production depending upon the hydrofoil parameters. An optimal intermittent flexible swimmer is shown to increase its efficiency by as much as 28% when compared to an optimal continuous flexible swimmer. Supported by the Office of Naval Research under Program Director Dr. Bob Brizzolara, MURI Grant Number N00014-14-1-0533.

  16. Assessing Relative Volatility/Intermittency/Energy Dissipation

    DEFF Research Database (Denmark)

    Barndorff-Nielsen, Ole E.; Pakkanen, Mikko; Schmiegel, Jürgen

    process in particular. While this estimation method is motivated by the assessment of relative energy dissipation in empirical data of turbulence, we apply it also to energy price data. Moreover, we develop a probabilistic asymptotic theory for relative power variations of Brownian semistationary......We introduce the notion of relative volatility/intermittency and demonstrate how relative volatility statistics can be used to estimate consistently the temporal variation of volatility/intermittency even when the data of interest are generated by a non-semimartingale, or a Brownian semistationary...... processes and Ito semimartingales and discuss how it can be used for inference on relative volatility/intermittency....

  17. Intermittent cranial lung herniation in two dogs.

    Science.gov (United States)

    Guglielmini, Carlo; De Simone, Antonio; Valbonetti, Luca; Diana, Alessia

    2007-01-01

    Two aged dogs with chronic obstructive airway disease were evaluated because of intermittent swelling of the ventral cervical region. Radiographs made at expiration and caudal positioning of the forelimbs allowed identification of intermittent cervical lung herniation of the left and right cranial lung lobe in both dogs. Pulmonary hyperinflation, increased expiratory effort, and chronic coughing were considered responsible for the lung herniation. Cervical lung hernia should be included in the differential diagnoses of intermittent cervical swelling in dogs with chronic respiratory disorders associated with increased expiratory effort and chronic coughing.

  18. Lenses generated by intermittent currents

    Science.gov (United States)

    Nof, Doron

    1991-03-01

    A nonlinear mechanism for the generation of anticyclonic lens-like eddies from boundary currents is proposed. In contrast to the familiar generation processes that rely on unstable long waves that grow and close upon themselves or vortex shedding due to the geometry of the boundary, the present mechanism is related to intermittency in the current's mass transport. The essence of the new mechanism is that intermittencies in the transport (such as those in the Denmark Strait or the Mediterranean outflow) lead to unbalanced patches of fluid which break up into a discrete sets of eddies that interact with the boundary. The process is highly nonlinear because both the amplitude and the Rossby number are of order unity. It is modeled as follows: we begin with a rectangular box containing the motionless (light) fluid near the boundary. At, say, t = 0, the conceptual box is removed the unbalanced fluid undergoes two main processes. The first involves the establishment of a set of eddies via breakup and geostrophic adjustment, whereas the second is associated with the interaction of the set with the wall. These two processes are examined independently even though in reality the processes are, obviously, taking place at the same time. To examine the first processes we consider the nonlinear collapse of a (light) rectangular box in the open ocean away from the boundary. The breakup processes involves, of course, some sort of instability (because the patch does not remain intact) but this is not necessarily related to the long wave instability that is usually associated with long gravity currents. The general structures of the resulting final chain of eddies can be computed analytically by using the usual connecting principles, the conservation of potential vorticity and mass. It turns out, however, that the number of eddies and their detailed structure cannot be computed unless one invokes an additional constraint. To resolve this closure difficulty, the integrated angular

  19. Sky dancer: an intermittent system

    Science.gov (United States)

    Cros, Anne; Rodríguez Romero, Jesse Alexander; Damián Díaz Andrade, Oscar

    2009-11-01

    Sky dancers attract people sight to make advertising. What is the origin of those large vertical tubes fluctuations above an air blower? This study complements the previous one [1] about the system analysis from a dynamical system point of view. As a difference from the ``garden hose-instability'' [2], the tube shape has got ``break points''. Those ``break points'' separate the air-filled bottom tube portion from its deflated top portion. We record the tube dynamics with a high-speed videocamera simultaneously that we measure the pressure at the air blower exit. The intermittent pressure evolution displays picks when the tube fluctuates. We compare those overpressure values with the ones that appears in a rigid tube whose exit is partially obstructed. [1] F. Castillo Flores & A. Cros ``Transition to chaos of a vertical collapsible tube conveying air flow'' J. Phys.: Conf. Ser. 166, 012017 (2009). [2] A. S. Greenwald & J. Dungundji ``Static and dynamic instabilities of a propellant line'' MIT Aeroelastic and Structures Research Lab, AFOSR Sci. Report: AFOSR 67-1395 (1967).

  20. Intermittent sea-level acceleration

    Science.gov (United States)

    Olivieri, M.; Spada, G.

    2013-10-01

    Using instrumental observations from the Permanent Service for Mean Sea Level (PSMSL), we provide a new assessment of the global sea-level acceleration for the last ~ 2 centuries (1820-2010). Our results, obtained by a stack of tide gauge time series, confirm the existence of a global sea-level acceleration (GSLA) and, coherently with independent assessments so far, they point to a value close to 0.01 mm/yr2. However, differently from previous studies, we discuss how change points or abrupt inflections in individual sea-level time series have contributed to the GSLA. Our analysis, based on methods borrowed from econometrics, suggests the existence of two distinct driving mechanisms for the GSLA, both involving a minority of tide gauges globally. The first effectively implies a gradual increase in the rate of sea-level rise at individual tide gauges, while the second is manifest through a sequence of catastrophic variations of the sea-level trend. These occurred intermittently since the end of the 19th century and became more frequent during the last four decades.

  1. Social Smoking among Intermittent Smokers

    Science.gov (United States)

    Shiffman, Saul; Li, Xiaoxue; Dunbar, Michael S.; Ferguson, Stuart G.; Tindle, Hilary A.; Scholl, Sarah M.

    2015-01-01

    Background “Social smoking” - smoking mostly or even only with others – may be an important pattern that implies smoking motivated extrinsically by social influences. Non-daily smokers (intermittent smokers; ITS) are often assumed to be social smokers, with some authors even assuming that all ITS are social smokers (SS+). We sought to identify and characterize social smokers in a sample of ITS. Methods 204 adult ITS (smoking 4–27 days/month) recorded the circumstances of smoking in their natural settings using Ecological Momentary Assessment, while also recording their circumstances in nonsmoking moments. SS+ were defined as ITS who were with others when they smoked most of their cigarettes, and who were ≥ 50% more likely to be with others when smoking than when not. Results Only 13% of ITS were SS+. Although defined solely on the basis of presence of others, SS+ showed a distinct pattern of smoking across multiple dimensions: Compared to other ITS (who were significantly less likely to smoke when with others), SS+ smoking was more associated with socializing, being with friends and acquaintances, drinking alcohol, weekends, evening or nighttime, being in other people’s homes, but not their own home. SS+ smoking was low in the morning and increased in the evening. SS+ smoked fewer days/week and were less dependent, but did not differ demographically. Conclusions Social smoking does constitute a highly distinct smoking pattern, but is not common among adult ITS. PMID:26205313

  2. On-line intermittent connector anomaly detection

    Data.gov (United States)

    National Aeronautics and Space Administration — This paper investigates a non-traditional use of differential current sensor and current sensor to detect intermittent disconnection problems in connectors. An...

  3. Intermittent chaotic chimeras for coupled rotators

    DEFF Research Database (Denmark)

    Olmi, Simona; Martens, Erik Andreas; Thutupalli, Shashi

    2015-01-01

    Two symmetrically coupled populations of N oscillators with inertia m display chaotic solutions with broken symmetry similar to experimental observations with mechanical pendulums. In particular, we report evidence of intermittent chaotic chimeras, where one population is synchronized and the other...

  4. Bladder Management in Children: Intermittent Catheterization Education.

    Science.gov (United States)

    Fortuna, Suzanne Marie; Korcal, Layna; Thomas, Ginger

    2018-03-01

    Clean intermittent catheterization (IC) of the bladder is one example of advanced medical care required by students with special health care needs. The success of a child's intermittent catheterization program in a community setting such as a school is dependent on an educated team. This article discusses indications and problems that arise with IC bladder management in the pediatric population. The article also provides information about current best practice for IC management to assist school nurses in the optimization of bladder health.

  5. Exercise training for intermittent claudication.

    Science.gov (United States)

    McDermott, Mary M

    2017-11-01

    The objective of this study was to provide an overview of evidence regarding exercise therapies for patients with lower extremity peripheral artery disease (PAD). This manuscript summarizes the content of a lecture delivered as part of the 2016 Crawford Critical Issues Symposium. Multiple randomized clinical trials demonstrate that supervised treadmill exercise significantly improves treadmill walking performance in people with PAD and intermittent claudication symptoms. A meta-analysis of 25 randomized trials demonstrated a 180-meter increase in treadmill walking distance in response to supervised exercise interventions compared with a nonexercising control group. Supervised treadmill exercise has been inaccessible to many patients with PAD because of lack of medical insurance coverage. However, in 2017, the Centers for Medicare and Medicaid Services issued a decision memorandum to support health insurance coverage of 12 weeks of supervised treadmill exercise for patients with walking impairment due to PAD. Recent evidence also supports home-based walking exercise to improve walking performance in people with PAD. Effective home-exercise programs incorporate behavioral change interventions such as a remote coach, goal setting, and self-monitoring. Supervised treadmill exercise programs preferentially improve treadmill walking performance, whereas home-based walking exercise programs preferentially improve corridor walking, such as the 6-minute walk test. Clinical trial evidence also supports arm or leg ergometry exercise to improve walking endurance in people with PAD. Treadmill walking exercise appears superior to resistance training alone for improving walking endurance. Supervised treadmill exercise significantly improves treadmill walking performance in people with PAD by approximately 180 meters compared with no exercise. Recent evidence suggests that home-based exercise is also effective and preferentially improves over-ground walking performance, such as

  6. The Yo-Yo intermittent recovery test

    DEFF Research Database (Denmark)

    Bangsbo, Jens; Iaia, F. Marcello; Krustrup, Peter

    2008-01-01

    The two Yo-Yo intermittent recovery (IR) tests evaluate an individual's ability to repeatedly perform intense exercise. The Yo-Yo IR level 1 (Yo-Yo IR1) test focuses on the capacity to carry out intermittent exercise leading to a maximal activation of the aerobic system, whereas Yo-Yo IR level 2...... (Yo-Yo IR2) determines an individual's ability to recover from repeated exercise with a high contribution from the anaerobic system. Evaluations of elite athletes in various sports involving intermittent exercise showed that the higher the level of competition the better an athlete performs in the Yo......-Yo IR tests. Performance in the Yo-Yo IR tests for young athletes increases with rising age. The Yo-Yo IR tests have shown to be a more sensitive measure of changes in performance than maximum oxygen uptake. The Yo-Yo IR tests provide a simple and valid way to obtain important information...

  7. Assessing relative volatility/intermittency/energy dissipation

    DEFF Research Database (Denmark)

    Barndorff-Nielsen, Ole E.; Pakkanen, Mikko S.; Schmiegel, Jürgen

    2014-01-01

    process in particular. This estimation method is motivated by the assessment of relative energy dissipation in empirical data of turbulence, but it is also applicable in other areas. We develop a probabilistic asymptotic theory for realised relative power variations of Brownian semistationary processes......, and introduce inference methods based on the theory. We also discuss how to extend the asymptotic theory to other classes of processes exhibiting stochastic volatility/intermittency. As an empirical application, we study relative energy dissipation in data of atmospheric turbulence.......We introduce the notion of relative volatility/intermittency and demonstrate how relative volatility statistics can be used to estimate consistently the temporal variation of volatility/intermittency when the data of interest are generated by a non-semimartingale, or a Brownian semistationary...

  8. Forces and energetics of intermittent swimming

    Science.gov (United States)

    Floryan, Daniel; Van Buren, Tyler; Smits, Alexander J.

    2017-08-01

    Experiments are reported on intermittent swimming motions. Water tunnel experiments on a nominally two-dimensional pitching foil show that the mean thrust and power scale linearly with the duty cycle, from a value of 0.2 all the way up to continuous motions, indicating that individual bursts of activity in intermittent motions are independent of each other. This conclusion is corroborated by particle image velocimetry (PIV) flow visualizations, which show that the main vortical structures in the wake do not change with duty cycle. The experimental data also demonstrate that intermittent motions are generally energetically advantageous over continuous motions. When metabolic energy losses are taken into account, this conclusion is maintained for metabolic power fractions less than 1.

  9. Unsteady propulsion by an intermittent swimming gait

    Science.gov (United States)

    Akoz, Emre; Moored, Keith W.

    2018-01-01

    Inviscid computational results are presented on a self-propelled swimmer modeled as a virtual body combined with a two-dimensional hydrofoil pitching intermittently about its leading edge. Lighthill (1971) originally proposed that this burst-and-coast behavior can save fish energy during swimming by taking advantage of the viscous Bone-Lighthill boundary layer thinning mechanism. Here, an additional inviscid Garrick mechanism is discovered that allows swimmers to control the ratio of their added mass thrust-producing forces to their circulatory drag-inducing forces by decreasing their duty cycle, DC, of locomotion. This mechanism can save intermittent swimmers as much as 60% of the energy it takes to swim continuously at the same speed. The inviscid energy savings are shown to increase with increasing amplitude of motion, increase with decreasing Lighthill number, Li, and switch to an energetic cost above continuous swimming for sufficiently low DC. Intermittent swimmers are observed to shed four vortices per cycle that form into groups that are self-similar with the DC. In addition, previous thrust and power scaling laws of continuous self-propelled swimming are further generalized to include intermittent swimming. The key is that by averaging the thrust and power coefficients over only the bursting period then the intermittent problem can be transformed into a continuous one. Furthermore, the intermittent thrust and power scaling relations are extended to predict the mean speed and cost of transport of swimmers. By tuning a few coefficients with a handful of simulations these self-propelled relations can become predictive. In the current study, the mean speed and cost of transport are predicted to within 3% and 18% of their full-scale values by using these relations.

  10. The Yo-Yo intermittent recovery test

    DEFF Research Database (Denmark)

    Bangsbo, Jens; Iaia, F. Marcello; Krustrup, Peter

    2008-01-01

    The two Yo-Yo intermittent recovery (IR) tests evaluate an individual's ability to repeatedly perform intense exercise. The Yo-Yo IR level 1 (Yo-Yo IR1) test focuses on the capacity to carry out intermittent exercise leading to a maximal activation of the aerobic system, whereas Yo-Yo IR level 2......-Yo IR tests. Performance in the Yo-Yo IR tests for young athletes increases with rising age. The Yo-Yo IR tests have shown to be a more sensitive measure of changes in performance than maximum oxygen uptake. The Yo-Yo IR tests provide a simple and valid way to obtain important information...

  11. Sprint cycling training improves intermittent run performance

    OpenAIRE

    Hardaway Chun-Kwan Chan; Weeraya Ka-Yan Ho; Patrick Shu-Hang Yung

    2018-01-01

    Background/Objective: The aim of this study was to examine the effect of sprint cycling training on the intermittent run performance, sprinting speed, and change of direction (COD) ability of recreational intermittent sports athletes. Methods: Sixteen participants participated in the study. The experimental group (EG, n = 8) received a total of 12 sessions of sprint cycling training in a 4-week period and the control group (CG, n = 8) received no training. Both EG and CG were instructed to...

  12. Fractal structures and intermittency in QCD

    International Nuclear Information System (INIS)

    Gustafson, Goesta.

    1990-04-01

    New results are presented for fractal structures and intermittency in QCD parton showers. A geometrical interpretation of the anomalous dimension in QCD is given. It is shown that model predications for factorial moments in the PEP-PETRA energy range are increased. if the properties of directly produced pions are more carefully taken into account

  13. Intermittent mechanical and clinical intravalvar regurgitation aortic ...

    African Journals Online (AJOL)

    due to intravalvar occlusion caused by thrombosis and/or tissue ingrowth or to periprosthetic regurgitation. .... position). A. The tilting disc of the prosthetic aortic valve is in the normal closed position during diastole. B. The disc is 'stuck' in the open position during diastole. Intermittent AR in patients with aortic prosthetic ...

  14. Intermittent and global transitions in plasma turbulence

    International Nuclear Information System (INIS)

    Vlad, M.; Spineanu, F.; Itoh, K.; Itoh, S.-I.

    2003-07-01

    The dynamics of the transition processes in plasma turbulence described by the nonlinear Langevin equation (1) is studied. We show that intermittent or global transitions between metastable states can appear. The conditions for the generation of these transitions and their statistical characteristics are determined. (author)

  15. Acute intermittent porphyria presenting as progressive muscular ...

    African Journals Online (AJOL)

    Acute intermittent porphyria, the most common porphyria affecting the nervous system, typically presents with neurovisceral crises followed by a motor neuropathy. We describe a 23-year-old black South African man presenting with a progressive stuttering, lower motor neuron syndrome developing over months. He had not ...

  16. Walking training for intermittent claudication in diabetes

    NARCIS (Netherlands)

    Ubels, FL; Links, TP; Sluiter, WJ; Smit, AJ

    OBJECTIVE - Walking training (WT) is an established treatment for patients with intermittent claudication (IC). Abnormalities specific to diabetes, such as a relative preponderance of distal lesions and the contribution of microcirculatory disease, might well influence the results of WT. We compared

  17. Cooling tower modification for intermittent operation

    International Nuclear Information System (INIS)

    Midkiff, W.S.

    1975-03-01

    One of the cooling towers at Los Alamos Scientific Laboratory is being operated intermittently. The cooling tower has been modified to restrict air flow and to keep the tower from drying out. The modifications are relatively inexpensive, simple to operate, and have proved effective. (U.S.)

  18. Intermittent demand : Linking forecasting to inventory obsolescence

    NARCIS (Netherlands)

    Teunter, Ruud H.; Syntetos, Aris A.; Babai, M. Zied

    2011-01-01

    The standard method to forecast intermittent demand is that by Croston. This method is available in ERP-type solutions such as SAP and specialised forecasting software packages (e.g. Forecast Pro), and often applied in practice. It uses exponential smoothing to separately update the estimated demand

  19. Prevalence of intermittent preventive treatment with sulphadoxine ...

    African Journals Online (AJOL)

    Cite as: Orish VN, Onyeabor OS, Boampong JN , Afoakwah R, Nwaefuna E, Acquah S, et al. Prevalence of intermittent preventive treat- ment with sulphadoxine-pyrimethamine (IPTp-SP) use ..... by the increase of SP drug resistance in pregnant wom- en in Ghana since the adoption and implementation of. IPTp-SP policy35.

  20. Intermittent resistive faults in digital cmos circuits

    NARCIS (Netherlands)

    Kerkhoff, Hans G.; Ebrahimi, Hassan

    2015-01-01

    A major threat in extremely dependable high-end process node integrated systems in e.g. Avionics are no failures found (NFF). One category of NFFs is the intermittent resistive fault, often originating from bad (e.g. Via or TSV-based) interconnections. This paper will show the impact of these faults

  1. 40 CFR 51.119 - Intermittent control systems.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 2 2010-07-01 2010-07-01 false Intermittent control systems. 51.119... Intermittent control systems. (a) The use of an intermittent control system (ICS) may be taken into account in... of any constant pollution control system which was in use before December 31, 1970, or the equivalent...

  2. CONDITIONED ANALYSIS OF HIGH-LATITUDE SOLAR WIND INTERMITTENCY

    International Nuclear Information System (INIS)

    D'Amicis, R.; Consolini, G.; Bavassano, B.; Bruno, R.

    2012-01-01

    The solar wind is a turbulent medium displaying intermittency. Its intermittent features have been widely documented and studied, showing how the intermittent character is different in fast and slow wind. In this paper, a statistical conditioned analysis of the solar wind intermittency for a period of high-latitude fast solar wind is presented. In particular, the intermittent features are investigated as a function of the Alfvénic degree of fluctuations at a given scale. The results show that the main contribution to solar wind intermittency is due to non-Alfvénic structures, while Alfvénic increments are found to be characterized by a smaller level of intermittency than the previous ones. Furthermore, the lifetime statistics of Alfvénic periods are discussed in terms of a multiscale texture of randomly oriented flux tubes.

  3. Insights from intermittent binocular rivalry and EEG

    Directory of Open Access Journals (Sweden)

    Michael A Pitts

    2011-09-01

    Full Text Available Novel stimulation and analytical approaches employed in EEG studies of ambiguous figures have recently been applied to binocular rivalry. The combination of intermittent stimulus presentation and EEG source imaging has begun to shed new light on the neural underpinnings of binocular rivalry. Here, we review the basics of the intermittent paradigm and highlight methodological issues important for interpreting previous results and designing future experiments. We then outline current analytical approaches, including EEG microstates, event-related potentials, and statistically-based source estimation, and propose a spatio-temporal model that integrates findings from several studies. Finally, we discuss the advantages and limitations of using binocular rivalry as a tool to investigate the neural basis of perceptual awareness.

  4. Effects of vacusac in intermittent claudication

    DEFF Research Database (Denmark)

    Himmelstrup, H; Himmelstrup, Bodil; Mehlsen, J

    1991-01-01

    The effect of a new physical treatment modality, Vacusac, was tested on a group of patients with stable intermittent claudication. Twenty-two patients with a median age of 65 years and a median duration of intermittent claudication of 5 years were randomized to either active or placebo treatments....... Seventeen patients completed the study. The effect of treatment was quantified by measurements of systemic and peripheral systolic blood pressures and by measurements of the pain-free and the maximal walking distance on a treadmill. The ankle pressure index (ankle systolic pressure/arm systolic pressure......) and toe pressure index (toe systolic pressure/arm systolic pressure) were calculated. After 25 active treatments, administered over a period of 2 months, the patients allocated to this group attained a significant increase in the pain-free walking distance from 54 m (24-107 m) to 99 m (30-420 m) (P less...

  5. Intermittent character of interplanetary magnetic field fluctuations

    International Nuclear Information System (INIS)

    Bruno, Roberto; Carbone, Vincenzo; Chapman, Sandra; Hnat, Bogdan; Noullez, Alain; Sorriso-Valvo, Luca

    2007-01-01

    Interplanetary magnetic field magnitude fluctuations are notoriously more intermittent than velocity fluctuations in both fast and slow wind. This behavior has been interpreted in terms of the anomalous scaling observed in passive scalars in fully developed hydrodynamic turbulence. In this paper, the strong intermittent nature of the interplanetary magnetic field is briefly discussed comparing results performed during different phases of the solar cycle. The scaling properties of the interplanetary magnetic field magnitude show solar cycle variation that can be distinguished in the scaling exponents revealed by structure functions. The scaling exponents observed around the solar maximum coincide, within the errors, to those measured for passive scalars in hydrodynamic turbulence. However, it is also found that the values are not universal in the sense that the solar cycle variation may be reflected in dependence on the structure of the velocity field

  6. Intermittency exponent of the turbulent energy cascade

    International Nuclear Information System (INIS)

    Cleve, J.; Greiner, M.; Pearson, B.R.; Sreenivasan, K.R.

    2006-12-01

    We consider the turbulent energy dissipation from one-dimensional records in experiments using air and gaseous helium at cryogenic temperatures, and obtain the intermittency exponent via the two-point correlation function of the energy dissipation. The air data are obtained in a number of flows in a wind tunnel and the atmospheric boundary layer at a height of about 35 m above the ground. The helium data correspond to the centerline of a jet exhausting into a container. The air data on the intermittency exponent are consistent with each other and with a trend that increases with the Taylor microscale Reynolds number, R λ , of up to about 1000 and saturates thereafter. On the other hand, the helium data cluster around a constant value at nearly all R λ , this being about half of the asymptotic value for the air data. Some possible explanation is offered for this anomaly. (author)

  7. Optimal intermittent search strategies: smelling the prey

    International Nuclear Information System (INIS)

    Revelli, J A; Wio, H S; Rojo, F; Budde, C E

    2010-01-01

    We study the kinetics of the search of a single fixed target by a searcher/walker that performs an intermittent random walk, characterized by different states of motion. In addition, we assume that the walker has the ability to detect the scent left by the prey/target in its surroundings. Our results, in agreement with intuition, indicate that the prey's survival probability could be strongly reduced (increased) if the predator is attracted (or repelled) by the trace left by the prey. We have also found that, for a positive trace (the predator is guided towards the prey), increasing the inhomogeneity's size reduces the prey's survival probability, while the optimal value of α (the parameter that regulates intermittency) ceases to exist. The agreement between theory and numerical simulations is excellent.

  8. Downstream effects of intermittent power generation

    Energy Technology Data Exchange (ETDEWEB)

    Bretschko, G. (Austrian Academy of Sciences, Lunz (AT). Inst. fuer Limnologie); Moog, O. (Univ. Agric., Vienna (AT). Inst. Water Prov., Water Quality and Fisheries Management)

    1990-01-01

    Intermittent hydro-power generation creates frequent and dramatic discharge peaks combined with intervening extremely low water conditions downstream of the plant. Studies of the two Austrian rivers showed that whereas no alterations were found in the qualitative composition of zoobenthos, the decrease in abundance and biomass may amount up to 95%. The mismatch between the hydrography of surface water and groundwater might well be a cause of the detrimental effects of frequent and artificially created spates. The drastic reduction of zoobenthic biomass affects not only fish production but minimizes self-purification processes as well. Until tributaries diminish the effects of intermittent power generation, the river is reduced to a mere transport vehicle. (author).

  9. Intermittent preventive treatment of malaria in pregnancy

    DEFF Research Database (Denmark)

    Mbonye, A.K.; Bygbjerg, Ib Christian; Magnussen, Pascal

    2008-01-01

    OBJECTIVE: To assess whether traditional birth attendants, drug-shop vendors, community reproductive-health workers, or adolescent peer mobilizers could administer intermittent preventive treatment (IPTp) for malaria with sulfadoxine-pyrimethamine to pregnant women. METHODS: A non-randomized comm......OBJECTIVE: To assess whether traditional birth attendants, drug-shop vendors, community reproductive-health workers, or adolescent peer mobilizers could administer intermittent preventive treatment (IPTp) for malaria with sulfadoxine-pyrimethamine to pregnant women. METHODS: A non......, still births, and maternal and child deaths were secondary endpoints. FINDINGS: 1404 (67.5%) of 2081 with the new delivery system received two doses of sulfadoxine-pyrimethamine versus 281 (39.9%) of 704 with health units (P

  10. Long-range forecasting of intermittent streamflow

    OpenAIRE

    F. F. van Ogtrop; R. W. Vervoort; G. Z. Heller; D. M. Stasinopoulos; R. A. Rigby

    2011-01-01

    Long-range forecasting of intermittent streamflow in semi-arid Australia poses a number of major challenges. One of the challenges relates to modelling zero, skewed, non-stationary, and non-linear data. To address this, a statistical model to forecast streamflow up to 12 months ahead is applied to five semi-arid catchments in South Western Queensland. The model uses logistic regression through Generalised Additive Models for Location, Scale and Shape (GAMLSS) to determine th...

  11. Long-range forecasting of intermittent streamflow

    OpenAIRE

    F. F. van Ogtrop; R. W. Vervoort; G. Z. Heller; D. M. Stasinopoulos; R. A. Rigby

    2011-01-01

    Long-range forecasting of intermittent streamflow in semi-arid Australia poses a number of major challenges. One of the challenges relates to modelling zero, skewed, non-stationary, and non-linear data. To address this, a probabilistic statistical model to forecast streamflow 12 months ahead is applied to five semi-arid catchments in South Western Queensland. The model uses logistic regression through Generalised Additive Models for Location, Scale and Shape (GAMLSS) to determine the probabil...

  12. Climate, intermittent humidification, and humidifier fever.

    OpenAIRE

    Anderson, K; Watt, A D; Sinclair, D; Lewis, C; McSharry, C P; Boyd, G

    1989-01-01

    Two summer outbreaks of humidifier fever (HF) are described in a microprocessor factory (factory A) and a printing factory (factory B). The air in each factory was humidified intermittently and controlled by present humidistats operating to maintain a relative humidity of 45% by an air handler incorporating a spray humidifier in factory A and two ceiling mounted spray humidifiers in factory B. Questionnaire data from each workforce suggested that although symptoms apparently occurred most com...

  13. AN ELDERLY WOMAN WITH INTERMITTENT CLAUDICATION

    Directory of Open Access Journals (Sweden)

    Nayyer Naveed Wazir

    2006-01-01

    Full Text Available This case report illustrates the misdiagnosis of intermittent claudication in an elderly with multiple cardiac risk factors. Careful clinical evaluation and imaging shifts the diagnosis from peripheral vascular disease to spinal stenosis. The decision whether to offer conservative therapy or proceed to spinal surgery requires an accurate assessment of the severity of the symptoms without ignoring the important role of patient preferences.

  14. Intermittent structures in atmospheric wind fields

    Energy Technology Data Exchange (ETDEWEB)

    Yueksek, Oersan; Muecke, Tanja; Peinke, Joachim [Wind Center for Wind Energy Research, University of Oldenburg (Germany)

    2011-07-01

    For design processes and load calculations of wind energy convertors (WEC) realistic synthetic wind fields are needed. The widely used norm is the standard IEC 61400. The IEC standard considers different simulation methods based on Gaussian statistics. However, the analysis of the measured wind fields by means of velocity increment statistics yields that these do not obey Gaussian statistics but are quite intermittent. The intermittent nature of atmospheric wind affects the whole chain of the wind energy conversion process and is assumed to be a major effect for additional loads and fatigue. A recently proposed method based on continuous time random walks (CTRWs) adequately reproduces the intermittency of turbulent atmospheric velocity increments on small time scales and provides wind fields with the desired high order two point statistics. In this work, we analyze highly time-resolved data sets measured in an extensive grid over the whole rotor plane of a WEC. The atmospheric wind fields are characterized statistically and the dependency of the higher order two point statistics on turbulence intensity, mean wind speed and height is shown. With this knowledge we are able to generate synthetic CTRW wind fields with the correct small scale structure.

  15. [Embolization of a ruptured pseudo-aneurysm of the uterine artery at 26weeks of gestation: Materno-fetal consequences; a case-report].

    Science.gov (United States)

    Maignien, C; Marcellin, L; Anselem, O; Silvera, S; Dousset, B; Grangé, G; Goffinet, F

    2015-09-01

    Rupture of a uterine artery pseudo-aneurysm during pregnancy is a rare condition with potential life-threatening complications, and management should take into account the fetal impact of the therapeutic choice. We report the case of a 2cm left uterine artery pseudo-aneurysm revealed by pelvic pain, in a 30-year-old pregnant woman at 26(+0)weeks of gestation (WG). Diagnosis was suspected at ultrasound scan, and confirmed with Magnetic Resonance angiography that showed signs of pre-rupture. An emergency selective embolization attempted in utero allowed the complete exclusion of the aneurysmal sac. The patient gave birth one month later to a girl at 31(+1)WG, initially managed by neonatologists, who is currently in good health. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  16. Resultados materno-fetales de la gestación tras cirugía bariátrica Maternal and fetal outcomes in pregnancy following bariatric surgery

    OpenAIRE

    I. González Navarro; J. L. Pereira Cunill; P. Serrano Aguayo; S. Morales Conde; J. M. Martos Martínez; P. P. García Luna

    2011-01-01

    Introducción: La obesidad es la enfermedad metabòlica más frecuente en el mundo y conlleva múltiples co-morbilidades, siendo la cirugía bariátrica (CB) una opción terapéutica cuando fallan las medidas clásicas. La mitad de los pacientes intervenidos son mujeres en edad fértil y está demostrado que la obesidad se asocia a peores resultados obstétricos y fetales. Dado que el estado nutricional se ve afectado por la CB y es un factor esencial para el adecuado desarrollo del embarazo, el objetivo...

  17. [Risk of materno-fetal transmission of the HIV infection with antiretroviral therapy and cesarean section: experience of the Parma group].

    Science.gov (United States)

    Magnani, G; Degli Antoni, A M; Cocca, G; Zoncada, A; Cavatorta, E; Grignaffini, A; Verrotti, C; Soncini, E; Pedicelli, A; Fieni, S; Bussolati, G; Gambini, L; Ndongko, A; Bengalia, G; Dodi, I

    2000-01-01

    Vertical transmission of HIV is by far the most important way of infection in pediatric patients. Transmission rate of infection varies between 15-40% in the absence of antiretroviral prophylaxis. Only 2% of infected pregnant women who underwent caesarean section and zidovudine treatment transmitted the infection to their newborns. From January 1995 to September 2000 twenty seropositive pregnant women and their twenty newborns were followed at the Azienda Ospedaliera of Parma. Nine women (45%) were treated with only zidovudine according to the ACTG 076 protocol; eight women (40%) continued the treatment they were assuming before pregnancy with the eventual addition of zidovudine. 3 women (15%) were not treated because HIV infection was only detected after delivery. 15 women underwent caesarean section, in 13 cases in association to antiretroviral prophylaxis: in the remaining 2 cases no intrapartum treatment was started due to the urgency of delivery. The rate of vertical transmission among the 20 women was 5% (1/20), significantly less then that observed (20.5%) among 31 pregnant HIV women followed in Parma from January 1987 to December 1994 and not treated with antiretroviral prophylaxis and/or cesarean section (Magnani G. Personal data). The only infected baby was born by vaginal delivery. No transmission was observed in the group of pregnant women who underwent the combination of antiretroviral prophylaxis and cesarean section.

  18. Effect of lipid composition of cationic SUV liposomes on materno-fetal transfer of warfarin across the perfused human term placenta.

    Science.gov (United States)

    Bajoria, R; Sooranna, S; Chatterjee, R

    2013-12-01

    Use of drugs that cross the placenta freely are currently avoided during pregnancy. We investigated whether cationic small unilamellar (SUV) liposomes of different lipid compositions could prevent the transfer and uptake of warfarin across human term placenta. Cationic liposomes encapsulated warfarin was prepared by using lecithin (F-SUV) or sterylamine (S-SUV) with cholesterol and stearylamine. The size distribution, encapsulation efficiency, and stability were determined in blood-based media. The transfer kinetics of free and liposomally encapsulated warfarin were studied in a dually perfused isolated lobule of human term placenta with creatinine. Concentrations of warfarin were measured by fluorimetry. Data are expressed as % of initial dose added and given as mean ± sd. Warfarin crossed the placenta freely (14.9 ± 1.1%). Trans placental transfer of warfarin was significantly reduced by F-SUV (6.4 ± 0.6%; P < 0.001) and S-SUV liposomes (5.0 ± 0.8%; P < 0.001). Placental uptake of F-SUV (6.3 ± 1.7%; P < 0.001) was greater than that of S-SUV liposomes (2.2 ± 0.5%; P < 0.001). Our data suggest that cationic liposomes reduce trans placental transfer of warfarin. If confirmed "in vivo", liposomes might provide an alternative non-invasive method of drug delivery to the mother. Copyright © 2013 Elsevier Ltd. All rights reserved.

  19. Hovering and intermittent flight in birds

    International Nuclear Information System (INIS)

    Tobalske, Bret W

    2010-01-01

    Two styles of bird locomotion, hovering and intermittent flight, have great potential to inform future development of autonomous flying vehicles. Hummingbirds are the smallest flying vertebrates, and they are the only birds that can sustain hovering. Their ability to hover is due to their small size, high wingbeat frequency, relatively large margin of mass-specific power available for flight and a suite of anatomical features that include proportionally massive major flight muscles (pectoralis and supracoracoideus) and wing anatomy that enables them to leave their wings extended yet turned over (supinated) during upstroke so that they can generate lift to support their weight. Hummingbirds generate three times more lift during downstroke compared with upstroke, with the disparity due to wing twist during upstroke. Much like insects, hummingbirds exploit unsteady mechanisms during hovering including delayed stall during wing translation that is manifest as a leading-edge vortex (LEV) on the wing and rotational circulation at the end of each half stroke. Intermittent flight is common in small- and medium-sized birds and consists of pauses during which the wings are flexed (bound) or extended (glide). Flap-bounding appears to be an energy-saving style when flying relatively fast, with the production of lift by the body and tail critical to this saving. Flap-gliding is thought to be less costly than continuous flapping during flight at most speeds. Some species are known to shift from flap-gliding at slow speeds to flap-bounding at fast speeds, but there is an upper size limit for the ability to bound (∼0.3 kg) and small birds with rounded wings do not use intermittent glides.

  20. Hovering and intermittent flight in birds

    Energy Technology Data Exchange (ETDEWEB)

    Tobalske, Bret W, E-mail: bret.tobalske@mso.umt.ed [Field Research Station at Fort Missoula, Division of Biological Sciences, University of Montana, Missoula, MT 59812 (United States)

    2010-12-15

    Two styles of bird locomotion, hovering and intermittent flight, have great potential to inform future development of autonomous flying vehicles. Hummingbirds are the smallest flying vertebrates, and they are the only birds that can sustain hovering. Their ability to hover is due to their small size, high wingbeat frequency, relatively large margin of mass-specific power available for flight and a suite of anatomical features that include proportionally massive major flight muscles (pectoralis and supracoracoideus) and wing anatomy that enables them to leave their wings extended yet turned over (supinated) during upstroke so that they can generate lift to support their weight. Hummingbirds generate three times more lift during downstroke compared with upstroke, with the disparity due to wing twist during upstroke. Much like insects, hummingbirds exploit unsteady mechanisms during hovering including delayed stall during wing translation that is manifest as a leading-edge vortex (LEV) on the wing and rotational circulation at the end of each half stroke. Intermittent flight is common in small- and medium-sized birds and consists of pauses during which the wings are flexed (bound) or extended (glide). Flap-bounding appears to be an energy-saving style when flying relatively fast, with the production of lift by the body and tail critical to this saving. Flap-gliding is thought to be less costly than continuous flapping during flight at most speeds. Some species are known to shift from flap-gliding at slow speeds to flap-bounding at fast speeds, but there is an upper size limit for the ability to bound ({approx}0.3 kg) and small birds with rounded wings do not use intermittent glides.

  1. Intermittent oral iron supplementation during pregnancy (Review)

    Science.gov (United States)

    Peña-Rosas, Juan Pablo; De-Regil, Luz Maria; Dowswell, Therese; Viteri, Fernando E

    2014-01-01

    Background Anaemia is a frequent condition during pregnancy, particularly among women from developing countries who have insufficient iron intake to meet increased iron needs of both the mother and the fetus. Traditionally, gestational anaemia has been prevented with the provision of daily iron supplements throughout pregnancy, but adherence to this regimen due to side effects, interrupted supply of the supplements, and concerns about safety among women with an adequate iron intake, have limited the use of this intervention. Intermittent (i.e. one, two or three times a week on non-consecutive days) supplementation with iron alone or in combination with folic acid or other vitamins and minerals has recently been proposed as an alternative to daily supplementation. Objectives To assess the benefits and harms of intermittent supplementation with iron alone or in combination with folic acid or other vitamins and minerals to pregnant women on neonatal and pregnancy outcomes. Search methods We searched the Cochrane Pregnancy and Childbirth Group’s Trials Register (23 March 2012). We also searched the WHO International Clinical Trials Registry Platform (ICTRP) for ongoing studies and contacted relevant organisations for the identification of ongoing and unpublished studies (23 March 2012). Selection criteria Randomised or quasi-randomised trials. Data collection and analysis We assessed the methodological quality of trials using standard Cochrane criteria. Two review authors independently assessed trial eligibility, extracted data and conducted checks for accuracy. Main results This review includes 21 trials from 13 different countries, but only 18 trials (with 4072 women) reported on our outcomes of interest and contributed data to the review. All of these studies compared daily versus intermittent iron supplementation. Three studies provided iron alone, 12 iron+folic acid and three more iron plus multiple vitamins and minerals. Their methodological quality was mixed

  2. Intermittent claudication in a professional rugby player.

    Science.gov (United States)

    Bray, A E; Lewis, W A

    1992-04-01

    Intermittent claudication in a professional rugby player is described. The typical features of a delayed and difficult diagnosis of an external iliac artery stenosis were found. The noninvasive diagnostic protocol used to investigate this young patient with a minimal arterial lesion enabled accurate localization and angioplasty to be performed at the same time as diagnostic angiography. The patient was symptom free with normal arterial pressures on follow-up. It is suggested that appropriate noninvasive investigations should be performed before angiography in young people with minimal lesions.

  3. A stochastic model for intermittent search strategies

    International Nuclear Information System (INIS)

    Benichou, O; Coppey, M; Moreau, M; Suet, P H; Voituriez, R

    2005-01-01

    It is often necessary, in scientific or everyday life problems, to find a randomly hidden target. What is then the optimal strategy to reach it as rapidly as possible? In this article, we develop a stochastic theory for intermittent search behaviours, which are often observed: the searcher alternates phases of intensive search and slow motion with fast displacements. The first results of this theory have already been announced recently. Here we provide a detailed presentation of the theory, as well as the full derivation of the results. Furthermore, we explicitly discuss the minimization of the time needed to find the target

  4. Renewable energies: the cost of intermittency

    International Nuclear Information System (INIS)

    Crassous, Renaud; Roques, Fabien

    2013-01-01

    The authors indicate the different adaptations which will be required for the electric system to cope with the intermittency of solar and wind energy production, and propose an approximate assessment of the associated costs. Different types of adaptation are addressed: secure production in case of absence of wind or sun (electricity imports, construction of additional power stations), use of more flexible production means (gas turbines), grid extensions (connection to offshore production sites, routing of production one part of the country to the other). They think that beyond a 20 per cent share for renewable energies, these costs could rapidly increase

  5. Game performance and intermittent hypoxic training

    OpenAIRE

    Hinckson, E A; Hamlin, M J; Wood, M R; Hopkins, W G

    2007-01-01

    Live high‐train low altitude exposure simulated by hypoxic devices may improve athletic performance. In this study, intermittent normobaric hypoxia was achieved with the GO2altitude® hypoxicator to determine its effects on sea level performance in rugby players. Ten players were randomly assigned to two groups. Players in each group received 14 sessions of either hypoxic (10–15% O2) or normoxic (21% O2) exposure at rest over 14 consecutive days in a single blind fashion. Various performance m...

  6. Intermittent fasting and cardiovascular disease: current evidence and unresolved questions.

    Science.gov (United States)

    Tinsley, Grant M; Horne, Benjamin D

    2018-01-01

    Intermittent fasting has produced a variety of beneficial health effects in animal models, although high-quality research in humans has been limited. This special report examines current evidences for intermittent fasting in humans, discusses issues that require further examination, and recommends new research that can improve the knowledge base in this emerging research area. While potentially useful for health improvement, intermittent fasting requires further study prior to widespread implementation for health purposes. Randomized, longer-term studies are needed to determine whether using intermittent fasting as a lifestyle rather than a diet is feasible and beneficial for the health of some members of the human population.

  7. Adaptive intermittent control: A computational model explaining motor intermittency observed in human behavior.

    Science.gov (United States)

    Sakaguchi, Yutaka; Tanaka, Masato; Inoue, Yasuyuki

    2015-07-01

    It is a fundamental question how our brain performs a given motor task in a real-time fashion with the slow sensorimotor system. Computational theory proposed an influential idea of feed-forward control, but it has mainly treated the case that the movement is ballistic (such as reaching) because the motor commands should be calculated in advance of movement execution. As a possible mechanism for operating feed-forward control in continuous motor tasks (such as target tracking), we propose a control model called "adaptive intermittent control" or "segmented control," that brain adaptively divides the continuous time axis into discrete segments and executes feed-forward control in each segment. The idea of intermittent control has been proposed in the fields of control theory, biological modeling and nonlinear dynamical system. Compared with these previous models, the key of the proposed model is that the system speculatively determines the segmentation based on the future prediction and its uncertainty. The result of computer simulation showed that the proposed model realized faithful visuo-manual tracking with realistic sensorimotor delays and with less computational costs (i.e., with fewer number of segments). Furthermore, it replicated "motor intermittency", that is, intermittent discontinuities commonly observed in human movement trajectories. We discuss that the temporally segmented control is an inevitable strategy for brain which has to achieve a given task with small computational (or cognitive) cost, using a slow control system in an uncertain variable environment, and the motor intermittency is the side-effect of this strategy. Copyright © 2015 Elsevier Ltd. All rights reserved.

  8. Intermittent exotropia: facts, opinions, and unknowns.

    Science.gov (United States)

    Romanchuk, Kenneth G

    2011-01-01

    Intermittent exotropia (IXT) can be a controversial topic, often eliciting lively discussion. This lecture will discuss its definition, incidence, age of onset, presentation, natural variation, criteria for deterioration, goals of treatment, effectiveness of surgical treatment, types of surgical treatment, and unwanted effects of surgical treatment. Results from the scientific literature, opinions of respected colleagues, the opinion of the author, and the results of live polling of the audience during the John Pratt-Johnson lecture are presented. IXT is defined as an exotropia that is present intermittently predominantly for distance. Its incidence is about 1% and it usually has an onset before age 5. Patients often present because of concern regarding the appearance of the eye misalignment. There is natural variation in the control of IXT, the angle of IXT, and the amount of stereopsis. Criteria that denote deterioration are increasing frequency of IXT, progressively and consistently increasing angle of IXT, loss of binocular vision, and increasing concern regarding the patient's appearance and its effect on social interaction. Goals of treatment are to retain equal or nearly equal vision, to obtain acceptable cosmesis, and to retain binocular vision. The long-term success of surgical treatment is not well proven. Persistent postoperative overcorrection is an unwanted effect of surgical treatment. The inherent biologic variation that occurs when measuring the components of IXT makes it difficult to be dogmatic about IXT, particularly when trying to decide when deterioration is occurring.

  9. Chaos as an intermittently forced linear system.

    Science.gov (United States)

    Brunton, Steven L; Brunton, Bingni W; Proctor, Joshua L; Kaiser, Eurika; Kutz, J Nathan

    2017-05-30

    Understanding the interplay of order and disorder in chaos is a central challenge in modern quantitative science. Approximate linear representations of nonlinear dynamics have long been sought, driving considerable interest in Koopman theory. We present a universal, data-driven decomposition of chaos as an intermittently forced linear system. This work combines delay embedding and Koopman theory to decompose chaotic dynamics into a linear model in the leading delay coordinates with forcing by low-energy delay coordinates; this is called the Hankel alternative view of Koopman (HAVOK) analysis. This analysis is applied to the Lorenz system and real-world examples including Earth's magnetic field reversal and measles outbreaks. In each case, forcing statistics are non-Gaussian, with long tails corresponding to rare intermittent forcing that precedes switching and bursting phenomena. The forcing activity demarcates coherent phase space regions where the dynamics are approximately linear from those that are strongly nonlinear.The huge amount of data generated in fields like neuroscience or finance calls for effective strategies that mine data to reveal underlying dynamics. Here Brunton et al.develop a data-driven technique to analyze chaotic systems and predict their dynamics in terms of a forced linear model.

  10. Intermittency Statistics in the Expanding Solar Wind

    Science.gov (United States)

    Cuesta, M. E.; Parashar, T. N.; Matthaeus, W. H.

    2017-12-01

    The solar wind is observed to be turbulent. One of the open questions in solar wind research is how the turbulence evolves as the solar wind expands to great distances. Some studies have focused on evolution of the outer scale but not much has been done to understand how intermittency evolves in the expanding wind beyond 1 AU (see [1,2]). We use magnetic field data from Voyager I spacecraft from 1 to 10AU to study the evolution of statistics of magnetic discontinuities. We perform various statistical tests on these discontinuities and make connections to the physical processes occurring in the expanding wind.[1] Tsurutani, Bruce T., and Edward J. Smith. "Interplanetary discontinuities: Temporal variations and the radial gradient from 1 to 8.5 AU." Journal of Geophysical Research: Space Physics 84.A6 (1979): 2773-2787.[2] Greco, A., et al. "Evidence for nonlinear development of magnetohydrodynamic scale intermittency in the inner heliosphere." The Astrophysical Journal 749.2 (2012): 105.

  11. Fluorescence intermittency in single cadmium selenide nanocrystals

    Science.gov (United States)

    Nirmal, M.; Dabbousi, B. O.; Bawendi, M. G.; Macklin, J. J.; Trautman, J. K.; Harris, T. D.; Brus, L. E.

    1996-10-01

    SEMICONDUCTOR nanocrystals offer the opportunity to study the evolution of bulk materials properties as the size of a system increases from the molecular scale1,2. In addition, their strongly size-dependent optical properties render them attractive candidates as tunable light absorbers and emitters in optoelectronic devices such as light-emitting diodes3,4 and quantum-dot lasers5,6, and as optical probes of biological systems7. Here we show that light emission from single fluorescing nanocrystals of cadmium selenide under continuous excitation turns on and off intermittently with a characteristic timescale of about 0.5 seconds. This intermittency is not apparent from ensemble measurements on many nanocrystals. The dependence on excitation intensity and the change in on/off times when a passivating, high-bandgap shell of zinc sulphide encapsulates the nanocrystal8,9 suggests that the abrupt turning off of luminescence is caused by photo-ionization of the nanocrystal. Thus spectroscopic measurements on single nanocrystals can reveal hitherto unknown aspects of their photophysics.

  12. Impact of intermittent fasting on glucose homeostasis.

    Science.gov (United States)

    Varady, Krista A

    2016-07-01

    This article provides an overview of the most recent human trials that have examined the impact of intermittent fasting on glucose homeostasis. Our literature search retrieved one human trial of alternate day fasting, and three trials of Ramadan fasting published in the past 12 months. Current evidence suggests that 8 weeks of alternate day fasting that produces mild weight loss (4% from baseline) has no effect on glucose homeostasis. As for Ramadan fasting, decreases in fasting glucose, insulin, and insulin resistance have been noted after 4 weeks in healthy normal weight individuals with mild weight loss (1-2% from baseline). However, Ramadan fasting may have little impact on glucoregulatory parameters in women with polycystic ovarian syndrome who failed to observe weight loss. Whether intermittent fasting is an effective means of regulating glucose homeostasis remains unclear because of the scarcity of studies in this area. Large-scale, longer-term randomized controlled trials will be required before the use of fasting can be recommended for the prevention and treatment of metabolic diseases.

  13. Intermittent preventive treatment of malaria in pregnancy

    DEFF Research Database (Denmark)

    Mbonye, A.K.; Bygbjerg, Ib Christian; Magnussen, Pascal

    2008-01-01

    OBJECTIVE: To assess whether traditional birth attendants, drug-shop vendors, community reproductive-health workers, or adolescent peer mobilizers could administer intermittent preventive treatment (IPTp) for malaria with sulfadoxine-pyrimethamine to pregnant women. METHODS: A non-randomized comm......OBJECTIVE: To assess whether traditional birth attendants, drug-shop vendors, community reproductive-health workers, or adolescent peer mobilizers could administer intermittent preventive treatment (IPTp) for malaria with sulfadoxine-pyrimethamine to pregnant women. METHODS: A non......-randomized community trial was implemented in 21 community clusters (intervention) and four clusters where health units provided routine IPTp (control). The primary outcome measures were access and adherence to IPTp, number of malaria episodes, prevalence of anaemia, and birth weight. Numbers of live births, abortions......, still births, and maternal and child deaths were secondary endpoints. FINDINGS: 1404 (67.5%) of 2081 with the new delivery system received two doses of sulfadoxine-pyrimethamine versus 281 (39.9%) of 704 with health units (P malaria episodes decreased from 906 (49...

  14. Game performance and intermittent hypoxic training

    Science.gov (United States)

    Hinckson, E A; Hamlin, M J; Wood, M R; Hopkins, W G

    2007-01-01

    Live high‐train low altitude exposure simulated by hypoxic devices may improve athletic performance. In this study, intermittent normobaric hypoxia was achieved with the GO2altitude® hypoxicator to determine its effects on sea level performance in rugby players. Ten players were randomly assigned to two groups. Players in each group received 14 sessions of either hypoxic (10–15% O2) or normoxic (21% O2) exposure at rest over 14 consecutive days in a single blind fashion. Various performance measures were obtained consecutively in a single testing session pre‐ and post‐exposure. Effects of hypoxic exposure on maximum speed and sprint times were trivial (<1.0%) but unclear (90% likely range, ±5% to ±9%). In rugby simulation, hypoxic exposure produced impairments of peak power in two scrums (15%, ±8%; 9%, ±7%) and impairments of time in offensive sprints (7%, ±8%) and tackle sprints (11%, ±9%). Pending further research, rugby players would be unwise to use normobaric intermittent hypoxic exposure to prepare for games at sea level. PMID:17311807

  15. Modes of exercise training for intermittent claudication.

    Science.gov (United States)

    Lauret, Gert Jan; Fakhry, Farzin; Fokkenrood, Hugo J P; Hunink, M G Myriam; Teijink, Joep A W; Spronk, Sandra

    2014-07-04

    According to international guidelines and literature, all patients with intermittent claudication should receive an initial treatment of cardiovascular risk modification, lifestyle coaching, and supervised exercise therapy. In most studies, supervised exercise therapy consists of treadmill or track walking. However, alternative modes of exercise therapy have been described and yielded similar results to walking. Therefore, the following question remains: Which exercise mode gives the most beneficial results? To assess the effects of different modes of supervised exercise therapy on the maximum walking distance (MWD) of patients with intermittent claudication. To assess the effects of different modes of supervised exercise therapy on pain-free walking distance (PFWD) and health-related quality of life scores (HR-QoL) of patients with intermittent claudication. The Cochrane Peripheral Vascular Diseases Group Trials Search Co-ordinator searched the Cochrane Peripheral Vascular Diseases Group Specialised Register (July 2013); CENTRAL (2013, Issue 6), in The Cochrane Lib rary; and clinical trials databases. The authors searched the MEDLINE (1946 to July 2013) and Embase (1973 to July 2013) databases and reviewed the reference lists of identified articles to detect other relevant citations. Randomised controlled trials of studies comparing alternative modes of exercise training or combinations of exercise modes with a control group of supervised walking exercise in patients with clinically determined intermittent claudication. The supervised walking programme needed to be supervised at least twice a week for a consecutive six weeks of training. Two authors independently selected studies, extracted data, and assessed the risk of bias for each study. Because of different treadmill test protocols to assess the maximum or pain-free walking distance, we converted all distances or walking times to total metabolic equivalents (METs) using the American College of Sports Medicine

  16. Acute Effects of Carbohydrate Supplementation on Intermittent Sports Performance

    Directory of Open Access Journals (Sweden)

    Lindsay B. Baker

    2015-07-01

    Full Text Available Intermittent sports (e.g., team sports are diverse in their rules and regulations but similar in the pattern of play; that is, intermittent high-intensity movements and the execution of sport-specific skills over a prolonged period of time (~1–2 h. Performance during intermittent sports is dependent upon a combination of anaerobic and aerobic energy systems, both of which rely on muscle glycogen and/or blood glucose as an important substrate for energy production. The aims of this paper are to review: (1 potential biological mechanisms by which carbohydrate may impact intermittent sport performance; (2 the acute effects of carbohydrate ingestion on intermittent sport performance, including intermittent high-intensity exercise capacity, sprinting, jumping, skill, change of direction speed, and cognition; and (3 what recommendations can be derived for carbohydrate intake before/during exercise in intermittent sports based on the available evidence. The most researched intermittent sport is soccer but some sport-specific studies have also been conducted in other sports (e.g., rugby, field hockey, basketball, American football, and racquet sports. Carbohydrate ingestion before/during exercise has been shown in most studies to enhance intermittent high-intensity exercise capacity. However, studies have shown mixed results with regards to the acute effects of carbohydrate intake on sprinting, jumping, skill, change of direction speed, and cognition. In most of these studies the amount of carbohydrate consumed was ~30–60 g/h in the form of a 6%–7% carbohydrate solution comprised of sucrose, glucose, and/or maltodextrin. The magnitude of the impact that carbohydrate ingestion has on intermittent sport performance is likely dependent on the carbohydrate status of the individual; that is, carbohydrate ingestion has the greatest impact on performance under circumstances eliciting fatigue and/or hypoglycemia. Accordingly, carbohydrate ingestion before

  17. Acute Effects of Carbohydrate Supplementation on Intermittent Sports Performance.

    Science.gov (United States)

    Baker, Lindsay B; Rollo, Ian; Stein, Kimberly W; Jeukendrup, Asker E

    2015-07-14

    Intermittent sports (e.g., team sports) are diverse in their rules and regulations but similar in the pattern of play; that is, intermittent high-intensity movements and the execution of sport-specific skills over a prolonged period of time (~1-2 h). Performance during intermittent sports is dependent upon a combination of anaerobic and aerobic energy systems, both of which rely on muscle glycogen and/or blood glucose as an important substrate for energy production. The aims of this paper are to review: (1) potential biological mechanisms by which carbohydrate may impact intermittent sport performance; (2) the acute effects of carbohydrate ingestion on intermittent sport performance, including intermittent high-intensity exercise capacity, sprinting, jumping, skill, change of direction speed, and cognition; and (3) what recommendations can be derived for carbohydrate intake before/during exercise in intermittent sports based on the available evidence. The most researched intermittent sport is soccer but some sport-specific studies have also been conducted in other sports (e.g., rugby, field hockey, basketball, American football, and racquet sports). Carbohydrate ingestion before/during exercise has been shown in most studies to enhance intermittent high-intensity exercise capacity. However, studies have shown mixed results with regards to the acute effects of carbohydrate intake on sprinting, jumping, skill, change of direction speed, and cognition. In most of these studies the amount of carbohydrate consumed was ~30-60 g/h in the form of a 6%-7% carbohydrate solution comprised of sucrose, glucose, and/or maltodextrin. The magnitude of the impact that carbohydrate ingestion has on intermittent sport performance is likely dependent on the carbohydrate status of the individual; that is, carbohydrate ingestion has the greatest impact on performance under circumstances eliciting fatigue and/or hypoglycemia. Accordingly, carbohydrate ingestion before and during a game

  18. Acute Effects of Carbohydrate Supplementation on Intermittent Sports Performance

    Science.gov (United States)

    Baker, Lindsay B.; Rollo, Ian; Stein, Kimberly W.; Jeukendrup, Asker E.

    2015-01-01

    Intermittent sports (e.g., team sports) are diverse in their rules and regulations but similar in the pattern of play; that is, intermittent high-intensity movements and the execution of sport-specific skills over a prolonged period of time (~1–2 h). Performance during intermittent sports is dependent upon a combination of anaerobic and aerobic energy systems, both of which rely on muscle glycogen and/or blood glucose as an important substrate for energy production. The aims of this paper are to review: (1) potential biological mechanisms by which carbohydrate may impact intermittent sport performance; (2) the acute effects of carbohydrate ingestion on intermittent sport performance, including intermittent high-intensity exercise capacity, sprinting, jumping, skill, change of direction speed, and cognition; and (3) what recommendations can be derived for carbohydrate intake before/during exercise in intermittent sports based on the available evidence. The most researched intermittent sport is soccer but some sport-specific studies have also been conducted in other sports (e.g., rugby, field hockey, basketball, American football, and racquet sports). Carbohydrate ingestion before/during exercise has been shown in most studies to enhance intermittent high-intensity exercise capacity. However, studies have shown mixed results with regards to the acute effects of carbohydrate intake on sprinting, jumping, skill, change of direction speed, and cognition. In most of these studies the amount of carbohydrate consumed was ~30–60 g/h in the form of a 6%–7% carbohydrate solution comprised of sucrose, glucose, and/or maltodextrin. The magnitude of the impact that carbohydrate ingestion has on intermittent sport performance is likely dependent on the carbohydrate status of the individual; that is, carbohydrate ingestion has the greatest impact on performance under circumstances eliciting fatigue and/or hypoglycemia. Accordingly, carbohydrate ingestion before and during a

  19. Bound by Children: Intermittent Cohabitation and Living Together Apart

    Science.gov (United States)

    Cross-Barnet, Caitlin; Cherlin, Andrew; Burton, Linda

    2011-01-01

    In this article, we examine variations in low-income mothers' patterns of intermittent cohabitation and the voluntary and involuntary nature of these unions. Intermittent cohabitation involves couples living together and separating in repeating cycles. Using Three-City Study ethnographic data, we identified 45 low-income mothers involved in these…

  20. Intermittent Testicular Torsion | Obi | Nigerian Journal of Clinical ...

    African Journals Online (AJOL)

    Methods: Clinical and demographic data of all patients treated for intermittent testicular torsion from January 2007 to June 2015 were prospectively collected in a pro forma and analyzed. A diagnosis of intermittent torsion was made on the basis of recurrent scrotal pain, presence of abnormal testicular lie in otherwise normal ...

  1. 21 CFR 868.5955 - Intermittent mandatory ventilation attachment.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Intermittent mandatory ventilation attachment. 868.5955 Section 868.5955 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Therapeutic Devices § 868.5955 Intermittent mandatory ventilation attachment. (a)...

  2. Acute intermittent porphyria: Diagnosis per chance

    Directory of Open Access Journals (Sweden)

    Soundravally R

    2008-10-01

    Full Text Available Objectives: To report a case of acute intermittent porphyria (AIP diagnosed by chance during routine investigations. Clinical Presentation and Intervention: A 21-year-old female presented with vague gastrointestinal symptoms. Upon admission, she was disoriented. Later she developed generalized seizures and was treated with phenytoin, but the condition worsened. Upon investigation, her liver function, renal function, blood sugar level and electrolytes were within normal limits. When kept for routine laboratory testing, the color change in urine prompted us to investigate for porphyria. It was positive for phorphobilinogen (PBG and urophorphyrin. Since AIP had been diagnosed, the initial treatment with phenytoin was discontinued with a favorable outcome. A screening test for PBG in urine by Ehrlich′s reagent was performed on the patient′s mother and was positive. Conclusion: A high degree of suspicion at the laboratory can also determine the diagnosis of AIP, which is often missed by the clinician.

  3. Intermittent hypoxia and cancer: Undesirable bed partners?

    Science.gov (United States)

    Almendros, Isaac; Gozal, David

    2017-08-14

    The deleterious effects of intermittent hypoxia (IH) on cancer biology have been primarily evaluated in the context of the aberrant circulation observed in solid tumors which results in recurrent intra-tumoral episodic hypoxia. From those studies, IH has been linked to an accelerated tumor progression, metastasis and resistance to therapies. More recently, the role of IH in cancer has also been studied in the context of obstructive sleep apnea (OSA), since IH is a hallmark characteristic of this condition. Such recent studies are undoubtedly adding more information regarding the role of IH on tumor malignancy. In terms of the IH patterns associated with OSA, this altered oxygenation paradigm has been recently proposed as a determinant factor in fostering cancer incidence and progression from both in vitro and in vivo experimental models. Here, we summarize all the available evidence to date linking IH effects on several types of cancer. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Towards an intermittency-friendly energy system

    DEFF Research Database (Denmark)

    Blarke, Morten

    2012-01-01

    are capitulating as wind power penetration levels are moving above 25%; some operators are retiring cogeneration units entirely, while other operators are making way for heat-only boilers. This development is jeopardizing the system-wide energy, economic, and environmental benefits that distributed cogeneration...... still has to offer. The solution is for distributed operators to adapt their technology and operational strategies to achieve a better co-existence between cogeneration and wind power. Four options for doing so are analysed including a new concept that integrates a high pressure compression heat pump......Distributed cogeneration has played a key role in the implementation of sustainable energy policies for three decades. However, increasing penetration levels of intermittent renewables is challenging that position. The paradigmatic case of West Denmark indicates that distributed operators...

  5. Compensatory mechanisms activated with intermittent energy restriction

    DEFF Research Database (Denmark)

    Coutinho, Sílvia Ribeiro; Halset, Eline Holli; Gåsbakk, Sigrid

    2017-01-01

    Background & aims: Strong compensatory responses, with reduced resting metabolic rate (RMR), increased exercise efficiency (ExEff) and appetite, are activated when weight loss (WL) is achieved with continuous energy restriction (CER), which try to restore energy balance. Intermittent energy......: 39 ± 9 y) with obesity (BMI: 36 ± 4 kg/m2) were randomized to lose a similar weight with an IER (N = 18) or a CER (N = 17) diet over a 12 week period. Macronutrient composition and overall energy restriction (33% reduction) were similar between groups. Body weight/composition, RMR, fasting......) were measured before and after WL. Results: Changes in body weight (≈12.5% WL) and composition were similar in both groups. Fasting RQ and ExEff at 10 W increased in both groups. Losing weight, either by IER or CER dieting, did not induce significant changes in subjective appetite ratings. RMR...

  6. Beneficial effects of intermittent suction and pressure treatment in intermittent claudication

    DEFF Research Database (Denmark)

    Mehlsen, J; Himmelstrup, H; Himmelstrup, Bodil

    1993-01-01

    The present study reports on the effects of a physical treatment modality in patients with intermittent claudication. During this treatment a major part of the skin surface is subjected to intermittent suction and pressure. In a previous, preliminary study the authors found a beneficial effect...... participated in an open trial investigating the possible effects of the treatment on platelet aggregation and fibrinolysis. Pain-free and maximal walking distances were measured on a treadmill, and systolic blood pressure was measured on the upper limb, the ankle, and the first toe bilaterally. The threshold...... for adenosine diphosphate (ADP)-induced platelet aggregation was tested, and the fibrinolytic activity was estimated from the euglobulin clot lysis time. Active treatment resulted in significant improvements in pain-free and maximal walking distances, whereas no changes could be found during placebo...

  7. Secret Underlying Unexplained Abdominal Pain, Neurological Symptoms and Intermittent Hypertension: Acute Intermittent Porphyria

    Directory of Open Access Journals (Sweden)

    Komac Andac

    2017-06-01

    Full Text Available A 21-year-old female patient with abdominal pain, vomiting and constipation was admitted to the hospital with the possible diagnosis of diabetic ketoacidosis. Due to increased abdominal pain and constipation the patient underwent a surgery with the diagnosis of ileus. However, no pathological findings were found in the abdominal organs apart from serous fluid in the abdominal cavity. The patient became hypertensive, tachycardic and had an episode of seizures postoperatively. Neurological manifestations with unexplained abdominal pain indicated a diagnosis of acute intermittent porphyria (AIP. Acute intermittent porphyria diagnosis is based on elevated urinary δ-aminolevulinic acid (ALA and porphobilinogen (PBG levels as well as hydroxymethylbilane synthase (HMBS IVS13-2 A>G heterozygous mutation. Familial Mediterranean Fever (FMF gene mutations were not confirmed. Porphyria should be considered in the differential diagnosis of patients with recurrent abdominal pain, neurological symptoms and lack of FMF gene polymorphism.

  8. Cost effectiveness of intermittent screening followed by treatment versus intermittent preventive treatment during pregnancy in West Africa

    DEFF Research Database (Denmark)

    Fernandes, Silke; Sicuri, Elisa; Halimatou, Diawara

    2016-01-01

    Background: Emergence of high-grade sulfadoxine-pyrimethamine (SP) resistance in parts of Africa has led to growing concerns about the efficacy of intermittent preventive treatment of malaria during pregnancy (IPTp) with SP. The incremental cost-effectiveness of intermittent screening and treatme...

  9. Intermittent intravenous followed by intermittent oral 1 alpha(OH)D3 treatment of secondary hyperparathyroidism in uraemia

    DEFF Research Database (Denmark)

    Brandi, L; Daugaard, H; Egsmose, C

    1996-01-01

    OBJECTIVES: To examine whether intermittent oral 1 alpha(OH)D3 treatment of patients on haemodialysis with secondary hyperparathyroidism (HPT) was able to maintain the marked suppression of PTH, which previously had been induced by an intermittent intravenous administration of 1 alpha(OH)D3...

  10. Intermittent drinking, oxytocin and human health.

    Science.gov (United States)

    Pruimboom, L; Reheis, D

    2016-07-01

    Looking at a waterhole, it is surprising that so many animals share the same space without visible signs of anxiety or aggression. Although waterholes are the preferred feeding locations of large carnivores, waterholes are shared by all type of herbivores of all sizes and shapes, including elephants. Recent research shows that the homeostatic disturbances leading to the "thirst feeling" not only activate specific substances regulating water and mineral household, but also the "trust and love" hormone oxytocin, while decreasing the production of the typical stress hormone cortisol. People using drugs, seem to be in search for oxytocin, as evidenced in studies with individuals on drugs such as ecstasy and gamma-hydroxybyturate. Hot environment, drought and increased sweating also activate specific oxytocin-producing parts of the hypothalamus, just as breastfeeding does in mother and infant. Water homeostasis is the only allostatic system activating trust neuro-anatomy and we suggest that this is due to the fact that all animals depend on water, whereas food type is species specific. Our hypothesis; regulating drinking behaviour through intermittent bulk drinking could increase oxytocin signalling, recover human trust and increase health by down-regulation of stress axis activity and inflammatory activity of the immune system. Intermittent bulk drinking should be defined as water (including tea and coffee) drinking up to a feeling of satiety and regulated by a mild feeling of thirst. This would mean that people would not drink less quantity but less frequently and that's how all animals, but also human newborns behave. It is the latter group, which is probably the only group of humans with a normal fluid homeostasis. Copyright © 2016 Elsevier Ltd. All rights reserved.

  11. [Intermittent Explosive Disorder: A Controversial Diagnosis].

    Science.gov (United States)

    Zapata, Juan Pablo; Palacio, Juan David

    2016-01-01

    Intermittent explosive disorder (IED) is aan externalizing externalising disorder characterized characterised by recurrent aggression episodes. Even though this disorder was described several decades ago, and it carries personal and social consequences, there is little in the medical scientific literature on this. bibliographic production about it is scanty. To perform a conceptualization conceptualisation of this disorder, through the review and bibliometric analysis of the available scientific articles. A search was performed in databases with the english English terms intermittent explosive disorder, impulse disorders control [MeSH], in combination with other terms. A bibliometric analysis in the GoPubMed® search engineer was also performed using all data obtained in the search. was also perfomed. IED prevalence ranges from 1.4% to 7%, it presents more frequently during middle adolescence, and with more noticeable repercussions in men males than in womenfemales. The psychopathological core of IED is the impulsive aggressive behaviour that presents in the form of «attacks» that occurs in response to a lower precipitating stimulus. Scientific publications about IED are few and relatively recent, and the vast majority is provided bycomes from the United States (56.56%), and headed by a single author. This fact highlights the need to replicate the findings described about the IED in order to demonstrate the validity and reliability of its diagnostic criteria. It is possible that doubts about the existence of a diagnosis lead have led to such a scant literature about the IED. Available studies about IED allow have allowed characterizing a group of subjects with episodes of impulsive aggression to be characterised, but this description requires replication in different latitudesneeds to be repeated in different areas. Copyright © 2015 Asociación Colombiana de Psiquiatría. Publicado por Elsevier España. All rights reserved.

  12. Squinting and photophobia in intermittent exotropia.

    Science.gov (United States)

    Oh, Baek-Lok; Suh, Soh-Youn; Choung, Ho-Kyung; Kim, Seong-Joon

    2014-05-01

    To report factors associated with preoperative squinting, defined as transient eye closure in bright light, and photophobia and the factors affecting improvement of these symptoms postoperatively in intermittent exotropia. In this retrospective study, patients (N = 99) were divided into groups according to the presence (n = 54) or absence (n = 45) of preoperative squinting and the presence (n = 64) or absence (n = 35) of photophobia. Clinical characteristics, including overaction or underaction of the oblique muscle and fundus intorsion and extorsion, were compared between the two groups. The squinting and photophobia groups were further categorized into two subgroups each according to postoperative improvement. The extended list of characteristics, including the duration from onset to surgery, postoperative angle of deviation, and fusion, was compared between the two subgroups. Preoperatively, 54 (54.5%) and 64 (64.6%) patients had squinting and photophobia, respectively. The coincidence of squinting and photophobia was marginally significant (p = 0.05). Postoperatively, squinting and photophobia disappeared in 64.8 and 59.4% of the patients, respectively. The photophobia group had a younger onset age of strabismus than the nonphotophobia group (39.3 vs. 56.4 months; p = 0.03). Good fusional status at the near range was more common in the nonsquinting group than in the squinting group (74.3 vs. 47.6%; p = 0.02). Superior oblique overaction was significantly more common in the squinting group than in the nonsquinting group (11.1 vs. 0%; p = 0.03). Early surgical correction and successful outcomes were associated with squinting improvement (p = 0.001 and p = 0.02, respectively). More than 50% of patients with intermittent exotropia had squinting or photophobia, and approximately 60% of symptomatic patients experienced improvement postoperatively. The onset of strabismus, near fusion, superior oblique overaction, and fundus intorsion were related to these symptoms

  13. Managing server clusters on intermittent power

    Directory of Open Access Journals (Sweden)

    Navin Sharma

    2015-12-01

    Full Text Available Reducing the energy footprint of data centers continues to receive significant attention due to both its financial and environmental impact. There are numerous methods that limit the impact of both factors, such as expanding the use of renewable energy or participating in automated demand-response programs. To take advantage of these methods, servers and applications must gracefully handle intermittent constraints in their power supply. In this paper, we propose blinking—metered transitions between a high-power active state and a low-power inactive state—as the primary abstraction for conforming to intermittent power constraints. We design Blink, an application-independent hardware–software platform for developing and evaluating blinking applications, and define multiple types of blinking policies. We then use Blink to design both a blinking version of memcached (BlinkCache and a multimedia cache (GreenCache to demonstrate how application characteristics affect the design of blink-aware distributed applications. Our results show that for BlinkCache, a load-proportional blinking policy combines the advantages of both activation and synchronous blinking for realistic Zipf-like popularity distributions and wind/solar power signals by achieving near optimal hit rates (within 15% of an activation policy, while also providing fairer access to the cache (within 2% of a synchronous policy for equally popular objects. In contrast, for GreenCache, due to multimedia workload patterns, we find that a staggered load proportional blinking policy with replication of the first chunk of each video reduces the buffering time at all power levels, as compared to activation or load-proportional blinking policies.

  14. Enhancement of Intermittent Androgen Ablation Therapy by Finasteride Administration in Animal Models

    National Research Council Canada - National Science Library

    Wang, Zhou

    2003-01-01

    .... Intermittent androgen ablation therapy may slow down the development of androgen refractory tumors because intermittent recovery of androgens can induce differentiation of prostatic epithelial cells...

  15. Enhancement of Intermittent Androgen Ablation Therapy by Finasteride Administration in Animal Models

    National Research Council Canada - National Science Library

    Wang, Zhou

    2005-01-01

    .... Intermittent androgen ablation therapy may slow down the development of androgen refractory tumors because intermittent recovery of androgens can induce differentiation of prostatic epithelial cells...

  16. Enhancement of Intermittent Androgen Ablation Therapy by Finasteride Administration in Animal Models

    National Research Council Canada - National Science Library

    Wang, Zhou

    2006-01-01

    .... Intermittent androgen ablation therapy (IAAT) may slow down the development of androgen refractory tumors because intermittent recovery of androgens can induce differentiation of prostatic epithelial cells...

  17. Enhancement of Intermittent Androgen Ablation Therapy by Finasteride Administration in Animal Models

    National Research Council Canada - National Science Library

    Wang, Zhou

    2004-01-01

    .... Intermittent androgen ablation therapy may slow down the development of androgen refractory tumors because intermittent recovery of androgens can induce differentiation of prostatic epithelial cells...

  18. Mixing and diffusion in intermittent overturning turbulence

    Science.gov (United States)

    Redondo, Jose M.; Mahjoub, Otman B.; Gonzalez-Nieto, Pilar L.; Lawry, Andrew

    2014-05-01

    The improvements in experimental methods and high resolution image analysis are nowadays able to detect subtle changes in the structure of the turbulence over a wide range of temporal and spatial scales [1], we compare the scaling shown by different mixing fronts driven by buoyancy that form a Rayleigh-Taylor mixing front. We use PIV and density front tracking in several experimental configurations akin to geophysical overturning [2-7]. We parametrize the role of unstable stratification by means of the Atwood number and compare both the scaling and the multifractal and the maximum local fractal structure functions of the different markers used to visualize the front. Both reactive and passive scalar tracers are used to investigate the mixing structure and the intermittency of the flow. Different initial conditions are compared and the mixing efficiency of the overal turbulent process evaluated [6-7]. An interesting approach, relating the Multi-Fractal dimension spectra, the intermittency and the spectral exponent is to find relationships that may be used to parameterise the sub-grid turbulence in terms of generalized diffusivities [4 ] that take into account the topology and the self-similarity of the Mixing RT and RM flows. As an example, a relationship between the diffusivity, the exponent β, the intermittency μ, and D(i), may be found for the volume fraction or the concentration, at the same time other locally measured parameters such as the enstrophy or the gradient alignment as well as their multi-fractal structures may turn out to be physically relevant indicators of the local turbulence and the mixing. Several methods of deriving local eddy diffusivity and local entrainment should give more realistic estimates of the spatial/temporal non-homogeneities (and intermittencies in the Kolmogorov 62 sense obtained as spatial correlations of the turbulent dissipation, or from structure functions) and these values may be used to parameterise turbulence at a variety

  19. Intermittent fasting: a "new" historical strategy for controlling seizures?

    Science.gov (United States)

    Hartman, Adam L; Rubenstein, James E; Kossoff, Eric H

    2013-05-01

    In antiquity, fasting was a treatment for epilepsy and a rationale for the ketogenic diet (KD). Preclinical data indicate the KD and intermittent fasting do not share identical anticonvulsant mechanisms. We implemented an intermittent fasting regimen in six children with an incomplete response to a KD. Three patients adhered to the combined intermittent fasting/KD regimen for 2 months and four had transient improvement in seizure control, albeit with some hunger-related adverse reactions. Copyright © 2012 Elsevier B.V. All rights reserved.

  20. Photoluminescence intermittency of semiconductor quantum dots in dielectric environments

    Energy Technology Data Exchange (ETDEWEB)

    Isaac, A.

    2006-08-11

    The experimental studies presented in this thesis deal with the photoluminescence intermittency of semiconductor quantum dots in different dielectric environments. Detailed analysis of intermittency statistics from single capped CdSe/ZnS, uncapped CdSe and water dispersed CdSe/ZnS QDs in different matrices provide experimental evidence for the model of photoionization with a charge ejected into the surrounding matrix as the source of PL intermittency phenomenon. We propose a self-trapping model to explain the increase of dark state lifetimes with the dielectric constant of the matrix. (orig.)

  1. Acute Effects of Carbohydrate Supplementation on Intermittent Sports Performance

    OpenAIRE

    Baker, Lindsay B.; Rollo, Ian; Stein, Kimberly W.; Jeukendrup, Asker E.

    2015-01-01

    Intermittent sports (e.g., team sports) are diverse in their rules and regulations but similar in the pattern of play; that is, intermittent high-intensity movements and the execution of sport-specific skills over a prolonged period of time (~1–2 h). Performance during intermittent sports is dependent upon a combination of anaerobic and aerobic energy systems, both of which rely on muscle glycogen and/or blood glucose as an important substrate for energy production. The aims of this paper are...

  2. Valvoplastia aórtica por cateter-balão em emergência materno-fetal na adolescência Valvuloplastia aórtica por catéter con balón en emergencia materno-fetal en la adolescencia Aortic valvuloplasty with balloon catheter in maternal-fetal emergency in adolescence

    Directory of Open Access Journals (Sweden)

    Walkiria Samuel Avila

    2009-12-01

    Full Text Available O aumento do débito cardíaco durante a gravidez é causa de insuficiência cardíaca em portadoras de estenose valvar aórtica grave. A valvoplastia aórtica percutânea tem sido associada a graves complicações e reestenose valvar em curto prazo. O presente caso mostrou que a valvoplastia aórtica percutânea permitiu o alcance do parto com sobrevida da mãe e do feto, e que a interrupção do tratamento no pós-parto resultou em morte materna no puerpério tardio.El aumento del gasto cardiaco durante el embarazo es la causa de insuficiencia cardiaca en portadoras de estenosis valvular aórtica severa. Se viene asociando la valvuloplastia aórtica percutánea a severas complicaciones y reestenosis valvular en corto plazo. El presente caso reveló que la valvuloplastia aórtica percutánea permitió el alcance del parto con sobrevida de la madre y del feto, y que la interrupción del tratamiento en el postparto resultó en muerte materna en el puerperio tardío.The increase of cardiac output during pregnancy is the cause of heart failure in women with severe aortic valvular stenosis. Percutaneous aortic valvuloplasty has been associated with severe complications and short-term valvar restenosis. This case showed that percutaneous aortic valvuloplasty allowed both mother and fetus to survive after childbirth, and that postpartum treatment interruption resulted in maternal death in late postpartum care.

  3. Intermittent Renewable Management Pilot Phase 2

    Energy Technology Data Exchange (ETDEWEB)

    Kiliccote, Sila [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Homan, Gregory [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Anderson, Robert [Olivine, Inc., San Ramon, CA (United States); Hernandez, John [Pacific Gas & Electric Company, San Francisco, CA (United States)

    2015-04-01

    The Intermittent Renewable Management Pilot - Phase 2 (IRM2) was designed to study the feasibility of demand-side resources to participate into the California Independent System Operator (CAISO) wholesale market as proxy demand resources (PDR). The pilot study focused on understanding the issues related with direct participation of third-parties and customers including customer acceptance; market transformation challenges (wholesale market, technology); technical and operational feasibility; and value to the rate payers, DR resource owners and the utility on providing an enabling mechanism for DR resources into the wholesale markets. The customer had the option of committing to either three contiguous hour blocks for 24 days or six contiguous hours for 12 days a month with day-ahead notification that aligned with the CAISO integrated forward market. As a result of their being available, the customer was paid $10/ kilowatt (kW)-month for capacity in addition to CAISO energy settlements. The participants were limited to no more than a 2 megawatt (MW) capacity with a six-month commitment. Four participants successfully engaged in the pilot. In this report, we provide the description of the pilot, participant performance results, costs and value to participants as well as outline some of the issues encountered through the pilot. Results show that participants chose to participate with storage and the value of CAISO settlements were significantly lower than the capacity payments provided by the utility as incentive payments. In addition, this pilot revealed issues both on the participant side and system operations side. These issues are summarized in the report.The Intermittent Renewable Management Pilot - Phase 2 (IRM2) was designed to study the feasibility of demand-side resources to participate into the California Independent System Operator (CAISO) wholesale market as proxy demand resources (PDR). The pilot study focused on understanding the issues related with

  4. Long-range forecasting of intermittent streamflow

    Science.gov (United States)

    van Ogtrop, F. F.; Vervoort, R. W.; Heller, G. Z.; Stasinopoulos, D. M.; Rigby, R. A.

    2011-11-01

    Long-range forecasting of intermittent streamflow in semi-arid Australia poses a number of major challenges. One of the challenges relates to modelling zero, skewed, non-stationary, and non-linear data. To address this, a statistical model to forecast streamflow up to 12 months ahead is applied to five semi-arid catchments in South Western Queensland. The model uses logistic regression through Generalised Additive Models for Location, Scale and Shape (GAMLSS) to determine the probability of flow occurring in any of the systems. We then use the same regression framework in combination with a right-skewed distribution, the Box-Cox t distribution, to model the intensity (depth) of the non-zero streamflows. Time, seasonality and climate indices, describing the Pacific and Indian Ocean sea surface temperatures, are tested as covariates in the GAMLSS model to make probabilistic 6 and 12-month forecasts of the occurrence and intensity of streamflow. The output reveals that in the study region the occurrence and variability of flow is driven by sea surface temperatures and therefore forecasts can be made with some skill.

  5. Long-range forecasting of intermittent streamflow

    Directory of Open Access Journals (Sweden)

    F. F. van Ogtrop

    2011-11-01

    Full Text Available Long-range forecasting of intermittent streamflow in semi-arid Australia poses a number of major challenges. One of the challenges relates to modelling zero, skewed, non-stationary, and non-linear data. To address this, a statistical model to forecast streamflow up to 12 months ahead is applied to five semi-arid catchments in South Western Queensland. The model uses logistic regression through Generalised Additive Models for Location, Scale and Shape (GAMLSS to determine the probability of flow occurring in any of the systems. We then use the same regression framework in combination with a right-skewed distribution, the Box-Cox t distribution, to model the intensity (depth of the non-zero streamflows. Time, seasonality and climate indices, describing the Pacific and Indian Ocean sea surface temperatures, are tested as covariates in the GAMLSS model to make probabilistic 6 and 12-month forecasts of the occurrence and intensity of streamflow. The output reveals that in the study region the occurrence and variability of flow is driven by sea surface temperatures and therefore forecasts can be made with some skill.

  6. Scaling, Intermittency and Decay of MHD Turbulence

    International Nuclear Information System (INIS)

    Lazarian, A.; Cho, Jungyeon

    2005-01-01

    We discuss a few recent developments that are important for understanding of MHD turbulence. First, MHD turbulence is not so messy as it is usually believed. In fact, the notion of strong non-linear coupling of compressible and incompressible motions along MHD cascade is not tenable. Alfven, slow and fast modes of MHD turbulence follow their own cascades and exhibit degrees of anisotropy consistent with theoretical expectations. Second, the fast decay of turbulence is not related to the compressibility of fluid. Rates of decay of compressible and incompressible motions are very similar. Third, viscosity by neutrals does not suppress MHD turbulence in a partially ionized gas. Instead, MHD turbulence develops magnetic cascade at scales below the scale at which neutrals damp ordinary hydrodynamic motions. Forth, density statistics does not exhibit the universality that the velocity and magnetic field do. For instance, at small Mach numbers the density is anisotropic, but it gets isotropic at high Mach numbers. Fifth, the intermittency of magnetic field and velocity are different. Both depend on whether the measurements are done in a local system of reference oriented along the local magnetic field or in the global system of reference related to the mean magnetic field

  7. The "galloping" history of intermittent claudication.

    Science.gov (United States)

    Bollinger, A; Eckert, J; Rüttimann, B; Becker, F

    2000-11-01

    Intermittent claudication (IC) due to arterial occlusive disease was first diagnosed by the French veterinary surgeon Jean-François Bouley jeune in a horse drawing a cabriolet in the streets of Paris as early as 1831. The animal was repeatedly exercised and always started to limp with the hind legs at similar work loads. Autopsy revealed partially thrombosed aneurysm of the abdominal aorta and occlusions of both femoral arteries which were correctly identified as the cause of IC. In 1858 the famous neurologist Jean-Martin Charcot working at the Salpêtrière in Paris first discovered the condition in a patient, who was wounded by a bullet during the conquest of Algery and developed iliac artery aneurysm obliterated by a thrombus. He was aware of the first description in veterinary medicine. In Germany IC was also first mentioned in horses (Rademacher, 1838). 13 reports of patients were contributed by the neurologist Heinrich Erb in 1898 and 1904. Some interesting features of the phenomenon of IC like the amount of exercise necessary to provoke it, localization, social relevance, prolongation of the Achilles tendon reflex, decrease of maximal plantar flexion force of the foot and production of "Lewis factor p" are summarized. In human patients arteriosclerosis is the well recognized principal cause of arterial obstructions, in horses, however, the lesions are due to infection by the roundworm Strongylus vulgaris. In the fascinating life cycle the larvae migrate into the intima of small and large arteries and provoke aneurysms and intravascular thrombosis.

  8. Emotion regulation deficits in intermittent explosive disorder.

    Science.gov (United States)

    Fettich, Karla C; McCloskey, Michael S; Look, Amy E; Coccaro, Emil F

    2015-01-01

    Intermittent explosive disorder (IED) is a psychiatric disorder characterized by repeated acts of affective aggression. Despite the diagnostic emphasis on the failure to control aggressive impulses, there is little research on affective processes and emotion regulation in IED; however, this research suggests possible dysfunctions in experiences of emotional intensity and lability. The hypothesis in the present study was that compared to individuals with other psychiatric disorders, and psychologically healthy individuals, individuals with IED experience greater negative affect intensity and emotional lability. Participants (N = 373) consisted of 202 individuals diagnosed with IED, 68 non-IED psychiatric controls (PC), and 103 healthy volunteers (HV). Emotion regulation was assessed using the General Behavior Inventory, the Affective Lability Scale, and the Affect Intensity Measure. Results showed that IED participants reported greater negative affect intensity and greater emotional lability across several emotion domains (e.g., anger, anxiety, depression) than PC and HV participants. These findings suggest that IED is characterized by more global emotion regulation deficits than those associated with anger alone. Aggr. Behav. 41:25-33 2015. © 2014 Wiley Periodicals, Inc. © 2014 Wiley Periodicals, Inc.

  9. Defense styles in Intermittent Explosive Disorder.

    Science.gov (United States)

    Puhalla, Alexander A; McCloskey, Michael S; Brickman, Lauren J; Fauber, Robert; Coccaro, Emil F

    2016-04-30

    The overreliance on immature and/or neurotic defense mechanisms, as opposed to more mature defensive functioning has been linked to several psychiatric disorders. However, to date, the role of defense styles among individuals with Intermittent Explosive Disorder (IED) has not been examined. Given that individuals with IED display difficulties controlling their anger and aggression, one might expect these individuals to exhibit more immature and less mature defense styles. The current study compared participants with IED to a personality disorder (PD) comparison group, as well as to healthy volunteers (HV) on the Defense Style Questionnaire, a self-report measure that assesses the extent to which individuals endorse using mature, immature, and neurotic defense styles. Subjects with IED had significantly higher scores than both comparison groups on immature defense styles and exhibited lower scores on mature defense mechanisms. Hierarchical regression of significant defense style subscales showed that higher levels of acting out and lower levels of sublimation uniquely discriminated participants with IED from the PD and HV comparison groups. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  10. Endotracheal suctioning of the adult intubated patient--what is the evidence?

    DEFF Research Database (Denmark)

    Pedersen, Carsten M; Rosendahl-Nielsen, Mette; Hjermind, Jeanette

    2008-01-01

    bleeding, infection, atelectasis, hypoxemia, cardiovascular instability, elevated intracranial pressure, and may also cause lesions in the tracheal mucosa. The aim of this article was to review the available literature regarding endotracheal suctioning of adult intubated intensive care patients......s, performing continuous rather than intermittent suctioning, avoiding saline lavage, providing hyperoxygenation before and after the suction procedure, providing hyperinflation combined with hyperoxygenation on a non-routine basis, always using aseptic technique, and using either closed or open...

  11. Factors Relevant to Utility Integration of Intermittent Renewable Technologies

    Energy Technology Data Exchange (ETDEWEB)

    Wan, Y.; Parsons, B.

    1993-08-24

    This study assesses factors that utilities must address when they integrate intermittent renewable technologies into their power-supply systems; it also reviews the literature in this area and has a bibliography containing more than 350 listings. Three topics are covered: (1) interface (hardware and design-related interconnection), (2) operability/stability, and (3) planning. This study finds that several commonly held perceptions regarding integration of intermittent renewable energy technologies are not valid. Among fmdings of the study are the following: (1) hardware and system design advances have eliminated most concerns about interface, (2) cost penalties have not occurred at low to moderate penetration levels (and high levels am feasible); and (3) intermittent renewable energy technologies can have capacity values. Obstacles still interfering with intermittent renewable technologies are also indentified.

  12. Factors relevant to utility integration of intermittent renewable technologies

    Energy Technology Data Exchange (ETDEWEB)

    Wan, Yih-huei; Parsons, B.K.

    1993-08-01

    This study assesses factors that utilities must address when they integrate intermittent renewable technologies into their power-supply systems; it also reviews the literature in this area and has a bibliography containing more than 350 listings. Three topics are covered: (1) interface (hardware and design-related interconnection), (2) operability/stability, and (3) planning. This study finds that several commonly held perceptions regarding integration of intermittent renewable energy technologies are not valid. Among findings of the study are the following: (1) hardware and system design advances have eliminated most concerns about interface; (2) cost penalties have not occurred at low to moderate penetration levels (and high levels are feasible); and (3) intermittent renewable energy technologies can have capacity values. Obstacles still interfering with intermittent renewable technologies are also identified.

  13. Scaling laws and intermittent structures in solar wind MHD turbulence

    Science.gov (United States)

    Veltri, Pierluigi; Mangeney, André

    1999-06-01

    Thirteen months of velocity and magnetic field data from ISEE space experiment have been used to calculate spectra and structure functions using Haar wavelets technique in the range from 1 minute to about 1 day. Using conditioned structure function definition we have been able to eliminate the intermittency effects in the spectra and thus to evidentiate which kind of phenomenology of nonlinear cascade between Kolmogorov and Kraichnan is taking place in Solar Wind turbulence. By the same technique the most intermittent structures in solar wind turbulence can also be identified and they turn out to be either shock waves or one dimensional current sheets, at variance with ordinary fluid intermittency, where the most intermittent structures are two dimensional vortices.

  14. Computing moving and intermittent queue propagation in highway work zones.

    Science.gov (United States)

    2012-07-01

    Drivers may experience intermittent congestion and moving queue conditions in work zones due to several reasons such as presence of lane closure, roadway geometric changes, higher demand, lower speed, and reduced capacity. The congestion and queue ha...

  15. Sensing and characterization of EMI during intermittent connector anomalies

    Data.gov (United States)

    National Aeronautics and Space Administration — This paper presents a new on-line methodology for detecting intermittent disconnection failures. The detection principle operates on the fundamental Lorentz Law that...

  16. Bound by Children: Intermittent Cohabitation and Living Together Apart

    OpenAIRE

    Cross-Barnet, Caitlin; Cherlin, Andrew; Burton, Linda

    2011-01-01

    In this article, we examine variations in low-income mothers' patterns of intermittent cohabitation and the voluntary and involuntary nature of these unions. Intermittent cohabitation involves couples living together and separating in repeating cycles. Using Three-City Study ethnographic data, we identified 45 low-income mothers involved in these arrangements, 18 of whom resided with their children's fathers occasionally while saying that they were not in a cohabiting relationship. We term su...

  17. Transfert thermique à travers une interface de contact intermittent en ...

    African Journals Online (AJOL)

    Transfert thermique à travers une interface de contact intermittent en régime périodique établi. ... Mots clés: modélisation; conduction; contact intermittent; pseudo résistance de contact; résistance de contact; couplage de matériaux. In this paper, we present one-dimensional model to describe the thermal transfer through an ...

  18. Scenedesmus dimorphus biofilm: Photoefficiency and biomass production under intermittent lighting

    OpenAIRE

    Andrea Efrem Toninelli; Junfeng Wang; Mingshen Liu; Hong Wu; Tianzhong Liu

    2016-01-01

    This study investigated the effect of intermittent lighting on the growth performances of a Scenedesmus dimorphus biofilm. Flashing light effect (FLE) is common in traditional suspended cultures of microalgae; yet, publications about this phenomenon, in the context of biofilm cultivation, are scarce. In this work we demonstrate that, thanks to intermittent illumination, it is possible for attached cultivations to fulfill FLE, improve photoefficiency and productivity as well as providing prote...

  19. The minimum transition hypothesis for intermittent hierarchical motor control

    Directory of Open Access Journals (Sweden)

    Amir eKarniel

    2013-02-01

    Full Text Available In intermittent control, instead of continuously calculating the control signal, the controller occasionally changes this signal at certain sparse points in time. The control law may include feedback, adaptation, optimization, or any other control strategies. When, where, and how does the brain employ intermittency as it controls movement? These are open questions in motor neuroscience. Evidence for intermittency in human motor control has been repeatedly observed in the neural control of movement literature. Moreover, some researchers have provided theoretical models to address intermittency. Even so, the vast majority of current models, and I would dare to say the dogma in most of the current motor neuroscience literature involves continuous control. In this paper, I focus on an area in which intermittent control has not yet been thoroughly considered, the structure of muscle synergies. A synergy in the muscle space is a group of muscles activated together by a single neural command. Under the assumption that the motor control is intermittent, I present the minimum transition hypothesis and its predictions with regards to the structure of muscle synergies. The minimum transitions hypothesis (MTH asserts that the purpose of synergies is to minimize the effort of the higher level in the hierarchy by minimizing the number of transitions in an intermittent control signal. The implications of the MTH are not only for the structure of the muscle synergies but also to the intermittent and hierarchical nature of the motor system, with various predictions as to the process of skill learning, and important implications to the design of brain machine interfaces and human robot interaction.

  20. The minimum transition hypothesis for intermittent hierarchical motor control.

    Science.gov (United States)

    Karniel, Amir

    2013-01-01

    In intermittent control, instead of continuously calculating the control signal, the controller occasionally changes this signal at certain sparse points in time. The control law may include feedback, adaptation, optimization, or any other control strategies. When, where, and how does the brain employ intermittency as it controls movement? These are open questions in motor neuroscience. Evidence for intermittency in human motor control has been repeatedly observed in the neural control of movement literature. Moreover, some researchers have provided theoretical models to address intermittency. Even so, the vast majority of current models, and I would dare to say the dogma in most of the current motor neuroscience literature involves continuous control. In this paper, I focus on an area in which intermittent control has not yet been thoroughly considered, the structure of muscle synergies. A synergy in the muscle space is a group of muscles activated together by a single neural command. Under the assumption that the motor control is intermittent, I present the minimum transition hypothesis (MTH) and its predictions with regards to the structure of muscle synergies. The MTH asserts that the purpose of synergies is to minimize the effort of the higher level in the hierarchy by minimizing the number of transitions in an intermittent control signal. The implications of the MTH are not only for the structure of the muscle synergies but also to the intermittent and hierarchical nature of the motor system, with various predictions as to the process of skill learning, and important implications to the design of brain machine interfaces and human robot interaction.

  1. Lactate Kinetics After Intermittent and Continuous Exercise Training

    OpenAIRE

    Gharbi, Adnene; Chamari, Karim; Kallel, Amjad; Ahmaidi, Saîd; Tabka, Zouhair; Abdelkarim, Zbidi

    2008-01-01

    The purpose of this study was to assess, the effects of continuous and intermittent exercise training on lactate kinetic parameters and maximal aerobic speed (MAS) using field tests. Twenty-four male sport students were equally divided into continuous (CT) and intermittent (IT) physically trained groups. Another six participants acted as non-trained controls (CG). The trained participants practiced 6-days per week for 6 weeks. Before and after training, all participants completed an increment...

  2. Suppression of methanogenesis in hydrogen fermentation by intermittent feeding.

    Science.gov (United States)

    Yun, Jeonghee; Kim, Tae Gwan; Cho, Kyung-Suk

    2015-01-01

    This study investigated whether intermittent feeding by using a concentrated carbon source is an appropriate method for selective enrichment of hydrogenesis by means of methanogen suppression. In a conventional reactor fed continuously for 10 d, methanogens increased from 2.8 × 10(7) to 1.1 × 10(9) gene copy number (GCN)/mg-cell dry weight, and methane concentration in the resulting biogas was 5.8%. However, when a carbon source was intermittently supplied for 10 d to the reactor, the number of methanogens was reduced 98.9% from 2.77 × 10(7) to 1.2 × 10(3) GCN/mg-cell dry weight, and methane was not detected during this period of intermittent feeding. Intermittent feeding shifted the dominants in the reactor from Clostridiaceae (70.5%) and Lactobacillaceae (11.0%) to Acetobacteraceae (62.0%) and Clostridiaceae (38.0%). In the reactor operated in continuous feeding mode after intermittent feeding, methane concentration was below 0.3% and the portion of methanogens in the bacterial community was maintained below 0.2%. These results suggest that the intermittent feeding of a carbon source during hydrogen production processes is a suitable method to suppress the activity of methanogens.

  3. Uncoupling of Vascular Nitric Oxide Synthase Caused by Intermittent Hypoxia

    Directory of Open Access Journals (Sweden)

    Mohammad Badran

    2016-01-01

    Full Text Available Objective. Obstructive sleep apnea (OSA, characterized by chronic intermittent hypoxia (CIH, is often present in diabetic (DB patients. Both conditions are associated with endothelial dysfunction and cardiovascular disease. We hypothesized that diabetic endothelial dysfunction is further compromised by CIH. Methods. Adult male diabetic (BKS.Cg-Dock7m +/+ Leprdb/J (db/db mice (10 weeks old and their heterozygote littermates were subjected to CIH or intermittent air (IA for 8 weeks. Mice were separated into 4 groups: IA (intermittent air nondiabetic, IH (intermittent hypoxia nondiabetic, IADB (intermittent air diabetic, and IHDB (intermittent hypoxia diabetic groups. Endothelium-dependent and endothelium-independent relaxation and modulation by basal nitric oxide (NO were analyzed using wire myograph. Plasma 8-isoprostane, interleukin-6 (IL-6, and asymmetric dimethylarginine (ADMA were measured using ELISA. Uncoupling of eNOS was measured using dihydroethidium (DHE staining. Results. Endothelium-dependent vasodilation and basal NO production were significantly impaired in the IH and IADB group compared to IA group but was more pronounced in IHDB group. Levels of 8-isoprostane, IL-6, ADMA, and eNOS uncoupling were ≈2-fold higher in IH and IADB groups and were further increased in the IHDB group. Conclusion. Endothelial dysfunction is more pronounced in diabetic mice subjected to CIH compared to diabetic or CIH mice alone. Oxidative stress, ADMA, and eNOS uncoupling were exacerbated by CIH in diabetic mice.

  4. The specificity of the Loughborough Intermittent Shuttle Test for recreational soccer players is independent of their intermittent running ability.

    Science.gov (United States)

    Coratella, Giuseppe; Beato, Marco; Schena, Federico

    2016-01-01

    The aim of the present study was to evaluate whether or not recreational soccer players (SP) and non-soccer players (non-SP) with similar intermittent-running ability had similar physiological responses to a soccer match-simulation protocol. Twenty-two recreational SP and 19 fitness-matched non-SP participated. Yo-Yo level 1 assessed intermittent-running ability, while the Loughborough Intermittent Shuttle Test served as soccer match-simulation protocol. Heart rate (HR), blood lactate concentration [La - ] and rating of perceived exertion (RPE) were recorded after each bout (1-5, plus an exhaustive task). SP had lower HR after the third, fourth and fifth bout, compared to non-SP. Similarly, SP had lower [La - ] after the third, fourth and the fifth bout. SP also had lower RPE after the third, fourth and fifth bout. The appropriateness of intermittent-running ability as the main determinant of physical performance in SP was questioned.

  5. Intermittency and Topology of Shock Induced Mixing

    Science.gov (United States)

    Tellez, Jackson; Redondo, Jose M.; Ben Mahjoub, Otman; Malik, Nadeem; Vila, Teresa

    2016-04-01

    The advance of a Rayleigh-Taylor front is described in Linden & Redondo (1991),[1-3] and may be shown to follow a quadratic law in time where the width of the growing region of instability depends on the local mixing efficiency of the different density fluids that accelerate against each other g is the acceleration and A is the Atwood number defined as the diference of densities divided by their sum. This results show the independence of the large amplitude structures on the initial conditions the width of the mixing region depends also on the intermittency of the turbulence. Then dimensional analysis may also depend on the relevant reduced acceleration driven time and the molecular reactive time akin to Damkholer number and the fractal structure of the contact zone [2,4]. Detailed experiments and simulations on RT and RM shock induced fronts analized with respect to structure functions are able to determine which mechanisms are most effective in local mixing which increase the effective fractal dimension, as well as the effect of higher order geometrical parameters, such as the structure functions, in non-homogeneous fluids (Mahjoub et al 1998)[5]. The structure of a Mixing blob shows a relatively sharp head with most of the mixing taking place at the sides due to what seems to be shear instability very similar to the Kelvin-Helmholtz instabilities, but with sideways accelerations. The formation of the blobs and spikes with their secondary instabilities produces a turbulent cascade, evident just after about 1 non-dimensional time unit, from a virtual time origin that takes into account the linear growth phase, as can be seen by the growth of the fractal dimension for different volume fractions. Two-dimensional cuts of the 3D flow also show that vortex flows have closed or spiral streamlines around their core. Examples of such flows can be also seen in the laboratory, for example at the interface of atwo-layer stratified fluid in a tank in which case streamlines

  6. Intermittent Turbulence in the Very Stable Ekman Layer

    Energy Technology Data Exchange (ETDEWEB)

    Barnard, James C [Univ. of Washington, Seattle, WA (United States)

    2001-01-01

    This study describes a Direct Numerical Simulation (DNS) of a very stable Ekman layer in which a constant downward heat flux is applied at the lower boundary, thus cooling the fluid above. Numerical experiments were performed in which the strength of the imposed heat flux was varied. For downward heat fluxes above a certain critical value the turbulence becomes intermittent and, as the heat flux increases beyond this value, the flow tends to relaminarize because of the very strong ambient stratification. We adopt Mahrt?s (1999) definition of the very stable boundary layer as a boundary layer in which intermittent, rather than continuous turbulence, is observed. Numerical experiments were used to test various hypothesis of where in ?stability parameter space? the very stable boundary layer is found. These experiments support the findings of Howell and Sun (1999) that the boundary layer will exhibit intermittency and therefore be categorized as ?very stable?, when the stability parameter, z/L, exceeds unity. Another marker for the very stable boundary layer, Derbyshire?s (1990) maximum heat flux criterion, was also examined. Using a case study drawn from the simulations where turbulence intermittency was observed, the mechanism that causes the intermittence was investigated. It was found that patchy turbulence originates from a vigorous inflectional, Ekman-like instability -- a roll cell -- that lifts colder air over warmer air. The resulting convective instability causes an intense burst of turbulence. This turbulence is short-lived because the lifting motion of the roll cell, as well as the roll cell itself, is partially destroyed after the patchy turbulence is generated. Examples of intermittent turbulence obtained from the simulations appear to be consistent with observations of intermittency even though the Reynolds number of the DNS is relatively low (400).

  7. Pressure Autoregulation Measurement Techniques in Adult Traumatic Brain Injury, Part I: A Scoping Review of Intermittent/Semi-Intermittent Methods.

    Science.gov (United States)

    Zeiler, Frederick A; Donnelly, Joseph; Calviello, Leanne; Menon, David K; Smielewski, Peter; Czosnyka, Marek

    2017-12-01

    The purpose of this study was to perform a systematic, scoping review of commonly described intermittent/semi-intermittent autoregulation measurement techniques in adult traumatic brain injury (TBI). Nine separate systematic reviews were conducted for each intermittent technique: computed tomographic perfusion (CTP)/Xenon-CT (Xe-CT), positron emission tomography (PET), magnetic resonance imaging (MRI), arteriovenous difference in oxygen (AVDO 2 ) technique, thigh cuff deflation technique (TCDT), transient hyperemic response test (THRT), orthostatic hypotension test (OHT), mean flow index (Mx), and transfer function autoregulation index (TF-ARI). MEDLINE ® , BIOSIS, EMBASE, Global Health, Scopus, Cochrane Library (inception to December 2016), and reference lists of relevant articles were searched. A two tier filter of references was conducted. The total number of articles utilizing each of the nine searched techniques for intermittent/semi-intermittent autoregulation techniques in adult TBI were: CTP/Xe-CT (10), PET (6), MRI (0), AVDO 2 (10), ARI-based TCDT (9), THRT (6), OHT (3), Mx (17), and TF-ARI (6). The premise behind all of the intermittent techniques is manipulation of systemic blood pressure/blood volume via either chemical (such as vasopressors) or mechanical (such as thigh cuffs or carotid compression) means. Exceptionally, Mx and TF-ARI are based on spontaneous fluctuations of cerebral perfusion pressure (CPP) or mean arterial pressure (MAP). The method for assessing the cerebral circulation during these manipulations varies, with both imaging-based techniques and TCD utilized. Despite the limited literature for intermittent/semi-intermittent techniques in adult TBI (minus Mx), it is important to acknowledge the availability of such tests. They have provided fundamental insight into human autoregulatory capacity, leading to the development of continuous and more commonly applied techniques in the intensive care unit (ICU). Numerous methods of

  8. Entropic-Skins Geometry to Describe Wall Turbulence Intermittency

    Directory of Open Access Journals (Sweden)

    Diogo Queiros-Conde

    2015-04-01

    Full Text Available In order to describe the phenomenon of intermittency in wall turbulence and, more particularly, the behaviour of moments  and and intermittency exponents ζP with the order p and distance to the wall, we developed a new geometrical framework called “entropic-skins geometry” based on the notion of scale-entropy which is here applied to an experimental database of boundary layer flows. Each moment has its own spatial multi-scale support Ωp (“skin”. The model assumes the existence of a hierarchy of multi-scale sets Ωp ranged from the “bulk” to the “crest”. The crest noted characterizes the geometrical support where the most intermittent (the highest fluctuations in energy dissipation occur; the bulk is the geometrical support for the whole range of fluctuations. The model assumes then the existence of a dynamical flux through the hierarchy of skins. The specific case where skins display a fractal structure is investigated. Bulk fractal dimension  and crest dimension  are linked by a scale-entropy flux defining a reversibility efficiency  (d is the embedding dimension. The model, initially developed for homogeneous and isotropic turbulent flows, is applied here to wall bounded turbulence where intermittency exponents are measured by extended self-similarity. We obtained for intermittency exponents the analytical expression with γ ≈ 0.36 in agreement with experimental results.

  9. Intermittent synchronization in a network of bursting neurons

    Science.gov (United States)

    Park, Choongseok; Rubchinsky, Leonid L.

    2011-09-01

    Synchronized oscillations in networks of inhibitory and excitatory coupled bursting neurons are common in a variety of neural systems from central pattern generators to human brain circuits. One example of the latter is the subcortical network of the basal ganglia, formed by excitatory and inhibitory bursters of the subthalamic nucleus and globus pallidus, involved in motor control and affected in Parkinson's disease. Recent experiments have demonstrated the intermittent nature of the phase-locking of neural activity in this network. Here, we explore one potential mechanism to explain the intermittent phase-locking in a network. We simplify the network to obtain a model of two inhibitory coupled elements and explore its dynamics. We used geometric analysis and singular perturbation methods for dynamical systems to reduce the full model to a simpler set of equations. Mathematical analysis was completed using three slow variables with two different time scales. Intermittently, synchronous oscillations are generated by overlapped spiking which crucially depends on the geometry of the slow phase plane and the interplay between slow variables as well as the strength of synapses. Two slow variables are responsible for the generation of activity patterns with overlapped spiking, and the other slower variable enhances the robustness of an irregular and intermittent activity pattern. While the analyzed network and the explored mechanism of intermittent synchrony appear to be quite generic, the results of this analysis can be used to trace particular values of biophysical parameters (synaptic strength and parameters of calcium dynamics), which are known to be impacted in Parkinson's disease.

  10. Intermittency on simultaneous observations of riometer at several Antarctic locations

    Science.gov (United States)

    Ovalle, E. M.; Foppiano, A. J.; Stepanova, M. V.; Weatherwax, A. T.

    2016-03-01

    It is well known that auroral radio wave absorption, as measured by riometers, consists of periods of relative quiescence which are interrupted by short bursts of activity. Such patterns in activity are observed in systems ranging from the stock market to turbulence, i.e. they exhibit intermittency. In the case of the auroral absorption it has also been found that intermittency strongly depends on the magnetic local time, being largest in the night-time sector. This can be interpreted as indicating that the precipitating particles responsible of the absorption exhibit intermittency, especially near the substorm eye, where the level of turbulence increases. Here, we analyse simultaneous observations of riometer absorption at seven Antarctic locations, to determine whether they exhibit intermittency. We determine the Probability Distribution Functions of the fluctuations of riometer absorption for absorption events larger than 0.1 dB, as well as those for the time-intervals between absorption events. Observations are for locations within the austral auroral absorption zone and on the polar cap. It is found that the parameters of a power law used to describe the calculated PDFs are consistent with the formation of coherent structures being more frequent within the auroral zone, as a manifestation of intermittency.

  11. Eccentric strength and endurance in patients with unilateral intermittent claudication

    Directory of Open Access Journals (Sweden)

    Márcio Basyches

    2009-04-01

    Full Text Available OBJECTIVE: To analyze concentric and eccentric strength and endurance in patients with unilateral intermittent claudication. INTRODUCTION: Basic motor tasks are composed of concentric, isometric, and eccentric actions, which are related and contribute to physical performance. In previous studies of patients with intermittent claudication, the disease-related reduction in concentric and isometric muscular strength and endurance resulted in poorer walking performance. To date, no study has evaluated eccentric muscle action in patients with intermittent claudication. METHODS: Eleven patients with unilateral intermittent claudication performed isokinetic concentric and eccentric actions at the ankle joints to assess peak torque and total work in both symptomatic and asymptomatic legs. RESULTS: Concentric peak torque and total work were lower in the symptomatic than in the asymptomatic leg (80 ± 32 vs. 95 ± 41 N/m, P = 0.01; 1479 ± 667 vs. 1709 ± 879 J, P = 0.03, respectively. There were no differences in eccentric peak torque and total work between symptomatic and asymptomatic legs (96 ± 30 vs. 108 ± 48 N/m; 1852 ± 879 vs. 1891 ± 755 J, respectively. CONCLUSION: Strength and endurance in the symptomatic leg were lower during concentric compared to eccentric action. Future studies are recommended to investigate the mechanisms underlying these responses and to analyze the effects of interventions to improve concentric strength and endurance on functional limitations in patients with intermittent claudication.

  12. Complex economic dynamics: Chaotic saddle, crisis and intermittency

    International Nuclear Information System (INIS)

    Chian, Abraham C.-L.; Rempel, Erico L.; Rogers, Colin

    2006-01-01

    Complex economic dynamics is studied by a forced oscillator model of business cycles. The technique of numerical modeling is applied to characterize the fundamental properties of complex economic systems which exhibit multiscale and multistability behaviors, as well as coexistence of order and chaos. In particular, we focus on the dynamics and structure of unstable periodic orbits and chaotic saddles within a periodic window of the bifurcation diagram, at the onset of a saddle-node bifurcation and of an attractor merging crisis, and in the chaotic regions associated with type-I intermittency and crisis-induced intermittency, in non-linear economic cycles. Inside a periodic window, chaotic saddles are responsible for the transient motion preceding convergence to a periodic or a chaotic attractor. The links between chaotic saddles, crisis and intermittency in complex economic dynamics are discussed. We show that a chaotic attractor is composed of chaotic saddles and unstable periodic orbits located in the gap regions of chaotic saddles. Non-linear modeling of economic chaotic saddle, crisis and intermittency can improve our understanding of the dynamics of financial intermittency observed in stock market and foreign exchange market. Characterization of the complex dynamics of economic systems is a powerful tool for pattern recognition and forecasting of business and financial cycles, as well as for optimization of management strategy and decision technology

  13. Intermittent hypoxia induces functional recovery following cervical spinal injury.

    Science.gov (United States)

    Vinit, Stéphane; Lovett-Barr, Mary Rachael; Mitchell, Gordon S

    2009-11-30

    Respiratory-related complications are the leading cause of death in spinal cord injury (SCI) patients. Few effective SCI treatments are available after therapeutic interventions are performed in the period shortly after injury (e.g. spine stabilization and prevention of further spinal damage). In this review we explore the capacity to harness endogenous spinal plasticity induced by intermittent hypoxia to optimize function of surviving (spared) neural pathways associated with breathing. Two primary questions are addressed: (1) does intermittent hypoxia induce plasticity in spinal synaptic pathways to respiratory motor neurons following experimental SCI? and (2) can this plasticity improve respiratory function? In normal rats, intermittent hypoxia induces serotonin-dependent plasticity in spinal pathways to respiratory motor neurons. Early experiments suggest that intermittent hypoxia also enhances respiratory motor output in experimental models of cervical SCI (cervical hemisection) and that the capacity to induce functional recovery is greater with longer durations post-injury. Available evidence suggests that intermittent hypoxia-induced spinal plasticity has considerable therapeutic potential to treat respiratory insufficiency following chronic cervical spinal injury.

  14. ANESTHETIC MANAGEMENT FOR A PATIENT WITH ACUTE INTERMITTENT PORPHYRIA

    Directory of Open Access Journals (Sweden)

    Nenad Savić

    2010-09-01

    Full Text Available Acute intermittent porphyria is a rare metabolic disorder resulting from a partial deficiency of porphobilinogen deaminase, enzyme in the heme biosynthetic pathway. Its inheritance is autosomal dominant. A deficiency of porphobilinogen deaminase is not sufficient by its self to produce acute intermittent porphyria, and other activating factors must also be present. These include some drugs, hormones, infection, injury and alcohol. Besides others, anesthetics have been implicated in the triggering of a number of severe porphyric reactions. Although there is no clinical evidence, the fear of hypothesized porphyrinogenicity of repetitive anesthetics exposures still remains. Despite these doubts, we report here the case of uneventful repeated exposure to anesthetics in a patient suffering from acute intermittent porphyria, within a fifteen- month period. On both occasions, the patient was safely exposed to certain anesthetics included: propofol, sevoflurane, rocuronium, midazolam and fentanyl.

  15. Bound by Children: Intermittent Cohabitation and Living Together Apart.

    Science.gov (United States)

    Cross-Barnet, Caitlin; Cherlin, Andrew; Burton, Linda

    2011-12-01

    In this article, we examine variations in low-income mothers' patterns of intermittent cohabitation and the voluntary and involuntary nature of these unions. Intermittent cohabitation involves couples living together and separating in repeating cycles. Using Three-City Study ethnographic data, we identified 45 low-income mothers involved in these arrangements, 18 of whom resided with their children's fathers occasionally while saying that they were not in a cohabiting relationship. We term such relationships living together apart (LTA). Data analysis revealed that distinct patterns of voluntary and involuntary separations and reunifications characterized intermittent cohabitation and LTA and that these relationships were shaped by the bonds that shared parenting created and the economic needs of both parents. We argue that these dimensions may explain some disparate accounts of cohabitation status in low-income populations. They also demonstrate previously unexplored diversity in cohabiting relationships and suggest further questioning contemporary definitions of families.

  16. Intermittency in e+e- and lepton-hadron collisions

    International Nuclear Information System (INIS)

    Sugano, K.

    1990-01-01

    The intermittency data in e + e - and lepton-hadron collisions are reviewed. The power-law behavior of the moments has been established by various e + e - experiments and a μp experiment. The intermittency in the two-dimensional space of rapidity and azimuthal angle is much stronger than in the rapidity space only. The neutrino-nucleus data indicate significant effects from nuclear reinteractions. The LUND parton shower model fits the data better than the matrix element model without special retuning. The relations among the moments of different orders are in good agreement with the predictions by the negative binomial and pure birth distributions. The origin of the intermittency in e + e - and μp collisions is consistent with the self-similar cascade mechanism of jet formation. 11 refs., 7 figs

  17. Multiparticle correlations and intermittency in high energy collisions

    International Nuclear Information System (INIS)

    Bozek, P.

    1992-01-01

    The analysis of the intermittency signal observed in high energy experiments is presented using multiparticle distributions and correlation functions. The effect of the dimensional projection of the multiparticle distributions on one or two-dimensional subspace is discussed. The structure of the multiparticle cumulants is analyzed for the DELPHI e + e - annihilation data. The model of spatiotemporal intermittency is discussed in details and is shown to reproduce qualitatively the dependence of the intermittency strength on the target and projectile nuclei. A 1-dimensional (1D) cellular-automaton and a 1D forest-fire model is studied. On the example of the noncritical 1D Ising model the difficulties of the scaled factorial moment (SFM) method in extracting genuine scaling behaviour is illustrated. All these studies could serve as tools to test the sensibility of the SFM method as used in the analysis of the high energy production. (K.A.) 122 refs.; 38 figs.; 3 tabs

  18. Effect of Linguizhugan decoction on hyperlipidemia rats with intermittent fasting.

    Science.gov (United States)

    Yang, Yubin; Qin, Jian; Ke, Bin; Zhang, Junjie; Shi, Lanying; Li, Qiong

    2013-04-01

    To explore the effect of Linguizhugan decoction on hyperlipidemia rats with caloric restriction. The hyperlipidemia model of rat was induced by high fat diet for 8 weeks. After the model was established, 26 rats were randomly divided into 4 groups: the control group (n = 6), the model group (n = 6), the intermittent fasting (IF) group (n = 8), and the IF and herbal medicine (IFH) group (n = 6). IF group was applied intermittent fasting every other day. The IFH group was given Linguizhugan decoction every day and intermittent fasting every other day. Blood samples were taken at the end of 16 weeks, and serum ghrelin and lipid was tested. Serum ghrelin in the IF group significantly increased (P < 0.01). Serum ghrelin in IFH group was lower than the IF group (P < 0.05), but higher than the model group (P < 0.01). Linguizhugan decoction may play a part in regulation of energy and appetite in hyperlipidemia rats with IF.

  19. Controls on streamflow intermittence in the Colorado Front Range

    Science.gov (United States)

    Kampf, S. K.; Puntenney, K.; Martin, C.; Weber, R.; Gerlich, J.; Hammond, J. C.; Lefsky, M. A.

    2017-12-01

    Intermittent streams comprise more than 60% of the channel length in semiarid northern Colorado, yet little is known about their flow magnitude and timing. We used field surveys, stream sensors, and remote sensing to quantify spatial and temporal patterns of streamflow intermittence in the Cache la Poudre basin in 2016-2017. To evaluate potential controls on streamflow intermittence, we delineated the drainage area to each monitored point and quantified the catchment's mean precipitation, temperature, snow persistence, slope, aspect, vegetation type, soil type, and bedrock geology. During the period of study, most streams below 2500 m elevation and 1 km2 had perennial flow, whereas nearly all streams with drainage areas GIS data products. Initial analyses have identified no clearly quantifiable controls on flow duration of high elevation streams, but field observations indicate subsurface flow paths are important contributors to surface streams.

  20. Analyzing the Efficiency of Introduction of the Intermittent Heating Mode

    Science.gov (United States)

    Anisimova, E.; Shcherbak, A.

    2017-11-01

    The efficiency of introduction of an optimal intermittent heating mode for a service center building in Chelyabinsk is estimated. The optimal intermittent heating mode ensures heat energy saving while maintaining the required microclimate parameters. The graphical dependencies of the amount of heat energy saving on the heat retention of the building and the outdoor air temperature are shown. The fundamental formulas which were the basis for calculating the periods of cooling, warming and expenditures of heat energy for the two heating modes are given. The literature on the issue is reviewed, the main points, advantages and disadvantages in the works of both Russian and foreign authors are revealed. The calculation was carried out in compliance with the modern state standards and regulatory documents. The capital costs of a system construction with an intermittent heating mode are determined.

  1. Acute intermittent porphyria with SIADH and fluctuating dysautonomia.

    Science.gov (United States)

    Nabin, A; Thapa, L J; Paudel, R; Rana, P V S

    2012-01-01

    Three cases of acute intermittent porphyria are reported. While in first case severe pain in abdomen with intermittent exacerbation was the only presentation, the second patient presented as accelerated hypertension and acute abdominal crises in whom the clinical course was characterized by development of deep coma due to inappropriate secretion of antidiuretic hormone before she made complete recovery. The third patient, initially manifested as acute encephalitic syndrome. After initial improvement, she developed features of acute intermittent porphyria i.e. acute abdomen, neuropsychiatric symptoms, and rapidly progressing acute motor neuropathy leading to respiratory and bulbar paralysis. In addition, she developed severe and fluctuating dysautonomia leading to cardiac arrest and fatal termination. The importance of early diagnosis, recognition of autonomic disturbances, prompt treatment and counseling for avoidance of precipitating factors is stressed.

  2. Generation of intermittent gravitocapillary waves via parametric forcing

    Science.gov (United States)

    Castillo, Gustavo; Falcón, Claudio

    2018-04-01

    We report on the generation of an intermittent wave field driven by a horizontally moving wave maker interacting with Faraday waves. The spectrum of the local gravitocapillary surface wave fluctuations displays a power law in frequency for a wide range of forcing parameters. We compute the probability density function of the local surface height increments, which show that they change strongly across time scales. The structure functions of these increments are shown to display power laws as a function of the time lag, with exponents that are nonlinear functions of the order of the structure function. We argue that the origin of this scale-invariant intermittent spectrum is the Faraday wave pattern breakup due to its advection by the propagating gravity waves. Finally, some interpretations are proposed to explain the appearance of this intermittent spectrum.

  3. Multiparticle correlations and intermittency in high energy collisions

    CERN Document Server

    Bozek, P

    1992-01-01

    In this work the analysis of the intermittency signal observed in high energy experi- ments is done using multiparticle distributions and correlation functions. The effect of the dimensional projection of the multiparticle distributions on one or two-dimensional subspace is discussed. The structure of the multiparticle cumulants is analyzed for the DELPHI e + e~ annihilation data. The language of the self-similar distribution func- tions, which is used in this work, is shown to be largely equivalent to the well known a-model. In the case of the ultrarelativistic nuclear collisions, where the Monte-Carlo simulations fail to reproduce the data, we argue that the observed intermittency pattern is a signal of some nonlinear effect beyond the simple superposition of nucleon-nucleon collisions. The model of spatiotemporal intermittency is discussed in details and is shown to reproduce qualitatively the dependence of t...

  4. The intermittency of vector fields and random-number generators

    Science.gov (United States)

    Kalinin, A. O.; Sokoloff, D. D.; Tutubalin, V. N.

    2017-09-01

    We examine how well natural random-number generators can reproduce the intermittency phenomena that arise in the transfer of vector fields in random media. A generator based on the analysis of financial indices is suggested as the most promising random-number generator. Is it shown that even this generator, however, fails to reproduce the phenomenon long enough to confidently detect intermittency, while the C++ generator successfully solves this problem. We discuss the prospects of using shell models of turbulence as the desired generator.

  5. Quasi-one-dimensional intermittent flux behavior in superconducting films

    DEFF Research Database (Denmark)

    Qviller, A. J.; Yurchenko, V. V.; Galperin, Y. M.

    2012-01-01

    Intermittent filamentary dynamics of the vortex matter in superconductors is found in films of YBa2Cu3O7-δ deposited on tilted substrates. Deposition of this material on such substrates creates parallel channels of easy flux penetration when a magnetic field is applied perpendicular to the film....... The intermittent behavior shows no threshold value in the applied field, in contrast to conventional flux jumping. The results strongly suggest that the quasi-one-dimensional flux jumps are of a different nature than the thermomagnetic dendritic (branching) avalanches that are commonly found in superconducting...

  6. Multi-scale magnetic field intermittence in the plasma sheet

    Directory of Open Access Journals (Sweden)

    Z. Vörös

    2003-09-01

    Full Text Available This paper demonstrates that intermittent magnetic field fluctuations in the plasma sheet exhibit transitory, localized, and multi-scale features. We propose a multifractal-based algorithm, which quantifies intermittence on the basis of the statistical distribution of the "strength of burstiness", estimated within a sliding window. Interesting multi-scale phenomena observed by the Cluster spacecraft include large-scale motion of the current sheet and bursty bulk flow associated turbulence, interpreted as a cross-scale coupling (CSC process.Key words. Magnetospheric physics (magnetotail; plasma sheet – Space plasma physics (turbulence

  7. Effects of Intermittent Fasting, Caloric Restriction, and Ramadan Intermittent Fasting on Cognitive Performance at Rest and During Exercise in Adults.

    Science.gov (United States)

    Cherif, Anissa; Roelands, Bart; Meeusen, Romain; Chamari, Karim

    2016-01-01

    The aim of this review was to highlight the potent effects of intermittent fasting on the cognitive performance of athletes at rest and during exercise. Exercise interacts with dietary factors and has a positive effect on brain functioning. Furthermore, physical activity and exercise can favorably influence brain plasticity. Mounting evidence indicates that exercise, in combination with diet, affects the management of energy metabolism and synaptic plasticity by affecting molecular mechanisms through brain-derived neurotrophic factor, an essential neurotrophin that acts at the interface of metabolism and plasticity. The literature has also shown that certain aspects of physical performance and mental health, such as coping and decision-making strategies, can be negatively affected by daylight fasting. However, there are several types of intermittent fasting. These include caloric restriction, which is distinct from fasting and allows subjects to drink water ad libitum while consuming a very low-calorie food intake. Another type is Ramadan intermittent fasting, which is a religious practice of Islam, where healthy adult Muslims do not eat or drink during daylight hours for 1 month. Other religious practices in Islam (Sunna) also encourage Muslims to practice intermittent fasting outside the month of Ramadan. Several cross-sectional and longitudinal studies have shown that intermittent fasting has crucial effects on physical and intellectual performance by affecting various aspects of bodily physiology and biochemistry that could be important for athletic success. Moreover, recent findings revealed that immunological variables are also involved in cognitive functioning and that intermittent fasting might impact the relationship between cytokine expression in the brain and cognitive deficits, including memory deficits.

  8. Intermittent screening and treatment versus intermittent preventive treatment of malaria in pregnancy: provider knowledge and acceptability.

    Directory of Open Access Journals (Sweden)

    Lucy Smith Paintain

    Full Text Available Malaria in pregnancy (MiP is associated with increased risks of maternal and foetal complications. The WHO recommends a package of interventions including intermittent preventive treatment (IPT with sulphadoxine-pyrimethamine (SP, insecticide-treated nets and effective case management. However, with increasing SP resistance, the effectiveness of SP-IPT has been questioned. Intermittent screening and treatment (IST has recently been shown in Ghana to be as efficacious as SP-IPT. This study investigates two important requirements for effective delivery of IST and SP-IPT: antenatal care (ANC provider knowledge, and acceptance of the different strategies. Structured interviews with 134 ANC providers at 67 public health facilities in Ashanti Region, Ghana collected information on knowledge of the risks and preventative and curative interventions against MiP. Composite indicators of knowledge of SP-IPT, and case management of MiP were developed. Log binomial regression of predictors of provider knowledge was explored. Qualitative data were collected through in-depth interviews with fourteen ANC providers with some knowledge of IST to gain an indication of the factors influencing acceptance of the IST approach. 88.1% of providers knew all elements of the SP-IPT policy, compared to 20.1% and 41.8% who knew the treatment policy for malaria in the first or second/third trimesters, respectively. Workshop attendance was a univariate predictor of each knowledge indicator. Qualitative findings suggest preference for prevention over cure, and increased workload may be barriers to IST implementation. However, a change in strategy in the face of SP resistance is likely to be supported; health of pregnant women is a strong motivation for ANC provider practice. If IST was to be introduced as part of routine ANC activities, attention would need to be given to improving the knowledge and practices of ANC staff in relation to appropriate treatment of MiP. Health

  9. Pollution by air filters: Continuous vs intermittent air flow

    NARCIS (Netherlands)

    Cox, C.W.J.; Bluyssen, P.M.

    2000-01-01

    Within the framework of the EU research project Airless, a long-term experiment of 28 weeks was carried out to investigate the influence of intermittent airflow compared to continuous airflow on the pollution effect of glass fibre filters (F7). No statistical relevant differences between odour

  10. Benign intermittent gastric outlet obstruction in an elderly ...

    African Journals Online (AJOL)

    duration without any alarming symptoms. On upper GI endoscopy she was found to have gastric polyp with a long stalk which was partially obstructing her pyloric ring giving rise to features of intermittent gastric outlet obstruction Polypectomy was done with complete relief of symptoms .She is following our clinic for last 6 ...

  11. missed opportunities for intermittent preventive treatment for malaria ...

    African Journals Online (AJOL)

    Background: Malaria is of global health concern particularly among pregnant women. Nigeria contributes largely to global burden but coverage of. Intermittent Preventive Treatment of malaria in pregnancy using. Sulphadoxine pyrimethamine ..... awareness campaigns at sensitizing the community about the dangers of ...

  12. Governance, legislation and protection of intermittent rivers and ephemeral streams

    Science.gov (United States)

    Institutions and processes governing the conveyance and control of water have a long history. In this chapter, we discuss the extent to which water governance systems consider the management of intermittent rivers and ephemeral streams (IRES) and identify where research could inf...

  13. Muscle Fatigue during Intermittent Exercise in Individuals with Mental Retardation

    Science.gov (United States)

    Zafeiridis, Andreas; Giagazoglou, Paraskevi; Dipla, Konstantina; Salonikidis, Konstantinos; Karra, Chrisanthi; Kellis, Eleftherios

    2010-01-01

    This study examined fatigue profile during intermittent exercise in 10 men with mild to moderate mental retardation (MR) and 10 men without mental retardation (C). They performed 4 x 30 s maximal knee extensions and flexions with 1-min rest on an isokinetic dynamometer. Peak torque of flexors (PTFL) and extensors (PTEX), total work (TW), and…

  14. Intermittent Preventive Therapy and Treatment of Malaria during ...

    African Journals Online (AJOL)

    Intermittent Preventive Therapy and Treatment of Malaria during Pregnancy: A Study of Knowledge among Pregnant Women in Rufiji District, Southern Tanzania. ... Most women (76.6 %) did not know the use of SP for IPT in relationship with gestation age. Overall, the results show that most women had very low knowledge ...

  15. Biomonitoring of intermittent rivers and ephemeral streams in Europe

    NARCIS (Netherlands)

    Stubbington, Rachel; Chadd, Richard; Cid, Núria; Csabai, Zoltán; Miliša, Marko; Morais, Manuela; Munné, Antoni; Pařil, Petr; Pešić, Vladimir; Tziortzis, Iakovos; Verdonschot, Ralf C.M.; Datry, Thibault

    2018-01-01

    Intermittent rivers and ephemeral streams (IRES) are common across Europe and dominate some Mediterranean river networks. In all climate zones, IRES support high biodiversity and provide ecosystem services. As dynamic ecosystems that transition between flowing, pool, and dry states, IRES are

  16. Factors influencing utilization of intermittent presumptive treatment of ...

    African Journals Online (AJOL)

    Background: Intermittent presumptive treatment of malaria in pregnancy (IPTp) is one of the recommended interventions by World Health Organization to mitigate the impact of malaria in pregnancy in malaria stable transmission zones such as Sub Saharan regions so as to ensure the best outcome for both the mother and ...

  17. Acute intermittent porphyria: Diagnostic dilemma and treatment options

    Directory of Open Access Journals (Sweden)

    Mohan Deep Kaur

    2015-01-01

    Full Text Available Acute intermittent porphyria (AIP presents with diverse group of symptoms making its early diagnosis difficult. Delaying diagnosis and treatment of AIP can be fatal or can cause long term or permanent neurological damage. We present here a case report of AIP where the diagnosis was missed. The diversity of symptoms and details concerning the treatment options for AIP are discussed.

  18. From quantum fields to fractal structures: intermittency in particle physics

    International Nuclear Information System (INIS)

    Peschanski, R.

    1991-01-01

    Some features and theoretical interpretations of the intermittency phenomenon observed in high-energy multi-particle production are recalled. One develops on the various connections found with fractal structuration of fluctuations in turbulence, spin-glass physics and aggregation phenomena described by the non-linear Smoluchowski equation. This may lead to a new approach to quantum field properties

  19. Two-scale analysis of intermittency in fully developed turbulence

    Energy Technology Data Exchange (ETDEWEB)

    Badii, R.; Talkner, P. [Paul Scherrer Inst. (PSI), Villigen (Switzerland)

    1999-08-01

    A self-affinity test for turbulent time series is applied to experimental data for the estimation of intermittency exponents. The method employs exact relations satisfied by joint expectations of observables computed across two different length scales. One of these constitutes a verification tool for the existence and the extent of the inertial range. (author) 2 figs., 13 refs.

  20. Giant urethral stone in a patient using clean intermittant catheterization

    Directory of Open Access Journals (Sweden)

    Abdullah Gedik

    2011-06-01

    Full Text Available Urethral stone is a rare entity in clinical practice. Primary urethral stone happening directly in urethra is even rare, and it usually occurs as a result frequent urinary infection, urethral stricture and trauma.While the application of clear intermittant catheterization reliably protects bladder function, in long term use, it may cause various complications.In this case, we discussed giant urethral stone in a patient who has been acting clean intermittent catheterization regularly and without problem fort he last five years and who has had total loss of sensation in this lower extremity as a result of falling from height. Considering that the urethral calibration, in the patient acting clean intermittent catheterization is interesting, the giant urethra stone as much as examined such a case has not been presented in literature.In the patient acting clean intermittent catheterization and having loss of urethral sensation and with neurogenic bladder, we call attention to urethral pathologies the symptoms of which were seeing late

  1. Clean Intermittent Catheterization: Overview of Results in 194 ...

    African Journals Online (AJOL)

    Background: Clean intermittent catheterization (CIC) is a life-saving procedure in children with spina bifida, but its effectiveness in Kenya has not been previously documented. Patients and Methods: The current study analyzed the application of CIC in a series of 194 patients with spina bifida who fulfilled set criteria for ...

  2. Intermittent stimulus presentation stabilizes neuronal responses in macaque area MT

    NARCIS (Netherlands)

    Klink, P.C.; Oleksiak, A.; Lankheet, M.J.M.; Wezel, R.J.A.

    2012-01-01

    Klink PC, Oleksiak A, Lankheet MJ, van Wezel RJ. Intermittent stimulus presentation stabilizes neuronal responses in macaque area MT. J Neurophysiol 108: 2101-2114, 2012. First published July 25, 2012; doi: 10.1152/jn.00252.2012.-Repeated stimulation impacts neuronal responses. Here we show how

  3. The dialysis catheter and infectious peritonitis in intermittent peritoneal dialysis

    DEFF Research Database (Denmark)

    Kolmos, Hans Jørn; Hemmeløff Andersen, Karl Erik; Hansen, Lise

    1984-01-01

    118 episodes of infectious peritonitis registered among 156 patients treated with intermittent peritoneal dialysis over a 5-yr period were analysed with special reference to potential routes of infection associated with the dialysis catheter. Peritonitis was randomly distributed among the patients...

  4. Drug therapy for improving walking distance in intermittent claudication

    DEFF Research Database (Denmark)

    Momsen, Anne-Mette; Jensen, M B; Norager, C B

    2009-01-01

    To evaluate the efficacy of pharmacological interventions in improving walking capacity and health-related quality of life for people with intermittent claudication. DATASOURCES: We searched Medline, EMBASE, Cochrane library and relevant websites for studies published from the start of the databa...... of the databases to February 2009. In addition, reference lists were manually searched....

  5. The Role of Community Participation in Intermittent Preventive ...

    African Journals Online (AJOL)

    Very little attention was paid to community participation in malaria control in the past and this has affected most of the desired outcomes. The recent recognition of the importance of community participation in malaria control had informed the implementation of Intermittent Preventive Treatment of Childhood Malaria (IPTc).

  6. Scaling up Intermittent Rice Irrigation for Malaria Control on the ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The research aims to foster uptake of intermittent irrigation at the watershed level (Valle de Jequetepeque in La Libertad) by exploring ways to: - disseminate knowledge and skills (farmer-to-farmer agricultural extension); - assess and document social, health, environmental, and economic trade-offs as farmers adopt new ...

  7. Intermittent reservoir daily-inflow prediction using lumped and ...

    Indian Academy of Sciences (India)

    In this study, multi-linear regression (MLR) approach is used to construct intermittent reservoir daily inflow forecasting system. To illustrate the applicability and effect of using lumped and distributed input data in MLR approach, Koyna river watershed in Maharashtra, India is chosen as a case study. The results are also ...

  8. Evaluation of continuous and intermittent myocardial topical negative pressure

    DEFF Research Database (Denmark)

    Lindstedt, Sandra; Malmsjö, Malin; Gesslein, Bodil

    2008-01-01

    Topical negative pressure, commonly used in wound therapy, has been shown to increase blood flow and stimulate angiogenesis in subcutaneous tissue and skeletal muscle. In wound therapy, intermittent negative pressure is often preferred to continuous negative pressure as tissue exposed to intermit...

  9. Intermittency and multifractional Brownian character of geomagnetic time series

    Directory of Open Access Journals (Sweden)

    G. Consolini

    2013-07-01

    Full Text Available The Earth's magnetosphere exhibits a complex behavior in response to the solar wind conditions. This behavior, which is described in terms of mutifractional Brownian motions, could be the consequence of the occurrence of dynamical phase transitions. On the other hand, it has been shown that the dynamics of the geomagnetic signals is also characterized by intermittency at the smallest temporal scales. Here, we focus on the existence of a possible relationship in the geomagnetic time series between the multifractional Brownian motion character and the occurrence of intermittency. In detail, we investigate the multifractional nature of two long time series of the horizontal intensity of the Earth's magnetic field as measured at L'Aquila Geomagnetic Observatory during two years (2001 and 2008, which correspond to different conditions of solar activity. We propose a possible double origin of the intermittent character of the small-scale magnetic field fluctuations, which is related to both the multifractional nature of the geomagnetic field and the intermittent character of the disturbance level. Our results suggest a more complex nature of the geomagnetic response to solar wind changes than previously thought.

  10. Intermittency and multifractional Brownian character of geomagnetic time series

    Science.gov (United States)

    Consolini, G.; De Marco, R.; De Michelis, P.

    2013-07-01

    The Earth's magnetosphere exhibits a complex behavior in response to the solar wind conditions. This behavior, which is described in terms of mutifractional Brownian motions, could be the consequence of the occurrence of dynamical phase transitions. On the other hand, it has been shown that the dynamics of the geomagnetic signals is also characterized by intermittency at the smallest temporal scales. Here, we focus on the existence of a possible relationship in the geomagnetic time series between the multifractional Brownian motion character and the occurrence of intermittency. In detail, we investigate the multifractional nature of two long time series of the horizontal intensity of the Earth's magnetic field as measured at L'Aquila Geomagnetic Observatory during two years (2001 and 2008), which correspond to different conditions of solar activity. We propose a possible double origin of the intermittent character of the small-scale magnetic field fluctuations, which is related to both the multifractional nature of the geomagnetic field and the intermittent character of the disturbance level. Our results suggest a more complex nature of the geomagnetic response to solar wind changes than previously thought.

  11. Acute intermittent porphyria: Diagnostic dilemma and treatment options

    Science.gov (United States)

    Kaur, Mohan Deep; Hazarika, Nita; Saraswat, Namita; Sood, Rajesh

    2015-01-01

    Acute intermittent porphyria (AIP) presents with diverse group of symptoms making its early diagnosis difficult. Delaying diagnosis and treatment of AIP can be fatal or can cause long term or permanent neurological damage. We present here a case report of AIP where the diagnosis was missed. The diversity of symptoms and details concerning the treatment options for AIP are discussed. PMID:26330726

  12. Optimal Integration of Intermittent Renewables: A System LCOE Stochastic Approach

    Directory of Open Access Journals (Sweden)

    Carlo Lucheroni

    2018-03-01

    Full Text Available We propose a system level approach to value the impact on costs of the integration of intermittent renewable generation in a power system, based on expected breakeven cost and breakeven cost risk. To do this, we carefully reconsider the definition of Levelized Cost of Electricity (LCOE when extended to non-dispatchable generation, by examining extra costs and gains originated by the costly management of random power injections. We are thus lead to define a ‘system LCOE’ as a system dependent LCOE that takes properly into account intermittent generation. In order to include breakeven cost risk we further extend this deterministic approach to a stochastic setting, by introducing a ‘stochastic system LCOE’. This extension allows us to discuss the optimal integration of intermittent renewables from a broad, system level point of view. This paper thus aims to provide power producers and policy makers with a new methodological scheme, still based on the LCOE but which updates this valuation technique to current energy system configurations characterized by a large share of non-dispatchable production. Quantifying and optimizing the impact of intermittent renewables integration on power system costs, risk and CO 2 emissions, the proposed methodology can be used as powerful tool of analysis for assessing environmental and energy policies.

  13. Flow intermittence and ecosystem services in rivers of the Anthropocene

    Science.gov (United States)

    Intermittent rivers and ephemeral streams (IRES) are watercourses that cease flow at some point in time and space. Arguably Earth's most widespread type of flowing water, IRES are expanding where Anthropocenic climates grow drier and human demands for water escalate. However, IRE...

  14. Acute and intermittent testicular torsion: Analysis of presentation ...

    African Journals Online (AJOL)

    Background: Testicular torsion compromises the blood supply to the testes and may result in testicular loss or damage if not dealt with promptly. It can occur either as acute testicular torsion (ATT) or intermittent testicular torsion (ITT). This study examines the presentation, management, and outcome of adult testicular torsion.

  15. Muscular soreness following prolonged intermittent high-intensity shuttle running.

    Science.gov (United States)

    Thompson, D; Nicholas, C W; Williams, C

    1999-05-01

    The aim of this study was to examine the impact of prolonged intermittent high-intensity shuttle running on soreness and markers of muscle damage. Sixteen males took part in the study, half of whom were assigned to a running group and half to a resting control group. The exercise protocol involved 90 min of intermittent shuttle running and walking (Loughborough Intermittent Shuttle Test: LIST), reflecting the activity pattern found in multiple-sprint sports such as soccer. Immediately after exercise, there was a significant increase (P < 0.05) in serum activities of creatine kinase and aspartate aminotransferase, and values remained above baseline for 48 h (P < 0.05). Median peak activities of creatine kinase and aspartate aminotransferase occurred 24 h post-exercise and were 774 and 43 U x l(-1), respectively. The intensity of general muscle soreness, and in the specific muscles investigated, was greater than baseline for 72 h after the shuttle test (P < 0.05), peaking 24-48 h post-exercise (P < 0.05). Muscle soreness was not correlated with either creatine kinase or aspartate aminotransferase activity. Soreness was most frequently reported in the hamstrings. Neither soreness nor serum enzyme activity changed in the controls over the 4 day observation period. It appears that unaccustomed performance of prolonged intermittent shuttle running produces a significant increase in both soreness and markers of muscle damage.

  16. Therapeutic Efficacy of Intermittent Cryotherapy in the Management ...

    African Journals Online (AJOL)

    This study was therefore, designed to investigate the efficacy of intermittent cryotherapy in the management of pain among human subjects who sustained closed soft tissue injuries (CSTIs). Subjects' pre- and post-treatment pain perception scores (PPS) using visual analogue scale (VAS) and the sessions of treatment were ...

  17. Mathematical analysis of intermittent gas injection model in oil production

    Science.gov (United States)

    Tasmi, Silvya, D. R.; Pudjo, S.; Leksono, M.; Edy, S.

    2016-02-01

    Intermittent gas injection is a method to help oil production process. Gas is injected through choke in surface and then gas into tubing. Gas forms three areas in tubing: gas column area, film area and slug area. Gas column is used to propel slug area until surface. A mathematical model of intermittent gas injection is developed in gas column area, film area and slug area. Model is expanding based on mass and momentum conservation. Using assume film thickness constant in tubing, model has been developed by Tasmi et. al. [14]. Model consists of 10 ordinary differential equations. In this paper, assumption of pressure in gas column is uniform. Model consist of 9 ordinary differential equations. Connection of several variables can be obtained from this model. Therefore, dynamics of all variables that affect to intermittent gas lift process can be seen from four equations. To study the behavior of variables can be analyzed numerically and mathematically. In this paper, simple mathematically analysis approach is used to study behavior of the variables. Variables that affect to intermittent gas injection are pressure in upstream valve and in gas column. Pressure in upstream valve will decrease when gas mass in valve greater than gas mass in choke. Dynamic of the pressure in the gas column will decrease and increase depending on pressure in upstream valve.

  18. Peripheral arterial disease and intermittent claudication: Efficacy of ...

    African Journals Online (AJOL)

    Objective. To compare the effect of two training programmes and advice to exercise at home on physiological adaptations in patients with peripheral arterial disease (PAD). Design. 30 patients with a typical history of PAD and intermittent claudication were randomised to either an upper body strength training programme ...

  19. Safety of supervised exercise therapy in patients with intermittent claudication

    NARCIS (Netherlands)

    Gommans, Lindy N. M.; Fokkenrood, Hugo J. P.; van Dalen, Hendrika C. W.; Scheltinga, Marc R. M.; Teijink, Joep A. W.; Peters, Ron J. G.

    2015-01-01

    Supervised exercise therapy (SET) is recommended as the primary treatment for patients with intermittent claudication (IC). However, there is concern regarding the safety of performing SET because IC patients are at risk for untoward cardiovascular events. The Dutch physical therapy guideline

  20. Optimizing supervised exercise therapy for patients with intermittent claudication

    NARCIS (Netherlands)

    Nicolaï, Saskia P A; Hendriks, Erik J M; Prins, Martin H; Teijink, Joep A W; van Asselt, Thea

    2010-01-01

    BACKGROUND: The first-line intervention for intermittent claudication is usually supervised exercise therapy (SET). The literature describes a range of exercise programs varying in setting, duration, and content. The purpose of the present study was to examine the exercise protocols offered and to

  1. Design feasibility of an intermittent domestic energy store

    Energy Technology Data Exchange (ETDEWEB)

    Tahat, M.A. [Jordan Univ. of Sceince and Technology, Irbid (Jordan). Dept. of Mechanical Engineering; Babus`Haq, R.F.; O`Callaghan, P.W.; Probert, S.D. [Cranfield Univ., Bedford (United Kingdom). Dept. of Applied Energy

    1995-09-01

    In recent years, energy storage has been recognised as a potentially significant means by which primary energy consumption can be reduced in domestic, commercial and industrial processes. An intermittent domestic thermochemical heat pump, with a 5 kW{sub e} electric power output when employed as an energy store, is proposed. Different design options have been considered and their economic feasibilities evaluated. (author)

  2. Investigation of Intermittent Resistive Faults in Digital CMOS Circuits

    NARCIS (Netherlands)

    Kerkhoff, Hans G.; Ebrahimi, Hassan

    No fault found (NFF) is a major threat in extremely dependable high-end process node integrated systems, in e.g., avionics. One category of NFFs is the intermittent resistive fault (IRF), often originating from bad (e.g., via- or TSV-based) interconnections. This paper will show the impact of these

  3. Randomized double-blind placebo-controlled crossover study of caffeine in patients with intermittent claudication

    DEFF Research Database (Denmark)

    Momsen, A H; Jensen, M B; Norager, C B

    2010-01-01

    Intermittent claudication is a disabling symptom of peripheral arterial disease for which few medical treatments are available. This study investigated the effect of caffeine on physical capacity in patients with intermittent claudication.......Intermittent claudication is a disabling symptom of peripheral arterial disease for which few medical treatments are available. This study investigated the effect of caffeine on physical capacity in patients with intermittent claudication....

  4. Intermittent Anisotropic Turbulence Detected by THEMIS in the Magnetosheath

    Science.gov (United States)

    Macek, W. M.; Wawrzaszek, A.; Kucharuk, B.; Sibeck, D. G.

    2017-12-01

    Following our previous study of Time History of Events and Macroscale Interactions during Substorms (THEMIS) data, we consider intermittent turbulence in the magnetosheath depending on various conditions of the magnetized plasma behind the Earth’s bow shock and now also near the magnetopause. Namely, we look at the fluctuations of the components of the Elsässer variables in the plane perpendicular to the scale-dependent background magnetic fields and along the local average ambient magnetic fields. We have shown that Alfvén fluctuations often exhibit strong anisotropic non-gyrotropic turbulent intermittent behavior resulting in substantial deviations of the probability density functions from a normal Gaussian distribution with a large kurtosis. In particular, for very high Alfvénic Mach numbers and high plasma beta, we have clear anisotropy with non-Gaussian statistics in the transverse directions. However, along the magnetic field, the kurtosis is small and the plasma is close to equilibrium. On the other hand, intermittency becomes weaker for moderate Alfvén Mach numbers and lower values of the plasma parameter beta. It also seems that the degree of intermittency of turbulence for the outgoing fluctuations propagating relative to the ambient magnetic field is usually similar as for the ingoing fluctuations, which is in agreement with approximate equipartition of energy between these oppositely propagating Alfvén waves. We believe that the different characteristics of this intermittent anisotropic turbulent behavior in various regions of space and astrophysical plasmas can help identify nonlinear structures responsible for deviations of the plasma from equilibrium.

  5. Demographics and frequency of the intermittently upturned omentum at CT

    International Nuclear Information System (INIS)

    Penn, Alex; Wang, Wilbur; Wang, Zhen Jane; Yee, Judy; Webb, Emily M.; Yeh, Benjamin M.

    2013-01-01

    Objectives: To describe the demographics and frequency of the intermittently upturned omentum at CT. Methods: We retrospectively reviewed abdominal CT scans of 336 consecutive patients (189 men and 147 women) who were imaged between June 1 and June 17, 2010 and who had prior comparison scans. Readers recorded the presence or absence of an intermittently upturned omentum, defined as a thick rind of fat interposed between the liver and the anterior abdominal wall seen on one but not the other scan. At chart review, we recorded patient demographics and other clinical characteristics (prior surgical history, presence of cirrhosis). Results: An intermittently upturned omentum was found in 10 of 336 (3.0%) patients. An intermittently upturned omentum was seen more commonly in men than in women (9 of 189 men, or 4.8% versus 1 of 147 women, or 0.7%, p = 0.047) and in cirrhotics (4 of 37 cirrhotics, or 10.8% versus 6 of 299 non-cirrhotics, or 2.0%, p = 0.023). In a sub-analysis of patients without prior abdominal surgery, this finding was again seen more commonly in men than women (7 of 163 men, or 4.3% versus 0 of 134 women, or 0%, p = 0.018) and in cirrhotics (3 of 33 cirrhotics, or 9.1% versus 4 of 264 non-cirrhotics, or 1.5%, p = 0.032). Conclusions: An intermittently upturned omentum is not uncommon and is more frequently seen in men and in patients with cirrhosis who may have a larger anterior hepatic space

  6. Observation of intermittency in gene expression on cDNA microarrays

    CERN Document Server

    Peterson, L E

    2002-01-01

    We used scaled factorial moments to search for intermittency in the log expression ratios (LERs) for thousands of genes spotted on cDNA microarrays (gene chips). Results indicate varying levels of intermittency in gene expression. The observation of intermittency in the data analyzed provides a complimentary handle on moderately expressed genes, generally not tackled by conventional techniques.

  7. Optimization of the rapping process of an intermittent electrostatic precipitator

    Science.gov (United States)

    Miloua, F.; Tilmatine, A.; Gouri, R.; Kadous, N.; Dascalescu, L.

    2008-01-01

    Intermittent operation mode is specific to electrostatic precipitators (ESP) used in workshops where the polluting product is produced in a discontinuous way. The rapping system is necessary in order to ensure a continuous and effective operation of a dry electrostatic precipitator, but causes at the same time, a problem of re-entrainment of dust and thus the degradation of filtration efficiency. The objective of this paper is to propose a procedure based on the methodology of experimental designs (Tagushi's Methodology) aiming at optimizing the rapping process; it consists to determine optimal values of rapping, i.e. the moment, the position and the force of rapping. Several “one-factor-at-a-time" experimental designs followed by a Full Factorial design, made it possible to model the process and to analyze interactions between the factors. The experiments were carried out on a laboratory experimental device which simulates an industrial precipitator with intermittent operation.

  8. Managing intermittent energy for generating electricity on islands

    International Nuclear Information System (INIS)

    Mahiou, Bernard

    2013-01-01

    France's 'electric islands' are the overseas departments and Corsica that have small, isolated grids in 'zones not interconnected' (ZNI) with the continental grid. What characterizes them is the strong growth of consumption and the quite high cost of electricity, the latter heavily subsidized through arrangements under the legal obligation to 'contribute to the public service of electricity'. Renewable, intermittent forms of energy (especially photovoltaic) have grown exponentially on these islands since 2008 thanks to the backing of public policies for setting objectives, tax exemptions, and the rates for purchasing the electricity thus generated. Owing to several experiments under way, the ZNIs have become laboratories for anticipating the future difficulties that interconnected electricity grids will have to handle once the share of renewable, intermittent electricity will have risen significantly in the energy mix

  9. Intermittency and local heating in the solar wind.

    Science.gov (United States)

    Osman, K T; Matthaeus, W H; Wan, M; Rappazzo, A F

    2012-06-29

    Evidence for nonuniform heating in the solar wind plasma near current sheets dynamically generated by magnetohydrodynamic (MHD) turbulence is obtained using measurements from the ACE spacecraft. These coherent structures only constitute 19% of the data, but contribute 50% of the total plasma internal energy. Intermittent heating manifests as elevations in proton temperature near current sheets, resulting in regional heating and temperature enhancements extending over several hours. The number density of non-Gaussian structures is found to be proportional to the mean proton temperature and solar wind speed. These results suggest magnetofluid turbulence drives intermittent dissipation through a hierarchy of coherent structures, which collectively could be a significant source of coronal and solar wind heating.

  10. Intermittent magnetic reconnection in TS-3 merging experiment

    International Nuclear Information System (INIS)

    Ono, Y.; Hayashi, Y.; Ii, T.; Tanabe, H.; Ito, S.; Kuwahata, A.; Ito, T.; Kamino, Y.; Yamada, T.; Inomoto, M.

    2011-01-01

    Ejection of current sheet with plasma mass causes impulsive and intermittent magnetic reconnection in the TS-3 spherical tokamak (ST) merging experiment. Under high guide toroidal field, the sheet resistivity is almost classical due to the sheet thickness much longer than the ion gyroradius. Large inflow flux and low current-sheet resistivity result in flux and plasma pileup followed by rapid growth of the current sheet. When the pileup exceeds a critical limit, the sheet is ejected mechanically from the squeezed X-point area. The reconnection (outflow) speed is slow during the flux/plasma pileup and is fast during the ejection, suggesting that intermittent reconnection similar to the solar flare increases the averaged reconnection speed. These transient effects enable the merging tokamaks to have the fast reconnection as well as the high-power reconnection heating, even when their current-sheet resistivity is low under high guide field.

  11. Observation of intermittent transition by electrode biasing in Heliotron J

    International Nuclear Information System (INIS)

    Shimizu, Kosuke; Kitajima, Sumio; Okamoto, Atsushi

    2015-01-01

    We observed intermittent increases in the electrode current in electrode biasing experiments in Heliotron J. In addition, electron density and floating potential showed pulsating behavior associated with the electrode current. The relation between line density and electrode current and that between floating potential and electrode current showed a hysteresis feature in transitions. Then it is evident that the pulsating behavior was the intermittent transition between two distinctive states. We also observed the mode (∼10 kHz) that accompanied the pulsating behavior in the power spectrum density of the floating potential and ion saturation current obtained via fast Fourier transform. The electron density gradient increased, and subsequently the power spectrum density of the fluctuation increased. (author)

  12. Environmental heat stress, hyperammonemia and nucleotide metabolism during intermittent exercise

    DEFF Research Database (Denmark)

    Mohr, Magni; Rasmussen, Peter; Drust, Barry

    2006-01-01

    Abstract  This study investigated the influence of environmental heat stress on ammonia (NH3) accumulation in relation to nucleotide metabolism and fatigue during intermittent exercise. Eight males performed 40 min of intermittent exercise (15 s at 306±22 W alternating with 15 s of unloaded cycling......) followed by five 15 s all-out sprints. Control trials were conducted in a 20°C environment while heat stress trials were performed at an ambient temperature of 40°C. Muscle biopsies and venous blood samples were obtained at rest, after 40 min of exercise and following the maximal sprints. Following...... exercise with heat stress, the core and muscle temperatures peaked at 39.5±0.2 and 40.2±0.2°C to be ~ 1°C higher (Pstress trial (P

  13. Elastically driven intermittent microscopic dynamics in soft solids

    Science.gov (United States)

    Bouzid, Mehdi; Colombo, Jader; Barbosa, Lucas Vieira; Del Gado, Emanuela

    2017-06-01

    Soft solids with tunable mechanical response are at the core of new material technologies, but a crucial limit for applications is their progressive aging over time, which dramatically affects their functionalities. The generally accepted paradigm is that such aging is gradual and its origin is in slower than exponential microscopic dynamics, akin to the ones in supercooled liquids or glasses. Nevertheless, time- and space-resolved measurements have provided contrasting evidence: dynamics faster than exponential, intermittency and abrupt structural changes. Here we use 3D computer simulations of a microscopic model to reveal that the timescales governing stress relaxation, respectively, through thermal fluctuations and elastic recovery are key for the aging dynamics. When thermal fluctuations are too weak, stress heterogeneities frozen-in upon solidification can still partially relax through elastically driven fluctuations. Such fluctuations are intermittent, because of strong correlations that persist over the timescale of experiments or simulations, leading to faster than exponential dynamics.

  14. Continuous use of intermittent bladder catheterization - can social support contribute?

    Directory of Open Access Journals (Sweden)

    Marjoyre Anne Lindozo Lopes

    2014-06-01

    Full Text Available OBJECTIVE: to investigate the factors affecting the adequate continuous use of intermittent catheterization and its relation with social support.METHOD: sectional, descriptive and correlational study involving 49 patients with neuropathic bladder caused by spinal cord injury.RESULTS: almost all (92% participants continued the intermittent catheterization, but 46.9% made some changes in the technique. The complications (28.6% of the sample were mainly infection and vesicolithiasis. There were high scores for social support in relation to people that were part of the patient's social support.CONCLUSION: All of them noticed great support from the family, but not from the society in general. The difficulties were related to the lack of equipment and inadequate infrastructure, leading to changes that increased urologic complications.

  15. Mars Atmospheric Entry Integrated Navigation with Partial Intermittent Measurements

    Directory of Open Access Journals (Sweden)

    Tai-shan Lou

    2017-01-01

    Full Text Available Signal degradation suffered by the vehicle is a combination brownout and blackout during Mars atmospheric entry. The communications brownout means that signal fades and blackout means that the signal is lost completely. The communications brownout and blackout periods are analyzed and predicted with an altitude and velocity profiles. In the brownout period, the range measurements between the vehicle and the orbiters are modeled as intermittent measurements with the radio signal arrival probabilities, which are distributed as a Rayleigh distribution of the electron number density around the entry vehicle. A new integrated navigation strategy during the Mars atmospheric entry phase is proposed to consider the probabilities of the radio measurements in the communications brownout and blackout periods under the IMU/beacon scenario based on the information filter with intermittent measurements. Numerical navigation simulations are designed to show the performance of the proposed navigation strategy under the integrated navigation scenario.

  16. Considering Intermittent Dormancy in an Advanced Life Support Systems Architecture

    Science.gov (United States)

    Sargusingh, Miriam J.; Perry, Jay L.

    2017-01-01

    Many advanced human space exploration missions being considered by the National Aeronautics and Space Administration (NASA) include concepts in which in-space systems cycle between inhabited and uninhabited states. Managing the life support system (LSS) may be particularly challenged during these periods of intermittent dormancy. A study to identify LSS management challenges and considerations relating to dormancy is described. The study seeks to define concepts suitable for addressing intermittent dormancy states and to evaluate whether the reference LSS architectures being considered by the Advanced Exploration Systems (AES) Life Support Systems Project (LSSP) are sufficient to support this operational state. The primary focus of the study is the mission concept considered to be the most challenging-a crewed Mars mission with an extensive surface stay. Results from this study are presented and discussed.

  17. Kullback-Leibler divergence measure of intermittency: Application to turbulence

    Science.gov (United States)

    Granero-Belinchón, Carlos; Roux, Stéphane G.; Garnier, Nicolas B.

    2018-01-01

    For generic systems exhibiting power law behaviors, and hence multiscale dependencies, we propose a simple tool to analyze multifractality and intermittency, after noticing that these concepts are directly related to the deformation of a probability density function from Gaussian at large scales to non-Gaussian at smaller scales. Our framework is based on information theory and uses Shannon entropy and Kullback-Leibler divergence. We provide an extensive application to three-dimensional fully developed turbulence, seen here as a paradigmatic complex system where intermittency was historically defined and the concepts of scale invariance and multifractality were extensively studied and benchmarked. We compute our quantity on experimental Eulerian velocity measurements, as well as on synthetic processes and phenomenological models of fluid turbulence. Our approach is very general and does not require any underlying model of the system, although it can probe the relevance of such a model.

  18. INTERMITTENT ANTIARYTHMIC THERAPY OF ARIOVENTICULAR NODAL REENTRY TACHYCARDIA IN CHILDREN

    Directory of Open Access Journals (Sweden)

    Boris Djindjic

    2008-04-01

    Full Text Available Until recent advances in pharmacology and clinical cardiology regarding farmacodynamics of antiarrhythmic drugs and their efficiency in patients with refractory paroxysmal supraventricular tachycardia, chronic prophylactic therapy was the only treatment option for patients refusing catheter ablation. Another treatment option, also known by eponym “pill in pocket” have been shown to be equally useful and efficacious.The aim of our study was prospective examination of children with refractory atrioventricular nodal reentry tachycardia (AVNRT who were withdrawn from chronic antiarrhythmic prophylactic therapy and started with intermittent oral beta blocker treatment (propranolol at dosage 1 mg/kg - max 80 mg.Twelve children (8 boys and 4 girls with AVNRT were included in the study. Four children did not have arrhythmia during first six months after withdrawal and 7 were successfully treated without complication.Intermittent antiarrhythmic therapy in children with AVNRT could be very efficacious and useful treatment option which significantly improves their quality of life.

  19. Thermal degradation of groundnut oil during continuous and intermittent frying.

    Science.gov (United States)

    Das, Amit K; Babylatha, R; Pavithra, A S; Khatoon, Sakina

    2013-12-01

    The quality of refined groundnut oil, as affected by frying Poori, was assessed with respect to two types of frying operations viz., continuous frying and intermittent frying. Continuous frying was carried out consistently for 8 h, whereas intermittent frying was performed for 2 h everyday for 4 days for a total of 8 frying hours. The purpose of the study was to compare the level of deterioration that occurred during the two operations. Among the parameters studied, peroxide value (11.3 ± 0.26 meqO2/kg), anisidine value (172.4 ± 2.71), diene value (1.57 ± 0.095), oxidized fatty acid (2.6 ± 0.17%) and viscosity (103.8 ± 2.5 mPa s(-1)), were found to be higher after 8 h due to intermittent frying. The corresponding values 4.9 ± 0.15, 133.3 ± 0.49, 0.811 ± 0.04, 0.38 ± 0.023 and 81.8 ± 2.02 were observed in continuous frying. Parameters such as iodine value, unsaturated fatty acids, saponification value and smoke point decreased significantly (P frying. Results showed that intermittent frying caused more quality degradation to GNO than continuous frying.

  20. Intermittent fasting during Ramadan: does it affect sleep?

    Science.gov (United States)

    Bahammam, Ahmed S; Almushailhi, Khalid; Pandi-Perumal, Seithikurippu R; Sharif, Munir M

    2014-02-01

    Islamic intermittent fasting is distinct from regular voluntary or experimental fasting. We hypothesised that if a regimen of a fixed sleep-wake schedule and a fixed caloric intake is followed during intermittent fasting, the effects of fasting on sleep architecture and daytime sleepiness will be minimal. Therefore, we designed this study to objectively assess the effects of Islamic intermittent fasting on sleep architecture and daytime sleepiness. Eight healthy volunteers reported to the Sleep Disorders Centre on five occasions for polysomnography and multiple sleep latency tests: (1) during adaptation; (2) 3 weeks before Ramadan, after having performed Islamic fasting for 1 week (baseline fasting); (3) 1 week before Ramadan (non-fasting baseline); (4) 2 weeks into Ramadan (Ramadan); and (5) 2 weeks after Ramadan (non-fasting; Recovery). Daytime sleepiness was assessed using the Epworth Sleepiness Scale and the multiple sleep latency test. The participants had a mean age of 26.6 ± 4.9 years, a body mass index of 23.7 ± 3.5 kg m(-2) and an Epworth Sleepiness Scale score of 7.3 ± 2.7. There was no change in weight or the Epworth Sleepiness Scale in the four study periods. The rapid eye movement sleep percentage was significantly lower during fasting. There was no difference in sleep latency, non-rapid eye movement sleep percentage, arousal index and sleep efficiency. The multiple sleep latency test analysis revealed no difference in the sleep latency between the 'non-fasting baseline', 'baseline fasting', 'Ramadan' and 'Recovery' time points. Under conditions of a fixed sleep-wake schedule and a fixed caloric intake, Islamic intermittent fasting results in decreased rapid eye movement sleep with no impact on other sleep stages, the arousal index or daytime sleepiness. © 2013 European Sleep Research Society.

  1. Consensus of Multiagent Networks with Intermittent Interaction and Directed Topology

    Directory of Open Access Journals (Sweden)

    Li Xiao

    2014-01-01

    Full Text Available Intermittent interaction control is introduced to solve the consensus problem for second-order multiagent networks due to the limited sensing abilities and environmental changes periodically. And, we get some sufficient conditions for the agents to reach consensus with linear protocol from the theoretical findings by using the Lyapunov control approach. Finally, the validity of the theoretical results is validated through the numerical example.

  2. Verbal versus Physical Aggression in Intermittent Explosive Disorder

    OpenAIRE

    Look, Amy E.; McCloskey, Michael S.; Coccaro, Emil F.

    2014-01-01

    Intermittent Explosive Disorder (IED) is the only adult psychiatric diagnosis for which pathological aggression is primary. DSM-IV criteria focused on physical aggression, but DSM-5 allows for an IED diagnosis in the presence of frequent verbal aggression with or without concurrent physical aggression. It remains unclear how individuals with verbal aggression differ from those with physical aggression with respect to cognitive-affective deficits and psychosocial functioning. The current study...

  3. Intermittency route to chaos in a biochemical system.

    Science.gov (United States)

    De la Fuente, I M; Martinez, L; Veguillas, J

    1996-01-01

    The numerical analysis of a glycolytic model performed through the construction of a system of three differential-delay equations reveals a phenomenon of intermittency route to chaos. In our biochemical system, the consideration of delay time variations under constant input flux as well as frequency variations of the periodic substrate input flux allows us, in both cases, to observe a type of transition to chaos different from the 'Feigenbaum route'.

  4. Sand intermittent filtration technology for safer domestic sewage ...

    African Journals Online (AJOL)

    Maximum pollution reduction potential of intermittent filtration bed was recorded at 2 feet depth of sand and soil mixture at ratio of 3:1. Percentage of pollution reducing potential was found in CO2 83.4%, BOD 72.5%, COD 69.9%, Total alkalinity 37.9%, Total solids 88.5%, Total dissolved solids 86.1%, Total suspended solids ...

  5. Intermittent bisphosphonate therapy in postmenopausal osteoporosis - Progress to date

    OpenAIRE

    Reginster, Jean-Yves; Malaise, Olivier; Neuprez, A.; Jouret, V. E.; Close, Pierre

    2007-01-01

    Bisphosphonates are the most widely prescribed drugs in osteoporosis today. They have unequivocally shown their ability to reduce fracture rate at the spine (alendronic acid, risedronic acid, ibandronic acid) and at the hip (alendronic acid and risedronic acid). However, their dosage and administration procedures and the adverse reactions induced by their oral intake are responsible for low adherence. Therefore, intermittent regimens have been developed. Weekly alendronic acid and risedronic ...

  6. The stochastic dynamics of intermittent porescale particle motion

    Science.gov (United States)

    Dentz, Marco; Morales, Veronica; Puyguiraud, Alexandre; Gouze, Philippe; Willmann, Matthias; Holzner, Markus

    2017-04-01

    Numerical and experimental data for porescale particle dynamics show intermittent patterns in Lagrangian velocities and accelerations, which manifest in long time intervals of low and short durations of high velocities [1, 2]. This phenomenon is due to the spatial persistence of particle velocities on characteristic heterogeneity length scales. In order to systematically quantify these behaviors and extract the stochastic dynamics of particle motion, we focus on the analysis of Lagrangian velocities sampled equidistantly along trajectories [3]. This method removes the intermittency observed under isochrone sampling. The space-Lagrangian velocity series can be quantified by a Markov process that is continuous in distance along streamline. It is fully parameterized in terms of the flux-weighted Eulerian velocity PDF and the characteristic pore-length. The resulting stochastic particle motion describes a continuous time random walk (CTRW). This approach allows for the process based interpretation of experimental and numerical porescale velocity, acceleration and displacement data. It provides a framework for the characterization and upscaling of particle transport and dispersion from the pore to the Darcy-scale based on the medium geometry and Eulerian flow attributes. [1] P. De Anna, T. Le Borgne, M. Dentz, A.M. Tartakovsky, D. Bolster, and P. Davy, "Flow intermittency, dispersion, and correlated continuous time random walks in porous media," Phys. Rev. Lett. 110, 184502 (2013). [2] M. Holzner, V. L. Morales, M. Willmann, and M. Dentz, "Intermittent Lagrangian velocities and accelerations in three- dimensional porous medium flow," Phys. Rev. E 92, 013015 (2015). [3] M. Dentz, P. K. Kang, A. Comolli, T. Le Borgne, and D. R. Lester, "Continuous time random walks for the evolution of Lagrangian velocities," Phys. Rev. Fluids (2016).

  7. Prolapsed bilateral ureteroceles leading to intermittent outflow obstruction.

    LENUS (Irish Health Repository)

    Stunell, H

    2012-02-01

    A ureterocele refers to a cystic dilatation of the distal ureter. It may be unilateral or bilateral and may be associated with a duplex system in some cases. We present an unusual case where a young patient was found to have large bilateral ureteroceles which prolapsed into the urethra, causing intermittent incontinence and obstruction. We discuss the case and review the literature concerning this rare anomaly.

  8. Adaptations with Intermittent Exercise Training in Post- and Premenopausal Women.

    Science.gov (United States)

    Seidelin, Kåre; Nyberg, Michael; Piil, Peter; Jørgensen, Niklas Rye; Hellsten, Ylva; Bangsbo, Jens

    2017-01-01

    The purposes of the present study was to examine the effect of intermittent exercise training on musculoskeletal and metabolic health in postmenopausal (PM) and premenopausal (PRM) women and, furthermore, to evaluate whether the adaptations can be maintained with a reduced training frequency. Eighteen PM (51 ± 1 yr, mean ± SEM) and 12 PRM (48 ± 1 yr) women participated in floorball training approximately two times per week for 12 wk. In a subgroup (n = 9) of PM women (PM40), exercise training was performed for an additional 40 wk with a reduced training frequency of approximately one training session per week. In PM, the body fat percentage decreased (P < 0.05) and the total lean leg mass increased (P < 0.05) during the 12-wk training period, with no changes in PRM. In both PM and PRM, lean body mass and maximal oxygen uptake (V˙O2max) were higher, and Yo-Yo intermittent endurance test 1 (YYIET-1) performance was better (P < 0.05) after the 12-wk training period. Procollagen type 1 amino-terminal propeptide was higher (P < 0.05) in PM, and total leg bone mineral density (BMD) was higher (P < 0.05) in both PM and PRM after the 12-wk training period. In PM40, total lean leg mass, V˙O2max, YYIET-1 performance, level of procollagen type 1 amino-terminal propeptide, and total leg BMD were maintained, whereas whole-body BMD and glycated hemoglobin (HbA1c) were reduced (P < 0.05) and the expression of muscle glucose transporter type 4 was higher (P < 0.05). Twelve weeks of intermittent exercise training increased BMD, intermittent exercise capacity, and V˙O2max in PM and PRM, with PM also having positive changes in body composition. Additional 40 wk of training with a reduced frequency was sufficient to preserve these physiological adaptations and also improve blood glucose regulation in PM.

  9. Prolapsing Gastric Polyp Causing Intermittent Gastric Outlet Obstruction.

    Science.gov (United States)

    Kosai, Nik Ritza; Gendeh, Hardip Singh; Norfaezan, Abdul Rashid; Razman, Jamin; Sutton, Paul Anthony; Das, Srijit

    2015-06-01

    Gastric polyps are often an incidental finding on upper gastrointestinal endoscopy, with an incidence up to 5%. The majority of gastric polyps are asymptomatic, occurring secondary to inflammation. Prior reviews discussed Helicobacter pylori (H pylori)-associated singular gastric polyposis; however, we present a rare and unusual case of recurrent multiple benign gastric polyposis post H pylori eradication resulting in intermittent gastric outlet obstruction. A 70-year-old independent male, Chinese in ethnicity, with a background of diabetes mellitus, hypertension, and a simple renal cyst presented with a combination of melena, anemia, and intermittent vomiting of partially digested food after meals. Initial gastroscopy was positive for H pylori; thus he was treated with H pylori eradication and proton pump inhibitors. Serial gastroscopy demonstrated multiple sessile gastric antral polyps, the largest measuring 4 cm. Histopathologic examination confirmed a benign hyperplastic lesion. Computed tomography identified a pyloric mass with absent surrounding infiltration or metastasis. A distal gastrectomy was performed, whereby multiple small pyloric polyps were found, the largest prolapsing into the pyloric opening, thus explaining the intermittent nature of gastric outlet obstruction. Such polyps often develop from gastric ulcers and, if left untreated, may undergo neoplasia to form malignant cells. A distal gastrectomy was an effective choice of treatment, taking into account the polyp size, quantity, and potential for malignancy as opposed to an endoscopic approach, which may not guarantee a complete removal of safer margins and depth. Therefore, surgical excision is favorable for multiple large gastric polyps with risk of malignancy.

  10. Multiparticle correlations and intermittency in high energy collisions

    International Nuclear Information System (INIS)

    Bozek, P.

    1992-01-01

    An analysis of the intermittency signal observed in high energy experiments is presented using multiparticle distributions and correlation functions. The effect of the dimensional projection of the multiparticle distributions on one or two-dimensional subspace is discussed. The structure of the multiparticle cumulants is analyzed for the DELPHI e + e - annihilation data. The model of spatiotemporal intermittency is discussed in details and is shown to reproduce qualitatively the dependence of the intermittency strength on the target and projectile nuclei. A 1-dimensional (lD) cellular-automaton (CA) and a lD forest-fire model is studied. On the example of the noncritical lD Ising model the difficulties of the scaled factorial moment (SFM) method in extracting genuine scaling behaviour are illustrated. The problem of the finite-size effect in connection to the dimensional projection can be easily exemplified in the case of the 2D critical system with conformal symmetry. (R.P.) 122 refs., 38 figs., 3 tabs

  11. Detection and localization of multiple wideband intermittent acoustic sources

    Science.gov (United States)

    Hudson, R. E.; Yao, K.; Hedley, R.; Taylor, C. E.

    2017-05-01

    We have been interested in the analytical and experimental study of real-life bird song sources for several years. Bird sources are characterized by either a single or multiple bird vocalizations independent of each other or in response to others. The sources may be physically-stationary or exhibit movements and the signals are wide-band in frequency and often intermittent with pauses and possibly restarting with repeating previously used songs or with new songs. Thus, the detection, classification, and 2D or 3D localization of these birds pose challenging signal and array problems. Due to the fact that some birds can mimic other birds, time-domain waveform characterization may not be sufficient for determining the number of birds. Similarly, due to the intermittent nature of the vocalizations, data collected over a long period cannot be used naively. Thus, it is necessary to use short-time Fourier transform (STFT) to fully exploit the intricate natures of the time and frequency properties of these sources and displayed on a spectrogram. Various dominant spectral data over the relevant frames are used to form sample covariance matrices. Eigenvectors associated with the decompositions of these matrices for these spectral indices can be used to provide 2D/3D DOA estimations of the sources over different frames for intermittent sources. Proper cluttering of these data can be used to perform enhanced detection, classification, and localization of multiple bird sources. Two sets of collected bird data will be used to demonstrate these claims.

  12. Remote ischemic preconditioning in patients with intermittent claudication

    Directory of Open Access Journals (Sweden)

    Glauco Fernandes Saes

    2013-04-01

    Full Text Available OBJECTIVE: Remote ischemic preconditioning (RIPC is a phenomenon in which a short period of sub-lethal ischemia in one organ protects against subsequent bouts of ischemia in another organ. We hypothesized that RIPC in patients with intermittent claudication would increase muscle tissue resistance to ischemia, thereby resulting in an increased ability to walk. METHODS: In a claudication clinic, 52 ambulatory patients who presented with complaints of intermittent claudication in the lower limbs associated with an absent or reduced arterial pulse in the symptomatic limb and/or an ankle-brachial index <0.90 were recruited for this study. The patients were randomly divided into three groups (A, B and C. All of the patients underwent two tests on a treadmill according to the Gardener protocol. Group A was tested first without RIPC. Group A was subjected to RIPC prior to the second treadmill test. Group B was subjected to RIPC prior to the first treadmill test and then was subjected to a treadmill test without RIPC. In Group C (control group, both treadmill tests were performed without RIPC. The first and second tests were conducted seven days apart. Brazilian Clinical Trials: RBR-7TF6TM. RESULTS: Group A showed a significant increase in the initial claudication distance in the second test compared to the first test. CONCLUSION: RIPC increased the initial claudication distance in patients with intermittent claudication; however, RIPC did not affect the total walking distance of the patients.

  13. Effect of warm-up on intermittent sprint performance.

    Science.gov (United States)

    Anderson, P; Landers, G; Wallman, K

    2014-01-01

    We aimed to investigate the effects of different warm-up (WUP) intensities on 10 min of subsequent intermittent-sprint running performance. Eleven male, team-sport players performed four trials in a randomized, cross-over design, consisting of an intermittent-sprint protocol (15 × 20-m sprints) that followed either no-WUP or one of three 10-min WUP trials that varied in intensity. Warm-up intensities were performed at either (1) half the difference between anaerobic threshold (AT) and lactate threshold (LT) [(AT-LT)/2] below the LT = WUP 1; (2) midway between LT and AT level = WUP 2; (3) [(AT-LT)/2] above AT = WUP 3. Sprint times were fastest following WUP 3, compared with all other trials, for sprints 1-9 and 14, as well as for total accumulated sprints, with these results supported by moderate to large effect size (ES; range: d = -0.50 to -1.06) and "possible" to "almost certain" benefits. Warm-up 3 resulted in faster intermittent-sprint running performance compared with lower intensity WUPs and no WUP for the first 6 min of sprinting, with accumulated sprints for the entire 10 min protocol also being faster after WUP 3. This information may be pertinent to coaches of team-sport games with respect to player substitutions.

  14. New advances on chaotic intermittency and its applications

    CERN Document Server

    Elaskar, Sergio

    2017-01-01

    One of the most important routes to chaos is the chaotic intermittency. However, there are many cases that do not agree with the classical theoretical predictions. In this book, an extended theory for intermittency in one-dimensional maps is presented. A new general methodology to evaluate the reinjection probability density function (RPD) is developed in Chapters 5 to 8. The key of this formulation is the introduction of a new function, called M(x), which is used to calculate the RPD function. The function M(x) depends on two integrals. This characteristic reduces the influence on the statistical fluctuations in the data series. Also, the function M(x) is easy to evaluate from the data series, even for a small number of numerical or experimental data. As a result, a more general form for the RPD is found; where the classical theory based on uniform reinjection is recovered as a particular case. The characteristic exponent traditionally used to characterize the intermittency type, is now a function depending ...

  15. Acute intermittent hypoxia induced neural plasticity in respiratory motor control.

    Science.gov (United States)

    Xing, Tao; Fong, Angelina Y; Bautista, Tara G; Pilowsky, Paul M

    2013-09-01

    Respiratory neural networks can adapt to rapid environmental change or be altered over the long term by various inputs. The mechanisms that underlie the plasticity necessary for adaptive changes in breathing remain unclear. Acute intermittent hypoxia (AIH)-induced respiratory long-term facilitation (LTF) is one of the most extensively studied types of respiratory plasticity. Acute intermittent hypoxia-induced LTF is present in several respiratory motor outputs, innervating both pump muscles (i.e. diaphragm) and valve muscles (i.e. tongue, pharynx and larynx). Long-term facilitation is present in various species, including humans, and the expression of LTF is influenced by gender, age and genetics. Serotonin plays a key role in initiating and modulating plasticity at the level of respiratory motor neurons. Recently, multiple intracellular pathways have been elucidated that are capable of giving rise to respiratory LTF. These mainly activate the metabolic receptors coupled to Gq ('Q' pathway) and Gs ('S' pathway) proteins. Herein, we discuss AIH-induced respiratory LTF in animals and humans, as well as recent advances in our understanding of the synaptic and intracellular pathways underlying this form of plasticity. We also discuss the potential to use intermittent hypoxia to induce functional recovery following cervical spinal injury. © 2013 Wiley Publishing Asia Pty Ltd.

  16. Intermittency in small-scale turbulence: a velocity gradient approach

    Science.gov (United States)

    Meneveau, Charles; Johnson, Perry

    2017-11-01

    Intermittency of small-scale motions is an ubiquitous facet of turbulent flows, and predicting this phenomenon based on reduced models derived from first principles remains an important open problem. Here, a multiple-time scale stochastic model is introduced for the Lagrangian evolution of the full velocity gradient tensor in fluid turbulence at arbitrarily high Reynolds numbers. This low-dimensional model differs fundamentally from prior shell models and other empirically-motivated models of intermittency because the nonlinear gradient self-stretching and rotation A2 term vital to the energy cascade and intermittency development is represented exactly from the Navier-Stokes equations. With only one adjustable parameter needed to determine the model's effective Reynolds number, numerical solutions of the resulting set of stochastic differential equations show that the model predicts anomalous scaling for moments of the velocity gradient components and negative derivative skewness. It also predicts signature topological features of the velocity gradient tensor such as vorticity alignment trends with the eigen-directions of the strain-rate. This research was made possible by a graduate Fellowship from the National Science Foundation and by a Grant from The Gulf of Mexico Research Initiative.

  17. Sprint vs. intermittent training in young female basketball players.

    Science.gov (United States)

    Attene, G; Pizzolato, F; Calcagno, G; Ibba, G; Pinna, M; Salernitano, G; Padulo, J

    2014-04-01

    This study aimed at comparing the effects of intermittent and repeated sprint ability training on physiological variables. Sixteen young female basketball players were randomly allocated to intermittent training (IT=8) or repeated sprint ability training (RST=8) groups. The following outcomes were measured at baseline and after 6 weeks of training: Yo-Yo intermittent recovery (Yo-Yo) and repeated sprint ability (RSA) tests. For all the variables investigated the effect of training type showed a different trend respect at current knowledge. In the RSA, best time (BT) was a significant main effect of training time (pre- vs. post-) (Ptraining type/time (P=0.03). The RST showed a decrease in BT of 3.1% (P=0.005) while the IT showed a decrease of 6.2% (Ptraining methods used in this study can be an effective training strategy for inducing anaerobic and basketball-specific training schedules. Besides, even when IT training is not done at very high speed, it can increase the maximum speed of the RSA.

  18. Seizure tests distinguish intermittent fasting from the ketogenic diet.

    Science.gov (United States)

    Hartman, Adam L; Zheng, Xiangrong; Bergbower, Emily; Kennedy, Michiko; Hardwick, J Marie

    2010-08-01

    Calorie restriction can be anticonvulsant in animal models. The ketogenic diet was designed to mimic calorie restriction and has been assumed to work by the same mechanisms. We challenged this assumption by profiling the effects of these dietary regimens in mice subjected to a battery of acute seizure tests. Juvenile male NIH Swiss mice received ketogenic diet or a normal diet fed in restricted quantities (continuously or intermittently) for ∼12 days, starting at 3-4 weeks of age. Seizures were induced by the 6 Hz test, kainic acid, maximal electroshock, or pentylenetetrazol. The ketogenic and calorie-restricted diets often had opposite effects depending on the seizure test. The ketogenic diet protected from 6 Hz-induced seizures, whereas calorie restriction (daily and intermittent) increased seizure activity. Conversely, calorie restriction protected juvenile mice against seizures induced by kainic acid, whereas the ketogenic diet failed to protect. Intermittent caloric restriction worsened seizures induced by maximal electroshock but had no effect on those induced by pentylenetetrazol. In contrast to a longstanding hypothesis, calorie restriction and the ketogenic diet differ in their acute seizure test profiles, suggesting that they have different underlying anticonvulsant mechanisms. These findings highlight the importance of the 6 Hz test and its ability to reflect the benefits of ketosis and fat consumption. Wiley Periodicals, Inc. © 2010 International League Against Epilepsy.

  19. Lactate Kinetics After Intermittent and Continuous Exercise Training

    Science.gov (United States)

    Gharbi, Adnene; Chamari, Karim; Kallel, Amjad; Ahmaidi, Saîd; Tabka, Zouhair; Abdelkarim, Zbidi

    2008-01-01

    The purpose of this study was to assess, the effects of continuous and intermittent exercise training on lactate kinetic parameters and maximal aerobic speed (MAS) using field tests. Twenty-four male sport students were equally divided into continuous (CT) and intermittent (IT) physically trained groups. Another six participants acted as non-trained controls (CG). The trained participants practiced 6-days per week for 6 weeks. Before and after training, all participants completed an incremental exercise test to assess their MAS, and a 30- second supra-maximal exercise followed by 30 minutes of active recovery to determine the individual blood lactate recovery curve. It was found that exercise training has significantly increased MAS (p < 0.001), the lactate exchange and removal abilities as well as the lactate concentrations at the beginning of the recovery ([La]-(0)); for both CT and IT groups; this was accompanied by a significant reduction of the time to lactate-peak. Nevertheless, the improvement in MAS was significantly higher (p < 0.001) post-intermittent (15.1 % ± 2.4) than post-continuous (10.3 % ± 3.2) training. The lactate-exchange and removal abilities were also significantly higher for IT than for CT-group (P<0.05). Moreover, IT-group showed a significantly shorter half-time of the blood lactate (t-½-[La]) than CT-group (7.2 ± 0.5 min vs 7.7 ± 0.3 min, respectively) (p < 0.05). However, no significant differences were observed in peak blood lactate concentration ([La]peak), time to reach [La]peak (t-[La]peak), and [La]-(0) between the two physically-trained groups. We conclude that both continuous and intermittent training exercises were equally effective in improving t-[La]peak and [La]peak, although intermittent training was more beneficial in elevating MAS and in raising the lactate exchange (γ1) and removal (γ2) indexes. Key points Coaches and athletes need to be aware of the potentiality positive effects of exercise intensity. Improvements

  20. LACTATE KINETICS AFTER INTERMITTENT AND CONTINUOUS EXERCISE TRAINING

    Directory of Open Access Journals (Sweden)

    Adnene Gharbi

    2008-06-01

    Full Text Available The purpose of this study was to assess, the effects of continuous and intermittent exercise training on lactate kinetic parameters and maximal aerobic speed (MAS using field tests. Twenty-four male sport students were equally divided into continuous (CT and intermittent (IT physically trained groups. Another six participants acted as non-trained controls (CG. The trained participants practiced 6-days per week for 6 weeks. Before and after training, all participants completed an incremental exercise test to assess their MAS, and a 30- second supra-maximal exercise followed by 30 minutes of active recovery to determine the individual blood lactate recovery curve. It was found that exercise training has significantly increased MAS (p < 0.001, the lactate exchange and removal abilities as well as the lactate concentrations at the beginning of the recovery ([La]-(0; for both CT and IT groups; this was accompanied by a significant reduction of the time to lactate-peak. Nevertheless, the improvement in MAS was significantly higher (p < 0.001 post-intermittent (15.1 % ± 2.4 than post-continuous (10.3 % ± 3.2 training. The lactate-exchange and removal abilities were also significantly higher for IT than for CT-group (P<0.05. Moreover, IT-group showed a significantly shorter half-time of the blood lactate (t-½-[La] than CT-group (7.2 ± 0.5 min vs 7.7 ± 0.3 min, respectively (p < 0.05. However, no significant differences were observed in peak blood lactate concentration ([La]peak, time to reach [La]peak (t-[La]peak, and [La]-(0 between the two physically-trained groups. We conclude that both continuous and intermittent training exercises were equally effective in improving t-[La]peak and [La]peak, although intermittent training was more beneficial in elevating MAS and in raising the lactate exchange (γ1 and removal (γ2 indexes

  1. Accelerated anaerobic hydrolysis rates under a combination of intermittent aeration and anaerobic conditions

    DEFF Research Database (Denmark)

    Jensen, T. R.; Lastra Milone, T.; Petersen, G.

    2017-01-01

    Anaerobic hydrolysis in activated return sludge was investigated in laboratory scale experiments to find if intermittent aeration would accelerate anaerobic hydrolysis rates compared to anaerobic hydrolysis rates under strict anaerobic conditions. The intermittent reactors were set up in a 240 h...... for calculating hydrolysis rates based on soluble COD were compared. Two-way ANOVA with the Bonferroni post-test was performed in order to register any significant difference between reactors with intermittent aeration and strictly anaerobic conditions respectively. The experiment demonstrated a statistically...... significant difference in favor of the reactors with intermittent aeration showing a tendency towards accelerated anaerobic hydrolysis rates due to application of intermittent aeration. The conclusion of the work is thus that intermittent aeration applied in the activated return sludge process (ARP) can...

  2. Intermittency in relation with 1/f noise and stochastic differential equations.

    Science.gov (United States)

    Ruseckas, J; Kaulakys, B

    2013-06-01

    One of the models of intermittency is on-off intermittency, arising due to time-dependent forcing of a bifurcation parameter through a bifurcation point. For on-off intermittency, the power spectral density (PSD) of the time-dependent deviation from the invariant subspace in a low frequency region exhibits 1/√f power-law noise. Here, we investigate a mechanism of intermittency, similar to the on-off intermittency, occurring in nonlinear dynamical systems with invariant subspace. In contrast to the on-off intermittency, we consider the case where the transverse Lyapunov exponent is zero. We show that for such nonlinear dynamical systems, the power spectral density of the deviation from the invariant subspace can have 1/f(β) form in a wide range of frequencies. That is, such nonlinear systems exhibit 1/f noise. The connection with the stochastic differential equations generating 1/f(β) noise is established and analyzed, as well.

  3. The Acute Effects of Intermittent Light Exposure in the Evening on Alertness and Subsequent Sleep Architecture

    OpenAIRE

    Minqi Yang; Ning Ma; Yingying Zhu; Ying-Chu Su; Qingwei Chen; Fan-Chi Hsiao; Yanran Ji; Chien-Ming Yang; Guofu Zhou

    2018-01-01

    Exposure to bright light is typically intermittent in our daily life. However, the acute effects of intermittent light on alertness and sleep have seldom been explored. To investigate this issue, we employed within-subject design and compared the effects of three light conditions: intermittent bright light (30-min pulse of blue-enriched bright light (~1000 lux, ~6000 K) alternating with 30-min dim normal light (~5 lux, ~3600 K) three times); continuous bright light; and continuous dim light o...

  4. Intermittent fasting: A “new” historical strategy for controlling seizures?

    OpenAIRE

    Hartman, Adam L.; Rubenstein, James E.; Kossoff, Eric H.

    2012-01-01

    In antiquity, fasting was a treatment for epilepsy and a rationale for the ketogenic diet (KD). Preclinical data indicate the KD and intermittent fasting do not share identical anticonvulsant mechanisms. We implemented an intermittent fasting regimen in six children with an incomplete response to a KD. Three patients adhered to the combined intermittent fasting/KD regimen for 2 months and four had transient improvement in seizure control, albeit with some hunger-related adverse reactions.

  5. Intermittent dynamics of nonlinear resistive tearing modes at extremely high magnetic Reynolds number

    International Nuclear Information System (INIS)

    Miyoshi, Takahiro; Becchaku, Masahiro; Kusano, Kanya

    2008-01-01

    Nonlinear dynamics of the resistive tearing instability in high magnetic Reynolds number (R m ) plasmas is studied by newly developing an accurate and robust resistive magnetohydrodynamic (MHD) scheme. The results show that reconnection processes strongly depend on R m . Particularly, in a high R m case, small-scale plasmoids induced by a secondary instability are intermittently generated and ejected accompanied by fast shocks. According to the intermittent processes, the reconnection rate increases intermittently at a later nonlinear stage. (author)

  6. Intermittent fasting: A “new” historical strategy for controlling seizures?

    Science.gov (United States)

    Hartman, Adam L.; Rubenstein, James E.; Kossoff, Eric H.

    2013-01-01

    Summary In antiquity, fasting was a treatment for epilepsy and a rationale for the ketogenic diet (KD). Preclinical data indicate the KD and intermittent fasting do not share identical anticonvulsant mechanisms. We implemented an intermittent fasting regimen in six children with an incomplete response to a KD. Three patients adhered to the combined intermittent fasting/KD regimen for 2 months and four had transient improvement in seizure control, albeit with some hunger-related adverse reactions. PMID:23206889

  7. Intermittent Fasting Modulation of the Diabetic Syndrome in Streptozotocin-Injected Rats

    OpenAIRE

    Belkacemi, Louiza; Selselet-Attou, Ghalem; Hupkens, Emeline; Nguidjoe, Evrard; Louchami, Karim; Sener, Abdullah; Malaisse, Willy J.

    2012-01-01

    This study investigates the effects of intermittent overnight fasting in streptozotocin-induced diabetic rats (STZ rats). Over 30 days, groups of 5-6 control or STZ rats were allowed free food access, starved overnight, or exposed to a restricted food supply comparable to that ingested by the intermittently fasting animals. Intermittent fasting improved glucose tolerance, increased plasma insulin, and lowered Homeostatis Model Assessment index. Caloric restriction failed to cause such benefic...

  8. Circulating, cell-free DNA as a marker for exercise load in intermittent sports

    OpenAIRE

    Haller, Nils; Helmig, Susanne; Taenny, Pascal; Petry, Julian; Schmidt, Sebastian; Simon, Perikles

    2018-01-01

    Background Attempts to establish a biomarker reflecting individual player load in intermittent sports such as football have failed so far. Increases in circulating DNA (cfDNA) have been demonstrated in various endurance sports settings. While it has been proposed that cfDNA could be a suitable marker for player load in intermittent sports, the effects on cfDNA of repeated sprinting as an essential feature in intermittent sports are unknown. For the first time, we assessed both alterations of ...

  9. Intermittency in MHD turbulence and coronal nanoflares modelling

    Directory of Open Access Journals (Sweden)

    P. Veltri

    2005-01-01

    Full Text Available High resolution numerical simulations, solar wind data analysis, and measurements at the edges of laboratory plasma devices have allowed for a huge progress in our understanding of MHD turbulence. The high resolution of solar wind measurements has allowed to characterize the intermittency observed at small scales. We are now able to set up a consistent and convincing view of the main properties of MHD turbulence, which in turn constitutes an extremely efficient tool in understanding the behaviour of turbulent plasmas, like those in solar corona, where in situ observations are not available. Using this knowledge a model to describe injection, due to foot-point motions, storage and dissipation of MHD turbulence in coronal loops, is built where we assume strong longitudinal magnetic field, low beta and high aspect ratio, which allows us to use the set of reduced MHD equations (RMHD. The model is based on a shell technique in the wave vector space orthogonal to the strong magnetic field, while the dependence on the longitudinal coordinate is preserved. Numerical simulations show that injected energy is efficiently stored in the loop where a significant level of magnetic and velocity fluctuations is obtained. Nonlinear interactions give rise to an energy cascade towards smaller scales where energy is dissipated in an intermittent fashion. Due to the strong longitudinal magnetic field, dissipative structures propagate along the loop, with the typical speed of the Alfvén waves. The statistical analysis on the intermittent dissipative events compares well with all observed properties of nanoflare emission statistics. Moreover the recent observations of non thermal velocity measurements during flare occurrence are well described by the numerical results of the simulation model. All these results naturally emerge from the model dynamical evolution without any need of an ad-hoc hypothesis.

  10. Supplemental intermittent-day heat training and the lactate threshold.

    Science.gov (United States)

    Gollan, Stuart; Chalmers, Samuel; Alderton, Stephen; Norton, Kevin

    2017-04-01

    Heat acclimation over consecutive days has been shown to improve aerobic-based performance. Recently, it has been suggested that heat training can improve performance in a temperate environment. However, due to the multifactorial training demands of athletes, consecutive-day heat training may not be suitable. The current study aimed to investigate the effect of brief (8×30min) intermittent (every 3-4 days) supplemental heat training on the second lactate threshold point (LT 2 ) in temperate and hot conditions. 21 participants undertook eight intermittent-day mixed-intensity treadmill exercise training sessions in hot (30°C; 50% relative humidity [RH]) or temperate (18°C; 30% RH) conditions. A pre- and post-incremental exercise test occurred in temperate (18°C; 30% RH) and hot conditions (30°C; 50% RH) to determine the change in LT 2 . The heat training protocol did not improve LT 2 in temperate (Effect Size [ES]±90 confidence interval=0.10±0.16) or hot (ES=0.26±0.26) conditions. The primary finding was that although the intervention group had a change greater than the SWC, no statistically significant improvements were observed following an intermittent eight day supplemental heat training protocol comparable to a control group training only in temperate conditions. This is likely due to the brief length of each heat training session and/or the long duration between each heat exposure. Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. Effects of intermittent fasting on glucose and lipid metabolism.

    Science.gov (United States)

    Antoni, Rona; Johnston, Kelly L; Collins, Adam L; Robertson, M Denise

    2017-08-01

    Two intermittent fasting variants, intermittent energy restriction (IER) and time-restricted feeding (TRF), have received considerable interest as strategies for weight-management and/or improving metabolic health. With these strategies, the pattern of energy restriction and/or timing of food intake are altered so that individuals undergo frequently repeated periods of fasting. This review provides a commentary on the rodent and human literature, specifically focusing on the effects of IER and TRF on glucose and lipid metabolism. For IER, there is a growing evidence demonstrating its benefits on glucose and lipid homeostasis in the short-to-medium term; however, more long-term safety studies are required. Whilst the metabolic benefits of TRF appear quite profound in rodents, findings from the few human studies have been mixed. There is some suggestion that the metabolic changes elicited by these approaches can occur in the absence of energy restriction, and in the context of IER, may be distinct from those observed following similar weight-loss achieved via modest continuous energy restriction. Mechanistically, the frequently repeated prolonged fasting intervals may favour preferential reduction of ectopic fat, beneficially modulate aspects of adipose tissue physiology/morphology, and may also impinge on circadian clock regulation. However, mechanistic evidence is largely limited to findings from rodent studies, thus necessitating focused human studies, which also incorporate more dynamic assessments of glucose and lipid metabolism. Ultimately, much remains to be learned about intermittent fasting (in its various forms); however, the findings to date serve to highlight promising avenues for future research.

  12. Dynamic droop scheme considering effect of intermittent renewable energy source

    DEFF Research Database (Denmark)

    Wang, Yanbo; Chen, Zhe; Deng, Fujin

    2016-01-01

    This paper presents a dynamic droop control scheme for islanded microgrids dominated by intermittent renewable energy sources, which is able to perform desirable power sharing in the presence of renewable energy source fluctuation. First, allowable maximum power points of wind generator and PV...... flexibility and effectiveness in the presence of the renewable energy sources fluctuation....... controller of each DG unit is activated through local logic variable inferred by wind speed and solar insolation information. Simulation results are given for validating the droop control scheme. The proposed dynamic droop scheme preserves the advantage of conventional droop control method, and provides...

  13. Turbulence and intermittent transport at the boundary of magnetized plasmas

    DEFF Research Database (Denmark)

    Garcia, O.E.; Naulin, V.; Nielsen, A.H.

    2005-01-01

    fluctuation wave forms and transport statistics are also in a good agreement with those derived from the experiments. Associated with the turbulence bursts are relaxation oscillations in the particle and heat confinements as well as in the kinetic energy of the sheared poloidal flows. The formation of blob...... a forcing region with spatially localized sources of particles and heat outside which losses due to the motion along open magnetic-field lines dominate, corresponding to the edge region and the scrape-off layer, respectively. Turbulent states reveal intermittent eruptions of hot plasma from the edge region...

  14. Fluctuation relations with intermittent non-Gaussian variables.

    Science.gov (United States)

    Budini, Adrián A

    2011-12-01

    Nonequilibrium stationary fluctuations may exhibit a special symmetry called fluctuation relations (FRs). Here, we show that this property is always satisfied by the subtraction of two random and independent variables related by a thermodynamiclike change of measure. Taking one of them as a modulated Poisson process, it is demonstrated that intermittence and FRs are compatible properties that may coexist naturally. Strong non-Gaussian features characterize the probability distribution and its generating function. Their associated large deviation functions develop a "kink" at the origin and a plateau regime respectively. Application of this model in different stationary nonequilibrium situations is discussed.

  15. Intermittent sizing on carbon fiber for composite application

    Energy Technology Data Exchange (ETDEWEB)

    Norris, Jr, Robert E. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Paulauskas, Felix L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Ozcan, Soydan [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Xiong, Fue [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Grappe, Hippolyte A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-08-01

    Intermittent sizing is a technique designed to improve the bonding of carbon fiber to a resin when manufacturing composite parts. The purpose of this technique is to improve Sheet Molding Composites (SMC) made of non-continuous carbon fibers while using regular material. At the end of the project, tests showed that improved mechanical properties have been achieved using this technique compared to conventional process. Mechanical properties have been improved by 110% for the peak tensile stress and by 60% for the modulus at the laboratory scale. In this project, Continental Structural Plastics and ORNL have worked to demonstrate the scalability and viability of commercialization of this technique.

  16. Validity, Reliability, and Sensitivity of a Volleyball Intermittent Endurance Test.

    Science.gov (United States)

    Rodríguez-Marroyo, Jose A; Medina-Carrillo, Javier; García-López, Juan; Morante, Juan C; Villa, José G; Foster, Carl

    2017-03-01

    To analyze the concurrent and construct validity of a volleyball intermittent endurance test (VIET). The VIET's test-retest reliability and sensitivity to assess seasonal changes was also studied. During the preseason, 71 volleyball players of different competitive levels took part in this study. All performed the VIET and a graded treadmill test with gas-exchange measurement (GXT). Thirty-one of the players performed an additional VIET to analyze the test-retest reliability. To test the VIET's sensitivity, 28 players repeated the VIET and GXT at the end of their season. Significant (P volleyball players.

  17. Multi-point observations of intermittency in the cusp regions

    Directory of Open Access Journals (Sweden)

    M. M. Echim

    2007-08-01

    Full Text Available In this paper we investigate the statistical properties of magnetic field fluctuations measured by the four Cluster spacecraft in the cusp and close to the interface with the magnetospheric lobes, magnetopause and magnetosheath. At lower altitudes along the outbound orbit of 26 February 2001, the magnetic field fluctuations recorded by all four spacecraft are random and their Probability Distribution Functions (PDFs are Gaussian at all scales. The flatness parameter, F – related to the kurtosis of the time series, is equal to 3. At higher altitudes, in the cusp and its vicinity, closer to the interface with the magnetopause and magnetosheath, the PDFs from all Cluster satellites are non-Gaussian and show a clear intermittent behavior at scales smaller than τG≈ 61 s (or 170 km. The flatness parameter increases to values greater than 3 for scales smaller than τG. A Haar wavelet transform enables the identification of the "events" that produce sudden variations of the magnetic field and of the scales that have most of the power. The LIM parameter (i.e. normalized wavelet power indicates that events for scales below 65 s are non-uniformly distributed throughout the cusp passage. PDFs, flatness and wavelet analysis show that at coarse-grained scales larger than τG the intermittency is absent in the cusp. Fluctuations of the magnetic energy observed during the same orbit in the magnetosheath show PDFs that tend toward a Gaussian at scales smaller than τG found in the cusp. The flatness analysis confirms the decreasing of τG from cusp to magnetosheath. Our analysis reveals the turbulent cusp as a transition region from a non-intermittent turbulent state inside the magnetosphere to an intermittent turbulent state in the magnetosheath that has statistical properties resembling the solar wind turbulence. The observed turbulent fluctuations in the cusp suggests a phenomenon of nonlinear

  18. Atomistic Model of Fluorescence Intermittency of Colloidal Quantum Dots

    KAUST Repository

    Voznyy, O.

    2014-04-16

    Optoelectronic applications of colloidal quantum dots demand a high emission efficiency, stability in time, and narrow spectral bandwidth. Electronic trap states interfere with the above properties but understanding of their origin remains lacking, inhibiting the development of robust passivation techniques. Here we show that surface vacancies improve the fluorescence yield compared to vacancy-free surfaces, while dynamic vacancy aggregation can temporarily turn fluorescence off. We find that infilling with foreign cations can stabilize the vacancies, inhibiting intermittency and improving quantum yield, providing an explanation of recent experimental observations. © 2014 American Physical Society.

  19. Dispersion from safety valves and other momentum emission sources: Intermittent

    Science.gov (United States)

    De Faveri, D. M.; Hanzevack, E. L.; Delaney, B. T.

    A previous paper confirmed a method for calculating critical ground level concentrations from a continuous momentum plume emission source. However, use of the correlations developed for steady state releases results in inaccurate ground level concentration predictions for short term release situations. Therefore, additional tracer-gas experiments were performed in order to measure critical ground level concentrations from intermittent safety valve vent releases. These experimental results led to the development of a calculation procedure for estimating critical ground level concentrations resulting from releases for various lengths of time (up to 15 min) and for estimating critical ground level concentrations for averaging times longer than the release time.

  20. Fluvial Volumes, Timescales, and Intermittency in Milna Crater, Mars

    Science.gov (United States)

    Buhler, P.; Fassett, C. I.; Head, J. W.; Lamb, M. P.

    2017-01-01

    Ancient lake deposits and valley networks on Mars provide strong evidence that its surface was once modified by liquid water, but the extent of that modification is still debated. Ancient lacustrine deposits in Milna Crater provide insight into the timescale and fluid volume required to construct fluvially derived sedimentary deposits near the Noachian-Hesperian boundary. Placing the lacustrine deposits their regional context in Paraná Valles provides a quantitative measurement of the intermittency of large, water-mediated sediment transport events in that region.

  1. Intermittent contact atomic force microscopy in electrochemical environment

    Energy Technology Data Exchange (ETDEWEB)

    Haering, P.; Koetz, R. [Paul Scherrer Inst. (PSI), Villigen (Switzerland); Siegenthaler, H. [Bern Univ., Bern (Switzerland)

    1997-06-01

    In situ measurements with Atomic Force Microscopy may cause surface modifications due to the tip-surface interactions. As an alternative and less destructive method, Intermittent Contact Atomic Force Microscopy (ICAFM) has been tested in an electrolytic environment. In the ICAFM mode the tip is not constantly in contact with the surface under investigation but is tapping onto the surface with a certain frequency. A commercial Park Scientific Instruments Microscopy has been modified to enable in situ experiment with ICAFM. It was possible to image iridium oxide films with ICAFM in the electrolytic environment without any noticeable surface modifications. (author) 3 figs., 4 refs.

  2. Google matrix and Ulam networks of intermittency maps.

    Science.gov (United States)

    Ermann, L; Shepelyansky, D L

    2010-03-01

    We study the properties of the Google matrix of an Ulam network generated by intermittency maps. This network is created by the Ulam method which gives a matrix approximant for the Perron-Frobenius operator of dynamical map. The spectral properties of eigenvalues and eigenvectors of this matrix are analyzed. We show that the PageRank of the system is characterized by a power law decay with the exponent beta dependent on map parameters and the Google damping factor alpha . Under certain conditions the PageRank is completely delocalized so that the Google search in such a situation becomes inefficient.

  3. Intermittency in hadronic decays of the Z sup 0

    Energy Technology Data Exchange (ETDEWEB)

    Akrawy, M.Z.; Alexander, G.; Allison, J.; Allport, P.P.; Anderson, K.J.; Armitage, J.C.; Ashton, P.; Astbury, A.; Axen, D.; Azuelos, G.; Baines, J.T.M.; Ball, A.H.; Banks, J.; Barker, G.J.; Barlow, R.J.; Batley, J.R.; Beaudoin, G.; Beck, A.; Becker, J.; Behnke, T.; Bell, K.W.; Bella, G.; Bethke, S.; Biebel, O.; Binder, U.; Bloodworth, I.J.; Bock, P.; Bougerolle, S.; Brabson, B.B.; Breuker, H.; Brown, R.M.; Brun, R.; Buijs, A.; Burckhart, H.J.; Capiluppi, P.; Carnegie, R.K.; Carter, A.A.; Carter, J.R.; Chang, C.Y.; Charlton, D.G.; Chrin, J.T.M.; Clarke, P.E.L.; Cohen, I.; Collins, W.J.; Conboy, J.E.; Cooper, M.; Couch, M.; Coupland, M.; Cuffiani, M.; Dado, S.; Dallavalle, G.M.; De Jong, S.; Debu, P.; Deninno, M.M.; Dieckmann, A.; Dittmar, M.; Dixit, M.S.; Duchovni, E.; Duerdoth, I.P.; Dumas, D.J.P.; Elcombe, P.A.; Estabrooks, P.G.; Etzion, E.; Fabbri, F.; Farthouat, P.; Fincke-Keeler, M.; Fischer, H.M.; Fong, D.G.; Fukunaga, C.; Gaidot, A.; Ganel, O.; Gary, J.W.; Gascon, J.; Geddes, N.I; OPAL Collaboration

    1991-06-20

    A factorial moment analysis has been performed on the differential multiplicity distributions of hadronic final states of the Z{sup 0} recorded with the OPAL detector at LEP. The moments of the one-dimensional rapidity and the two-dimensional rapidity versus azimuthal angle distributions are found to exhibit 'intermittent' behaviour attributable to the jet structure of the events. The moments are reproduced by both parton shower and matrix element QCD based hadronisation models. No evidence for fluctuations beyond those attributable to jet structure is observed. (orig.).

  4. Differential diagnosis of acute abdominal pain – acute intermittent porphyria

    Directory of Open Access Journals (Sweden)

    Mislav Klobučić

    2011-08-01

    Full Text Available Acute intermittent porphyria (AIP is a rare autosomal dominant disorder of heme biosynthesis in liver due to deficiency of porphobilinogen deaminase enzyme. Clinically, AIP is dominatedby a colicky type pain, which does not subside after taking usual analgesics. Additional frequent symptoms are vomiting, hypertension, peripheral neuropathy, seizures, depression, delirium and coma. This paper reported a case of a twenty-fi- ve-year-old female patient, who had undergone a period of six days between the first presentationto the medical department and the diagnosis confirmation. It has accentuated possible mistakes in symptomatic therapy administration as well as dangers of a delayed diagnosis.

  5. Degrees-of-Freedom of the MIMO Three-Way Channel with Node-Intermittency

    KAUST Repository

    Neu, Joachim

    2017-08-28

    The characterization of fundamental performance bounds of many-to-many communication systems in which participating nodes are active in an intermittent way is one of the major challenges in communication theory. In order to address this issue, we introduce the multiple-input multiple-output (MIMO) three-way channel (3WC) with an intermittent node and study its degrees-of-freedom (DoF) region and sum-DoF. We devise a non-adaptive encoding scheme based on zero-forcing, interference alignment and erasure coding, and show its DoF region (and thus sum-DoF) optimality for non-intermittent 3WCs and its sum-DoF optimality for (node-)intermittent 3WCs. However, we show by example that in general some DoF tuples in the intermittent 3WC can only be achieved by adaptive schemes, such as multi-hop or decode-forward relaying. This shows that non-adaptive encoding is sufficient for the non-intermittent 3WC and for the sum-DoF of intermittent 3WCs, but adaptive encoding is necessary for the DoF region of intermittent 3WCs. Our work contributes to a better understanding of the fundamental limits of multi-way communication systems with intermittency and the impact of adaptation therein.

  6. Thymic Selection of T Cells as Diffusion with Intermittent Traps

    Science.gov (United States)

    Košmrlj, Andrej

    2011-04-01

    T cells orchestrate adaptive immune responses by recognizing short peptides derived from pathogens, and by distinguishing them from self-peptides. To ensure the latter, immature T cells (thymocytes) diffuse within the thymus gland, where they encounter an ensemble of self-peptides presented on (immobile) antigen presenting cells. Potentially autoimmune T cells are eliminated if the thymocyte binds sufficiently strongly with any such antigen presenting cell. We model thymic selection of T cells as a random walker diffusing in a field of immobile traps that intermittently turn "on" and "off". The escape probability of potentially autoimmune T cells is equivalent to the survival probability of such a random walker. In this paper we describe the survival probability of a random walker on a d-dimensional cubic lattice with randomly placed immobile intermittent traps, and relate it to the result of a well-studied problem where traps are always "on". Additionally, when switching between the trap states is slow, we find a peculiar caging effect for the survival probability.

  7. Asymptomatic carotid stenosis in patients with intermittent claudication: epidemiological study.

    Science.gov (United States)

    Ramos, M J; González-Fajardo, J A; Vaquero-Puerta, C; Vallina-Victorero, M; Vicente-Santiago, M; Vaquero-Lorenzo, F; Alvarez-Salgado, A; Alvarez-Fernandez, J

    2011-12-01

    The aim of this paper was to determine the prevalence of extracraneal carotid artery disease in patients with intermittent claudication, to describe classic cardiovascular risk factors in those with hemodynamically significant stenosis and to try to define subgroups at high risk, improving therefore the performance of non invasive testing. A prospective descriptive study was conducted, with 146 patients reporting an intermittent claudication of the lower limbs and without a previous cerebrovascular event or carotid surgery. An ultrasonography examination was done. Risk factors were registed (smoking, dislipemia, arterial hypertension, diabetes mellitus), also ischemic cardiopathy and myocardial revascularization procedures. Univariate and multivariate analysis was made to define the variables associated with hemodynamically significant stenosis. Prevalence of hemodynamically significant stenosis was 23.2%. Smoking, dislipemia, arterial hypertension and diabetes mellitus were not significantly associated with carotid stenosis; 24.2% of patients affected of ischemic cardiopathy present a severe stenosis, and myocardial revascularization was a risk factor for carotid stenosis. Patients with claudication and ischemic miocardiopathy, especially when myocardial revascularization is needed, must be explored with carotid ultrasonography. In this patients, probably of hemodynamically significant carotid stenosis that requires treatment is more frequent.

  8. Intermittent structures at ion scales in the turbulent solar wind

    Science.gov (United States)

    Perrone, Denise; Alexandrova, Olga; Lion, Sonny; Roberts, Owen W.; Maksimovic, Milan; Escoubet, Philippe C.; Zouganelis, Yannis

    2017-04-01

    Understanding the physical mechanisms of dissipation, and the related heating, in turbulent collisionless plasmas (such as the solar wind) represents nowadays one of the key issues of plasma physics. Although the complex behavior of the solar wind has been matter of investigation of many years, some of the primary problems still remain a puzzle for the scientific community. Here, we study coherent structures responsible for solar wind intermittency around ion characteristic scales. We find that, in fast solar wind, intermittency is due to current sheets and Alfvén vortex-like structures. In slow solar wind, we observe as well compressive structures like magnetic solitons, holes and shocks. By using high-time resolution magnetic field data of multi-point measurements of Cluster spacecraft, we characterize the observed coherent structures in terms of topology and propagation speed. We show that all structures, both in fast and slow solar wind, are characterized by a strong wave-vector anisotropy in the perpendicular direction with respect to the local magnetic field and typical scales around ion characteristic scales. Moreover, some of them propagate in the plasma rest frame. Moreover, a further analysis on the ion velocity distribution shows a high variability; in particular, close to coherent structures the proton distribution function appears strongly deformed and far from the thermodynamic equilibrium. We discuss possible interpretation of the observed structures and their role in the heating process of the plasma.

  9. Biological Nutrient Removal in an Intermittently Aerated Bioreactor

    Directory of Open Access Journals (Sweden)

    J. Derco

    2017-07-01

    Full Text Available The extension of biological processes from carbonaceous impurities removal to nitrogen and phosphorus removal had an impact on the biological system configuration. The system must be well designed, optimized, and operated at its optimum in order to meet the ever more stringent effluent standards. An intermittently aerated completely mixed lab-scale activated sludge bioreactor (IACMB has been used for modelling biological processes of nutrients removal. Concerning the nitrogen removal, the operating cycles 15–30 (15 minutes of aeration, 30 minutes of only mixing without aeration and 30–30 were tested. For the experiments with luxury uptake processes, the operating cycles 15–45, 15–90, 30–60 and 15–75 were used. The cycle 15–75 was the most satisfactory with convenient lengths of aerobic, anoxic, and anaerobic period, high efficiency of the nitrification and denitrification processes, and significant decrease in phosphorus concentration. The results have shown that the intermittently aerated bioreactors are suitable for nitrogen removal as well as luxury uptake of phosphorus. The main advantage is high flexibility in maintenance and control of biochemical environments in the bioreactor.

  10. Tracking Intermittently Speaking Multiple Speakers Using a Particle Filter

    Directory of Open Access Journals (Sweden)

    Angela Quinlan

    2009-01-01

    Full Text Available The problem of tracking multiple intermittently speaking speakers is difficult as some distinct problems must be addressed. The number of active speakers must be estimated, these active speakers must be identified, and the locations of all speakers including inactive speakers must be tracked. In this paper we propose a method for tracking intermittently speaking multiple speakers using a particle filter. In the proposed algorithm the number of active speakers is firstly estimated based on the Exponential Fitting Test (EFT, a source number estimation technique which we have proposed. The locations of the speakers are then tracked using a particle filtering framework within which the decomposed likelihood is used in order to decouple the observed audio signal and associate each element of the decomposed signal with an active speaker. The tracking accuracy is then further improved by the inclusion of a silence region detection step and estimation of the noise-only covariance matrix. The method was evaluated using live recordings of 3 speakers and the results show that the method produces highly accurate tracking results.

  11. Positive effects of intermittent fasting in ischemic stroke.

    Science.gov (United States)

    Fann, David Yang-Wei; Ng, Gavin Yong Quan; Poh, Luting; Arumugam, Thiruma V

    2017-03-01

    Intermittent fasting (IF) is a dietary protocol where energy restriction is induced by alternate periods of ad libitum feeding and fasting. Prophylactic intermittent fasting has been shown to extend lifespan and attenuate the progress and severity of age-related diseases such as cardiovascular (e.g. stroke and myocardial infarction), neurodegenerative (e.g. Alzheimer's disease and Parkinson's disease) and cancerous diseases in animal models. Stroke is the second leading cause of death, and lifestyle risk factors such as obesity and physical inactivity have been associated with elevated risks of stroke in humans. Recent studies have shown that prophylactic IF may mitigate tissue damage and neurological deficit following ischemic stroke by a mechanism(s) involving suppression of excitotoxicity, oxidative stress, inflammation and cell death pathways in animal stroke models. This review summarizes data supporting the potential hormesis mechanisms of prophylactic IF in animal models, and with a focus on findings from animal studies of prophylactic IF in stroke in our laboratory. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. Effects of Intermittent Traction in Patients With Cervical Osteoarthritis

    Directory of Open Access Journals (Sweden)

    Mohammad Akbari

    2010-05-01

    Full Text Available Background:Osteoarthritis(OA is the most common joint disease occuring after middle age.Because of the high mobility of the neck, OA is common in the cervical spine. The purpose of this study was to determine and compare the effects of intermittent traction on patients with mild and moderate cervical OA. Therefore, 32 patients with cervical OA were recruited.Methods:Aclinical trial study was designed for patients with cervical OA that were randomly assigned in two equal groups.Control group received a routine physical therapy protocol which included moist heat, transcutaneous electrical nerve stimulation (TENS, and an exercise for neck and shoulder girdle. Experimental group received a routine physical therapy protocol plus intermittent traction (IT.Results: Pain and mobility improved in both groups.There was significant difference in interaction of the improvement of cervical pain between the two groups,the rate of pain reduction; sleep ease, medicine taking and range of motion (ROM improvement in the experimental group were higher than that of the control group.Conclusion: The results justify the efficacy of IT, therefore it can be concluded that the IT is an effective modality for patients with mild and moderate cervical OA.  

  13. Intermittency in the Helimak, a simple magnetic torus

    Science.gov (United States)

    Taylor, E. I.; Rowan, W. L.; Gentle, K. W.; Horton, W.; Bernard, T.

    2017-10-01

    Irregularly-spaced, large-amplitude bursts are observed in the Helimak plasma turbulence with sufficient definition to investigate their physical basis and possibly improve understanding of the induced particle transport. The Helimak is an experimental realization of a sheared cylindrical slab that generates and heats a plasma with microwaves and confines it in a helical magnetic field. Although it is MHD stable, the plasma is always in a nonlinearly saturated state of microturbulence. The intermittency in this turbulence manifests itself in highly skewed PDFs of the normalized electron density. Cross-conditional averaging exposes large amplitude structures propagating down the density gradient at a few hundred meters per second. Introduction of a radial electric field via bias plates appears to suppress these intermittent transport events (ITEs) for Er pointing down the density gradient. In addition, the cross-conditionally averaged waveforms are relatively unchanged as connection length is varied. Within certain regimes, our measurements are consistent with the predictions of a stochastic model that represents the plasma fluctuations as a random sequence of burst events. Furthermore, we attempt to gain insight into the physical origin of these ITEs by searching for similar statistical behavior in fluid and gyrokinetic simulations. This material is based upon work supported by the U.S. Department of Energy Office of Science, Office of Fusion Energy Sciences under Award Number DE-FG02- 04ER5476.

  14. Antral hyperplastic polyp causing intermittent gastric outlet obstruction: Case report

    Directory of Open Access Journals (Sweden)

    Kurtkaya-Yapicier Ozlem

    2003-06-01

    Full Text Available Abstract Background Hyperplastic polyps are the most common polypoid lesions of the stomach. Rarely, they cause gastric outlet obstruction by prolapsing through the pyloric channel, when they arise in the prepyloric antrum. Case presentation A 62-year-old woman presented with intermittent nausea and vomiting of 4 months duration. Upper gastrointestinal endoscopy revealed a 30 mm prepyloric sessile polyp causing intermittent gastric outlet obstruction. Following submucosal injection of diluted adrenaline solution, the polyp was removed with a snare. Multiple biopsies were taken from the greater curvature of the antrum and the corpus. Rapid urease test for Helicobacter pylori yielded a negative result. Histopathologic examination showed a hyperplastic polyp without any evidence of malignancy. Biopsies of the antrum and the corpus revealed gastritis with neither atrophic changes nor Helicobacter pylori infection. Follow-up endoscopy after a 12-week course of proton pomp inhibitor therapy showed a complete healing without any remnant tissue at the polypectomy site. The patient has been symptom-free during 8 months of follow-up. Conclusions Symptomatic gastric polyps should be removed preferentially when they are detected at the initial diagnostic endoscopy. Polypectomy not only provides tissue to determine the exact histopathologic type of the polyp, but also achieves radical treatment.

  15. Intermittent exotropia surgery: results in different age groups.

    Science.gov (United States)

    Issaho, Dayane Cristine; Wang, Serena Xiaohong; Weakley, David Robert

    2017-01-01

    To report the outcomes in patients undergoing surgical correction of intermittent exotropia and to compare the age at surgery to motor and sensory success. This was a retrospective cohort study. The results of patients with intermittent exotropia treated with surgery over a 4-year period were reviewed. Patients were divided into two groups based on age at first surgery (groups. One hundred thirty-six patients were evaluated, with 67 and 51 patients undergoing surgery before and after the age of 4 years, respectively. The mean age at surgery was 6.8 ± 2.6 years. The reoperation rate for the patients who underwent surgery before 4 years of age was 48% versus 42% for the ones who underwent surgery after this age (p=0.93). Postoperative stereopsis showed an inverse linear association with age at surgery (page, and may even present better motor results than older patients. Postoperative stereoacuity in younger children revealed to be worse than in older children; however, this result is unlikely to be due to inadequate age for surgery, but rather, immaturity for performing the stereopsis test.

  16. Intermittent bradyarrhythmia in a Hispaniolan Amazon parrot (Amazona ventralis).

    Science.gov (United States)

    Rembert, Melanie S; Smith, Julie A; Strickland, Keith N; Tully, Thomas N

    2008-03-01

    A clinically normal 2-year-old Hispaniolan Amazon parrot (Amazona ventralis) was found to have periodic second-degree atrioventricular (AV) block with variable nodal conductions while anesthetized with isoflurane during a thermal-support research project. Arrhythmias were observed on 5 successive weekly electrocardiograms. A complete cardiac evaluation, including a diagnostic electrocardiogram, revealed intermittent bradyarrhythmias ranging from a 2:1 to a 7:1 second-degree AV block, with concurrent hypotensive episodes during the nodal blocks. Results of a complete blood cell count, plasma biochemical profile, blood gas analysis, and atropine-response test, as well as radiography and auscultation, revealed no obvious cause for the arrhythmias. Echocardiography demonstrated cardiac wall thickness, chamber size, and systolic function similar to other psittacine birds. On return to the colony, the parrot continued to be outwardly asymptomatic despite the dramatic conduction disturbances. Although cardiac arrhythmias, including second-degree AV block, have been widely reported in birds, the wide variation of nodal conductions, the intermittent nature, and an arrhythmia with a 7:1 second-degree AV block that spontaneously reverts to normal as seen in this case have not been well documented in parrots.

  17. Assessment of intermittent trace element pollution by moss bags

    Energy Technology Data Exchange (ETDEWEB)

    Cesa, M. [Dipartimento di Biologia, Universita di Trieste, Via Giorgieri 10, I-34127 Trieste (Italy)]. E-mail: mcesa@units.it; Bizzotto, A. [ARPAV Dipartimento di Vicenza, Servizio Territoriale di Bassano del Grappa, Via Cereria 15, I-36061 Bassano del Grappa (VI) (Italy); Ferraro, C. [ARPAV Dipartimento di Vicenza, Servizio Territoriale di Bassano del Grappa, Via Cereria 15, I-36061 Bassano del Grappa (VI) (Italy); Fumagalli, F. [Dipartimento di Biologia, Universita di Trieste, Via Giorgieri 10, I-34127 Trieste (Italy); Nimis, P.L. [Dipartimento di Biologia, Universita di Trieste, Via Giorgieri 10, I-34127 Trieste (Italy)

    2006-12-15

    Moss bags of the aquatic bryophyte Rhynchostegium riparioides (Hedw.) C. Jens. were transplanted into an irrigation ditch in the Province of Vicenza (NE Italy), affected by intermittent trace element contamination due to galvanics. The study aimed at: (a) testing the ability of mosses to detect different patterns of pollution (b) providing information about intensity and temporal extension of pollution events, and (c) localising the main sources. Moss bags were collected after 20, 34, 48 and 62 days of exposure. The concentrations of As, Cd, Cr, Cu, Hg, Mn, Ni, Pb and Zn in the desiccated apical shoots of mosses were determined by atomic absorption spectrophotometry. The mean concentrations measured in non-contaminated stations of a previous work were adopted as background values, to calculate the contamination factor (CF). Transplants were able to: (a) detect spatial patterns of bioaccumulation (b) reveal chronic contamination by Pb and Cu, intermittent contamination by Cr, Zn, and Ni, and a release of Cd by moss bags, and (c) localise the main emission sources. - Transplanted bryophytes are able to detect accidental trace element pollution in freshwaters of industrial areas.

  18. Intermittent Smoothing Approaches for Wind Power Output: A Review

    Directory of Open Access Journals (Sweden)

    Muhammad Jabir

    2017-10-01

    Full Text Available Wind energy is one of the most common types of renewable energy resource. Due to its sustainability and environmental benefits, it is an emerging source for electric power generation. Rapid and random changes of wind speed makes it an irregular and inconsistent power source when connected to the grid, causing different technical problems in protection, power quality and generation dispatch control. Due to these problems, effective intermittent smoothing approaches for wind power output are crucially needed to minimize such problems. This paper reviews various intermittent smoothing approaches used in smoothing the output power fluctuations caused by wind energy. Problems associated with the inclusion of wind energy resources to grid are also briefly reviewed. From this review, it has been found that battery energy storage system is the most suitable and effective smoothing approach, provided that an effective control strategy is available for optimal utilization of battery energy system. This paper further demonstrates different control strategies built for battery energy storage system to obtain the smooth output wind power.

  19. Removal of Pharmaceuticals from Wastewater by Intermittent Electrocoagulation

    Directory of Open Access Journals (Sweden)

    Benny Marie B. Ensano

    2017-01-01

    Full Text Available The continuous release of emerging contaminants (ECs in the aquatic environment, as a result of the inadequate removal by conventional treatment methods, has prompted research to explore viable solutions to this rising global problem. One promising alternative is the use of electrochemical processes since they represent a simple and highly efficient technology with less footprint. In this paper, the feasibility of treating ECs (i.e., pharmaceuticals using an intermittent electrocoagulation process, a known electrochemical technology, has been investigated. Diclofenac (DCF, carbamazepine (CBZ and amoxicillin (AMX were chosen as being representative of highly consumed drugs that are frequently detected in our water resources and were added in synthetic municipal wastewater. The removal efficiencies of both individual and combined pharmaceuticals were determined under different experimental conditions: hydraulic retention time (HRT (6, 19 and 38 h, initial concentration (0.01, 4 and 10 mg/L and intermittent application (5 min ON/20 min OFF of current density (0.5, 1.15 and 1.8 mA/cm2. Results have shown that these parameters have significant effects on pharmaceutical degradation. Maximum removals (DCF = 90%, CBZ = 70% and AMX = 77% were obtained at a current density of 0.5 mA/cm2, an initial concentration of 10 mg/L and HRT of 38 h.

  20. Lagrangian Statistics and Intermittency in Gulf of Mexico.

    Science.gov (United States)

    Lin, Liru; Zhuang, Wei; Huang, Yongxiang

    2017-12-12

    Due to the nonlinear interaction between different flow patterns, for instance, ocean current, meso-scale eddies, waves, etc, the movement of ocean is extremely complex, where a multiscale statistics is then relevant. In this work, a high time-resolution velocity with a time step 15 minutes obtained by the Lagrangian drifter deployed in the Gulf of Mexico (GoM) from July 2012 to October 2012 is considered. The measured Lagrangian velocity correlation function shows a strong daily cycle due to the diurnal tidal cycle. The estimated Fourier power spectrum E(f) implies a dual-power-law behavior which is separated by the daily cycle. The corresponding scaling exponents are close to -1.75 and -2.75 respectively for the time scale larger (resp. 0.1 ≤ f ≤ 0.4 day -1 ) and smaller (resp. 2 ≤ f ≤ 8 day -1 ) than 1 day. A Hilbert-based approach is then applied to this data set to identify the possible multifractal property of the cascade process. The results show an intermittent dynamics for the time scale larger than 1 day, while a less intermittent dynamics for the time scale smaller than 1 day. It is speculated that the energy is partially injected via the diurnal tidal movement and then transferred to larger and small scales through a complex cascade process, which needs more studies in the near future.

  1. Vínculo materno-fetal: implicaciones en el desarrollo psicológico y propuesta de intervención en atención temprana (Maternal-foetal bonding: implications for psychological development and proposal for early intervention

    Directory of Open Access Journals (Sweden)

    Claudia Patricia Roncallo

    2015-09-01

    Full Text Available Health research has identified maternal-foetal bonding as a significant antecedent of post-natal bonding between mother and baby. Maternal-foetal bonding is associated with the emotional and cognitive aspects that allow the foetus to be recreated as another human being. This bond is expressed in health practices aimed at the protection and welfare of the foetus. It has been observed that the psychological state of the mother affects the foetus at the neurobehavioral level and influences the appearance of developmental disorders that also manifest in the post-natal period, thereby significantly affecting the mother-baby relationship. Thus, early intervention practices could be extended to the prenatal period as a prevention strategy to favourably impact the health of the child and mother. To address this issue, we present an interdisciplinary intervention model, which focuses on maternal-foetal bonding as a protective factor for bonding during the postnatal period, and as an enhancer of positive parenting practices that promote healthy psychological development.

  2. Associação entre a antropometria e a leptina circulante nos compartimentos materno, fetal e placentário, na gravidez normal Association between anthropometry and circulating leptin in maternal, fetal and placental compartments, in healthy pregnancy

    Directory of Open Access Journals (Sweden)

    Flávia Cipriano Castro

    2004-10-01

    Full Text Available OBJETIVO: avaliar a importância da leptina materna e fetal circulantes na gestação saudável por meio da avaliação de sua associação com variáveis antropométricas materna, placentária e fetal ao nascimento e as relações entre os compartimentos avaliados. MÉTODOS: em estudo transversal foi incluída amostra de 33 gestações únicas, a termo, com fetos saudáveis. As variáveis avaliadas foram idade materna, peso materno, índice de massa corporal, peso do recém-nascido, peso placentário e índice placentário. Amostras de sangue materno foram obtidas imediatamente antes do parto e em sangue do cordão umbilical ao nascimento. A dosagem da leptina sérica foi realizada por meio de radioimunoensaio convencional. As relações entre as concentrações de leptina sérica materna e da artéria e veia umbilicais com as variáveis de estudo foram verificadas através da regressão linear. RESULTADOS: a leptina foi detectada no sangue de todas as 33 gestantes e seus respectivos recém-nascidos, sendo a concentração no sangue materno (17,1±1,77 ng/ml superior à dos vasos umbilicais (veia 9,0±1,16 ng/mL; artéria 8,2±1,02 ng/mL, pPURPOSE: to evaluate the importance of circulating maternal and fetal leptin in the healthy gestation, using its association with maternal, placental and fetal anthropometric variables, obtained at birth, and the relationship between the evaluated compartments. METHODS: in a transversal study a population of 33 single, healthy and term gestations was studied. The evaluated variables were maternal age, maternal weight, body mass index (BMF, weight of the newborn, placental weight, and placental index. Samples of maternal blood were immediately obtained before birth and from fetal umbilical cord blood at birth. Determination of serum leptin was performed using conventional radioimmunoassay. The relationships between serum leptin concentrations in maternal blood, umbilical artery and vein and the studied variables were assessed through linear regression. RESULTS: leptin levels were detected in the blood of all 33 pregnant women and their respective newborns, with maternal blood concentration (17.1±1.77 ng/mL higher than that of umbilical vessels (vein: 9.0±1.16 ng/mL; artery: 8.23±1.02 ng/mL, p<0.0001. Leptin concentrations in the maternal blood were correlated with leptin concentrations in fetal blood (artery: coef. 0.63, p=0.037; vein: coef. 0.72, p=0.006. Regarding the anthropometric variables, leptin measured in the maternal blood was associated with initial and final maternal BMF (coef. 1.13; p=0.002; coef. 1,18, p=0.001 and cord leptin levels were correlated with the fetal weight at birth (vein: coef. 0.007, p=0.02; artery: coef. 0.006, p=0.02. CONCLUSION: there was a correlation between maternal and fetal leptin production and probably by the action of similar stimuli during gestation. Serum leptin was associated with the weight of the compartment where it circulates.

  3. Triploidia fetal associada à diminuição da subunidade beta e do estriol não-conjugado no soro materno Fetal triploidy associated with low levels of unconjugated estriol and beta-subunit in maternal serum

    Directory of Open Access Journals (Sweden)

    Eduardo Vieira Neto

    1999-05-01

    Full Text Available Relatamos um caso de triploidia fetal não-molar detectada na 20ª semana gestacional por cordocentese realizada em razão de estudo ultra-sonográfico que revelou retardo do crescimento intra-uterino e grave oligoidrâmnio. Na 19ª semana foram verificados acentuada diminuição da subunidade beta livre da gonadotrofina coriônica humana e do estriol não-conjugado e níveis de alfa-fetoproteína normais, apontando para um risco aumentado de síndrome de Edwards. Houve morte fetal um dia após a cordocentese e a resolução do caso foi por parto vaginal induzido com misoprostol e ocitocina, sob analgesia peridural. Estudo cromossômico das células sangüíneas fetais revelou o cariótipo 69,XXX. O grave retardo do crescimento intra-uterino, a macrocefalia, constatada no estudo anatomopatológico do feto, e os níveis muito baixos de hCG e de estriol não-conjugado sugerem um caso de triploidia por diginia, fertilização de um óvulo diplóide por um espermatozóide haplóide.We report a case of nonmolar fetal triploidy detected by fetal blood sampling at 20 weeks of gestation, performed as an investigation of intrauterine growth retardation and severe oligohydramnios found by ultrasound scan. At 19 weeks of gestation very low levels of maternal free serum beta-subunit of human chorionic gonadotropin and unconjugated estriol, and normal levels of alpha-fetoprotein were found, which were interpreted as a high risk of fetal Edwards syndrome. Fetal death supervened the day after fetal blood sampling, and the pregnancy was terminated by vaginal delivery induced by misoprostol and oxytocin, under epidural anesthesia. Chromosome study of the fetal blood cells showed a 69,XXX karyotype. The severe intrauterine growth retardation and macrocephaly noted on pathological review plus the very low levels of hCG and unconjugated estriol suggest a fetal gynoid triploidy case, caused by the fertilization of a diploid egg by a haploid sperm.

  4. Potential Benefits and Harms of Intermittent Energy Restriction and Intermittent Fasting Amongst Obese, Overweight and Normal Weight Subjects—A Narrative Review of Human and Animal Evidence

    OpenAIRE

    Howell, Anthony; Harvie, Michelle

    2017-01-01

    Intermittent energy restriction (IER) has become popular as a means of weight control amongst people who are overweight and obese, and is also undertaken by normal weight people hoping spells of marked energy restriction will optimise their health. This review summarises randomised comparisons of intermittent and isoenergetic continuous energy restriction for weight loss to manage overweight and obesity. It also summarises the potential beneficial or adverse effects of IER on body composition...

  5. Affecting Factors and Outcome on Intermittent Internet Pulling Behavior in Taiwan's Undergraduate Students

    Science.gov (United States)

    Yang, Hui-Jen; Lay, Yun-Long

    2011-01-01

    Nowadays people's lives heavily rely on Internet facilities. Internet users generally have constant Internet connectivity and intermittently click on sites they want to access even amidst studying or working. In this study, we sought to examine the factors affecting intermittent Internet pulling behavior on undergraduate students. Furthermore, the…

  6. Temporal trajectories of novel object recognition performance in mice exposed to intermittent hypoxia.

    Science.gov (United States)

    Gozal, David; Khalyfa, Abdelnaby; Qiao, Zhuanghong; Almendros, Isaac; Farré, Ramon

    2017-12-01

    Intermittent hypoxia is one of the major perturbations of sleep-disordered breathing and has been causally implicated in neurocognitive deficits. However, the reversibility of such deficits is unclear.Male C57BL/6J mice were exposed to either intermittent hypoxia or room air for 3-240 days, and then half were randomly selected and allowed to recover in normoxic conditions for the same duration of the previous exposure. A novel object recognition (NOR) test was performed.NOR performance was stable over time in room air. Intermittent hypoxia induced significant reductions in recognition index that progressed over the first 45 days and stabilised thereafter. Normoxic recovery of recognition index was essentially complete and indistinguishable from room air in mice exposed to shorter intermittent hypoxia times (<90 days). However, significant residual deficits emerged after normoxic recovery following prolonged intermittent hypoxia exposures (p<0.01). In addition, gradual attenuation of the magnitude of recovery in recognition index occurred with increasingly longer intermittent hypoxia exposures (MANOVA p<0.0001).Intermittent hypoxia during the resting period reduces NOR performance in a time-dependent fashion. Reversal of NOR performance deficits is unlikely after prolonged intermittent hypoxia duration. These findings suggest that early recognition of sleep apnoea and effective treatment are critical for restoration of the adverse cognitive effects of the disease. Copyright ©ERS 2017.

  7. Modes of water renewal and flushing in a small intermittently closed estuary

    CSIR Research Space (South Africa)

    Slinger, JH

    2017-09-01

    Full Text Available ; Kennish, 2002; King and Brown, 2006; Richter, 2010; Schallenberg et al., 2010). Of specific concern are small, bar-blocked estuaries that may close intermittently, also referred to as TOCEs (temporarily open/closed estuaries) or ICOLLs (intermittently...

  8. Impact of syllable stress and phonetic vowel context on the distribution of intermittent aphonia

    DEFF Research Database (Denmark)

    Iwarsson, Jenny; Fredsø, Julie

    2014-01-01

    with intermittent aphonia are not totally randomly appearing, but related to syllable stress and phonetic context. Recordings of 31 dysphonic patients with intermittent aphonia reading a standard text were analyzed perceptually. All vowels of the text were labelled and categorized with regard to syllable stress...

  9. Radial evolution of the intermittency of density fluctuations in the fast solar wind

    International Nuclear Information System (INIS)

    Bruno, R.; D'Amicis, R.; Telloni, D.; Primavera, L.; Sorriso-Valvo, L.; Carbone, V.; Malara, F.; Veltri, P.; Pietropaolo, E.

    2014-01-01

    We study the radial evolution of the intermittency of density fluctuations in the fast solar wind. The study is performed by analyzing the plasma density measurements provided by Helios 2 in the inner heliosphere between 0.3 and 0.9 AU. The analysis is carried out by means of a complete set of diagnostic tools, including the flatness factor at different timescales to estimate intermittency, the Kolmogorov-Smirnov test to estimate the degree of intermittency, and the Fourier transform to estimate the power spectral densities of these fluctuations. Density fluctuations within the fast wind are rather intermittent and their level of intermittency, together with the amplitude of intermittent events, decreases with the distance from the Sun, at odds with the intermittency of both magnetic field and all other plasma parameters. Furthermore, the intermittent events are strongly correlated, exhibiting temporal clustering. This indicates that the mechanism underlying their generation departs from a time-varying Poisson process. A remarkable, qualitative similarity with the behavior of plasma density fluctuations obtained from a numerical study of the nonlinear evolution of parametric instability in the solar wind supports the idea that this mechanism has an important role in governing density fluctuations in the inner heliosphere.

  10. Intermittent turbulence and oscillations in the stable boundary layer over land

    NARCIS (Netherlands)

    Wiel, van de B.

    2002-01-01

    As the title of this thesis indicates, our main subject of interest is: "Intermittent turbulence and oscillation in the stable boundary layer over land". As such, this theme connects the different chapters. Here, intermittent turbulence is defined as a sequence of events were 'burst' of

  11. Determining order-up-to levels under periodic review for compound binomial (intermittent) demand

    NARCIS (Netherlands)

    Teunter, R. H.; Syntetos, A. A.; Babai, M. Z.

    2010-01-01

    We propose a new method for determining order-up-to levels for intermittent demand items in a periodic review system. Contrary to existing methods, we exploit the intermittent character of demand by modelling lead time demand as a compound binomial process. in an extensive numerical study using

  12. 29 CFR 825.202 - Intermittent leave or reduced leave schedule.

    Science.gov (United States)

    2010-07-01

    ... accommodated through an intermittent or reduced leave schedule. The treatment regimen and other information... treatment by a health care provider. See §§ 825.113 and 825.127. (c) Birth or placement. When leave is taken... 29 Labor 3 2010-07-01 2010-07-01 false Intermittent leave or reduced leave schedule. 825.202...

  13. 29 CFR 825.203 - Scheduling of intermittent or reduced schedule leave.

    Science.gov (United States)

    2010-07-01

    ... leave intermittently or on a reduced leave schedule for planned medical treatment, then the employee... 29 Labor 3 2010-07-01 2010-07-01 false Scheduling of intermittent or reduced schedule leave. 825... OF LABOR OTHER LAWS THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Employee Leave Entitlements Under the...

  14. Intermittency in delay-coupled FitzHugh–Nagumo oscillators and ...

    Indian Academy of Sciences (India)

    out intermittency occurs. We introduce a definition of phase such that loss of phase synchrony can be used as a precursor to the intermittent behavior. This sys- tem is comprised of two identical FitzHugh–Nagumo. (FHN) oscillators which are coupled to each other using multiple time-delay diffusive couplings. Such a form of.

  15. The influence of basketball dribbling on repeated high-intensity intermittent runs

    Directory of Open Access Journals (Sweden)

    Zhaowei Kong

    2015-12-01

    Conclusion: The results suggest that the Yo-Yo IE2 test could reflect the repeatability of high-intensity intermittent basketball dribbling performance, while dribbling skills may have different influences on high-intensity intermittent exercise capacity in adolescent players at different ages.

  16. Quantifying spatial and temporal patterns of flow intermittency using spatially contiguous runoff data

    Science.gov (United States)

    Yu (于松延), Songyan; Bond, Nick R.; Bunn, Stuart E.; Xu, Zongxue; Kennard, Mark J.

    2018-04-01

    River channel drying caused by intermittent stream flow is a widely-recognized factor shaping stream ecosystems. There is a strong need to quantify the distribution of intermittent streams across catchments to inform management. However, observational gauge networks provide only point estimates of streamflow variation. Increasingly, this limitation is being overcome through the use of spatially contiguous estimates of the terrestrial water-balance, which can also assist in estimating runoff and streamflow at large-spatial scales. Here we proposed an approach to quantifying spatial and temporal variation in monthly flow intermittency throughout river networks in eastern Australia. We aggregated gridded (5 × 5 km) monthly water-balance data with a hierarchically nested catchment dataset to simulate catchment runoff accumulation throughout river networks from 1900 to 2016. We also predicted zero flow duration for the entire river network by developing a robust predictive model relating measured zero flow duration (% months) to environmental predictor variables (based on 43 stream gauges). We then combined these datasets by using the predicted zero flow duration from the regression model to determine appropriate 'zero' flow thresholds for the modelled discharge data, which varied spatially across the catchments examined. Finally, based on modelled discharge data and identified actual zero flow thresholds, we derived summary metrics describing flow intermittency across the catchment (mean flow duration and coefficient-of-variation in flow permanence from 1900 to 2016). We also classified the relative degree of flow intermittency annually to characterise temporal variation in flow intermittency. Results showed that the degree of flow intermittency varied substantially across streams in eastern Australia, ranging from perennial streams flowing permanently (11-12 months) to strongly intermittent streams flowing 4 months or less of year. Results also showed that the

  17. Intermittent Fasting Modulation of the Diabetic Syndrome in Streptozotocin-Injected Rats

    Directory of Open Access Journals (Sweden)

    Louiza Belkacemi

    2012-01-01

    Full Text Available This study investigates the effects of intermittent overnight fasting in streptozotocin-induced diabetic rats (STZ rats. Over 30 days, groups of 5-6 control or STZ rats were allowed free food access, starved overnight, or exposed to a restricted food supply comparable to that ingested by the intermittently fasting animals. Intermittent fasting improved glucose tolerance, increased plasma insulin, and lowered Homeostatis Model Assessment index. Caloric restriction failed to cause such beneficial effects. The β-cell mass, as well as individual β-cell and islet area, was higher in intermittently fasting than in nonfasting STZ rats, whilst the percentage of apoptotic β-cells appeared lower in the former than latter STZ rats. In the calorie-restricted STZ rats, comparable findings were restricted to individual islet area and percentage of apoptotic cells. Hence, it is proposed that intermittent fasting could represent a possible approach to prevent or minimize disturbances of glucose homeostasis in human subjects.

  18. Type III intermittency: a nonlinear dynamic model of EEG burst suppression.

    Science.gov (United States)

    Rae-Grant, A D; Kim, Y W

    1994-01-01

    Burst suppression electroencephalograms from 9 comatose patients have been studied using nonlinear dynamic techniques. These EEG records show many dynamical features characteristic of nonlinear systems, including sensitive dependence on initial conditions, self-organization, similarity across scales, and intermittency. Histograms of burst durations showed an asymmetric distribution with a decreasing tail of increasing duration. Interpreting the histograms from the standpoint of intermittency classifications of iterated dynamical maps, the absence of any conspicuous maximal cut-off duration suggests a type III intermittency. The power-law exponent of the decreasing tail is -3/2 for type III intermittency in the large scale sample size limit, and we have found the EEGs to be consistent with type III intermittency behavior. We have also developed a nonlinear algorithm which models burst suppression pattern based on a low dimensional return map. Burst suppression pattern appears to be the constrained activity of a nonlinear dynamical system at the transition to chaos.

  19. Circuit implementation and multiform intermittency in a hyper-chaotic model extended from the Lorenz system

    International Nuclear Information System (INIS)

    Shi-Jian, Cang; Zeng-Qiang, Chen; Wen-Juan, Wu

    2009-01-01

    This paper presents a non-autonomous hyper-chaotic system, which is formed by adding a periodic driving signal to a four-dimensional chaotic model extended from the Lorenz system. The resulting non-autonomous hyper-chaotic system can display any dynamic behaviour among the periodic orbits, intermittency, chaos and hyper-chaos by controlling the frequency of the periodic signal. The phenomenon has been well demonstrated by numerical simulations, bifurcation analysis and electronic circuit realization. Moreover, the system is concrete evidence for the presence of Pomeau–Manneville Type-I intermittency and crisis-induced intermittency. The emergence of a different type of intermittency is similarly subjected to the frequency of periodic forcing. By statistical analysis, power scaling laws consisting in different intermittency are obtained for the lifetime in the laminar state between burst states

  20. Coexistence of intermittencies in the neuronal network of the epileptic brain.

    Science.gov (United States)

    Koronovskii, Alexey A; Hramov, Alexander E; Grubov, Vadim V; Moskalenko, Olga I; Sitnikova, Evgenia; Pavlov, Alexey N

    2016-03-01

    Intermittent behavior occurs widely in nature. At present, several types of intermittencies are known and well-studied. However, consideration of intermittency has usually been limited to the analysis of cases when only one certain type of intermittency takes place. In this paper, we report on the temporal behavior of the complex neuronal network in the epileptic brain, when two types of intermittent behavior coexist and alternate with each other. We prove the presence of this phenomenon in physiological experiments with WAG/Rij rats being the model living system of absence epilepsy. In our paper, the deduced theoretical law for distributions of the lengths of laminar phases prescribing the power law with a degree of -2 agrees well with the experimental neurophysiological data.

  1. Modeling Integrated Water-User Decisions with Intermittent Supplies

    Science.gov (United States)

    Lund, J. R.; Rosenberg, D.

    2006-12-01

    We present an economic-engineering method to estimate urban water use demands with intermittent water supplies. A two-stage, probabilistic optimization formulation includes a wide variety of water supply enhancement and conservation actions that individual households can adopt to meet multiple water quality uses with uncertain water availability. We embed the optimization in Monte-Carlo simulations to show aggregate effects at a utility (citywide) scale for a population of user conditions and decisions. Parametric analysis provides derivations of supply curves to subsidize conservation, demand responses to alternative pricing, and customer willingness-to-pay to avoid shortages. Results show a good empirical fit for the average and distribution of billed residential water use in Amman, Jordan. Additional outputs give likely market penetration rates for household conservation actions, associated water savings, and subsidies required to entice further adoption. We discuss new insights to size, target, market, and finance conservation programs and interpret a demand curve with block pricing.

  2. Modeling integrated water user decisions in intermittent supply systems

    Science.gov (United States)

    Rosenberg, David E.; Tarawneh, Tarek; Abdel-Khaleq, Rania; Lund, Jay R.

    2007-07-01

    We apply systems analysis to estimate household water use in an intermittent supply system considering numerous interdependent water user behaviors. Some 39 household actions include conservation; improving local storage or water quality; and accessing sources having variable costs, availabilities, reliabilities, and qualities. A stochastic optimization program with recourse decisions identifies the infrastructure investments and short-term coping actions a customer can adopt to cost-effectively respond to a probability distribution of piped water availability. Monte Carlo simulations show effects for a population of customers. Model calibration reproduces the distribution of billed residential water use in Amman, Jordan. Parametric analyses suggest economic and demand responses to increased availability and alternative pricing. It also suggests potential market penetration for conservation actions, associated water savings, and subsidies to entice further adoption. We discuss new insights to size, target, and finance conservation.

  3. Intermittent Motion, Nonlinear Diffusion Equation and Tsallis Formalism

    Directory of Open Access Journals (Sweden)

    Ervin K. Lenzi

    2017-01-01

    Full Text Available We investigate an intermittent process obtained from the combination of a nonlinear diffusion equation and pauses. We consider the porous media equation with reaction terms related to the rate of switching the particles from the diffusive mode to the resting mode or switching them from the resting to the movement. The results show that in the asymptotic limit of small and long times, the spreading of the system is essentially governed by the diffusive term. The behavior exhibited for intermediate times depends on the rates present in the reaction terms. In this scenario, we show that, in the asymptotic limits, the distributions for this process are given by in terms of power laws which may be related to the q-exponential present in the Tsallis statistics. Furthermore, we also analyze a situation characterized by different diffusive regimes, which emerges when the diffusive term is a mixing of linear and nonlinear terms.

  4. Intermittency-friendly and high-efficiency cogeneration

    DEFF Research Database (Denmark)

    Blarke, Morten; Dotzauer, Erik

    2011-01-01

    This paper develops, implements, and applies a mathematical model for economic unit dispatch for a novel cogeneration concept (CHP-HP-FG-CS (CHP with compression heat pump and cold storage using flue gas heat)) that increases the plant’s operational flexibility. The CHP-HP-FG-CS concept is a high......-temperature heat source, and an intermediate cold thermal storage allowing for non-concurrent operation of the cogeneration unit and the heat pump unit. The model is applied for a paradigmatic case study that shows how the integration of a heat pump affects the operational strategy of a cogeneration plant......-efficiency and widely applicable option in distributed cogeneration better supporting the co-existence between cogenerators and intermittent renewables in the energy system. The concept involves integrating an efficient high-temperature compression heat pump that uses only waste heat recovered from flue gases as low...

  5. A new device to mimic intermittent hypoxia in mice.

    Directory of Open Access Journals (Sweden)

    Kamil J Chodzyński

    Full Text Available Intermittent hypoxia (hypoxia-reoxygenation is often associated with cardiovascular morbidity and mortality. We describe a new device which can be used to submit cohorts of mice to controlled and standardised hypoxia-normoxia cycles at an individual level. Mice were placed in individual compartments to which similar gas flow parameters were provided using an open loop strategy. Evaluations made using computational fluid dynamics were confirmed by studying changes in haemoglobin oxygen saturation in vivo. We also modified the parameters of the system and demonstrated its ability to generate different severities of cyclic hypoxemia very precisely, even with very high frequency cycles of hypoxia-reoxygenation. The importance of the parameters on reoxygenation was shown. This device will allow investigators to assess the effects of hypoxia-reoxygenation on different pathological conditions, such as obstructive sleep apnoea or chronic obstructive pulmonary disease.

  6. Intermittent Noise Induces Physiological Stress in a Coastal Marine Fish.

    Directory of Open Access Journals (Sweden)

    Tye A Nichols

    Full Text Available Anthropogenic noise in the ocean has increased substantially in recent decades, and motorized vessels produce what is likely the most common form of underwater noise pollution. Noise has the potential to induce physiological stress in marine fishes, which may have negative ecological consequences. In this study, physiological effects of increased noise (playback of boat noise recorded in the field on a coastal marine fish (the giant kelpfish, Heterostichus rostratus were investigated by measuring the stress responses (cortisol concentration of fish to increased noise of various temporal dynamics and noise levels. Giant kelpfish exhibited acute stress responses when exposed to intermittent noise, but not to continuous noise or control conditions (playback of recorded natural ambient sound. These results suggest that variability in the acoustic environment may be more important than the period of noise exposure for inducing stress in a marine fish, and provide information regarding noise levels at which physiological responses occur.

  7. Turbulent statistics and intermittency enhancement in coflowing superfluid 4He

    Science.gov (United States)

    Biferale, L.; Khomenko, D.; L'vov, V.; Pomyalov, A.; Procaccia, I.; Sahoo, G.

    2018-02-01

    The large-scale turbulent statistics of mechanically driven superfluid 4He was shown experimentally to follow the classical counterpart. In this paper, we use direct numerical simulations to study the whole range of scales in a range of temperatures T ∈[1.3 ,2.1 ] K. The numerics employ self-consistent and nonlinearly coupled normal and superfluid components. The main results are that (i) the velocity fluctuations of normal and super components are well correlated in the inertial range of scales, but decorrelate at small scales. (ii) The energy transfer by mutual friction between components is particulary efficient in the temperature range between 1.8 and 2 K, leading to enhancement of small-scale intermittency for these temperatures. (iii) At low T and close to Tλ, the scaling properties of the energy spectra and structure functions of the two components are approaching those of classical hydrodynamic turbulence.

  8. Implementing intermittent preventive treatment for malaria in pregnancy

    DEFF Research Database (Denmark)

    Mubyazi, Godfrey Martin; Magnussen, Pascal; Goodman, Catherine

    2011-01-01

    Introduction Implementing Intermittent Preventive Treatment for malaria in Pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) through antenatal care (ANC) clinics is recommended for malaria endemic countries. The vast biomedical literature on malaria prevention focuses more on the epidemiological....... Results The importance of IPTp in preventing unnecessary anaemia, morbidity and mortality in pregnancy and improving childbirth outcomes is highly acknowledged, although the following factors appear to be the main constraints to IPTp service delivery and uptake: cost of accessing ANC; myths and other...... discriminatory socio-cultural values on and attitudes towards SP, malaria, and quality of ANC; supply and cost of SP at health facilities; understaffing and demoralised staff; ambiguity and impracticability of user-fee exemption policy guidelines on essential ANC services; implementing IPTp, bednets, HIV...

  9. Intermittent fasting attenuates inflammasome activity in ischemic stroke.

    Science.gov (United States)

    Fann, David Yang-Wei; Santro, Tomislav; Manzanero, Silvia; Widiapradja, Alexander; Cheng, Yi-Lin; Lee, Seung-Yoon; Chunduri, Prasad; Jo, Dong-Gyu; Stranahan, Alexis M; Mattson, Mark P; Arumugam, Thiruma V

    2014-07-01

    Recent findings have revealed a novel inflammatory mechanism that contributes to tissue injury in cerebral ischemia mediated by multi-protein complexes termed inflammasomes. Intermittent fasting (IF) can decrease the levels of pro-inflammatory cytokines in the periphery and brain. Here we investigated the impact of IF (16h of food deprivation daily) for 4months on NLRP1 and NLRP3 inflammasome activities following cerebral ischemia. Ischemic stroke was induced in C57BL/6J mice by middle cerebral artery occlusion, followed by reperfusion (I/R). IF decreased the activation of NF-κB and MAPK signaling pathways, the expression of NLRP1 and NLRP3 inflammasome proteins, and both IL-1β and IL-18 in the ischemic brain tissue. These findings demonstrate that IF can attenuate the inflammatory response and tissue damage following ischemic stroke by a mechanism involving suppression of NLRP1 and NLRP3 inflammasome activity. Copyright © 2014 Elsevier Inc. All rights reserved.

  10. High-Intensity Intermittent Exercise and Fat Loss

    Directory of Open Access Journals (Sweden)

    Stephen H. Boutcher

    2011-01-01

    Full Text Available The effect of regular aerobic exercise on body fat is negligible; however, other forms of exercise may have a greater impact on body composition. For example, emerging research examining high-intensity intermittent exercise (HIIE indicates that it may be more effective at reducing subcutaneous and abdominal body fat than other types of exercise. The mechanisms underlying the fat reduction induced by HIIE, however, are undetermined. Regular HIIE has been shown to significantly increase both aerobic and anaerobic fitness. HIIE also significantly lowers insulin resistance and results in a number of skeletal muscle adaptations that result in enhanced skeletal muscle fat oxidation and improved glucose tolerance. This review summarizes the results of HIIE studies on fat loss, fitness, insulin resistance, and skeletal muscle. Possible mechanisms underlying HIIE-induced fat loss and implications for the use of HIIE in the treatment and prevention of obesity are also discussed.

  11. Managing intermittent sources of electricity: the prospects opened by research

    International Nuclear Information System (INIS)

    Bigot, Bernard

    2013-01-01

    Beyond the difficult question of foreseeing the additional cost of placing one kWh of electricity on the grid - a cost that must be kept as low as possible to improve the technology for harnessing and converting energy - the growing share of electricity from renewable energy sources in national consumption (initially in replacement of fossil fuels) raises questions for research. How to limit the factors that make most of these forms of energy intermittent? One solution involves developing local or centralized storage capacities that are technically and economically efficient. Another proposal has to do with introducing information technology in electricity grids and electric appliances in order to reverse the currently prevailing rationale so that demand adjusts to supply, and not the reverse, in proportions that, though probably limited, are indispensable

  12. The limits of the integration of intermittent electricity productions

    International Nuclear Information System (INIS)

    Nifenecker, Herve

    2013-01-01

    Addressing the issue of intermittency of renewable energies and the associated need of an available spare energy, the author states that the installed nuclear power cannot be significantly decreased by a development of photovoltaic and wind energy productions. He shows that the maximum share of renewable energy which can be used in the energy mix is its load factor. In the case of wind energy, he formulates a set of theorems which notably address the possibilities to avoid an overproduction of wind energy, the assessment of the controllable production, the maximum share of wind energy. Based on these theorems, he computes the purchase cost of wind energy and the avoided cost of nuclear production. He addresses the case of photovoltaic energy for which he outlines the perspectives and obstacles related to energy storage

  13. Intermittent Testing and Training for High-Level Football Players

    DEFF Research Database (Denmark)

    Ingebrigtsen, Jørgen

    Football is the most popular sport in the world, played by over 400 million men and women. In addition to the wide range of sport-specific technical and tactical skills needed, several physical components have been shown to be necessary to perform at a high level. The present PhD thesis is based...... on four articles that focus on physical testing and training for elite and sub-elite football players.The first article (Study I) aims to identify and establish aerobic capacities and anthropometric characteristics of elite female football players with the use of laboratory tests, and to examine whether...... systematic differences between the playing positions can be detected. Lately, field tests have become more frequently used in football than the laboratory tests used in Study I. Study II therefore aims to assess the validity of one of them, the Yo-Yo Intermittent Recovery test level 2 (Yo-Yo IR2). Along...

  14. Floating tumor debris. A cause of intermittent biliary obstruction.

    Science.gov (United States)

    Roslyn, J J; Kuchenbecker, S; Longmire, W P; Tompkins, R K

    1984-11-01

    Tumor debris, free-floating in the major biliary ductal system, is a cause of intermittent biliary obstruction that has previously not been recognized. Six patients had hepatic neoplasms with episodic jaundice and/or cholangitis due to floating tumor debris. Diagnosis included metastatic adenocarcinoma of the colon (n = 3), cholangiocarcinoma (n = 1), hepatocellular carcinoma (n = 1), and cavernous hemangioma (n = 1). All patients underwent biliary exploration, with hepatic resection and transhepatic intubation in two and T-tube placement in four. One patient died in the early postoperative period, and the major complication rate in the five survivors was 0%. Four of the five survivors had no further episodes suggestive of major bile duct obstruction. Our experience emphasizes the importance of distinguishing extrahepatic obstruction secondary to tumor debris from the more common causes of jaundice in patients with tumors and suggests that safe and effective palliation can be achieved in these patients.

  15. Coherent structures, dissipation and intermittency in plasma turbulence

    Science.gov (United States)

    Wan, M.; Matthaeus, W. H.; Roytershteyn, V.; Parashar, T.; Shay, M. A.; Karimabadi, H.; Wu, P.

    2015-12-01

    The nature of collisionless dissipation in turbulent plasmas such as the solar wind and the solar corona has been hotly debated recently. Here we report results from high resolution, fully kinetic simulations of plasmas turbulence in both two and three dimensions. The simulations show development of turbulent coherent structures, characterized by sheet-like current density structures spanning a range of scales. Results from particle-in-cell (PIC) simulations are also compared with MHD simulations in terms of coherent structures, dissipation and intermittency. An important conclusion, for all simulations examined, is that the dissipation is concentrated in very small volumes, reminiscent of the scenario that motivates the Kolmogorov refined similarity hypothesis in hydrodynamic turbulence. Extrapolated to large heliospheric system sizes, this leads to the expectation of significant departures from heating processes that operate uniformly in space. Results from latest 3D driven PIC simulations, as well as the connection to solar wind observations, will also be discussed.

  16. Implementing intermittent preventive treatment for malaria in pregnancy

    DEFF Research Database (Denmark)

    Mubyazi, Godfrey Martin; Magnussen, Pascal; Goodman, Catherine

    2008-01-01

    INTRODUCTION: Implementing Intermittent Preventive Treatment for malaria in Pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) through antenatal care (ANC) clinics is recommended for malaria endemic countries. Vast biomedical literature on malaria prevention focuses more on the epidemiological...... of the recommended interventions. OBJECTIVE: To review literature on policy advances, achievements, constraints and challenges to malaria IPTp implementation, emphasising on its operational feasibility in the context of health-care financing, provision and uptake, resource constraints and psychosocial factors...... and other discriminatory socio-cultural values on pregnancy; target users, perceptions and attitudes towards SP, malaria, and quality of ANC; supply and cost of SP at health facilities; understaffing and demoralised staff; ambiguity and impracticability of user-fee exemption policy guidelines on essential...

  17. Red cell survival and sequestration in acute intermittent porphyria

    International Nuclear Information System (INIS)

    Nawalkha, P.L.; Soni, S.G.; Agrawal, V.K.; Misra, S.N.

    1980-01-01

    Life span and sequestration of red cells have been studied in twenty one proved cases of acute intermittent porphyria of different age and sex group from Bikaner District, Rajasthan State (India). Chromium-51 labelled red cells were used in the study and the excess count method of Bughe Jones and Szur was used to calculate the index of sequestration. The mean apparent half survival time of erythrocytes in the control subjects was 25.9 +- 2.9 (S.D.) days and the same in the prophyria patients was 27.0 +- 3.8 days. This shows that the life span of red cells is normal in both the patient and the control. Excess destruction of red blood cells was found to take place in either spleen or liver in the disease and no excess accumulation of erythrocytes occurred over spleen as compared to liver. (M.G.B.)

  18. Implementing intermittent preventive treatment for malaria in pregnancy

    DEFF Research Database (Denmark)

    Mubyazi, Godfrey Martin; Magnussen, Pascal; Goodman, Catherine

    2011-01-01

    Introduction Implementing Intermittent Preventive Treatment for malaria in Pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) through antenatal care (ANC) clinics is recommended for malaria endemic countries. The vast biomedical literature on malaria prevention focuses more on the epidemiological...... of the recommended interventions. Objective To review literature on policy advances, achievements, constraints and challenges to malaria IPTp implementation, emphasising its operational feasibility in the context of health-care financing, provision and uptake, resource constraints and psychosocial factors in Africa...... discriminatory socio-cultural values on and attitudes towards SP, malaria, and quality of ANC; supply and cost of SP at health facilities; understaffing and demoralised staff; ambiguity and impracticability of user-fee exemption policy guidelines on essential ANC services; implementing IPTp, bednets, HIV...

  19. Intermittent Noise Induces Physiological Stress in a Coastal Marine Fish.

    Science.gov (United States)

    Nichols, Tye A; Anderson, Todd W; Širović, Ana

    2015-01-01

    Anthropogenic noise in the ocean has increased substantially in recent decades, and motorized vessels produce what is likely the most common form of underwater noise pollution. Noise has the potential to induce physiological stress in marine fishes, which may have negative ecological consequences. In this study, physiological effects of increased noise (playback of boat noise recorded in the field) on a coastal marine fish (the giant kelpfish, Heterostichus rostratus) were investigated by measuring the stress responses (cortisol concentration) of fish to increased noise of various temporal dynamics and noise levels. Giant kelpfish exhibited acute stress responses when exposed to intermittent noise, but not to continuous noise or control conditions (playback of recorded natural ambient sound). These results suggest that variability in the acoustic environment may be more important than the period of noise exposure for inducing stress in a marine fish, and provide information regarding noise levels at which physiological responses occur.

  20. Intermittent pressure decreases human keratinocyte proliferation in vitro.

    Science.gov (United States)

    Nasca, Maria R; Shih, Alan T; West, Dennis P; Martinez, Wanda M; Micali, Giuseppe; Landsman, Adam S

    2007-01-01

    The aim of this study was to investigate the correlation between pressure changes and keratinocyte proliferation by determining whether keratinocytes exposed to altered mechanical pressures would proliferate at different rates compared to control cells not subjected to pressure changes. Tissue culture flasks of human keratinocytes plated at an approximate density of 15,000 cells/cm(2) undergoing an intermittent cyclic pressure of 362 mm Hg at a frequency of 2.28 or 5.16 cycles/min (0.038 or 0.086 Hz) for 8 h were compared to control flasks grown at ambient room pressure. An in-line pressure transducer was used to monitor and adjust pressure within the cell chambers, using a solenoid valve. A thymidine incorporation assay assessed the amount of cell proliferation in each set of experiments. Differences in proliferation between keratinocytes subjected to cyclic pressure changes and control cells were found to be statistically significant (p < 0.05) in 4 out of 5 proliferation assays. Also, a higher frequency of pressure changes consistently generated a reduced proliferation rate compared to that seen in cells exposed to a lower frequency of pressure changes. These data indicate that keratinocytes undergoing intermittent pressure changes exhibit decreased proliferation rates compared to controls. Furthermore, an increased frequency rate seems to have a greater effect on proliferation than low-frequency rate pressure changes, suggesting that the stress caused by frequently changed pressure may play a greater role in reducing keratinocyte proliferation than the actual magnitude of load applied to the cells. Our results support the current treatment protocol of reducing speed and duration of walking on the site of the wound to promote healing of foot ulcers. (c) 2007 S. Karger AG, Basel.

  1. Ecoulements intermittents de gaz et de liquide en conduite verticale Intermittent Gas and Liquid Flows in a Vertical Pipe.

    Directory of Open Access Journals (Sweden)

    Line A.

    2006-11-01

    Full Text Available Le modèle présenté ici permet la pré-détermination du gradient de pression, du taux global de gaz, et de grandeurs caractéristiques de l'intermittence, dans un écoulement à poches et bouchons en conduite verticale. L'écriture des lois de conservation en moyenne phasique conditionnelle conduit à la définition d'une cellule moyenne équivalente. La fermeture du modèle est assurée par des lois de contrainte de cisaillement film-paroi, film-poche, bouchon-paroi, par une loi d'arrachage du gaz au culot de la poche, une loi de glissement du gaz dans les bouchons et par une loi de la vitesse moyenne de propagation des fronts de poches. Le calibrage et la qualification du modèle s'appuient sur deux banques de données, dont l'une a été obtenue avec des fluides pétroliers dans des conditions proches des situations industrielles (boucle diphasique de Boussens. The model described here can be used to predetermine the pressure gradient, the overall gas rate and the characteristic intermittence magnitudes in pocket and slug flow in a vertical pipe. The way governing equations in the conditional phase average are written defines an equivalent average cell. The model is closed by film/wall, film/pocket and slug/wall shear-stress laws, by a pulloff law for the gas at the bottom of the pocket, a slippage law for the gas in the slugs, and a mean propagation velocity law for the pocket fronts. The calibration and qualification of the model are based on two data banks, one of which contains data on petroleum fluids under conditions close to industrial situations (two-phase loop at Boussens.

  2. Effect of Intermittent Hypoxic Training Followed by Intermittent Hypoxic Exposure on Aerobic Capacity of Long Distance Runners.

    Science.gov (United States)

    Nakamoto, Fernanda P; Ivamoto, Rafael K; Andrade, Marilia Dos S; de Lira, Claudio A B; Silva, Bruno M; da Silva, Antonio C

    2016-06-01

    Effects of intermittent hypoxic training (IHT) are still controversial and detraining effects remain uninvestigated. Therefore, we investigated (a) whether IHT improves aerobic capacity; (b) whether aerobic detraining occurs post-IHT; and (c) whether intermittent hypoxic exposure (IHE) at rest reduces a possible aerobic detraining post-IHT. Twenty eight runners (21 men/7 women; 36 ± 2 years; maximal oxygen uptake [V[Combining Dot Above]O2max] 55.4 ± 1.3 ml·kg·min) participated in a single-blinded placebo-controlled trial. Twice a week, 1 group performed 6 weeks of IHT (n = 11), followed by 4 weeks of IHE (n = 11) at rest (IHT+IHE group). Another group performed 6 weeks of IHT (n = 10), followed by 4 weeks of normoxic exposure (NE, n = 9) at rest (IHT+NE group). A control group performed 6 weeks of normoxic training (NT, n = 7), followed by 4 weeks of NE (n = 6) at rest (NT+NE group). Hematological and submaximal/maximal aerobic measurements were conducted in normoxia at pretraining, posttraining, and postexposure. Hemoglobin concentration did not change, but lactate threshold and running economy improved in all groups at posttraining (p ≤ 0.05 vs. pretraining). Ventilatory threshold, respiratory compensation point, and V[Combining Dot Above]O2max increased after IHT (IHT+IHE group: 7.3, 5.4, and 9.2%, respectively; IHT+NE group: 10.7, 7.5, and 4.8%; p ≤ 0.05 vs. pretraining), but not after NT (-1.1, -1.0, and -3.8%; p > 0.05 vs. pretraining). Such IHT-induced adaptations were maintained at postexposure (p > 0.05 vs. postexposure). In conclusion, IHT induced further aerobic improvements than NT. These additional IHT adaptations were maintained for 4 weeks post-IHT, regardless of IHE.

  3. Quality of plant-based food materials and its prediction during intermittent drying.

    Science.gov (United States)

    Duc Pham, Nghia; Khan, Md Imran H; Joardder, M U H; Rahman, M M; Mahiuddin, Md; Abesinghe, A M Nishani; Karim, M A

    2017-11-30

    In most drying processes, several physical, chemical and nutritional modifications take place in food products. Innovative drying techniques such as intermittent drying can enhance the quality of dehydrated products effectively and efficiently. Intermittent drying is a technique where drying conditions are changed through varying the drying air temperature, humidity, velocity, pressure, or even mode of heat input. This drying technique has been successfully applied to overcome the problems of conventional drying systems such as longer time consumption, case hardening, lower energy efficiency and poor-quality attributes. However, as the effect of intermittent drying on food quality is not yet well understood, a comprehensive study of quality change during intermittent drying is crucial. The main aim of this paper is to present a thorough review of the potential effect of intermittent drying methods on physical, chemical, nutritional, and stability characteristics of plant-based food material. It is found that application of intermittency using different drying systems has a significant effect on product quality and its stability. In addition, a comprehensive review on existing models of physio/biochemical kinetics for food drying is presented. Finally, the paper is concluded with the discussion of the current challenges and future directions of intermittent drying for producing high-quality dried food products.

  4. EVOLUTION OF INTERMITTENCY IN THE SLOW AND FAST SOLAR WIND BEYOND THE ECLIPTIC PLANE

    Energy Technology Data Exchange (ETDEWEB)

    Wawrzaszek, A.; Macek, W. M. [Space Research Centre, Polish Academy of Sciences, Warsaw (Poland); Echim, M. [The Belgian Institute for Space Aeronomy, Brussels (Belgium); Bruno, R., E-mail: anna.wawrzaszek@cbk.waw.pl, E-mail: marius.echim@oma.be, E-mail: macek@cbk.waw.pl, E-mail: roberto.bruno@iaps.inaf.it [Institute for Space Astrophysics and Planetology, Roma (Italy)

    2015-12-01

    We study intermittency as a departure from self-similarity of the solar wind magnetic turbulence and investigate the evolution with the heliocentric distance and latitude. We use data from the Ulysses spacecraft measured during two solar minima (1997–1998 and 2007–2008) and one solar maximum (1999–2001). In particular, by modeling a multifractal spectrum, we revealed the intermittent character of turbulence in the small-scale fluctuations of the magnetic field embedded in the slow and fast solar wind. Generally, at small distances from the Sun, in both the slow and fast solar wind, we observe the high degree of multifractality (intermittency) that decreases somewhat slowly with distance and slowly with latitude. The obtained results seem to suggest that generally intermittency in the solar wind has a solar origin. However, the fast and slow streams, shocks, and other nonlinear interactions can only be considered as the drivers of the intermittent turbulence. It seems that analysis shows that turbulence beyond the ecliptic plane evolves too slowly to maintain the intermittency with the distance and latitude. Moreover, we confirm that the multifractality and intermittency are at a lower level than in the ecliptic, as well as the existence of symmetry with respect to the ecliptic plane, suggesting that there are similar turbulent properties observed in the two hemispheres.

  5. EVOLUTION OF INTERMITTENCY IN THE SLOW AND FAST SOLAR WIND BEYOND THE ECLIPTIC PLANE

    International Nuclear Information System (INIS)

    Wawrzaszek, A.; Macek, W. M.; Echim, M.; Bruno, R.

    2015-01-01

    We study intermittency as a departure from self-similarity of the solar wind magnetic turbulence and investigate the evolution with the heliocentric distance and latitude. We use data from the Ulysses spacecraft measured during two solar minima (1997–1998 and 2007–2008) and one solar maximum (1999–2001). In particular, by modeling a multifractal spectrum, we revealed the intermittent character of turbulence in the small-scale fluctuations of the magnetic field embedded in the slow and fast solar wind. Generally, at small distances from the Sun, in both the slow and fast solar wind, we observe the high degree of multifractality (intermittency) that decreases somewhat slowly with distance and slowly with latitude. The obtained results seem to suggest that generally intermittency in the solar wind has a solar origin. However, the fast and slow streams, shocks, and other nonlinear interactions can only be considered as the drivers of the intermittent turbulence. It seems that analysis shows that turbulence beyond the ecliptic plane evolves too slowly to maintain the intermittency with the distance and latitude. Moreover, we confirm that the multifractality and intermittency are at a lower level than in the ecliptic, as well as the existence of symmetry with respect to the ecliptic plane, suggesting that there are similar turbulent properties observed in the two hemispheres

  6. Comprehensive Validation of an Intermittency Transport Model for Transitional Low-Pressure Turbine Flows

    Science.gov (United States)

    Suzen, Y. B.; Huang, P. G.

    2005-01-01

    A transport equation for the intermittency factor is employed to predict transitional flows under the effects of pressure gradients, freestream turbulence intensities, Reynolds number variations, flow separation and reattachment. and unsteady wake-blade interactions representing diverse operating conditions encountered in low-pressure turbines. The intermittent behaviour of the transitional flows is taken into account and incorporated into computations by modifying the eddy viscosity, Mu(sub t), with the intermittency factor, gamma. Turbulent quantities are predicted by using Menter's two-equation turbulence model (SST). The onset location of transition is obtained from correlations based on boundary-layer momentum thickness, acceleration parameter, and turbulence intensity. The intermittency factor is obtained from a transport model which can produce both the experimentally observed streamwise variation of intermittency and a realistic profile in the cross stream direction. The intermittency transport model is tested and validated against several well documented low pressure turbine experiments ranging from flat plate cases to unsteady wake-blade interaction experiments. Overall, good agreement between the experimental data and computational results is obtained illustrating the predicting capabilities of the model and the current intermittency transport modelling approach for transitional flow simulations.

  7. Chronic intermittent hyperoxia alters the development of the hypoxic ventilatory response in neonatal rats.

    Science.gov (United States)

    Logan, Sarah; Tobin, Kristina E; Fallon, Sarah C; Deng, Kevin S; McDonough, Amy B; Bavis, Ryan W

    2016-01-01

    Chronic exposure to sustained hyperoxia alters the development of the respiratory control system, but the respiratory effects of chronic intermittent hyperoxia have rarely been investigated. We exposed newborn rats to short, repeated bouts of 30% O2 or 60% O2 (5 bouts h(-1)) for 4-15 days and then assessed their hypoxic ventilatory response (HVR; 10 min at 12% O2) by plethysmography. The HVR tended to be enhanced by intermittent hyperoxia at P4 (early phase of the HVR), but it was significantly reduced at P14-15 (primarily late phase of the HVR) compared to age-matched controls; the HVR recovered when individuals were returned to room air and re-studied as adults. To investigate the role of carotid body function in this plasticity, single-unit carotid chemoafferent activity was recorded in vitro. Intermittent hyperoxia tended to decrease spontaneous action potential frequency under normoxic conditions but, contrary to expectations, hypoxic responses were only reduced at P4 (not at P14) and only in rats exposed to higher O2 levels (i.e., intermittent 60% O2). Rats exposed to intermittent hyperoxia had smaller carotid bodies, and this morphological change may contribute to the blunted HVR. In contrast to rats exposed to intermittent hyperoxia beginning at birth, two weeks of intermittent 60% O2 had no effect on the HVR or carotid body size of rats exposed beginning at P28; therefore, intermittent hyperoxia-induced respiratory plasticity appears to be unique to development. Although both intermittent and sustained hyperoxia alter carotid body development and the HVR of rats, the specific effects and time course of this plasticity differs. Copyright © 2015 Elsevier B.V. All rights reserved.

  8. Intermittent hypoxia can aggravate motor neuronal loss and cognitive dysfunction in ALS mice.

    Directory of Open Access Journals (Sweden)

    Sung-Min Kim

    Full Text Available Patients with ALS may be exposed to variable degrees of chronic intermittent hypoxia. However, all previous experimental studies on the effects of hypoxia in ALS have only used a sustained hypoxia model and it is possible that chronic intermittent hypoxia exerts effects via a different molecular mechanism from that of sustained hypoxia. No study has yet shown that hypoxia (either chronic intermittent or sustained can affect the loss of motor neurons or cognitive function in an in vivo model of ALS.To evaluate the effects of chronic intermittent hypoxia on motor and cognitive function in ALS mice.Sixteen ALS mice and 16 wild-type mice were divided into 2 groups and subjected to either chronic intermittent hypoxia or normoxia for 2 weeks. The effects of chronic intermittent hypoxia on ALS mice were evaluated using the rotarod, Y-maze, and wire-hanging tests. In addition, numbers of motor neurons in the ventral horn of the spinal cord were counted and western blot analyses were performed for markers of oxidative stress and inflammatory pathway activation.Compared to ALS mice kept in normoxic conditions, ALS mice that experienced chronic intermittent hypoxia had poorer motor learning on the rotarod test, poorer spatial memory on the Y-maze test, shorter wire hanging time, and fewer motor neurons in the ventral spinal cord. Compared to ALS-normoxic and wild-type mice, ALS mice that experienced chronic intermittent hypoxia had higher levels of oxidative stress and inflammation.Chronic intermittent hypoxia can aggravate motor neuronal death, neuromuscular weakness, and probably cognitive dysfunction in ALS mice. The generation of oxidative stress with activation of inflammatory pathways may be associated with this mechanism. Our study will provide insight into the association of hypoxia with disease progression, and in turn, the rationale for an early non-invasive ventilation treatment in patients with ALS.

  9. Ocular torsion among patients with intermittent exotropia: relationships with disease severity factors.

    Science.gov (United States)

    Shin, Kwang Hoon; Lee, Hye Jin; Lim, Hyun Taek

    2013-01-01

    To investigate the distribution of ocular torsion in patients with intermittent exotropia and to determine possible correlation between the torsion and the severity of intermittent exotropia. Prospective, comparative study comprising 600 eyes of 300 children. One hundred fifty patients with intermittent exotropia between 4 and 15 years of age and another 150 age-matched normal controls without strabismus were enrolled prospectively. Digital nonmydriatic fundus photographs were obtained from both eyes of each subject and the disc-foveal angle was calculated using digital image software. All photographs also were graded as normal, extorsion, or intorsion. We compared the size of the disc-foveal angle between the normal and intermittent exotropia group. We analyzed possible correlations between the disc-foveal angle and disease severity factors, including amount of exotropia, Titmus stereoacuity, and duration of strabismus. Mean disc-foveal angle of intermittent exotropia group was significantly larger than that of normal control group (6.13 and 5.13 degrees, respectively; P extorsion or intorsion) was discovered in 45 (30%) patients among the intermittent exotropia group, whereas it was found in only 16 (11%) individuals among the normal control group (P < .01). The size of disc-foveal angle showed significant positive correlations with the amount of exotropia and the degree of stereoacuity (r = 0.45, P < .01, and r = 0.51, P < .01, respectively). Ocular torsion could be found not infrequently in patients with intermittent exotropia. Furthermore, the amount of torsion showed a significant relationship to the disease severity of intermittent exotropia. Assessment of ocular torsion could be used as a supplementary tool for evaluating fusion in patients with intermittent exotropia. Copyright © 2013 Elsevier Inc. All rights reserved.

  10. Clinical study of intermittent lock of the temporomandibular joint. Relation to frequency of intermittent lock on clinical examination and magnetic resonance imaging

    Energy Technology Data Exchange (ETDEWEB)

    Ide, Takashi; Nagai, Itaru; Miyazaki, Akihiro; Yamaguchi, Akira; Kohama, Geniku [Sapporo Medical Univ. (Japan). School of Medicine

    2002-03-01

    To examine the occurrence of intermittent lock, we investigated the correlation between the frequency of intermittent lock of the temporomandibular joint and magnetic resonance imaging (MRI) findings. The subjects consisted of 25 patients (25 joints) with unilateral intermittent lock who were treated from April 1994 through March 2000 at our department. MRI examination of the joint was performed on the affected side. We divided the patients into two groups: a high-frequency group consisting of 15 patients who had symptoms of intermittent lock every day and a low-frequency group consisting of 10 patients who did not have symptoms every day. The results showed no statistical difference between the two groups in clinical findings such as age, sex, clicking side of the joint, duration of intermittent lock, method of unlocking, muscle pain on palpation, degree of maximal mouth opening, distance between the maxillary and mandibular tooth midline, or the degree of overbite and overjet. However, the two groups differed significantly in the degree of anterior disc displacement as assessed by MRI. (author)

  11. Muscle involvement during intermittent contraction patterns with different target force feedback modes

    DEFF Research Database (Denmark)

    Sjøgaard, G; Jørgensen, L V; Ekner, D

    2000-01-01

    and following 30 min of intermittent contractions showed larger fatigue development with proprioceptive feedback than visual feedback. Also rating of perceived exertion increased more during proprioceptive feedback than visual feedback. This may in part be explained by small differences in the mechanics during......: Feedback mode significantly effects the muscle involvement and fatigue during intermittent contractions. RelevanceIntermittent contractions are common in many work places and various feedback modes are being given regarding work requirements. The choice of feedback may significantly affect the muscle load...... and consequently the development muscle fatigue and disorders....

  12. The problem of intermittency of renewable energies: solar and wind energy

    International Nuclear Information System (INIS)

    Livet, Frederic

    2011-01-01

    As solar and wind energies are to be intensively developed but are intermittent, more or less regular and unpredictable, the author first discusses methods which are presently used to manage this intermittency in various European countries. He also discusses the various methods which are proposed to compensate this intermittency: hydraulic storage, hydrogen-based storage, batteries, and large scale interconnections. He gives and comments cost assessments of the various proposed methods and of capacities. He shows that various measures which are discussed at the European level to promote renewable energies and to promote electricity exchanges will in fact result in a three times higher price of electricity for individuals

  13. Intermittent Misfiring Default Detection and Localisation on a PWM Inverter Using Wavelet Decomposition

    Directory of Open Access Journals (Sweden)

    H. Ben Attia Sethom

    2008-06-01

    Full Text Available This paper presents a method to detect and localize intermittent misfiring default on a Pulse Width Modulation (PWM inverter supplying a squirrel cage induction machine. The proposed method is based on the Discrete Wavelet Transform (DWT technique to analyse stator current signals. The intermittent misfiring detection is performed thanks to the Daubechies wavelet mother in high frequency bands of the stator current signal. The localisation of the phase where the intermittent misfiring occurs is determined by a statistic approach. This approach is based on the computing of mean power characteristics of the detail signals which are obtained from the stator current wavelet decomposition.

  14. Intermittently chaotic oscillations for a differential-delay equation with Gaussian nonlinearity

    Science.gov (United States)

    Hamilton, Ian

    1992-01-01

    For a differential-delay equation the time dependence of the variable is a function of the variable at a previous time. We consider a differential-delay equation with Gaussian nonlinearity that displays intermittent chaos. Although not the first example of a differential-delay equation that displays such behavior, for this example the intermittency is classified as type III, and the origin of the intermittent chaos may be qualitatively understood from the limiting forms of the equation for large and small variable magnitudes.

  15. Intermittent prophylaxis of recurrent febrile seizures with clobazam versus diazepam.

    Science.gov (United States)

    Sattar, S; Saha, S K; Parveen, F; Banu, L A; Momen, A; Ahmed, A U; Quddush, M R; Karim, M M; Begum, S A; Haque, M A; Hoque, M R

    2014-10-01

    Febrile seizures are the most common type of seizure among children that can be prevented by using prophylactic drugs like Clobazam and Diazepam. The present prospective study was conducted in the Department of Pediatrics, Mymensingh Medical College Hospital and Community Based Medical College Hospital, Bangladesh over a period of 1 year from July 2012 to June 2013 to compare the effectiveness of intermittent Clobazam versus Diazepam therapy in preventing the recurrence of febrile seizures and assessed adverse effects of each drug. A total of 65 patients (32 children administered Clobazam and rest 33 children received Diazepam) of simple and complex febrile seizures aged 6 months to 5 years of both sexes were the study population. Data were collected by interview of the patients, clinical examination and laboratory investigations using the research instrument. Data were analyzed by using Chi-square (χ2) Test, Student's 't' Test and Fisher's Exact Test. For all analytical tests, the level of significance was set at 0.05 and pDiazepam groups. Over 31% of patients in Clobazam group who experienced episode of fever within 3 months, 40.6% within 6 months and 9.4% within 9 months compared to 36.4% in Diazepam group within 3 months, 45.5% within 6 months & 12.1% within 9 months after discharge from the hospital. Three (9.4%) patients in Clobazam group and 7(21.3%) in Diazepam group who experienced febrile convulsion during the follow up period. From the data adverse effects within 3 and 6 months experienced by the patient's drowsiness, sedation and ataxia were higher in Diazepam group than those in Clobazam group. However, within 9 months lethargy and irritability were somewhat higher in Clobazam group than those in Diazepam group. The mean duration of hospitalization was significantly higher in Diazepam group compared to Clobazam group (6.0±1.0 vs. 4.6±0.08 days, PDiazepam group had a history of recurrent seizures, whereas 3(9.4%) of 32 children in the Clobazam group

  16. Water quality improvement of treated wastewater by intermittent soil percolation.

    Science.gov (United States)

    Castillo, G; Mena, M P; Dibarrart, F; Honeyman, G

    2001-01-01

    Our research aimed to evaluate intermittent soil infiltration of treated sewage for reuse in the north of Chile. Aerated lagoon effluent was infiltrated in columns packed with native soils (sandy-lime, lime-gravel and limey-sand). Columns were operated for more than a year under different cycles of filling and drying, depths and load pressures depending on soil characteristics. The efficiency of the system was determined through influent-effluent microbiological indicators level (faecal coliforms, E. coli, Salmonella spp, MS2 phage, and protozoan cysts), physicochemical characterisation (TOC, COD, BOD, nitrogen), and hydraulic flow measurement. Results showed: (a) high reduction of enteric bacteria (5-7 log10), some inactivation of phage (2-4 log10) and complete removal of intestinal cyst; (b) stable removal of organic matter (80-90% reduction of TOC, COD, BOD); and (c) partial ammonia reduction through adsorption and nitrification with denitrification mainly occurring in sandy soil. Preliminary data from pilot plant working in the field showed better results that those obtained in the laboratory especially removal of microbiological indicators. Microbiological quality of effluent met Class A regulations for agricultural reuse (WHO, 1989) and the system looks like an attractive alternative to cope with water shortage in the region.

  17. Amygdala hyperactivation to angry faces in intermittent explosive disorder.

    Science.gov (United States)

    McCloskey, Michael S; Phan, K Luan; Angstadt, Mike; Fettich, Karla C; Keedy, Sarah; Coccaro, Emil F

    2016-08-01

    Individuals with intermittent explosive disorder (IED) were previously found to exhibit amygdala hyperactivation and relatively reduced orbital medial prefrontal cortex (OMPFC) activation to angry faces while performing an implicit emotion information processing task during functional magnetic resonance imaging (fMRI). This study examines the neural substrates associated with explicit encoding of facial emotions among individuals with IED. Twenty unmedicated IED subjects and twenty healthy, matched comparison subjects (HC) underwent fMRI while viewing blocks of angry, happy, and neutral faces and identifying the emotional valence of each face (positive, negative or neutral). We compared amygdala and OMPFC reactivity to faces between IED and HC subjects. We also examined the relationship between amygdala/OMPFC activation and aggression severity. Compared to controls, the IED group exhibited greater amygdala response to angry (vs. neutral) facial expressions. In contrast, IED and control groups did not differ in OMPFC activation to angry faces. Across subjects amygdala activation to angry faces was correlated with number of prior aggressive acts. These findings extend previous evidence of amygdala dysfunction in response to the identification of an ecologically-valid social threat signal (processing angry faces) among individuals with IED, further substantiating a link between amygdala hyperactivity to social signals of direct threat and aggression. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. Intermittent Coronal Loop Oscillations by Random Energy Releases

    Science.gov (United States)

    Mendoza-Briceño, César A.; Erdélyi, Robert

    2006-09-01

    High-resolution observations by the SOHO and TRACE spacecraft have confirmed the existence of coronal loop oscillations and waves. In a recent work, Mendoza-Briceño et al. studied the heating response of coronal plasma to energy pulses randomly distributed in time and space along coronal loops. In this paper we focus on the oscillatory patterns and other features, such as cool gas blobs traveling along the loop, during the evolution of spatiotemporal randomly heated flux tubes in the corona. The nature of these oscillatory patterns is investigated using wavelet analysis. Periodic features, such as wave packets, with periods of 150-220, 500-600, and 800-1000 s are found. It is also found that the periods increase with the loop length and decrease with the length of the loop segments along which the pulses are injected. On the other hand, the randomly driven intermittent cool plasma blobs that propagate from one footpoint to the other are analyzed. Although plenty of coronal loop oscillations are detected by the cohort of the current high-resolution satellites, there are more controversial observational evidences about the predicted cold plasma blobs.

  19. Movement mechanisms of gross solids in intermittent flow.

    Science.gov (United States)

    Littlewood, K; Butler, D

    2003-01-01

    Gross solids, such as used tampons, sanitary towels and faecal stools, are introduced into the sewer network via the WC. Although small diameter pipes (< or = 150mm diameter) make up a large proportion of most sewer networks, the transport behaviour of gross solids in these smaller pipes is not fully established. In particular, there are concerns about the effect of water conservation measures on the transport of gross solids in the intermittent flow regime prevalent in small pipes. This paper introduces a study carried out on the movement of solids in this flow regime. An extensive series of experiments has been carried out to investigate the movement mechanisms and behaviour in detail. It was found that there are three different mechanisms of movement, and photographic evidence is provided in the paper. The concept and implications of the "limiting solid transport distance" is also introduced. It is argued that solid movement is dependent on factors other than just WC flush volume and that increased blockage potential is not inevitable.

  20. Sustainable integration of high levels of intermittent generation

    International Nuclear Information System (INIS)

    Pereira, R.; Cabral, P.

    2005-01-01

    The sustainable development of electric power systems rely on three main drivers: the security of supply, the competitiveness and the protection of the environment. For this purpose the promotion of endogenous energy sources, mainly the renewable ones, should be underlined. Still, most of renewable energy sources raise very sensitive issues concerning the security of supply, due to its randomness and unpredictability. The wind power, currently in its fast growing development, plays a relevant role on this matter. From the demand-side perspective, there is also a lot to do regarding the promotion of more efficient use of energy as well as mechanisms that contribute to security of supply. This paper aims to present guidelines for the selection of the most adequate solutions regarding: sustainable evolution of renewable generation technologies, based on the most meritorious resources under economic and security of supply assessments; complementary energy storage systems that allow the integration of intermittent generation ensuring adequate security of supply levels; and sustainable evolution of demand, based on DSM measures selected from different available alternatives. (author)

  1. The experience of aggressive outbursts in Intermittent Explosive Disorder.

    Science.gov (United States)

    Kulper, Daniel A; Kleiman, Evan M; McCloskey, Michael S; Berman, Mitchell E; Coccaro, Emil F

    2015-02-28

    Conceptualizations of Intermittent Explosive Disorder (IED) have suffered from a scarcity of research investigating the subjective experience and phenomenology of the aggressive outbursts among those with IED relative to those who partake in more normative forms of aggression. Furthermore, though some studies have shown that individuals with IED are more impaired and have a poorer quality of life, few studies looked at negative outcomes specific to an individual with IED׳s aggressive behavior. The purpose of this study was to examine the subjective experience and social, occupational, and legal consequences of aggressive outbursts in IED. We assessed individuals with IED (n=410), psychiatric controls (n=133), and healthy controls (HC) (n=154) in the experiential correlates present before, during, and after an aggressive outburst as well as the consequences of aggressive outbursts. Results indicated that before and during aggressive outbursts, individuals with IED experienced more intense anger, physiological reactivity, and feelings of dyscontrol as well as more remorse after an aggressive outburst. Furthermore, individuals with IED report more negative consequences of their aggressive outbursts. These results provide an account of how the subjective experience and consequences of aggressive outbursts in IED differ from those with more normative forms of aggression. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  2. Supporting the externality of intermittency in policies for renewable energy

    International Nuclear Information System (INIS)

    Bunn, Derek W.; Muñoz, José I.

    2016-01-01

    We analyse the joint problem of supporting renewables and resource adequacy in a liberalised electricity market and present a detailed model-based comparison of two alternative policies. We undertake this in the context of the British market. We show how, ceteris paribus, the progressive replacement of coal with wind imposes extra costs of reserve and evaluate alternative way to meet this, whether through capacity payments funded by customers, or a reliability requirement on wind generators with capital cost or energy feed-in subsidies. We consider the reality of market concentration and the extent to which pragmatic regulation could allow prices to rise above marginal cost to reduce the extent of direct subsidies and complex market designs. We also evaluate the implied cost of carbon reduction in a progressive replacement of coal with wind, when the security is maintained by extra peaking gas. We find that support through capital allowances rather than the energy market is more efficient. - Highlights: • Progressively replacing coal by offshore wind may require increasing subsidies. • Risk-averse investors seek higher financial hurdles with more intermittent technologies. • The externality of providing extra reserves should be bundled with the renewable subsidies. • Using capital grants rather than green certificates leads to lower costs.

  3. The polymorphic and contradictory aspects of intermittent hypoxia.

    Science.gov (United States)

    Almendros, Isaac; Wang, Yang; Gozal, David

    2014-07-15

    Intermittent hypoxia (IH) has been extensively studied during the last decade, primarily as a surrogate model of sleep apnea. However, IH is a much more pervasive phenomenon in human disease, is viewed as a potential therapeutic approach, and has also been used in other disciplines, such as in competitive sports. In this context, adverse outcomes involving cardiovascular, cognitive, metabolic, and cancer problems have emerged in obstructive sleep apnea-based studies, whereas beneficial effects of IH have also been identified. Those a priori contradictory findings may not be as contradictory as initially thought. Indeed, the opposite outcomes triggered by IH can be explained by the specific characteristics of the large diversity of IH patterns applied in each study. The balance between benefits and injury appears to primarily depend on the ability of the organism to respond and activate adaptive mechanisms to IH. In this context, the adaptive or maladaptive responses can be generally predicted by the frequency, severity, and duration of IH. However, the presence of underlying conditions such as hypertension or obesity, as well as age, sex, or genotypic variance, may be important factors tilting the balance between an appropriate homeostatic response and decompensation. Here, the two possible facets of IH as derived from human and experimental animal settings will be reviewed. Copyright © 2014 the American Physiological Society.

  4. Modelling of intermittent microwave convective drying: parameter sensitivity

    Directory of Open Access Journals (Sweden)

    Zhang Zhijun

    2017-06-01

    Full Text Available The reliability of the predictions of a mathematical model is a prerequisite to its utilization. A multiphase porous media model of intermittent microwave convective drying is developed based on the literature. The model considers the liquid water, gas and solid matrix inside of food. The model is simulated by COMSOL software. Its sensitivity parameter is analysed by changing the parameter values by ±20%, with the exception of several parameters. The sensitivity analysis of the process of the microwave power level shows that each parameter: ambient temperature, effective gas diffusivity, and evaporation rate constant, has significant effects on the process. However, the surface mass, heat transfer coefficient, relative and intrinsic permeability of the gas, and capillary diffusivity of water do not have a considerable effect. The evaporation rate constant has minimal parameter sensitivity with a ±20% value change, until it is changed 10-fold. In all results, the temperature and vapour pressure curves show the same trends as the moisture content curve. However, the water saturation at the medium surface and in the centre show different results. Vapour transfer is the major mass transfer phenomenon that affects the drying process.

  5. Arousal and continuous attention during Ramadan intermittent fasting.

    Science.gov (United States)

    Dolu, Nazan; Yüksek, Ahmet; Sizer, Alparslan; Alay, Mehmet

    2007-01-01

    During the month of Ramadan, practicing Muslims abstain from eating and drinking from sunrise to sunset. We aimed to investigate the effect of Ramadan fasting on arousal and continuous attention. The electrodermal activity and cancellation test of students were measured in fasting and non-fasting conditions after the conclusion of the Ramadan fast period. The skin conductance level of the fasting group was no different from the non-fasting group. In non-fasting group, the skin conductance response amplitude to an auditory stimulus was higher and the skin conductance response onset latency was lower than in the fasting group. Cancellation test results: the fasting group had a lower total number of marked targets (TNTM) but a higher total number of missed targets (TNMT) and length of time for the subject to complete the test (LTCT) than the non-fasting group. Ramadan fasting did not change arousal, but the reaction time to an auditory stimulus increased during the Ramadan intermittent fasting. Both reaction amplitude and continuous attention also decreased in the fasting condition.

  6. Intermittent hypercapnia enhances CO₂ responsiveness and overcomes serotonergic dysfunction.

    Science.gov (United States)

    Mosher, Bryan P; Taylor, Barbara E; Harris, Michael B

    2014-08-15

    Serotonergic dysfunction compromises ventilatory chemosensitivity and may enhance vulnerability to pathologies such as the Sudden Infant Death Syndrome (SIDS). We have shown raphé contributions to central chemosensitivity involving serotonin (5-HT)-and γ-aminobutyric acid (GABA)-mediated mechanisms. We tested the hypothesis that mild intermittent hypercapnia (IHc) induces respiratory plasticity, due in part to strengthening of GABA mechanisms. Rat pups were IHc-pretreated (eight consecutive cycles; 5 min 5% CO2 - air, 10 min air) or constant normocapnia-pretreated as a control, each day for 5 consecutive days beginning at P12. We subsequently assessed CO2 responsiveness using the in situ perfused brainstem preparation. Hypercapnic responses were determined with and without pharmacological manipulation. Results show IHc-pretreatment induces plasticity sufficient for responsiveness despite removal of otherwise critical ketanserin-sensitive mechanisms. Responsiveness following IHc-pretreatment was absent if ketanserin was combined with GABAergic antagonism, indicating that plasticity depends on GABAergic mechanisms. We propose that IHc-induced plasticity could reduce the severity of reflex dysfunctions underlying pathologies such as SIDS. Copyright © 2014 Elsevier B.V. All rights reserved.

  7. Nonvalue of Neomycin Instillation after Intermittent Urinary Catheterization

    Science.gov (United States)

    Haldorson, Alice M.; Keys, Thomas F.; Maker, Myron D.; Opitz, Joachim L.

    1978-01-01

    This study evaluated weekly urine cultures of patients with neurogenic bladder disease who underwent intermittent urinary catheterization for bladder retraining. One group of 53 patients in 1974 received regular instillations of 0.1% neomycin after each catheterization. A similar group of 55 patients in 1975 did not receive neomycin and constituted a control group. Distribution of age, sex, diagnosis, and duration of bladder retraining was comparable in both groups. Quantitative bacterial colony counts of 104 to 105 or greater per ml of urine were considered significant. There was no difference in the incidence of bacteriuria between the neomycin-treated group and the control group (53 versus 49%, respectively), and most patients in each group had colony counts >105/ml. Escherichia coli was seen less frequently in neomycin-treated patients (43.4 versus 62.5%), but a greater percentage of infections due to Pseudomonas aeruginosa, group D streptococci, and yeasts was noted in the neomycin-treated group than in the control group (41.5 versus 22.5%). PMID:360984

  8. Optimal Intermittent Dose Schedules for Chemotherapy Using Genetic Algorithm

    Directory of Open Access Journals (Sweden)

    Nadia ALAM

    2013-08-01

    Full Text Available In this paper, a design method for optimal cancer chemotherapy schedules via genetic algorithm (GA is presented. The design targets the key objective of chemotherapy to minimize the size of cancer tumor after a predefined time with keeping toxic side effects in limit. This is a difficult target to achieve using conventional clinical methods due to poor therapeutic indices of existing anti-cancer drugs. Moreover, there are clinical limitations in treatment administration to maintain continuous treatment. Besides, carefully decided rest periods are recommended to for patient’s comfort. Three intermittent drug scheduling schemes are presented in this paper where GA is used to optimize the dose quantities and timings by satisfying several treatment constraints. All three schemes are found to be effective in total elimination of cancer tumor after an agreed treatment length. The number of cancer cells is found zero at the end of the treatment for all three cases with tolerable toxicity. Finally, two of the schemes, “Fixed interval variable dose (FIVD and “Periodic dose” that are periodic in characteristic have been emphasized due to their additional simplicity in administration along with friendliness to patients. responses to the designed treatment schedules. Therefore the proposed design method is capable of planning effective, simple, patient friendly and acceptable chemotherapy schedules.

  9. Effects of intermittent fasting on metabolism in men.

    Science.gov (United States)

    Azevedo, Fernanda Reis de; Ikeoka, Dimas; Caramelli, Bruno

    2013-01-01

    This review analyzes the available literature on the impact of intermittent fasting (IF), a nutritional intervention, on different aspects of metabolism. The epidemic of metabolic disturbances, such as obesity, metabolic syndrome (MS), and diabetes mellitus type 2 has led to an increase in the prevalence of cardiovascular diseases, and affected patients might significantly benefit from modifications in nutritional habits. Recent experimental studies have elucidated some of the metabolic mechanisms involved with IF. Animal models have shown positive changes in glucose (lower plasma glucose and insulin levels) and in lipid metabolism (reduced visceral fat tissue and increased plasma adiponectin level), and an increased resistance to stress. Despite the limited number of samples studied, positive results have been reported on the impact of IF for human health. IF is reported to improve the lipid profile; to decrease inflammatory responses, reflected by changes in serum adipokine levels; and to change the expression of genes related to inflammatory response and other factors. Studies on obese individuals have shown that patient compliance was greater for IF than other traditional nutritional approaches (calorie restriction), and IF was found to be associated with low oxidative stress. Recent reports suggest that IF exerts a positive impact on the metabolic derangements commonly associated with cardiovascular diseases, and that it may be a viable and accessible intervention for most individuals. Therefore, further clinical studies are essential to test the effectiveness of IF in preventing and controlling metabolic and cardiovascular diseases. Copyright © 2013 Elsevier Editora Ltda. All rights reserved.

  10. Smoking patterns and stimulus control in intermittent and daily smokers.

    Directory of Open Access Journals (Sweden)

    Saul Shiffman

    Full Text Available Intermittent smokers (ITS - who smoke less than daily - comprise an increasing proportion of adult smokers. Their smoking patterns challenge theoretical models of smoking motivation, which emphasize regular and frequent smoking to maintain nicotine levels and avoid withdrawal, but yet have gone largely unexamined. We characterized smoking patterns among 212 ITS (smoking 4-27 days per month compared to 194 daily smokers (DS; smoking 5-30 cigarettes daily who monitored situational antecedents of smoking using ecological momentary assessment. Subjects recorded each cigarette on an electronic diary, and situational variables were assessed in a random subset (n=21,539 smoking episodes; parallel assessments were obtained by beeping subjects at random when they were not smoking (n=26,930 non-smoking occasions. Compared to DS, ITS' smoking was more strongly associated with being away from home, being in a bar, drinking alcohol, socializing, being with friends and acquaintances, and when others were smoking. Mood had only modest effects in either group. DS' and ITS' smoking were substantially and equally suppressed by smoking restrictions, although ITS more often cited self-imposed restrictions. ITS' smoking was consistently more associated with environmental cues and contexts, especially those associated with positive or "indulgent" smoking situations. Stimulus control may be an important influence in maintaining smoking and making quitting difficult among ITS.

  11. Efficient pricing and investment in electricity markets with intermittent resources

    International Nuclear Information System (INIS)

    Chao, Hung-po

    2011-01-01

    Facing growing technological and environmental challenges, the electricity industry needs effective pricing mechanism to promote efficient risk management and investment decisions. In a restructured electricity market with competitive wholesale prices and traditionally regulated retail rates, however, there are technical and institutional barriers that prevent dynamic pricing with price responsive demand. In regions with limited energy storage capacity, intermittent renewable resources present special challenges. This could adversely affect the effectiveness of public policies causing inefficient investments in energy technologies. In this paper, we present an updated economic model of pricing and investment in restructured electricity market and use the model in a simulation study for an initial assessment of renewable energy strategy and alternative pricing mechanisms. A key objective of the study is to shed light on the policy issues so that effective decisions can be made to improve efficiency. - Highlights: → Renewable resources present special challenges in regions with limited energy storage capacity. → This paper presents an updated economic model of pricing and investment in restructured electricity market. → A simulation study assesses renewable energy strategy and alternative pricing mechanisms. → The study results inform policy decisions to improve efficient investments in energy technologies.

  12. Top predator absence enhances leaf breakdown in an intermittent stream.

    Science.gov (United States)

    Rodríguez-Lozano, Pablo; Rieradevall, Maria; Prat, Narcís

    2016-12-01

    Current biodiversity loss is characterized by the extinction of top predators, but small-bodied freshwater fish are often overlooked in research and conservation management even when threatened because they usually lack commercial value. Therefore, the ecosystem impacts of their possible loss remain mostly unknown. We assessed whether the presence/absence of an endangered predatory fish (Barbus meridionalis (A. Risso, 1827)) in an intermittent stream affects leaf fungal biomass and leaf quality (i.e. leaf carbon:nitrogen ratio and leaf toughness), macroinvertebrate assemblages colonizing leaf packs, and leaf breakdown rates. We conducted a leaf bag experiment comparing a control reach with a population of B. meridionalis with an adjacent upstream fishless reach. In the fishless reach, leaf fungal biomass and microbially mediated breakdown rate were lower compared to the control reach. This was probably caused by the lack of the bottom-up stimulation through nutrient recycling by fish. Shredders and scrapers were found at higher abundance and biomass in the fishless compared to the control reach, and the whole macroinvertebrate community composition changed with fish absence. Consequently, macroinvertebrate mediated leaf breakdown was faster in the fishless than in the control reach, not only compensating for the lower microbially mediated leaf breakdown in the fishless reach, but accelerating the overall leaf breakdown rate. Our study contributes to understand the potential cascading effects produced by the extirpation of endangered small-bodied fish. Copyright © 2016 Elsevier B.V. All rights reserved.

  13. Intermittent Brugada Syndrome Presenting with Syncope in an Adult Female

    Directory of Open Access Journals (Sweden)

    Patricia Chavez

    2014-01-01

    Full Text Available Background. Brugada syndrome accounts for 4–12% of all sudden deaths worldwide and at least 20% of sudden deaths in patients with structurally normal hearts. Case Report. A 48-year-old female presented to the emergency department after two witnessed syncopal episodes. While awaiting discharge had a third collapse followed by cardiac arrest with shockable rhythm. Initial electrocardiogram showed wide QRS complex with left axis deviation, ST-segment elevation of 2 mm followed by a negative T wave with no isoelectric separation, suggestive of spontaneous intermittent Brugada type 1 pattern. Cardiac magnetic resonance imaging demonstrated neither structural heart disease nor abnormal myocardium. After placement of an implantable cardioverter defibrillator the patient was discharged. Why should an emergency physician be aware of this? Brugada syndrome is an infrequently encountered clinical entity which may have a fatal outcome. This syndrome primarily presents with syncope. It should be considered as a component of differential diagnosis in patients with family history of syncope and sudden cardiac death.

  14. Intermittent Flow In Yield Stress Fluids Slows Down Chaotic Mixing

    Science.gov (United States)

    Boujlel, Jalila; Wendell, Dawn; Gouillart, Emmanuelle; Pigeonneau, Franck; Jop, Pierre; Laboratoire Surface du Verre et Interfaces Team

    2013-11-01

    Many mixing situations involve fluids with non-Newtonian properties: mixing of building materials such as concrete or mortar are based on fluids that have shear- thinning rheological properties. Lack of correct mixing can waste time and money, or lead to products with defects. When fluids are stirred and mixed together at low Reynolds number, the fluid particles should undergo chaotic trajectories to be well mixed by the so-called chaotic advection resulting from the flow. Previous work to characterize chaotic mixing in many different geometries has primarily focused on Newtonian fluids. First studies into non-Newtonian chaotic advection often utilize idealized mixing geometries such as cavity flows or journal bearing flows for numerical studies. Here, we present experimental results of chaotic mixing of yield stress fluids with non-Newtonian fluids using rod-stirring protocol with rotating vessel. We describe the various steps of the mixing and determine their dependence on the fluid rheology and speeds of rotation of the rods and the vessel. We show how the mixing of yield-stress fluids by chaotic advection is reduced compared to the mixing of Newtonian fluids and explain our results, bringing to light the relevant mechanisms: the presence of fluid that only flows intermittently, a phenomenon enhanced by the yield stress, and the importance of the peripheral region. This result is confirmed via numerical simulations.

  15. Modelling of intermittent microwave convective drying: parameter sensitivity

    Science.gov (United States)

    Zhang, Zhijun; Qin, Wenchao; Shi, Bin; Gao, Jingxin; Zhang, Shiwei

    2017-06-01

    The reliability of the predictions of a mathematical model is a prerequisite to its utilization. A multiphase porous media model of intermittent microwave convective drying is developed based on the literature. The model considers the liquid water, gas and solid matrix inside of food. The model is simulated by COMSOL software. Its sensitivity parameter is analysed by changing the parameter values by ±20%, with the exception of several parameters. The sensitivity analysis of the process of the microwave power level shows that each parameter: ambient temperature, effective gas diffusivity, and evaporation rate constant, has significant effects on the process. However, the surface mass, heat transfer coefficient, relative and intrinsic permeability of the gas, and capillary diffusivity of water do not have a considerable effect. The evaporation rate constant has minimal parameter sensitivity with a ±20% value change, until it is changed 10-fold. In all results, the temperature and vapour pressure curves show the same trends as the moisture content curve. However, the water saturation at the medium surface and in the centre show different results. Vapour transfer is the major mass transfer phenomenon that affects the drying process.

  16. A stochastic space-time model for intermittent precipitation occurrences

    KAUST Repository

    Sun, Ying

    2016-01-28

    Modeling a precipitation field is challenging due to its intermittent and highly scale-dependent nature. Motivated by the features of high-frequency precipitation data from a network of rain gauges, we propose a threshold space-time t random field (tRF) model for 15-minute precipitation occurrences. This model is constructed through a space-time Gaussian random field (GRF) with random scaling varying along time or space and time. It can be viewed as a generalization of the purely spatial tRF, and has a hierarchical representation that allows for Bayesian interpretation. Developing appropriate tools for evaluating precipitation models is a crucial part of the model-building process, and we focus on evaluating whether models can produce the observed conditional dry and rain probabilities given that some set of neighboring sites all have rain or all have no rain. These conditional probabilities show that the proposed space-time model has noticeable improvements in some characteristics of joint rainfall occurrences for the data we have considered.

  17. Smoking Patterns and Stimulus Control in Intermittent and Daily Smokers

    Science.gov (United States)

    Shiffman, Saul; Dunbar, Michael S.; Li, Xiaoxue; Scholl, Sarah M.; Tindle, Hilary A.; Anderson, Stewart J.; Ferguson, Stuart G.

    2014-01-01

    Intermittent smokers (ITS) – who smoke less than daily – comprise an increasing proportion of adult smokers. Their smoking patterns challenge theoretical models of smoking motivation, which emphasize regular and frequent smoking to maintain nicotine levels and avoid withdrawal, but yet have gone largely unexamined. We characterized smoking patterns among 212 ITS (smoking 4–27 days per month) compared to 194 daily smokers (DS; smoking 5–30 cigarettes daily) who monitored situational antecedents of smoking using ecological momentary assessment. Subjects recorded each cigarette on an electronic diary, and situational variables were assessed in a random subset (n = 21,539 smoking episodes); parallel assessments were obtained by beeping subjects at random when they were not smoking (n = 26,930 non-smoking occasions). Compared to DS, ITS' smoking was more strongly associated with being away from home, being in a bar, drinking alcohol, socializing, being with friends and acquaintances, and when others were smoking. Mood had only modest effects in either group. DS' and ITS' smoking were substantially and equally suppressed by smoking restrictions, although ITS more often cited self-imposed restrictions. ITS' smoking was consistently more associated with environmental cues and contexts, especially those associated with positive or “indulgent” smoking situations. Stimulus control may be an important influence in maintaining smoking and making quitting difficult among ITS. PMID:24599056

  18. Functional independence measure in patients with intermittent claudication

    Directory of Open Access Journals (Sweden)

    Caroline Shihara de Assis

    2015-10-01

    Full Text Available AbstractOBJECTIVEOf this study were to evaluate the functional independence of patients with intermittent claudication and to verify its association with sociodemographic and clinical variables, walking ability and physical activity level.METHODThis was a descriptive, exploratory, cross-sectional study with a quantitative approach. Fifty participants (66.4 years; 68% male were recruited from Claudication Unit of a tertiary hospital. Functional Independence Measure were used to evaluate functional incapacity; the Baltimore Activity Scale, to estimate the physical activity level and the Walking Impairement Questionnaire, the walking ability.RESULTSParticipants had complete functional independence (124.8 + 2.0, low levels of physical activity (4.2 + 2.0, and impairment of walking ability; the worst performance was found in walking velocity domain (21.2 + 16.4. The functional independence score was associated with physical activity (r=0,402 and walking ability scores (distance, r=0,485; speed, r=0,463; stairs, r=0,337.CONCLUSIONIn conclusion, the level of functionality is associated with functional capacity in these patients.

  19. Assimilating uncertain, dynamic and intermittent streamflow observations in hydrological models

    Science.gov (United States)

    Mazzoleni, Maurizio; Alfonso, Leonardo; Chacon-Hurtado, Juan; Solomatine, Dimitri

    2015-09-01

    Catastrophic floods cause significant socio-economical losses. Non-structural measures, such as real-time flood forecasting, can potentially reduce flood risk. To this end, data assimilation methods have been used to improve flood forecasts by integrating static ground observations, and in some cases also remote sensing observations, within water models. Current hydrologic and hydraulic research works consider assimilation of observations coming from traditional, static sensors. At the same time, low-cost, mobile sensors and mobile communication devices are becoming also increasingly available. The main goal and innovation of this study is to demonstrate the usefulness of assimilating uncertain streamflow observations that are dynamic in space and intermittent in time in the context of two different semi-distributed hydrological model structures. The developed method is applied to the Brue basin, where the dynamic observations are imitated by the synthetic observations of discharge. The results of this study show how model structures and sensors locations affect in different ways the assimilation of streamflow observations. In addition, it proves how assimilation of such uncertain observations from dynamic sensors can provide model improvements similar to those of streamflow observations coming from a non-optimal network of static physical sensors. This can be a potential application of recent efforts to build citizen observatories of water, which can make the citizens an active part in information capturing, evaluation and communication, helping simultaneously to improvement of model-based flood forecasting.

  20. Observations and Models of Highly Intermittent Phytoplankton Distributions

    Science.gov (United States)

    Mandal, Sandip; Locke, Christopher; Tanaka, Mamoru; Yamazaki, Hidekatsu

    2014-01-01

    The measurement of phytoplankton distributions in ocean ecosystems provides the basis for elucidating the influences of physical processes on plankton dynamics. Technological advances allow for measurement of phytoplankton data to greater resolution, displaying high spatial variability. In conventional mathematical models, the mean value of the measured variable is approximated to compare with the model output, which may misinterpret the reality of planktonic ecosystems, especially at the microscale level. To consider intermittency of variables, in this work, a new modelling approach to the planktonic ecosystem is applied, called the closure approach. Using this approach for a simple nutrient-phytoplankton model, we have shown how consideration of the fluctuating parts of model variables can affect system dynamics. Also, we have found a critical value of variance of overall fluctuating terms below which the conventional non-closure model and the mean value from the closure model exhibit the same result. This analysis gives an idea about the importance of the fluctuating parts of model variables and about when to use the closure approach. Comparisons of plot of mean versus standard deviation of phytoplankton at different depths, obtained using this new approach with real observations, give this approach good conformity. PMID:24787740

  1. Intermittent hemodialysis in dogs with chronic kidney disease stage III

    Directory of Open Access Journals (Sweden)

    Alessandra Melchert

    2017-08-01

    Full Text Available ABSTRACT: Intermittent hemodialysis (IHD is a form of renal replacement that is used in veterinary medicine for cases involving drug removal, electrolyte imbalance, acute kidney injury, and chronic kidney disease (CKD. The aim of the present study was to verify the efficacy of IHD in dogs with CKD staged at grade III and to evaluate the effect of IHD on quality of life. Twelve dogs with CKD at stage III met the inclusion criteria and were divided equally into two groups. The control group (n=6 received only clinical treatment and intravenous fluid therapy, and the hemodialysis group (n=6 received clinical and IHD treatments. Blood samples were collected before and after treatments in both groups. We evaluated complications and clinical parameters of IHD every 30 minutes. Hemodialysis decreased serum urea, creatinine, and phosphorus. Despite the evident removal of nitrogen compounds, dialysis treatment did not increase survival time in these patients. The results of this study do not support the early use of dialysis in dogs with chronic kidney disease stage III.

  2. External pneumatic intermittent compression for treatment of dependent pregnancy edema.

    Science.gov (United States)

    Jacobs, M K; McCance, K L; Stewart, M L

    1982-01-01

    A portable external pneumatic intermittent compression (EPIC) device has been successful in reducing peripheral edema. This study explored the effectiveness of EPIC for treating dependent pregnancy edema. In the study, 42 healthy pregnant women received EPIC for 30 minutes at 40 torr while in the left lateral recumbent position: Group One with mid-thigh boots, and Group Two with below-knee boots. Prior to compression, descriptive data were gathered, leg circumference measurements made, and surface skin temperatures recorded for three sites per leg. Vital signs were taken and pedal edema subjectively indexed. Following compression, circumferences, skin temperatures, vital signs, and edema indices were rerecorded. Three volumes were calculated for each leg using a mathematical model of leg segments as conical frustum units. Mean volume reductions for each leg were significant. The mid-thigh-length boots produced greater mean volume decreases. The volume decrease for calf, lower leg, and foot frustum units were significant. EPIC holds promise as a useful treatment for dependent pregnancy edema.

  3. Intermittent hypoxic resistance training: is metabolic stress the key moderator?

    Science.gov (United States)

    Scott, Brendan R; Slattery, Katie M; Dascombe, Ben J

    2015-02-01

    Traditionally, researchers and practitioners have manipulated acute resistance exercise variables to elicit the desired responses to training. However, recent research indicates that altering the muscular environment during resistance training, namely by implementing a hypoxic stimulus, can augment muscle hypertrophy and strength. Intermittent hypoxic resistance training (IHRT), whereby participants inspire hypoxic air during resistance training, has been previously demonstrated to increase muscle cross-sectional area and maximum strength by significantly greater amounts than the equivalent training in normoxia. However, some recent evidence has provided conflicting results, reporting that the use of systemic hypoxia during resistance training provided no added benefit. While the definitive mechanisms that may augment muscular responses to IHRT are not yet fully understood, an increased metabolic stress is thought to be important for moderating many downstream processes related to hypertrophy. It is likely that methodological differences between conflicting IHRT studies have resulted in different degrees of metabolic stress during training, particularly when considering the inter-set recovery intervals used. Given that the most fundamental physiological stresses resulting from hypoxia are disturbances to oxidative metabolism, it becomes apparent that resistance training may only benefit from additional hypoxia if the exercise is structured to elicit a strong metabolic response. We hypothesize that for IHRT to be more effective in producing muscular hypertrophy and increasing strength than the equivalent normoxic training, exercise should be performed with relatively brief inter-set recovery periods, with the aim of providing a potent metabolic stimulus to enhance anabolic responses. Copyright © 2014 Elsevier Ltd. All rights reserved.

  4. The Yo-Yo intermittent recovery test in basketball players.

    Science.gov (United States)

    Castagna, Carlo; Impellizzeri, Franco M; Rampinini, Ermanno; D'Ottavio, Stefano; Manzi, Vincenzo

    2008-04-01

    The purpose of this study was to examine the physiological correlates of the Yo-Yo intermittent recovery test level 1 (Yo-Yo IR1) in basketball players. Twenty-two male basketball players (means+/-S.D., body mass 72.4+/-11.4kg, height 181.7+/-6.9cm, age 16.8+/-2.0 years) were tested for maximal oxygen uptake (VO(2max)), ventilatory threshold (VT) and running economy (RE) on a motorized treadmill. Lower limb explosive strength and anaerobic-capacity was assessed using vertical jumps (CMJ), 15m shuttle running sprint (15mSR) and line drill (LD), respectively. The same test battery was replicated after an experimental basketball game in order to assess selective effect of fatigue on physical performance. Pre to post-game CMJ (40.3+/-5.7 versus 39.9+/-5.9cm) and 15mSR (5.80+/-0.25 versus 5.77+/-0.22s) performances were not significantly different (p>0.05). LD performance decreased significantly post-game (from 26.7+/-1.3 to 27.7+/-2.7s, pbasketball-specific test for the assessment of aerobic fitness and game-related endurance.

  5. Intermittent Oral Versus Intravenous Alfacalcidol in Dialysis Patients

    Directory of Open Access Journals (Sweden)

    Mitwalli Ahmed

    2000-01-01

    Full Text Available Patients with end-stage renal failure (ESRF on maintenance dialysis, commonly develop secondary hyperparathyroidism and renal osteodystrophy (ROD. Alfacalcidol, taken orally or administered intravenously, is known to reverse these complications. In this study, 19 ESRF patients, who were on dialysis (13 on hemodialysis and six on peritoneal dialysis for longer than six months and having serum parathormone levels at least four times normal and serum calcium less than 2.1 mmol/L, were randomly allocated to treatment with oral or intravenous (i.v. alfacalcidol for a period of 12 months. There were six patients on hemodialysis (HD and three on peritoneal dialysis (PD in the oral treatment group while in the i.v. group there were seven patients on HD and three on PD. Clinical and serial biochemical assessments showed no statistically significant difference between the orally- and i.v.-treated patients in terms of suppressing secondary hyperparathyroidism and osteodystrophy. However, patients with features of mild ROD on bone histology, had more satisfactory changes in biochemistry when compared to others. Our results further support the use of intermittent oral alfacalcidol in ESRF patients because of its cost effectiveness, ease of administration and convenience, especially for peritoneal dialysis patients.

  6. The Effect of Intermittent Noise Stress on Ozone-Induced ...

    Science.gov (United States)

    Previous studies have established that acute exposure to air pollution increases the risk of cardiovascular dysfunction. Intrinsic factors are likely the most important determinants of how the body responds to an exposure. But data also suggests that non-environmental stressors like noise, which is a common urban public health problem, can modify and indeed worsen the response. Noise can cause obvious psychological disturbances typical of non-specific stress, but also changes that can increase the number of cardiovascular disease related mortalities. Therefore, we hypothesized that short-term exposure to noise would worsen the cardiovascular response to ozone. Male Wistar-Kyoto rats were implanted with radiotelemeters for the measurement of heart rate (HR), blood pressure (BP) and electrocardiogram (ECG) and exposed to intermittent noise (85-90 dB) for one week after which they were exposed to either ozone (0.8 ppm) or filtered air. Left ventricular functional responses to dobutamine were measured using a Millar probe as well as arrhythmic sensitivity to aconitine in a separate set of untelemetered rats 24 hours after exposure. HR and BP decreased in all telemetered animals during ozone exposure; noise caused BP and HR to increase. Baseline left ventricular pressure (LVP) was significantly higher in animals exposed to both noise and ozone when compared to no noise; furthermore those animals had the least amount of change in LVP, dP/dT max and min with increasi

  7. Commercial and Industrial Base Intermittent Resource Management Pilot

    Energy Technology Data Exchange (ETDEWEB)

    Kiliccote, Sila; Sporborg, Pamela; Sheik, Imran; Huffaker, Erich; Piette, Mary Ann

    2010-11-30

    This scoping study summarizes the challenges with integrating wind and solar generation into the California's electricity grid. These challenges include: Smoothing intra-hour variability; - Absorbing excess renewable energy during over-generation periods; - Addressing morning and evening ramping periods. In addition, there are technical challenges to integrating retail demand response (DR) triggered by the wholesale conditions into the CAISO markets. The study describes the DR programs available to the consumers through the utilities in California and CAISO's ancillary services market because an integration of the wholesale and retail DR requires an understanding of these different offerings and the costs associated with acquiring them. Demand-side active and passive storage systems are proposed as technologies that may be used to mitigate the effects of intermittence due to renewable generation. Commercial building technologies as well as industrial facilities with storage capability are identified as targets for the field tests. Two systems used for ancillary services communications are identified as providing the triggers for DR enablement. Through the field tests, issues related to communication, automation and flexibility of demand-side resources will be explored and the performance of technologies that participate in the field tests will be evaluated. The major outcome of this research is identifying and defining flexibility of DR resources and optimized use of these resources to respond to grid conditions.

  8. Intermittent Fasting: Is the Wait Worth the Weight?

    Science.gov (United States)

    Stockman, Mary-Catherine; Thomas, Dylan; Burke, Jacquelyn; Apovian, Caroline M

    2018-04-26

    We review the underlying mechanisms and potential benefits of intermittent fasting (IF) from animal models and recent clinical trials. Numerous variations of IF exist, and study protocols vary greatly in their interpretations of this weight loss trend. Most human IF studies result in minimal weight loss and marginal improvements in metabolic biomarkers, though outcomes vary. Some animal models have found that IF reduces oxidative stress, improves cognition, and delays aging. Additionally, IF has anti-inflammatory effects, promotes autophagy, and benefits the gut microbiome. The benefit-to-harm ratio varies by model, IF protocol, age at initiation, and duration. We provide an integrated perspective on potential benefits of IF as well as key areas for future investigation. In clinical trials, caloric restriction and IF result in similar degrees of weight loss and improvement in insulin sensitivity. Although these data suggest that IF may be a promising weight loss method, IF trials have been of moderate sample size and limited duration. More rigorous research is needed.

  9. Maintenance immunosuppression with intermittent intravenous IL-2 receptor antibody therapy in renal transplant recipients.

    LENUS (Irish Health Repository)

    Gabardi, Steven

    2011-09-01

    To report what we believe to be the first 2 cases of long-term (>24 months) intermittent intravenous interleukin-2 receptor antibody (IL-2RA) therapy for maintenance immunosuppression following renal transplantation.

  10. Intermittency in the limit of a large number of correlated components

    International Nuclear Information System (INIS)

    Sisakyan, A.N.

    1991-01-01

    The phenomena of intermittency in multiple distributions is considered. It is shown that such irregularities arise naturally in the multicomponent description of correlation characteristics. 26 refs.; 2 figs.; 5 tabs

  11. Study of intermittent bifurcations and chaos in boost PFC converters by nonlinear discrete models

    International Nuclear Information System (INIS)

    Zhang Hao; Ma Xikui; Xue Bianling; Liu Weizeng

    2005-01-01

    This paper mainly deals with nonlinear phenomena like intermittent bifurcations and chaos in boost PFC converters under peak-current control mode. Two nonlinear models in the form of discrete maps are derived to describe precisely the nonlinear dynamics of boost PFC converters from two points of view, i.e., low- and high-frequency regimes. Based on the presented discrete models, both the evolution of intermittent behavior and the periodicity of intermittency are investigated in detail from the fast and slow-scale aspects, respectively. Numerical results show that the occurrence of intermittent bifurcations and chaos with half one line period is one of the most distinguished dynamical characteristics. Finally, we make some instructive conclusions, which prove to be helpful in improving the performances of practical circuits

  12. Domestic Water Consumption under Intermittent and Continuous Modes of Water Supply

    NARCIS (Netherlands)

    Fan, L.; Liu, G.; Wang, F.; Ritsema, C.J.; Geissen, V.

    2014-01-01

    Although an extensive literature emphasizes the disadvantages of intermittent water supply, it remains prevalent in rural areas of developing countries. Understanding the effects of water supply time restrictions on domestic water use activities and patterns, especially for hygienic purposes, is

  13. Coarse-graining intermittent intracellular transport: Two- and three-dimensional models

    Science.gov (United States)

    Lawley, Sean D.; Tuft, Marie; Brooks, Heather A.

    2015-10-01

    Viruses and other cellular cargo that lack locomotion must rely on diffusion and cellular transport systems to navigate through a biological cell. Indeed, advances in single particle tracking have revealed that viral motion alternates between (a) diffusion in the cytoplasm and (b) active transport along microtubules. This intermittency makes quantitative analysis of trajectories difficult. Therefore, the purpose of this paper is to construct mathematical methods to approximate intermittent dynamics by effective stochastic differential equations. The coarse-graining method that we develop is more accurate than existing techniques and applicable to a wide range of intermittent transport models. In particular, we apply our method to two- and three-dimensional cell geometries (disk, sphere, and cylinder) and demonstrate its accuracy. In addition to these specific applications, we also explain our method in full generality for use on future intermittent models.

  14. A One-Dimensional Atmospheric Boundary Layer Model: Intermittent Wind Shears and Thermal Stability at Night

    National Research Council Canada - National Science Library

    Turnick, Arnold

    2001-01-01

    A one-dimensional, time-dependent computer model of the atmospheric boundary layer was developed to simulate intermittent turbulence and the near-ground microclimate under nighttime stable conditions...

  15. Cardiovascular disease in obstructive sleep apnoea syndrome: the role of intermittent hypoxia and inflammation.

    LENUS (Irish Health Repository)

    Garvey, J F

    2012-02-01

    There is increasing evidence that intermittent hypoxia plays a role in the development of cardiovascular risk in obstructive sleep apnoea syndrome (OSAS) through the activation of inflammatory pathways. The development of translational models of intermittent hypoxia has allowed investigation of its role in the activation of inflammatory mechanisms and promotion of cardiovascular disease in OSAS. There are noticeable differences in the response to intermittent hypoxia between body tissues but the hypoxia-sensitive transcription factors hypoxia-inducible factor-1 and nuclear factor-kappaB appear to play a key role in mediating the inflammatory and cardiovascular consequences of OSAS. Expanding our understanding of these pathways, the cross-talk between them and the activation of inflammatory mechanisms by intermittent hypoxia in OSAS will provide new avenues of therapeutic opportunity for the disease.

  16. Introspection-based Periodicity Awareness Model for Intermittently Connected Mobile Networks

    NARCIS (Netherlands)

    Türkes, Okan; Scholten, Johan; Havinga, Paul J.M.

    Recently, context awareness in Intermittently Connected Mobile Networks (ICMNs) has gained popularity in order to discover social similarities among mobile entities. Nevertheless, most of the contextual methods depend on network knowledge obtained with unrealistic scenarios. Mobile entities should

  17. Economic intermittency in a two-country model of business cycles coupled by investment

    International Nuclear Information System (INIS)

    Saiki, Y.; Chian, A.C.L.; Yoshida, H.

    2011-01-01

    Highlights: → Intermittent economic behavior of Keynes-Goodwin type model is investigated. → After a transition the system keeps its memory before the transition. → The intermittent phenomena is examined from the business cycle patterns. → It is concluded that dynamical patterns do not alter much around the transition. - Abstract: Intermittent behavior of economic dynamics is investigated by a two-country model of Keynes-Goodwin type business cycles. Numerical simulations show that after an economic system evolves from weak chaos to strong chaos the system keeps its memory before the transition and its time series alternates episodically between periods of weakly and strongly chaotic fluctuations. In addition, we examine the intermittent phenomena from the view point of business cycle patterns near the crisis point.

  18. Multiplicity of Plasmodium falciparum infection following intermittent preventive treatment in infants

    NARCIS (Netherlands)

    Buchholz, Ulrike; Kobbe, Robin; Danquah, Ina; Zanger, Philipp; Reither, Klaus; Abruquah, Harry H.; Grobusch, Martin P.; Ziniel, Peter; May, Jürgen; Mockenhaupt, Frank P.

    2010-01-01

    Intermittent preventive treatment in infants with sulphadoxine-pyrimethamine (IPTi-SP) reduces malaria morbidity by 20% to 33%. Potentially, however, this intervention may compromise the acquisition of immunity, including the tolerance towards multiple infections with Plasmodium falciparum.

  19. Multiplicity of Plasmodium falciparum infection following intermittent preventive treatment in infants

    NARCIS (Netherlands)

    Buchholz, U.; Kobbe, R.; Danquah, I.; Zanger, P.; Reither, K.; Abruquah, H.H.; Grobusch, M.P.; Ziniel, P.; May, J.; Mockenhaupt, F.P.

    2010-01-01

    Background: Intermittent preventive treatment in infants with sulphadoxine-pyrimethamine (IPTi-SP) reduces malaria morbidity by 20% to 33%. Potentially, however, this intervention may compromise the acquisition of immunity, including the tolerance towards multiple infections with Plasmodium

  20. The Effects of Intermittent Flooding on Seedlings of Three Forest Species

    Science.gov (United States)

    P.H. Anderson; S.R. Pezeshki

    1999-01-01

    Under greenhouse conditions, seedlings of three forest species, baldcypress (Taxodium distichum), nuttall oak (Quercus nuttallii), and swamp chestnut oak (Quercus michauxii) were subjected to an intermittent flooding and subsequent physiological and growth responses to such conditions were evaluated....

  1. Trajectory Adjustments Underlying Task-Specific Intermittent Force Behaviors and Muscular Rhythms

    OpenAIRE

    Chen, Yi-Ching; Lin, Yen-Ting; Huang, Chien-Ting; Shih, Chia-Li; Yang, Zong-Ru; Hwang, Ing-Shiou

    2013-01-01

    Force intermittency is one of the major causes of motor variability. Focusing on the dynamics of force intermittency, this study was undertaken to investigate how force trajectory is fine-tuned for static and dynamic force-tracking of a comparable physical load. Twenty-two healthy adults performed two unilateral resistance protocols (static force-tracking at 75% maximal effort and dynamic force-tracking in the range of 50%-100% maximal effort) using the left hand. The electromyographic activi...

  2. Subsurface Controls on Stream Intermittency in a Semi-Arid Landscape

    Science.gov (United States)

    Dohman, J.; Godsey, S.; Thackray, G. D.; Hale, R. L.; Wright, K.; Martinez, D.

    2017-12-01

    Intermittent streams currently constitute 30% to greater than 50% of the global river network. In addition, the number of intermittent streams is expected to increase due to changes in land use and climate. These streams provide important ecosystem services, such as water for irrigation, increased biodiversity, and high rates of nutrient cycling. Many hydrological studies have focused on mapping current intermittent flow regimes or evaluating long-term flow records, but very few have investigated the underlying causes of stream intermittency. The disconnection and reconnection of surface flow reflects the capacity of the subsurface to accommodate flow, so characterizing subsurface flow is key to understanding stream drying. We assess how subsurface flow paths control local surface flows during low-flow periods, including intermittency. Water table dynamics were monitored in an intermittent reach of Gibson Jack Creek in southeastern Idaho. Four transects were delineated with a groundwater well located in the hillslope, riparian zone, and in the stream, for a total of 12 groundwater wells. The presence or absence of surface flow was determined by frequent visual observations as well as in situ loggers every 30m along the 200m study reach. The rate of surface water drying was measured in conjunction with temperature, precipitation, subsurface hydraulic conductivity, hillslope-riparian-stream connectivity and subsurface travel time. Initial results during an unusually wet year suggest different responses in reaches that were previously observed to occasionally cease flowing. Flows in the intermittent reaches had less coherent and lower amplitude diel variations during base flow periods than reaches that had never been observed to dry out. Our findings will help contribute to our understanding of mechanisms driving expansion and contraction cycles in intermittent streams, increase our ability to predict how land use and climate change will affect flow regimes, and

  3. Method for assessing the probability of accumulated doses from an intermittent source using the convolution technique

    International Nuclear Information System (INIS)

    Coleman, J.H.

    1980-10-01

    A technique is discussed for computing the probability distribution of the accumulated dose received by an arbitrary receptor resulting from several single releases from an intermittent source. The probability density of the accumulated dose is the convolution of the probability densities of doses from the intermittent releases. Emissions are not assumed to be constant over the brief release period. The fast fourier transform is used in the calculation of the convolution

  4. Visualization of intermittent blobby plasma transport in attached and detached plasmas of the NAGDIS-II

    International Nuclear Information System (INIS)

    Ohno, Noriyasu; Furuta, Katsuhiro; Takamura, Shuichi

    2004-01-01

    We investigated the intermittent convective plasma transport in a attached and/or detached plasma condition of the linear divertor plasma simulator, NAGDIS-II. Images taken by a fast-imaging camera clearly show that in attached plasmas, blobs are peeled off the bulk plasma, and propagate outward with an azimuthal motion. In detached plasmas, plasma turbulence observed near the plasma recombining region drives strong intermittent radial plasma transport, which could broaden the radial density profile. (author)

  5. Intermittent pneumatic compression of legs increases microcirculation in distant skeletal muscle.

    Science.gov (United States)

    Liu, K; Chen, L E; Seaber, A V; Johnson, G W; Urbaniak, J R

    1999-01-01

    Intermittent pneumatic compression has been established as a method of clinically preventing deep vein thrombosis, but the mechanism has not been documented. This study observed the effects of intermittent pneumatic compression of legs on the microcirculation of distant skeletal muscle. The cremaster muscles of 80 male rats were exposed, a specially designed intermittent pneumatic-compression device was applied to both legs for 60 minutes, and the microcirculation of the muscles was assessed by measurement of the vessel diameter in three categories (10-20, 21-40, and 41-70 microm) for 120 minutes. The results showed significant vasodilation in arterial and venous vessels during the application of intermittent pneumatic compression, which disappeared after termination of the compression. The vasodilation reached a maximum 30 minutes after initiation of the compression and could be completely blocked by an inhibitor of nitric oxide synthase, NG-monomethyl-L-arginine (10 micromol/min). A 120-minute infusion of NG-monomethyl-L-arginine, beginning coincident with 60 minutes of intermittent pneumatic compression, resulted in a significant decrease in arterial diameter that remained at almost the same level after termination of the compression. The magnitude of the decrease in diameter in the group treated with intermittent pneumatic compression and NG-monomethyl-L-arginine was comparable with that in the group treated with NG-monomethyl-L-arginine alone. The results imply that the production of nitric oxide is involved in the positive influence of intermittent pneumatic compression on circulation. It is postulated that the rapid increase in venous velocity induced by intermittent pneumatic compression produces strong shear stress on the vascular endothelium, which stimulates an increased release of nitric oxide and thereby causes systemic vasodilation.

  6. Intermittent energy restriction in type 2 diabetes: A short discussion of medication management

    OpenAIRE

    Carter, Sharayah; Clifton, Peter M; Keogh, Jennifer B

    2016-01-01

    AIM To discuss type 2 diabetes mellitus (T2DM) medication changes required during the popular 5:2 intermittent energy restriction (IER) diet. METHODS A search was conducted in MEDLINE, EMBASE, AMED, CINAHL and Cochrane library for original research articles investigating the use of very low calorie diets (VLCD) in people with T2DM. The search terms used included ?VLCD? or ?very low energy diet? or ?very low energy restriction? or ?IER? or ?intermittent fasting? or ?calorie restriction? or ?di...

  7. Quality of life and functional status after revascularization or conservative treatment in patients with intermittent claudication

    DEFF Research Database (Denmark)

    Hedeager Momsen, Anne-Mette; Bach Jensen, Martin; Norager, Charlotte Buchard

    2011-01-01

    Revascularization of patients with intermittent claudication (IC) is recommended only for selected patients who have chronic pain or disabling disease. However, improvement in the quality of life (QoL) could justify more widespread use.......Revascularization of patients with intermittent claudication (IC) is recommended only for selected patients who have chronic pain or disabling disease. However, improvement in the quality of life (QoL) could justify more widespread use....

  8. Solar Wind MHD Turbulence: Anomalous Scaling and Intermittency Effects in the Slow and Fast Wind

    Science.gov (United States)

    Salem, C.; Mangeney, A.; Bale, S. D.

    2007-12-01

    Although considerable progress has been made in the understanding of MHD turbulence over the past few decades through the analysis of in-situ solar wind data, two of the primary problems of solar wind MHD turbulence that still remain a puzzle are the nature of the nonlinear energy cascade, and the strong intermittent character of solar wind fluctuations in the inertial range. This intermittency modifies significantly the scaling exponents of actual power-law spectra, which are directly related to the physical nature of the energy cascade taking place in the solar wind. The identification of the most intermittent structures and their relation to dissipation represents then a crucial problem in the framework of turbulence. Anomalous scaling of both solar wind magnetic field and velocity fluctuations in the inertial range, as well as intermittency effects have recently been investigated in detail using Wavelet transforms on simultaneous WIND 3s resolution particle and magnetic field data from the 3DP and the MFi experiments respectively. Specifically, the Haar Wavelet transform is used to compute spectra, structure functions and probability distribution functions (PDFs). This powerful technique allows: (1) for a systematic study of intermittency effects on these spectra, structure functions and PDFs, thus for a clear determination of the actual scaling properties in the inertial range, and (2) for a direct and systematic identification of the most active, singular structures responsible for the intermittency in the solar wind. The analysis of structure functions and PDFs, as well as new results on the nature of the intermittent coherent structures will be presented. The turbulent properties and intermittency effects in different solar wind regimes will be also discussed.

  9. Acute interstitial nephritis induced by intermittent use of Rifampicin in patient with Brucellosis

    International Nuclear Information System (INIS)

    Salih, S. Bin; Kharal, M.; Qahtani, M.; Dahneem, L.; Nohair, S.

    2008-01-01

    Acute oliguric renal failure (ARF) developed in a patient 2 days after she was started on intermittent anti-Brucella therapy including rifampicin. The clinical picture was compatible with acute allergic interstitial nephritis. Renal histology revealed mainly acute tubular necrosis with mild tubulo-intertitial mononuclear cellular infiltrate. Intermittent therapy, as in our patient, has been the major factor in the development of rifampicin induced ARF in cases reviewed in literature. (author)

  10. Enhancing wastewater degradation and biogas production by intermittent operation of UASB reactors

    International Nuclear Information System (INIS)

    Nadais, Helena; Barbosa, Marta; Capela, Isabel; Arroja, Luis; Ramos, Christian G.; Grilo, Andre; Sousa, Silvia A.; Leitao, Jorge H.

    2011-01-01

    The present work establishes intermittent operation of UASB reactors as a novel form of enhancing the anaerobic degradation of complex wastewaters and its conversion to usable biogas. Results show that the average methane production rate is 25% higher with the intermittent operation than with the continuous mode, meaning that it could produce 25% more electricity or heat. The methanization efficiency obtained in intermittent UASB reactors is around 20% higher than in the continuous systems, confirming a higher biological degradation of the substrates. It has been suggested that intermittent operation causes a forced adaptation of the biomass towards the degradation of complex substrates and results from morphological analyses of the biomass developed in intermittent and continuous UASB reactors showed marked differences between them. In order to gain a deeper knowledge on how microbial populations are affected by these operational parameters, a strategy involving the amplification, cloning, and analysis of the nucleotide sequences of genes encoding the 16S ribosomal RNA was undertaken and is described in this work. This strategy allowed the identification of a total of 49 different sequences. Results from the molecular characterization of the microbial populations are consistent with the higher methanization efficiency of the intermittent mode of operation.

  11. Modeled intermittency risk for small streams in the Upper Colorado River Basin under climate change

    Science.gov (United States)

    Reynolds, Lindsay V.; Shafroth, Patrick B.; Poff, N. LeRoy

    2015-01-01

    Longer, drier summers projected for arid and semi-arid regions of western North America under climate change are likely to have enormous consequences for water resources and river-dependent ecosystems. Many climate change scenarios for this region involve decreases in mean annual streamflow, late summer precipitation and late-summer streamflow in the coming decades. Intermittent streams are already common in this region, and it is likely that minimum flows will decrease and some perennial streams will shift to intermittent flow under climate-driven changes in timing and magnitude of precipitation and runoff, combined with increases in temperature. To understand current intermittency among streams and analyze the potential for streams to shift from perennial to intermittent under a warmer climate, we analyzed historic flow records from streams in the Upper Colorado River Basin (UCRB). Approximately two-thirds of 115 gaged stream reaches included in our analysis are currently perennial and the rest have some degree of intermittency. Dry years with combinations of high temperatures and low precipitation were associated with more zero-flow days. Mean annual flow was positively related to minimum flows, suggesting that potential future declines in mean annual flows will correspond with declines in minimum flows. The most important landscape variables for predicting low flow metrics were precipitation, percent snow, potential evapotranspiration, soils, and drainage area. Perennial streams in the UCRB that have high minimum-flow variability and low mean flows are likely to be most susceptible to increasing streamflow intermittency in the future.

  12. On the degrees-of-freedom of the MIMO three-way channel with intermittent connectivity

    KAUST Repository

    Chaaban, Anas

    2017-08-29

    The degrees-of-freedom (DoF) of the multi-antenna three-way channel (3WC) with an intermittent node is studied. Special attention is given to the impact of adaptation when the intermittent node has the largest number of antennas. A non-adaptive transmission scheme based on interference alignment, zero-forcing, and erasure-channel treatment is proposed, and its corresponding DoF region is derived. Then, it is shown that this scheme achieves the sum-DoF of the intermittent channel, in addition to the DoF region of the nonintermittent one. Thus, adaptation is not necessary from those perspectives. To the contrary, it is shown that adaptation is necessary for achieving the DoF region of the intermittent case. This is shown by deriving an outer bound for the intermittent channel with nonadaptive encoding, and proposing an adaptive scheme which achieves DoF tuples outside this bound. This highlights the importance of cooperation in this intermittent network.

  13. [Impact of chronic intermittent hypoxia upon rat liver lipid metabolism and interventional effect of Tempol].

    Science.gov (United States)

    Zhao, Hai-yan; Chen, Bao-yuan; Guo, Run; Kong, Cheng-ying; Wan, Nan-sheng; Zhang, Jing

    2013-02-05

    To explore the impact of chronic intermittent hypoxia (CIH) upon rat liver lipid metabolism and effect of anti-oxidant Tempol. Male Wistar rats (n = 80) were randomly divided into intermittent hypoxia group (10, 20, 30, 40 times/h), intermittent hypoxia Tempol treatment group, intermittent hypoxia normal saline treatment group, intermittent air mimic group (IA) and blank control group (CG). Sections of liver were stained with hematoxylin and eosin. Serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured. Levels of liver homogenate triglyceride (TG), total cholesterol (TC), free fatty acids (FFA) and serum TG, TC, adiponectin (ADP) were measured. Liver histology: IH group exhibited hepatocellular swelling, hyperchromatosis, disrupted hepatocellular membrane. With the increase of frequency, there were local necrosis and infiltration of inflammatory cells. But no steatosis was seen. Tempol early treatment and IA groups exhibited no hepatocellular swelling or inflammatory cell infiltration. The activities of ALT and AST increased along with the increased frequency in IH group (all P Tempol treatment group, and more obviously when early intervention was applied (all P 0.05), and no difference in different frequencies in IH group (all P > 0.05). The levels of serum TG, TC in IH groups were higher than those in IA and CG groups while ADP was lower (all P Tempol treatment group, serum TG, TC decreased while ADP increased and changed more obviously when early intervention was applied (all P Tempol can block intermittent hypoxia associated with liver injury.

  14. Time limit and time at VO2max' during a continuous and an intermittent run.

    Science.gov (United States)

    Demarie, S; Koralsztein, J P; Billat, V

    2000-06-01

    The purpose of this study was to verify, by track field tests, whether sub-elite runners (n=15) could (i) reach their VO2max while running at v50%delta, i.e. midway between the speed associated with lactate threshold (vLAT) and that associated with maximal aerobic power (vVO2max), and (ii) if an intermittent exercise provokes a maximal and/or supra maximal oxygen consumption longer than a continuous one. Within three days, subjects underwent a multistage incremental test during which their vVO2max and vLAT were determined; they then performed two additional testing sessions, where continuous and intermittent running exercises at v50%delta were performed up to exhaustion. Subject's gas exchange and heart rate were continuously recorded by means of a telemetric apparatus. Blood samples were taken from fingertip and analysed for blood lactate concentration. In the continuous and the intermittent tests peak VO2 exceeded VO2max values, as determined during the incremental test. However in the intermittent exercise, peak VO2, time to exhaustion and time at VO2max reached significantly higher values, while blood lactate accumulation showed significantly lower values than in the continuous one. The v50%delta is sufficient to stimulate VO2max in both intermittent and continuous running. The intermittent exercise results better than the continuous one in increasing maximal aerobic power, allowing longer time at VO2max and obtaining higher peak VO2 with lower lactate accumulation.

  15. The Acute Effects of Intermittent Light Exposure in the Evening on Alertness and Subsequent Sleep Architecture

    Directory of Open Access Journals (Sweden)

    Minqi Yang

    2018-03-01

    Full Text Available Exposure to bright light is typically intermittent in our daily life. However, the acute effects of intermittent light on alertness and sleep have seldom been explored. To investigate this issue, we employed within-subject design and compared the effects of three light conditions: intermittent bright light (30-min pulse of blue-enriched bright light (~1000 lux, ~6000 K alternating with 30-min dim normal light (~5 lux, ~3600 K three times; continuous bright light; and continuous dim light on subjective and objective alertness and subsequent sleep structure. Each light exposure was conducted during the three hours before bedtime. Fifteen healthy volunteers (20 ± 3.4 years; seven males were scheduled to stay in the sleep laboratory for four separated nights (one for adaptation and the others for the light exposures with a period of at least one week between nights. The results showed that when compared with dim light, both intermittent light and continuous bright light significantly increased subjective alertness and decreased sleep efficiency (SE and total sleep time (TST. Intermittent light significantly increased objective alertness than dim light did during the second half of the light-exposure period. Our results suggested that intermittent light was as effective as continuous bright light in their acute effects in enhancing subjective and objective alertness and in negatively impacting subsequent sleep.

  16. Intermittent hypoxia in childhood: the harmful consequences versus potential benefits of therapeutic uses

    Directory of Open Access Journals (Sweden)

    Tatiana V. Serebrovskaya

    2015-05-01

    Full Text Available Intermittent hypoxia often occurs in early infancy in both preterm and term infants and especially at 36 to 44 weeks postmenstrual age. These episodes of intermittent hypoxia could result from sleep-disordered breathing or may be temporally unrelated to apnea or bradycardia events. There are numerous reports indicating adverse effects of intermittent hypoxia on development, behavior, academic achievement and cognition in children with sleep apnea syndrome. It remains uncertain the exact causative relationship between the neurocognitive and behavioral morbidities and intermittent hypoxia and/or its associated sleep fragmentation. On the other hand, well-controlled and moderate intermittent hypoxia conditioning/training has been used in sick children for treating their various forms of bronchial asthma, allergic dermatoses, autoimmune thyroiditis, cerebral palsy, and obesity. This review article provides an updated and impartial analysis on the currently available evidence in supporting either side of the seemingly contradictory scenarios. We wish to stimulate a comprehensive understanding of such a complex physiological phenomenon as intermittent hypoxia, which may be accompanied by other confounding factors (e.g. hypercapnia, polycythemia, in order to prevent or reduce its harmful consequences, while maximize its potential utility as an effective therapeutic tool in pediatric patients.

  17. Intermittency in non-homogeneous Wake and Jet Turbulence

    Science.gov (United States)

    Mahjoub, O. B.; Sekula, E.; Redondo, J. M.

    2010-05-01

    The scale to scale transfer and the structure functions are calculated and from these the intermittency parametres [1[3]. The estimates of turbulent diffusivity could also be measured. Some two point correlations and time lag calculations are used to investigate the local mixedness [4,5] and the temporal and spatial integral length scales obtained from both Lagrangian and Eulerian correlations and functions. We compare these results with both theoretical and experimental ones in the Laboratory with a wind tunnel at the wake of a grid or cillinder with and withoutand a near Wall. The a theoretical description of how to simulate intermittency following the model of Babiano et al. (1996) and the role of locality in higher order exponents is applied to the different flows. The information about turbulent jets is needed in several configurations providing basic information about the turbulent free jet, the circular jet and the turbulent wall jet. The experimental measurements of turbulent velocity is based on Acoustic Doppler Velocimeter measurements of the jet centerline and off centered radial positions in the tank at several distances from the wall. Spectral and structure function analysis are useful to determine the flow mixing ability using also flow visualization [6,7]. Results of experiments include the velocity distribution, entrainment angle of the jets, jet and wake average and fluctuating velocity, PDF's, Skewness and Kurthosis, velocity and vorticity standard deviation, boundary layers function and turbulence intensity . Different range of Wake and Jet flows show a maximum of turbulent intensity at a certain distance from the wall as it breaks the flow simmetry and adds large scale vorticity in the different experiments, these efects are also believed to occur in Geo-Astrophysical flows. [1] Babiano, A. (2002), On Particle dispersion processes in two-dimensional turbulence. In Turbulent mixing in geophysical flows. Eds. Linden P.F. and Redondo J.M., p. 2

  18. Intermittent hypoxia training protects cerebrovascular function in Alzheimer's disease

    Science.gov (United States)

    Manukhina, Eugenia B; Downey, H Fred; Shi, Xiangrong

    2016-01-01

    Alzheimer's disease (AD) is a leading cause of death and disability among older adults. Modifiable vascular risk factors for AD (VRF) include obesity, hypertension, type 2 diabetes mellitus, sleep apnea, and metabolic syndrome. Here, interactions between cerebrovascular function and development of AD are reviewed, as are interventions to improve cerebral blood flow and reduce VRF. Atherosclerosis and small vessel cerebral disease impair metabolic regulation of cerebral blood flow and, along with microvascular rarefaction and altered trans-capillary exchange, create conditions favoring AD development. Although currently there are no definitive therapies for treatment or prevention of AD, reduction of VRFs lowers the risk for cognitive decline. There is increasing evidence that brief repeated exposures to moderate hypoxia, i.e. intermittent hypoxic training (IHT), improve cerebral vascular function and reduce VRFs including systemic hypertension, cardiac arrhythmias, and mental stress. In experimental AD, IHT nearly prevented endothelial dysfunction of both cerebral and extra-cerebral blood vessels, rarefaction of the brain vascular network, and the loss of neurons in the brain cortex. Associated with these vasoprotective effects, IHT improved memory and lessened AD pathology. IHT increases endothelial production of nitric oxide (NO), thereby increasing regional cerebral blood flow and augmenting the vaso- and neuroprotective effects of endothelial NO. On the other hand, in AD excessive production of NO in microglia, astrocytes, and cortical neurons generates neurotoxic peroxynitrite. IHT enhances storage of excessive NO in the form of S-nitrosothiols and dinitrosyl iron complexes. Oxidative stress plays a pivotal role in the pathogenesis of AD, and IHT reduces oxidative stress in a number of experimental pathologies. Beneficial effects of IHT in experimental neuropathologies other than AD, including dyscirculatory encephalopathy, ischemic stroke injury, audiogenic

  19. Using Smart Devices to Measure Intermittent Noise in the Workplace

    Directory of Open Access Journals (Sweden)

    Benjamin Roberts

    2017-01-01

    Full Text Available Purpose: To determine the accuracy of smart devices (iPods to measure intermittent noise and integrate a noise dose in the workplace. Materials and Methods: In experiment 1, four iPods were each paired with a Larson Davis Spark dosimeter and exposed to randomly fluctuating pink noise in a reverberant sound chamber. Descriptive statistics and the mean difference between the iPod and its paired dosimeter were calculated for the 1-s data logged measurements. The calculated time weighted average (TWA was also compared between the devices. In experiment 2, 15 maintenance workers and 14 office workers wore an iPod and dosimeter during their work-shift for a maximum of five workdays. A mixed effects linear regression model was used to control for repeated measures and to determine the effect of the device type on the projected 8-h TWA. Results: In experiment 1, a total of 315,306 1-s data logged measurements were made. The interquartile range of the mean difference fell within ±2.0 A-weighted decibels (dBA, which is the standard used by the American National Standards Institute to classify a type 2 sound level meter. The mean difference of the calculated TWA was within ±0.5 dBA except for one outlier. In experiment 2, the results of the mixed effects model found that, on average, iPods measured an 8-h TWA 1.7 dBA higher than their paired dosimeters. Conclusion: This study shows that iPods have the ability to make reasonably accurate noise measurements in the workplace, but they are not as accurate as traditional noise dosimeters.

  20. Intermittent fasting attenuates lipopolysaccharide-induced neuroinflammation and memory impairment.

    Science.gov (United States)

    Vasconcelos, Andrea R; Yshii, Lidia M; Viel, Tania A; Buck, Hudson S; Mattson, Mark P; Scavone, Cristoforo; Kawamoto, Elisa M

    2014-05-06

    Systemic bacterial infections often result in enduring cognitive impairment and are a risk factor for dementia. There are currently no effective treatments for infection-induced cognitive impairment. Previous studies have shown that intermittent fasting (IF) can increase the resistance of neurons to injury and disease by stimulating adaptive cellular stress responses. However, the impact of IF on the cognitive sequelae of systemic and brain inflammation is unknown. Rats on IF for 30 days received 1 mg/kg of lipopolysaccharide (LPS) or saline intravenously. Half of the rats were subjected to behavioral tests and the other half were euthanized two hours after LPS administration and the hippocampus was dissected and frozen for analyses. Here, we report that IF ameliorates cognitive deficits in a rat model of sepsis by a mechanism involving NF-κB activation, suppression of the expression of pro-inflammatory cytokines, and enhancement of neurotrophic support. Treatment of rats with LPS resulted in deficits in cognitive performance in the Barnes maze and inhibitory avoidance tests, without changing locomotor activity, that were ameliorated in rats that had been maintained on the IF diet. IF also resulted in reduced levels of mRNAs encoding the LPS receptor TLR4 and inducible nitric oxide synthase (iNOS) in the hippocampus. Moreover, IF prevented LPS-induced elevation of IL-1α, IL-1β and TNF-α levels, and prevented the LPS-induced reduction of BDNF levels in the hippocampus. IF also significantly attenuated LPS-induced elevations of serum IL-1β, IFN-γ, RANTES, TNF-α and IL-6 levels. Taken together, our results suggest that IF induces adaptive responses in the brain and periphery that can suppress inflammation and preserve cognitive function in an animal model of systemic bacterial infection.

  1. Metabolic consequences of chronic intermittent mild stress exposure.

    Science.gov (United States)

    Thompson, Abigail K; Fourman, Sarah; Packard, Amy E B; Egan, Ann E; Ryan, Karen K; Ulrich-Lai, Yvonne M

    2015-10-15

    Chronic stress in humans has divergent effects on food intake, with some individuals reporting increased vs. decreased food intake during stress. This divergence may depend in part on stress intensity, with higher-intensity stressors preferentially promoting anorexia. Consistent with this idea, rodents given a high-intensity chronic variable stress paradigm have robustly decreased food intake and body weight gain. However, the metabolic effects of a less intense chronic stress paradigm are not clear. Thus in the present study, adult male rats were given chronic intermittent mild stress (CIMS) exposure (3 cycles, in which each cycle consists of once daily mild stress for 5 days/week for 2 weeks, followed by 2 weeks of no stress) vs. non-stress controls, combined with ongoing access to a palatable diet (PD; choice of chow, high-fat diet, 30% sucrose drink, and water) vs. control diet (chow and water). As expected, access to PD increased caloric intake, body weight gain, and adiposity, and impaired glucose tolerance. CIMS decreased body weight gain only during the first cycle of stress and did not affect body weight gain thereafter, regardless of diet. Moreover, CIMS did not alter total food intake, adiposity or glucose tolerance regardless of diet. Lastly, CIMS transiently increased high-fat diet preference in PD-fed rats during the first stress cycle. Collectively, these results suggest that CIMS has relatively modest metabolic effects that occur primarily during initial stress exposure. These results support the hypothesis that the metabolic consequences of chronic stress vary with stress intensity and/or frequency. Copyright © 2015 Elsevier Inc. All rights reserved.

  2. Apparatus producing constant cable tension for intermittent demand

    Science.gov (United States)

    Lauritzen, Ted

    1985-01-01

    The disclosed apparatus produces constant tension in superconducting electrical cable, or some other strand, under conditions of intermittent demand, as the cable is unreeled from a reel or reeled thereon. The apparatus comprises a pivotally supported swing frame on which the reel is rotatably supported, a rotary motor, a drive train connected between the motor and the reel and including an electrically controllable variable torque slip clutch, a servo transducer connected to the swing frame for producing servo input signals corresponding to the position thereof, a servo control system connected between the transducer and the clutch for regulating the torque transmitted by the clutch to maintain the swing frame in a predetermined position, at least one air cylinder connected to the swing frame for counteracting the tension in the cable, and pressure regulating means for supplying a constant air pressure to the cylinder to establish the constant tension in the cable, the servo system and the clutch being effective to produce torque on the reel in an amount sufficient to provide tension in the cable corresponding to the constant force exerted by the air cylinder. The drive train also preferably includes a fail-safe brake operable to its released position by electrical power in common with the servo system, for preventing rotation of the reel if there is a power failure. A shock absorber and biasing springs may also be connected to the swing frame, such springs biasing the frame toward its predetermined position. The tension in the cable may be measured by force measuring devices engageable with the bearings for the reel shaft, such bearings being supported for slight lateral movement. The reel shaft is driven by a Shmidt coupler which accommodates such movement.

  3. Apparatus producing constant cable tension for intermittent demand

    International Nuclear Information System (INIS)

    Lauritzen, T.

    1985-01-01

    The disclosed apparatus produces constant tension in superconducting electrical cable, or some other strand, under conditions of intermittent demand, as the cable is unreeled from a reel or reeled thereon. The apparatus comprises a pivotally supported swing frame on which the reel is rotatably supported, a rotary motor, a drive train connected between the motor and the reel and including an electrically controllable variable torque slip clutch, a servo transducer connected to the swing frame for producing servo input signals corresponding to the position thereof, a servo control system connected between the transducer and the clutch for regulating the torque transmitted by the clutch to maintain the swing frame in a predetermined position, at least one air cylinder connected to the swing frame for counteracting the tension in the cable, and pressure regulating means for supplying a constant air pressure to the cylinder to establish the constant tension in the cable, the servo system and the clutch being effective to produce torque on the reel in an amount sufficient to provide tension in the cable corresponding to the constant force exerted by the air cylinder. The drive train also preferably includes a fail-safe brake operable to its released position by electrical power in common with the servo system, for preventing rotation of the reel if there is a power failure. A shock absorber and biasing springs may also be connected to the swing frame, such springs biasing the frame toward its predetermined position. The tension in the cable may be measured by force measuring devices engageable with the bearings for the reel shaft, such bearings being supported for slight lateral movement. The reel shaft is driven by a Shmidt coupler which accommodates such movement

  4. Circadian Rhythms in Acute Intermittent Porphyria—a Pilot Study

    Science.gov (United States)

    Larion, Sebastian; Caballes, F. Ryan; Hwang, Sun-Il; Lee, Jin-Gyun; Rossman, Whitney Ellefson; Parsons, Judy; Steuerwald, Nury; Li, Ting; Maddukuri, Vinaya; Groseclose, Gale; Finkielstein, Carla V.; Bonkovsky, Herbert L.

    2013-01-01

    Acute intermittent porphyria (AIP) is an inherited disorder of heme synthesis wherein a partial deficiency of porphobilinogen [PBG] deaminase [PBGD], with other factors may give rise to biochemical and clinical manifestations of disease. The biochemical hallmarks of active AIP are relative hepatic heme deficiency and uncontrolled up-regulation of hepatic 5-aminolevulinic acid [ALA] synthase-1 [ALAS1] with overproduction of ALA and PBG. The treatment of choice is intravenous heme, which restores the deficient regulatory heme pool of the liver and represses ALAS1. Recently, heme has been shown to influence circadian rhythms by controlling their negative feedback loops. We evaluated whether subjects with AIP exhibited an altered circadian profile. Over a 21 h period, we measured levels of serum cortisol, melatonin, ALA, PBG, and mRNA levels [in peripheral blood mononuclear cells] of selected clock-controlled genes and genes involved in heme synthesis in 10 Caucasian [European-American] women who were either post-menopausal or had been receiving female hormone therapy, 6 of whom have AIP and 4 do not and are considered controls. Four AIP subjects with biochemical activity exhibited higher levels of PBG and lower levels and dampened oscillation of serum cortisol, and a trend for lower levels of serum melatonin, than controls or AIP subjects without biochemical activity. Levels of clock-controlled gene mRNAs showed significant increases over baseline in all subjects at 5 am and 11 pm, whereas mRNA levels of ALAS1, ALAS2, and PBGD were increased only at 11 pm in subjects with active AIP. This pilot study provides evidence for disturbances of circadian markers in women with active AIP that may trigger or sustain some common clinical features of AIP. PMID:23650938

  5. Acute intermittent hypoxia exposures enhance arterial oxygen delivery.

    Science.gov (United States)

    Zhang, Peizhen; Downey, H Fred; Shi, Xiangrong

    2010-09-01

    Physiological adaptations to intermittent hypoxia (IH) conditioning are based on the cumulative effect of repeated IH exposures. The present study sought to test the hypothesis that acute IH exposures would promote arterial O(2) delivery and regional tissue oxygenation. Changes in arterial O(2) saturation (SaO(2), oximeter), forearm muscle and cerebral tissue oxygenations (SmO(2) and ScO(2), near-infrared spectroscopy) were compared during five repeated hypoxia exposures (10 +/- 0.2% O(2) for 5-min each) interposed with four-minute inhalation of room air in 11 healthy subjects (24 +/- 0.9 y). Baseline, prehypoxia partial pressure of end-tidal O(2) (P(ET)O(2), mass spectrometer) and SaO(2) (107 +/- 2 mmHg and 97.3 +/- 0.3%) were decreased (P breathing frequency were similar. Arterial O(2) dissociation in terms of per unit decrease in P(ET)O(2) during hypoxia, i.e. the slope of SaO(2)/P(ET)O(2), was augmented (P = 0.0025) from 0.71 +/- 0.09%/mmHg during the first hypoxia bout to 1.39 +/- 0.15%/mmHg and 1.47 +/- 0.16%/mmHg during the second and the fifth bouts, respectively. Fractional muscle tissue O(2) extraction rate (SmO(2)D, i.e. normalized difference between SaO(2) and SmO(2)) progressively decreased (P e. normalized difference between SaO(2) and ScO(2)) did not decrease during hypoxia (P = 0.94). ScO(2)D during normoxia tended to increase (P = 0.089) following repeated IH exposures. We conclude that enhanced arterial O(2) delivery with repeated IH exposures serves as a compensatory mechanism to potentiate O(2) availability during hypoxia.

  6. Alcohol dependence induced in rats by semivoluntary intermittent intake

    Directory of Open Access Journals (Sweden)

    M.S. Macieira

    1997-09-01

    Full Text Available The objective of the present experiment was to assess ethyl alcohol (ETOH dependence brought about by a semivoluntary intermittent intake regimen in rats. Male Wistar rats weighing 150-250 g at the onset of the experiment were assigned to the following groups: 0% ETOH (N = 11, 5% ETOH (N = 20, 20% ETOH (N = 20 and 40% ETOH (N = 18. ETOH solutions were offered at the end of the day and overnight from Monday to Friday, and throughout weekends, for 90 days. The concentration of the ETOH solutions was increased in a stepwise fashion allowing the rats to get used to the taste of alcohol. Reposition of pure water was permitted during 1-h water drinking periods in the morning. Daily volume intake (± SEM averaged 25.4 ± 0.4 ml (0% ETOH, 23.8 ± 0.6 ml (5% ETOH, 17.6 ± 0.7 ml (20% ETOH and 17.5 ± 0.6 ml (40% ETOH. ETOH consumption differed significantly (P<0.05 among groups, averaging 4.4 ± 0.2 g kg-1 day-1 (5% ETOH, 10.3 ± 0.3 g kg-1 day-1 (20% ETOH and 26 ± 1.2 g kg-1 day-1 (40% ETOH. Furthermore, ETOH detection in plasma 10-12 h after offering the solution indicated that its consumption in the 40% ETOH group was sufficient to override its metabolism. Overt signs of ETOH dependence, such as increased thirst, hyperactivity, puffing, hair ruffling and startle responsiveness as well as reduced drowsiness, were significantly increased in the 20% and 40% ETOH groups compared to the 0% and 5% groups. Accordingly, the model described here proved to be a useful tool for the evaluation of subtle or moderate behavioral and physical consequences of long-term ETOH intake

  7. Normobaric, intermittent hypoxia conditioning is cardio- and vasoprotective in rats.

    Science.gov (United States)

    Manukhina, Eugenia B; Belkina, Ludmila M; Terekhina, Olga L; Abramochkin, Denis V; Smirnova, Elena A; Budanova, Olga P; Mallet, Robert T; Downey, H Fred

    2013-12-01

    Favorable versus detrimental cardiovascular responses to intermittent hypoxia conditioning (IHC) are heavily dependent on experimental or pathological conditions, including the duration, frequency and intensity of the hypoxia exposures. Recently, we demonstrated that a program of moderate, normobaric IHC (FIO2 9.5-10% for 5-10 min/cycle, with intervening 4 min normoxia, 5-8 cycles/day for 20 days) in dogs afforded robust cardioprotection against infarction and arrhythmias induced by coronary artery occlusion-reperfusion, but this protection has not been verified in other species. Accordingly, in this investigation cardio- as well as vasoprotection were examined in male Wistar rats completing the normobaric IHC program or a sham program in which the rats continuously breathed atmospheric air. Myocardial ischemia and reperfusion (IR) was imposed by occlusion and reperfusion of the left anterior descending coronary artery in in situ experiments and by subjecting isolated, perfused hearts to global ischemia-reperfusion. Cardiac arrhythmias and myocardial infarct size were quantified in in situ experiments. Endothelial function was evaluated from the relaxation to acetylcholine of norepinephrine-precontracted aortic rings taken from in situ IR experiments, and from the increase in coronary flow produced by acetylcholine in isolated hearts. IHC sharply reduced cardiac arrhythmias during ischemia and decreased infarct size by 43% following IR. Endothelial dysfunction in aorta was marked after IR in sham rats, but not significant in IHC rats. Similar findings were found for the coronary circulations of isolated hearts. These findings support the hypothesis that moderate, normobaric IHC is cardio- and vasoprotective in a rat model of IR.

  8. Surplus from and storage of electricity generated by intermittent sources

    Science.gov (United States)

    Wagner, Friedrich

    2016-12-01

    Data from the German electricity system for the years 2010, 2012, 2013, and 2015 are used and scaled up to a 100% supply by intermittent renewable energy sources (iRES). In the average, 330GW wind and PV power are required to meet this 100% target. A back-up system is necessary with the power of 89% of peak load. Surplus electricity accrues at high power levels. Curtailing surplus power to a large extent is found to be uneconomic. Demand-side management will suffer from the strong day-to-day variation of available surplus energy. A day storage is ineffective because of the day-night correlation of surplus power during winter. A seasonal storage loses its character when transformation losses are considered because it can contribute only after periods with excessive surplus production. The option of an oversized iRES system to feed the storage is also not effective because, in this case, energy can be taken directly from the large iRES supply, making storage superfluous. The capacities to be installed stress the difficulty to base heat supply and mobility also on iRES generated electricity in the future. As the German energy transition replaces one CO2-free electricity supply system by another one, no major reduction in CO2 emission can be expected till 2022, when the last nuclear reactor will be switched off. By 2022, an extremely oversized power supply system has to be created, which can be expected to continue running down spot-market electricity prices. The continuation of the economic response -to replace expensive gas fuel by cheap lignite- causes an overall increase in CO2 emission. The German GHG emission targets for 2020 and beyond are therefore in jeopardy.

  9. Intermittent hypoxia training protects cerebrovascular function in Alzheimer's disease.

    Science.gov (United States)

    Manukhina, Eugenia B; Downey, H Fred; Shi, Xiangrong; Mallet, Robert T

    2016-06-01

    Alzheimer's disease (AD) is a leading cause of death and disability among older adults. Modifiable vascular risk factors for AD (VRF) include obesity, hypertension, type 2 diabetes mellitus, sleep apnea, and metabolic syndrome. Here, interactions between cerebrovascular function and development of AD are reviewed, as are interventions to improve cerebral blood flow and reduce VRF. Atherosclerosis and small vessel cerebral disease impair metabolic regulation of cerebral blood flow and, along with microvascular rarefaction and altered trans-capillary exchange, create conditions favoring AD development. Although currently there are no definitive therapies for treatment or prevention of AD, reduction of VRFs lowers the risk for cognitive decline. There is increasing evidence that brief repeated exposures to moderate hypoxia, i.e. intermittent hypoxic training (IHT), improve cerebral vascular function and reduce VRFs including systemic hypertension, cardiac arrhythmias, and mental stress. In experimental AD, IHT nearly prevented endothelial dysfunction of both cerebral and extra-cerebral blood vessels, rarefaction of the brain vascular network, and the loss of neurons in the brain cortex. Associated with these vasoprotective effects, IHT improved memory and lessened AD pathology. IHT increases endothelial production of nitric oxide (NO), thereby increasing regional cerebral blood flow and augmenting the vaso- and neuroprotective effects of endothelial NO. On the other hand, in AD excessive production of NO in microglia, astrocytes, and cortical neurons generates neurotoxic peroxynitrite. IHT enhances storage of excessive NO in the form of S-nitrosothiols and dinitrosyl iron complexes. Oxidative stress plays a pivotal role in the pathogenesis of AD, and IHT reduces oxidative stress in a number of experimental pathologies. Beneficial effects of IHT in experimental neuropathologies other than AD, including dyscirculatory encephalopathy, ischemic stroke injury, audiogenic

  10. Hypobaric intermittent hypoxia attenuates hypoxia-induced depressor response.

    Directory of Open Access Journals (Sweden)

    Fang Cui

    Full Text Available Hypobaric intermittent hypoxia (HIH produces many favorable effects in the cardiovascular system such as anti-hypertensive effect. In this study, we showed that HIH significantly attenuated a depressor response induced by acute hypoxia.Sprague-Dawley rats received HIH in a hypobaric chamber simulating an altitude of 5000 m. The artery blood pressure (ABP, heart rate (HR and renal sympathetic nerve activity (RSNA were recorded in anesthetized control rats and rats received HIH. The baseline ABP, HR and RSNA were not different between HIH and control rats. Acute hypoxia-induced decrease in ABP was significantly attenuated in HIH rat compared with control rats. However, acute hypoxia-induced increases in HR and RSNA were greater in HIH rat than in control rats. After removal of bilateral ascending depressor nerves, acute hypoxia-induced depressor and sympathoexcitatory responses were comparable in control and HIH rats. Furthermore, acute hypoxia-induced depressor and sympathoexcitatory responses did not differ between control and HIH groups after blocking ATP-dependent K(+ channels by glibenclamide. The baroreflex function evaluated by intravenous injection of phenylephrine and sodium nitroprusside was markedly augmented in HIH rats compared with control rats. The pressor and sympathoexcitatory responses evoked by intravenous injection of cyanide potassium were also significantly greater in HIH rats than in control rats.Our findings suggest that HIH suppresses acute hypoxia-induced depressor response through enhancement of baroreflex and chemoreflex function, which involves activation of ATP-dependent K(+ channels. This study provides new information and underlying mechanism on the beneficiary effect of HIH on maintaining cardiovascular homeostasis.

  11. Quality of life of patients using intermittent urinary catheterization.

    Science.gov (United States)

    Fumincelli, Laís; Mazzo, Alessandra; Martins, José Carlos Amado; Henriques, Fernando Manuel Dias; Orlandin, Leonardo

    2017-07-10

    measure and compare the quality of life of neurogenic bladder patients using intermittent urinary catheterization who were going through rehabilitation in Brazil and Portugal. multicenter, quantitative, cross-sectional, observational-analytic and correlational study executed in Brazil and Portugal. Two data collection tools were used, being one questionnaire with sociodemographic and clinical data and the World Health Organization Quality of Life-bref. Patients were included who were over 18 years of age, suffering from neurogenic urinary bladder and using intermittent urinary catheterization. in the sample of Brazilian (n = 170) and Portuguese (n = 52) patients, respectively, most patients were single (87-51.2%; 25-48.1%), had finished primary education (47-45.3%; 31-59.6%) and were retired (70-41.2%; 21-40.4%). Spinal cord injury was the main cause of using the urinary catheter in both countries. The Brazilian patients presented higher mean quality of life scores in the psychological domain (68.9) and lower scores in the physical domain (58.9). The Portuguese patients presented higher scores in the psychological domain (68.4) and lower scores in the environment domain (59.4). The execution of intermittent urinary self-catheterization was significant for both countries. in the two countries, these patients' quality of life can be determined by the improvement in the urinary symptoms, independence, self-confidence, social relationships and access to work activities. mensurar e comparar a qualidade de vida de pacientes com bexiga neurogênica em uso do cateterismo urinário intermitente em processo de reabilitação, no Brasil e em Portugal. estudo multicêntrico, Brasil e Portugal, quantitativo, transversal, observacional-analítico e correlacional. Foram utilizados dois instrumentos de coleta, um questionário de dados sociodemográficos e clínicos e World Health Organization Quality Life-bref. Foram inclusos pacientes maiores de 18 anos, com bexiga urin

  12. Potential Benefits and Harms of Intermittent Energy Restriction and Intermittent Fasting Amongst Obese, Overweight and Normal Weight Subjects—A Narrative Review of Human and Animal Evidence

    Directory of Open Access Journals (Sweden)

    Michelle Harvie

    2017-01-01

    Full Text Available Intermittent energy restriction (IER has become popular as a means of weight control amongst people who are overweight and obese, and is also undertaken by normal weight people hoping spells of marked energy restriction will optimise their health. This review summarises randomised comparisons of intermittent and isoenergetic continuous energy restriction for weight loss to manage overweight and obesity. It also summarises the potential beneficial or adverse effects of IER on body composition, adipose stores and metabolic effects from human studies, including studies amongst normal weight subjects and relevant animal experimentation. Six small short term (<6 month studies amongst overweight or obese individuals indicate that intermittent energy restriction is equal to continuous restriction for weight loss, with one study reporting greater reductions in body fat, and two studies reporting greater reductions in HOMA insulin resistance in response to IER, with no obvious evidence of harm. Studies amongst normal weight subjects and different animal models highlight the potential beneficial and adverse effects of intermittent compared to continuous energy restriction on ectopic and visceral fat stores, adipocyte size, insulin resistance, and metabolic flexibility. The longer term benefits or harms of IER amongst people who are overweight or obese, and particularly amongst normal weight subjects, is not known and is a priority for further investigation.

  13. Role and Nature of Intermittency in Solar Wind Alfvénic Turbulence: Wind Observations.

    Science.gov (United States)

    Salem, C. S.; Mangeney, A.; Bale, S. D.

    2006-12-01

    In the Alfvénic regime, i.e. for frequencies below the local proton cyclotron frequency, solar wind MHD turbulence exhibits what appears like an inertial domain, with power-law spectra and scale-invariance, suggesting as in fluid turbulence, a nonlinear energy cascade from the large "energy containing" scales towards much smaller scales, where dissipation via kinetic effects is presumed to act. However, the intermittent character of the solar wind fluctuations in the inertial range is much more important than in ordinary fluids. Indeed, the fluctuations consist of a mixture of random fluctuations and small-scale "singular" or coherent structures. This intermittency modifies significantly the scaling exponents of actual power-law spectra, which are directly related to the physical nature of the energy cascade taking place in the solar wind. The identification of the most intermittent structures and their relation to dissipation represents then a crucial problem in the framework of turbulence. We will discuss here recent results on scaling laws and intermittency based on the use of Wavelet transforms on simultaneous WIND 3s resolution particle and magnetic field data from the 3DP and the MFi experiments respectively. More specifically, the Haar Wavelet transform is used to compute spectra, structure functions and probability distribution functions (PDFs). We show that this powerful technique allows: (1) for a systematic elimination of intermittency effects on spectra and structure functions and thus for a clear determination of the actual scaling properties in the inertial range, and (2) for a direct and systematic identification of the most active, singular structures responsible for the intermittency in the solar wind. The analysis of structure functions and PDFs will be reviewed and new results on the nature of the intermittent coherent structures will be presented.

  14. Anomalous scaling and the role of intermittency in solar wind MHD turbulence: new insights

    Science.gov (United States)

    Salem, C.; Mangeney, A.; Bale, S. D.; Veltri, P.; Bruno, R.

    2007-08-01

    In the Alfvénic regime, i.e. for frequencies below the local proton cyclotron frequency, solar wind MHD turbulence exhibits what appears like an inertial domain, with power-law spectra and scale-invariance, suggesting as in fluid turbulence, a nonlinear energy cascade from the large ``energy containing'' scales towards much smaller scales, where dissipation via kinetic effects is presumed to act. However, the intermittent character of the solar wind fluctuations in the inertial range is much more important than in ordinary fluids. Indeed, the fluctuations consist of a mixture of random fluctuations and small-scale ``singular'' or coherent structures. This intermittency modifies significantly the scaling exponents of actual power-law spectra, which are directly related to the physical nature of the energy cascade taking place in the solar wind. The identification of the most intermittent structures and their relation to dissipation represents then a crucial problem in the framework of turbulence. We will discuss here recent results on scaling laws and intermittency based on the use of Wavelet transforms on simultaneous WIND 3s resolution particle and magnetic field data from the 3DP and the MFi experiments respectively. More specifically, the Haar Wavelet transform is used to compute spectra, structure functions and probability distribution functions (PDFs). We show that this powerful technique allows: (1) for a systematic study of intermittency effects on these spectra, structure functions and PDFs, thus for a clear determination of the actual scaling properties in the inertial range, and (2) for a direct and systematic identification of the most active, singular structures responsible for the intermittency in the solar wind. The analysis of structure functions and PDFs and new results on the nature of the intermittent coherent structures will be presented.

  15. Blood lactate level in Wistar rats after four and twelve week intermittent aerobic training

    Directory of Open Access Journals (Sweden)

    Dewi N. Sari

    2013-08-01

    Full Text Available Background: Aerobic training can be done not only continuously, but also intermittently. Intermittent aerobic training aimed to get blood lactate level lower than continuous aerobic training. Blood lactate concentration in one of the various factors that determine training performance. However, until recently, little studies about intermittent aerobic training and blood lactate levels have been done. Therefore, this study aimed to measure blood lactate levels in Wistar rats after 4 and 12 weeks of intermittent aerobic training.Methods: 16 Wistar rats were divided into two groups, control and aerobic group. Every group was divided into two subgroups, 4-week and 12-week subgroup. Aerobic group performed training using T-6000 treadmill with a speed of 20 m/minute for 20 minutes, with resting period for 90 seconds every 5 minute. Measurements of lactate level was done with L-lactate (PAP Randox kit (LC2389.Results: Blood lactate level in the 4-week aerobic group was 2.11 mmol/L, while that of the 4-week control group was 1.82 mmol/L (p > 0.05. Meanwhile, lactate level in 12-week aerobic group was 1.71 mmol/L (p < 0.05, and significantly lower than in 12-week control group, which was 3.03 mmol/L.Conclusion: This study showed that lactate level after 12-week intermittent aerobic training was the lowest compared to 4-week intermittent aerobic and 12-week control group. (Med J Indones. 2013;22:141-5. doi: 10.13181/mji.v22i3.582Keywords: Blood lactate, intermittent aerobic training, Wistar rat

  16. Augmented surgical amounts for intermittent exotropia to prevent recurrence

    Directory of Open Access Journals (Sweden)

    Hatice Arda

    2014-01-01

    Full Text Available Purpose: The purpose was to evaluate the results of bilateral lateral rectus (BLR recession which is based on augmented surgical amounts of classical surgical table of Parks′ for basic and pseudo-divergence excess type intermittent exotropia [X(T]. Materials and Methods: Patients with X(T operated by the same surgeon and followed-up for at least 6 months were included. Patients with prior surgery, neurobehavioral and musculoskeletal conditions, strabismus different from that mentioned above X(T were excluded. All the patients received BLR only. The amount of the recession was increased by the amount needed to correct 5 prism diopters (PD more X(T than what was measured. After the operation, 1 st week, 2 nd and 6 months measurements were recorded. The patients were grouped according to their 1 st week (3-7 days postoperative examination as: >10 PD esotropia (Group 1, ≤10 PD esotropia (Group 2, exotropia (Group 3, and orthotropic (Group 4, respectively. Final surgical outcomes were classified as "good" (≤10 PD exotropia and ≤5 PD esotropia, "recurrence" (>10 PD exotropia and "overcorrected" (>5 esotropia. Results: Thirty-seven patients were included. The mean age was 6.78 ± 2.87 years (range: 2-12 years. Mean preoperative deviation was 29.72 ± 8.07 PD (range: 15-45 PD at distance and 20.94 ± 11.65 PD (range: 10-45 PD at near (P < 0.0001. There were 21 (56.8% patients in Group 1, 9 (24.3% patients in Group 2, 1 (2.7% patient in Group 3 and 6 (16.2% patients in Group 4. Initial esotropia was achieved in 30 (30/37 of the patients. Twenty-eight of them had good results at the end of the 6 months. Overall "motor surgical" success rate was found to be 89.2% (33/37 patients, with 1 (2.7% overcorrection and 3 (8.1% recurrences at the end of the 6 months. Conclusion: This study demonstrated that early overcorrection of 10-20 PD after X(T surgery can achieve acceptable motor outcomes in the first 6 months postoperative period.

  17. Impact of intermittent fasting on health and disease processes.

    Science.gov (United States)

    Mattson, Mark P; Longo, Valter D; Harvie, Michelle

    2017-10-01

    Humans in modern societies typically consume food at least three times daily, while laboratory animals are fed ad libitum. Overconsumption of food with such eating patterns often leads to metabolic morbidities (insulin resistance, excessive accumulation of visceral fat, etc.), particularly when associated with a sedentary lifestyle. Because animals, including humans, evolved in environments where food was relatively scarce, they developed numerous adaptations that enabled them to function at a high level, both physically and cognitively, when in a food-deprived/fasted state. Intermittent fasting (IF) encompasses eating patterns in which individuals go extended time periods (e.g., 16-48h) with little or no energy intake, with intervening periods of normal food intake, on a recurring basis. We use the term periodic fasting (PF) to refer to IF with periods of fasting or fasting mimicking diets lasting from 2 to as many as 21 or more days. In laboratory rats and mice IF and PF have profound beneficial effects on many different indices of health and, importantly, can counteract disease processes and improve functional outcome in experimental models of a wide range of age-related disorders including diabetes, cardiovascular disease, cancers and neurological disorders such as Alzheimer's disease Parkinson's disease and stroke. Studies of IF (e.g., 60% energy restriction on 2days per week or every other day), PF (e.g., a 5day diet providing 750-1100kcal) and time-restricted feeding (TRF; limiting the daily period of food intake to 8h or less) in normal and overweight human subjects have demonstrated efficacy for weight loss and improvements in multiple health indicators including insulin resistance and reductions in risk factors for cardiovascular disease. The cellular and molecular mechanisms by which IF improves health and counteracts disease processes involve activation of adaptive cellular stress response signaling pathways that enhance mitochondrial health, DNA repair

  18. Daily intermittent hypoxia enhances walking after chronic spinal cord injury

    Science.gov (United States)

    Hayes, Heather B.; Jayaraman, Arun; Herrmann, Megan; Mitchell, Gordon S.; Rymer, William Z.

    2014-01-01

    Objectives: To test the hypothesis that daily acute intermittent hypoxia (dAIH) and dAIH combined with overground walking improve walking speed and endurance in persons with chronic incomplete spinal cord injury (iSCI). Methods: Nineteen subjects completed the randomized, double-blind, placebo-controlled, crossover study. Participants received 15, 90-second hypoxic exposures (dAIH, fraction of inspired oxygen [Fio2] = 0.09) or daily normoxia (dSHAM, Fio2 = 0.21) at 60-second normoxic intervals on 5 consecutive days; dAIH was given alone or combined with 30 minutes of overground walking 1 hour later. Walking speed and endurance were quantified using 10-Meter and 6-Minute Walk Tests. The trial is registered at ClinicalTrials.gov (NCT01272349). Results: dAIH improved walking speed and endurance. Ten-Meter Walk time improved with dAIH vs dSHAM after 1 day (mean difference [MD] 3.8 seconds, 95% confidence interval [CI] 1.1–6.5 seconds, p = 0.006) and 2 weeks (MD 3.8 seconds, 95% CI 0.9–6.7 seconds, p = 0.010). Six-Minute Walk distance increased with combined dAIH + walking vs dSHAM + walking after 5 days (MD 94.4 m, 95% CI 17.5–171.3 m, p = 0.017) and 1-week follow-up (MD 97.0 m, 95% CI 20.1–173.9 m, p = 0.014). dAIH + walking increased walking distance more than dAIH after 1 day (MD 67.7 m, 95% CI 1.3–134.1 m, p = 0.046), 5 days (MD 107.0 m, 95% CI 40.6–173.4 m, p = 0.002), and 1-week follow-up (MD 136.0 m, 95% CI 65.3–206.6 m, p walking improved walking speed and distance in persons with chronic iSCI. The impact of dAIH is enhanced by combination with walking, demonstrating that combinatorial therapies may promote greater functional benefits in persons with iSCI. Classification of evidence: This study provides Class I evidence that transient hypoxia (through measured breathing treatments), along with overground walking training, improves walking speed and endurance after iSCI. PMID:24285617

  19. Sterilizing Activity of Fully Oral Intermittent Regimens against Mycobacterium Ulcerans Infection in Mice.

    Directory of Open Access Journals (Sweden)

    Aurélie Chauffour

    2016-10-01

    Full Text Available The treatment of Buruli ulcer (BU that is caused by Mycobacterium ulcerans, is currently based on a daily administration of rifampin and streptomycin (RIF-STR. A fully oral intermittent regimen would greatly simplify its treatment on the field.The objective of this study was to assess the bactericidal and sterilizing activities of intermittent oral regimens in a murine model of established M. ulcerans infection. Regimens combining rifapentine (RFP 20 mg/kg with either moxifloxacin (MXF 200 mg/kg, clarithromycin (CLR 100 mg/kg or bedaquiline (BDQ 25 mg/kg were administrated twice (2/7 or three (only for RFP-CLR 3/7 times weekly during 8 weeks. The bactericidal but also the sterilizing activities of these four intermittent oral regimens were at least as good as those obtained with control weekdays regimens, i.e. RFP-CLR 5/7 or RIF-STR 5/7. A single mouse from the RFP-MFX 2/7 group had culture-positive relapse at the end of the 28 weeks following treatment completion among the 157 mice treated with one of the four intermittent regimens (40 RFP-CLR 2/7, 39 RFP-CLR 3/7, 39 RFP-MXF 2/7, 39 RFP-BDQ 2/7.These results open the door for a fully intermittent oral drug regimen for BU treatment avoiding intramuscular injections and facilitating supervision by health care workers.

  20. Sterilizing Activity of Fully Oral Intermittent Regimens against Mycobacterium Ulcerans Infection in Mice.

    Science.gov (United States)

    Chauffour, Aurélie; Robert, Jérôme; Veziris, Nicolas; Aubry, Alexandra; Jarlier, Vincent

    2016-10-01

    The treatment of Buruli ulcer (BU) that is caused by Mycobacterium ulcerans, is currently based on a daily administration of rifampin and streptomycin (RIF-STR). A fully oral intermittent regimen would greatly simplify its treatment on the field. The objective of this study was to assess the bactericidal and sterilizing activities of intermittent oral regimens in a murine model of established M. ulcerans infection. Regimens combining rifapentine (RFP 20 mg/kg) with either moxifloxacin (MXF 200 mg/kg), clarithromycin (CLR 100 mg/kg) or bedaquiline (BDQ 25 mg/kg) were administrated twice (2/7) or three (only for RFP-CLR 3/7) times weekly during 8 weeks. The bactericidal but also the sterilizing activities of these four intermittent oral regimens were at least as good as those obtained with control weekdays regimens, i.e. RFP-CLR 5/7 or RIF-STR 5/7. A single mouse from the RFP-MFX 2/7 group had culture-positive relapse at the end of the 28 weeks following treatment completion among the 157 mice treated with one of the four intermittent regimens (40 RFP-CLR 2/7, 39 RFP-CLR 3/7, 39 RFP-MXF 2/7, 39 RFP-BDQ 2/7). These results open the door for a fully intermittent oral drug regimen for BU treatment avoiding intramuscular injections and facilitating supervision by health care workers.

  1. A meta-analysis of high dose, intermittent vitamin D supplementation among older adults.

    Directory of Open Access Journals (Sweden)

    Ya Ting Zheng

    Full Text Available BACKGROUND: The effects of intermittent, high dose vitamin D treatment in older adults have not been documented. We conducted a meta-analysis to provide a quantitative assessment of the efficiency of intermittent, high dose vitamin D treatment on falls, fractures, and mortality among older adults. METHODS: Electronic databases were searched for randomized controlled trials (RCTs on high dose, intermittent vitamin D supplementation among older adults. Two researchers independently screened the literature according to specified inclusive and exclusive criteria to extract the data. Meta-analysis was performed by using Review Manager 5.1.0 software. RESULTS: Nine trials were included in this meta-analysis. High dose, intermittent vitamin D therapy did not decrease all-cause mortality among older adults. The risk ratio (95% CI was 1.04 (0.91-1.17. No benefit was seen in fracture or fall prevention. The risk ratio for hip fractures (95% CI was 1.17 (0.97-1.41 while for non-vertebral fractures (95% CI it was 1.06 (0.91-1.22, and the risk ratio for falls (95% CI was 1.02 (0.96-1.08. Results remained robust after sensitivity analysis. CONCLUSION: Supplementation of intermittent, high dose vitamin D may not be effective in preventing overall mortality, fractures, or falls among older adults. The route of administration of vitamin D supplements may well change the physiological effects.

  2. Predicting alpine headwater stream intermittency: a case study in the northern Rocky Mountains

    Science.gov (United States)

    Sando, Thomas R.; Blasch, Kyle W.

    2015-01-01

    This investigation used climatic, geological, and environmental data coupled with observational stream intermittency data to predict alpine headwater stream intermittency. Prediction was made using a random forest classification model. Results showed that the most important variables in the prediction model were snowpack persistence, represented by average snow extent from March through July, mean annual mean monthly minimum temperature, and surface geology types. For stream catchments with intermittent headwater streams, snowpack, on average, persisted until early June, whereas for stream catchments with perennial headwater streams, snowpack, on average, persisted until early July. Additionally, on average, stream catchments with intermittent headwater streams were about 0.7 °C warmer than stream catchments with perennial headwater streams. Finally, headwater stream catchments primarily underlain by coarse, permeable sediment are significantly more likely to have intermittent headwater streams than those primarily underlain by impermeable bedrock. Comparison of the predicted streamflow classification with observed stream status indicated a four percent classification error for first-order streams and a 21 percent classification error for all stream orders in the study area.

  3. Chronic intermittent hypoxia preserves bone density in a mouse model of sleep apnea.

    Science.gov (United States)

    Torres, Marta; Montserrat, Josep M; Pavía, Javier; Dalmases, Mireia; Ros, Domenec; Fernandez, Yolanda; Barbé, Ferran; Navajas, Daniel; Farré, Ramon

    2013-12-01

    Very recent clinical research has investigated whether obstructive sleep apnea (OSA) may modulate bone homeostasis but the few data available are conflicting. Here we report novel data obtained in a mouse study specifically designed to determine whether chronic intermittent hypoxia realistically mimicking OSA modifies bone mineral density (BMD). Normal male and female mice and orchidectomized mice (N=10 each group) were subjected to a pattern of high-frequency intermittent hypoxia (20s at 5% and 40s at 21%, 60 cycles/h) for 6h/day. Identical groups breathing room air (normoxia) were the controls. After 32 days of intermittent hypoxia/normoxia the trabecular bone mineral density (BMD) in the peripheral femora were measured by micro-CT scanning. When compared with normoxia (two-way ANOVA), intermittent hypoxia did not significantly modify BMD in the three animal groups tested. Data in this study suggest that the type of intermittent hypoxia characterizing OSA, applied as a single challenge, preserves bone homeostasis. Copyright © 2013 Elsevier B.V. All rights reserved.

  4. Intermittent hypoxia alters gut microbiota diversity in a mouse model of sleep apnoea.

    Science.gov (United States)

    Moreno-Indias, Isabel; Torres, Marta; Montserrat, Josep M; Sanchez-Alcoholado, Lidia; Cardona, Fernando; Tinahones, Francisco J; Gozal, David; Poroyko, Valeryi A; Navajas, Daniel; Queipo-Ortuño, Maria I; Farré, Ramon

    2015-04-01

    We assessed whether intermittent hypoxia, which emulates one of the hallmarks of obstructive sleep apnoea (OSA), leads to altered faecal microbiome in a murine model. In vivo partial pressure of oxygen was measured in colonic faeces during intermittent hypoxia in four anesthetised mice. 10 mice were subjected to a pattern of chronic intermittent hypoxia (20 s at 5% O2 and 40 s at room air for 6 h·day(-1)) for 6 weeks and 10 mice served as normoxic controls. Faecal samples were obtained and microbiome composition was determined by 16S rRNA pyrosequencing and bioinformatic analysis by Quantitative Insights into Microbial Ecology. Intermittent hypoxia exposures translated into hypoxia/re-oxygenation patterns in the faeces proximal to the bowel epithelium (diversity (Shannon index, pgut microbiota (ANOSIM analysis of β-diversity, pdiversity are altered as a result of intermittent hypoxia realistically mimicking OSA, suggesting the possibility that physiological interplays between host and gut microbiota could be deregulated in OSA. Copyright ©ERS 2015.

  5. Effects of intermittent fasting on body composition and clinical health markers in humans.

    Science.gov (United States)

    Tinsley, Grant M; La Bounty, Paul M

    2015-10-01

    Intermittent fasting is a broad term that encompasses a variety of programs that manipulate the timing of eating occasions by utilizing short-term fasts in order to improve body composition and overall health. This review examines studies conducted on intermittent fasting programs to determine if they are effective at improving body composition and clinical health markers associated with disease. Intermittent fasting protocols can be grouped into alternate-day fasting, whole-day fasting, and time-restricted feeding. Alternate-day fasting trials of 3 to 12 weeks in duration appear to be effective at reducing body weight (≈3%-7%), body fat (≈3-5.5 kg), total cholesterol (≈10%-21%), and triglycerides (≈14%-42%) in normal-weight, overweight, and obese humans. Whole-day fasting trials lasting 12 to 24 weeks also reduce body weight (≈3%-9%) and body fat, and favorably improve blood lipids (≈5%-20% reduction in total cholesterol and ≈17%-50% reduction in triglycerides). Research on time-restricted feeding is limited, and clear conclusions cannot be made at present. Future studies should examine long-term effects of intermittent fasting and the potential synergistic effects of combining intermittent fasting with exercise. © The Author(s) 2015. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  6. Chronic intermittent fasting improves cognitive functions and brain structures in mice.

    Directory of Open Access Journals (Sweden)

    Liaoliao Li

    Full Text Available Obesity is a major health issue. Obesity started from teenagers has become a major health concern in recent years. Intermittent fasting increases the life span. However, it is not known whether obesity and intermittent fasting affect brain functions and structures before brain aging. Here, we subjected 7-week old CD-1 wild type male mice to intermittent (alternate-day fasting or high fat diet (45% caloric supplied by fat for 11 months. Mice on intermittent fasting had better learning and memory assessed by the Barnes maze and fear conditioning, thicker CA1 pyramidal cell layer, higher expression of drebrin, a dendritic protein, and lower oxidative stress than mice that had free access to regular diet (control mice. Mice fed with high fat diet was obese and with hyperlipidemia. They also had poorer exercise tolerance. However, these obese mice did not present significant learning and memory impairment or changes in brain structures or oxidative stress compared with control mice. These results suggest that intermittent fasting improves brain functions and structures and that high fat diet feeding started early in life does not cause significant changes in brain functions and structures in obese middle-aged animals.

  7. Chronic intermittent fasting improves cognitive functions and brain structures in mice.

    Science.gov (United States)

    Li, Liaoliao; Wang, Zhi; Zuo, Zhiyi

    2013-01-01

    Obesity is a major health issue. Obesity started from teenagers has become a major health concern in recent years. Intermittent fasting increases the life span. However, it is not known whether obesity and intermittent fasting affect brain functions and structures before brain aging. Here, we subjected 7-week old CD-1 wild type male mice to intermittent (alternate-day) fasting or high fat diet (45% caloric supplied by fat) for 11 months. Mice on intermittent fasting had better learning and memory assessed by the Barnes maze and fear conditioning, thicker CA1 pyramidal cell layer, higher expression of drebrin, a dendritic protein, and lower oxidative stress than mice that had free access to regular diet (control mice). Mice fed with high fat diet was obese and with hyperlipidemia. They also had poorer exercise tolerance. However, these obese mice did not present significant learning and memory impairment or changes in brain structures or oxidative stress compared with control mice. These results suggest that intermittent fasting improves brain functions and structures and that high fat diet feeding started early in life does not cause significant changes in brain functions and structures in obese middle-aged animals.

  8. Effects of intermittent fasting and chronic swimming exercise on body composition and lipid metabolism.

    Science.gov (United States)

    Moraes, Ruan Carlos Macedo de; Portari, Guilherme Vannucchi; Ferraz, Alex Soares Marreiros; da Silva, Tiago Eugênio Oliveira; Marocolo, Moacir

    2017-12-01

    Intermittent fasting protocol (IFP) has been suggested as a strategy to change body metabolism and improve health. The effects of IFP seem to be similar to aerobic exercise, having a hormetic adaptation according to intensity and frequency. However, the effects of combining both interventions are still unknown. Therefore, the aim of the present study was to evaluate the effects of IFP with and without endurance-exercise training on body composition, food behavior, and lipid metabolism. Twenty-week-old Wistar rats were kept under an inverted circadian cycle of 12 h with water ad libitum and assigned to 4 different groups: control group (ad libitum feeding and sedentary), exercise group (ad libitum feeding and endurance training), intermittent fasting group (IF; intermittent fasting and sedentary), and intermittent fasting and exercise group (IFEX; intermittent fasting and endurance training). After 6 weeks, the body weight of IF and IFEX animals decreased without changes in food consumption. Yet, the body composition between the 2 groups was different, with the IFEX animals containing higher total protein and lower total fat content than the IF animals. The IFEX group also showed increases in total high-density lipoprotein cholesterol and increased intramuscular lipid content. The amount of brown adipose tissue was higher in IF and IFEX groups; however, the IFEX group showed higher expression levels of uncoupling protein 1 in this tissue, indicating a greater thermogenesis. The IFP combined with endurance training is an efficient method for decreasing body mass and altering fat metabolism, without inflicting losses in protein content.

  9. Intermittent parathyroid hormone (PTH) promotes cementogenesis and alleviates the catabolic effects of mechanical strain in cementoblasts.

    Science.gov (United States)

    Li, Yuyu; Hu, Zhiai; Zhou, Chenchen; Xu, Yang; Huang, Li; Wang, Xin; Zou, Shujuan

    2017-04-20

    External root resorption, commonly starting from cementum, is a severe side effect of orthodontic treatment. In this pathological process and repairing course followed, cementoblasts play a significant role. Previous studies implicated that parathyroid hormone (PTH) could act on committed osteoblast precursors to promote differentiation, and inhibit apoptosis. But little was known about the role of PTH in cementoblasts. The purpose of this study was to investigate the effects of intermittent PTH on cementoblasts and its influence after mechanical strain treatment. Higher levels of cementogenesis- and differentiation-related biomarkers (bone sialoprotein (BSP), osteocalcin (OCN), Collagen type I (COL1) and Osterix (Osx)) were shown in 1-3 cycles of intermittent PTH treated groups than the control group. Additionally, intermittent PTH increased alkaline phosphatase (ALP) activity and mineralized nodules formation, as measured by ALP staining, quantitative ALP assay, Alizarin red S staining and quantitative calcium assay. The morphology of OCCM-30 cells changed after mechanical strain exertion. Expression of BSP, ALP, OCN, osteopontin (OPN) and Osx was restrained after 18 h mechanical strain. Furthermore, intermittent PTH significantly increased the expression of cementogenesis- and differentiation-related biomarkers in mechanical strain treated OCCM-30 cells. Taken together, these data suggested that intermittent PTH promoted cementum formation through activating cementogenesis- and differentiation-related biomarkers, and attenuated the catabolic effects of mechanical strain in immortalized cementoblasts OCCM-30.

  10. Indwelling versus Intermittent Urinary Catheterization following Total Joint Arthroplasty: A Systematic Review and Meta-Analysis.

    Directory of Open Access Journals (Sweden)

    Wei Zhang

    Full Text Available The purpose of this study is to compare the rates of urinary tract infection (UTI and postoperative urinary retention (POUR in patients undergoing lower limb arthroplasty after either indwelling urinary catheterization or intermittent urinary catheterization.We conducted a meta-analysis of relevant randomized controlled trials (RCT to compare the rates of UTI and POUR in patients undergoing total joint arthroplasty after either indwelling urinary catheterization or intermittent urinary catheterization. A comprehensive search was carried out to identify RCTs. Study-specific risk ratios (RR with 95% confidence intervals (CI were pooled. Additionally, a meta-regression analysis, as well as a sensitivity analysis, was performed to evaluate the heterogeneity.Nine RCTs with 1771 patients were included in this meta-analysis. The results showed that there was no significant difference in the rate of UTIs between indwelling catheterization and intermittent catheterization groups (P>0.05. Moreover, indwelling catheterization reduced the risk of POUR, versus intermittent catheterization, in total joint surgery (P<0.01.Based on the results of the meta-analysis, indwelling urinary catheterization, removed 24-48 h postoperatively, was superior to intermittent catheterization in preventing POUR. Furthermore, indwelling urinary catheterization with removal 24 to 48 hours postoperatively did not increase the risk of UTI. In patients with multiple risk factors for POUR undergoing total joint arthroplasty of lower limb, the preferred option should be indwelling urinary catheterization removed 24-48 h postoperatively.Level I.

  11. Apolipoprotein E-deficient mice exhibit increased vulnerability to intermittent hypoxia-induced spatial learning deficits.

    Science.gov (United States)

    Kheirandish, Leila; Row, Barry W; Li, Richard C; Brittian, Kenneth R; Gozal, David

    2005-11-01

    Exposure to intermittent hypoxia, such as occurs in sleep-disordered breathing, is associated with oxidative stress, cognitive impairments, and increased neuronal apoptosis in brain regions involved in learning and memory. Apolipoprotein E (ApoE) has been implicated in neurodegenerative disorders, and in vitro studies suggest that one of the functions of ApoE may be to confer protection from oxidant stress-induced neuronal cell loss. Therefore, we hypothesized that ApoE-deficient (ApoE-/-) mice would display increased cognitive impairments following intermittent hypoxia. Twenty-four young adult male mice (ApoE-/-) and 24 wild-type littermates (ApoE +/+) were exposed to 14 days of normoxia (room air; n=12 per group) or intermittent hypoxia (5.7% O2 alternating with 21% O2 every 90 seconds, 12 daylight hours per day; n=12 per group). Behavioral testing consisting of a standard place-training reference memory task in the water maze revealed that ApoE+/+ and ApoE-/- mice exposed to intermittent hypoxia were found to require significantly longer times (latency) and distances (pathlength) to locate the hidden platform (P hypoxia-exposed ApoE-/- mice were impaired on the final two days of training (P E2 and malondiadehyde concentrations were present in hippocampal brain tissues following intermittent hypoxia but were significantly higher in ApoE-/- mice (P breathing and may underlie the increased prevalence of Apolipoprotein E4 in patients with sleep-disordered breathing.

  12. Metabolic syndrome in patients with prostate cancer undergoing intermittent androgen-deprivation therapy.

    Science.gov (United States)

    Rezaei, Mohammadali Mohammadzadeh; Rezaei, Mohammadhadi Mohammadzadeh; Ghoreifi, Alireza; Kerigh, Behzad Feyzzadeh

    2016-01-01

    The presence of metabolic syndrome in men with prostate cancer (PCa) undergoing androgen-deprivation therapy (ADT), especially intermittent type, has not been completely evaluated. The aim of this study is to evaluate metabolic syndrome in men with PCa undergoing intermittent ADT. In this longitudinal study, we studied the prevalence of metabolic syndrome and its components in 190 patients who were undergoing intermittent ADT. The metabolic syndrome was defined according to the Adult Treatment Panel III criteria. All metabolic parameters, including lipid profile, blood glucose, blood pressures, and waist circumferences of the patients were measured six and 12 months after treatment. Mean age of the patients was 67.5 ± 6.74 years. The incidence of metabolic syndrome after six and 12 months was 6.8% and 14.7%, respectively. Analysis of various components of the metabolic syndrome revealed that patients had significantly higher overall prevalence of hyperglycemia, abdominal obesity, and hypertriglyceridemia in their six- and 12-month followups, but blood pressure has not been changed in the same period except for diastolic blood pressure after six months. Although there was an increased risk of metabolic syndrome in patients receiving intermittent ADT, it was lower than other studies that treated the same patients with continuous ADT. Also it seems that intermittent ADT has less metabolic complications than continuous ADT and could be used as a safe alternative in patients with advanced and metastatic PCa.

  13. An intermittency route to global instability in low-density jets

    Science.gov (United States)

    Murugesan, Meenatchidevi; Zhu, Yuanhang; Li, Larry K. B.

    2017-11-01

    Above a critical Reynolds number (Re), a low-density jet can become globally unstable, transitioning from a steady state (i.e. a fixed point) to a self-excited oscillatory state (i.e. a limit cycle) via a Hopf bifurcation. In this experimental study, we show that this transition can sometimes involve intermittency. When Re is just slightly above the critical point, intermittent bursts of high-amplitude periodic oscillations emerge amidst a background of low-amplitude aperiodic fluctuations. As Re increases further, these intermittent bursts persist longer in time until they dominate the overall dynamics, causing the jet to transition fully to a periodic limit cycle. We identify this as Type-II Pomeau-Manneville intermittency by quantifying the statistical distribution of the duration of the aperiodic fluctuations at the onset of intermittency. This study shows that the transition to global instability in low-density jets is not always abrupt but can involve an intermediate state with characteristics of both the initial fixed point and the final limit cycle. This work was supported by the Research Grants Council of Hong Kong (Project No. 16235716 and 26202815).

  14. Exposure to intermittent nociceptive stimulation under pentobarbital anesthesia disrupts spinal cord function in rats

    Science.gov (United States)

    Patton, Brianne C.; Ferguson, Adam R.; Hudson, Kara L.; Grau, James W.

    2011-01-01

    Rationale Spinal cord plasticity can be assessed in spinal rats using an instrumental learning paradigm in which subjects learn an instrumental response, hindlimb flexion, to minimize shock exposure. Prior exposure to uncontrollable intermittent stimulation blocks learning in spinal rats but has no effect if given before spinal transection, suggesting that supraspinal systems modulate nociceptive input to the spinal cord, rendering it less susceptible to the detrimental consequences of uncontrollable stimulation. Objective The present study examines whether disrupting brain function with pentobarbital blocks descending inhibitory systems that normally modulate nociceptive input, making the spinal cord more sensitive to the adverse effect of uncontrollable intermittent stimulation. Materials and methods Male Sprague–Dawley rats received uncontrollable intermittent stimulation during pentobarbital anesthesia after (experiment 1) or before (experiment 2) spinal cord transection. They were then tested for instrumental learning at a later time point. Experiment 3 examined whether these manipulations affected nociceptive (thermal) thresholds. Results Experiment 1 showed that pentobarbital had no effect on the induction of the learning deficit after spinal cord transection. Experiment 2 showed that intact rats anesthetized during uncontrollable intermittent stimulation failed to learn when later transected and tested for instrumental learning. Experiment 3 found that uncontrollable intermittent stimulation induced an antinociception in intact subjects that was blocked by pentobarbital. Conclusions The results suggest a surgical dose of pentobarbital (50 mg/kg) suppresses supraspinal (experiment 2) but not spinal (experiment 1) systems that modulate nociceptive input to the spinal cord by blocking the antinociception that is induced by this input (experiment 3). PMID:17297638

  15. [The Effect of Chronic Intermittent Hypoxia on Cognitive Function and Prefrontal Cortex Neurons in Rats].

    Science.gov (United States)

    Li, Li-qun; Cao, Jin-li; Li, Lin; Han, Xiao-qing; Wang, Hong-yang; Liang, Xiao-mei; Wang, Ling; Zhang, Min; Wang, Ya-nan; Duan, Li-jun

    2015-09-01

    To determine the effect of chronic intermittent hypoxia on cognitive function and prefrontal cortex neurons in rats. 48 adult male Wistar rats were randomly divided into two groups: control group and 50 mL/L intermittent hypoxia group (50 mL/L CIH). Rats in the CIH group were placed in the low oxygen tank, simulating intermittent hypoxia environment. At 7 d, 14 d, 21 d, and 28 d, the learning and memory ability of the rats was assessed with the Morris water maze (MWM) test; the expressions of cysteinyl aspartate specific protease (caspase)-8 protein in their prefrontal cortex were determined using Western blot method; the apoptosis of neurons was detected by the TdT mediated UTP nick end labeling (TUNEL) method. Compared with the controls, the CIH rats had significantly prolonged escape latency at 14 d, 21 d, and 28 d (Phypoxia (Phypoxia (Phypoxia can lead to pathological changes of frontal,cortex of rats, possibly

  16. Characterizing the Effects of Intermittent Faults on a Processor for Dependability Enhancement Strategy

    Directory of Open Access Journals (Sweden)

    Chao(Saul Wang

    2014-01-01

    Full Text Available As semiconductor technology scales into the nanometer regime, intermittent faults have become an increasing threat. This paper focuses on the effects of intermittent faults on NET versus REG on one hand and the implications for dependability strategy on the other. First, the vulnerability characteristics of representative units in OpenSPARC T2 are revealed, and in particular, the highly sensitive modules are identified. Second, an arch-level dependability enhancement strategy is proposed, showing that events such as core/strand running status and core-memory interface events can be candidates of detectable symptoms. A simple watchdog can be deployed to detect application running status (IEXE event. Then SDC (silent data corruption rate is evaluated demonstrating its potential. Third and last, the effects of traditional protection schemes in the target CMT to intermittent faults are quantitatively studied on behalf of the contribution of each trap type, demonstrating the necessity of taking this factor into account for the strategy.

  17. Implementation of Environmental Flows for Intermittent River Systems: Adaptive Management and Stakeholder Participation Facilitate Implementation

    Science.gov (United States)

    Conallin, John; Wilson, Emma; Campbell, Josh

    2018-03-01

    Anthropogenic pressure on freshwater ecosystems is increasing, and often leading to unacceptable social-ecological outcomes. This is even more prevalent in intermittent river systems where many are already heavily modified, or human encroachment is increasing. Although adaptive management approaches have the potential to aid in providing the framework to consider the complexities of intermittent river systems and improve utility within the management of these systems, success has been variable. This paper looks at the application of an adaptive management pilot project within an environmental flows program in an intermittent stream (Tuppal Creek) in the Murray Darling Basin, Australia. The program focused on stakeholder involvement, participatory decision-making, and simple monitoring as the basis of an adaptive management approach. The approach found that by building trust and ownership through concentrating on inclusiveness and transparency, partnerships between government agencies and landholders were developed. This facilitated a willingness to accept greater risks and unintended consequences allowing implementation to occur.

  18. A randomized trial of automated intermittent ropivacaine administration vs. continuous infusion in an interscalene catheter

    DEFF Research Database (Denmark)

    Oxlund, J; Clausen, A H; Venø, S

    2018-01-01

    BACKGROUND: Ultrasound-guided interscalene nerve block with ropivacaine as local anesthetic agent given as boluses or continuous infusion is the preferred pain management after major shoulder surgery. The use of automated intermittent boluses has been shown to be superior to continuous infusion....... Patients were allocated to either automated intermittent boluses with 16 mg ropivacaine every 2 h combined with patient-controlled administration or to a conventional regimen of continuous infusion of 8 mg/h (4 ml/h) of ropivacaine combined with patient controlled administration (2 ml, lockout time 30 min......). Pain (Visual Analog Scale, VAS) was assessed every 8 h postoperatively. RESULTS: Fifty-seven patients completed the study, 29 in the continuous infusion group and 28 in the automated intermittent bolus group. Shoulder arthroplasty was performed in 49 (86%) of the cases. There were no significant...

  19. Height fluctuations and intermittency of V sub 2 O sub 5 films by atomic force microscopy

    CERN Document Server

    Iraji-Zad, A; Tabar, M R R; Allaei, S M V

    2003-01-01

    The spatial scaling law and intermittency of the V sub 2 O sub 5 surface roughness has been investigated by atomic force microscopy. The intermittency of the height fluctuations has been checked by two different methods, first, by measuring the scaling exponent of the q-th moment of height-difference fluctuations i.e. C sub q = (|h(x sub 1) - h(x sub 2)|), and second, by defining the generating function Z(q, N) and generalized multi-fractal dimension D sub q. These methods predict that there is no intermittency in the height fluctuations. The observed roughness and dynamical exponents can be explained by numerical simulation on the basis of the forced Kuramoto-Sivashinsky equation.

  20. Outdoor validation of the 30 minutes intermittent tracking of 100 x CPV

    Science.gov (United States)

    Araki, Kenji; Ota, Yasuyuki; Lee, Kan-Hua; Nishioka, Kensuke; Yamaguchi, Masafumi

    2017-09-01

    HCPV uses trackers, but their cost and reliability have raised problems. These problems may be solved by substantially increasing acceptance angle and mechanical tolerance. For a demonstration of the possibility of such substantial improvement, a 30 minutes intermittent tracking in high concentration applications was examined. To allow for 30 minutes intermittent tracking, both advanced optics and an advanced tracking control were investigated. For advanced optics, a 100 x refractive and dielectric concentrator was designed. It had about plus or minus 5° of acceptance angle. For advanced tracking control, a feed-forward control with a linear error correction was investigated. With combining both optimizations, it was shown that 30 minutes intermittent tracking was validated in outdoor experiments even for an as high as 100 x concentration.

  1. Linear response in aging glassy systems, intermittency and the Poisson statistics of record fluctuations

    DEFF Research Database (Denmark)

    Sibani, Paolo

    2007-01-01

    in a correlated fashion and through irreversible bursts, `quakes', which punctuate reversible and equilibrium-like fluctuations of zero average. The temporal distribution of the quakes is a Poisson distribution with an average growing logarithmically on time, indicating that the quakes are triggered by record...... to capture the time dependencies of the EA simulation results. Finally, we argue that whenever the changes of the linear response function and of its conjugate autocorrelation function follow from the same intermittent events a fluctuation-dissipation-like relation can arise between the two in off......We study the intermittent behavior of the energy decay and the linear magnetic response of a glassy system during isothermal aging after a deep thermal quench, using the Edward-Anderson spin glass model as a paradigmatic example. The large intermittent changes in the two observables occur...

  2. Characterizing the effects of intermittent faults on a processor for dependability enhancement strategy.

    Science.gov (United States)

    Wang, Chao Saul; Fu, Zhong-Chuan; Chen, Hong-Song; Wang, Dong-Sheng

    2014-01-01

    As semiconductor technology scales into the nanometer regime, intermittent faults have become an increasing threat. This paper focuses on the effects of intermittent faults on NET versus REG on one hand and the implications for dependability strategy on the other. First, the vulnerability characteristics of representative units in OpenSPARC T2 are revealed, and in particular, the highly sensitive modules are identified. Second, an arch-level dependability enhancement strategy is proposed, showing that events such as core/strand running status and core-memory interface events can be candidates of detectable symptoms. A simple watchdog can be deployed to detect application running status (IEXE event). Then SDC (silent data corruption) rate is evaluated demonstrating its potential. Third and last, the effects of traditional protection schemes in the target CMT to intermittent faults are quantitatively studied on behalf of the contribution of each trap type, demonstrating the necessity of taking this factor into account for the strategy.

  3. Knockdown of angiopoietin-like 2 mimics the benefits of intermittent fasting on insulin responsiveness and weight loss.

    Science.gov (United States)

    Martel, Cécile; Pinçon, Anthony; Bélanger, Alexandre Maxime; Luo, Xiaoyan; Gillis, Marc-Antoine; de Montgolfier, Olivia; Thorin-Trescases, Nathalie; Thorin, Éric

    2018-01-01

    Angiopoietin-like 2 (ANGPTL2) is an inflammatory adipokine linking obesity to insulin resistance. Intermittent fasting, on the other hand, is a lifestyle intervention able to prevent obesity and diabetes but difficult to implement and maintain. Our objectives were to characterize a link between ANGPTL2 and intermittent fasting and to investigate whether the knockdown of ANGPTL2 reproduces the benefits of intermittent fasting on weight gain and insulin responsiveness in knockdown and wild-type littermates mice. Intermittent fasting, access to food ad libitum once every other day, was initiated at the age of three months and maintained for four months. Intermittent fasting decreased by 63% (p fasting improved insulin sensitivity (p fasting regimen: insulin sensitivity and weight gain were identical, while intermittent fasting had no additional impact on these parameters in knockdown mice. Energy intake was similar between both wild-type fed intermittent fasting and ANGPTL2 knockdown mice fed ad libitum, suggesting that intermittent fasting and knockdown of ANGPTL2 equally lower feeding efficiency. These results suggest that the reduction of ANGPTL2 could be a useful and promising strategy to prevent obesity and insulin resistance, although further investigation of the mechanisms linking ANGPTL2 and intermittent fasting is warranted. Impact statement Intermittent fasting is an efficient diet pattern to prevent weight gain and improve insulin sensitivity. It is, however, a difficult regimen to follow and compliance is expected to be very low. In this work, we demonstrate that knockdown of ANGPTL2 in mice fed ad libitum mimics the beneficial effects of intermittent fasting on weight gain and insulin sensitivity in wild-type mice. ANGPTL2 is a cytokine positively associated with fat mass in humans, which inactivation in mice improves resistance to a high-fat metabolic challenge. This study provides a novel pathway by which IF acts to limit obesity despite equivalent

  4. Serum Endostatin Concentrations Are Higher in Men with Symptoms of Intermittent Claudication

    Directory of Open Access Journals (Sweden)

    Jonathan Golledge

    2014-01-01

    Full Text Available Objectives. A cleavage fragment of collagen XVIII, endostatin, is released into the circulation and has been demonstrated to have antiangiogenic effects in animal models. We hypothesized that circulating endostatin would be increased in patients with symptoms of lower limb peripheral artery disease. Design. Cross-sectional study. Participants. Community dwelling older men. Measurements. Intermittent claudication was defined using the Edinburgh Claudication Questionnaire (ECQ. Serum endostatin was measured by a commercial ELISA. The association of serum endostatin with intermittent claudication was examined using logistic regression adjusting for age, diabetes, hypertension, dyslipidemia, coronary heart disease, and stroke. Results. Serum endostatin was measured in 1114 men who completed the ECQ. 106 men had intermittent claudication, 291 had atypical pain, and 717 had no lower limb pain. Mean (±standard deviation serum endostatin concentrations (ng/mL were 145.22 ± 106.93 for men with intermittent claudication, 129.11 ± 79.80 for men with atypical pain, and 116.34 ± 66.57 for men with no lower limb pain; P<0.001. A 70 ng/mL increase in endostatin was associated with a 1.17-fold rise in the adjusted odds of having intermittent claudication (OR 1.17, 95% confidence interval 1.00–1.37, and P=0.050. Conclusions. Serum endostatin is raised in older men who have symptoms of intermittent claudication. The role of endostatin in the genesis and outcome of peripheral artery disease requires further investigation.

  5. Male fertility is reduced by chronic intermittent hypoxia mimicking sleep apnea in mice.

    Science.gov (United States)

    Torres, Marta; Laguna-Barraza, Ricardo; Dalmases, Mireia; Calle, Alexandra; Pericuesta, Eva; Montserrat, Josep M; Navajas, Daniel; Gutierrez-Adan, Alfonso; Farré, Ramon

    2014-11-01

    Obstructive sleep apnea (OSA) is characterized by intermittent hypoxia and oxidative stress. However, it is unknown whether intermittent hypoxia mimicking OSA modifies male fertility. We tested the hypothesis that male fertility is reduced by chronic intermittent hypoxia mimicking OSA in a mouse model. Case-control comparison in a murine model. University research laboratory. Eighteen F1 (C57BL/6xCBA) male mice. Mice were subjected to a pattern of periodic hypoxia (20 sec at 5% O2 followed by 40 sec of room air) 6 h/day for 60 days or normoxia. After this period, mice performed a mating trial to determine effective fertility by assessing the number of pregnant females and fetuses. After euthanasia, oxidative stress in testes was assessed by measuring the expression of glutathione peroxidase 1 (Gpx1) and superoxide dismutase-1 (Sod1) by reverse-transcription polymerase chain reaction. Sperm motility was determined by Integrated Semen Analysis System (ISAS). Intermittent hypoxia significantly increased testicular oxidative stress, showing a reduction in the expression of Gpx1 and Sod1 by 38.9% and 34.4%, respectively, as compared with normoxia (P hypoxia group (P = 0.04). The proportion of pregnant females and number of fetuses per mating was significantly lower in the intermittent hypoxia group (0.33 ± 0.10 and 2.45 ± 0.73, respectively) than in normoxic controls (0.72 ± 0.16 and 5.80 ± 1.24, respectively). These results suggest that the intermittent hypoxia associated with obstructive sleep apnea (OSA) could induce fertility reduction in male patients with this sleep breathing disorder.

  6. Effects of flow intermittency and pharmaceutical exposure on the structure and metabolism of stream biofilms.

    Science.gov (United States)

    Corcoll, Natàlia; Casellas, Maria; Huerta, Belinda; Guasch, Helena; Acuña, Vicenç; Rodríguez-Mozaz, Sara; Serra-Compte, Albert; Barceló, Damià; Sabater, Sergi

    2015-01-15

    Increasing concentrations of pharmaceutical compounds occur in many rivers, but their environmental risk remains poorly studied in stream biofilms. Flow intermittency shapes the structure and functions of ecosystems, and may enhance their sensitivity to toxicants. This study evaluates the effects of a long-term exposure of biofilm communities to a mixture of pharmaceutical compounds at environmental concentrations on biofilm bioaccumulation capacity, the structure and metabolic processes of algae and bacteria communities, and how their potential effects were enhanced or not by the occurrence of flow intermittency. To assess the interaction between those two stressors, an experiment with artificial streams was performed. Stream biofilms were exposed to a mixture of pharmaceuticals, as well as to a short period of flow intermittency. Results indicate that biofilms were negatively affected by pharmaceuticals. The algal biomass and taxa richness decreased and unicellular green algae relatively increased. The structure of the bacterial (based on denaturing gradient gel electrophoresis of amplified 16S rRNA genes) changed and showed a reduction of the operational taxonomic units (OTUs) richness. Exposed biofilms showed higher rates of metabolic processes, such as primary production and community respiration, attributed to pharmaceuticals stimulated an increase of green algae and heterotrophs, respectively. Flow intermittency modulated the effects of chemicals on natural communities. The algal community became more sensitive to short-term exposure of pharmaceuticals (lower EC50 value) when exposed to water intermittency, indicating cumulative effects between the two assessed stressors. In contrast to algae, the bacterial community became less sensitive to short-term exposure of pharmaceuticals (higher EC50) when exposed to water intermittency, indicating co-tolerance phenomena. According to the observed effects, the environmental risk of pharmaceuticals in nature is high

  7. Effect of work:rest cycle duration on [Formula: see text] fluctuations during intermittent exercise.

    Science.gov (United States)

    Combes, Adrien; Dekerle, Jeanne; Bougault, Valérie; Daussin, Frédéric N

    2017-01-01

    The succession of on-transient phases that induce a repetition of metabolic changes is a possible mechanism responsible for the greater response to intermittent training (IT). The objective of this study was to quantify [Formula: see text] fluctuations during intermittent exercise characterised by the same work:rest ratio, but different durations and identify which duration leads to the greatest fluctuations. Ten participants (24 ± 5 years; [Formula: see text]: 42 ± 7 mL·min -1 ·kg -1 ) performed (1) an incremental test to exhaustion to determine peak work rate (WR peak ) and oxygen uptake ([Formula: see text]), (2), and three 1 h intermittent exercises alternating work period at 70% WR peak with passive recovery period of different 1:1 work:recovery duty cycles (30 s:30 s, 60 s:60 s, 120 s:120 s). [Formula: see text] response analysis revealed differences in the fluctuations across the intermittent conditions despite an identical total energy expenditure. The sum of the cycle's nadir-to-peak [Formula: see text] differences (ΣΔ[Formula: see text]) and the oxygen fluctuation index (OFI) were both greater in the 60 s:60 s condition (ΣΔ[Formula: see text]: +38% ± 13% and +19% ± 18% vs. 120 s:120 s and 30 s:30 s, P see text] fluctuation analysis was successful in identifying the intermittent condition associated with the greatest disturbances: the 60 s:60 s duty cycle induces more [Formula: see text] fluctuations. The present findings also demonstrate that the selection of the duty cycle duration for submaximal intermittent exercise (70% of WR peak ) prescription is of interest to produce high [Formula: see text] fluctuations.

  8. Intermittent fasting modulation of the diabetic syndrome in sand rats. II. In vivo investigations.

    Science.gov (United States)

    Belkacemi, Louiza; Selselet-Attou, Ghalem; Louchami, Karim; Sener, Abdullah; Malaisse, Willy J

    2010-11-01

    This study deals with the effects of daily intermittent fasting for 15 h upon the development of diabetes in sand rats exposed to a hypercaloric diet. The same pattern of daily intermittent fasting was imposed on sand rats maintained on a purely vegetal diet (control animals). Over the last 30 days of the present experiments, non-fasting animals gained weight, whilst intermittently fasting sand rats lost weight. In this respect, there was no significant difference between control animals and either diabetic or non-diabetic sand rats exposed to the hypercaloric diet. The postprandial glycemia remained fairly stable in the control animals. During a 3-week transition period from a purely vegetal to a hypercaloric diet, the post-prandial glycemia increased by 5.95 ± 1.26 mM (n=6) in diabetic sand rats, as distinct from an increase of only 0.45 ± 0.56 mM (n=6) in the non-diabetic animals. During the intermittent fasting period, the postprandial glycemia decreased significantly in the diabetic animals, but not so in the non-diabetic sand rats. Before the switch in food intake, the peak glycemia at the 30th min of an intraperitoneal glucose tolerance test was already higher in the diabetic than non-diabetic rats. In both the non-diabetic and diabetic sand rats, intermittent fasting prevented the progressive deterioration of glucose tolerance otherwise observed in non-fasting animals. These findings reveal that, at least in sand rats, intermittent daily fasting prevents the progressive deterioration of glucose tolerance otherwise taking place when these animals are exposed to a hypercaloric diet.

  9. Water quality effects of intermittent water supply in Arraiján, Panama.

    Science.gov (United States)

    Erickson, John J; Smith, Charlotte D; Goodridge, Amador; Nelson, Kara L

    2017-05-01

    Intermittent drinking water supply is common in low- and middle-income countries throughout the world and can cause water quality to degrade in the distribution system. In this study, we characterized water quality in one study zone with continuous supply and three zones with intermittent supply in the drinking water distribution network in Arraiján, Panama. Low or zero pressures occurred in all zones, and negative pressures occurred in the continuous zone and two of the intermittent zones. Despite hydraulic conditions that created risks for backflow and contaminant intrusion, only four of 423 (0.9%) grab samples collected at random times were positive for total coliform bacteria and only one was positive for E. coli. Only nine of 496 (1.8%) samples had turbidity >1.0 NTU and all samples had ≥0.2 mg/L free chlorine residual. In contrast, water quality was often degraded during the first-flush period (when supply first returned after an outage). Still, routine and first-flush water quality under intermittent supply was much better in Arraiján than that reported in a previous study conducted in India. Better water quality in Arraiján could be due to better water quality leaving the treatment plant, shorter supply outages, higher supply pressures, a more consistent and higher chlorine residual, and fewer contaminant sources near pipes. The results illustrate that intermittent supply and its effects on water quality can vary greatly between and within distribution networks. The study also demonstrated that monitoring techniques designed specifically for intermittent supply, such as continuous pressure monitoring and sampling the first flush, can detect water quality threats and degradation that would not likely be detected with conventional monitoring. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Mouse Intermittent Hypoxia Mimicking Apnea of Prematurity: Effects on Myelinogenesis and Axonal Maturation

    Science.gov (United States)

    CAI, JUN; TUONG, CHI MINH; ZHANG, YIPING; SHIELDS, CHRISTOPHER B.; GUO, GANG; FU, HUI; GOZAL, DAVID

    2014-01-01

    Premature babies are at high risk for both infantile apnea and long-term neurobehavioral deficits. Recent studies suggest that diffuse structural changes in brain white matter are a positive predictor of poor cognitive outcomes. Since oligodendrocyte maturation, myelination, axon development and synapse formation mainly occur in the 3rd trimester of gestation and 1st postnatal year, infantile apnea could lead to and/or exaggerate white matter impairments in preterm neonates. Therefore, we investigated oligodendroglia and axon development in a neonatal mouse model of intermittent hypoxia between postnatal days 2 to 10. During critical phases of central nervous system development, intermittent hypoxia induced hypomyelination in the corpus callosum, striatum, fornix and cerebellum, but not the pons or spinal cord. Intermittent hypoxia-elicited alterations in myelin-forming processes were reflected by decreased expression of myelin proteins, including MBP, PLP, MAG and CNPase, possibly due to arrested maturation of oligodendrocytes. Ultra-structural abnormalities were apparent in the myelin sheath and axon. Immature oligodendrocytes were more vulnerable to neonatal intermittent hypoxia exposures than developing axons, suggesting that hypomyelination may contribute, at least partially, to axonal deficits. Insufficient neurofilament synthesis with anomalous components of neurofilament subunits, β-tubulin and MAP2 isoforms indicated immaturity of axons in intermittent hypoxia-exposed mouse brains. In addition, down-regulation of Synapsin I, Synaptophysin and Gap-43 phosphorylation suggested a potential stunt in axonogenesis and synaptogenesis. The region-selective and complex impairment in brain white matter induced by intermittent hypoxia was further associated with electrophysiological changes that may underlie long-term neurobehavioral sequelae. PMID:21953180

  11. Scale-Invariance and Intermittency in the Solar Wind Alfvénic Turbulence: Wind Observations

    Science.gov (United States)

    Salem, C. S.; Mangeney, A.; Bale, S. D.; Veltri, P.

    2004-12-01

    In the "Alfvénic" regime, i.e. for frequencies below the local proton cyclotron frequency, solar wind MHD turbulence exhibits what appears like an inertial domain, with power-law spectra and scale-invariance, suggesting as in fluid turbulence, a nonlinear energy cascade from the large "energy containing" scales towards the small scales where dissipation by kinetic effects is presumed to act. However, the intermittent character of solar wind fluctuations is much more important than in ordinary fluids. Indeed, the fluctuations consist of a mixture of random fluctuations and small-scale "singular" or coherent structures. This intermittency modifies significantly the scaling exponents of actual power-law spectra, which are directly related to the physical nature of the energy cascade taking place in the solar wind. The identification of the most intermittent structures and their relation to dissipation represents then a crucial problem in the framework of turbulence. We present here a new approach to study the scaling laws and intermittency based on the use of Wavelet transforms on simultaneous WIND 3s resolution particle and magnetic field data from the 3DP and the MFi experiments respectively. Using the Haar wavelet transform, spectra and structure functions are calculated. We show that this powerful technique allows: (1) for a systematic elimination of intermittency effects on spectra and structure functions and thus for a clear determination of the actual scaling properties in the inertial range, and (2) for a direct and systematic identification of the most active, singular structures responsible for the intermittency in the solar wind. We finally discuss the various effects which may be important for the formation of these structures in the absence of collisions.

  12. Muscle protein metabolism in neonatal alloxan-administered rats: effects of continuous and intermittent swimming training

    Directory of Open Access Journals (Sweden)

    Ribeiro Carla

    2012-02-01

    Full Text Available Abstract Background This study aimed to examine the effects of intermittent and continuous swimming training on muscle protein metabolism in neonatal alloxan-administered rats. Methods Wistar rats were used and divided into six groups: sedentary alloxan (SA, sedentary control (SC, continuous trained alloxan (CA, intermittent trained alloxan (IA, continuous trained control (CC and intermittent trained control (IC. Alloxan (250 mg/kg body weight was injected into newborn rats at 6 days of age. The continuous training protocol consisted of 12 weeks of swimming training in individual cylinder tanks while supporting a load that was 5% of body weight; uninterrupted swimming for 1 h/day, five days a week. The intermittent training protocol consisted of 12 weeks of swimming training in individual cylinder tanks while supporting a load that was 15% of body weight; 30 s of activity interrupted by 30 s of rest for a total of 20 min/day, five days a week. Results At 28 days, the alloxan animals displayed higher glycemia after glucose overload than the control animals. No differences in insulinemia among the groups were detected. At 120 days, no differences in serum albumin and total protein among the groups were observed. Compared to the other groups, DNA concentrations were higher in the alloxan animals that were subjected to continuous training, whereas the DNA/protein ratio was higher in the alloxan animals that were subjected to intermittent training. Conclusion It was concluded that continuous and intermittent training sessions were effective in altering muscle growth by hyperplasia and hypertrophy, respectively, in alloxan-administered animals.

  13. A protocol of intermittent exercise (shuttle runs) to train young basketball players.

    Science.gov (United States)

    Zadro, Ivan; Sepulcri, Luigino; Lazzer, Stefano; Fregolent, Rudy; Zamparo, Paola

    2011-06-01

    The purpose of this study was to set up a protocol of intermittent exercise to train young basketball players. Twenty-one players were asked to complete (a) an incremental test to determine maximal oxygen uptake (VO2max), the speed at the ventilatory threshold (vthr) and the energy cost of "linear" running (Cr) and (b) an intermittent test composed of 10 shuttle runs of 10-second duration and 30-seconds of recovery (total duration: about 6 minutes). The exercise intensity (the running speed, vi) was set at 130% of vthr. During the intermittent tests, oxygen uptake (VO2) and blood lactate concentration (Lab) were measured. The average pretraining VO2 calculated for a single bout (131 ± 9 ml · min(-1) kg(-1)) was about 2.4 times greater than the subjects' measured VO2max (54.7 ± 4.6 ml · min(-1) · kg(-1)). The net energy cost of running (9.2 ± 0.9 J · m(-1) · kg(-1)) was about 2.4 times higher than that measured at constant "linear" speed (3.9 ± 0.3 J · m(-1) · kg(-1)). The intermittent test was repeated after 7 weeks of training: 9 subjects (control group [CG]) maintained their traditional training schedule, whereas for 12 subjects (experimental group [EG]) part of the training was replaced by intermittent exercise (the same shuttle test as described above). After training, the VO2 measured during the intermittent test was significantly reduced (p basketball players.

  14. Removing Barriers for Effective Deployment of Intermittent Renewable Generation

    Science.gov (United States)

    Arabali, Amirsaman

    The stochastic nature of intermittent renewable resources is the main barrier to effective integration of renewable generation. This problem can be studied from feeder-scale and grid-scale perspectives. Two new stochastic methods are proposed to meet the feeder-scale controllable load with a hybrid renewable generation (including wind and PV) and energy storage system. For the first method, an optimization problem is developed whose objective function is the cost of the hybrid system including the cost of renewable generation and storage subject to constraints on energy storage and shifted load. A smart-grid strategy is developed to shift the load and match the renewable energy generation and controllable load. Minimizing the cost function guarantees minimum PV and wind generation installation, as well as storage capacity selection for supplying the controllable load. A confidence coefficient is allocated to each stochastic constraint which shows to what degree the constraint is satisfied. In the second method, a stochastic framework is developed for optimal sizing and reliability analysis of a hybrid power system including renewable resources (PV and wind) and energy storage system. The hybrid power system is optimally sized to satisfy the controllable load with a specified reliability level. A load-shifting strategy is added to provide more flexibility for the system and decrease the installation cost. Load shifting strategies and their potential impacts on the hybrid system reliability/cost analysis are evaluated trough different scenarios. Using a compromise-solution method, the best compromise between the reliability and cost will be realized for the hybrid system. For the second problem, a grid-scale stochastic framework is developed to examine the storage application and its optimal placement for the social cost and transmission congestion relief of wind integration. Storage systems are optimally placed and adequately sized to minimize the sum of operation

  15. A non-inferiority, individually randomized trial of intermittent screening and treatment versus intermittent preventive treatment in the control of malaria in pregnancy

    DEFF Research Database (Denmark)

    Tagbor, Harry; Cairns, Matthew; Bojang, Kalifa

    2015-01-01

    BACKGROUND: The efficacy of intermittent preventive treatment for malaria with sulfadoxine-pyrimethamine (IPTp-SP) in pregnancy is threatened in parts of Africa by the emergence and spread of resistance to SP. Intermittent screening with a rapid diagnostic test (RDT) and treatment of positive wom...... receiving cotrimoxazole prophylaxis in whom SP is contraindicated. TRIAL REGISTRATION: ClinicalTrials.gov NCT01084213 Pan African Clinical trials Registry PACT201202000272122....... (ISTp) is an alternative approach. METHODS AND FINDINGS: An open, individually randomized, non-inferiority trial of IPTp-SP versus ISTp was conducted in 5,354 primi- or secundigravidae in four West African countries with a low prevalence of resistance to SP (The Gambia, Mali, Burkina Faso and Ghana...

  16. Potential Benefits and Harms of Intermittent Energy Restriction and Intermittent Fasting Amongst Obese, Overweight and Normal Weight Subjects-A Narrative Review of Human and Animal Evidence.

    Science.gov (United States)

    Harvie, Michelle; Howell, Anthony

    2017-01-19

    Intermittent energy restriction (IER) has become popular as a means of weight control amongst people who are overweight and obese, and is also undertaken by normal weight people hoping spells of marked energy restriction will optimise their health. This review summarises randomised comparisons of intermittent and isoenergetic continuous energy restriction for weight loss to manage overweight and obesity. It also summarises the potential beneficial or adverse effects of IER on body composition, adipose stores and metabolic effects from human studies, including studies amongst normal weight subjects and relevant animal experimentation. Six small short term (benefits or harms of IER amongst people who are overweight or obese, and particularly amongst normal weight subjects, is not known and is a priority for further investigation.

  17. Intermittency patterns in pp collisions at 360 GeV/c

    International Nuclear Information System (INIS)

    Singh, J.B.; Kohli, J.M.

    1991-01-01

    The intermittency effect has been observed in pp collisions at 360 GeV/c and the strength decreases with the increase in multiplicity. The low multiplicity events in pp data (n ch ≤ 8), anti pp collisions (n ch ≤ 15) at Collider energy and elementary interaction (e + e - , μp) samples have almost the same strength. Most likely, few sources seem to contribute at lower multiplications. The intermittency effect is less in pp data compared to e + e - data, however it is fairly strong as compared to nucleus data. The presently used hadronization models DPM, LUND and FRITIOF do not reproduce the results fully. (orig.)

  18. Caffeine intake improves intense intermittent exercise performance and reduces muscle interstitial potassium accumulation

    DEFF Research Database (Denmark)

    Mohr, Magni; Nielsen, Jens Jung; Bangsbo, Jens

    2011-01-01

    The effect of oral caffeine ingestion on intense intermittent exercise performance and muscle interstitial ion concentrations was examined. The study consists of two studies (S1 and S2). In S1 twelve subjects completed the Yo-Yo intermittent recovery level 2 (Yo-Yo IR2) test with prior caffeine (6...... mg/kg b.w.; CAF) or placebo (PLA) intake. In S2 six subjects performed one low intense (20 W) and three intense (50 W) 3-min (separated by 5 min) one-legged knee-extension exercise bouts with (CAF) and without (CON) prior caffeine supplementation for determination of muscle interstitial K(+) and Na...

  19. Thermal Losses Effect on the Performance of an Intermittent Solar Refrigeration Cycle for Generation Phase

    International Nuclear Information System (INIS)

    Boukhchana, Yasmina; Fellah, Ali; Ben Brahim, Ammar

    2009-01-01

    In this contribution, a study of the thermal losses effect undergone by the different parts of an intermittent absorption solar refrigeration cycle using the Ammonia/Water mixture is presented. After having shown the interest of the intermittent cycles through the discussion of the problem of the adaptation of these cycles to solar energy, mass and thermal assessments for each compartment of the installation were established for the two cases without and with thermal losses. The resulting differential equations system is solved numerically. The theoretical results obtained concern the temperature variations, the vapor flow as well as the compositions of the rich and the poor solutions

  20. Protective effect of intermittent fasting on the mortality of gamma-irradiated mice

    Energy Technology Data Exchange (ETDEWEB)

    Kozubik, A.; Pospisil, M.

    1982-12-01

    The effect of 1 to 6 weeks' adaptation to intermittent fasting (alternating periods of 24 h fasting and subsequent 24 h feeding) on the manifestations of radioresistance of mice subjected to whole-body gamma-irradiation was studied. A favourable effect of this feeding regimen on the survival of irradiated animals was observed. The optimal redioprotective effect was achieved in mice adapted to intermittent fasting for 2 to 3 weeks and irradiated after 24 h of food intake. Furthermore, it was shown that the radioresistance of the adapted organism depends on the momentary state of food intake. After renewal of the normal ad libitum feeding the adaptively induced radioresistance decreases.