WorldWideScience

Sample records for intermediate polar dq

  1. Hγ Line Spectrum of Intermediate Polars

    Directory of Open Access Journals (Sweden)

    Yonggi Kim

    1998-06-01

    Full Text Available Kim & Beuermann (1995, 1996 have developed a model for the propagation of X-rays from the accreting white dwarf through the infalling material and the re-emission of the energy deposited by photo-absorption in the optical (and UV spectral range. By using this model, we calculate the profiles of the Hγ emission-line spectrum of intermediate polars. Photoabsorption of X-rays by the infalling material is the dominant process in forming the observed energy-dependent rotational modulation of the X-ray flux. X-ray and optical modulations are sensitive to model parameters in different ways. In principle, these dependencies allow us to obtain improved insight into the accretion geometry of the intermediate polars. We present results of our calculations and compare them with the Hβ line spectrum (Kim & Beuermann 1996.

  2. On the polarization of fermion in an intermediate state

    Science.gov (United States)

    Kaloshin, A. E.; Lomov, V. P.

    2017-06-01

    We show that calculation of a final fermion polarization (for a pure initial state) is equivalent to the problem of looking for complete polarization axis of bispinor. This gives the method for calculation of polarization applicable both for final and intermediate state fermions. We suggest to use fermion propagator (bare or dressed) in form of spectral representation, which gives the orthogonal off-shell energy projectors. This representation leads to covariant separation of particle and antiparticle contributions and gives a natural definition for polarization of intermediate state fermion. The most evident application is related with consistent description of t-quark polarization.

  3. Retention of intermediate polarization states in ferroelectric materials enabling memories for multi-bit data storage

    Science.gov (United States)

    Zhao, Dong; Katsouras, Ilias; Asadi, Kamal; Groen, Wilhelm A.; Blom, Paul W. M.; de Leeuw, Dago M.

    2016-06-01

    A homogeneous ferroelectric single crystal exhibits only two remanent polarization states that are stable over time, whereas intermediate, or unsaturated, polarization states are thermodynamically instable. Commonly used ferroelectric materials however, are inhomogeneous polycrystalline thin films or ceramics. To investigate the stability of intermediate polarization states, formed upon incomplete, or partial, switching, we have systematically studied their retention in capacitors comprising two classic ferroelectric materials, viz. random copolymer of vinylidene fluoride with trifluoroethylene, P(VDF-TrFE), and Pb(Zr,Ti)O3. Each experiment started from a discharged and electrically depolarized ferroelectric capacitor. Voltage pulses were applied to set the given polarization states. The retention was measured as a function of time at various temperatures. The intermediate polarization states are stable over time, up to the Curie temperature. We argue that the remarkable stability originates from the coexistence of effectively independent domains, with different values of polarization and coercive field. A domain growth model is derived quantitatively describing deterministic switching between the intermediate polarization states. We show that by using well-defined voltage pulses, the polarization can be set to any arbitrary value, allowing arithmetic programming. The feasibility of arithmetic programming along with the inherent stability of intermediate polarization states makes ferroelectric materials ideal candidates for multibit data storage.

  4. Asymmetry ratio in pair production and the degree of linearly polarized photons at intermediate energies

    CERN Document Server

    Asai, J

    1999-01-01

    In order to initiate the experiments using linearly polarized tagged photons at intermediate energies, it is imperative to know and to monitor the degree of polarization. The relationship is re-examined between the linear polarization of photons and the asymmetry ratio in pair production by such photons. An improved method is proposed in which pairs are prohibited from entering the cone region around the incident photon beam. By restricting the directions of pairs, the asymmetry ratio is much improved. (author)

  5. Intermediate polars as low-field magnetic cataclysmic variables

    International Nuclear Information System (INIS)

    Wickramasinghe, D.T.; Kinwah Wu; Ferrario, Lilia

    1991-01-01

    We present the first detailed calculations of the polarization properties of extended accretion shocks on the surface of a magnetic white dwarf where allowance is made both for field spread and for the change in shock height as a function of specific accretion rate. These results are used to show conclusively that the null detection of circular polarization in most IPs imply fields of less than 5 MG. We suggest that the X-ray properties of MCVs depends critically on the fractional area of the white-dwarf surface over which accretion occurs, and on the type of accretion (smooth or clumpy). We argue that in the known IPs, accretion occurs via a disc. The accretion flow is smooth and a strong shock forms making them a powerful source of hard X-rays. We propose that there is a new class of MCV distinct from the IPs, where the white dwarf is asynchronous and accretes without a disc in which the accretion is clumpy and the radiation is mainly in the EUV region. (author)

  6. Rare Low State of DO Dra, the Magnetic Dwarf Nova=Outbursting Intermediate Polar

    Science.gov (United States)

    Breus, Vitalii V.; Andronov, Ivan L.; Yoon, Joh-Na; Dubovský, Pavol

    2017-06-01

    DO Dra is an exotic cataclysmic variable which shows properties either of the intermediate polars, or dwarf novae. It may represent a new subclass of "magnetic Dwarf Nova=outbursting intermediate polar". Very rare low luminosity state (of =16.095±0.007) was detected on June 8/9, 2017. The light curve shows a double-humped shape with a phase of the orbital period, with two unequal maxima, arguing not only for an ellipticity effect, but for a bright spot as well. Totally, we have detected 3 lows states.

  7. Planck intermediate results. XXII. Frequency dependence of thermal emission from Galactic dust in intensity and polarization

    DEFF Research Database (Denmark)

    Cardoso, J. F.; Delabrouille, J.; Ganga, K.

    2015-01-01

    of the cosmic microwave background. We use a mask that focuses our analysis on the diffuse interstellar medium at intermediate Galactic latitudes. We determine the spectral indices of dust emission in intensity and polarization between 100 and 353 GHz, for each sky patch. Both indices are found to be remarkably......)% from 353 to 70 GHz. We discuss this result within the context of existing dust models. The decrease in p could indicate differences in polarization efficiency among components of interstellar dust (e.g., carbon versus silicate grains). Our observational results provide inputs to quantify and optimize...

  8. CXOGBS J174954.5-294335: a new deeply eclipsing intermediate polar

    Science.gov (United States)

    Johnson, Christopher B.; Torres, M. A. P.; Hynes, R. I.; Jonker, P. G.; Heinke, C.; Maccarone, T.; Britt, C. T.; Steeghs, D.; Wevers, T.; Wu, J.

    2017-04-01

    We present the results of a photometric and spectroscopic analysis of the Galactic Bulge Survey X-ray source CXOGBS J174954.5-294335 (hereafter, referred to as CX19). CX19 is a long period, eclipsing intermediate polar-type cataclysmic variable with broad, single-peaked Balmer and Paschen emission lines along with He II λ4686 and Bowen blend emission features. With coverage of one full and two partial eclipses and archival photometry, we determine the ephemeris for CX19 to be HJD(eclipse) = 2455691.8581(5) + 0.358704(2) × N. We also recovered the white dwarf spin period of Pspin = 503.32(3) s that gives a Pspin/Porb = 0.016(6), comparable to several confirmed, long-period intermediate polars. CX19 also shows a clear X-ray eclipse in the 0.3-8.0 keV range observed with Chandra. Two optical outbursts were observed lasting between 6 and 8 h (lower limits) reaching ˜1.3 mag in amplitude. The outbursts, both in duration and magnitude, the accretion disc-dominated spectra and hard X-ray emission are reminiscent of the intermediate polar V1223 Sgr sharing many of the same characteristics. If we assume a main-sequence companion, we estimate the donor to be an early G-type star and find a minimum distance of d ≈ 2.1 kpc and a 0.5-10.0 keV X-ray luminosity upper limit of 2.0 × 1033 erg s-1. Such an X-ray luminosity is consistent with a white dwarf accretor in a magnetic cataclysmic variable system. To date, CX19 is only the second deeply eclipsing intermediate polar with X-ray eclipses and the first that is optically accessible.

  9. Vimentin intermediate filaments template microtubule networks to enhance persistence in cell polarity and directed migration

    OpenAIRE

    Gan, Zhuo; Ding, Liya; Burckhardt, Christoph J.; Lowery, Jason; Zaritsky, Assaf; Sitterley, Karlyndsay; Mota, Andressa; Costigliola, Nancy; Starker, Colby G.; Voytas, Daniel F.; Tytell, Jessica; Goldman, Robert D.; Danuser, Gaudenz

    2016-01-01

    Increased expression of vimentin intermediate filaments (VIF) enhances directed cell migration, but the mechanism behind VIF’s effect on motility is not understood. VIF interact with microtubules, whose organization contributes to polarity maintenance in migrating cells. Here we characterize the dynamic coordination of VIF and microtubule networks in wounded monolayers of Retinal Pigment Epithelial cells. By genome editing we fluorescently labelled endogenous vimentin and α-...

  10. Polarization control of intermediate state absorption in resonance-mediated multi-photon absorption process

    International Nuclear Information System (INIS)

    Xu, Shuwu; Yao, Yunhua; Jia, Tianqing; Ding, Jingxin; Zhang, Shian; Sun, Zhenrong; Huang, Yunxia

    2015-01-01

    We theoretically and experimentally demonstrate the control of the intermediate state absorption in an (n + m) resonance-mediated multi-photon absorption process by the polarization-modulated femtosecond laser pulse. An analytical solution of the intermediate state absorption in a resonance-mediated multi-photon absorption process is obtained based on the time-dependent perturbation theory. Our theoretical results show that the control efficiency of the intermediate state absorption by the polarization modulation is independent of the laser intensity when the transition from the intermediate state to the final state is coupled by the single-photon absorption, but will be affected by the laser intensity when this transition is coupled by the non-resonant multi-photon absorption. These theoretical results are experimentally confirmed via a two-photon fluorescence control in (2 + 1) resonance-mediated three-photon absorption of Coumarin 480 dye and a single-photon fluorescence control in (1 + 2) resonance-mediated three-photon absorption of IR 125 dye. (paper)

  11. V2487 Oph 1998: a post nova in an intermediate polar

    Directory of Open Access Journals (Sweden)

    Hernanz Margarita

    2014-01-01

    Full Text Available V2487 Oph (Nova Oph 1998 is a classical nova that exploded in 1998. XMM-Newton observations performed between 2 and 9 years after the explosion showed emission related to restablished accretion, and indicative of a magnetic white dwarf. The spectrum looks like that of a cataclysmic variable of the intermediate polar type. Anyway, we don’t have yet a definitive confirmation of the intermediate polar character, through determination of spin and orbital periods. Although it is not the first nova exploding in a magnetic white dwarf, it is always challenging to reach explosive conditions when a standard accretion disk can’t be formed, because of the magnetic field. In addition, V2487 Oph has been the first nova where a detection of X-rays - in the host binary system – has been reported prior to its eruption, in 1990 with the ROSAT satellite. V2487 Oph has been also detected in hard X-rays with INTEGRAL/IBIS and RXTE/PCA. Last but not least, V2487 Oph has been identified as a recurrent nova in 2008, since a prior eruption in 1900 has been reported through analysis of Harvard photographic plates. Therefore, it is expected to host a massive white dwarf and be a candidate for a type Ia supernova explosion. In a recent study of the progenitors of galactic novae, it has been emphasized that V2487 Oph is an important and interesting object, "intermediate" between the "standard" classical novae and other historical and well-known recurrent novae with shorter recurrence periods. It could be that in the end there’s a continuous distribution of recurrence periods, instead of the common understanding up to now that "classical" and "recurrent" novae were quite apart (with recurrence periods of more than 104 years and less than 100years - approximately - respectively. We present the results of our campaign of several observations with XMM-Newton. The consequences for the understanding of such a puzzling object are discussed.

  12. Planck intermediate results. XXX. The angular power spectrum of polarized dust emission at intermediate and high Galactic latitudes

    Science.gov (United States)

    Planck Collaboration; Adam, R.; Ade, P. A. R.; Aghanim, N.; Arnaud, M.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Bartlett, J. G.; Bartolo, N.; Battaner, E.; Benabed, K.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Boulanger, F.; Bracco, A.; Bucher, M.; Burigana, C.; Butler, R. C.; Calabrese, E.; Cardoso, J.-F.; Catalano, A.; Challinor, A.; Chamballu, A.; Chary, R.-R.; Chiang, H. C.; Christensen, P. R.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Combet, C.; Couchot, F.; Coulais, A.; Crill, B. P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Zotti, G.; Delabrouille, J.; Delouis, J.-M.; Désert, F.-X.; Dickinson, C.; Diego, J. M.; Dolag, K.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Ducout, A.; Dunkley, J.; Dupac, X.; Efstathiou, G.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Falgarone, E.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Frejsel, A.; Galeotta, S.; Galli, S.; Ganga, K.; Ghosh, T.; Giard, M.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Guillet, V.; Hansen, F. K.; Hanson, D.; Harrison, D. L.; Helou, G.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hivon, E.; Hobson, M.; Holmes, W. A.; Huffenberger, K. M.; Hurier, G.; Jaffe, A. H.; Jaffe, T. R.; Jewell, J.; Jones, W. C.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Knox, L.; Krachmalnicoff, N.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lamarre, J.-M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Leahy, J. P.; Leonardi, R.; Lesgourgues, J.; Levrier, F.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; Maffei, B.; Maino, D.; Mandolesi, N.; Mangilli, A.; Maris, M.; Martin, P. G.; Martínez-González, E.; Masi, S.; Matarrese, S.; Mazzotta, P.; Meinhold, P. R.; Melchiorri, A.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mitra, S.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Pagano, L.; Pajot, F.; Paladini, R.; Paoletti, D.; Partridge, B.; Pasian, F.; Patanchon, G.; Pearson, T. J.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Ponthieu, N.; Popa, L.; Pratt, G. W.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Reach, W. T.; Rebolo, R.; Remazeilles, M.; Renault, C.; Renzi, A.; Ricciardi, S.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Roudier, G.; Rouillé d'Orfeuil, B.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Santos, D.; Savelainen, M.; Savini, G.; Scott, D.; Soler, J. D.; Spencer, L. D.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sunyaev, R.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Tuovinen, J.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vibert, L.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Watson, R.; Wehus, I. K.; White, M.; White, S. D. M.; Yvon, D.; Zacchei, A.; Zonca, A.

    2016-02-01

    The polarized thermal emission from diffuse Galactic dust is the main foreground present in measurements of the polarization of the cosmic microwave background (CMB) at frequencies above 100 GHz. In this paper we exploit the uniqueness of the Planck HFI polarization data from 100 to 353 GHz to measure the polarized dust angular power spectra CℓEE and CℓBB over the multipole range 40 <ℓ< 600 well away from the Galactic plane. These measurements will bring new insights into interstellar dust physics and allow a precise determination of the level of contamination for CMB polarization experiments. Despite the non-Gaussian and anisotropic nature of Galactic dust, we show that general statistical properties of the emission can be characterized accurately over large fractions of the sky using angular power spectra. The polarization power spectra of the dust are well described by power laws in multipole, Cℓ ∝ ℓα, with exponents αEE,BB = -2.42 ± 0.02. The amplitudes of the polarization power spectra vary with the average brightness in a way similar to the intensity power spectra. The frequency dependence of the dust polarization spectra is consistent with modified blackbody emission with βd = 1.59 and Td = 19.6 K down to the lowest Planck HFI frequencies. We find a systematic difference between the amplitudes of the Galactic B- and E-modes, CℓBB/CℓEE = 0.5. We verify that these general properties are preserved towards high Galactic latitudes with low dust column densities. We show that even in the faintest dust-emitting regions there are no "clean" windows in the sky where primordial CMB B-mode polarization measurements could be made without subtraction of foreground emission. Finally, we investigate the level of dust polarization in the specific field recently targeted by the BICEP2 experiment. Extrapolation of the Planck 353 GHz data to 150 GHz gives a dust power 𝒟ℓBB ≡ ℓ(ℓ+1)CℓBB/(2π) of 1.32 × 10-2 μKCMB2 over the multipole range

  13. HLA-DQ: Celiac diseasevsinflammatory bowel disease.

    Science.gov (United States)

    Bosca-Watts, Marta Maia; Minguez, Miguel; Planelles, Dolores; Navarro, Samuel; Rodriguez, Alejandro; Santiago, Jesus; Tosca, Joan; Mora, Francisco

    2018-01-07

    To determine the genetic predisposition to celiac disease (CeD) in inflammatory bowel disease (IBD) patients by quantifying the frequency of CeD-related human leucocyte antigen (HLA) (HLA-CeD: HLA-DQ2 and -DQ8) in IBD patients globally, by type of IBD and gender, and by calculating the protective/risk contribution of these haplotypes in the development of the IBD disease. We conducted a prospective study with IBD patients from our Unit. Clinical information was gathered and blood was tested for HLA-CeD. The control group was made up of unrelated Valencian organ donors. 1034 subjects were analyzed: 457 IBD [207 ulcerative coliti (UC) and 250 Crohn's disease (CD)] patients and 577 healthy controls. 39% of the controls and 34% of the patients had HLA-CeD ( P = 0.0852). HLA-DQ2 was less frequent in UC patients ( P = 0.0287), and HLA-DQ8 in CD ( P = 0.0217). In women with UC, the frequency of DQ2.5cis (DQB1*02:01-DQA1*05:01) was reduced ≥ 50% [ P = 0.0344; preventive fraction (PF) = 13%]. PFs (7%-14%) were obtained with all HLA-CeD haplotypes. HLA DQB1*02:02-DQA1*02:01 (HLA-DQ2.2) was more frequent in CD patients with respect to controls ( P = 0.001) and UC patients (etiological fraction = 15%). HLA-CeD is not more frequent in IBD patients, with an even lower frequency of HLA-DQ2 and -DQ8 in UC and CD respectively. HLA-DQ2.5 confers protection from the development of UC, especially in women, and HLA-DQ8 does so for the appearance of CD. HLA-DQ2.2 is present in 34% of the CD patients and may constitute a genetic risk factor for CD development.

  14. Planck intermediate results. XXX. The angular power spectrum of polarized dust emission at intermediate and high Galactic latitudes

    CERN Document Server

    Adam, R.; Aghanim, N.; Arnaud, M.; Aumont, J.; Baccigalupi, C.; Banday, A.J.; Barreiro, R.B.; Bartlett, J.G.; Bartolo, N.; Battaner, E.; Benabed, K.; Benoit-Levy, A.; Bernard, J.P.; Bersanelli, M.; Bielewicz, P.; Bonaldi, A.; Bonavera, L.; Bond, J.R.; Borrill, J.; Bouchet, F.R.; Boulanger, F.; Bracco, A.; Bucher, M.; Burigana, C.; Butler, R.C.; Calabrese, E.; Cardoso, J.F.; Catalano, A.; Challinor, A.; Chamballu, A.; Chary, R.R.; Chiang, H.C.; Christensen, P.R.; Clements, D.L.; Colombi, S.; Colombo, L.P.L.; Combet, C.; Couchot, F.; Coulais, A.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R.D.; Davis, R.J.; de Bernardis, P.; de Zotti, G.; Delabrouille, J.; Delouis, J.M.; Desert, F.X.; Dickinson, C.; Diego, J.M.; Dolag, K.; Dole, H.; Donzelli, S.; Dore, O.; Douspis, M.; Ducout, A.; Dunkley, J.; Dupac, X.; Efstathiou, G.; Elsner, F.; Ensslin, T.A.; Eriksen, H.K.; Falgarone, E.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A.A.; Franceschi, E.; Frejsel, A.; Galeotta, S.; Galli, S.; Ganga, K.; Ghosh, T.; Giard, M.; Giraud-Heraud, Y.; Gjerlow, E.; Gonzalez-Nuevo, J.; Gorski, K.M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Guillet, V.; Hansen, F.K.; Hanson, D.; Harrison, D.L.; Helou, G.; Henrot-Versille, S.; Hernandez-Monteagudo, C.; Herranz, D.; Hivon, E.; Holmes, W.A.; Huffenberger, K.M.; Hurier, G.; Jaffe, A.H.; Jaffe, T.R.; Jewell, J.; Jones, W.C.; Juvela, M.; Keihanen, E.; Keskitalo, R.; Kisner, T.S.; Kneissl, R.; Knoche, J.; Knox, L.; Krachmalnicoff, N.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lamarre, J.M.; Lasenby, A.; Lattanzi, M.; Lawrence, C.R.; Leahy, J.P.; Leonardi, R.; Lesgourgues, J.; Levrier, F.; Liguori, M.; Lilje, P.B.; Linden-Vornle, M.; Lopez-Caniego, M.; Lubin, P.M.; Macias-Perez, J.F.; Maffei, B.; Maino, D.; Mandolesi, N.; Mangilli, A.; Maris, M.; Martin, P.G.; Martinez-Gonzalez, E.; Masi, S.; Matarrese, S.; Mazzotta, P.; Melchiorri, A.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mitra, S.; Miville-Deschenes, M.A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J.A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C.B.; Norgaard-Nielsen, H.U.; Noviello, F.; Novikov, D.; Novikov, I.; Pagano, L.; Pajot, F.; Paladini, R.; Paoletti, D.; Partridge, B.; Pasian, F.; Patanchon, G.; Pearson, T.J.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Ponthieu, N.; Popa, L.; Pratt, G.W.; Prunet, S.; Puget, J.L.; Rachen, J.P.; Reach, W.T.; Rebolo, R.; Remazeilles, M.; Renault, C.; Renzi, A.; Ricciardi, S.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Roudier, G.; d'Orfeuil, B.Rouille; Rubino-Martin, J.A.; Rusholme, B.; Sandri, M.; Santos, D.; Savelainen, M.; Savini, G.; Scott, D.; Soler, J.D.; Spencer, L.D.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sunyaev, R.; Sutton, D.; Suur-Uski, A.S.; Sygnet, J.F.; Tauber, J.A.; Terenzi, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Tuovinen, J.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vibert, L.; Vielva, P.; Villa, F.; Wade, L.A.; Wandelt, B.D.; Watson, R.; Wehus, I.K.; White, M.; White, S.D.M.; Yvon, D.; Zacchei, A.; Zonca, A.

    2016-02-09

    The polarized thermal emission from Galactic dust is the main foreground present in measurements of the polarization of the cosmic microwave background (CMB) at frequencies above 100GHz. We exploit the Planck HFI polarization data from 100 to 353GHz to measure the dust angular power spectra $C_\\ell^{EE,BB}$ over the range $40<\\ell<600$. These will bring new insights into interstellar dust physics and a precise determination of the level of contamination for CMB polarization experiments. We show that statistical properties of the emission can be characterized over large fractions of the sky using $C_\\ell$. For the dust, they are well described by power laws in $\\ell$ with exponents $\\alpha^{EE,BB}=-2.42\\pm0.02$. The amplitudes of the polarization $C_\\ell$ vary with the average brightness in a way similar to the intensity ones. The dust polarization frequency dependence is consistent with modified blackbody emission with $\\beta_d=1.59$ and $T_d=19.6$K. We find a systematic ratio between the amplitudes of ...

  15. The hard X-ray emission spectra from accretion columns in intermediate polars

    Science.gov (United States)

    Yi, Insu; Vishniac, Ethan T.

    1994-01-01

    We consider the hard (greater than 2 keV) X-ray emission from accretion columns in an intermediate polar system, GK Per, using a simple settling solution. The rate of photon emission per logarithmic energy interval can be fitted with a power law, E(exp -gamma), with gamma approximately 2.0, in agreement with observations. This index is only weakly dependent on the mass accretion rate, dot-M, for dot-M in the range of a few times 10(exp 16-18) g/s. The peak energy of the photon spectra (after photoelectric absorption) is expected to be E(sub p) approximately (5 keV) gamma(exp -1/3) (N(sub H)/10(exp 23)/sq cm)(exp 1/3) where N(sub H) is the hydrogen column density along the line of sight. The observed spectra of GK Per and possibly of V1223 Sgr suggest N(sub H) approximately 10(exp 23)/sq cm. This large N(sub H) may be due to partially ionized preshock column material. Alternatively, we also consider absorption by the cool outer parts of an accretion disk. In this case the photoelectric absorption depth in the disk is a sensitive function of inclination. For GK Per the required inclination is approximately 83 deg. For mass accretion rates larger than a critical rate of approximately 10(exp 18) g/s, X-ray emission from the column accretion is significantly affected by radiation drag. Although the mass accretion rate increases dramatically during outbursts, the observed hard (greater than 2 keV) X-ray luminosity will not rise proportionately. The slope and peak energy of the outburst spectra are only weakly affected. We conclude that the observed X-ray spectra can be explained by this simple analytic solution and that the production of hard X-rays from the accretion shock at the magnetic poles in the intermediate polars is in general agreement with the observations. However, since the X-ray emission and absorption depend on the mass accretion rate in a complicated manner, observed hard X-ray luminosities (greater than 2 keV) are not a good indicator of the mass

  16. Grazing Eclipsing Dwarf Nova CW Monocerotis: Dwarf Nova-Type Outburst in a Possible Intermediate Polar?

    Science.gov (United States)

    Kato, Taichi; Uemura, Makoto; Kiyota, Seiichiro; Tanabe, Kenji; Koizumi, Mitsuo; Kida, Mayumi; Nishi, Yuichi; Tanaka, Sawa; Ueoka, Rie; Yasui, Hideki; Vanmunster, Tonny; Nogami, Daisaku; Yamaoka, Hitoshi

    2003-04-01

    We observed the 2002 October-November outburst of the dwarf nova CW Mon.The outburst showed a clear signature of a premaximum halt, and a more rapid decline after reaching the outburst maximum.On two separate occasions, during the premaximum stage and near the outburst maximum, shallow eclipses were recorded. This finding confirms the previously suggested possibility of the grazing eclipsing nature of this system.The separate occurrence of the eclipses and the premaximum halt can be understood as being the result of a combination of a two-step ignition of an outburst and the inside-out propagation of the heating wave.We detected a coherent short-period (0.02549d) signal on two subsequent nights around the optical maximum.This signal was likely present during the maximum phase of the 2000 January outburst.We interpret this signal as being a signature of the intermediate polar (IP) type pulses.The rather strange outburst properties, strong and hard X-ray emission, and the low luminosity of the outburst maximum might be understood as a consequence of the supposed IP nature.The ratio between the suggested spin period and the orbital period, however, is rather unusual for a system having an orbital period of ˜ 0.176 d.

  17. The All-DQ-Domain EMTP

    Directory of Open Access Journals (Sweden)

    Gibson H.M. Sianipar

    2011-04-01

    Full Text Available This paper presents an improvement to dq-domain method of calculating electromagnetic transients. The proposed methodology works on dq-domain model for all components of the power system and during all time iterations. This is a new direction distinct from the old one where the network is invariably modeled in phase-domain. By modeling the network in dq-domain there is no more problem of interfacing machine to network as usually met in the existing method as machine is modeled invariably in dq-domain. Besides eliminating the time consuming transformation procedure between dq-domain to phase-domain or visa versa the new method is able now to fully exploit the infinite stability region of the trapezoidal rule of integration. The prediction/correction procedure of the conventional dq-domain method, which is notoriously known limiting the stability region, is no longer required. Comparing simulations using the new method and ATP, one of the conventional dq-domain version, show perfect conformity for small time step. For long time step while ATP is failing, the new method still converges accurately up to Nyquist’s interval.

  18. Measuring the masses of Intermediate Polars with NuSTAR: V709 Cas, NY Lup and V1223 Sgr

    OpenAIRE

    Shaw, A. W.; Heinke, C. O.; Mukai, K.; Sivakoff, G. R.; Tomsick, J. A.; Rana, V.

    2018-01-01

    The X-ray spectra of intermediate polars can be modelled to give a direct measurement of white dwarf mass. Here we fit accretion column models to NuSTAR spectra of three intermediate polars; V709 Cas, NY Lup and V1223 Sgr in order to determine their masses. From fits to 3-78 keV spectra, we find masses of $M_{\\rm WD}=0.88^{+0.05}_{-0.04}M_{\\odot}$, $1.16^{+0.04}_{-0.02}M_{\\odot}$ and $0.75\\pm0.02M_{\\odot}$ for V709 Cas, NY Lup and V1223 Sgr, respectively. Our measurements are generally in agr...

  19. Planck intermediate results XXX. The angular power spectrum of polarized dust emission at intermediate and high Galactic latitudes

    DEFF Research Database (Denmark)

    Adam, R.; Ade, P. A. R.; Aghanim, N.

    2016-01-01

    blackbody emission with beta(d) = 1.59 and T-d = 19.6 K down to the lowest Planck HFI frequencies. We find a systematic difference between the amplitudes of the Galactic B-and E-modes, C-l(BB) = C-l(EE) = 0.5. We verify that these general properties are preserved towards high Galactic latitudes with low...... experiments. Despite the non-Gaussian and anisotropic nature of Galactic dust, we show that general statistical properties of the emission can be characterized accurately over large fractions of the sky using angular power spectra. The polarization power spectra of the dust are well described by power laws...... field recently targeted by the BICEP2 experiment. Extrapolation of the Planck 353 GHz data to 150 GHz gives a dust power D-l(BB) equivalent to l(l + 1)C-l(BB)/(2 pi) of 1.32 x 10(-2) mu K-CMB(2) over the multipole range of the primordial recombination bump (40

  20. The incidence of HLA-DQ2/DQ8 in Turkish children with celiac disease and a comparison of the geographical distribution of HLA-DQ.

    Science.gov (United States)

    Basturk, Ahmet; Artan, Reha; Yilmaz, Aygen

    2017-01-01

    Celiac disease (CD) is an auto-immune enteropathy that occurs in genetically pre-disposed people as a result of the consumption of gluten-containing foods. To identify the incidence of HLA-DQ2 and HLA-DQ8 observed in children with CD. In this study, we focused on children ranging in age from 2 to 18 years and diagnosed with celiac disease. In our patients diagnosed with CD, in addition to tissue transglutaminase antibodies (anti-tTG), we also evaluated HLA-DQ2 B1 and HLA-DQ8 B1 alleles using the method of polymerase chain reaction (PCR)/sequence-specific oligonucleotide probes (Luminex ® ). The detection of 0201/0202 for HLA-DQ2 allele and 0302 for HLA-DQ8 allele was accepted as a positive result. The mean age of our patients with celiac disease was 7.42 ±3.18 years, and the female/male ratio was 1.5/1. Seventy-six percent of our patients were HLA-DQ2 and/or HLA-DQ8 positive, 67% were HLA-DQ2 positive, and 25% were HLA-DQ8 positive. Nevertheless, 24% of them were HLA-DQ2 and HLA-DQ8 negative. The incidence of HLA-DQ2 in the control group was 18.8% with a significant difference compared to the HLA-DQ2 incidence in the patient group (67%) ( p HLA-DQ8 incidence in the control group (5.7%) was significantly lower than the incidence in the patient group (25%) ( p HLA-DQ2 and HLA-DQ8 negative, varies among different populations.

  1. Planck intermediate results. XIX. An overview of the polarized thermal emission from Galactic dust

    DEFF Research Database (Denmark)

    Cardoso, J. F.; Delabrouille, J.; Ganga, K.

    2015-01-01

    measurements toward extragalactic sources. These components bear resemblance along the Galactic plane and in some regions such as the Fan and North Polar Spur regions. The poor match observed in other regions shows, however, that dust, cosmic-ray electrons, and thermal electrons generally sample different...... in some regions of moderate hydrogen column density (NH general decrease in the dust polarization fraction with increasing column density above NH ∼ 1 × 1021 cm-2 and in particular a sharp drop...

  2. Two-Color VR CCD Photometry of the Intermediate Polar 1RXS J062518.2+733433

    Directory of Open Access Journals (Sweden)

    Yonggi Kim

    2005-09-01

    Full Text Available Results of 7 nights of CCD VR photometry of the intermediate polar 1RXS J062518.2 +733433 obtained at the Korean 1.8m telescope are reported. The corrected ephemeris for the orbital minimum is BJD (Orb.min = 2453023.6159 (42+0.1966431 (33 (E- 1735. The corrected ephemeris for the spin maximum is BJD (spin max = 2452893 .78477 (10+0.01374116815 (17 (E-15382 (cycle numbering corresponds to that of Staude et al.~2003. The variations of the shape of the individual spin variations are highly correlated in V and R. The phase of the spin maximum is found to be dependent on the orbital phase. The corresponding semi-amplitude of sinusoidal variations of phase is 0.11±0.03. This new phenomenon is explained by the changing viewing conditions of the accreting magnetic white dwarf, and should be checked in further observations this star and for other intermediate polars. To avoid influence of this effect on the analysis of the long-term spin period variations, the runs of at least one orbital period are recommended. Results of time series analysis are presented in tables.

  3. An extensive photometric study of the recently discovered intermediate polar V515 And (XSS J00564+4548)

    Science.gov (United States)

    Kozhevnikov, V. P.

    2012-05-01

    We report the results of photometry of the intermediate polar V515 And. Observations were obtained over 33 nights in 2008 and 2009. The total duration of the observations was 233 h. We clearly detected two oscillations with periods of 465.484 93 ± 0.000 07 and 488.618 22 ± 0.000 09 s, which may be the white dwarf spin period and the orbital sideband. The semi-amplitudes of the oscillations are accordingly 25 and 20 mmag. The oscillation with a period of 465.484 93 s has a stable smooth asymmetric pulse profile, whereas the pulse profile of the oscillation with a period of 488.618 22 s reveals significant changes from a quasi-sinusoidal shape to a shape somewhat resembling a light curve of an eclipsing binary. Two detected oscillations imply an orbital period of 2.73 h. V515 And is one of the most rapidly spinning intermediate polars with orbital periods less than 3 h and may not be in spin equilibrium. This could be proved by future observations. For this purpose, we obtained oscillation ephemerides with a formal shelf life of about 100 yr (a 1σ confidence level).

  4. Presence of DQ2.2 Associated with DQ2.5 Increases the Risk for Celiac Disease

    Science.gov (United States)

    Almeida, Lucas Malta; Gandolfi, Lenora; Pratesi, Riccardo; Uenishi, Rosa Harumi; de Almeida, Fernanda Coutinho; Selleski, Nicole

    2016-01-01

    Background. Celiac disease (CD) is a genetically determined immune-mediated disorder in which gluten immunogenic peptides are presented to CD4 T cells by HLA-DQ2.5, DQ8, DQ2.2, and their combinations. Our aim is to establish a risk gradient for celiac disease based on HLA-DQ profile in a brazilian representative population and the relevance of DQ2.2 in celiac disease development. Materials and Methods. 237 celiac patients and 237 controls (both groups with 164 females and 73 males) were included. All samples were tested for the presence of predisposing HLA-DQ alleles using the PCR-SSP method. Results were considered significant when p celiac patients (94.5%) and 84 controls (35.4%). Eight celiac patients (3.4%) and 38 controls (16%) disclosed only DQ2.2. Even though DQ2.2 (β2/β2 or β2/x) showed a low CD risk of 1 : 251 and 1 : 550, respectively, the genotype DQ2.5/DQ2.2 (β2/β2) showed high CD risk of 1 : 10 (p celiac disease development in at-risk population, showing that DQ2.2 variant was relevant when associated with DQ2.5. PMID:28042478

  5. Elastic scattering of polarized deuterons from 40Ca and 58Ni at intermediate energies

    International Nuclear Information System (INIS)

    Sen, N. van; Arvieux, J.; Yanlin, Y.; Gaillard, G.; Bonin, B.; Boudard, A.; Bruge, G.; Lugol, J.C.; Babinet, R.; Hasegawa, T.; Soga, F.; Cameron, J.M.; Neilson, G.C.; Sheppard, D.M.

    1985-01-01

    Angular distributions of cross section, and Asub(y) and Asub(yy) analyzing powers were measured for polarized deuteron elastic scattering from 58 Ni at 200, 400 and 700 MeV, and 40 Ca at 700 MeV. Phenomenological potentials were obtained from an optical model analysis of the data. The total reaction cross sections deduced were compared to predictions from the Glauber theory optical limit. (orig.)

  6. Probing core polarization around 78Ni: intermediate energy Coulomb excitation of 74Ni

    Directory of Open Access Journals (Sweden)

    Marchi T.

    2013-12-01

    We have recently measured the B(E2; 0+ → 2+ of the 74Ni nucleus in an intermediate-energy Coulomb excitation experiment performed at the National Superconducting Cyclotron Laboratory of the Michigan State University. The 74Ni secondary beam has been produced by fragmentation of 86Kr at 140 AMeV on a thick Be target. Selected radioactive fragments impinged on a secondary 197Au target where the measurement of the emitted γ-rays allows to extract the Coulomb excitation cross section and related structure information. Preliminary B(E2 values do not point towards an enhancement of the transition matrix element and the comparison to what was already measured by Aoi and co-workers in [1] opens new scenarios in the interpretation of the shell evolution of the Z=28 isotopes.

  7. Intermediate energy charge-exchange reactions induced by polarized 3He

    International Nuclear Information System (INIS)

    Kim, B.T.

    1998-01-01

    Spin polarization transfer is proven to be very useful in obtaining detailed information of the continuum nuclear responses. The data, taken for the (vector p,vector n) reactions, have enabled us to separate the response into the spin longitudinal and transverse components. These partial nuclear responses have been successfully used to make critical tests of nuclear structure models. In the present paper, we first summarize the results of the data and the theoretical analyses made so far. We then discuss information obtainable from the ( 3 vector He,vector t) reaction, emphasizing on the differences and similarities in comparison with the (vector p,vector n) reaction. The results of numerical calculations made for ( 3 vector He,vector t) reactions based on the microscopic distorted wave impulse approximation will also be reported. (orig.)

  8. High-risk genotypes HLA-DR3-DQ2/DR3-DQ2 and DR3-DQ2/DR4-DQ8 in co-occurrence of type 1 diabetes and celiac disease.

    Science.gov (United States)

    Smigoc Schweiger, Darja; Mendez, Andrijana; Kunilo Jamnik, Sabina; Bratanic, Nina; Bratina, Natasa; Battelino, Tadej; Brecelj, Jernej; Vidan-Jeras, Blanka

    2016-06-01

    Shared susceptibility alleles in the HLA region contribute to the co-existence of type 1 diabetes (T1D) and celiac disease (CD). The aim of our study was to identify HLA genotype variations that influence co-occurrence of T1D and CD (T1D + CD) and the order of their onset. Totally 244 patients, 67 with T1D, 68 with CD and 69 with T1D + CD, (split into "T1D first" and "CD first"), were analyzed. Control group consisted of 130 healthy unrelated individuals. Two-tailed Fisher's exact test was used for statistical analysis. The genetic background of Slovenian CD patients resembled more northern than southern European populations with DR3-DQ2/DR3-DQ2 (odds ratio [OR] = 19.68) conferring the highest risk. The T1D + CD was associated with DR3-DQ2/DR3-DQ2 (OR = 45.53) and even more with DR3-DQ2/DR4-DQ8 (OR = 93.76). DR3-DQ2/DR7-DQ2 played a neutral role in susceptibility for T1D + CD. The order of the onset of T1D or CD in patients with co-occurring diseases was not influenced by HLA risk genotype profile. DR3-DQ2/DR3-DQ2 was associated with an increased risk for developing CD in patients with T1D, whereas patients with CD carrying DR3-DQ2/DR4-DQ8 were at higher risk for developing T1D. In addition to other genetic factors including HLA class I alleles present on DR3-DQ2 extended haplotype, the second extended haplotype may moderate the risk for T1D + CD conferred by DR3-DQ2. Our results suggested that individuals carrying high-risk genotypes DR3-DQ2/DR3-DQ2 or DR3-DQ2/DR4-DQ8 would more likely develop both T1D and CD than either disease alone.

  9. IPHAS J025827.88+635234.9 and IPHAS J051814.33+294113.0: Two probable eclipsing intermediate polars

    Science.gov (United States)

    Joshi, Arti; Pandey, Jeewan Chandra

    2018-04-01

    We present photometry in the R-band and linear polarimetry of two cataclysmic variables, namely IPHAS J025827.88 + 635234.9 and IPHAS J051814.33 + 294113.0. The data were obtained from 1-m class tele-scopes of the Aryabhatta Research Institute of Observational Sciences (ARIES; Nainital, India). In addition to the deep eclipse, strong short-period oscillations are also found. We derived a pulse period of (1203 ± 25) s for IPHAS J025827.88 + 635234.9 and (3277 ± 81) s for IPHAS J051814.33 + 294113.0. The presence of both orbital and spin modulations in these systems indicate that they belong to a class of intermediate polars. The full width at half depth of the eclipse is also found to be variable from epoch to epoch for IPHAS J025827.88 + 635234.9. The presence of a variable linear polarization of high value in these two sources indicates that these systems possess a strong magnetic field.

  10. A New Intermediate Far-Field Spot Design for Polar Direct Drive at the National Ignition Facility

    Science.gov (United States)

    Cao, D.; Marozas, J. A.; Collins, T. J. B.; Radha, P. B.; McKenty, P. W.

    2015-11-01

    New far-field spot shapes were required and subsequently designed for the intermediate phase plates that will be fielded at the National Ignition Facility for polar-direct-drive laser-coupling experiments. Two-dimensional DRACO simulations using the new far-field spot design, coupled with appropriate ring energies and beam pointing angles, achieve a high neutron yield-over-clean (YOC) ratio with a clean hot-spot radius averaging 50 μm and a convergence ratio (CR) above 17 when performed with a 1300- μm plastic shell target driven by a 700-kJ double-picket pulse. This meets the original design objectives of maintaining a clean hot spot with a CR of 17. The presented far-field spot shapes are based on an ignition polar-direct-drive configuration modeled with the iSNB nonlocal thermal transport model. In addition, the use of Multi-FM during the first two pickets does not hinder performance, but instead slightly improves the neutron yield. This material is based upon work supported by the Department of Energy National Nuclear Security Administration under Award Number DE-NA0001944.

  11. Elastic scattering of polarized protons from 3He at intermediate energies

    International Nuclear Information System (INIS)

    Hasell, D.K.; Bracco, A.; Gubler, H.P.

    1982-09-01

    Using the polarized proton beam facility of the TRIUMF cyclotron, differential cross sections and analyzing powers have been measured in the angular range 20 0 - 150 0 c.m. for proton elastic scattering from 3 He at incident proton energies of 200, 300, 415 and 515 MeV. The differential cross sections exhibit a minimum at t = -0.33 (GeV/c) 2 which becomes more pronounced with increasing energy. There is evidence for the onset of a second minimum corresponding to the interference between double and triple scattering amplitudes. Large analyzing powers are observed at the lower energies. The data from the present analysis, together with data obtained from the literature in the energy range 100-1000 MeV, have been analyzed within the framework of the Glauber multiple scattering formalism. Nucleon-nucleon scattering parameters were taken from a global phase shift analysis of nucleon-nucleon elastic scattering data. Reasonable agreement with the data is obtained

  12. RXTE determination of the intermediate polar status of XSS J00564+4548, IGR J17195-4100, and XSS J12270-4859

    Science.gov (United States)

    Butters, O. W.; Norton, A. J.; Hakala, P.; Mukai, K.; Barlow, E. J.

    2008-08-01

    Aims: We determine the nature of the intermediate polar candidates XSS J00564+4548, IGR J17195-4100, and XSS J12270-4859. Methods: Pointed RXTE observations searched for intermediate polar characteristics in these candidate systems. Results: XSS J00564+4548 exhibits a period of 465.68 ± 0.07 s, which we interpret as the spin period, an energy dependent modulation depth, and a spectrum that is fit by a 22 keV photoelectrically absorbed bremsstrahlung with an iron line profile. IGR J17195-4100 shows several candidate periodicities and a spectrum that is fit by a power law with an iron line. XSS J12270-4859 exhibits a candidate spin period of 859.57 ± 0.64 s and a spectrum that is fit by a power law with no evidence of an iron line. Conclusions: XSS J00564+4548 is confirmed to be an intermediate polar. IGR J17195-4100 and XSS J12270-4859 both show some properties of intermediate polars, but cannot be confirmed as definite members of the class here.

  13. HLA-DQ2 and -DQ8 haplotypes frequency and diagnostic utility in celiac disease patients of Gaza strip, Palestine.

    Science.gov (United States)

    Ayesh, Basim M; Zaqout, Eman Kh; Yassin, Maged M

    2017-11-15

    Celiac disease (CD) diagnosis can be established by serological and small bowel biopsy (SBB), while absence of HLA-DQ2 and -DQ8 haplotypes excludes the disease. The present study aims at evaluating the diagnosis of a representative sample of pediatric and adult CD patients of Gaza strip in light of DQ2 and DQ8 haplotypes expression. Unrelated CD patients (n = 101) and matched healthy controls (n = 97) were genotyped for DQA1*05, DQB1*02 and DQB1*03:02 alleles by allele-specific real-time PCR. The diagnosis was re-evaluated according to the patient laboratory tests and HLA-DQ genotype. The diagnosis of 35 patients who have been managed for CD could not be confirmed. Twenty-five of them were diagnosed upon their clinical presentation only. The remaining were either negative for serological and SBB tests or negative for HLA-DQ haplotypes. The HLA-DQ alleles were negative in 4 SBB and one Anti-EMA positive patients. The frequency of DQ2 and DQ8 haplotypes among the remaining 65 confirmed cases was 70.8 and 15.4%, respectively, compared to 17.5 and 27.8% in the controls. The DQB1*02 allele was the most common in the cases (84.6%) followed by DQA1*05 allele (80%) and DQB1*03:02 allele (20%). The DQA1*05 allele was commonest in the control group (54.6%) followed by DQB1*02 allele (42.3%) and DQB1*03:02 allele (28.9%). Absence of HLA-DQ2 and HLA-DQ8 genotyping in the workup of patients may result in CD misdiagnosis, particularly in a setting with poor histopathological diagnostic capacity.

  14. Allele and haplotype frequencies for HLA-DQ in Iranian celiac disease patients

    Science.gov (United States)

    Rostami-Nejad, Mohammad; Romanos, Jihane; Rostami, Kamran; Ganji, Azita; Ehsani-Ardakani, Mohammad Javad; Bakhshipour, Ali-Reza; Zojaji, Homayoun; Mohebbi, Seyed Reza; Zali, Mohammad-Reza; Wijmenga, Cisca

    2014-01-01

    AIM: To assess the distribution of human leukocyte antigen (HLA)-DQ2 and -DQ8 in Iranian celiac disease (CD) patients and compare them to healthy Iranian controls. METHODS: To predict the HLA-DQA1 and -DQB1 genes, we used six previously reported HLA-tagging single nucleotide polymorphism to determine HLA genotypes in 59 Iranian patients with ‘biopsy-confirmed’ CD and in 151 healthy Iranian individuals. To test the transferability of the method, 50 cases and controls were also typed using a commercial kit that identifies individual carriers of DQ2, DQ7 and DQ8 alleles. RESULTS: In this pilot study 97% of CD cases (n = 57) and 58% of controls (n = 87) were carriers of HLA-DQ2 and/or HLA-DQ8 heterodimers, either in the homozygous or heterozygous state. The HLA-DQ pattern of these 57 CD patients: heterozygous DQ2.2 (n = 14) and homozygous DQ2.2 (n = 1), heterozygous DQ2.5 (n = 33) and homozygous DQ2.5 (n = 8), heterozygous DQ8 (n = 13) and homozygous DQ8 (n = 2). Two CD patients were negative for both DQ2 and DQ8 (3%). CONCLUSION: The prevalence of DQ8 in our CD population was higher than that reported in other populations (25.4%). As reported in other populations, our results underline the primary importance of HLA-DQ alleles in the Iranian population’s susceptibility to CD. PMID:24876751

  15. Planck intermediate results. XX. Comparison of polarized thermal emission from Galactic dust with simulations of MHD turbulence

    DEFF Research Database (Denmark)

    Cardoso, J. F.; Delabrouille, J.; Ganga, K.

    2015-01-01

    Polarized emission observed by Planck HFI at 353 GHz towards a sample of nearby fields is presented, focusing on the statistics of polarization fractions p and angles ψ. The polarization fractions and column densities in these nearby fields are representative of the range of values obtained over...... the whole sky. We find that: (i) the largest polarization fractions are reached in the most diffuse fields; (ii) the maximum polarization fraction pmax decreases with column density NH in the more opaque fields with NH> 1021 cm-2; and (iii) the polarization fraction along a given line of sight is correlated...... of the maximum polarization fraction with column density in nearby molecular clouds is well reproduced in the simulations, indicating that it is essentially due to the turbulent structure of the magnetic field: an accumulation of variously polarized structures along the line of sight leads to such an anti...

  16. Planck intermediate results. XXI. Comparison of polarized thermal emission from Galactic dust at 353 GHz with interstellar polarization in the visible

    DEFF Research Database (Denmark)

    Cardoso, J.F.; Delabrouille, J.; Ganga, K.

    2015-01-01

    ) in the visible with that in the submillimetre. For those lines of sight through the diffuse interstellar medium with comparable values of the estimated column density and polarization directions close to orthogonal, we correlate properties in the submillimetre and visible to find two ratios, RS/V = (PS......The Planck survey provides unprecedented full-sky coverage of the submillimetre polarized emission from Galactic dust. In addition to the information on the direction of the Galactic magnetic field, this also brings new constraints on the properties of dust. The dust grains that emit the radiation...... seen by Planck in the submillimetre also extinguish and polarize starlight in the visible. Comparison of the polarization of the emission and of the interstellar polarization on selected lines of sight probed by stars provides unique new diagnostics of the emission and light scattering properties...

  17. Mechanism of ({sup 14}N, {sup 12}B) reactions at intermediate energy leading to large spin-polarization of {sup 12}B

    Energy Technology Data Exchange (ETDEWEB)

    Mitsuoka, Shin-ichi [Osaka Univ., Ibaraki (Japan). Research Center for Nuclear Physics; Shimoda, Tadashi; Miyatake, Hiroari [and others

    1996-05-01

    To study mechanisms of the ({sup 14}N, {sup 12}B) reactions at intermediate energies, double differential cross section and nuclear spin-polarization of the {sup 12}B projectile-like fragments have been measured as a function of longitudinal momentum in the angular range of 0deg - 9deg. Large spin-polarization of the reaction products {sup 12}B has been observed in the {sup 9}Be({sup 14}N, {sup 12}B) reaction at 39.3 MeV/u. The momentum distributions at forward angles exhibit characteristic features which can not be understood by the current projectile fragmentation picture. It is shown that by assuming the existence of direct two-proton transfer process in addition to the fragmentation process, both the cross section and polarization of {sup 12}B fragments are successfully explained. The target and incident energy dependence of the momentum distribution are also explained reasonably. (author)

  18. Planck intermediate results XXXIII. Signature of the magnetic field geometry of interstellar filaments in dust polarization maps

    DEFF Research Database (Denmark)

    Ade, P. A. R.; Aghanim, N.; Alves, M. I. R.

    2016-01-01

    Planck observations at 353 GHz provide the first fully sampled maps of the polarized dust emission towards interstellar filaments and their backgrounds (i.e., the emission observed in the surroundings of the filaments). The data allow us to determine the intrinsic polarization properties of the f......Planck observations at 353 GHz provide the first fully sampled maps of the polarized dust emission towards interstellar filaments and their backgrounds (i.e., the emission observed in the surroundings of the filaments). The data allow us to determine the intrinsic polarization properties...

  19. dq-Frame Cascaded Delayed Signal Cancellation-Based PLL

    DEFF Research Database (Denmark)

    Golestan, Saeed; Ramezani, Malek; Guerrero, Josep M.

    2015-01-01

    operator as the pre-filtering stage of PLL, and little work has been conducted on its application as the in-loop filtering stage of PLL. This paper provides a detailed analysis and design of dqCDSC-PLL (PLL with in-loop dq-frame CDSC operator). The study is started with an overview of this PLL....... A systematic design method to fine tune its control parameters is then proposed. The performance of the dqCDSC-PLL under different grid scenarios is then evaluated in details. It is then shown that how using the proportional-integral derivative controller as the loop filter can improve the response time of dq...

  20. Binding of peptides to HLA-DQ molecules: peptide binding properties of the disease-associated HLA-DQ(alpha 1*0501, beta 1*0201) molecule

    DEFF Research Database (Denmark)

    Johansen, B H; Buus, S; Vartdal, F

    1994-01-01

    Peptide binding to DQ molecules has not previously been described. Here we report a biochemical peptide-binding assay specific for the DQ2 [i.e. DQ(alpha 1*0501, beta 1*0201)] molecule. This molecule was chosen since it shows a strong association to diseases such as celiac disease and insulin...

  1. Different binding motifs of the celiac disease-associated HLA molecules DQ2.5, DQ2.2, and DQ7.5 revealed by relative quantitative proteomics of endogenous peptide repertoires

    DEFF Research Database (Denmark)

    Bergseng, Elin; Dørum, Siri; Arntzen, Magnus Ø.

    2014-01-01

    Celiac disease is caused by intolerance to cereal gluten proteins, and HLA-DQ molecules are involved in the disease pathogenesis by presentation of gluten peptides to CD4+ T cells. The α- or β-chain sharing HLA molecules DQ2.5, DQ2.2, and DQ7.5 display different risks for the disease...... established binding motifs. The binding motif of DQ2.2 was strikingly different from that of DQ2.5 with position P3 being a major anchor having a preference for threonine and serine. This is notable as three recently identified epitopes of gluten recognized by T cells of DQ2.2 celiac patients harbor serine...... at position P3. This study demonstrates that relative quantitative comparison of endogenous peptides sampled from our protein metabolism by HLA molecules provides clues to understand HLA association with disease....

  2. A peptide-binding assay for the disease-associated HLA-DQ8 molecule

    DEFF Research Database (Denmark)

    Straumfors, A; Johansen, B H; Vartdal, F

    1998-01-01

    The study of peptide binding to HLA class II molecules has mostly concentrated on DR molecules. Since many autoimmune diseases show a primary association to particular DQ molecules rather than DR molecules, it is also important to study the peptide-binding properties of DQ molecules. Here we report...... a biochemical peptide-binding assay for the type I diabetes-associated DQ8, i.e. DQ (alpha1*0301, beta1*0302), molecule. Affinity-purified DQ8 molecules were tested in peptide-binding assays using a radiolabelled influenza haemagglutinin (Ha) peptide encompassing positions 255-271(Y) as an indicator peptide...... of 43 peptides of different lengths and sequences. The DQ8 molecules showed a different pattern of peptide binding compared to a previously studied DQ2 molecule. Peptides derived from thyroid peroxidase, HLA-DQ(alpha1*0301), HLA-DQ(alpha1*0302), retinol receptor and p21ras were among the high...

  3. Planck intermediate results: XLIV. Structure of the Galactic magnetic field from dust polarization maps of the southern Galactic cap

    DEFF Research Database (Denmark)

    Aghanim, N.; Alves, M. I R; Arzoumanian, D.

    2016-01-01

    Using data from the Planck satellite, we study the statistical properties of interstellar dust polarization at high Galactic latitudes around the south pole (b < −60°). Our aim is to advance the understanding of the magnetized interstellar medium (ISM), and to provide a modelling framework of the...... is an important step towards a model that can be used to assess the accuracy of component-separation methods in present and future CMB experiments designed to search the B mode CMB polarization from primordial gravity waves....

  4. A peptide-binding assay for the disease-associated HLA-DQ8 molecule

    DEFF Research Database (Denmark)

    Straumfors, A; Johansen, B H; Vartdal, F

    1998-01-01

    The study of peptide binding to HLA class II molecules has mostly concentrated on DR molecules. Since many autoimmune diseases show a primary association to particular DQ molecules rather than DR molecules, it is also important to study the peptide-binding properties of DQ molecules. Here we report...... of 43 peptides of different lengths and sequences. The DQ8 molecules showed a different pattern of peptide binding compared to a previously studied DQ2 molecule. Peptides derived from thyroid peroxidase, HLA-DQ(alpha1*0301), HLA-DQ(alpha1*0302), retinol receptor and p21ras were among the high...

  5. Fequency distribution of HLA DQ2 and DQ8 in celiac patients and first-degree relatives in Recife, northeastern Brazil

    Directory of Open Access Journals (Sweden)

    Margarida Maria Castro-Antunes

    2011-01-01

    Full Text Available AIMS: The aim of this study was to evaluate the frequencies of the HLA genotypes DQ2 and DQ8 and the alleles A1*05, A1*0201, B1*0201 and B1*0302 in individuals with celiac disease in Recife, northeastern Brazil. METHODS: HLA DQ2 and DQ8 genotyping was performed for 73 individuals with celiac disease and 126 first-degree relatives with negative transglutaminase serology. The alleles DQA1*05, DQA1*0201, DQB1*02 and DQB1*0302 were identified by sequencing using specific primers and the EU-DQ kit from the Eurospital Laboratory, Trieste, Italy and double-checked by the All Set SPP kit (Dynal. RESULTS: Among the 73 cases, 50 (68.5% had the genotype DQ2, 13 (17.8% had DQ8, 5 (6.8% had DQ2 and DQ8, and 5 did not have any of these genotypes. Among the 5 negative individuals, four had the B1*02 allele and one did not have any of the alleles studied. B1*02 was the most frequent allele in both groups (94% in the patients and 89% in the control relatives. CONCLUSIONS: In this study, celiac disease was associated with the genotypes DQ2 and DQ8. DQ2 predominated, but the distribution of the frequencies was different from what has been found in European populations and was closer to what has been found in the Americas. The high frequencies of the HLA genotypes DQ2 and DQ8 that were found in first-degree relatives would make it difficult to use these HLA genotypes for routine diagnosis of celiac disease in this group.

  6. Polarization phenomena in nucleon-nucleon scattering at intermediate and high energies including the present status of dibaryons

    Energy Technology Data Exchange (ETDEWEB)

    Yokosawa, A.

    1985-01-01

    We review experimental results concerning polarization phenomena in nucleon-nucleon scattering in which both the elastic scattering and hadron-production reaction are included. We also present summary of S = 0 dibaryon resonances and candidates by reviewing experimental data in the nucleon-nucleon system, ..gamma..d channel, ..pi..d elastic scattering, pp ..-->.. ..pi..d channel, deuteron break-up reactions, and narrow structures in missing-mass spectra. 93 refs., 26 figs.

  7. Study of nuclear isovector spin responses from polarization transfer in (p,n) reactions at intermediate energies

    International Nuclear Information System (INIS)

    Wakasa, Tomotsugu

    1997-01-01

    We have measured a complete set of polarization transfer observables has been measured for quasi-free (p vector, n vector) reactions on 2 H, 6 Li, 12 C, 40 Ca, and 208 Pb at a bombarding energy of 346MeV and a laboratory scattering angle of 22deg (q=1.7 fm -1 ). The polarization transfer observables for all five targets are remarkably similar. These polarization observables yield separated spin-longitudinal (σ·q) and spin-transverse (σxq) nuclear responses. These results are compared to the spin-transverse responses measured in deep-inelastic electron scattering as well as to nuclear responses based on the random phase approximation. Such a comparison reveals an enhancement in the (p vector, n vector) spin-transverse channel, which masks the effect of pionic correlations in the response ratio. Second, the double differential cross sections at θ lab between 0deg and 12.3deg and the polarization transfer D NN at 0deg for the 90 Zr(p,n) reaction are measured at a bombarding energy of 295MeV. The Gamow-Teller(GT) strength B(GT) in the continuum deduced from the L=0 cross section is compared both with the perturbative calculation by Bertsch and Hamamoto and with the second-order random phase approximation calculation by Drozdz et al. The sum of B(GT) values up to 50MeV excitation becomes S β- =28.0±1.6 after subtracting the contribution of the isovector spin-monopole strength. This S β- value of 28.0±1.6 corresponds to about (93±5)% of the minimum value of the sum-rule 3(N-Z)=30. Last, first measurements of D NN (0deg) for (p vector, n vector) reactions at 295MeV yield large negative values up to 50MeV excitation for the 6 Li, 11 B, 12 C, 13 C(p vector, n vector) reactions. DWIA calculations using the Franey and Love (FL) 270MeV interaction reproduce differential cross sections and D NN (0deg) values, while the FL 325MeV interaction yield D NN (0deg) values less negative than the experimental values. (J.P.N.)

  8. Detailed EXOSAT and optical observations of the intermediate polar 3A0729+103: discovery of two medium energy X-ray emission regions

    International Nuclear Information System (INIS)

    McHardy, I.M.; Pye, J.P.; Fairall, A.P.; Menzies, J.W.

    1987-01-01

    EXOSAT observations of the intermediate polar cataclysmic variable 3A0729+103 reveal a strong orbital modulation, with the 2-4KeV X-rays being significantly more modulated than the 4-6keV X-rays, indicative of photoelectric absorption. The 913 second modulation which is very prominent in the optical light curve, is weakly detected in the medium-energy X-ray light curve, confirming that it represents the white dwarf spin period. These observations are well explained by a combination of two sources of medium-energy X-ray emission. The presence of two emission regions is also clearly seen in the optical spectroscopy, particularly in the intensity of the He II4686 line which has two peaks during the orbit. The authors identify the two optical emission regions with the two X-ray emission regions. (author)

  9. Polarized matrix infrared spectra of cyclopentadienone: observations, calculations, and assignment for an important intermediate in combustion and biomass pyrolysis.

    Science.gov (United States)

    Ormond, Thomas K; Scheer, Adam M; Nimlos, Mark R; Robichaud, David J; Daily, John W; Stanton, John F; Ellison, G Barney

    2014-01-30

    A detailed vibrational analysis of the infrared spectra of cyclopentadienone (C5H4═O) in rare gas matrices has been carried out. Ab initio coupled-cluster anharmonic force field calculations were used to guide the assignments. Flash pyrolysis of o-phenylene sulfite (C6H4O2SO) was used to provide a molecular beam of C5H4═O entrained in a rare gas carrier. The beam was interrogated with time-of-flight photoionization mass spectrometry (PIMS), confirming the clean, intense production of C5H4═O. Matrix isolation infrared spectroscopy coupled with 355 nm polarized UV for photoorientation and linear dichroism experiments was used to determine the symmetries of the vibrations. Cyclopentadienone has 24 fundamental vibrational modes, Γvib = 9a1 ⊕ 3a2 ⊕ 4b1 ⊕ 8b2. Using vibrational perturbation theory and a deperturbation-diagonalization method, we report assignments of the following fundamental modes (cm(-1)) in a 4 K neon matrix: the a1 modes of X̃ (1)A1 C5H4═O are found to be ν1 = 3107, ν2 = (3100, 3099), ν3 = 1735, ν5 = 1333, ν7 = 952, ν8 = 843, and ν9 = 651; the inferred a2 modes are ν10 = 933, and ν11 = 722; the b1 modes are ν13 = 932, ν14 = 822, and ν15 = 629; the b2 fundamentals are ν17 = 3143, ν18 = (3078, 3076) ν19 = (1601 or 1595), ν20 = 1283, ν21 = 1138, ν22 = 1066, ν23 = 738, and ν24 = 458. The modes ν4 and ν6 were too weak to be detected, ν12 is dipole-forbidden and its position cannot be inferred from combination and overtone bands, and ν16 is below our detection range (calculations, assigned as two quantum transitions, and used to assign some of the weak and infrared inactive fundamental vibrations.

  10. The production and crystallization of the human leukocyte antigen class II molecules HLA-DQ2 and HLA-DQ8 complexed with deamidated gliadin peptides implicated in coeliac disease

    Energy Technology Data Exchange (ETDEWEB)

    Henderson, Kate N.; Reid, Hugh H.; Borg, Natalie A.; Broughton, Sophie E.; Huyton, Trevor [The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800 (Australia); Anderson, Robert P. [Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3050 (Australia); Department of Gastroenterology, The Royal Melbourne Hospital, Grattan Street, Parkville, Victoria 3050 (Australia); McCluskey, James [Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010 (Australia); Rossjohn, Jamie, E-mail: jamie.rossjohn@med.monash.edu.au [The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800 (Australia)

    2007-12-01

    The production and crystallization of human leukocyte antigen class II molecules HLA-DQ2 and HLA-DQ8 in complex with deamidated gliadin peptides is reported. Crystals of HLA-DQ2{sup PQPELPYPQ} diffracted to 3.9 Å, while the HLA-DQ8{sup EGSFQPSQE} crystals diffracted to 2.1 Å, allowing structure determination by molecular replacement. The major histocompatibility complex (MHC) class II molecules HLA-DQ2 and HLA-DQ8 are key risk factors in coeliac disease, as they bind deamidated gluten peptides that are subsequently recognized by CD4{sup +} T cells. Here, the production and crystallization of both HLA-DQ2 and HLA-DQ8 in complex with the deamidated gliadin peptides DQ2 α-I (PQPELPYPQ) and DQ8 α-I (EGSFQPSQE), respectively, are reported.

  11. Limited role of HLA DQ2/8 genotyping in diagnosing coeliac disease.

    Science.gov (United States)

    Paul, Siba P; Hoghton, Matthew; Sandhu, Bhupinder

    2017-02-01

    The European guidelines for diagnosing coeliac disease in children were revised in 2012. These recommend that in symptomatic children, a diagnosis of coeliac disease can be made without small-bowel biopsies provided their anti-tissue transglutaminase (anti-tTG) titre is >10 times of upper-limit-of-normal (>10×ULN) and anti-endomysial antibody is positive. In order to firm up the diagnosis in these children with very high anti-tTG titre, HLA-DQ2/DQ8 should be checked and be positive. Approximately 25-40% of white Caucasian population has HLA-DQ2/DQ8 haplotype. However, only 0.1-1% of the population will develop coeliac disease. Therefore, HLA-DQ2/DQ8 testing must not be done to 'screen' or 'diagnose' children with coeliac disease. Its use by paediatricians should be limited to children with anti-tTG>10×ULN, where the diagnosis of coeliac disease is being made on serology alone. A review of case referrals made to a tertiary paediatric gastroenterology centre in Southwest England demonstrated that HLA-DQ2/DQ8 testing is being requested inappropriately both in primary and secondary care suggesting a poor understanding of its role in diagnosis of coeliac disease. This article aims to clarify the role of HLA-DQ2/DQ8 testing for clinicians working in non-specialist settings.

  12. Binding of peptides to HLA-DQ molecules: peptide binding properties of the disease-associated HLA-DQ(alpha 1*0501, beta 1*0201) molecule

    DEFF Research Database (Denmark)

    Johansen, B H; Buus, S; Vartdal, F

    1994-01-01

    Peptide binding to DQ molecules has not previously been described. Here we report a biochemical peptide-binding assay specific for the DQ2 [i.e. DQ(alpha 1*0501, beta 1*0201)] molecule. This molecule was chosen since it shows a strong association to diseases such as celiac disease and insulin......-dependent diabetes mellitus. Initially we radiolabelled some selected peptides and tested them for binding to affinity-purified DQ2 molecules. One of the peptides, a Mycobacterium bovis (MB) 65 kDa 243-255Y peptide, displayed a good signal-to-noise ratio and was thus chosen as an indicator peptide in the DQ2 binding...... to DQ2 was specific, as shown in inhibition experiments with a panel of 47 peptides, differing in length, sequence, and origin. The binding of peptides to DR3 was tested in a similar assay with a Mycobacterium tuberculosis 65 kDa 3-13 peptide as the binding indicator. DQ2 and DR3 molecules bound...

  13. HLA-DQ genetic risk gradient for type 1 diabetes and celiac disease in northwestern Mexico.

    Science.gov (United States)

    Mejía-León, M E; Ruiz-Dyck, K M; Calderón de la Barca, A M

    2015-01-01

    Type 1 diabetes (T1D) and celiac disease (CD) are the 2 most common autoimmune childhood diseases that share their HLA-DQ2 and DQ8 genetic origin. There has currently been an increase in both diseases worldwide. In children from the low-population State of Sonora (15 inhabitants/km(2)) in north-western Mexico, there is no information on their genetic risk or the distribution of the related alleles in the general population. To compare the HLA-DQ allele frequency in a representative sample of newborns from Sonora with that of T1D and CD patients to determine the risk gradient, and to identify the presence of celiac autoimmunity in the T1D group. The study included 397 Sonoran newborns, with 44 cases of T1D, and 25 CD cases. The CD and T1D cases were clinically diagnosed by specialists at the Hospital Infantil del Estado de Sonora, and the autoantibodies were determined by ELISA. Whole blood was collected, gDNA was extracted, and HLA-DQ2 and DQ8 were typed by PCR-SSP. The risk gradient was calculated by comparing the allele frequencies of the cases with those of the newborns. The Sonoran HLA-DQ risk heterodimer proportion was 16.1% for HLA-DQ2 and 13.6% for HLA-DQ8, with an HLA-DQ2:HLA-DQ8 ratio of 1.2:1. The DQ8/DQ2 genotype represented a 1:14 risk for T1D, whereas the DQ8/DQB1*0201 combination showed a 1:6 risk for CD. The prevalence of CD autoimmunity in T1D children was 7%. The Sonoran population has a distinctive HLA-DQ allele distribution due to its ancestry. The HLA-DQ8 combinations with DQ2 or one of its alleles conferred the highest risk for both diseases, and T1D and CD frequently appear together. Copyright © 2015 Asociación Mexicana de Gastroenterología. Published by Masson Doyma México S.A. All rights reserved.

  14. Collagenous Enteritis is Unlikely a Form of Aggressive Celiac Disease Despite Sharing HLA-DQ2/DQ8 Genotypes.

    Science.gov (United States)

    Kung, Vanderlene Liu; Liu, Ta-Chiang; Ma, Changqing

    2018-04-01

    Collagenous enteritis is an uncommon small intestinal injury pattern with unclear pathogenesis. While it has been speculated that collagenous enteritis represents a form of refractory celiac disease, recent clinical studies suggest a potential link to exposure to the antihypertensive medication olmesartan. Here we hypothesized that the pathogenesis of collagenous enteritis involves both genetic and environmental factors. All subjects with biopsy-proven collagenous enteritis diagnosed between 2002 and 2015 were identified from 2 tertiary care medical centers. Human leukocyte antigen (HLA)-DQ genotyping was performed by polymerase chain reaction on archived tissue. Celiac disease serology, past medical history, medications, smoking history, demographics, histology, clinical management, and follow-up were recorded. A total of 32 subjects were included. In contrast to celiac disease, subjects with collagenous enteritis were mostly elderly (median age at diagnosis, 69 y; range, 33 to 84 y). Seventy percent of collagenous enteritis subjects harbored celiac disease susceptibility alleles HLA-DQ2/DQ8; however, only 1 subject had elevated serum levels of celiac disease-associated autoantibodies while on a gluten-containing diet. Furthermore, 56% of subjects were taking nonsteroidal anti-inflammatory drugs, 36% proton-pump inhibitors, 28% statins, and 32% olmesartan at the time of diagnosis. Discontinuation of olmesartan and treatments with steroids and/or gluten-free diet resulted in symptomatic and histologic improvement. Neither lymphoma nor collagenous enteritis-related death was seen in this cohort. Therefore, while collagenous enteritis shares similar HLA genotypes with celiac disease, the difference in demographics, the lack of celiac disease-associated autoantibodies, and potential link to medications as environmental triggers suggest the 2 entities are likely distinct in pathogenesis.

  15. Distributed Data Management on the Petascale using Heterogeneous Grid Infrastructures with DQ2

    CERN Document Server

    Branco, M; Salgado, P; Lassnig, M

    2008-01-01

    We describe Don Quijote 2 (DQ2), a new approach to the management of large scientific datasets by a dedicated middleware. This middleware is designed to handle the data organisation and data movement on the petascale for the High-Energy Physics Experiment ATLAS at CERN. DQ2 is able to maintain a well-defined quality of service in a scalable way, guarantees data consistency for the collaboration and bridges the gap between EGEE, OSG and NorduGrid infrastructures to enable true interoperability. DQ2 is specifically designed to support the access and management of large scientific datasets produced by the ATLAS experiment using heterogeneous Grid infrastructures. The DQ2 middleware manages those datasets with global services, local site services and enduser interfaces. The global services, or central catalogues, are responsible for the mapping of individual files onto DQ2 datasets. The local site services are responsible for tracking files available on-site, managing data movement and guaranteeing consistency of...

  16. Mapping of HLA- DQ haplotypes in a group of Danish patients with celiac disease

    DEFF Research Database (Denmark)

    Lund, Flemming; Hermansen, Mette N; Pedersen, Merete F

    2015-01-01

    BACKGROUND: A cost-effective identification of HLA- DQ risk haplotypes using the single nucleotide polymorphism (SNP) technique has recently been applied in the diagnosis of celiac disease (CD) in four European populations. The objective of the study was to map risk HLA- DQ haplotypes in a group...... of Danish CD patients using the SNP technique. METHODS: Cohort A: Among 65 patients with gastrointestinal symptoms we compared the HLA- DQ2 and HLA- DQ8 risk haplotypes obtained by the SNP technique (method 1) with results based on a sequence specific primer amplification technique (method 2......) and a technique used in an assay from BioDiagene (method 3). Cohort B: 128 patients with histologically verified CD were tested for CD risk haplotypes (method 1). Patients with negative results were further tested for sub-haplotypes of HLA- DQ2 (methods 2 and 3). RESULTS: Cohort A: The three applied methods...

  17. Time-resolved spectrophotometry of HZ Herculis and DQ Herculis

    International Nuclear Information System (INIS)

    Chanan, G.A.

    1978-01-01

    The image-tube scanner at the 3 m telescope at Lick Observatory was employed to study the spectral changes which occur during the pulse period in the optical pulsars HZ Herculis (1.2 s period) and DQ Herculis (71 s period). The data acquisition is described and the tools needed for the data analysis developed. Then the results of the observations are presented. In the case of HZ Herculis (Hercules X-1), observations cover the binary phase interval 0.18 to 0.26 and are concerned only with those pulsations that have been shown (Middleditch and Nelson, 1976) to originate at the x-ray heated surface of the Roche lobe filling companion of the neutron star. It is found that these pulsations are distributed throughout the optical continuum. Observations appear to agree at least qualitatively with the numerical results of other investigators. The observations of DQ Herculis cover one full binary cycle, excluding eclipse. Again pulsations are found distributed throughout the continuum with generally weak wavelength dependence. However, in this case the emission line lambda 4686 (He II) is more strongly modulated than the underlying continuum and exhibits an unexpected effect: The pulse phase increases rapidly with increasing wavelength across the line. This effect can be understood in terms of a simple model in which the pulsations arise at the inner edge of the accretion disk, excited by radiation which originates at hot spots on the white dwarf and which sweeps around the disk as the degenerate star rotates. A similar model in which the pulsations arise predominantly from the back half of the surface of the disk appears in several respects to be more promising. The evident relation between the phase shift across the emission line and the so-called 360 0 phase shift through eclipse, discovered by Warner et al. (1972) is also discussed

  18. Molecular basis for HLA-DQ associations with IDDM.

    Science.gov (United States)

    Nepom, G T; Kwok, W W

    1998-08-01

    Autoimmune diabetes is the clinical end point for a sequential cascade of immunologic events that occur in a genetically susceptible individual. Structural and functional analysis of the HLA class II susceptibility genes in IDDM suggests likely molecular mechanisms for several of the key steps in this cascade of autoimmune events. We outline a pathway in which the HLA-DQ genes associated with IDDM bias the immunologic repertoire toward autoimmune specificities, creating an autoimmune-prone individual, followed by amplification and triggering events that promote subsequent immune activation. There are several direct links between genetics and autoimmune disease in this pathway: the developmental maturation of T-cells in a genetically susceptible individual occurs through molecular interactions between the T-cell receptor and the HLA-peptide complex. Selection of T-cells with receptors likely to contribute to autoreactivity may preferentially occur in the context of specific HLA-DQ alleles that are diabetes prone, because of inefficiencies in the peptide-MHC structural interactions of these molecules. Subsequent activation of these T-cells in the context of recognizing islet-associated antigens can trigger a poorly regulated immune response that results in progressive islet destruction. These subsequent diabetes-specific events are also directed by specific HLA genes, most prominently by the binding of specific antigenic peptides by the disease-associated HLA molecules. In this sequential cascade, opportunities for environmental influences and modulation by non-HLA genes are identified that likely act in concert with the predominant genetic susceptibility contributed by the HLA molecules themselves. Clarification of the steps in this pathway extends our understanding of the prevailing role of HLA genes in IDDM pathogenesis and suggests opportunities to intervene at discrete initiating, disease-promoting, or regulatory steps in IDDM development.

  19. Planck intermediate results XXXVIII. E- and B-modes of dust polarization from the magnetized filamentary structure of the interstellar medium

    DEFF Research Database (Denmark)

    Ade, P. A. R.; Aghanim, N.; Arnaud, M.

    2016-01-01

    The quest for a B-mode imprint from primordial gravity waves on the polarization of the cosmic microwave background (CMB) requires the characterization of foreground polarization from Galactic dust. We present a statistical study of the filamentary structure of the 353 GHz Planck Stokes maps at h...

  20. PREVALENCE OF CELIAC DISEASE PREDISPOSING GENOTYPES, INCLUDING HLA-DQ2.2 VARIANT, IN BRAZILIAN CHILDREN.

    Science.gov (United States)

    Selleski, Nicole; Almeida, Lucas Malta; Almeida, Fernanda Coutinho de; Pratesi, Claudia Beatriz; Nóbrega, Yanna Karla de Medeiros; Gandolfi, Lenora

    2018-01-01

    Celiac disease is an autoimmune enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. Almost all celiac patients carry immune recognition genes coding for HLA-DQ2.5 and DQ8 heterodimers. Over the last few years, great importance has been given to HLA-DQ2.2 as probable predisposing variant, although controversies still exist regarding its relevance. The aim of our study was to determine the possible existence of an association between HLA-DQ2.2 and celiac disease in Brazilian children by analyzing the prevalence of the predisposing variants for celiac disease in a representative group of children of a population in which this determination is still missing. HLA-DQ typing was performed in samples from a group of celiac (n=100) and non-celiac children (n=110). All samples were tested for the presence of the following variants: DQA1*05-DQB1*02 (DQ2.5), DQA1*03-DQB1*03:02 (DQ8) and DQA1*02:01-DQB1*02:02 (DQ2.2). Fisher`s exact test was used for statistical analysis. In the group of 100 celiac children, 78 (78%) were positive for DQ2, 13 (13 %) were DQ2/DQ8 and 6 (6%) were DQ8 positives. The HLA-DQ pattern in the 110 non-celiac children was as follows: positive for DQ2 in 33 (29.9%) samples, in 2 (1.8 %) was positive for DQ2/DQ8 and in 15 (13.6%) was positive for DQ8. We found significant differences between the distribution of some but not all of the analyzed alleles when comparing celiac and non-celiac children. The genotyping of celiac disease HLA-DQ predisposing alleles showed similarities with HLA-DQ patterns found in both European and non-European populations, which may be a reflection of the miscegenation, which gave origin to the current Brazilian population. No significant association was found between DQ2.2 variant and celiac disease in the studied population.

  1. PREVALENCE OF CELIAC DISEASE PREDISPOSING GENOTYPES, INCLUDING HLA-DQ2.2 VARIANT, IN BRAZILIAN CHILDREN

    Directory of Open Access Journals (Sweden)

    Nicole SELLESKI

    Full Text Available ABSTRACT BACKGROUND: Celiac disease is an autoimmune enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. Almost all celiac patients carry immune recognition genes coding for HLA-DQ2.5 and DQ8 heterodimers. Over the last few years, great importance has been given to HLA-DQ2.2 as probable predisposing variant, although controversies still exist regarding its relevance. OBJECTIVE: The aim of our study was to determine the possible existence of an association between HLA-DQ2.2 and celiac disease in Brazilian children by analyzing the prevalence of the predisposing variants for celiac disease in a representative group of children of a population in which this determination is still missing. METHODS: HLA-DQ typing was performed in samples from a group of celiac (n=100 and non-celiac children (n=110. All samples were tested for the presence of the following variants: DQA1*05-DQB1*02 (DQ2.5, DQA1*03-DQB1*03:02 (DQ8 and DQA1*02:01-DQB1*02:02 (DQ2.2. Fisher`s exact test was used for statistical analysis. RESULTS: In the group of 100 celiac children, 78 (78% were positive for DQ2, 13 (13 % were DQ2/DQ8 and 6 (6% were DQ8 positives. The HLA-DQ pattern in the 110 non-celiac children was as follows: positive for DQ2 in 33 (29.9% samples, in 2 (1.8 % was positive for DQ2/DQ8 and in 15 (13.6% was positive for DQ8. We found significant differences between the distribution of some but not all of the analyzed alleles when comparing celiac and non-celiac children. CONCLUSION: The genotyping of celiac disease HLA-DQ predisposing alleles showed similarities with HLA-DQ patterns found in both European and non-European populations, which may be a reflection of the miscegenation, which gave origin to the current Brazilian population. No significant association was found between DQ2.2 variant and celiac disease in the studied population.

  2. Online Tools for Uncovering Data Quality (DQ) Issues in Satellite-Based Global Precipitation Products

    Science.gov (United States)

    Liu, Zhong; Heo, Gil

    2015-01-01

    Data quality (DQ) has many attributes or facets (i.e., errors, biases, systematic differences, uncertainties, benchmark, false trends, false alarm ratio, etc.)Sources can be complicated (measurements, environmental conditions, surface types, algorithms, etc.) and difficult to be identified especially for multi-sensor and multi-satellite products with bias correction (TMPA, IMERG, etc.) How to obtain DQ info fast and easily, especially quantified info in ROI Existing parameters (random error), literature, DIY, etc.How to apply the knowledge in research and applications.Here, we focus on online systems for integration of products and parameters, visualization and analysis as well as investigation and extraction of DQ information.

  3. INTERFEROMETRIC EVIDENCE FOR RESOLVED WARM DUST IN THE DQ TAU SYSTEM

    International Nuclear Information System (INIS)

    Boden, Andrew F.; Sargent, Anneila I.; Carpenter, John M.; Akeson, Rachel L.; Ciardi, David R.; Bary, Jeffrey S.; Skrutskie, Michael F.

    2009-01-01

    We report on near-infrared (IR) interferometric observations of the double-lined pre-main sequence binary system DQ Tau. We model these data with a visual orbit for DQ Tau supported by the spectroscopic orbit and analysis of Mathieu et al. Further, DQ Tau exhibits significant near-IR excess; modeling our data requires inclusion of near-IR light from an 'excess' source. Remarkably, the excess source is resolved in our data, similar in scale to the binary itself (∼0.2 AU at apastron), rather than the larger circumbinary disk (∼0.4 AU radius). Our observations support the Mathieu et al. and Carr et al. inference of significant warm material near the DQ Tau binary.

  4. Absolute linkage of celiac disease and dermatitis herpetiformis to HLA-DQ.

    Science.gov (United States)

    Balas, A; Vicario, J L; Zambrano, A; Acuña, D; García-Novo, D

    1997-07-01

    This report shows the absolute genetic linkage of celiac disease (CD) to the HLA-DQ region, and supports the fact that dermatitis herpetiformis (DH) follows the same pattern of HLA-mediated susceptibility in extensive series of Caucasian Spanish patients. Ninety-five percent of CD (201 of 212) and 100% of DH (55) patients could produce DQ alpha 1*0501-DQ beta 1*02 heterodimers. Negative CD patients for this combination were mostly DR4-DQ8 (DQA1*03-DQB1*0302) (9 OF 11), along with a restricted number of complementary chromosomes. Comparison of observed and expected DQA1-DQB1 genotype distributions (Hardy-Weinberg equilibrium) showed that the excess of patients with DQB1*02 in double doses would be the consequence for which this allele should be complemented by DQA1*0501. Homozygosity for DQA1*0501 would restrain susceptibility to CD and DH.

  5. DNA locus HLA-DQ alpha polymorphism in human population of the north-eastern Poland.

    Science.gov (United States)

    Pepiński, W; Skawrońska, M; Janica, J

    1996-01-01

    Investigations on DNA polymorphism locus HLA-DQ alpha were carried out on a sample of 117 adult unrelated inhabitants from the north-eastern Poland. The polymerase chain reaction and the reverse dot-blot hybridisation were employed to detect 6 different HLA-DQ alpha alleles. Population data on 20 different genotypes served as a basis for statistic evaluation. The results of genotype analysis were in Hardy-Weinberg equilibrium. Other population data were compared.

  6. Deletion mutant defines DQ beta variants with DR4 positive DQw3 positive haplotypes

    International Nuclear Information System (INIS)

    Nepom, B.S.; Kim, S.J.; Nepom, G.T.

    1986-01-01

    We describe the production of an HLA deletion mutation by radiation mutagenesis of a DR4- and DQw3-homozygous, Dw4- and Dw14-heterozygous cell line designed to analyze polymorphisms associated with DR4 and DQw3. Southern blot analysis confirms a deletion of class I and class II genes on one haplotype. Variation in DQ beta alleles associated with DQw3 was previously described by characteristic RFLP patterns for a DQ beta bene. One pattern, which correlated precisely with A-10-83 monoclonal antibody reactivity (TA10), defined an allele which we call DQ''3.1''. The mutant cell line has lost the polymorphic bands on Southern blots corresponding to the DQ''3.1'' allele, while the intact Dw14 haplotype retains the alternate allele at DQ beta which is DQw-3 positive. TA10-negative. These data demonstrate the segregation of two DQw3 positive DQ beta allelic variants, both associated with DR4, which can be distinguished on the basis of both RFLP and monoclonal antibody reactivity

  7. Planck intermediate results L. Evidence of spatial variation of the polarized thermal dust spectral energy distribution and implications for CMB B-mode analysis

    DEFF Research Database (Denmark)

    Aghanim, N.; Ashdown, M.; Aumont, J.

    2017-01-01

    that the decorrelation increases when there is a decrease in the mean column density of the region of the sky being considered, and we propose a simple power-law empirical model for this dependence, which matches what is seen in the Planck data. We explore the effect that this measured decorrelation has on simulations...... of the polarized thermal dust emission at high Galactic latitudes. Here, we specifically study the spatial variability of the dust polarized spectral energy distribution (SED), and its potential impact on the determination of the tensor-to-scalar ratio, r. We use the correlation ratio of the CBB `angular power...

  8. Planck intermediate results. L. Evidence of spatial variation of the polarized thermal dust spectral energy distribution and implications for CMB B-mode analysis

    Science.gov (United States)

    Planck Collaboration; Aghanim, N.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Ballardini, M.; Banday, A. J.; Barreiro, R. B.; Bartolo, N.; Basak, S.; Benabed, K.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Boulanger, F.; Bracco, A.; Burigana, C.; Calabrese, E.; Cardoso, J.-F.; Chiang, H. C.; Colombo, L. P. L.; Combet, C.; Comis, B.; Crill, B. P.; Curto, A.; Cuttaia, F.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Delouis, J.-M.; Di Valentino, E.; Dickinson, C.; Diego, J. M.; Doré, O.; Douspis, M.; Ducout, A.; Dupac, X.; Dusini, S.; Efstathiou, G.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Falgarone, E.; Fantaye, Y.; Finelli, F.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Frolov, A.; Galeotta, S.; Galli, S.; Ganga, K.; Génova-Santos, R. T.; Gerbino, M.; Ghosh, T.; Giard, M.; González-Nuevo, J.; Górski, K. M.; Gregorio, A.; Gruppuso, A.; Gudmundsson, J. E.; Hansen, F. K.; Helou, G.; Herranz, D.; Hivon, E.; Huang, Z.; Jaffe, A. H.; Jones, W. C.; Keihänen, E.; Keskitalo, R.; Kisner, T. S.; Krachmalnicoff, N.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Le Jeune, M.; Levrier, F.; Liguori, M.; Lilje, P. B.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; Maggio, G.; Maino, D.; Mandolesi, N.; Mangilli, A.; Maris, M.; Martin, P. G.; Martínez-González, E.; Matarrese, S.; Mauri, N.; McEwen, J. D.; Melchiorri, A.; Mennella, A.; Migliaccio, M.; Mitra, S.; Miville-Deschênes, M.-A.; Molinari, D.; Moneti, A.; Montier, L.; Morgante, G.; Moss, A.; Naselsky, P.; Nørgaard-Nielsen, H. U.; Oxborrow, C. A.; Pagano, L.; Paoletti, D.; Partridge, B.; Patrizii, L.; Perdereau, O.; Perotto, L.; Pettorino, V.; Piacentini, F.; Plaszczynski, S.; Polenta, G.; Puget, J.-L.; Rachen, J. P.; Reinecke, M.; Remazeilles, M.; Renzi, A.; Rocha, G.; Rossetti, M.; Roudier, G.; Rubiño-Martín, J. A.; Ruiz-Granados, B.; Salvati, L.; Sandri, M.; Savelainen, M.; Scott, D.; Sirignano, C.; Sirri, G.; Stanco, L.; Suur-Uski, A.-S.; Tauber, J. A.; Tenti, M.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Trombetti, T.; Valiviita, J.; Vansyngel, F.; Van Tent, F.; Vielva, P.; Wandelt, B. D.; Wehus, I. K.; Zacchei, A.; Zonca, A.

    2017-03-01

    The characterization of the Galactic foregrounds has been shown to be the main obstacle in thechallenging quest to detect primordial B-modes in the polarized microwave sky. We make use of the Planck-HFI 2015 data release at high frequencies to place new constraints on the properties of the polarized thermal dust emission at high Galactic latitudes. Here, we specifically study the spatial variability of the dust polarized spectral energy distribution (SED), and its potential impact on the determination of the tensor-to-scalar ratio, r. We use the correlation ratio of the angular power spectra between the 217 and 353 GHz channels as a tracer of these potential variations, computed on different high Galactic latitude regions, ranging from 80% to 20% of the sky. The new insight from Planck data is a departure of the correlation ratio from unity that cannot be attributed to a spurious decorrelation due to the cosmic microwave background, instrumental noise, or instrumental systematics. The effect is marginally detected on each region, but the statistical combination of all the regions gives more than 99% confidence for this variation in polarized dust properties. In addition, we show that the decorrelation increases when there is a decrease in the mean column density of the region of the sky being considered, and we propose a simple power-law empirical model for this dependence, which matches what is seen in the Planck data. We explore the effect that this measured decorrelation has on simulations of the BICEP2-Keck Array/Planck analysis and show that the 2015 constraints from these data still allow a decorrelation between the dust at 150 and 353 GHz that is compatible with our measured value. Finally, using simplified models, we show that either spatial variation of the dust SED or of the dust polarization angle are able to produce decorrelations between 217 and 353 GHz data similar to the values we observe in the data.

  9. SIMPLIFYING CELIAC DISEASE PREDISPOSING HLA-DQ ALLELES DETERMINATION BY THE REAL TIME PCR METHOD

    Directory of Open Access Journals (Sweden)

    Nicole SELLESKI

    2015-06-01

    Full Text Available Background Celiac disease is an autoimmune enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. Genetic susceptibility is associated with two sets of alleles, DQA1*05 - DQB1*02 and DQA1*03 - DQB1*03:02, which code for class II MHC DQ2 and DQ8 molecules, respectively. Approximately 90%-95% of celiac patients are HLA-DQ2 positive, and half of the remaining patients are HLA-DQ8 positive. In fact, during a celiac disease diagnostic workup, the absence of these specific DQA and DQB alleles has a near perfect negative predictive value. Objective Improve the detection of celiac disease predisposing alleles by combining the simplicity and sensitivity of real-time PCR (qPCR and melting curve analysis with the specificity of sequence-specific primers (SSP. Methods Amplifications of sequence-specific primers for DQA1*05 (DQ2, DQB1*02 (DQ2, and DQA1*03 (DQ8 were performed by the real time PCR method to determine the presence of each allele in independent reactions. Primers for Human Growth Hormone were used as an internal control. A parallel PCR-SSP protocol was used as a reference method to validate our results. Results Both techniques yielded equal results. From a total of 329 samples the presence of HLA predisposing alleles was determined in 187 (56.8%. One hundred fourteen samples (61% were positive for a single allele, 68 (36.3% for two alleles, and only 5 (2.7% for three alleles. Conclusion Results obtained by qPCR technique were highly reliable with no discordant results when compared with those obtained using PCR-SSP.

  10. Mutational analysis of the HLA-DQ3.2 insulin-dependent diabetes mellitus susceptibility gene

    International Nuclear Information System (INIS)

    Kwok, W.W.; Lotshaw, C.; Milner, E.C.B.; Knitter-Jack, N.; Nepom, G.T.

    1989-01-01

    The human major histocompatibility complex includes approximately 14 class II HLA genes within the HLA-D region, most of which exist in multiple allelic forms. One of these genes, the DQ3.2β gene, accounts for the well-documented association of HLA-DR4 with insulin-dependent diabetes mellitus and is the single allele most highly correlated with this disease. The authors analyzed the amino acid substitutions that lead to the structural differences distinguishing DQ3.2β from its nondiabetogenic, but closely related allele, DQ3.1β. Site-directed mutagenesis of the DQ3.2β gene was used to convert key nucleotides into DQ3.2β codons. Subsequent expression studies of these mutated DQ3.2β clones using retroviral vectors defined amino acid 45 as critical for generating serologic epitopes characterizing the DQw3.1β and DQw3.2β molecules

  11. Ancient roots for polymorphism at the HLA-DQ. alpha. locus in primates

    Energy Technology Data Exchange (ETDEWEB)

    Gyllensten, U.B.; Erlich, H.A. (Cetus Corp., Emeryville, CA (USA))

    1989-12-01

    The genes encoding the human histocompatibility antigens (HLA) exhibit a remarkable degree of polymorphism as revealed by immunologic and molecular analyses. This extensive sequence polymorphism either may have been generated during the lifetime of the human species or could have arisen before speciation and been maintained in the contemporary human population by selection or, possibly, by genetic drift. These two hypotheses were examined using the polymerase chain reaction method to amplify polymorphic sequences from the DQ{alpha} locus, as well as the DX{alpha} locus, an homologous but nonexpressed locus, in a series of primates that diverged at known times. In general, the amino acid sequence of a specific human DQ{alpha} allelic type is more closely related to its chimpanzee or gorilla counterpart than to other human DQ{alpha} alleles. Phylogenetic analysis of the silent nucleotide position changes shows that the similarity of allelic types between species is due to common ancestry rather than convergent evolution. Thus, most of the polymorphism at the DQ{alpha} locus in the human species was already present at least 5 million years ago in the ancestral species that gave rise to the chimpanzee, gorilla, and human lineages. However, one of the DQ{alpha} alleles may have arisen after speciation by recombination between two ancestral alleles.

  12. Relevance of HLA-DP/DQ and ICAM-1 SNPs among Ovarian Cancer Patients.

    Science.gov (United States)

    Ghazy, Amany A; El-Etreby, Nour M

    2016-01-01

    Ovarian cancer is one of the most lethal gynecological malignancies and the fifth leading cause of cancer deaths among women. The high mortality rate is largely attributed to its diagnosis in advanced stages. Poor prognosis of ovarian cancer is usually due to the lack of specific or effective screening and diagnostic methods for identifying early-stage disease. Our study aimed to study the role of HLA-DP, HLA-DQ, and ICAM-1 SNPs in diagnosis and/or prognosis of ovarian tumors. The current study was conducted on 60 patients with ovarian tumors (benign, borderline, and malignant) and 20 healthy volunteers. Genotyping of HLA-DP rs3077, HLA-DQ rs3920, and ICAM-1 rs1437 SNPs was done using 5' nuclease assay. We found significant association of HLA-DP rs3077 AA, HLA-DQ rs3920 GG, ICAM-1 rs1437 CC, and CT genotypes with increased risk of ovarian cancer (OR = 43.5, 6, 25, and 2.6, respectively). In addition, HLA-DQ rs3920 and ICAM-1 rs1437 alleles vary significantly among different types of ovarian cancer (P = 0.003 and 0.001, respectively). HLA-DP rs3077, HLA-DQ rs3920, and ICAM-1 rs1437 SNPs could help in the diagnosis and prognosis of ovarian cancer.

  13. High Frequency of Haplotype HLA-DQ7 in Celiac Disease Patients from South Italy: Retrospective Evaluation of 5,535 Subjects at Risk of Celiac Disease.

    Directory of Open Access Journals (Sweden)

    Nadia Tinto

    Full Text Available Celiac disease (CD has a strong genetic component mainly due to HLA DQ2/DQ8 encoding genes. However, a minority of CD patients are DQ2/DQ8-negative. To address this issue, we retrospectively characterized HLA haplotypes in 5,535 subjects at risk of CD (either relatives of CD patients or subjects with CD-like symptoms referred to our center during a 10-year period.We identified loci DQA1/DQB1/DRB1 by sequence-specific oligonucleotide-PCR and sequence-specific primer-PCR; anti-transglutaminase IgA/IgG and anti-endomysium IgA by ELISA and indirect immunofluorescence, respectively.We diagnosed CD in 666/5,535 individuals, 4.2% of whom were DQ2/DQ8-negative. Interestingly, DQ7 was one of the most abundant haplotypes in all CD patients and significantly more frequent in DQ2/DQ8-negative (38% than in DQ2/DQ8-positive CD patients (24% (p<0.05.Our data lend support to the concept that DQ7 represents an additive or independent CD risk haplotype with respect to DQ2/DQ8 haplotypes but this finding should be verified in other large CD populations.

  14. Dynamic Modeling of Networks, Microgrids, and Renewable Sources in the dq0 Reference Frame

    DEFF Research Database (Denmark)

    Baimel, Dmitry; Belikov, Juri; Guerrero, Josep M.

    2017-01-01

    to simplify the analysis of dynamic phenomena, among them are models based on the dq0 transformation. Many recent works present dq0-based models of various power system components, ranging from small renewable sources to complete networks. The purpose of this paper is to review and categorize these works......With increasing the penetration of distributed and renewable sources into power grids, and with increasing the use of power electronics-based devices, the dynamic behavior of large-scale power systems is becoming increasingly complex. These recent developments have led to several models attempting...

  15. Relationship between HLA-DQ Gene Polymorphism and Hepatitis B Virus Infection

    Directory of Open Access Journals (Sweden)

    Tao Xu

    2017-01-01

    Full Text Available Hepatitis B virus (HBV infection is the predominant risk factor for chronic hepatitis B (CHB. The association between HBV infection and human leukocyte antigen- (HLA- DQ polymorphism (rs2856718 and rs7453920 has been demonstrated in other studies; however, the results were controversial or inconclusive. Therefore, to derive a more precise estimation of the association, a meta-analysis was performed. Crude odds ratios (ORs and their 95% confidence intervals (CIs were used to assess the strength of association between HLA-DQ polymorphism (rs2856718 and rs7453920 and HBV infection risk. A total of 11 articles were used to evaluate the effect of the two polymorphisms on risk of HBV infection. The pooled data showed that HLA-DQ rs2856718-G polymorphism showed protection against HBV infection, and rs2856718-A was a risk factor for chronic HBV infection. The pooled risk estimates indicated that HLA-DQ rs7453920-A polymorphism was associated with decreased risk of HBV infection, and rs7453920-G serves as a risk factor in HBV infection. However, these stratified analyses were lacking credibility due to the limitation of correlational study numbers; further investigation on a large population and different ethnicities is warranted.

  16. Gradiente de riesgo genético HLA-DQ para diabetes tipo 1 y enfermedad celíaca en el noroeste de México

    Directory of Open Access Journals (Sweden)

    M.E. Mejía-León

    2015-04-01

    Conclusión: Los sonorenses tienen una distribución de alelos HLA-DQ distintiva debido a su ascendencia. Las combinaciones del HLA-DQ8 con DQ2 o uno de sus alelos confirieron el máximo riesgo para ambas enfermedades. La DT1 y EC frecuentemente se presentan juntas.

  17. Crystal fields of porphyrins and phthalocyanines from polarization-dependent 2p-to-3d multiplets

    DEFF Research Database (Denmark)

    Johnson, Phillip S.; García Lastra, Juan Maria; Kennedy, Colton K.

    2014-01-01

    Polarization-dependent X-ray absorption spectroscopy is combined with density functional calculations and atomic multiplet calculations to determine the crystal field parameters 10Dq, Ds, and Dt of transition metal phthalocyanines and octaethylporphyrins (Mn, Fe, Co, Ni). The polarization depende...

  18. A new HLA-DQA1 RFLP allele (DQ. alpha. 3b) distinguishes between DQ. alpha. genes of DQw2-DR3 and DQw3-DR5 haplotypes

    Energy Technology Data Exchange (ETDEWEB)

    Martinez-Laso, J.; Vicario, J.L.; Corell, A.; Morales, P.; Regueiro, J.R.; Arnaiz-Villena, A. (Immunologia Hospital, Madrid (Spain))

    1989-06-26

    A 797 bp Pst I fragment, DQA1 pDHC1 was used as a probe. Genomic DNA Taq I (T CGA) digests hybridized with the DQA1 probe show two distinct RFLP alleles where it was thought only to be one, i.e.: 4.9 kb and a 4.8 kb band instead of the previously described 4.8 kb fragment (named DQ{alpha}2,2). The allele frequency was analyzed in 214 individuals. The DQA1 gene is localized in the HLA region on the short arm of human chromosome 6. Separate co-dominant segregation of the 4.8 and 4.9 alleles was assessed in 3 families with 16 individuals. The results show that the previously described 4.8 kb DQA1-Taq I band (named DQ{alpha}2,2) which was found associated with DRw11, 12, 13b, 17.1 and 17.2 may be really split in two different alleles; they are overlapping and not distinguishable in short-run gels.

  19. High-Speed Current dq PI Controller for Vector Controlled PMSM Drive

    Science.gov (United States)

    Reaz, Mamun Bin Ibne; Rahman, Labonnah Farzana; Chang, Tae Gyu

    2014-01-01

    High-speed current controller for vector controlled permanent magnet synchronous motor (PMSM) is presented. The controller is developed based on modular design for faster calculation and uses fixed-point proportional-integral (PI) method for improved accuracy. Current dq controller is usually implemented in digital signal processor (DSP) based computer. However, DSP based solutions are reaching their physical limits, which are few microseconds. Besides, digital solutions suffer from high implementation cost. In this research, the overall controller is realizing in field programmable gate array (FPGA). FPGA implementation of the overall controlling algorithm will certainly trim down the execution time significantly to guarantee the steadiness of the motor. Agilent 16821A Logic Analyzer is employed to validate the result of the implemented design in FPGA. Experimental results indicate that the proposed current dq PI controller needs only 50 ns of execution time in 40 MHz clock, which is the lowest computational cycle for the era. PMID:24574913

  20. DQ reference frame modeling and control of single-phase active power decoupling circuits

    DEFF Research Database (Denmark)

    Tang, Yi; Qin, Zian; Blaabjerg, Frede

    2015-01-01

    Power decoupling circuits can compensate the inherent double line frequency ripple power in single-phase systems and greatly facilitate their dc-link capacitor design. Example applications of power decoupling circuit include photovoltaic, light-emitting diode, fuel cell, and motor drive systems....... This paper presents the dq synchronous reference frame modeling of single-phase power decoupling circuits and a complete model describing the dynamics of dc-link ripple voltage is presented. The proposed model is universal and valid for both inductive and capacitive decoupling circuits, and the input...... of decoupling circuits can be either dependent or independent of its front-end converters. Based on this model, a dq synchronous reference frame controller is designed which allows the decoupling circuit to operate in two different modes because of the circuit symmetry. Simulation and experimental results...

  1. Questionable expression of unstable DQ heterodimer containing HLA-DQA1*01 : 07

    NARCIS (Netherlands)

    Miyadera, H.; Bungener, L. B.; Kusano, S.; Yokoyama, S.; Tokunaga, K.; Hepkema, B. G.

    2015-01-01

    Human leukocyte antigens (HLA)-DQA1*01:07 was identified as an HLA-DQ blank specificity that segregated with the serological HLA-A2, -B7, -DR14, -DR52 haplotype, which carried DQB1*05:03. The blank specificity of DQA1*01:07-DQB1*05:03 may be because of lack of reactivity of available typing sera, or

  2. MHC2NNZ: A novel peptide binding prediction approach for HLA DQ molecules

    Science.gov (United States)

    Xie, Jiang; Zeng, Xu; Lu, Dongfang; Liu, Zhixiang; Wang, Jiao

    2017-07-01

    The major histocompatibility complex class II (MHC-II) molecule plays a crucial role in immunology. Computational prediction of MHC-II binding peptides can help researchers understand the mechanism of immune systems and design vaccines. Most of the prediction algorithms for MHC-II to date have made large efforts in human leukocyte antigen (HLA, the name of MHC in Human) molecules encoded in the DR locus. However, HLA DQ molecules are equally important and have only been made less progress because it is more difficult to handle them experimentally. In this study, we propose an artificial neural network-based approach called MHC2NNZ to predict peptides binding to HLA DQ molecules. Unlike previous artificial neural network-based methods, MHC2NNZ not only considers sequence similarity features but also captures the chemical and physical properties, and a novel method incorporating these properties is proposed to represent peptide flanking regions (PFR). Furthermore, MHC2NNZ improves the prediction accuracy by combining with amino acid preference at more specific positions of the peptides binding core. By evaluating on 3549 peptides binding to six most frequent HLA DQ molecules, MHC2NNZ is demonstrated to outperform other state-of-the-art MHC-II prediction methods.

  3. Importance of surface characteristics of QUARTZ DQ 12 for acute inflammation

    Energy Technology Data Exchange (ETDEWEB)

    Albrecht, C.; Becher, A.; Scins, R.P.F.; Hoehr, D.; Unfried, K.; Knaapen, A.M.; Borm, P.J.A. [Institut fuer medizinische Forschung (IUF), Duesseldorf (Germany)

    2004-07-01

    Although quartz is known to induce inflammation in rat lungs, mechanisms are not yet fully understood. The importance of particle surface characteristics was investigated in vivo after intratracheal instillation of different preparations of quartz in rat lungs. Three days after instillation of 2 mg DQ12 quartz, or DQ12 coated with polyvinylpyridine-N-oxide (PVNO) or Aluminium lactate (AL), lungs of female Wistar rats were lavaged in situ to determine markers of inflammation. Control rats received saline or the coating substances alone. DQ12 induced a marked inflammatory response, as indicated by a significant increase in the number of neutrophils and macrophages, as well as in the levels of b-glucuronidase and myeloperoxidase. None of these inflammatory markers was increased for both coated quartz preparations, with the exception of neutrophil influx which was also increased after treatment with AL quartz. Our results indicate that surface characteristics are important in the onset of quartz-induced lung inflammation which could imply a different development of persistent inflammation. This will be investigated in later follow-up time points of the same animal study. (orig.)

  4. Polymorphism at expressed DQ and DR loci in five common equine MHC haplotypes.

    Science.gov (United States)

    Miller, Donald; Tallmadge, Rebecca L; Binns, Matthew; Zhu, Baoli; Mohamoud, Yasmin Ali; Ahmed, Ayeda; Brooks, Samantha A; Antczak, Douglas F

    2017-03-01

    The polymorphism of major histocompatibility complex (MHC) class II DQ and DR genes in five common equine leukocyte antigen (ELA) haplotypes was determined through sequencing of mRNA transcripts isolated from lymphocytes of eight ELA homozygous horses. Ten expressed MHC class II genes were detected in horses of the ELA-A3 haplotype carried by the donor horses of the equine bacterial artificial chromosome (BAC) library and the reference genome sequence: four DR genes and six DQ genes. The other four ELA haplotypes contained at least eight expressed polymorphic MHC class II loci. Next generation sequencing (NGS) of genomic DNA of these four MHC haplotypes revealed stop codons in the DQA3 gene in the ELA-A2, ELA-A5, and ELA-A9 haplotypes. Few NGS reads were obtained for the other MHC class II genes that were not amplified in these horses. The amino acid sequences across haplotypes contained locus-specific residues, and the locus clusters produced by phylogenetic analysis were well supported. The MHC class II alleles within the five tested haplotypes were largely non-overlapping between haplotypes. The complement of equine MHC class II DQ and DR genes appears to be well conserved between haplotypes, in contrast to the recently described variation in class I gene loci between equine MHC haplotypes. The identification of allelic series of equine MHC class II loci will aid comparative studies of mammalian MHC conservation and evolution and may also help to interpret associations between the equine MHC class II region and diseases of the horse.

  5. Questionable expression of unstable DQ heterodimer containing HLA-DQA1*01:07.

    Science.gov (United States)

    Miyadera, H; Bungener, L B; Kusano, S; Yokoyama, S; Tokunaga, K; Hepkema, B G

    2015-12-01

    Human leukocyte antigens (HLA)-DQA1*01:07 was identified as an HLA-DQ blank specificity that segregated with the serological HLA-A2, -B7, -DR14, -DR52 haplotype, which carried DQB1*05:03. The blank specificity of DQA1*01:07-DQB1*05:03 may be because of lack of reactivity of available typing sera, or disruption of proper assembly of DQ heterodimer. The cDNA sequence of DQA1*01:07 is nearly identical to DQA1*01:04 except for a variant at position 304, which results in the replacement of an arginine with a cysteine at 79α. To determine whether the DQA1*01:07 product can be expressed on cell-surface, we co-expressed DQA1*01:07 with various DQB1*05 or *06 alleles in fibroblast cells. Cell-surface expression of DQ was detectable when DQA1*01:07 was co-expressed with DQB1*06:04 but undetectable with other DQB1*05 and DQB1*06 alleles, including DQB1*05:03, to which DQA1*01:07 was encoded in cis. These data suggest that DQA1*01:07 may act as a phenotypically null allele in the DQA1*01:07-DQB1*05:03 haplotype, while it can be expressed at a low level in the presences of certain DQB1*06 alleles, such as DQB1*06:04, in trans. Based on the null or low expression of DQA1*01:07 as shown in the previous and present studies, DQA1*01:07 has recently been renamed to DQA1*01:07Q, indicating its questionable expression. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  6. Polymorphism at Expressed DQ and DR Loci in Five Common Equine MHC Haplotypes

    Science.gov (United States)

    Miller, Donald; Tallmadge, Rebecca L.; Binns, Matthew; Zhu, Baoli; Mohamoud, Yasmin Ali; Ahmed, Ayeda; Brooks, Samantha A.; Antczak, Douglas F.

    2016-01-01

    The polymorphism of Major Histocompatibility Complex (MHC) class II DQ and DR genes in five common Equine Leukocyte Antigen (ELA) haplotypes was determined through sequencing of mRNA transcripts isolated from lymphocytes of eight ELA homozygous horses. Ten expressed MHC class II genes were detected in horses of the ELA-A3 haplotype carried by the donor horses of the equine Bacterial Artificial Chromosome (BAC) library and the reference genome sequence: four DR genes and six DQ genes. The other four ELA haplotypes contained at least eight expressed polymorphic MHC class II loci. Next Generation Sequencing (NGS) of genomic DNA of these four MHC haplotypes revealed stop codons in the DQA3 gene in the ELA-A2, ELA-A5, and ELA-A9 haplotypes. Few NGS reads were obtained for the other MHC class II genes that were not amplified in these horses. The amino acid sequences across haplotypes contained locus-specific residues, and the locus clusters produced by phylogenetic analysis were well supported. The MHC class II alleles within the five tested haplotypes were largely non-overlapping between haplotypes. The complement of equine MHC class II DQ and DR genes appears to be well conserved between haplotypes, in contrast to the recently described variation in class I gene loci between equine MHC haplotypes. The identification of allelic series of equine MHC class II loci will aid comparative studies of mammalian MHC conservation and evolution and may also help to interpret associations between the equine MHC class II region and diseases of the horse. PMID:27889800

  7. VizieR Online Data Catalog: UBVR photometry of the T Tauri binary DQ Tau (Tofflemire+, 2017)

    Science.gov (United States)

    Tofflemire, B. M.; Mathieu, R. D.; Ardila, D. R.; Akeson, R. L.; Ciardi, D. R.; Johns-Krull, C.; Herczeg, G. J.; Quijano-Vodniza, A.

    2017-08-01

    The Las Cumbres Observatories Global Telescope (LCOGT) 1m network consists of nine 1m telescopes spread across four international sites: McDonald Observatory (USA), CTIO (Chile), SAAO (South Africa), and Siding Springs Observatory (Australia). Over the 2014-2015 winter observing season, our program requested queued "visits" of DQ Tau 20 times per orbital cycle for 10 continuous orbital periods. Given the orbital period of DQ Tau, the visit cadence corresponded to ~20hr. Each visit consisted of three observations in each of the broadband UBVRIY and narrowband Hα and Hβ filters, requiring ~20 minutes. In this work we present only the UBVR observations, which overlap with our high-cadence observations. Indeed, two eight-night observing runs centered on separate periastron passages of DQ Tau (orbital cycles 3 and 5 in Figure 1) were obtained from the WIYN 0.9m telescope located at the Kitt Peak National Observatory. In addition to our two eight-night observing runs, a synoptic observation program was also in place at the WIYN 0.9m that provided approximately weekly observations of DQ Tau in UBVR during the 2014-B semester. Also, using Apache Point Observatory's ARCSAT 0.5m telescope, we performed observing runs of seven and ten nights centered on two separate periastron passaged of DQ Tau (orbital cycles 2 and 7 in Figure 1). (1 data file).

  8. Significant Association of HLA-DQ5 with Autoimmune Hepatitis in Taiwan

    Directory of Open Access Journals (Sweden)

    Lok-Beng Koay

    2007-12-01

    Full Text Available Genetic predisposition is known to be an important etiopathogenic factor of autoimmune hepatitis (AIH. HLA antigens associated with AIH have been well studied in Western countries and Japan, but there is no HLA typing data of AIH patients in Taiwan. We therefore investigated HLA phenotypes and their association with AIH patients and compared the results with those of normal subjects and patients with chronic liver disease. Group 1 consisted of 22 AIH patients. All were born in Taiwan with no history of blood transfusion. Group 2 consisted of 19 chronic liver disease patients. Group 3 consisted of 81 unrelated healthy subjects who were normal blood donors. All three groups were tested for HLA phenotypes (HLAA, B, C, DR, DQ using the polymerase chain reaction—sequence specific probe method. The statistical method used was Fisher's exact test. We found that HLA-DQ5 was significantly more frequent in the AIH group compared to the control group (RR, 2.03; p = 0.034. Low frequency of A1 (n = 2/22, B8 (n = 1/22 and DR3 (n = 0/22 were noted compared to results from the West; only HLA-DR4 showed a higher rate in our AIH patients (n = 8/22. This is a preliminary report of our study of HLA antigens in AIH patients. Further investigation to characterize AIH patients into HLA allelic subgroups is being done.

  9. Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma

    Directory of Open Access Journals (Sweden)

    Jingzhu Lv

    2017-01-01

    Full Text Available Hepatocellular carcinoma (HCC is one of the most common causes of cancer-related mortality worldwide. Host gene variants may influence hepatitis B virus- (HBV- related HCC. Human leukocyte antigens (HLA play an important role in presenting virus antigens to immune cells that are responsible for the clearance of virus-infected cells and tumor cells. Previous studies have investigated the HLA-DQ (rs2856718 and rs9275572 polymorphisms that may be associated with the development of HBV-related HCC. However, the results are controversial or inconclusive. Hence, we conducted a meta-analysis to derive a more precise estimation of the associations. A total of 6 articles were used to evaluate the effect of the two polymorphisms on the risk of HBV-related HCC. Odds ratios (ORs and 95% confidence intervals (95% CIs were calculated. We found that rs2856718 and rs9275572 in HLA-DQ significantly decreased HBV-related HCC in total population, especially in Chinese, but not in Saudi Arabian. Further validation of our results in larger populations and different ethnicities are required.

  10. Association between HLA-DQ Gene Polymorphisms and HBV-Related Hepatocellular Carcinoma.

    Science.gov (United States)

    Lv, Jingzhu; Xu, Tao; Qian, Zhongqing; Wang, Hongtao

    2017-01-01

    Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related mortality worldwide. Host gene variants may influence hepatitis B virus- (HBV-) related HCC. Human leukocyte antigens (HLA) play an important role in presenting virus antigens to immune cells that are responsible for the clearance of virus-infected cells and tumor cells. Previous studies have investigated the HLA-DQ (rs2856718 and rs9275572) polymorphisms that may be associated with the development of HBV-related HCC. However, the results are controversial or inconclusive. Hence, we conducted a meta-analysis to derive a more precise estimation of the associations. A total of 6 articles were used to evaluate the effect of the two polymorphisms on the risk of HBV-related HCC. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. We found that rs2856718 and rs9275572 in HLA-DQ significantly decreased HBV-related HCC in total population, especially in Chinese, but not in Saudi Arabian. Further validation of our results in larger populations and different ethnicities are required.

  11. Characterization of the fine specificity of peptide antibodies to HLA-DQ beta-chain molecules

    DEFF Research Database (Denmark)

    Petersen, J S; Atar, D; Karlsen, Alan E

    1990-01-01

    In an attempt to produce epitope specific antisera which could distinguish two closely associated HLA-DQ beta-chain alleles, we immunized 20 rabbits with synthetic peptides representing sequences from the first domain of the HLA-DQw8 and -DQw7 beta-chain molecules, differing only by one amino acid...... in position 57. Several of the antisera in immunoblotting specifically recognized either the HLA-DQw7 or the HLA-DQw8 beta-chain allele as previously reported. The fine specificity of the antisera was tested in ELISA using synthetic peptides of varying length as solid phase antigen. Two out of the 20 antisera...... specifically recognized DQw7 beta peptides and two antisera bound only to DQw8 beta peptides from the region containing the amino acid in position 57. To analyze whether the antisera bound to native HLA-DQ beta-chain molecules, FACS analysis was carried out. Seven of the 20 antisera bound to intact EBV...

  12. DQ thermal buckling analysis of embedded curved carbon nanotubes based on nonlocal elasticity theory

    Directory of Open Access Journals (Sweden)

    AliReza Setoodeh

    Full Text Available Abstract To investigate the thermal buckling of curved carbon nanotubes (CCNTs embedded in an elastic medium, nonlocal elasticity theory is employed in combination with the theory of thin curved beams. Differential quadrature (DQ method is implemented to discretize the resulted governing equations. Solving these equations enables us to estimate the critical temperature and the critical axial buckling load for CCNTs surrounded by an elastic medium and under the effect of a uniform temperature change. The elastic interaction between the nanotube and its surrounding medium is modeled as a Winkler-Pasternak elastic foundation. The fast convergence of the DQ method is demonstrated and also its accuracy is verified by comparing the results with available solutions in the literature. The effects of various parameters such as different boundary conditions, nonlocal parameter, Winkler and Pasternak elastic modulus, temperature and nanotube curvature on the critical buckling temperature and load are successfully studied. The results reveal that the critical buckling load depends significantly on the curvature of the CCNT.

  13. Polarized radiation in magnetic white dwarfs

    International Nuclear Information System (INIS)

    Rosi, L.A.; Zimmerman, R.L.; Kemp, J.C.

    1976-01-01

    A model for magnetic white dwarfs is proposed which attributes the partially polarized light to synchrotron radiation. The source of the radiation is relativistic electrons trapped in the magnetosphere of a white dwarf. The white dwarf's magnetic field is assumed to be dipolar. The Stokes parameters for the synchrotron radiation are tabulated as a function of frequency, observer's orientation, and energy and spatial distribution of the relativistic electrons. The results of the synchrotron calculations are applied to the polarization observations of Grw+70degree8247 and DQ Herculis. This model can account for the major features of the polarized radiation coming from these two magnetic white dwarfs. The calculations predict for Grw+70degree8247 that the surface magnetic field is B/sub s/approximately-less-than4 x 10 6 gauss, that the incident viewing angle is 45degreeapproximately-less-thantheta 0 approximately-less-than75degree, and that the electrons are trapped with nearly an isotropic distribution about the white dwarf. For DQ Herculis the surface magnetic field is B/sub s/approximately-less-than7 x 10 6 gauss and the trapped electrons are confined to a dislike region about the white dwarf. For both cases the density of electrons in the magnetosphere falls in the range of 10 5 approximately-less-thannapproximately-less-than10 7 cm -3 with energies of about 4--35 MeV

  14. Common immunogenetic profile in children with multiple autoimmune diseases: the signature of HLA-DQ pleiotropic genes.

    Science.gov (United States)

    Larizza, Daniela; Calcaterra, Valeria; Klersy, Catherine; Badulli, Carla; Caramagna, Claudia; Ricci, Antonio; Brambilla, Paola; Salvaneschi, Laura; Martinetti, Miryam

    2012-09-01

    Type 1 diabetes mellitus (T1DM), celiac disease (CD) and autoimmune thyroid disease (ATD) are autoimmune conditions relatively common in paediatric age and frequently occur in association in the same subject. This event is not by chance and requires an explanation. Here, we studied the distribution of HLA-DQ αβ heterodimers in 334 Italian children with T1DM, ATD and CD alone or in association and in 224 Italian healthy controls. In particular, 164 patients had T1DM (133 alone, 20+ATD, 7+CD and 4+CD+ATD), 118 had ATD (110 alone, 8+CD) and 52 had CD (40 alone, 11+ATD and 1+T1DM). 51 patients suffered from multiple autoimmune diseases. The risk for multiple autoimmune diseases was significantly associated with the increased number of HLA-DQ markers of susceptibility for both T1DM (p = 0.003) and CD (p = 0.006). The presence of one or more diabetogenic DQ molecules significantly increased the probability of developing not only T1DM (p HLA-DQ heterodimers significantly increased the likelihood of developing not only CD (p diseases although with a different risk according to the number and type of susceptible HLA-DQ heterodimers as reported in the algorithm proposed here. It is likely that combinations of DQA1 and DQB1 alleles are the real culprits of the progression towards multiple autoimmune diseases and HLA-DQ genomic typing will improve the capability to predict associated autoimmune diseases in infancy.

  15. Polarization Optics

    OpenAIRE

    Fressengeas, Nicolas

    2010-01-01

    The physics of polarization optics *Polarized light propagation *Partially polarized light; DEA; After a brief introduction to polarization optics, this lecture reviews the basic formalisms for dealing with it: Jones Calculus for totally polarized light and Stokes parameters associated to Mueller Calculus for partially polarized light.

  16. HLA-DR and DQ antigens and anticardiolipin antibodies in women with recurrent spontaneous abortions.

    Science.gov (United States)

    Trabace, S; Nicotra, M; Cappellacci, S; Morellini, M; Muttinelli, C; Sbracia, M; Di Prima, M A; Masala, C

    1991-12-01

    IgG anticardiolipin antibodies (ACL) have been shown to occur in a high proportion of women with repeated unexplained miscarriages. Forty-nine women with unexplained recurrent spontaneous abortions (RSA), previously assayed for the presence of ACL by an enzyme-linked immunoabsorbent assay, were typed for HLA-DR and DQ antigens by the classical microlymphocytotoxicity test. Twenty-five women were positive for ACL and 24 were negative. HLA-DR7 was found in 24.5% of 49 habitually aborting women vs. 28% of healthy controls; but the DR7 frequency was 40% in ACL positive patients vs. 8.3% in ACL negative patients (P = 0.011). These results show that in the Italian population an association between HLA-DR7 antigen and ACL is present in women with unexplained RSA, suggesting that HLA-DR genes might control the susceptibility to specific autoantibody production.

  17. HLA-DR and -DQ alleles in Italian patients with melanoma.

    Science.gov (United States)

    Lulli, P; Grammatico, P; Brioli, G; Catricalà, C; Morellini, M; Roccella, M; Mariani, B; Pennesi, G; Roccella, F; Cappellacci, S; Trabace, S

    1998-03-01

    Controversial data have been reported about HLA alleles and susceptibility to melanoma. Our investigation was undertaken to analyze the relationship between HLA alleles distribution in patients with melanoma and susceptibility to the tumor, in order to study the possible correlation between HLA class II DQA1, DQB1 and DRB1 genes involved in immune recognition, and melanoma, usually considered a highly immunogenic tumor. We therefore typed by means of PCR-SSP (sequence-specific primers) 53 Italian patients and 53 healthy random controls coming from the same geographic area. We observed a decrease of all haplotypes bearing DQB1*0301, DQB1*0302 and DQB1*0303 alleles but not of haplotype DRB1*11;DQA1*0501;DQB1*0301. Our results seem to support the hypothesis of a protective role of some DQ3-bearing haplotypic combinations in melanoma.

  18. Numerical Solution of Stokes Flow in a Circular Cavity Using Mesh-free Local RBF-DQ

    DEFF Research Database (Denmark)

    Kutanaai, S Soleimani; Roshan, Naeem; Vosoughi, A

    2012-01-01

    This work reports the results of a numerical investigation of Stokes flow problem in a circular cavity as an irregular geometry using mesh-free local radial basis function-based differential quadrature (RBF-DQ) method. This method is the combination of differential quadrature approximation of der...

  19. Entropy Generation Due to Natural Convection in a Partially Heated Cavity by Local RBF-DQ Method

    DEFF Research Database (Denmark)

    Soleimani, S.; Qajarjazi, A.; Bararnia, H.

    2011-01-01

    The Local Radial Basis Function-Differential Quadrature (RBF-DQ) method is applied to twodimensional incompressible Navier-Stokes equations in primitive form. Numerical results of heatlines and entropy generation due to heat transfer and fluid friction have been obtained for laminar natural...

  20. HLA class II (DR, DQ, DP) in patients with sarcoidosis: evidence of an increased frequency of DRw6

    DEFF Research Database (Denmark)

    Ødum, Niels; Milman, N; Jakobsen, B K

    1991-01-01

    The distribution of HLA class II (DR, DQ, and DP) antigens was studied in 41 patients with symptomatic sarcoidosis (SA) and ethnically matched healthy controls. HLA-DR, -DQw1 and -DQw3 typings were performed with alloantisera in the conventional microcytotoxic test, whereas -DP typings were done...

  1. Genotype effects and epistasis in type 1 diabetes and HLA-DQ trans dimer associations with disease

    NARCIS (Netherlands)

    Koeleman, BPC; Lie, BA; Undlien, DE; Dudbridge, F; Thorsby, E; de Vries, RRP; Cucca, F; Roep, BO; Giphart, MJ; Todd, JA

    Alleles of HLA class II genes DQB1, DQA1, and DRB1 in the MHC region are major determinants of genetic predisposition to type 1 diabetes (T1D). Several alleles of each of these three loci are associated with susceptibility or protection from disease. In addition, relative risks for some DR-DQ

  2. ACCRETION AND MAGNETIC RECONNECTION IN THE CLASSICAL T TAURI BINARY DQ TAU

    Energy Technology Data Exchange (ETDEWEB)

    Tofflemire, Benjamin M.; Mathieu, Robert D. [Department of Astronomy, University of Wisconsin–Madison, 475 North Charter Street, Madison, WI 53706 (United States); Ardila, David R. [The Aerospace Corporation, M2-266, El Segundo, CA 90245 (United States); Akeson, Rachel L.; Ciardi, David R. [NASA Exoplanet Science Institute, IPAC/Caltech, Pasadena, CA 91125 (United States); Johns-Krull, Christopher [Department of Physics and Astronomy, Rice University, Houston, TX 77005 (United States); Herczeg, Gregory J. [The Kavli Institute for Astronomy and Astrophysics, Peking University, Beijing 100871 (China); Quijano-Vodniza, Alberto [University of Nariño Observatory, Pasto, Nariño (Colombia)

    2017-01-20

    The theory of binary star formation predicts that close binaries ( a < 100 au) will experience periodic pulsed accretion events as streams of material form at the inner edge of a circumbinary disk (CBD), cross a dynamically cleared gap, and feed circumstellar disks or accrete directly onto the stars. The archetype for the pulsed accretion theory is the eccentric, short-period, classical T Tauri binary DQ Tau. Low-cadence (∼daily) broadband photometry has shown brightening events near most periastron passages, just as numerical simulations would predict for an eccentric binary. Magnetic reconnection events (flares) during the collision of stellar magnetospheres near periastron could, however, produce the same periodic, broadband behavior when observed at a one-day cadence. To reveal the dominant physical mechanism seen in DQ Tau’s low-cadence observations, we have obtained continuous, moderate-cadence, multiband photometry over 10 orbital periods, supplemented with 27 nights of minute-cadence photometry centered on four separate periastron passages. While both accretion and stellar flares are present, the dominant timescale and morphology of brightening events are characteristic of accretion. On average, the mass accretion rate increases by a factor of five near periastron, in good agreement with recent models. Large variability is observed in the morphology and amplitude of accretion events from orbit to orbit. We argue that this is due to the absence of stable circumstellar disks around each star, compounded by inhomogeneities at the inner edge of the CBD and within the accretion streams themselves. Quasiperiodic apastron accretion events are also observed, which are not predicted by binary accretion theory.

  3. Resolving incomplete single nucleotide polymorphism tagging of HLA-DQ2.2 for coeliac disease genotyping using digital droplet PCR.

    Science.gov (United States)

    Hardy, M Y; Ontiveros, N; Varney, M D; Tye-Din, J A

    2018-04-01

    A hallmark of coeliac disease (CD) is the exceptionally strong genetic association with HLA-DQ2.5, DQ8, and DQ2.2. HLA typing provides information on CD risk important to both clinicians and researchers. A method that enables simple and fast detection of all CD risk genotypes is particularly desirable for the study of large populations. Single nucleotide polymorphism (SNP)-based HLA typing can detect the CD risk genotypes by detecting a combination of six SNPs but this approach can struggle to resolve HLA-DQ2.2, seen in 4% of European CD patients, because of the low resolution of one negatively predicting SNP. We sought to optimise SNP-based HLA typing by harnessing the additional resolution of digital droplet PCR to resolve HLA-DQ2.2. Here we test this two-step approach in an unselected sample of Mexican DNA and compare its accuracy to DNA typed using traditional exon detection. The addition of digital droplet PCR for samples requiring negative prediction of HLA-DQ2.2 enabled HLA-DQ2.2 to be accurately typed. This technique is a simple addition to a SNP-based typing strategy and enables comprehensive definition of all at-risk HLA genotypes in CD in a timely and cost-effective manner. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  4. HLA-DQ-Gluten Tetramer Blood Test Accurately Identifies Patients With and Without Celiac Disease in Absence of Gluten Consumption.

    Science.gov (United States)

    Sarna, Vikas K; Lundin, Knut E A; Mørkrid, Lars; Qiao, Shuo-Wang; Sollid, Ludvig M; Christophersen, Asbjørn

    2018-03-01

    Celiac disease is characterized by HLA-DQ2/8-restricted responses of CD4+ T cells to cereal gluten proteins. A diagnosis of celiac disease based on serologic and histologic evidence requires patients to be on gluten-containing diets. The growing number of individuals adhering to a gluten-free diet (GFD) without exclusion of celiac disease complicates its detection. HLA-DQ-gluten tetramers can be used to detect gluten-specific T cells in blood of patients with celiac disease, even if they are on a GFD. We investigated whether an HLA-DQ-gluten tetramer-based assay accurately identifies patients with celiac disease. We produced HLA-DQ-gluten tetramers and added them to peripheral blood mononuclear cells isolated from 143 HLA-DQ2.5 + subjects (62 subjects with celiac disease on a GFD, 19 subjects without celiac disease on a GFD [due to self-reported gluten sensitivity], 10 subjects with celiac disease on a gluten-containing diet, and 52 presumed healthy individuals [controls]). T cells that bound HLA-DQ-gluten tetramers were quantified by flow cytometry. Laboratory tests and flow cytometry gating analyses were performed by researchers blinded to sample type, except for samples from subjects with celiac disease on a gluten-containing diet. Test precision analyses were performed using samples from 10 subjects. For the HLA-DQ-gluten tetramer-based assay, we combined flow-cytometry variables in a multiple regression model that identified individuals with celiac disease on a GFD with an area under the receiver operating characteristic curve value of 0.96 (95% confidence interval [CI] 0.89-1.00) vs subjects without celiac disease on a GFD. The assay detected individuals with celiac disease on a gluten-containing diet vs controls with an area under the receiver operating characteristic curve value of 0.95 (95% CI 0.90-1.00). Optimized cutoff values identified subjects with celiac disease on a GFD with 97% sensitivity (95% CI 0.92-1.00) and 95% specificity (95% CI 0

  5. Spectrochemical Series and the Dependence of Racah and 10Dq Parameters on the Metal−Ligand Distance: Microscopic Origin

    DEFF Research Database (Denmark)

    Trueba, A.; Garcia-Fernandez, P.; García Lastra, Juan Maria

    2011-01-01

    periodic and cluster calculations have been performed. An analysis of ab initio results proves that 10Dq values mostly come from the small admixture of deep nLs ligand orbitals present in the antibonding eg(∼x2−y2,3z2−r2) level and not from the dominant covalency with valence nLp ligand orbitals, which......The origin of the spectrochemical series and the different dependence of crystal-field splitting (10Dq) and Racah parameters on the metal−ligand distance, R, is explored through ab initio calculations on Cr3+-doped K2NaScF6, Cs2NaYCl6, Cs2NaYBr6, and Cs2NaYI6 lattices. For this purpose both...

  6. Characterizing the binding motifs of 11 common human HLA‐DP and HLA‐DQ molecules using NNAlign

    DEFF Research Database (Denmark)

    Andreatta, Massimo; Nielsen, Morten

    2012-01-01

    in the pattern of amino acid preferences at core positions, with conserved hydrophobic/aromatic anchors at P1 and P6, and an additional hydrophobic anchor at P9 in some variants. These results confirm the existence of a previously hypothesized supertype encompassing the most common DP alleles. Conversely...... and the relative weight of different amino acids at a given position. The recent publication of larger data sets of peptide‐binding to DP and DQ molecules opens the possibility of using data‐driven bioinformatics methods to accurately define the binding motifs of these molecules. Using the neural network......, the binding motifs for DQ molecules appear more divergent, displaying unconventional anchor positions and in some cases rather unspecific amino acid preferences....

  7. Associations of HLA DR and DQ molecules with Lyme borreliosis in Latvian patients

    Directory of Open Access Journals (Sweden)

    Kovalchuka Lilija

    2012-08-01

    Full Text Available Abstract Background Many autoimmune diseases are associated with variants of HLA genes such as those encoding the MHC complex. This correlation is not absolute, but may help in understanding of the molecular mechanism of disease. The purpose of this study was to determine HLA-DR,-DQ alleles in Latvian patients with Lyme borreliosis and control (healthy persons. Case patients and control subjects were similar in age, gender and ethnic heritage and differed only as regards the presence of Borrelia burgdorferi infection. The study included 25 patients with clinical stage – erythema migrans and 30 control (healthy persons. HLA genotyping was performed by PCR with sequence-specific primers. Results The results show difference in HLA-DRB1 alleles distribution between patients and control subjects. The frequencies of HLA-DRB1 *04 (OR 11.24; p  Conclusions HLA predisposition to Lyme borreliosis appears not to be limited to HLA molecules, but some HLA-DR alleles also have a significant influence, and, may have implications in our understanding of pathogenesis of this disease. In particular, HLA-DRB1*04 and DRB1 *17 (03 may contribute to the Lyme borreliosis development in Latvian population

  8. IUE observations of DQ Herculis and its nebula, and the nature of the cold nova shells

    Science.gov (United States)

    Ferland, G. J.; Williams, R. E.; Lambert, D. L.; Slovak, M.; Gondhalekar, P. M.; Truran, J. W.; Shields, G. A.

    1984-01-01

    The nebula ejected in the 1934 outburst of the classical nova DQ Her is remarkable for its unprecedentedly low temperature of Te 500 K as measured by Williams et al. (1978). In this paper, IUE observations are combined with Steward optical spectra. It is confirmed that the gas is quite cold. It is further shown that the gas is ionized by the radiation field of the central object. X-ray, ultraviolet, optical and infrared observations of the underlying binary are combined with the extreme-ultraviolet continuum deduced from the level of ionization of the nebula to obtain a composite energy distribution for the central object. This energy distribution bears no resemblance to that predicted by theoretical models of accretion disks. Photoionization models of the nebula using the deduced continuum, as well as theoretical accretion disk continua, are presented to show that the low electron temperature is the result of the very high metal abundances which characterize nova shells. Infrared fine-structure lines are efficient coolants, and low temperatures are achieved for a wide variety of radiation fields. The implications of these results for nebulae surrounding other old novae are discussed.

  9. HLA-DRB1 shared epitope-dependent DR-DQ haplotypes are associated with both anti-CCP-positive and -negative rheumatoid arthritis in Chinese Han.

    Directory of Open Access Journals (Sweden)

    Xu Liu

    Full Text Available The association between Human Leukocyte Antigen (HLA class II and rheumatoid arthritis (RA has been extensively studied, but few reported DR-DQ haplotype. Here we investigated the association of HLA-DRB1, DQA1, DQB1, and DR-DQ haplotypes with RA susceptibility and with anti-CCP antibodies in 281 RA patients and 297 control in Han population. High-resolution genotyping were performed. The HLA-DRB1 shared epitope (SE-encoding allele *0405 displayed the most significant RA association (P = 1.35×10(-6. The grouped DRB1 SE alleles showed great association with RA (P = 3.88×10(-13. The DRB1 DRRAA alleles displayed significant protective effects (P = 0.021. The SE-dependent DR-DQ haplotype SE-DQ3/4/5 remained strong association with both anti-CCP -positive (P = 3.71×10(-13 and -negative RA (P = 3.89×10(-5. Our study revealed that SE alleles and its haplotypes SE-DQ3/4/5 were highly associated with RA susceptibility in Han population. The SE-DQ3/4/5 haplotypes were associated with both anti-CCP positive RA and -negative RA.

  10. Mass spectrometry-assisted identification of ADAMTS13-derived peptides presented on HLA-DR and HLA-DQ.

    Science.gov (United States)

    Hrdinová, Johana; Verbij, Fabian C; Kaijen, Paul H P; Hartholt, Robin B; van Alphen, Floris; Lardy, Neubury; Ten Brinke, Anja; Vanhoorelbeke, Karen; Hindocha, Pooja J; De Groot, Anne S; Meijer, Alexander B; Voorberg, Jan; Peyron, Ivan

    2018-03-22

    Formation of microthrombi is a hallmark of acquired thrombotic thrombocytopenic purpura. These microthrombi originate from insufficient processing of ultra large von Willebrand factor multimers by ADAMTS13 due to the development of anti-ADAMTS13 autoantibodies. Several studies have identified the major histocompatibility complex class II alleles HLA-DRB1*11, HLA-DQB1*03 and HLA-DQB1*02:02 as risk factors for acquired thrombotic thrombocytopenic purpura development. Previous research in our department indicated that ADAMTS13 CUB2 domain-derived peptides FINVAPHAR and LIRDTHSLR are presented on HLA-DRB1*11 and HLA-DRB1*03, respectively. Here, we describe the repertoire of ADAMTS13 peptides presented on HLA-DQ. In parallel, the repertoire of ADAMTS13-derived peptides presented on HLA-DR was monitored. Using HLA-DR- and HLA-DQ-specific antibodies we purified HLA/peptide complexes from ADAMTS13-pulsed monocyte-derived dendritic cells. Using this approach, we identified ADAMTS13-derived peptides presented on HLA-DR for all 9 samples analyzed; ADAMTS13-derived peptides presented on HLA-DQ were identified in 4 out of 9 samples. We were able to confirm the presentation of the CUB2 domain-derived peptides FINVAPHAR and LIRDTHSLR on HLA-DR. In total 12 different core-peptide sequences were identified on HLA-DR and 8 on HLA-DQ. For HLA-DR11 several potential new core-peptides were found; 4 novel core-peptides were exclusively identified on HLA-DQ. Furthermore, an in silico analysis was performed using the EpiMatrix and JanusMatrix tools to evaluate the eluted peptides, in the context of HLA-DR, for putative effector or regulatory T cell responses at the population level. The results from this study provide a basis for the identification of immuno-dominant epitopes on ADAMTS13 involved in the onset of acquired thrombotic thrombocytopenic purpura. Copyright © 2018, Ferrata Storti Foundation.

  11. HLA-DQ Haplotypes Differ by Ethnicity in Patients with Childhood-onset Diabetes

    Science.gov (United States)

    Lipton, Rebecca B.; Drum, Melinda; Greeley, Siri Atma W.; Danielson, Kirstie K.; Bell, Graeme I.; Hagopian, William A.

    2012-01-01

    Aim To understand the etiology of childhood-onset diabetes, we examined genetic risk markers, autoantibodies (AB), and β-cell function in a mixed-race group of young patients. Methods 145 patients aged 0–17 at diagnosis (54% African American, 22% Caucasian, 16% Latino, 8% Mixed-Other) were studied at mean duration 6.9 ± 5.7 (range 0.1–28.5) years, including HLA-DQA1-DQB1 genotyping, stimulated C-peptide (CP), GAD and IA-2 antibodies (AB). Based on no residual β-cell function (CP−) and islet autoantibodies (AB+), 111 patients were classified with type 1 diabetes (T1DM); 22 were CP+ and AB− and thus considered to have type 2 diabetes (T2DM); 12 patients had features of both T1DM and T2DM, or mixed phenotype. Results Based on the presence of two high-risk HLA-DQA1/B1 haplotypes, 39% of African Americans, 81% of Caucasians, 70% of Latinos, and 67% of Mixed-Others, were at high genetic risk. In T1DM patients, 41% of African Americans, 80% of Caucasians, 73% of Latinos, and 63% of Mixed-Others were genetically susceptible. 31% of African Americans, including 29% of those with T1DM, could not be characterized because their haplotypes had unknown T1DM associations. These unusual haplotypes comprised 11% in T1DM, 14% in T2DM, and 8% of haplotypes in mixed phenotype patients. Conclusions 59% of childhood-onset T1DM patients were identified with high genetic risk based on known HLA-DQA1/B1 associations. Many non-Caucasian patients carry HLA-DQ alleles whose association with T1DM is undetermined. Genetic approaches can provide insights into the etiology and appropriate treatment of childhood-onset diabetes, but only if sufficient data are available in diverse ethnic groups. PMID:21418452

  12. Comparative profiling of HLA-DR and HLA-DQ associated factor VIII peptides presented by monocyte-derived dendritic cells.

    Science.gov (United States)

    Peyron, Ivan; Hartholt, Robin B; Pedró-Cos, Laura; van Alphen, Floris; Brinke, Anja Ten; Lardy, Neubury; Meijer, Alexander B; Voorberg, Jan

    2018-01-01

    The development of anti-factor VIII antibodies is a major complication of the treatment of patients with hemophilia A. Generation of high affinity anti-factor VIII antibodies is dependent on help provided by CD4 + T cells that recognize factor VIII-derived peptides presented on class II major histocompatibility complex on the surface of antigen-presenting cells. In order to identify the immune-dominant epitopes that can be presented to CD4 + T cells, we previously developed a mass spectrometry-based method to identify factor VIII-derived peptides that are presented on human leukocyte antigen (HLA)-DR. In the present work, we compared the repertoire of FVIII-derived peptide presented on HLA-DR and HLA-DQ. Monocyte-derived dendritic cells from nine HLA-typed healthy donors were pulsed with recombinant factor VIII. HLA-DR and HLA-DQ molecules were purified using monoclonal antibodies. Our data show that HLA-DQ and HLA-DR present a similar repertoire of factor VIII-derived peptides. However, the number of peptides associated with HLA-DQ was lower than that with HLA-DR. We also identified a peptide, within the acidic a3 domains of factor VIII, which is presented with higher frequency on HLA-DQ. Interestingly, this peptide was found to have a higher predicted affinity for HLA-DQ than for HLA-DR. Taken together, our data suggest that HLA-DQ participates in the presentation of factor VIII peptides, thereby contributing to the development of inhibitory antibodies in a proportion of patients with severe hemophilia A. Copyright© 2018 Ferrata Storti Foundation.

  13. Binding of peptides from the N-terminal region of alpha-gliadin to the celiac disease-associated HLA-DQ2 molecule assessed in biochemical and T cell assays

    DEFF Research Database (Denmark)

    Johansen, B H; Gjertsen, H A; Vartdal, F

    1996-01-01

    -purified DQ2 and DR3 (i.e., DR(alpha, beta1*0301)) molecules. The peptides were also tested for binding to DQ2 in a functional binding assay, where binding was measured as the capacity to inhibit the stimulation of a gliadin-specific, DQ2-restricted T lymphocyte clone RNnTalpha33. In both assay systems...... here provide new methods for the screening of potentially toxic peptides....

  14. HLA-DQ haplotypes differ by ethnicity in patients with childhood-onset diabetes.

    Science.gov (United States)

    Lipton, Rebecca B; Drum, Melinda; Greeley, Siri Atma W; Danielson, Kirstie K; Bell, Graeme I; Hagopian, William A

    2011-06-01

    To understand the etiology of childhood-onset diabetes, we examined genetic risk markers, autoantibodies, and β-cell function in a mixed race group of young patients. One hundred and forty-five patients aged 0-17 at diagnosis (54% African American, 22% Caucasian, 16% Latino, 8% mixed-other) were studied at mean duration 6.9 ± 5.7 (range 0.1-28.5) yr, including human leukocyte antigen (HLA)-DQA1-DQB1 genotyping, stimulated C peptide (CP), glutamic acid decarboxylase, and insulinoma-associated antigen 2 antibodies (ABs). Based on no residual β-cell function (CP-) and islet autoantibodies (AB+), 111 patients were classified with type 1 diabetes mellitus (T1DM), 22 were CP+ and AB- and thus considered to have type 2 diabetes mellitus (T2DM), and 12 patients had features of both T1DM and T2DM or mixed phenotype. Based on the presence of two high-risk HLA-DQA1/B1 haplotypes, 39% of African Americans, 81% of Caucasians, 70% of Latinos, and 67% of mixed-others were at high genetic risk. In patients with T1DM, 41% of African Americans, 80% of Caucasians, 73% of Latinos, and 63% of mixed-others were genetically susceptible. Thirty-one percent of African Americans, including 29% of those with T1DM, could not be characterized because their haplotypes had unknown T1DM associations. These unusual haplotypes comprised 11% in T1DM, 14% in T2DM, and 8% in patients with mixed phenotype. Fifty-nine percent of childhood-onset patients with T1DM were identified with high genetic risk based on known HLA-DQA1/B1 associations. Many non-Caucasian patients carry HLA-DQ alleles whose association with T1DM is undetermined. Genetic approaches can provide insights into the etiology and appropriate treatment of childhood-onset diabetes but only if sufficient data are available in diverse ethnic groups. © 2011 John Wiley & Sons A/S.

  15. HLA class I (-A, -B, -C) and class II (-DR, -DQ) polymorphism in the Mauritanian population.

    Science.gov (United States)

    Hamed, Cheikh Tijani; Meiloud, Ghlana; Veten, Fatimetou; Hadrami, Mouna; Ghaber, Sidi M; Boussaty, Ely C; Habti, Norddine; Houmeida, Ahmed

    2018-01-03

    HLA antigens have been widely studied for their role in transplantation biology, human diseases and population diversity. The aim of this study was to provide the first profile of HLA class I and class II alleles in the Mauritanian population. HLA typing was carried in 93 healthy Mauritanian blood donors, using single specific primer amplification (PCR-SSP). Occurrences of the main HLA class I (-A, -B, -C) and class II (-DR, -DQ) antigens in the general population showed that out of the 17 HLA-A allele groups detected, five main HLA-A allele groups: A*02 (18.42%), A*01 (14.04%), A*23 (14.04%), A*30 (13.16%) and A*29 (12.28%) were the most common identified along other 12 relatively minor allele groups. Twenty three allele groups were observed in the locus B of which B*07 (13.46%) was the most prevalent followed by B*15, B*35, B*08 and B*27 all, with a frequency between 7 to 8%. Three prevalent HLA-C allele groups (C*02: 35.09%, C*07: 20.19% and C*06: 13.6%) were detected. The main HLA class II observed allele groups were: DRB1*13 (27.42%), DRB1*03 (24.73%), DRB1*11 (13.98%), DQB1*03 (36.03%), DQB1*02 (22.06%) and DQB1*05 (18.8%). Except for few haplotype in class I (A*02-B*07: 4.45%, A*02-C02: 10%, A*23-C*02: 8.8%, B*07-C*02: 8.8%, B*15-C*02: 8.8%) and in class II (DRB1*13-DQB1*06: 11.94%, DRB1*03-DQB1*02:11.19% and DRB1*03-DQB1*03: 10.45%), the majority of locus combination were in the range of 2-3%. A single predominant haplotype C*02-DRB1*03 (16.67%) was found. These results, in agreement with previous data using different tissues markers, underlined the ethnic heterogeneity of the Mauritanian population.

  16. Polarimetry and spectroscopy of the "oxygen flaring" DQ Herculis-like nova: V5668 Sagittarii (2015)

    Science.gov (United States)

    Harvey, E. J.; Redman, M. P.; Darnley, M. J.; Williams, S. C.; Berdyugin, A.; Piirola, V. E.; Fitzgerald, K. P.; O'Connor, E. G. P.

    2018-03-01

    ". Conclusions: V5668 Sgr (2015) was a remarkable nova of the DQ Her class. Changes in absolute polarimetric and spectroscopic multi-epoch observations lead to interpretations of physical characteristics of the nova's evolving outflow. The high densities that were found early-on combined with knowledge of the system's behaviour at other wavelengths and polarimetric measurements strongly suggest that the visual "cusps" are due to radiative shocks between fast and slow ejecta that destroy and create dust seed nuclei cyclically.

  17. Numerical Simulation of Voltage Electric Field in Complex Geometries for Different Electrode Arrangements using Meshless Local MQ-DQ Method

    DEFF Research Database (Denmark)

    Jalaal, M.; Soleimani, Soheil; Domairry, G.

    2011-01-01

    In this paper the meshless Local Multi Quadrics-based Differential Quadrature (MQ-DQ) method is applied to obtain the electric field distribution for different applicable irregular geometries. This method is the combination of Differential Quadrature approximation of derivatives and function...... approximation of MQ-Radial Basis Function (RBF). Three different geometries with irregular boundaries are considered and the obtained results are compared with those gained by Finite Element (FE) solutions achieved by COMSOL commercial code. Outcomes prove that current technique is in very good agreement...

  18. HLA-DP, HLA-DQ, and HLA-DR Have Different Requirements for Invariant Chain and HLA-DM*

    OpenAIRE

    van Lith, Marcel; McEwen-Smith, Rosanna M.; Benham, Adam M.

    2010-01-01

    The MHC is central to the adaptive immune response. The human MHC class II is encoded by three different isotypes, HLA-DR, -DQ, and -DP, each being highly polymorphic. In contrast to HLA-DR, the intracellular assembly and trafficking of HLA-DP molecules have not been studied extensively. However, different HLA-DP variants can be either protective or risk factors for infectious diseases (e.g. hepatitis B), immune dysfunction (e.g. berylliosis), and autoimmunity (e.g. myasthenia gravis). Here, ...

  19. Polarization developments

    International Nuclear Information System (INIS)

    Prescott, C.Y.

    1993-07-01

    Recent developments in laser-driven photoemission sources of polarized electrons have made prospects for highly polarized electron beams in a future linear collider very promising. This talk discusses the experiences with the SLC polarized electron source, the recent progress with research into gallium arsenide and strained gallium arsenide as a photocathode material, and the suitability of these cathode materials for a future linear collider based on the parameters of the several linear collider designs that exist

  20. The distribution of DQ genes in the Saharawi population provides only a partial explanation for the high celiac disease prevalence.

    Science.gov (United States)

    Catassi, C; Doloretta Macis, M; Rätsch, I M; De Virgiliis, S; Cucca, F

    2001-12-01

    Celiac disease (CD) is a multifactorial disorder of the small intestine caused by a permanent dietary intolerance to gluten. The combined presence of the HLA class II DQA1*0501 and DQB1*0201 alleles represents the major genetic component for disease predisposition. It has been shown that the Saharawi refugees living in northern Africa have a very high frequency of CD. In the present study we analysed this population to evaluate the degree of association with CD of the haplotypes and genotypes at the main HLA-DQB1 and DQA1 disease loci. We found a strong association of the DR3, DQB1*0201-DQA1*0501-positive haplotypes and genotypes. A very high frequency of DR3, DQB1*0201-DQA1*0501 was also observed in the general Saharawi population. These results indicate that there is a good correlation between disease prevalence and frequency of the main predisposing haplotype in the background population. However, the correlation is incomplete because similar frequencies of DR3 are also observed in populations such as the Sardinians showing a much lower prevalence of CD. We can conclude that the distribution of DQ genes in the Saharawi population only provides a partial explanation for the high prevalence of CD. Other factors, such as rapidly changing dietary habits and/or non-DQ genes, may also play some role.

  1. Site-specific antibodies distinguish single amino acid substitutions in position 57 in HLA-DQ beta-chain alleles associated with insulin-dependent diabetes

    DEFF Research Database (Denmark)

    Atar, D; Dyrberg, T; Michelsen, Birgitte

    1989-01-01

    The HLA-DQ beta-chain gene shows a close association with susceptibility or resistance to autoimmune insulin-dependent diabetes mellitus (IDDM) and it has been suggested that the amino acid in position 57 may be of pathogenetic importance. To study the expression of the IDDM associated HLA-DQ beta......-chain alleles, we immunized rabbits with 12 to 13 amino acid long peptides representing HLA-DQw7 and -DQw8 allelic sequences, differing only by one amino acid in position 57 being aspartic acid (Asp) and alanine (Ala), respectively. Immunoblot analysis of lymphoblastoid cells showed that several antisera...... amino acid substitutions in predetermined positions of allelic HLA-DQ beta-chain gene products. Such sera should become useful to detect and investigate HLA associated susceptibility to autoimmune diseases in man....

  2. Association of human leukocyte antigen (HLA)-DQ and HLA-DQA1/DQB1 alleles with Vogt–Koyanagi–Harada disease

    Science.gov (United States)

    Liu, Bing; Deng, Tuo; Zhu, Linxin; Zhong, Jingxiang

    2018-01-01

    Abstract Objective: The aim of this study was to evaluate the association of human leukocyte antigen (HLA)-DQ and HLA-DQA1/DQB1 alleles with Vogt–Koyanagi–Harada (VKH), providing further evidences on the genetic background of this disease. Methods: A comprehensive literature search was conducted on the relationship of HLA-DQ and/or HLA-DQA1/DQB1 alleles with VKH through PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, VIP, and databases for grey literature. The last search was in October 2017. Pooled odds ratio (OR) with 95% confidence interval (95% CI) was calculated from extracted data to access the strength of the association between a genotype and VKH. Results: HLA-DQ4 was confirmed to increase the risk of VKH significantly (OR = 4.63, 95% CI: 1.74–12.31, P = .002), while HLA-DQ1 seemed to reduce VKH occurrence with OR = 0.32 (95% CI: 0.22–0.47, P HLA-DQA1∗0301-(OR = 4.52, 95% CI: 1.42–14.35, P = .01) and HLA-DQB1∗0401-(OR = 23.12, 95% CI: 11.54–46.31, P HLA-DQA1∗0103, 0401, 0501 and HLA-DQB1∗0301, 0402, 0601, 0603 were significant protective genetic factors. Conclusion: We concluded that HLA-DQ4 carriers had a higher risk of VKH and HLA-DQ1 seemed to be protective. People with positive HLA-DQA1∗0301 and HLA-DQB1∗0401 demonstrated to be more susceptible to VKH. HLA-DQA1∗0103, 0401, 0501 and HLA-DQB1∗0301, 0402, 0601, 0603 could be potential protectors. PMID:29443768

  3. Polarization, political

    NARCIS (Netherlands)

    Wojcieszak, M.; Mazzoleni, G.; Barnhurst, K.G.; Ikeda, K.; Maia, R.C.M.; Wessler, H.

    2015-01-01

    Polarization has been studied in three different forms: on a social, group, and individual level. This entry first focuses on the undisputed phenomenon of elite polarization (i.e., increasing adherence of policy positions among the elites) and also outlines different approaches to assessing mass

  4. Polarization holography

    DEFF Research Database (Denmark)

    Nikolova, L.; Ramanujam, P.S.

    Current research into holography is concerned with applications in optically storing, retrieving, and processing information. Polarization holography has many unique properties compared to conventional holography. It gives results in high efficiency, achromaticity, and special polarization...... properties. This books reviews the research carried out in this field over the last 15 years. The authors provide basic concepts in polarization and the propagation of light through anisotropic materials, before presenting a sound theoretical basis for polarization holography. The fabrication...... and characterization of azobenzene based materials, which remain the most efficient for the purpose, is described in detail. This is followed by a description of other materials that are used in polarization holography. An in-depth description of various applications, including display holography and optical storage...

  5. Intermediate algebra a textworkbook

    CERN Document Server

    McKeague, Charles P

    1985-01-01

    Intermediate Algebra: A Text/Workbook, Second Edition focuses on the principles, operations, and approaches involved in intermediate algebra. The publication first takes a look at basic properties and definitions, first-degree equations and inequalities, and exponents and polynomials. Discussions focus on properties of exponents, polynomials, sums, and differences, multiplication of polynomials, inequalities involving absolute value, word problems, first-degree inequalities, real numbers, opposites, reciprocals, and absolute value, and addition and subtraction of real numbers. The text then ex

  6. Intermediate algebra & analytic geometry

    CERN Document Server

    Gondin, William R

    1967-01-01

    Intermediate Algebra & Analytic Geometry Made Simple focuses on the principles, processes, calculations, and methodologies involved in intermediate algebra and analytic geometry. The publication first offers information on linear equations in two unknowns and variables, functions, and graphs. Discussions focus on graphic interpretations, explicit and implicit functions, first quadrant graphs, variables and functions, determinate and indeterminate systems, independent and dependent equations, and defective and redundant systems. The text then examines quadratic equations in one variable, system

  7. Polar Bears

    Science.gov (United States)

    Amstrup, Steven C.; Douglas, David C.; Reynolds, Patricia E.; Rhode, E.B.

    2002-01-01

    Polar bears (Ursus maritimus) are hunted throughout most of their range. In addition to hunting polar bears of the Beaufort Sea region are exposed to mineral and petroleum extraction and related human activities such as shipping road-building, and seismic testing (Stirling 1990).Little was known at the start of this project about how polar bears move about in their environment, and although it was understood that many bears travel across political borders, the boundaries of populations had not been delineated (Amstrup 1986, Amstrup et al. 1986, Amstrup and DeMaster 1988, Garner et al. 1994, Amstrup 1995, Amstrup et al. 1995, Amstrup 2000).As human populations increase and demands for polar bears and other arctic resources escalate, managers must know the sizes and distributions of the polar bear populations. Resource managers also need reliable estimates of breeding rates, reproductive intervals, litter sizes, and survival of young and adults.Our objectives for this research were 1) to determine the seasonal and annual movements of polar bears in the Beaufort Sea, 2) to define the boundaries of the population(s) using this region, 3) to determine the size and status of the Beaufort Sea polar bear population, and 4) to establish reproduction and survival rates (Amstrup 2000).

  8. Binding of peptides from the N-terminal region of alpha-gliadin to the celiac disease-associated HLA-DQ2 molecule assessed in biochemical and T cell assays

    DEFF Research Database (Denmark)

    Johansen, B H; Gjertsen, H A; Vartdal, F

    1996-01-01

    Celiac disease (CD) is most probably an immunological disease, precipitated in susceptible individuals by ingestion of wheat gliadin and related proteins from other cereals. The disease shows a strong HLA association predominantly to the cis- or trans-encoded HLA-DQ(alpha1*0501, beta1*02) (i.e., DQ...

  9. HLA-DQ2.5 genes associated with celiac disease risk are preferentially expressed with respect to non-predisposing HLA genes: Implication for anti-gluten T cell response.

    Science.gov (United States)

    Pisapia, Laura; Camarca, Alessandra; Picascia, Stefania; Bassi, Virginia; Barba, Pasquale; Del Pozzo, Giovanna; Gianfrani, Carmen

    2016-06-01

    HLA genes represent the main risk factor in autoimmune disorders. In celiac disease (CD), the great majority of patients carry the HLA DQA1*05 and DQB1*02 alleles, both of which encode the DQ2.5 molecule. The formation of complexes between DQ2.5 and gluten peptides on antigen-presenting cells (APCs) is necessary to activate pathogenic CD4(+) T lymphocytes. It is widely accepted that the DQ2.5 genes establish the different intensities of anti-gluten immunity, depending whether they are in a homozygous or a heterozygous configuration. Here, we demonstrated that HLA DQA1*05 and DQB1*02 gene expression is much higher than expression of non-CD-associated genes. This influences the protein levels and causes a comparable cell surface exposure of DQ2.5 heterodimers between DQ2.5 homozygous and heterozygous celiac patients. As a consequence, the magnitude of the anti-gluten CD4(+) T cell response is strictly dependent on the antigen dose and not on the DQ2.5 gene configuration of APCs. Furthermore, our findings support the concept that the expression of DQ2.5 genes is an important risk factor in celiac disease. The preferential expression of DQ2.5 alleles provides a new functional explanation of why these genes are so frequently associated with celiac disease and with other autoimmune disorders. Copyright © 2016 Elsevier Ltd. All rights reserved.

  10. HLA-DR7 and HLA-DQ2: Transgenic mouse strains tested as a model system for ximelagatran hepatotoxicity.

    Directory of Open Access Journals (Sweden)

    Hanna Lundgren

    Full Text Available The oral thrombin inhibitor ximelagatran was withdrawn in the late clinical trial phase because it adversely affected the liver. In approximately 8% of treated patients, drug-induced liver injury (DILI was expressed as transient alanine transaminase (ALT elevations. No evidence of DILI had been revealed in the pre-clinical in vivo studies. A whole genome scan study performed on the clinical study material identified a strong genetic association between the major histocompatibility complex alleles for human leucocyte antigens (HLA (HLA-DR7 and HLA-DQ2 and elevated ALT levels in treated patients. An immune-mediated pathogenesis was suggested. Here, we evaluated whether HLA transgenic mice models could be used to investigate whether the expression of relevant HLA molecules was enough to reproduce the DILI effects in humans. In silico modelling performed in this study revealed association of both ximelagatran (pro-drug and melagatran (active drug to the antigen-presenting groove of the homology modelled HLA-DR7 molecule suggesting "altered repertoire" as a key initiating event driving development of DILI in humans. Transgenic mouse strains (tgms expressing HLA of serotype HLA-DR7 (HLA-DRB1*0701, -DRA*0102, and HLA-DQ2 (HLA-DQB1*0202,-DQA1*0201 were created. These two lines were crossed with a human (hCD4 transgenic line, generating the two tgms DR7xhCD4 and DQ2xhCD4. To investigate whether the DILI effects observed in humans could be reproduced in tgms, the mice were treated for 28 days with ximelagatran. Results revealed no signs of DILI when biomarkers for liver toxicity were measured and histopathology was evaluated. In the ximelagatran case, presence of relevant HLA-expression in a pre-clinical model did not fulfil the prerequisite for reproducing DILI observed in patients. Nonetheless, for the first time an HLA-transgenic mouse model has been investigated for use in HLA-associated DILI induced by a low molecular weight compound. This study

  11. Association of HLA-DP/DQ and STAT4 polymorphisms with HBV infection outcomes and a mini meta-analysis.

    Directory of Open Access Journals (Sweden)

    Yun Liao

    Full Text Available BACKGROUND: Though HLA-DP/DQ is regarded to associate with HBV susceptibility and HBV natural clearance, its role in hepatocellular carcinoma (HCC development is obscure. And the role of STAT4 in HBV susceptibility and clearance as well as HCC development is still contentious. Therefore, we conducted this study, aiming to clarify these obscure relationships. METHODS: We recruited 1312 Chinese Han subjects including healthy controls, HBV carriers and HCC patients in the experiment stage. The meta-analysis included 3467 HCC patients and 5821 HBV carriers to appraise the association with HCC development. RESULTS: Consistent with previous studies, HLA-DP/DQ associated with HBV susceptibility and HBV natural clearance (p<0.05. However, the experiment showed that HLA-DP rs3077, rs9277535 and rs7453920 did not associate with HCC development (dominant model, rs3077, OR = 0.86, 95%CI = 0.62-1.18; rs9277535, OR = 0.94, 95%CI = 0.68-1.30; rs7453920, OR = 0.75, 95%CI = 0.44-1.27. Meta-analysis again consolidated this conclusion (allele model, rs3077, OR = 0.94, 95%CI = 0.87-1.02; rs9277535, OR = 1.04, 95%CI = 0.97-1.11; rs7453920, OR = 0.89, 95%CI = 0.76-1.02. As for STAT4 rs7574865, we did not find any significant association with HBV susceptibility (OR = 0.91, 95%CI = 0.66-1.26 or HBV natural clearance (OR = 1.13, 95%CI = 0.86-1.49. Moreover, current data failed to acquire positive connection of rs7574865 with HCC development (experiment, OR = 0.86, 95%CI = 0.62-1.19; meta-analysis, OR = 0.87, 95%CI = 0.74-1.03, which may be due to the small sample size. CONCLUSIONS: HLA-DP/DQ polymorphisms (rs3077, rs9277535, rs7453920 did not associate with HCC development, but did correlate with HBV susceptibility and HBV natural clearance. STAT4 rs7574865 seemed not to correlate with HBV susceptibility or natural clearance. And it seemed rather ambiguous in its role on HCC development at

  12. The Clinical Course of Patients with Preschool Manifestation of Type 1 Diabetes Is Independent of the HLA DR-DQ Genotype

    Directory of Open Access Journals (Sweden)

    Christina Reinauer

    2017-05-01

    Full Text Available Introduction: Major histocompatibility complex class II genes are considered major genetic risk factors for autoimmune diabetes. We analysed Human Leukocyte Antigen (HLA DR and DQ haplotypes in a cohort with early-onset (age < 5 years, long term type 1 diabetes (T1D and explored their influence on clinical and laboratory parameters. Methods: Intermediate resolution HLA-DRB1, DQA1 and DQB1 typing was performed in 233 samples from the German Paediatric Diabetes Biobank and compared with a local control cohort of 19,544 cases. Clinical follow-up data of 195 patients (diabetes duration 14.2 ± 2.9 years and residual C-peptide levels were compared between three HLA risk groups using multiple linear regression analysis. Results: Genetic variability was low, 44.6% (104/233 of early-onset T1D patients carried the highest-risk genotype HLA-DRB1*03:01-DQA1*05:01-DQB1*02:01/DRB1*04-DQA1*03:01-DQB1*03:02 (HLA-DRB1*04 denoting 04:01/02/04/05, and 231 of 233 individuals carried at least one of six risk haplotypes. Comparing clinical data between the highest (n = 83, moderate (n = 106 and low risk (n = 6 genotypes, we found no difference in age at diagnosis (mean age 2.8 ± 1.1 vs. 2.8 ± 1.2 vs. 3.2 ± 1.5 years, metabolic control, or frequency of associated autoimmune diseases between HLA risk groups (each p > 0.05. Residual C-peptide was detectable in 23.5% and C-peptide levels in the highest-risk group were comparable to levels in moderate to high risk genotypes. Conclusion: In this study, we saw no evidence for a different clinical course of early-onset T1D based on the HLA genotype within the first ten years after manifestation.

  13. Intermediate energy proton and light-ion scattering

    International Nuclear Information System (INIS)

    Moss, J.M.

    1981-01-01

    A review is presented of recent (1979-81) developments in the field of intermediate-energy proton and light-ion scattering from nuclei. New theoretical and calculational techniques of particular interest to experimentalists are discussed. Emphasis is placed on topics in nuclear structure physics - giant resonances, pion-condensation precursor phenomena, and polarization transfer (spin-flip) experiments - where intermediate energy proton and light-ion scattering has made new and unique contributions

  14. Assessing high affinity binding to HLA-DQ2.5 by a novel peptide library based approach

    DEFF Research Database (Denmark)

    Jüse, Ulrike; Arntzen, Magnus; Højrup, Peter

    2011-01-01

    Here we report on a novel peptide library based method for HLA class II binding motif identification. The approach is based on water soluble HLA class II molecules and soluble dedicated peptide libraries. A high number of different synthetic peptides are competing to interact with a limited amount...... library. The eluted sequences fit very well with the previously described HLA-DQ2.5 peptide binding motif. This novel method, limited by library complexity and sensitivity of mass spectrometry, allows the analysis of several thousand synthetic sequences concomitantly in a simple water soluble format....... of HLA molecules, giving a selective force in the binding. The peptide libraries can be designed so that the sequence length, the alignment of binding registers, the numbers and composition of random positions are controlled, and also modified amino acids can be included. Selected library peptides bound...

  15. Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk

    NARCIS (Netherlands)

    Hu, Xinli; Deutsch, Aaron J; Lenz, Tobias L; Onengut-Gumuscu, Suna; Han, Buhm; Chen, Wei-Min; Howson, Joanna M M; Todd, John A; de Bakker, Paul I W; Rich, Stephen S; Raychaudhuri, Soumya

    Variation in the human leukocyte antigen (HLA) genes accounts for one-half of the genetic risk in type 1 diabetes (T1D). Amino acid changes in the HLA-DR and HLA-DQ molecules mediate most of the risk, but extensive linkage disequilibrium complicates the localization of independent effects. Using

  16. During Stably Suppressive Antiretroviral Therapy Integrated HIV-1 DNA Load in Peripheral Blood is Associated with the Frequency of CD8 Cells Expressing HLA-DR/DP/DQ

    Directory of Open Access Journals (Sweden)

    Alessandra Ruggiero

    2015-09-01

    Conclusions: The observed positive association between integrated HIV-1 DNA load and frequency of CD8+DR/DP/DQ+ cells indicates that a close correlation between HIV persistence and immune activation continues during consistently suppressive therapy. The inducers of the distinct activation profile warrant further investigation.

  17. Locus-specific detection of HLA-DQ and -DR antigens by antibodies against synthetic N-terminal octapeptides of the beta chain

    DEFF Research Database (Denmark)

    Deufel, T; Grove, A; Kofod, Hans

    1985-01-01

    Antibodies against synthetic peptides representing the class-II antigen HLA-DR and -DQ beta chain N-terminal sequences were prepared in rabbits. The two octapeptides only share two amino acids and enzyme-linked immuno-assays showed the antisera only to bind to its own antigen. Both peptide antisera...

  18. Study on intermediate species of polystyrene by using pulse radiolysis

    Energy Technology Data Exchange (ETDEWEB)

    Okamoto, K.; Saeki, A.; Kozawa, T.; Miyako, Miki; Tagawa, S. [Osaka Univ., Ibaraki (Japan). Inst. of Scientific and Industrial Research

    2000-03-01

    The reaction mechanism of intermediates of polystyrene solutions in cyclohexane and chlorinated hydrocarbon solvents has been studied by using pulse radiolysis. Absorption peaks observed around 1250 {approx} 1350 nm in chlorinated hydrocarbon and cyclohexane solutions of polystyrene, were identified with the dimer cation radicals of polystyrene. The absorption intensities of polystyrene dimer cation radicals were enhanced with increasing of polarities of solvents. Because free ion yields of polystyrene cation radicals were increased with increasing of polarities. (author)

  19. Mobile communication and intermediality

    DEFF Research Database (Denmark)

    Helles, Rasmus

    2013-01-01

    The article argues the importance of intermediality as a concept for research in mobile communication and media. The constant availability of several, partially overlapping channels for communication (texting, calls, email, Facebook, etc.) requires that we adopt an integrated view of the various...

  20. an intermediate moisture meat

    African Journals Online (AJOL)

    Bunmi

    Matured leaves of Ocimum gratissimum were harvested and the extracts used to cure. Suya (an intermediate moisture meat). O. gratissimum leaves were collected from. Oyo state south west region of Nigeria, rinsed in distilled water and squeezed to extract the fluid. The meat used was Semi membranosus muscle from beef ...

  1. The Spin Pulse of the Intermediate Polar V1062 Tauri

    Science.gov (United States)

    Hellier, Coel; Beardmore, A. P.; Mukai, Koji; White, Nicholas E. (Technical Monitor)

    2002-01-01

    We combine ASCA and RXTE data of V1062 Tau to confirm the presence of a 62-min X-ray pulsation. We show that the pulsation is caused largely by the variation of dense partial absorption, in keeping with current models of accretion onto magnetic white dwarfs. Further parameterisation of the spin pulse is, however, hampered by ambiguities in the models.

  2. Experiments in intermediate energy physics

    Energy Technology Data Exchange (ETDEWEB)

    Dehnhard, D.

    2003-02-28

    Research in experimental nuclear physics was done from 1979 to 2002 primarily at intermediate energy facilities that provide pion, proton, and kaon beams. Particularly successful has been the work at the Los Alamos Meson Physics Facility (LAMPF) on unraveling the neutron and proton contributions to nuclear ground state and transition densities. This work was done on a wide variety of nuclei and with great detail on the carbon, oxygen, and helium isotopes. Some of the investigations involved the use of polarized targets which allowed the extraction of information on the spin-dependent part of the triangle-nucleon interaction. At the Indiana University Cyclotron Facility (IUCF) we studied proton-induced charge exchange reactions with results of importance to astrophysics and the nuclear few-body problem. During the first few years, the analysis of heavy-ion nucleus scattering data that had been taken prior to 1979 was completed. During the last few years we created hypernuclei by use of a kaon beam at Brookhaven National Laboratory (BNL) and an electron beam at Jefferson Laboratory (JLab). The data taken at BNL for a study of the non-mesonic weak decay of the A particle in a nucleus are still under analysis by our collaborators. The work at JLab resulted in the best resolution hypernuclear spectra measured thus far with magnetic spectrometers.

  3. The Intermediate Neutrino Program

    Energy Technology Data Exchange (ETDEWEB)

    Adams, C.; et al.

    2015-03-23

    The US neutrino community gathered at the Workshop on the Intermediate Neutrino Program (WINP) at Brookhaven National Laboratory February 4-6, 2015 to explore opportunities in neutrino physics over the next five to ten years. Scientists from particle, astroparticle and nuclear physics participated in the workshop. The workshop examined promising opportunities for neutrino physics in the intermediate term, including possible new small to mid-scale experiments, US contributions to large experiments, upgrades to existing experiments, R&D plans and theory. The workshop was organized into two sets of parallel working group sessions, divided by physics topics and technology. Physics working groups covered topics on Sterile Neutrinos, Neutrino Mixing, Neutrino Interactions, Neutrino Properties and Astrophysical Neutrinos. Technology sessions were organized into Theory, Short-Baseline Accelerator Neutrinos, Reactor Neutrinos, Detector R&D and Source, Cyclotron and Meson Decay at Rest sessions.This report summarizes discussion and conclusions from the workshop.

  4. The Intermediate Neutrino Program

    CERN Document Server

    Adams, C.; Ankowski, A.M.; Asaadi, J.A.; Ashenfelter, J.; Axani, S.N.; Babu, K.; Backhouse, C.; Band, H.R.; Barbeau, P.S.; Barros, N.; Bernstein, A.; Betancourt, M.; Bishai, M.; Blucher, E.; Bouffard, J.; Bowden, N.; Brice, S.; Bryan, C.; Camilleri, L.; Cao, J.; Carlson, J.; Carr, R.E.; Chatterjee, A.; Chen, M.; Chen, S.; Chiu, M.; Church, E.D.; Collar, J.I.; Collin, G.; Conrad, J.M.; Convery, M.R.; Cooper, R.L.; Cowen, D.; Davoudiasl, H.; de Gouvea, A.; Dean, D.J.; Deichert, G.; Descamps, F.; DeYoung, T.; Diwan, M.V.; Djurcic, Z.; Dolinski, M.J.; Dolph, J.; Donnelly, B.; Dwyer, D.A.; Dytman, S.; Efremenko, Y.; Everett, L.L.; Fava, A.; Figueroa-Feliciano, E.; Fleming, B.; Friedland, A.; Fujikawa, B.K.; Gaisser, T.K.; Galeazzi, M.; Galehouse, D.C.; Galindo-Uribarri, A.; Garvey, G.T.; Gautam, S.; Gilje, K.E.; Gonzalez-Garcia, M.; Goodman, M.C.; Gordon, H.; Gramellini, E.; Green, M.P.; Guglielmi, A.; Hackenburg, R.W.; Hackenburg, A.; Halzen, F.; Han, K.; Hans, S.; Harris, D.; Heeger, K.M.; Herman, M.; Hill, R.; Holin, A.; Huber, P.; Jaffe, D.E.; Johnson, R.A.; Joshi, J.; Karagiorgi, G.; Kaufman, L.J.; Kayser, B.; Kettell, S.H.; Kirby, B.J.; Klein, J.R.; Kolomensky, Yu. G.; Kriske, R.M.; Lane, C.E.; Langford, T.J.; Lankford, A.; Lau, K.; Learned, J.G.; Ling, J.; Link, J.M.; Lissauer, D.; Littenberg, L.; Littlejohn, B.R.; Lockwitz, S.; Lokajicek, M.; Louis, W.C.; Luk, K.; Lykken, J.; Marciano, W.J.; Maricic, J.; Markoff, D.M.; Martinez Caicedo, D.A.; Mauger, C.; Mavrokoridis, K.; McCluskey, E.; McKeen, D.; McKeown, R.; Mills, G.; Mocioiu, I.; Monreal, B.; Mooney, M.R.; Morfin, J.G.; Mumm, P.; Napolitano, J.; Neilson, R.; Nelson, J.K.; Nessi, M.; Norcini, D.; Nova, F.; Nygren, D.R.; Orebi Gann, G.D.; Palamara, O.; Parsa, Z.; Patterson, R.; Paul, P.; Pocar, A.; Qian, X.; Raaf, J.L.; Rameika, R.; Ranucci, G.; Ray, H.; Reyna, D.; Rich, G.C.; Rodrigues, P.; Romero, E.Romero; Rosero, R.; Rountree, S.D.; Rybolt, B.; Sanchez, M.C.; Santucci, G.; Schmitz, D.; Scholberg, K.; Seckel, D.; Shaevitz, M.; Shrock, R.; Smy, M.B.; Soderberg, M.; Sonzogni, A.; Sousa, A.B.; Spitz, J.; St. John, J.M.; Stewart, J.; Strait, J.B.; Sullivan, G.; Svoboda, R.; Szelc, A.M.; Tayloe, R.; Thomson, M.A.; Toups, M.; Vacheret, A.; Vagins, M.; Van de Water, R.G.; Vogelaar, R.B.; Weber, M.; Weng, W.; Wetstein, M.; White, C.; White, B.R.; Whitehead, L.; Whittington, D.W.; Wilking, M.J.; Wilson, R.J.; Wilson, P.; Winklehner, D.; Winn, D.R.; Worcester, E.; Yang, L.; Yeh, M.; Yokley, Z.W.; Yoo, J.; Yu, B.; Yu, J.; Zhang, C.

    2015-01-01

    The US neutrino community gathered at the Workshop on the Intermediate Neutrino Program (WINP) at Brookhaven National Laboratory February 4-6, 2015 to explore opportunities in neutrino physics over the next five to ten years. Scientists from particle, astroparticle and nuclear physics participated in the workshop. The workshop examined promising opportunities for neutrino physics in the intermediate term, including possible new small to mid-scale experiments, US contributions to large experiments, upgrades to existing experiments, R&D plans and theory. The workshop was organized into two sets of parallel working group sessions, divided by physics topics and technology. Physics working groups covered topics on Sterile Neutrinos, Neutrino Mixing, Neutrino Interactions, Neutrino Properties and Astrophysical Neutrinos. Technology sessions were organized into Theory, Short-Baseline Accelerator Neutrinos, Reactor Neutrinos, Detector R&D and Source, Cyclotron and Meson Decay at Rest sessions.This report summ...

  5. The Intermediate Neutrino Program

    Energy Technology Data Exchange (ETDEWEB)

    Adams, C. [Yale Univ., New Haven, CT (United States); Alonso, J. R. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Ankowski, A. M. [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States); Asaadi, J. A. [Syracuse Univ., NY (United States); Ashenfelter, J. [Yale Univ., New Haven, CT (United States); Axani, S. N. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Babu, K [Oklahoma State Univ., Stillwater, OK (United States); Backhouse, C. [California Inst. of Technology (CalTech), Pasadena, CA (United States); Band, H. R. [Yale Univ., New Haven, CT (United States); Barbeau, P. S. [Duke Univ., Durham, NC (United States); Barros, N. [Univ. of Pennsylvania, Philadelphia, PA (United States); Bernstein, A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Betancourt, M. [Illinois Inst. of Technology, Chicago, IL (United States); Bishai, M. [Brookhaven National Lab. (BNL), Upton, NY (United States); Blucher, E. [Univ. of Chicago, IL (United States); Bouffard, J. [State Univ. of New York (SUNY), Albany, NY (United States); Bowden, N. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Brice, S. [Illinois Inst. of Technology, Chicago, IL (United States); Bryan, C. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Camilleri, L. [Columbia Univ., New York, NY (United States); Cao, J. [Inst. of High Energy Physics, Beijing (China); Carlson, J. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Carr, R. E. [Columbia Univ., New York, NY (United States); Chatterjee, A. [Univ. of Texas, Arlington, TX (United States); Chen, M. [Univ. of California, Irvine, CA (United States); Chen, S. [Tsinghua Univ., Beijing (China); Chiu, M. [Brookhaven National Lab. (BNL), Upton, NY (United States); Church, E. D. [Illinois Inst. of Technology, Chicago, IL (United States); Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Collar, J. I. [Univ. of Chicago, IL (United States); Collin, G. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Conrad, J. M. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Convery, M. R. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Cooper, R. L. [Indiana Univ., Bloomington, IN (United States); Cowen, D. [Pennsylvania State Univ., University Park, PA (United States); Davoudiasl, H. [Brookhaven National Lab. (BNL), Upton, NY (United States); Gouvea, A. D. [Northwestern Univ., Evanston, IL (United States); Dean, D. J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Deichert, G. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Descamps, F. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); DeYoung, T. [Michigan State Univ., East Lansing, MI (United States); Diwan, M. V. [Brookhaven National Lab. (BNL), Upton, NY (United States); Djurcic, Z. [Argonne National Lab. (ANL), Argonne, IL (United States); Dolinski, M. J. [Drexel Univ., Philadelphia, PA (United States); Dolph, J. [Brookhaven National Lab. (BNL), Upton, NY (United States); Donnelly, B. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Dwyer, D. A. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Dytman, S. [Univ. of Pittsburgh, PA (United States); Efremenko, Y. [Univ. of Tennessee, Knoxville, TN (United States); Everett, L. L. [Univ. of Wisconsin, Madison, WI (United States); Fava, A. [University of Padua, Padova (Italy); Figueroa-Feliciano, E. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Fleming, B. [Yale Univ., New Haven, CT (United States); Friedland, A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Fujikawa, B. K. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Gaisser, T. K. [Univ. of Delaware, Newark, DE (United States); Galeazzi, M. [Univ. of Miami, FL (United States); Galehouse, DC [Univ. of Akron, OH (United States); Galindo-Uribarri, A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Garvey, G. T. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Gautam, S. [Tribhuvan Univ., Kirtipur (Nepal); Gilje, K. E. [Illinois Inst. of Technology, Chicago, IL (United States); Gonzalez-Garcia, M. [Stony Brook Univ., NY (United States); Goodman, M. C. [Argonne National Lab. (ANL), Argonne, IL (United States); Gordon, H. [Brookhaven National Lab. (BNL), Upton, NY (United States); Gramellini, E. [Yale Univ., New Haven, CT (United States); Green, M. P. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Guglielmi, A. [University of Padua, Padova (Italy); Hackenburg, R. W. [Brookhaven National Lab. (BNL), Upton, NY (United States); Hackenburg, A. [Yale Univ., New Haven, CT (United States); Halzen, F. [Univ. of Wisconsin, Madison, WI (United States); Han, K. [Yale Univ., New Haven, CT (United States); Hans, S. [Brookhaven National Lab. (BNL), Upton, NY (United States); Harris, D. [Illinois Inst. of Technology, Chicago, IL (United States); Heeger, K. M. [Yale Univ., New Haven, CT (United States); Herman, M. [Brookhaven National Lab. (BNL), Upton, NY (United States); Hill, R. [Univ. of Chicago, IL (United States); Holin, A. [Univ. College London, Bloomsbury (United Kingdom); Huber, P. [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States); Jaffe, D. E. [Brookhaven National Lab. (BNL), Upton, NY (United States); Johnson, R. A. [Univ. of Cincinnati, OH (United States); Joshi, J. [Brookhaven National Lab. (BNL), Upton, NY (United States); Karagiorgi, G. [Univ. of Manchester (United Kingdom); Kaufman, L. J. [Indiana Univ., Bloomington, IN (United States); Kayser, B. [Illinois Inst. of Technology, Chicago, IL (United States); Kettell, S. H. [Brookhaven National Lab. (BNL), Upton, NY (United States); Kirby, B. J. [Brookhaven National Lab. (BNL), Upton, NY (United States); Klein, J. R. [Univ. of Texas, Arlington, TX (United States); Kolomensky, Y. G. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Univ. of California, Berkeley, CA (United States); Kriske, R. M. [Univ. of Minnesota, Minneapolis, MN (United States); Lane, C. E. [Drexel Univ., Philadelphia, PA (United States); Langford, T. J. [Yale Univ., New Haven, CT (United States); Lankford, A. [Univ. of California, Irvine, CA (United States); Lau, K. [Univ. of Houston, TX (United States); Learned, J. G. [Univ. of Hawaii, Honolulu, HI (United States); Ling, J. [Univ. of Illinois, Urbana-Champaign, IL (United States); Link, J. M. [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States); Lissauer, D. [Brookhaven National Lab. (BNL), Upton, NY (United States); Littenberg, L. [Brookhaven National Lab. (BNL), Upton, NY (United States); Littlejohn, B. R. [Illinois Inst. of Technology, Chicago, IL (United States); Lockwitz, S. [Illinois Inst. of Technology, Chicago, IL (United States); Lokajicek, M. [Inst. of Physics of the Academy of Sciences of Czech Republic, Prague (Czech Republic); Louis, W. C. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Luk, K. [Univ. of California, Berkeley, CA (United States); Lykken, J. [Illinois Inst. of Technology, Chicago, IL (United States); Marciano, W. J. [Brookhaven National Lab. (BNL), Upton, NY (United States); Maricic, J. [Univ. of Hawaii, Honolulu, HI (United States); Markoff, D. M. [North Carolina Central Univ., Durham, NC (United States); Caicedo, D. A. M. [Illinois Inst. of Technology, Chicago, IL (United States); Mauger, C. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Mavrokoridis, K. [Univ. of Liverpool (United Kingdom); McCluskey, E. [Illinois Inst. of Technology, Chicago, IL (United States); McKeen, D. [Univ. of Washington, Seattle, WA (United States); McKeown, R. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Mills, G. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Mocioiu, I. [Pennsylvania State Univ., University Park, PA (United States); Monreal, B. [Univ. of California, Santa Barbara, CA (United States); Mooney, M. R. [Brookhaven National Lab. (BNL), Upton, NY (United States); Morfin, J. G. [Illinois Inst. of Technology, Chicago, IL (United States); Mumm, P. [National Inst. of Standards and Technology (NIST), Boulder, CO (United States); Napolitano, J. [Temple Univ., Philadelphia, PA (United States); Neilson, R. [Drexel Univ., Philadelphia, PA (United States); Nelson, J. K. [College of William and Mary, Williamsburg, VA (United States); Nessi, M. [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Norcini, D. [Yale Univ., New Haven, CT (United States); Nova, F. [Univ. of Texas, Austin, TX (United States); Nygren, D. R. [Univ. of Texas, Arlington, TX (United States); Gann, GDO [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Univ. of California, Berkeley, CA (United States); Palamara, O. [Illinois Inst. of Technology, Chicago, IL (United States); Parsa, Z. [Brookhaven National Lab. (BNL), Upton, NY (United States); Patterson, R. [California Inst. of Technology (CalTech), Pasadena, CA (United States); Paul, P. [Stony Brook Univ., NY (United States); Pocar, A. [Univ. of Massachusetts, Amherst, MA (United States); Qian, X. [Brookhaven National Lab. (BNL), Upton, NY (United States); Raaf, J. L. [Illinois Inst. of Technology, Chicago, IL (United States); Rameika, R. [Illinois Inst. of Technology, Chicago, IL (United States); Ranucci, G. [National Inst. of Nuclear Physics, Milano (Italy); Ray, H. [Univ. of Florida, Gainesville, FL (United States); Reyna, D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Rich, G. C. [Triangle Universities Nuclear Lab., Durham, NC (United States); Rodrigues, P. [Univ. of Rochester, NY (United States); Romero, E. R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States); Rosero, R. [Brookhaven National Lab. (BNL), Upton, NY (United States); Rountree, S. D. [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States); Rybolt, B. [Univ. of Tennessee, Knoxville, TN (United States); Sanchez, M. C. [Iowa State Univ., Ames, IA (United States); Santucci, G. [Stony Brook Univ., NY (United States); Schmitz, D. [Univ. of Chicago, IL (United States); Scholberg, K. [Duke Univ., Durham, NC (United States); Seckel, D. [Univ. of Delaware, Newark, DE (United States); Shaevitz, M. [Columbia Univ., New York, NY (United States); Shrock, R. [Stony Brook Univ., NY (United States); Smy, M. B. [Univ. of California, Irvine, CA (United States); Soderberg, M. [Syracuse Univ., NY (United States); Sonzogni, A. [Brookhaven National Lab. (BNL), Upton, NY (United States); Sousa, A. B. [Univ. of Cincinnati, OH (United States); Spitz, J. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); John, J. M. S. [Univ. of Cincinnati, OH (United States); Stewart, J. [Brookhaven National Lab. (BNL), Upton, NY (United States); Strait, J. B. [Illinois Inst. of Technology, Chicago, IL (United States); Sullivan, G. [Univ. of Maryland, College Park, MD (United States); Svoboda, R. [Univ. of California, Davis, CA (United States); Szelc, A. M. [Yale Univ., New Haven, CT (United States); Tayloe, R. [Indiana Univ., Bloomington, IN (United States); Thomson, M. A. [Univ. of Cambridge (United Kingdom); Toups, M. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Vacheret, A. [Univ. of Oxford (United Kingdom); Vagins, M. [Univ. of California, Irvine, CA (United States); Water, R. G. V. D. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Vogelaar, R. B. [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States); Weber, M. [Bern (Switzerland); Weng, W. [Brookhaven National Lab. (BNL), Upton, NY (United States); Wetstein, M. [Univ. of Chicago, IL (United States); White, C. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); White, B. R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Whitehead, L. [Univ. of Houston, TX (United States); Whittington, D. W. [Indiana Univ., Bloomington, IN (United States); Wilking, M. J. [Stony Brook Univ., NY (United States); Wilson, R. J. [Colorado State Univ., Fort Collins, CO (United States); Wilson, P. [Illinois Inst. of Technology, Chicago, IL (United States); Winklehner, D. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Winn, D. R. [Fairfield Univ., CT (United States); Worcester, E. [Brookhaven National Lab. (BNL), Upton, NY (United States); Yang, L. [Univ. of Illinois, Urbana-Champaign, IL (United States); Yeh, M [Brookhaven National Lab. (BNL), Upton, NY (United States); Yokley, Z. W. [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States); Yoo, J. [Illinois Inst. of Technology, Chicago, IL (United States); Yu, B. [Brookhaven National Lab. (BNL), Upton, NY (United States); Yu, J. [Univ. of Texas, Arlington, TX (United States); Zhang, C. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2017-04-03

    The US neutrino community gathered at the Workshop on the Intermediate Neutrino Program (WINP) at Brookhaven National Laboratory February 4-6, 2015 to explore opportunities in neutrino physics over the next five to ten years. Scientists from particle, astroparticle and nuclear physics participated in the workshop. The workshop examined promising opportunities for neutrino physics in the intermediate term, including possible new small to mid-scale experiments, US contributions to large experiments, upgrades to existing experiments, R&D plans and theory. The workshop was organized into two sets of parallel working group sessions, divided by physics topics and technology. Physics working groups covered topics on Sterile Neutrinos, Neutrino Mixing, Neutrino Interactions, Neutrino Properties and Astrophysical Neutrinos. Technology sessions were organized into Theory, Short-Baseline Accelerator Neutrinos, Reactor Neutrinos, Detector R&D and Source, Cyclotron and Meson Decay at Rest sessions.This report summarizes discussion and conclusions from the workshop.

  6. Political polarization

    OpenAIRE

    Dixit, Avinash K.; Weibull, Jörgen W.

    2007-01-01

    Failures of government policies often provoke opposite reactions from citizens; some call for a reversal of the policy, whereas others favor its continuation in stronger form. We offer an explanation of such polarization, based on a natural bimodality of preferences in political and economic contexts and consistent with Bayesian rationality.

  7. Political polarization.

    Science.gov (United States)

    Dixit, Avinash K; Weibull, Jörgen W

    2007-05-01

    Failures of government policies often provoke opposite reactions from citizens; some call for a reversal of the policy, whereas others favor its continuation in stronger form. We offer an explanation of such polarization, based on a natural bimodality of preferences in political and economic contexts and consistent with Bayesian rationality.

  8. Intermediate energy data

    International Nuclear Information System (INIS)

    Koning, A.J.; Fukahori, T.; Hasegawa, A.

    1998-01-01

    Subgroup 13 (SG13) on Intermediate Energy Nuclear data was formed by NEA Nuclear Science Committee to solve common problems of these types of data for nuclear applications. An overview is presented in this final report of the present activities of SG13, including data needs, high-priority nuclear data request list (nuclides), compilation of experimental data, specialists meetings and benchmarks, data formats and data libraries. Some important accomplishments are summarized, and recommendations are presented. (R.P.)

  9. MHC-environment interactions leading to type 1 diabetes: feasibility of an analysis of HLA DR-DQ alleles in relation to manifestation periods and dates of birth.

    Science.gov (United States)

    Badenhoop, K; Kahles, H; Seidl, C; Kordonouri, O; Lopez, E R; Walter, M; Rosinger, S; Ziegler, A; Böhm, B O

    2009-02-01

    The region on chromosome 6p21 (IDDM1) confers the largest part of genetic susceptibility to type 1 diabetes (T1D) with particular human leucocyte antigen (HLA) alleles predisposing and others protecting from it. As T1D is primarily a "sporadic" disease, the pathophysiology must involve gene-environment interactions. We searched for indirect evidence for such major histocompatibility complex (MHC)-environment interactions by asking two questions: (i) can the degree of an HLA association vary over time periods? and (ii) if a prenatal event like an intrauterine infection - that might cluster in seasons - leads to differences of HLA associations in patients with particular birth months? We screened the Type 1 Diabetes Genetics Consortium (T1DGC) database (in addition our own database and the original UK, US and SCAND databases) for MHC DR-DQ and CTLA4 associations. First, we separated the groups of patients with onset of disease before 1980 in comparison with onset after 1980. Second, we analysed the data according to dates of birth (grouped in months). Not all patients' dates of birth or manifestation periods were available, leading to different group sizes. There were 282 patients analysed for manifestation periods and 329 for birth month. The cohorts of manifestation before 1980 demonstrated a significantly lower frequency of DQ2/X (2 vs. 14.2%; p = 0.03). There was a trend for DQ8/x to be more frequent for manifestations before 1980 (34 vs. 21.6%; p < 0.10). Other alleles did not differ significantly. The months of birth were not evenly distributed. Significant deviations from the whole group were seen in August (DQ2/8 trough and DQx/x high), whereas birth in September was more frequent in DQ8/x or DQ8/8 carriers. This pattern was significantly different from the expected distribution of months at birth (13.9 vs. 7.6%; p < 0.04). We demonstrate the feasibility of an analysis that searches for indirect evidence of gene-environment interactions. These preliminary

  10. Beta-cell, thyroid, gastric, adrenal and coeliac autoimmunity and HLA-DQ types in type 1 diabetes

    Science.gov (United States)

    De block, C E M; De leeuw, I H; Vertommen, J J F; Rooman, R P A; Du Caju, M V L; Van Campenhout, C M; Weyler, J J; Winnock, F; Van Autreve, J; Gorus, F K

    2001-01-01

    The autoimmune attack in type 1 diabetes is not only targeted to β cells. We assessed the prevalence of thyroid peroxidase (aTPO), parietal cell (PCA), antiadrenal (AAA) and endomysial antibodies (EmA-IgA), and of overt autoimmune disease in type 1 diabetes, in relation to gender, age, duration of disease, age at onset, β-cell antibody status (ICA, GADA, IA2A) and HLA-DQ type. Sera from 399 type 1 diabetic patients (M/F: 188/211; mean age: 26 ± 16 years; duration: 9 ± 8 years) were tested for ICA, PCA, AAA and EmA-IgA by indirect immunofluorescence, and for IA2A (tyrosine phosphatase antibodies), GADA (glutamic acid decarboxylase-65 antibodies) and aTPO by radiobinding assays. The prevalence rates were: GADA 70%; IA2A, 44%; ICA, 39%; aTPO, 22%; PCA, 18%; EmA-IgA, 2%; and AAA, 1%. aTPO status was determined by female gender (β = − 1·15, P = 0·002), age (β = 0·02, P = 0·01) and GADA + (β = 1·06, P = 0·02), but not by HLA-DQ type or IA2A status. Dysthyroidism (P < 0·0001) was more frequent in aTPO + subjects. PCA status was determined by age (β = 0·03, P = 0·002). We also observed an association between PCA + and GADA + (OR = 1·9, P = 0·049), aTPO + (OR = 1·9, P = 0·04) and HLA DQA1*0501-DQB1*0301 status (OR = 2·4, P = 0·045). Iron deficiency anaemia (OR = 3·0, P = 0·003) and pernicious anaemia (OR = 40, P < 0·0001) were more frequent in PCA + subjects. EmA-IgA + was linked to HLA DQA1*0501-DQB1*0201 + (OR = 7·5, P = 0·039), and coeliac disease was found in three patients. No patient had Addison's disease. In conclusion, GADA but not IA2A indicate the presence of thyrogastric autoimmunity in type 1 diabetes. aTPO have a female preponderance, PCA are weakly associated with HLA DQA1*0501-DQB1*0301 and EmA-IgA + with HLA DQA1*0501-DQB1*0201. PMID:11703366

  11. Complementary DNA sequences encoding the multimammate rat MHC class II DQ alpha and beta chains and cross-species sequence comparison in rodents.

    Science.gov (United States)

    de Bellocq, J Goüy; Leirs, H

    2009-09-01

    Sequences of the complete open reading frame (ORF) for rodents major histocompatibility complex (MHC) class II genes are rare. Multimammate rat (Mastomys natalensis) complementary DNA (cDNA) encoding the alpha and beta chains of MHC class II DQ gene was cloned from a rapid amplifications of cDNA Emds (RACE) cDNA library. The ORFs consist of 801 and 771 bp encoding 266 and 256 amino acid residues for DQB and DQA, respectively. The genomic structure of Mana-DQ genes is globally analogous to that described for other rodents except for the insertion of a serine residue in the signal peptide of Mana-DQB, which is unique among known rodents.

  12. Isolation and Characterization of Well-Defined Silica-Supported Azametallacyclopentane: A Key Intermediate in Catalytic Hydroaminoalkylation Reactions

    KAUST Repository

    Hamzaoui, Bilel

    2015-09-25

    Intermolecular catalytic hydroaminoalkylation of unactivated alkene occurs with silica-supported azazirconacyclopropane [[TRIPLE BOND]Si[BOND]O[BOND]Zr(HNMe2)(η2-NMeCH2)(NMe2)]. Mechanistic studies were conducted using surface organometallic chemistry (SOMC) concepts to identify the key surface intermediates. The azametallacyclopentene intermediate {[TRIPLE BOND]Si[BOND]O[BOND]Zr(HNMe2)[η2-NMeCH2CH(Me)CH2](NMe2)} was isolated after treating with 1-propylene and characterized by FT-IR spectroscopy, elemental analysis, 1H 13C HETCOR, DARR SS-NMR and DQ TQ SS-NMR. The regeneration of the catalyst was conducted by dimethylamine protonolysis to yield the pure amine.

  13. Complementary DNA sequences encoding the multimammate rat MHC class II DQ α and β chains and cross-species sequence comparison in rodents

    DEFF Research Database (Denmark)

    Goüy de Bellocq, J; Leirs, H

    2009-01-01

    DNA Emds (RACE) cDNA library. The ORFs consist of 801 and 771 bp encoding 266 and 256 amino acid residues for DQB and DQA, respectively. The genomic structure of Mana-DQ genes is globally analogous to that described for other rodents except for the insertion of a serine residue in the signal peptide...... of Mana-DQB, which is unique among known rodents....

  14. The HLA-DQ2 genotype selects for early intestinal microbiota composition in infants at high risk of developing coeliac disease.

    Science.gov (United States)

    Olivares, M; Neef, A; Castillejo, G; Palma, G De; Varea, V; Capilla, A; Palau, F; Nova, E; Marcos, A; Polanco, I; Ribes-Koninckx, C; Ortigosa, L; Izquierdo, L; Sanz, Y

    2015-03-01

    Intestinal dysbiosis has been associated with coeliac disease (CD), but whether the alterations are cause or consequence of the disease is unknown. This study investigated whether the human leukocyte antigen (HLA)-DQ2 genotype is an independent factor influencing the early gut microbiota composition of healthy infants at family risk of CD. As part of a larger prospective study, a subset (n=22) of exclusively breastfed and vaginally delivered infants with either high genetic risk (HLA-DQ2 carriers) or low genetic risk (non-HLA-DQ2/8 carriers) of developing CD were selected from a cohort of healthy infants with at least one first-degree relative with CD. Infant faecal microbiota was analysed by 16S rRNA gene pyrosequencing and real time quantitative PCR. Infants with a high genetic risk had significantly higher proportions of Firmicutes and Proteobacteria and lower proportions of Actinobacteria compared with low-risk infants. At genus level, high-risk infants had significantly less Bifidobacterium and unclassified Bifidobacteriaceae proportions and more Corynebacterium, Gemella, Clostridium sensu stricto, unclassified Clostridiaceae, unclassified Enterobacteriaceae and Raoultella proportions. Quantitative real time PCR also revealed lower numbers of Bifidobacterium species in infants with high genetic risk than in those with low genetic risk. In high-risk infants negative correlations were identified between Bifidobacterium species and several genera of Proteobacteria (Escherichia/Shigella) and Firmicutes (Clostridium). The genotype of infants at family risk of developing CD, carrying the HLA-DQ2 haplotypes, influences the early gut microbiota composition. This finding suggests that a specific disease-biased host genotype may also select for the first gut colonisers and could contribute to determining disease risk. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  15. Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk

    Science.gov (United States)

    Hu, Xinli; Deutsch, Aaron J; Lenz, Tobias L; Onengut-Gumuscu, Suna; Han, Buhm; Chen, Wei-Min; Howson, Joanna M M; Todd, John A; de Bakker, Paul I W; Rich, Stephen S; Raychaudhuri, Soumya

    2016-01-01

    Variation in the human leukocyte antigen (HLA) genes accounts for one-half of the genetic risk in type 1 diabetes (T1D). Amino acid changes in the HLA-DR and HLA-DQ molecules mediate most of the risk, but extensive linkage disequilibrium complicates the localization of independent effects. Using 18,832 case-control samples, we localized the signal to 3 amino acid positions in HLA-DQ and HLA-DR. HLA-DQβ1 position 57 (previously known; P = 1 × 10−1,355) by itself explained 15.2% of the total phenotypic variance. Independent effects at HLA-DRβ1 positions 13 (P = 1 × 10−721) and 71 (P = 1 × 10−95) increased the proportion of variance explained to 26.9%. The three positions together explained 90% of the phenotypic variance in the HLA-DRB1–HLA-DQA1–HLA-DQB1 locus. Additionally, we observed significant interactions for 11 of 21 pairs of common HLA-DRB1–HLA-DQA1–HLA-DQB1 haplotypes (P = 1.6 × 10−64). HLA-DRβ1 positions 13 and 71 implicate the P4 pocket in the antigen-binding groove, thus pointing to another critical protein structure for T1D risk, in addition to the HLA-DQ P9 pocket. PMID:26168013

  16. [Analysis of the association of human leukocyte antigen DQ gene polymorphisms with unexplained recurrent spontaneous abortion among ethnic Han Chinese from Wenzhou region].

    Science.gov (United States)

    Zheng, Jiayong; Zhang, Hongping; Xu, Xiaomin; Ma, Weide; Li, Jianxin; Xia, Shuqi; Wang, Hai; Shen, Xiaolu

    2016-02-01

    To assess the association of human leukocyte antigen DQ gene polymorphisms with unexplained recurrent spontaneous abortion (URSA) among ethnic Han Chinese from Wenzhou region. Fifty couples with URSA (URSA group) and 66 couples with normal pregnancy history (control group) were recruited. The alleles of HLA-DQA1 and HLA-DQB1 were analyzed by polymerase chain reaction with specific sequence primers (PCR-SSP) in all subjects. The frequency distribution of HLA-DQ alleles, odds ratios (OR) between each group and sharing of HLA-DQ alleles were calculated. The frequency distribution of HLA-DQB1*03:03 allele in the females with URSA was significantly higher than that healthy females (21.00% vs. 9.85%, OR=2.433, 95%CI: 1.232-4.894, χ(2)=5.657, PHLA-DQA1 alleles in couples with URSA was increased compared with the control group (70.27% vs. 44.64%, OR=2.931, 95%CI: 1.216-7.067, PHLA-DQA1 alleles may contribute to the susceptibility of URSA among ethnic Han Chinese from Wenzhou region. The allele of HLA-DQB1*03:03 in the females may be predisposing factor for URSA. However, the HLA-DQB1*05:02 allele in both gender and HLA-DQB1*05:03 allele in females may confer a protective effect.

  17. Role of the Group 2 Mrp sodium/proton antiporter in rapid response to high alkaline shock in the alkaline- and salt-tolerant Dietzia sp. DQ12-45-1b.

    Science.gov (United States)

    Fang, Hui; Qin, Xiao-Yu; Zhang, Kai-Duan; Nie, Yong; Wu, Xiao-Lei

    2018-04-01

    The six- and seven-subunit Na + /H + antiporters (Mrp) are widely distributed in bacteria. They are reported to be integral for pH homeostasis in alkaliphilic bacteria when adapting to high pH environments. In this study, operons encoding for the six-subunit Na + /H + antiporters were found in the genomes of all studied Dietzia strains, which have different alkaline-resistant abilities. Disruption of the operon in the strain Dietzia sp. DQ12-45-1b which leads to declined growth in presence of hypersaline and alkaline conditions suggested that the six-subunit Na + /H + antiporter played an important role in hypersaline and alkaline resistance. Although the complexes DqMrp from DQ12-45-1b (strain with high alkaline resistance) and DaMrp from D. alimentaria 72 T (strain with low alkaline resistance) displayed Na + (Li + )/H + antiport activities, they functioned optimally at different pH levels (9.0 for DQ12-45-1b and 8.0 for 72 T ). While both antiporters functioned properly to protect Escherichia coli cells from salt shock, only the DqMrp-containing strain survived the high alkaline shock. Furthermore, real-time PCR results showed that the expression of mrpA and mrpD induced only immediately after DQ12-45-1b cells were subjected to the alkaline shock. These results suggested that the expression of DqMrp might be induced by a pH gradient across the cell membrane, and DqMrp mainly functioned at an early stage to respond to the alkaline shock.

  18. Intermediate Temperature Solid Oxide Fuel Cell Development

    Energy Technology Data Exchange (ETDEWEB)

    S. Elangovan; Scott Barnett; Sossina Haile

    2008-06-30

    Solid oxide fuel cells (SOFCs) are high efficiency energy conversion devices. Present materials set, using yttria stabilized zirconia (YSZ) electrolyte, limit the cell operating temperatures to 800 C or higher. It has become increasingly evident however that lowering the operating temperature would provide a more expeditious route to commercialization. The advantages of intermediate temperature (600 to 800 C) operation are related to both economic and materials issues. Lower operating temperature allows the use of low cost materials for the balance of plant and limits degradation arising from materials interactions. When the SOFC operating temperature is in the range of 600 to 700 C, it is also possible to partially reform hydrocarbon fuels within the stack providing additional system cost savings by reducing the air preheat heat-exchanger and blower size. The promise of Sr and Mg doped lanthanum gallate (LSGM) electrolyte materials, based on their high ionic conductivity and oxygen transference number at the intermediate temperature is well recognized. The focus of the present project was two-fold: (a) Identify a cell fabrication technique to achieve the benefits of lanthanum gallate material, and (b) Investigate alternative cathode materials that demonstrate low cathode polarization losses at the intermediate temperature. A porous matrix supported, thin film cell configuration was fabricated. The electrode material precursor was infiltrated into the porous matrix and the counter electrode was screen printed. Both anode and cathode infiltration produced high performance cells. Comparison of the two approaches showed that an infiltrated cathode cells may have advantages in high fuel utilization operations. Two new cathode materials were evaluated. Northwestern University investigated LSGM-ceria composite cathode while Caltech evaluated Ba-Sr-Co-Fe (BSCF) based pervoskite cathode. Both cathode materials showed lower polarization losses at temperatures as low as 600

  19. Bacterial intermediate filaments

    DEFF Research Database (Denmark)

    Charbon, Godefroid; Cabeen, M.; Jacobs-Wagner, C.

    2009-01-01

    Crescentin, which is the founding member of a rapidly growing family of bacterial cytoskeletal proteins, was previously proposed to resemble eukaryotic intermediate filament (IF) proteins based on structural prediction and in vitro polymerization properties. Here, we demonstrate that crescentin...... also shares in vivo properties of assembly and dynamics with IF proteins by forming stable filamentous structures that continuously incorporate subunits along their length and that grow in a nonpolar fashion. De novo assembly of crescentin is biphasic and involves a cell size-dependent mechanism...... a new function for MreB and providing a parallel to the role of actin in IF assembly and organization in metazoan cells. Additionally, analysis of an MreB localization mutant suggests that cell wall insertion during cell elongation normally occurs along two helices of opposite handedness, each...

  20. Strategic Polarization.

    Science.gov (United States)

    Kalai, Adam; Kalai, Ehud

    2001-08-01

    In joint decision making, similarly minded people may take opposite positions. Consider the example of a marriage in which one spouse gives generously to charity while the other donates nothing. Such "polarization" may misrepresent what is, in actuality, a small discrepancy in preferences. It may be that the donating spouse would like to see 10% of their combined income go to charity each year, while the apparently frugal spouse would like to see 8% donated. A simple game-theoretic analysis suggests that the spouses will end up donating 10% and 0%, respectively. By generalizing this argument to a larger class of games, we provide strategic justification for polarization in many situations such as debates, shared living accommodations, and disciplining children. In some of these examples, an arbitrarily small disagreement in preferences leads to an arbitrarily large loss in utility for all participants. Such small disagreements may also destabilize what, from game-theoretic point of view, is a very stable equilibrium. Copyright 2001 Academic Press.

  1. Analysis and Design of a Maglev Permanent Magnet Synchronous Linear Motor to Reduce Additional Torque in dq Current Control

    Directory of Open Access Journals (Sweden)

    Feng Xing

    2018-03-01

    Full Text Available The maglev linear motor has three degrees of motion freedom, which are respectively realized by the thrust force in the x-axis, the levitation force in the z-axis and the torque around the y-axis. Both the thrust force and levitation force can be seen as the sum of the forces on the three windings. The resultant thrust force and resultant levitation force are independently controlled by d-axis current and q-axis current respectively. Thus, the commonly used dq transformation control strategy is suitable for realizing the control of the resultant force, either thrust force and levitation force. However, the forces on the three windings also generate additional torque because they do not pass the mover mass center. To realize the maglev system high-precision control, a maglev linear motor with a new structure is proposed in this paper to decrease this torque. First, the electromagnetic model of the motor can be deduced through the Lorenz force formula. Second, the analytic method and finite element method are used to explore the reason of this additional torque and what factors affect its change trend. Furthermore, a maglev linear motor with a new structure is proposed, with two sets of 90 degrees shifted winding designed on the mover. Under such a structure, the mover position dependent periodic part of the additional torque can be offset. Finally, the theoretical analysis is validated by the simulation result that the additionally generated rotating torque can be offset with little fluctuation in the proposed new-structure maglev linear motor. Moreover, the control system is built in MATLAB/Simulink, which shows that it has small thrust ripple and high-precision performance.

  2. HLA-DP, HLA-DQ, and HLA-DR-restricted epitopes in GRA5 of toxoplasma gondii strains

    Science.gov (United States)

    Haryati, S.; Sari, Y.; Prasetyo, A. A.; Sariyatun, R.

    2016-01-01

    The dense granular (GRA) proteins of Toxoplasma gondii(T. gondii) have been demonstrated as potential sources of T. gondii vaccine antigens. However, data of the GRA5 protein are limited. This study analyzed twenty-one complete GRA5 sequences of T. gondii GT1, RH, ME49, VEG, MAS, RUB, FOU, p89, VAND, and GAB2-2007-GAL-DOM2 strains to identify potential epitopes restricted by Major Histocompatibility Complex class II (MHC- II) molecules (human leukocyte antigen (HLA)-DP, HLA-DQ, and HLA-DR) in the protein. In all T. gondii strains, peptides positioned at amino acid (aa) 15-29, 16-30, 17-31, 18-32, 19-33, 83-97, 84-98, 86-100, 87-101, 89-103, and 90-104 were predicted to pose high affinity and binding with HLA-DRB1*0101, HLA-DRB1*0301 (DR17), HLA-DRB1*0401 (DR4Dw4), HLA-DRB1*0701, HLA-DRB1*1101, HLA-DRB1*1501 (DR2b), and/or HLA-DRB5*0101. Considering the epitope's affinity, ligation strength, and hydrophilicity, LRLLRRRRRRAIQEE sequence (aa 90-104) restricted by HLA-DRB1*0101, HlA- DRB1*0301 (DR17), and HLA-DRB1*0401 (DR4Dw4) was considered as the most potential MHC-II epitope in GRA5 of T. gondii. These results would be useful for studies concerning in developing T. gondii vaccine and diagnostic method.

  3. AODV Routing Protocol Modification With Dqueue(dqAODV and Optimization With Neural Network For VANET In City Scenario

    Directory of Open Access Journals (Sweden)

    Saha Soumen

    2016-01-01

    Full Text Available Vehicular ad hoc network (VANET is considered as a sub-set of mobile ad hoc network (MANET. VANET can provide road safety by generating collision warning messages before a collision takes place, lane change assistance; can provide efficient traffic system by introducing cooperation among vehicles; and can also improves in infotainment applications like cooperative file accessing, accessing internet, viewing movies etc. It provides smart Transportation System i.e., wireless ad-hoc communication among vehicles and vehicle to roadside equipments. VANET communication broadly distinguished in two types; 1 vehicle to vehicle interaction, 2 vehicle to infrastructure interaction. The main objective of VANET is to provide safe, secure and automated traffic system. For this automated traffic techniques, there are several types of routing protocols has been developed. MANET routing protocols are not equally applicable in VANET. In the recent past Roy and his group has proposed several study in VANET transmission in [1-3]. In this study, we propose a modified AODV routing protocol in the context of VANET with the help of dqueue introduction into the RREQ header. Recently Saha et al [4] has reported the results showing the nature of modified AODV obtained from the rudimentary version of their simulation code. It is mainly based on packet delivery throughput. It shows greater in-throughput information of packet transmission compare to original AODV. Hence our proposal has less overhead and greater performance routing algorithm compared to conventional AODV. In this study, we propose and implement in the NCTUns-6.0 simulator, the neural network based modified dqueue AODV (dqAODV routing protocol considering Power, TTL, Node distance and Payload parameter to find the optimal route from the source station (vehicle to the destination station in VANET communications. The detail simulation techniques with result and output will be presented in the conference.

  4. Photometric variability in a warm, strongly magnetic DQ white dwarf, SDSS J103655.39+652252.2

    International Nuclear Information System (INIS)

    Williams, Kurtis A.; Winget, D. E.; Montgomery, M. H.; Hermes, J. J.; Falcon, Ross E.; Winget, K. I.; Dufour, Patrick; Kepler, S. O.; Bolte, Michael; Rubin, Kate H. R.; Liebert, James

    2013-01-01

    We present the discovery of photometric variability in the DQ white dwarf SDSS J103655.39+652252.2 (SDSS J1036+6522). Time-series photometry reveals a coherent monoperiodic modulation at a period of 1115.64751(67) s with an amplitude 0.442% ± 0.024%; no other periodic modulations are observed with amplitudes ≳ 0.13%. The period, amplitude, and phase of this modulation are constant within errors over 16 months. The spectrum of SDSS J1036+6522 shows magnetic splitting of carbon lines, and we use Paschen-Back formalism to develop a grid of model atmospheres for mixed carbon and helium atmospheres. Our models, while reliant on several simplistic assumptions, nevertheless match the major spectral and photometric properties of the star with a self-consistent set of parameters: T eff ≈ 15, 500 K, log g ≈ 9, log (C/He) = –1.0, and a mean magnetic field strength of 3.0 ± 0.2 MG. The temperature and abundances strongly suggest that SDSS J1036+6522 is a transition object between the hot, carbon-dominated DQs and the cool, helium-dominated DQs. The variability of SDSS J1036+6522 has characteristics similar to those of the variable hot carbon-atmosphere white dwarfs (DQVs), however, its temperature is significantly cooler. The pulse profile of SDSS J1036+6522 is nearly sinusoidal, in contrast with the significantly asymmetric pulse shapes of the known magnetic DQVs. If the variability in SDSS J1036+6522 is due to the same mechanism as other DQVs, then the pulse shape is not a definitive diagnostic on the absence of a strong magnetic field in DQVs. It remains unclear whether the root cause of the variability in SDSS J1036+6522 and the other hot DQVs is the same.

  5. Information acquisition and financial intermediation

    OpenAIRE

    Boyarchenko, Nina

    2012-01-01

    This paper considers the problem of information acquisition in an intermediated market, where the specialists have access to superior technology for acquiring information. These informational advantages of specialists relative to households lead to disagreement between the two groups, changing the shape of the intermediation-constrained region of the economy and increasing the frequency of periods when the intermediation constraint binds. Acquiring the additional information is, however, cost...

  6. Intermediate inputs and economic productivity.

    Science.gov (United States)

    Baptist, Simon; Hepburn, Cameron

    2013-03-13

    Many models of economic growth exclude materials, energy and other intermediate inputs from the production function. Growing environmental pressures and resource prices suggest that this may be increasingly inappropriate. This paper explores the relationship between intermediate input intensity, productivity and national accounts using a panel dataset of manufacturing subsectors in the USA over 47 years. The first contribution is to identify sectoral production functions that incorporate intermediate inputs, while allowing for heterogeneity in both technology and productivity. The second contribution is that the paper finds a negative correlation between intermediate input intensity and total factor productivity (TFP)--sectors that are less intensive in their use of intermediate inputs have higher productivity. This finding is replicated at the firm level. We propose tentative hypotheses to explain this association, but testing and further disaggregation of intermediate inputs is left for further work. Further work could also explore more directly the relationship between material inputs and economic growth--given the high proportion of materials in intermediate inputs, the results in this paper are suggestive of further work on material efficiency. Depending upon the nature of the mechanism linking a reduction in intermediate input intensity to an increase in TFP, the implications could be significant. A third contribution is to suggest that an empirical bias in productivity, as measured in national accounts, may arise due to the exclusion of intermediate inputs. Current conventions of measuring productivity in national accounts may overstate the productivity of resource-intensive sectors relative to other sectors.

  7. Assessment of CD4+ T cell responses to glutamic acid decarboxylase 65 using DQ8 tetramers reveals a pathogenic role of GAD65 121-140 and GAD65 250-266 in T1D development.

    Directory of Open Access Journals (Sweden)

    I-Ting Chow

    Full Text Available Susceptibility to type 1 diabetes (T1D is strongly associated with MHC class II molecules, particularly HLA-DQ8 (DQ8: DQA1*03:01/DQB1*03:02. Monitoring T1D-specific T cell responses to DQ8-restricted epitopes may be key to understanding the immunopathology of the disease. In this study, we examined DQ8-restricted T cell responses to glutamic acid decarboxylase 65 (GAD65 using DQ8 tetramers. We demonstrated that GAD65 121-140 and GAD65 250-266 elicited responses from DQ8+ subjects. Circulating CD4+ T cells specific for these epitopes were detected significantly more often in T1D patients than in healthy individuals after in vitro expansion. T cell clones specific for GAD65 121-140 and GAD65 250-266 carried a Th1-dominant phenotype, with some of the GAD65 121-140-specific T cell clones producing IL-17. GAD65 250-266-specific CD4+ T cells could also be detected by direct ex vivo staining. Analysis of unmanipulated peripheral blood mononuclear cells (PBMCs revealed that GAD65 250-266-specific T cells could be found in both healthy and diabetic individuals but the frequencies of specific T cells were higher in subjects with type 1 diabetes. Taken together, our results suggest a proinflammatory role for T cells specific for DQ8-restricted GAD65 121-140 and GAD65 250-266 epitopes and implicate their possible contribution to the progression of T1D.

  8. Precessing deuteron polarization

    International Nuclear Information System (INIS)

    Sitnik, I.M.; Volkov, V.I.; Kirillov, D.A.; Piskunov, N.M.; Plis, Yu.A.

    2002-01-01

    The feasibility of the acceleration in the Nuclotron of deuterons polarized in the horizontal plane is considered. This horizontal polarization is named precessing polarization. The effects of the main magnetic field and synchrotron oscillations are included. The precessing polarization is supposed to be used in studying the polarization parameters of the elastic dp back-scattering and other experiments

  9. Welding. Performance Objectives. Intermediate Course.

    Science.gov (United States)

    Vincent, Kenneth

    Several intermediate performance objectives and corresponding criterion measures are listed for each of nine terminal objectives for an intermediate welding course. The materials were developed for a 36-week (3 hours daily) course designed to prepare the student for employment in the field of welding. Electric welding and specialized (TIG & MIG)…

  10. Polare maskuliniteter

    Directory of Open Access Journals (Sweden)

    Marit Anne Hauan

    2012-05-01

    Full Text Available In this paper my aim is to read and understand the journal of Gerrit de Veer from the last journey of William Barents to the Arctic Regions in 1596 and the journal of captain Junge on his hunting trip from Tromsø to Svalbard in 1834.It is nearly 240 years between this to voyages. The first journal is known as the earliest report from the arctic era. Gerrit de Veer adds instructive copper engravings to his text and give us insight in the crews meeting with this new land. Captain Junges journal is found together with his dead crew in a house in a fjord nearby Ny-Ålesund and has no drawings, but word. Both of these journals may be read as sources of the knowledge and understanding of the polar region. They might also unveil the ideas of how to deal with and survive under the challenges that is given. In addition one can ask if the sources can tell us more about how men describe their challenges. Can the way they expressed themselves in the journals give us an understanding of masculinity? And not least help us to create good questions of the change in the ideas of masculinities which is said to follow the change in understanding of the wilderness.

  11. Investigating the Deflagration to Detonation Transition in LLM-105 and RX-55-DQ Using High Confinement as a Function of Density

    Science.gov (United States)

    Strickland, Shawn L.; Vandersall, Kevin S.; Dehaven, Martin R.

    2017-06-01

    The potential for deflagration-to-detonation transition (DDT) in LLM-105 and RX-55-DQ (94/6 LLM-105/Viton) has been investigated as a function of loading density using high confinement tubes. The high confinement arrangement uses a 76 mm outer diameter by 25 mm inner diameter mild steel tube 320 mm in length with 25 mm thick mild steel end caps ignited using a thermite igniter and was loaded with samples of varying densities. None of the experiments showed a transition to detonation over the entire length with non-violent burning or extinguishing of the burning observed. The hand packed RX-55-DQ molding powder or neat LLM-105 ( 1.1 g/cm3) burned nearly completely and vented non-violently by deforming or splitting the end caps. The RX-55-DQ was tested at higher densities with 1.35 g/cm3 resulting in a burning reaction on the 2nd attempt that fractured the end cap while the 1.85 g/cm3 resulted in the burning reaction extinguishing in the first 15 mm on the 2nd attempt. This work will outline the testing details, present the results, and compare them to the relatively high binder content HMX-based LX-04 (85% HMX and 15% Viton) and ultra-fine TATB results tested under similar confinement. This work performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

  12. Polymorphisms in HLA-DQ genes, together with age, sex, and Helicobacter pylori infection, as potential biomarkers for the early diagnosis of gastric cancer.

    Science.gov (United States)

    Pérez-Rodríguez, Martha; Partida-Rodríguez, Oswaldo; Camorlinga-Ponce, Margarita; Flores-Luna, Lourdes; Lazcano, Eduardo; Gómez, Alejandro; Herrera-Goepfert, Roberto; Medrano-Guzmán, Rafael; Torres, Javier

    2017-02-01

    Polymorphisms in inflammation-related genes are factors associated with the development of gastroduodenal diseases in Helicobacter pylori-infected individuals. We aimed to analyze polymorphisms in HLA-DQ, together with other host and H. pylori variables as risk factors for precancerous and cancerous gastric lesions. 1052 individuals were studied, including nonatrophic gastritis (NAG), intestinal metaplasia (IM), gastric cancer (GC) or duodenal ulcer (DU) patients, and healthy volunteers. Patients with alleles DQA*01:01 (OR 0.78), *01:02 (OR 0.29), *01:03 (OR 0.31), and DQB*02:01/02 (OR 0.40) showed a reduced risk for GC. A multivariate logistic regression analyses showed that patients with homozygote genotypes DQA1*03:01 (OR 7.27) and DQA1*04:01 (OR 8.99) and DQB1*05:01:01 (OR 12.04) were at significantly increased risk for GC. Multivariate analyses also demonstrated that age (OR>10.0) and gender (OR>2.0) were variables that influenced significantly the risk for GC, while H. pylori infection (OR>2.5) increased the risk for IM. We identified HLA-DQ alleles associated with IM and GC, and confirm that age, sex, and H. pylori infection are variables that also influence the risk for disease. The use of multiple markers, HLA-DQ alleles, age, sex, and H. pylori infection may be useful biomarkers for the early diagnosis of patients with IM and GC. © 2016 John Wiley & Sons Ltd.

  13. HLA-DQ:gluten tetramer test in blood gives better detection of coeliac patients than biopsy after 14-day gluten challenge.

    Science.gov (United States)

    Sarna, Vikas K; Skodje, Gry I; Reims, Henrik M; Risnes, Louise F; Dahal-Koirala, Shiva; Sollid, Ludvig M; Lundin, Knut E A

    2017-08-04

    Initiation of a gluten-free diet without proper diagnostic work-up of coeliac disease is a frequent and demanding problem. Recent diagnostic guidelines suggest a gluten challenge of at least 14 days followed by duodenal biopsy in such patients. The rate of false-negative outcome of this approach remains unclear. We studied responses to 14-day gluten challenge in subjects with treated coeliac disease. We challenged 20 subjects with biopsy-verified coeliac disease, all in confirmed mucosal remission, for 14 days with 5.7 grams per oral gluten daily. Duodenal biopsies were collected. Blood was analysed by multiplex assay for cytokine detection, and by flow cytometry using HLA-DQ:gluten tetramers. Nineteen participants completed the challenge. Villous blunting appeared at end of challenge in 5 of 19 subjects. Villous height to crypt depth ratio reduced with at least 0.4 concomitantly with an increase in intraepithelial lymphocyte count of at least 50% in 9 of 19 subjects. Interleukin-8 plasma concentration increased by more than 100% after 4 hours in 7 of 19 subjects. Frequency of blood CD4 + effector-memory gut-homing HLA-DQ:gluten tetramer-binding T cells increased by more than 100% on day 6 in 12 of 15 evaluated participants. A 14-day gluten challenge was not enough to establish significant mucosal architectural changes in majority of patients with coeliac disease (sensitivity ≈25%-50%). Increase in CD4 + effector-memory gut-homing HLA-DQ:gluten tetramer-binding T cells in blood 6 days after gluten challenge is a more sensitive and less invasive biomarker that should be validated in a larger study. NCT02464150. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  14. Association of human leukocyte antigen (HLA)-DQ and HLA-DQA1/DQB1 alleles with Vogt-Koyanagi-Harada disease: A systematic review and meta-analysis.

    Science.gov (United States)

    Liu, Bing; Deng, Tuo; Zhu, Linxin; Zhong, Jingxiang

    2018-02-01

    The aim of this study was to evaluate the association of human leukocyte antigen (HLA)-DQ and HLA-DQA1/DQB1 alleles with Vogt-Koyanagi-Harada (VKH), providing further evidences on the genetic background of this disease. A comprehensive literature search was conducted on the relationship of HLA-DQ and/or HLA-DQA1/DQB1 alleles with VKH through PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, VIP, and databases for grey literature. The last search was in October 2017. Pooled odds ratio (OR) with 95% confidence interval (95% CI) was calculated from extracted data to access the strength of the association between a genotype and VKH. HLA-DQ4 was confirmed to increase the risk of VKH significantly (OR = 4.63, 95% CI: 1.74-12.31, P = .002), while HLA-DQ1 seemed to reduce VKH occurrence with OR = 0.32 (95% CI: 0.22-0.47, P HLA-DQA1*0301-(OR = 4.52, 95% CI: 1.42-14.35, P = .01) and HLA-DQB1*0401-(OR = 23.12, 95% CI: 11.54-46.31, P HLA-DQA1*0103, 0401, 0501 and HLA-DQB1*0301, 0402, 0601, 0603 were significant protective genetic factors. We concluded that HLA-DQ4 carriers had a higher risk of VKH and HLA-DQ1 seemed to be protective. People with positive HLA-DQA1*0301 and HLA-DQB1*0401 demonstrated to be more susceptible to VKH. HLA-DQA1*0103, 0401, 0501 and HLA-DQB1*0301, 0402, 0601, 0603 could be potential protectors.

  15. PIWIL1/piRNA-DQ593109 Regulates the Permeability of the Blood-Tumor Barrier via the MEG3/miR-330-5p/RUNX3 Axis

    Directory of Open Access Journals (Sweden)

    Shuyuan Shen

    2018-03-01

    Full Text Available The blood-tumor barrier (BTB restricts the efficient delivery of anti-glioma drugs to cranial glioma tissues. Increased BTB permeability may allow greater delivery of the therapeutic agents. Increasing evidence has revealed that PIWI proteins and PIWI-interacting RNAs (piRNAs play an important role in tumor progression. However, whether PIWI proteins and piRNAs regulate BTB permeability remains unclear. In the present study, we demonstrated that the PIWIL1/piRNA-DQ593109 (piR-DQ593109 complex was the predominant regulator of BTB permeability. Briefly, PIWIL1 was upregulated in glioma endothelial cells (GECs. Furthermore, piR-DQ593109 was also overexpressed in GECs, as revealed via a piRNA microarray. Downregulation of PIWIL1 or piR-DQ593109 increased the permeability of the BTB. Moreover, PIWIL1 and piR-DQ593109, which formed a piRNA-induced silencing complex, degraded the long non-coding RNA maternally expressed 3 (MEG3 in a sequenced-dependent manner. Furthermore, restoring MEG3 released post-transcriptional inhibition of Runt related transcription factor 3 (RUNX3 by sponging miR-330-5p. In addition, RUNX3 bounded to the promoter regions and reduced the promoter activities of ZO-1, occludin, and claudin-5, which significantly impaired the expression levels of ZO-1, occludin, and claudin-5. In conclusion, downregulating PIWIL1 and piR-DQ593109 increased BTB permeability through the MEG3/miR-330-5p/RUNX3 axis. These data may provide insight into glioma treatment.

  16. Polarized electron sources

    Energy Technology Data Exchange (ETDEWEB)

    Prepost, R. [Univ. of Wisconsin, Madison, WI (United States)

    1994-12-01

    The fundamentals of polarized electron sources are described with particular application to the Stanford Linear Accelerator Center. The SLAC polarized electron source is based on the principle of polarized photoemission from Gallium Arsenide. Recent developments using epitaxially grown, strained Gallium Arsenide cathodes have made it possible to obtain electron polarization significantly in excess of the conventional 50% polarization limit. The basic principles for Gallium and Arsenide polarized photoemitters are reviewed, and the extension of the basic technique to strained cathode structures is described. Results from laboratory measurements of strained photocathodes as well as operational results from the SLAC polarized source are presented.

  17. HLA-DRB and HLA-DQ genetic variability in patients with aspirin-exacerbated respiratory disease.

    Science.gov (United States)

    Esmaeilzadeh, Hossein; Nabavi, Mohammad; Amirzargar, Ali Akbar; Aryan, Zahra; Arshi, Saba; Bemanian, Mohammad Hassan; Fallahpour, Morteza; Mortazavi, Negar; Rezaei, Nima

    2015-01-01

    Major histocompatibility complex (MHC) class II is involved in T-cell activation, cytokine secretion, and induction of immune responses. Cytokines, staphylococcus super antigens, and eosinophil activation are proposed to play important roles in aspirin-exacerbated respiratory disease (AERD). This study is aimed at investigating the association of HLA-DRB and DQ genetic variabilities in patients with AERD. A genetic association analysis in three different groups, including 33 patients with AERD, 17 patients with aspirin-tolerant asthma (ATA), and 100 healthy controls was performed. Oral aspirin challenge (OAC) test was performed to identify aspirin hypersensitivity. Pulmonary function test (PFT) was performed for all patients. Eosinophil percentage in nasal smear and peripheral blood and serum immunoglobin (Ig)E were investigated. HLA-DRB, HLA-DQA1, and HLA-DQB1 were genotyped using polymerase chain reaction. HLA-DQB1*0302 (OR, 5.49, 95% confidence interval [CI],(2.40-12.59)), HLA-DQA1*0301 (OR, 2.90, 95% CI, (1.49-5.67)), HLA-DRB4 (OR, 2.94, 95% CI, (1.61-5.36)), and HLA-DRB1*04 (OR, 3.19, 95% CI, (1.57-6.47)) were higher in patients with AERD compared with controls. In patients with AERD, HLA-DQB1*0301 (OR,0.22, 95% CI, (0.09-0.54)), HLA-DQA1*0501 (OR, 0.42, 95% CI, (0.21-0.81)), HLA-DRB1*11 (OR, 0.30, 95% CI, (0.12-0.73)), and HLA-DRB3 (OR, 0.38, 95% CI, (0.21-0.70)) were significantly lower compared with healthy controls. Patients with AERD had lower frequencies of HLA-DQB1*0301 (OR, 0.27, 95% CI, (0.08-0.86)), and HLA-DRB1*011 (OR, 0.27, 95% CI, (0.08-0.86)) compared with ATA. Haplotypes of HLA-DRB1*04/ DQA1*0301/ DQB1*0302 (OR, 4.25, 95% CI, (1.94-9.29)) and HLA-DRB1*07 /DQA1*0201/ DQB1*0201 (OR, 3.52, 95% CI, (1.54-8.06)) were higher in patients with AERD compared with controls (all p < 0.05). Results of this study suggest that HLA-DQB1*0302 and HLA-DRB1*04 and their related haplotypes are genes involved in predisposing patients to AERD, whereas HLA-DQB1

  18. Gravity with Intermediate Goods Trade

    Directory of Open Access Journals (Sweden)

    Sujin Jang

    2017-12-01

    Full Text Available This paper derives the gravity equation with intermediate goods trade. We extend a standard monopolistic competition model to incorporate intermediate goods trade, and show that the gravity equation with intermediates trade is identical to the one without it except in that gross output should be used as the output measure instead of value added. We also show that the output elasticity of trade is significantly underestimated when value added is used as the output measure. This implies that with the conventional gravity equation, the contribution of output growth can be substantially underestimated and the role of trade costs reduction can be exaggerated in explaining trade expansion, as we demonstrate for the case of Korea's trade growth between 1995 and 2007.

  19. Larval helminths in intermediate hosts

    DEFF Research Database (Denmark)

    Fredensborg, Brian Lund; Poulin, R

    2005-01-01

    Density-dependent effects on parasite fitness have been documented from adult helminths in their definitive hosts. There have, however, been no studies on the cost of sharing an intermediate host with other parasites in terms of reduced adult parasite fecundity. Even if larval parasites suffer...... transmission to their bird definitive host by predation. In experimental infections, we found an intensity-dependent establishment success, with a decrease in the success rate of cercariae developing into infective metacercariae with an increasing dose of cercariae applied to each amphipod. In natural...... the two species. Our results thus indicate that the infracommunity of larval helminths in their intermediate host is interactive and that any density-dependent effect in the intermediate host may have lasting effects on individual parasite fitness....

  20. Geographical Income Polarization

    DEFF Research Database (Denmark)

    Azhar, Hussain; Jonassen, Anders Bruun

    inter municipal income inequality. Counter factual simulations show that rising property prices to a large part explain the rise in polarization. One side-effect of polarization is tendencies towards a parallel polarization of residence location patterns, where low skilled individuals tend to live......In this paper we estimate the degree, composition and development of geographical income polarization based on data at the individual and municipal level in Denmark from 1984 to 2002. Rising income polarization is reconfirmed when applying new polarization measures, the driving force being greater...

  1. Muon polarization in e+e- → μ+μ-

    International Nuclear Information System (INIS)

    Gary, J.W.

    1978-01-01

    A calculation of the cross section for e + e - → μ + μ - interactions is performed assuming colliding beam conditions and propagation of a neutral intermediate vector boson. From this a derivation of the expression for the longitudinal polarization of the final state μ - is made. The calculation, using relativistic, weak interaction, and field theory, demonstrates the connection between the polarization and the weak force parameters explicity

  2. Detection of antibodies specific for HLA-A,B,C,DR,DQ and DP by the erythrocyte antibody rosette inhibition (EAI) and immune phagocytosis inhibition (IPI) tests.

    Science.gov (United States)

    Faust, A; Neppert, J

    1987-08-24

    Two methods for the detection of murine monoclonal antibodies against determinants of the human major histocompatibility complex (MHC) were evaluated. These methods are based upon the function of Fc receptors; the erythrocyte antibody rosette inhibition test (EAI test) using B-lymphocytes and the immune phagocytosis inhibition test (IPI test) using monocytes. Compared to the EAI test the IPI test was technically easier and gave better discrimination between positive and negative results. The inhibition by antibodies of monomorphic class II MHC or polymorphic HLA-DR antigens was stronger in the IPI than in the EAI test. Antibodies against HLA-DQ and DP antigens evoked inhibition only using the EAI test. Using IgG derived from placenta in different dilutions the detection of its anti-HLA antibodies was more readily achieved in the IPI test than in the EAI test.

  3. Polarized Light Corridor Demonstrations.

    Science.gov (United States)

    Davies, G. R.

    1990-01-01

    Eleven demonstrations of light polarization are presented. Each includes a brief description of the apparatus and the effect demonstrated. Illustrated are strain patterns, reflection, scattering, the Faraday Effect, interference, double refraction, the polarizing microscope, and optical activity. (CW)

  4. Association of HLA-DQ alleles with the presence of an anti-β₂-glycoprotein I antibody in patients with recurrent miscarriage.

    Science.gov (United States)

    Chen, X; Liang, P-Y; Li, G-G; Diao, L-H; Liu, C-C; Huang, C-Y; Wu, T-H; Xu, J; Zeng, Y

    2016-01-01

    Immunogenetic studies have suggested that autoantibody production is commonly associated with particular human leukocyte antigens (HLA) class II genotypes in certain autoimmune diseases. The objective of this study was to investigate whether the production of anti-β2-glycoprotein I antibody (aβ2GPI) was associated with particular HLA-DQ alleles in patients with recurrent miscarriage (RM). The HLA-DQ genotypes in 126 patients with RM were determined using the polymerase chain reaction-sequence-specific primer method. Both the IgG and IgM isotypes of aβ2GPI were measured via enzyme-linked immunosorbent assay. Positive results for either IgG or IgM on two occasions within an interval of 12 weeks were defined as antiphospholipid antibody-positive. The frequencies of the HLA-DQA1*01:02 [odds ratio (OR) 3.4, 95% confidence interval (CI) 1.6-7.0, Pc = 0.018] and HLA-DQB1*02:01 alleles (OR 4.6, 95% CI 2.1-10.2, Pc = 9.18 × 10(-4)) were significantly increased in aβ2GPI-positive RM patients compared with aβ2GPI-negative RM patients. These results suggest that the HLA-DQA1*0102 and HLA-DQB1*0201 alleles may be involved in the production of aβ2GPI in RM patients. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  5. Power Quality Improvement Of Grid Integrated Type I Wind Turbine Generation System Operating as DSTATCOM by d-q Control Method

    Directory of Open Access Journals (Sweden)

    S V S Phani Kumar.Ch

    2016-06-01

    Full Text Available In recent years with the excessive consumption of electrical energy, the incongruity between generation and demand, the irrational structure of World’s energy as well as the environmental pollution have become progressively more evident. It has become crucial for ecological development to reduce the consumption of conventional energy and to enhance the development and utilization of renewable energy. Wind energy and Solar are unlimited supply of renewable energy and it has no pollution. But this concept suffer from the power quality issues from grid and generator side, this paper presents a control strategy for achieving maximum benefits from these grid-interfacing inverter when installed in 3-phase 4-wire distribution systems. The inverter can be controlled to perform as a multi-function device by incorporating active power filter functionality. The inverter can thus be utilized as: 1 power converter to inject power generated from RES to the grid and 2 shunt APF (Active Power Filter to compensate current unbalance, load current harmonics, load reactive power demand and load neutral current. All of these functions may be accomplished either individually or simultaneously. With such a control, the combination of grid-interfacing inverter and the 3-phase 4-wire linear/non-linear unbalanced load at point of common coupling appears as balanced linear load to the grid. The Paper propose design of 500kW Type I Wind Generation System 250kW each with Four Leg Inverter Controlled by d-q technique operated as DSTATCOM connected to 415V 4 wire Grid and also the results are compared with conventional Unit Vector Control. The proposed d-q method reduces the %THD of system to 1.97% from 24.12% where Unit Vector Control is of 3.94% which was on higher side , this is simulated in MATLAB/SIMULINK.

  6. Intermediate Infrastructure Analyst | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The incumbent conducts research on technologies and tools that might enhance service delivery and where appropriate, makes recommendations to management. The Intermediate Infrastructure System Analyst provides leadership and direction to junior team members and functional direction to consultants and ...

  7. Polarized Moessbauer transitions

    International Nuclear Information System (INIS)

    Barb, D.

    1975-01-01

    Theoretical aspects of the emission, absorption and scattering of polarized gamma rays are reviewed for a general case of combined magnetic and electric hyperfine interactions; various possibilities of obtaining polarized gamma sources are described and examples are given of the applications of Moessbauer spectroscopy with polarized gamma rays in solving problems of solid state physics. (A.K.)

  8. Spin observables in proton-neutron scattering at intermediate energy

    International Nuclear Information System (INIS)

    Spinka, H.

    1986-05-01

    A summary of np elastic scattering spin measurements at intermediate energy is given. Preliminary results from a LAMPF experiment to measure free neutron-proton elastic scattering spin-spin correlation parameters are presented. A longitudinally polarized proton target was used. These measurements are part of a program to determine the neutron-proton amplitudes in a model independent fashion at 500, 650, and 800 MeV. Some new proton-proton total cross sections in pure helicity states (Δσ/sub L/(pp)) near 3 GeV/c are also given. 37 refs., 2 figs

  9. Isobaric intermediate states in proton-nucleus elastic scattering

    International Nuclear Information System (INIS)

    Auger, J.P.; Lazard, C.; Lombard, R.J.

    1981-05-01

    The effects of the propagation of isobaric nucleon states in the intermediate steps of the multiple scattering have been studied with application on the proton- 4 He elastic scattering at 1 GeV. The calculations are performed in the Glauber model and results are given for the differential cross section, the polarization and the spin rotation parameter. In our conclusions we stress the large cancellations observed between terms of various orders and the great sensitivity of the effects to the nucleon-nucleon amplitudes

  10. The Physics of Polarization

    Science.gov (United States)

    Landi Degl'Innocenti, Egidio

    2015-10-01

    The introductory lecture that has been delivered at this Symposium is a condensed version of an extended course held by the author at the XII Canary Island Winter School from November 13 to November 21, 2000. The full series of lectures can be found in Landi Degl'Innocenti (2002). The original reference is organized in 20 Sections that are here itemized: 1. Introduction, 2. Description of polarized radiation, 3. Polarization and optical devices: Jones calculus and Muller matrices, 4. The Fresnel equations, 5. Dichroism and anomalous dispersion, 6. Polarization in everyday life, 7. Polarization due to radiating charges, 8. The linear antenna, 9. Thomson scattering, 10. Rayleigh scattering, 11. A digression on Mie scattering, 12. Bremsstrahlung radiation, 13. Cyclotron radiation, 14. Synchrotron radiation, 15. Polarization in spectral lines, 16. Density matrix and atomic polarization, 17. Radiative transfer and statistical equilibrium equations, 18. The amplification condition in polarized radiative transfer, and 19. Coupling radiative transfer and statistical equilibrium equations.

  11. Proceedings of the fifth course of the international school of intermediate energy nuclear physics

    Energy Technology Data Exchange (ETDEWEB)

    Bergere, R.; Costa, S.; Schaerf, C.

    1985-01-01

    This book presents the papers given at a conference on high energy physics. Topics considered at the conference included total photon absorption, scattering of photons by nuclei, pion photoproduction, nuclear structure investigations, photonuclear reactions and dispersion relations, photon spectra, quark effects, future accelerators for intermediate energy nuclear physics, bag models, polarized photons, and inelastic electron scattering.

  12. Radiolysis studies on reactive intermediates

    International Nuclear Information System (INIS)

    Kevan, L.

    1977-11-01

    A more quantitative characterization of the structure and reaction mechanism of solvated electrons produced by high energy chemistry was developed. Neutral atoms may undergo solvation in polar media to cause significant geometrical rearrangement. The geometrical arrangement of six OH bond oriented water molecules around a localized electron is the preferred geometry in frozen aqueous systems even at low solute ion concentration. The energy level structure of electrons in polar aqueous and alcoholic glasses was systematized from a comparison of photoconductivity and optical spectra. Experimental and theoretical evidence on electron solvation was evaluated to suggest the dominance of first solvation shell orientation in the solvation process. A laser photolysis study as a function of temperature suggests that electron solvation in ethanol glass occurs by a hindered molecular reorientation mechanism. In mixed polar and nonpolar glassy matrices it was shown that the electron is first solvated in the nonpolar matrix and is later transformed to a more stable species surrounded by the polar molecules. It was found that the spin lattice relaxation of solvated electrons is dominated by a new mechanism characteristic of disordered matrices which involves relaxation by tunneling modes in the matrix. The noninteracting spin packet model of electron spin resonance lines was shown to apply to solvated electrons in deuterated matrices but not in protiated matrices. A new type of recombination fluorescence experiment was devised which allows easy distinction between tunnelling and diffusive recombination mechanisms between solvate electrons and cations. Several theoretical studies have helped to delimit the applicability of an electron tunneling mechanism to solvated electron reactions. Electron spin echospectrometry was used to demonstrate that silver atoms undergo dramatic solvation and desolvation changes in frozen aqueous systems

  13. [Review] Polarization and Polarimetry

    Science.gov (United States)

    Trippe, Sascha

    2014-02-01

    Polarization is a basic property of light and is fundamentally linked to the internal geometry of a source of radiation. Polarimetry complements photometric, spectroscopic, and imaging analyses of sources of radiation and has made possible multiple astrophysical discoveries. In this article I review (i) the physical basics of polarization: electromagnetic waves, photons, and parameterizations; (ii) astrophysical sources of polarization: scattering, synchrotron radiation, active media, and the Zeeman, Goldreich-Kylafis, and Hanle effects, as well as interactions between polarization and matter (like birefringence, Faraday rotation, or the Chandrasekhar-Fermi effect); (iii) observational methodology: on-sky geometry, influence of atmosphere and instrumental polarization, polarization statistics, and observational techniques for radio, optical, and X/γ wavelengths; and (iv) science cases for astronomical polarimetry: solar and stellar physics, planetary system bodies, interstellar matter, astrobiology, astronomical masers, pulsars, galactic magnetic fields, gamma-ray bursts, active galactic nuclei, and cosmic microwave background radiation.

  14. Polarization feedback laser stabilization

    Science.gov (United States)

    Esherick, P.; Owyoung, A.

    1987-09-28

    A system for locking two Nd:YAG laser oscillators includes an optical path for feeding the output of one laser into the other with different polarizations. Elliptical polarization is incorporated into the optical path so that the change in polarization that occurs when the frequencies coincide may be detected to provide a feedback signal to control one laser relative to the other. 4 figs.

  15. Polarization in Sagittarius A*

    OpenAIRE

    Bower, Geoffrey C.

    2000-01-01

    We summarize the current state of polarization observations of Sagittarius A*, the compact radio source and supermassive black hole candidate in the Galactic Center. These observations are providing new tools for understanding accretion disks, jets and their environments. Linear polarization observations have shown that Sgr A* is unpolarized at frequencies as high as 86 GHz. However, recent single-dish observations indicate that Sgr A* may have strong linear polarization at frequencies higher...

  16. Airborne Laser Polarization Sensor

    Science.gov (United States)

    Kalshoven, James, Jr.; Dabney, Philip

    1991-01-01

    Instrument measures polarization characteristics of Earth at three wavelengths. Airborne Laser Polarization Sensor (ALPS) measures optical polarization characteristics of land surface. Designed to be flown at altitudes of approximately 300 m to minimize any polarizing or depolarizing effects of intervening atmosphere and to look along nadir to minimize any effects depending on look angle. Data from measurements used in conjunction with data from ground surveys and aircraft-mounted video recorders to refine mathematical models used in interpretation of higher-altitude polarimetric measurements of reflected sunlight.

  17. Polarization at SLC

    International Nuclear Information System (INIS)

    Swartz, M.L.

    1988-07-01

    The SLAC Linear Collider has been designed to readily accommodate polarized electron beams. Considerable effort has been made to implement a polarized source, a spin rotation system, and a system to monitor the beam polarization. Nearly all major components have been fabricated. At the current time, several source and polarimeter components have been installed. The installation and commissioning of the entire system will take place during available machine shutdown periods as the commissioning of SLC progresses. It is expected that a beam polarization of 45% will be achieved with no loss in luminosity. 13 refs., 15 figs

  18. ESL intermediate/advanced writing

    CERN Document Server

    Munoz Page, Mary Ellen; Jaskiewicz, Mary

    2011-01-01

    Master ESL (English as a Second Language) Writing with the study guide designed for non-native speakers of English. Skill-building lessons relevant to today's topics help ESL students write complete sentences, paragraphs, and even multi-paragraph essays. It's perfect for classroom use or self-guided writing preparation.DETAILS- Intermediate drills for improving skills with parallel structure, mood, correct shifting errors & dangling participles- Advanced essay drills focusing on narrative, descriptive, process, reaction, comparison and contrast- Superb preparation for students taking the TOEFL

  19. Intermediate neutron detection by thermoluminescence

    International Nuclear Information System (INIS)

    Santos, E.N. dos; Muccillo, R.

    1979-01-01

    Thermoluminescent (TL) studies were carried out in cold-pressed CaSO 4 :Dy + Dy 2 O 3 + KCl and CaF 2 + Dy 2 O 3 + KCl polycrystalline samples exposed to mixed neutron-gamma fields, for the detection of intermediate neutrons which is based on the evaluation of the TL signal of the specimens stored for 24 hours after being exposed to a mixed neutron-gamma field and thermally annealed to erase the total radiation-induced TL. The addition of Dy 2 O 3 to CaSO 4 :Dy in the proportion 1:2 increased the neutron response by a factor of 160 relative to that of CaSO 4 :Dy. 180 mg of CaSO 4 :Dy + Dy 2 O 3 + KCl in the proportion 2:1:3 showed to be an appropriate detector of intermediate neutrons; the minimum detectable fluence was estimated to be 3.5 x 10 5 neutrons/cm 2 . (Author) [pt

  20. High value of the radiobiological parameter Dq correlates to expression of the transforming growth factor beta type II receptor in a panel of small cell lung cancer cell lines

    DEFF Research Database (Denmark)

    Hougaard, S; Krarup, M; Nørgaard, P

    1998-01-01

    Our panel of SCLC cell lines have previously been examined for their radiobiological characteristics and sensitivity to treatment with TGF beta 1. In this study we examined the possible correlations between radiobiological parameters and the expression of the TGF beta type II receptor (TGF beta......-rII). We have, in other studies, shown that the presence of TGF beta-rII was mandatory for transmitting the growth inhibitory effect of TGF beta. The results showed a statistically significant difference in Dq, i.e. the shoulder width of the survival curve, between cell lines expressing TGF beta......-rII and cell lines which did not express the receptor (P = 0.01). Cell lines expressing TGF beta-rII had a high Dq-value. TGF beta-rII expression did not correlate with any other radiobiological parameters. We suggest that an intact growth inhibitory pathway mediated by the TGF beta-rII may have a significant...

  1. RHIC Polarized proton operation

    International Nuclear Information System (INIS)

    Huang, H.; Ahrens, L.; Alekseev, I.G.; Aschenauer, E.; Atoian, G.; Bai, M.; Bazilevsky, A.; Blaskiewicz, M.; Brennan, J.M.; Brown, K.A.; Bruno, D.; Connolly, R.; Dion, A.; D'Ottavio, T.; Drees, K.A.; Fischer, W.; Gardner, C.; Glenn, J.W.; Gu, X.; Harvey, M.; Hayes, T.; Hoff, L.; Hulsart, R.L.; Laster, J.; Liu, C.; Luo, Y.; MacKay, W.W.; Makdisi, Y.; Marr, G.J.; Marusic, A.; Meot, F.; Mernick, K.; Michnoff, R.; Minty, M.; Montag, C.; Morris, J.; Nemesure, S.; Poblaguev, A.; Ptitsyn, V.; Ranjibar, V.; Robert-Demolaize, G.; Roser, T.; Schmidke, B.; Schoefer, V.; Severino, F.; Smirnov, D.; Smith, K.; Steski, D.; Svirida, D.; Tepikian, S.; Trbojevic, D.; Tsoupas, N.; Tuozzolo, J.E.; Wang, G.; Wilinski, M.; Yip, K.; Zaltsman, A.; Zelenski, A.; Zeno, K.; Zhang, S.Y.

    2011-01-01

    The Relativistic Heavy Ion Collider (RHIC) operation as the polarized proton collider presents unique challenges since both luminosity(L) and spin polarization(P) are important. With longitudinally polarized beams at the experiments, the figure of merit is LP 4 . A lot of upgrades and modifications have been made since last polarized proton operation. A 9 MHz rf system is installed to improve longitudinal match at injection and to increase luminosity. The beam dump was upgraded to increase bunch intensity. A vertical survey of RHIC was performed before the run to get better magnet alignment. The orbit control is also improved this year. Additional efforts are put in to improve source polarization and AGS polarization transfer efficiency. To preserve polarization on the ramp, a new working point is chosen such that the vertical tune is near a third order resonance. The overview of the changes and the operation results are presented in this paper. Siberian snakes are essential tools to preserve polarization when accelerating polarized beams to higher energy. At the same time, the higher order resonances still can cause polarization loss. As seen in RHIC, the betatron tune has to be carefully set and maintained on the ramp and during the store to avoid polarization loss. In addition, the orbit control is also critical to preserve polarization. The higher polarization during this run comes from several improvements over last run. First we have a much better orbit on the ramp. The orbit feedback brings down the vertical rms orbit error to 0.1mm, much better than the 0.5mm last run. With correct BPM offset and vertical realignment, this rms orbit error is indeed small. Second, the jump quads in the AGS improved input polarization for RHIC. Third, the vertical tune was pushed further away from 7/10 snake resonance. The tune feedback maintained the tune at the desired value through the ramp. To calibrate the analyzing power of RHIC polarimeters at any energy above

  2. RHIC Polarized proton operation

    Energy Technology Data Exchange (ETDEWEB)

    Huang, H.; Ahrens, L.; Alekseev, I.G.; Aschenauer, E.; Atoian, G.; Bai, M.; Bazilevsky, A.; Blaskiewicz, M.; Brennan, J.M.; Brown, K.A.; Bruno, D.; Connolly, R.; Dion, A.; D' Ottavio, T.; Drees, K.A.; Fischer, W.; Gardner, C.; Glenn, J.W.; Gu, X.; Harvey, M.; Hayes, T.; Hoff, L.; Hulsart, R.L.; Laster, J.; Liu, C.; Luo, Y.; MacKay, W.W.; Makdisi, Y.; Marr, G.J.; Marusic, A.; Meot, F.; Mernick, K.; Michnoff, R,; Minty, M.; Montag, C.; Morris, J.; Nemesure, S.; Poblaguev, A.; Ptitsyn, V.; Ranjibar, V.; Robert-Demolaize, G.; Roser, T.; J.; Severino, F.; Schmidke, B.; Schoefer, V.; Severino, F.; Smirnov, D.; Smith, K.; Steski, D.; Svirida, D.; Tepikian, S.; Trbojevic, D.; Tsoupas, N.; Tuozzolo, J. Wang, G.; Wilinski, M.; Yip, K.; Zaltsman, A.; Zelenski, A.; Zeno, K.; Zhang, S.Y.

    2011-03-28

    The Relativistic Heavy Ion Collider (RHIC) operation as the polarized proton collider presents unique challenges since both luminosity(L) and spin polarization(P) are important. With longitudinally polarized beams at the experiments, the figure of merit is LP{sup 4}. A lot of upgrades and modifications have been made since last polarized proton operation. A 9 MHz rf system is installed to improve longitudinal match at injection and to increase luminosity. The beam dump was upgraded to increase bunch intensity. A vertical survey of RHIC was performed before the run to get better magnet alignment. The orbit control is also improved this year. Additional efforts are put in to improve source polarization and AGS polarization transfer efficiency. To preserve polarization on the ramp, a new working point is chosen such that the vertical tune is near a third order resonance. The overview of the changes and the operation results are presented in this paper. Siberian snakes are essential tools to preserve polarization when accelerating polarized beams to higher energy. At the same time, the higher order resonances still can cause polarization loss. As seen in RHIC, the betatron tune has to be carefully set and maintained on the ramp and during the store to avoid polarization loss. In addition, the orbit control is also critical to preserve polarization. The higher polarization during this run comes from several improvements over last run. First we have a much better orbit on the ramp. The orbit feedback brings down the vertical rms orbit error to 0.1mm, much better than the 0.5mm last run. With correct BPM offset and vertical realignment, this rms orbit error is indeed small. Second, the jump quads in the AGS improved input polarization for RHIC. Third, the vertical tune was pushed further away from 7/10 snake resonance. The tune feedback maintained the tune at the desired value through the ramp. To calibrate the analyzing power of RHIC polarimeters at any energy above

  3. Evaluation of Association Between HLA Class II DR4–DQ8 Haplotype and Type I Diabetes Mellitus in Children of East Azerbaijan State of Iran

    Directory of Open Access Journals (Sweden)

    Nasrin Sohrabi

    2015-04-01

    Full Text Available Purpose: Association between HLA-DR4–DQ8 haplotype and type 1 Diabetes Mellitus (DM-1A was investigated in children of East Azerbaijan state of Iran because such an association has not been previously studied in this population. Methods: HLA-typing was performed by polymerase chain reaction sequence-specific priming. For haplotype analysis, the logistic regression model was performed. Results: Of the three investigated alleles, the frequency of DRB1*0401 was significantly higher among patients compared with that in healthy subjects (76.74% vs. 23.26%. Conclusion: The findings of the current study are consistent with those of previous studies and show that DRB1*0401 is associated with DM-1A; the frequencies of the two other alleles were also higher among patients, although the differences were not statistically significant. Two haplotypes associated with these alleles were also surveyed, and DRB1*0401−-DQA1*0301−, and DRB1*0401−-DQA1*0301−-DQB1*0302− were the most frequent haplotypes among the patient group.

  4. Our Polar Past

    Science.gov (United States)

    Clary, Renee; Wandersee, James

    2009-01-01

    The study of polar exploration is fascinating and offers students insights into the history, culture, and politics that affect the developing sciences at the farthest ends of Earth. Therefore, the authors think there is value in incorporating polar exploration accounts within modern science classrooms, and so they conducted research to test their…

  5. Terahertz polarization imaging

    NARCIS (Netherlands)

    Van der Valk, N.C.J.; Van der Marel, W.A.M.; Planken, P.C.M.

    2005-01-01

    We present a new method to measure the polarization state of a terahertz pulse by using a modified electrooptic sampling setup. To illustrate the power of this method, we show two examples in which the knowledge of the polarization of the terahertz pulse is essential for interpreting the results:

  6. Polarized proton beams

    International Nuclear Information System (INIS)

    Roser, T.

    1995-01-01

    The acceleration of polarized proton beams in circular accelerators is complicated by the presence of numerous depolarizing spin resonances. Careful and tedious minimization of polarization loss at each of these resonances allowed acceleration of polarized proton beams up to 22 GeV. It has been the hope that Siberian Snakes, which are local spin rotators inserted into ring accelerators, would eliminate these resonances and allow acceleration of polarized beams with the same ease and efficiency that is now routine for unpolarized beams. First tests at IUCF with a full Siberian Snake showed that the spin dynamics with a Snake can be understood in detail. The author now has results of the first tests of a partial Siberian Snake at the AGS, accelerating polarized protons to an energy of about 25 GeV. These successful tests of storage and acceleration of polarized proton beams open up new possibilities such as stored polarized beams for internal target experiments and high energy polarized proton colliders

  7. Polar Science Is Cool!

    Science.gov (United States)

    Weeks, Sophie

    2012-01-01

    Children are fascinated by the fact that polar scientists do research in extremely cold and dangerous places. In the Arctic they might be viewed as lunch by a polar bear. In the Antarctic, they could lose toes and fingers to frostbite and the wind is so fast it can rip skin off. They camp on ice in continuous daylight, weeks from any form of…

  8. Chirality of Intermediate Filaments and Magnetic Helicity of Active Regions

    Science.gov (United States)

    Lim, Eun-Kyung; Chae, J.

    2009-05-01

    Filaments that form either between or around active regions (ARs) are called intermediate filaments. Even though there have been many theoretical studies, the origin of the chirality of filaments is still unknown. We investigated how intermediate filaments are related to their associated ARs, especially from the point of view of magnetic helicity and the orientation of polarity inversion lines (PILs). The chirality of filaments has been determined based on the orientations of barbs observed in the full-disk Hα images taken at Big Bear Solar Observatory during the rising phase of solar cycle 23. The sign of magnetic helicity of ARs has been determined using S/inverse-S shaped sigmoids from Yohkoh SXT images. As a result, we have found a good correlation between the chirality of filaments and the magnetic helicity sign of ARs. Among 45 filaments, 42 filaments have shown the same sign as helicity sign of nearby ARs. It has been also confirmed that the role of both the orientation and the relative direction of PILs to ARs in determining the chirality of filaments is not significant, against a theoretical prediction. These results suggest that the chirality of intermediate filaments may originate from magnetic helicity of their associated ARs.

  9. Precision Polarization of Neutrons

    Science.gov (United States)

    Martin, Elise; Barron-Palos, Libertad; Couture, Aaron; Crawford, Christopher; Chupp, Tim; Danagoulian, Areg; Estes, Mary; Hona, Binita; Jones, Gordon; Klein, Andi; Penttila, Seppo; Sharma, Monisha; Wilburn, Scott

    2009-05-01

    Determining polarization of a cold neutron beam to high precision is required for the next generation neutron decay correlation experiments at the SNS, such as the proposed abBA and PANDA experiments. Precision polarimetry measurements were conducted at Los Alamos National Laboratory with the goal of determining the beam polarization to the level of 10-3 or better. The cold neutrons from FP12 were polarized using optically polarized ^3He gas as a spin filter, which has a highly spin-dependent absorption cross section. A second ^ 3He spin filter was used to analyze the neutron polarization after passing through a resonant RF spin rotator. A discussion of the experiment and results will be given.

  10. Optically polarized 3He

    Science.gov (United States)

    Gentile, T. R.; Nacher, P. J.; Saam, B.; Walker, T. G.

    2018-01-01

    This article reviews the physics and technology of producing large quantities of highly spin-polarized 3He nuclei using spin-exchange (SEOP) and metastability-exchange (MEOP) optical pumping. Both technical developments and deeper understanding of the physical processes involved have led to substantial improvements in the capabilities of both methods. For SEOP, the use of spectrally narrowed lasers and K-Rb mixtures has substantially increased the achievable polarization and polarizing rate. For MEOP nearly lossless compression allows for rapid production of polarized 3He and operation in high magnetic fields has likewise significantly increased the pressure at which this method can be performed, and revealed new phenomena. Both methods have benefitted from development of storage methods that allow for spin-relaxation times of hundreds of hours, and specialized precision methods for polarimetry. SEOP and MEOP are now widely applied for spin-polarized targets, neutron spin filters, magnetic resonance imaging, and precision measurements. PMID:29503479

  11. Optically polarized 3He

    Science.gov (United States)

    Gentile, T. R.; Nacher, P. J.; Saam, B.; Walker, T. G.

    2017-10-01

    This article reviews the physics and technology of producing large quantities of highly spin-polarized 3He nuclei using spin-exchange (SEOP) and metastability-exchange (MEOP) optical pumping. Both technical developments and deeper understanding of the physical processes involved have led to substantial improvements in the capabilities of both methods. For SEOP, the use of spectrally narrowed lasers and K-Rb mixtures has substantially increased the achievable polarization and polarizing rate. For MEOP nearly lossless compression allows for rapid production of polarized 3He and operation in high magnetic fields has likewise significantly increased the pressure at which this method can be performed, and revealed new phenomena. Both methods have benefitted from development of storage methods that allow for spin-relaxation times of hundreds of hours, and specialized precision methods for polarimetry. SEOP and MEOP are now widely applied for spin-polarized targets, neutron spin filters, magnetic resonance imaging, and precision measurements.

  12. Parallel Polarization State Generation.

    Science.gov (United States)

    She, Alan; Capasso, Federico

    2016-05-17

    The control of polarization, an essential property of light, is of wide scientific and technological interest. The general problem of generating arbitrary time-varying states of polarization (SOP) has always been mathematically formulated by a series of linear transformations, i.e. a product of matrices, imposing a serial architecture. Here we show a parallel architecture described by a sum of matrices. The theory is experimentally demonstrated by modulating spatially-separated polarization components of a laser using a digital micromirror device that are subsequently beam combined. This method greatly expands the parameter space for engineering devices that control polarization. Consequently, performance characteristics, such as speed, stability, and spectral range, are entirely dictated by the technologies of optical intensity modulation, including absorption, reflection, emission, and scattering. This opens up important prospects for polarization state generation (PSG) with unique performance characteristics with applications in spectroscopic ellipsometry, spectropolarimetry, communications, imaging, and security.

  13. Polar reactions of acyclic conjugated bisallenes

    Directory of Open Access Journals (Sweden)

    Reiner Stamm

    2013-01-01

    Full Text Available The chemical behaviour of various alkyl-substituted, acyclic conjugated bisallenes in reactions involving polar intermediates and/or transition states has been investigated on a broad scale for the first time. The reactions studied include lithiation, reaction of the thus formed organolithium salts with various electrophiles (among others, allyl bromide, DMF and acetone, oxidation to cyclopentenones and epoxides, hydrohalogenation (HCl, HBr addition, halogenation (Br2 and I2 addition, and [2 + 2] cycloaddition with chlorosulfonyl isocyanate. The resulting adducts were fully characterized by spectroscopic and analytical methods; they constitute interesting substrates for further organic transformations.

  14. Geomagnetic excursions reflect an aborted polarity state

    Science.gov (United States)

    Valet, Jean-Pierre; Plenier, Guillaume; Herrero-Bervera, E.

    2008-10-01

    Geomagnetic excursions represent short episodes of a few thousand years at most during which the field considerably exceeds its normal range of variability during a polarity state. Paleomagnetic records have now been obtained with extremely high temporal resolution which have improved our knowledge of these short events. We have compiled the most detailed records of excursions that had occurred during the Brunhes and Matuyama chrons. We show that virtual geomagnetic poles (VGPs) of at least one record of each event are able to reach the opposite polarity. In the next step, we have computed different simulations of excursions during which the dipole progressively vanishes before growing back without reversing. This scenario produces very few reversed directions which are only visible at some latitudes. We infer that it is impossible to reach the ratio of reversed to intermediate VGPs present in the paleomagnetic records if the excursions were not associated with a short period of reversed dipole field. Therefore, excursions should be regarded as two successive reversals bracketing an aborted polarity interval. We propose that the same underlying mechanisms prevail in both situations (excursions or reversals) and that below a certain strength the field reaches an unstable position which preludes either the achievement of a reversal or its return to the former polarity.

  15. Intermediate processes in nuclear reactions

    International Nuclear Information System (INIS)

    Petrovici, M.

    1983-01-01

    The main results presented here cannot be interpreted in terms of the direct reaction model or the statistical models and one can more or less explicitely use some nuclear configurations for their interpretation. The first chapter deals with the so-called second order intermediate structures observed in the elastic and inelastic proton scattering on 66 Zn and 70 Ge targets in the energetic regions of some isobaric analog resonances. A formal theory for their interpretation is developed and the comparison with the experimental data is presented. New experimental results on the resonant structures observed in the elastic and inelastic scattering of 12 C on 24 Mg are presented in the second chapter. Detailed statistical analysis and their interpretation is presented too. Charge equilibration in deep inelastic collisions is the main subject of the third chapter. The experimental results obtained by the 98 Mo + 154 Sm collision at 12 MeV/n, a quantum treatment of a damped harmonic oscillator and the comparison with the experimental data are given. In the last chapter, some results on the existence of two other processes which could candidate to be involved in the main topic are presented. Those processes are: the fast fragmentation and preequilibrium charged particles emission. All these processes originate in the excitation of some simple configurations which can be seen on ''doorway'' states (''Hallway'' in the case of the second intermediate structures). The coupling of these states to other more complicated excitation modes of the nuclei and to outgoing channel=gives the possibility to study the nuclear dynamics. This justifies the interest for their detailed theoretical and experimental investigations. (author)

  16. Polarization at the SLC

    Energy Technology Data Exchange (ETDEWEB)

    Moffeit, K.C.

    1988-10-01

    The Stanford Linear collider was designed to accommodate polarized electron beams. Longitudinally polarized electrons colliding with unpolarized positrons at a center of mass energy near the Z/sup 0/ mass can be used as novel and sensitive probes of the electroweak process. A gallium arsenide based photon emission source will provide a beam of longitudinally polarized electrons of about 45 percent polarization. A system of bend magnets and a superconducting solenoid will be used to rotate the spins so that the polarization is preserved while the 1.21 GeV electrons are stored in the damping ring. Another set of bend magnets and two superconducting solenoids orient the spin vectors so that longitudinal polarization of the electrons is achieved at the collision point with the unpolarized positrons. A system to monitor the polarization based on Moller and Compton scattering will be used. Nearly all major components have been fabricated and tested. Subsystems of the source and polarimeters have been installed, and studies are in progress. The installation and commissioning of the entire system will take place during available machine shutdown periods as the commissioning of SLC progresses. 8 refs., 16 figs., 1 tab.

  17. Polarized atomic beams for targets

    International Nuclear Information System (INIS)

    Grueebler, W.

    1984-01-01

    The basic principle of the production of polarized atomic hydrogen and deuterium beams are reviewed. The status of the present available polarization, density and intensity are presented. The improvement of atomic beam density by cooling the hydrogen atoms to low velocity is discussed. The possible use of polarized atomic beams as targets in storage rings is shown. It is proposed that polarized atomic beams can be used to produce polarized gas targets with high polarization and greatly improved density

  18. Polarized scintillator targets

    Science.gov (United States)

    van den Brandt, B.; Bunyatova, E. I.; Hautle, P.; Konter, J. A.; Mango, S.

    2000-05-01

    The hydrogen nuclei in an organic scintillator have been polarized to more than 80% and the deuterons in its fully deuterated version to 24%. The scintillator, doped with TEMPO, has been polarized dynamically in a field of 2.5 T in a vertical dilution refrigerator in which a plastic lightguide transports the scintillation light from the sample in the mixing chamber to a photomultiplier outside the cryostat. Sizeable solid samples with acceptable optical properties and light output have been prepared and successfully operated as "live" polarized targets in nuclear physics experiments.

  19. Polarized scintillator targets

    Energy Technology Data Exchange (ETDEWEB)

    Brandt, B. van den E-mail: vandenbrandt@psi.ch; Bunyatova, E.I.; Hautle, P.; Konter, J.A.; Mango, S

    2000-05-21

    The hydrogen nuclei in an organic scintillator have been polarized to more than 80% and the deuterons in its fully deuterated version to 24%. The scintillator, doped with TEMPO, has been polarized dynamically in a field of 2.5 T in a vertical dilution refrigerator in which a plastic lightguide transports the scintillation light from the sample in the mixing chamber to a photomultiplier outside the cryostat. Sizeable solid samples with acceptable optical properties and light output have been prepared and successfully operated as 'live' polarized targets in nuclear physics experiments.

  20. Heidelberg polarized alkali source

    International Nuclear Information System (INIS)

    Kraemer, D.; Steffens, E.; Jaensch, H.; Philipps Universitaet, Marburg, Germany)

    1984-01-01

    A new atomic beam type polarized alkali ion source has been installed at Heidelberg. In order to improve the beam polarization considerably optical pumping is applied in combination with an adiabatic medium field transition which results in beams in single hyperfine sublevels. The m state population is determined by laser-induced fluorescence spectroscopy. Highly polarized beams (P/sub s/ > 0.9, s = z, zz) with intensities of 30 to 130 μA can be extracted for Li + and Na + , respectively

  1. Polarization measurement in the COMPASS polarized target

    CERN Document Server

    Kondo, K; Baum, G; Berglund, P; Doshita, N; Gautheron, F; Görtz, S; Hasegawa, T; Horikawa, N; Ishimoto, S; Iwata, T; Kisselev, Yu V; Koivuniemi, J H; Le Goff, J M; Magnon, A; Meyer, W; Reicherz, G; Matsuda, T

    2004-01-01

    Continuous wave nuclear magnetic resonance (NMR) is used to determine the target polarization in the COMPASS experiment. The system is made of the so-called Liverpool Q-meters, Yale-cards, and VME modules for data taking and system controlling. In 2001 the NMR coils were embedded in the target material, while in 2002 and 2003 the coils were mounted on the outer surface of the target cells to increase the packing factor of the material. Though the error of the measurement became larger with the outer coils than with the inner coils, we have performed stable measurements throughout the COMPASS run time for 3 years. The maximum polarization was +57% and -53% as the average in the target cells.

  2. RHIZOME AND DISCOURSE OF INTERMEDIALITY

    Directory of Open Access Journals (Sweden)

    Л Н Синельникова

    2017-12-01

    Full Text Available Rhizomaticity is a strategy and a regularity of text creation in a lot of modern commu-nicative discourse practices. What remains urgent is the problem of the systematic interdisciplinary de-scription of texts whose structure and language qualities are determined by the signs of the rhizome - a concept of post-modern philosophy introduced into the scientific field by the French philosopher Gilles Deleuze and the psychotherapist Félix Guattari (Deleuze, Guattari 1996. The rhizome (Fr. rhizome - rootstock, tuber, bulb, mycelium possesses the following qualities: it is non-linear, open and directed towards the unpredictability of discourse transformations through the possibilities of structure development in any direction; there is no centre or periphery in the rhizome, and any discourse element can become ‘a vital structure’ for text-creation. The rhizome does not have non-intersecting boundaries; and in the space of the rhizomatic discourse environment, an increase of reality facets takes place, non-standard associative con-nections appear, multiplication effects are formed, which create new meanings. Rhizomaticity is the quality of texts being organised by the laws of rhizomatic logic (V.F. Sharkov 2007, by the terms of which ‘su-perposition’ of discourses can take place, a transition from one semiotic system to another. The article makes an attempt to correlate the qualities of the rhizome with the signs of the intermedia discourse, which is built on the semiotic interaction of different media. The moving lines of the rhizome, its ‘branch-ing’ qualities can be found in poetic texts, in the evaluating segments of political discourse, in advertising discourse, in internet communications, which represent rhizomorphic environments. An analysis of examples from these spheres has shown that the rhizomatic approach opens new facets of intermediality. The author uses the methods of discourse analysis to prove that the openness and non

  3. Dynamic nuclear spin polarization

    Energy Technology Data Exchange (ETDEWEB)

    Stuhrmann, H.B. [GKSS-Forschungszentrum Geesthacht GmbH (Germany)

    1996-11-01

    Polarized neutron scattering from dynamic polarized targets has been applied to various hydrogenous materials at different laboratories. In situ structures of macromolecular components have been determined by nuclear spin contrast variation with an unprecedented precision. The experiments of selective nuclear spin depolarisation not only opened a new dimension to structural studies but also revealed phenomena related to propagation of nuclear spin polarization and the interplay of nuclear polarisation with the electronic spin system. The observation of electron spin label dependent nuclear spin polarisation domains by NMR and polarized neutron scattering opens a way to generalize the method of nuclear spin contrast variation and most importantly it avoids precontrasting by specific deuteration. It also likely might tell us more about the mechanism of dynamic nuclear spin polarisation. (author) 4 figs., refs.

  4. Time Domain Induced Polarization

    DEFF Research Database (Denmark)

    Fiandaca, Gianluca; Auken, Esben; Christiansen, Anders Vest

    2012-01-01

    Time-domain-induced polarization has significantly broadened its field of reference during the last decade, from mineral exploration to environmental geophysics, e.g., for clay and peat identification and landfill characterization. Though, insufficient modeling tools have hitherto limited the use...... of time-domaininduced polarization for wider purposes. For these reasons, a new forward code and inversion algorithm have been developed using the full-time decay of the induced polarization response, together with an accurate description of the transmitter waveform and of the receiver transfer function......%. Furthermore, the presence of low-pass filters in time-domain-induced polarization instruments affects the early times of the acquired decays (typically up to 100 ms) and has to be modeled in the forward response to avoid significant loss of resolution. The developed forward code has been implemented in a 1D...

  5. Polarized proton colliders

    International Nuclear Information System (INIS)

    Roser, T.

    1995-01-01

    High energy polarized beam collisions will open up the unique physics opportunities of studying spin effects in hard processes. This will allow the study of the spin structure of the proton and also the verification of the many well documented expectations of spin effects in perturbative QCD and parity violation in W and Z production. Proposals for polarized proton acceleration for several high energy colliders have been developed. A partial Siberian Snake in the AGS has recently been successfully tested and full Siberian Snakes, spin rotators, and polarimeters for RHIC are being developed to make the acceleration of polarized beams to 250 GeV possible. This allows for the unique possibility of colliding two 250 GeV polarized proton beams at luminosities of up to 2 x 10 32 cm -2 s -1

  6. Plasma polarization spectroscopy

    International Nuclear Information System (INIS)

    Iwamae, Atsushi; Horimoto, Yasuhiro; Fujimoto, Takashi; Hasegawa, Noboru; Sukegawa, Kouta; Kawachi, Tetsuya

    2005-01-01

    The electron velocity distribution function (EVDF) in plasma can be anisotropic in laser-produced plasmas. We have developed a new technique to evaluate the polarization degree of the emission lines in the extreme vacuum ultra violet wavelength region. The polarization of the emission lines and the continuums from the lithium-like nitrogen and from helium- and hydrogen-like carbon in recombining plasma is evaluated. Particle simulation in the velocity space gives the time scale for relaxation of anisotropic EVDFs. (author)

  7. Ultracold Polar Molecules

    Science.gov (United States)

    2016-04-01

    AFRL-AFOSR-UK-TR-2016-0005 Ultracold Polar Molecules Jeremy Hutson UNIVERSITY OF DURHAM Final Report 04/01/2016 DISTRIBUTION A: Distribution approved...DATES COVERED (From - To) 15-Jan-2010 to 14-Jul-2015 4. TITLE AND SUBTITLE Final Report on Grant FA8655-10-1-3033 on Ultracold Polar Molecules 5a...formation of ultracold 87RbCs molecules in their rovibrational ground state by magnetoassociation followed by STIRAP, resulting in 14 papers acknowledging

  8. On financial equilibrium with intermediation costs

    DEFF Research Database (Denmark)

    Markeprand, Tobias Ejnar

    2008-01-01

    This paper studies the set of competitive equilibria in financial economies with intermediation costs. We consider an arbitrary dividend structure, which includes options and equity with limited liabilities.We show a general existence result and upper-hemi continuity of the equilibrium...... correspondence. Finally, we prove that when intermediation costs approach zero, unbounded volume of asset trades is a necessary and sufficient condition, provided that, there is no financial equilibrium without intermediation costs....

  9. Biocatalytic Synthesis of Chiral Pharmaceutical Intermediates

    Directory of Open Access Journals (Sweden)

    Ramesh N. Patel

    2004-01-01

    Full Text Available The production of single enantiomers of drug intermediates has become increasingly important in the pharmaceutical industry. Chiral intermediates and fine chemicals are in high demand from both the pharmaceutical and agrochemical industries for the preparation of bulk drug substances and agricultural products. The enormous potential of microorganisms and enzymes for the transformation of synthetic chemicals with high chemo-, regio- and enantioselectivities has been demonstrated. In this article, biocatalytic processes are described for the synthesis of chiral pharmaceutical intermediates.

  10. HLA DQ2 HAPLOTYPE, EARLY ONSET OF GRAVES DISEASE, AND POSITIVE FAMILY HISTORY OF AUTOIMMUNE DISORDERS ARE RISK FACTORS FOR DEVELOPING CELIAC DISEASE IN PATIENTS WITH GRAVES DISEASE.

    Science.gov (United States)

    Miskiewicz, Piotr; Gos-Zajac, Agata; Kurylowicz, Alina; Plazinska, Teresa Maria; Franaszczyk, Maria; Bartoszewicz, Zbigniew; Kondracka, Agnieszka; Pirko-Kotela, Katarzyna; Rupinski, Maciej; Jarosz, Dorota; Regula, Jaroslaw; Ploski, Rafal; Bednarczuk, Tomasz

    2015-09-01

    The diagnosis of celiac disease (CD) in patients with different autoimmune diseases including Graves disease (GD) remains a challenge. The aims of our study were to: (1) assess the prevalence of CD in Polish patients with GD and (2) evaluate the prevalence of CD in the subgroups of patients with GD divided on the basis of clinical and human leukocyte antigen (HLA) typing criteria. The prospective study was conducted at an academic referral center. The study groups consisted of consecutive, euthyroid patients with GD (n = 232) and healthy volunteers without autoimmune thyroid diseases (n = 122). The diagnosis of CD was based on elevated immunoglobulin A autoantibodies to the enzyme tissue transglutaminase (IgA-TTG) and small intestine biopsy findings. CD was diagnosed in 8 patients with GD (3.4%) and 1 healthy volunteer (0.8%). The development of CD in patients with GD was strongly associated with HLA-DQ2 haplotype (as predicted from linkage disequilibria, 14.6% vs. 1.5%, P = .009; odds ratio [OR] = 11.3; 95% confidence interval [CI] 1.3-252.7): 6 patients with CD carried HLA-DRB1(*)03, 1 carried an HLA-DRB1(*)04 allele, and 1 had an HLA-DRB1(*)07/(*)11 genotype. Multivariate analysis showed independent associations between CD and early GD onset (P = .014, OR = 9.6), autoimmunity in family (P = .029, OR = 6.3) and gastroenterologic symptoms (P = .031, OR = 8.1). The results of our study suggest that serologic screening for CD may be considered in GD patients (1) with the HLA alleles typical for CD, (2) with an early onset of GD, or (3) a family history of autoimmunity. Moreover, the diagnosis of CD should be explored in euthyroid GD patients with nonspecific gastrointestinal symptoms.

  11. Hsp Polarization Verification

    Science.gov (United States)

    Bless, Robert

    1991-07-01

    This proposal defines the procedure for determining the instrumental polarization of the polarimetric IDT (IDT#1, POL) on the HSP. 1 of 2 unpolarized standard stars wil be observed using various filter-polarizer combinations. These observations will permit the instrumental polarization to be calibrated. The instrumental polarization must be determined to a high precision in order to vectoriallly remove it from HSP polarization observations to determine the actual astronomical polarization. Final run of proposal will look at one of 2 possible stars previously observed to get another look at the throughput. Revision History: Mark H. Slovak 8/30/88 Translated to V2 proposal instructions (RPSS V6.2) S. Laurent 1/20/89 Updated: Sally Laurent 2/24/89, 3/20/89, 4/13/89, 5/12/89 Modified: P. Stanley 1/15/90 - change to use CTA selected targets only; Fixes for aberration problem - SALM 7/30/90; Based on SV/HSP 1386. New submission changed targets and revised scheduling strategy. Revised: 26 Aug 92 J. Dolan, L. Walter, P. Reppert want to re-run the proposal (3985) one last time to bring down errors.

  12. Compact Intermediate-Temperature Fuel Cells

    National Research Council Canada - National Science Library

    Sun, Yipeng

    2003-01-01

    In Phase I, we demonstrate the feasibility of making supported electronically insulating, proton conducting inorganic thin films on metal hydride foils for intermediate temperature fuel cell electrolytes...

  13. Polarized Light Microscopy

    Science.gov (United States)

    Frandsen, Athela F.

    2016-01-01

    Polarized light microscopy (PLM) is a technique which employs the use of polarizing filters to obtain substantial optical property information about the material which is being observed. This information can be combined with other microscopy techniques to confirm or elucidate the identity of an unknown material, determine whether a particular contaminant is present (as with asbestos analysis), or to provide important information that can be used to refine a manufacturing or chemical process. PLM was the major microscopy technique in use for identification of materials for nearly a century since its introduction in 1834 by William Fox Talbot, as other techniques such as SEM (Scanning Electron Microscopy), FTIR (Fourier Transform Infrared spectroscopy), XPD (X-ray Powder Diffraction), and TEM (Transmission Electron Microscopy) had not yet been developed. Today, it is still the only technique approved by the Environmental Protection Agency (EPA) for asbestos analysis, and is often the technique first applied for identification of unknown materials. PLM uses different configurations in order to determine different material properties. With each configuration additional clues can be gathered, leading to a conclusion of material identity. With no polarizing filter, the microscope can be used just as a stereo optical microscope, and view qualities such as morphology, size, and number of phases. With a single polarizing filter (single polars), additional properties can be established, such as pleochroism, individual refractive indices, and dispersion staining. With two polarizing filters (crossed polars), even more can be deduced: isotropy vs. anisotropy, extinction angle, birefringence/degree of birefringence, sign of elongation, and anomalous polarization colors, among others. With the use of PLM many of these properties can be determined in a matter of seconds, even for those who are not highly trained. McCrone, a leader in the field of polarized light microscopy, often

  14. Quasielastic nucleon scattering using polarized beams and targets

    International Nuclear Information System (INIS)

    Haeusser, O.

    1990-07-01

    Inelastic scattering of polarized intermediate energy nucleons to continuum nuclear states is discussed with emphasis on recent results. Spin momentum correlations of protons in polarized targets of 3 He were observed for the first time. Complete spin observables in (p,p') show effects of the nuclear spin-isospin response and of an NN interaction modified by the nuclear medium. A comparison of Gamow Teller and isovector M1 giant resonance strengths in the sd shell provides evidence for large meson exchange current effects in the M1. (Author) (37 refs., 2 tabs., 9 figs.)

  15. Nuclear structure at intermediate energies

    International Nuclear Information System (INIS)

    Bonner, B.E.; Mutchler, G.S.

    1991-01-01

    The theme that unites the sometimes seemingly disparate experiments undertaken by the Bonner Lab Medium Energy Group is a determination to understand in detail the many facets and manifestations of the strong interaction, that which is now referred to as nonperturbative QCD. Whether we are investigating the question of just what does carry the spin of baryons, or the extent of the validity of the SU(6) wavefunctions for the excited hyperons (as will be measured in their radiative decays in our CEBAF experiment), or questions associated with the formation of a new state of matter predicted by QCD (the subject of our BNL experiments E810, E854, as well as our approved experiment at RHIC), -- all these projects share this common goal. Our other experiments represent different approaches to the same broad undertaking. LAMPF E1097 will provide definitive answers to the question of the spin dependence of the inelastic channel of pion production in the n-p interaction. FNAL E683 may well open a new field of investigation in nuclear physics: that of just how quarks and gluons interact with nuclear matter as they transverse nuclei of different sizes. In most all of the experiments mentioned above, the Bonner Lab Group is playing major leadership roles as well as doing a big fraction of the hard work that such experiments require. We use many of the facilities that are unavailable to the intermediate energy physics community and we use our expertise to design and fabricate the detectors and instrumentation that are required to perform the measurements which we decide to do

  16. Nuclear structure at intermediate energies

    Energy Technology Data Exchange (ETDEWEB)

    Bonner, B.E.; Mutchler, G.S.

    1991-09-30

    The theme that unites the sometimes seemingly disparate experiments undertaken by the Bonner Lab Medium Energy Group is a determination to understand in detail the many facets and manifestations of the strong interaction, that which is now referred to as nonperturbative QCD. Whether we are investigating the question of just what does carry the spin of baryons, or the extent of the validity of the SU(6) wavefunctions for the excited hyperons (as will be measured in their radiative decays in our CEBAF experiment), or questions associated with the formation of a new state of matter predicted by QCD (the subject of our BNL experiments E810, E854, as well as our approved experiment at RHIC), -- all these projects share this common goal. Our other experiments represent different approaches to the same broad undertaking. LAMPF E1097 will provide definitive answers to the question of the spin dependence of the inelastic channel of pion production in the n-p interaction. FNAL E683 may well open a new field of investigation in nuclear physics: that of just how quarks and gluons interact with nuclear matter as they transverse nuclei of different sizes. In most all of the experiments mentioned above, the Bonner Lab Group is playing major leadership roles as well as doing a big fraction of the hard work that such experiments require. We use many of the facilities that are unavailable to the intermediate energy physics community and we use our expertise to design and fabricate the detectors and instrumentation that are required to perform the measurements which we decide to do.

  17. The evolution of tensor polarization

    International Nuclear Information System (INIS)

    Huang, H.; Lee, S.Y.; Ratner, L.

    1993-01-01

    By using the equation of motion for the vector polarization, the spin transfer matrix for spin tensor polarization, the spin transfer matrix for spin tensor polarization is derived. The evolution equation for the tensor polarization is studied in the presence of an isolate spin resonance and in the presence of a spin rotor, or snake

  18. Polarized Electrons at Jefferson Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Sinclair, C.K.

    1997-12-31

    The CEBAF accelerator at Jefferson laboratory can deliver CW electron beams to three experimental halls simultaneously. A large fraction of the approved scientific program at the lab requires polarized electron beams. Many of these experiments, both polarized and unpolarized, require high average beam current as well. Since all electrons delivered to the experimental halls originate from the same cathode, delivery of polarized beam to a single hall requires using the polarized source to deliver beam to all experiments in simultaneous operation. The polarized source effort at Jefferson Lab is directed at obtaining very long polarized source operational lifetimes at high average current and beam polarization; at developing the capability to deliver all electrons leaving the polarized source to the experimental halls; and at delivering polarized beam to multiple experimental halls simultaneously.initial operational experience with the polarized source will be presented.

  19. Polarized electrons at Jefferson laboratory

    International Nuclear Information System (INIS)

    The CEBAF accelerator at Jefferson laboratory can deliver CW electron beams to three experimental halls simultaneously. A large fraction of the approved scientific program at the lab requires polarized electron beams. Many of these experiments, both polarized and unpolarized, require high average beam current as well. Since all electrons delivered to the experimental halls originate from the same cathode, delivery of polarized beam to a single hall requires using the polarized source to deliver beam to all experiments in simultaneous operation. The polarized source effort at Jefferson Lab is directed at obtaining very long polarized source operational lifetimes at high average current and beam polarization; at developing the capability to deliver all electrons leaving the polarized source to the experimental halls; and at delivering polarized beam to multiple experimental halls simultaneously. Initial operational experience with the polarized source will be presented

  20. Polar low monitoring

    Science.gov (United States)

    Bobylev, Leonid; Zabolotskikh, Elizaveta; Mitnik, Leonid

    2010-05-01

    Polar lows are intense mesoscale atmospheric low pressure weather systems, developing poleward of the main baroclinic zone and associated with high surface wind speeds. Small size and short lifetime, sparse in-situ observations in the regions of their development complicate polar low study. Our knowledge of polar lows and mesocyclones has come almost entirely during the period of satellite remote sensing since, by virtue of their small horizontal scale, it was rarely possible to analyse these lows on conventional weather charts using only the data from the synoptic observing network. However, the effects of intense polar lows have been felt by coastal communities and seafarers since the earliest times. These weather systems are thought to be responsible for the loss of many small vessels over the centuries, although the nature of the storms was not understood and their arrival could not be predicted. The actuality of the polar low research is stipulated by their high destructive power: they are a threat to such businesses as oil and gas exploration, fisheries and shipping. They could worsen because of global warming: a shrinking of sea ice around the North Pole, which thawed to its record minimum in the summer of 2007, is likely to give rise to more powerful storms that form only over open water and can cause hurricane-strength winds. Therefore, study of polar lows, their timely detection, tracking and forecasting represents a challenge for today meteorology. Satellite passive microwave data, starting from Special Sensor Microwave Imager (SSM/I) onboard Defense Meteorological Satellite Program (DMSP) satellite, remain invaluable source of regularly available remotely sensed data to study polar lows. The sounding in this spectral range has several advantages in comparison with observations in visible and infrared ranges and Synthetic Aperture Radar (SAR) data: independence on day time and clouds, regularity and high temporal resolution in Polar Regions. Satellite

  1. 19 CFR 122.84 - Intermediate airport.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Intermediate airport. 122.84 Section 122.84... Intermediate airport. (a) Application. The provisions of this section apply at any U.S. airport to which an... aircraft arrives at the next airport, the aircraft commander or agent shall make entry by filing the: (1...

  2. Gasoline Engine Mechanics. Performance Objectives. Intermediate Course.

    Science.gov (United States)

    Jones, Marion

    Several intermediate performance objectives and corresponding criterion measures are listed for each of six terminal objectives presented in this curriculum guide for an intermediate gasoline engine mechanics course at the secondary level. (For the beginning course guide see CE 010 947.) The materials were developed for a two-semester (2 hour…

  3. Some Intermediate-Level Violin Concertos.

    Science.gov (United States)

    Abramson, Michael

    1997-01-01

    Contends that many violin students attempt difficult concertos before they are technically or musically prepared. Identifies a variety of concertos at the intermediate and advanced intermediate-level for students to study and master before attempting the advanced works by Bach and Mozart. Includes concertos by Vivaldi, Leclair, Viotti, Haydn,…

  4. Automotive Body Repair. Performance Objectives. Intermediate Course.

    Science.gov (United States)

    Lang, Thomas

    Several intermediate performance objectives and corresponding criterion measures are listed for each of 10 terminal objectives for an intermediate automotive body repair and refinishing course. The materials were developed for a two-semester (3 hours daily) course for specialized classrooms, shop, and practical experiences designed to enable the…

  5. 39 CFR 3001.39 - Intermediate decisions.

    Science.gov (United States)

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Intermediate decisions. 3001.39 Section 3001.39 Postal Service POSTAL REGULATORY COMMISSION PERSONNEL RULES OF PRACTICE AND PROCEDURE Rules of General Applicability § 3001.39 Intermediate decisions. (a) Initial decision by presiding officer. In any proceedings in...

  6. Brazil : Interest Rates and Intermediation Spreads

    OpenAIRE

    World Bank

    2006-01-01

    This study sheds light on the analytical and policy issues regarding the high intermediation spread in Brazil, focusing on its determinants, the reasons for its persistence, and its impact on the real economy, especially on access to finance for Brazilian firms. The key contention of the analysis is that high intermediation spreads are a symptom of underlying problems; as such, spreads constitute ...

  7. Polarized protons at RHIC

    International Nuclear Information System (INIS)

    Tannenbaum, M.J.

    1990-12-01

    The Physics case is presented for the use of polarized protons at RHIC for one or two months each year. This would provide a facility with polarizations of approx-gt 50% high luminosity ∼2.0 x 10 32 cm -2 s -1 , the possibility of both longitudinal and transverse polarization at the interaction regions, and frequent polarization reversal for control of systematic errors. The annual integrated luminosity for such running (∼10 6 sec per year) would be ∫ Ldt = 2 x 10 38 cm -2 -- roughly 20 times the total luminosity integrated in ∼ 10 years of operation of the CERN Collider (∼10 inverse picobarns, 10 37 cm -2 ). This facility would be unique in the ability to perform parity-violating measurements and polarization test of QCD. Also, the existence of p-p collisions in a new energy range would permit the study of ''classical'' reactions like the total cross section and elastic scattering, etc., and serve as a complement to measurements from p-bar p colliders. 11 refs

  8. The Bochum Polarized Target

    International Nuclear Information System (INIS)

    Reicherz, G.; Goertz, S.; Harmsen, J.; Heckmann, J.; Meier, A.; Meyer, W.; Radtke, E.

    2001-01-01

    The Bochum 'Polarized Target' group develops the target material 6 LiD for the COMPASS experiment at CERN. Several different materials like alcohols, alcanes and ammonia are under investigation. Solid State Targets are polarized in magnetic fields higher than B=2.5T and at temperatures below T=1K. For the Dynamic Nuclear Polarization process, paramagnetic centers are induced chemically or by irradiation with ionizing beams. The radical density is a critical factor for optimization of polarization and relaxation times at adequate magnetic fields and temperatures. In a high sensitive EPR--apparatus, an evaporator and a dilution cryostat with a continuous wave NMR--system, the materials are investigated and optimized. To improve the polarization measurement, the Liverpool NMR-box is modified by exchanging the fixed capacitor for a varicap diode which not only makes the tuning very easy but also provides a continuously tuned circuit. The dependence of the signal area upon the circuit current is measured and it is shown that it follows a linear function

  9. In-line Fiber Polarizer

    OpenAIRE

    Perumalsamy, Priya

    1998-01-01

    Polarizers and polarization devices are important components in fiber optic communication and sensor systems. There is a growing need for efficient low loss components that are compatible with optical fibers. An all fiber in-line polarizer is a more desirable alternative that could be placed at appropriate intervals along communication links. An in-line fiber polarizer was fabricated and tested. The in-line fiber polarizer operates by coupling optical energy propagatin...

  10. Epithelial Intermediate Filaments: Guardians against Microbial Infection?

    Directory of Open Access Journals (Sweden)

    Florian Geisler

    2016-06-01

    Full Text Available Intermediate filaments are abundant cytoskeletal components of epithelial tissues. They have been implicated in overall stress protection. A hitherto poorly investigated area of research is the function of intermediate filaments as a barrier to microbial infection. This review summarizes the accumulating knowledge about this interaction. It first emphasizes the unique spatial organization of the keratin intermediate filament cytoskeleton in different epithelial tissues to protect the organism against microbial insults. We then present examples of direct interaction between viral, bacterial, and parasitic proteins and the intermediate filament system and describe how this affects the microbe-host interaction by modulating the epithelial cytoskeleton, the progression of infection, and host response. These observations not only provide novel insights into the dynamics and function of intermediate filaments but also indicate future avenues to combat microbial infection.

  11. An electro-kinetic study of oxygen reduction in polymer electrolyte fuel cells at intermediate temperatures

    OpenAIRE

    Gatto, I.; Stassi, A.; Passalacqua, E.; Arico, A. S.

    2013-01-01

    International audience; The oxygen reduction process in polymer electrolyte fuel cells (PEMFCs) was in-situ investigated at intermediate temperatures (80 e130 C) by using a carbon supported PtCo catalyst and Nafion membrane as electrolyte. To overcome the Nafion dehydration above 100 C, the experiments were carried out under pressurized conditions. Electro-kinetic parameters such as reaction order and activation energy were determined from the steady-state galvanostatic polarization curves ob...

  12. Effect of Intermediate Hosts on Emerging Zoonoses.

    Science.gov (United States)

    Cui, Jing-An; Chen, Fangyuan; Fan, Shengjie

    2017-08-01

    Most emerging zoonotic pathogens originate from animals. They can directly infect humans through natural reservoirs or indirectly through intermediate hosts. As a bridge, an intermediate host plays different roles in the transmission of zoonotic pathogens. In this study, we present three types of pathogen transmission to evaluate the effect of intermediate hosts on emerging zoonotic diseases in human epidemics. These types are identified as follows: TYPE 1, pathogen transmission without an intermediate host for comparison; TYPE 2, pathogen transmission with an intermediate host as an amplifier; and TYPE 3, pathogen transmission with an intermediate host as a vessel for genetic variation. In addition, we established three mathematical models to elucidate the mechanisms underlying zoonotic disease transmission according to these three types. Stability analysis indicated that the existence of intermediate hosts increased the difficulty of controlling zoonotic diseases because of more difficult conditions to satisfy for the disease to die out. The human epidemic would die out under the following conditions: TYPE 1: [Formula: see text] and [Formula: see text]; TYPE 2: [Formula: see text], [Formula: see text], and [Formula: see text]; and TYPE 3: [Formula: see text], [Formula: see text], [Formula: see text], and [Formula: see text] Simulation with similar parameters demonstrated that intermediate hosts could change the peak time and number of infected humans during a human epidemic; intermediate hosts also exerted different effects on controlling the prevalence of a human epidemic with natural reservoirs in different periods, which is important in addressing problems in public health. Monitoring and controlling the number of natural reservoirs and intermediate hosts at the right time would successfully manage and prevent the prevalence of emerging zoonoses in humans.

  13. Political Competition and Polarization

    DEFF Research Database (Denmark)

    Schultz, Christian

    This paper considers political competition and the consequences of political polarization when parties are better informed about how the economy functions than voters are. Specifically, parties know the cost producing a public good, voters do not. An incumbent's choice of policy acts like a signa...... for costs before an upcoming election. It is shown that the more polarized the political parties the more distorted the incumbent's policy choice.......This paper considers political competition and the consequences of political polarization when parties are better informed about how the economy functions than voters are. Specifically, parties know the cost producing a public good, voters do not. An incumbent's choice of policy acts like a signal...

  14. Physics of polarized targets

    CERN Document Server

    Niinikoski, Tapio

    2014-01-01

    For developing, building and operating solid polarized targets we need to understand several fields of physics that have seen sub stantial advances during the last 50 years. W e shall briefly review a selection of those that are important today. These are: 1) quantum statistical methods to describe saturation and relaxation in magnetic resonance; 2) equal spin temperature model for dy namic nuclear polarization; 3 ) weak saturation during NMR polarization measurement; 4 ) refrigeration using the quantum fluid properties of helium isotopes. These, combined with superconducting magnet technologies, permit today to reach nearly complete pola rization of almost any nuclear spins. Targets can be operated in frozen spin mode in rather low and inhomogeneous field of any orientation, and in DNP mode in beams of high intensity. Beyond such experiments of nuclear and particle physics, applications a re also emerging in macromolecular chemistry and in magnetic resonance imaging. This talk is a tribute to Michel Borghini...

  15. No More Polarization, Please!

    DEFF Research Database (Denmark)

    Hansen, Mia Reinholt

    The organizational science literature on motivation has for long been polarized into two main positions; the organizational economic position focusing on extrinsic motivation and the organizational behavior position emphasizing intrinsic motivation. With the rise of the knowledge economy...... and the increasing levels of complexities it entails, such polarization is not fruitful in the attempt to explain motivation of organizational members. This paper claims that a more nuanced perspective on motivation, acknowledging the co-existence of intrinsic and extrinsic motivation, the possible interaction...... between the two as well as different types of motivations filling in the gap between the two polar types, is urgently needed in the organizational science literature. By drawing on the research on intrinsic and extrinsic motivation conducted in social psychology and combining this with contributions from...

  16. Polarized source upgrading

    International Nuclear Information System (INIS)

    Clegg, T.B.; Rummel, R.L.; Carter, E.P.; Westerfeldt, C.R.; Lovette, A.W.; Edwards, S.E.

    1985-01-01

    The decision was made this past year to move the Lamb-shift polarized ion source which was first installed in the laboratory in 1970. The motivation was the need to improve the flexibility of spin-axis orientation by installing the ion source with a new Wien-filter spin precessor which is capable of rotating physically about the beam axis. The move of the polarized source was accomplished in approximately two months, with the accelerator being turned off for experiments during approximately four weeks of this time. The occasion of the move provided the opportunity to rewire completely the entire polarized ion source frame and to rebuild approximately half of the electronic chassis on the source. The result is an ion source which is now logically wired and carefully documented. Beams obtained from the source are much more stable than those previously available

  17. A lunar polar expedition

    Science.gov (United States)

    Dowling, Richard; Staehle, Robert L.; Svitek, Tomas

    1992-09-01

    Advanced exploration and development in harsh environments require mastery of basic human survival skill. Expeditions into the lethal climates of Earth's polar regions offer useful lessons for tommorrow's lunar pioneers. In Arctic and Antarctic exploration, 'wintering over' was a crucial milestone. The ability to establish a supply base and survive months of polar cold and darkness made extensive travel and exploration possible. Because of the possibility of near-constant solar illumination, the lunar polar regions, unlike Earth's may offer the most hospitable site for habitation. The World Space Foundation is examining a scenario for establishing a five-person expeditionary team on the lunar north pole for one year. This paper is a status report on a point design addressing site selection, transportation, power, and life support requirements.

  18. POLARIZED NEUTRONS IN RHIC

    Energy Technology Data Exchange (ETDEWEB)

    COURANT,E.D.

    1998-04-27

    There does not appear to be any obvious way to accelerate neutrons, polarized or otherwise, to high energies by themselves. To investigate the behavior of polarized neutrons the authors therefore have to obtain them by accelerating them as components of heavier nuclei, and then sorting out the contribution of the neutrons in the analysis of the reactions produced by the heavy ion beams. The best neutron carriers for this purpose are probably {sup 3}He nuclei and deuterons. A polarized deuteron is primarily a combination of a proton and a neutron with their spins pointing in the same direction; in the {sup 3}He nucleus the spins of the two protons are opposite and the net spin (and magnetic moment) is almost the same as that of a free neutron. Polarized ions other than protons may be accelerated, stored and collided in a ring such as RHIC provided the techniques proposed for polarized proton operation can be adapted (or replaced by other strategies) for these ions. To accelerate polarized particles in a ring, one must make provisions for overcoming the depolarizing resonances that occur at certain energies. These resonances arise when the spin tune (ratio of spin precession frequency to orbit frequency) resonates with a component present in the horizontal field. The horizontal field oscillates with the vertical motion of the particles (due to vertical focusing); its frequency spectrum is dominated by the vertical oscillation frequency and its modulation by the periodic structure of the accelerator ring. In addition, the magnet imperfections that distort the closed orbit vertically contain all integral Fourier harmonics of the orbit frequency.

  19. Dark Polar Dunes

    Science.gov (United States)

    2005-01-01

    20 January 2004 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image, acquired during northern summer in December 2004, shows dark, windblown sand dunes in the north polar region of Mars. A vast sea of sand dunes nearly surrounds the north polar cap. These landforms are located near 80.3oN, 144.1oW. Light-toned features in the image are exposures of the substrate that underlies the dune field. The image covers an area about 3 km (1.9 mi) wide and is illuminated by sunlight from the lower left.

  20. Imaging with Polarized Neutrons

    Directory of Open Access Journals (Sweden)

    Nikolay Kardjilov

    2018-01-01

    Full Text Available Owing to their zero charge, neutrons are able to pass through thick layers of matter (typically several centimeters while being sensitive to magnetic fields due to their intrinsic magnetic moment. Therefore, in addition to the conventional attenuation contrast image, the magnetic field inside and around a sample can be visualized by detecting changes of polarization in a transmitted beam. The method is based on the spatially resolved measurement of the cumulative precession angles of a collimated, polarized, monochromatic neutron beam that traverses a magnetic field or sample.

  1. The polar mesosphere

    International Nuclear Information System (INIS)

    Morris, Ray; Murphy, Damian

    2008-01-01

    The mesosphere region, which lies at the edge of space, contains the coldest layer of the Earth's atmosphere, with summer temperatures as low as minus 130 °C. In this extreme environment ice aerosol layers have appeared since the dawn of industrialization—whose existence may arguably be linked to human influence—on yet another layer of the Earth's fragile atmosphere. Ground-based and space-based experiments conducted in the Arctic and Antarctic during the International Polar Year (IPY) aim to address limitations in our knowledge and to advance our understanding of thermal and dynamical processes at play in the polar mesosphere

  2. Internal polarized targets

    Energy Technology Data Exchange (ETDEWEB)

    Kinney, E.R.; Coulter, K.; Gilman, R.; Holt, R.J.; Kowalczyk, R.S.; Napolitano, J.; Potterveld, D.H.; Young, L. (Argonne National Lab., IL (USA)); Mishnev, S.I.; Nikolenko, D.M.; Popov, S.G.; Rachek, I.A.; Temnykh, A.B.; Toporkov, D.K.; Tsentalovich, E.P.; Wojtsekhowski, B.B. (AN SSSR, Novosibirsk (USSR). Inst. Yadernoj Fiziki)

    1989-01-01

    Internal polarized targets offer a number of advantages over external targets. After a brief review of the basic motivation and principles behind internal polarized targets, the technical aspects of the atomic storage cell will be discussed in particular. Sources of depolarization and the means by which their effects can be ameliorated will be described, especially depolarization by the intense magnetic fields arising from the circulating particle beam. The experience of the Argonne Novosibirsk collaboration with the use of a storage cell in a 2 GeV electron storage ring will be the focus of this technical discussion. 17 refs., 11 figs.

  3. AGS polarized H- source

    International Nuclear Information System (INIS)

    Kponou, A.; Alessi, J.G.; Sluyters, T.

    1985-01-01

    The AGS polarized H - source is now operational. During a month-long experimental physics run in July 1984, pulses equivalent to 15 μA x 300 μs (approx. 3 x 10 10 protons) were injected into the RFQ preaccelerator. Beam polarization, measured at 200 MeV, was approx. 75%. After the run, a program to increase the H - yield of the source was begun and significant progress has been made. The H - current is now frequently 20 to 30 μA. A description of the source and some details of our operating experience are given. We also briefly describe the improvement program

  4. Plasticity of intermediate mechanics students’ coordinate system choice

    Directory of Open Access Journals (Sweden)

    Eleanor C. Sayre

    2008-11-01

    Full Text Available We investigate the interplay between mathematics and physics resources in intermediate mechanics students. In the mechanics course, the selection and application of coordinate systems is a consistent thread. At the University of Maine, students often start the course with a strong preference to use Cartesian coordinates, in accordance with their prior physics and mathematics classes. In small-group interviews and in homework help sessions, we ask students to define a coordinate system and set up the equations of motion for a simple pendulum for which polar coordinates are more appropriate. We analyze video data from several encounters using a combination of Process/Object theory and Resource Theory. We find that students sometimes persist in using an inappropriate Cartesian system. Furthermore, students often derive (rather than recall the details of the polar coordinate system, indicating that their knowledge is far from solid. To describe our work more precisely, we define a scale of plasticity and several heuristics for defining resources and their plasticity.

  5. Experimental studies of pion-nucleus interactions at intermediate energies

    International Nuclear Information System (INIS)

    1991-01-01

    This report summarizes the work on experimental research in intermediate energy nuclear physics carried out at New Mexico State University in 1991 under a great from the US Department of Energy. Most of these studies have involved investigations of various pion-nucleus interactions. The work has been carried out both with the LAMPF accelerator at the Los Alamos National Laboratory and with the cyclotron at the Paul Scherrer Institute (PSI) near Zurich, Switzerland. Part of the experimental work involves measurements of new data on double-charge-exchange scattering, using facilities at LAMPF which we helped modify, and on pion absorption, using a new detector system at PSI that covers nearly the full solid-angle region which we helped construct. Other work involved preparation for future experiments using polarized nuclear targets and a new high-resolution spectrometer system for detecting π 0 mesons. We also presented several proposals for works to be done in future years, involving studies related to pi-mesonic atoms, fundamental pion-nucleon interactions, studies of the difference between charged and neutral pion interactions with the nucleon, studies of the isospin structure of pion-nucleus interactions, and pion scattering from polarized 3 He targets. This work is aimed at improving our understanding of the pion-nucleon interaction, of the pion-nucleus interaction mechanism, and of nuclear structure

  6. The physics of polarization

    Science.gov (United States)

    Landi Degl'Innocenti, Egidio

    This course is intended to give a description of the basic physical concepts which underlie the study and the interpretation of polarization phenomena. Apart from a brief historical introduction (Sect. 1), the course is organized in three parts. A first part (Sects. 2 - 6) covers the most relevant facts about the polarization phenomena that are typically encountered in laboratory applications and in everyday life. In Sect. 2, the modern description of polarization in terms of the Stokes parameters is recalled, whereas Sect. 3 is devoted to introduce the basic tools of laboratory polarimetry, such as the Jones calculus and the Mueller matrices. The polarization phenomena which are met in the reflection and refraction of a beam of radiation at the separation surface between two dielectrics, or between a dielectric and a metal, are recalled in Sect. 4. Finally, Sect. 5 gives an introduction to the phenomena of dichroism and of anomalous dispersion and Sect. 6 summarizes the polarization phenomena that are commonly encountered in everyday life. The second part of this course (Sects. 7-14) deals with the description, within the formalism of classical physics, of the spectro-polarimetric properties of the radiation emitted by accelerated charges. Such properties are derived by taking as starting point the Liénard and Wiechert equations that are recalled and discussed in Sect. 7 both in the general case and in the non-relativistic approximation. The results are developed to find the percentage polarization, the radiation diagram, the cross-section and the spectral characteristics of the radiation emitted in different phenomena particularly relevant from the astrophysical point of view. The emission of a linear antenna is derived in Sect. 8. The other Sections are devoted to Thomson scattering (Sect. 9), Rayleigh scattering (Sect. 10), Mie scattering (Sect. 11), bremsstrahlung radiation (Sect. 12), cyclotron radiation (Sect. 13), and synchrotron radiation (Sect. 14

  7. Polarized Proton Collisions at RHIC

    CERN Document Server

    Bai, Mei; Alekseev, Igor G; Alessi, James; Beebe-Wang, Joanne; Blaskiewicz, Michael; Bravar, Alessandro; Brennan, Joseph M; Bruno, Donald; Bunce, Gerry; Butler, John J; Cameron, Peter; Connolly, Roger; De Long, Joseph; Drees, Angelika; Fischer, Wolfram; Ganetis, George; Gardner, Chris J; Glenn, Joseph; Hayes, Thomas; Hseuh Hsiao Chaun; Huang, Haixin; Ingrassia, Peter; Iriso, Ubaldo; Laster, Jonathan S; Lee, Roger C; Luccio, Alfredo U; Luo, Yun; MacKay, William W; Makdisi, Yousef; Marr, Gregory J; Marusic, Al; McIntyre, Gary; Michnoff, Robert; Montag, Christoph; Morris, John; Nicoletti, Tony; Oddo, Peter; Oerter, Brian; Osamu, Jinnouchi; Pilat, Fulvia Caterina; Ptitsyn, Vadim; Roser, Thomas; Satogata, Todd; Smith, Kevin T; Svirida, Dima; Tepikian, Steven; Tomas, Rogelio; Trbojevic, Dejan; Tsoupas, Nicholaos; Tuozzolo, Joseph; Vetter, Kurt; Wilinski, Michelle; Zaltsman, Alex; Zelenski, Anatoli; Zeno, Keith; Zhang, S Y

    2005-01-01

    The Relativistic Heavy Ion Collider~(RHIC) provides not only collisions of ions but also collisions of polarized protons. In a circular accelerator, the polarization of polarized proton beam can be partially or fully lost when a spin depolarizing resonance is encountered. To preserve the beam polarization during acceleration, two full Siberian snakes were employed in RHIC to avoid depolarizing resonances. In 2003, polarized proton beams were accelerated to 100~GeV and collided in RHIC. Beams were brought into collisions with longitudinal polarization at the experiments STAR and PHENIX by using spin rotators. RHIC polarized proton run experience demonstrates that optimizing polarization transmission efficiency and improving luminosity performance are significant challenges. Currently, the luminosity lifetime in RHIC is limited by the beam-beam effect. The current state of RHIC polarized proton program, including its dedicated physics run in 2005 and efforts to optimize luminosity production in beam-beam limite...

  8. Role of competition between polarity sites in establishing a unique front

    Science.gov (United States)

    Wu, Chi-Fang; Chiou, Jian-Geng; Minakova, Maria; Woods, Benjamin; Tsygankov, Denis; Zyla, Trevin R; Savage, Natasha S; Elston, Timothy C; Lew, Daniel J

    2015-01-01

    Polarity establishment in many cells is thought to occur via positive feedback that reinforces even tiny asymmetries in polarity protein distribution. Cdc42 and related GTPases are activated and accumulate in a patch of the cortex that defines the front of the cell. Positive feedback enables spontaneous polarization triggered by stochastic fluctuations, but as such fluctuations can occur at multiple locations, how do cells ensure that they make only one front? In polarizing cells of the model yeast Saccharomyces cerevisiae, positive feedback can trigger growth of several Cdc42 clusters at the same time, but this multi-cluster stage rapidly evolves to a single-cluster state, which then promotes bud emergence. By manipulating polarity protein dynamics, we show that resolution of multi-cluster intermediates occurs through a greedy competition between clusters to recruit and retain polarity proteins from a shared intracellular pool. DOI: http://dx.doi.org/10.7554/eLife.11611.001 PMID:26523396

  9. Language in use intermediate : classroom book

    CERN Document Server

    Doff, Adrian

    1995-01-01

    ach of the four levels comprises about 80 hours of class work, with additional time for the self-study work. The Teacher's Book contains all the pages from the Classroom Book, with interleaved teaching notes including optional activities to cater for different abilities. There is a video to accompany the Beginner, Pre-intermediate and Intermediate levels. Each video contains eight stimulating and entertaining short programmes, as well as a booklet of photocopiable activities. Free test material is available in booklet and web format for Beginner and Pre-intermediate levels. Visit www.cambridge.org/elt/liu or contact your local Cambridge University Press representative.

  10. Language in use intermediate : teacher's book

    CERN Document Server

    Doff, Adrian

    1998-01-01

    Each of the four levels comprises about 80 hours of class work, with additional time for the self-study work. The Teacher's Book contains all the pages from the Classroom Book, with interleaved teaching notes including optional activities to cater for different abilities. There is a video to accompany the Beginner, Pre-intermediate and Intermediate levels. Each video contains eight stimulating and entertaining short programmes, as well as a booklet of photocopiable activities. Free test material is available in booklet and web format for Beginner and Pre-intermediate levels. Visit www.cambridge.org/elt/liu or contact your local Cambridge University Press representative.

  11. Intermedial Strategies of Memory in Contemporary Novels

    DEFF Research Database (Denmark)

    Tanderup, Sara

    2014-01-01

    , and Judd Morrissey and drawing on the theoretical perspectives of N. Katherine Hayles (media studies) and Andreas Huyssen (cultural memory studies), Tanderup argues that recent intermedial novels reflect a certain nostalgia celebrating and remembering the book as a visual and material object in the age......In her article "Intermedial Strategies and Memory in Contemporary Novels" Sara Tanderup discusses a tendency in contemporary literature towards combining intermedial experiments with a thematic preoccupation with memory and trauma. Analyzing selected works by Steven Hall, Jonathan Safran Foer...... of digital media while also highlighting the influence of new media on our cultural understanding and representation of memory and the past....

  12. Lobbying and political polarization

    OpenAIRE

    Ursprung, Heinrich W.

    2002-01-01

    Standard spatial models of political competition give rise to equilibria in which the competing political parties or candidates converge to a common position. In this paper I show how political polarization can be generated in models that focus on the nexus between pre-election interest group lobbying and electoral competition.

  13. Fluorescence confocal polarizing microscopy

    Indian Academy of Sciences (India)

    Much of the modern understanding of orientational order in liquid crystals (LCs) is based on polarizing microscopy (PM). A PM image bears only two-dimensional (2D) information, integrating the 3D pattern of optical birefringence over the path of light. Recently, we proposed a technique to image 3D director patterns by ...

  14. Polarization of Bremsstrahlung

    International Nuclear Information System (INIS)

    Miller, J.

    1957-01-01

    The numerical results for the polarization of Bremsstrahlung are presented. The multiple scattering of electrons in the target is taken into account. The angular-and photon energy dependences are seen on the curves for an incident 25 MeV electron energy. (Author) [fr

  15. DESY: HERA polarization

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    The new HERA electron-proton collider at DESY in Hamburg achieved the first luminosity for electron-proton collisions on 19 October last year. Only one month later, on 20 November, HERA passed another important milestone with the observation of transverse electron polarization

  16. Titan Polar Landscape Evolution

    Science.gov (United States)

    Moore, Jeffrey M.

    2016-01-01

    With the ongoing Cassini-era observations and studies of Titan it is clear that the intensity and distribution of surface processes (particularly fluvial erosion by methane and Aeolian transport) has changed through time. Currently however, alternate hypotheses substantially differ among specific scenarios with respect to the effects of atmospheric evolution, seasonal changes, and endogenic processes. We have studied the evolution of Titan's polar region through a combination of analysis of imaging, elevation data, and geomorphic mapping, spatially explicit simulations of landform evolution, and quantitative comparison of the simulated landscapes with corresponding Titan morphology. We have quantitatively evaluated alternate scenarios for the landform evolution of Titan's polar terrain. The investigations have been guided by recent geomorphic mapping and topographic characterization of the polar regions that are used to frame hypotheses of process interactions, which have been evaluated using simulation modeling. Topographic information about Titan's polar region is be based on SAR-Topography and altimetry archived on PDS, SAR-based stereo radar-grammetry, radar-sounding lake depth measurements, and superposition relationships between geomorphologic map units, which we will use to create a generalized topographic map.

  17. Graphics of polar figure

    International Nuclear Information System (INIS)

    Macias B, L.R.

    1991-11-01

    The objective of this work, is that starting from a data file coming from a spectra that has been softened, and of the one that have been generated its coordinates to project it in stereographic form, to create the corresponding polar figure making use of the Cyber computer of the ININ by means of the GRAPHOS package. This work only requires a Beta, Fi and Intensity (I) enter data file. It starts of the existence of a softened spectra of which have been generated already with these data, making use of some language that in this case was FORTRAN for the Cyber computer, a program is generated supported in the Graphos package that allows starting of a reading of the Beta, Fi, I file, to generate the points in a stereographic projection and that it culminates with the graph of the corresponding polar figure. The program will request the pertinent information that is wanted to capture in the polar figure just as: date, name of the enter file, indexes of the polar figure, number of levels, radio of the stereographic projection (cms.), crystalline system to which belongs the sample, name the neuter graph file by create and to add the own general data. (Author)

  18. Characteristics of volume polarization holography with linear polarization light

    Science.gov (United States)

    Zang, Jinliang; Wu, An'an; Liu, Ying; Wang, Jue; Lin, Xiao; Tan, Xiaodi; Shimura, Tsutomu; Kuroda, Kazuo

    2015-10-01

    Volume polarization holographic recording in phenanthrenequinone-doped poly(methyl methacrylate) (PQ-PMMA) photopolymer with linear polarized light is obtained. The characteristics of the volume polarization hologram are experimentally investigated. It is found that beyond the paraxial approximation the polarization states of the holographic reconstruction light are generally different from the signal light. Based on vector wave theoretical analyses and material properties, the special exposure condition for correctly holographic reconstruction is obtained and experimentally demonstrated.

  19. Polarization dependent switching of asymmetric nanorings with a circular field

    Directory of Open Access Journals (Sweden)

    Nihar R. Pradhan

    2016-01-01

    Full Text Available We experimentally investigated the switching from onion to vortex states in asymmetric cobalt nanorings by an applied circular field. An in-plane field is applied along the symmetric or asymmetric axis of the ring to establish domain walls (DWs with symmetric or asymmetric polarization. A circular field is then applied to switch from the onion state to the vortex state, moving the DWs in the process. The asymmetry of the ring leads to different switching fields depending on the location of the DWs and direction of applied field. For polarization along the asymmetric axis, the field required to move the DWs to the narrow side of the ring is smaller than the field required to move the DWs to the larger side of the ring. For polarization along the symmetric axis, establishing one DW in the narrow side and one on the wide side, the field required to switch to the vortex state is an intermediate value.

  20. Intermediate/Advanced Research Design and Statistics

    Science.gov (United States)

    Ploutz-Snyder, Robert

    2009-01-01

    The purpose of this module is To provide Institutional Researchers (IRs) with an understanding of the principles of advanced research design and the intermediate/advanced statistical procedures consistent with such designs

  1. The deterioration of intermediate moisture foods

    Science.gov (United States)

    Labruza, T. P.

    1971-01-01

    Deteriorative reactions are low and food quality high if intermediate moisture content of a food is held at a water activity of 0.6 to 0.75. Information is of interest to food processing and packaging industry.

  2. Proposed changes in intermediate pipe break criteria

    International Nuclear Information System (INIS)

    Schmitz, R.P.

    1984-01-01

    Bechtel Power Corporation proposed to the US NRC in 1983 that the NRC eliminate from their criteria all intermediate breaks. Bechtel's rationale for the proposal and support for their position are presented

  3. MNE Entrepreneurial Capabilities at Intermediate Levels

    DEFF Research Database (Denmark)

    Hoenen, Anne K.; Nell, Phillip Christopher; Ambos, Björn

    2014-01-01

    at intermediate geographical levels differ from local subsidiaries and global corporate headquarters, and why those differences are important. We illustrate our arguments using data on European regional headquarters (RHQs). We find that RHQs' entrepreneurial capabilities depend on their external embeddedness...

  4. Directional spread parameter at intermediate water depth

    Digital Repository Service at National Institute of Oceanography (India)

    SanilKumar, V.; Deo, M.C.; Anand, N.M.; AshokKumar, K.

    The characteristics of directional spread parameters at intermediate water depth are investigated based on a cosine power '2s' directional spreading model. This is based on wave measurements carried out using a Datawell directional waverider buoy...

  5. Experiments with Fermilab polarized proton and polarized antiproton beams

    International Nuclear Information System (INIS)

    Yokosawa, A.

    1990-01-01

    We summarize activities concerning the Fermilab polarized beams. They include a brief description of the polarized-beam facility, measurements of beam polarization by polarimeters, asymmetry measurements in the π degree production at high p perpendicular and in the Λ (Σ degree), π ± , π degree production at large x F , and Δσ L (pp, bar pp) measurements. 18 refs

  6. NUCLEON POLARIZATION IN 3-BODY MODELS OF POLARIZED LI-6

    NARCIS (Netherlands)

    SCHELLINGERHOUT, NW; KOK, LP; COON, SA; ADAM, RM

    1993-01-01

    Just as He-3 --> can be approximately characterized as a polarized neutron target, polarized Li-6D has been advocated as a good isoscalar nuclear target for the extraction of the polarized gluon content of the nucleon. The original argument rests upon a presumed ''alpha + deuteron'' picture of Li-6,

  7. The keratin-binding protein Albatross regulates polarization of epithelial cells

    OpenAIRE

    Sugimoto, Masahiko; Inoko, Akihito; Shiromizu, Takashi; Nakayama, Masanori; Zou, Peng; Yonemura, Shigenobu; Hayashi, Yuko; Izawa, Ichiro; Sasoh, Mikio; Uji, Yukitaka; Kaibuchi, Kozo; Kiyono, Tohru; Inagaki, Masaki

    2008-01-01

    The keratin intermediate filament network is abundant in epithelial cells, but its function in the establishment and maintenance of cell polarity is unclear. Here, we show that Albatross complexes with Par3 to regulate formation of the apical junctional complex (AJC) and maintain lateral membrane identity. In nonpolarized epithelial cells, Albatross localizes with keratin filaments, whereas in polarized epithelial cells, Albatross is primarily localized in the vicinity of the AJC. Knockdown o...

  8. Intermediality, Architecture, and the Politics of Urbanity

    OpenAIRE

    Tortosa Garrigós, Virgilio

    2011-01-01

    In his article "Intermediality, Architecture, and the Politics of Urbanity" Virgilio Tortosa Garrigós discusses aspects of the exponential development of large cities, the neoliberal economy, and the "spectacle" of architecture in the context of intermediality. With the connivance between land speculators and politicians — which has led not only to the loss of spatial identity but to irreversible pollution and geographic degradation — urbanity is epitomized on the Mediterranean coast line. In...

  9. Intermediate Inflation or Late Time Acceleration?

    International Nuclear Information System (INIS)

    Sanyal, A.K.

    2008-01-01

    The expansion rate of intermediate inflation lies between the exponential and power law expansion but corresponding accelerated expansion does not start at the onset of cosmological evolution. Present study of intermediate inflation reveals that it admits scaling solution and has got a natural exit form it at a later epoch of cosmic evolution, leading to late time acceleration. The corresponding scalar field responsible for such feature is also found to behave as a tracker field for gravity with canonical kinetic term.

  10. Geomagnetic polarity transitions

    Science.gov (United States)

    Merrill, Ronald T.; McFadden, Phillip L.

    1999-05-01

    The top of Earth's liquid outer core is nearly 2900 km beneath Earth's surface, so we will never be able to observe it directly. This hot, dense, molten iron-rich body is continuously in motion and is the source of Earth's magnetic field. One of the most dynamic manifestations at Earth's surface of this fluid body is, perhaps, a reversal of the geomagnetic field. Unfortunately, the most recent polarity transition occurred at about 780 ka, so we have never observed a transition directly. It seems that a polarity transition spans many human lifetimes, so no human will ever witness the phenomenon in its entirety. Thus we are left with the tantalizing prospect that paleomagnetic records of polarity transitions may betray some of the secrets of the deep Earth. Certainly, if there are systematics in the reversal process and they can be documented, then this will reveal substantial information about the nature of the lowermost mantle and of the outer core. Despite their slowness on a human timescale, polarity transitions occur almost instantaneously on a geological timescale. This rapidity, together with limitations in the paleomagnetic recording process, prohibits a comprehensive description of any reversal transition both now and into the foreseeable future, which limits the questions that may at this stage be sensibly asked. The natural model for the geomagnetic field is a set of spherical harmonic components, and we are not able to obtain a reliable model for even the first few harmonic terms during a transition. Nevertheless, it is possible, in principle, to make statements about the harmonic character of a geomagnetic polarity transition without having a rigorous spherical harmonic description of one. For example, harmonic descriptions of recent geomagnetic polarity transitions that are purely zonal can be ruled out (a zonal harmonic does not change along a line of latitude). Gleaning information about transitions has proven to be difficult, but it does seem

  11. Higher order antibunching in intermediate states

    International Nuclear Information System (INIS)

    Verma, Amit; Sharma, Navneet K.; Pathak, Anirban

    2008-01-01

    Since the introduction of binomial state as an intermediate state, different intermediate states have been proposed. Different nonclassical effects have also been reported in these intermediate states. But till now higher order antibunching is predicted in only one type of intermediate state, which is known as shadowed negative binomial state. Recently we have shown that the higher order antibunching is not a rare phenomenon [P. Gupta, P. Pandey, A. Pathak, J. Phys. B 39 (2006) 1137]. To establish our earlier claim further, here we have shown that the higher order antibunching can be seen in different intermediate states, such as binomial state, reciprocal binomial state, hypergeometric state, generalized binomial state, negative binomial state and photon added coherent state. We have studied the possibility of observing the higher order subpoissonian photon statistics in different limits of intermediate states. The effects of different control parameters on the depth of non classicality have also been studied in this connection and it has been shown that the depth of nonclassicality can be tuned by controlling various physical parameters

  12. Associations of Systemic Diseases with Intermediate Uveitis.

    Science.gov (United States)

    Shoughy, Samir S; Kozak, Igor; Tabbara, Khalid F

    2016-01-01

    To determine the associations of systemic diseases with intermediate uveitis. The medical records of 50 consecutive cases with intermediate uveitis referred to The Eye Center in Riyadh, Saudi Arabia, were reviewed. Age- and sex-matched patients without uveitis served as controls. Patients had complete ophthalmic and medical examinations. There were 27 male and 23 female patients. Mean age was 29 years with a range of 5-62 years. Overall, 21 cases (42%) had systemic disorders associated with intermediate uveitis and 29 cases (58%) had no associated systemic disease. A total of 11 patients (22%) had asthma, 4 (8%) had multiple sclerosis, 3 (6%) had presumed ocular tuberculosis, 1 (2%) had inflammatory bowel disease, 1 (2%) had non-Hodgkin lymphoma and 1 (2%) had sarcoidosis. Evidence of systemic disease was found in 50 (5%) of the 1,000 control subjects. Bronchial asthma was found in 37 patients (3.7 %), multiple sclerosis in 9 patients (0.9%), inflammatory bowel disease in 3 patients (0.3%), and tuberculosis in 1 patient (0.1%). None of the control patients had sarcoidosis or lymphoma. There were statistically significant associations between intermediate uveitis and bronchial asthma (p = 0.0001), multiple sclerosis (p = 0.003) and tuberculosis (p = 0.0005). Bronchial asthma and multiple sclerosis were the most frequently encountered systemic diseases associated with intermediate uveitis in our patient population. Patients with intermediate uveitis should undergo careful history-taking and investigations to rule out associated systemic illness.

  13. Polarized electron beams at SLAC

    International Nuclear Information System (INIS)

    Moffeit, K.C.

    1992-11-01

    SLAC has successfully accelerated high energy polarized electrons for the Stanford Linear Collider and fixed polarized nuclear target experiments. The polarized electron beams at SLAC use a gallium arsenide (GaAlAs for E-142) photon emission source to provide the beam of polarized electrons with polarization of approximately 28% (41% for E-142). While the beam emittance is reduced in the damping ring for SLC operation a system of bend magnets and superconducting solenoids preserve and orient the spin direction for maximum longitudinal polarization at the collision point. The electron polarization is monitored with a Compton scattering polarimeter, and was typically 22% at the e+e- collision point for the 1992 run. Improvements are discussed to increase the source polarization and to reduce the depolarization effects between the source and the collision point

  14. Analytical polarization calculations beyond SLIM

    International Nuclear Information System (INIS)

    Barber, D.P.

    1989-01-01

    A comparison is made between the theories of Bell and Leinaas and of Derbenev and Kondratenko for the spin polarization in electron storage rings. A calculation of polarization in HERA using the program SMILE of Mane is presented

  15. On Determinants of Political Polarization

    OpenAIRE

    Grechyna, Daryna

    2015-01-01

    Political polarization has been shown to significantly influence a country's economic performance. However, little is known about the drivers of political polarization. In this article, we aim to identify the main determinants of political polarization using Bayesian Model Averaging to overcome the problem of model uncertainty. We find that the level of trust within a country and the degree of income inequality are the most robust determinants of political polarization.

  16. Polarized electrogowdy spacetimes censored

    Energy Technology Data Exchange (ETDEWEB)

    Nungesser, Ernesto, E-mail: ernesto.nungesser@aei.mpg.d [Max-Planck-Institut fuer Gravitationsphysik, Albert-Einstein-Institut, Am Muehlenberg 1, 14476 Potsdam (Germany)

    2010-05-01

    A sketch of the proof of strong cosmic censorship is presented for a class of solutions of the Einstein-Maxwell equations, those with polarized Gowdy symmetry. A key element of the argument is the observation that by means of a suitable choice of variables the central equations in this problem can be written in a form where they are identical to the central equations for general (i.e. non-polarized) vacuum Gowdy spacetimes. Using this it is seen that the results of Ringstroem on strong cosmic censorship in the vacuum case have implications for the Einstein-Maxwell case. Working out the geometrical meaning of these analytical results leads to the main conclusion.

  17. Ultraviolet, optical, and infrared observations of the intermediate polar TV Columbae

    Science.gov (United States)

    Mateo, M.; Szkody, P.; Hutchings, J.

    1985-01-01

    Forty-three IUE spectra of the X-ray discovered, triply periodic cataclysmic variable, TV Col are examined. The results show that the UV flux varies with the four-day period discovered by Motch in 1981. By fitting continuum models to the UV and optical fluxes, it is inferred that this modulation corresponds to the periodic heating of a normally 9000 K source within the binary system due to reprocessing of beamed X-ray and (possibly) EUV radiation from the vicinity of the degenerate star. The observed flux from this heated source is consistent with its origin at either the disk hot spot or the secondary star. Phasing arguments, however, favor the identification of the latter as the primary reprocessing site in the system. The infrared observations are not consistent with the model proposed by Watts et al. in 1982 and imply that the four-day period does not correspond to the orbital period of the binary.

  18. Frizzled3 controls axonal polarity and intermediate target entry during striatal pathway development

    NARCIS (Netherlands)

    Morello, Francesca; Prasad, Asheeta A.; Rehberg, Kati; Baptista Vieira de Sá, Renata; Antón-Bolaños, Noelia; Leyva-Diaz, Eduardo; Adolfs, Youri; Tissir, Fadel; López-Bendito, Guillermina; Pasterkamp, R. Jeroen

    2015-01-01

    The striatum is a large brain nucleus with an important role in the control of movement and emotions.Mediumspiny neurons (MSNs) are striatal output neurons forming prominent descending axon tracts that target different brain nuclei. However, how MSN axon tracts in the forebrain develop remains

  19. Evidence for Intermediate Polars as the Origin of the Galactic Center Hard X-ray Emission

    DEFF Research Database (Denmark)

    Hailey, Charles J.; Mori, Kaya; Perez, Kerstin

    2016-01-01

    estimated white dwarf mass. Observations of the inner 10 pc can be accounted for by IPs with 〈MWD〉≈0.9M⊙, consistent with that of the CV population in general and the X-ray observed field IPs in particular. The lower mass derived by Chandra and XMM-Newton appears to be an artifact of narrow energy...

  20. XSS J0056+4548 : a hard X-ray intermediate polar in the period gap

    Science.gov (United States)

    Bonnet-Bidaud, J. M.; de Martino, D.; Mouchet, M.

    2009-01-01

    We report on a preliminary analysis of the XMM observations of the suspected cataclysmic variable XSS0056 performed on Dec. 31, 2007 (Start time : 2007-12-31T04:33:32.000) for a total of 16 ksec (Observation ID: 0501230301). The source is detected in the EPIC-pn camera at an average net countrate of 2.7 cts/sec. A Scargle periodogram reveals a strong peak at about 184 cycles/day (with its first harmonic at a power ratio of 10) as well as a low frequency peak around 9.4 cycles/day.

  1. Formation of intermediate products during the resonance stepwise polarization of dibenzyl ketone and benzil molecules

    International Nuclear Information System (INIS)

    Polevoi, A.V.; Matyuk, V.M.; Grigor'eva, G.A.; Potapov, V.K.

    1987-01-01

    The processes resulting in the intramolecular redistribution of energy in electronically excited S/sub ππ*/ states of dibenzyl ketone and benzil molecules have been investigated by laser mass spectrometry. The decisive role of dissociation under the conditions of the resonance stepwise photoionization of these molecules upon excitation by radiation with λ = 266 nm has been demonstrated. The ionization potentials of the molecules and the appearance potentials of fragment ions from dibenzyl ketone and benzil have been determined on the basis of an analysis of photoionization efficiency curves

  2. PEPPo: Using a Polarized Electron Beam to Produce Polarized Positrons

    Energy Technology Data Exchange (ETDEWEB)

    Adeyemi, Adeleke H. [Hampton Univ., Hampton, VA (United States); et al.

    2015-09-01

    Polarized positron beams have been identified as either an essential or a significant ingredient for the experimental program of both the present and next generation of lepton accelerators (JLab, Super KEK B, ILC, CLIC). An experiment demonstrating a new method for producing polarized positrons has been performed at the Continuous Electron Beam Accelerator Facility at Jefferson Lab. The PEPPo (Polarized Electrons for Polarized Positrons) concept relies on the production of polarized e⁻/e⁺ pairs from the bremsstrahlung radiation of a longitudinally polarized electron beam interacting within a high-Z conversion target. PEPPo demonstrated the effective transfer of spin-polarization of an 8.2 MeV/c polarized (P~85%) electron beam to positrons produced in varying thickness tungsten production targets, and collected and measured in the range of 3.1 to 6.2 MeV/c. In comparison to other methods this technique reveals a new pathway for producing either high-energy or thermal polarized positron beams using a relatively low polarized electron beam energy (~10MeV) .This presentation will describe the PEPPo concept, the motivations of the experiment and high positron polarization achieved.

  3. Polarization induced doped transistor

    Science.gov (United States)

    Xing, Huili; Jena, Debdeep; Nomoto, Kazuki; Song, Bo; Zhu, Mingda; Hu, Zongyang

    2016-06-07

    A nitride-based field effect transistor (FET) comprises a compositionally graded and polarization induced doped p-layer underlying at least one gate contact and a compositionally graded and doped n-channel underlying a source contact. The n-channel is converted from the p-layer to the n-channel by ion implantation, a buffer underlies the doped p-layer and the n-channel, and a drain underlies the buffer.

  4. Polar bears, Ursus maritimus

    Science.gov (United States)

    Rode, Karyn D.; Stirling, Ian

    2017-01-01

    Polar bears are the largest of the eight species of bears found worldwide and are covered in a pigment-free fur giving them the appearance of being white. They are the most carnivorous of bear species consuming a high-fat diet, primarily of ice-associated seals and other marine mammals. They range throughout the circumpolar Arctic to the southernmost extent of seasonal pack ice.

  5. Polarized advanced fuel reactors

    International Nuclear Information System (INIS)

    Kulsrud, R.M.

    1987-07-01

    The d- 3 He reaction has the same spin dependence as the d-t reaction. It produces no neutrons, so that if the d-d reactivity could be reduced, it would lead to a neutron-lean reactor. The current understanding of the possible suppression of the d-d reactivity by spin polarization is discussed. The question as to whether a suppression is possible is still unresolved. Other advanced fuel reactions are briefly discussed. 11 refs

  6. On polarization in biomembranes

    DEFF Research Database (Denmark)

    Zecchi, Karis Amata

    close to physiological conditions, making these effects biologically relevant. In this work, we consider the case of asymmetric membranes which can display spontaneous polarization in the absence of a field. Close to the phase transition, we find that the membrane displays piezoelectric, flexoelectric...... on different geometries point in the direction of a flexoelectric mechanism behind current rectification in lipid bilayers. Finally, we suggest that our updated equivalent circuit should be included in the interpretation of elctrophysiological data....

  7. Multifrequency Behaviour of Polars

    Directory of Open Access Journals (Sweden)

    K. Reinsch

    2015-02-01

    Full Text Available Cataclysmic variables emit over a wide range of the electromagnetic spectrum. In this paper I will review observations of polars in relevant passbands obtained during the last decade and will discuss their diagnostical potential to access the physics of the main components within the binary systems. This will include a discussion of intrinsic source variability and the quest for simultaneous multi-frequency observations.

  8. Polar Business Design

    Directory of Open Access Journals (Sweden)

    Sébastien Caisse

    2014-02-01

    Full Text Available Polar business design aims to enable entrepreneurs, managers, consultants, researchers, and business students to better tackle model-based analysis, creation, and transformation of businesses, ventures, and, more generically, collective endeavors of any size and purpose. It is based on a systems-thinking approach that builds on a few interrelated core concepts to create holistic visual frameworks. These core concepts act as poles linked by meaningful dyads, flows, and faces arranged in geometric shapes. The article presents two such polar frameworks as key findings in an ongoing analytic autoethnography: the three-pole Value−Activity−Stakeholder (VAS triquetra and the four-pole Offer−Creation−Character−Stakeholder (OCCS tetrahedron. The VAS triquetra is a more aggregated model of collective endeavors. The OCCS tetrahedron makes a trade-off between a steeper learning curve and deeper, richer representation potential. This article discusses how to use these two frameworks as well as their limits, and explores the potential that polar business design offers for future research.

  9. Partially folded intermediates during trypsinogen denaturation

    Directory of Open Access Journals (Sweden)

    Martins N.F.

    1999-01-01

    Full Text Available The equilibrium unfolding of bovine trypsinogen was studied by circular dichroism, differential spectra and size exclusion HPLC. The change in free energy of denaturation was = 6.99 ± 1.40 kcal/mol for guanidine hydrochloride and = 6.37 ± 0.57 kcal/mol for urea. Satisfactory fits of equilibrium unfolding transitions required a three-state model involving an intermediate in addition to the native and unfolded forms. Size exclusion HPLC allowed the detection of an intermediate population of trypsinogen whose Stokes radii varied from 24.1 ± 0.4 Å to 26.0 ± 0.3 Å for 1.5 M and 2.5 M guanidine hydrochloride, respectively. During urea denaturation, the range of Stokes radii varied from 23.9 ± 0.3 Å to 25.7 ± 0.6 Å for 4.0 M and 6.0 M urea, respectively. Maximal intrinsic fluorescence was observed at about 3.8 M urea with 8-aniline-1-naphthalene sulfonate (ANS binding. These experimental data indicate that the unfolding of bovine trypsinogen is not a simple transition and suggest that the equilibrium intermediate population comprises one intermediate that may be characterized as a molten globule. To obtain further insight by studying intermediates representing different stages of unfolding, we hope to gain a better understanding of the complex interrelations between protein conformation and energetics.

  10. Modelling Near-IR polarization to constrain stellar wind bow shocks

    Science.gov (United States)

    Neilson, Hilding R.; Ignace, R.; Shrestha, M.; Hoffman, J. L.; Mackey, J.

    2013-06-01

    Bow shocks formed from stellar winds are common phenomena observed about massive and intermediate-mass stars such as zeta Oph, Betelgeuse and delta Cep. These bow shocks provide information about the motion of the star, the stellar wind properties and the density of the ISM. Because bow shocks are asymmetric structures, they also present polarized light that is a function of their shape and density. We present a preliminary work modeling dust polarization from a Wilkin (1996) analytic bow shock model and explore how the polarization changes as a function of stellar wind properties.

  11. Spin dependent fragmentation functions for heavy flavor baryons and single heavy hyperon polarization

    CERN Document Server

    Goldstein, G R

    2001-01-01

    Spin dependent fragmentation functions for heavy flavor quarks to fragment into heavy baryons are calculated in a quark-diquark model. The production of intermediate spin 1/2 and 3/2 excited states is explicity included. $\\Lambda_b$ , $\\Lambda_c$ and $\\Xi_c$ production rate and polarization at LEP energies are calculated and, where possible, compared with experiment. A different approach, also relying on a heavy quark-diquark model, is proposed for the small momentum transfer inclusive production of polarized heavy flavor hyperons. The predicted $\\Lambda_c$ polarization is roughly in agreement with experiment.

  12. The ARES High-level Intermediate Representation

    Energy Technology Data Exchange (ETDEWEB)

    Moss, Nicholas David [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-03-03

    The LLVM intermediate representation (IR) lacks semantic constructs for depicting common high-performance operations such as parallel and concurrent execution, communication and synchronization. Currently, representing such semantics in LLVM requires either extending the intermediate form (a signi cant undertaking) or the use of ad hoc indirect means such as encoding them as intrinsics and/or the use of metadata constructs. In this paper we discuss a work in progress to explore the design and implementation of a new compilation stage and associated high-level intermediate form that is placed between the abstract syntax tree and when it is lowered to LLVM's IR. This highlevel representation is a superset of LLVM IR and supports the direct representation of these common parallel computing constructs along with the infrastructure for supporting analysis and transformation passes on this representation.

  13. Intermediate-energy nuclear chemistry workshop

    Energy Technology Data Exchange (ETDEWEB)

    Butler, G.W.; Giesler, G.C.; Liu, L.C.; Dropesky, B.J.; Knight, J.D.; Lucero, F.; Orth, C.J.

    1981-05-01

    This report contains the proceedings of the LAMPF Intermediate-Energy Nuclear Chemistry Workshop held in Los Alamos, New Mexico, June 23-27, 1980. The first two days of the Workshop were devoted to invited review talks highlighting current experimental and theoretical research activities in intermediate-energy nuclear chemistry and physics. Working panels representing major topic areas carried out indepth appraisals of present research and formulated recommendations for future research directions. The major topic areas were Pion-Nucleus Reactions, Nucleon-Nucleus Reactions and Nuclei Far from Stability, Mesonic Atoms, Exotic Interactions, New Theoretical Approaches, and New Experimental Techniques and New Nuclear Chemistry Facilities.

  14. Intermediate-energy nuclear chemistry workshop

    International Nuclear Information System (INIS)

    Butler, G.W.; Giesler, G.C.; Liu, L.C.; Dropesky, B.J.; Knight, J.D.; Lucero, F.; Orth, C.J.

    1981-05-01

    This report contains the proceedings of the LAMPF Intermediate-Energy Nuclear Chemistry Workshop held in Los Alamos, New Mexico, June 23-27, 1980. The first two days of the Workshop were devoted to invited review talks highlighting current experimental and theoretical research activities in intermediate-energy nuclear chemistry and physics. Working panels representing major topic areas carried out indepth appraisals of present research and formulated recommendations for future research directions. The major topic areas were Pion-Nucleus Reactions, Nucleon-Nucleus Reactions and Nuclei Far from Stability, Mesonic Atoms, Exotic Interactions, New Theoretical Approaches, and New Experimental Techniques and New Nuclear Chemistry Facilities

  15. Circularly polarized antennas

    CERN Document Server

    Gao, Steven; Zhu, Fuguo

    2013-01-01

    This book presents a comprehensive insight into the design techniques for different types of CP antenna elements and arrays In this book, the authors address a broad range of topics on circularly polarized (CP) antennas. Firstly, it introduces to the reader basic principles, design techniques and characteristics of various types of CP antennas, such as CP patch antennas, CP helix antennas, quadrifilar helix antennas (QHA), printed quadrifilar helix antennas (PQHA), spiral antenna, CP slot antennas, CP dielectric resonator antennas, loop antennas, crossed dipoles, monopoles and CP horns. Adva

  16. Plasma polarization spectroscopy

    CERN Document Server

    Iwamae, Atsushi

    2008-01-01

    Plasma Polarization Spectroscopy (PPS) is now becoming a standard diagnostic technique for working with laboratory plasmas. This new area needs a comprehensive framework, both experimental and theoretical. This book reviews the historical development of PPS, develops a general theoretical formulation to deal with this phenomenon, along with an overview of relevant cross sections, and reports on laboratory experiments so far performed. It also includes various facets that are interesting from this standpoint, e.g. X-ray lasers and effects of microwave irradiation. It also offers a timely discussion of instrumentation that is quite important in a practical PPS experiment.

  17. Intermediate-range chemical ordering of cations in molten RbCl-AgCl

    Energy Technology Data Exchange (ETDEWEB)

    Tahara, S. [Department of Physics and Earth Sciences, Faculty of Science, University of the Ryukyus, Okinawa 903-0213 (Japan); Research and Utilization Division, Japan Synchrotron Radiation Research Institute (JASRI, SPring-8), Hyogo 679-5198 (Japan); Kawakita, Y. [J-PARC Center, Japan Atomic Energy Agency (JAEA), Ibaraki 319-1195 (Japan); Shimakura, H. [Faculty of Pharmacy, Niigata University of Pharmacy and Applied Life Sciences, Niigata 956-8603 (Japan); Ohara, K. [Research and Utilization Division, Japan Synchrotron Radiation Research Institute (JASRI, SPring-8), Hyogo 679-5198 (Japan); Fukami, T. [Department of Physics and Earth Sciences, Faculty of Science, University of the Ryukyus, Okinawa 903-0213 (Japan); Takeda, S. [Department of Physics, Faculty of Sciences, Kyushu University, Fukuoka 812-8581 (Japan)

    2015-07-28

    A first sharp diffraction peak (FSDP) is observed in the X-ray total structure factor of a molten mixture of RbCl-AgCl, while both pure melts of RbCl and AgCl do not exhibit FSDP individually. Molecular dynamics simulations were performed to investigate the origin of the FSDP with the polarizable ion model (PIM). Coexistence of covalent Ag–Cl and ionic Rb–Cl bonds leads the system to evolve intermediate range ordering, which is simulated by introducing the induced polarization in different ways between Ag–Cl with fully polarizable treatment based on Vashishta-Raman potential and Rb–Cl with suppression over-polarization in the nearest neighbor contribution based on Born-Meyer potential. The partial structure factors for both the Ag–Ag and Rb–Rb correlations, S{sub AgAg}(Q) and S{sub RbRb}(Q), show a positive contribution to the FSDP, while S{sub AgRb}(Q) for the Ag–Rb correlation exhibits a negative contribution, indicating that Ag and Rb ions are distributed in an alternating manner within the intermediate-range length scale. The origin of the intermediate-range chemical ordering of cations can be ascribed to the preferred direction of the dipole moments of anions in the PIM.

  18. System for measuring the proton polarization in a polarized target

    International Nuclear Information System (INIS)

    Karnaukhov, I.M.; Lukhanin, A.A.; Telegin, Yu.N.; Trotsenko, V.I.; Chechetenko, V.F.

    1984-01-01

    The system for measuring the proton polarization in a polarized target representing the high-sensitivity nuclear magnetic resonance (NMR) is described Q-meter with series connection and a circuit for measuring system resonance characteristic is used for NMR-absorption signal recording. Measuring coil is produced of a strip conductor in order to obtain uniform system sensitivity to polarization state in all target volume and improve signal-to-noise ratio. Polarization measuring system operates ion-line with the M-6000 computer. The total measuring error for the value of free proton polarization in target taking into account the error caused by local depolarization of working substance under irradiation by high-intense photon beam is <= 6%. Long-term application of the described system for measuring the proton polarization in the LUEh-20000 accelerator target used in the pion photoproduction experiments has demonstrated its high reliability

  19. Governance-Default Risk Relationship and the Demand for Intermediated and Non-Intermediated Debt

    Directory of Open Access Journals (Sweden)

    Husam Aldamen

    2012-09-01

    Full Text Available This paper explores the impact of corporate governance on the demand for intermediated debt (asset finance, bank debt, non-bank private debt and non-intermediated debt (public debt in the Australian debt market. Relative to other countries the Australian debt market is characterised by higher proportions of intermediated or private debt with a lower inherent level of information asymmetry in that private lenders have greater access to financial information (Gray, Koh & Tong 2009. Our firm level, cross-sectional evidence suggests that higher corporate governance impacts demand for debt via the mitigation of default risk. However, this relationship is not uniform across all debt types. Intermediated debt such as bank and asset finance debt are more responsive to changes in governance-default risk relationship than non-bank and non-intermediated debt. The implication is that a firm’s demand for different debt types will reflect its governance-default risk profile.

  20. Polarization and forward-backward asymmetry of $\\Lambda$ baryons in hadronic $Z^0$ decays

    CERN Document Server

    Ackerstaff, K; Allison, J; Altekamp, N; Anderson, K J; Anderson, S; Arcelli, S; Asai, S; Axen, D A; Azuelos, Georges; Ball, A H; Barberio, E; Barlow, R J; Bartoldus, R; Batley, J Richard; Baumann, S; Bechtluft, J; Beeston, C; Behnke, T; Bell, A N; Bell, K W; Bella, G; Bentvelsen, Stanislaus Cornelius Maria; Bethke, Siegfried; Biebel, O; Biguzzi, A; Bird, S D; Blobel, Volker; Bloodworth, Ian J; Bloomer, J E; Bobinski, M; Bock, P; Bonacorsi, D; Boutemeur, M; Bouwens, B T; Braibant, S; Brigliadori, L; Brown, R M; Burckhart, Helfried J; Burgard, C; Bürgin, R; Capiluppi, P; Carnegie, R K; Carter, A A; Carter, J R; Chang, C Y; Charlton, D G; Chrisman, D; Clarke, P E L; Cohen, I; Conboy, J E; Cooke, O C; Cuffiani, M; Dado, S; Dallapiccola, C; Dallavalle, G M; Davis, R; De Jong, S; del Pozo, L A; Desch, Klaus; Dienes, B; Dixit, M S; do Couto e Silva, E; Doucet, M; Duchovni, E; Duckeck, G; Duerdoth, I P; Eatough, D; Edwards, J E G; Estabrooks, P G; Evans, H G; Evans, M; Fabbri, Franco Luigi; Fanti, M; Faust, A A; Fiedler, F; Fierro, M; Fischer, H M; Fleck, I; Folman, R; Fong, D G; Foucher, M; Fürtjes, A; Futyan, D I; Gagnon, P; Gary, J W; Gascon, J; Gascon-Shotkin, S M; Geddes, N I; Geich-Gimbel, C; Geralis, T; Giacomelli, G; Giacomelli, P; Giacomelli, R; Gibson, V; Gibson, W R; Gingrich, D M; Glenzinski, D A; Goldberg, J; Goodrick, M J; Gorn, W; Grandi, C; Gross, E; Grunhaus, Jacob; Gruwé, M; Hajdu, C; Hanson, G G; Hansroul, M; Hapke, M; Hargrove, C K; Hart, P A; Hartmann, C; Hauschild, M; Hawkes, C M; Hawkings, R; Hemingway, Richard J; Herndon, M; Herten, G; Heuer, R D; Hildreth, M D; Hill, J C; Hillier, S J; Hobson, P R; Homer, R James; Honma, A K; Horváth, D; Hossain, K R; Howard, R; Hüntemeyer, P; Hutchcroft, D E; Igo-Kemenes, P; Imrie, D C; Ingram, M R; Ishii, K; Jawahery, A; Jeffreys, P W; Jeremie, H; Jimack, Martin Paul; Joly, A; Jones, C R; Jones, G; Jones, M; Jost, U; Jovanovic, P; Junk, T R; Karlen, D A; Kartvelishvili, V G; Kawagoe, K; Kawamoto, T; Kayal, P I; Keeler, Richard K; Kellogg, R G; Kennedy, B W; Kirk, J; Klier, A; Kluth, S; Kobayashi, T; Kobel, M; Koetke, D S; Kokott, T P; Kolrep, M; Komamiya, S; Kress, T; Krieger, P; Von Krogh, J; Kyberd, P; Lafferty, G D; Lahmann, R; Lai, W P; Lamarche, F; Lanske, D; Lauber, J; Lautenschlager, S R; Layter, J G; Lazic, D; Lee, A M; Lefebvre, E; Lellouch, Daniel; Letts, J; Levinson, L; Lloyd, S L; Loebinger, F K; Long, G D; Losty, Michael J; Ludwig, J; Macchiolo, A; MacPherson, A L; Mannelli, M; Marcellini, S; Markus, C; Martin, A J; Martin, J P; Martínez, G; Mashimo, T; Mättig, P; McDonald, W J; McKenna, J A; McKigney, E A; McMahon, T J; McPherson, R A; Meijers, F; Menke, S; Merritt, F S; Mes, H; Meyer, J; Michelini, Aldo; Mikenberg, G; Miller, D J; Mincer, A; Mir, R; Mohr, W; Montanari, A; Mori, T; Morii, M; Müller, U; Mihara, S; Nagai, K; Nakamura, I; Neal, H A; Nellen, B; Nisius, R; O'Neale, S W; Oakham, F G; Odorici, F; Ögren, H O; Oh, A; Oldershaw, N J; Oreglia, M J; Orito, S; Pálinkás, J; Pásztor, G; Pater, J R; Patrick, G N; Patt, J; Pearce, M J; Pérez-Ochoa, R; Petzold, S; Pfeifenschneider, P; Pilcher, J E; Pinfold, J L; Plane, D E; Poffenberger, P R; Poli, B; Posthaus, A; Rees, D L; Rigby, D; Robertson, S; Robins, S A; Rodning, N L; Roney, J M; Rooke, A M; Ros, E; Rossi, A M; Routenburg, P; Rozen, Y; Runge, K; Runólfsson, O; Ruppel, U; Rust, D R; Rylko, R; Sachs, K; Saeki, T; Sarkisyan-Grinbaum, E; Sbarra, C; Schaile, A D; Schaile, O; Scharf, F; Scharff-Hansen, P; Schenk, P; Schieck, J; Schleper, P; Schmitt, B; Schmitt, S; Schöning, A; Schröder, M; Schultz-Coulon, H C; Schumacher, M; Schwick, C; Scott, W G; Shears, T G; Shen, B C; Shepherd-Themistocleous, C H; Sherwood, P; Siroli, G P; Sittler, A; Skillman, A; Skuja, A; Smith, A M; Snow, G A; Sobie, Randall J; Söldner-Rembold, S; Springer, R W; Sproston, M; Stephens, K; Steuerer, J; Stockhausen, B; Stoll, K; Strom, D; Szymanski, P; Tafirout, R; Talbot, S D; Tanaka, S; Taras, P; Tarem, S; Teuscher, R; Thiergen, M; Thomson, M A; Von Törne, E; Towers, S; Trigger, I; Trócsányi, Z L; Tsur, E; Turcot, A S; Turner-Watson, M F; Utzat, P; Van Kooten, R; Van den Plas, D; Verzocchi, M; Vikas, P; Vokurka, E H; Voss, H; Wäckerle, F; Wagner, A; Ward, C P; Ward, D R; Watkins, P M; Watson, A T; Watson, N K; Wells, P S; Wermes, N; White, J S; Wilkens, B; Wilson, G W; Wilson, J A; Wolf, G; Wyatt, T R; Yamashita, S; Yekutieli, G; Zacek, V; Zer-Zion, D

    1998-01-01

    The longitudinal polarization, the transverse polarization, and the forward-backward asymmetry of Lambda baryons have been measured using a sample of 4.34 million hadronic Z^0 decays collected with the OPAL detector at LEP between 1990 and 1995. These results are important as an aid to the understanding of hadronization mechanisms. Significant longitudinal polarization has been observed at intermediate and high momentum. For x_E = 2 E_{Lambda}/\\sqrt{s}) > 0.3, the longitudinal polarization has been measured to be -32.9 +/- 5.5(stat) +/- 5.2(syst)%. We have observed no transverse polarization. A significant forward-backward asymmetry has been measured and can be described by a JETSET model.

  1. Materials System for Intermediate Temperature Solid Oxide Fuel Cell

    Energy Technology Data Exchange (ETDEWEB)

    Uday B. Pal; Srikanth Gopalan

    2006-01-12

    The objective of this work was to obtain a stable materials system for intermediate temperature solid oxide fuel cell (SOFC) capable of operating between 600-800 C with a power density greater than 0.2 W/cm{sup 2}. The solid electrolyte chosen for this system was La{sub 0.9}Sr{sub 0.1}Ga{sub 0.8}Mg{sub 0.2}O{sub 3}, (LSGM). To select the right electrode materials from a group of possible candidate materials, AC complex impedance spectroscopy studies were conducted between 600-800 C on symmetrical cells that employed the LSGM electrolyte. Based on the results of the investigation, LSGM electrolyte supported SOFCs were fabricated with La{sub 0.6}Sr{sub 0.4}Co{sub 0.8}Fe{sub 0.2}O{sub 3}-La{sub 0.9}Sr{sub 0.1}Ga{sub 0.8}Mg{sub 0.2}O{sub 3} (LSCF-LSGM) composite cathode and Nickel-Ce{sub 0.6}La{sub 0.4}O{sub 3} (Ni-LDC) composite anode having a barrier layer of Ce{sub 0.6}La{sub 0.4}O{sub 3} (LDC) between the LSGM electrolyte and the Ni-LDC anode. Electrical performance and stability of these cells were determined and the electrode polarization behavior as a function of cell current was modeled between 600-800 C. The electrical performance of the anode-supported SOFC was simulated assuming an electrode polarization behavior identical to the LSGM-electrolyte-supported SOFC. The simulated electrical performance indicated that the selected material system would provide a stable cell capable of operating between 600-800 C with a power density between 0.2 to 1 W/cm{sup 2}.

  2. Azimuthal polarization states for the optimization of a liquid crystal display Sony LCX038ARA in the pure-phase regime

    Science.gov (United States)

    Salamanca Vela, C. J.; Torres Moreno, Y.; Barrero Perez, J.; Acevedo Caceres, C.

    2017-12-01

    A liquid crystal display is an optoelectronic device contains molecules in an intermediate state between solid and liquid. In this work are showed numerical and experimental results of the azimuthal polarization states, which are used to optimize the pure-phase modulation of a Sony LCX038ARA LCD liquid crystal display for a linear polarized light beam with wavelength 632.8nm.

  3. Polar drive on OMEGA

    Directory of Open Access Journals (Sweden)

    Radha P.B.

    2013-11-01

    Full Text Available High-convergence polar-drive experiments are being conducted on OMEGA [T. R. Boehly et al., Opt. Commum. 133, 495 (1997] using triple-picket laser pulses. The goal of OMEGA experiments is to validate modeling of oblique laser deposition, heat conduction in the presence of nonradial thermal gradients in the corona, and implosion energetics in the presence of laser–plasma interactions such as crossed-beam energy transfer. Simulated shock velocities near the equator, where the beams are obliquely incident, are within 5% of experimentally inferred values in warm plastic shells, well within the required accuracy for ignition. High, near-one-dimensional areal density is obtained in warm-plastic-shell implosions. Simulated backlit images of the compressing core are in good agreement with measured images. Outstanding questions that will be addressed in the future relate to the role of cross-beam transfer in polar drive irradiation and increasing the energy coupled into the target by decreasing beam obliquity.

  4. Innovative spin precessor for intermediate energy protons

    International Nuclear Information System (INIS)

    Hoffman, E.W.

    1979-01-01

    A spin precessor has been designed to provide arbitrary orientation of the polarization in the external proton beam at LAMPF. The device utilizes two superconducting solenoids, three conventional dipoles, and conversion of polarized H - to H + to provide an achromatic, undeflected beam with tunable spin orientation over a range of energies from 400 MeV to 800 MeV. A portion of this device is being installed to provide compatibility between two facilities which simultaneously use two branches of the external proton beam at LAMPF

  5. Fostering teamwork in an intermediate care unit.

    Science.gov (United States)

    Spence, Heather; Cappleman, Julia

    2011-06-01

    The government has emphasised that, to deliver high quality, integrated care, staff must work across organisational boundaries using a team approach so that everyone works towards the same goals. This article describes how one NHS-managed intermediate care unit has integrated care staff employed by the independent sector.

  6. Essays in corporate finance and financial intermediation

    NARCIS (Netherlands)

    Kempf, Elisabeth

    2016-01-01

    This thesis consists of three chapters in corporate finance and financial intermediation. The first two chapters explore sources of incentives and learning for finance professionals. Specifically, the first chapter studies how the option to go work for an investment bank affects the incentives of

  7. 34 CFR 200.17 - Intermediate goals.

    Science.gov (United States)

    2010-07-01

    ..., DEPARTMENT OF EDUCATION TITLE I-IMPROVING THE ACADEMIC ACHIEVEMENT OF THE DISADVANTAGED Improving Basic.... Each State must establish intermediate goals that increase in equal increments over the period covered by the timeline under § 200.15 as follows: (a) The first incremental increase must take effect not...

  8. Trusted intermediating agents in electronic trade networks

    NARCIS (Netherlands)

    T.B. Klos (Tomas); F. Alkemade (Floortje)

    2005-01-01

    htmlabstract Electronic commerce and trading of information goods significantly impact the role of intermediaries: consumers can bypass intermediating agents by forming direct links to producers. One reason that traditional intermediaries can still make a profit, is that they have more knowledge of

  9. Intermediates and Generic Convergence to Equilibria

    DEFF Research Database (Denmark)

    Marcondes de Freitas, Michael; Wiuf, Carsten; Feliu, Elisenda

    2017-01-01

    Known graphical conditions for the generic and global convergence to equilibria of the dynamical system arising from a reaction network are shown to be invariant under the so-called successive removal of intermediates, a systematic procedure to simplify the network, making the graphical condition...

  10. Financial intermediation with credit constrained agents

    Czech Academy of Sciences Publication Activity Database

    Boháček, Radim

    2007-01-01

    Roč. 29, č. 4 (2007), s. 741-759 ISSN 0164-0704 R&D Projects: GA AV ČR IAA700850602 Institutional research plan: CEZ:AV0Z70850503 Keywords : financial intermediation * occupational choice * general equilibrium Subject RIV: AH - Economics Impact factor: 0.360, year: 2007

  11. What Should be Taught in Intermediate Macroeconomics?

    Science.gov (United States)

    de Araujo, Pedro; O'Sullivan, Roisin; Simpson, Nicole B.

    2013-01-01

    A lack of consensus remains on what should form the theoretical core of the undergraduate intermediate macroeconomic course. In determining how to deal with the Keynesian/classical divide, instructors must decide whether to follow the modern approach of building macroeconomic relationships from micro foundations, or to use the traditional approach…

  12. Interaction between Biomphalaria pfeifferi, the snail intermediate ...

    African Journals Online (AJOL)

    Biological control of snail intermediate host of human schistosome parasites has been suggested. In this study, the effect of Indoplanobis exustus a planorbid snail and possible competitor snail of Biomphalaria pfeifferi on the fecundity and growth rate of the later was evaluated. The results showed a significant difference in ...

  13. Bridge: Intelligent Tutoring with Intermediate Representations

    Science.gov (United States)

    1988-05-01

    Research and Development Center and Psychology Department University of Pittsburgh Pittsburgh, PA. 15260 The Artificial Intelligence and Psychology...problem never introduces more than one unfamiliar plan. Inteligent Tutoring With Intermediate Representations - Bonar and Cunniigbam 4 You must have a... Inteligent Tutoring With ntermediate Representations - Bonar and Cunningham 7 The requirements are specified at four differcnt levels, corresponding to

  14. Intermediality and politics in theatre and performance

    NARCIS (Netherlands)

    Dapp, G.S.

    2013-01-01

    This dissertation applies the concepts of intermediality and politics to five performances by Rimini Protokoll, Christoph Schlingensief, and Igneous, and analyzes the implications that emerge on both a significational and a theoretical level. Based on the specific mediality involved, it argues that

  15. Changes to the Intermediate Accounting Course Sequence

    Science.gov (United States)

    Davidson, Lesley H.; Francisco, William H.

    2009-01-01

    There is an ever-growing amount of information that must be covered in Intermediate Accounting courses. Due to recent accounting standards and the implementation of IFRS this trend is likely to continue. This report incorporates the results of a recent survey to examine the trend of spending more course time to cover this additional material.…

  16. Unraveling Intermediate Filaments : The super resolution solution

    NARCIS (Netherlands)

    Nahidiazar, L.

    2017-01-01

    Intermediate Filaments (IFs) carry out major functions in cells. Several diseases have been associated with malfunctioning IFs in the cells and among them are certain sub types of cancer. To determine the structure and organization of IFs, we have used Single Molecule Localization Microscopy (SMLM)

  17. Intermediate state trapping of a voltage sensor

    DEFF Research Database (Denmark)

    Lacroix, Jérôme J; Pless, Stephan Alexander; Maragliano, Luca

    2012-01-01

    transition pathway determined using the string method. The experimental results and computational analysis suggest that the phenotype of I241W may originate in the formation of a hydrogen bond between the indole nitrogen atom and the backbone carbonyl of R2. This work provides new information on intermediate...... states in voltage-gated ion channels with an approach that produces minimum chemical perturbation....

  18. Intuitionistic Rules : Admissible Rules of Intermediate Logics

    NARCIS (Netherlands)

    Goudsmit, J.P.

    2015-01-01

    In this thesis, we investigate the admissible rules of intermediate logics. On the one hand, one can characterize the admissibility of rules in certain logic, and on the other hand, one can characterize logics through their admissible rules. We take both approaches, and reach new results in both

  19. Intermediate Systems Analyst | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The intermediate Systems Analyst will bring to the System Development Group the necessary skills to understand in depth the architecture of Oracle to allow better design and implementation of new and enhanced information systems and applications. The incumbent will take full responsibility for the ITM division's ...

  20. Software Testing An ISEB Intermediate Certificate

    CERN Document Server

    Hambling, Brian

    2009-01-01

    Covering testing fundamentals, reviews, testing and risk, test management and test analysis, this book helps newly qualified software testers to learn the skills and techniques to take them to the next level. Written by leading authors in the field, this is the only official textbook of the ISEB Intermediate Certificate in Software Testing.

  1. Bismuth phosphates as intermediate temperature proton conductors

    DEFF Research Database (Denmark)

    Huang, Yunjie; Christensen, Erik; Shuai, Qin

    2017-01-01

    Proton conducting electrolyte materials operational in the intermediate temperature range of 200-400 °C are of special interest for applications in fuel cells and water electrolysers. Bismuth phosphates in forms of polycrystalline powders and amorphous glasses are synthesized and investigated...

  2. Polarized proton collider at RHIC

    Energy Technology Data Exchange (ETDEWEB)

    Alekseev, I.; Allgower, C.; Bai, M.; Batygin, Y.; Bozano, L.; Brown, K.; Bunce, G.; Cameron, P.; Courant, E.; Erin, S.; Escallier, J.; Fischer, W.; Gupta, R.; Hatanaka, K.; Huang, H.; Imai, K.; Ishihara, M.; Jain, A.; Lehrach, A.; Kanavets, V.; Katayama, T.; Kawaguchi, T.; Kelly, E.; Kurita, K.; Lee, S.Y.; Luccio, A.; MacKay, W.W. E-mail: mackay@bnl.govhttp://www.rhichome.bnl.gov/People/waldowaldo@bnl.gov; Mahler, G.; Makdisi, Y.; Mariam, F.; McGahern, W.; Morgan, G.; Muratore, J.; Okamura, M.; Peggs, S.; Pilat, F.; Ptitsin, V.; Ratner, L.; Roser, T.; Saito, N.; Satoh, H.; Shatunov, Y.; Spinka, H.; Syphers, M.; Tepikian, S.; Tominaka, T.; Tsoupas, N.; Underwood, D.; Vasiliev, A.; Wanderer, P.; Willen, E.; Wu, H.; Yokosawa, A.; Zelenski, A.N

    2003-03-01

    In addition to heavy ion collisions (RHIC Design Manual, Brookhaven National Laboratory), RHIC will also collide intense beams of polarized protons (I. Alekseev, et al., Design Manual Polarized Proton Collider at RHIC, Brookhaven National Laboratory, 1998, reaching transverse energies where the protons scatter as beams of polarized quarks and gluons. The study of high energy polarized protons beams has been a long term part of the program at BNL with the development of polarized beams in the Booster and AGS rings for fixed target experiments. We have extended this capability to the RHIC machine. In this paper we describe the design and methods for achieving collisions of both longitudinal and transverse polarized protons in RHIC at energies up to {radical}s=500 GeV.

  3. Spin exchange in polarized deuterium

    International Nuclear Information System (INIS)

    Przewoski, B. von; Meyer, H.O.; Balewski, J.; Doskow, J.; Ibald, R.; Pollock, R.E.; Rinckel, T.; Wellinghausen, A.; Whitaker, T.J.; Daehnick, W.W.; Haeberli, W.; Schwartz, B.; Wise, T.; Lorentz, B.; Rathmann, F.; Pancella, P.V.; Saha, Swapan K.; Thoerngren-Engblom, P.

    2003-01-01

    We have measured the vector and tensor polarization of an atomic deuterium target as a function of the target density. The polarized deuterium was produced in an atomic beam source and injected into a storage cell. For this experiment, the atomic beam source was operated without rf transitions, in order to avoid complications from the unknown efficiency of these transitions. In this mode, the atomic beam is vector and tensor polarized and both polarizations can be measured simultaneously. We used a 1.2-cm-diam and 27-cm-long storage cell, which yielded an average target density between 3 and 9x10 11 at/cm 3 . We find that the tensor polarization decreases with increasing target density while the vector polarization remains constant. The data are in quantitative agreement with the calculated effect of spin exchange between deuterium atoms at low field

  4. Linear polarization of BY Draconis

    International Nuclear Information System (INIS)

    Koch, R.H.; Pfeiffer, R.J.

    1976-01-01

    Linear polarization measurements are reported in four bandpasses for the flare star BY Dra. The red polarization is intrinsically variable at a confidence level greater than 99 percent. On a time scale of many months, the variability is not phase-locked to either a rotational or a Keplerian ephemeris. The observations of the three other bandpasses are useful principally to indicate a polarization spectrum rising toward shorter wavelengths

  5. Polarity in Mammalian Epithelial Morphogenesis

    OpenAIRE

    Roignot, Julie; Peng, Xiao; Mostov, Keith

    2013-01-01

    Cell polarity is fundamental for the architecture and function of epithelial tissues. Epithelial polarization requires the intervention of several fundamental cell processes, whose integration in space and time is only starting to be elucidated. To understand what governs the building of epithelial tissues during development, it is essential to consider the polarization process in the context of the whole tissue. To this end, the development of three-dimensional organotypic cell culture model...

  6. NetMHCIIpan-3.0, a common pan-specific MHC class II prediction method including all three human MHC class II isotypes, HLA-DR, HLA-DP and HLA-DQ

    DEFF Research Database (Denmark)

    Karosiene, Edita; Rasmussen, Michael; Blicher, Thomas

    2013-01-01

    importance for understanding the nature of immune responses and identifying T cell epitopes for the design of new vaccines and immunotherapies. Given the large number of MHC variants, and the costly experimental procedures needed to evaluate individual peptide–MHC interactions, computational predictions have...... become particularly attractive as first-line methods in epitope discovery. However, only a few so-called pan-specific prediction methods capable of predicting binding to any MHC molecule with known protein sequence are currently available, and all of them are limited to HLA-DR. Here, we present the first...... pan-specific method capable of predicting peptide binding to any HLA class II molecule with a defined protein sequence. The method employs a strategy common for HLA-DR, HLA-DP and HLA-DQ molecules to define the peptide-binding MHC environment in terms of a pseudo sequence. This strategy allows...

  7. A polarized alkali ion source

    International Nuclear Information System (INIS)

    Boettger, R.; Tungate, G.; Bauer, B.; Egelhof, P.; Moebius, K.H.; Steffens, E.

    1978-01-01

    The beam foil technique has been applied to detect nuclear vector polarization of a 10 keV 23 Na + beam. The result was about 70% of the atomic beam polarization thus limiting the depolarization by the surface ionizer to at most 30%. In a Coulomb excitation experiment with a tensor polarized 42 MeV 23 Na 7+ beam an effect of 0.011 +- 0.003 was measured yielding a value of t 20 approx. 0.04 for the beam polarization. The depolarization during the acceleration process can be estimated to be about 0.8. (orig.) [de

  8. The SLAC polarized electron source

    International Nuclear Information System (INIS)

    Tang, H.; Alley, R.; Frisch, J.

    1995-06-01

    The SLAC polarized electron source employs a photocathode DC high voltage gun with a loadlock and a YAG pumped Ti:sapphire laser system for colliding beam experiments or a flash lamp pumped Ti:sapphire laser for fixed target experiments. It uses a thin, strained GaAs(100) photocathode, and is capable of producing a pulsed beam with a polarization of ≥80% and a peak current exceeding 10 A. Its operating efficiency has reached 99%. The physics and technology of producing high polarization electron beams from a GaAs photocathode will be reviewed. The prospects of realizing a polarized electron source for future linear colliders will also be discussed

  9. Structure of Mandelate Racemase with Bound Intermediate Analogues Benzohydroxamate and Cupferron

    Energy Technology Data Exchange (ETDEWEB)

    Lietzan, Adam D.; Nagar, Mitesh; Pellmann, Elise A.; Bourque, Jennifer R.; Bearne, Stephen L.; Maurice, Martin St. (Dalhousie U.); (Marquette)

    2012-05-09

    Mandelate racemase (MR, EC 5.1.2.2) from Pseudomonas putida catalyzes the Mg{sup 2+}-dependent interconversion of the enantiomers of mandelate, stabilizing the altered substrate in the transition state by 26 kcal/mol relative to the substrate in the ground state. To understand the origins of this binding discrimination, we determined the X-ray crystal structures of wild-type MR complexed with two analogues of the putative aci-carboxylate intermediate, benzohydroxamate and Cupferron, to 2.2-{angstrom} resolution. Benzohydroxamate is shown to be a reasonable mimic of the transition state and/or intermediate because its binding affinity for 21 MR variants correlates well with changes in the free energy of transition state stabilization afforded by these variants. Both benzohydroxamate and Cupferron chelate the active site divalent metal ion and are bound in a conformation with the phenyl ring coplanar with the hydroxamate and diazeniumdiolate moieties, respectively. Structural overlays of MR complexed with benzohydroxamate, Cupferron, and the ground state analogue (S)-atrolactate reveal that the para carbon of the substrate phenyl ring moves by 0.8-1.2 {angstrom} between the ground state and intermediate state, consistent with the proposal that the phenyl ring moves during MR catalysis while the polar groups remain relatively fixed. Although the overall protein structure of MR with bound intermediate analogues is very similar to that of MR with bound (S)-atrolactate, the intermediate-Mg{sup 2+} distance becomes shorter, suggesting a tighter complex with the catalytic Mg{sup 2+}. In addition, Tyr 54 moves closer to the phenyl ring of the bound intermediate analogues, contributing to an overall constriction of the active site cavity. However, site-directed mutagenesis experiments revealed that the role of Tyr 54 in MR catalysis is relatively minor, suggesting that alterations in enzyme structure that contribute to discrimination between the altered substrate in the

  10. Fate of oxygenated intermediates in solar irradiated diluted bitumen mixed with saltwater.

    Science.gov (United States)

    Yang, Zeyu; Zhang, Gong; Hollebone, Bruce P; Brown, Carl E; Yang, Chun; Lambert, Patrick; Wang, Zhendi; Landriault, Mike; Shah, Keval

    2017-12-01

    Two types of diluted bitumen (dilbit) and a light crude oil spiked onto the surface of saltwater were irradiated with natural solar light in Ottawa to assess the impact of sunlight to the fate of oxygenated intermediates. Oxygenated components, including carbonyl polycyclic aromatic hydrocarbons (PAHs) and acidic polar fractions (naphthenic acid fraction compounds, NAFCs), were identified after periods of solar exposure under both winter and summer conditions. Carbonyl PAHs and NAFCs were formed in both seasons; however, light crude and summer irradiation produced higher abundance of them than dilbits and winter exposure. The formed NAFCs were abundant with the congeners containing a heteroatom of oxygen only (O o species), accompanied by the minor amounts of sulfur- and nitrogen-containing acids. The produced O o species were predominant with the congeners with light molecular weight, high degree of saturation and heavy oxygen numbers. For both carbonyl PAHs and NAFCs, their abundance continually increased throughout the period of winter exposure. In the summer, some carbonyl PAHs and all O o species increased during the early exposure period; then they decreased with continued exposure for most oils, illustrating their transitional nature. Oxygenated intermediates thus appear to have been created through the photo-oxidation of non-to medium-polar petroleum hydrocarbons or the intermediates of aldehydes or ketones (O 1 ). Oil properties, the duration of exposure, exposure season and the chemical structure of these intermediates are critical factors controlling their fate through photo-oxidation. The observed chemical changes highlight the effects of sunlight on the potential behavior, fate and impact of spilled oil, with the creation of new resin group compounds and the reduction of aromatics and saturates. These results also imply that the ecological effects of spilled oil, after ageing in sunlight, depend on the specific oil involved and the environmental

  11. Probing in-medium spin–orbit interaction with intermediate-energy heavy-ion collisions

    International Nuclear Information System (INIS)

    Xu, Jun; Li, Bao-An

    2013-01-01

    Incorporating for the first time both the spin and isospin degrees of freedom explicitly in transport model simulations of intermediate-energy heavy-ion collisions, we observe that a local spin polarization appears during collision process. Most interestingly, it is found that the nucleon spin up–down differential transverse flow is a sensitive probe of the spin–orbit interaction, providing a novel approach to probe both the density and isospin dependence of the in-medium spin–orbit coupling that is important for understanding the structure of rare isotopes and synthesis of superheavy elements

  12. Polar Biomedical Research - An Assessment.

    Science.gov (United States)

    1982-10-01

    to grow more crops in subpolar Alaska. The severity of the polar conditions in Antarctica allow no practical method for providing volumes of plant food...for an expanded population. Any experiments in polar regions in food production involving geothermal heat, solar energy, hydroponics , or aquaculture

  13. Create a Polarized Light Show.

    Science.gov (United States)

    Conrad, William H.

    1992-01-01

    Presents a lesson that introduces students to polarized light using a problem-solving approach. After illustrating the concept using a slinky and poster board with a vertical slot, students solve the problem of creating a polarized light show using Polya's problem-solving methods. (MDH)

  14. Carbon nanotube fiber terahertz polarizer

    Energy Technology Data Exchange (ETDEWEB)

    Zubair, Ahmed [Department of Electrical and Computer Engineering, Rice University, Houston, Texas 77005 (United States); Tsentalovich, Dmitri E.; Young, Colin C. [Department of Chemical and Biomolecular Engineering, Rice University, Houston, Texas 77005 (United States); Heimbeck, Martin S. [Charles M. Bowden Laboratory, Aviation & Missile Research, Development, and Engineering Center (AMRDEC), Redstone Arsenal, Alabama 35898 (United States); Everitt, Henry O. [Department of Electrical and Computer Engineering, Rice University, Houston, Texas 77005 (United States); Charles M. Bowden Laboratory, Aviation & Missile Research, Development, and Engineering Center (AMRDEC), Redstone Arsenal, Alabama 35898 (United States); Pasquali, Matteo [Department of Chemical and Biomolecular Engineering, Rice University, Houston, Texas 77005 (United States); Department of Chemistry, Rice University, Houston, Texas 77005 (United States); Department of Materials Science and NanoEngineering, Rice University, Houston, Texas 77005 (United States); Kono, Junichiro, E-mail: kono@rice.edu [Department of Electrical and Computer Engineering, Rice University, Houston, Texas 77005 (United States); Department of Materials Science and NanoEngineering, Rice University, Houston, Texas 77005 (United States); Department of Physics and Astronomy, Rice University, Houston, Texas 77005 (United States)

    2016-04-04

    Conventional, commercially available terahertz (THz) polarizers are made of uniformly and precisely spaced metallic wires. They are fragile and expensive, with performance characteristics highly reliant on wire diameters and spacings. Here, we report a simple and highly error-tolerant method for fabricating a freestanding THz polarizer with nearly ideal performance, reliant on the intrinsically one-dimensional character of conduction electrons in well-aligned carbon nanotubes (CNTs). The polarizer was constructed on a mechanical frame over which we manually wound acid-doped CNT fibers with ultrahigh electrical conductivity. We demonstrated that the polarizer has an extinction ratio of ∼−30 dB with a low insertion loss (<0.5 dB) throughout a frequency range of 0.2–1.1 THz. In addition, we used a THz ellipsometer to measure the Müller matrix of the CNT-fiber polarizer and found comparable attenuation to a commercial metallic wire-grid polarizer. Furthermore, based on the classical theory of light transmission through an array of metallic wires, we demonstrated the most striking difference between the CNT-fiber and metallic wire-grid polarizers: the latter fails to work in the zero-spacing limit, where it acts as a simple mirror, while the former continues to work as an excellent polarizer even in that limit due to the one-dimensional conductivity of individual CNTs.

  15. Polarization-preserving holey fibers

    DEFF Research Database (Denmark)

    Broeng, Jes; Mogilevtsev, Dmitri; Libori, Stig E. Barkou

    2001-01-01

    In this work we suggest and discuss a microstructure of air capillaries with elliptical cross-section in a tread of glass that gives opportunity for Creation of polarization-preserving fiber with very small beat length between the fundamental modes of different polarization...

  16. Polarized Scintillating Targets at Psi

    Science.gov (United States)

    van den Brandt, B.; Bunyatova, E. I.; Hautle, P.; Konter, J. A.; Mango, S.

    2001-02-01

    Scintillating polarized targets are now routinely available: blocks of 18×18×5 mm scintillating organic polymer, doped with TEMPO, polarized dynamically in a field of 2.5 T in a vertical 3He-4He dilution refrigerator. A 19 mm diameter plastic lightguide transports the scintillation light from the sample in the mixing chamber to a photomultiplier outside the cryostat.

  17. UV Coatings, Polarization, and Coronagraphy

    Science.gov (United States)

    Bolcar, Matthew R.; Quijada, Manuel; West, Garrett; Balasubramanian, Bala; Krist, John; Martin, Stefan; Sabatke, Derek

    2016-01-01

    Presenation for the Large UltraViolet Optical Infrared (LUVOIR) and Habitable Exoplanet Imager (HabEx) Science and Technology Definition Teams (STDT) on technical considerations regarding ultraviolet coatings, polarization, and coronagraphy. The presentations review the state-of-the-art in ultraviolet coatings, how those coatings generate polarization aberrations, and recent study results from both the LUVOIR and HabEx teams.

  18. Polarization Imaging and Insect Vision

    Science.gov (United States)

    Green, Adam S.; Ohmann, Paul R.; Leininger, Nick E.; Kavanaugh, James A.

    2010-01-01

    For several years we have included discussions about insect vision in the optics units of our introductory physics courses. This topic is a natural extension of demonstrations involving Brewster's reflection and Rayleigh scattering of polarized light because many insects heavily rely on optical polarization for navigation and communication.…

  19. Climate Drives Polar Bear Origins

    Science.gov (United States)

    In their provocative analysis of northern bears (“Nuclear genomic sequences reveal that polar bears are an old and distinct bear lineage,” Reports, 20 April, p. 344), F. Hailer et al. use independent nuclear loci to show that polar bears originated during the middle Pleistocene, rather than during t...

  20. Opening the Black Box of Intermediation

    DEFF Research Database (Denmark)

    Nowinska, Agnieszka

    ) and at the interfirm level (between partners and within alliances and associations).The tentative results show that both of these levels are important in defining the intermediating firms' business models and in answering their environmental threats and in building up competitive advantage. The paper ends with a short......This paper attempts to answer how external environmental factors affect intermediating firms within the maritime industry - the middlemen that plays a very important role in the sector. The category encompasses firms such as liner and port agencies, freight forwarders and shipbrokers, who link......, by its global character and by volatility. As such, the industry offers an interesting and generalizable environment for research. Moreover, the choice of the middleman, an intermediary in the value chain, as the object of study, offers additional insights into the complex industry and value chain...

  1. Intermediate storage for the Start accelerator

    International Nuclear Information System (INIS)

    Gaponenko, N.I.; Tkach, Yu.V.; Stepanenko, I.A.; Kozachek, A.S.; Komarov, A.D.; Gadetskij, N.P.

    1988-01-01

    Usage of the chain of series-connected capacitors, placed near the voltage pulse generator (VPG) cascades, as an intermediate storage (IS) has allowed to reduce the inductance of the PG-IS charging circuit and to reduce storage charging time up to 30 ns. In such cases the electrical strength of the IS capacitor insulation is essentially higher, than at dc voltage, it has allowed to reduce the number of capacitors in the chain and to reduce IS self-inductance. Additional ways to reduce the inductance of the VPG-IS charging circuit are considered. Reduction of storage charging time has allowed to stabilize the operation of the commutator, which connects the intermediate storage with the accelerator shaping line

  2. General analysis of the intermediate vector boson production in hadron collisions

    International Nuclear Information System (INIS)

    Rekalo, M.P.

    1981-01-01

    Polarization states of intermediate vector W(Z) bosons produced in inclusive hadron-hadron collisions, a 1 +a 2 →W(Z)+X, where a 1 a 2 are some nonpolarized hadrons, X is a nondetected particle assembly are studied in general. Since spatial parity in these processes is not preserved, polarized W(Z) boson production must be determined by 9 real structural functions, 4 of which characterize the effects of invariance violation in relation to spatial reflections. Three structural functions (P-odd) for pole W(Z) production mechanisms in the quantum chromodynamics should exactly equal zero (with regard to the gluon errors). The relation of the W(Z) matrix elements with the structural functions in different coordinate systems used while discussing the angular distributions of W(Z) boson decay products is established. Decription of the W(Z) polarization properties is analyzed in terms of the 4-vector of spin and tenzor of quadrupole polarization [ru

  3. Far from the intermediate nuclear field

    International Nuclear Information System (INIS)

    Dietrich, K.; Wagner, G.J.; Gregoire, C.; Campi, X.; Silvestre-Brac, B.; Platchkov, S.; Mayer, B.; Abgrall, Y.; Bohigas, O.; Grange, P.; Signarbieux, C.

    1988-01-01

    Pairing correlations in nuclear physics; the BCS state and quasi-particles; the layer model; collision effects on nuclear dynamics; the theory of cluster formation (application to nucleus fragmentation); short range correlations (few-particle systems); deuterium electron scattering; dibaryonic resonances; traditional and exotic hadron probes of nuclear structure; spectral fluctuations and chaotic motion; corrections to the intermediate nuclear field (nonrelativistic and other effects); and heavy nuclei splitting and nuclear superfluidity are introduced [fr

  4. International express student's book : pre-intermediate

    CERN Document Server

    Taylor, Liz

    1996-01-01

    The New Edition of International Express Pre-Intermediate retains all the keys features of this popular and successel four-level course. It combines engaging, up-to-date topics with a time-efficient and student-centred approach to language work, and clearly focused activities that reflect learner's real communicative needs - the ideal course for professional adults who use English for work, travel, and socializing.

  5. Assembly of intermediates for rapid membrane fusion.

    Science.gov (United States)

    Harner, Max; Wickner, William

    2018-01-26

    Membrane fusion is essential for intracellular protein sorting, cell growth, hormone secretion, and neurotransmission. Rapid membrane fusion requires tethering and Sec1-Munc18 (SM) function to catalyze R-, Qa-, Qb-, and Qc-SNARE complex assembly in trans , as well as SNARE engagement by the SNARE-binding chaperone Sec17/αSNAP. The hexameric vacuolar HOPS ( ho motypic fusion and vacuole p rotein s orting) complex in the yeast Saccharomyces cerevisiae tethers membranes through its affinities for the membrane Rab GTPase Ypt7. HOPS also has specific affinities for the vacuolar SNAREs and catalyzes SNARE complex assembly, but the order of their assembly into a 4-SNARE complex is unclear. We now report defined assembly intermediates on the path to membrane fusion. We found that a prefusion intermediate will assemble with HOPS and the R, Qa, and Qc SNAREs, and that this assembly undergoes rapid fusion upon addition of Qb and Sec17. HOPS-tethered membranes and all four vacuolar SNAREs formed a complex that underwent an even more dramatic burst of fusion upon Sec17p addition. These findings provide initial insights into an ordered fusion pathway consisting of the following intermediates and events: 1) Rab- and HOPS-tethered membranes, 2) a HOPS:R:Qa:Qc trans -complex, 3) a HOPS:4-SNARE trans -complex, 4) an engagement with Sec17, and 5) the rapid lipid rearrangements during fusion. In conclusion, our results indicate that the R:Qa:Qc complex forms in the context of membrane, Ypt7, HOPS, and trans -SNARE assembly and serves as a functional intermediate for rapid fusion after addition of the Qb-SNARE and Sec17 proteins. © 2018 by The American Society for Biochemistry and Molecular Biology, Inc.

  6. Integrins and epithelial cell polarity.

    Science.gov (United States)

    Lee, Jessica L; Streuli, Charles H

    2014-08-01

    Cell polarity is characterised by differences in structure, composition and function between at least two poles of a cell. In epithelial cells, these spatial differences allow for the formation of defined apical and basal membranes. It has been increasingly recognised that cell-matrix interactions and integrins play an essential role in creating epithelial cell polarity, although key gaps in our knowledge remain. This Commentary will discuss the mounting evidence for the role of integrins in polarising epithelial cells. We build a model in which both inside-out signals to polarise basement membrane assembly at the basal surface, and outside-in signals to control microtubule apical-basal orientation and vesicular trafficking are required for establishing and maintaining the orientation of epithelial cell polarity. Finally, we discuss the relevance of the basal integrin polarity axis to cancer. This article is part of a Minifocus on Establishing polarity. © 2014. Published by The Company of Biologists Ltd.

  7. Hyperon polarization: An experimental overview

    International Nuclear Information System (INIS)

    Lach, J.

    1992-12-01

    The fact that inclusively produced hyperons are produced with significant polarization was first discovered at Fermilab about seventeen years ago. This and subsequent experiments showed that Λ degree were produced polarized while bar Λ degree had no polarization in the same kinematical region. This set the stage for many experiments which showed that most hyperons are produced polarized. Recent Fermilab experiments have showed that this phenomena is even more complex than previously thought and theoretical understanding is still lacking. Nevertheless polarized hyperon beams have been an extremely useful experimental tool in measuring hyperon magnetic moments and hyperon β-decay. Recently, hyperon radiative decays have been studied and magnetic moment precession of channeled particles in bent crystals has been observed

  8. A review of polarized ion sources

    International Nuclear Information System (INIS)

    Schmor, P.W.

    1995-06-01

    The two main types of polarized ion sources in use on accelerators today are the Atomic Beam Polarized Ion Source (ABIS) source and the Optically Pumped Polarized Ion Source (OPPIS). Both types can provide beams of nuclearly polarized light ions which are either positively or negatively charged. Heavy ion polarized ion sources for accelerators are being developed. (author). 35 refs., 1 tab

  9. Promoting Diversity Through Polar Interdisciplinary Coordinated Education (Polar ICE)

    Science.gov (United States)

    McDonnell, J. D.; Hotaling, L. A.; Garza, C.; Van Dyk, P. B.; Hunter-thomson, K. I.; Middendorf, J.; Daniel, A.; Matsumoto, G. I.; Schofield, O.

    2017-12-01

    Polar Interdisciplinary Coordinated Education (ICE) is an education and outreach program designed to provide public access to the Antarctic and Arctic regions through polar data and interactions with the scientists. The program provides multi-faceted science communication training for early career scientists that consist of a face-to face workshop and opportunities to apply these skills. The key components of the scientist training workshop include cultural competency training, deconstructing/decoding science for non-expert audiences, the art of telling science stories, and networking with members of the education and outreach community and reflecting on communication skills. Scientists partner with educators to provide professional development for K-12 educators and support for student research symposia. Polar ICE has initiated a Polar Literacy initiative that provides both a grounding in big ideas in polar science and science communication training designed to underscore the importance of the Polar Regions to the public while promoting interdisciplinary collaborations between scientists and educators. Our ultimate objective is to promote STEM identity through professional development of scientists and educators while developing career awareness of STEM pathways in Polar science.

  10. POLARIZED LIGHT IN PHYSIOTHERAPY

    Directory of Open Access Journals (Sweden)

    L. D. Tondiy

    2015-12-01

    Full Text Available The data on polarized light (PS - a new promising treatment, rehabilitation and prevention, which took its deserved place among the known therapeutic physical factors and may even compete with laser radiation of low and LED therapy. It is reflected the significant contribution of domestic scientists in the study of aircraft action on the body, its introduction in the treatment, rehabilitation and prevention of grippe, ARI. These action's mechanisms of the aircraft on the electro-physiological processes in the body that have the leading role in the regulation of its life. The new moment in the study of aircraft on the body is the evidence of its positive impact on the mechanisms of self body - its different units: the disease's banning - a revitalization of the stress-protective, stress-limiting system antioxidial, detoxification and other protection systems, the formation by the body antiviral and antimicrobial specific substances (interferon and lysozyme, activation of the immune system, phagocytosis, protective functions of skin. The protective and mobilizing role of the second link is studied: which is triggered in case of occurrence of disease or preexisting diseases: PL mobilized processes of restitution, reparations, compensation, immunity and microcirculation. The authors studied the possibility of aircraft's using to enhance performance, reduce side effects of physical factors, which are often used in the treatment (electric methods, treatment by sound, fresh and mineral water, etc..

  11. Update of the Polar SWIFT model for polar stratospheric ozone loss (Polar SWIFT version 2)

    Science.gov (United States)

    Wohltmann, Ingo; Lehmann, Ralph; Rex, Markus

    2017-07-01

    The Polar SWIFT model is a fast scheme for calculating the chemistry of stratospheric ozone depletion in polar winter. It is intended for use in global climate models (GCMs) and Earth system models (ESMs) to enable the simulation of mutual interactions between the ozone layer and climate. To date, climate models often use prescribed ozone fields, since a full stratospheric chemistry scheme is computationally very expensive. Polar SWIFT is based on a set of coupled differential equations, which simulate the polar vortex-averaged mixing ratios of the key species involved in polar ozone depletion on a given vertical level. These species are O3, chemically active chlorine (ClOx), HCl, ClONO2 and HNO3. The only external input parameters that drive the model are the fraction of the polar vortex in sunlight and the fraction of the polar vortex below the temperatures necessary for the formation of polar stratospheric clouds. Here, we present an update of the Polar SWIFT model introducing several improvements over the original model formulation. In particular, the model is now trained on vortex-averaged reaction rates of the ATLAS Chemistry and Transport Model, which enables a detailed look at individual processes and an independent validation of the different parameterizations contained in the differential equations. The training of the original Polar SWIFT model was based on fitting complete model runs to satellite observations and did not allow for this. A revised formulation of the system of differential equations is developed, which closely fits vortex-averaged reaction rates from ATLAS that represent the main chemical processes influencing ozone. In addition, a parameterization for the HNO3 change by denitrification is included. The rates of change of the concentrations of the chemical species of the Polar SWIFT model are purely chemical rates of change in the new version, whereas in the original Polar SWIFT model, they included a transport effect caused by the

  12. Nuclear physics with polarized particles

    CERN Document Server

    Paetz gen Schieck, Hans

    2012-01-01

    The measurement of spin-polarization observables in reactions of nuclei and particles is of great utility and advantage when the effects of single-spin sub-states are to be investigated. Indeed, the unpolarized differential cross-section encompasses the averaging over the spin states of the particles, and thus loses details of the interaction process. This introductory text combines, in a single volume, course-based lecture notes on spin physics and on polarized-ion sources with the aim of providing a concise yet self-contained starting point for newcomers to the field, as well as for lecturers in search of suitable material for their courses and seminars. A significant part of the book is devoted to introducing the formal theory-a description of polarization and of nuclear reactions with polarized particles. The remainder of the text describes the physical basis of methods and devices necessary to perform experiments with polarized particles and to measure polarization and polarization effects in nuclear rea...

  13. Polarization transfer in relativistic magnetized plasmas

    Science.gov (United States)

    Heyvaerts, Jean; Pichon, Christophe; Prunet, Simon; Thiébaut, Jérôme

    2013-04-01

    The polarization transfer coefficients of a relativistic magnetized plasma are derived. These results apply to any momentum distribution function of the particles, isotropic or anisotropic. Particles interact with the radiation either in a non-resonant mode when the frequency of the radiation exceeds their characteristic synchrotron emission frequency or quasi-resonantly otherwise. These two classes of particles contribute differently to the polarization transfer coefficients. For a given frequency, this dichotomy corresponds to a regime change in the dependence of the transfer coefficients on the parameters of the particle's population, since these parameters control the relative weight of the contribution of each class of particles. Our results apply to either regimes as well as the intermediate one. The derivation of the transfer coefficients involves an exact expression of the conductivity tensor of the relativistic magnetized plasma that has not been used hitherto in this context. Suitable expansions valid at frequencies much larger than the cyclotron frequency allow us to analytically perform the summation over all resonances at high harmonics of the relativistic gyrofrequency. The transfer coefficients are represented in the form of two-variable integrals that can be conveniently computed for any set of parameters by using Olver's expansion of high-order Bessel functions. We particularize our results to a number of distribution functions, isotropic, thermal or power law, with different multipolar anisotropies of low order, or strongly beamed. Specifically, earlier exact results for thermal distributions are recovered. For isotropic distributions, the Faraday coefficients are expressed in the form of a one-variable quadrature over energy, for which we provide the kernels in the high-frequency limit and in the asymptotic low-frequency limit. An interpolation formula extending over the full energy range is proposed for these kernels. A similar reduction to a

  14. Few-body experiments with polarized beams and polarized targets

    International Nuclear Information System (INIS)

    Simmons, J.E.

    1983-01-01

    A survey is presented concerning recent polarization experiments in the elastic p-d, p- 3 He, and p- 4 He systems. Mention is made of selected neutron experiments. The nominal energy range is 10 to 1000 MeV. Recent results and interpretations of the p-d system near 10 MeV are discussed. New experiments on the energy dependence of back angle p-d tensor polarization are discussed with respect to resolution of discrepancies and difficulty of theoretical interpretation. Progress is noted concerning multiple scattering interpretation of forward p-d deuteron polarization. Some new results are presented concerning the p- 3 He system and higher energy p- 4 He polarization experiments. 52 references

  15. Planck intermediate results XXXII. The relative orientation between the magnetic field and structures traced by interstellar dust

    DEFF Research Database (Denmark)

    Adam, R.; Ade, P. A. R.; Aghanim, N.

    2016-01-01

    counterparts in the Stokes Q and/or U maps. We focus our study on structures at intermediate and high Galactic latitudes, which cover two orders of magnitude in column density, from 1020 to 1022 cm2. We measure the magnetic field orientation on the plane of the sky from the polarization data, and present...... to be between 0.6 and 1.0, with a preferred value of 0.8. We find that the ridges are usually aligned with the magnetic field measured on the structures. This statistical trend becomes more striking for increasing polarization fraction and decreasing column density. There is no alignment for the highest column...... density ridges. We interpret the increase in alignment with polarization fraction as a consequence of projection effects. We present maps to show that the decrease in alignment for high column density is not due to a loss of correlation between the distribution of matter and the geometry of the magnetic...

  16. Experimental studies of nucleon-nucleon and pion-nucleus interactions at intermediate energies: Annual progress report, 1988--1989

    International Nuclear Information System (INIS)

    1988-01-01

    This report summarizes the work on experimental research in intermediate energy nuclear and particle physics carried out by New Mexico State University in 1988 under a grant from the US Department of Energy. The nucleon-nucleon research has involved studies of interactions between polarized neutrons and polarized protons. Its purpose is to help complete the determination of the nucleon-nucleon amplitudes at energies up to 800 MeV, as part of a program currently in progress at LAMPF, as well as to investigate the possibility of the existence of dibaryon resonances. The pion-nucleus research involves studies of this interaction in regions where it has not been adequately explored. These include experiments on elastic and double charge exchange scattering at energies above the /Delta/(1232) resonance, interactions with polarized nuclear targets, and investigations of pion absorption using a detector covering nearly the full solid angle region. 21 refs., 4 figs

  17. Elite Polarization and Public Opinion

    DEFF Research Database (Denmark)

    Robison, Joshua; Mullinix, Kevin

    2016-01-01

    Elite polarization has reshaped American politics and is an increasingly salient aspect of news coverage within the United States. As a consequence, a burgeoning body of research attempts to unravel the effects of elite polarization on the mass public. However, we know very little about how...... attitudes. In our first study, we show that criticism of polarization leads partisans to more positively evaluate the argument offered by their non-preferred party, increases support for bi-partisanship, but ultimately does not change the extent to which partisans follow their party’s policy endorsements...

  18. Acceleration of polarized proton beams

    International Nuclear Information System (INIS)

    Roser, T.

    1998-01-01

    The acceleration of polarized beams in circular accelerators is complicated by the numerous depolarizing spin resonances. Using a partial Siberian snake and a rf dipole that ensure stable adiabatic spin motion during acceleration has made it possible to accelerate polarized protons to 25 GeV at the Brookhaven AGS. Full Siberian snakes are being developed for RHIC to make the acceleration of polarized protons to 250 GeV possible. A similar scheme is being studied for the 800 GeV HERA proton accelerator

  19. Polarimetry with azimuthally polarized light

    Science.gov (United States)

    de Sande, Juan Carlos González; Piquero, Gemma; Santarsiero, Massimo

    2018-03-01

    Nonuniformly polarized light can be used for Mueller polarimetry of homogeneous linear samples. In this work, a set up based on using azimuthally polarized input light and a modified commercial light polarimeter is proposed and developed. With this set up, a Mueller submatrix of a sample can be obtained by measuring the Stokes parameters at only three different positions across the output beam section. Symmetry constraints for linear deterministic samples allow the complete Mueller matrix to be deduced for this kind of specimens. The experimental results obtained for phase plates and for a linear polarizer confirm the validity of the proposed method.

  20. Polarized deuteron elastic scattering from a polarized proton target

    International Nuclear Information System (INIS)

    Schmelzer, R.; Kuiper, H.; Schoeberl, M.; Berber, S.; Hilmert, H.; Koeppel, R.; Pferdmenges, R.; Zankel, H.

    1983-01-01

    Measurements are reported of the spin correlation parameter Cy,y for the elastic scattering of 10.0 MeV vector polarized deuterons from a polarized proton target at five CM angles (76 0 ,85 0 ,98 0 ,115 0 ,132 0 ). The experimental results are compared with different predictions. A Faddeev type calculation on the basis of local potentials also including approximate Coulomb distortion is favoured by our experimental results. (orig.)

  1. PolarHub: A Global Hub for Polar Data Discovery

    Science.gov (United States)

    Li, W.

    2014-12-01

    This paper reports the outcome of a NSF project in developing a large-scale web crawler PolarHub to discover automatically the distributed polar dataset in the format of OGC web services (OWS) in the cyberspace. PolarHub is a machine robot; its goal is to visit as many webpages as possible to find those containing information about polar OWS, extract this information and store it into the backend data repository. This is a very challenging task given huge data volume of webpages on the Web. Three unique features was introduced in PolarHub to make it distinctive from earlier crawler solutions: (1) a multi-task, multi-user, multi-thread support to the crawling tasks; (2) an extensive use of thread pool and Data Access Object (DAO) design patterns to separate persistent data storage and business logic to achieve high extendibility of the crawler tool; (3) a pattern-matching based customizable crawling algorithm to support discovery of multi-type geospatial web services; and (4) a universal and portable client-server communication mechanism combining a server-push and client pull strategies for enhanced asynchronous processing. A series of experiments were conducted to identify the impact of crawling parameters to the overall system performance. The geographical distribution pattern of all PolarHub identified services is also demonstrated. We expect this work to make a major contribution to the field of geospatial information retrieval and geospatial interoperability, to bridge the gap between data provider and data consumer, and to accelerate polar science by enhancing the accessibility and reusability of adequate polar data.

  2. Waveguide elliptic polarizers for ECH at down-shifted frequencies on PLT

    International Nuclear Information System (INIS)

    Doane, J.L.

    1986-01-01

    ECH experiments on PLT with resonance frequencies of 80 to 90 GHz at the plasma center use 60 GHz extraordinary mode (X-mode) propagation at 30 0 from the toroidal field. Efficient excitation of this mode requires elliptic polarization of the incident wave at the plasma edge. On PLT the elliptic polarization is achieved outside the vacuum vessel in an elliptically deformed section of circular waveguide propagating TM11, a mode that is intermediate between TE01 and HE11 (which has an ideal radiation pattern). The squeeze and orientation of the TM11 polarizer are adjusted to compensate both for the birefringence of a corrugated bend propagating HE11 and for a flat mirror inside PLT that reverses the sense of rotation of the polarization. 11 refs., 8 figs

  3. Waveguide elliptic polarizers for ECH at down-shifted frequencies on PLT

    Energy Technology Data Exchange (ETDEWEB)

    Doane, J.L.

    1986-01-01

    ECH experiments on PLT with resonance frequencies of 80 to 90 GHz at the plasma center use 60 GHz extraordinary mode (X-mode) propagation at 30/sup 0/ from the toroidal field. Efficient excitation of this mode requires elliptic polarization of the incident wave at the plasma edge. On PLT the elliptic polarization is achieved outside the vacuum vessel in an elliptically deformed section of circular waveguide propagating TM11, a mode that is intermediate between TE01 and HE11 (which has an ideal radiation pattern). The squeeze and orientation of the TM11 polarizer are adjusted to compensate both for the birefringence of a corrugated bend propagating HE11 and for a flat mirror inside PLT that reverses the sense of rotation of the polarization. 11 refs., 8 figs.

  4. On the temperature dependence of the spontaneous polarization of lithium niobate and lithium tantalate

    International Nuclear Information System (INIS)

    Ismailzade, I.G.; Ismailov, R.M.

    1980-01-01

    The temperature dependence of spontaneous polarization Psub(s)(T) of LiNbO 3 and LiTaO 3 ferroelectrics is studied by the precision X-ray diffraction method up to the Curie temperature - 1140 and 650 deg C, respectively. It is shown that for LiTaO 3 a deviation from continuous variation of spontaneous polarization with temperature is observed, expressing itself more disticntly at temperatures corresponding to intermediate ferroelectric phase transitions. The Psub(s)(T) obtained has whown that up to 210 deg C the value of LiNbO 3 spontaneous polarization practically remains constant and it decreases with the temperature increase, and near the phase transition temperature (transition of the first order) Psub(s)(T) is 40% of spontaneous polarization at room temperature. As in the case of lithium tantalate stepwise changes of Psub(s)(T) for LiNbO 3 are observed

  5. CP-even and CP-odd transverse polarization of the electron in the muon decay

    International Nuclear Information System (INIS)

    Kuznetsov, A.V.

    1981-01-01

    In the most general weak interaction model with intermediate vector bosons, allowing CP breaking in the muon decay, CP- even and CP-odd transverse polarization of the μ-decay electrons is calculated taking into account the radiative corrections. It is shown that such corrections are essential only at the beginning of the spectrum reducing the observed transverse polarization effects. When the electron energy is close to its maximum and the emission angles are small, the transverse polarization considerably grows. Search for CP-even and CP-odd transverse polarization of the electrons should be carried out at energies Esub(e) approximately equal to O.975 Esub(e)sup(max) and emission angles THETA approximately equal to 25+35 deg [ru

  6. X-RAY VARIABILITY STUDY OF POLAR SCATTERED SEYFERT1 GALAXIES

    Directory of Open Access Journals (Sweden)

    Tobias Beuchert

    2014-08-01

    Full Text Available We study 12 Seyfert 1 galaxies with a high level of optical polarization. Optical light emerging from the innermost regions is predominantly scattered in a polar region above the central engine directly in our line of sight. These sources show characteristics of Seyfert 2 galaxies, e.g. polarized broad lines. The polarization signatures suggest a viewing angle of 45°, classifying them as intermediate Seyfert 1/2 types. The unified model predicts this line of sight to pass through the outer layer of the torus resulting in significant soft X-ray variability due to a strongly varying column density. The aim is to find evidence for this geometrical assumption in the spectral variability of all available historical observations of these sources by XMM-Newton and Swift.

  7. One-stage correction of intermediate imperforate anus in males ...

    African Journals Online (AJOL)

    Background: This prospective study was designed to assess the safety, cost effectiveness, and advantages of performing posterior sagittal anorectoplasty without colostomy on males with intermediate imperforate anus. Method: Five consecutive males with intermediate imperforate anus were entered into the study.

  8. Intermediate temperature solid oxide fuel cells.

    Science.gov (United States)

    Brett, Daniel J L; Atkinson, Alan; Brandon, Nigel P; Skinner, Stephen J

    2008-08-01

    High temperature solid oxide fuel cells (SOFCs), typified by developers such as Siemens Westinghouse and Rolls-Royce, operate in the temperature region of 850-1000 degrees C. For such systems, very high efficiencies can be achieved from integration with gas turbines for large-scale stationary applications. However, high temperature operation means that the components of the stack need to be predominantly ceramic and high temperature metal alloys are needed for many balance-of-plant components. For smaller scale applications, where integration with a heat engine is not appropriate, there is a trend to move to lower temperatures of operation, into the so-called intermediate temperature (IT) range of 500-750 degrees C. This expands the choice of materials and stack geometries that can be used, offering reduced system cost and, in principle, reducing the corrosion rate of stack and system components. This review introduces the IT-SOFC and explains the advantages of operation in this temperature regime. The main advances made in materials chemistry that have made IT operation possible are described and some of the engineering issues and the new opportunities that reduced temperature operation affords are discussed. This tutorial review examines the advances being made in materials and engineering that are allowing solid oxide fuel cells to operate at lower temperature. The challenges and advantages of operating in the so-called 'intermediate temperature' range of 500-750 degrees C are discussed and the opportunities for applications not traditionally associated with solid oxide fuel cells are highlighted. This article serves as an introduction for scientists and engineers interested in intermediate temperature solid oxide fuel cells and the challenges and opportunities of reduced temperature operation.

  9. Intermediate Energy Activation File (IEAF-99)

    International Nuclear Information System (INIS)

    Korovin, Yu.; Konobeev, A.; Pereslavtsev, P.; Stankovskij, A.; Fischer, U.; Moellendorff, U. von

    1999-01-01

    Nuclear data library IEAF-99, elaborated to study processes of interactions of intermediate energy neutrons with materials in accelerator driven systems, is described. The library is intended for activation and transmutation studies for materials irradiated by neutrons. IEAF-99 contains evaluated neutron induced reaction cross sections at the energies 0-150 MeV for 665 stable and unstable nuclei from C to Po. Approximately 50,000 excitation functions are included in the library. The IEAF-99 data are written in the ENDF-6 format combining MF = 3,6 MT = 5 data recording. (author)

  10. Thermoelectric power generator with intermediate loop

    Science.gov (United States)

    Bell, Lon E; Crane, Douglas Todd

    2013-05-21

    A thermoelectric power generator is disclosed for use to generate electrical power from heat, typically waste heat. An intermediate heat transfer loop forms a part of the system to permit added control and adjustability in the system. This allows the thermoelectric power generator to more effectively and efficiently generate power in the face of dynamically varying temperatures and heat flux conditions, such as where the heat source is the exhaust of an automobile, or any other heat source with dynamic temperature and heat flux conditions.

  11. MHD oxidant intermediate temperature ceramic heater study

    Science.gov (United States)

    Carlson, A. W.; Chait, I. L.; Saari, D. P.; Marksberry, C. L.

    1981-09-01

    The use of three types of directly fired ceramic heaters for preheating oxygen enriched air to an intermediate temperature of 1144K was investigated. The three types of ceramic heaters are: (1) a fixed bed, periodic flow ceramic brick regenerative heater; (2) a ceramic pebble regenerative heater. The heater design, performance and operating characteristics under conditions in which the particulate matter is not solidified are evaluated. A comparison and overall evaluation of the three types of ceramic heaters and temperature range determination at which the particulate matter in the MHD exhaust gas is estimated to be a dry powder are presented.

  12. Intermediate Bandgap Solar Cells From Nanostructured Silicon

    Energy Technology Data Exchange (ETDEWEB)

    Black, Marcie [Bandgap Engineering, Lincoln, MA (United States)

    2014-10-30

    This project aimed to demonstrate increased electronic coupling in silicon nanostructures relative to bulk silicon for the purpose of making high efficiency intermediate bandgap solar cells using silicon. To this end, we formed nanowires with controlled crystallographic orientation, small diameter, <111> sidewall faceting, and passivated surfaces to modify the electronic band structure in silicon by breaking down the symmetry of the crystal lattice. We grew and tested these silicon nanowires with <110>-growth axes, which is an orientation that should produce the coupling enhancement.

  13. Polar source analysis : technical memorandum

    Science.gov (United States)

    2017-09-29

    The following technical memorandum describes the development, testing and analysis of various polar source data sets. The memorandum also includes recommendation for potential inclusion in future releases of AEDT. This memorandum is the final deliver...

  14. Anodic Concentration Polarization in SOFCs

    Energy Technology Data Exchange (ETDEWEB)

    Williford, Rick E.; Chick, Lawrence A.; Maupin, Gary D.; Simner, Steve P.; Stevenson, Jeffry W.; Khaleel, Mohammad A.; Wachsman, ED, et al

    2003-08-01

    Concentration polarization is important because it determines the maximum power output of a solid oxide fuel cell (SOFC) at high fuel utilization. Anodic concentration polarization occurs when the demand for reactants exceeds the capacity of the porous ceramic anode to supply them by gas diffusion mechanisms. High tortuosities (bulk diffusion resistances) are often assumed to explain this behavior. However, recent experiments show that anodic concentration polarization originates in the immediate vicinity of the reactive triple phase boundary (TPB) sites near the anode/electrolyte interface. A model is proposed to describe how concentration polarization is controlled by two localized phenomena: competitive adsorption of reactants in areas adjacent to the reactive TPB sites, followed by relatively slow surface diffusion to the reactive sites. Results suggest that future SOFC design improvements should focus on optimization of the reactive area, adsorption, and surface diffusion at the anode/electrolyte interface.

  15. The definition of cross polarization

    DEFF Research Database (Denmark)

    Ludwig, Arthur

    1973-01-01

    There are at least three different definitions of cross polarization used in the literature. The alternative definitions are discussed with respect to several applications, and the definition which corresponds to one standard measurement practice is proposed as the best choice....

  16. Dynamic elections and ideological polarization

    Czech Academy of Sciences Publication Activity Database

    Nunnari, S.; Zápal, Jan

    2017-01-01

    Roč. 25, č. 4 (2017), s. 505-534 ISSN 1047-1987 Institutional support: Progres-Q24 Keywords : elections * political polarization Subject RIV: AH - Economics OBOR OECD: Economic Theory Impact factor: 3.361, year: 2016

  17. Dynamic elections and ideological polarization

    Czech Academy of Sciences Publication Activity Database

    Nunnari, S.; Zápal, Jan

    2017-01-01

    Roč. 25, č. 4 (2017), s. 505-534 ISSN 1047-1987 Institutional support: RVO:67985998 Keywords : elections * political polarization Subject RIV: AH - Economics OBOR OECD: Economic Theory Impact factor: 3.361, year: 2016

  18. Polarization at LEP. Vol. 2

    International Nuclear Information System (INIS)

    Alexander, G.; Altarelli, G.; Blondel, A.; Coignet, G.; Keil, E.; Plane, D.E.; Treille, D.

    1988-01-01

    This report contains a collection of papers covering the most important part of studies carried out by five study groups in view of a programme of experiments with polarized beams at LEP, the Large Electron-Positron collider under construction at CERN. The emphasis is on precision measurements at the Z peak. Such measurements are shown to be of considerable theoretical interest as well as very clean from the point of view of theoretical and experimental uncertainties. The measurement of the beam polarization can certainly be performed with sufficient accuracy, thanks to the availability of both e + and e - beam polarization. The normalization of the data taken with different beam helicities poses certain constraints that are described. Substantial progress has been made in understanding the possibility of providing longitudinally polarized beams in the LEP machine: The design of new wigglers and spin rotators, the study of correction procedures and results of numerical simulations are presented. (orig.)

  19. Mechanical writing of ferroelectric polarization.

    Science.gov (United States)

    Lu, H; Bark, C-W; Esque de los Ojos, D; Alcala, J; Eom, C B; Catalan, G; Gruverman, A

    2012-04-06

    Ferroelectric materials are characterized by a permanent electric dipole that can be reversed through the application of an external voltage, but a strong intrinsic coupling between polarization and deformation also causes all ferroelectrics to be piezoelectric, leading to applications in sensors and high-displacement actuators. A less explored property is flexoelectricity, the coupling between polarization and a strain gradient. We demonstrate that the stress gradient generated by the tip of an atomic force microscope can mechanically switch the polarization in the nanoscale volume of a ferroelectric film. Pure mechanical force can therefore be used as a dynamic tool for polarization control and may enable applications in which memory bits are written mechanically and read electrically.

  20. Mechanical Writing of Ferroelectric Polarization

    Science.gov (United States)

    Lu, H.; Bark, C.-W.; Esque de los Ojos, D.; Alcala, J.; Eom, C. B.; Catalan, G.; Gruverman, A.

    2012-04-01

    Ferroelectric materials are characterized by a permanent electric dipole that can be reversed through the application of an external voltage, but a strong intrinsic coupling between polarization and deformation also causes all ferroelectrics to be piezoelectric, leading to applications in sensors and high-displacement actuators. A less explored property is flexoelectricity, the coupling between polarization and a strain gradient. We demonstrate that the stress gradient generated by the tip of an atomic force microscope can mechanically switch the polarization in the nanoscale volume of a ferroelectric film. Pure mechanical force can therefore be used as a dynamic tool for polarization control and may enable applications in which memory bits are written mechanically and read electrically.

  1. Modeling optical and UV polarization of AGNs. IV. Polarization timing

    Science.gov (United States)

    Rojas Lobos, P. A.; Goosmann, R. W.; Marin, F.; Savić, D.

    2018-03-01

    Context. Optical observations cannot resolve the structure of active galactic nuclei (AGN), and a unified model for AGN was inferred mostly from indirect methods, such as spectroscopy and variability studies. Optical reverberation mapping allowed us to constrain the spatial dimension of the broad emission line region and thereby to measure the mass of supermassive black holes. Recently, reverberation was also applied to the polarized signal emerging from different AGN components. In principle, this should allow us to measure the spatial dimensions of the sub-parsec reprocessing media. Aim. We conduct numerical modeling of polarization reverberation and provide theoretical predictions for the polarization time lag induced by different AGN components. The model parameters are adjusted to the observational appearance of the Seyfert 1 galaxy NGC 4151. Methods: We modeled scattering-induced polarization and tested different geometries for the circumnuclear dust component. Our tests included the effects of clumpiness and different dust prescriptions. To further extend the model, we also explored the effects of additional ionized winds stretched along the polar direction, and of an equatorial scattering ring that is responsible for the polarization angle observed in pole-on AGN. The simulations were run using a time-dependent version of the STOKES code. Results: Our modeling confirms the previously found polarization characteristics as a function of the observer`s viewing angle. When the dust adopts a flared-disk geometry, the lags reveal a clear difference between type 1 and type 2 AGN. This distinction is less clear for a torus geometry where the time lag is more sensitive to the geometry and optical depth of the inner surface layers of the funnel. The presence of a scattering equatorial ring and ionized outflows increased the recorded polarization time lags, and the polar outflows smooths out dependence on viewing angle, especially for the higher optical depth of the

  2. 40 CFR 721.983 - Sulfonyl azide intermediate (generic).

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Sulfonyl azide intermediate (generic... Substances § 721.983 Sulfonyl azide intermediate (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as sulfonyl azide intermediate...

  3. Surface Intermediate Zone of Submerged Turbulent Buoyant Jet in Current

    DEFF Research Database (Denmark)

    Chen, H. B.; Larsen, Torben

    1995-01-01

    This paper deals with the intermediate zone between the jet and plume stages of a submerged buoyant discharge from sea outfall in current. The stability criteria, plume width and height after the intermediate zone and the dilution within the intermediate region have been studied theoretically...

  4. Intermediate product selection and blending in the food processing industry

    DEFF Research Database (Denmark)

    Kilic, Onur A.; Akkerman, Renzo; van Donk, Dirk Pieter

    2013-01-01

    This study addresses a capacitated intermediate product selection and blending problem typical for two-stage production systems in the food processing industry. The problem involves the selection of a set of intermediates and end-product recipes characterising how those selected intermediates...

  5. 42 CFR 54.12 - Treatment of intermediate organizations.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Treatment of intermediate organizations. 54.12... intermediate organizations. If a nongovernmental organization (referred to here as an “intermediate organization”), acting under a contract or other agreement with the Federal Government or a State or local...

  6. 40 CFR 86.246-94 - Intermediate temperature testing.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Intermediate temperature testing. 86... New Medium-Duty Passenger Vehicles; Cold Temperature Test Procedures § 86.246-94 Intermediate temperature testing. (a) This section is applicable to tests which are conducted at an intermediate...

  7. Solid Polarized Targets and Applications

    International Nuclear Information System (INIS)

    Crabb, D. G.

    2008-01-01

    Examples are given of dynamically polarized targets in use today and how the subsystems have changed to meet the needs of todays experiments. Particular emphasis is placed on target materials such as ammonia and lithium deuteride. Recent polarization studies of irradiated materials such as butanol, deuterated butanol, polyethylene, and deuterated polyethylene are presented. The operation of two non-DNP target systems as well as applications of traditional DNP targets are briefly discussed

  8. Artificial anisotropy and polarizing filters.

    Science.gov (United States)

    Flory, François; Escoubas, Ludovic; Lazaridès, Basile

    2002-06-01

    The calculated spectral transmittance of a multilayer laser mirror is used to determine the effective index of the single layer equivalent to the multilayer stack. We measure the artificial anisotropy of photoresist thin films whose structure is a one-dimensional, subwavelength grating obtained from interference fringes. The limitation of the theory of the first-order effective index homogenization is discussed. We designed normal-incidence, polarizing coating and a polarization rotator by embedding anisotropic films in simple multilayer structures.

  9. Polarization bremsstrahlung in α decay

    International Nuclear Information System (INIS)

    Amusia, M. Ya.; Zon, B. A.; Kretinin, I. Yu.

    2007-01-01

    A mechanism of formation of electromagnetic radiation that accompanies α decay and is associated with the emission of photons by electrons of atomic shells due to the scattering of α particles by these atoms (polarization bremsstrahlung) is proposed. It is shown that, when the photon energy is no higher than the energy of K electrons of an atom, polarization bremsstrahlung makes a significant contribution to the bremsstrahlung in α decay

  10. Coherent states with elliptical polarization

    OpenAIRE

    Colavita, E.; Hacyan, S.

    2004-01-01

    Coherent states of the two dimensional harmonic oscillator are constructed as superpositions of energy and angular momentum eigenstates. It is shown that these states are Gaussian wave-packets moving along a classical trajectory, with a well defined elliptical polarization. They are coherent correlated states with respect to the usual cartesian position and momentum operators. A set of creation and annihilation operators is defined in polar coordinates, and it is shown that these same states ...

  11. Polarization of Coronal Forbidden Lines

    Energy Technology Data Exchange (ETDEWEB)

    Li, Hao; Qu, Zhongquan [Yunnan Observatories, Chinese Academy of Sciences, Kunming, Yunnan 650011 (China); Landi Degl’Innocenti, Egidio, E-mail: sayahoro@ynao.ac.cn [Dipartimento di Astronomia e Scienza dello Spazio, Università di Firenze, Largo E. Fermi 2, I-50125 Firenze (Italy)

    2017-03-20

    Since the magnetic field is responsible for most manifestations of solar activity, one of the most challenging problems in solar physics is the diagnostics of solar magnetic fields, particularly in the outer atmosphere. To this end, it is important to develop rigorous diagnostic tools to interpret polarimetric observations in suitable spectral lines. This paper is devoted to analyzing the diagnostic content of linear polarization imaging observations in coronal forbidden lines. Although this technique is restricted to off-limb observations, it represents a significant tool to diagnose the magnetic field structure in the solar corona, where the magnetic field is intrinsically weak and still poorly known. We adopt the quantum theory of polarized line formation developed in the framework of the density matrix formalism, and synthesize images of the emergent linear polarization signal in coronal forbidden lines using potential-field source-surface magnetic field models. The influence of electronic collisions, active regions, and Thomson scattering on the linear polarization of coronal forbidden lines is also examined. It is found that active regions and Thomson scattering are capable of conspicuously influencing the orientation of the linear polarization. These effects have to be carefully taken into account to increase the accuracy of the field diagnostics. We also found that linear polarization observation in suitable lines can give valuable information on the long-term evolution of the magnetic field in the solar corona.

  12. Polarization in free electron lasers

    Energy Technology Data Exchange (ETDEWEB)

    Papadichev, V.A. [Lebedev Physical Institute, Moscow (Russian Federation)

    1995-12-31

    Polarization of electromagnetic radiation is required very often in numerous scientific and industrial applications: studying of crystals, molecules and intermolecular interaction high-temperature superconductivity, semiconductors and their transitions, polymers and liquid crystals. Using polarized radiation allows to obtain important data (otherwise inaccessible) in astrophysics, meteorology and oceanology. It is promising in chemistry and biology for selective influence on definite parts of molecules in chain synthesis reactions, precise control of various processes at cell and subcell levels, genetic engineering etc. Though polarization methods are well elaborated in optics, they can fail in far-infrared, vacuum-ultraviolet and X-ray regions because of lack of suitable non-absorbing materials and damaging of optical elements at high specific power levels. Therefore, it is of some interest to analyse polarization of untreated FEL radiation obtained with various types of undulators, with and without axial magnetic field. The polarization is studied using solutions for electron orbits in various cases: plane or helical undulator with or without axial magnetic field, two plane undulators, a combination of right- and left-handed helical undulators with equal periods, but different field amplitudes. Some examples of how a desired polarization (elliptical circular or linear) can be obtained or changed quickly, which is necessary in many experiments, are given.

  13. Can Morphing Methods Predict Intermediate Structures?

    Science.gov (United States)

    Weiss, Dahlia R.; Levitt, Michael

    2009-01-01

    Movement is crucial to the biological function of many proteins, yet crystallographic structures of proteins can give us only a static snapshot. The protein dynamics that are important to biological function often happen on a timescale that is unattainable through detailed simulation methods such as molecular dynamics as they often involve crossing high-energy barriers. To address this coarse-grained motion, several methods have been implemented as web servers in which a set of coordinates is usually linearly interpolated from an initial crystallographic structure to a final crystallographic structure. We present a new morphing method that does not extrapolate linearly and can therefore go around high-energy barriers and which can produce different trajectories between the same two starting points. In this work, we evaluate our method and other established coarse-grained methods according to an objective measure: how close a coarse-grained dynamics method comes to a crystallographically determined intermediate structure when calculating a trajectory between the initial and final crystal protein structure. We test this with a set of five proteins with at least three crystallographically determined on-pathway high-resolution intermediate structures from the Protein Data Bank. For simple hinging motions involving a small conformational change, segmentation of the protein into two rigid sections outperforms other more computationally involved methods. However, large-scale conformational change is best addressed using a nonlinear approach and we suggest that there is merit in further developing such methods. PMID:18996395

  14. Intermediate heat exchanger project for Super Phenix

    International Nuclear Information System (INIS)

    Roumailhac, J.; Desir, D.

    1975-01-01

    The Super Phenix (1200 MWe) intermediate heat exchangers are derived directly from those of Phenix (250 MWe). The intermediate exchangers are housed in the reactor vessel annulus: as this annulus must be of the smallest volume possible, these IHX are required to work at a high specific rating. The exchange surface is calculated for nominal conditions. A range is then defined, consistent with the above requirements and throughout which the ratio between bundle thickness and bundle length remains acceptable. Experimental technics and calculations were used to determine the number of tube constraint systems required to keep the vibration amplitude within permissible limits. From a knowledge of this number, the pressure drop produced by the primary flow can be calculated. The bundle geometry is determined together with the design of the corresponding tube plates and the way in which these plates should be joined to the body of the IHX. The experience (technical and financial) acquired in the construction of Phenix is then used to optimize the design of the Super Phenix project. An approximate definition of the structure of the IHX is obtained by assuming a simplified load distribution in the calculations. More sophisticated calculations (e.g. finite element method) are then used to determine the behaviour of the different points of the IHX, under nominal and transient conditions

  15. Sequential double photodetachment of He- in elliptically polarized laser fields

    Science.gov (United States)

    Génévriez, Matthieu; Dunseath, Kevin M.; Terao-Dunseath, Mariko; Urbain, Xavier

    2018-02-01

    Four-photon double detachment of the helium negative ion is investigated experimentally and theoretically for photon energies where the transient helium atom is in the 1 s 2 s 3S or 1 s 2 p P3o states, which subsequently ionize by absorption of three photons. Ionization is enhanced by intermediate resonances, giving rise to series of peaks in the He+ spectrum, which we study in detail. The He+ yield is measured in the wavelength ranges from 530 to 560 nm and from 685 to 730 nm and for various polarizations of the laser light. Double detachment is treated theoretically as a sequential process, within the framework of R -matrix theory for the first step and effective Hamiltonian theory for the second step. Experimental conditions are accurately modeled, and the measured and simulated yields are in good qualitative and, in some cases, quantitative agreement. Resonances in the double detachment spectra can be attributed to well-defined Rydberg states of the transient atom. The double detachment yield exhibits a strong dependence on the laser polarization which can be related to the magnetic quantum number of the intermediate atomic state. We also investigate the possibility of nonsequential double detachment with a two-color experiment but observe no evidence for it.

  16. The intermediate endpoint effect in logistic and probit regression

    Science.gov (United States)

    MacKinnon, DP; Lockwood, CM; Brown, CH; Wang, W; Hoffman, JM

    2010-01-01

    Background An intermediate endpoint is hypothesized to be in the middle of the causal sequence relating an independent variable to a dependent variable. The intermediate variable is also called a surrogate or mediating variable and the corresponding effect is called the mediated, surrogate endpoint, or intermediate endpoint effect. Clinical studies are often designed to change an intermediate or surrogate endpoint and through this intermediate change influence the ultimate endpoint. In many intermediate endpoint clinical studies the dependent variable is binary, and logistic or probit regression is used. Purpose The purpose of this study is to describe a limitation of a widely used approach to assessing intermediate endpoint effects and to propose an alternative method, based on products of coefficients, that yields more accurate results. Methods The intermediate endpoint model for a binary outcome is described for a true binary outcome and for a dichotomization of a latent continuous outcome. Plots of true values and a simulation study are used to evaluate the different methods. Results Distorted estimates of the intermediate endpoint effect and incorrect conclusions can result from the application of widely used methods to assess the intermediate endpoint effect. The same problem occurs for the proportion of an effect explained by an intermediate endpoint, which has been suggested as a useful measure for identifying intermediate endpoints. A solution to this problem is given based on the relationship between latent variable modeling and logistic or probit regression. Limitations More complicated intermediate variable models are not addressed in the study, although the methods described in the article can be extended to these more complicated models. Conclusions Researchers are encouraged to use an intermediate endpoint method based on the product of regression coefficients. A common method based on difference in coefficient methods can lead to distorted

  17. Superconducting polarizing magnet for a movable polarized target

    International Nuclear Information System (INIS)

    Anishchenko, N.G.; Bartenev, V.D.; Blinov, N.A.

    1998-01-01

    The superconducting polarizing magnet was constructed for the JINR (Dubna) movable polarized target (MPT) with working volume 200 mm long and 30 mm in diameter. The magnet provides a polarizing magnetic field up to 6 T in the centre with the uniformity of 4.5 x 10 -4 in the working volume of the target. The magnet contains a main solenoidal winding 558 mm long and 206/144 mm in diameters, and compensating and correcting winding placed at its ends. The windings are made of a NbTi wire, impregnated with the epoxy resin and placed in the horizontal cryostat. The diameter of the 'warm' aperture of the magnet cryostat is 96 mm. The design and technology of the magnet winding are described. Results of the magnetic field map measurements, using a NMR-magnetometer are given. A similar magnet constructed at DAPNIA, CEA/Saclay (France), represented a model for the present development. The MPT array is installed in the beam line of polarized neutrons produced by break-up of polarized deuterons extracted from the synchrophasotron of the Laboratory of High Energies (LHE), JINR (Dubna)

  18. Cross-polarization characterization of GORE—TEX© at ALMA band 9 frequencies

    Science.gov (United States)

    Candotti, M.; Baryshev, A. M.; Trappe, N. A.; Hesper, R.; Murphy, J. A.; Barkhol, J.

    2006-05-01

    GORE-TEX material, commonly used in radomes, is known to be transparent at microwave bands. In ALMA a thin GORE-TEX membrane will cover the aperture through which the RF beam enters the cabin at the primary vertex hole. Slabs of GORE-TEX are also generally employed in windows for intermediate temperature shields inside the cryostat. The purpose of these windows ideally is to allow the beam to pass through them without introducing any alteration to the beam properties. The main concern is RF loss, but also cross-polarization efficiency degradation. This paper will concentrate on the results we have obtained for ALMA band 9 (602-720 GHz), in relation of loss of cross-polarization efficiency of a linearly polarized beam passing through a GORE-TEX slab, depending on its orientation relative to the direction of polarization of the beam. In order to spot anisotropic behavior of the material under test, an ad hoc measurements set-up has been used. Systematic measurements of cross-polarization properties for different thicknesses of GORE-TEX slabs were undertaken. Cross-polarization information is given in relation of the relative angle between the incident beam polarization and the material under test.

  19. Fast and accurate measurement of on-axis gain and on-axis polarization at a finite distance

    DEFF Research Database (Denmark)

    Pivnenko, S.; Breinbjerg, O.

    2013-01-01

    to reduce the amount of measurement data and thus measurement time, the phase centre location is found on a sparse frequency grid and the values in the intermediate points are found by interpolation. The antenna polarization is determined from the amplitude/phase frequency sweeps with two orthogonal AUT...

  20. Polarization fluctuations in stationary light beams

    International Nuclear Information System (INIS)

    Shevchenko, A.; Setaelae, T.; Kaivola, M.; Friberg, A.T.; Royal Institute of Technology , Department of Microelectronics and Applied Physics; Sweden)

    2009-01-01

    For stationary beams the degree of polarization contains only limited information on time dependent polarization. Two approaches towards assessing a beams polarization dynamics, one based on Poincare and the other on Jones vector formalism, are described leading to the notion of polarization time. Specific examples of partially temporally coherent electromagnetic beams are discussed. (Author)

  1. FIRST POLARIZED PROTON COLLISIONS AT RHIC

    International Nuclear Information System (INIS)

    ROSER, T.; AHRENS, L.; ALESSI, J.; BAI, M.; BEEBE-WANG, J.; BRENNAN, J.M.; BROWN, K.A.; BUNCE, G.; CAMERON, P.; COURANT, E.D.; DREES, A.; FISCHER, W.; FLILLER, R. III; GLENN, W.; HUANG, H.; LUCCIO, A.U.; MACKAY, W.W.; MAKDISI, Y.; MONTAG, C.; PILAT, F.; PTITSYN, V.; SATOGATA, T.

    2002-01-01

    We successfully injected polarized protons in both RHIC rings and maintained polarization during acceleration up to 100 GeV per ring using two Siberian snakes in each ring. Each snake consists of four helical superconducting dipoles which rotate the polarization by 180 o about a horizontal axis. This is the first time that polarized protons have been accelerated to 100 GeV

  2. Apico-basal polarity complex and cancer

    Indian Academy of Sciences (India)

    Apico-basal polarity is a cardinal molecular feature of adult eukaryotic epithelial cells and appears to be involved in several key cellular processes including polarized cell migration and maintenance of tissue architecture. Epithelial cell polarity is maintained by three well-conserved polarity complexes, namely, PAR, Crumbs ...

  3. The P9 pocket of HLA-DQ2 (non-Aspbeta57) has no particular preference for negatively charged anchor residues found in other type 1 diabetes-predisposing non-Aspbeta57 MHC class II molecules

    DEFF Research Database (Denmark)

    Quarsten, H; Paulsen, G; Johansen, B H

    1998-01-01

    Susceptibility and resistance to type 1 diabetes are associated with MHC class II alleles that carry non-Asp and Asp at residue 57 of their beta chain respectively. The effect of Asp or non-Aspbeta57 may relate to a differential ability of distinct class II molecules to bind specific immuno......-pathogenic peptides. Recent studies in man and mouse have revealed that some type 1 diabetes-predisposing non-Aspbeta57 class II molecules (i.e. DQ8, DR4Dw15 and I-Ag7) preferentially bind peptides with a negatively charged anchor residue at P9. It has been suggested that this is a common feature of type 1 diabetes......-predisposing class II molecules. The molecular explanation for such a phenomenon could be that class II beta chains with Aspbeta57 form a salt bridge between Aspbeta57 and a conserved Arg of the a chain, whereas in non-Aspbeta57 molecules the Arg is unopposed and free to interact with negatively charged P9 peptide...

  4. Inclusive quasielastic scattering of polarized electrons from polarized nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Amaro, J.E. [Massachusetts Inst. of Tech., Cambridge, MA (United States). Center for Theoretical Physics]|[Universidad de Granada (Spain). Dept. de Fisica Moderna]|[Massachusetts Inst. of Tech., Cambridge, MA (United States). Lab. for Nuclear Science]|[Massachusetts Inst. of Tech., Cambridge, MA (United States). Dept. of Physics; Caballero, J.A. [Consejo Superior de Investigaciones Cientificas (CSIC), Madrid (Spain). Inst. de Estructura de la Materia]|[Sevilla Univ. (Spain). Dept. de Fisica Atomica, Molecular y Nuclear; Donnelly, T.W. [Massachusetts Inst. of Tech., Cambridge, MA (United States). Center for Theoretical Physics]|[Massachusetts Inst. of Tech., Cambridge, MA (United States). Lab. for Nuclear Science]|[Massachusetts Inst. of Tech., Cambridge, MA (United States). Dept. of Physics; Moya de Guerra, E. [Consejo Superior de Investigaciones Cientificas (CSIC), Madrid (Spain). Inst. de Estructura de la Materia

    1996-12-23

    The inclusive quasielastic response functions that appear in the scattering of polarized electrons from polarized nuclei are computed and analyzed for several closed-shell-minus-one nuclei with special attention paid to {sup 39}K. Results are presented using two models for the ejected nucleon - when described by a distorted wave in the continuum shell model or by a plane wave in PWIA with on- and off-shell nucleons. Relativistic effects in kinematics and in the electromagnetic current have been incorporated throughout. Specifically, the recently obtained expansion of the electromagnetic current in powers only of the struck nucleon`s momentum is employed for the on-shell current and the effects of the first-order terms (spin-orbit and convection) are compared with the zeroth-order (charge and magnetization) contributions. The use of polarized inclusive quasielastic electron scattering as a tool for determining near-valence nucleon momentum distributions is discussed. (orig.).

  5. System for measuring of proton polarization in polarized target

    International Nuclear Information System (INIS)

    Derkach, A.Ya.; Lukhanin, A.A.; Karnaukhov, I.M.; Kuz'menko, V.S.; Telegin, Yu.N.; Trotsenko, V.I.; Chechetenko, V.F.

    1981-01-01

    Measurement system of proton polarization in the target, which uses the method of nuclear magnetic resonance is described. To record the signal of NMR-absorption a parallel Q-meter of voltage with analogous subtraction of resonance characteristics of measurement circuit is used. To obtain gradual sensitivity of the system to polarization state in the whole volume of the target the measurement coils is made of tape conductor. The analysis and mathematical modelling of Q-meter are carried out. Corrections for nonlinearity and dispersion are calculated. Key diagrams of the main electron blocks of Q-meter are presented. The system described operates on line with the M6000 computer. Total error of measurement of polarization value of free protons in the target does not exceed 6% [ru

  6. System of measurement of proton polarization in a polarized target

    Energy Technology Data Exchange (ETDEWEB)

    Karnaukov, I.M.; Chechetenko, V.F.; Lukhanin, A.A.; Telegin, Y.N.; Trotsenko, V.I.

    1985-05-01

    This paper describes a nuclear magnetic resonance spectrometer with high sensitivity. The signal of NMR absorption is recorded by a Q-meter with a series circuit and a circuit for compensation of the resonance characteristic of the measuring circuit. In order to ensure uniform sensitivity of the system to the state of polarization throughout the volume of the target and to enhance the S/N ration the measuring coil is made of a flat conductor. The polarization-measuring system works on-line with an M-6000 computer. The total error of measurement of the polarization of free protons in a target with allowance for the error due to local depolarization of free protons in a target with allowance for the error due to local depolarization of the working substance under irradiation with an intense photon beam is less than or equal to 6%.

  7. Dust Evolution in Intermediate Velocity Clouds

    Science.gov (United States)

    Pinheiro Gonçalves, D.; Martin, P. G.; Blagrave, K.; Miville-Deschenes, M. A.

    We search for evidence of dust evolution in high Galactic latitude regions by looking at variations in the emissivities of dust associated with different velocity clouds. In order to do so, we spatially correlate infrared IRAS/IRIS dust maps with HI column density maps derived from 21-cm radio observations with the GBT. Our findings show that intermediate velocity clouds (IVCs or halo clouds) have a higher 60µm/100µm and lower 12µm/100µm color ratio when compared to dust in local low-velocity gas. This suggests that large thermal dust grains are shattered into smaller ones (VSGs) and that there is a low relative abundance of PAHs in IVCs.

  8. Slab tears and intermediate-depth seismicity

    Science.gov (United States)

    Meighan, Hallie E.; ten Brink, Uri S.; Pulliam, Jay

    2013-01-01

    Active tectonic regions where plate boundaries transition from subduction to strike slip can take several forms, such as triple junctions, acute, and obtuse corners. Well-documented slab tears that are associated with high rates of intermediate-depth seismicity are considered here: Gibraltar arc, the southern and northern ends of the Lesser Antilles arc, and the northern end of Tonga trench. Seismicity at each of these locations occurs, at times, in the form of swarms or clusters, and various authors have proposed that each marks an active locus of tear propagation. The swarms and clusters start at the top of the slab below the asthenospheric wedge and extend 30–60 km vertically downward within the slab. We propose that these swarms and clusters are generated by fluid-related embrittlement of mantle rocks. Focal mechanisms of these swarms generally fit the shear motion that is thought to be associated with the tearing process.

  9. Intermediate normal metal layers in superconducting circuitry

    International Nuclear Information System (INIS)

    Sweeney, M.F.; Gershenson, M.; Fleming, D.L.; Barta, R.E.

    1987-01-01

    This patent describes a superconducting device comprising a first superconducting layer, a junction layer on the first superconducting layer, an insulating layer on the first superconducting layer, at least one superconducting area on the junction layer surrounded by the insulator layer, superconducting connector pad means disposed over the superconducting area, and superconducting wire means electrically connected to the superconducting connector pad means. The improvement comprising a first metal layer is disposed over the insulator layer and intermediate the superconducting area. The connector pad means and a second metal layer are disposed between the connector pad means and the superconductor wire means. The first metal layer covers the superconducting area and the first and second metal layers are sufficiently thin to allow quantum mechanical tunneling between the connector pad means and the superconducting area and the connector pad means and the superconducting wire means, respectively

  10. Modernisation of the intermediate physics laboratory

    Science.gov (United States)

    Kontro, Inkeri; Heino, Olga; Hendolin, Ilkka; Galambosi, Szabolcs

    2018-03-01

    The intermediate laboratory courses at the Department of Physics, University of Helsinki, were reformed using desired learning outcomes as the basis for design. The reformed laboratory courses consist of weekly workshops and small-group laboratory sessions. Many of the laboratory exercises are open-ended and have several possible ways of execution. They were designed around affordable devices, to allow for the purchase of multiple sets of laboratory equipment. This allowed students to work on the same problems simultaneously. Thus, it was possible to set learning goals which build on each other. Workshop sessions supported the course by letting the students solve problems related to conceptual and technical aspects of each laboratory exercise. The laboratory exercises progressed biweekly to allow for iterative problem solving. Students reached the learning goals well and the reform improved student experiences. Neither positive or negative changes in expert-like attitudes towards experimental physics (measured by E-CLASS questionnaire) were observed.

  11. Melting of metallic intermediate level waste

    International Nuclear Information System (INIS)

    Huutoniemi, Tommi; Larsson, Arne; Blank, Eva

    2013-08-01

    This report presents a feasibility study of a melting facility for core components and reactor internals. An overview is given of how such a facility for treatment of intermediate level waste might be designed, constructed and operated and highlights both the possibilities and challenges. A cost estimate and a risk analysis are presented in order to make a conclusion of the technical feasibility of such a facility. Based on the authors' experience in operating a low level waste melting facility, their conclusion is that without technical improvements such a facility is not feasible today. This is based on the cost of constructing and operating such a facility, in conjunction with the radiological risks associated with operation and the uncertain benefits to disposal and long term safety

  12. Environmental issues of an intermediate city

    International Nuclear Information System (INIS)

    Ahmad, N.

    2005-01-01

    Our urban centers present a unique dimension of environmental problems. They are at one and the same time, enormous consumers of natural resources and produces of waste and pollution. In this respect intermediate cities and small towns appear to be more vulnerable to natural catastrophes and ecological accidents caused by human factors. While in large cities there exist pressure groups which attain government attention for the solution of their problems and have well equipped municipalities. However, a vast majority of the population lives in rural areas and depends upon medium sized cities and towns for access to services. These cities and towns form the pivot of economic, social, cultural and political life for a large part of the population. Therefore, it deserves more attention than bigger ones. This paper explores local people perception about urban environmental problems exist in the city. Attempts are also made to shape and guide municipality efforts to overcome such problems with available resources. (author)

  13. q-Gamow states for intermediate energies

    Energy Technology Data Exchange (ETDEWEB)

    Plastino, A. [La Plata National University and Argentina' s National Research Council, (IFLP-CCT-CONICET)-C. C. 727, 1900 La Plata (Argentina); Rocca, M.C., E-mail: mariocarlosrocca@gmail.com [La Plata National University and Argentina' s National Research Council, (IFLP-CCT-CONICET)-C. C. 727, 1900 La Plata (Argentina); Ferri, G.L. [Fac. de C. Exactas, National University La Pampa, Peru y Uruguay, Santa Rosa, La Pampa (Argentina); Zamora, D.J. [La Plata National University and Argentina' s National Research Council, (IFLP-CCT-CONICET)-C. C. 727, 1900 La Plata (Argentina)

    2016-11-15

    In a recent paper Plastino and Rocca (2016) [18] we have demonstrated the possible existence of Tsallis' q-Gamow states. Now, accelerators' experimental evidence for Tsallis' distributions has been ascertained only at very high energies. Here, instead, we develop a different set of q-Gamow states for which the associated q-Breit–Wigner distribution could easily be found at intermediate energies, for which accelerators are available at many locations. In this context, it should be strongly emphasized Vignat and Plastino (2009) [2] that, empirically, one never exactly and unambiguously “detects” pure Gaussians, but rather q-Gaussians. A prediction is made via Eq. (3.4).

  14. Being back home after intermediate care

    DEFF Research Database (Denmark)

    Martinsen, Bente; Harder, Ingegerd; Norlyk, Annelise

    2015-01-01

    Older people may face many challenges and experience insecurity after discharge from hospital to home. To bridge the potential gap between general hospital and home, the concept ‘Intermediate Care’ (IC) was developed at the beginning of 2000. IC aims to safeguard older people from being discharged...... to their home before they have sufficiently recovered, but knowledge within this area is sparse. In particular the experience of older people is yet to be explored. The aim of this study was to explore older people’s experiences of being back home after a stay in an IC unit. Data were drawn from 12 interviews....... Transcripts were analysed using a phenomenological approach. The essential meaning of being back home after a stay in an IC unit was characterised by ‘uncertainty’. Four constituents emerged: ‘in a state of shock about coming home’, ‘dependence on informal helpers’, ‘a sense of isolation’, and ‘fear of losing...

  15. Turned Back: Mad Men as Intermedial Melodrama

    Directory of Open Access Journals (Sweden)

    Monique Rooney

    2012-09-01

    Full Text Available This essay draws on definitions of gesture (Giorgio Agamben and Peter Brooks and catachresis (Peter Brooks, Jacques Derrida to examine the primacy of non-verbal signifiers as communicators of meaning in AMC’s Mad Men. Beginning with an analysis of Mad Men’s credit sequence, it draws attention to Mad Men’s use of gesture and catachresis in relation to melodrama’s privileging of non-verbal and naturalistic expression and its persistence as an intermedial mode that has moved back and forth between various media (theatre, novel, cinema, television and now digital formats. It argues that Mad Men’s melodramatic aesthetic is one that obliquely, and via a gestural and rhetorical ‘turned back’, communicates its relation to the past and the present.

  16. Treatment of low and intermediate level wastes

    International Nuclear Information System (INIS)

    Hoehlein, G.

    1978-05-01

    The methods described of low and intermediate level waste treatment are based exclusively on operating experience gathered with the KfK facilities for waste management, the Karlsruhe Reprocessing Plant (WAK), the ALKEM fuel element fabrication plant, the MZFR, KNK and FR 2 reactors as well as at the Karlsruhe Nuclear Research Center and at the state collecting depot of Baden-Wuerttemberg. The processing capacities and technical status are similar to that in 1976. With an annual throughput of 10000 m 3 of solid and liquid raw wastes, an aggregate activity of 85000 Ci, 500 kg of U and 2 kg of Pu, final waste in the amount of 500 m 3 was produced which was stored in the ASSE II salt mine. (orig.) [de

  17. Fission cross section measurements at intermediate energies

    International Nuclear Information System (INIS)

    Laptev, Alexander

    2005-01-01

    The activity in intermediate energy particle induced fission cross-section measurements of Pu, U isotopes, minor actinides and sub-actinides in PNPI of Russia is reviewed. The neutron-induced fission cross-section measurements are under way in the wide energy range of incident neutrons from 0.5 MeV to 200 MeV at the GNEIS facility. In number of experiments at the GNEIS facility, the neutron-induced fission cross sections were obtained for many nuclei. In another group of experiments the proton-induced fission cross-section have been measured for proton energies ranging from 200 to 1000 MeV at 100 MeV intervals using the proton beam of PNPI synchrocyclotron. (author)

  18. Melting of metallic intermediate level waste

    Energy Technology Data Exchange (ETDEWEB)

    Huutoniemi, Tommi; Larsson, Arne; Blank, Eva [Studsvik Nuclear AB, Nykoeping (Sweden)

    2013-08-15

    This report presents a feasibility study of a melting facility for core components and reactor internals. An overview is given of how such a facility for treatment of intermediate level waste might be designed, constructed and operated and highlights both the possibilities and challenges. A cost estimate and a risk analysis are presented in order to make a conclusion of the technical feasibility of such a facility. Based on the authors' experience in operating a low level waste melting facility, their conclusion is that without technical improvements such a facility is not feasible today. This is based on the cost of constructing and operating such a facility, in conjunction with the radiological risks associated with operation and the uncertain benefits to disposal and long term safety.

  19. On the Intermediate Line Region in AGNs

    Directory of Open Access Journals (Sweden)

    Tek P. Adhikari

    2017-09-01

    Full Text Available In this paper we explore the intermediate line region (ILR by using the photoionisation simulations of the gas clouds present at different radial distances from the center, corresponding to the locations from BLR out to NLR in four types of AGNs. We let for the presence of dust whenever conditions allow for dust existence. All spectral shapes are taken from the recent multi-wavelength campaigns. The cloud density decreases with distance as a power law. We found that the slope of the power law density profile does not affect the line emissivity radial profiles of major emission lines: Hβ, He II, Mg II, C III, and O III. When the density of the cloud at the sublimation radius is as high as 1011.5 cm−3, the ILR should clearly be seen in the observations independently of the shape of the illuminating radiation. Moreover, our result is valid for low ionization nuclear emission regions of active galaxies.

  20. Intermediate storage device of start accelerator

    International Nuclear Information System (INIS)

    Gaponenko, N.I.; Tkach, Yu.V.; Stepanenko, I.A.; Kozachek, A.S.; Komarov, A.D.; Gadetskii, N.P.

    1989-01-01

    The use as an intermediate storage device (ISD) of a chain of series-connected capacitors near the stages of a voltage-pulse generator (VPG) reduces the inductance of the VPG-ISD charging circuit and reduces the charging time to 330 nsec. For such times, the electric strength of the capacitor insulation is considerably higher than for dc voltage, which makes it possible to reduce the number of capacitors in the chain and the inductance of the ISD. Additional methods for reduction of the inductance of the VPG-ISD charging circuit are examined. Reduction of the charging time of the storage device makes the operation of the switch connecting the ISD to the shaping line more stable

  1. Intermediate Ethanol Blends Catalyst Durability Program

    Energy Technology Data Exchange (ETDEWEB)

    West, Brian H; Sluder, Scott; Knoll, Keith; Orban, John; Feng, Jingyu

    2012-02-01

    In the summer of 2007, the U.S. Department of Energy (DOE) initiated a test program to evaluate the potential impacts of intermediate ethanol blends (also known as mid-level blends) on legacy vehicles and other engines. The purpose of the test program was to develop information important to assessing the viability of using intermediate blends as a contributor to meeting national goals for the use of renewable fuels. Through a wide range of experimental activities, DOE is evaluating the effects of E15 and E20 - gasoline blended with 15% and 20% ethanol - on tailpipe and evaporative emissions, catalyst and engine durability, vehicle driveability, engine operability, and vehicle and engine materials. This report provides the results of the catalyst durability study, a substantial part of the overall test program. Results from additional projects will be reported separately. The principal purpose of the catalyst durability study was to investigate the effects of adding up to 20% ethanol to gasoline on the durability of catalysts and other aspects of the emissions control systems of vehicles. Section 1 provides further information about the purpose and context of the study. Section 2 describes the experimental approach for the test program, including vehicle selection, aging and emissions test cycle, fuel selection, and data handling and analysis. Section 3 summarizes the effects of the ethanol blends on emissions and fuel economy of the test vehicles. Section 4 summarizes notable unscheduled maintenance and testing issues experienced during the program. The appendixes provide additional detail about the statistical models used in the analysis, detailed statistical analyses, and detailed vehicle specifications.

  2. Connectomic intermediate phenotypes for psychiatric disorders

    Directory of Open Access Journals (Sweden)

    Alex eFornito

    2012-04-01

    Full Text Available Psychiatric disorders are phenotypically heterogeneous entities with a complex genetic basis. To mitigate this complexity, many investigators study so-called intermediate phenotypes that putatively provide a more direct index of the physiological effects of candidate genetic risk variants than overt psychiatric syndromes. Magnetic resonance imaging (MRI is a particularly popular technique for measuring such phenotypes because it allows interrogation of diverse aspects of brain structure and function in vivo. Much of this work however, has focused on relatively simple measures that quantify variations in the physiology or tissue integrity of specific brain regions in isolation, contradicting an emerging consensus that most major psychiatric disorders do not arise from isolated dysfunction in one or a few brain regions, but rather from disturbed interactions within and between distributed neural circuits; i.e., they are disorders of brain connectivity. The recent proliferation of new MRI techniques for comprehensively mapping the entire connectivity architecture of the brain, termed the human connectome, has provided a rich repertoire of tools for understanding how genetic variants implicated in mental disorder impact distinct neural circuits. In this article, we review research using these connectomic techniques to understand how genetic variation influences the connectivity and topology of human brain networks. We highlight recent evidence from twin and imaging genetics studies suggesting that the penetrance of candidate risk variants for mental illness, such as those in SLC6A4, MAOA, ZNF804A and APOE, may be higher for intermediate phenotypes characterised at the level of distributed neural systems than at the level of spatially localised brain regions. The findings indicate that imaging connectomics provides a powerful framework for understanding how genetic risk for psychiatric disease is expressed through altered structure and function of

  3. Performance of the SLC polarized electron source with high polarization

    International Nuclear Information System (INIS)

    Clendenin, J.E.; Alley, R.K.; Aoyagi, H.

    1993-04-01

    For the 1992 operating cycle of the SLAC Linear Collider (SLC), the polarized electron source (PES) during its maiden run successfully met the pulse intensity and overall efficiency requirements of the SLC. However, the polarization of the bulk GaAs cathode was low (∼27%) and the pulse-to-pulse stability was marginal. We have shown that adequate charge for the SLC can be extracted from a strained layer cathode having P e ∼80% even though the quantum efficiency (QE) is - beam stability. The performance of the PES during the 1993 SLC operating cycle with these and other improvements is discussed

  4. PIPER: Primordial Inflation Polarization Explorer

    Science.gov (United States)

    Lazear, Justin; Benford, D.; Chuss, D.; Fixsen, D.; Hinderks, J.; Hinshaw, G.; Jhabvala, C.; Johnson, B.; Kogut, A.; Mirel, P.; Mosely, H.; Staguhn, J.; Wollack, E.; Weston, A.; Vlahacos, K.; Bennett, C.; Eimer, J.; Halpern, M.; Irwin, K.; Dotson, J.; Ade, P.; Tucker, C.

    2011-05-01

    The Primordial Inflation Polarization Explorer (PIPER) is a balloon-borne instrument to measure the polarization of the cosmic microwave background in search of the expected signature of primordial gravity waves excited during an inflationary epoch shortly after the Big Bang. PIPER consists of two co-aligned telescopes, one sensitive to the Q Stokes parameter and the other to U. Sky signals will be detected with 5120 transition edge sensor (TES) bolometers distributed in four rectangular close-packed arrays maintained at 100 mK. To maximize the sensitivity of the instrument, both telescopes are mounted within a single open bucket dewar and are maintained at 1.5 K throughout flight, with no ambient-temperature windows between the sky and the detectors. To mitigate the effects of systematic errors, the polarized sky signals will be modulated using a variable-delay polarization modulator. PIPER will observe at frequencies 200, 270, 350, and 600 GHz to separate the CMB from polarized dust emission within the Galaxy. A series of flights alternating between northern and southern hemisphere launch sites will produce nearly full-sky maps in Stokes I, Q, U, and V. I will discuss the current status and potential science returns from the PIPER project.

  5. Polar metals by geometric design

    Science.gov (United States)

    Kim, T. H.; Puggioni, D.; Yuan, Y.; Xie, L.; Zhou, H.; Campbell, N.; Ryan, P. J.; Choi, Y.; Kim, J.-W.; Patzner, J. R.; Ryu, S.; Podkaminer, J. P.; Irwin, J.; Ma, Y.; Fennie, C. J.; Rzchowski, M. S.; Pan, X. Q.; Gopalan, V.; Rondinelli, J. M.; Eom, C. B.

    2016-05-01

    Gauss’s law dictates that the net electric field inside a conductor in electrostatic equilibrium is zero by effective charge screening; free carriers within a metal eliminate internal dipoles that may arise owing to asymmetric charge distributions. Quantum physics supports this view, demonstrating that delocalized electrons make a static macroscopic polarization, an ill-defined quantity in metals—it is exceedingly unusual to find a polar metal that exhibits long-range ordered dipoles owing to cooperative atomic displacements aligned from dipolar interactions as in insulating phases. Here we describe the quantum mechanical design and experimental realization of room-temperature polar metals in thin-film ANiO3 perovskite nickelates using a strategy based on atomic-scale control of inversion-preserving (centric) displacements. We predict with ab initio calculations that cooperative polar A cation displacements are geometrically stabilized with a non-equilibrium amplitude and tilt pattern of the corner-connected NiO6 octahedra—the structural signatures of perovskites—owing to geometric constraints imposed by the underlying substrate. Heteroepitaxial thin-films grown on LaAlO3 (111) substrates fulfil the design principles. We achieve both a conducting polar monoclinic oxide that is inaccessible in compositionally identical films grown on (001) substrates, and observe a hidden, previously unreported, non-equilibrium structure in thin-film geometries. We expect that the geometric stabilization approach will provide novel avenues for realizing new multifunctional materials with unusual coexisting properties.

  6. NMR dispersion measurement of dynamic nuclear polarization

    International Nuclear Information System (INIS)

    Davies, K.; Cox, S.F.J.

    1978-01-01

    The feasibility of monitoring dynamic nuclear polarization from the NMR dispersive susceptibility is examined. Two prototype instruments are tested in a polarized proton target using organic target material. The more promising employs a tunnel diode oscillator, inside the target cavity, and should provide a precise polarization measurement working at a frequency far enough from the main resonance for the disturbance of the measured polarization to be negligible. Other existing methods for measuring target polarization are briefly reviewed. (author)

  7. Polarization in electron and proton beams

    International Nuclear Information System (INIS)

    Buon, J.

    1986-03-01

    One first introduces the concept of polarization for spin 1/2 particle beams and discusses properties of spin kinetics in a stationary magnetic field. Then the acceleration of polarized protons in synchrotrons is studied with emphasis on depolarization when resonances are crossed and on the cures for reducing it. Finally, transverse polarization of electrons in storage rings is discussed as an equilibrium between polarizing and depolarizing effects of synchrotron radiation. Means for obtaining longitudinal polarization are also treated

  8. Frequency dependent polarization in blazars

    International Nuclear Information System (INIS)

    Bjoernsson, C.I.

    1984-10-01

    It is argued that the intrinsic frequency dependent polarization in blazars finds its most straightforward explanations in terms of a single rather than a multicomponent sourcemodel. In order to reproduce the observations, under the assumption that the emission mechanism is optically thin synchrotron radiation, both a well ordered magnetic field and an electron distribution with a sharp break or cuttoff are necessary. Non-uniform pitch angle distribution and/or environments where synchrotron losses are important are both conducive to producing strong frequency dependent polarization. Reasons are put forth as to why such conditions ar expected to occur in blazars. Two specific models are discussed in detail and it is shown that they are both able to produce strong frequency dependent polarization, even when the spectral index changes by a small amount only. (orig.)

  9. Report of the polarization group

    International Nuclear Information System (INIS)

    Ford, W.; Kondo, K.; Martin, F.; Manning, G.; Miller, D.; Prescott, C.

    1975-01-01

    The use of longitudinal polarization in the reaction e + e - → μ + μ - was studied. Modifications of the magnetic insertion which could reduce synchrotron radiation by two or more were considered. In addition, a specific design is suggested which incorporates the optimized magnetic configuration; it is assumed that no particle detection is necessary near the interaction vertex and the synchrotron radiation is ''dumped'' up - and downstream. Also considered were vacuum chambers in which the synchrotron radiation is absorbed locally so that shielded regions are provided for detectors near the interaction vertex. A scheme for rotating the polarization outside the experiment areas is detailed; in this way the design of experiments is greatly simplified. Local intense ionization of residual gas in the interaction region due to synchrotron radiation at the insertion was studied. Finally, some general considerations in the production and measurement of beam polarization are summarized. 2 figures

  10. Uses of laser optical pumping to produce polarized ion beams

    International Nuclear Information System (INIS)

    Anderson, L.W.

    1983-01-01

    Laser optical pumping can be used to produce polarized alkali atom beams or polarized alkali vapor targets. Polarized alkali atom beams can be converted into polarized alkali ion beams, and polarized alkali vapor targets can be used to produce polarized H - or 3 He - ion beams. In this paper the authors discuss how the polarized alkali atom beams and polarized alkali vapor targets are used to produce polarized ion beams with emphasis on the production of polarized negative ion beams

  11. Polarization-Dependent Multi-Functional Metamaterial as Polarization Filter, Transparent Wall and Circular Polarizer using Ring-Cross Resonator

    Directory of Open Access Journals (Sweden)

    Z. Zhang

    2017-09-01

    Full Text Available We propose a polarization-dependent multi-functional metamaterial using ring-cross resonator. Based on the analysis of surface current distributions induced by different polarized incidence, we demonstrate that the proposed metamaterial serves as a polarization filter, a transparent wall and a circular polarizer under different polarization normal incidence. Additionally, parameter analyses on the control of resonance are discussed to complementally explain the physical origin. Simulated results show that the proposed metamaterial functions as a polarization filter eliminating the x-polarization wave at 10.1 GHz and y-polarization wave at 14.3 GHz, a transparent wall transmitting both x-polarized and y-polarized incident waves at 12.6 GHz, and a broadband circular polarizer converting the +45° polarized (-45° polarized incident wave to the left (right handed circularly polarized wave from 10.8 to 12.8 GHz, respectively. Measured results agree well with the simulation and validate the performance of the proposed multifunctional metamaterial.

  12. Energy and polarization dependence of resonant inelastic X-ray scattering in Nd2CuO4

    International Nuclear Information System (INIS)

    Hill, J.P.; Kao, C.C.; Haemaelaeinen, K.

    1998-01-01

    The authors report the energy and polarization dependence of resonant inelastic x-ray scattering from Nd 2 CuO 4 . An energy loss feature at ∼6 eV is observed in the vicinity of the Cu K-edge. Numerical calculations based on the Anderson impurity model identify this as a charge transfer excitation to the anti-bonding state. The incident polarization is shown to select the intermediate states participating in the resonance process. Resonances are observed at 8,990 eV and 9,000 eV with the incident polarization perpendicular and parallel to the CuO planes, respectively. In contrast to the single-site model calculations, no resonances are observed associated with the 1s3d 10 L intermediate states, suggesting non-local effects play a role

  13. The roles and regulation of the actin cytoskeleton, intermediate filaments and microtubules in smooth muscle cell migration.

    Science.gov (United States)

    Tang, Dale D; Gerlach, Brennan D

    2017-04-08

    Smooth muscle cell migration has been implicated in the development of respiratory and cardiovascular systems; and airway/vascular remodeling. Cell migration is a polarized cellular process involving a protrusive cell front and a retracting trailing rear. There are three cytoskeletal systems in mammalian cells: the actin cytoskeleton, the intermediate filament network, and microtubules; all of which regulate all or part of the migrated process. The dynamic actin cytoskeleton spatially and temporally regulates protrusion, adhesions, contraction, and retraction from the cell front to the rear. c-Abl tyrosine kinase plays a critical role in regulating actin dynamics and migration of airway smooth muscle cells and nonmuscle cells. Recent studies suggest that intermediate filaments undergo reorganization during migration, which coordinates focal adhesion dynamics, cell contraction, and nucleus rigidity. In particular, vimentin intermediate filaments undergo phosphorylation and reorientation in smooth muscle cells, which may regulate cell contraction and focal adhesion assembly/disassembly. Motile cells are characterized by a front-rear polarization of the microtubule framework, which regulates all essential processes leading to cell migration through its role in cell mechanics, intracellular trafficking, and signaling. This review recapitulates our current knowledge how the three cytoskeletal systems spatially and temporally modulate the migratory properties of cells. We also summarize the potential role of migration-associated biomolecules in lung and vascular diseases.

  14. Polarized electroluminescence from silicon nanostructures

    Energy Technology Data Exchange (ETDEWEB)

    Bagraev, Nikolay; Danilovsky, Eduard; Gets, Dmitry; Klyachkin, Leonid; Kudryavtsev, Andrey; Kuzmin, Roman; Malyarenko, Anna [Ioffe Physical-Technical Institute, 194021 St. Petersburg (Russian Federation); Mashkov, Vladimir [St. Petersburg State Polytechnical University, 195251 St. Petersburg (Russian Federation)

    2012-05-15

    We present the first findings of the circularly polarized electroluminescence (CPEL) from silicon nanostructures which are the p-type ultra-narrow silicon quantum well (Si-QW) confined by {delta}-barriers heavily doped with boron. The CPEL dependences on the forward current and lateral electric field show the circularly polarized light emission which appears to be caused by the exciton recombination through the negative-U dipole boron centers at the Si-QW-{delta}-barriers interface with the assistance of phosphorus donors. (copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  15. All-fiber polarization switch

    Science.gov (United States)

    Knape, Harald; Margulis, Walter

    2007-03-01

    We report an all-fiber polarization switch made out of silica-based microstructured fiber suitable for Q-switching all-fiber lasers. Nanosecond high-voltage pulses are used to heat and expand an internal electrode to cause λ/2-polarization rotation in less than 10 ns for 1.5 μm light. The 10 cm long component has an experimentally measured optical insertion loss of 0.2 dB and a 0-10 kHz repetition frequency capacity and has been durability tested for more than 109 pulses.

  16. The sensitivity of income polarization

    DEFF Research Database (Denmark)

    Hussain, Azhar

    2009-01-01

    This study looks at polarization and its components' sensitivity to assumptions about equivalence scales, income definition, ethical income distribution parameters, and the income accounting period. A representative sample of Danish individual incomes from 1984 to 2002 is utilised. Results show...... that polarization has increased over time, regardless of the applied measure, when the last part of the period is compared to the first part of the period; primary causes being increased inequality (alienation) and faster income growth among high incomes relative to those in the middle of the distribution...

  17. Graphics of polar figure; Graficado de figura polar

    Energy Technology Data Exchange (ETDEWEB)

    Macias B, L.R

    1991-11-15

    The objective of this work, is that starting from a data file coming from a spectra that has been softened, and of the one that have been generated its coordinates to project it in stereographic form, to create the corresponding polar figure making use of the Cyber computer of the ININ by means of the GRAPHOS package. This work only requires a Beta, Fi and Intensity (I) enter data file. It starts of the existence of a softened spectra of which have been generated already with these data, making use of some language that in this case was FORTRAN for the Cyber computer, a program is generated supported in the Graphos package that allows starting of a reading of the Beta, Fi, I file, to generate the points in a stereographic projection and that it culminates with the graph of the corresponding polar figure. The program will request the pertinent information that is wanted to capture in the polar figure just as: date, name of the enter file, indexes of the polar figure, number of levels, radio of the stereographic projection (cms.), crystalline system to which belongs the sample, name the neuter graph file by create and to add the own general data. (Author)

  18. Fetal intermediate lobe is stimulated by parturition.

    Science.gov (United States)

    Facchinetti, F; Lanzani, A; Genazzani, A R

    1989-11-01

    The fetal pituitary gland secretes beta-endorphin in blood in response to delivery. However, other forms of endorphin have recently been observed in the fetal pituitary, such as N-acetyl-beta-endorphin, which is devoid of opiate activity, and a desacetylated form of alpha-melanocyte-stimulating hormone. Both endorphins originate in the pituitary intermediate lobe. The sensitivity of this lobe to labor stress was assessed by the evaluation of beta-endorphin, N-acetyl-beta-endorphin, melanocyte-stimulating hormone, and desacetylated alpha-melanocyte-stimulating hormone in maternal plasma and cord blood in 11 cases of vaginal delivery and 10 cases of elective cesarean section without labor. Plasma peptide levels were determined by specific radioimmunoassays after extraction on Sep-Pak C-18 cartridges and high-performance liquid chromatography fractionation. Cord blood samples of infants delivered vaginally showed higher beta-endorphin (8.5 +/- 1.6 pmol/L, mean +/- SE) and desacetylated alpha-melanocyte-stimulating hormone (13.6 +/- 3.2 pmol/L) levels than those delivered by elective cesarean section (3.7 +/- 0.8 and 4.2 +/- 1.1 pmol/L, for beta-endorphin and desacetylated alpha-melanocyte-stimulating hormone, respectively). N-acetyl-beta-endorphin and alpha-melanocyte-stimulating hormone levels do not differ in relation to the mode of delivery. In maternal circulation beta-endorphin levels were higher in those delivered vaginally (5.2 pm 1) than in women who had cesarean sections (2.5 +/- 0.5 pmol/L), whereas no changes were found for the other peptides. In vaginal deliveries, the level of desacetylated alpha-melanocyte-stimulating hormone was higher in cord blood (13.6 +/- 3.2 pmol/L) than in maternal plasma (6.5 +/- 3 pmol/L); there were no significant differences with regard to the other peptides. Fetal and maternal levels of all the peptides were similar in cases of cesarean section. We conclude that parturition activates proopiomelanocortin peptide release from

  19. VIIRS/J1 polarization narrative

    Science.gov (United States)

    Waluschka, Eugene; McCorkel, Joel; McIntire, Jeff; Moyer, David; McAndrew, Brendan; Brown, Steven W.; Lykke, Keith R.; Young, James B.; Fest, Eric; Butler, James; Wang, Tung R.; Monroy, Eslim O.; Turpie, Kevin; Meister, Gerhard; Thome, Kurtis J.

    2015-09-01

    The polarization sensitivity of the Visible/NearIR (VISNIR) bands in the Joint Polar Satellite Sensor 1 (J1) Visible Infrared Imaging Radiometer Suite (VIIRS) instrument was measured using a broadband source. While polarization sensitivity for bands M5-M7, I1, and I2 was less than 2.5 %, the maximum polarization sensitivity for bands M1, M2, M3, and M4 was measured to be 6.4 %, 4.4 %, 3.1 %, and 4.3 %, respectively with a polarization characterization uncertainty of less than 0.38%. A detailed polarization model indicated that the large polarization sensitivity observed in the M1 to M4 bands is mainly due to the large polarization sensitivity introduced at the leading and trailing edges of the newly manufactured VISNIR bandpass focal plane filters installed in front of the VISNIR detectors. This was confirmed by polarization measurements of bands M1 and M4 bands using monochromatic light. Discussed are the activities leading up to and including the two polarization tests, some discussion of the polarization model and the model results, the role of the focal plane filters, the polarization testing of the Aft-Optics-Assembly, the testing of the polarizers at the National Aeronautics and Space Administration's (NASA) Goddard center and at the National Institute of Science and Technology (NIST) facility and the use of NIST's Traveling Spectral Irradiance and Radiance responsivity Calibrations using Uniform Sources (T-SIRCUS) for polarization testing and associated analyses and results.

  20. VIIRS-J1 Polarization Narrative

    Science.gov (United States)

    Waluschka, Eugene; McCorkel, Joel; McIntire, Jeff; Moyer, David; McAndrew, Brendan; Brown, Steven W.; Lykke, Keith; Butler, James; Meister, Gerhard; Thome, Kurtis J.

    2015-01-01

    The VIS/NIR bands polarization sensitivity of Joint Polar Satellite Sensor 1 (JPSS1) Visible/Infrared Imaging Radiometer Suite (VIIRS) instrument was measured using a broadband source. While polarization sensitivity for bands M5-M7, I1, and I2 was less than 2.5%, the maximum polarization sensitivity for bands M1, M2, M3, and M4 was measured to be 6.4%, 4.4%, 3.1%, and 4.3%, respectively with a polarization characterization uncertainty of less than 0.3%. A detailed polarization model indicated that the large polarization sensitivity observed in the M1 to M4 bands was mainly due to the large polarization sensitivity introduced at the leading and trailing edges of the newly manufactured VISNIR bandpass focal plane filters installed in front of the VISNIR detectors. This was confirmed by polarization measurements of bands M1 and M4 bands using monochromatic light. Discussed are the activities leading up to and including the instruments two polarization tests, some discussion of the polarization model and the model results, the role of the focal plane filters, the polarization testing of the Aft-Optics-Assembly, the testing of the polarizers at Goddard and NIST and the use of NIST's T-SIRCUS for polarization testing and associated analyses and results.

  1. Experimental studies of nucleon-nucleon and pion-nucleus interactions at intermediate energies

    Energy Technology Data Exchange (ETDEWEB)

    1990-10-01

    This report summarizes the work on experimental research in intermediate energy nuclear and particle physics carried out by New Mexico State University in 1988--91. Most of these studies have involved investigations of neutron-proton and pion-nucleus interactions. The neutron-proton research is part of a program of studies of interactions between polarized nucleons that we have been involved with for more than ten years. Its purpose has been to help complete the determination of the full set of ten complex nucleon-nucleon amplitudes at energies up to 800 MeV, as well as to continue investigating the possibility of the existence of dibaryon resonances. The give complex isospin-one amplitudes have been fairly well determined, partly as a result of this work. Our work in this period has involved measurements and analysis of data on elastic scattering and total cross sections for polarized neutrons on polarized protons. The pion-nucleus research continues our studies of this interaction in regions where it has not been well explored. One set of experiments includes studies of pion elastic and double-charge-exchange scattering at energies between 300 and 550 MeV, where our data is unique. Another involves elastic and single-charge-exchange scattering of pions from polarized nuclear targets, a new field of research which will give the first extensive set of information on spin-dependent pion-nucleus amplitudes. Still another involves the first set of detailed studies of the kinematic correlations among particles emitted following pion absorption in nuclei.

  2. Experimental studies of nucleon-nucleon and pion-nucleus interactions at intermediate energies

    International Nuclear Information System (INIS)

    1990-01-01

    This report summarizes the work on experimental research in intermediate energy nuclear and particle physics carried out by New Mexico State University in 1988--91. Most of these studies have involved investigations of neutron-proton and pion-nucleus interactions. The neutron-proton research is part of a program of studies of interactions between polarized nucleons that we have been involved with for more than ten years. Its purpose has been to help complete the determination of the full set of ten complex nucleon-nucleon amplitudes at energies up to 800 MeV, as well as to continue investigating the possibility of the existence of dibaryon resonances. The give complex isospin-one amplitudes have been fairly well determined, partly as a result of this work. Our work in this period has involved measurements and analysis of data on elastic scattering and total cross sections for polarized neutrons on polarized protons. The pion-nucleus research continues our studies of this interaction in regions where it has not been well explored. One set of experiments includes studies of pion elastic and double-charge-exchange scattering at energies between 300 and 550 MeV, where our data is unique. Another involves elastic and single-charge-exchange scattering of pions from polarized nuclear targets, a new field of research which will give the first extensive set of information on spin-dependent pion-nucleus amplitudes. Still another involves the first set of detailed studies of the kinematic correlations among particles emitted following pion absorption in nuclei

  3. MEASUREMENT OF POLARIZATION OBSERVABLES IN VECTOR MESON PHOTOPRODUCTION USING A TRANSVERSELY-POLARIZED FROZEN-SPIN TARGET AND POLARIZED PHOTONS AT CLAS, JEFFERSON LAB

    Energy Technology Data Exchange (ETDEWEB)

    Roy, Priyashree [Florida State Univ., Tallahassee, FL (United States); Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

    2016-11-30

    The study of baryon resonances provides a deeper understanding of the strong interaction because the dynamics and relevant degrees of freedom hidden within them are re ected by the properties of the excited states of baryons. Higher-lying excited states at and above 1.7 GeV/c2 are generally predicted to have strong couplings to final states involving a heavier meson, e. g. one of the vector mesons, ρ, ω φ, as compared to a lighter pseudoscalar meson, e. g. π and η. Decays to the ππΝ final states via πΔ also become more important through the population of intermediate resonances. We observe that nature invests in mass rather than momentum. The excited states of the nucleon are usually found as broadly overlapping resonances which may decay into a multitude of final states involving mesons and baryons. Polarization observables make it possible to isolate single resonance contributions from other interference terms. The CLAS g9 (FROST) experiment, as part of the N* spectroscopy program at Je?erson Laboratory, accumulated photoproduction data using circularly- & linearly-polarized photons incident on a transversely-polarized butanol target (g9b experiment) in the photon energy range 0:3-2:4 GeV & 0:7-2:1 GeV, respectively. In this work, the analysis of reactions and polarization observables which involve two charged pions, either in the fully exclusive reaction γρ -> ρπ+π- or in the semi-exclusive reaction with a missing neutral pion, γρ -> ρπ+π-(π0) will be presented. For the reaction ρπ+π-, eight polarization observables (Is, Ic, Px, Py, Psx; y, Pcx; y) have been extracted. The high statistics data rendered it possible to extract these observables in three dimensions. All of them are first-time measurements. The fairly good agreement of Is, Ic obtained from this analysis with the experimental results from a previous CLAS experiment provides support for the first-time measurements. For the reaction γρ -> ρω -> ρπ+π(π0, five polarization

  4. Taxation of Financial Intermediation Activities in Hong Kong

    OpenAIRE

    Jack M. Mintz; Stephen R. Richardson

    2001-01-01

    This paper discusses issues related to the taxation of financial intermediation in Hong Kong in the context of Hong Kong's position as a major regional financial centre. It first provides some background analysis as to the definition of financial intermediation and identification of the providers of financial services. This is then followed by a discussion of the principles of taxation applicable to financial intermediation, including a comparison of income taxes to consumption taxes. Some sp...

  5. Intermediate mass fragments emission in binary fragmentation model

    International Nuclear Information System (INIS)

    Bhattacharya, C.; Bhattacharya, S.

    1991-01-01

    Intermediate mass fragments emission in intermediate-energy nucleus-nucleus collisions has been studied in the framework of a generalized model where the fragments are assumed to be emitted from binary fissionlike decay of the fully equilibrated compound nucleus. The present formulation, with a schematic exit channel shape configuration and simple rotating liquid-drop nuclear potential, has been found to explain most of the intermediate mass fragments emission cross sections reasonably well without incorporating any free parameters in the calculation

  6. Measurement of inclusive quasielastic scattering of polarized electrons from polarized 3He

    International Nuclear Information System (INIS)

    Woodward, C.E.; Beise, E.J.; Belz, J.E.; Carr, R.W.; Filippone, B.W.; Lorenzon, W.B.; McKeown, R.D.; Mueller, B.; O'Neill, T.G.; Dodson, G.; Dow, K.; Farkhondeh, M.; Kowalski, S.; Lee, K.; Makins, N.; Milner, R.; Thompson, A.; Tieger, D.; van den Brand, J.; Young, A.; Yu, X.; Zumbro, J.

    1990-01-01

    We report a measurement of the asymmetry in spin-dependent quasielastic scattering of longitudinally polarized electrons from a polarized 3 He gas target. This measurement represents the first demonstration of a new method for studying electromagnetic nuclear structure: the scattering of polarized electrons from a polarized nuclear target. The measured asymmetry is in good agreement with a Faddeev calculation and supports the picture of spin-dependent quasielastic scattering from polarized 3 He as predominantly scattering from a polarized neutron

  7. La escritura intermedial en la escena actual

    Directory of Open Access Journals (Sweden)

    Luis Thenon

    2013-08-01

    Full Text Available Las escrituras artísticas actuales integran, en el marco determinado por las realidades intermediales de la escena tecnológica, el concepto de diseño como manipulación perceptiva del espacio, lo que constituye uno de los instrumentos determinantes en la puesta en marcha de un cuadro compositivo de resonancias transformacionales. Podríamos en este sentido hablar de una nueva ecología artística y en especial, teatral. En la renovación del pensamiento teatral actualizado, fuertemente influenciado por la estructura discursiva cinematográfica y por los universos sensoriales de la cultura tecnológica de la imagen y del sonido, está la base de la multiplicación diegética, de la superposición, de la fragmentación de los discursos y de la praxis inter-relacional en la que radica, en gran medida, la potencia intermedial de la escena actual.

  8. Electron scattering from sodium at intermediate energies

    International Nuclear Information System (INIS)

    Mitroy, J.; McCarthy, I.E.

    1986-10-01

    A comprehensive comparison is made between theoretical calculations and experimental data for intermediate energy (≥ 10 eV) electron scattering from sodium vapour. The theoretical predictions of coupled-channels calculations (including one, two or four channels) do not agree with experimental values of the differential cross sections for elastic scattering or the resonant 3s to 3p excitation. Increasingly-more-sophisticated calculations, incorporating electron correlations in the target states, and also including core-excited states in the close-coupling expansion, are done at a few selected energies in an attempt to isolate the cause of the discrepancies between theory and experiment. It is found that these more-sophisticated calculations give essentially the same results as the two- and four-channel calculations using Hartree-Fock wavefunctions. Comparison of the sodium high-energy elastic differential cross sections with those of neon suggests that the sodium differential cross section experiments may suffer from systematic errors. There is also disagreement, at the higher energies, between theoretical values for the scattering parameters and those that are derived from laser-excited superelastic scattering and electron photon coincidence experiments. When allowance is made for the finite acceptance angle of the electron spectrometers used in the experiments by convoluting the theory with a function representing the distribution of electrons entering the electron spectrometer it is found that the magnitudes of the differences between theory and experiment are reduced

  9. On the Intermediate Line Region in AGNs

    Energy Technology Data Exchange (ETDEWEB)

    Adhikari, Tek P.; Różańska, Agata; Hryniewicz, Krzysztof [Nicolaus Copernicus Astronomical Center, Polish Academy of Sciences, Warsaw (Poland); Czerny, Bozena [Nicolaus Copernicus Astronomical Center, Polish Academy of Sciences, Warsaw (Poland); Center for Theoretical Physics, Polish Academy of Sciences, Warsaw (Poland); Ferland, Gary J., E-mail: tek@camk.edu.pl [Department of Physics and Astronomy, The University of Kentucky, Lexington, KY (United States)

    2017-09-29

    In this paper we explore the intermediate line region (ILR) by using the photoionisation simulations of the gas clouds present at different radial distances from the center, corresponding to the locations from BLR out to NLR in four types of AGNs. We let for the presence of dust whenever conditions allow for dust existence. All spectral shapes are taken from the recent multi-wavelength campaigns. The cloud density decreases with distance as a power law. We found that the slope of the power law density profile does not affect the line emissivity radial profiles of major emission lines: Hβ, He II, Mg II, C III, and O III. When the density of the cloud at the sublimation radius is as high as 10{sup 11.5} cm{sup −3}, the ILR should clearly be seen in the observations independently of the shape of the illuminating radiation. Moreover, our result is valid for low ionization nuclear emission regions of active galaxies.

  10. Substrate radical intermediates in soluble methane monooxygenase

    International Nuclear Information System (INIS)

    Liu Aimin; Jin Yi; Zhang Jingyan; Brazeau, Brian J.; Lipscomb, John D.

    2005-01-01

    EPR spin-trapping experiments were carried out using the three-component soluble methane monooxygenase (MMO). Spin-traps 5,5-dimethyl-1-pyrroline N-oxide (DMPO), α-4-pyridyl-1-oxide N-tert-butylnitrone (POBN), and nitrosobenzene (NOB) were used to investigate the possible formation of substrate radical intermediates during catalysis. In contrast to a previous report, the NADH-coupled oxidations of various substrates did not produce any trapped radical species when DMPO or POBN was present. However, radicals were detected by these traps when only the MMO reductase component and NADH were present. DMPO and POBN were found to be weak inhibitors of the MMO reaction. In contrast, NOB is a strong inhibitor for the MMO-catalyzed nitrobenzene oxidation reaction. When NOB was used as a spin-trap in the complete MMO system with or without substrate, EPR signals from an NOB radical were detected. We propose that a molecule of NOB acts simultaneously as a substrate and a spin-trap for MMO, yielding the long-lived radical and supporting a stepwise mechanism for MMO

  11. Uranium concentration monitor manual, secondary intermediate evaporator

    International Nuclear Information System (INIS)

    Russo, P.A.; Sprinkle, J.K. Jr.; Slice, R.W.; Strittmatter, R.B.

    1985-08-01

    This manual describes the design, operation, and measurement control procedures for the automated uranium concentration monitor on the secondary intermediate evaporator at the Oak Ridge Y-12 Plant. The nonintrusive monitor provides a near-real time readout of uranium concentration in the return loop of time recirculating evaporator for purposes of process monitoring and control. A detector installed near the bottom of the return loop is used to acquire spectra of gamma rays from the evaporator solutions during operation. Pulse height analysis of each spectrum gives the information required to deduce the concentration of uranium in the evaporator solution in near-real time. The visual readout of concentration is updated at the end of every assay cycle. The readout includes an alphanumeric display of uranium concentration and an illuminated, colored LED (in an array of colored LEDs) indicating whether the measured concentration is within (or above or below) the desired range. An alphanumeric display of evaporator solution acid molarity is also available to the operator. 9 refs., 16 figs., 4 tabs

  12. Intermediate Temperature Fluids Life Tests — Theory

    Science.gov (United States)

    Tarau, Calin; Sarraf, David B.; Locci, Ivan E.; Anderson, William G.

    2007-01-01

    There are a number of different applications that could use heat pipes or loop heat pipes (LHPs) in the intermediate temperature range of 450 to 750 K, including space nuclear power system radiators, and high temperature electronics cooling. Potential working fluids include organic fluids, elements, and halides, with halides being the least understood, with only a few life tests conducted. Potential envelope materials for halide working fluids include pure aluminum, aluminum alloys, commercially pure (CP) titanium, titanium alloys, and corrosion resistant superalloys. Life tests were conducted with three halides (AlBr3, SbBr3, and TiCl4) and water in three different envelopes: two aluminum alloys (Al-5052, Al-6061) and CP-2 titanium. The AlBr3 attacked the grain boundaries in the aluminum envelopes, and formed TiAl compounds in the titanium. The SbBr3 was incompatible with the only envelope material that it was tested with, Al-6061. TiCl4 and water were both compatible with CP2-titanium. A theoretical model was developed that uses electromotive force differences to predict the compatibility of halide working fluids with envelope materials. This theory predicts that iron, nickel, and molybdenum are good envelope materials, while aluminum and titanium halides are good working fluids. The model is in good agreement with results from previous life tests, as well as the current life tests.

  13. Intermediate Temperature Fluids Life Tests - Theory

    Science.gov (United States)

    Tarau, Calin; Sarraf, David B.; Locci, Ivan E.; Anderson, William G.

    2008-01-01

    There are a number of different applications that could use heat pipes or loop heat pipes (LHPs) in the intermediate temperature range of 450 to 750 K, including space nuclear power system radiators, and high temperature electronics cooling. Potential working fluids include organic fluids, elements, and halides, with halides being the least understood, with only a few life tests conducted. Potential envelope materials for halide working fluids include pure aluminum, aluminum alloys, commercially pure (CP) titanium, titanium alloys, and corrosion resistant superalloys. Life tests were conducted with three halides (AlBr3, SbBr3, and TiCl4) and water in three different envelopes: two aluminum alloys (Al-5052, Al-6061) and Cp-2 titanium. The AlBr3 attacked the grain boundaries in the aluminum envelopes, and formed TiAl compounds in the titanium. The SbBr3 was incompatible with the only envelope material that it was tested with, Al-6061. TiCl4 and water were both compatible with CP2-titanium. A theoretical model was developed that uses electromotive force differences to predict the compatibility of halide working fluids with envelope materials. This theory predicts that iron, nickel, and molybdenum are good envelope materials, while aluminum and titanium halides are good working fluids. The model is in good agreement with results form previous life tests, as well as the current life tests.

  14. Hyperon polarization: theory and experiments

    Energy Technology Data Exchange (ETDEWEB)

    Magnin, J.; Simao, F.R.A.

    1996-01-01

    We give a brief review of the experimental situation concerning hyperon polarization. We mention also the current models developed to understand the experimental results and make some comments on some theoretical aspects contained in the Thomas precession model. (author). 8 ref.

  15. Tau physics with polarized beams

    Energy Technology Data Exchange (ETDEWEB)

    Daoudi, M.

    1995-11-01

    We present the first results on tau physics using polarized beams. These include measurements of the {tau} Michel parameters {xi} and {xi}{delta} and the {tau} neutrino helicity h{sub {nu}}. The measurements were performed using the SLD detector at the Stanford Linear Collider (SLC).

  16. Circular polarization observed in bioluminescence

    NARCIS (Netherlands)

    Wijnberg, Hans; Meijer, E.W.; Hummelen, J.C.; Dekkers, H.P.J.M.; Schippers, P.H.; Carlson, A.D.

    1980-01-01

    While investigating circular polarization in luminescence, and having found it in chemiluminescence, we have studied bioluminescence because it is such a widespread and dramatic natural phenomenon. We report here that left and right lanterns of live larvae of the fireflies, Photuris lucicrescens and

  17. Verum focus and polar questions

    Directory of Open Access Journals (Sweden)

    Ion Giurgea

    2012-11-01

    Full Text Available We argue that some word order phenomena in Romanian and Sardinian are the result of a checking operation in the left periphery involving verum focus (i.e. focus on the polarity component of the sentence. In particular, this operation accounts for some word order patterns found in polar questions. In Romanian, polarity fronting is realized as head-movement of (V+T to a higher peripheral head which bears a Focus-probe. This licenses VS orders for predications in which VS is not allowed as a neutral order (i-level predicates, iteratives, generics. In Sardinian, an entire phrase headed by the lexical predicate (verbal non-finite form or non-verbal predicate is fronted before the auxiliary. We argue that this order is obtained by two movement operations, head-raising of Aux to Foc and movement of the predicate phrase to SpecFoc. We also present the semantics of polarity focus, distinguishing several types of focus (informational, emphatic, contrastive.

  18. Free radicals and polarized targets

    Science.gov (United States)

    Bunyatova, E. I.

    2004-06-01

    Many free radicals were added to organic compounds in search of high proton and deuteron polarizations. Few found practical application. A short review is presented, and special attention is given to some stable nitroxyl radicals which have lately been admixed to organic compounds solid at room temperature, in particular to scintillators.

  19. Free radicals and polarized targets

    Energy Technology Data Exchange (ETDEWEB)

    Bunyatova, E.I. E-mail: bunyatel@nusun.jinr.ru

    2004-06-21

    Many free radicals were added to organic compounds in search of high proton and deuteron polarizations. Few found practical application. A short review is presented, and special attention is given to some stable nitroxyl radicals which have lately been admixed to organic compounds solid at room temperature, in particular to scintillators.

  20. History of the polarized beam

    Energy Technology Data Exchange (ETDEWEB)

    Parker, E F

    1979-01-01

    In 1973, the first high energy polarized proton beam was developed at the Argonne Zero Gradient Synchrotron (ZGS). It operated very successfully and productively until 1979 when the ZGS was shut down permanently. This report describes the development, characteristics, and operations of this facility.

  1. TREC Dynamic Domain: Polar Science

    Science.gov (United States)

    2015-11-20

    similarity. However, not all teams that submitted web crawls to this dataset applied their jaccard- similarity algorithms . 4.2 Data Format ...analysis. These algorithms were focused then on allowing better answers to the below representative science queries of our Polar data: 1. What...

  2. Bacteriophage in polar inland waters

    Science.gov (United States)

    Säwström, Christin; Lisle, John; Anesio, A.M.; Priscu, John C.; Laybourn-Parry, J.

    2008-01-01

    Bacteriophages are found wherever microbial life is present and play a significant role in aquatic ecosystems. They mediate microbial abundance, production, respiration, diversity, genetic transfer, nutrient cycling and particle size distribution. Most studies of bacteriophage ecology have been undertaken at temperate latitudes. Data on bacteriophages in polar inland waters are scant but the indications are that they play an active and dynamic role in these microbially dominated polar ecosystems. This review summarises what is presently known about polar inland bacteriophages, ranging from subglacial Antarctic lakes to glacial ecosystems in the Arctic. The review examines interactions between bacteriophages and their hosts and the abiotic and biotic variables that influence these interactions in polar inland waters. In addition, we consider the proportion of the bacteria in Arctic and Antarctic lake and glacial waters that are lysogenic and visibly infected with viruses. We assess the relevance of bacteriophages in the microbial loop in the extreme environments of Antarctic and Arctic inland waters with an emphasis on carbon cycling.

  3. High current polarized proton sources

    Energy Technology Data Exchange (ETDEWEB)

    Alessi, J.G.

    1988-01-01

    Polarized proton sources are now being used more frequently on linacs. In pulsed operation up to 10 mA of /rvec H//sup +/ and 0.4 mA of /rvec H//sup /minus// have been produced. The present status of these sources, and developments to reach even higher intensities, are reviewed. 39 refs., 1 tab.

  4. the effect of surface polarity

    Indian Academy of Sciences (India)

    Abstract. An implant material when comes in contact with blood fluids (e.g., blood and lymph), adsorb proteins spontaneously on its surface. Notably, blood coagulation is influenced by many factors, including mainly chemical structure and polarity (charge) of the material. The present study describes the methodology to ...

  5. Verum focus and polar questions

    Directory of Open Access Journals (Sweden)

    Ion Giurgea

    2012-01-01

    Full Text Available We argue that some word order phenomena in Romanian and Sardinian are the result of a checkingoperation in the left periphery involving verum focus (i.e. focus on the polarity component of the sentence.In particular, this operation accounts for some word order patterns found in polar questions. In Romanian,polarity fronting is realized as head-movement of (V+T to a higher peripheral head which bears a Focusprobe.This licenses VS orders for predications in which VS is not allowed as a neutral order (i-levelpredicates, iteratives, generics. In Sardinian, an entire phrase headed by the lexical predicate (verbal nonfiniteform or non-verbal predicate is fronted before the auxiliary. We argue that this order is obtained bytwo movement operations, head-raising of Aux to Foc and movement of the predicate phrase to SpecFoc. Wealso present the semantics of polarity focus, distinguishing several types of focus (informational, emphatic,contrastive.

  6. The SLC polarized electron source

    International Nuclear Information System (INIS)

    Clendenin, J.E.

    1990-10-01

    A polarized electron source consisting of a 3-electrode photocathode gun and a flashlamp-pumped dye laser has been designed and built for the SLC and is currently undergoing commissioning. The source is described, and the operating configuration is discussed. The present status of the source and future plans are briefly indicated. 7 refs., 4 figs

  7. Polar heating in Saturn's thermosphere

    Directory of Open Access Journals (Sweden)

    C. G. A. Smith

    2005-10-01

    Full Text Available A 3-D numerical global circulation model of the Kronian thermosphere has been used to investigate the influence of polar heating. The distributions of temperature and winds resulting from a general heat source in the polar regions are described. We show that both the total energy input and its vertical distribution are important to the resulting thermal structure. We find that the form of the topside heating profile is particularly important in determining exospheric temperatures. We compare our results to exospheric temperatures from Voyager occultation measurements (Smith et al., 1983; Festou and Atreya, 1982 and auroral H3+ temperatures from ground-based spectroscopic observations (e.g. Miller et al., 2000. We find that a polar heat source is consistent with both the Smith et al. determination of T∞~400 K at ~30° N and auroral temperatures. The required heat source is also consistent with recent estimates of the Joule heating rate at Saturn (Cowley et al., 2004. However, our results show that a polar heat source can probably not explain the Festou and Atreya determination of T∞~800 K at ~4° N and the auroral temperatures simultaneously. Keywords. Ionosphere (Planetary ionosphere – Magnetospherica physics (Planetary magnetospheres – Meterology and atmospheric dynamics (Thermospheric dynamics

  8. The Role of Solvent Polarity on Low-Temperature Methanol Synthesis Catalyzed by Cu Nanoparticles

    International Nuclear Information System (INIS)

    Ahoba-Sam, Christian; Olsbye, Unni; Jens, Klaus-Joachim

    2017-01-01

    Methanol syntheses at low temperature in a liquid medium present an opportunity for full syngas conversion per pass. The aim of this work was to study the role of solvents polarity on low-temperature methanol synthesis reaction using eight different aprotic polar solvents. A “once through” catalytic system, which is composed of Cu nanoparticles and sodium methoxide, was used for methanol synthesis at 100°C and 20 bar syngas pressure. Solvent polarity rather than the 7–10 nm Cu (and 30 nm Cu on SiO 2 ) catalyst used dictated trend of syngas conversion. Diglyme with a dielectric constant (ε) = 7.2 gave the highest syngas conversion among the eight different solvents used. Methanol formation decreased with either increasing or decreasing solvent ε value of diglyme (ε = 7.2). To probe the observed trend, possible side reactions of methyl formate (MF), the main intermediate in the process, were studied. MF was observed to undergo two main reactions; (i) decarbonylation to form CO and MeOH and (ii) a nucleophilic substitution to form dimethyl ether and sodium formate. Decreasing polarity favored the decarbonylation side reaction while increasing polarity favored the nucleophilic substitution reaction. In conclusion, our results show that moderate polarity solvents, e.g., diglyme, favor MF hydrogenolysis and, hence, methanol formation, by retarding the other two possible side reactions.

  9. Induction of transverse polarity by blue light: an all-or-none response.

    Science.gov (United States)

    Nick, P; Schafer, E

    1991-10-01

    Phototropic stimulation induces a spatial memory. This was inferred from experiments with maize (Zea mays L.) coleoptiles involving opposing blue-light pulses, separated by variable time intervals, and rotation on a horizontal clinostat (Nick and Schafer, 1988b, Planta 175, 380-388). In those experiments, individual seedlings either curved towards the first or towards the second pulse, or they remained straight. Bending, if it occurred, seemed to be an all-or-none response. Intermediates, i.e. plants, bending only weakly, were not observed. In the first part of the present study it was attempted to create such intermediates. For this purpose the strength of the first, inducing, and the second, opposing, pulse was varied. The result was complex: (i) Individual seedlings maintained the all-or-none expression of spatial memory. (ii) However, on the level of the whole population, the time intervals at which a given response type dominated depended on the fluence ratio. (iii) Furthermore, the final curvature was determined by the fluence ratio. These results are discussed in terms of a blue-light-induced transverse polarity. This polarity initiates from a labile precursor, which can be reoriented by an opposing stimulation (indicated by the strong bending towards the second pulse). The strong curvatures towards the first pulse over long time intervals reveal that, eventually, the blue-light-induced transverse polarity becomes stabilised and thus immune to the counterpulse. In the second part of the study, the relation between phototropic transduction and transverse polarity was characterised by a phenomenological approach involving the following points: (i) Sensory adaptation for induction of transverse polarity disappears with a time course similar to that for phototropic sensory adaptatation. (ii) The fluence response for induction of transverse polarity is a saturation curve and not bell-shaped like the curve for phototropism (iii) For strong counterpulses and long

  10. The association of the HLA-A*24:02, B*39:01 and B*39:06 alleles with type 1 diabetes is restricted to specific HLA-DR/DQ haplotypes in Finns.

    Science.gov (United States)

    Mikk, M-L; Heikkinen, T; El-Amir, M I; Kiviniemi, M; Laine, A-P; Härkönen, T; Veijola, R; Toppari, J; Knip, M; Ilonen, J

    2017-04-01

    We analysed the previously reported association of the HLA-A*24:02, B*18 and B*39 alleles with type 1 diabetes and diabetes associated autoimmunity in the Finnish population applying HLA-DR/DQ stratification. Haplotype transmission was analysed in 2424 nuclear families from the Finnish Paediatric Diabetes Register. Survival analysis was applied to study the development of islet autoantibodies and further progression to clinical diabetes in the prospective follow-up cohort from the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) Study. The subjects were genotyped for specific HLA class I alleles by sequence-specific hybridization using lanthanide labelled nucleotide probes. The HLA-B*39:06 allele was found almost exclusively on the (DR8)-DQB1*04 haplotype in which its presence changed the disease risk status of the whole haplotype from neutral to predisposing. The HLA-A*24:02 and the B*39:01 alleles increased the diabetes-associated risk of the DRB1*04:04-DQA1*03-DQB1*03:02 haplotype but the alleles were in linkage disequilibrium and no independent effect could be detected. Within the DIPP cohort, neither the A*24:02 nor the B*39:01 allele were associated with seroconversion but were in contrast associated with increased progression from seroconversion to clinical disease. The independent predisposing effect of the HLA-B*39:06 allele with type 1 diabetes was confirmed in the Finnish population but the association of the A*24:02 and B*39:01 alleles remained inconclusive whilst both A*24:02 and B*39:01 affected the progression rate from seroconversion to autoantibody positivity to overt type 1 diabetes. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  11. Relationships among 64k Autoantibodies, Pancreatic β-cell Function, HLA-DR Antigens and HLA-DQ Genes in Patients with Insulin-Dependent Diabetes Mellitus in Korea

    Science.gov (United States)

    Lee, Hyun Chul; Cha, Bong Soo; Nam, Moon Suk; Song, Young Duk; Lim, Sung Kil; Kim, Duk Hi; Huh, Kap Bum; Koh, In Young

    1995-01-01

    Objectives Among autoantibodies detected in patients with insulin-dependent diabetes mellitus(IDDM), antibodies to 64,000Mr islet protein(64k), now recognized as glutamic acid decarboxy lase(GAD), appear to be an even more predictive marker of IDDM than islet cytoplasmic antibody(ICA) or insulin autoantibody(IAA). We examined the relationships among 64k autoantibodies, pancreatic β-cell function, HLA-DR antigens and HLA-DQ genes in patients with IDDM in Korea. Methods To identify the 64k autoantibody, the immunoprecipitation method was performed for 35 patients with IDDM and 10 normal controls. In patients with IDDM, serum C-peptide levels were measured and HLA-DR typings and HLA-DQA1 and DQB1 gene typings were performed. Results 12 of 35(34%) patients with IDDM were positive for 64k autoantibody in contrast to none of 10(0%) normal controls. There were no differences in residual pancreatic β-cell function between 64k autoantibody positive and negative groups. 64k autoantibody was detected more frequently in patients with recent(durationHLA-DQA1*0301, HLA-DQB1*0201, DQB1*0302 and DQB1*0303 gene types were higher in patients with 64k autoantibody (12/12[100%]) vs. without 64k autoantibody 18/22[81%], 5/11[45%] vs. without 64k autoantibody 5/22[23%], 5/11[45%] vs. without 64k autoantibody 8/22[36%] and 6/11[55%] vs. without 64k autoantibody 9/22[41%]. Conclusions There results suggest that 64k autoantibodies have some relationship with HLA-DR, DQA1 and DQB1 genes, but not with residual pancreatic β-cell function in Korean patients with IDDM. PMID:7626550

  12. Principal contribution of HLA-DQ alleles, DQB1*06:04 and DQB1*03:01, to disease resistance against primary biliary cholangitis in a Japanese population.

    Science.gov (United States)

    Yasunami, Michio; Nakamura, Hitomi; Tokunaga, Katsushi; Kawashima, Minae; Nishida, Nao; Hitomi, Yuki; Nakamura, Minoru

    2017-09-11

    Identification of the primary allele(s) in HLA class II associated diseases remains challenging because of a tight linkage between alleles of HLA-DR and -DQ loci. In the present study, we determined the genotypes of seven HLA loci (HLA-A, -B, -DRB1, -DQA1, -DQB1, -DPA1 and -DPB1) for 1200 Japanese patients with primary biliary cholangitis and 1196 controls. Observation of recombination derivatives facilitated an evaluation of the effects of individual HLA alleles consisting of disease-prone/disease-resistant HLA haplotypes. Consequently, a primary contribution of DQB1*06:04 (odds ratio: 0.19, p = 1.91 × 10 -22 ), DQB1*03:01 (odds ratio: 0.50, p = 6.76 × 10 -10 ), DRB1*08:03 (odds ratio: 1.75, p = 1.01 × 10 -7 ) and DQB1*04:01 (odds ratio: 1.50, p = 9.20 × 10 -6 ) was suggested. Epistasis of the protective DQB1*06:04 to risk conferred by DRB1*08:03 was demonstrated by subpopulation analysis, implicating the presence of an active immunological mechanism that alleviates pathogenic autoimmune reactions. Further, the contribution of the aforementioned HLA alleles as well as an HLA-DP allele, DPB1*02:01 to the association signals of 304 loci among 4103 SNPs in the HLA region at the genome-wide level of significance (p values less than 5 × 10 -8 ) was demonstrated by the stepwise exclusion of the individuals possessing these HLA alleles from the comparison.

  13. [Intermediate/high energy nuclear physics

    International Nuclear Information System (INIS)

    1989-01-01

    We have continued to develop a theoretical framework for the quark and gluon structure of nuclei. Our approach features a successful phenomenological model, the quark cluster model (QCM), and an ambitious program in the non-perturbative solution of quantum field theories. The effort in quantum field theory provides theoretical results to test or replace assumed ingredients of the QCM. By the explicit example of a scalar field theory in 2D we have solved the long-standing problem of how to treat the dynamics of the vacuum in light-front quantization. We now propose to solve the same problem for simple Fermion field theories in 2D such as the Gross-Neveu model. We propose in subsequent years to address QCD in low dimensionality with the purpose of extracting non-perturbative predictions for quark and gluon amplitudes in few baryon systems. Simultaneously with this new effort we will continue to develop extensions and applications of the QCM. We propose to continue predicting phenomena to be observed in high energy particle-nucleus collisions that reflect the rearrangement of quarks and gluons in nuclei. We have completed our analysis of the SLAC E101 and E133 experiments on Deuterium to elucidate the degree to which a six-quark cluster contribution is admissable in the Bjorken x > 1 data. We have completed our development of a parameterized thermal liquid drop model for light nuclei. In addition we have completed a set of predictions for the formation of a ''nuclear stratosphere'' in nuclei created by intermediate energy heavy ion interactions. These results motivate a new investigation of the temperature dependence of the ion-ion potential with particular emphasis on the thermal dependence of the barrier height and radius. We have also shown that a consistent treatment of relativistic effects is important for a theoretical description of the elastic magnetic form factor of 17 O. 85 refs

  14. Intermediate Syndrome Following Organophosphate Insecticide Poisoning

    Directory of Open Access Journals (Sweden)

    Chen-Chang Yang

    2007-11-01

    Full Text Available Acute organophosphate insecticide poisoning can manifest 3 different phases of toxic effects, namely, acute cholinergic crisis, intermediate syndrome (IMS, and delayed neuropathy. Among them, IMS has been considered as a major contributing factor of organophosphate-related morbidity and mortality because of its frequent occurrence and probable consequence of respiratory failure. Despite a high incidence, the pathophysiology that underlies IMS remains unclear. Previously proposed mechanisms of IMS include different susceptibility of various cholinergic receptors, muscle necrosis, prolonged acetylcholinesterase inhibition, inadequate oxime therapy, downregulation or desensitization of postsynaptic acetylcholine receptors, failure of postsynaptic acetylcholine release, and oxidative stress-related myopathy. The clinical manifestations of IMS typically occur within 24 to 96 hours, affecting conscious patients without cholinergic signs, and involve the muscles of respiration, proximal limb muscles, neck flexors, and muscles innervated by motor cranial nerves. With appropriate therapy that commonly includes artificial respiration, complete recovery develops 5–18 days later. Patients with atypical manifestations of IMS, especially a relapse or a continuum of acute cholinergic crisis, however, were frequently reported in clinical studies of IMS. The treatment of IMS is mainly supportive. Nevertheless, because IMS generally concurs with severe organophosphate toxicity and persistent inhibition of acetylcholinesterase, early aggressive decontamination, appropriate antidotal therapy, and prompt institution of ventilatory support should be helpful in ameliorating the magnitude and/or the incidence of IMS. Although IMS is well recognized as a disorder of neuromuscular junctions, its exact etiology, incidence, and risk factors are not clearly defined because existing studies are largely small-scale case series and do not employ a consistent and rigorous

  15. Intermediate frequency magnetic field and chick embryotoxicity.

    Science.gov (United States)

    Nishimura, Izumi; Tanaka, Keiko; Negishi, Tadashi

    2013-09-01

    Intermediate frequency magnetic fields (MFs) have widely been used in industrial machines and home appliances, such as induction heating cookers, although toxicity studies to evaluate the potential health risks of such fields are insufficient. In induction heating cookers, the MF source (i.e. hobs), is located near the abdominal position of a person cooking. Hence, developmental effects on the fetus may be a concern in case the person is a pregnant woman. Fertile White Leghorn eggs (60/group) were either exposed to 20 kHz, 1.1 mT(rms) or 60 kHz, 0.11 mT(rms) sinusoidal MFs for 19 days during embryogenesis. The same number of eggs served as a control group. In addition, a sham-sham experiment was conducted to validate the equality between exposure and control facilities. After exposure, embryos were examined for mortality rate and stage. Live embryos were evaluated for developmental stage and gross and skeletal anomalies. Length of upper beak and leg digits was also measured. Examinations were conducted in a blinded fashion to ensure quality assurance; experiments were triplicated for each frequency to confirm the outcome reproducibility. Mortality rate and stage, incidence of malformed embryos, and developmental variables in live embryos were found to be similar between the MF-exposed and corresponding control group. Incidence of gross anomalies such as mandibular edema and skeletal anomalies such as coccyx defects were low across the experiments, and no significant group differences were noted. In conclusion, exposure to 20 kHz or 60 kHz MF did not produce any significant teratogenic developmental effects in chick embryos. © 2013 The Authors. Congenital Anomalies © 2013 Japanese Teratology Society.

  16. The polarized platypus polarized neutron reflectometry made possible

    International Nuclear Information System (INIS)

    Saerbeck, Thomas

    2009-01-01

    Full text: The magnetic moment of the neutron, together with it's highly penetrating non destructive manner, make polarized neutron reflectometry an excellent tool to study magnetic phenomena across surfaces and interfaces of thin films. Unlike other magnetometry techniques which ordinarily yield only average magnetization values or, in case of probes with higher spatial resolution (e.g. electron microscopy or scanning tunnelling microscopy), show a high surface sensitivity, PNR together with magnetic x-ray scattering provides the ability to spatially resolve vector magnetization well beneath the surface [1] The ability to obtain vector magnetization profiles across interfaces and surfaces of thin films and multilayers offers the intriguing possibility to study systematically magnetic configurations and magnetic exchange interactions through intervening layers. In this paper we present the performance of the new polarization system installed on the time of flight neutron reflectometer PLATYPUS at ANSTO's Bragg Institute. The spin state of the neutrons is polarized and analysed by spatial separation of different neutron spin states using polarizing Fe/Si supermirrors before, and after the sample stage. The supermirrors have a large wavelength acceptance bandwidth of 3 A to 12 A. To control the desired spin direction of the incoming and reflected beam from the sample, two sets of RF spin flippers are installed. In the free space between the spin flippers and the sample stage the neutron spin direction is maintained by two sets of magnetic guide field coils. The new sample environment for studies of magnetic samples includes a 1 T electromagnet and a closed cycle refrigerator which gives access to a temperature range from 4K to 3 50 K .

  17. Polarized few-nucleon targets: new developments

    International Nuclear Information System (INIS)

    Haeusser, O.

    1992-09-01

    We discuss recent improvements in producing polarized few-nucleon targets for nuclear and particle physics experiments. The emphasis is on progress with polarized gas targets intended for experiments at electron and proton storage rings. (author) 54 refs., 1 tab

  18. {tau} polarization in SUSY cascade decays

    Energy Technology Data Exchange (ETDEWEB)

    Choi, S.Y. [Chonbuk Univ., Jeonju (Korea), Dept. of Physics and RIPC]|[Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Hagiwara, K. [KEK National High Energy Physics, Tsukuba (Japan); Kim, Y.G. [Sejong Univ., Seoul (Korea). ARCSEC; Mawatari, K. [Korea Institute for Advanced Study, Seoul (Korea). School of Physics; Zerwas, P.M. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)]|[KEK National High Energy Physics, Tsukuba (Japan)

    2006-12-15

    {tau} leptons emitted in cascade decays of supersymmetric particles are polarized. The polarization may be exploited to determine spin and mixing properties of the neutralinos and stau particles involved. (orig.)

  19. Summary of the polarized beam working group

    International Nuclear Information System (INIS)

    Wienands, U.; Dyck, O. van.

    1989-05-01

    The polarized beam working group reviewed the AGS Bookster and TRIUMF KAON Factory facilities, heard an overview of the subject of siberian snakes, discussed internal polarized gas targets, and made recommendations for further study

  20. Orientation and mobility of actin in different intermediate states of the ATP hydrolysis cycle.

    Science.gov (United States)

    Khaimina, S S; Wrzosek, A; Dabrowska, R; Borovikov, Yu S

    2005-10-01

    Using polarization fluorimetry, we have investigated conformational changes of FITC-phalloidin-labeled F-actin in ghost muscle fibers. These changes were induced by myosin subfragment-1 (S1) in the absence and presence of MgADP, MgAMP-PNP, MgATPgammaS, or MgATP. Modeling of various intermediate states was accompanied by discrete changes in actomyosin orientation and mobility of fluorescent dye dipoles. This suggests multistep changes of orientation and mobility of actin monomers during the ATPase cycle. The most pronounced differences in orientation (~4 degrees ) and in mobility (~43%) of actin were found between the actomyosin states induced by MgADP and MgATP.