WorldWideScience

Sample records for interlocking aggregates

  1. The Utilisation of Shredded PET as Aggregate Replacement for Interlocking Concrete Block

    Science.gov (United States)

    Mokhtar, M.; Kaamin, M.; Sahat, S.; Hamid, N. B.

    2018-03-01

    The consumption of plastic has grown substantially all over the world in recent years and this has created huge quantities of plastic-based waste. Plastic waste is now a serious environmental threat to the modern way of living, although steps were taken to reduce its consumption. This creates substantial garbage every day, which is much unhealthy. Plastic bottles such as Polyethylene terephthalate (PET) was use as the partially component in this making of interlocking blocks concrete. This project investigates the strength and workability of the interlocking block concrete by replacing course aggregate with % PET. The suitability of recycled plastics (PET) as course aggregate in interlocking block concrete and its advantages are discussed here. Moreover, there were more benefits when using interlocking block than using conventional block such as it easy for construction because they are aligning, easy to place, high speed stacking and they offer more resistance to shear and buildings would be even stronger. Based on the test perform, the failure parameter were discussed .From the compressive strength test result, it shows that the strength of concrete block decreased with increased of PET used. From the results, it shows that higher compressive strength was found with 5% natural course aggregate replaced with PET compared to other percentages.

  2. Interlocking wettable ceramic tiles

    Science.gov (United States)

    Tabereaux, Jr., Alton T.; Fredrickson, Guy L.; Groat, Eric; Mroz, Thomas; Ulicny, Alan; Walker, Mark F.

    2005-03-08

    An electrolytic cell for the reduction of aluminum having a layer of interlocking cathode tiles positioned on a cathode block. Each tile includes a main body and a vertical restraining member to prevent movement of the tiles away from the cathode block during operation of the cell. The anode of the electrolytic cell may be positioned about 1 inch from the interlocking cathode tiles.

  3. Alcohol ignition interlock programs.

    Science.gov (United States)

    Beirness, D J; Marques, P R

    2004-09-01

    The alcohol ignition interlock is an in-vehicle DWI control device that prevents a car from starting until the operator provides a breath alcohol concentration (BAC) test below a set level, usually .02% (20 mg/dl) to .04% (40 mg/dl). The first interlock program was begun as a pilot test in California 18 years ago; today all but a few US states, and Canadian provinces have interlock enabling legislation. Sweden has recently implemented a nationwide interlock program. Other nations of the European Union and as well as several Australian states are testing it on a small scale or through pilot research. This article describes the interlock device and reviews the development and current status of interlock programs including their public safety benefit and the public practice impediments to more widespread adoption of these DWI control devices. Included in this review are (1) a discussion of the technological breakthroughs and certification standards that gave rise to the design features of equipment that is in widespread use today; (2) a commentary on the growing level of adoption of interlocks by governments despite the judicial and legislative practices that prevent more widespread use of them; (3) a brief overview of the extant literature documenting a high degree of interlock efficacy while installed, and the rapid loss of their preventative effect on repeat DWI once they are removed from the vehicles; (4) a discussion of the representativeness of subjects in the current research studies; (5) a discussion of research innovations, including motivational intervention efforts that may extend the controlling effect of the interlock, and data mining research that has uncovered ways to use the stored interlock data record of BAC tests in order to predict high risk drivers; and (6) a discussion of communication barriers and conceptual rigidities that may be preventing the alcohol ignition interlock from taking a more prominent role in the arsenal of tools used to control

  4. Modelling Railway Interlocking Systems

    DEFF Research Database (Denmark)

    Lindegaard, Morten Peter; Viuf, P.; Haxthausen, Anne Elisabeth

    2000-01-01

    In this report we present a model of interlocking systems, and describe how the model may be validated by simulation. Station topologies are modelled by graphs in which the nodes denote track segments, and the edges denote connectivity for train traÆc. Points and signals are modelled by annotatio...

  5. Interlocked systems in nanomedicine.

    Science.gov (United States)

    Ornelas-Megiatto, Catia; Becher, Tiago B; Megiatto, Jackson D

    2015-01-01

    The concept of Nanomedicine emerged along with the new millennium, and it is expected to provide solutions to some of modern medicine's unsolved problems. Nanomedicine offers new hopes in several critical areas such as cancer treatment, viral and bacterial infections, medical imaging, tissue regeneration, and theranostics. To explore all these applications, a wide variety of nanomaterials have been developed which include liposomes, dendrimers, nanohydrogels and polymeric, metallic and inorganic nanoparticles. Recently, interlocked systems, namely rotaxanes and catenanes, have been incorporated into some of these chemical platforms in an attempt to improve their performance. This review focus on the nanomedicine applications of nanomaterials containing interlocked structures. The introduction gives an overview on the significance of interdisciplinary science in the progress of the nanomedicine field, and it explains the evolution of interlocked molecules until their application in nanomedicine. The following sections are organized by the type of interlocked structure, and it comprises details of the in vitro and/or in vivo experiments involving each material: rotaxanes as imaging agents, rotaxanes as cytotoxic agents, rotaxanes as peptide transporters, mechanized silica nanoparticles as stimuli responsive drug delivery systems, and polyrotaxanes as drug and gene delivery systems.

  6. FRACTURE SHAFT HUMERUS: INTERLOCKING

    Directory of Open Access Journals (Sweden)

    Deepak Kaladagi

    2014-12-01

    Full Text Available BACKGROUND: The incidence of humeral fracture has significantly increased during the present years due to the population growth and road traffic, domestic, industrial, automobile accidents & disasters like tsunami, earthquakes, head-on collisions, polytrauma etc. In order to achieve a stable fixation followed by early mobilization, numerous surgical implants have been devised. PURPOSE: The purpose of this study is to analyze the results of intramedullary fixation of proximal 2/3rd humeral shaft fractures using an unreamed interlocking intramedullary nail. INTRODUCTION: In 40 skeletally matured patients with fracture shaft of humerus admitted in our hospital, we used unreamed antegrade interlocking nails. MATERIAL: We carried out a prospective analysis of 40 patients randomly selected between 2001 to 2014 who were operated at JNMC Belgaum, MMC Mysore & Navodaya Medical College, Raichur. All cases were either RTAs, Domestic, Industrial, automobile accidents & also other modes of injury. METHOD: Routine investigations with pre-anaesthetic check-up & good quality X-rays of both sides of humerus was taken. Time of surgery ranged from 5-10 days from the time of admission. Only upper 1/3rd & middle 1/3rd humeral shaft fractures were included in the study. In all the cases antegrade locked unreamed humeral nails were inserted under C-arm. Patient was placed in supine position & the shoulder was kept elevated by placing a sandbag under the scapula. In all patients incision taken from tip of acromion to 3cm over deltoid longitudinally. Postoperatively sling applied with wrist & shoulder movements started after 24 hours. All the patients ranged between the age of 21-50 years. RESULTS: Total 40 patients were operated. Maximum fracture site were in the middle third- 76%, 14% upper 1/3rd. All 40 patients achieved union. The average time of union was 8-10 weeks. All patients regained full range of movements except in few cases, where there was shoulder

  7. 49 CFR 236.751 - Interlocking, manual.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Interlocking, manual. 236.751 Section 236.751 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Interlocking, manual. An arrangement of signals and signal appliances operated from an interlocking machine and...

  8. Interlocking directorships in Polish joint stock companies:

    OpenAIRE

    Pawlak, Marek

    2008-01-01

    Studies concerning interlocking directorships have been carried out among Polish joint stock corporations. The main source of data have been the announcements that are to be published by corporations regularly in a journal called Business and Court Gazette (BCG). Interlocking directorships constitute a network among corporations the use of which enables co-ordinated management of the whole group. The phenomenon of interlocking directorships in Polish joint stock companies can be compared to t...

  9. Coastal protection using topological interlocking blocks

    Science.gov (United States)

    Pasternak, Elena; Dyskin, Arcady; Pattiaratchi, Charitha; Pelinovsky, Efim

    2013-04-01

    The coastal protection systems mainly rely on the self-weight of armour blocks to ensure its stability. We propose a system of interlocking armour blocks, which form plate-shape assemblies. The shape and the position of the blocks are chosen in such a way as to impose kinematic constraints that prevent the blocks from being removed from the assembly. The topological interlocking shapes include simple convex blocks such as platonic solids, the most practical being tetrahedra, cubes and octahedra. Another class of topological interlocking blocks is so-called osteomorphic blocks, which form plate-like assemblies tolerant to random block removal (almost 25% of blocks need to be removed for the assembly to loose integrity). Both classes require peripheral constraint, which can be provided either by the weight of the blocks or post-tensioned internal cables. The interlocking assemblies provide increased stability because lifting one block involves lifting (and bending) the whole assembly. We model the effect of interlocking by introducing an equivalent additional self-weight of the armour blocks. This additional self-weight is proportional to the critical pressure needed to cause bending of the interlocking assembly when it loses stability. Using beam approximation we find an equivalent stability coefficient for interlocking. It is found to be greater than the stability coefficient of a structure with similar blocks without interlocking. In the case when the peripheral constraint is provided by the weight of the blocks and for the slope angle of 45o, the effective stability coefficient for a structure of 100 blocks is 33% higher than the one for a similar structure without interlocking. Further increase in the stability coefficient can be reached by a specially constructed peripheral constraint system, for instance by using post-tension cables.

  10. Macro-Micro Interlocked Simulator

    International Nuclear Information System (INIS)

    Sato, Tetsuya

    2005-01-01

    Simulation Science is now standing on a turning point. After the appearance of the Earth Simulator, HEC is struggling with several severe difficulties due to the physical limit of LSI technologies and the so-called latency problem. In this paper I would like to propose one clever way to overcome these difficulties from the simulation algorithm viewpoint. Nature and artificial products are usually organized with several nearly autonomously working internal systems (organizations, or layers). The Earth Simulator has gifted us with a really useful scientific tool that can deal with the entire evolution of one internal system with a sufficient soundness. In order to make a leap jump of Simulation Science, therefore, it is desired to design an innovative simulator that enables us to deal with simultaneously and as consistently as possible a real system that evolves cooperatively with several internal autonomous systems. Three years experience of the Earth Simulator Project has stimulated to come up with one innovative simulation algorithm to get rid of the technological barrier standing in front of us, which I would like to call 'Macro-Micro Interlocked Algorithm', or 'Macro-Micro Multiplying Algorithm', and present a couple of such examples to validate the proposed algorithm. The first example is an aurora-arc formation as a result of the mutual interaction between the macroscopic magnetosphere-ionosphere system and the microscopic field-aligned electron and ion system. The second example is the local heavy rain fall resulting from the interaction between the global climate evolution and the microscopic raindrop growth process. Based on this innovative feasible algorithm, I came up with a Macro-Micro Multiplying Simulator

  11. Comparing formal verification approaches of interlocking systems

    DEFF Research Database (Denmark)

    Haxthausen, Anne Elisabeth; Nguyen, Hoang Nga; Roggenbach, Markus

    2016-01-01

    The verification of railway interlocking systems is a challenging task, and therefore several research groups have suggested to improve this task by using formal methods, but they use different modelling and verification approaches. To advance this research, there is a need to compare...... these approaches. As a first step towards this, in this paper we suggest a way to compare different formal approaches for verifying designs of route-based interlocking systems and we demonstrate it on modelling and verification approaches developed within the research groups at DTU/Bremen and at Surrey...

  12. SaRDIn - A Safe Reconfigurable Distributed Interlocking

    DEFF Research Database (Denmark)

    Fantechi, Alessandro; Gnesi, S.; Haxthausen, Anne Elisabeth

    2016-01-01

    Current computer-based interlocking systems most often have a centralized design, with all logic residing in a single computer. Centralized interlockings are complex to design. Following the general trend in Cyber-Physical Systems, the SaRDIn (Safe Reconfigurable Distributed Interlockings) concept...

  13. 21 CFR 876.4590 - Interlocking urethral sound.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Interlocking urethral sound. 876.4590 Section 876...) MEDICAL DEVICES GASTROENTEROLOGY-UROLOGY DEVICES Surgical Devices § 876.4590 Interlocking urethral sound. (a) Identification. An interlocking urethral sound is a device that consists of two metal sounds...

  14. Automated generation of formal safety conditions from railway interlocking tables

    DEFF Research Database (Denmark)

    Haxthausen, Anne Elisabeth

    2014-01-01

    This paper describes a tool for extracting formal safety conditions from interlocking tables for railway interlocking systems. The tool has been applied to generate safety conditions for the interlocking system at Stenstrup station in Denmark, and the SAL model checker tool has been used to check...

  15. Modelling and Verification of Relay Interlocking Systems

    DEFF Research Database (Denmark)

    Haxthausen, Anne Elisabeth; Bliguet, Marie Le; Kjær, Andreas

    2010-01-01

    This paper describes how relay interlocking systems as used by the Danish railways can be formally modelled and verified. Such systems are documented by circuit diagrams describing their static layout. It is explained how to derive a state transition system model for the dynamic behaviour of a re...

  16. Effectiveness and complications of SIGN intramedullary interlocking ...

    African Journals Online (AJOL)

    Background: Interlocking intramedullary nailing is the current state-of-the-art management of the shaft fractures of long bones. Objective: To assess the functional outcome of SIGN nailing of femoral and tibial fractures at Moi Teaching and Referral Hospital. Design: Retrospective analytical, study over a three year period ...

  17. Radiation safety interlocks at the NSLS

    International Nuclear Information System (INIS)

    Dickinson, T.

    1985-07-01

    The function of the NSLS interlock systems is to insure that no one is in an area where there is hazardous radiation, and to turn off the radiation source if a person somehow gains access to such an area. The interlock systems for the high hazard areas meet the following design requirements: (1) The system is redundant, that is no single failure can render the system unsafe. This is done by providing 2 independent systems or circuits; (2) In so far as possible, the two circuits are physically different. This minimizes the possibility of related coincident failures; (3) The design is fail safe. This means that the most likely failure modes leave the system in a safe condition. For example, the following failures are safe: Loss of power in any part of the system, any combination of shorts to ground, and any combination of open circuits; and (4) The interlock system must be testable. Redundancy sometimes makes testing difficult, but testing schemes must be worked out, since an untested interlock is undependable

  18. Any Monotone Function Is Realized by Interlocked Polygons

    Directory of Open Access Journals (Sweden)

    Erik D. Demaine

    2012-03-01

    Full Text Available Suppose there is a collection of n simple polygons in the plane, none of which overlap each other. The polygons are interlocked if no subset can be separated arbitrarily far from the rest. It is natural to ask the characterization of the subsets that makes the set of interlocked polygons free (not interlocked. This abstracts the essence of a kind of sliding block puzzle. We show that any monotone Boolean function ƒ on n variables can be described by m = O(n interlocked polygons. We also show that the decision problem that asks if given polygons are interlocked is PSPACE-complete.

  19. Application software for new BEPC interlock system

    International Nuclear Information System (INIS)

    Tang Shuming; Na Xiangyin; Chen Jiansong; Yu Yulan

    1997-01-01

    New BEPC (Beijing electron Positron collider) interlock system has been built in order to improve the reliability of personnel safety and interlock functions. Moreover, the system updates BEPC operation message once every 6 seconds, which are displayed on TV screens at the major entrances. Since March of 1996, new BEPC interlock system has been operating reliably. The hardware of the system is based on Programmable Logic Controllers (PLC). A multimedia IBM/PC-586 as the host computer of the PLCs, monitors the PLC system via serial port COM2. The PC communicates with the central computer VAX-4500 of BEPC control system and gets operating massage of the accelerator through serial port COM3. The application software on the host computer has been developed. Visual C++ for MS-Windows 3.2 TM is selected as the work bench. It provides nice tools for building programs, such as APP STUDIO, CLASS WIZARD, APP WIZARD and debugger tool. The author describes the design idea and the structure of the application software. Error tolerance is taken into consideration. The author also presents a small database and its data structure for the application

  20. Beam Interlocks for LHC and SPS

    CERN Document Server

    Dinius, A; Gimeno-Vicente, J; Nouchi, P; Puccio, B; Schmidt, R; Wenninger, J

    2003-01-01

    The Large Hadron Collider at CERN (LHC) will operate at 7 TeV/c with a luminosity of 10 cms. This requires two beams with about 3^10 protons/beam, corresponding to a stored energy of about 350 MJ, sufficient to heat and melt 500 kg of copper. Protection of equipment from damage in case of uncontrolled beam losses is challenging. Injection of the beam from the SPS to the LHC could already damage equipment and is only permitted when all LHC systems are correctly prepared. In case of an uncontrolled loss of the circulating LHC beams, it is required to extract the beams into a specially designed target as soon as possible. Beam loss monitors and equipment for hardware surveillance are distributed around the 26 km long accelerator. In case of failures or beam losses, the beam interlock system is informed and sends a dump request to the beam dumping system. The beam interlock system also inhibits injection when the LHC is not ready for beam. In this paper the requirements for the beam interlock system are discussed...

  1. INTERFIRM COOPERATION AND INFORMATION SHARING THROUGH INTERLOCKING DIRECTORATES

    Directory of Open Access Journals (Sweden)

    Mohammed Belal UDDIN

    2012-01-01

    Full Text Available When firms engage in cooperative efforts, interfirm relations get particular interest to be studied. A direct interlock occurs when an executive or director of one firm sits on the board of another firm, and an indirect interlock occurs when two firms have directors or executives who sit on the board of a third firm. The three commonly used theoretical models such as social network theory, learning theory, and theory of strategic choice are more relevant for the formation and management of interlocking directorates. Uncertainty, resource scarcity, mutual trust, dependency, etc. influence the formation of interlocking directorates. Consequently, interlocking directorates allow sharing of information and overall cooperation between partners through learning, collaboration, networking, and effective relationship, etc. Proper management of interlocking directorates requires communication and collaboration among partners that enhance exchange of knowledge and cooperation.

  2. Beam-limiting and radiation-limiting interlocks

    International Nuclear Information System (INIS)

    Macek, R.J.

    1996-01-01

    This paper reviews several aspects of beam-limiting and radiation- limiting interlocks used for personnel protection at high-intensity accelerators. It is based heavily on the experience at the Los Alamos Neutron Science Center (LANSCE) where instrumentation-based protection is used extensively. Topics include the need for ''active'' protection systems, system requirements, design criteria, and means of achieving and assessing acceptable reliability. The experience with several specific devices (ion chamber-based beam loss interlock, beam current limiter interlock, and neutron radiation interlock) designed and/or deployed to these requirements and criteria is evaluated

  3. Beam-limiting and radiation-limiting interlocks

    Energy Technology Data Exchange (ETDEWEB)

    Macek, R.J.

    1996-04-01

    This paper reviews several aspects of beam-limiting and radiation- limiting interlocks used for personnel protection at high-intensity accelerators. It is based heavily on the experience at the Los Alamos Neutron Science Center (LANSCE) where instrumentation-based protection is used extensively. Topics include the need for ``active`` protection systems, system requirements, design criteria, and means of achieving and assessing acceptable reliability. The experience with several specific devices (ion chamber-based beam loss interlock, beam current limiter interlock, and neutron radiation interlock) designed and/or deployed to these requirements and criteria is evaluated.

  4. Formal modelling and verification of interlocking systems featuring sequential release

    DEFF Research Database (Denmark)

    Vu, Linh Hong; Haxthausen, Anne Elisabeth; Peleska, Jan

    2017-01-01

    In this article, we present a method and an associated toolchain for the formal verification of the new Danish railway interlocking systems that are compatible with the European Train Control System (ETCS) Level 2. We have made a generic and reconfigurable model of the system behaviour and generic...... safety properties. This model accommodates sequential release - a feature in the new Danish interlocking systems. To verify the safety of an interlocking system, first a domain-specific description of interlocking configuration data is constructed and validated. Then the generic model and safety...

  5. Interlocking Nailing Versus Interlocking Plating in Intra-articular Calcaneal Fractures: A Biomechanical Study.

    Science.gov (United States)

    Reinhardt, Sophia; Martin, Heiner; Ulmar, Benjamin; Döbele, Stefan; Zwipp, Hans; Rammelt, Stefan; Richter, Martinus; Pompach, Martin; Mittlmeier, Thomas

    2016-08-01

    Open reduction and internal fixation with a plate is deemed to represent the gold standard of surgical treatment for displaced intra-articular calcaneal fractures. Standard plate fixation is usually placed through an extended lateral approach with high risk for wound complications. Minimally invasive techniques might avoid wound complications but provide limited construct stability. Therefore, 2 different types of locking nails were developed to allow for minimally invasive technique with sufficient stability. The aim of this study was to quantify primary stability of minimally invasive calcaneal interlocking nail systems in comparison to a variable-angle interlocking plate. After quantitative CT analysis, a standardized Sanders type IIB fracture model was created in 21 fresh-frozen cadavers. For osteosynthesis, 2 different interlocking nail systems (C-Nail; Medin, Nov. Město n. Moravě, Czech Republic; Calcanail; FH Orthopedics SAS; Heimsbrunn, France) as well as a polyaxial interlocking plate (Rimbus; Intercus GmbH; Rudolstadt, Germany) were used. Biomechanical testing consisted of a dynamic load sequence (preload 20 N, 1000 N up to 2500 N, stepwise increase of 100 N every 100 cycles, 0.5 mm/s) and a load to failure sequence (max. load 5000 N, 0.5 mm/s). Interfragmentary movement was detected via a 3-D optical measurement system. Boehler angle was measured after osteosynthesis and after failure occurred. No significant difference regarding load to failure, stiffness, Boehler angle, or interfragmentary motion was found between the different fixation systems. A significant difference was found with the dynamic failure testing sequence where 87.5% of the Calcanail implants failed in contrast to 14% of the C-Nail group (P plate. The highest load to failure was observed for the C-Nail. Boehler angle showed physiologic range with all implants before and after the biomechanical tests. Both minimally invasive interlocking nail systems displayed a high primary stability

  6. The SDUV-FEL vacuum interlock system

    International Nuclear Information System (INIS)

    Qi Binchuan; Zhu Haijun; Ding Jiangguo

    2011-01-01

    Shanghai Deep Ultraviolet Free Electron Laser (SDUV-FEL) test facility is an integrated multi-purpose test bed for FEL principles. In this paper, we focus on the development of an interlock system for SDUV-FEL vacuum protection. Hardware and software of the system implementations are introduced. A distributed control system composed of a PLC, an embedded computer and consoles based on EPICS toolkit is described in details. The system has been used for cascaded HGHG FEL experiment. Stability and reliability has been demonstrated. (authors)

  7. A DUAL NETWORK MODEL OF INTERLOCKING DIRECTORATES

    Directory of Open Access Journals (Sweden)

    Humphry Hung

    2003-01-01

    Full Text Available The article proposes an integrative framework for the study of interlocking directorates by using an approach that encompasses the concepts of multiple networks and resource endowment. This serves to integrate the traditional views of interorganizational linkages and intra-class cohesion. Through appropriate strategic analysis of relevant resource endowment of internal environment and external networks of organizations and corporate elites, this article argues that the selection of directors, if used effectively, can be adopted as a strategic device to enhance the corporation's overall performance.

  8. Formal Verification of the Danish Railway Interlocking Systems

    DEFF Research Database (Denmark)

    Vu, Linh Hong; Haxthausen, Anne Elisabeth; Peleska, Jan

    2014-01-01

    in the new Danish interlocking systems. Instantiating the generic model with interlocking configuration data results in a concrete model and high-level safety properties. Using bounded model checking and inductive reasoning, we are able to verify safety properties for model instances corresponding to railway...

  9. Applied Bounded Model Checking for Interlocking System Designs

    DEFF Research Database (Denmark)

    Haxthausen, Anne Elisabeth; Peleska, Jan; Pinger, Ralf

    2014-01-01

    In this paper the verification and validation of interlocking systems is investigated. Reviewing both geographical and route-related interlocking, the verification objectives can be structured from a perspective of computer science into (1) verification of static semantics, and (2) verification...

  10. Dual Interlocked Logic for Single-Event Transient Mitigation

    Science.gov (United States)

    2017-03-01

    Dual Interlocked Logic for Single -Event Transient Mitigation Jeffrey Maharrey, Jeffrey Kauppila, Dennis Ball, Timothy Holman, Lloyd Massengill...is shown to be robust to single event transients. Keywords: SET; CVSL; DIL; single event transient; hardened logic; cascode voltage switch; dual...interlocked Introduction Single event transients (SETs) generated in combinational logic are a major, often dominant, contributor to soft errors in

  11. A Domain-Specific Language for Railway Interlocking Systems

    DEFF Research Database (Denmark)

    Vu, Linh Hong; Haxthausen, Anne Elisabeth; Peleska, Jan

    2014-01-01

    This paper presents a domain-specific language (DSL) for describing route-based interlocking systems which are compatible with European Train Control System ETCS Level 2. The abstract syntax and static semantics of the language are formally defined using the RAISE Specification Language (RSL......). Furthermore, the paper describes an interlocking table generator (ITG) that generates automatically a well-formed interlocking table from a well-formed railway network layout. Experiments with the DSL and ITG using the RAISE tools and the C++ implementation show that the use of the DSL and ITG can increase...

  12. Synthesis of interlocked molecules by olefin metathesis

    Science.gov (United States)

    Clark, Paul Gregory

    A large body of work in the Grubbs group has focused on the development of functional-group tolerant ruthenium alkylidene catalysts that perform a number of olefin metathesis reactions. These catalysts have seen application in a wide range of fields, including classic total synthesis as well as polymer and materials chemistry. One particular family of compounds, interlocked molecules, has benefitted greatly from these advances in catalyst stability and activity. This thesis describes several elusive and challenging interlocked architectures whose syntheses have been realized through the utilization of different types of ruthenium-catalyzed olefin metathesis reactions. Ring-closing olefin metathesis has enabled the synthesis of a [c2]daisy-chain dimer with the ammonium binding site near the cap of the dimer. A deprotonated DCD possessing such a structural attribute will more forcefully seek to restore coordinating interactions upon reprotonation, enhancing its utility as a synthetic molecular actuator. Dimer functionalization facilitated incorporation into linear polymers, with a 48% size increase of an unbound, extended analogue of the polymer demonstrating slippage of the dimer units. Ongoing work is directed at further materials studies, in particular, exploring the synthesis of macroscopic networks containing the DCD units and analyzing the correlation between molecular-scale extension-contraction manipulations and resulting macro-scale changes. A "clipping" approach to a polycatenated cyclic polymer, a structure that resembles a molecular "charm bracelet", has been described. The use of ring-opening metathesis polymerization of a carbamate monomer in the presence of a chain transfer agent allowed for the synthesis of a linear polymer that was subsequently functionalized and cyclized to the corresponding cyclic analogue. This cyclic polymer was characterized through a variety of techniques, and subjected to further functionalization reactions, affording a cyclic

  13. Fracture Union in Closed Interlocking Nail in Humeral Shaft Fractures

    Directory of Open Access Journals (Sweden)

    Ramji Lal Sahu

    2015-01-01

    Conclusions: The results of the present study indicates that in the presence of proper indications, reamed antegrade intramedullary interlocked nailing appears to be a method of choice for internal fixation of osteoporotic and pathologic fractures.

  14. Compositional Verification of Multi-Station Interlocking Systems

    DEFF Research Database (Denmark)

    Macedo, Hugo Daniel dos Santos; Fantechi, Alessandro; Haxthausen, Anne Elisabeth

    2016-01-01

    Because interlocking systems are highly safety-critical complex systems, their automated safety verification is an active research topic investigated by several groups, employing verification techniques to produce important cost and time savings in their certification. However, such systems also...

  15. Interlock system for the COMPASS tokamak

    Czech Academy of Sciences Publication Activity Database

    Hron, Martin; Sova, J.; Šíba, J.; Kovář, J.; Adámek, Jiří; Pánek, Radomír; Havlíček, Josef; Písačka, Jan; Mlynář, Jan; Stöckel, Jan

    2010-01-01

    Roč. 85, 3-4 (2010), s. 505-508 ISSN 0920-3796. [IAEA Technical Meeting on Control, Data Acquisition and Remote Participation for Fusion Research/7th./. Aix – en – Provence, 15.06.2009-19.06.2009] R&D Projects: GA MŠk 7G09042; GA ČR GD202/08/H057 Institutional research plan: CEZ:AV0Z20430508 Keywords : Tokamak operation * Interlock * Personnel safety Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 1.143, year: 2010 http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6V3C-5003BXW-1&_user=6542793&_coverDate=07%2F31%2F2010&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000070123&_version=1&_urlVersion=0&_userid=6542793&md5=ef5794d05cc6530a905d1de43aa0ac6a&searchtype=a

  16. Artificial nanomachines based on interlocked molecules

    International Nuclear Information System (INIS)

    Credi, Alberto

    2006-01-01

    The extension of the concept of machine to the molecular level is of great interest for the growth of nanoscience and the development of nanotechnology. A molecular machine can be defined as an assembly of a discrete number of molecular components (that is, a supramolecular structure) designed to perform a function through the mechanical movements of its components, which occur under appropriate external stimulation. Hence, molecular machines contain a motor part, that is a device capable of converting energy into mechanical work. Molecular motors and machines operate via nuclear rearrangements and, like their macroscopic counterparts, are characterized by the kind of energy input supplied to make them work, the manner in which their operation can be monitored, the possibility to repeat the operation at will, i.e., establishing a cyclic process, the timescale needed to complete a cycle of operation, and the performed function. Owing to the progresses made in several branches of chemistry, and to the better understanding of the operation mechanisms of molecular machines of the biological world, it has become possible to design and construct simple prototypes of artificial molecular motors and machines. Some examples based on rotaxanes, catenanes, and related interlocked molecules will be described

  17. Alcohol ignition interlock programmes for reducing drink driving recidivism.

    Science.gov (United States)

    Willis, C; Lybrand, S; Bellamy, N

    2004-10-18

    An ignition interlock device is part of a multi-dimensional programme aimed at reducing recidivism in convicted drink drivers. To operate a vehicle equipped with an ignition interlock device, the driver must first provide a breath specimen. If the breath alcohol concentration of the specimen exceeds the predetermined level, the vehicle will not start. As a measure to reduce circumvention of the device (i.e. someone else blows into the mouthpiece), random retests are required while the vehicle is running. Other components of the drink driving programme include information seminars for the driver and downloading data from the device's data logger, which logs all test attempts and records all passes, warnings and failures. To systematically assess the effectiveness of ignition interlock programmes on recidivism rates of drink drivers, by examining rates of recidivism while the ignition interlock device was installed in the vehicle and after removal of the device. The Cochrane Controlled Trials Register was searched, in addition to relevant electronic databases and the Internet. Controlled trials in which offenders have been charged with drink driving and have either been sentenced to participate in an ignition interlock programme or the usual punishment (either licence suspension or some form of treatment programme). This study was not restricted by language or status of publication. One randomised controlled trial (RCT) and ten controlled trials were identified, and also three ongoing trials. Data regarding recidivism while the interlock is installed in the vehicle; after the interlock has been removed from the vehicle and total recidivism during the study were extracted and entered into analyses using RevMan. The RCT showed that the interlock programme was effective while the device was installed in the vehicle; relative risk 0.36 (95% confidence interval 0.21 to 0.63). Controlled trials support this conclusion, with a general trend - in both first-time and repeat

  18. Hierarchical Porous Interlocked Polymeric Microcapsules: Sulfonic Acid Functionalization as Acid Catalysts

    Science.gov (United States)

    Wang, Xiaomei; Gu, Jinyan; Tian, Lei; Zhang, Xu

    2017-03-01

    Owing to their unique structural and surface properties, mesoporous microspheres are widely applied in the catalytic field. Generally, increasing the surface area of the specific active phase of the catalyst is a good method, which can achieve a higher catalytic activity through the fabrication of the corresponding catalytic microspheres with the smaller size and hollow structure. However, one of the major challenges in the use of hollow microspheres (microcapsules) as catalysts is their chemical and structural stability. Herein, the grape-like hypercrosslinked polystyrene hierarchical porous interlocked microcapsule (HPIM-HCL-PS) is fabricated by SiO2 colloidal crystals templates, whose structure is the combination of open mouthed structure, mesoporous nanostructure and interlocked architecture. Numerous microcapsules assembling together and forming the roughly grape-like microcapsule aggregates can enhance the structural stability and recyclability of these microcapsules. After undergoing the sulfonation, the sulfonated HPIM-HCL-PS is served as recyclable acid catalyst for condensation reaction between benzaldehyde and ethylene glycol (TOF = 793 h-1), moreover, exhibits superior activity, selectivity and recyclability.

  19. Outcome of intramedullary interlocking SIGN nail in tibial diaphyseal fracture

    International Nuclear Information System (INIS)

    Khan, I.; Javed, S.; Khan, G.N.; Aziz, A.

    2013-01-01

    Objective: To determine the outcome of intramedullary interlocking surgical implant generation network (SIGN) nail in diaphyseal tibial fractures in terms of union and failure of implant (breakage of nail or interlocking screws). Study Design: Case series. Place and Duration of Study: Orthopaedics and Spinal Surgery, Ghurki Trust Teaching Hospital, Lahore Medical and Dental College, Lahore, from September 2008 to August 2009. Methodology: Fifty patients aged 14 - 60 years, of either gender were included, who had closed and Gustilo type I and II open fractures reported in 2 weeks, whose closed reduction was not possible or was unsatisfactory and fracture was located 7 cm below knee joint to 7 cm above ankle joint. Fractures previously treated with external fixator, infected fractures and unfit patients were excluded. All fractures were fixed with intramedullary interlocking SIGN nail and were followed clinically and radiographically for union and for any implant failure. Results: Forty one (88%) patients had united fracture within 6 months, 5 (10%) patients had delayed union while 4 (8%) patients had non-union. Mean duration for achieving union was 163 + 30.6 days. Interlocking screws were broken in 2 patients while no nail was broken in any patient. Conclusion: Intramedullary interlocking nailing is an effective measure in treating closed and grade I and II open tibial fractures. It provides a high rate of union less complications and early return to function. (author)

  20. Adaptive mechanical properties of topologically interlocking material systems

    International Nuclear Information System (INIS)

    Khandelwal, S; Siegmund, T; Cipra, R J; Bolton, J S

    2015-01-01

    Topologically interlocked material systems are two-dimensional granular crystals created as ordered and adhesion-less assemblies of unit elements of the shape of platonic solids. The assembly resists transverse forces due to the interlocking geometric arrangement of the unit elements. Topologically interlocked material systems yet require an external constraint to provide resistance under the action of external load. Past work considered fixed and passive constraints only. The objective of the present study is to consider active and adaptive external constraints with the goal to achieve variable stiffness and energy absorption characteristics of the topologically interlocked material system through an active control of the in-plane constraint conditions. Experiments and corresponding model analysis are used to demonstrate control of system stiffness over a wide range, including negative stiffness, and energy absorption characteristics. The adaptive characteristics of the topologically interlocked material system are shown to solve conflicting requirements of simultaneously providing energy absorption while keeping loads controlled. Potential applications can be envisioned in smart structure enhanced response characteristics as desired in shock absorption, protective packaging and catching mechanisms. (paper)

  1. Applied Bounded Model Checking for Interlocking System Designs

    DEFF Research Database (Denmark)

    Haxthausen, Anne Elisabeth; Peleska, Jan; Pinger, Ralf

    2013-01-01

    In this article the verification and validation of interlocking systems is investigated. Reviewing both geographical and route-related interlocking, the verification objectives can be structured from a perspective of computer science into (1) verification of static semantics, and (2) verification...... of behavioural (operational) semantics. The former checks that the plant model – that is, the software components reflecting the physical components of the interlocking system – has been set up in an adequate way. The latter investigates trains moving through the network, with the objective to uncover potential...... safety violations. From a formal methods perspective, these verification objectives can be approached by theorem proving, global, or bounded model checking. This article explains the techniques for application of bounded model checking techniques, and discusses their advantages in comparison...

  2. Poly[n]catenanes: Synthesis of molecular interlocked chains

    Science.gov (United States)

    Wu, Qiong; Rauscher, Phillip M.; Lang, Xiaolong; Wojtecki, Rudy J.; de Pablo, Juan J.; Hore, Michael J. A.; Rowan, Stuart J.

    2017-12-01

    As the macromolecular version of mechanically interlocked molecules, mechanically interlocked polymers are promising candidates for the creation of sophisticated molecular machines and smart soft materials. Poly[n]catenanes, where the molecular chains consist solely of interlocked macrocycles, contain one of the highest concentrations of topological bonds. We report, herein, a synthetic approach toward this distinctive polymer architecture in high yield (~75%) via efficient ring closing of rationally designed metallosupramolecular polymers. Light-scattering, mass spectrometric, and nuclear magnetic resonance characterization of fractionated samples support assignment of the high-molar mass product (number-average molar mass ~21.4 kilograms per mole) to a mixture of linear poly[7-26]catenanes, branched poly[13-130]catenanes, and cyclic poly[4-7]catenanes. Increased hydrodynamic radius (in solution) and glass transition temperature (in bulk materials) were observed upon metallation with Zn2+.

  3. Design of a dependable Interlock System for linear colliders

    CERN Document Server

    Nouvel, Patrice

    For high energy accelerators, the interlock system is a key part of the machine protection. The interlock principle is to inhibit the beam either on failure of critical equipment and/or on low beam quality evaluation. The dependability of such a system is the most critical parameter. This thesis presents the design of an dependable interlock system for linear collider with an application to the CLIC (Compact Linear Collider) project. This design process is based on the IEEE 1220 standard and is is divided in four steps. First, the specifications are established, with a focus on the dependability, more precisely the reliability and the availability of the system. The second step is the design proposal based on a functional analysis, the CLIC and interfaced systems architecture. Third, the feasibility study is performed, applying the concepts in an accelerator facility. Finally, the last step is the hardware verification. Its aim is to prove that the proposed design is able to reach the requirements.

  4. RF generator interlock by plasma grid bias current - An alternate to Hα interlock

    Science.gov (United States)

    Bandyopadhyay, M.; Gahlaut, A.; Yadav, R. K.; Pandya, K.; Tyagi, H.; Vupugalla, M.; Bhuyan, M.; Bhagora, J.; Chakraborty, A.

    2017-08-01

    ROBIN is inductively coupled plasma (ICP) based negative hydrogen ion source, operated with a 100kW, 1MHz Tetrode based RF generator (RFG). Inductive plasma ignition by the RFG in ROBIN is associated with electron seeding by a hot filament and a gas puff. RFG is triggered by the control system to deliver power just at the peak pressure of the gas puff. Once plasma is ignited due to proper impedance matching, a bright light, dominated by Hα (˜656nm wavelength) radiation is available inside RF driver which is used as a feedback signal to the RFG to continue its operation. If impedance matching is not correct, plasma is not produced due to lack of power coupling and bright light is not available. During such condition, reflected RF power may damage the RFG. Therefore, to protect the RFG, it needs to be switched off automatically within 200ms by the control system in such cases. This plasma light based RFG interlock is adopted from BATMAN ion source. However, in case of vacuum immersed RF ion source in reactor grade NBI system, such plasma light based interlock may not be feasible due to lack of adequate optical fiber interfaces. In reactor grade NBI system, neutron and gamma radiations have impact on materials which may lead to frequent maintenance and machine down time. The present demonstration of RFG interlock by Bias Current (BC) in ROBIN testbed gives an alternate option in this regard. In ROBIN, a bias plate (BP) is placed in the plasma chamber near the plasma grid (PG). BP is electrically connected to the plasma chamber wall of the ion source and PG is isolated from the wall. A high current ˜85 A direct current (DC) power supply of voltage in the range of 0 - 33V is connected between the PG and the BP in such a way that PG can be biased positively with respect to the BP or plasma chamber. This arrangement is actually made to absorb electrons and correspondingly reduce co-extracted electron current during beam extraction. However, in case of normal plasma

  5. 12 CFR 212.9 - Effect of Interlocks Act on Clayton Act.

    Science.gov (United States)

    2010-01-01

    ... MANAGEMENT OFFICIAL INTERLOCKS § 212.9 Effect of Interlocks Act on Clayton Act. The Board regards the provisions of the first three paragraphs of section 8 of the Clayton Act (15 U.S.C. 19) to have been... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Effect of Interlocks Act on Clayton Act. 212.9...

  6. 49 CFR 236.312 - Movable bridge, interlocking of signal appliances with bridge devices.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Movable bridge, interlocking of signal appliances with bridge devices. 236.312 Section 236.312 Transportation Other Regulations Relating to... SYSTEMS, DEVICES, AND APPLIANCES Interlocking Standards § 236.312 Movable bridge, interlocking of signal...

  7. A Domain-Specific Language for Railway Interlocking Systems

    DEFF Research Database (Denmark)

    Vu, Linh Hong; Haxthausen, Anne Elisabeth; Peleska, Jan

    2014-01-01

    This paper presents a domain-specific language (DSL) for describing route-based interlocking systems which are compatible with European Train Control System ETCS Level 2. The abstract syntax and static semantics of the language are formally defined using the RAISE Specification Language (RSL...

  8. Board and auditor interlocks and voluntary disclosure in annual reports

    NARCIS (Netherlands)

    Braam, G.J.M.; Borghans, L.

    2014-01-01

    Purpose – The purpose of this study is to explore whether interlock ties between the board of directors and the external auditors facilitate the cross-firm diffusion of voluntary disclosures in annual reports. Design/methodology/approach – Using a sample of 149 non-financial companies publicly

  9. Automatic Verification of Railway Interlocking Systems: A Case Study

    DEFF Research Database (Denmark)

    Petersen, Jakob Lyng

    1998-01-01

    This paper presents experiences in applying formal verification to a large industrial piece of software. The are of application is railway interlocking systems. We try to prove requirements of the program controlling the Swedish railway Station Alingsås by using the decision procedure which is ba...

  10. Charging/Safety-Interlock Connection For Capacitor Bank

    Science.gov (United States)

    Rippel, Wally E.

    1990-01-01

    Electrically controlled mechanical interlock apparatus prevents connection of bank of capacitors to battery or other dc power supply until capacitors precharged to nearly full supply voltage. Precharge eliminates excessive inrush current, which damages capacitors, wires, or connectors. Circuit in apparatus also discharges capacitors after power turned off or capacitors disconnected from power supply.

  11. National synchrotron light source medical personnel protection interlock

    International Nuclear Information System (INIS)

    Buda, S.; Gmur, N.F.; Larson, R.; Thomlinson, W.

    1998-01-01

    This report is founded on reports written in April 1987 by Robert Hettel for angiography operations at the Stanford Synchrotron Research Laboratory (SSRL) and a subsequent report covering angiography operations at the National Synchrotron Light Source (NSLS); BNL Informal Report 47681, June 1992. The latter report has now been rewritten in order to accurately reflect the design and installation of a new medical safety system at the NSLS X17B2 beamline Synchrotron Medical Research Facility (SMERF). Known originally as the Angiography Personnel Protection Interlock (APPI), this system has been modified to incorporate other medical imaging research programs on the same beamline and thus the name has been changed to the more generic Medical Personnel Protection Interlock (MPPI). This report will deal almost exclusively with the human imaging (angiography, bronchography, mammography) aspects of the safety system, but will briefly explain the modular aspects of the system allowing other medical experiments to be incorporated

  12. NATIONAL SYNCHROTRON LIGHT SOURCE MEDICAL PERSONNEL PROTECTION INTERLOCK

    Energy Technology Data Exchange (ETDEWEB)

    BUDA,S.; GMUR,N.F.; LARSON,R.; THOMLINSON,W.

    1998-11-03

    This report is founded on reports written in April 1987 by Robert Hettel for angiography operations at the Stanford Synchrotron Research Laboratory (SSRL) and a subsequent report covering angiography operations at the National Synchrotron Light Source (NSLS); BNL Informal Report 47681, June 1992. The latter report has now been rewritten in order to accurately reflect the design and installation of a new medical safety system at the NSLS X17B2 beamline Synchrotron Medical Research Facility (SMERF). Known originally as the Angiography Personnel Protection Interlock (APPI), this system has been modified to incorporate other medical imaging research programs on the same beamline and thus the name has been changed to the more generic Medical Personnel Protection Interlock (MPPI). This report will deal almost exclusively with the human imaging (angiography, bronchography, mammography) aspects of the safety system, but will briefly explain the modular aspects of the system allowing other medical experiments to be incorporated.

  13. Central system of Interlock of ITER, high integrity architecture

    International Nuclear Information System (INIS)

    Prieto, I.; Martinez, G.; Lopez, C.

    2014-01-01

    The CIS (Central Interlock System), along with the CODAC system and CSS (Central Safety System), form the central I and C systems of ITER. The CIS is responsible for implementing the core functions of protection (Central Interlock Functions) through different systems of plant (Plant Systems) within the overall strategy of investment protection for ITER. IBERDROLA supports engineering to define and develop the control architecture of CIS according to the stringent requirements of integrity, availability and response time. For functions with response times of the order of half a second is selected PLC High availability of industrial range. However, due to the nature of the machine itself, certain functions must be able to act under the millisecond, so it has had to develop a solution based on FPGA (Field Programmable Gate Array) capable of meeting the requirements architecture. In this article CIS architecture is described, as well as the process for the development and validation of the selected platforms. (Author)

  14. Design of modified safety interlock system for pelletron accelerator

    International Nuclear Information System (INIS)

    Yadav, M.L.; Lokare, R.N.; Matkar, U.V.; Ekambaram, M.; Gudekar, P.V.; Vishwakarma, Ramlal S.; Kulkarni, S.G.; Gore, J.A.; Gupta, A.K.; Datar, V.M.

    2013-01-01

    The BARC-TIFR Pelletron Accelerator Facility has been operational for last twenty four years progressively with increased efficiency, delivering energetic light and heavy ions at medium energy. The process of beam acceleration makes the accelerator tower and beam hall radiation prone areas. A modified Interlock system for Pelletron Accelerator has been designed and developed to ensure radiation safety of the personnel working in the accelerator premises. Radiation levels from monitors, status of search and secure switches and entry doors of the accelerator tower, are inputs to the interlock system. The system triggers if radiation level exceeds the set value or status of any search and secure switches and entry doors across the tower are changed, thus stopping the beam at ion source level. This system also incorporates new features like-audio visual alarm pertaining to each location. (author)

  15. Design of responsive materials using topologically interlocked elements

    International Nuclear Information System (INIS)

    Molotnikov, A; Gerbrand, R; Qi, Y; Simon, G P; Estrin, Y

    2015-01-01

    In this work we present a novel approach to designing responsive structures by segmentation of monolithic plates into an assembly of topologically interlocked building blocks. The particular example considered is an assembly of interlocking osteomorphic blocks. The results of this study demonstrate that the constraining force, which is required to hold the blocks together, can be viewed as a design parameter that governs the bending stiffness and the load bearing capacity of the segmented structure. In the case where the constraining forces are provided laterally using an external frame, the maximum load the assembly can sustain and its stiffness increase linearly with the magnitude of the lateral load applied. Furthermore, we show that the segmented plate with integrated shape memory wires employed as tensioning cables can act as a smart structure that changes its flexural stiffness and load bearing capacity in response to external stimuli, such as heat generated by the switching on and off an electric current. (paper)

  16. Availability Analysis of the Ventilation Stack CAM Interlock System

    CERN Document Server

    Young, J

    2000-01-01

    Ventilation Stack Continuous Air Monitor (CAM) Interlock System failure modes, failure frequencies, and system availability have been evaluated for the RPP. The evaluation concludes that CAM availability is as high as assumed in the safety analysis and that the current routine system surveillance is adequate to maintain this availability credited in the safety analysis, nor is such an arrangement predicted to significantly improve system availability.

  17. Interlocked intramedullary nailing for treatment of open femoral shaft fractures.

    Science.gov (United States)

    Baixauli, F; Baixauli, E J; Sánchez-Alepuz, E; Baixauli, F

    1998-05-01

    Twenty-eight patients with open femoral shaft fractures treated by reamed intramedullary nailing were reviewed retrospectively. Nine patients had Gustilo Grade I injuries; 14, Grade II; and five, Grade IIIA. Twenty cases had static locking, two cases had dynamic locking, and six cases were not locked. Average time to union was 20 weeks. The infection and nonunion rates were 0%. The data suggest that interlocked reamed intramedullary nailing is a safe treatment option for treating open femoral shaft fractures.

  18. External jig in the placement of distal interlocking screws | Ikem ...

    African Journals Online (AJOL)

    Retrograde (52.2%) was the commonest surgical approach used for femur. The main indication for SIGN interlocking surgery was recent fracture 77.8%. Open reduction 97.8% was the commonest method of reduction used. The mean±SD bone union time was 3.58±0.56 months and range 3-5 months. Distal screw insertion ...

  19. Modular safety interlock system for high energy physics experiments

    International Nuclear Information System (INIS)

    Kieffer, J.; Golceff, B.V.

    1980-10-01

    A frequent problem in electronics systems for high energy physics experiments is to provide protection for personnel and equipment. Interlock systems are typically designed as an afterthought and as a result, the working environment around complex experiments with many independent high voltages or hazardous gas subsystems, and many different kinds of people involved, can be particularly dangerous. A set of modular hardware has been designed which makes possible a standardized, intergrated, hierarchical system's approach and which can be easily tailored to custom requirements

  20. Neutral beam interlock system on TFTR using infrared pyrometry

    International Nuclear Information System (INIS)

    Medley, S.S.; Kugel, H.W.; Kozub, T.A.; Lowrance, J.L.; Mastrocola, V.; Renda, G.; Young, K.M.

    1986-01-01

    Although the region of the Tokamak Fusion Test Reactor (TFTR) vacuum vessel wall which is susceptible to damage by neutral beam strike is armored with a mosaic of TiC-clad POCO graphite tiles, at power deposition levels above 2.5 kW/cm 2 the armor surface temperature exceeds 1200 0 C within 250 ms, and itself becomes susceptible to damage. In order to protect the wall armor, a neutral beam interlock system based on infrared pyrometry measurement of the armor surface temperature was installed on TFTR. For each beamline, a three-fiber-optic telescope views three areas of --30 cm diameter centered on the armor hot spots for the three ion sources. Each signal is fiber-optic coupled to a remote 900-nm pyrometer which feeds analog signals to the neutral beam interrupt circuits. The pyrometer interlock system is designed to interrupt each of the 12 ion sources independently within 10 ms of the temperature exceeding a threshold which can be set in the range of 500--2300 0 C. A description of the pyrometer interlock system and its performance will be presented

  1. Determinants of Board Interlocking in the Brazilian Capital Market

    Directory of Open Access Journals (Sweden)

    Flávio Ribeiro

    2016-10-01

    Full Text Available The objective in this article was to identify the main determinants of Board Interlocking in the Brazilian capital market. As the theoretical structure, the Agency theory and Corporate Governance, the Resource Dependence theory and the Board of Administrators and the Characteristics of Board Interlocking. The sample consists of 58 Brazilian companies that participate in the Bovespa Index (Ibovespa. An empirical analytic study was undertaken. With regard to the objectives, it is characterized as exploratory and, with regard to the procedures, a documentary research was undertaken. The data on the Boards of Administrators were collected from the Reference Forms available on the website of the São Paulo Stock Exchange (BM&FBOVESPA. The results found demonstrate the generalized presence of Board Interlocking in these companies, normally associated with four factors: (1 economic group formation; (2 governmental control; (3 formation of pension funds; and (4 presence of professionals with acknowledged market experience. The results also suggest that the first three factors give rise to long-lasting links and that these connections are hard to break. On the other hand, the links established through professionals with market experience tend to be more unstable because the presence of these professionals is highly demanded to serve on the board of different companies.

  2. Effects of Interlocking and Supporting Conditions on Concrete Block Pavements

    Science.gov (United States)

    Mahapatra, Geetimukta; Kalita, Kuldeep

    2018-02-01

    Concrete Block Paving (CBP) is widely used as wearing course in flexible pavements, preferably under light and medium vehicular loadings. Construction of CBP at site is quick and easy in quality control. Usually, flexible pavement design philosophy is followed in CBP construction, though it is structurally different in terms of small block elements with high strength concrete and their interlocking aspects, frequent joints and discontinuity, restrained edge etc. Analytical solution for such group action of concrete blocks under loading in a three dimensional multilayer structure is complex and thus, the need of conducting experimental studies is necessitated for extensive understanding of the load—deformation characteristics and behavior of concrete blocks in pavement. The present paper focuses on the experimental studies for load transfer characteristics of CBP under different interlocking and supporting conditions. It is observed that both interlocking and supporting conditions affect significantly on the load transfer behavior in CBP structures. Coro-lock block exhibits better performance in terms of load carrying capacity and distortion behavior under static loads. Plate load tests are performed over subgrade, granular sub-base (GSB), CBP with and without GSB using different block shapes. For an example case, the comparison of CBP with conventional flexible pavement section is also presented and it is found that CBP provides considerable benefit in terms of construction cost of the road structure.

  3. Achieving interlocking nails without using an image intensifier.

    Science.gov (United States)

    Ikem, Innocent C; Ogunlusi, Johnson D; Ine, Henry R

    2007-08-01

    Interlocking nails are commonly performed using an image intensifier. These are expensive and are not readily available in most resource-poor countries of the world. The aim of this study was to achieve interlocking nailing without the use of an image intensifier. This is a prospective descriptive analysis of 40 consecutive cases seen with shaft fractures of the humerus, femur, and tibia. Fracture fixation was done using Surgical Implant Generation Network (SIGN) nails. Forty limbs in 34 patients were studied. There were 12 females and 22 males, giving a ratio of 1:2. The mean age (years) was 35.75+/-13.16 and the range was 17-70 years. The studied bones were: humerus 10%, femur 65%, and tibia 25%. The fracture lines were: transverse 40%, oblique 15%, and communited 45%. Fracture grades were: closed 90%, grade I, 5%, grade II, 2.5%, and grade IIIA, 2.5%. Surgical approaches were: antegrade 62.5% and retrograde 37.5%. Indications for fixation were: recent fracture 92.5%, non-union 5%, and malunion 3%. Methods of reductions were: open 85% and closed 15%. The mean follow-up period (years) was 1.50+/-0.78. The union time averaged 3 months. Complication was mainly screw loosening due to severe osteoporoses in one case. It is, therefore, concluded that, with the aid of external jigs and slot finders, interlocking can be achieved without an image intensifier.

  4. Rydberg aggregates

    Science.gov (United States)

    Wüster, S.; Rost, J.-M.

    2018-02-01

    We review Rydberg aggregates, assemblies of a few Rydberg atoms exhibiting energy transport through collective eigenstates, considering isolated atoms or assemblies embedded within clouds of cold ground-state atoms. We classify Rydberg aggregates, and provide an overview of their possible applications as quantum simulators for phenomena from chemical or biological physics. Our main focus is on flexible Rydberg aggregates, in which atomic motion is an essential feature. In these, simultaneous control over Rydberg–Rydberg interactions, external trapping and electronic energies, allows Born–Oppenheimer surfaces for the motion of the entire aggregate to be tailored as desired. This is illustrated with theory proposals towards the demonstration of joint motion and excitation transport, conical intersections and non-adiabatic effects. Additional flexibility for quantum simulations is enabled by the use of dressed dipole–dipole interactions or the embedding of the aggregate in a cold gas or Bose–Einstein condensate environment. Finally we provide some guidance regarding the parameter regimes that are most suitable for the realization of either static or flexible Rydberg aggregates based on Li or Rb atoms. The current status of experimental progress towards enabling Rydberg aggregates is also reviewed.

  5. The influence of biocalcification on soil-cement interlocking block compressive strength

    Directory of Open Access Journals (Sweden)

    Yoosathaporn, S.

    2015-01-01

    Full Text Available Description of the subject. Soil-cement interlocking block is used as the building block for many civil structures in Thailand. The addition of many alternative materials into interlocking block in order to improve compressive strength has been reported. However, there is currently no report on the influence of application of biocalcification or microbiologically induced calcite precipitation (MICP on interlocking block compressive strength. Objectives. This study aimed to investigate the effect of biocalcification on compressive strength of soil-cement interlocking block. Method. Soil bacterium, Bacillus pasteurii KCTC 3558, and Effective Microorganisms (EM were added into interlocking block before molding as the replacement of mixing water. The change of compressive strength in interlocking block at 3, 7, 14 and 28 days of incubation was determined. Results. At 28 days, the compressive strength of interlocking block supplemented with B. pasteurii KCTC 3558 and 5% EM were 7.38% and 9.79% significantly higher than control. Calcium carbonate crystals were also observed under scanning electron microscope which suggested that an increased compressive strength of interlocking block was caused by biocalcification. Conclusions. Our results showed that microbiologically induced calcite precipitation could help increasing the compressive strength of soil-cement interlocking block.

  6. Construction aggregates

    Science.gov (United States)

    Tepordei, V.V.

    1994-01-01

    Part of a special section on industrial minerals in 1993. The 1993 production of construction aggregates increased 6.3 percent over the 1992 figure, to reach 2.01 Gt. This represents the highest estimated annual production of combined crushed stone and construction sand and gravel ever recorded in the U.S. The outlook for construction aggregates and the issues facing the industry are discussed.

  7. National Synchrotron Light Source angiography personnel protection interlock

    International Nuclear Information System (INIS)

    Gmuer, N.; Larson, R.; Thomlinson, W.

    1992-06-01

    This document has been written to describe the safety system operation at the NSLS X17B2 beamline Synchrotron Medical Research Facility (SMERF). The angiography exposure process involves scanning a patient up and down through dual fixed-position x-ray beams; exposure is controlled by opening and closing a fast-acting Safety Shutter mechanism at precise times in relation to the up and down motion of the scan chair. The fast-acting Safety Shutter mechanism is the primary radiation-stopping element protecting the patient while the chair is at rest and while it is reversing directions during the scan. Its fail-safe and fast operation is essential for the safety of the patient. Operation of X17B2 as a human subject angiography station necessitates the implementation of a personnel protection interlock system that, in conjunction with the Safety Shutters: permits safe access to the patient exposure area while the synchrotron radiation beam is illuminating the upstream dual energy monochromator; allows a patient to be imaged by the monochromatized beam under the supervision of a Responsible Physician, with scan chair motion and precision shutter actuation regulated by an angiography control computer, while providing a suitable number of safeguards against accidental radiation exposure; has different modes of operation to accommodate equipment set-up, test, and calibration; and patient exposure; and ensures the quick extinction of the beam if a potentially unsafe condition is detected. The interlock system which performs these safety functions is called the Angiography Personnel Protection Interlock (APPI). The APPI Document is organized such that the level of detail changes from a general overview to detailed engineering drawings of the hardware system

  8. National Synchrotron Light Source angiography personnel protection interlock

    Energy Technology Data Exchange (ETDEWEB)

    Gmuer, N.; Larson, R.; Thomlinson, W.

    1992-06-01

    This document has been written to describe the safety system operation at the NSLS X17B2 beamline Synchrotron Medical Research Facility (SMERF). The angiography exposure process involves scanning a patient up and down through dual fixed-position x-ray beams; exposure is controlled by opening and closing a fast-acting Safety Shutter mechanism at precise times in relation to the up and down motion of the scan chair. The fast-acting Safety Shutter mechanism is the primary radiation-stopping element protecting the patient while the chair is at rest and while it is reversing directions during the scan. Its fail-safe and fast operation is essential for the safety of the patient. Operation of X17B2 as a human subject angiography station necessitates the implementation of a personnel protection interlock system that, in conjunction with the Safety Shutters: permits safe access to the patient exposure area while the synchrotron radiation beam is illuminating the upstream dual energy monochromator; allows a patient to be imaged by the monochromatized beam under the supervision of a Responsible Physician, with scan chair motion and precision shutter actuation regulated by an angiography control computer, while providing a suitable number of safeguards against accidental radiation exposure; has different modes of operation to accommodate equipment set-up, test, and calibration; and patient exposure; and ensures the quick extinction of the beam if a potentially unsafe condition is detected. The interlock system which performs these safety functions is called the Angiography Personnel Protection Interlock (APPI). The APPI Document is organized such that the level of detail changes from a general overview to detailed engineering drawings of the hardware system.

  9. Model Checking Geographically Distributed Interlocking Systems Using UMC

    DEFF Research Database (Denmark)

    Fantechi, Alessandro; Haxthausen, Anne Elisabeth; Nielsen, Michel Bøje Randahl

    2017-01-01

    The current trend of distributing computations over a network is here, as a novelty, applied to a safety critical system, namely a railway interlocking system. We show how the challenge of guaranteeing safety of the distributed application has been attacked by formally specifying and model checking...... the relevant distributed protocols. By doing that we obey the safety guidelines of the railway signalling domain, that require formal methods to support the certification of such products. We also show how formal modelling can help designing alternative distributed solutions, while maintaining adherence...

  10. Shutdown channels and fitted interlocks in atomic reactors

    International Nuclear Information System (INIS)

    Furet, J.; Landauer, C.

    1968-01-01

    This catalogue consists of tables (one per reactor) giving the following information: number and type of detectors, range of the shutdown channels, nature of the associated electronics, thresholds setting off the alarms, fitted interlocks. These cards have been drawn up with a view to an examination of the reactors safety by the 'Reactor Safety Sub-Commission', they take into account the latest decisions. The reactors involved in this review are: Azur, Cabri, Castor-Pollux, Cesar-Marius-2, Edf-2, EL3, EL4, Eole, G1, G2-G3, Harmonie, Isis, Masurca, Melusine, Minerve, Osiris, Pegase, Peggy, PAT, Rapsodie, SENA, Siloe, Siloette, Triton-Nereide, and Ulysse. (authors) [fr

  11. Stable three-dimensional metallic carbon with interlocking hexagons.

    Science.gov (United States)

    Zhang, Shunhong; Wang, Qian; Chen, Xiaoshuang; Jena, Puru

    2013-11-19

    Design and synthesis of 3D metallic carbon that is stable under ambient conditions has been a long-standing dream. We predict the existence of such phases, T6- and T14-carbon, consisting of interlocking hexagons. Their dynamic, mechanical, and thermal stabilities are confirmed by carrying out a variety of state-of-the-art theoretical calculations. Unlike the previously studied K4 and the simple cubic high pressure metallic phases, the structures predicted in this work are stable under ambient conditions. Equally important, they may be synthesized chemically by using benzene or polyacenes molecules.

  12. Photovoltaic module and interlocked stack of photovoltaic modules

    Science.gov (United States)

    Wares, Brian S.

    2014-09-02

    One embodiment relates to an arrangement of photovoltaic modules configured for transportation. The arrangement includes a plurality of photovoltaic modules, each photovoltaic module including a frame. A plurality of individual male alignment features and a plurality of individual female alignment features are included on each frame. Adjacent photovoltaic modules are interlocked by multiple individual male alignment features on a first module of the adjacent photovoltaic modules fitting into and being surrounded by corresponding individual female alignment features on a second module of the adjacent photovoltaic modules. Other embodiments, features and aspects are also disclosed.

  13. Formal Development of a Tool for Automated Modelling and Verification of Relay Interlocking Systems

    DEFF Research Database (Denmark)

    Haxthausen, Anne Elisabeth; Kjær, Andreas A.; Le Bliguet, Marie

    2011-01-01

    This paper describes a tool for formal modelling relay interlocking systems and explains how it has been stepwise, formally developed using the RAISE method. The developed tool takes the circuit diagrams of a relay interlocking system as input and gives as result a state transition system modelling...

  14. 30 CFR 75.819 - Motor-starter enclosures; barriers and interlocks.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Motor-starter enclosures; barriers and...-Voltage Distribution High-Voltage Longwalls § 75.819 Motor-starter enclosures; barriers and interlocks. Compartment separation and cover interlock switches for motor-starter enclosures must be maintained in...

  15. 49 CFR 236.340 - Electromechanical interlocking machine; locking between electrical and mechanical levers.

    Science.gov (United States)

    2010-10-01

    ... between electrical and mechanical levers. 236.340 Section 236.340 Transportation Other Regulations... Electromechanical interlocking machine; locking between electrical and mechanical levers. In electro-mechanical interlocking machine, locking between electric and mechanical levers shall be maintained so that mechanical...

  16. Indus-2 machine safety interlock system - from design to commissioning

    International Nuclear Information System (INIS)

    Gothwal, Pankaj; Gupta, A.M.; Merh, B.; Fatnani, P.; Kumar, S.; Vaishnav, H.; Satheesan, T.V.

    2009-01-01

    INDUS-2 is a 2.5 GeV, 300 mA electron storage ring in operation at RRCAT, Indore. It is a one of its kind national facility with plans for 27 user beam lines from bending magnets. Any such large facility requires sufficient measures of machine safety besides occupational radiation safety during normal course of operation. In fact, machine safety is a major concern as any serious fault can cause expensive and extensive damage to machine components like magnets, vacuum chambers, vacuum valves etc. resulting in possibly long periods of machine shutdown. The machine has to clear many pre-checks to come to states of operation and certain conditions have to be maintained for operating it safely. The Machine Safety Interlock System (MSIS) must fulfil the normal requirements of a safety critical system. In the accelerator environment, such system must be easily configurable and expandable also. Therefore an intelligent computer based system has been developed and deployed. The INDUS-2 MSIS takes inputs from cooling water switches of photon absorbers and magnets, magnet coil temperatures, DCCT core temperature, vacuum sector valve status, door interlocks and search and scram system, integrated temperature status from vacuum chambers etc. The machine condition inputs to trip outputs relations are defined with equations. The paper presents the design basis, the system implementation details, performance issues and experiences. (author)

  17. Nonreamed interlocked intramedullary tibial nailing. One community's experience.

    Science.gov (United States)

    Duwelius, P J; Schmidt, A H; Rubinstein, R A; Green, J M

    1995-06-01

    Forty-nine acute displaced tibial fractures (31 closed, 18 open: 5 Grade I, 7 Grade II, 4 Grade IIIA, and 2 Grade IIIB) were treated in 1 community with a standard operative protocol using a distractor without a fracture table, and an unreamed interlocked tibial nail. Forty-six fractures healed (94%). Complications included 3 nonunions (6%), 2 deep infections (4%), 9 delayed unions (18%), 4 angular malunions (8%), 2 rotatory malunions (4%), and 12 interlocking screws bent or broke (24%). Twenty-eight patients (57%) required at least 1 additional operation to obtain union, most commonly dynamization of a statically locked nail. The authors conclude that unreamed tibial nails provide adequate stabilization of displaced tibial fractures and can be used in the management of most open or closed tibial fractures. However, static locking is required in axially unstable fractures. Early dynamization or exchange nailing and bone grafting should be considered to hasten union and avoid screw failure. The distractor is an excellent adjunctive technique for reduction and alignment of tibial shaft fractures during intramedullary nailing.

  18. Fracture Union in Closed Interlocking Nail in Femoral Fracture

    Directory of Open Access Journals (Sweden)

    R L Sahu

    2010-09-01

    Full Text Available INTRODUCTION: Fractures shaft femur is a major cause of morbidity and mortality in patients with lower extremity injuries. The objective of this study was to find out the outcome of Interlocking nail in fracture femur. METHODS: This study was conducted in the Department of Orthopaedic surgery in M. M. Medical College from July 2006 to November 2008. Seventy eight patients were recruited from Emergency and out patient department having closed fracture of femoral shaft. All patients were operated under general or spinal anesthesia. All patients were followed for nine months. RESULTS: Out of seventy eight patients, sixty nine patients underwent union in 90 to 150 days with a mean of 110.68 days. Touch down weight bearing was started on 2nd post-operative day. Complications found in four patients who had non-union, and five patients had delayed union which was treated with dynamization and bone graft. The results were excellent in 88.46% and good in 6.41% patients. CONCLUSIONS: We concluded that this technique is advantageous because of early mobilization (early weight bearing, less complication with good results and is economical. Keywords: close reamed interlocking nail, dynamization, femoral shaft fractures, union

  19. ROLES OF INTERLOCKING DIRECTORATES IN AN EMERGING COUNTRY: CONTROL AND COORDINATION IN FAMILY BUSINESS GROUPS

    Directory of Open Access Journals (Sweden)

    Aylin Ataay

    2016-04-01

    Full Text Available Maman (1999 proposed that, in countries in which business groups are dominant forms for organizing economic activities, the interlocking directorate is a managerial tool that can be prioritized to control and coordinate activities of their affiliated firms within the same groups and align their business objectives. This organizational connection appears to be an intentional strategy on the part of the groups‟ headquarters. In order to study the interlocking ties in Turkish family business groups (FBG, this study focused on interlocking directorates among listed firms in Turkey. The findings of preliminary study reveal that almost all of the interlocking ties were within the business groups (BG in our sample. This is the result of assignment of familyaffiliated and/or professional inside directors to the various boards of companies in the BG. We also found that compare to vertical ties; business groups are using more horizontal interlocking connections to bond their affiliated companies together.

  20. Software Development for Auto-Generation of Interlocking Knowledge base using Artificial Intelligence Approach

    Energy Technology Data Exchange (ETDEWEB)

    Ko, Yun Seok [Nanseoul University (Korea); Kim, JOng Sun [Kwangwoon University (Korea)

    1999-06-01

    This paper proposes IIKBAG (Intelligent Interlocking Knowledge Base Generator) which can build automatically the interlocking knowledge base utilized as the real-time interlocking strategy of the electronic interlocking system in order to enhance it's reliability and expansion. The IIKBAG consists of the inference engine and the knowledge base. The former has an auto-learning function which searches all the train routes for the given station model based on heuristic search technique while dynamically searching the model, and then generates automatically the interlocking patterns obtained from the interlocking relations of signal facilities on the routes. The latter is designed as the structure which the real-time expert system embedded on IS (Interlocking System) can use directly in order to enhances the reliability and accuracy. The IIKBAG is implemented in C computer language for the purpose of the build and interface of the station structure database. And, a typical station model is simulated to prove the validity of the proposed IIKBAG. (author). 13 refs., 5 figs., 2 tabs.

  1. Compressibility effects on double tearing mode interlocking in differentially rotating plasmas

    International Nuclear Information System (INIS)

    Wang, Xian-Qu; Wang, Zheng-Xiong; Wei, Lai; Xu, Wen-Bin

    2012-01-01

    Effects of compressibility on the double tearing modes (DTMs) in rotating plasmas are numerically investigated by using a compressible magnetohydrodynamics (MHD) model. It is found that due to the compressibility effects, the threshold of the interlocking magnetic island width in the slow and intermediate rotation regimes is larger than the counterpart in the incompressible plasmas. In the fast rotation regime, the compressible effect makes the DTM islands interlock more easily and faster. Moreover, in the very fast rotation regime, the plasma rotation can more effectively suppress the DTM islands. The scalings of the interlocking threshold in the different rotation regimes are obtained. Effects of plasma viscosity and beta on the DTM interlocking in the compressible plasmas are also discussed. -- Highlights: ► The threshold of the interlocking island width is larger than the counterpart in the incompressible plasmas. ► Compressible effect makes the islands interlock more easily and faster. ► The plasma rotation can more effectively suppress the DTM islands in the very fast rotation regime. ► Plasma beta effect on DTM interlocking is discussed.

  2. Availability Analysis of the Ventilation Stack CAM Interlock System

    International Nuclear Information System (INIS)

    YOUNG, J.

    2000-01-01

    Ventilation Stack Continuous Air Monitor (CAM) Interlock System failure modes, failure frequencies and system availability have been evaluated for the RPP. The evaluation concludes that CAM availability is as high as assumed in the safety analysis and that the current routine system surveillance is adequate to maintain this availability. Further, requiring an alarm to actuate upon CAM failure is not necessary to maintain the availability credited in the safety analysis, nor is such an arrangement predicted to significantly improve system availability. However, if CAM failures were only detected by the 92-day functional tests required in the Authorization Basis (AB), CAM availability would be much less than that credited in the safety analysis. Therefore it is recommended that the current surveillance practice of daily simple system checks, 30-day source checks and 92-day functional tests be continued in order to maintain CAM availability

  3. Structural damage monitoring of harbor caissons with interlocking condition

    Energy Technology Data Exchange (ETDEWEB)

    Huynh, Thanh Canh; Lee, So Young; Nauyen, Khac Duy; Kim, Jeong Tae [Pukyong National Univ., Busan (Korea, Republic of)

    2012-12-15

    The objective of this study is to monitor the health status of harbor caissons which have potential foundation damage. To obtain the objective, the following approaches are performed. Firstly, a structural damage monitoring(SDM) method is designed for interlocked multiple caisson structures. The SDM method utilizes the change in modal strain energy to monitor the foundation damage in a target caisson unit. Secondly, a finite element model of a caisson system which consists of three caisson units is established to verify the feasibility of the proposed method. In the finite element simulation, the caisson units are constrained each other by shear key connections. The health status of the caisson system against various levels of foundation damage is monitored by measuring relative modal displacements between the adjacent caissons.

  4. Structural damage monitoring of harbor caissons with interlocking condition

    International Nuclear Information System (INIS)

    Huynh, Thanh Canh; Lee, So Young; Nauyen, Khac Duy; Kim, Jeong Tae

    2012-01-01

    The objective of this study is to monitor the health status of harbor caissons which have potential foundation damage. To obtain the objective, the following approaches are performed. Firstly, a structural damage monitoring(SDM) method is designed for interlocked multiple caisson structures. The SDM method utilizes the change in modal strain energy to monitor the foundation damage in a target caisson unit. Secondly, a finite element model of a caisson system which consists of three caisson units is established to verify the feasibility of the proposed method. In the finite element simulation, the caisson units are constrained each other by shear key connections. The health status of the caisson system against various levels of foundation damage is monitored by measuring relative modal displacements between the adjacent caissons

  5. Communities detection as a tool to assess a reform of the Italian interlocking directorship network

    Science.gov (United States)

    Drago, Carlo; Ricciuti, Roberto

    2017-01-01

    Interlocking directorships are important communication channels among companies and may have anticompetitive effect. A corporate governance reform was introduced in 2011 to prevent interlocking directorships in the financial sector. We apply community detection techniques to the analysis of the networks in 2009 and 2012 to ascertain the effect of such reform on the Italian directorship network. We find that, although the number of interlocking directorships decreases in 2012, the reduction takes place mainly at the periphery of the network. The network core is stable, allowing the most connected companies to keep their strategic position.

  6. Interlock recovery during the drying, calcination and vitrification phase of Am/Cm processing

    International Nuclear Information System (INIS)

    Snyder, T.K.

    2000-01-01

    This document summarizes the results of five CIM5 [5-inch Cylindrical Induction Melter] runs designed to demonstrate power interlock recovery methods during the drying, calcination and vitrification phases of the Am/Cm melter cycle

  7. Incorporation of safety interlocks in commercial robotics for handling of nuclear materials

    International Nuclear Information System (INIS)

    Moore, F.W.

    1986-01-01

    The adaptation of commercial robotic systems to applications in the manufacturing of nuclear fuel has required the addition of safety interlocks as to the handling and accountability of nuclear materials. Also, additional safety interlocks are required when the robots are operated in containment enclosures that are environmentally sealed. Interlocks have been incorporated in a commercial robot which was modified and with additional interlocks into the existing robotic control system. The robotic system has been installed in the containment enclosure as part of the pellet storage subsystem in the Secure Automated Fabrication facility currently being built by Westinghouse Hanford Company for the US Department of Energy. The system has been installed in the Fuel Cycle Plant and is scheduled for initial operational testing in 1986

  8. 18 CFR 45.9 - Automatic authorization of certain interlocking positions.

    Science.gov (United States)

    2010-04-01

    ... owned, wholly or in part, by the other and, as its primary business, owns or operates transmission or... interlock involves affiliated public utilities. (b) Conditions of authorization. As a condition of...

  9. Compositional Model Checking of Interlocking Systems for Lines with Multiple Stations

    DEFF Research Database (Denmark)

    Macedo, Hugo Daniel dos Santos; Fantechi, Alessandro; Haxthausen, Anne Elisabeth

    2017-01-01

    In the railway domain safety is guaranteed by an interlocking system which translates operational decisions into commands leading to field operations. Such a system is safety critical and demands thorough formal verification during its development process. Within this context, our work has focused...... on the extension of a compositional model checking approach to formally verify interlocking system models for lines with multiple stations. The idea of the approach is to decompose a model of the interlocking system by applying cuts at the network modelling level. The paper introduces an alternative cut (the...... linear cut) to a previously proposed cut (border cut). Powered with the linear cut, the model checking approach is then applied to the verification of an interlocking system controlling a real-world multiple station line....

  10. CAMAC-based interlock system for power-supply-hardware protection on MFTF

    International Nuclear Information System (INIS)

    Strauch, M.S.

    1981-01-01

    This interlock module accepts 16 inputs and generates, in conjunction with an internal PROM map, 8 outputs. This decision process is autonomous of the CAMAC dataway and host computer. The map is generated, burned and verified by a user interactive program written to accept input/output equations in Boolean algebra. The interlock module requires the host computer to periodically interrogate it to verify proper operation of the module, host computer and date link; otherwise, permissives are dropped. An internal mask register may be used to override interlock inputs. This mask is perishable and must be constantly refreshed. Output drivers may be operated in a latch/no latch mode. This prevents outputs, once dropped, from being reasserted even if the proper input sequence is reestablished. A first-out register may be utilized to determine which input has dropped first in the event that chain reactions are developed among the interlock inputs

  11. Washington State's alcohol ignition interlock law: effects on recidivism among first-time DUI offenders.

    Science.gov (United States)

    McCartt, Anne T; Leaf, William A; Farmer, Charles M; Eichelberger, Angela H

    2013-01-01

    To examine the effects of changes to Washington State's ignition interlock laws: moving issuance of interlock orders from courts to the driver licensing department in July 2003 and extending the interlock order requirement to first-time offenders with blood alcohol concentrations (BACs) below 0.15 percent ("first simple driving under the influence [DUI]") in June 2004. Trends in conviction types, interlock installation rates, and 2-year cumulative recidivism rates were examined for first-time convictions (simple, high-BAC, test refusal DUI; deferred prosecution; alcohol-related negligent driving) stemming from DUI arrests between January 1999 and June 2006. Regression analyses examined recidivism effects of the law changes and interlock installation rates. To examine general deterrent effects, trends in single-vehicle late-night crashes in Washington were compared with trends in California and Oregon. After the 2004 law change, the proportion of simple DUIs declined somewhat, though the proportion of negligent driving convictions (no interlock order requirement) continued an upward trend. Interlock installation rates for first simple DUIs were 3 to 6 percent in the year before the law change and one third after. Recidivism declined by an estimated 12 percent (e.g., expected 10.6% without law change vs. 9.3% among offenders arrested between April and June 2006, the last study quarter) among first simple DUI offenders and an estimated 11 percent (expected 10.2% vs. 9.1%) among all first-time offenders. There was an estimated 0.06 percentage point decrease in the recidivism rate for each percentage point increase in the proportion of first simple DUI offenders with interlocks. If installation rates had been 100 vs. 34 percent for first simple DUI offenders arrested between April and June 2006, and if the linear relationship between rates of recidivism and installations continued, recidivism could have been reduced from 9.3 to 5.3 percent. With installation rates of

  12. A STUDY OF THE MANAGEMENT OF OPEN FRACTURES OF TIBIA BY UNREAMED INTERLOCKING NAIL

    OpenAIRE

    Kuppa Srinivas; Yerukala Ramana; Dema Rajaiah; Mohammad Akbar Khan; Sujith Omkaram; Venkateswar Reddy

    2015-01-01

    AIMS AND OBJECTIVES: To evaluate the results of closed interlocking intramedullary nailing without reaming in the treatment of open fractures of t he tibial shaft and study the difficulties (complications) encountered during the operative study. To compare the efficacy of interlocking intramedullary nailing without reaming in treating open fractures of tibia, Time required for the union of fracture, Range of motion of ankle and knee joint, Rate of malunion and mal rota...

  13. Radiation-free Insertion of Distal Interlocking Screw in Tibial and Femur Nailing: A Simple Technique

    OpenAIRE

    Soni, Ritesh Kumar; Mehta, Surender Mohan; Awasthi, Bhanu; Singh, Janith Lal; Kumar, Amit; Thakur, Lokesh; Tripathy, Sujit Kumar

    2012-01-01

    Background: Distal interlocking screw insertion in intramedullary nailing of long-bone fracture is a challenging task for orthopedic surgeons. It is difficult particularly when the surgeon is in his learning stage or when image intensifier is not available. We describe a radiation-free technique of distal interlocking screw insertion which is easy and practicable. Materials and Methods: In this technique, a same length nail is placed over the skin (outer nail) and through its distal-most scre...

  14. Governance of pension funds: interlocking and compensation of Australian superannuation fund boards

    OpenAIRE

    Ooi, Elizabeth Meishan

    2017-01-01

    This thesis documents the incidence and determinants of board interlocking (where directors simultaneously sit on multiple boards) in pension funds and examines its effect on fund performance. It also investigates the determinants of pension fund director compensation. The motivation to examine these issues stems from the distinctive interlocking and compensation practices in pension funds. Data on a sample of 249 Australian pension funds from 2004 to 2011 is collected from fund documents ...

  15. Strength properties of interlocking compressed earth brick units

    Science.gov (United States)

    Saari, S.; Bakar, B. H. Abu; Surip, N. A.

    2017-10-01

    This study presents a laboratory investigation on the properties of interlocking compressed earth brick (ICEB) units. Compressive strength, which is one of the most important properties in masonry structures, is used to determine masonry performance. The compressive strength of the ICEB units was determined by applying a compressive strength test for 340 units from four types of ICEB. To analyze the strength of the ICEB units, each unit was capped by a steel plate at the top and bottom to create a flat surface, and then ICEB was loaded until failure. The average compressive strength of the corresponding ICEB units are as follows: wall brick, 19.15 N/mm2; beam brick, 16.99 N/mm2; column brick, 13.18 N/mm2; and half brick, 11.79 N/mm2. All the ICEB units had compressive strength of over 5 N/mm2, which is the minimum strength for a load-bearing brick. This study proves that ICEB units may be used as load-bearing bricks. The strength of ICEBs is equal to that of other common bricks and blocks that are currently available in the market.

  16. Water absorption characteristic of interlocking compressed earth brick units

    Science.gov (United States)

    Bakar, B. H. Abu; Saari, S.; Surip, N. A.

    2017-10-01

    This study aims to investigate the water absorption characteristic of interlocking compressed earth brick (ICEB) units. Apart from compressive strength, water absorption is an important property in masonry. This property can affect the quality of the brick itself and the bond strength between the brick and mortar in masonry structures and can result in reducing its strength properties. The units were tested for 24 h water absorption and 5 h boiling water absorption. A total of 170 ICEB units from four ICEB types underwent both tests. For the 24 h water absorption, the ICEB units were dried in the oven for 24 h and then cooled before being weighed. Thereafter, each brick was immersed in water for 24 h and weighed. The same specimens used for the 24 h water absorption test were re-used for the 5 h boiling water absorption test. After completing the 24 h water absorption test, the brick was boiled for 5-hours and weighed. The highest water absorption for the ICEBs in the 24-hour water absorption and 5 h boiling water absorption tests are 15.09% and 17.18%, respectively. The half brick has the highest water absorption (15.87%), whereas the beam brick has the lowest (13.20%). The water absorption of an ICEB unit is higher than that of normal bricks, although the water absorption of the former remains below the maximum rate of the brick water absorption (21%).

  17. Interlocked by nanoscale sculpturing: pure aluminum copper contacts (Conference Presentation)

    Science.gov (United States)

    Gerngross-Baytekin, Melike; Gerngross, Mark Daniel; Carstensen, Jürgen; Adelung, Rainer

    2017-06-01

    Connecting metals reliable with different corrosion potential is a well-known challenge. An extreme example are copper aluminum contacts. Galvanic corrosion occurs if the two different metals are in contact with each other and an electrolyte, the aluminum becomes susceptible to corrosion under current flow. Usually, antioxidant pastes containing metals are employed but create difficulties e.g. for fatigue resistant power electronic connections. The recently described process of nanoscale sculpturing [1] offers an alternative. Usually, if the surface of metals like aluminium are prepared they are just arbitrary cuts through the bulk. There is no optimization of the surface grain structure towards stability at all. Neither the crystalline facets in the grains are in their most stable orientation nor is the protective oxide shell the most stable one. The nanoscale sculpturing approach is carving out the most stable grains and planes by chemical or electrochemical treatment. The decisive trick is that the chemistry is targeting towards the instable oxide and not the metal. Aluminium sample surfaces including alloys like AA575 exhibit afterwards single crystalline surface facets covered with nanoscale stable oxide films. Galvanically deposited copper forms extremely reliable interlocked connections on top, even allowing for soldering on top of their surface.

  18. Interlocking Corporate Directorates and the Global City Hierarchy

    Directory of Open Access Journals (Sweden)

    Jeffrey Kentor

    2015-08-01

    Full Text Available This paper examines the direct and indirect economic linkages of the most prominent cities in the world, those commonly referred to as “global cities”, in terms of the direct and indirect linkages of the boards of directors of Fortune Global 500 firms headquartered in a given city with boards of directors of other firms. Specifically, we identify the interlocks of corporate boards located within these major cities with other Fortune 500 boards of directors by degrees of separation, and present a new ranking for selected global cities based upon these direct and indirect ties. We find that New York clearly dominates these economic linkages, followed by London and Paris. This is most pronounced for financial companies. Contrary to other global city rankings, we locate Tokyo below Frankfurt and Chicago on this dimension. We argue that these multiple levels of indirect relationships reflect a significant, and until now unexplored, dimension of what it means to be a “global” city.

  19. Organometallic rotaxane dendrimers with fourth-generation mechanically interlocked branches

    Science.gov (United States)

    Wang, Wei; Chen, Li-Jun; Wang, Xu-Qing; Sun, Bin; Li, Xiaopeng; Zhang, Yanyan; Shi, Jiameng; Yu, Yihua; Zhang, Li; Liu, Minghua; Yang, Hai-Bo

    2015-01-01

    Mechanically interlocked molecules, such as catenanes, rotaxanes, and knots, have applications in information storage, switching devices, and chemical catalysis. Rotaxanes are dumbbell-shaped molecules that are threaded through a large ring, and the relative motion of the two components along each other can respond to external stimuli. Multiple rotaxane units can amplify responsiveness, and repetitively branched molecules—dendrimers—can serve as vehicles for assembly of many rotaxanes on single, monodisperse compounds. Here, we report the synthesis of higher-generation rotaxane dendrimers by a divergent approach. Linkages were introduced as spacer elements to reduce crowding and to facilitate rotaxane motion, even at the congested periphery of the compounds up to the fourth generation. The structures were characterized by 1D multinuclear (1H, 13C, and 31P) and 2D NMR spectroscopy, MALDI-TOF-MS, gel permeation chromatography (GPC), and microscopy-based methods including atomic force microscopy (AFM) and transmission electron microscopy (TEM). AFM and TEM studies of rotaxane dendrimers vs. model dendrimers show that the rotaxane units enhance the rigidity and reduce the tendency of these assemblies to collapse by self-folding. Surface functionalization of the dendrimers with ferrocenes as termini produced electrochemically active assemblies. The preparation of dendrimers with a well-defined topological structure, enhanced rigidity, and diverse functional groups opens previously unidentified avenues for the application of these materials in molecular electronics and materials science. PMID:25902491

  20. Recycled aggregates concrete: aggregate and mix properties

    OpenAIRE

    González-Fonteboa, B.; Martínez-Abella, F.

    2005-01-01

    This study of structural concrete made with recycled concrete aggregate focuses on two issues: 1. The characterization of such aggregate on the Spanish market. This involved conducting standard tests to determine density, water absorption, grading, shape, flakiness and hardness. The results obtained show that, despite the considerable differences with respect to density and water absorption between these and natural aggregates, on the whole recycled aggregate is apt for use in concrete produc...

  1. Intramedullary nailing of femoral shaft fractures. Part III: Long-term effects of static interlocking fixation.

    Science.gov (United States)

    Brumback, R J; Ellison, T S; Poka, A; Bathon, G H; Burgess, A R

    1992-01-01

    The results of treatment of fractures of the femoral shaft with static interlocking nailing were reviewed retrospectively to determine the clinical importance of any stress-riser or stress-shielding properties of the nail. These properties, if relevant, would have been manifested by refracture of the femur, either through a hole used for a locking screw or through the original site of fracture after extraction of the device. Two hundred and fourteen fractures that had been treated with static interlocking nailing and that had healed without conversion to dynamic intramedullary fixation were divided into two groups. In Group I, which comprised 111 fractures, the static interlocking-fixation device was retained and in Group II, which comprised 103 fractures, the static interlocking-fixation device was removed during one operative procedure at an average of fourteen months after the injury. The average duration of follow-up was thirty months from the time of the original fixation in both groups. All patients in Group II were followed for a minimum of six months after removal of the nail. No femur in Group I, in which the static interlocked nail remained in situ, refractured. No femur in either group fractured through the proximal or the distal holes used for the locking screws. No locking screws or nails broke. One patient (1 per cent) in Group II had a refracture of the femoral shaft through the site of the original fracture six weeks after removal of the nail.(ABSTRACT TRUNCATED AT 250 WORDS)

  2. Evaluation and application of a fast module in a PLC based interlock and control system

    Energy Technology Data Exchange (ETDEWEB)

    Zaera-Sanz, M [Department of Physics, Mathematics and Computer Science, Higher School of Technical Sciences CEU, Universidad Cardenal Herrera, Valencia (Spain)], E-mail: manzaesan@yahoo.es

    2009-08-15

    The LHC Beam Interlock system requires a controller performing a simple matrix function to collect the different beam dump requests. To satisfy the expected safety level of the Interlock, the system should be robust and reliable. The PLC is a promising candidate to fulfil both aspects but too slow to meet the expected response time which is of the order of {mu}seconds. Siemens has introduced a 'so called' fast module (FM352-5 Boolean Processor). It provides independent and extremely fast control of a process within a larger control system using an onboard processor, a Field Programmable Gate Array (FPGA), to execute code in parallel which results in extremely fast scan times. It is interesting to investigate its features and to evaluate it as a possible candidate for the beam interlock system. This paper publishes the results of this study. As well, this paper could be useful for other applications requiring fast processing using a PLC.

  3. Evaluation of a fast PLC module in prospect of the LHC beam interlock system

    CERN Document Server

    Zaera-Sanz, Manuel

    2005-01-01

    The LHC Beam Interlock system requires a controller performing a simple matrix function to collect the different beam dump requests. To satisfy the expected safety level of the Interlock, the system should be robust and reliable. The PLC is a promising candidate to fulfil both aspects but too slow to meet the expected response time which is of the order of mseconds. Siemens has introduced a “so called” fast module (FM352-5 Boolean Processor) that provides independent and extremely fast control of a process within a larger control system using an onboard processor, a Field Programmable Gate Array (FPGA), to execute code in parallel which results in extremely fast scan times. It is interesting to investigate its features and to evaluate it as a possible candidate for the beam interlock system. This note publishes the results of this study. As well, this note could be useful for other applications requiring fast processing using a PLC.

  4. The Impact of Board Interlocks on Auditor Choice and Audit Fees

    DEFF Research Database (Denmark)

    Riise Johansen, Thomas; Pettersson, Kim

    2013-01-01

    Research Question/Issue This paper uses unique Danish data to examine whether non-executive directors draw on both direct and indirect ties in the network of interlocking directorates to impact auditor choice, and whether this impact has consequences for audit fees. Research Findings/Insight The ......Research Question/Issue This paper uses unique Danish data to examine whether non-executive directors draw on both direct and indirect ties in the network of interlocking directorates to impact auditor choice, and whether this impact has consequences for audit fees. Research Findings...... of the non-executive director–auditor relationship and the role that board networks have in governing auditor choice decisions. The study identifies interlocks as an infrastructure for differentiation in the audit market and determines that such differentiation is associated with an audit fee premium...

  5. Ulnar interlocking intramedullary nail stabilization of a proximal radio-ulnar fracture in a dog.

    Science.gov (United States)

    Gatineau, Matthieu; Planté, Jérôme

    2010-12-01

    To report use of an ulnar interlocking intramedullary nail for repair of an open highly comminuted fracture of the proximal third of the antebrachium in a dog, caused by gunshot. Case report. 1.5-year old, 60 kg, neutered male Mastiff. An ulnar interlocking intramedullary nail was used to stabilize an open comminuted proximal antebrachial fracture and a cast applied for 4 weeks. Union by secondary bone healing occurred in 8 weeks. At 16 weeks, there was advanced remodeling of the radial and ulnar bony callus and fracture lines were no longer evident. Limb use was normal with normal pain free range of motion of the right elbow. Ulnar interlocking nail is a viable alternative treatment for highly comminuted fracture of the proximal third of the antebrachium in dogs. © Copyright 2010 by The American College of Veterinary Surgeons.

  6. Poly[ n ]catenanes: Synthesis of molecular interlocked chains

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Qiong; Rauscher, Phillip M.; Lang, Xiaolong; Wojtecki, Rudy J.; de Pablo, Juan J.; Hore, Michael J. A.; Rowan, Stuart J.

    2017-11-30

    As the macromolecular version of mechanically interlocked molecules, mechanically interlocked polymers are promising candidates for the creation of sophisticated molecular machines and smart soft materials. Poly[n]catenanes, where the molecular chains consist solely of interlocked macrocycles, contain one of the highest concentrations of topological bonds. We report, herein, a synthetic approach toward this distinctive polymer architecture in high yield (similar to 75%) via efficient ring closing of rationally designed metallosupramolecular polymers. Light-scattering, mass spectrometric, and nuclear magnetic resonance characterization of fractionated samples support assignment of the high-molar mass product (number-average molar mass similar to 21.4 kilograms per mole) to a mixture of linear poly[7-26]catenanes, branched poly[13-130]catenanes, and cyclic poly[4-7]catenanes. Increased hydrodynamic radius (in solution) and glass transition temperature (in bulk materials) were observed upon metallation with Zn2+.

  7. Design of Control and Interlocking System for a Typical Radar Transmitter

    Directory of Open Access Journals (Sweden)

    Nagabhushan Raju KONDURU

    2010-07-01

    Full Text Available The paper presents design and constructional features of CPLD based control and interlocking units for a typical MST radar transmitter. The conventional digital hardware used for controlling the radar transmitter and performing the interlock operations has been replaced by Xilinx’s XC9572C10PC84 CPLD device. The latest state of the art devices replace the front panel switches and LEDs display. This has resulted in miniaturizing the entire control and interlock subsystems. The necessary code is written in Verilog HDL. The newly designed system overcomes the design flaws in the earlier system hardware. The performance and results of the system have been verified with the simulation and real time testing at the plant. The unit testing is performed for more than four months with continuous operation of transmitter and the test report is highly encouraging.

  8. Incorporation of safety interlocks in commercial robotics for handling of nuclear materials

    International Nuclear Information System (INIS)

    Moore, F.W.

    1986-01-01

    Current robotic systems have been developed primarily for the automotive and electronic industry. The adaptation of these commercial robotic systems to applications in the manufacturing of nuclear fuel requires the addition of safety interlocks as to the handling and accountability of nuclear materials. Also, additional safety interlocks are required when the robots are operated in containment enclosures that are environmentally sealed. Interlocks have been incorporated into a commercial robot. The robotic system has been installed in the containment enclosure as part of the pellet storage subsystem into the Secure Automated Fabrication (SAF) facility currently being built by Westinghouse Hanford Company (WHC) for the US Department of Energy (DOE). The system has been installed in the Fuel Cycle Plant and is scheduled for initial operational testing in 1986

  9. Study of the Residual Strength of an RC Shear Wall with Fractal Crack Taking into Account Interlocking Interface Phenomena

    Directory of Open Access Journals (Sweden)

    O. Panagouli

    2013-01-01

    Full Text Available In the present paper, the postcracking strength of an RC shear wall element which follows the construction practices applied in Greece during the 70s is examined by taking into account the complex geometry of the crack of the wall and the mixed friction-plastification mechanisms that develop in the vicinity of the crack. Due to the significance of the crack geometry, a multiresolution analysis based on fractal geometry is performed, taking into account the size of the aggregates of concrete. The materials (steel and concrete are assumed to have elastic-plastic behaviour. For concrete, both cracking and crushing are taken into account in an accurate manner. On the interfaces of the crack, unilateral contact and friction conditions are assumed to hold. For every structure corresponding to each resolution of the interface, a classical Euclidean problem is solved. The obtained results lead to interesting conclusions concerning the influence of the simulation of the geometry of the fractal crack on the mechanical interlock between the two faces of the crack, a factor which seems to be very important to the postcracking strength of the lightly reinforced shear wall studied here.

  10. I: Hydrodynamic-focusing microreactor II: Mechanically interlocked molecules for functional materials

    Science.gov (United States)

    Coti, Karla Karina

    I: Microreactors, a class of microfluidics, offer numerous benefits -- such as small sample requirement, short analysis times and automations -- and have been used to study reactions of chemical and biological reagents. In order to understand the relationship between fast mixing, product regioselectivity, as well as the ability to separate, in time and space, the nanoparticle (NP) formation stages, a microreactor capable of fast and controllable mixing was developed (Chapter 1) based on multi-lamination and hydrodynamic-focusing. By taking advantage of the fast and controllable mixing properties of this novel microreactor one can control the time when chemical reactions commence inside the microchannels. These properties of the microreactor can be exploited to improve the product regioselectivity of a diazo-coupling reaction to attain a product distribution of monoazo to diazo product of ˜1:99, a selectivity unprecedented in both conventional, macroscopic reactors and other microfluidic systems. Additionally, the ability to separate different stages during the NP formation process inside the microreactor, allowed us to study the aggregation of polypyrrole NPs. II: Supramolecular actuators and molecular interlocked molecules, such as catenanes and rotaxanes, have attracted considerable attention because of their sophisticated topology and their application in functional molecular devices. The blending of supramolecular and mechanostereochemistry with mesoporous silica NPs has proven to be a powerful combination, leading to the development of a new class of materials -- mechanized silica nanoparticles ( Chapter 2). These new hybrid materials are designed to release their content in response to an external stimuli and their development is being driven by the need to improve current drug delivery technologies. In an effort to explore how the stimuli-controlled mechanical movement of switchable, bistable [2]rotaxanes -- based on a cyclobis(paraquat-p-phenylene) ring

  11. Online visual inspection of self-piercing riveting to determine the quality of the mechanical interlock

    International Nuclear Information System (INIS)

    Johnson, P; Cullen, J D; Al-Shamma'a, A I; Shaw, A

    2007-01-01

    Self-piercing riveting (SPR) has become a significant joining technique for the automotive applications of aluminium sheets. Quality control in this locale has progressed at an altogether more leisurely rate than other areas of mechanical joining (e.g. spotweld) and is underdeveloped. Testing the quality mechanical interlock is often achieved by destructive testing, which results in material and time wastage. The solution is online monitoring of the self-piercing riveting process to provide non-destructive testing of the mechanical interlock. Introducing sensors into the process facilitates real time data acquisition, which can be used to determine the quality of the joint

  12. The engineering project and reliability research of the safety interlock slow control system in BESIII

    International Nuclear Information System (INIS)

    Zhang Yinhong; Zhao Jingwei; Li Xiaonan; Xie Xiaoxi; Gao Cuishan; Bai Jingzhi; Chen Xihui; Min Jian; Nie Zhendong

    2008-01-01

    The new safety interlock slow control system of BESIII is designed to ensure that the BESIII interior equipments and the accelerator control center to work in coordination, and to guarantee the safety of the operating staff and all the important equipments at the same time. This paper introduces the hardware and software design of safety interlock system from the engineering requirements angle, including a detailed research on the software implementation technique of the state machine on PLC and the reliability of the system. (authors)

  13. Towards a Framework for Modelling and Verification of Relay Interlocking Systems

    DEFF Research Database (Denmark)

    Haxthausen, Anne Elisabeth

    2011-01-01

    This paper describes a framework currently under development for modelling, simulation, and verification of relay interlocking systems as used by the Danish railways. The framework is centred around a domain-specific language (DSL) for describing such systems, and provides (1) a graphical editor...

  14. 46 CFR 111.70-7 - Remote control, interlock, and indicator circuits.

    Science.gov (United States)

    2010-10-01

    ... ENGINEERING ELECTRIC SYSTEMS-GENERAL REQUIREMENTS Motor Circuits, Controllers, and Protection § 111.70-7..., interlock, or indicator circuit of a motor controller must be protected against overcurrent unless: (1) The... hazard. Note: For overcurrent protection of steering gear control and indicator circuits, see Subpart 111...

  15. Custom sectional impression trays with interlocking type handle for microstomia patients

    Directory of Open Access Journals (Sweden)

    Fernandes Aquaviva

    2009-01-01

    Full Text Available Making impressions in microstomia patients is often cumbersome. A modification of standard impression procedure is often necessary while treating such patients. This article describes the fabrication of a custom sectional impression tray with interlocking type of a handle for definitive impression procedures in a microstomia patient.

  16. Development of Interlocking Masonry Bricks and its’ Structural Behaviour: A Review Paper

    Science.gov (United States)

    Al-Fakih, Amin; Mohammed, Bashar S.; Nuruddin, Fadhil; Nikbakht, Ehsan

    2018-04-01

    Conventional bricks are the most elementary building materials for houses construction. However, the rapid growth in today’s construction industry has obliged the civil engineers in searching for a new building technique that may result in even greater economy, more efficient and durable as an alternative for the conventional brick. Moreover, the high demands for having a speedy and less labour and cost building systems is one of the factor that cause the changes of the masonry conventional systems. These changes have led to improved constructability, performance, and cost as well. Several interlocking bricks has been developed and implemented in building constructions and a number of researches had studied the manufacturing of interlocking brick and its structural behaviour as load bearing and non-load bearing element. This technical paper aims to review the development of interlocking brick and its structural behaviour. In conclusion, the concept of interlocking system has been widely used as a replacement of the conventional system where it has been utilized either as load bearing or non-load bearing masonry system.

  17. Software Verification and Validation Test Report for the HEPA filter Differential Pressure Fan Interlock System

    International Nuclear Information System (INIS)

    ERMI, A.M.

    2000-01-01

    The HEPA Filter Differential Pressure Fan Interlock System PLC ladder logic software was tested using a Software Verification and Validation (VandV) Test Plan as required by the ''Computer Software Quality Assurance Requirements''. The purpose of his document is to report on the results of the software qualification

  18. A STUDY OF THE MANAGEMENT OF OPEN FRACTURES OF TIBIA BY UNREAMED INTERLOCKING NAIL

    OpenAIRE

    Harsha Kumar

    2015-01-01

    AIMS AND OBJECTIVES : 1. To evaluate the results of closed interlocking intramedullary nailing without reaming in the treatment of open fractures of the tibial shaft. (Gustillo type 1, type 2, type 3a, type 3b) . 2. To study the difficulties ( C omplications) encountered during the operative study. 3. To mobilize the patient early. ...

  19. Control and Interlocking System for Bending Magnet Front-end at Indus-2

    Science.gov (United States)

    Kane, Sanjeev R.; Garg, Chander Kant; Nandedkar, R. V.

    2007-01-01

    We present control and interlock system developed for Indus-2 bending magnet front-end. The paper describes in detail the control of various signals associated with the front-end and the interlocking scheme implemented for the installed front-end. The number of signals associated with each front-end is ˜ 75. A control system is designed for monitoring temperature, pressure, airflow, water flow and control of vacuum gauges, fast shutter, water cooled shutter, safety shutter, pneumatic gate valves, sputter ion pump power supplies, beam position monitor etc. Two independent signals are generated for critical components that are used for software interlock and hard-wired interlock. The front-end control system is VME based and window 2000/XP workstation as an operator console. The CPU used is Motorola 68000-processor board of the VME bus having OS-9 real time operating system. One VME crate serves a cluster of 2-3 front ends. The communication between the VME and the workstation is linked over RS232 serial communication. The sputter ion power supplies are connected over isolated RS485 network. Critical protection features are implemented so that no single failure can render the system unsafe. This is implemented by providing two independent chains of protection (1) Hard wired in which relay logic is used and (2) Software. A Graphical User Interface (GUI) is developed using Lab view Version 7.0.

  20. Förster resonance energy transfer by formation of a mechanically interlocked [2]rotaxane

    NARCIS (Netherlands)

    Ogoshi, T.; Yamafuji, D.; Yamagishi, T.; Brouwer, A.M.

    2013-01-01

    A[2]rotaxane has been constructed from a di-pyrene appended pillar[5]arene wheel, a pyridinium axle, and a perylene stopper. It shows efficient Forster resonance energy transfer from pyrene to perylene by formation of a mechanically interlocked [2]rotaxane.

  1. 18 CFR 131.31 - FERC Form No. 561, Annual report of interlocking positions.

    Science.gov (United States)

    2010-04-01

    ... financial services or credit; mutual savings bank; or savings and loan association FINI Insurance company..., Annual report of interlocking positions. 131.31 Section 131.31 Conservation of Power and Water Resources... positions. (See section 46.4 of this chapter.) ER31DE98.003 INSTRUCTIONS FOR COMPLETING ANNUAL REPORT OF...

  2. Vertical interlocks of executives and performance of affiliated firms in state owned Chinese business groups

    DEFF Research Database (Denmark)

    Arnoldi, Jakob; Chen, Xin; Na, Chaohong

    increases. Our findings are consistent with the hypotheses that vertically interlocking executives can increase firm value by providing better protection against political interference and expropriation by the ultimate controllers of business groups. Our study sheds new light in the role and function...

  3. Internal Iliac Artery Embolization during an Endovascular Aneurysm Repair with Detachable Interlock Microcoils

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Woo ChuL; Jeon, Yong Sun; Hong, Kee Chun; Cho, Soon Gu; Park, Jae Young [Inha University Hospital, Inha University School of Medicine, Incheon (Korea, Republic of); Kim, Jang Yong [Dept. of Vascular and Endovascular Surgery, The Catholic University of Korea School of Medicine, Seoul (Korea, Republic of)

    2014-10-15

    The purpose of this study was to evaluate the effectiveness of detachable interlock microcoils for an embolization of the internal iliac artery during an endovascular aneurysm repair (EVAR). A retrospective review was conducted on 40 patients with aortic aneurysms, who had undergone an EVAR between January 2010 and March 2012. Among them, 16 patients were referred for embolization of the internal iliac artery for the prevention of type II endoleaks. Among 16 patients, 13 patients underwent embolization using detachable interlock microcoils during an EVAR. Computed tomographic angiographies and clinical examinations were performed during the follow-up period. Technical success, clinical outcome, and complications were reviewed. Internal iliac artery embolizations using detachable interlock microcoils were technically successful in all 13 patients, with no occurrence of procedure-related complications. Follow-up imaging was accomplished in the 13 cases. In all cases, type II endoleak was not observed with computed tomographic angiography during the median follow-up of 3 months (range, 1-27 months) and the median clinical follow-up of 12 months (range, 1-27 months). Two of 13 (15%) patients had symptoms of buttock pain, and one patient died due to underlying stomach cancer. No significant clinical symptoms such as bowel ischemia were observed. Internal iliac artery embolization during an EVAR using detachable interlock microcoils to prevent type II endoleaks appears safe and effective, although this should be further proven in a larger population.

  4. Architecture for interlock systems: reliability analysis with regard to safety and availability

    International Nuclear Information System (INIS)

    Wagner, S.; Apollonio, A.; Schmidt, R.; Zerlauth, M.; Vergara-Fernandez, A.

    2012-01-01

    For particle accelerators like LHC and other large experimental physics facilities like ITER, the machine protection relies on complex interlock systems. In the design of interlock loops for the signal exchange in machine protection systems, the choice of the hardware architecture impacts on machine safety and availability. The reliable performance of a machine stop (leaving the machine in a safe state) in case of an emergency, is an inherent requirement. The constraints in terms of machine availability on the other hand may differ from one facility to another. Spurious machine stops, lowering machine availability, may to a certain extent be tolerated in facilities where they do not cause undue equipment wear-out. In order to compare various interlock loop architectures in terms of safety and availability, the occurrence frequencies of related scenarios have been calculated in a reliability analysis, using a generic analytical model. This paper presents the results and illustrates the potential of the analysis method for supporting the choice of interlock system architectures. The results show the advantages of a 2003 (3 redundant lines with 2-out-of-3 voting) over the 6 architectures under consideration for systems with high requirements in both safety and availability

  5. Hands-on robotic distal interlocking in intramedullary nail fixation of femoral shaft fractures.

    Science.gov (United States)

    Oszwald, Markus; Westphal, Ralf; Stier, Rebecca; Gaulke, Ralph; Calafi, Afshin; Müller, Christian W; Wahl, Friedrich; Krettek, Christian; Gösling, Thomas

    2010-01-01

    Intramedullary nailing has become the gold standard in the treatment of femoral shaft fractures. This procedure involves the placement of distal interlocking bolts using the freehand technique. Accurate placement of distal interlocks can be a challenging task, especially in inexperienced hands. Misplacement of distal interlocking bolts can lead to iatrogenic fracture, instability of the bone-implant construct, or even malalignment of the extremity. Repeated drilling attempts increase radiation exposure and can cause additional bony and soft tissue trauma. We hypothesize that robot-guided placement of distal interlocks is more accurate, precise, and efficient than the freehand technique. A custom-designed drill guide was mounted onto the arm of an industrial robot. We developed a special device to secure a generic block (Synbone, Malans, Switzerland) into which an intramedullary nail could be inserted in a standardized way. A metric scale allowed later measurements of the drillings. Digital images were taken from each side of the block for analysis of the drilling trajectories. The fluoroscope was adjusted to obtain perfect circles of the distal interlocking holes. The number of images necessary to achieve this was recorded. The axis was recognized automatically by using the differences in contrast between the matrix of the generic bone and the implant (intramedullary nail). The drill trajectories were then computed. The robot with the mounted drill-guide automatically moved onto the calculated trajectory. The surgeon then executed the drilling. We performed 40 robot assisted drillings in generic blocks. Freehand drilling served as our control group. Analysis of the digital images revealed a mean deviation of 0.94 mm and 2.7° off the ideal trajectory using robotic assistance. In 100% of the cases (n = 40), the distal locking hole was hit. A mean of 8.8 images was acquired. After manual drilling, 92.5% of the distal interlocks were hit. A mean deviation of 3.66 mm

  6. Preliminary design of safety and interlock system for indian test facility of diagnostic neutral beam

    Energy Technology Data Exchange (ETDEWEB)

    Tyagi, Himanshu, E-mail: htyagi@iter-india.org [ITER-India, Institute For Plasma Research, Bhat, Gandhinagar, Gujarat (India); Soni, Jignesh [Institute For Plasma Research, Bhat, Gandhinagar, Gujarat (India); Yadav, Ratnakar; Bandyopadhyay, Mainak; Rotti, Chandramouli [ITER-India, Institute For Plasma Research, Bhat, Gandhinagar, Gujarat (India); Gahlaut, Agrajit [Institute For Plasma Research, Bhat, Gandhinagar, Gujarat (India); Joshi, Jaydeep; Parmar, Deepak [ITER-India, Institute For Plasma Research, Bhat, Gandhinagar, Gujarat (India); Bansal, Gourab; Pandya, Kaushal; Chakraborty, Arun [Institute For Plasma Research, Bhat, Gandhinagar, Gujarat (India)

    2016-11-15

    Highlights: • Indian Test Facility being built to characterize DNB for ITER delivery. • Interlock system required to safeguard the investment incurred in building the facility and protecting ITER deliverable components. • Interlock levels upto 3IL-3 identified. • Safety instrumented system for occupational safety being designed. Safety I&C functions of SIL-2 identified. • The systems are based on ITER PIS and PSS design guidelines. - Abstract: Indian Test Facility (INTF) is being built in Institute For Plasma Research to characterize Diagnostic Neutral Beam in co-operation with ITER Organization. INTF is a complex system which consists of several plant systems like beam source, gas feed, vacuum, cryogenics, high voltage power supplies, high power RF generators, mechanical systems and diagnostics systems. Out of these, several INTF components are ITER deliverable, that is, beam source, beam line components and power supplies. To ensure successful operation of INTF involving integrated operation of all the constituent plant systems a matured Data Acquisition and Control System (DACS) is required. The INTF DACS is based on CODAC platform following on PCDH (Plant Control Design Handbook) guidelines. The experimental phases involve application of HV power supplies (100 KV) and High RF power (∼800 KW) which will produce energetic beam of maximum power 6MW within the facility for longer durations. Hence the entire facility will be exposed tohigh heat fluxes and RF radiations. To ensure investment protection and to provide occupational safety for working personnel a matured Safety and Interlock system is required for INTF. The Safety and Interlock systems are high-reliability I&C systems devoted completely to the specific functions. These systems will be separate from the conventional DACS of INTF which will handle the conventional control and acquisition functions. Both, the Safety and Interlock systems are based on IEC 61511 and IEC 61508 standards as

  7. Preliminary design of safety and interlock system for indian test facility of diagnostic neutral beam

    International Nuclear Information System (INIS)

    Tyagi, Himanshu; Soni, Jignesh; Yadav, Ratnakar; Bandyopadhyay, Mainak; Rotti, Chandramouli; Gahlaut, Agrajit; Joshi, Jaydeep; Parmar, Deepak; Bansal, Gourab; Pandya, Kaushal; Chakraborty, Arun

    2016-01-01

    Highlights: • Indian Test Facility being built to characterize DNB for ITER delivery. • Interlock system required to safeguard the investment incurred in building the facility and protecting ITER deliverable components. • Interlock levels upto 3IL-3 identified. • Safety instrumented system for occupational safety being designed. Safety I&C functions of SIL-2 identified. • The systems are based on ITER PIS and PSS design guidelines. - Abstract: Indian Test Facility (INTF) is being built in Institute For Plasma Research to characterize Diagnostic Neutral Beam in co-operation with ITER Organization. INTF is a complex system which consists of several plant systems like beam source, gas feed, vacuum, cryogenics, high voltage power supplies, high power RF generators, mechanical systems and diagnostics systems. Out of these, several INTF components are ITER deliverable, that is, beam source, beam line components and power supplies. To ensure successful operation of INTF involving integrated operation of all the constituent plant systems a matured Data Acquisition and Control System (DACS) is required. The INTF DACS is based on CODAC platform following on PCDH (Plant Control Design Handbook) guidelines. The experimental phases involve application of HV power supplies (100 KV) and High RF power (∼800 KW) which will produce energetic beam of maximum power 6MW within the facility for longer durations. Hence the entire facility will be exposed tohigh heat fluxes and RF radiations. To ensure investment protection and to provide occupational safety for working personnel a matured Safety and Interlock system is required for INTF. The Safety and Interlock systems are high-reliability I&C systems devoted completely to the specific functions. These systems will be separate from the conventional DACS of INTF which will handle the conventional control and acquisition functions. Both, the Safety and Interlock systems are based on IEC 61511 and IEC 61508 standards as

  8. Case study on aggregate interlock capacity for the shear assessment of cracked reinforced-concrete bridge cross sections

    NARCIS (Netherlands)

    Lantsoght, E.O.L.; van der Veen, C.; Walraven, J.C.; de Boer, A.

    2016-01-01

    A 55-year-old bridge showed large cracking in the approach bridge caused by restraint of deformation and support settlement. After repair, it was uncertain at which crack width the traffic loads on the bridge should be further restricted. The shear capacity was calculated by counting on the

  9. Design of test JIG for centralized interlock and protection module of ITER-India Gyrotron Test Facility

    International Nuclear Information System (INIS)

    Rathod, Vipal; Rao, S.L.; Edappala, Praveenlal; Rajpal, Rachana

    2017-01-01

    Fast Interlock and protection system plays very crucial role in ensuring the safe and reliable operation of high power RF sources such as a Gyrotron system. Critical Protection Interlocks are generally implemented using hardwired components and are required to have a response time as fast as < 10 μs. In this context, an Industrial grade prototype Centralized Interlock and Protection Module (CIM) based on ITER-India design has been developed successfully with the help of local industry. This paper presents the complete requirements, approach, detailed design concept and current status of Test JIG in detail

  10. Final report on a cold climate permeable interlocking concrete pavement test facility at the University of New Hampshire Stormwater Center.

    Science.gov (United States)

    2013-05-01

    University of New Hampshire Stormwater Center (UNHSC) completed a two year field verification study of a permeable interlocking concrete pavement (PICP) stormwater management system. The purpose of this study was to evaluate the cold climate function...

  11. An overview of process instrumentation, protective safety interlocks and alarm system at the JET facilities active gas handling system

    International Nuclear Information System (INIS)

    Skinner, N.; Brennan, P.; Brown, K.; Gibbons, C.; Jones, G.; Knipe, S.; Manning, C.; Perevezentsev, A.; Stagg, R.; Thomas, R.; Yorkshades, J.

    2003-01-01

    The Joint European Torus (JET) Facilities Active Gas Handling System (AGHS) comprises ten interconnected processing sub-systems that supply, process and recover tritium from gases used in the JET Machine. Operations require a diverse range of process instrumentation to carry out a multiplicity of monitoring and control tasks and approximately 500 process variables are measured. The different types and application of process instruments are presented with specially adapted or custom-built versions highlighted. Forming part of the Safety Case for tritium operations, a dedicated hardwired interlock and alarm system provides an essential safety function. In the event of failure modes, each hardwired interlock will back-up software interlocks and shutdown areas of plant to a failsafe condition. Design of the interlock and alarm system is outlined and general methodology described. Practical experience gained during plant operations is summarised and the methods employed for routine functional testing of essential instrument systems explained

  12. The multi-interlock and check of logical system for 5 MW low power reactor automatic rod

    International Nuclear Information System (INIS)

    Li Guangjian; Zhao Zengqiao

    1992-01-01

    The safety and reliability of the logical system for 5 MW LPR automatic rod are improved, because of using multi-interlock and manual check on line. The design character and function of the logical system are introduced

  13. Accelerated pavement testing of load transfer through aggregate interlock and the influence of crack width and aggregate type - a case study

    CSIR Research Space (South Africa)

    Du Plessis, L

    2007-10-01

    Full Text Available presents the final outcome of the study in terms of theoretically based equations that were adjusted using regression techniques to fit the filed experience. These equations have now been incorporated into a mechanistically-based design method for concrete...

  14. The Effects of Interlocking a Universal Hip Cementless Stem on Implant Subsidence and Mechanical Properties of Cadaveric Canine Femora.

    Science.gov (United States)

    Buks, Yonathan; Wendelburg, Kirk L; Stover, Susan M; Garcia-Nolen, Tanya C

    2016-02-01

    To determine if an interlocking bolt would limit subsidence of the biological fixation universal hip (BFX(®)) femoral stem under cyclic loading and enhance construct stiffness, yield, and failure properties. Ex vivo biomechanical study. Cadaveric canine femora (10 pairs). Paired femora implanted with a traditional stem or an interlocking stem (constructs) were cyclically loaded at walk, trot, and gallop loads while implant and bone motions were captured using kinematic markers and high-speed video. Constructs were then loaded to failure to evaluate failure mechanical properties. Implant subsidence was greater (P = .037) for the traditional implant (4.19 mm) than the interlocking implant (0.78 mm) only after gallop cyclic loading, and cumulatively after walk, trot, and gallop cyclic loads (5.20 mm vs. 1.28 mm, P = .038). Yield and failure loads were greater (P = .029 and .002, respectively) for the interlocking stem construct (1155 N and 2337 N) than the traditional stem construct (816 N and 1405 N). Version angle change after cyclic loading was greater (P = .020) for the traditional implant (3.89 degrees) than for the interlocking implant (0.16 degrees), whereas stem varus displacement at failure was greater (P = .008) for the interlocking implant (1.5 degrees) than the traditional implant (0.17 degrees). Addition of a stabilizing bolt enhanced construct stability and limited subsidence of a BFX(®) femoral stem. Use of the interlocking implant may decrease postoperative subsidence. However, in vivo effects of the interlocking bolt on osseointegration, bone remodeling, and stress shielding are unknown. © Copyright 2016 by The American College of Veterinary Surgeons.

  15. NSTX Protection And Interlock Systems For Coil And Powers Supply Systems

    International Nuclear Information System (INIS)

    Zhao, X.; Ramakrishnan, S.; Lawson, J.; Neumeyer, C.; Marsala, R.; Schneider, H.

    2009-01-01

    NSTX at Princeton Plasma Physics Laboratory (PPPL) requires sophisticated plasma positioning control system for stable plasma operation. TF magnetic coils and PF magnetic coils provide electromagnetic fields to position and shape the plasma vertically and horizontally respectively. NSTX utilizes twenty six coil power supplies to establish and initiate electromagnetic fields through the coil system for plasma control. A power protection and interlock system is utilized to detect power system faults and protect the TF coils and PF coils against excessive electromechanical forces, overheating, and over current. Upon detecting any fault condition the power system is restricted, and it is either prevented from initializing or suppressed to de-energize coil power during pulsing. Power fault status is immediately reported to the computer system. This paper describes the design and operation of NSTX's protection and interlocking system and possible future expansion.

  16. Design lessons from using programmable controllers in the MFTF-BETA Personnel Safety and Interlocks System

    International Nuclear Information System (INIS)

    Branum, J.D.

    1983-01-01

    Applying programmable controllers in critical applications such as personnel safety and interlocks systems requires special considerations in the design of both hardware and software. All modern programmable controller systems feature extensive internal diagnostic capabilities to protect against problems such as program memory errors; however most, if not all present designs lack an intrinsic capability for detecting and countering failures on the ''field-side'' of their I/O modules. Many of the most common styles of I/O modules can also introduce potentially dangerous sneak circuits, even without component failure. This paper presents the most significant lessons learned to date in the design of the MFTF-BETA Personnel Safety and Interlocks System, which utilizes two non-redundant programmable controllers with over 800 I/O points each. Specific problems recognized during the design process as well as those discovered during initial testing and operation are discussed along with their specific solutions in hardware and software

  17. Design lessons from using programmable controllers in the MFTF-B personnel safety and interlocks system

    International Nuclear Information System (INIS)

    Branum, J.D.

    1983-01-01

    Applying programmable controllers in critical applications such as personnel safety and interlocks systems requires special considerations in the design of both hardware and software. All modern programmable controller systems feature extensive internal diagnostic capabilities to protect against problems such as program memory errors; however most, if not all present designs lack an intrinsic capability for detecting and countering failures on the field-side of their I/O modules. Many of the most common styles of I/O modules can also introduce potentially dangerous sneak circuits, even without component failure. This paper presents the most significant lessons learned to date in the design of the MFTF-B Personnel Safety and Interlocks System, which utilizes two non-redundant programmable controllers with over 800 I/O points each. Specific problems recognized during the design process as well as those discovered during initial testing and operation are discussed along with their specific solutions in hardware and software

  18. A CLINICAL STUDY OF SURGICAL MANAGEMENT OF DIAPHYSEAL FRACTURES OF TIBIA WITH INTRAMEDULLARY INTERLOCKING NAIL

    OpenAIRE

    Radhakrishna; Shivananda; Santhosh Kumar

    2014-01-01

    BACKGROUND: Intramedullary interlocking is currently considered the treatment of choice for tibial shaft fractures, with high rates of fracture union, advantage of early stabilization which decreases the morbidity and mortality rate in patients, allows early mobilization, reduces the incidence of infection, malunion, non-union or implant failure. OBJECTIVES: To assess and study diaphyseal fractures of tibia and to evaluate the functional outcome of patients with tibial shaft fracture treated ...

  19. [Proximal interlocking of humeral intramedullary nails and risk of axillary nerve injury].

    Science.gov (United States)

    Blum, J; Rommens, P M

    2002-01-01

    Possible injuries to the axillary nerve are criticised in antegrade and retrograde endomedullary nailing of the humeral shaft during proximal interlocking. Clinical experience seems not to support the theory of a high risk of nerve injury. The real risk although remains unknown under anatomical-morphological aspects. Eight complete human cadaveric shoulder-arm regions with original soft-tissue coverage had been used. Four times the unreamed humeral nail (UHN) had been inserted retrograde, and four times antegrade, distributed in each pair. Antegrade interlocking was performed after skin incision and spreading of soft tissues through the aiming devices. This involved one oblique bolt from lateral to medial. Retrograde proximal interlocking was performed under image intensifier. This involved triple interlocking, once dorso-ventrally and twice latero-medially. The incision paths have been marked. After preparation of the nerve stem in the lateral axillary portal the different branches have been searched and exposed. The spatial relations of bolts and nerve branches have been measured and the insertion path of the bolts has been revised, finally lesions of nerve structures have been documented. We found the latero-medially inserted bolt heads of the retrograde approach and the oblique bolt head of the antegrade approach being placed in a safe distance from the medio-dorsally positioned stem of the axillary nerve. On the other hand the dorsoventrally inserted bolt head (retrograde approach) showed in most cases a very tight relation to the nerve stem. Exploring the axillary nerve and its branches showed in no case a direct nerve lesion. We suggest to perform only a sharp cutaneous incision and then to prepare the muscle only by careful spreading until touching bone, with tissue retraction during drilling. In retrograde nailing the dorso-ventral bolt should only be used in extreme proximal fractures.

  20. Development of an interlocked nail for segmental defects in the rabbit tibia.

    Science.gov (United States)

    LeCronier, David J; Papakonstantinou, John S; Gheevarughese, Vineetha; Beran, Casey D; Walter, Norman E; Atkinson, Patrick J

    2012-04-01

    Previous animal models have been developed to study intramedullary nailing for challenging segmental defects in the tibia. In large animals, interlocked nail fixation created a stable environment suitable to study new bone growth technologies placed in the defect. To our knowledge, there are no comparable interlocked tibial defect models for the rabbit in which new technologies could be evaluated. Such a model would be helpful since the rabbit is a popular initial model for orthopedic research studies owing to its wide availability and low cost. While numerous studies have nailed the rabbit tibia, all were non-locked implants that allowed some degree of instability between the fracture fragments. In addition, the non-locked nails were constructed of stainless steel, whereas human nails are increasingly made from titanium alloy. In the current study, an interlocked titanium nail was developed for the rabbit tibia. It was implanted in cadaver tibiae and subjected to fatigue cycling in combined compression and bending at physiologic levels to 21,061 cycles. This duration is estimated to represent 12 weeks of gait by the animal. Before and after fatigue cycling, monotonic testing was performed in compression and bending at physiologic levels. The intact contralateral limbs served as controls. All limbs completed the cycling; the instrumented limbs exhibited interfragmentary cyclic strain amplitudes during fatigue (616 +/- 139 micro-strain), which was significantly greater than the control limbs (136 +/- 35 microstrain). Monotonic strain amplitudes for the test limbs in bending and compression were 4839 +/- 1028 and 542 +/- 122 microstrain, respectively; corresponding values for the control bones were 407 +/- 118 and 95 +/- 38 microstrain, respectively. These data are similar to those presented in prior studies in larger bone models. The current study presents one method for interlocked nail fixation for this complex tibial shaft fracture in a small animal.

  1. Radiation-free Insertion of Distal Interlocking Screw in Tibial and Femur Nailing: A Simple Technique.

    Science.gov (United States)

    Soni, Ritesh Kumar; Mehta, Surender Mohan; Awasthi, Bhanu; Singh, Janith Lal; Kumar, Amit; Thakur, Lokesh; Tripathy, Sujit Kumar

    2012-01-01

    Distal interlocking screw insertion in intramedullary nailing of long-bone fracture is a challenging task for orthopedic surgeons. It is difficult particularly when the surgeon is in his learning stage or when image intensifier is not available. We describe a radiation-free technique of distal interlocking screw insertion which is easy and practicable. In this technique, a same length nail is placed over the skin (outer nail) and through its distal-most screw hole, a 3.2 mm drill bit is inserted to drill the distal locking screw hole of the intramedullary nail (inner nail). With a small skin incision over the distal screw holes, the distal-most screw hole is identified; the bone window overlying the screw hole is widened with an awl and a locking bolt is inserted with a washer under direct visualization. The other distal interlocking screw is simply drilled by matching the other three holes of the outer and inner nails. We have operated 86 patients (39 femoral shaft fracture and 47 tibial shaft fracture) in 1 year where this technique was used. There were 41 open fracture and 45 closed fracture. Within 6 months of follow-up, bony union was achieved in 36 of 39 femur fractures and 45 of 47 tibial fractures. No unwanted complications were observed during the postoperative period and in follow-up. This method of radiation-free distal interlocking screw insertion is simple and can be used in third world country where image intensifier facility is not available. However, surgeons are encouraged to use image intensifier facility where the facility is available.

  2. Economic aspects of interlocking hollow brick system designed for industrialized building system

    Science.gov (United States)

    Tahir, Mahmood Md.; Saggaff, Anis; Ngian, Shek Poi; Sulaiman, Arizu

    2017-11-01

    Construction industry has moved forward into a technology driven where a transition is in progress from conventional method to a more advanced and mechanised system known as the Industrialised Building System (IBS). However, the need to implement the IBS should be well understood by all construction players such as designer, architect, contraction, erectors and construction workers. Therefore, there is a need to educate all these construction players which should be spearheaded by authorities such as Construction Industrial Development Board where enforcement trough building by laws as well as initiative to those that adopt the IBS in their construction. This paper reports on economic aspects of using interlocking hollow brick system in construction as an alternative method offered for Industrialized Building System. The main objective is to address the economic aspects of using interlocking block system in terms of time, costs, and utilization of manpower and to present some of the experimental tests results related to Interlocking Hollow Brick System (IHBS). Example of savings from the use of IHBS is presented in this paper by comparing the construction of two storey terrace house with build-up area of about 200 square meter with conventional construction method of typical reinforced concrete construction (RCC) compared to IHBS. The comparison shows that the implementation of IHBS can reduce construction time, cost, and utilization of man power up to 26.6% compared to the conventional method. Moreover, the construction time using IHBS can also be reduced by up to 50% as compared to the conventional construction.

  3. A STUDY OF THE MANAGEMENT OF OPEN FRACTURES OF TIBIA BY UNREAMED INTERLOCKING NAIL

    Directory of Open Access Journals (Sweden)

    Kuppa Srinivas

    2015-01-01

    Full Text Available AIMS AND OBJECTIVES: To evaluate the results of closed interlocking intramedullary nailing without reaming in the treatment of open fractures of t he tibial shaft and study the difficulties (complications encountered during the operative study. To compare the efficacy of interlocking intramedullary nailing without reaming in treating open fractures of tibia, Time required for the union of fracture, Range of motion of ankle and knee joint, Rate of malunion and mal rotation and Pain at the knee joint. RESULTS: The average age of patient is 32 years,83.33% are males, road traffic accidents account for majority(79.16%,right side involved in 58.33%,gustillo type II and type I compound fractures are common, full range of movements is seen in 66.67% by 12 weeks and union occurred in 95.83% by 9 months. Thirteen (54.17% patients had excellent results, six (25% patients had good results, four (1 6.67% patients had fair results and one (4.16 patient had poor result. CONCLUSION: Unreamed interlocking intramedullary nailing with the help of image intensifier seems feasible in open diaphyseal fractures of tibia with the advantages of minimal blood l oss, low risk of infection, early mobilisation , earlier soft tissue coverage , Promotes early union , minimal hospital stay and early returns to activities

  4. Automatic generation and verification of railway interlocking control tables using FSM and NuSMV

    Directory of Open Access Journals (Sweden)

    Mohammad B. YAZDI

    2009-01-01

    Full Text Available Due to their important role in providing safe conditions for train movements, railway interlocking systems are considered as safety critical systems. The reliability, safety and integrity of these systems, relies on reliability and integrity of all stages in their lifecycle including the design, verification, manufacture, test, operation and maintenance.In this paper, the Automatic generation and verification of interlocking control tables, as one of the most important stages in the interlocking design process has been focused on, by the safety critical research group in the School of Railway Engineering, SRE. Three different subsystems including a graphical signalling layout planner, a Control table generator and a Control table verifier, have been introduced. Using NuSMV model checker, the control table verifier analyses the contents of control table besides the safe train movement conditions and checks for any conflicting settings in the table. This includes settings for conflicting routes, signals, points and also settings for route isolation and single and multiple overlap situations. The latest two settings, as route isolation and multiple overlap situations are from new outcomes of the work comparing to works represented on the subject recently.

  5. Reviewed approach to defining the Active Interlock Envelope for Front End ray tracing

    Energy Technology Data Exchange (ETDEWEB)

    Seletskiy, S. [Brookhaven National Lab. (BNL), Upton, NY (United States); Shaftan, T. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-09-24

    To protect the NSLS-II Storage Ring (SR) components from damage from synchrotron radiation produced by insertion devices (IDs) the Active Interlock (AI) keeps electron beam within some safe envelope (a.k.a Active Interlock Envelope or AIE) in the transverse phase space. The beamline Front Ends (FEs) are designed under assumption that above certain beam current (typically 2 mA) the ID synchrotron radiation (IDSR) fan is produced by the interlocked e-beam. These assumptions also define how the ray tracing for FE is done. To simplify the FE ray tracing for typical uncanted ID it was decided to provide the Mechanical Engineering group with a single set of numbers (x,x’,y,y’) for the AIE at the center of the long (or short) ID straight section. Such unified approach to the design of the beamline Front Ends will accelerate the design process and save valuable human resources. In this paper we describe our new approach to defining the AI envelope and provide the resulting numbers required for design of the typical Front End.

  6. Outcomes in closed reamed interlocking nail in fractures of shaft of femur

    International Nuclear Information System (INIS)

    Mohammad, T.; Sawati, A.; Ahmed, A.

    2015-01-01

    Femoral shaft fracture is one of the common fractures seen in accident and emergency department of our hospital. Violent forces are required to break this and strongest of human bones. There are various treatment modalities for femoral shaft fractures in adults like traction, brace, platting, intramedullary nail (IMN), external fixators and inter locking nails. The study was done with an objective to evaluate the results of closed reamed interlocking nail in fractures of shaft of femur. Methods: A prospective study of 114 cases of femoral shaft fractures was carried out at orthopaedic unit of Ayub Teaching Hospital Abbottabad during 1 year. All these cases were treated with statically locked nails under spinal or general anaesthesia. These cases were followed up for up to one year and Results of the interlocking nail were observed in terms of union and complications. Results: Out of 114 patients, 95 underwent union in 90-150 days with a mean of 110.68 days. Ten patients had dynamization within six weeks because of obvious fracture gap in radiograph. There were 3 patients who had non-union, and 6 patients had delayed union which was treated with dynamization. Conclusion: Close reamed interlocking intramedullary nail in femoral shaft fractures is the treatment of choice. Patient rehabilitation is early, hospitalization is short, and fracture healing response is good. (author)

  7. Extending DIII-D Neutral Beam Modulated Operations with a Camac Based Total on Time Interlock

    International Nuclear Information System (INIS)

    Baggest, D.S.; Broesch, J.D.; Phillips, J.C.

    1999-01-01

    A new total-on-time interlock has increased the operational time limits of the Neutral Beam systems at DIII-D. The interlock, called the Neutral Beam On-Time-Limiter (NBOTL), is a custom built CAMAC module utilizing a Xilinx 9572 Complex Programmable Logic Device (CPLD) as its primary circuit. The Neutral Beam Injection Systems are the primary source of auxiliary heating for DIII-D plasma discharges and contain eight sources capable of delivering 20MW of power. The delivered power is typically limited to 3.5 s per source to protect beam-line components, while a DIII-D plasma discharge usually exceeds 5 s. Implemented as a hardware interlock within the neutral beam power supplies, the NBOTL limits the beam injection time. With a continuing emphasis on modulated beam injections, the NBOTL guards against command faults and allows the beam injection to be safely spread over a longer plasma discharge time. The NBOTL design is an example of incorporating modern circuit design techniques (CPLD) within an established format (CAMAC). The CPLD is the heart of the NBOTL and contains 90% of the circuitry, including a loadable, 1 MHz, 28 bit, BCD count down timer, buffers, and CAMAC communication circuitry. This paper discusses the circuit design and implementation. Of particular interest is the melding of flexible modern programmable logic devices with the CAMAC format

  8. OUTCOMES IN CLOSED REAMED INTERLOCKING NAIL IN FRACTURES OF SHAFT OF FEMUR.

    Science.gov (United States)

    Mohammad, Taj; Khan, Alamzeb; Sawati, Alamzeb; Ahmed, Ashfaq; Awan, Abdus Saboor; Saboor, Abdus; Siddique

    2015-01-01

    Femoral shaft fracture is one of the common fractures seen in accident and emergency department of our hospital. Violent forces are required to break this and strongest of human bones. There are various treatment modalities for femoral shaft fractures in adults like traction, brace, platting, intramedullary nail (IMN), external fixators and inter locking nails. The study was done with an objective to evaluate the results of closed reamed interlocking nail in fractures of shaft of femur. A prospective study of 114 cases of femoral shaft fractures was carried out at orthopaedic unit of Ayub Teaching Hospital Abbottabad during 1 year. All these cases were treated with statically locked nails under spinal or general anaesthesia. These cases were followed up for up to one year and Results of the interlocking nail were observed in terms of union and complications. Out of 114 patients, 95 underwent union in 90-150 days with a mean of 110.68 days. Ten patients had dynamization within six weeks because of obvious fracture gap in radiograph. There were 3 patients who had non-union, and 6 patients had delayed union which was treated with dynamization. Close reamed interlocking intramedullary nail in femoral shaft fractures is the treatment of choice. Patient rehabilitation is early, hospitalization is short, and fracture healing response is good.

  9. Comparison of non-compression and compression interlocking intramedullary nailing in rabbit femoral shaft osteotomy model.

    Science.gov (United States)

    Baki, Mehmet Emre; Aldemir, Cengiz; Duygun, Fatih; Doğan, Ali; Kerimoğlu, Gökçen

    2017-04-01

    This study aims to compare non-compression and compression intramedullary nailing in an experimental femoral shaft osteotomy model in terms of radiological, histological, and biomechanical aspects. Twenty-four white New Zealand rabbits (average weight 4.3 kg; range 4 to 4.8 kg) were divided into three groups. A right femoral osteotomy was performed in all rabbits and all femurs were fixed with titanium compression interlocking intramedullary nail. After locking of nails, no compression was performed in group 1 while 0.5 mm and 1 mm compressions were performed in group 2 and 3, respectively. All rabbits were sacrificed four weeks after operation. Fracture sites were examined histologically and radiologically. Finite element analyses were performed. Radiological scores of groups 2 and 3 were significantly higher than group 1. There was no significant difference between groups 2 and 3 radiologically. Best histological scores were achieved in group 2. According to finite element analyses, osteotomy site in group 2 was exposed to 1240 N of load and 34.5 MPa of mean stress. Compression interlocking intramedullary nailing provides faster fracture healing than non-compression interlocking intramedullary nailing. Best histological fracture healing scores were obtained with 0.5 mm compression performed at the fracture site.

  10. Bio-inspired design of geometrically interlocked 3D printed joints

    Science.gov (United States)

    Kumar, S.; Oliva, Noel; Kumar's Lab Team

    The morphology of the adhesive-adherend interface significantly affects the mechanical behavior of adhesive joints. As seen in some biocomposites like human skull, or the nacre of some bivalve molluscs' shells, a geometrically interlocking architecture of interfaces creates toughening and strengthening mechanisms enhancing the mechanical properties of the joint. In an attempt to characterize this mechanical interlocking mechanism, this study is focused on computational and experimental investigation of a single-lap joint with a very simple geometrically interlocked interface design in which both adherends have a square waveform configuration of the joining surfaces. This square waveform configuration contains a positive and a negative rectangular teeth per cycle in such a way that the joint is symmetric about the mid-bondlength. Both physical tests performed on 3D printed prototypes of joints and computational results indicate that the joints with square waveform design have higher strength and damage tolerance than those of joints with flat interface. In order to identify an optimal design configuration of this interface, a systematic parametric study is conducted by varying the geometric and material properties of the non-flat interface. This work was supported by Lockheed Martin (Award No: 12NZZ1).

  11. Global Comparison Aggregation Services

    OpenAIRE

    Zhu, Hongwei; Madnick, Stuart; Siegel, Michael

    2003-01-01

    Web aggregation has been available regionally for several years, but this service has not been offered globally. As an example, using multiple regional comparison aggregators, we analyze the global prices for a Sony camcorder, which differ by more than three times. We further explain that lack of global comparison aggregation services partially contribute to such huge price dispersion. We also discuss difficulties encountered in the manual integration of global web sources. Motivated by this ...

  12. Reinforcing the role of the conventional C-arm - a novel method for simplified distal interlocking

    Directory of Open Access Journals (Sweden)

    Windolf Markus

    2012-01-01

    Full Text Available Abstract Background The common practice for insertion of distal locking screws of intramedullary nails is a freehand technique under fluoroscopic control. The process is technically demanding, time-consuming and afflicted to considerable radiation exposure of the patient and the surgical personnel. A new concept is introduced utilizing information from within conventional radiographic images to help accurately guide the surgeon to place the interlocking bolt into the interlocking hole. The newly developed technique was compared to conventional freehand in an operating room (OR like setting on human cadaveric lower legs in terms of operating time and radiation exposure. Methods The proposed concept (guided freehand, generally based on the freehand gold standard, additionally guides the surgeon by means of visible landmarks projected into the C-arm image. A computer program plans the correct drilling trajectory by processing the lens-shaped hole projections of the interlocking holes from a single image. Holes can be drilled by visually aligning the drill to the planned trajectory. Besides a conventional C-arm, no additional tracking or navigation equipment is required. Ten fresh frozen human below-knee specimens were instrumented with an Expert Tibial Nail (Synthes GmbH, Switzerland. The implants were distally locked by performing the newly proposed technique as well as the conventional freehand technique on each specimen. An orthopedic resident surgeon inserted four distal screws per procedure. Operating time, number of images and radiation time were recorded and statistically compared between interlocking techniques using non-parametric tests. Results A 58% reduction in number of taken images per screw was found for the guided freehand technique (7.4 ± 3.4 (mean ± SD compared to the freehand technique (17.6 ± 10.3 (p p = 0.001. Operating time per screw (from first shot to screw tightened was on average 22% reduced by guided freehand (p = 0

  13. Interlocking Directorships in Polish Joint Stock Companies = Medsebojna prepletenost članov nadzornih svetov v delniških družbah na Poljskem

    OpenAIRE

    Marek Pawlak

    2008-01-01

    Studies concerning interlocking directorships have been carried out among Polish joint stock corporations. The main source of data have been the announcements that are to be published by corporations regularly in a journal called Business and Court Gazette (BCG). Interlocking directorships constitute a network among corporations the use of which enables co-ordinated management of the whole group. The phenomenon of interlocking directorships in Polish joint stock companies can be compared to t...

  14. Platelet activation and aggregation

    DEFF Research Database (Denmark)

    Jensen, Maria Sander; Larsen, O H; Christiansen, Kirsten

    2013-01-01

    This study introduces a new laboratory model of whole blood platelet aggregation stimulated by endogenously generated thrombin, and explores this aspect in haemophilia A in which impaired thrombin generation is a major hallmark. The method was established to measure platelet aggregation initiated...

  15. Aggregates from mineral wastes

    Directory of Open Access Journals (Sweden)

    Baic Ireneusz

    2016-01-01

    Full Text Available The problem concerning the growing demand for natural aggregates and the need to limit costs, including transportation from remote deposits, cause the increase in growth of interest in aggregates from mineral wastes as well as in technologies of their production and recovery. The paper presents the issue related to the group of aggregates other than natural. A common name is proposed for such material: “alternative aggregates”. The name seems to be fully justified due to adequacy of this term because of this raw materials origin and role, in comparison to the meaning of natural aggregates based on gravel and sand as well as crushed stones. The paper presents characteristics of the market and basic application of aggregates produced from mineral wastes, generated in the mining, power and metallurgical industries as well as material from demolished objects.

  16. Incidence of Varus Malalignment Post Interlocking Nail in Proximal Femur Shaft Fractures Comparing Two Types of Entry Points.

    Science.gov (United States)

    Sadagatullah, A N; Nazeeb, M N; Ibrahim, S

    2017-11-01

    Introduction: Osteosynthesis of the femur using an interlocking nail is the gold standard for treating diaphyseal fractures of the femur. There are two established entry points for the antegrade interlocking nails which is the piriformis fossa or the greater trochanter. It has been reported that varus malalignment was frequently seen in proximal femur fracture which were treated with interlocking nail utilizing the greater trochanter entry point. The study was done to find out if the problem was of significance. Materials and Methods: This was a retrospective study which included 179 patients with femur fractures which were treated from January 2013 till September 2015 in one Hospital. They were treated with interlocking nail either by utilizing the piriformis fossa (PF) or the greater trochanter (GT) entry points. Post-operative radiographs of the femur were used to measure the varus deformity. Results: Out of 179 patients, there were 5 patients who were reported to have unacceptable varus malalignment (2.79%). These 5 patients were out of the 88 (5.68%) patients utilizing the greater trochanter as the entry point. The same 5 patients were out 90 patients that were diagnosed with proximal femur shaft fractures (5.55%). Analysis with logistic regression was statistically not significant. Conclusion: There was higher rate of varus malalignment seen in proximal femur shaft fractures treated with interlocking nails utilizing the greater trochanter entry point. The incidence of varus malalignment was not significant statistically.

  17. A comparative study of interlocking directorates at the end of the import-substituting industrialization period in Argentina and Chile

    Directory of Open Access Journals (Sweden)

    Erica Salvaj, Andrea Lluch

    2012-12-01

    Full Text Available Research on interlocking directorates has been conducted primarily in the United States and European countries. Little work of either theoretical or empirical nature has been done to study the characteristics and the factors that affect this important business network in peripheral and turbulent economies. In this comparative and historical study, we focus on the effect of the political and economic turbulence and the ownership composition of the largest firms on shaping the structure of interlocking directorates in Argentina and Chile by the end of the sixties. Four main findings result from this analysis: 1 the interlocking directorate in Argentina is more fragmented than in Chile; 2 most relevant actors in the directorship interlock in Argentina are firms in industries considered strategic by the government; 3 multinational subsidiaries occupy a central position in Argentina; 4 banks and firms owned by local business groups played a central role in the interlocking directorates in Chile. This study shows how the institutional and economic factors shape the structure of relations between companies.

  18. Comparative study between reamed versus unreamed interlocking intramedullary nailing in compound fractures of shaft tibia

    Directory of Open Access Journals (Sweden)

    Subhash Puri

    2013-01-01

    Full Text Available Background: Tibia is the commonest bones to sustain open injury because of subcutaneous position. Treatment of open fractures requires simultaneous management of both skeletal and soft tissue injury. Intramedullary nailing with reaming is generally considered to be contraindicated for open fractures tibia, because it damages the endosteal blood supply which will lead to non-union, deep infection. However, recent studies with or without reaming in open fracture tibia shows no influence in healing of fracture. Purpose: To compare the clinical and radiological results of intramedullary interlocking nailing of open fractures of the tibial shaft after reaming versus unreamed medullary canal. Materials and Methods: Between 2008 and 2011, we have treated 40 patients with compound tibia fracture (type I, II, IIIA by simultaneous care of wound and skeletal injury. Primary fixation for fracture stabilization was done by closed intramedullary interlock nailing either reamed or unreamed; the allocation to the two groups made on alternating basis. Wound was managed by thorough debridement with primary/delayed primary closure by suturing, split thickness skin grafting or fasciocutaneous flap cover. Active, non-weight bearing exercises were started from next post-op day. Partial weight bearing after suture removal was started on 12 th day. Further follow-up was done at 6 weeks interval for union. Results: Open fractures of shaft of tibia treated with unreamed/reamed interlocking nailing gave excellent results. In present series, 19 fractures (95% treated by unreamed and 19 (95% fractures treated by reamed technique, united within 6 months of injury. Delay in union was noticed in one patient treated by unreamed technique who had segmental and extensive soft tissue injury and in reamed nailing there was one patient with deep infection, which was treated with antibiotic coated nail. Conclusion: Time to complete union was similar in both groups. Adequate

  19. Intramedullary nailing without interlocking screws for femoral and tibial shaft fractures.

    Science.gov (United States)

    Kreb, Dieuwertje L; Blokhuis, Taco J; van Wessem, Karlijn J P; Bemelman, Mike; Lansink, Koen W W; Leenen, Luke P H

    2013-08-01

    Intramedullary fixation is the treatment of choice for diaphyseal fractures of the femur and tibia. Locking the implant can sometimes be cumbersome and time consuming. In our institution, fractures with axial and rotational stability are treated with intramedullary nailing without interlocking. All consecutive patients presented in the University Medical Center Utrecht from October 2003 to August 2009 with acute traumatic diaphyseal fractures of the tibia or femur that were considered axial and rotational stable were included. They underwent internal fixation using intramedullary nails without interlocking. Patient records were evaluated for duration of surgery, perioperative complications, consolidation time and re-operations. Twenty-nine long bone fractures were treated in 27 patients: 20 men and 7 women, with an average age of 28.9 years (range 15.6-54.4). There were 12 femoral fractures and 17 tibial fractures. Sixteen fractures were closed and 13 were open (10 Gustilo 1, 3 Gustilo 2). The mean operating time was 43 min (range 18-68 min) for tibial fractures and 55 min (range 47-150 min) for femoral fractures. Postoperative complications occurred in six patients. Two patients (three fractures) were lost to follow-up. Healing occurred in 25 of the 26 remaining fractures (96 %) without additional interventions. One tibia was secondarily converted to a standard locked nail because of axial and rotational instability. All patients returned to their pre-injury level of activity. The use of intramedullary nailing without interlocking is associated with minimal complications in selected fractures. The advantages include a short operating time and the simplicity of its application.

  20. Aggregated Computational Toxicology Online Resource

    Data.gov (United States)

    U.S. Environmental Protection Agency — Aggregated Computational Toxicology Online Resource (AcTOR) is EPA's online aggregator of all the public sources of chemical toxicity data. ACToR aggregates data...

  1. Testing the permeability and corrosion resistance of micro-mechanically interlocked joints

    DEFF Research Database (Denmark)

    Byskov-Nielsen, Jeppe; Holm, Allan Hjarbæk; Højsholt, Rune

    2011-01-01

    Micro-mechanical interlocking (MMI) can be applied to create new and interesting composite materials. We have employed laser structuring to achieve MMI between stainless steel and plastic with extremely high joint strength. However, the water permeability and corrosion resistance of the joint must...... be taken in order not to degrade the corrosion resistance of the sample to an unacceptable level....... is conducted. The permeability seems to be consistent with the Hagen–Poiseuille equation independent of the laser structuring technique and is orders of magnitudes larger than the diffusion rate through the plastic. Two different types of corrosion tests have been undertaken, and we show that care must...

  2. Facile route to an all-organic, triply threaded, interlocked structure by templated dynamic clipping.

    Science.gov (United States)

    Pun, Andrew; Hanifi, David A; Kiel, Gavin; O'Brien, Evan; Liu, Yi

    2012-12-21

    Encaged! Three-terminal interlocked molecular species were obtained by dynamic (2+3) assembly of a cagelike macro-bicycle around a trifurcated trispyridinium π guest. The complex is stabilized by π-π interactions and multiple [C-H⋅⋅⋅O] and [C-H⋅⋅⋅N] interactions. Uncomplexed guest molecules cocrystallize alongside the threaded complexes in the solid state, thus giving extended π-stacked columns. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  3. Ground-state kinetics of bistable redox-active donor-acceptor mechanically interlocked molecules.

    Science.gov (United States)

    Fahrenbach, Albert C; Bruns, Carson J; Li, Hao; Trabolsi, Ali; Coskun, Ali; Stoddart, J Fraser

    2014-02-18

    The ability to design and confer control over the kinetics of theprocesses involved in the mechanisms of artificial molecular machines is at the heart of the challenge to create ones that can carry out useful work on their environment, just as Nature is wont to do. As one of the more promising forerunners of prototypical artificial molecular machines, chemists have developed bistable redox-active donor-acceptor mechanically interlocked molecules (MIMs) over the past couple of decades. These bistable MIMs generally come in the form of [2]rotaxanes, molecular compounds that constitute a ring mechanically interlocked around a dumbbell-shaped component, or [2]catenanes, which are composed of two mechanically interlocked rings. As a result of their interlocked nature, bistable MIMs possess the inherent propensity to express controllable intramolecular, large-amplitude, and reversible motions in response to redox stimuli. In this Account, we rationalize the kinetic behavior in the ground state for a large assortment of these types of bistable MIMs, including both rotaxanes and catenanes. These structures have proven useful in a variety of applications ranging from drug delivery to molecular electronic devices. These bistable donor-acceptor MIMs can switch between two different isomeric states. The favored isomer, known as the ground-state co-conformation (GSCC) is in equilibrium with the less favored metastable state co-conformation (MSCC). The forward (kf) and backward (kb) rate constants associated with this ground-state equilibrium are intimately connected to each other through the ground-state distribution constant, KGS. Knowing the rate constants that govern the kinetics and bring about the equilibration between the MSCC and GSCC, allows researchers to understand the operation of these bistable MIMs in a device setting and apply them toward the construction of artificial molecular machines. The three biggest influences on the ground-state rate constants arise from

  4. Buying intoformalization? State institutions and interlocked markets in African small-scale gold mining

    DEFF Research Database (Denmark)

    Fold, Niels; Jønsson, Jesper Bosse; Yankson, Paul

    2014-01-01

    During recent decades, artisanal and small-scale mining (ASM) in Africa has increased tremendously. An unknown but significant part is constituted by activities that are not based on legally registered mining licenses. The division of formal and informal ASM is, however, dissolved in the marketing....... This paper argues that future research and design of policy mechanisms needs to focus on the inter-linkages of actors and material flows within the complex intertwinement of the formal and informal ASM sectors. Our point of departure is the findings on interlocked markets within the literature on rural...

  5. The Use of UML to Development of a Railway Interlocking System

    Directory of Open Access Journals (Sweden)

    Karol Rastocny

    2003-01-01

    Full Text Available The paper deals with problems of using the Unifield Modeling Lanfuage (UML in developmentt of new railway interlocking and signalling systems. A simplifield example of the control circuit of a point machine is used to demonstrate an object-oriented approach to specifying the functional safety requirements. An informal specification given by the relevant technical standart is used as a starting point and results in semi-formal specification based on UML model. Advantages of the presented approach are discussed and new trends of increasing formality of UML models are indicated within conclusions.

  6. Successful Transcatheter Embolization of Penetrating Aortic Ulcer Using Interlocking Detachable Coils

    International Nuclear Information System (INIS)

    Hama, Yukihiro; Kaji, Tatsumi; Iwasaki, Yoshie; Hinokiyama, Kazuhiro; Shimizu, Masafumi; Kusano, Shoichi

    2000-01-01

    A 54-year-old man with persistent chest pain was hospitalized for hypertension and DeBakey type IIIb aortic dissection. The false lumen of the dissection was almost completely thrombosed; however, a penetrating atherosclerotic ulcer (PAU) was observed 5 weeks later. At that time, we successfully embolized the PAU with a microcatheter and interlocking detachable coils (IDCs). The patient is well with no episodes of relapse in 20 months of follow-up. This case suggests the utility of the microcatheter and IDC system as an alternative to surgery

  7. Recycled aggregates concrete: aggregate and mix properties

    Directory of Open Access Journals (Sweden)

    González-Fonteboa, B.

    2005-09-01

    Full Text Available This study of structural concrete made with recycled concrete aggregate focuses on two issues: 1. The characterization of such aggregate on the Spanish market. This involved conducting standard tests to determine density, water absorption, grading, shape, flakiness and hardness. The results obtained show that, despite the considerable differences with respect to density and water absorption between these and natural aggregates, on the whole recycled aggregate is apt for use in concrete production. 2. Testing to determine the values of basic concrete properties: mix design parameters were established for structural concrete in non-aggressive environments. These parameters were used to produce conventional concrete, and then adjusted to manufacture recycled concrete aggregate (RCA concrete, in which 50% of the coarse aggregate was replaced by the recycled material. Tests were conducted to determine the physical (density of the fresh and hardened material, water absorption and mechanical (compressive strength, splitting tensile strength and modulus of elasticity properties. The results showed that, from the standpoint of its physical and mechanical properties, concrete in which RCA accounted for 50% of the coarse aggregate compared favourably to conventional concrete.

    Se aborda el estudio de hormigones estructurales fabricados con áridos reciclados procedentes de hormigón, incidiéndose en dos aspectos: 1. Caracterización de tales áridos, procedentes del mercado español. Para ello se llevan a cabo ensayos de densidad, absorción, granulometría, coeficiente de forma, índice de lajas y dureza. Los resultados obtenidos han puesto de manifiesto que, a pesar de que existen diferencias notables (sobre todo en cuanto a densidad y absorción con los áridos naturales, las características de los áridos hacen posible la fabricación de hormigones. 2. Ensayos sobre propiedades básicas de los hormigones: se establecen parámetros de dosificaci

  8. Protein Colloidal Aggregation Project

    Science.gov (United States)

    Oliva-Buisson, Yvette J. (Compiler)

    2014-01-01

    To investigate the pathways and kinetics of protein aggregation to allow accurate predictive modeling of the process and evaluation of potential inhibitors to prevalent diseases including cataract formation, chronic traumatic encephalopathy, Alzheimer's Disease, Parkinson's Disease and others.

  9. The Layer of Kevlar Angle-interlock Woven Fabric Effect on the Tensile Properties of Composite Materials

    Science.gov (United States)

    Xie, Wan-Chen; Guo, Xu-Yi; Yan, Tao; Zhang, Shang-Yong

    2017-09-01

    This article is based on the structure of three-dimensional angle-interlock longitudinal.The 3-layer, 5-layer, 7-layer and 9-layer of angle-interlock 3D fabrics are woven on sample weaving machine respectively with the 1500D Kevlar fiber twist filament produced by United States DuPont. At the same time, Kevlar plain weave fabric is woven, and three, five, seven and nine layers’ fabric are to be compared. In the process of VARTM composite technology, epoxy resin is matrix material, acetone is diluent, triethylene tetramine is curing agent and the five different fabrics are the reinforced materials respectively. Finally, eight different three-dimensional woven fabric composites were prepared. In this paper, the tensile properties of eight kinds of three-dimensional woven fabric composites were tested respectively.Finally, it is concluded that the five-layer angle-interlock woven fabric prepared by Kevlar fiber shows the best tensile property.

  10. Control interlock and monitoring system for 80 KW IOT based RF power amplifier system at 505.812 MHz for Indus-2

    International Nuclear Information System (INIS)

    Kumar, Gautam; Deo, R.K.; Jain, M.K.; Bagre, Sunil; Hannurkar, P.R.

    2013-01-01

    For 80 kW inductive output tube (IOT) based RF power amplifier system at 505.812 MHz for Indus-2, a control, interlock and monitoring system is realized. This is to facilitate proper start-up and shutdown of the amplifier system, monitor various parameters to detect any malfunction during its operation and to bring the system in a safe stage, thereby assuring reliable operation of the amplifier system. This high power amplifier system incorporates interlocks such as cooling interlocks, various voltage and current interlocks and time critical RF interlocks. Processing of operation sequence, cooling interlocks and various voltage and current interlocks have been realized by using Siemens make S7-CPU-315-2DP (CPU) based programmable logic controller (PLC) system. While time critical or fast interlocks have been realized by using Siemens make FPGA based Boolean Co-processor FM-352-5 which operates in standalone mode. Siemens make operating panel OP277 6'' is being used as a human machine interface (HMI) device for command, data, alarm generation and process parameter monitoring. (author)

  11. Changes in microgaps, micromotion, and trabecular strain from interlocked cement-trabecular bone interfaces in total knee replacements with in vivo service

    NARCIS (Netherlands)

    Miller, M.A.; Goodheart, J.R.; Khechen, B.; Janssen, D.W.; Mann, K.A.

    2016-01-01

    The initial fixation of cemented Total Knee Replacements (TKRs) relies on mechanical interlock between cement and bone, but loss of interlock occurs with in vivo service. In this study, cement-trabeculae gap morphology and micromechanics were measured for lab prepared (representing post-operative

  12. Successful commissioning of an electronic interlocking system, taking the example of Plochingen; Erfolgreiche Inbetriebnahme eines elektronischen Stellwerks - Beispiel ESTW Plochingen

    Energy Technology Data Exchange (ETDEWEB)

    Woerner, C.; Rosenberger, H. [DB ProjektBau GmbH, Stuttgart (Germany); Kuehnle, T. [THOST Projektmanagement GmbH, Pforzheim (Germany)

    2007-03-15

    It was essential to draw up a precise commissioning concept for the new electronic interlocking system in Plochingen, given the scale of the measure and the high frequency of trains passing through. The authors describe the detailed documents that were compiled to begin with, dealing, in particular, with technical and operational feasibility and time requirements. Such an input was a precondition for the commissioning operation to be completed smoothly. Thanks to this concept and the committed work of all those involved at first hand, commissioning the new electronic interlocking system in Plochingen was completed within the five night-time line closures planned for it between 13 and 18 April 2006. (orig.)

  13. Periareolar augmentation mastopexy with interlocking gore-tex suture, retrospective review of 50 consecutive patients.

    Science.gov (United States)

    Franco, Johnny; Kelly, Emma; Kelly, Michael

    2014-11-01

    Periareolar Augmentation Mastopexy is one of the most challenging operations in plastic surgery. Problems with scar quality, areolar widening, and distortion are frequent problems that interfere with a predictable result. A retrospective review was performed on fifty consecutive patients who underwent a periareolar augmentation mastopexy with the interlocking approach. Of the 50 patients, 30 had both preoperative and postoperative photographs and were the basis of the study. The age of the patients ranged from 19 to 56 years with the average age being 39 years. The postoperative follow-up averaged 9.5 months and the implants averaged 316 mL. There were no deaths, pulmonary embolism, deep vein thrombosis, or infected implants. Four patients had complications following surgery for an overall complication rate of 13%. Two patients developed an infected Gore-Tex suture. Two of these complications were treated with revision surgery. Five patients required reoperation for an overall reoperative rate of 16% (one patient was converted to a full mastopexy). As a result of this retrospective study, we have found the interlocking approach to periareolar augmentation/mastopexy to be a safe and reliable operation.

  14. Periareolar Augmentation Mastopexy with Interlocking Gore-Tex Suture, Retrospective Review of 50 Consecutive Patients

    Directory of Open Access Journals (Sweden)

    Johnny Franco

    2014-11-01

    Full Text Available BackgroundPeriareolar Augmentation Mastopexy is one of the most challenging operations in plastic surgery. Problems with scar quality, areolar widening, and distortion are frequent problems that interfere with a predictable result.MethodsA retrospective review was performed on fifty consecutive patients who underwent a periareolar augmentation mastopexy with the interlocking approach. Of the 50 patients, 30 had both preoperative and postoperative photographs and were the basis of the study.ResultsThe age of the patients ranged from 19 to 56 years with the average age being 39 years. The postoperative follow-up averaged 9.5 months and the implants averaged 316 mL. There were no deaths, pulmonary embolism, deep vein thrombosis, or infected implants. Four patients had complications following surgery for an overall complication rate of 13%. Two patients developed an infected Gore-Tex suture. Two of these complications were treated with revision surgery. Five patients required reoperation for an overall reoperative rate of 16% (one patient was converted to a full mastopexy.ConclusionsAs a result of this retrospective study, we have found the interlocking approach to periareolar augmentation/mastopexy to be a safe and reliable operation.

  15. Patología de pavimentos articulados Pathology of interlocking pavements

    Directory of Open Access Journals (Sweden)

    Carlos Hernando Higuera Sandoval

    2010-07-01

    Full Text Available Este artículo presenta los resultados de un proyecto de grado sobre patología de pavimentos articulados, el cual fue elaborado con el propósito de hacer una recolección de los deterioros típicos de los pavimentos articulados construidos con adoquines de concreto o de ladrillo; y de esta forma, elaborar un catálogo de deterioros para este tipo de estructuras que facilitará la identificación y cuantificación de los deterioros en una inspección visual. El segundo propósito de este proyecto, es la formulación para Colombia de una metodología que permita determinar el Índice de Condición de las estructuras de pavimentos articulados.This article presents the results of a thesis on pathology of interlocking pavements, which objective was to make a compilation of typical damages of interlocking pavements constructed with concrete or brick pavers and, in this way, to elaborate a catalogue of damages for this kind of structures which will make the identification and quantification of deteriorations possible in a visual inspection. The second purpose of this project is the formulation of a methodology which allows determining the Index of pavement conditions for Colombia.

  16. A review on past and present development on the interlocking loadbearing hollow block (ILHB) system

    Science.gov (United States)

    Bosro, M. Z. M.; Samad, A. A. A.; Mohamad, N.; Goh, W. I.; Tambichik, M. A.; Iman, M. A.

    2018-04-01

    Massive migration and increasing population in Malaysia has contributed to the increasing demand of quality and affordable housing. Over the past 50 years, the Malaysian housing industry has seen the growth of using conventional construction system such as reinforced concrete frame structures and bricks. The conventional system, as agreed by many researchers, causes delays and other disadvantages in some of the construction projects. Thus, the utilization of interlocking loadbearing hollow block (ILHB) system is needed to address these issues. This system has been identified as an alternative and sustainable building system for the construction industry in Malaysia which the PUTRA block system is the latest example of the ILHB developed. The system offers various advantages in terms of speed and cost in construction, strength, environmentally friendly and aesthetic qualities. Despite these advantages, this system has not been practically applied and develop in Malaysia. Therefore, this paper aims to review the past and present development of the interlocking loadbearing hollow block (ILHB) system that available locally and globally.

  17. On the modeling and characterization of an interlocked flexible electronic skin

    Science.gov (United States)

    Khalili, Nazanin; Shen, Xuechen; Naguib, Hani E.

    2017-04-01

    Development of an electronic skin with ultra-high pressure sensitivity is now of critical importance due its broad range of applications including prosthetic skins and biomimetic robotics. Microstructured conductive composite elastomers can acquire mechanical and electrical properties analogous to those of natural skin. One of the most prominent features of human skin is its tactile sensing property which can be mimicked in an electronic skin. Herein, an electrically conductive composite comprising polydimethylsiloxane and conductive fillers is used as a flexible and stretchable piezoresistive sensor. The electrical conductivity is induced within the elastomer matrix via carbon nanotubes whereas the piezoresistivity is obtained by means of microstructuring the surface of the substrate. An interlocked array of pyramids in micro-scale allows the change in the contact resistance between two thin layers of the composite upon application of an external load. Deformation of the interlocked arrays endows the sensor with an ultra-high sensitivity to the external pressures within the range of human skin perception. Moreover, using finite element analysis, the change in the contact are between the two layers was captured for different geometries. The structure of the sensor can be optimized through an optimization model in order to acquire maximum sensitivity.

  18. Tune resonance phenomena in the SPS and machine protection via fast position interlocking

    Energy Technology Data Exchange (ETDEWEB)

    Baer, Tobias [CERN, Genf (Switzerland); Universitaet Hamburg (Germany); DESY, Hamburg (Germany); Wenninger, Joerg; Bogey, Thierry; Araujo Meleiro, Berta [CERN, Genf (Switzerland)

    2010-07-01

    The 6911 m long Super Proton Synchrotron (SPS) at CERN with a peak energy of 450 GeV is at the top of the LHC preaccelerator-complex. Apart from the LHC, the SPS is with the Tevatron the accelerator with the largest stored beam energy of up to 2.5 MJ. The SPS has a known vulnerability to fast equipment failures that led to an uncontrolled loss of a high intensity beam in 2008, which resulted in major damage of a main dipole. The beam loss was caused by a fast tune decrease towards an integer resonance. Simulations and distinct experimental studies provide clear understanding of the beam dynamics at different SPS tune resonances. Diverging closed orbit oscillations, dispersion explosion and increased beta-beating are the driving effects that lead to a complete beam loss in as little as 10 turns (230 {mu}s) after reaching the stop band of the resonance. Dedicated experiments of fast failures of the main power converters reveal that the current interlock systems with a delay of 7-12 ms are much too slow for an adequate machine protection. To counteract the vulnerability of the SPS, current research focuses on a new fast position interlock system which is planned to become operational in the first quarter of 2010.

  19. Traction Converting Substation from Viewpoint of Feeding Interlocking Plant at Czech Railwayes

    Directory of Open Access Journals (Sweden)

    Radovan Dolecek

    2004-01-01

    Full Text Available This paper presents analyses current and voltage harmonic in traction converting substation 3 kV. It researches their rise and influence to three-phase cable line 6 kV, 50 Hz that is used for feeding interlocking plant. Processing of this task is arisen from requirement practice for line Pěčky - Poříčany - Rostoklaty where happened to adverse ratio in particular transmission line of feeding system. It is meant especially about backward influence traction substation rectifier Pečky to three - phase cable line 6 kV, 50 Hz. At the determinate lenght of the cable line, when resonace frequency of circuit transformer 22 kV/6 kV and the cable line 6 kV, 50 Hz is approached frequency 550 Hz and 650 Hz (i.e. 11 and 13 harmonic are happened to socalled "annulations input reactance of this circuit". That is caused by the leakage of current resonace frequency from traction converting substation to cable line. That proceduces additional losses and deformation waveform of voltage too. This deformation can be reflected on how interlocking plant is working. 

  20. Bacterial carbonate precipitation improves water absorption of interlocking compressed earth block (ICEB)

    Science.gov (United States)

    Zamer, M. M.; Irwan, J. M.; Othman, N.; Faisal, S. K.; Anneza, L. H.; Alshalif, A. F.; Teddy, T.

    2017-11-01

    Interlocking compressed earth blocks (ICEB) are soil based blocks that allows for mortarless construction. The addition of many alternative materials into interlocking block in order to improve the durability has been reported. However there are currently lack of report and evidence on the application of biocalcification or microbiologically induced calcite precipitation (MICP) in improving the engineering properties of ICEB. This paper evaluate the effect of UB in improving the water absorption properties of ICEB. This paper also provide the results on SEM analysis of addition of 1%, 3% and 5% UB in ICEB. The bacteria were added as partial replacement of limestone water in ICEB. The results showed the reduction of 14.72% with 5% UB on initial water absorption followed by the results for water absorption by 24-hour soaking which also indicates reduction of 14.68% with 5% UB on 28th days of testing compared to control specimen. It was expected that the reduction of water absorption was due to the plugging of pores by the bacterial calcite which prevent ingression of water in ICEB samples. Therefore this study hopes that the positive results from the UB as improving in water absorption of ICEB will lead to improve others ICEB properties and others construction materials.

  1. An in vitro biomechanical investigation of an interlocking nail system developed for buffalo tibia.

    Science.gov (United States)

    Bhat, S A; Aithal, H P; Kinjavdekar, P; Amarpal; Zama, M M S; Gope, P C; Pawde, A M; Ahmad, R A; Gugjoo, M B

    2014-01-01

    The objectives of the study were to determine the mechanical properties of a customized buffalo interlocking nail (BIN), intact buffalo tibia, and ostectomized tibia stabilized with BIN in different configurations, as well as to assess the convenience of interlocking nailing in buffalo tibia. The BIN (316L stainless steel, 12 mm diameter, 250 mm long, nine-hole solid nails with 10° proximal bend) alone was loaded in compression and three-point bending (n=4 each); intact tibiae and ostectomized tibiae (of buffaloes aged 5-8 years, weighing 300-350 kg) stabilized with BIN using 4.9 mm standard or modified locking bolts (4 or 8) in different configurations were subjected to axial compression, cranio-caudal three-point bending and torsion (n=4 each) using a universal testing machine. Mechanical parameters were determined from load-displacement curves and compared using Kruskal-Wallis test (ptesting modes. The strength of fixation constructs with eight locking bolts was significantly more than with four bolts. Overall strength of fixation with modified locking bolts was better than standard bolts. Based on technical ease and biomechanical properties, cranio-caudal insertion of bolts into the bone was found better than medio-lateral insertion. The eight bolt BIN-bone constructs could be useful to treat tibial fractures in large ruminants, especially buffaloes.

  2. Treatment of acute fractures of the femoral shaft with reamed intramedullary interlocking AO nails.

    Science.gov (United States)

    Umer, M; Niazi, A K; Hussain, D; Ahmad, M

    2004-08-01

    To review and audit our experience with closed intramedullary interlocking nailing for acute femoral shaft fractures. All patients admitted to The Aga Khan University Hospital, over the last six years and with a minimum follow-up of twelve months, with acute fractures of the femoral shaft were included in the study. All patients treated for established non-unions and infections or with pathological fractures were excluded from the study. There were 89 fractures, 74% of whom were closed and 50% were associated with other orthopedic injuries. Most of these were younger patients involved in high velocity road traffic accidents. The union rate was 88% with 4.4% of fractures going into non-union. The remaining 8% of the fractures went into a phase of delayed union, but ultimately united, making the overall success rate to be 95.6%. The mean time for union was 11.5 weeks. At the final clinical follow-up, 4% of the patients had minor pain, 7% had limp, 4% had leg length discrepancy of more than 2 cm and 4% had decreased range of motion at the hip or knee joints. We had a 4% rate of superficial infection. There were 3 cases of pudendal nerve neuropraxia and 2 cases of deep vein thrombosis. Intramedullary Interlocking nailing is a safe and effective treatment modality for acute fractures of the femoral shaft. Proper surgical decision making regarding static versus dynamic mode of locking can avoid problems of delayed union.

  3. Abating coal tar seepage into surface water bodies using sheet piles with sealed interlocks

    International Nuclear Information System (INIS)

    Collingwood, B.I.; Boscardin, M.D.; Murdock, R.F.

    1995-01-01

    A former coal tar processing facility processed crude coal tar supplied from manufactured gas plants in the area. Coal-tar-contaminated ground water from the site was observed seeping through an existing timber bulkhead along a tidal river and producing a multicolored sheen on the surface of the river. As part of a short-term measure to abate the seepage into the river, 64-m long anchored sheet pile wall with sheet pile wing walls at each end was constructed inland of the of the timber bulkhead. The sheet piles extended to low-permeability soils at depth and the interlocks of the sheet piles were provided with polyurethane rubber seals. Based on postconstruction observations for leakage and sheens related to leakage, the steel sheet piles with polyurethane rubber interlock seals appeared to provide a successful seal and abate coal-tar-contaminated ground water seepage into the river. The tie rod penetration sealing proved to be a more problematic detail, but through several postconstruction grouting episodes, an effective seal was produced

  4. Effect of microtrichia on the interlocking mechanism in the Asian ladybeetle, Harmonia axyridis (Coleoptera: Coccinellidae).

    Science.gov (United States)

    Sun, Jiyu; Liu, Chao; Bhushan, Bharat; Wu, Wei; Tong, Jin

    2018-01-01

    The hindwings of beetles are folded under the elytra when they are at rest but are extended during flight, which can provide bioinspiration for the design of deployable micro air vehicles (MAVs). Beetle hindwings must be able to be both securely locked under the elytra and freely extended for flight, depending on the required action. To investigate the locking mechanism, this study used environmental scanning electron microscopy (ESEM) to examine the microstructures of the elytra, hindwings and abdomen of the Asian ladybeetle, Harmonia axyridis (Pallas, 1773). On the ventral side (VS) of the elytra, the microtrichia show a transitional structure from the lateral edge to the medial edge. On the hindwing surface, the folded regions were observed on both the dorsal side (DS) and the VS. On the abdomen, the microtrichia between the abdominal segments show a cyclical change from sparse to dense in each segment in the middle of the abdomen. Furthermore, the different directions of microtrichia that lead to self-locking friction on the surfaces of the hindwing, elytron and abdomen appear to facilitate interlocking. A model for the interlocking of the hindwings of the H. axyridis was established, and its underlying mechanism is discussed.

  5. Bio-inspired ``jigsaw''-like interlocking sutures: Modeling, optimization, 3D printing and testing

    Science.gov (United States)

    Malik, I. A.; Mirkhalaf, M.; Barthelat, F.

    2017-05-01

    Structural biological materials such as bone, teeth or mollusk shells draw their remarkable performance from a sophisticated interplay of architectures and weak interfaces. Pushed to the extreme, this concept leads to sutured materials, which contain thin lines with complex geometries. Sutured materials are prominent in nature, and have recently served as bioinspiration for toughened ceramics and glasses. Sutures can generate large deformations, toughness and damping in otherwise all brittle systems and materials. In this study we examine the design and optimization of sutures with a jigsaw puzzle-like geometry, focusing on the non-linear traction behavior generated by the frictional pullout of the jigsaw tabs. We present analytical models which accurately predict the entire pullout response. Pullout strength and energy absorption increase with higher interlocking angles and for higher coefficients of friction, but the associated high stresses in the solid may fracture the tabs. Systematic optimization reveals a counter-intuitive result: the best pullout performance is achieved with interfaces with low coefficient of friction and high interlocking angle. We finally use 3D printing and mechanical testing to verify the accuracy of the models and of the optimization. The models and guidelines we present here can be extended to other types of geometries and sutured materials subjected to other loading/boundary conditions. The nonlinear responses of sutures are particularly attractive to augment the properties and functionalities of inherently brittle materials such as ceramics and glasses.

  6. An analytical hierarchical model explaining the robustness and flaw-tolerance of the interlocking barb-barbule structure of bird feathers

    Science.gov (United States)

    Chen, Qiang; Gorb, Stanislav; Kovalev, Alexander; Li, Zhiyong; Pugno, Nicola

    2016-10-01

    Feathers can fulfill their aerodynamic function only if the pennaceous vane forms an airfoil stabilized by robust interlocking between barbules. Thus, revealing the robustness of the interlocking mechanical behavior of the barbules is very important to understand the function and long-term resilience of bird feathers. This paper, basing on the small- and large-beam deflection solutions, presents a hierarchical mechanical model for deriving the critical delamination conditions of the interlocking barbules between two adjacent barbs in bird feathers. The results indicate a high robustness and flaw-tolerant design of the structure. This work contributes to the understanding of the mechanical behavior of the robust interlocking barb-barbule structure of the bird feather, and provides a basis for design of feather-inspired materials with robust interlocking mechanism, such as advanced bio-inspired micro-zipping devices.

  7. Observing Convective Aggregation

    Science.gov (United States)

    Holloway, Christopher E.; Wing, Allison A.; Bony, Sandrine; Muller, Caroline; Masunaga, Hirohiko; L'Ecuyer, Tristan S.; Turner, David D.; Zuidema, Paquita

    2017-11-01

    Convective self-aggregation, the spontaneous organization of initially scattered convection into isolated convective clusters despite spatially homogeneous boundary conditions and forcing, was first recognized and studied in idealized numerical simulations. While there is a rich history of observational work on convective clustering and organization, there have been only a few studies that have analyzed observations to look specifically for processes related to self-aggregation in models. Here we review observational work in both of these categories and motivate the need for more of this work. We acknowledge that self-aggregation may appear to be far-removed from observed convective organization in terms of time scales, initial conditions, initiation processes, and mean state extremes, but we argue that these differences vary greatly across the diverse range of model simulations in the literature and that these comparisons are already offering important insights into real tropical phenomena. Some preliminary new findings are presented, including results showing that a self-aggregation simulation with square geometry has too broad distribution of humidity and is too dry in the driest regions when compared with radiosonde records from Nauru, while an elongated channel simulation has realistic representations of atmospheric humidity and its variability. We discuss recent work increasing our understanding of how organized convection and climate change may interact, and how model discrepancies related to this question are prompting interest in observational comparisons. We also propose possible future directions for observational work related to convective aggregation, including novel satellite approaches and a ground-based observational network.

  8. The business prestige: A preliminary study based on interlocks within companies El prestigi empresarial: Anàlisi a través de les conselleries creuades The business prestige: A preliminary study based on interlocks within companies

    Directory of Open Access Journals (Sweden)

    David Gonzalez-Prieto

    2011-11-01

    Full Text Available Purpose: The literature on interlocked directorate or interlocks has proposed the presence of cross-directors as an influential factor in the prestige of a firm (Mizruchi, 1996. This theory is based on the fact that, by having multiple companies with interlocks within them, major stakeholders of the company ought to have a higher perception of prestige. The aim of this preliminary study is to present an exploratory study and suggest future research lines on this issue. Design/methodology/approach: In a first preliminary study, we evaluate the interlocks network comprising companies belonging to the ranking established by the MERCO report in Spain for the year 2010. This is a well-known ranking of corporate reputation in Spain used in recent articles (Luna & Fernandez, 2010. For further analysis, other variables are considered as being quoted in the Spanish market benchmark index, IBEX 35, and the location of the headquarters.Findings: Significant positive relationship was obtained between the number of directorships shared with other public companies and the perceived prestige that stakeholders perceive from the firm. Similarly, we obtain significant positive correlation between the prestige and being listed on the IBEX 35. Finally, we identified banking, construction and energy sectors as the ones that use interlocking directorates more intensively.Research limitations: The results of this preliminary study show the viability of future studies about prestige and interlocks (Mizruchi, 1996. For the validation of the theory described in this study, it should be replicated in different regions and, with larger samples, to observe the effect that interlocks have on the perception of prestige of the company.Practical implications / Originality/value: This is among the first studies showing the existence of a relationship between interlocks and business prestige. It highlights the importance of the composition of the boards for the perceived prestige

  9. Influence of coarse aggregate on shear resistance of self-consolidating concrete beams

    Directory of Open Access Journals (Sweden)

    G. SAVARIS

    Full Text Available Abstract Self-consolidating concrete is characterized by its high flowability, which can be achieved with the addition of superplasticizer and the reduction of the amount and size of coarse aggregates in the concrete mix. This high flowability allows the concrete to properly fill the formwork without any mechanical vibration. The reduction in volume and particle size of the coarse aggregates may result in lower shear strength of beams due to a reduced aggregate interlock. Therefore, an experimental investigation was conducted to evaluate the influence of the reduction in the volume fraction and the nominal size of coarse aggregate on concrete shear strength of self-consolidating beams. Six concrete mixes were produced, four self-consolidating and two conventionally vibrated. A total of 18 beams, with flexural reinforcement but without shear reinforcement were cast. These beams were tested under a four-point loading condition. Their failure modes, cracking patterns and shear resistances were evaluated. The obtained shear resistances were compared to the theoretical values given by the ACI-318 and EC-2 codes. The results demonstrated a lower shear resistance of self-consolidating concrete beams, caused mainly due to the reduced aggregate size.

  10. Interlocking Toy Building Blocks as Hands-On Learning Modules for Blind and Visually Impaired Chemistry Students

    Science.gov (United States)

    Melaku, Samuel; Schreck, James O.; Griffin, Kameron; Dabke, Rajeev B.

    2016-01-01

    Interlocking toy building blocks (e.g., Lego) as chemistry learning modules for blind and visually impaired (BVI) students in high school and undergraduate introductory or general chemistry courses are presented. Building blocks were assembled on a baseplate to depict the relative changes in the periodic properties of elements. Modules depicting…

  11. Analysis of operator support method based on intelligent dynamic interlock in lead-cooled fast reactor simulator

    International Nuclear Information System (INIS)

    Xu, Peng; Wang, Jianye; Yang, Minghan; Wang, Weitian; Bai, Yunqing; Song, Yong

    2017-01-01

    Highlights: • We development an operator support method based on intelligent dynamic interlock. • We offer an integrated aid system to reduce the working strength of operators. • The method can help operators avoid dangerous, irreversible operation. • This method can be used in the fusion research reactor in the further. - Abstract: In nuclear systems, operators have to carry out corrective actions when abnormal situations occur. However, operators might make mistakes under pressure. In order to avoid serious consequences of the human errors, a new method for operators support based on intelligent dynamic interlock was proposed. The new method based on full digital instrumentation and control system, contains real-time alarm analysis process, decision support process and automatic safety interlock process. Once abnormal conditions occur, necessary safety interlock parameter based on analysis of real-time alarm and decision support process can be loaded into human-machine interfaces and controllers automatically, and avoid human errors effectively. Furthermore, the new method can make recommendations for further use and development of this technique in nuclear power plant or fusion research reactor.

  12. [Electromagnetic navigation interlocking intramedullary nail technology for treatment of femoral shaft fractures].

    Science.gov (United States)

    Zuo, Kangkang; Qin, Wei; Guo, Qing; Palati-Ababaikeli; Qiao, Peiliu; Shen, Mingquan; Yin, Lele; Pan, Qilin; Xu, Xiaoxiong

    2014-10-01

    To explore the value of electromagnetic navigation interlocking intramedullary nail in the treatment of femoral shaft fracture. Between July 2012 and October 2013, 53 cases of femoral shaft fracture were treated. There were 40 males and 13 females, aged 16-52 years (mean, 38.3 years). The causes of injury were traffic accident in 28 cases, falling from height in 11 cases, falling in 7 cases, crush injury in 4 cases, and other in 3 cases. Of 53 cases, there were 3 cases of open fracture (Gustilo I degree) and 50 cases of closed fracture. Fracture was located in the proximal femur in 17 cases, middle femur in 29 cases, and distal femur in 7 cases. According to Winquist classification, 7 cases were rated as type I, 8 cases as type II, 22 cases as type III, and 16 cases as type IV; according to AO classification, 18 cases were rated as type 32-A, 28 cases as type 32-B, and 7 cases as type 32-C. The time from injury to operation was 3-11 days (mean, 5 days). Distal interlocking intramedullary nail was implanted using electromagnetic navigation. The distal locking nail operation with interlocking intramedullary nail was successfully completed under electromagnetic navigation; the one-time success rate of distal locking nail operation reached 100%; and the locking nail time was 5.0-9.5 minutes (mean, 7.0 minutes). Healing of incision by first intention was obtained after operation, and no complication of skin necrosis, infection, and sinus tract occurred. Fifty-three cases were all followed up 5-12 months (mean, 9 months). One case had hip pain and weaken middle gluteal muscle strength, and the symptoms disappeared after removing the nail. During the follow-up period, no broken nails, nail exit, infection, or re-fracture occurred. All fractures achieved clinical healing, and the healing time was 8-22 weeks (mean, 14.5 weeks). In 49 patients followed up 8 months, the Lysholm score was excellent in 44 cases, good in 4 cases, and acceptable in 1 case, with an excellent and

  13. Platelet aggregation following trauma

    DEFF Research Database (Denmark)

    Windeløv, Nis A; Sørensen, Anne M; Perner, Anders

    2014-01-01

    We aimed to elucidate platelet function in trauma patients, as it is pivotal for hemostasis yet remains scarcely investigated in this population. We conducted a prospective observational study of platelet aggregation capacity in 213 adult trauma patients on admission to an emergency department (ED...

  14. Aggregates, broccoli and cauliflower

    Science.gov (United States)

    Grey, Francois; Kjems, Jørgen K.

    1989-09-01

    Naturally grown structures with fractal characters like broccoli and cauliflower are discussed and compared with DLA-type aggregates. It is suggested that the branching density can be used to characterize the growth process and an experimental method to determine this parameter is proposed.

  15. Geoinformation Generalization by Aggregation

    Directory of Open Access Journals (Sweden)

    Tomislav Jogun

    2016-12-01

    Full Text Available Geoinformation generalization can be divided into model generalization and cartographic generalization. Model generalization is the supervised reduction of data in a model, while cartographic generalization is the reduction of the complexity of map content adapted to the map scale, and/or use by various generalization operators (procedures. The topic of this paper is the aggregation of geoinformation. Generally, aggregation is the joining of nearby, congenial objects, when the distance between them is smaller than the minimum sizes. Most researchers in geoinformation generalization have focused on line features. However, the appearance of web-maps with point features and choropleth maps has led to the development of concepts and algorithms for the generalization of point and polygonal features. This paper considers some previous theoretical premises and actual examples of aggregation for point, line and polygonal features. The algorithms for aggregation implemented in commercial and free GIS software were tested. In the conclusion, unresolved challenges that occur in dynamic cartographic visualizations and cases of unusual geometrical features are highlighted.

  16. The Community Structure of the European Network of Interlocking Directorates 2005–2010

    Science.gov (United States)

    Heemskerk, Eelke M.; Daolio, Fabio; Tomassini, Marco

    2013-01-01

    The boards of directors at large European companies overlap with each other to a sizable extent both within and across national borders. This could have important economic, political and management consequences. In this work we study in detail the topological structure of the networks that arise from this phenomenon. Using a comprehensive information database, we reconstruct the implicit networks of shared directorates among the top 300 European firms in 2005 and 2010, and suggest a number of novel ways to explore the trans-nationality of such business elite networks. Powerful community detection heuristics indicate that geography still plays an important role: there exist clear communities and they have a distinct national character. Nonetheless, from 2005 to 2010 we observe a densification of the boards interlocks network and a larger transnational orientation in its communities. Together with central actors and assortativity analyses, we provide statistical evidence that, at the level of corporate governance, Europe is getting closer. PMID:23894318

  17. The use of microprocessors at TRIUMF in the control of radiation safety interlock systems

    International Nuclear Information System (INIS)

    King, L.

    1988-01-01

    At TRIUMF the cyclotron vault, all primary beam lines, and each experimental area has a dedicated control unit to manage the safety interlock control of the area lockup sequence, beam blocker drive and area access. Typically each area has 24 devices which are monitored to control 16 outputs. These control units (Area Safety Units) were first implemented through the use of relay logic. The relay logic was reliable but difficult to modify to incorporate changes to the areas. In 1979 it was decided to use microprocessors in the form of single board computers to control the Area Safety Units. The details of the hardware and software is discussed as well as the advantages of microprocessor control

  18. Testing the permeability and corrosion resistance of micro-mechanically interlocked joints

    Science.gov (United States)

    Byskov-Nielsen, Jeppe; Holm, Allan H.; Højsholt, Rune; Sá, Pedro; Balling, Peter

    2011-09-01

    Micro-mechanical interlocking (MMI) can be applied to create new and interesting composite materials. We have employed laser structuring to achieve MMI between stainless steel and plastic with extremely high joint strength. However, the water permeability and corrosion resistance of the joint must be examined. For many industrially relevant applications it is important to keep water away from certain parts and to prevent the sample from corroding. A thorough study of the permeability of the interconnected samples at different temperatures and after employing different laser-structuring techniques is conducted. The permeability seems to be consistent with the Hagen-Poiseuille equation independent of the laser structuring technique and is orders of magnitudes larger than the diffusion rate through the plastic. Two different types of corrosion tests have been undertaken, and we show that care must be taken in order not to degrade the corrosion resistance of the sample to an unacceptable level.

  19. Reuse of mining dams waste for the processing of interlocking blocks for paving

    International Nuclear Information System (INIS)

    Machado, Raissa Ribeiro Lima; Ribeiro, Guilherme Borges; Silva, Sidney Nicodemos da

    2014-01-01

    The environmental impact of mining dam residues can be mitigated by their reuse in the production of interlocking blocks for pavements with a mechanical strength greater than 50 MPa. From the mixture of cement CPV-ARI, sand and gravel, the characterization of the mechanical and physicochemical properties was performed by the following procedures: SEM, FRX, XRD, compression tests and thermal analysis (DSC). These blocks produced from these residues can be considered an economical alternative for the mining depletion cycle in the State of Minas Gerais. This work sought to improve the traces with the replacement the sand of the rivers bed by residues of mining dams that can represent an opportunity for generation of employment and income

  20. The community structure of the European network of interlocking directorates 2005-2010.

    Science.gov (United States)

    Heemskerk, Eelke M; Daolio, Fabio; Tomassini, Marco

    2013-01-01

    The boards of directors at large European companies overlap with each other to a sizable extent both within and across national borders. This could have important economic, political and management consequences. In this work we study in detail the topological structure of the networks that arise from this phenomenon. Using a comprehensive information database, we reconstruct the implicit networks of shared directorates among the top 300 European firms in 2005 and 2010, and suggest a number of novel ways to explore the trans-nationality of such business elite networks. Powerful community detection heuristics indicate that geography still plays an important role: there exist clear communities and they have a distinct national character. Nonetheless, from 2005 to 2010 we observe a densification of the boards interlocks network and a larger transnational orientation in its communities. Together with central actors and assortativity analyses, we provide statistical evidence that, at the level of corporate governance, Europe is getting closer.

  1. Tensile Damage Mechanism of 3-D Angle-Interlock Woven Composite using Acoustic Emission Events Monitoring

    Directory of Open Access Journals (Sweden)

    Ma Qian

    2018-03-01

    Full Text Available The quasi-static tensile damage behavior of one type of layer-to-layer 3-Dimensional Angle-interlock Woven Composite (3DAWC was tested and analyzed in this paper. Incorporated with the acoustic emission (AE events monitoring, the mechanical behavior of the 3DAWC under tensile loading condition was characterized. The Load-Extension curve, Load/AE events-Time curves occurred during the entire testing process and tensile damage modes were recorded to characterize and summarize the mechanical properties and damage mechanism of the 3DAWC subjected to tensile loading. It was found that the tensile damage of the 3DAWC could be summarized into 3 steps. And each step has a distinct primary damage mode. Moreover, the resin cracks, resin-yarn interface debonding and yarn breakages were the main damage modes for the 3DAWC.

  2. Groovy as Domain-Specific Language in the Software Interlock System

    CERN Document Server

    Wozniak, J; Kruk, G

    2014-01-01

    After over 7 years in operation the Software Interlock System (SIS) has become an indispensable and mission critical controls tool covering many operational areas from general machine protection to diagnostics. The growing number of running instances as much as the size of existing configurations have increased both the complexity and maintenance cost of running the SIS infrastructure. In response to those issues, new ways of configuring the system have been investigated aiming at simplifying the configuration process by making it faster, more user-friendly and understandable for wider audiences and domain experts alike. As one of the possible choices the Groovy scripting language has been considered as being particularly well suited for writing a custom Domain-Specific Language (DSL) due to its built-in language features like native syntax constructs, command chain expressions, hierarchical structures with builders, closures or Abstract Syntax Tree (AST) transformations. This document explains best practices...

  3. Radiation interlocks: The choice between conventional hard-wired logic and computer-based systems

    International Nuclear Information System (INIS)

    Crook, K.F.

    1986-11-01

    During the past few years, the use of computers in radiation safety systems has become more widespread. This is not surprising given the ubiquitous nature of computers in the modern technological world. But is a computer a good choice for the central logic element of a personnel safety system. Recent accidents at computer controlled medical accelerators would indicate that extreme care must be exercised if malfunctions are to be avoided. The Department of Energy has recently established a sub-committee to formulate recommendations on the use of computers in safety systems for accelerators. This paper will review the status of the committee's recommendations, and describe radiation protection interlock systems as applied to both accelerators and to irradiation facilities. Comparisons are made between the conventional relay approach and designs using computers. 6 refs., 6 figs

  4. Transparent superhydrophobic coating application to the interlocking clay block for the microbial growth mitigation

    Science.gov (United States)

    Nimittrakoolchai, O.; Suwan, M.; Supothina, S.

    2017-12-01

    Interlocking clay block is of widespread use in many countries due to its less labor-intensive design. The block comprises of considerable amount of pore structures; therefore water can easily penetrate into it causing deterioration by natural weathering as well as the growth of microbes on its surface. In this present work, a transparent, superhydrophobic coating was applied onto the block’s surface to prevent water absorption. The coating which is a poly(methyl hydrogensiloxane) base containing fumed SiO2 nanoparticle was designed to possess surface topographic feature similar to that of the lotus leaf. After coating the block with the superhydrophobic compound, its water absorption decreased from 11.5 to 4.8% and porosity substantially decreased from 22.5 to 9.2%, while bulk and apparent densities did not change. Accelerated weathering test revealed that the coating had good stability. The coated samples exhibited growth inhibition of algae.

  5. Metacarpophalangeal joint of the thumb arthrodesis using intramedullary interlocking screws XMCP™.

    Science.gov (United States)

    Novoa-Parra, C N; Montaner-Alonso, D; Morales-Rodríguez, J

    2017-09-04

    The study objective was to assess the results of a thumb metacarpophalangeal joint (MCPJ) arthrodesis using intramedullary interlocking screws at 25°, XMCP ™ (Extremity Medical, Parsippany, NJ). Radiographs evaluated the angle of arthrodesis, time of fusion and fixation of the implant. Clinical and functional outcomes were assessed using the DASH questionnaire and the VAS scale. Any complications found during surgery or the follow-up period were noted. We studied 9 patients. The mean follow-up was 27.6 months. Patients showed clinical and radiological evidence of fusion in an average of 8 weeks, the angle of fusion was 25°. There were no complications and no implant had to be removed. The XMCP™ system provides a reliable method for MCPJ arthrodesis for several indications and can be used with other procedures in the complex hand. Copyright © 2017 SECOT. Publicado por Elsevier España, S.L.U. All rights reserved.

  6. An active interlock system for the NSLS x-ray ring insertion devices

    International Nuclear Information System (INIS)

    Nawrocky, R.J.; Biscardi, R.; Dabrowski, J.; Flannigan, J.; Ramamoorthy, S.; Rothman, J.; Smith, J.; So, I.; Thomas, M.; Decker, G.

    1991-01-01

    This paper describes the design and operation of an active interlock system which has been installed in the NSLS X-ray electron storage ing to protect the vacuum chamber from thermal damage by mis-steered high power photon beams from insertion devices (IDs). the system employs active beam position detectors to monitor beam motion in the ID straight sections and solid state logic circuitry to ''dump'' the stored beam in the event of a fault condition by interrupting the rf. To ensure a high degree of reliability, redundancy and continuous automatic checking has been incorporated into the design. Overall system integrity is checked periodically with beam at safe levels of beam current. 2 refs., 3 figs

  7. Photoswitchable interlocked thiodiglycolamide as a cocatalyst of a chalcogeno-Baylis-Hillman reaction.

    Science.gov (United States)

    Martinez-Cuezva, Alberto; Saura-Sanmartin, Adrian; Nicolas-Garcia, Tomas; Navarro, Cristian; Orenes, Raul-Angel; Alajarin, Mateo; Berna, Jose

    2017-05-01

    En route to a photoswitchable interlocked catalyst we have proved the ability of thiodiglycolamide to act as a template in the formation of hydrogen-bonded [2]rotaxanes. X-ray diffraction studies reveal the shielding of the sulfide atom by the macrocycle. A series of molecular shuttles are described as having an isomerizable fumaramide and thiodiglycolamide binding sites for controlling the relative ring position at will. By employing these systems as photoregulated catalysts, the TiCl 4 -mediated chalcogeno-Morita-Baylis-Hillman reaction is tested. In the presence of the maleamide shuttle, in which the sulfide function is encapsulated by the macrocycle, a complete loss in control of the geometry of the produced aldol is observed. The E -aldol adduct is predominantly obtained when the photoisomerized fumaramide shuttle, in which the sulfide function is exposed, is used.

  8. D0 Central Tracking Solenoid Energization, Controls, Interlocks and Quench Protection Initial Validation Procedures

    International Nuclear Information System (INIS)

    Jaskierny, W.; Hance, R.

    1998-01-01

    This note presents the inspection and tests to be performed on the DZERO solenoid energization, controls, interlocks and quench protection system before it is energized for the first time. This test is to be performed with a 5000A jumper at the end of the bus instead of the solenoid. This system is based in DZERO room 511. A copy of this note shall be annotated, signed and dated by the person coordinating the procedure; and filed with the system maintenance records. Annotations shall include comments about any aspect of the procedure that is abnormal or unsuccessful. The following inspections and tests shall be performed by persons knowledgeable about the system. Each individual test step should be reviewed and understood before proceeding with that step.

  9. Control/interlock/display system for EBT-P using commercially-available hardware and firmware

    International Nuclear Information System (INIS)

    Schmitt, R.J.

    1983-01-01

    For the EBT-P project, alternative commercially-available hardware, software and firmware have been employed for control, interlock and data display functions. This paper describes the criteria and rationale used to select that commercial equipment and discusses the important features of the equipment chosen, especially programmable controllers. Additional discussion is centered on interface problems which are encountered upon attempts to integrate equipment from several vendors. Some solutions to these problems are discussed. Details of software and hardware performance during tests are presented. The extent to which the EBT-P hardware and software configuration addresses and resolves various issues is discussed. Several areas have been uncovered in which relatively slight improvements/modifications of commercial programmable controller firmware would significantly improve the capability of this type of hardware in fusion control applications. These improvements are discussed in detail

  10. The community structure of the European network of interlocking directorates 2005-2010.

    Directory of Open Access Journals (Sweden)

    Eelke M Heemskerk

    Full Text Available The boards of directors at large European companies overlap with each other to a sizable extent both within and across national borders. This could have important economic, political and management consequences. In this work we study in detail the topological structure of the networks that arise from this phenomenon. Using a comprehensive information database, we reconstruct the implicit networks of shared directorates among the top 300 European firms in 2005 and 2010, and suggest a number of novel ways to explore the trans-nationality of such business elite networks. Powerful community detection heuristics indicate that geography still plays an important role: there exist clear communities and they have a distinct national character. Nonetheless, from 2005 to 2010 we observe a densification of the boards interlocks network and a larger transnational orientation in its communities. Together with central actors and assortativity analyses, we provide statistical evidence that, at the level of corporate governance, Europe is getting closer.

  11. A pH-Dependent, Mechanically Interlocked Switch: Organometallic [2]Rotaxane vs. Organic [3]Rotaxane.

    Science.gov (United States)

    Altmann, Philipp J; Pöthig, Alexander

    2017-12-04

    We present the first [2]rotaxane featuring a functional organometallic host. In contrast to the known organic scaffolds, this assembly shows a high post-synthetic modifiability. The reactivity of the Ag 8 pillarplex host is fully retained, as is exemplified by the first transmetalation in a rotaxane framework to provide the respective Au 8 analogue. Additionally, a transformation under acidic conditions to give a purely organic [3]rotaxane is demonstrated which is reversible upon addition of a suitable base, rendering the assembly a pH-dependent switch. Hereby, it is shown that the mechanically interlocked nature of the system enhances the kinetic stability of the NHC host complex by a factor of >1000 and corresponds to the first observation of a stabilizing "rotaxand effect". © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. External jig-aided intramedullary interlocking nailing of diaphyseal fractures: experience from a tropical developing centre.

    Science.gov (United States)

    Ikpeme, Ikpeme; Ngim, Ngim; Udosen, Anthony; Onuba, Obiora; Enembe, Okokon; Bello, Segun

    2011-01-01

    Intramedullary interlocking nailing for diaphyseal fractures is a standard treatment option in affluent societies. These procedures are often performed under image intensifier guidance. The cost of these gadgets precludes their common use in resource poor regions. External jig-aided intramedullary interlocking nailing is relatively cheap and offers the chance for performing these procedures in resource poor regions. The aim of this study was to document the advantages, challenges and outcome of this form of treatment in a resource poor setting. The Surgical Implant Generation Network (SIGN) implants and instrumentation were used for this study. Thirty-seven limbs in 35 patients were included. There were 30 males and five females giving a ratio of 6:1. The mean age was 35 ± 11.9 years with a range of 15-61 years. The femur and tibia were the bones studied with a total of 23 and 14 fractures, respectively (ratio 1.6:1). There were 14 comminuted fractures, two segmented fractures, six mal-unions, eight non-unions and seven simple fractures. Road traffic accidents were the most common cause of injuries with motorcycle accidents accounting for 19 (57.4%) cases. The mean follow-up period was 22 ± 5.32 months, mean time to union was 16.9 ± 5.4 weeks and the major complication was osteomyelitis (10.8%). We conclude that this is a viable treatment option for musculoskeletal injuries in resource poor regions. Education to encourage early acceptance of surgical intervention and reduced patronage of traditional bone setting for injudicious interventions can reduce the infective complication rates.

  13. Sustainable aggregates production : green applications for aggregate by-products.

    Science.gov (United States)

    2015-06-01

    Increased emphasis in the construction industry on sustainability and recycling requires production of : aggregate gradations with lower dust (cleaner aggregates) and smaller maximum sizeshence, increased : amount of quarry by-products (QBs). QBs ...

  14. Concrete produced with recycled aggregates

    Directory of Open Access Journals (Sweden)

    J. J. L. Tenório

    Full Text Available This paper presents the analysis of the mechanical and durable properties of recycled aggregate concrete (RAC for using in concrete. The porosity of recycled coarse aggregates is known to influence the fresh and hardened concrete properties and these properties are related to the specific mass of the recycled coarse aggregates, which directly influences the mechanical properties of the concrete. The recycled aggregates were obtained from construction and demolition wastes (CDW, which were divided into recycled sand (fine and coarse aggregates. Besides this, a recycled coarse aggregate of a specific mass with a greater density was obtained by mixing the recycled aggregates of the CDW with the recycled aggregates of concrete wastes (CW. The concrete was produced in laboratory by combining three water-cement ratios, the ratios were used in agreement with NBR 6118 for structural concretes, with each recycled coarse aggregates and recycled sand or river sand, and the reference concrete was produced with natural aggregates. It was observed that recycled aggregates can be used in concrete with properties for structural concrete. In general, the use of recycled coarse aggregate in combination with recycled sand did not provide good results; but when the less porous was used, or the recycled coarse aggregate of a specific mass with a greater density, the properties of the concrete showed better results. Some RAC reached bigger strengths than the reference concrete.

  15. Qualitative and temporal aggregation

    OpenAIRE

    Kakarot-Handtke, Egmont

    2011-01-01

    Behavioral assumptions, rational or otherwise, are not solid enough to be eligible as first principles of theoretical economics. Hence all endeavors to lay the formal foundation on a new site and at a deeper level actually need no further vindication. The present paper suggests three non-behavioral axioms as groundwork and applies them to the analysis of qualitative and temporal aggregation in the pure consumption economy. It turns out that the structural axiom set is self-similar with regard...

  16. Migrativity of aggregation functions

    Czech Academy of Sciences Publication Activity Database

    Bustince, H.; Montero, J.; Mesiar, Radko

    2009-01-01

    Roč. 160, č. 6 (2009), s. 766-777 ISSN 0165-0114 R&D Projects: GA ČR GA402/08/0618 Institutional research plan: CEZ:AV0Z10750506 Keywords : Aggregation functions * Associativity * Bisymmetry * Migrativity * Nullnorms * t-Norms * Uninorms Subject RIV: BA - General Mathematics Impact factor: 2.138, year: 2009 http://library.utia.cas.cz/separaty/2009/E/masiar-migrativityofaggregationfunctions.pdf

  17. Familial Aggregation of Insomnia.

    Science.gov (United States)

    Jarrin, Denise C; Morin, Charles M; Rochefort, Amélie; Ivers, Hans; Dauvilliers, Yves A; Savard, Josée; LeBlanc, Mélanie; Merette, Chantal

    2017-02-01

    There is little information about familial aggregation of insomnia; however, this type of information is important to (1) improve our understanding of insomnia risk factors and (2) to design more effective treatment and prevention programs. This study aimed to investigate evidence of familial aggregation of insomnia among first-degree relatives of probands with and without insomnia. Cases (n = 134) and controls (n = 145) enrolled in a larger epidemiological study were solicited to invite their first-degree relatives and spouses to complete a standardized sleep/insomnia survey. In total, 371 first-degree relatives (Mage = 51.9 years, SD = 18.0; 34.3% male) and 138 spouses (Mage = 55.5 years, SD = 12.2; 68.1% male) completed the survey assessing the nature, severity, and frequency of sleep disturbances. The dependent variable was insomnia in first-degree relatives and spouses. Familial aggregation was claimed if the risk of insomnia was significantly higher in the exposed (relatives of cases) compared to the unexposed cohort (relatives of controls). The risk of insomnia was also compared between spouses in the exposed (spouses of cases) and unexposed cohort (spouses of controls). The risk of insomnia in exposed and unexposed biological relatives was 18.6% and 10.4%, respectively, yielding a relative risk (RR) of 1.80 (p = .04) after controlling for age and sex. The risk of insomnia in exposed and unexposed spouses was 9.1% and 4.2%, respectively; however, corresponding RR of 2.13 (p = .28) did not differ significantly. Results demonstrate evidence of strong familial aggregation of insomnia. Additional research is warranted to further clarify and disentangle the relative contribution of genetic and environmental factors in insomnia. © Sleep Research Society 2016. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.

  18. Concrete produced with recycled aggregates

    OpenAIRE

    Tenório, J. J. L.; Gomes, P. C. C.; Rodrigues, C. C.; Alencar, T. F. F. de

    2012-01-01

    This paper presents the analysis of the mechanical and durable properties of recycled aggregate concrete (RAC) for using in concrete. The porosity of recycled coarse aggregates is known to influence the fresh and hardened concrete properties and these properties are related to the specific mass of the recycled coarse aggregates, which directly influences the mechanical properties of the concrete. The recycled aggregates were obtained from construction and demolition wastes (CDW), which were d...

  19. A Focus on Triazolium as a Multipurpose Molecular Station for pH-Sensitive Interlocked Crown-Ether-Based Molecular Machines.

    Science.gov (United States)

    Coutrot, Frédéric

    2015-10-01

    The control of motion of one element with respect to others in an interlocked architecture allows for different co-conformational states of a molecule. This can result in variations of physical or chemical properties. The increase of knowledge in the field of molecular interactions led to the design, the synthesis, and the study of various systems of molecular machinery in a wide range of interlocked architectures. In this field, the discovery of new molecular stations for macrocycles is an attractive way to conceive original molecular machines. In the very recent past, the triazolium moiety proved to interact with crown ethers in interlocked molecules, so that it could be used as an ideal molecular station. It also served as a molecular barrier in order to lock interlaced structures or to compartmentalize interlocked molecular machines. This review describes the recently reported examples of pH-sensitive triazolium-containing molecular machines and their peculiar features.

  20. Breath Alcohol Ignition Interlock Devices : Policy and Implementing Implications [Mobile .MP4 (480x320/29.97fps/13.9MB)

    Science.gov (United States)

    2011-01-01

    The goal of this project is to perform a systematic review of breath alcohol ignition interlock devices (BAIID or IID) to understand how other states have integrated such systems into administrative and judicial practice and to make recommendations f...

  1. Breath Alcohol Ignition Interlock Devices : Policy and Implementing Implications [SD .MP4 (640x424/29.97fps/22.6MB)

    Science.gov (United States)

    2011-01-01

    The goal of this project is to perform a systematic review of breath alcohol ignition interlock devices (BAIID or IID) to understand how other states have integrated such systems into administrative and judicial practice and to make recommendations f...

  2. [Effect of interlocking intramedullary nail in treatment of open tibial and fibula fractures].

    Science.gov (United States)

    Ji, Jianfei; Zhao, Yinsong; He, Xueyu; Zhou, Yang

    2009-03-01

    To determine the effect of interlocking intramedullary nail in treatment of open tibial and fibula fractures and analyze the method to promote the bone union. From December 2003 to June 2006, thirty-five patients with open tibial and fibula fracture were treated with emergency debridement, interlocked intramedullary fixation for tibia and fixed fibula at the same time. During operation, the bone marrow was collected and grafted into the fracture gaps. Among them, there were 27 males and 8 females, involving in 22 left legs and 13 right legs. Their ages ranged from 19 to 65 years, with an average of 34.7 years. The location of fracture was the middle of the tibia and fibula in 16 cases, the distal 1/3 of the tibia and fibula in 12 cases and the proximal 1/3 in 7 cases. According to the Gustilo classification of open injuries, there were 7 cases of type I, 19 cases of type II, 8 cases of type III a and 1 case of type III b. The mean range of knee motion was 48.3 degrees (45-70 degrees). The mean time from injury to operation was 4.3 hours (50 minutes to 7 hours). The mean operation time was 94 minutes (60-132 minutes) and the mean blood loss was 122 mL (100-350 mL). The wound healed by first intention in 32 patients. Incision was sutured in 2 cases of type III a fractures after operation 4 days, gastrocnemius flap graft was performed in 1 case of type III b fracture 1 week after operation. They all achieve good healing. No fractures split off, no iatrogenic nerve and vascular injury occurred, no osteofascial compartment syndromes or deep vein thrombus happened. Tension blisters appeared in 1 case of type II fracture after operation and subsided after 5 days. Patients were followed up for 14-43 months (mean 22 months). The X-ray films showed that fracture union was observe in 30 cases after 14 weeks of operation, in 3 cases after 18 weeks and in 1 case after 22 weeks of operation. The fractures union time was 15.2 weeks on average. About 2 cm nonunion in lateral

  3. Comparative multicenter study of treatment of multi-fragmented tibial diaphyseal fractures with nonreamed interlocking nails and with bridging plates.

    Science.gov (United States)

    Fernandes, Hélio Jorge Alvachian; Sakaki, Marcos Hideyo; Silva, Jorge dos Santos; dos Reis, Fernando Baldy; Zumiotti, Arnaldo Valdir

    2006-08-01

    A prospective, randomized study to compare patients with closed, multi-fragmented tibial diaphyseal fractures treated using one of two fixation methods undertaken during minimally invasive surgery: nonreamed interlocking intramedullary nails or bridging plates. Forty-five patients were studied; 22 patients were treated with bridging plates, 23 with interlocking nails without reaming. All fractures were Type B and C (according to the AO classification). Clinical and radiographic healing occurred in all cases. No cases of infection occurred. The healing time for patients who received nails was longer (4.32 weeks on average) than the healing time for those who received plates (P = 0.026). No significant differences were observed between the two methods regarding ankle mobility for patients in the two groups. The healing time was shorter with the bridging plate technique, although no significant functional differences were found.

  4. Metal-organic and supramolecular architectures based on mechanically interlocked molecules

    Science.gov (United States)

    Fernando, Isurika Rosini

    The focus of this work is on mechanically interlocked molecules (MIMs), which have unusual physicochemical and mechanical properties with potential applications in nano-scale/molecular devices and high strength materials. Rotaxanes, for example, consist of an axle-like molecule threaded through a wheel-like molecule, with bulky groups at the two ends of the axle preventing the wheel from dissociating. The position of the wheel along the axle can be switched in a controllable and reversible manner by applying external stimuli, a feature that might lead to the next generation of computers. Molecularly woven materials (MWMs), another example of molecules with mechanically interlocked features, are predicted to be unprecedentedly strong while being lightweight and flexible. With the ultimate goal of achieving control over the functioning of molecular devices in the solid state, a variety of pseudorotaxane building blocks were prepared and characterized, including a novel, rare blue-colored motif. The temperature-dependent assembly/disassembly of pseudorotaxanes was exploited for the construction of single-wavelength colorimetric temperature sensors over a 100 °C window. Pseudorotaxanes based on aromatic crown ether wheels and disubstituted 4,4'-bipyridinium axles were converted into rotaxanes upon binding to metal complexes (zinc, cadmium, mercury, copper, cobalt), and the formation of ordered crystalline arrays was studied in the solid state. The columnar organization of pseudorotaxanes by Hg2X6 2-- complexes (X = Cl, Br, I), leading to unprecedented dichroic (blue/red) rotaxane crystals, was demonstrated for the first time. From the crystal structures studied it became apparent that negatively charged metal complexes are needed for successful assembly with the positively charged pseudorotaxane units. To be able to use the more common, positively charged metal ions for rotaxane framework construction, neutral and negatively charged pseudorotaxanes were synthesized

  5. Ground-state thermodynamics of bistable redox-active donor-acceptor mechanically interlocked molecules.

    Science.gov (United States)

    Fahrenbach, Albert C; Bruns, Carson J; Cao, Dennis; Stoddart, J Fraser

    2012-09-18

    Fashioned through billions of years of evolution, biological molecular machines, such as ATP synthase, myosin, and kinesin, use the intricate relative motions of their components to drive some of life's most essential processes. Having control over the motions in molecules is imperative for life to function, and many chemists have designed, synthesized, and investigated artificial molecular systems that also express controllable motions within molecules. Using bistable mechanically interlocked molecules (MIMs), based on donor-acceptor recognition motifs, we have sought to imitate the sophisticated nanoscale machines present in living systems. In this Account, we analyze the thermodynamic characteristics of a series of redox-switchable [2]rotaxanes and [2]catenanes. Control and understanding of the relative intramolecular movements of components in MIMs have been vital in the development of a variety of applications of these compounds ranging from molecular electronic devices to drug delivery systems. These bistable donor-acceptor MIMs undergo redox-activated switching between two isomeric states. Under ambient conditions, the dominant translational isomer, the ground-state coconformation (GSCC), is in equilibrium with the less favored translational isomer, the metastable-state coconformation (MSCC). By manipulating the redox state of the recognition site associated with the GSCC, we can stimulate the relative movements of the components in these bistable MIMs. The thermodynamic parameters of model host-guest complexes provide a good starting point to rationalize the ratio of GSCC to MSCC at equilibrium. The bistable [2]rotaxanes show a strong correlation between the relative free energies of model complexes and the ground-state distribution constants (K(GS)). This relationship does not always hold for bistable [2]catenanes, most likely because of the additional steric and electronic constraints present when the two rings are mechanically interlocked with each other

  6. Structure of Viral Aggregates

    Science.gov (United States)

    Barr, Stephen; Luijten, Erik

    2010-03-01

    The aggregation of virus particles is a particular form of colloidal self-assembly, since viruses of a give type are monodisperse and have identical, anisotropic surface charge distributions. In small-angle X-ray scattering experiments, the Qbeta virus was found to organize in different crystal structures in the presence of divalent salt and non-adsorbing polymer. Since a simple isotropic potential cannot explain the occurrence of all observed phases, we employ computer simulations to investigate how the surface charge distribution affects the virus interactions. Using a detailed model of the virus particle, we find an asymmetric ion distribution around the virus which gives rise to the different phases observed.

  7. Topology Engineering of Proteins in Vivo Using Genetically Encoded, Mechanically Interlocking SpyX Modules for Enhanced Stability.

    Science.gov (United States)

    Liu, Dong; Wu, Wen-Hao; Liu, Ya-Jie; Wu, Xia-Ling; Cao, Yang; Song, Bo; Li, Xiaopeng; Zhang, Wen-Bin

    2017-05-24

    Recombinant proteins are traditionally limited to linear configuration. Herein, we report in vivo protein topology engineering using highly efficient, mechanically interlocking SpyX modules named AXB and BXA. SpyX modules are protein domains composed of p53dim (X), SpyTag (A), and SpyCatcher (B). The p53dim guides the intertwining of the two nascent protein chains followed by autocatalytic isopeptide bond formation between SpyTag and SpyCatcher to fulfill the interlocking, leading to a variety of backbone topologies. Direct expression of AXB or BXA produces protein catenanes with distinct ring sizes. Recombinant proteins containing SpyX modules are obtained either as mechanically interlocked obligate dimers if the protein of interest is fused to the N- or C-terminus of SpyX modules, or as star proteins if the protein is fused to both N- and C-termini. As examples, cellular syntheses of dimers of (GB1) 2 (where GB1 stands for immunoglobulin-binding domain B1 of streptococcal protein G) and of four-arm elastin-like star proteins were demonstrated. Comparison of the catenation efficiencies in different constructs reveals that BXA is generally much more effective than AXB, which is rationalized by the arrangement of three domains in space. Mechanical interlocking induces considerable stability enhancement. Both AXB and BXA have a melting point ∼20 °C higher than the linear controls and the BXA catenane has a melting point ~2 °C higher than the cyclic control BX'A. Notably, four-arm elastin-like star proteins demonstrate remarkable tolerance against trypsin digestion. The SpyX modules provide a convenient and versatile approach to construct unconventional protein topologies via the "assembly-reaction" synergy, which opens a new horizon in protein science for stability enhancement and function reinforcement via topology engineering.

  8. A STUDY OF EXCHANGE OF FAILED IMPLANT WITH INTRAMEDULLARY INTERLOCKING NAIL IN FRACTURES OF FEMUR AND TIBIA

    OpenAIRE

    Rapaka; Maheshwar; Gouru

    2015-01-01

    The aim of the fracture treatment is to achieve union with timely functional recovery. Internal fixation with adherence to strict biomechanical principles is often required to achieve this. However, a fixation device may fail to hold a redu ced fracture until union, giving rise to non - union or delayed union with implant failure. The aim of this study was to see the efficacy of exchange of failed implant with an intra - medullary interlocking nail. PATIENTS AND ...

  9. A comparative study of intramedullary interlocking nailing and minimally invasive plate osteosynthesis in extra articular distal tibial fractures

    OpenAIRE

    Arup K Daolagupu; Ashwani Mudgal; Vikash Agarwala; Kaushik K Dutta

    2017-01-01

    Background: Extraarticular distal tibial fractures are among the most challenging fractures encountered by an orthopedician for treatment because of its subcutaneous location, poor blood supply and decreased muscular cover anteriorly, complications such as delayed union, nonunion, wound infection, and wound dehiscence are often seen as a great challenge to the surgeon. Minimally invasive plate osteosynthesis (MIPO) and intramedullary interlocking nail (IMLN) are two well-accepted and effectiv...

  10. A comparative study of intramedullary interlocking nailing and minimally invasive plate osteosynthesis in extra articular distal tibial fractures.

    Science.gov (United States)

    Daolagupu, Arup K; Mudgal, Ashwani; Agarwala, Vikash; Dutta, Kaushik K

    2017-01-01

    Extraarticular distal tibial fractures are among the most challenging fractures encountered by an orthopedician for treatment because of its subcutaneous location, poor blood supply and decreased muscular cover anteriorly, complications such as delayed union, nonunion, wound infection, and wound dehiscence are often seen as a great challenge to the surgeon. Minimally invasive plate osteosynthesis (MIPO) and intramedullary interlocking nail (IMLN) are two well-accepted and effective methods, but each has been historically related to complications. This study compares clinical and radiological outcome in extraarticular distal tibia fractures treated by intramedullary interlocking nail (IMLN) and minimally invasive plate osteosynthesis (MIPO). 42 patients included in this study, 21 underwent IMLN and 21 were treated with MIPO who met the inclusion criteria and operated between June 2014 and May 2015. Patients were followed up for clinical and radiological evaluation. In IMLN group, average union time was 18.26 weeks compared to 21.70 weeks in plating group which was significant ( P plating group. Lesser complications in terms of implant irritation, ankle stiffness, and infection, were seen in interlocking group as compared to plating group. Average functional outcome according to American Orthopedic Foot and Ankle Society score was measured which came out to be 96.67. IMLN group was associated with lesser duration of surgery, earlier weight bearing and union rate, lesser incidence of infection and implant irritation which makes it a preferable choice for fixation of extra-articular distal tibial fractures. However, larger randomized controlled trials are required for confirming the results.

  11. Taurine and platelet aggregation

    International Nuclear Information System (INIS)

    Nauss-Karol, C.; VanderWende, C.; Gaut, Z.N.

    1986-01-01

    Taurine is a putative neurotransmitter or neuromodulator. The endogenous taurine concentration in human platelets, determined by amino acid analysis, is 15 μM/g. In spite of this high level, taurine is actively accumulated. Uptake is saturable, Na + and temperature dependent, and suppressed by metabolic inhibitors, structural analogues, and several classes of centrally active substances. High, medium and low affinity transport processes have been characterized, and the platelet may represent a model system for taurine transport in the CNS. When platelets were incubated with 14 C-taurine for 30 minutes, then resuspended in fresh medium and reincubated for one hour, essentially all of the taurine was retained within the cells. Taurine, at concentrations ranging from 10-1000 μM, had no effect on platelet aggregation induced by ADP or epinephrine. However, taurine may have a role in platelet aggregation since 35-39% of the taurine taken up by human platelets appears to be secreted during the release reaction induced by low concentrations of either epinephrine or ADP, respectively. This release phenomenon would imply that part of the taurine taken up is stored directly in the dense bodies of the platelet

  12. Biocalcification using Ureolytic Bacteria (UB) for strengthening Interlocking Compressed Earth Blocks (ICEB)

    Science.gov (United States)

    Zamer, M. M.; Irwan, J. M.; Othman, N.; Faisal, S. K.; Anneza, L. H.; Alshalif, A. F.; Teddy, T.

    2018-02-01

    Interlocking compressed earth blocks (ICEB) are soil based blocks that allows for mortarless construction. This characteristic resulted to faster the process of building walls and required less skilled labor as the blocks are laid dry and lock into place. Recently, implementation in using bacteria as construction material improvement is vigorously used in research in order pursuit the sustainable construction works. This paper provide the results of ureolytic bacteria (UB) throughout enrichment process in soil condition to acclimatize the ICEB environment, compressive strength of 1%, 3% and 5% UB and SEM analysis of ICEB. The bacteria were added as partial replacement of limestone water in ICEB. The results showed the optimal growth achieved based on the days and absorbance from optical density (OD) test which are in 12th days with absorbance of 0.55 whereas the results for strength shows the increment of 15.25% with 5% UB on 28th days of testing compared to control specimen. Therefore this study hopes that positive results from the UB as improving in strength of ICEB which will lead to improve others ICEB properties and others construction materials.

  13. Laboratory analysis of the infiltration capacity of interlocking concrete block pavements in car parks.

    Science.gov (United States)

    Sañudo-Fontaneda, Luis A; Rodriguez-Hernandez, Jorge; Vega-Zamanillo, Angel; Castro-Fresno, Daniel

    2013-01-01

    Interlocking concrete block pavements (ICBPs) have been widely used in car parks to reduce runoff. Researches have demonstrated that clogging is the most influential factor in the reduction of the infiltration capacity of this type of permeable pavement. Nevertheless, there is no laboratory study of the infiltration performance of ICBPs that combines clogging levels with variables related with the topography of car parks such as runoff surface length (R(SL)) and surface slope (S(S)). This paper studies the infiltration behaviour of ICBP during their operational life in a car park using an improved version of the Cantabrian Fixed (CF) Infiltrometer. This laboratory device simulates direct rainfall and runoff from adjacent impervious areas over an ICBPs surface of 0.25 m(2) for different slopes (0, 3, 5, 7 and 10%) and three scenarios of clogging (surface newly built, surface clogged and surface clogged with maintenance). This paper presents the results of the tests and a statistical analysis based on three regression models (corresponding to each clogging scenario) depending on the R(SL) and S(S) variables. All models passed a confidence level of 95%, presenting high R(2) values and showing that R(SL) is a more influential variable than the S(S) for all clogging scenarios.

  14. A Simple Field Test to Evaluate the Maintenance Requirements of Permeable Interlocking Concrete Pavements

    Directory of Open Access Journals (Sweden)

    Terry Lucke

    2015-05-01

    Full Text Available Adequate infiltration through Permeable Interlocking Concrete Pavements (PICPs is critical to their hydraulic and stormwater treatment performance. Infiltration is affected by clogging caused by the trapping of fines in the PICP surface, which, over time, reduces treatment performance. Clogging can be reduced by periodic maintenance such as vacuum sweeping and/or pressure washing. Maintenance requirements can be indicated by measuring reduced infiltration rates. This paper compared infiltration results using the standard test (C1781M-14a with the results of a new stormwater infiltration field test (SWIFT developed in Australia to evaluate the maintenance requirements of PICPs. A strong correlation (Pearson’s r = −0.714 was found between results using the two methods. This study found that the SWIFT was a reliable method for estimating the degree of clogging of PICPs while successfully overcoming some of the problems with the more technical existing test methodology such as horizontal water leakage (use of sealant, unrealistic pressure heads, speed of test, and portability. The SWIFT test is a simple, fast and inexpensive way for asset managers and local government employees to quickly assess the maintenance requirements of PICP installations in the field.

  15. Comparing Two Methods of Determining Infiltration Rates of Permeable Interlocking Concrete Pavers

    Directory of Open Access Journals (Sweden)

    Peter W.B.Nichols

    2014-08-01

    Full Text Available Adequate infiltration through Permeable Interlocking Concrete Pavements (PICPs is critical to their hydraulic performance. Detected by monitoring infiltration performance, reduced infiltration rates can indicate that maintenance is required. Measurement of infiltration rates has previously been problematic on PICPs because of a lack of accepted standard methodologies and the practical difficulties in modifying existing testing methodologies. On large sites, standard methodologies necessitate multiple measurements to achieve accuracy. Standard methods also contend with practical issues such as sealing the rings to the surface to prevent lateral water flow. This study examined the performance of two PICP surface infiltration rate measurement methods: a modified double-ring infiltrometer (DRIT, and a specially designed rainfall simulation infiltrometer (RSIT. A positive correlation (R2 = 0.85 of results was found between the two, demonstrating that the RSIT was comparable to the DRIT. The modified DRIT produced surface infiltration results approximately 60% higher than the RSIT results. The RSIT provided lower variation between tests, requiring fewer measurements in large sites whilst still maintaining accuracy, thereby improving testing efficiency. The new RSIT method also eliminates some of the practical difficulties with existing methodologies such as unrealistic pressure heads artificially increasing infiltration rates, and the use of sealant under test measurement infiltration rings.

  16. Removal of interlocking intramedullary nail for relieve of knee pain after tibial fracture repair.

    Science.gov (United States)

    Zhang, Shaodong; Wu, Xiaotao; Liu, Lei; Wang, Chen

    2017-01-01

    To investigate the effects of intramedullary nail removal after tibial fracture repair. Sixty patients at our hospital were enrolled in a prospective study and divided into moderate/severe knee pain (visual analog scale (VAS) ≥ 4) and mild/no knee pain (VAS knee and ankle pain, the range of motion of the knee and ankle, and Johner-Wruhs criteria before, 6 weeks after operation, and at the last follow-up. Fifty-seven patients were followed for a mean of 8.4 (2-17) months. In patients with moderate or severe knee pain intramedullary nail removal led to significant pain reductions ( p anterior border of tibia (knee pain. Knee pain VAS scores significantly lowered 6 weeks postoperatively and at the last follow-up, compared to before the operation ( p pain VAS scores, range of motion, and Johner-Wruhs criteria ( p > 0.05). For patients complaining knee pain after interlocking intramedullary nailing of tibial fractures, especially with a short distance from the tip of the nail tail to the tibial plateau (anterior border of the tibia (pain significantly.

  17. Active interlock system for high power insertion devices in the x-ray ring

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    In modern synchrotron radiation rings photon beams generated by high power insertion devices (IDs) may be sufficiently intense to cause severe thermal damage to the machine vacuum chamber if mis-steered. Thus when operating a storage ring with the IDs, great care must be exercised to prevent mis-steering of the electron beam orbit. At present, the X-ray ring operates with three IDs, namely two hybrid wigglers (HBW) at X-21 and X-25,a nd a 5-Tesla superconducting wiggler at X-17. All wigglers are located in low-beta straight sections. In the straight sections. In the straight sections, beam orbit may be deflected by as much as ±8 mrad without scraping the chamber wall. For various reasons it was not possible to design the X-ray ring vacuum chamber to be safe under all possible operating conditions, however, the chamber is safe for i < 7 mA, all horizontal beam deflection angles and for vertical angles < ± 2.5 mrad. To protect the machine vacuum chamber from damage due to mis-steered beams, and interlock system has been developed and installed. This system utilizes active beam position detectors which continuously monitor beam motion in each of the ID straight sections and logic circuitry which interrupts the RF and dumps the stored beam in the case of a fault

  18. Being present in action: a theoretical model about the interlocking between intentions and environmental affordances

    Directory of Open Access Journals (Sweden)

    Stefano eTriberti

    2016-01-01

    Full Text Available Recent neuropsychological evidence suggest that a key role in linking perceptions and intentions is played by sense of presence. Despite this phenomenon having been studied primarily in the field of virtual reality (conceived as the illusion of being in the virtual space, recent research highlighted that it is a fundamental feature of everyday experience. Specifically, the function of presence as a cognitive process is to locate the Self in a physical space or situation, based on the perceived possibility to act in it; so, the variations in sense of presence allow one to continuously adapt his own action to the external environment. Indeed intentions, as the cognitive antecedents of action, are not static representations of the desired outcomes, but dynamic processes able to adjust their own representational content according to the opportunities/restrictions emerging in the environment. Focusing on the peculiar context of action mediated by interactive technologies, we here propose a theoretical model showing how each level of an intentional hierarchy (future-directed; present directed; and motor intentions can interlock with environmental affordances in order to promote a continuous stream of action and activity.

  19. Hindfoot Valgus following Interlocking Nail Treatment for Tibial Diaphysis Fractures: Can the Fibula Be Neglected?

    Directory of Open Access Journals (Sweden)

    Metin Uzun

    2014-01-01

    Full Text Available Purpose. We evaluated whether intramedullary nail fixation for tibial diaphysis fractures with concomitant fibula fractures (except at the distal one-third level managed conservatively with an associated fibula fracture resulted in ankle deformity and assessed the impact of the ankle deformity on lower extremity function. Methods. Sixty middle one-third tibial shaft fractures with associated fibular fractures, except the distal one-third level, were included in this study. All tibial shaft fractures were anatomically reduced and fixed with interlocking intramedullary nails. Fibular fractures were managed conservatively. Hindfoot alignment was assessed clinically. Tibia and fibular lengths were compared to contralateral measurements using radiographs. Functional results were evaluated using the Knee Injury and Osteoarthritis Outcome Score (KOOS and the Foot and Ankle Disability Index Score (FADI. Results. Anatomic union, defined as equal length in operative and contralateral tibias, was achieved in 60 fractures (100%. Fibular shortening was identified in 42 fractures (68%. Mean fibular shortening was 1.2 cm (range, 0.5–2 cm. Clinical exams showed increased hindfoot valgus in 42 fractures (68%. The mean KOOS was 88.4, and the mean FADI score was 90. Conclusion. Fibular fractures in the middle or proximal one-third may need to be stabilized at the time of tibial intramedullary nail fixation to prevent development of hindfoot valgus due to fibular shortening.

  20. Being Present in Action: A Theoretical Model About the "Interlocking" Between Intentions and Environmental Affordances.

    Science.gov (United States)

    Triberti, Stefano; Riva, Giuseppe

    2015-01-01

    Recent neuropsychological evidence suggest that a key role in linking perceptions and intentions is played by sense of presence. Despite this phenomenon having been studied primarily in the field of virtual reality (conceived as the illusion of being in the virtual space), recent research highlighted that it is a fundamental feature of everyday experience. Specifically, the function of presence as a cognitive process is to locate the Self in a physical space or situation, based on the perceived possibility to act in it; so, the variations in sense of presence allow one to continuously adapt his own action to the external environment. Indeed intentions, as the cognitive antecedents of action, are not static representations of the desired outcomes, but dynamic processes able to adjust their own representational content according to the opportunities/restrictions emerging in the environment. Focusing on the peculiar context of action mediated by interactive technologies, we here propose a theoretical model showing how each level of an intentional hierarchy (future-directed; present directed; and motor intentions) can "interlock" with environmental affordances in order to promote a continuous stream of action and activity.

  1. A bio-inspired swellable microneedle adhesive for mechanical interlocking with tissue

    Science.gov (United States)

    Yang, Seung Yun; O'Cearbhaill, Eoin D.; Sisk, Geoffroy C.; Park, Kyeng Min; Cho, Woo Kyung; Villiger, Martin; Bouma, Brett E.; Pomahac, Bohdan; Karp, Jeffrey M.

    2013-04-01

    Achieving significant adhesion to soft tissues while minimizing tissue damage poses a considerable clinical challenge. Chemical-based adhesives require tissue-specific reactive chemistry, typically inducing a significant inflammatory response. Staples are fraught with limitations including high-localized tissue stress and increased risk of infection, and nerve and blood vessel damage. Here inspired by the endoparasite Pomphorhynchus laevis, which swells its proboscis to attach to its host’s intestinal wall, we have developed a biphasic microneedle array that mechanically interlocks with tissue through swellable microneedle tips, achieving ~3.5-fold increase in adhesion strength compared with staples in skin graft fixation, and removal force of ~4.5 N cm-2 from intestinal mucosal tissue. Comprising a poly(styrene)-block-poly(acrylic acid) swellable tip and non-swellable polystyrene core, conical microneedles penetrate tissue with minimal insertion force and depth, yet high adhesion strength in their swollen state. Uniquely, this design provides universal soft tissue adhesion with minimal damage, less traumatic removal, reduced risk of infection and delivery of bioactive therapeutics.

  2. String Electron and Three-ring Quarked Nucleons' Transverse Interlocks Build Atoms, Vindicate Schr"odinger

    Science.gov (United States)

    McLeod, David; McLeod, Roger David

    2008-05-01

    Flatland electron loop strings have transversely vibrating neutrino strings. Traveling waves TWs alternately become upwardly deflecting standing waves SWs along each half-wave segment between non-vibrating node pairs. Descending SWs revert to TWs at flatland, proceeding to the next adjacent nodal pair; folding continues. New SWs descend, then ascend; repetition follows to a three dimensional object. Broken ``linear'' electron string and spring constant compress within stars so linear mass density allows incorporation into stable three-ring proton string, creating neutron of two down quarks, one up. It is unstable; it lacks overpass-underpass interlocks of proton that merged linear charge density of two up quarks and one down quark with the electron, becoming neutral. Any transversely aligned neutron notch pushed into acceptor notch of proton is ionized deuterium; tritium follows. Alpha particle is a stable ``tic-tac-toe'' grid. Atom building proceeds routinely, nucleon attachment follows chemical and physical property requirements. Models require vindication of Schr"odinger's actual, but incomplete, wave model of electron with physical extent over his wave, and question Heisenberg's uncertainty proposal.

  3. The Tight-interlocked Rhythm Section: Production and Perception of Synchronisation in Jazz Trio Performance.

    Science.gov (United States)

    Hofmann, Alex; Wesolowski, Brian C; Goebl, Werner

    2017-01-01

    This study investigates the production and perception of timing, synchronisation and dynamics in jazz trio performances. In a production experiment, six trio combinations of one saxophonist, two bassists, and three drummers were recorded while they performed three popular jazz songs. Onset timing and dynamics of each performer were extracted and analysed. Results showed that the tempo was significantly influenced by the timing of the drummers and all performers showed higher temporal precision on the backbeats. The drummers demonstrated individual swing-ratios, accentuations of beats and intrapersonal asynchronies between simultaneous hi-hat and ride cymbal onsets, which resulted in a hi-hat played 2-26 ms ahead of the pulse of the music. In a subsequent perception test, participants ([Formula: see text]) rated 12 excerpts of the jazz recordings. They selected their preferred version from a pool of stimuli containing the original version, but also manipulations with artificially increased or reduced asynchronies. Stimuli with reduced asynchronies smaller than 19 ms were preferred by the listeners over the original or the fully quantised timing. This suggests that listeners endorse a 'tight-interlocked' jazz rhythm section, with asynchronies smaller than the perceptual threshold (temporal masking), but with natural timing variabilities that makes it distinguishable from a computer-generated playback.

  4. Development of Remote Control and Interlock System for the PEFP Microwave Ion Source

    International Nuclear Information System (INIS)

    Song, Young Gi; Seol, Kyung Tae; Kwon, Hyeok Jung; Jang, Ji Ho; Cho, Yong Sub

    2011-01-01

    The control system for a microwave ion source as an isolated high voltage device is a main part of the PEFP distributed control system. The system is used to control two sets of microwave ion sources, the remote control and the interlock system. A VME system with an embedded Power PC CPU is used as main computer. The VME system is dedicated to control and monitoring of the ion source operation. An isolated control system has been designed and developed for remote control and monitoring of a microwave generator and various power supplies. As the source is placed on high voltage platform, optical fiber isolation has been used between the serial to optical fiber VME I/O board and the control system on the high voltage platform. These are connected through RS232 serial interface. A fast Ethernet is used to communicate between the microwave ion source control system and other control stations in the PEFP control system. EPICS toolkit is adopted to provide network programming and user interface by using EPICS Channel Access (CA)

  5. A Bio-Inspired Swellable Microneedle Adhesive for Mechanical Interlocking with Tissue

    Science.gov (United States)

    Yang, Seung Yun; O'Cearbhaill, Eoin D.; Sisk, Geoffroy C.; Park, Kyeng Min; Cho, Woo Kyung; Villiger, Martin; Bouma, Brett E.; Pomahac, Bohdan; Karp, Jeffrey M.

    2013-01-01

    Achieving significant adhesion to soft tissues while minimizing tissue damage poses a considerable clinical challenge. Chemical-based adhesives require tissue-specific reactive chemistry, typically inducing a significant inflammatory response. Staples are fraught with limitations including high-localized tissue stress and increased risk of infection, and nerve and blood vessel damage. Here, inspired by the endoparasite Pomphorhynchus laevis which swells its proboscis to attach to its host’s intestinal wall, we have developed a biphasic microneedle array that mechanically interlocks with tissue through swellable microneedle tips, achieving ~ 3.5 fold increase in adhesion strength compared to staples in skin graft fixation, and removal force of ~ 4.5 N/cm2 from intestinal mucosal tissue. Comprising a poly(styrene)-block-poly(acrylic acid) swellable tip and non-swellable polystyrene core, conical microneedles penetrate tissue with minimal insertion force and depth, yet high adhesion strength in their swollen state. Uniquely, this design provides universal soft tissue adhesion with minimal damage, less traumatic removal, reduced risk of infection and delivery of bioactive therapeutics. PMID:23591869

  6. Fatigue behavior of Ilizarov frame versus tibial interlocking nail in a comminuted tibial fracture model: a biomechanical study

    Directory of Open Access Journals (Sweden)

    Stahel Philip F

    2006-12-01

    Full Text Available Abstract Background Treatment options for comminuted tibial shaft fractures include plating, intramedullary nailing, and external fixation. No biomechanical comparison between an interlocking tibia nail with external fixation by an Ilizarov frame has been reported to date. In the present study, we compared the fatigue behaviour of Ilizarov frames to interlocking intramedullary nails in a comminuted tibial fracture model under a combined loading of axial compression, bending and torsion. Our goal was to determine the biomechanical characteristics, stability and durability for each device over a clinically relevant three month testing period. The study hypothesis was that differences in the mechanical properties may account for differing clinical results and provide information applicable to clinical decision making for comminuted tibia shaft fractures. Methods In this biomechanical study, 12 composite tibial bone models with a comminuted fracture and a 25 mm diaphyseal gap were investigated. Of these, six models were stabilized with a 180-mm four-ring Ilizarov frame, and six models were minimally reamed and stabilized with a 10 mm statically locked Russell-Taylor Delta™ tibial nail. After measuring the pre-fatigue axial compression bending and torsion stiffness, each model was loaded under a sinusoidal cyclic combined loading of axial compression (2.8/28 lbf; 12.46/124.6 N and torque (1.7/17 lbf-in; 0.19/1.92 Nm at a frequency of 3 Hz. The test was performed until failure (implant breakage or ≥ 5° angulations and/or 2 cm shortening occurred or until 252,000 cycles were completed, which corresponds to approximately three months testing period. Results In all 12 models, both the Ilizarov frame and the interlocking tibia nail were able to maintain fracture stability of the tibial defect and to complete the full 252,000 cycles during the entire study period of three months. A significantly higher stiffness to axial compression and torsion was

  7. Proteins aggregation and human diseases

    International Nuclear Information System (INIS)

    Hu, Chin-Kun

    2015-01-01

    Many human diseases and the death of most supercentenarians are related to protein aggregation. Neurodegenerative diseases include Alzheimer's disease (AD), Huntington's disease (HD), Parkinson's disease (PD), frontotemporallobar degeneration, etc. Such diseases are due to progressive loss of structure or function of neurons caused by protein aggregation. For example, AD is considered to be related to aggregation of Aβ40 (peptide with 40 amino acids) and Aβ42 (peptide with 42 amino acids) and HD is considered to be related to aggregation of polyQ (polyglutamine) peptides. In this paper, we briefly review our recent discovery of key factors for protein aggregation. We used a lattice model to study the aggregation rates of proteins and found that the probability for a protein sequence to appear in the conformation of the aggregated state can be used to determine the temperature at which proteins can aggregate most quickly. We used molecular dynamics and simple models of polymer chains to study relaxation and aggregation of proteins under various conditions and found that when the bending-angle dependent and torsion-angle dependent interactions are zero or very small, then protein chains tend to aggregate at lower temperatures. All atom models were used to identify a key peptide chain for the aggregation of insulin chains and to find that two polyQ chains prefer anti-parallel conformation. It is pointed out that in many cases, protein aggregation does not result from protein mis-folding. A potential drug from Chinese medicine was found for Alzheimer's disease. (paper)

  8. Novel aspects of platelet aggregation

    Directory of Open Access Journals (Sweden)

    Roka-Moya Y. M.

    2014-01-01

    Full Text Available The platelet aggregation is an important process, which is critical for the hemostatic plug formation and thrombosis. Recent studies have shown that the platelet aggregation is more complex and dynamic than it was previously thought. There are several mechanisms that can initiate the platelet aggregation and each of them operates under specific conditions in vivo. At the same time, the influence of certain plasma proteins on this process should be considered. This review intends to summarize the recent data concerning the adhesive molecules and their receptors, which provide the platelet aggregation under different conditions.

  9. Aggregating energy flexibilities under constraints

    DEFF Research Database (Denmark)

    Valsomatzis, Emmanouil; Pedersen, Torben Bach; Abello, Alberto

    2016-01-01

    The flexibility of individual energy prosumers (producers and/or consumers) has drawn a lot of attention in recent years. Aggregation of such flexibilities provides prosumers with the opportunity to directly participate in the energy market and at the same time reduces the complexity of scheduling...... and amount dimensions. We define the problem of aggregating FOs taking into account grid power constraints. We also propose two constraint-based aggregation techniques that efficiently aggregate FOs while retaining flexibility. We show through a comprehensive evaluation that our techniques, in contrast...

  10. Design and Properties of Thin Surfacing Hot Mix Asphalt Containing Crumb Rubber as Partial Aggregate Replacement

    Science.gov (United States)

    Setyawan, Ary; Febrianto, Nugroho; Sarwono, Djoko

    2017-07-01

    Road damage caused as a result of the traffic load and environment. One method to improve the road condition is from an overlay. But the new layer on the top of the pavement structure is thick enough and elevate the surface of the pavement, so it will cause some impact on the user safety and engineering. The use of a thin layer of hot mix asphalt is an alternative to anticipate the thickness problem. Crumb rubber is a waste material that has a flexible nature, these materials are used as an aggregate replacement in the hot mix asphalt thin layer. The research was conducted to find the optimum bitumen content and optimum crumb rubber content on asphalt mixtures by the Marshall procedure. Finally, it was concluded that the addition of crumb rubber in a thin layer of hot mix asphalt indicates the better the interlocking between aggregates so that gave the better Marshall stability, the higher the flow rate, the lower the marshall quotient, reduce the void ratio. The results show that the addition of crumb rubber content as an aggregate replacement leads to the use of less optimum bitumen content.

  11. Early Clinical Experience with a Newly Designed Interlocking Nail System-Targon(®) Vet.

    Science.gov (United States)

    Brückner, Michael; Unger, Martin; Spies, Markus

    2016-08-01

    To describe early clinical experience with a newly designed interlocking nail system (Targon(®) Vet) in diaphyseal fractures in cats and small dogs. Retrospective case series. Client-owned cats (n=49) and dogs (n=8). Fifty-seven consecutive cases (49 cats, 8 dogs) with 60 long bone fractures were included in the study. Follow-up radiographs were scheduled at 4 and 8 weeks and again 6 months postoperatively. The end point for each case was determined radiographically by a healed fracture. Complications were defined as minor or major. Clinical outcome was subjectively assessed by a full orthopedic examination and follow-up radiographs. Descriptive data are reported. Median age of cats was 18 months (range, 3-220 months) and of dogs was 28 months (range, 7-115 months). Median body weight was 3.7 kg (range, 1.67-8.41 kg) for cats and 8.15 kg (range, 2.68-13.6 kg) for dogs. Median radiographic follow-up was 16 weeks. All fractures with follow-up radiographs available (n=46) were healed with no infections reported. A total of 12 postoperative complications occurred: 3 minor (slippage of the locking screws) and 9 major (5 femoral-irritation of the sciatic nerve, stress protection, fracture because of a missed fissure, femoral neck fracture, intra-operative revision with a rod and plate; 4 tibial-3 with protrusion of the distal locking screw through the skin and 1 with in-growth of the intramedullary nail). Implantation of the Targon(®) Vet System was feasible in all cases. It provides an alternative system for diaphyseal fracture repair in cats and small dogs. © Copyright 2016 by The American College of Veterinary Surgeons.

  12. Elaboration of the configuration and programming of the interlocks system of the TRIGA Mark III reactor

    International Nuclear Information System (INIS)

    Mejia C, M. A.

    2016-01-01

    The modernization of the TRIGA Mark III reactor interlock system requires a system that provides high reliability, flexibility and ease of operation during reactor operation. With this modernization of the system, is intended to prevent, control and mitigate the causes of probable accidents reported in the reactor accident analysis. On the other hand, is foreseen the ease reactor operation in a simple, safe and efficient way. The programmable logic controller can be programmed by programming instructions using simple language and easy to develop, these can be modified from a computer using the programming software. In addition, another of the advantages offered by the controller is that can be modified from a touch screen (human-machine interface) that allows adjustment, without the need to use programming software and diagnostic functions during the process. As a result of the present work, a situation of improvement in the reactor operation was generated, facilitating the handling of the bridge and increasing the efficiency of the system in the execution of the operating conditions of the installations external to the reactor. A modern, more reliable and much less expensive system was achieved than the previous one, avoiding that the maintenance to the system generates high expenses. With respect to the development of the application programming, a control was implemented that allows to select a zone of the five that have inside the pool to carry out the displacement of automatic way and later to be located in that zone, having in this way a greater efficiency and ease in bridge control. (Author)

  13. Ca2+-sensors and ROS-GC: Interlocked sensory transduction elements: A review

    Directory of Open Access Journals (Sweden)

    Rameshwar K Sharma

    2012-04-01

    Full Text Available From its initial discovery that ROS-GC membrane guanylate cyclase is a mono-modal Ca2+-transduction system linked exclusively with the phototransduction machinery to the successive finding that it embodies a remarkable bimodal Ca2+signaling device, its widened transduction role in the general signaling mechanisms of the sensory neuron cells was envisioned. A theoretical concept was proposed where Ca2+-modulates ROS-GC through its generated cyclic GMP via a nearby cyclic nucleotide gated channel and creates a hyper- or depolarized sate in the neuron membrane (Ca2+ Binding Proteins 1:1, 7-11, 2006. The generated electric potential then becomes a mode of transmission of the parent [Ca2+]i signal. Ca2+ and ROS-GC are interlocked messengers in multiple sensory transduction mechanisms.This comprehensive review discusses the developmental stages to the present status of this concept and demonstrates how neuronal Ca2+-sensor proteins are the interconnected elements of this elegant ROS-GC transduction system. The focus is on the dynamism of the structural composition of this system, and how it accommodates selectivity and elasticity for the Ca2+ signals to perform multiple tasks linked with the SENSES of vision, smell and possibly of taste and the pineal gland. An intriguing illustration is provided for the Ca2+ sensor GCAP1 which displays its remarkable ability for its flexibility in function from being a photoreceptor sensor to an odorant receptor sensor. In doing so it reverses its function from an inhibitor of ROS-GC to the stimulator of ONE-GC membrane guanylate cyclase.

  14. Improved osseointegration and interlocking capacity with dual acid-treated implants: a rabbit study.

    Science.gov (United States)

    Halldin, Anders; Jimbo, Ryo; Johansson, Carina B; Gretzer, Christina; Jacobsson, Magnus

    2016-01-01

    To investigate how osseointegration is affected by different nano- and microstructures. The hypothesis was that the surface structure created by dual acid treatment (AT-1), applied on a reduced topography, might achieve equivalent biomechanical performance as a rougher surface treated with hydrofluoric acid (HF). In a preclinical rabbit study, three groups (I, II, and III) comprised of test and control implants were inserted in 30 rabbits. The microstructures of the test implants were either produced by blasting with coarse (I) or fine (II) titanium particles or remained turned (III). All test implants were thereafter treated with AT-1 resulting in three different test surfaces. The microstructure of the control implants was produced by blasting with coarse titanium particles thereafter treated with HF. The surface topography was characterized by interferometry. Biomechanical (removal torque) and histomorphometric (bone-implant contact; bone area) performances were measured after 4 or 12 weeks of healing. Removal torque measurement demonstrated that test implants in group I had an enhanced biomechanical performance compared to that of the control despite similar surface roughness value (Sa ). At 4 weeks of healing, group II test implants showed equivalent biomechanical performance to that of the control, despite a decreased Sa value. Group III test implants showed decreased biomechanical performance to that of the control. The results of the present study suggest that nano- and microstructure alteration by AT-1 on a blasted implant might enhance the initial biomechanical performance, while for longer healing time, the surface interlocking capacity seems to be more important. © 2014 The Authors. Clinical Oral Implants Research Published by John Wiley & Sons Ltd.

  15. The best location for proximal locking screw for femur interlocking nailing: A biomechanical study.

    Science.gov (United States)

    Karaarslan, Ahmet A; Karakaşli, Ahmet; Aycan, Hakan; Çeçen, Berivan; Yildiz, Didem Venüs; Sesli, Erhan

    2016-01-01

    Proximal locking screw deformation and screw fracture is a frequently seen problem for femur interlocking nailing that affects fracture healing. We realized that there is lack of literature for the right level for the proximal locking screw. We investigated the difference of locking screw bending resistance between the application of screws on different proximal femoral levels. We used a total of 80 proximal locking screws for eight groups, 10 screws for each group. Three-point bending tests were performed on four types of screws in two different trochanteric levels (the lesser trochanter and 20 mm proximal). We determined the yield points at three-point bending tests that a permanent deformation started in the locking screws using an axial compression testing machine. The mean yield point value of 5 mm threaded locking screws applied 20 mm proximal of lesser trochanter was 1022 ± 49 (range 986-1057) (mean ± standard deviation, 95% confidence interval). On the other hand, the mean yield point value of the same type of locking screws applied on the lesser trochanteric level was 2089 ± 249 (range 1911-2268). Which means 103% increase of screw resistance between two levels (P = 0.000). In all screw groups, on the lesser trochanter line we determined 98-174% higher than the yield point values of the same type of locking screws in comparison with 20 mm proximal to the lesser trochanter (P = 0.000). According to our findings, there is twice as much difference in locking screw bending resistance between these two application levels. To avoid proximal locking screw deformation, locking screws should be placed in the level of the lesser trochanter in nailing of 1/3 middle and distal femur fractures.

  16. Topics in Probabilistic Judgment Aggregation

    Science.gov (United States)

    Wang, Guanchun

    2011-01-01

    This dissertation is a compilation of several studies that are united by their relevance to probabilistic judgment aggregation. In the face of complex and uncertain events, panels of judges are frequently consulted to provide probabilistic forecasts, and aggregation of such estimates in groups often yield better results than could have been made…

  17. The Poisson aggregation process

    International Nuclear Information System (INIS)

    Eliazar, Iddo

    2016-01-01

    In this paper we introduce and analyze the Poisson Aggregation Process (PAP): a stochastic model in which a random collection of random balls is stacked over a general metric space. The scattering of the balls’ centers follows a general Poisson process over the metric space, and the balls’ radii are independent and identically distributed random variables governed by a general distribution. For each point of the metric space, the PAP counts the number of balls that are stacked over it. The PAP model is a highly versatile spatial counterpart of the temporal M/G/∞ model in queueing theory. The surface of the moon, scarred by circular meteor-impact craters, exemplifies the PAP model in two dimensions: the PAP counts the number of meteor-impacts that any given moon-surface point sustained. A comprehensive analysis of the PAP is presented, and the closed-form results established include: general statistics, stationary statistics, short-range and long-range dependencies, a Central Limit Theorem, an Extreme Limit Theorem, and fractality.

  18. [Retrograde interlocked intramedullary nailing with tibia bone graft fusion for the treatment of end-stage ankle arthritis].

    Science.gov (United States)

    Hao, Zhong-Yu; Pei, Ping; Liu, Lin; Song, Yu-Xin

    2017-06-25

    To explore clinical outcomes of retrograde interlocked intramedullary nailing with tibia bone graft fusion in treating end-stage ankle arthritis. From November 2014 to April 2016, 22 patients with end-stage ankle arthritis were treated with retrograde interlocked intramedullary nailing with tibia bone graft fusion, including 9 males and 13 females aged from 30 to 65 years old with an average of 48.5 years old. Seven patients had obvious varus deformity, and other 15 patients' appearance were normal. Operative time, blood loss, fracture healing time and complications were observed and compared, AOFAS and VAS score were applied for evaluate ankle joint function and pain degree before operation and 9 months after operation. All patients were followed up from 12 to 24 months with an average of 18.6 months. The incision were healed at stage I , and no complications occurred. Operative time ranged from 80 to 120 min with an average of 90 min;blood loss ranged from 15 to 50 ml with an average of 30 ml;fracture healing time was from 10 to 18 weeks with an average of 14 weeks. AOFAS score at 9 months after operation was 88.00±3.45, while 54.82±2.98 before operation, and there was statistical significance; 8 cases obtained excellent results, 12 good and 2 moderate. There was significant difference in VAS score between preoperative(3.96±1.27) and 9 months after operation(9.37±0.55). Retrograde interlocked intramedullary nailing with tibia bone graft fusion for the treatment of end-stage ankle arthritis has advantages of stable fixation, less trauma, less blood loss, bone union and rapid recovery of function, and could relieve pain obviously.

  19. Definition and means of maintaining the process vacuum liquid detection interlock systems portion of the PFP safety envelope

    International Nuclear Information System (INIS)

    THOMAS, R.J.

    1999-01-01

    The Process Vacuum Liquid Detection interlock systems prevent intrusion of process liquids into the HEPA filters downstream of demisters No.6 and No.7 during Process Vacuum System operation. This prevents liquid intrusion into the filters, which could cause a criticality. The Safety Envelope (SE) includes the equipment, which detects the presence of liquids in the vacuum headers; isolates the filters; shuts down the vacuum pumps; and alarms the condition. This report identifies the equipment in the SE operating, maintenance, and surveillance procedures needed to maintain the SE equipment; and rationale for exclusion of some equipment and testing from the SE

  20. Reamed interlocking intramedullary nailing for the treatment of tibial diaphyseal fractures and aseptic nonunions. Can we expect an optimum result?

    OpenAIRE

    Chalidis, Byron E.; Petsatodis, George E.; Sachinis, Nick C.; Dimitriou, Christos G.; Christodoulou, Anastasios G.

    2009-01-01

    The need for reaming and the number of locking screws to be used in intramedullary (IM) tibial nailing of acute fractures as well as routine bone grafting of tibial aseptic nonunions have not been clearly defined. We describe the results of reamed interlocked IM nails in 233 patients with 247 tibial fractures (190 closed, 27 open and 30 nonunions). Ninety-six percent of the fractures were united at review after an average of 4.9?years. No correlation was found between union and nail diameter ...

  1. Kinetics of aggregation with choice.

    Science.gov (United States)

    Ben-Naim, E; Krapivsky, P L

    2016-12-01

    We generalize the ordinary aggregation process to allow for choice. In ordinary aggregation, two random clusters merge and form a larger aggregate. In our implementation of choice, a target cluster and two candidate clusters are randomly selected and the target cluster merges with the larger of the two candidate clusters. We study the long-time asymptotic behavior and find that as in ordinary aggregation, the size density adheres to the standard scaling form. However, aggregation with choice exhibits a number of different features. First, the density of the smallest clusters exhibits anomalous scaling. Second, both the small-size and the large-size tails of the density are overpopulated, at the expense of the density of moderate-size clusters. We also study the complementary case where the smaller candidate cluster participates in the aggregation process and find an abundance of moderate clusters at the expense of small and large clusters. Additionally, we investigate aggregation processes with choice among multiple candidate clusters and a symmetric implementation where the choice is between two pairs of clusters.

  2. Kinetics of aggregation with choice

    Science.gov (United States)

    Ben-Naim, E.; Krapivsky, P. L.

    2016-12-01

    We generalize the ordinary aggregation process to allow for choice. In ordinary aggregation, two random clusters merge and form a larger aggregate. In our implementation of choice, a target cluster and two candidate clusters are randomly selected and the target cluster merges with the larger of the two candidate clusters. We study the long-time asymptotic behavior and find that as in ordinary aggregation, the size density adheres to the standard scaling form. However, aggregation with choice exhibits a number of different features. First, the density of the smallest clusters exhibits anomalous scaling. Second, both the small-size and the large-size tails of the density are overpopulated, at the expense of the density of moderate-size clusters. We also study the complementary case where the smaller candidate cluster participates in the aggregation process and find an abundance of moderate clusters at the expense of small and large clusters. Additionally, we investigate aggregation processes with choice among multiple candidate clusters and a symmetric implementation where the choice is between two pairs of clusters.

  3. Aggregating and Disaggregating Flexibility Objects

    DEFF Research Database (Denmark)

    Siksnys, Laurynas; Valsomatzis, Emmanouil; Hose, Katja

    2015-01-01

    In many scientific and commercial domains we encounter flexibility objects, i.e., objects with explicit flexibilities in a time and an amount dimension (e.g., energy or product amount). Applications of flexibility objects require novel and efficient techniques capable of handling large amounts...... and aiming at energy balancing during aggregation. In more detail, this paper considers the complete life cycle of flex-objects: aggregation, disaggregation, associated requirements, efficient incremental computation, and balance aggregation techniques. Extensive experiments based on real-world data from...

  4. Interlocking Directorships in Polish Joint Stock Companies = Medsebojna prepletenost članov nadzornih svetov v delniških družbah na Poljskem

    Directory of Open Access Journals (Sweden)

    Marek Pawlak

    2008-09-01

    Full Text Available Studies concerning interlocking directorships have been carried out among Polish joint stock corporations. The main source of data have been the announcements that are to be published by corporations regularly in a journal called Business and Court Gazette (BCG. Interlocking directorships constitute a network among corporations the use of which enables co-ordinated management of the whole group. The phenomenon of interlocking directorships in Polish joint stock companies can be compared to the same phenomenon existing in other countries. About 13.43 percent of Polish joint stock company directors possess additional directorships. The average number of directorships for the whole group employed by Polish joint stock companies is 1,207, and 2,541 for people who hold more than one mandate. There is a positive correlation between the total investments in the Polish economy and the number of multiple directorships.

  5. Guidelines for Collecting Aggregations of Web Resources.

    Science.gov (United States)

    Walters, William H.; Demas, Samuel G.; Stewart, Linda; Weintraub, Jennifer

    1998-01-01

    Presents three criteria (content, coherence, and functionality) for selecting aggregated World Wide Web resources and planning presentations of aggregated resources in library catalogs and Web pages. Ensuring access to aggregated resources is also discussed. (PEN)

  6. Bending and torsional stiffness in cadaver humeri fixed with a self-locking expandable or interlocking nail system: a mechanical study.

    Science.gov (United States)

    Blum, Jochen; Karagül, Göksen; Sternstein, Werner; Rommens, Pol M

    2005-09-01

    This study was designed to gain data about a new expandable, noninterlocked intramedullary nail's capacity to stabilize unstable transverse humeral shaft fractures without the need for interlocking, thus making nail implantation simpler and to prove our goal hypothesis: that in a midshaft osteotomy of the humeral shaft the expandable humeral nail will show the same bending and torsional stiffness as an interlocked humeral nail, when implanted correctly according to the manufacturer's instructions. Pair randomization. Mechanical laboratory testing. Eight pairs of freshly harvested cadaveric humeri. Fracture model was a midshaft transverse osteotomy, gapped to 3 mm. Each humerus pair received an expandable humeral nail (Fixion) or an interlocked humerus nail (Synthes) through a retrograde approach. The humeri were fixed in polymethylmethacrylate cylinders and tested in a servo-pneumatic material-testing machine. Torsional stiffness and bending stiffness of the nail-bone-construction. Expandable nails (interlocked nails) showed a lateral bending stiffness of 0.73 +/- 0.14 (0.63 +/- 0.1) KN/mm (P = 0.026) and a frontal bending stiffness of 0.67 +/- 0.18 (0.58 +/- 0.09) KN/mm (P = 0.084). Torsional stiffness values were 0.13 +/- 0.19 (0.43 +/- 0.09 Nm/degrees) (P = 0.012). Lower torsional stiffness in the expandable nail group was observed in humeri with a funnel shaped proximal intramedullary canal. The nail systems showed similar characteristics for frontal bending (P = 0.084), but not for lateral bending (P = 0.026). For lateral bending, the Fixion nail showed significantly more stiffness than the UHN nail (P = 0.026). There was significantly lower torsional stiffness with expandable nails compared with interlocked nails. Clinical correlation would suggest that in rotationally unstable fractures (A2 and A3 diaphyseal fractures), interlocked nails would provide increased stability over expandable nails.

  7. Triple Helix Model in Developing Technological Innovation: The Case of Computer Based Interlocking

    Directory of Open Access Journals (Sweden)

    Erry Ricardo Nurzal

    2013-01-01

    Full Text Available Computer Based Interlocking (CBI is the most important part of the electric railway signalingsystem which serves as the “brain” that controls the operation of electrical signaling system thatreplaces the role of the electromagnetic relay which has gradually been abandoned. Developmentof CBI is based on the fact that until recently the signaling system in Indonesia is still reliedheavily on the CBI products from foreign vendors. Therefore, the development of domestic CBIproducts is really necessary in order to decrease the dependence on technology from foreignvendors that at the same time is also be able to support the accelerated development of railwayinfrastructure in Indonesia.The CBI development is conducted in the form of a collaboration involving the government,universities, and industry. This paper explores and analyzes the roles and interactions betweendifferent actors in the triple helix perspective, and identifies how the innovation ecosystemfunctioning with support from the government.Based on the data collected through in-depth interview with the actors involved in the CBI casestudy, this paper gives some key findings. First, government role is very important in establishingan innovation ecosystem for CBI development. Second, the leader in the development of CBItechnological innovation should be the industry supported by governmental R & D institutionsand universities. Third, R & D consortium is an effective vehicle for creating an interactionamong industry, academia, and government.Such findings may provide conceptual direction which is important for the development oftechnological innovation in Indonesia. In addition, in providing support for R&D activities, thegovernment needs to direct its R & D incentives to the industry as a business practitioner with itsown technology roadmap. The possible further research may include some research issues. First,is the pattern occurred in the CBI case also applied in the other cases of

  8. Analytical and computational modeling of the mechanical interlocking between steel/FRP reinforcing bars and concrete

    Science.gov (United States)

    Yu, Hailing

    Mechanical interaction (commonly called bond) between concrete and reinforcing bars significantly affects the structural response of reinforced concrete. This study addresses modeling issues for the bond of steel and fiber-reinforced polymer---FRP bars. Two analysis scales are examined: the rib-scale (where the surface structure of the bar is often explicitly modeled) and the bar-scale (where the surface is idealized as smooth and an interface idealization is adopted). The study's main objective is to better understand how contact between concrete and a bar with a fabricated surface structure affects the radial elastic response and how these effects can be incorporated into bar-scale models. A limited modeling study on the local crushing near the ribs of a bar is also presented. Experimental or analytical justifications for the radial elastic modulus (D̂e) of a barscale model do not exist, yet D̂ e is important toward predicting bond behavior and splitting failures. A proposed analytical framework defines D̂e as characterizing the local elastic deformation resulting from mechanical interlocking. The approach enforces static and strain energy equivalencies of riband bar-scale idealizations. Assuming axisymmetric elastic behavior, homogeneous materials, and periodicity, closed-form analytical solutions are obtained for D̂ e. D̂e's dependence on interface traction distribution, material constants and bar geometry is studied for steel and FRP bars. D̂ e increases with the contact area but remains finite for full contact (assuming a nonuniform traction). For FRP bars, D̂e reproduces the radial snap-back behavior that occurs with longitudinal cracking, which helps explain the splitting behavior of some test specimens and the convergence problems in some numerical studies. For a steel bar D̂e is incorporated into a bar-scale bond model via a local contact model which leads to improved prediction of the radial response. Elastoplastic constitutive relations are

  9. Surface fractals in liposome aggregation.

    Science.gov (United States)

    Roldán-Vargas, Sándalo; Barnadas-Rodríguez, Ramon; Quesada-Pérez, Manuel; Estelrich, Joan; Callejas-Fernández, José

    2009-01-01

    In this work, the aggregation of charged liposomes induced by magnesium is investigated. Static and dynamic light scattering, Fourier-transform infrared spectroscopy, and cryotransmission electron microscopy are used as experimental techniques. In particular, multiple intracluster scattering is reduced to a negligible amount using a cross-correlation light scattering scheme. The analysis of the cluster structure, probed by means of static light scattering, reveals an evolution from surface fractals to mass fractals with increasing magnesium concentration. Cryotransmission electron microscopy micrographs of the aggregates are consistent with this interpretation. In addition, a comparative analysis of these results with those previously reported in the presence of calcium suggests that the different hydration energy between lipid vesicles when these divalent cations are present plays a fundamental role in the cluster morphology. This suggestion is also supported by infrared spectroscopy data. The kinetics of the aggregation processes is also analyzed through the time evolution of the mean diffusion coefficient of the aggregates.

  10. Laser characterization of fine aggregate.

    Science.gov (United States)

    2012-12-01

    This report describes the results of a research effort to establish the feasibility of using a laser monitoring system to provide real-time data to characterize aggregate properties in a laboratory or field environment. This was accomplished by using...

  11. "Fabrication of arbitrarily shaped carbonate apatite foam based on the interlocking process of dicalcium hydrogen phosphate dihydrate".

    Science.gov (United States)

    Sugiura, Yuki; Tsuru, Kanji; Ishikawa, Kunio

    2017-08-01

    Carbonate apatite (CO 3 Ap) foam with an interconnected porous structure is highly attractive as a scaffold for bone replacement. In this study, arbitrarily shaped CO 3 Ap foam was formed from α-tricalcium phosphate (α-TCP) foam granules via a two-step process involving treatment with acidic calcium phosphate solution followed by hydrothermal treatment with NaHCO 3 . The treatment with acidic calcium phosphate solution, which is key to fabricating arbitrarily shaped CO 3 Ap foam, enables dicalcium hydrogen phosphate dihydrate (DCPD) crystals to form on the α-TCP foam granules. The generated DCPD crystals cause the α-TCP granules to interlock with each other, inducing an α-TCP/DCPD foam. The interlocking structure containing DCPD crystals can survive hydrothermal treatment with NaHCO 3 . The arbitrarily shaped CO 3 Ap foam was fabricated from the α-TCP/DCPD foam via hydrothermal treatment at 200 °C for 24 h in the presence of a large amount of NaHCO 3 .

  12. Management of aseptic non-unions of the distal third of the tibial diaphysis using static interlocking intramedullary nailing.

    Science.gov (United States)

    Begkas, Dimitrios; Katsenis, Dimitrios; Pastroudis, Alexandros

    2014-02-01

    To evaluate the management of aseptic non-unions of the distal third of the tibial diaphysis, using static interlocking intramedullary nailing. Between January 2005 and November 2012, a total number of 42 patients who underwent surgery at our hospital for aseptic non-unions of the distal third of the tibial diaphysis, were included in our study. Preoperatively, all the patients were tested for the presence of infection of non-union. The post-operative follow up was based on clinical and radiological findings. Union was achieved in 41 (98%) patients, at a mean time of 5.8 months (four-eight months). One (2%) patient developed infection of the wound four weeks after the operation. A small decrease of the tibial length, of about one cm was seen in three (7%) patients. Pain of the patellar tendon, at the entry point of the nail, was observed in six (14%) patients, without impacting the range of motion of the knee. In two (5%) patients, a decrease in dorsiflexion of the ankle joint occurred, of about ten degrees angle. Static interlocking intramedullary nailing is the preferable technique in the management of aseptic non-unions of the distal third of the tibial diaphysis, because it provides high union rate and few postoperative complications. A good preoperative evaluation for infections, use of proper surgical technique with respect to soft tissues, use of autogenous bone grafts and early mobilization of patients, are the keys to success of this method.

  13. Three-dimensional iron sulfide-carbon interlocked graphene composites for high-performance sodium-ion storage

    DEFF Research Database (Denmark)

    Huang, Wei; Sun, Hongyu; Shangguan, Huihui

    2018-01-01

    Three-dimensional (3D) carbon-wrapped iron sulfide interlocked graphene (Fe7S8@C-G) composites for high-performance sodium-ion storage are designed and produced through electrostatic interactions and subsequent sulfurization. The iron-based metal–organic frameworks (MOFs, MIL-88-Fe) interact...... with graphene oxide sheets to form 3D networks, and carbon-wrapped iron sulfide (Fe7S8@C) nanoparticles with high individual-particle conductivity are prepared following a sulfurization process, surrounded by interlocked graphene sheets to enhance the interparticle conductivity. The prepared Fe7S8@C......, the Fe7S8@C-G composites exhibit a reversible capacity of 449 mA h g−1at 500 mA g−1 after 150 cycles and a retention capacity of 306 mA h g−1 under a current density of 2000 mA g−1. The crucial factors related to the structural changes and stability during cycles have been further investigated...

  14. Model for amorphous aggregation processes

    Science.gov (United States)

    Stranks, Samuel D.; Ecroyd, Heath; van Sluyter, Steven; Waters, Elizabeth J.; Carver, John A.; von Smekal, Lorenz

    2009-11-01

    The amorphous aggregation of proteins is associated with many phenomena, ranging from the formation of protein wine haze to the development of cataract in the eye lens and the precipitation of recombinant proteins during their expression and purification. While much literature exists describing models for linear protein aggregation, such as amyloid fibril formation, there are few reports of models which address amorphous aggregation. Here, we propose a model to describe the amorphous aggregation of proteins which is also more widely applicable to other situations where a similar process occurs, such as in the formation of colloids and nanoclusters. As first applications of the model, we have tested it against experimental turbidimetry data of three proteins relevant to the wine industry and biochemistry, namely, thaumatin, a thaumatinlike protein, and α -lactalbumin. The model is very robust and describes amorphous experimental data to a high degree of accuracy. Details about the aggregation process, such as shape parameters of the aggregates and rate constants, can also be extracted.

  15. Rolling Stones Down Potential Hills: Reshaping Gravitational Aggregates

    Science.gov (United States)

    Tanga, Paolo; Comito, C.; Hestroffer, D.; Paolicchi, P.; Walsh, K.; Richardson, D. C.

    2008-09-01

    Numerical N-body models adopting self-gravitating spherical particles have proven to have interesting properties and are very useful for describing some aspects of the expected behaviour of rubble-piles. In fact, particle interlocking can simulate a certain degree of shear strength (corresponding to a non-zero critical slope in the Mohr-Coulomb approach). At the same time, if the critical slope angle is exceeded for some reason (thus temporarily breaking the sphere packing) the shape of the body can readjust to a new equilibrium. Usually, this re-organisation produces a shape closer to the theoretical fluid equilibrium predicted by theory, at the corresponding angular momentum. We have recently compared this reshaping process of ellipsoidal gravitational aggregates to the field of potential energy associated with incompressible fluid shapes. The gradient of this field suggests the evolutionary track that a reshaping body undergoing a slow (quasi-stationary) modification should follow. The same applies to the gradient of the maximum slope present on the surface. The results show the overall tendency to readjust along the potential slope. However, other effects are at work, making the interpretation more complex - among them we can identify: the granularity of the shape model; the relative flatness of the potential field; and a certain anisotropy of the most compact spherical packings. The results offer an interesting insight into the detailed behaviour of this model, allowing us to characterize its applicability in more realistic situations, such as restructuring due to tidal forces, impact reshaping, or shape build-up during gravitational reaccumulation.

  16. Replacement of Fine Aggregate by using Recyclable Materials in Paving Blocks

    Science.gov (United States)

    Koganti, Shyam Prakash; Hemanthraja, Kommineni; Sajja, Satish

    2017-08-01

    Cement concrete paving blocks are precast hard products complete out of cement concrete. The product is made in various sizes and shapes like square, round and rectangular blocks of different dimensions with designs for interlocking of adjacent tiles blocks. Several Research Works have been carried out in the past to study the possibility of utilizing waste materials and industrial byproducts in the manufacturing of paver blocks. Various industrial waste materials like quarry dust, glass powder, ceramic dust and coal dust are used as partial replacement of fine aggregate and assessed the strength parameters and compared the profit percentages after replacement with waste materials. Quarry dust can be replaced by 20% and beyond that the difference in strength is not much higher but considering cost we can replace upto 40% so that we can get a profit of almost 10%. Similarly we can replace glass powder and ceramic dust by 20% only beyond that there is decrement in strength and even with 20% replacement we can get 1.34 % and 2.42% of profit. Coal dust is not suitable for alternative material as fine aggregate as it reduces the strength.

  17. Fractal Aggregates in Tennis Ball Systems

    Science.gov (United States)

    Sabin, J.; Bandin, M.; Prieto, G.; Sarmiento, F.

    2009-01-01

    We present a new practical exercise to explain the mechanisms of aggregation of some colloids which are otherwise not easy to understand. We have used tennis balls to simulate, in a visual way, the aggregation of colloids under reaction-limited colloid aggregation (RLCA) and diffusion-limited colloid aggregation (DLCA) regimes. We have used the…

  18. Aggregated recommendation through random forests.

    Science.gov (United States)

    Zhang, Heng-Ru; Min, Fan; He, Xu

    2014-01-01

    Aggregated recommendation refers to the process of suggesting one kind of items to a group of users. Compared to user-oriented or item-oriented approaches, it is more general and, therefore, more appropriate for cold-start recommendation. In this paper, we propose a random forest approach to create aggregated recommender systems. The approach is used to predict the rating of a group of users to a kind of items. In the preprocessing stage, we merge user, item, and rating information to construct an aggregated decision table, where rating information serves as the decision attribute. We also model the data conversion process corresponding to the new user, new item, and both new problems. In the training stage, a forest is built for the aggregated training set, where each leaf is assigned a distribution of discrete rating. In the testing stage, we present four predicting approaches to compute evaluation values based on the distribution of each tree. Experiments results on the well-known MovieLens dataset show that the aggregated approach maintains an acceptable level of accuracy.

  19. Close Intramedullary Interlocking Nailing Versus Locking Compression Plating In the Treatment of Closed Fracture Shaft of the Tibia.

    Science.gov (United States)

    Kundu, I K; Datta, N K; Chowdhury, A Z; Das, K P; Tarik, M M; Faisal, M A

    2016-07-01

    Fracture of tibial shaft is the commonest site of long bone fractures due to its superficial location involving young or middle-age people. Proper management is an important issue regarding the future effective movements. In this study patients were grouped in closed Intra medullary interlocking nailing and locking compression plating. Post-operative follow up at 2 weeks, 6 weeks, 12 weeks and 3 months thereafter up to 6 months were done. Each of the patients was evaluated clinically and radiologically by tucker criteria of Tuker et al. Patients were assessed for pain on full weight bearing and kneeling, shortening and range of motion of knee and ankle joints. Radiological assessment for union of fracture, alignment of fracture and angulations and position of nail and screws and infection were observed during follow up. A total number of 32 patients were selected but only 27 patients were available for follow up for a period of 6 months. They were grouped into Group A, consisting of 15 patients who took the treatment in the form of closed intramedullary interlocking nailing and Group B, consisting of 12 patients those underwent ORIF with locking compression plating. In both of the groups Motor Vehicle Accident was the main mechanism of trauma. Fracture involving the middle 3rd of the tibia is common in both the groups. During post-operative follow up, four patients in Group A complained anterior knee pain, one patient in Group B had superficial infection, most of the patients had no restriction of movement in the ankle and knee joints and a single patient in Group B showed 1.5cm shortening of the lower limb. Period of hospital stay and fracture union time were less in Group A, which was statistically significant. Both groups showed excellent result with minimum complications. So this study permits to conclude that close IM interlocking nailing and open reduction and internal fixation by locking compression plating is equally effective for the management of close

  20. Customer Aggregation: An Opportunity for Green Power?

    Energy Technology Data Exchange (ETDEWEB)

    Holt, E.; Bird, L.

    2001-02-26

    We undertook research into the experience of aggregation groups to determine whether customer aggregation offers an opportunity to bring green power choices to more customers. The objectives of this report, therefore, are to (1) identify the different types of aggregation that are occurring today, (2) learn whether aggregation offers an opportunity to advance sales of green power, and (3) share these concepts and approaches with potential aggregators and green power advocates.

  1. SHAPE CHARACTERIZATION OF CONCRETE AGGREGATE

    Directory of Open Access Journals (Sweden)

    Jing Hu

    2011-05-01

    Full Text Available As a composite material, the performance of concrete materials can be expected to depend on the properties of the interfaces between its two major components, aggregate and cement paste. The microstructure at the interfacial transition zone (ITZ is assumed to be different from the bulk material. In general, properties of conventional concrete have been found favoured by optimum packing density of the aggregate. Particle size is a common denominator in such studies. Size segregation in the ITZ among the binder particles in the fresh state, observed in simulation studies by concurrent algorithm-based SPACE system, additionally governs density as well as physical bonding capacity inside these shell-like zones around aggregate particles. These characteristics have been demonstrated qualitatively pertaining also after maturation of the concrete. Such properties of the ITZs have direct impact on composite properties. Despite experimental approaches revealed effects of aggregate grain shape on different features of material structure (among which density, and as a consequence on mechanical properties, it is still an underrated factor in laboratory studies, probably due to the general feeling that a suitable methodology for shape characterization is not available. A scientific argument hindering progress is the interconnected nature of size and shape. Presently, a practical problem preventing shape effects to be emphasized is the limitation of most computer simulation systems in concrete technology to spherical particles. New developments at Delft University of Technology will make it possible in the near future to generate jammed states, or other high-density fresh particle mixtures of non-spherical particles, which thereupon can be subjected to hydration algorithms. This paper will sketch the outlines of a methodological approach for shape assessment of loose (non-embedded aggregate grains, and demonstrate its use for two types of aggregate, allowing

  2. Platelet aggregates and ADP-induced platelet aggregation in ...

    African Journals Online (AJOL)

    Hypertension is a condition characterized by haemodynamic vascular stress and abnormal blood flow under high pressure and it is associated with complications that are, paradoxically, thrombotic rather than haemorrhagic. Spontaneous platelet aggregation has been known to be present in hypertension which predicts ...

  3. Environmentalism and natural aggregate mining

    Science.gov (United States)

    Drew, L.J.; Langer, W.H.; Sachs, J.S.

    2002-01-01

    Sustaining a developed economy and expanding a developing one require the use of large volumes of natural aggregate. Almost all human activity (commercial, recreational, or leisure) is transacted in or on facilities constructed from natural aggregate. In our urban and suburban worlds, we are almost totally dependent on supplies of water collected behind dams and transported through aqueducts made from concrete. Natural aggregate is essential to the facilities that produce energy-hydroelectric dams and coal-fired powerplants. Ironically, the utility created for mankind by the use of natural aggregate is rarely compared favorably with the environmental impacts of mining it. Instead, the empty quarries and pits are seen as large negative environmental consequences. At the root of this disassociation is the philosophy of environmentalism, which flavors our perceptions of the excavation, processing, and distribution of natural aggregate. The two end-member ideas in this philosophy are ecocentrism and anthropocentrism. Ecocentrism takes the position that the natural world is a organism whose arteries are the rivers-their flow must not be altered. The soil is another vital organ and must not be covered with concrete and asphalt. The motto of the ecocentrist is "man must live more lightly on the land." The anthropocentrist wants clean water and air and an uncluttered landscape for human use. Mining is allowed and even encouraged, but dust and noise from quarry and pit operations must be minimized. The large volume of truck traffic is viewed as a real menace to human life and should be regulated and isolated. The environmental problems that the producers of natural aggregate (crushed stone and sand and gravel) face today are mostly difficult social and political concerns associated with the large holes dug in the ground and the large volume of heavy truck traffic associated with quarry and pit operations. These concerns have increased in recent years as society's demand for

  4. Interlocked chiral/polar domain walls and large optical rotation in Ni3TeO6

    Directory of Open Access Journals (Sweden)

    Xueyun Wang

    2015-07-01

    Full Text Available Chirality, i.e., handedness, pervades much of modern science from elementary particles, DNA-based biology to molecular chemistry; however, most of the chirality-relevant materials have been based on complex molecules. Here, we report inorganic single-crystalline Ni3TeO6, forming in a corundum-related R3 structure with both chirality and polarity. These chiral Ni3TeO6 single crystals exhibit a large optical specific rotation (α—1355° dm−1 cm3 g−1. We demonstrate, for the first time, that in Ni3TeO6, chiral and polar domains form an intriguing domain pattern, resembling a radiation warning sign, which stems from interlocked chiral and polar domain walls through lowering of the wall energy.

  5. Fibre Monitoring System for the Beam Permit Loops at the LHC and Future Evolution of the Beam Interlock System

    CERN Document Server

    García-Argos, Carlos; Gabourin, Stéphane; Martin, Christophe; Puccio, Bruno; Siemko, Andrzej P.

    The optical fibres that transmit the beam permit loop signals at the CERN accelerator complex are deployed along radiation areas. This may result in increased attenuation of the fibres, which reduces the power margin of the links. In addition, other events may cause the links to not function properly and result in false dumps, reducing the availability of the accelerator chain and affecting physics data taking. In order to evaluate the state of the fibres, an out-of-band fibre monitoring system is proposed, working in parallel to the actual beam permit loops. The future beam interlock system to be deployed during LHC long shutdown 2 will implement online, real-time monitoring of the fibres, a feature the current system lacks. Commercial off-the-shelf components to implement the optical transceivers are proposed whenever possible instead of ad-hoc designs.

  6. Outsourcing the development of specific application software using the ESA software engineering standards the SPS software Interlock System

    CERN Document Server

    Denis, B

    1995-01-01

    CERN is considering outsourcing as a solution to the reduction of staff. To need to re-engineer the SPS Software Interlock System provided an opportunity to explore the applicability of outsourcing to our specific controls environment and the ESA PSS-05 standards were selected for the requirements specification, the development, the control and monitoring and the project management. The software produced by the contractor is now fully operational. After outlining the scope and the complexity of the project, a discussion on the ESA PSS-05 will be presented: the choice, the way these standards improve the outsourcing process, the quality induced but also the need to adapt them and their limitation in the definition of the customer-supplier relationship. The success factors and the difficulties of development under contract will also be discussed. The maintenance aspect and the impact on in-house developments will finally be addressed.

  7. Measurement of the ground-state distributions in bistable mechanically interlocked molecules using slow scan rate cyclic voltammetry.

    Science.gov (United States)

    Fahrenbach, Albert C; Barnes, Jonathan C; Li, Hao; Benítez, Diego; Basuray, Ashish N; Fang, Lei; Sue, Chi-Hau; Barin, Gokhan; Dey, Sanjeev K; Goddard, William A; Stoddart, J Fraser

    2011-12-20

    In donor-acceptor mechanically interlocked molecules that exhibit bistability, the relative populations of the translational isomers--present, for example, in a bistable [2]rotaxane, as well as in a couple of bistable [2]catenanes of the donor-acceptor vintage--can be elucidated by slow scan rate cyclic voltammetry. The practice of transitioning from a fast scan rate regime to a slow one permits the measurement of an intermediate redox couple that is a function of the equilibrium that exists between the two translational isomers in the case of all three mechanically interlocked molecules investigated. These intermediate redox potentials can be used to calculate the ground-state distribution constants, K. Whereas, (i) in the case of the bistable [2]rotaxane, composed of a dumbbell component containing π-electron-rich tetrathiafulvalene and dioxynaphthalene recognition sites for the ring component (namely, a tetracationic cyclophane, containing two π-electron-deficient bipyridinium units), a value for K of 10 ± 2 is calculated, (ii) in the case of the two bistable [2]catenanes--one containing a crown ether with tetrathiafulvalene and dioxynaphthalene recognition sites for the tetracationic cyclophane, and the other, tetrathiafulvalene and butadiyne recognition sites--the values for K are orders (one and three, respectively) of magnitude greater. This observation, which has also been probed by theoretical calculations, supports the hypothesis that the extra stability of one translational isomer over the other is because of the influence of the enforced side-on donor-acceptor interactions brought about by both π-electron-rich recognition sites being part of a macrocyclic polyether.

  8. Interlocking multi-material components made of structured steel sheets and high-pressure die cast aluminium

    Science.gov (United States)

    Senge, S.; Brachmann, J.; Hirt, G.; Bührig-Polaczek, A.

    2017-10-01

    Lightweight design is a major driving force of innovation, especially in the automotive industry. Using hybrid components made of two or more different materials is one approach to reduce the vehicles weight and decrease fuel consumption. As a possible way to increase the stiffness of multi-material components, this paper presents a process chain to produce such components made of steel sheets and high-pressure die cast aluminium. Prior to the casting sequence the steel sheets are structured in a modified rolling process which enables continuous interlocking with the aluminium. Two structures manufactured by this rolling process are tested. The first one is a channel like structure and the second one is a channel like structure with undercuts. These undercuts enable the formation of small anchors when the molten aluminium fills them. The correlation between thickness reduction during rolling and the shape of the resulting structure was evaluated for both structures. It can be stated that channels with a depth of up to 0.5 mm and a width of 1 mm could be created. Undercuts with different size depending on the thickness reduction could be realised. Subsequent aluminium high-pressure die casting experiments were performed to determine if the surface structure can be filled gap-free with molten aluminium during the casting sequence and if a gap-free connection can be achieved after contraction of the aluminium. The casting experiments showed that both structures could be filled during the high-pressure die casting. The channel like structure results in a gap between steel and aluminium after contraction of the cast metal whereas the structure with undercuts leads to a good interlocking resulting in a gap-free connection.

  9. Diversity, intent, and aggregated search

    NARCIS (Netherlands)

    de Rijke, M.

    2014-01-01

    Diversity, intent and aggregated search are three core retrieval concepts that receive significant attention. In search result diversification one typically considers the relevance of a document in light of other retrieved documents. The goal is to identify the probable "aspects" of an ambiguous

  10. Shape characterization of concrete aggregate

    NARCIS (Netherlands)

    Stroeven, P.; Hu, J.

    2006-01-01

    As a composite material, the performance of concrete materials can be expected to depend on the properties of the interfaces between its two major components, aggregate and cement paste. The microstructure at the interfacial transition zone (ITZ) is assumed to be different from the bulk material. In

  11. Studies on recycled aggregates-based concrete.

    Science.gov (United States)

    Rakshvir, Major; Barai, Sudhirkumar V

    2006-06-01

    Reduced extraction of raw materials, reduced transportation cost, improved profits, reduced environmental impact and fast-depleting reserves of conventional natural aggregates has necessitated the use of recycling, in order to be able to conserve conventional natural aggregate. In this study various physical and mechanical properties of recycled concrete aggregates were examined. Recycled concrete aggregates are different from natural aggregates and concrete made from them has specific properties. The percentages of recycled concrete aggregates were varied and it was observed that properties such as compressive strength showed a decrease of up to 10% as the percentage of recycled concrete aggregates increased. Water absorption of recycled aggregates was found to be greater than natural aggregates, and this needs to be compensated during mix design.

  12. Análise experimental de blocos intertravados de concreto com adição de resíduos do processo de recauchutagem de pneus = Analysis of experimental interlocking blocks of concrete with addition of residues of process the tires retreading production

    Directory of Open Access Journals (Sweden)

    Cesar Fabiano Fioriti

    2010-07-01

    of concrete with residues tires. We accomplished tests of compression strength, water absorption and resistance to impact. Through the preliminary results, we verified that are satisfactory, confirming the possibility of applying this type of interlocking block in environments with low demand, which would bring the economy of natural sources of aggregates, beyond ecological benefits through the reuse of residues from retreading of tires.

  13. Early Conversion of External Fixation to Interlocked Nailing in Open Fractures of Both Bone Leg Assisted with Vacuum Closure (VAC) - Final Outcome.

    Science.gov (United States)

    Gill, Simrat Pal Singh; Raj, Manish; Kumar, Sunil; Singh, Pulkesh; Kumar, Dinesh; Singh, Jasveer; Deep, Akash

    2016-02-01

    Management of compound grade III fractures of both bone leg includes external stabilization for long period, followed by various soft tissue coverage procedures. Primary interlocking of tibia had been also done with variable results. External fixation for long time without any bone loss often leads to infected nonunion, loss of reduction, pin tract infection and failure of fixation, primary interlocking in compound grade III fractures had shown high medullary infection rate. We managed all cases of compound grade III A/B fractures with primary external fixation, simultaneous wound management using vacuum assisted closure (VAC) followed by early conversion to interlocking within 2 weeks of fixator application. To determine the effectiveness of vacuum assisted closure (VAC) for the early conversion of external fixator to definitive interlocking in open fractures of the both bone leg. In current study we selected 84 cases of compound grade IIIA/B diaphyseal fractures of both bone leg during period of May 2010 to September 2013. We managed these cases by immediate debridement and application of external fixation followed by repeated debridement, application of vacuum assisted closure (VAC) and conversion to interlocking within two weeks. Out of 84 cases union was achieved in 80(95%) of cases with definitive tibial interlocking. Excellent to good result were obtained in 77(91.8%) of cases and fair to poor result seen in rest of 7(8.2%) of cases according to modified Ketenjian's criteria. 5 out of these 7 poor result group cases were from Compound Grade III B group to start with. Deep infection rate in our series were 7% i.e. total 6 cases and 4 out of these were from compound Grade III B group to start with. Vacuum assisted closure (VAC) give a good help for rapid closure of the wound and help in early conversion to definitive intramedullary nailing. Reamed nail could well be used in compound grade IIIA/B fractures without increasing the risk of infection. It gives

  14. Role of multicellular aggregates in biofilm formation

    DEFF Research Database (Denmark)

    Kragh, Kasper N.; Hutchison, Jaime B.; Melaugh, Gavin

    2016-01-01

    initiation and development is not known. Here we use a combination of experimental and computational approaches to determine the relative fitness of single cells and preformed aggregates during early development of Pseudomonas aeruginosa biofilms. We find that the relative fitness of aggregates depends...... markedly on the density of surrounding single cells, i.e., the level of competition for growth resources. When competition between aggregates and single cells is low, an aggregate has a growth disadvantage because the aggregate interior has poor access to growth resources. However, if competition is high......, aggregates exhibit higher fitness, because extending vertically above the surface gives cells at the top of aggregates better access to growth resources. Other advantages of seeding by aggregates, such as earlier switching to a biofilm-like phenotype and enhanced resilience toward antibiotics and immune...

  15. Recycled concrete aggregate in portland cement concrete.

    Science.gov (United States)

    2013-01-01

    Aggregates can be produced by crushing hydraulic cement concrete and are known as recycled concrete : aggregates (RCA). This report provides results from a New Jersey Department of Transportation study to identify : barriers to the use of RCA in new ...

  16. Estimation of Line Efficiency by Aggregation

    NARCIS (Netherlands)

    M.B.M. de Koster (René)

    1987-01-01

    textabstractPresents a multi-stage flow lines with intermediate buffers approximated by two-stage lines using repeated aggregation. Characteristics of the aggregation method; Problems associated with the analysis and design of production lines.

  17. Catanionic aggregates stability and structure

    International Nuclear Information System (INIS)

    Vautrin, Claire

    2004-01-01

    The catanionic system cetyl-trimethyl-ammonium hydroxide - myristic acid - water studied here has the advantage to produce aggregates with controlled charge. So, the ternary phase diagram presents some interesting aggregates (micelle, vesicle, disc, lamellar phase). The study of the CMC put in evidence some strong interactions between monomers: the interaction parameter is equal to -10 kT. On a microscopic point of view, the alkyl chains packing is hexagonal and we proved by WAXS and WANS that the head groups are liquid ordered. Moreover, the hydrogen bonds participate to the bilayer cohesion. The mechanical properties of the catanionic membrane are similar to the properties of phospholipids. We estimated the Young modulus to 100 MPa by compressibility measurements (acoustic propagation and Langmuir trough). The thermodynamic properties studied by DSC showed that the chain melting transition depends on the sample composition. (author) [fr

  18. Parametric characterization of aggregation functions

    Czech Academy of Sciences Publication Activity Database

    Mesiar, Radko; Kolesárová, A.

    2009-01-01

    Roč. 160, č. 6 (2009), s. 816-831 ISSN 0165-0114 R&D Projects: GA ČR GA402/08/0618 Institutional research plan: CEZ:AV0Z10750506 Keywords : Aggregation function * Conjunction measure * Disjunction measure * Global/local parametric characterization * Idempotency measure Subject RIV: BA - General Mathematics Impact factor: 2.138, year: 2009 http://library.utia.cas.cz/separaty/2009/E/mesiar-parametriccharacterizationofaggregationfunctions.pdf

  19. Intuitionistic fuzzy aggregation and clustering

    CERN Document Server

    Xu, Zeshui

    2012-01-01

    This book offers a systematic introduction to the clustering algorithms for intuitionistic fuzzy values, the latest research results in intuitionistic fuzzy aggregation techniques, the extended results in interval-valued intuitionistic fuzzy environments, and their applications in multi-attribute decision making, such as supply chain management, military system performance evaluation, project management, venture capital, information system selection, building materials classification, and operational plan assessment, etc.

  20. Familial aggregation of cluster headache

    Directory of Open Access Journals (Sweden)

    Simao Cruz

    2013-11-01

    Full Text Available Several studies suggest a strong familial aggregation for cluster headache (CH, but so far none of them have included subjects with probable cluster headache (PCH in accordance with the International Classification of Headache Disorders. Objective To identify cases of probable cluster headache and to assess the familial aggregation of cluster headache by including these subjects. Method Thirty-six patients attending a headache consultation and diagnosed with trigeminal autonomic headaches were subjected to a questionnaire-based interview. A telephone interview was also applied to all the relatives who were pointed out as possibly affected as well as to some of the remaining relatives. Results Twenty-four probands fulfilled the criteria for CH or PCH; they had 142 first-degree relatives, of whom five were found to have CH or PCH, including one case of CH sine headache. The risk for first-degree relatives was observed to be increased by 35- to 46-fold. Conclusion Our results suggest a familial aggregation of cluster headache in the Portuguese population.

  1. Correspondences in the theory of aggregation

    NARCIS (Netherlands)

    Grossi, D.; Bonanno, G.; Löwe, B.; van der Hoek, W.

    2010-01-01

    The paper studies the interrelationships between the social-theoretic problems of preference and judgment aggregation from the perspective of formal logic. The result of the paper is twofold. On the one hand, preference aggregation on total preorders is proven equivalent to the aggregation of

  2. Studies of the aggregation of RNase Sa

    DEFF Research Database (Denmark)

    Khasa, Harshit; Kramer, Ryan; Maddux, Nathan

    2014-01-01

    of the mutants, little correlation was seen between the time at which aggregation is initiated or the rate of aggregation and the thermal sensitivity of the mutants. It is hypothesized that the nature of contacts between protein molecules in the associated (aggregated) phase rather than structural changes...

  3. Multi-Dimensional Aggregation for Temporal Data

    DEFF Research Database (Denmark)

    Böhlen, M. H.; Gamper, J.; Jensen, Christian Søndergaard

    2006-01-01

    Business Intelligence solutions, encompassing technologies such as multi-dimensional data modeling and aggregate query processing, are being applied increasingly to non-traditional data. This paper extends multi-dimensional aggregation to apply to data with associated interval values that capture...... sets and is competitive with respect to other temporal aggregation algorithms....

  4. Aggregation and Control of Flexible Consumers

    DEFF Research Database (Denmark)

    Biegel, Benjamin; Andersen, Palle; Stoustrup, Jakob

    2014-01-01

    In this paper, we present an architecture for aggregation and co ntrol of a portfolio of flexible consumers. The architecture makes it possible to control the aggregated consumption of the portfolio to follow a power reference while honoring local consumer constraints. Hereby, an aggregator is ab...

  5. Reliability Analysis of the new Link between the Beam Interlock System and the LHC Beam Dumping System Zuverlässigkeitsanalyse der neuen Verbindung zwischen dem Beam Interlock System und dem LHC Beam Dumping System

    CERN Document Server

    Vatansever, Volkan

    The nominal stored energy in each LHC beam is 360 MJ, surpassing the beam energy of other accelerators by orders of magnitude. This energy threatens to damage accelerator components in case of uncontrolled beam losses To avoid damage of accelerator equipment due to impacting beam, the controlled removal of the LHC beams from the collider rings towards the dump block must be guaranteed at all times. Therefore, the LHC Beam Dumping System was built according to high reliability standards. To further reduce the risk of incapability to dump the beams in case of correlated failures in the redundant system, a new direct link from the LHC Beam Interlock System to the Re-triggering Lines of the LHC Beam Dumping System will be implemented for the startup with beam in 2015. This link represents a diverse redundancy to the current implementation, which should neither significantly increase the risk for so-called Asynchronous Beam Dumps nor compromise machine availability. Therefore, a reliability analysis down to the co...

  6. Operability of the Ventilation Continuous Air Monitor (CAM) Interlock Analysis of Proposed Upgrade to the 241AW Farm Primary Exhauster CAM System

    International Nuclear Information System (INIS)

    GUSTAVSON, R.D.

    2002-01-01

    The Tank Farms Final Safety Analysis (FSAR) assumes that a ventilation stack Continuous Air Monitor (CAM) interlock system detects high radiation in the exhaust stream and shuts off the associated ventilation system within 10 minutes of a High-Efficiency Particulate Air (HEPA) filter system failure (CHG, 2002). Previous analysis of the as-built CAM system on the AW Farm Primary Exhauster (stack 296-A-27) showed that this system potentially required significantly longer than 10 minutes to detect a HEPA filter failure and initiate shutdown of the ventilation system (Short, 2002). The purpose of this report is to determine the CAM interlock system response time for a proposed upgrade of the 296-A-27 CAM system. The approach to be used in this analysis is essentially the same as used in RPP-10799, Rev. 0 (Short, 2002), which is to conservatively estimate the time required by the proposed upgraded CAM sampling/monitoring system to detect a FSAR-defined HEPA filter failure and automatically shutdown the exhaust fan. For the HEPA filter failure over-temperature accident scenario in the FSAR, the upgraded CAM system on the AW Farm Primary Exhauster will require significantly less than 10 minutes to detect a HEPA filter failure, actuate the CAM Interlock, and shutdown the exhauster fan. Therefore, the analyzed system is adequate to meet the operability requirements specified in the FSAR and the Tank Farms Technical Safety Requirements (CHG, 2001; CHG, 2002)

  7. Two-species aggregation processes with migration

    International Nuclear Information System (INIS)

    Ke Jianhong; Zhuang Youyi; Lin Zhenquan

    2004-01-01

    We study the kinetic behaviour of an aggregation-migration model, in which irreversible aggregations occur between any two aggregates of the same species and reversible migrations occur simultaneously between two different species. For a simple model with constant aggregation rate kernels as well as size-dependent migration rate kernels, we find that the evolution behaviour of the system depends crucially on the ratios of the aggregation rate coefficients to the migration rate coefficient. In general, the aggregate size distributions of the aggregation-migration processes always obey a conventional or generalized scaling law. Moreover, both species survive together for some cases, while only one species can be conserved finally for other cases

  8. Heating of Porous Icy Dust Aggregates

    Energy Technology Data Exchange (ETDEWEB)

    Sirono, Sin-iti [Earth and Environmental Sciences, Nagoya University, Tikusa-ku, Furo-cho, Nagoya 464-8601 (Japan)

    2017-06-10

    At the beginning of planetary formation, highly porous dust aggregates are formed through coagulation of dust grains. Outside the snowline, the main component of an aggregate is H{sub 2}O ice. Because H{sub 2}O ice is formed in amorphous form, its thermal conductivity is extremely small. Therefore, the thermal conductivity of an icy dust aggregate is low. There is a possibility of heating inside an aggregate owing to the decay of radionuclides. It is shown that the temperature increases substantially inside an aggregate, leading to crystallization of amorphous ice. During the crystallization, the temperature further increases sufficiently to continue sintering. The mechanical properties of icy dust aggregates change, and the collisional evolution of dust aggregates is affected by the sintering.

  9. Sequence-dependent internalization of aggregating peptides.

    Science.gov (United States)

    Couceiro, José R; Gallardo, Rodrigo; De Smet, Frederik; De Baets, Greet; Baatsen, Pieter; Annaert, Wim; Roose, Kenny; Saelens, Xavier; Schymkowitz, Joost; Rousseau, Frederic

    2015-01-02

    Recently, a number of aggregation disease polypeptides have been shown to spread from cell to cell, thereby displaying prionoid behavior. Studying aggregate internalization, however, is often hampered by the complex kinetics of the aggregation process, resulting in the concomitant uptake of aggregates of different sizes by competing mechanisms, which makes it difficult to isolate pathway-specific responses to aggregates. We designed synthetic aggregating peptides bearing different aggregation propensities with the aim of producing modes of uptake that are sufficiently distinct to differentially analyze the cellular response to internalization. We found that small acidic aggregates (≤500 nm in diameter) were taken up by nonspecific endocytosis as part of the fluid phase and traveled through the endosomal compartment to lysosomes. By contrast, bigger basic aggregates (>1 μm) were taken up through a mechanism dependent on cytoskeletal reorganization and membrane remodeling with the morphological hallmarks of phagocytosis. Importantly, the properties of these aggregates determined not only the mechanism of internalization but also the involvement of the proteostatic machinery (the assembly of interconnected networks that control the biogenesis, folding, trafficking, and degradation of proteins) in the process; whereas the internalization of small acidic aggregates is HSF1-independent, the uptake of larger basic aggregates was HSF1-dependent, requiring Hsp70. Our results show that the biophysical properties of aggregates determine both their mechanism of internalization and proteostatic response. It remains to be seen whether these differences in cellular response contribute to the particular role of specific aggregated proteins in disease. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  10. Credit, Money, and Aggregate Demand.

    OpenAIRE

    Bernanke, Ben S; Blinder, Alan S

    1988-01-01

    Standard models of aggregate demand treat money and credit asymmetrically; money is given a special status, while loans, bonds, and other debt instruments are lumped together in a "bond market" and suppressed by Walras' Law. This makes bank liabilities central to the monetary transmission mechanism, while giving no role to bank assets. We show how to modify a textbook IS-UI model so as to permit a more balanced treatment. As in Tobin (1969) and Brunner-Meltzer (1972), the key assumption is th...

  11. Shutdown channels and fitted interlocks in atomic reactors; Chaines de securite et verrouillages installes sur les piles atomiques

    Energy Technology Data Exchange (ETDEWEB)

    Furet, J.; Landauer, C. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1968-07-01

    This catalogue consists of tables (one per reactor) giving the following information: number and type of detectors, range of the shutdown channels, nature of the associated electronics, thresholds setting off the alarms, fitted interlocks. These cards have been drawn up with a view to an examination of the reactors safety by the 'Reactor Safety Sub-Commission', they take into account the latest decisions. The reactors involved in this review are: Azur, Cabri, Castor-Pollux, Cesar-Marius-2, Edf-2, EL3, EL4, Eole, G1, G2-G3, Harmonie, Isis, Masurca, Melusine, Minerve, Osiris, Pegase, Peggy, PAT, Rapsodie, SENA, Siloe, Siloette, Triton-Nereide, and Ulysse. (authors) [French] Ce catalogue est compose d'un ensemble de tableaux (a raison de un tableau par pile) donnant les renseignements suivants: nombre et nature des detecteurs, dynamique des chaines, nature de l'electronique associee, seuils provoquant des actions de securite, verrouillages installes. Ces fiches ont ete etablies en vue de l'examen de la securite des piles par la 'Sous-Commission de Surete des Piles', et tiennent compte des decisions de celle-ci. Les reacteurs concernes sont: Azur, Cabri, Cator-Pollux, Cesar-Marius-2, Edf-2, EL3, EL4, Eole, G1, G2-G3, Harmonie, Isis, Masurca, Melusine, Minerve, Osiris, Pegase, Peggy, PAT, Rapsodie, SENA, Siloe, Siloette, Triton-Nereide, et Ulysse. (auteurs)

  12. Reamed interlocking intramedullary nailing for the treatment of tibial diaphyseal fractures and aseptic nonunions. Can we expect an optimum result?

    Science.gov (United States)

    Chalidis, Byron E; Petsatodis, George E; Sachinis, Nick C; Dimitriou, Christos G; Christodoulou, Anastasios G

    2009-10-01

    The need for reaming and the number of locking screws to be used in intramedullary (IM) tibial nailing of acute fractures as well as routine bone grafting of tibial aseptic nonunions have not been clearly defined. We describe the results of reamed interlocked IM nails in 233 patients with 247 tibial fractures (190 closed, 27 open and 30 nonunions). Ninety-six percent of the fractures were united at review after an average of 4.9 years. No correlation was found between union and nail diameter (P = 0.501) or the number of locking screws used (P = 0.287). Nail dynamization was effective in 82% of fractures. Locking screw(s) breakage was associated with nonunion in 25% of cases. Bone grafting during IM nailing was found not to increase the healing rate in tibial nonunions (P = 0.623). None of the IM nails were removed or revised due to infection. A dropped hallux and postoperative compartment syndrome were found in 0.8 and 1.6% of cases, respectively. Anterior knee pain was reported in 42% of patients but nail removal did not alleviate the symptoms in almost half. This series confirms the place of reamed intramedullary nailing for the vast majority of tibial diaphyseal fractures. It provides an optimum outcome and minimizes the need for supplementary bone grafting in aseptic nonunions.

  13. Our Electron, Proton and Neutron Models Predict Atom Building from Three-ring Orthogonal Interlocks of Properly Quarked Nucleons.

    Science.gov (United States)

    McLeod, Roger; McLeod, David

    2008-04-01

    We posited flatland electron loop strings from transversely vibrating neutrino strings. Loop traveling waves TWs alternately become upwardly deflecting standing waves SWs along each half-wave segment between non-vibrating node pairs. Descending SWs again revert to TWs at flatland, as far as the next two adjacent nodal pairs, where folding continues and new SWs descend, then ascend, and repetition follows. Three dimensional objects, not points, result. A broken ``linear'' electron string and its electron spring constant are compressed within stars until linear mass density is compatible with incorporation into a stable three-ring proton string. The created neutron has two down quarks and one up, but must be unstable because it lacks overpass-underpass interlocks of our proton that shared its linear charge density of two up quarks and one down quark with the electron, becoming neutral. Anu transversely aligned neutron can have one of its ``notches'' pushed into the acceptor notch of a proton, and deuterium results. Tritium may be a compatible ``catch'' of another neutron. An alpha particle follows when a second proton is forced in, creating a stable ``tic-tac-toe'' grid. Atom building proceeds routinely.

  14. Molecular annotation of ketol-acid reductoisomerases from Streptomyces reveals a novel amino acid biosynthesis interlock mediated by enzyme promiscuity

    Science.gov (United States)

    Verdel-Aranda, Karina; López-Cortina, Susana T; Hodgson, David A; Barona-Gómez, Francisco

    2015-01-01

    The 6-phosphogluconate dehydrogenase superfamily oxidize and reduce a wide range of substrates, making their functional annotation challenging. Ketol-acid reductoisomerase (KARI), encoded by the ilvC gene in branched-chain amino acids biosynthesis, is a promiscuous reductase enzyme within this superfamily. Here, we obtain steady-state enzyme kinetic parameters for 10 IlvC homologues from the genera Streptomyces and Corynebacterium, upon eight selected chemically diverse substrates, including some not normally recognized by enzymes of this superfamily. This biochemical data suggested a Streptomyces biosynthetic interlock between proline and the branched-chain amino acids, mediated by enzyme substrate promiscuity, which was confirmed via mutagenesis and complementation analyses of the proC, ilvC1 and ilvC2 genes in Streptomyces coelicolor. Moreover, both ilvC orthologues and paralogues were analysed, such that the relationship between gene duplication and functional diversification could be explored. The KARI paralogues present in S. coelicolor and Streptomyces lividans, despite their conserved high sequence identity (97%), were shown to be more promiscuous, suggesting a recent functional diversification. In contrast, the KARI paralogue from Streptomyces viridifaciens showed selectivity towards the synthesis of valine precursors, explaining its recruitment within the biosynthetic gene cluster of valanimycin. These results allowed us to assess substrate promiscuity indices as a tool to annotate new molecular functions with metabolic implications. PMID:25296650

  15. Rat platelet aggregation by ATP. Aggregometrical and ultrastructural comparison with aggregations induced by ADP and collagen.

    Science.gov (United States)

    Ts'ao, C.

    1976-01-01

    This paper describes the aggregation of rat platelets by adenosine triphosphate (ATP). The aggregometry of ATP-induced aggregation and the ultrastructure of ATP-aggregated platelets were compared and contrasted with those of adenosine diphosphate (ADP)-treated and collagen-treated samples. Human platelets were also studied alongside with rat specimens. Several lines of evidence indicate that the ATP-induced aggregation of rat platelet-rich plasma (PRP) is not a result of contaminating ADP in the ATP preparation. ATP did not cause aggregation of human platelets; it inhibited ADP- and collagen-induced human platelet aggregation. ATP pretreated with a creatine phosphate/creatine phosphokinase system caused similar rat platelet aggregation as did ATP not treated with this system. The aggregometry of ATP-induced aggregation of rat PRP was similar to that of collagen-induced aggregation but markedly different from that of ADP-induced aggregation. However, the nature of ATP-induced aggregation was similar to that induced by ADP. Both ATP- and ADP-induced rat platelet aggregations were not affected by adenosine, adenosine monophosphate, or acetylsalicylic acid. The ultrastructure of ATP-aggregated platelets was similar to that of ADP-aggregated ones. It appears that either platelets of rats possess specific ATP receptors or the rat plasma contains a material, lacking or insufficiently present in human plasma, that converts ATP to ADP in a fashion similar to the release of ADP from platelet storage granules. Images Figure 1 PMID:998732

  16. Natural aggregates of the conterminous United States

    Science.gov (United States)

    Langer, William H.

    1988-01-01

    Crushed stone and sand and gravel are the two main sources of natural aggregates. These materials are commonly used construction materials and frequently can be interchanged with one another. They are widely used throughout the United States, with every State except two producing crushed stone. Together they amount to about half the mining volume in the United States. Approximately 96 percent of sand and gravel and 77 percent of the crushed stone produced in the United States are used in the construction industry. Natural aggregates are widely distributed throughout the United States in a variety of geologic environments. Sand and gravel deposits commonly are the results of the weathering of bedrock and subsequent transportation and deposition of the material by water or ice (glaciers). As such, they commonly occur as river or stream deposits or in glaciated areas as glaciofluvial and other deposits. Crushed stone aggregates are derived from a wide variety of parent bedrock materials. Limestone and other carbonates account for approximately three quarters of the rocks used for crushed stone, with granite and other igneous rocks making up the bulk of the remainder. Limestone deposits are widespread throughout the Central and Eastern United States and are scattered in the West. Granites are widely distributed in the Eastern and Western United States, with few exposures in the Midwest. Igneous rocks (excluding granites) are largely concentrated in the Western United States and in a few isolated localities in the East. Even though natural aggregates are widely distributed throughout the United States, they are not universally available for consumptive use. Some areas are devoid of sand and gravel, and potential sources of crushed stone may be covered with sufficient unconsolidated material to make surface mining impractical. In some areas many aggregates do not meet the physical property requirements for certain uses, or they may contain mineral constituents that react

  17. Aggregation server for grid-integrated vehicles

    Science.gov (United States)

    Kempton, Willett

    2015-05-26

    Methods, systems, and apparatus for aggregating electric power flow between an electric grid and electric vehicles are disclosed. An apparatus for aggregating power flow may include a memory and a processor coupled to the memory to receive electric vehicle equipment (EVE) attributes from a plurality of EVEs, aggregate EVE attributes, predict total available capacity based on the EVE attributes, and dispatch at least a portion of the total available capacity to the grid. Power flow may be aggregated by receiving EVE operational parameters from each EVE, aggregating the received EVE operational parameters, predicting total available capacity based on the aggregated EVE operational parameters, and dispatching at least a portion of the total available capacity to the grid.

  18. Internal water curing with Liapor aggregates

    DEFF Research Database (Denmark)

    Lura, Pietro

    2005-01-01

    Internal water curing is a very efficient way to counteract self-desiccation and autogenous shrinkage in high performance concrete, thereby reducing the likelihood of early-age cracking. This paper deals with early-age volume changes and moisture transport in lightweight aggregate concrete realized...... with wet lightweight aggregates. Lightweight aggregate concrete mixtures with different degree of saturation and different particle size of the lightweight aggregates were studied and compared to normal weight concrete. Autogenous deformations, selfinduced stresses in fully restrained conditions, elastic...... modulus and compressive strength were measured. Early-age expansion of the mixtures was greater the higher the degree of the saturation of the lightweight aggregates and the finer their particle size. The elastic properties and the earlyage expansion of the lightweight aggregate concrete were calculated...

  19. Aggregate assessments support improved operational decision making

    International Nuclear Information System (INIS)

    Bauer, R.

    2003-01-01

    At Darlington Nuclear aggregate assessment of plant conditions is carried out in support of Operational Decision Making. This paper discusses how aggregate assessments have been applied to Operator Workarounds leading to improved prioritisation and alignment of work programs in different departments. As well, aggregate assessment of plant and human performance factors has been carried out to identify criteria which support conservative decision making in the main control room during unit transients. (author)

  20. A canonical representation for aggregated Markov processes

    OpenAIRE

    Larget, Bret

    1998-01-01

    A deterministic function of a Markov process is called an aggregated Markov process. We give necessary and sufficient conditions for the equivalence of continuous-time aggregated Markov processes. For both discrete- and continuous-time, we show that any aggregated Markov process which satisfies mild regularity conditions can be directly converted to a canonical representation which is unique for each class of equivalent models, and furthermore, is a minimal parameterization ...

  1. AN INTERACTIVE PROCEDURE FOR AGGREGATE PRODUCTION PLANNING

    OpenAIRE

    Nowak, Maciej

    2013-01-01

    Minimizing production cost over the planning period is usually assumed to be the objective of aggregate planning. However, other issues of strategic type may be even more important. Smoothing employment levels, driving down inventory levels or meeting high level of service usually are also considered. Thus, aggregate planning problem constitutes a multiple criteria decision making problem. In the paper a new approach for production aggregate planning problem is proposed. The procedure combine...

  2. Protein Aggregation Inhibitors for ALS Therapy

    Science.gov (United States)

    2013-07-01

    the underlying cause of protein misfolding and aggregation (oxidative stress damage ) and combating the aggregation caused by ROS that survive to...mechanisms of neuronal degeneration remain unknown in ALS, it has been postulated that protein misfolding and aggregation may be an early event that...of misfolded proteins . Of particular interest in this group is the proteasome ATPase, PSMC1. PSMC1 (also called Rpt2) has been reported to regulate

  3. Colloid release from soil aggregates

    DEFF Research Database (Denmark)

    Vendelboe, Anders Lindblad; Møldrup, Per; Schjønning, Per

    2012-01-01

    The content of water-dispersible colloids (WDC) has a major impact on soil functions and structural stability. In addition, the presence of mobile colloids may increase the risk of colloid-facilitated transport of strongly sorbing environmental contaminants. The WDC content was measured in 39 soils......, using laser diffraction, by agitating the samples using a wet-dispersion unit. This approach eliminated the need for long sedimentation times required by the more classical end-over-end shaking approach and provided information about the time-dependent release of WDC. The total clay content of the soils...... ranged from 0.1 to 0.44 kg kg−1. The WDC content was measured on air-dry and moist 1- to 2-mm aggregates. The WDC content at a reference time was highly correlated to the total clay content (r > 0.91, P soils. Only for two sites was the WDC content correlated to the content of clay...

  4. Familial Aggregation of Hyperemesis Gravidarum

    Science.gov (United States)

    Zhang, Yafeng; Cantor, Rita M.; Macgibbon, Kimber; Romero, Roberto; Goodwin, Thomas M.; Mullin, Patrick; Fejzo, Marlena S.

    2010-01-01

    Objective This study was undertaken to determine whether there is familial aggregation of Hyperemesis Gravidarum making it a disease amenable to genetic study. Study Design Cases with severe nausea and vomiting in a singleton pregnancy treated with intravenous hydration and unaffected friend controls completed a survey regarding family history. Results Sisters of women with Hyperemesis Gravidarum have a significantly increased risk of having Hyperemesis Gravidarum themselves (OR=17.3, p=0.005). Cases have a significantly increased risk of having a mother with severe nausea and vomiting; 33% of cases reported an affected mother compared to 7.7% of controls (pHyperemesis Gravidarum. This study provides strong evidence for a genetic component to hyperemesis gravidarum. Identification of the predisposing gene(s) may determine the cause of this poorly understood disease of pregnancy. PMID:20974461

  5. Quantifying aggregation dynamics during Myxococcus xanthus development.

    Science.gov (United States)

    Zhang, Haiyang; Angus, Stuart; Tran, Michael; Xie, Chunyan; Igoshin, Oleg A; Welch, Roy D

    2011-10-01

    Under starvation conditions, a swarm of Myxococcus xanthus cells will undergo development, a multicellular process culminating in the formation of many aggregates called fruiting bodies, each of which contains up to 100,000 spores. The mechanics of symmetry breaking and the self-organization of cells into fruiting bodies is an active area of research. Here we use microcinematography and automated image processing to quantify several transient features of developmental dynamics. An analysis of experimental data indicates that aggregation reaches its steady state in a highly nonmonotonic fashion. The number of aggregates rapidly peaks at a value 2- to 3-fold higher than the final value and then decreases before reaching a steady state. The time dependence of aggregate size is also nonmonotonic, but to a lesser extent: average aggregate size increases from the onset of aggregation to between 10 and 15 h and then gradually decreases thereafter. During this process, the distribution of aggregates transitions from a nearly random state early in development to a more ordered state later in development. A comparison of experimental results to a mathematical model based on the traffic jam hypothesis indicates that the model fails to reproduce these dynamic features of aggregation, even though it accurately describes its final outcome. The dynamic features of M. xanthus aggregation uncovered in this study impose severe constraints on its underlying mechanisms.

  6. Immunogenicity of therapeutic proteins: influence of aggregation.

    Science.gov (United States)

    Ratanji, Kirsty D; Derrick, Jeremy P; Dearman, Rebecca J; Kimber, Ian

    2014-01-01

    The elicitation of anti-drug antibodies (ADA) against biotherapeutics can have detrimental effects on drug safety, efficacy, and pharmacokinetics. The immunogenicity of biotherapeutics is, therefore, an important issue. There is evidence that protein aggregation can result in enhanced immunogenicity; however, the precise immunological and biochemical mechanisms responsible are poorly defined. In the context of biotherapeutic drug development and safety assessment, understanding the mechanisms underlying aggregate immunogenicity is of considerable interest. This review provides an overview of the phenomenon of protein aggregation, the production of unwanted aggregates during bioprocessing, and how the immune response to aggregated protein differs from that provoked by non-aggregated protein. Of particular interest is the nature of the interaction of aggregates with the immune system and how subsequent ADA responses are induced. Pathways considered here include 'classical' activation of the immune system involving antigen presenting cells and, alternatively, the breakdown of B-cell tolerance. Additionally, methods available to screen for aggregation and immunogenicity will be described. With an increased understanding of aggregation-enhanced immune responses, it may be possible to develop improved manufacturing and screening processes to avoid, or at least reduce, the problems associated with ADA.

  7. Detergent-mediated protein aggregation.

    Science.gov (United States)

    Neale, Chris; Ghanei, Hamed; Holyoake, John; Bishop, Russell E; Privé, Gilbert G; Pomès, Régis

    2013-04-01

    Because detergents are commonly used to solvate membrane proteins for structural evaluation, much attention has been devoted to assessing the conformational bias imparted by detergent micelles in comparison to the native environment of the lipid bilayer. Here, we conduct six 500-ns simulations of a system with >600,000 atoms to investigate the spontaneous self assembly of dodecylphosphocholine detergent around multiple molecules of the integral membrane protein PagP. This detergent formed equatorial micelles in which acyl chains surround the protein's hydrophobic belt, confirming existing models of the detergent solvation of membrane proteins. In addition, unexpectedly, the extracellular and periplasmic apical surfaces of PagP interacted with the headgroups of detergents in other micelles 85 and 60% of the time, respectively, forming complexes that were stable for hundreds of nanoseconds. In some cases, an apical surface of one molecule of PagP interacted with an equatorial micelle surrounding another molecule of PagP. In other cases, the apical surfaces of two molecules of PagP simultaneously bound a neat detergent micelle. In these ways, detergents mediated the non-specific aggregation of folded PagP. These simulation results are consistent with dynamic light scattering experiments, which show that, at detergent concentrations ≥600 mM, PagP induces the formation of large scattering species that are likely to contain many copies of the PagP protein. Together, these simulation and experimental results point to a potentially generic mechanism of detergent-mediated protein aggregation. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  8. Positive health-care effects of an alcohol ignition interlock programme among driving while impaired (DWI) offenders.

    Science.gov (United States)

    Bjerre, Bo; Kostela, Johan; Selén, Jan

    2007-11-01

    To compare the costs of hospital care and sick leave/disability pensions between two groups of driving while impaired (DWI) offenders: participants in an alcohol ignition interlock programme (AIIP) and controls with revoked licences, but with no comparable opportunity to participate in an AIIP. As an alternative to licence revocation DWI offenders can participate in a voluntary 2-year AIIP permitting the offender to drive under strict regulations entailing regular medical check-ups. The participants are forced to alter their alcohol habits and those who cannot demonstrate sobriety are dismissed from the programme. Participants are liable for all costs themselves. Quasi-experimental, with a non-equivalent control group used for comparison; intent-to-treat design. Based on the number of occasions/days in hospital and on sick leave/disability pension, the health-care costs for public insurance have been calculated. Average total health-care costs were 25% lower among AIIP participants (1156 individuals) than among controls (815 individuals) during the 2-year treatment period. This corresponds to over 1000 euros (SEK9610) less annual costs per average participant. For those who complete the 2-year programme the cost reduction was more pronounced; 37% during the treatment and 20% during the post-treatment period. The positive health-care effects were due apparently to reduced alcohol consumption. The social benefit of being allowed to drive while in the AIIP may also have contributed. The reduction in health-care costs was significant only during the 2-year treatment period, but among those who completed the entire AIIP sustained effects were also observed in the post-treatment period. The effects were comparable to those of regular alcoholism treatment programmes.

  9. Optimal location of a single distal interlocking screw in intramedullary nailing of distal third femoral shaft fractures.

    Science.gov (United States)

    George, C J; Lindsey, R W; Noble, P C; Alexander, J W; Kamaric, E

    1998-05-01

    This biomechanical study was done to determine the effect of the level of a single distal screw in a static intramedullary (IM) femoral nail on the stability of fixation of a fracture in the distal third of the femur. Fifteen composite fiberglass femora were osteotomized transversely in the distal third of the femur. A Grosse-Kempf nail was implanted into the femurs, which were divided into three groups of five specimens. Single screw distal nail locking was varied distal to the osteotomy site for each group at 2.5, 5.0, and 7.5 centimeters, respectively. All instrumented femurs were mounted on a servohydraulic testing machine and fitted with transducers to measure axial, rotational, and bending displacements. Specimens were cyclically loaded (one hertz) in simultaneous torsion (moment: +/- 10 newton-meters) and axial compression (amplitude: 2,000 newtons) for 500 cycles with a 250-pound abductor force. Data from linear and rotational transducers were sampled at 100 hertz for five cycles before cycling, every 100 cycles of loading, and immediately after cycling. Custom computer software was developed to convert transducer signals into static and dynamic measurements of axial motion (in millimeters), rotation (in degrees), and angulation (in degrees). Osteotomy site dynamic rotation increased significantly in specimens locked at 7.5 centimeters when compared with the 2.5-centimeter group. There was minimal difference between the stability of the 5.0-centimeter and 7.5-centimeter groups. There was no significant change in position at the fracture site before or after cyclic loading with respect to axial shortening, rotation, or bending. Both dynamic axial and angular displacements were also unaffected by screw position. The location of a single distal interlocking screw in static IM nail fixation of distal third femur fractures can significantly affect rotational stability but not axial or angular fixation.

  10. Morphological properties of atmospheric aerosol aggregates.

    Science.gov (United States)

    Xiong, C; Friedlander, S K

    2001-10-09

    Ultrafine particles (smaller than about 0.1 microm) are often emitted from combustion and other high-temperature processes in the form of fractal-like aggregates composed of solid nanoparticles. Results of a study of atmospheric aggregates are reported. Particles were collected on transmission electron microscope grids fitted on the last two stages of a single-jet eight-stage low-pressure impactor for periods of a few minutes. Photomicrographs of transmission electron microscope grids from the impactor stages were analyzed to obtain the fractal dimension (D(f)) and prefactor (A) for aggregates. D(f) increased from near 1 to above 2 as the number of primary particles making up the aggregates increased from 10 to 180. Total particle concentrations in size ranges roughly equivalent to the low-pressure impactor stages were measured with a mobility analyzer and condensation particle counter. In one set of measurements, the fraction of the particles present as aggregates was about 60% for particles with aerodynamic diameters between 50 and 75 nm and 34% for the range 75 to 120 nm. The total aggregate concentration in the 50- to 120-nm size range was about 400 ml(-1). The primary particles that make up atmospheric aggregates are more polydisperse than soot aggregates generated from a single laboratory source, an ethane/oxygen flame. Most measurements were made in the Los Angeles area, where the aggregates may represent a signature for diesel emissions. Rural aggregate concentrations in the size range 50 to 120 nm were less than 1% of the concentrations at urban sites. The data will permit better estimates of atmospheric aggregate residence times, transport, and deposition in the lung, optical extinction, and heterogeneous nucleation.

  11. Experimental fast reactor 'JOYO' MK-III function test. Interlock test of the primary and secondary cooling system and function test of the remote automatic fuel handling control system

    International Nuclear Information System (INIS)

    Michino, Masanobu; Suzuki, Toshiaki; Aita, Tsuyoshi

    2004-03-01

    This report describes the results of the primary and secondary cooling system interlock test and the fuel handling system function test, which were done as a part of JOYO MK-III function test. The items of the test are: (1) Primary and secondary cooling system interlock test (SKS-106,210). (2) Loss of electric power splay test (SKS-116). (3) In-vessel and ex-vessel automatic fuel transportation test (SKS-501, 502). As the interlock of the primary and secondary cooling system was changed, the interlock test by the reactor scram and the loss of electric power supply was carried out. The function of the remote automatic fuel handling system was confirmed before the handling of the fuel for MK-III core configuration. The results of the test satisfied the required performance, and it was confirmed that operation of the primary and secondary cooling system interlock and operation of the fuel handling system in JOYO MK-III were normal. (author)

  12. Impact of Particle Aggregation on Nanoparticle Reactivity

    Science.gov (United States)

    Jassby, David

    2011-12-01

    The prevalence of nanoparticles in the environment is expected to grow in the coming years due to their increasing pervasiveness in consumer and industrial applications. Once released into the environment, nanoparticles encounter conditions of pH, salinity, UV light, and other solution conditions that may alter their surface characteristics and lead to aggregation. The unique properties that make nanoparticles desirable are a direct consequence of their size and increased surface area. Therefore, it is critical to recognize how aggregation alters the reactive properties of nanomaterials, if we wish to understand how these properties are going to behave once released into the environment. The size and structure of nanoparticle aggregates depend on surrounding conditions, including hydrodynamic ones. Depending on these conditions, aggregates can be large or small, tightly packed or loosely bound. Characterizing and measuring these changes to aggregate morphology is important to understanding the impact of aggregation on nanoparticle reactive properties. Examples of decreased reactivity due to aggregation include the case where tightly packed aggregates have fewer available surface sites compared to loosely packed ones; also, photocatalytic particles embedded in the center of large aggregates will experience less light when compared to particles embedded in small aggregates. However, aggregation also results in an increase in solid-solid interfaces between nanoparticles. This can result in increased energy transfer between neighboring particles, surface passivation, and altered surface tension. These phenomena can lead to an increase in reactivity. The goal of this thesis is to examine the impacts of aggregation on the reactivity of a select group of nanomaterials. Additionally, we examined how aggregation impacts the removal efficiency of fullerene nanoparticles using membrane filtration. The materials we selected to study include ZnS---a metal chalcogenide

  13. RELATIONSHIPS BETWEEN SOIL MICROBIAL BIOMASS, AGGREGATE STABILITY AND AGGREGATE ASSOCIATED-C: A MECHANISTIC APPROACH

    Directory of Open Access Journals (Sweden)

    Patrizia Guidi

    2014-01-01

    Full Text Available For the identification of C pools involved in soil aggregation, a physically-based aggregate fractionation was proposed, and  additional pretreatments were used in the measurement of the 1-2 mm aggregate stability in order to elucidate the relevance of the role of soil microorganisms with respect to the different aggregate breakdown mechanisms. The study was carried out on three clay loam Regosols, developed on calcareous shales, known history of organic cultivation.Our results showed that the soil C pool controlling the process of stabilisation of aggregates was related to the microbial community. We identified the resistance to fast wetting as the major mechanism of aggregate stability driven by microorganims. The plausible hypothesis is that organic farming promotes fungi growth, improving water repellency of soil aggregates by fungal hydrophobic substances. By contrast, we failed in the identification of C pools controlling the formation of aggregates, probably because of the disturbance of mechanical tillage which contributes to the breakdown of soil aggregates.The physically-based aggregate fractionation proposed in this study resulted useful in the  mechanistically understanding of the role of microorganisms in soil aggregation and it might be suggested for studying the impact of management on C pools, aggregates properties and their relationships in agricultural soils.

  14. Aggregation and fibrillation of bovine serum albumin

    DEFF Research Database (Denmark)

    Holm, NK; Jespersen, SK; Thomassen, LV

    2007-01-01

    The all-alpha helix multi-domain protein bovine serum albumin (BSA) aggregates at elevated temperatures. Here we show that these thermal aggregates have amyloid properties. They bind the fibril-specific dyes Thioflavin T and Congo Red, show elongated although somewhat worm-like morphology...

  15. Teaching Aggregate Demand and Supply Models

    Science.gov (United States)

    Wells, Graeme

    2010-01-01

    The author analyzes the inflation-targeting model that underlies recent textbook expositions of the aggregate demand-aggregate supply approach used in introductory courses in macroeconomics. He shows how numerical simulations of a model with inflation inertia can be used as a tool to help students understand adjustments in response to demand and…

  16. Biomass round bales infield aggregation logistic scenarios

    Science.gov (United States)

    Biomass bales often need to be aggregated (collected into groups and transported) to a field-edge stack for temporary storage for feedlots or processing facilities. Aggregating the bales with the least total distance involved is a goal of producers and bale handlers. Several logistics scenarios for ...

  17. Reuse of industrial sludge as construction aggregates.

    Science.gov (United States)

    Tay, J H; Show, K Y; Hong, S Y

    2001-01-01

    Industrial wastewater sludge and dredged marine clay are high volume wastes that needed enormous space at landfill disposal sites. Due to the limitation of land space, there is an urgent need for alternative disposal methods for these two wastes. This study investigates the possibility of using the industrial sludge in combination with marine clay as construction aggregates. Different proportions of sludge and clay were made into round and angular aggregates. It was found that certain mix proportions could provide aggregates of adequate strength, comparable to that of conventional aggregates. Concrete samples cast from the sludge-clay aggregates yield compressive strengths in the range of 31.0 to 39.0 N/mm2. The results showed that the round aggregates of 100% sludge and the crush aggregates of sludge with up to 20% clay produced concrete of compressive strengths which are superior to that of 38.0 N/mm2 for conventional aggregate. The study indicates that the conversion of high volume wastes into construction materials is a potential option for waste management.

  18. Familial Aggregation and Childhood Blood Pressure

    NARCIS (Netherlands)

    Wang, Xiaoling; Xu, Xiaojing; Su, Shaoyong; Snieder, Harold

    There is growing concern about elevated blood pressure (BP) in children. The evidence for familial aggregation of childhood BP is substantial. Twin studies have shown that a large part of the familial aggregation of childhood BP is due to genes. The first part of this review provides the latest

  19. Aggregate stability in soils cultivated with eucalyptus

    Directory of Open Access Journals (Sweden)

    Junior Cesar Avanzi

    2011-01-01

    Full Text Available The objective of this work was to evaluate the aggregate stability of tropical soils under eucalyptus plantation and native vegetation, and assess the relationships between aggregate stability and some soil chemical and physical properties. Argisols, Cambisol, Latosols and Plinthosol within three eucalyptus-cultivated regions, in the states of Espírito Santo, Rio Grande do Sul and Minas Gerais, Brazil, were studied. For each region, soils under native vegetation were compared to those under minimum tillage with eucalyptus cultivation. The aggregate stability was measured using the high-energy moisture characteristic (HEMC technique, i.e., the moisture release curve at very low suctions. This method compares the resistance of aggregates to slaking on a relative scale from zero to one. Thus, the aggregate stability from different soils and management practices can be directly compared. The aggregate stability ratio was greater than 50% for all soils, which shows that the aggregate stability index is high, both in eucalyptus and native vegetation areas. This suggests that soil management adopted for eucalyptus cultivation does not substantially modify this property. In these soils, the aggregate stability ratio does not show a good relationship with clay or soil organic matter contents. However, soil organic matter shows a positive relationship with clay content and cation exchange capacity.

  20. Intricacies of alpha-synuclein aggregation

    NARCIS (Netherlands)

    Mucibabic, M.

    2016-01-01

    Parkinson’s disease is a neurodegenerative disease characterized by the presence of abnormal deposits of aggregated proteins in the brain tissue, known as Lewy bodies. The major components of Lewy bodies are aggregated forms of a small presynaptic protein known as α-synuclein (α-syn). In this thesis

  1. A vertically resolved model for phytoplankton aggregation

    Indian Academy of Sciences (India)

    Simple experiments demonstrate the effects of aggregation on the timing and depth distribution of primary production and export. A more detailed ecological model is applied to sites in the Arabian Sea; it demonstrates that aggregation can be important for deep sedimentation even when its effect on surface concentrations ...

  2. A vertically resolved model for phytoplankton aggregation

    Indian Academy of Sciences (India)

    This work presents models of the vertical distribution and flux of phytoplankton aggregates, including changes with time in the ... in the Arabian Sea; it demonstrates that aggregation can be important for deep sedimentation even when its effect on surface ... western parts, deep flux is strongly coupled to the increase in wind ...

  3. Comparative analysis of aggregate agricultural productivity between ...

    African Journals Online (AJOL)

    GREGORY

    2010-08-23

    Aug 23, 2010 ... The study compared the aggregate agricultural productivity between the Low External Input. Technology (LEIT) and ... Key words: Aggregate agricultural productivity, low and high external input technology farms. INTRODUCTION ... 2003). The realignment of the naira exchange rate, which resulted in the ...

  4. Protein aggregates stimulate macropinocytosis facilitating their propagation.

    Science.gov (United States)

    Yerbury, Justin J

    2016-03-03

    Temporal and spatial patterns of pathological changes such as loss of neurons and presence of pathological protein aggregates are characteristic of neurodegenerative diseases such as Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, Alzheimer's disease and Parkinson's disease. These patterns are consistent with the propagation of protein misfolding and aggregation reminiscent of the prion diseases. There is a surge of evidence that suggests that large protein aggregates of a range of proteins are able to enter cells via macropinocytosis. Our recent work suggests that this process is activated by the binding of aggregates to the neuron cell surface. The current review considers the potential role of cell surface receptors in the triggering of macropinocytosis by protein aggregates and the possibility of utilizing macropinocytosis pathways as a therapeutic target.

  5. Aggregation of sodium alkylbenzenesulfonates in aqueous solution

    Energy Technology Data Exchange (ETDEWEB)

    Magid, L.J.; Shaver, R.J.; Gulari, E.; Bedwell, B.; Alkhafaji, S.

    1981-01-01

    The surfactant 6 phenyl C/sub 12/SNa forms small spherical micelles in aqueous solution, having an aggregation number of 20 to 30 and a fractional charge of 0.45. These micelles are hydrated to the extent of approximately 18 moles H/sub 2/O per moles of surfactant. A second larger aggregate is also present in 6 phenyl C/sub 12/SNa solutions; its importance increases with solution age. Addition of NaCl causes both aggregates to apparently increase modestly in size. The surfactant 8 phenyl C/sub 16/SNa also contains both aggregates in its solutions; the larger one is relatively more important here. The larger aggregate does not correspond to dispersed bits of a liquid crystalline mesophase.

  6. Griseofulvin-induced aggregation of microtubule protein.

    Science.gov (United States)

    Roobol, A; Gull, K; Pogson, C I

    1977-01-01

    Griseofulvin (7-chloro-2',4,6-trimethoxy-6'-methylspiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione) induces aggregation of microtubule protein at 0 degrees C. This aggregate contains approx. 90% of the microtubule-associated proteins originally present in the microtubule protein. The supernatant obtained after removal of the griseofulvin-induced aggregate does not form microtubules on warming at 37 degrees C. Addition of the griseofulvin-aggregated protein to this supernatant and warming to 37 degrees C gives rise to a limited amount of microtubule assembly. The possible involvement of griseofulvin-induced aggregation of microtubule protein at 0 degrees C in the inhibition by griseofulvin of microtubule assembly in vitro is discussed. Images PLATE 1 PLATE 2 PMID:588267

  7. Ratio-Based Gradual Aggregation of Data

    DEFF Research Database (Denmark)

    Iftikhar, Nadeem

    2012-01-01

    cause data management and data storage issues. However, non-flexible and ineffective means of data aggregation not only reduce performance of database queries but also lead to erroneous reporting. This paper presents flexible and effective ratio-based methods for gradual data aggregation in databases....... Gradual data aggregation is a process that reduces data volume by converting the detailed data into multiple levels of summarized data as the data gets older. This paper also describes implementation strategies of the proposed methods based on standard database technology.......Majority of databases contain large amounts of data, gathered over long intervals of time. In most cases, the data is aggregated so that it can be used for analysis and reporting purposes. The other reason of data aggregation is to reduce data volume in order to avoid over-sized databases that may...

  8. Multicandidate Elections: Aggregate Uncertainty in the Laboratory.

    Science.gov (United States)

    Bouton, Laurent; Castanheira, Micael; Llorente-Saguer, Aniol

    2017-01-01

    The rational-voter model is often criticized on the grounds that two of its central predictions (the paradox of voting and Duverger's Law ) are at odds with reality. Recent theoretical advances suggest that these empirically unsound predictions might be an artifact of an (arguably unrealistic) assumption: the absence of aggregate uncertainty about the distribution of preferences in the electorate. In this paper, we propose direct empirical evidence of the effect of aggregate uncertainty in multicandidate elections. Adopting a theory-based experimental approach, we explore whether aggregate uncertainty indeed favors the emergence of non-Duverger's law equilibria in plurality elections. Our experimental results support the main theoretical predictions: sincere voting is a predominant strategy under aggregate uncertainty, whereas without aggregate uncertainty, voters massively coordinate their votes behind one candidate, who wins almost surely.

  9. Sans study of asphaltene aggregation

    Energy Technology Data Exchange (ETDEWEB)

    Overfield, R.E.; Sheu, E.Y.; Sinha, S.K.; Liang, K.S. (Esso Resources Canada Ltd., 339-50 Avenue S.E., Calgary, Alberta T2G 2B3 (CA))

    1988-06-01

    The colloidal properties of asphaltenes have long been recognized from peculiarities in their solubility and colligative properties. A layered micellar model or asphaltenes was proposed by others in which a highly condensed alkyl aromatic formed the central part, and molecules of decreasingly aromatic character (resins) clustered around them. Numerous studies, based on a variety of techniques such as ultracentrifugation and electron microscopy indicated a particulate nature for asphaltenes with size 20-40 A diameter. Others have proposed a refined model based on x-ray diffraction and small angle scattering. In this model, interactions between flat sheets of condensed aromatic rings form the central ''crystallite'' part of a spherical particle with the outer part being comprised of the aliphatic positions of the same molecules. These particles are bunched together with some degree of entanglement into ''micelles''. Concentration and solvent dependent radii of gyration, ranging from 30-50 A were reported. The aggregation creates a good deal of uncertainty as to the true molecular size or weight of asphaltenes. Neutron scattering offers novel contrast relative to light scattering (refractive index) and x-ray scattering (electron density). This is because the scattering length of proton is negative, whereas that from deuterium and other nuclei such as C, S, O, and N are positive. Thus by replacing hydrogen with deuterium in either the solvent or the scatterer the contrast can be varied, and different parts of the molecule can be highlighted.

  10. Aggregation of volcanic ash in explosive eruptions

    Science.gov (United States)

    Telling, J. W.; Dufek, J.

    2009-12-01

    We present the result of a recent experimental and numerical investigation of ash aggregation in volcanic plumes. Eruption dynamics are sensitive to microphysical processes, like ash aggregation, yet are difficult to parameterize based on dynamics simulations of whole eruption columns due to the lack of sufficient resolution. Here we present the results of experiments that develop a probabilistic relationship for ash aggregation based on impact velocity and atmospheric conditions (water vapor and atmospheric pressure). The probabilistic relationship can be integrated, in conjunction with a reconstructed velocity distribution of the ash in the column, and then can be readily incorporated in large-scale simulations of eruption column behavior. We also conduct detailed Eulerian-Lagrangian simulations at the scale of our experiment as a test of the ash aggregation relationship. The physical experiment was carried out in a contained tank designed to allow for the control of ‘atmospheric’ conditions. The tank can be depressurized as needed, using the gas inlet and the attached vacuum pump, and the ambient humidity can be altered by adjusting the gas mixture at the inlet. Image data is recorded with a high speed camera and post-processed to determine the number of collisions, energy of collisions and probability of aggregation. We will present the results of aggregation probability and the effects of incorporating these results into a multiphase model of a three-dimensional eruption column, where the effects of ash aggregation are especially important in regions of high shear and high granular temperature.

  11. Microbial Ecology of Soil Aggregation in Agroecosystems

    Science.gov (United States)

    Hofmockel, K. S.; Bell, S.; Tfailly, M.; Thompson, A.; Callister, S.

    2017-12-01

    Crop selection and soil texture influence the physicochemical attributes of the soil, which structures microbial communities and influences soil C cycling storage. At the molecular scale, microbial metabolites and necromass alter the soil environment, which creates feedbacks that influence ecosystem functions, including soil C accumulation. By integrating lab to field studies we aim to identify the molecules, organisms and metabolic pathways that control carbon cycling and stabilization in bioenergy soils. We investigated the relative influence of plants, microbes, and minerals on soil aggregate ecology at the Great Lakes Bioenergy Research experiment. Sites in WI and MI, USA have been in corn and switchgrass cropping systems for a decade. By comparing soil aggregate ecology across sites and cropping systems we are able to test the relative importance of plant, microbe, mineral influences on soil aggregate dynamics. Soil microbial communities (16S) differ in diversity and phylogeny among sites and cropping systems. FT-ICR MS revealed differences in the molecular composition of water-soluble fraction of soil organic matter for cropping systems and soil origin for both relative abundance of assigned formulas and biogeochemical classes of compounds. We found the degree of aggregation, measured by mean weighted diameter of aggregate fractions, is influenced by plant-soil interactions. Similarly, the proportion of soil aggregate fractions varied by both soil and plant factors. Differences in aggregation were reflected in differences in bacterial, but not fungal community composition across aggregate fractions, within each soil. Scanning electron microscopy revealed stark differences in mineral-organic interactions that influence the microbial niche and the accessibility of substrates within the soil. The clay soils show greater surface heterogeneity, enabling interactions with organic fraction of the soil. This is consistent with molecular data that reveal differences

  12. Insulin aggregation tracked by its intrinsic TRES

    Science.gov (United States)

    Chung, Li Hung C.; Birch, David J. S.; Vyshemirsky, Vladislav; Ryadnov, Maxim G.; Rolinski, Olaf J.

    2017-12-01

    Time-resolved emission spectra (TRES) have been used to detect conformational changes of intrinsic tyrosines within bovine insulin at a physiological pH. The approach offers the ability to detect the initial stages of insulin aggregation at the molecular level. The data analysis has revealed the existence of at least three fluorescent species undergoing dielectric relaxation and significant spectral changes due to insulin aggregation. The results indicate the suitability of the intrinsic TRES approach for insulin studies and for monitoring its stability during storage and aggregation in insulin delivery devices.

  13. Path coupling and aggregate path coupling

    CERN Document Server

    Kovchegov, Yevgeniy

    2018-01-01

    This book describes and characterizes an extension to the classical path coupling method applied to statistical mechanical models, referred to as aggregate path coupling. In conjunction with large deviations estimates, the aggregate path coupling method is used to prove rapid mixing of Glauber dynamics for a large class of statistical mechanical models, including models that exhibit discontinuous phase transitions which have traditionally been more difficult to analyze rigorously. The book shows how the parameter regions for rapid mixing for several classes of statistical mechanical models are derived using the aggregate path coupling method.

  14. Programming spiders, bots, and aggregators in Java

    CERN Document Server

    Heaton, Jeff

    2006-01-01

    The content and services available on the web continue to be accessed mostly through direct human control. But this is changing. Increasingly, users rely on automated agents that save them time and effort by programmatically retrieving content, performing complex interactions, and aggregating data from diverse sources. Programming Spiders, Bots, and Aggregators in Java teaches you how to build and deploy a wide variety of these agents-from single-purpose bots to exploratory spiders to aggregators that present a unified view of information from multiple user accounts. You will quickly build on

  15. Synchronized Data Aggregation for Wireless Sensor Network

    DEFF Research Database (Denmark)

    Dnyaneshwar, Mantri; Prasad, Neeli R.; Prasad, Ramjee

    2014-01-01

    Wireless Sensor Networks (WSNs) are used for monitoring and data collection purposes. A key challenge in effective data collection is to schedule and synchronize the activities of the nodes with global clock. This paper proposes the Synchronized Data Aggregation Algorithm (SDA) using spanning tree...... mechanism. It provides network-wide time synchronization for sensor network. In the initial stage algorithm established the hierarchical structure in the network and then perform the pair - wise synchronization. SDA aggregate data with a global time scale throughout the network. The aggregated packets...

  16. Reusing recycled aggregates in structural concrete

    Science.gov (United States)

    Kou, Shicong

    The utilization of recycled aggregates in concrete can minimize environmental impact and reduce the consumption of natural resources in concrete applications. The aim of this thesis is to provide a scientific basis for the possible use of recycled aggregates in structure concrete by conducting a comprehensive programme of laboratory study to gain a better understanding of the mechanical, microstructure and durability properties of concrete produced with recycled aggregates. The study also explored possible techniques to of improve the properties of recycled aggregate concrete that is produced with high percentages (≧ 50%) of recycled aggregates. These techniques included: (a) using lower water-to-cement ratios in the concrete mix design; (b) using fly ash as a cement replacement or as an additional mineral admixture in the concrete mixes, and (c) precasting recycled aggregate concrete with steam curing regimes. The characteristics of the recycled aggregates produced both from laboratory and a commercially operated pilot construction and demolition (C&D) waste recycling plant were first studied. A mix proportioning procedure was then established to produce six series of concrete mixtures using different percentages of recycled coarse aggregates with and without the use of fly ash. The water-to-cement (binder) ratios of 0.55, 0.50, 0.45 and 0.40 were used. The fresh properties (including slump and bleeding) of recycled aggregate concrete (RAC) were then quantified. The effects of fly ash on the fresh and hardened properties of RAC were then studied and compared with those RAC prepared with no fly ash addition. Furthermore, the effects of steam curing on the hardened properties of RAC were investigated. For micro-structural properties, the interfacial transition zones of the aggregates and the mortar/cement paste were analyzed by SEM and EDX-mapping. Moreover, a detailed set of results on the fracture properties for RAC were obtained. Based on the experimental

  17. An exact approach for aggregated formulations

    DEFF Research Database (Denmark)

    Gamst, Mette; Spoorendonk, Simon

    Aggregating formulations is a powerful approach for transforming problems into taking more tractable forms. Aggregated formulations can, though, have drawbacks: some information may get lost in the aggregation and { put in a branch-and-bound context { branching may become very di_cult and even....... The paper includes general considerations on types of problems for which the method is of particular interest. Furthermore, we prove the correctness of the procedure and consider how to include extensions such as cutting planes and advanced branching strategies....

  18. Treatment of comminuted tibial shaft fractures in four dogs with the use of interlocking nail connected with type I external fixator.

    Science.gov (United States)

    Piórek, A; Adamiak, Z; Jaskólska, M; Zhalniarovich, Y

    2012-01-01

    The treatment of comminuted tibial shaft fractures in canine patients is burdened by significant risk which involves bone healing complications, such as delayed bone union. Complications may result from iatrogenic damage to blood vessels during fracture stabilization. To minimize this risk, treatment methods increasingly often rely on the concept of biological osteosynthesis. One of such methods involves the treatment of fractures with the use of new hybrid fixator consisted of an interlocking nail connected with type I external fixator. Connection of the nail with external fixator has been recently developed to maximize treatment efficiency. This manner of stabilization increases bone-fixator construct strength on forces acting in the place of fracture. It also enables fracture fixation with minimal damage of the blood supply of bone fragments. This article describes surgical procedure of stabilization of comminuted tibial bone fractures in four dogs by the use of interlocking nail connected with external fixator type I, discusses and evaluates the results of clinical treatment with the involvement of the said fixator. To control bone consolidation process the radiograms were taken in 6 and 8 week of healing. In all cases, the reviewed methods of clinical treatment were successful in producing bone union after eight week of healing. During the whole period of observations no complication was observed. In all cases the intramedullary nail were left in the medullary canal after the healing process was finished. The fixator supported quick restoration of limb function after treatment.

  19. Implementation of a Direct Link between the LHC Beam Interlock System and the LHC Beam Dumping System Re-Triggering Lines

    CERN Document Server

    Gabourin, S; Denz, R; Magnin, N; Uythoven, J; Wollmann, D; Zerlauth, M; Vatansever, V; Bartholdt, M; Bertsche, B; Zeiler, P

    2014-01-01

    To avoid damage of accelerator equipment due to impacting beam, the controlled removal of the LHC beams from the collider rings towards the dump blocks must be guaranteed at all times. When a beam dump is demanded, the Beam Interlock System communicates this request to the Trigger Synchronisation and Distribution System of the LHC Beam Dumping System. Both systems were built according to high reliability standards. To further reduce the risk of incapability to dump the beams in case of correlated failures in the Trigger Synchronisation and Distribution System, a new direct link from the Beam Interlock System to the re-triggering lines of the LHC Beam Dumping System will be implemented for the start-up with beam in 2015. The link represents a diverse redundancy to the current implementation, which should neither significantly increase the risk for so-called asynchronous beam dumps nor compromise machine availability. This paper describes the implementation choices of this link. Furthermore the results of a rel...

  20. Use of expanded clay aggregate in bituminous construction.

    Science.gov (United States)

    1959-01-01

    In an effort to find a solution to the shortage of aggregate, for use in highway construction, Louisiana Department of Highways initiated a study. : In early 1955, we started experimenting with expanded aggregate or lightweight aggregate as commonly ...

  1. p53 Aggregates penetrate cells and induce the co-aggregation of intracellular p53.

    Directory of Open Access Journals (Sweden)

    Karolyn J Forget

    Full Text Available Prion diseases are unique pathologies in which the infectious particles are prions, a protein aggregate. The prion protein has many particular features, such as spontaneous aggregation, conformation transmission to other native PrP proteins and transmission from an individual to another. Protein aggregation is now frequently associated to many human diseases, for example Alzheimer's disease, Parkinson's disease or type 2 diabetes. A few proteins associated to these conformational diseases are part of a new category of proteins, called prionoids: proteins that share some, but not all, of the characteristics associated with prions. The p53 protein, a transcription factor that plays a major role in cancer, has recently been suggested to be a possible prionoid. The protein has been shown to accumulate in multiple cancer cell types, and its aggregation has also been reproduced in vitro by many independent groups. These observations suggest a role for p53 aggregates in cancer development. This study aims to test the «prion-like» features of p53. Our results show in vitro aggregation of the full length and N-terminally truncated protein (p53C, and penetration of these aggregates into cells. According to our findings, the aggregates enter cells using macropinocytosis, a non-specific pathway of entry. Lastly, we also show that once internalized by the cell, p53C aggregates can co-aggregate with endogenous p53 protein. Together, these findings suggest prion-like characteristics for p53 protein, based on the fact that p53 can spontaneously aggregate, these aggregates can penetrate cells and co-aggregate with cellular p53.

  2. Geopolymerization of lightweight aggregate waste

    Directory of Open Access Journals (Sweden)

    Labrincha, J. A.

    2008-09-01

    Full Text Available Geopolymerization is a viable way to process and re-use alumino-silicate industrial waste while producing highstrength, high chemical inertia materials that can effectively immobilize other industrial by-products, and even hazardous waste. In this study industrial waste from different stages of the manufacture of lightweight expanded clay aggregate was characterized for its possible transformation, via alkali activation, to geopolymers. The ultimate aim was to assess the possibility of using such geopolymers to develop thermal and acoustic insulation panels. The containment of hazardous materials is another important application for these new materials. Geopolymers were prepared for this study with different particles size distributions and activator concentrations. Their mechanical properties, composition and microstructure were characterized and a material with promising insulating properties was produced. A preliminary analysis was conducted of the salt formation observed in these geopolymers, the chief drawback to their use.La geopolimerización es una manera viable para procesar y agregar valor a los residuos industriales de alumino-silicato dando lugar a materiales con elevadas resistencias mecánmicas, alta inercia química y que permiten encapsular otros residuos, incluso peligrosos. Los residuos industriales que proceden de diversos tipos de arcillas para la fabricación de áridos ligeros se han caracterizado para la producción de geopolímeros mediante el proceso de ataque alcalino. Su incorporación en una matriz geopolimérica permite la posibilidad de desarrollo de paneles de aislamiento (térmico y acústico. Además, la inmovilización de materiales peligrosos es un logro adicional importante. Los geopolímeros se han producido con fórmulas diferentes y se han caracterizado sus propiedades mecánicas, composición y microestructura, para dar lugar a una composición interesante con propiedades aislantes. Se ha llevado a cabo

  3. Alkali-aggregate reactivity (AAR) facts book.

    Science.gov (United States)

    2013-03-01

    This document provides detailed information on alkali-aggregate reactivity (AAR). It primarily discusses alkali-silica reaction (ASR), covering the chemistry, symptoms, test methods, prevention, specifications, diagnosis and prognosis, and mitigation...

  4. GPP Webinar: The Power of Aggregated Purchasing

    Science.gov (United States)

    Green Power Partnership webinar examining the use of an aggregated model for renewable energy purchases which can lead to significant energy, environmental and financial benefits by addressing administrative cost barriers and leveraging the shared purchasi

  5. Model of fractal aggregates induced by shear

    Directory of Open Access Journals (Sweden)

    Wan Zhanhong

    2013-01-01

    Full Text Available It is an undoubted fact that particle aggregates from marine, aerosol, and engineering systems have fractal structures. In this study, fractal geometry is used to describe the morphology of irregular aggregates. The mean-field theory is employed to solve coagulation kinetic equation of aggregates. The Taylor-expansion method of moments in conjunction with the self-similar fractal characteristics is used to represent the particulate field. The effect of the target fractal dimensions on zeroth-order moment, second-order moment, and geometric standard deviation of the aggregates is explored. Results show that the developed moment method is an efficient and powerful approach to solving such evolution equations.

  6. Modeling In-Network Aggregation in VANETs

    NARCIS (Netherlands)

    Dietzel, Stefan; Kargl, Frank; Heijenk, Geert; Schaub, Florian

    2011-01-01

    The multitude of applications envisioned for vehicular ad hoc networks requires efficient communication and dissemination mechanisms to prevent network congestion. In-network data aggregation promises to reduce bandwidth requirements and enable scalability in large vehicular networks. However, most

  7. HDR-Aggregate Read Service (ARS)

    Data.gov (United States)

    Department of Veterans Affairs — ARS is a SOAP web service exposed over HTTPS that provides an aggregated (report) view of HTH Survey, DMP and Census data stored in the HDR DB. ARS is deployed in...

  8. Concretes with red mud coarse aggregates

    Directory of Open Access Journals (Sweden)

    Dênio Ramam Carvalho de Oliveira

    2012-06-01

    Full Text Available Red mud (RM is a mineral waste, residue of the Bayer process used to obtain alumina from bauxite. While the exploration of rolled pebble damages the environment and is much more controlled by the government, the huge RM disposal areas do not stop increasing and polluting soil, rivers and groundwater sources in Amazon. In this work, the material mixtures used to produce coarse aggregates presented up to 80% of RM, 30% of metakaolin and 30% of active silica as recycled waste. Several tests were carried out to determine the aggregates physical properties and to evaluate the mechanical performance of the concretes with the new aggregates, including hydraulic abrasion strength, and the results were compared to the reference ones, i.e. rolled pebble concretes. Additionally, the sintering process neutralizes any toxic substance as occur in some RM products like tiles and bricks, and these results have encouraged an industrial or semi-industrial production of RM aggregates for concretes.

  9. Suspensions of colloidal particles and aggregates

    CERN Document Server

    Babick, Frank

    2016-01-01

    This book addresses the properties of particles in colloidal suspensions. It has a focus on particle aggregates and the dependency of their physical behaviour on morphological parameters. For this purpose, relevant theories and methodological tools are reviewed and applied to selected examples. The book is divided into four main chapters. The first of them introduces important measurement techniques for the determination of particle size and interfacial properties in colloidal suspensions. A further chapter is devoted to the physico-chemical properties of colloidal particles—highlighting the interfacial phenomena and the corresponding interactions between particles. The book’s central chapter examines the structure-property relations of colloidal aggregates. This comprises concepts to quantify size and structure of aggregates, models and numerical tools for calculating the (light) scattering and hydrodynamic properties of aggregates, and a discussion on van-der-Waals and double layer interactions between ...

  10. Fish Aggregation Sites in the Florida Keys

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Spawning aggregations are an important event in the life-history of many coral reef fish species. During short time periods (typically during full moons), fish will...

  11. Aggregation of rat neutrophils by nucleotide triphosphates.

    OpenAIRE

    Ford-Hutchinson, A. W.

    1982-01-01

    1 Adenosine 5'-triphosphate (ATP) and uridine 5'-triphosphate (UTP) at concentrations of 3 x 10(-7)M and greater cause a rapid partially reversible aggregation of rat polymorphonuclear leucocytes. 2 Other nucleotide phosphates are much less active at producing aggregation responses; the agonist potencies being UTP greater than ATP greater than guanosine 5'-triphosphate, cytidine 5'-triphosphate, thymidine 5'-triphosphate; ATP greater than adenosine 5'-diphosphate (ADP) greater than adenosine ...

  12. Photoacoustic signal amplification through plasmonic nanoparticle aggregation

    OpenAIRE

    Bayer, Carolyn L.; Nam, Seung Yun; Chen, Yun-Sheng; Emelianov, Stanislav Y.

    2013-01-01

    Photoacoustic imaging, using targeted plasmonic metallic nanoparticles, is a promising noninvasive molecular imaging method. Analysis of the photoacoustic signal generated by plasmonic metallic nanoparticles is complex because of the dependence upon physical properties of both the nanoparticle and the surrounding environment. We studied the effect of the aggregation of gold nanoparticles on the photoacoustic signal amplitude. We found that the photoacoustic signal from aggregated silica-coate...

  13. Ash aggregation in explosive volcanic eruptions

    Science.gov (United States)

    Telling, J. W.; Dufek, J.

    2010-12-01

    We present the result of a recent experimental and numerical investigation of ash aggregation in volcanic plumes. Eruption dynamics are sensitive to microphysical processes, like ash aggregation, yet are difficult to parameterize based on dynamics simulations of whole eruption columns due to the lack of sufficient resolution. Here we present the results of experiments that develop a probabilistic relationship for ash aggregation based on particle size, collisional energy and atmospheric water vapor. These relationships can be integrated into large-scale simulations of eruption column behavior in conjunction with a reconstructed velocity distribution of the ash in the column. The physical experiment was carried out in a contained tank designed to allow for the control of atmospheric water vapor. Image data is recorded with a high speed camera and post-processed to determine the number of collisions, energy of collisions and probability of aggregation. We will present the results of aggregation probability and the effects of incorporating these results into a multiphase model of a three-dimensional eruption column, where the effects of ash aggregation are especially important in regions of high shear and high granular temperature.

  14. Growth hormone aggregates in the rat adenohypophysis

    Science.gov (United States)

    Farrington, M.; Hymer, W. C.

    1990-01-01

    Although it has been known for some time that GH aggregates are contained within the rat anterior pituitary gland, the role that they might play in pituitary function is unknown. The present study examines this issue using the technique of Western blotting, which permitted visualization of 11 GH variants with apparent mol wt ranging from 14-88K. Electroelution of the higher mol wt variants from gels followed by their chemical reduction with beta-mercaptoethanol increased GH immunoassayability by about 5-fold. With the blot procedure we found 1) that GH aggregates greater than 44K were associated with a 40,000 x g sedimentable fraction; 2) that GH aggregates were not present in glands from thyroidectomized rats, but were in glands from the thyroidectomized rats injected with T4; 3) that GH aggregates were uniquely associated with a heavily granulated somatotroph subpopulation isolated by density gradient centrifugation; and 4) that high mol wt GH forms were released from the dense somatotrophs in culture, since treatment of the culture medium with beta-mercaptoethanol increased GH immunoassayability by about 5-fold. Taken together, the results show that high mol wt GH aggregates are contained in secretory granules of certain somatotrophs and are also released in aggregate form from these cells in vitro.

  15. Structure-based inhibitors of tau aggregation

    Science.gov (United States)

    Seidler, P. M.; Boyer, D. R.; Rodriguez, J. A.; Sawaya, M. R.; Cascio, D.; Murray, K.; Gonen, T.; Eisenberg, D. S.

    2018-02-01

    Aggregated tau protein is associated with over 20 neurological disorders, which include Alzheimer's disease. Previous work has shown that tau's sequence segments VQIINK and VQIVYK drive its aggregation, but inhibitors based on the structure of the VQIVYK segment only partially inhibit full-length tau aggregation and are ineffective at inhibiting seeding by full-length fibrils. Here we show that the VQIINK segment is the more powerful driver of tau aggregation. Two structures of this segment determined by the cryo-electron microscopy method micro-electron diffraction explain its dominant influence on tau aggregation. Of practical significance, the structures lead to the design of inhibitors that not only inhibit tau aggregation but also inhibit the ability of exogenous full-length tau fibrils to seed intracellular tau in HEK293 biosensor cells into amyloid. We also raise the possibility that the two VQIINK structures represent amyloid polymorphs of tau that may account for a subset of prion-like strains of tau.

  16. Paper Sludge Reuse in Lightweight Aggregates Manufacturing.

    Science.gov (United States)

    Chen, How-Ji; Hsueh, Ying-Chih; Peng, Ching-Fang; Tang, Chao-Wei

    2016-10-27

    The lightweight aggregates used by the civil engineering market are sintered at a high temperature, about 1200 °C. In times of high energy prices and regulation of carbon dioxide emissions, lightweight aggregate products of the high-temperature process in sales marketing are not readily accepted. This study developed a sintered-type paper sludge lightweight aggregate. In order to reduce energy consumption, substitution of some reservoir sediment clay in paper sludge substitutes is to be expected. The study used two types of paper sludge (green clay paper sludge and paper pulp sludge). The sintering temperature was reduced effectively as the green clay paper sludge was substituted for some of the reservoir sediment clay, and the optimum substitute ranges of green clay paper sludge were 10%-50%. The optimum substitute ranges of the paper pulp sludge were 10%-40%. Test results show that the properties of aggregates have a particle density of 0.66-1.69 g/cm³, a water absorption of 5%-30%, and a loss on ignition of 10%-43%. The loss on ignition of aggregate became greater with the increase in paper sludge content. This means that the calorific value provided by the paper sludge will increase as paper sludge content increases. Paper sludge can therefore be considered a good material to provide heat energy for sintering lightweight aggregate.

  17. A Novel Method to Quantify Soil Aggregate Stability by Measuring Aggregate Bond Energies

    Science.gov (United States)

    Efrat, Rachel; Rawlins, Barry G.; Quinton, John N.; Watts, Chris W.; Whitmore, Andy P.

    2016-04-01

    Soil aggregate stability is a key indicator of soil quality because it controls physical, biological and chemical functions important in cultivated soils. Micro-aggregates are responsible for the long term sequestration of carbon in soil, therefore determine soils role in the carbon cycle. It is thus vital that techniques to measure aggregate stability are accurate, consistent and reliable, in order to appropriately manage and monitor soil quality, and to develop our understanding and estimates of soil as a carbon store to appropriately incorporate in carbon cycle models. Practices used to assess the stability of aggregates vary in sample preparation, operational technique and unit of results. They use proxies and lack quantification. Conflicting results are therefore drawn between projects that do not provide methodological or resultant comparability. Typical modern stability tests suspend aggregates in water and monitor fragmentation upon exposure to an un-quantified amount of ultrasonic energy, utilising a laser granulometer to measure the change in mean weight diameter. In this project a novel approach has been developed based on that of Zhu et al., (2009), to accurately quantify the stability of aggregates by specifically measuring their bond energies. The bond energies are measured operating a combination of calorimetry and a high powered ultrasonic probe, with computable output function. Temperature change during sonication is monitored by an array of probes which enables calculation of the energy spent heating the system (Ph). Our novel technique suspends aggregates in heavy liquid lithium heteropolytungstate, as opposed to water, to avoid exposing aggregates to an immeasurable disruptive energy source, due to cavitation, collisions and clay swelling. Mean weight diameter is measured by a laser granulometer to monitor aggregate breakdown after successive periods of calculated ultrasonic energy input (Pi), until complete dispersion is achieved and bond

  18. Metaconcrete: Engineered aggregates for enhanced dynamic performance

    Science.gov (United States)

    Mitchell, Stephanie J.

    This work presents the development and investigation of a new type of concrete for the attenuation of waves induced by dynamic excitation. Recent progress in the field of metamaterials science has led to a range of novel composites which display unusual properties when interacting with electromagnetic, acoustic, and elastic waves. A new structural metamaterial with enhanced properties for dynamic loading applications is presented, which is named metaconcrete. In this new composite material the standard stone and gravel aggregates of regular concrete are replaced with spherical engineered inclusions. Each metaconcrete aggregate has a layered structure, consisting of a heavy core and a thin compliant outer coating. This structure allows for resonance at or near the eigenfrequencies of the inclusions, and the aggregates can be tuned so that resonant oscillations will be activated by particular frequencies of an applied dynamic loading. The activation of resonance within the aggregates causes the overall system to exhibit negative effective mass, which leads to attenuation of the applied wave motion. To investigate the behavior of metaconcrete slabs under a variety of different loading conditions a finite element slab model containing a periodic array of aggregates is utilized. The frequency dependent nature of metaconcrete is investigated by considering the transmission of wave energy through a slab, which indicates the presence of large attenuation bands near the resonant frequencies of the aggregates. Applying a blast wave loading to both an elastic slab and a slab model that incorporates the fracture characteristics of the mortar matrix reveals that a significant portion of the supplied energy can be absorbed by aggregates which are activated by the chosen blast wave profile. The transfer of energy from the mortar matrix to the metaconcrete aggregates leads to a significant reduction in the maximum longitudinal stress, greatly improving the ability of the material

  19. 21 CFR 864.5700 - Automated platelet aggregation system.

    Science.gov (United States)

    2010-04-01

    ... addition of an aggregating reagent to a platelet-rich plasma. (b) Classification. Class II (performance... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Automated platelet aggregation system. 864.5700... § 864.5700 Automated platelet aggregation system. (a) Identification. An automated platelet aggregation...

  20. Aspects Concerning the Use of Recycled Concrete Aggregates

    Science.gov (United States)

    Robu, I.; Mazilu, C.; Deju, R.

    2016-11-01

    Natural aggregates (gravel and crushed) are essential non-renewable resources which are used for infrastructure works and civil engineering. Using recycled concrete aggregates (RCA) is a matter of high priority in the construction industry worldwide. This paper presents a study on the use of recycled aggregates, from a concrete of specified class, to acquire new cement concrete with different percentages of recycled aggregates.

  1. Use of hydroxyethyl starch for inducing red blood cell aggregation

    NARCIS (Netherlands)

    Henkelman, Sandra; Rakhorst, Gerhard; van der Mei, Henny C.; Busscher, Henk J.

    2012-01-01

    Aggregation of human red blood cells (RBC) remains of biological and clinical interest. Replacement of plasma proteins by polymers to induce RBC aggregation may help to unravel the fundamentals of the aggregation process. Two theories exist to explain RBC aggregation mechanisms: a depletion and a

  2. Molecular chaperones antagonize proteotoxicity by differentially modulating protein aggregation pathways

    OpenAIRE

    Douglas, Peter M; Summers, Daniel W; Cyr, Douglas M

    2009-01-01

    The self-association of misfolded or damaged proteins into ordered amyloid-like aggregates characterizes numerous neurodegenerative disorders. Insoluble amyloid plaques are diagnostic of many disease states. Yet soluble, oligomeric intermediates in the aggregation pathway appear to represent the toxic culprit. Molecular chaperones regulate the fate of misfolded proteins and thereby influence their aggregation state. Chaperones conventionally antagonize aggregation of misfolded, disease protei...

  3. Soil aggregation under different management systems

    Directory of Open Access Journals (Sweden)

    Cibele Mascioli Rebello Portella

    2012-12-01

    Full Text Available Considering that the soil aggregation reflects the interaction of chemical, physical and biological soil factors, the aim of this study was evaluate alterations in aggregation, in an Oxisol under no-tillage (NT and conventional tillage (CT, since over 20 years, using as reference a native forest soil in natural state. After analysis of the soil profile (cultural profile in areas under forest management, samples were collected from the layers 0-5, 5-10, 10-20 and 20-40 cm, with six repetitions. These samples were analyzed for the aggregate stability index (ASI, mean weighted diameter (MWD, mean geometric diameter (MGD in the classes > 8, 8-4, 4-2, 2-1, 1-0.5, 0.5-0.25, and < 0.25 mm, and for physical properties (soil texture, water dispersible clay (WDC, flocculation index (FI and bulk density (Bd and chemical properties (total organic carbon - COT, total nitrogen - N, exchangeable calcium - Ca2+, and pH. The results indicated that more intense soil preparation (M < NT < PC resulted in a decrease in soil stability, confirmed by all stability indicators analyzed: MWD, MGD, ASI, aggregate class distribution, WDC and FI, indicating the validity of these indicators in aggregation analyses of the studied soil.

  4. Modifiers of mutant huntingtin aggregation : Functional conservation of C. elegans-modifiers of polyglutamine aggregation

    NARCIS (Netherlands)

    Teuling, Eva; Bourgonje, Annika; Veenje, Sven; Thijssen, Karen; de Boer, Jelle; van der Velde, Joeri; Swertz, Morris; Nollen, Ellen

    2011-01-01

    Protein aggregation is a common hallmark of a number of age-related neurodegenerative diseases, including Alzheimer's, Parkinson's, and polyglutamine-expansion disorders such as Huntington's disease, but how aggregation-prone proteins lead to pathology is not known. Using a genome-wide RNAi screen

  5. Soil aggregation and aggregating agents as affected by long term contrasting management of an Anthrosol

    Science.gov (United States)

    Zhang, Shulan; Wang, Renjie; Yang, Xueyun; Sun, Benhua; Li, Qinghui

    2016-12-01

    Soil aggregation was studied in a 21-year experiment conducted on an Anthrosol. The soil management regimes consisted of cropland abandonment, bare fallow without vegetation and cropping system. The cropping system was combined with the following nutrient management treatments: control (CONTROL, no nutrient input); nitrogen, phosphorus and potassium (NPK); straw plus NPK (SNPK); and manure (M) plus NPK (MNPK). Compared with the CONTROL treatment, the abandonment treatment significantly increased the formation of large soil macroaggregates (>2 mm) and consequently improved the stability of aggregates in the surface soil layer due to enhancement of hyphal length and of soil organic matter content. However, in response to long-term bare fallow treatment aggregate stability was low, as were the levels of aggregating agents. Long term fertilization significantly redistributed macroaggregates; this could be mainly ascribed to soil organic matter contributing to the formation of 0.5-2 mm classes of aggregates and a decrease in the formation of the >2 mm class of aggregates, especially in the MNPK treatment. Overall, hyphae represented a major aggregating agent in both of the systems tested, while soil organic compounds played significantly different roles in stabilizing aggregates in Anthrosol when the cropping system and the soil management regimes were compared.

  6. Aggregation and Breakup of Colloidal Particle Aggregates in Shear Flow, Studied with Video Microscopy

    NARCIS (Netherlands)

    Tolpekin, V.A.; Duits, Michael H.G.; van den Ende, Henricus T.M.; Mellema, J.

    2004-01-01

    We used video microscopy to study the behavior of aggregating suspensions in shear flow. Suspensions consisted of 920 nm diameter silica spheres, dispersed in a methanol/bromoform solvent, to which poly(ethylene glycol) (M = 35.000 g) was added to effect weak particle aggregation. With our solvent

  7. Some aspects of operational reliability of the JET central interlock and safety system (CISS) in the period March 1984 to December 1986

    International Nuclear Information System (INIS)

    Montfoort, Joop van.

    1987-01-01

    The Central Interlock and Safety System (CISS) provides basic safety functions for the JET plant. It monitors the status of emergency push buttons, access doors and plant equipment and takes corrective shutdown actions in the case that plant conditions are not compatible with safe operation. CISS consists of a hierarchical network of PLCs (programmable logic controllers) paralleling the CODAS architecture. It has been successfully in operation since June 1983 and has intervened many times and halted operation to protect JET from (further) damage or personnel against danger. The note will analyse genuine CISS failures only, and as will be shown, these failures are all due to malfunctioning of PLC hardware. All CISS failures have failed-safe and resulted in the expected shutdown action. Hence CISS failures have never resulted in a dangerous situation but they have restricted operational availability of JET. (author)

  8. Reuse of mining dams waste for the processing of interlocking blocks for paving; Reaproveitamento de residuos de barragens de mineracao para o processamento de blocos intertravados para pavimentacao

    Energy Technology Data Exchange (ETDEWEB)

    Machado, Raissa Ribeiro Lima; Ribeiro, Guilherme Borges; Silva, Sidney Nicodemos da, E-mail: lima.raissa2@gmail.com [Centro Federal de Educacao Tecnologica (DEMAT/CEFET-MG), Belo Horizonte, MG (Brazil). Departamento de Engenharia de Materiais

    2014-07-01

    The environmental impact of mining dam residues can be mitigated by their reuse in the production of interlocking blocks for pavements with a mechanical strength greater than 50 MPa. From the mixture of cement CPV-ARI, sand and gravel, the characterization of the mechanical and physicochemical properties was performed by the following procedures: SEM, FRX, XRD, compression tests and thermal analysis (DSC). These blocks produced from these residues can be considered an economical alternative for the mining depletion cycle in the State of Minas Gerais. This work sought to improve the traces with the replacement the sand of the rivers bed by residues of mining dams that can represent an opportunity for generation of employment and income.

  9. Tetranuclear zinc(II-oxy (benzothiazole-2-thiolate aggregate and copper(I phenylthiolate aggregate

    Directory of Open Access Journals (Sweden)

    Abir Goswami

    2015-12-01

    Full Text Available A tetranuclear zinc-oxy (benzothiazole-2-thiolate aggregate whose structure has a C3-axis passing through ZnO unit relating three other zinc ions and a tetranuclear copper(I phenylthiolate aggregate having each thiphenolate ligand bridging three copper ions are reported. These aggregates were prepared by hydrothermal reactions of 2,2′-dithiobis-(benzothiazole with zinc nitrate or copper(I iodide, respectively. The reaction of zinc nitrate passed through in situ abstraction of a oxy ligand from moisture to form a Zn4O core holding six 2-benzothiazolethiolate ligands, and during the formation of the aggregate, cleavage of S–S bond of 2,2′-dithiobis-(benzothiazole took place. Whereas, an aggregate formed by self-assembling of copper(I phenylthiolate was formed after extensive degradation of 2,2′-dithiobis-(benzothiazole during solvothermal reaction.

  10. SUMO modulation of protein aggregation and degradation

    Directory of Open Access Journals (Sweden)

    Marco Feligioni

    2015-09-01

    Full Text Available Small ubiquitin-like modifier (SUMO conjugation and binding to target proteins regulate a wide variety of cellular pathways. The functional aspects of SUMOylation include changes in protein-protein interactions, intracellular trafficking as well as protein aggregation and degradation. SUMO has also been linked to specialized cellular pathways such as neuronal development and synaptic transmission. In addition, SUMOylation is associated with neurological diseases associated with abnormal protein accumulations. SUMOylation of the amyloid and tau proteins involved in Alzheimer's disease and other tauopathies may contribute to changes in protein solubility and proteolytic processing. Similar events have been reported for α-synuclein aggregates found in Parkinson's disease, polyglutamine disorders such as Huntington's disease as well as protein aggregates found in amyotrophic lateral sclerosis (ALS. This review provides a detailed overview of the impact SUMOylation has on the etiology and pathology of these related neurological diseases.

  11. Principles of Need and the Aggregation Thesis.

    Science.gov (United States)

    Gustavsson, Erik; Juth, Niklas

    2017-09-02

    Principles of need are constantly referred to in health care priority setting. The common denominator for any principle of need is that it will ascribe some kind of special normative weight to people being worse off. However, this common ground does not answer the question how a plausible principle of need should relate to the aggregation of benefits across individuals. Principles of need are sometimes stated as being incompatible with aggregation and sometimes characterized as accepting aggregation in much the same way as utilitarians do. In this paper we argue that if one wants to take principles of need seriously both of these positions have unreasonable implications. We then characterize and defend a principle of need consisting of sufficientarian elements as well as prioritarian which avoids these unreasonable implications.

  12. Multi-Dimensional Aggregation for Temporal Data

    DEFF Research Database (Denmark)

    Böhlen, M. H.; Gamper, J.; Jensen, Christian Søndergaard

    2006-01-01

    Business Intelligence solutions, encompassing technologies such as multi-dimensional data modeling and aggregate query processing, are being applied increasingly to non-traditional data. This paper extends multi-dimensional aggregation to apply to data with associated interval values that capture...... when the data hold. In temporal databases, intervals typically capture the states of reality that the data apply to, or capture when the data are, or were, part of the current database state. This paper proposes a new aggregation operator that addresses several challenges posed by interval data. First......, the intervals to be associated with the result tuples may not be known in advance, but depend on the actual data. Such unknown intervals are accommodated by allowing result groups that are specified only partially. Second, the operator contends with the case where an interval associated with data expresses...

  13. Combined research effort on aggregate road materials

    Science.gov (United States)

    Kuznetsova, Elena; Hoff, Inge; Willy Danielsen, Svein; Wigum, Børge Johannes; Fladvad, Marit; Rieksts, Karlis; Loranger, Benoit; Barbieri, Diego

    2017-04-01

    In European countries, the average aggregate consumption per capita is 5 tons per year (European Aggregates Association 2016), while the corresponding number in Norway is 11 tons (Neeb 2015). Due to the increased demand for sand and gravel for construction purposes, e.g. in road construction, the last decade has seen a significant trend towards the use of crushed rock aggregates. Neeb (2015) reports that half of the Norwegian aggregate production (sand, gravel and crushed rock) is used for road construction, and 33 % of the overall sold tonnage of crushed rock is exported. This resource has been more and more preferred over sand and gravel due to the significant technological development of its process and utilization phase. In Norway, the development and implementation of crushed aggregate technology has been the main approach to solve natural resource scarcity (Danielsen and Kuznetsova 2015). In order to reduce aggregates transportation, it is aimed to use local aggregates and aggregates processed from rock excavations, tunneling, road cuts, etc. One issue focused in this research is the influence from blasting and processing on the final quality of the crushed aggregates, specifically relating to the properties for road construction purposes. It is therefor crucial to plan utilization of available materials for use in different road layers following the same production line. New developments and improved availability of mobile crushing and screening equipment could produce more sustainable and profitable sources of good quality aggregate materials from small volume deposits in proximity to construction sites. One of the biggest challenges today to use these materials is that the pavement design manual sets rigid requirements for pavement layers. Four research projects are being conducted in Norway to improve the use of local materials for road construction. Four aspects are to be covered by the research: a) geological characteristics of the materials, their b

  14. On Aggregating Human Capital Across Heterogeneous Cohorts

    DEFF Research Database (Denmark)

    Growiec, Jakub; Groth, Christian

    Based on a general framework for computing the aggregate human capital stock under heterogeneity across population cohorts, the paper derives aggregate human capital stocks in the whole population and in the labor force, and relates these variables to average years of schooling and average work...... experience. Under the scenarios considered here, the "macro-Mincer" (log-linear) relationship between aggregate human capital and average years of schooling is obtained only in cases which are inconsistent with heterogeneity in years of schooling and based on empirically implausible demographic survival laws....... Our numerical results indicate that the macro-Mincer equation can be a reasonable approximation of the true relationship only if returns to schooling and work experience are roughly constant across countries...

  15. Aggregation kinetics and structure of cryoimmunoglobulins clusters

    CERN Document Server

    De Spirito, M; Bassi, F A; Di Stasio, E; Giardina, B; Arcovito, G

    2002-01-01

    Cryoimmunoglobulins are pathological antibodies characterized by a temperature-dependent reversible insolubility. Rheumatoid factors (RF) are immunoglobulins possessing anti-immunoglobulin activity and usually consist of an IgM antibody that recognizes IgG as antigen. These proteins are present in sera of patients affected by a large variety of different pathologies, such as HCV infection, neoplastic and autoimmune diseases. Aggregation and precipitation of cryoimmunoglobulins, leading to vasculiti, are physical phenomena behind such pathologies. A deep knowledge of the physico-chemical mechanisms regulating such phenomena plays a fundamental role in biological and clinical applications. In this work, a preliminary investigation of the aggregation kinetics and of the final macro- molecular structure of the aggregates is presented. Through static light scattering techniques, the gyration radius R/sub g/ and the fractal dimension D/sub m/ of the growing clusters have been determined. However, while the initial ...

  16. Particle networks through aggregation in polymer nanocomposites

    Science.gov (United States)

    Shofner, Meisha; Kaur, Jasmeet; Lee, Ji Hoon

    2011-03-01

    Structure-property research in polymer nanocomposites has often focused on producing systems that are homogeneously dispersed in order to capitalize on the large amount of specific surface area available from nanoparticles. However, inhomogeneous dispersion is often obtained and in some cases has been deliberately sought to enhance functional properties through the formation of particle networks. In this research, we are seeking to understand how particle aggregation impacts network formation in polymer nanocomposites as a function of native particle shape. Specifically, we are characterizing nanocomposites comprised of calcium phosphate particles with different shapes and a polyhydroxybutyrate matrix. Experimental results concerning the effect of particle aggregation and shape on polymer crystalline structure, thermal transitions and mechanical properties are presented to correlate particle aggregation to network formation and understand structure-property relationships in these materials.

  17. Relationship between macroeconomic aggregates and bank performance

    Directory of Open Access Journals (Sweden)

    Mitrović Ranka

    2016-01-01

    Full Text Available The aim of the paper is relations between some macroeconomic aggregates and performance of banks. This paper show analysis of trends in gross domestic product, exchange rates, interest rates, inflation load, developments in the balance of payments. On the business side, performance is achieved insight into the liquidity, capital adequacy, and the amount of non-performable loans. The aim of the research is to refute or confirm the interconnectedness of movement values of macroeconomic aggregates and bank performance. The analysis confirmed the association of two set variables. The negative value movements of macroeconomic aggregates directly or indirectly have an impact on the quality of performance of the banking sector. Therefore, it is necessary to define an adequate strategy of the economy, would not it safer to carry out the process of adapting to new developments in the market, such as the global financial crisis, the rise in unproductive enterprises, distrust customers etc.

  18. Wind energy aggregation: A coalitional game approach

    KAUST Repository

    Baeyens, E.

    2011-12-01

    In this paper we explore the extent to which a group of N wind power producers can exploit the statistical benefits of aggregation and quantity risk sharing by forming a willing coalition to pool their variable power to jointly offer their aggregate power output as single entity into a forward energy market. We prove that wind power generators will always improve their expected profit when they aggregate their generated power and use tools from coalitional game theory to design fair sharing mechanisms to allocate the payoff among the coalition participants. We show that the corresponding coalitional game is super-additive and has a nonempty core. Hence, there always exists a mechanism for profit-sharing that makes the coalition stable. However, the game is not convex and the celebrated Shapley value may not belong to the core of the game. An allocation mechanism that minimizes the worst-case dissatisfaction is proposed. © 2011 IEEE.

  19. Participation of an Energy Storage Aggregator in Electricity Markets

    OpenAIRE

    Contreras-Ocana, Jesus E.; Ortega-Vazquez, Miguel A.; Zhang, Baosen

    2017-01-01

    An important function of aggregators is to enable the participation of small energy storage units in electricity markets. This paper studies two generally overlooked aspects related to aggregators of energy storage: i) the relationship between the aggregator and its constituent storage units and ii) the aggregator's effect on system welfare. Regarding i), we show that short-term outcomes can be Pareto-inefficient: all players could be better-off. In practice, however, aggregators and storage ...

  20. Recycled aggregates in concrete production: engineering properties and environmental impact

    OpenAIRE

    Seddik Meddah Mohammed

    2017-01-01

    Recycled concrete aggregate is considered as the most abundant and used secondary aggregate in concrete production, other types of solid waste are also being used in concrete for specific purposes and to achieve some desired properties. Recycled aggregates and particularly, recycled concrete aggregate substantially affect the properties and mix design of concrete both at fresh and hardened states since it is known by high porosity due to the adhered layer of old mortar on the aggregate which ...

  1. Customer Aggregation: An Opportunity for Green Power?; TOPICAL

    International Nuclear Information System (INIS)

    Holt, E.; Bird, L.

    2001-01-01

    We undertook research into the experience of aggregation groups to determine whether customer aggregation offers an opportunity to bring green power choices to more customers. The objectives of this report, therefore, are to (1) identify the different types of aggregation that are occurring today, (2) learn whether aggregation offers an opportunity to advance sales of green power, and (3) share these concepts and approaches with potential aggregators and green power advocates

  2. A comparison of thermal zone aggregation methods

    Energy Technology Data Exchange (ETDEWEB)

    Dobbs, Justin R. [Cornell University; Hencey, Brandon M. [Cornell University

    2012-12-10

    The impact of increasing energy prices on building operation budgets has fueled demand for more energy-efficient structures. Existing building energy simulation tools generate an immense amount of data yet comparatively little knowledge. This paper introduces a framework that allows aggregation-based model reduction to operate on geometric building information models. The resulting aggregation sequence provides designers with faster simulations and affords insight into complex multi-scale thermal interactions. A comparison of the trade-off between simulation speed and accuracy for three hierarchical cluster partitioning methods concludes the discussion.

  3. Location Aggregation of Spatial Population CTMC Models

    Directory of Open Access Journals (Sweden)

    Luca Bortolussi

    2016-10-01

    Full Text Available In this paper we focus on spatial Markov population models, describing the stochastic evolution of populations of agents, explicitly modelling their spatial distribution, representing space as a discrete, finite graph. More specifically, we present a heuristic approach to aggregating spatial locations, which is designed to preserve the dynamical behaviour of the model whilst reducing the computational cost of analysis. Our approach combines stochastic approximation ideas (moment closure, linear noise, with computational statistics (spectral clustering to obtain an efficient aggregation, which is experimentally shown to be reasonably accurate on two case studies: an instance of epidemic spreading and a London bike sharing scenario.

  4. Fluorescence turn on by cholate aggregates.

    Science.gov (United States)

    Baldridge, Anthony; Amador, Adrian; Tolbert, Laren M

    2011-04-05

    Bile salts, including sodium cholate (NaCh), are amphiphilic molecules with a concave hydrophilic side and a convex hydrophobic side. By forming aggregates in aqueous solution, these natural surfactants fulfill vital biological roles in the solubilization of cholesterol, lipids, and fat-soluble vitamins and thus are involved in the transport and absorption of important biological molecules. Following our success with the encapsulation of fluorescent protein chromophore (FP) analogs by synthetic hydrophobic and hydrophilic hosts, based upon substitution patterns, we now report the binding and turn on of other analogs by bile salt aggregates, observations which may lead to new tools for studying trafficking in these important systems.

  5. Pre-aggregation for Probability Distributions

    DEFF Research Database (Denmark)

    Timko, Igor; Dyreson, Curtis E.; Pedersen, Torben Bach

    computations of aggregate values. The paper also reports on the experiments with the methods. The work is motivated with a real-world case study, based on our collaboration with a leading Danish vendor of location-based services. No previous work considers the combination of the aspects of uncertain......Motivated by the increasing need to analyze complex uncertain multidimensional data (e.g., in order to optimize and personalize location-based services), this paper proposes novel types of {\\em probabilistic} OLAP queries that operate on aggregate values that are probability distributions...

  6. Fault tolerant aggregation for power system services

    DEFF Research Database (Denmark)

    Kosek, Anna Magdalena; Gehrke, Oliver; Kullmann, Daniel

    2013-01-01

    Exploiting the flexibility in distributed energy resources (DER) is seen as an important contribution to allow high penetrations of renewable generation in electrical power systems. However, the present control infrastructure in power systems is not well suited for the integration of a very large...... number of small units. A common approach is to aggregate a portfolio of such units together and expose them to the power system as a single large virtual unit. In order to realize the vision of a Smart Grid, concepts for flexible, resilient and reliable aggregation infrastructures are required...

  7. PUREX source Aggregate Area management study report

    International Nuclear Information System (INIS)

    1993-03-01

    This report presents the results of an aggregate area management study (AAMS) for the PUREX Plant Aggregate Area in the 200 Areas of the US Department of Energy (DOE)Hanford Site in Washington State. This scoping level study provides the basis for initiating Remedial Investigation/Feasibility Study (RI/FS) activities under the comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) or Resource Conservation and Recovery Act (RCRA) Facility Investigations (RFI) and Corrective Measures Studies (CMS) under RCRA. This report also integrates select RCRA treatment, storage, or disposal (TSD) closure activities with CERCLA and RCRA past-practice investigations

  8. 200 North Aggregate Area source AAMS report

    International Nuclear Information System (INIS)

    1993-06-01

    This report presents the results of an aggregate area management study (AAMS) for the 200 North Aggregate Area in the 200 Areas of the US Department of Energy (DOE) Hanford Site in Washington State. This scoping level study provides the basis for initiating Remedial Investigation/Feasibility Study (RI/FS) activities under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) or Resource Conservation and Recovery Act (RCRA) Facility Investigations (RFI) and Corrective Measures Studies (CMS) under RCRA. This report also integrates select RCRA treatment, storage, or disposal (TSD) closure activities with CERCLA and RCRA past practice investigations

  9. 200 North Aggregate Area source AAMS report

    Energy Technology Data Exchange (ETDEWEB)

    1993-06-01

    This report presents the results of an aggregate area management study (AAMS) for the 200 North Aggregate Area in the 200 Areas of the US Department of Energy (DOE) Hanford Site in Washington State. This scoping level study provides the basis for initiating Remedial Investigation/Feasibility Study (RI/FS) activities under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) or Resource Conservation and Recovery Act (RCRA) Facility Investigations (RFI) and Corrective Measures Studies (CMS) under RCRA. This report also integrates select RCRA treatment, storage, or disposal (TSD) closure activities with CERCLA and RCRA past practice investigations.

  10. Influence of Aggregate Wettability with Different Lithology Aggregates on Concrete Drying Shrinkage

    Directory of Open Access Journals (Sweden)

    Yuanchen Guo

    2015-01-01

    Full Text Available The correlation of the wettability of different lithology aggregates and the drying shrinkage of concrete materials is studied, and some influential factors such as wettability and wetting angle are analyzed. A mercury porosimeter is used to measure the porosities of different lithology aggregates accurately, and the pore size ranges that significantly affect the drying shrinkage of different lithology aggregate concretes are confirmed. The pore distribution curve of the different coarse aggregates is also measured through a statistical method, and the contact angle of different coarse aggregates and concrete is calculated according to the linear fitting relationship. Research shows that concrete strength is determined by aggregate strength. Aggregate wettability is not directly correlated with concrete strength, but wettability significantly affects concrete drying shrinkage. In all types’ pores, the greatest impacts on wettability are capillary pores and gel pores, especially for the pores of the size locating 2.5–50 nm and 50–100 nm two ranges.

  11. DENDRIMER CONJUGATES FOR SELECTIVE OF PROTEIN AGGREGATES

    DEFF Research Database (Denmark)

    2004-01-01

    Dendrimer conjugates are presented, which are formed between a dendrimer and a protein solubilising substance. Such dendrimer conjugates are effective in the treatment of protein aggregate-related diseases (e.g. prion-related diseases). The protein solubilising substance and the dendrimer together...

  12. Aggregation process, application to nuclear multifragmentation

    International Nuclear Information System (INIS)

    Garcia, Jean-Baptiste

    1995-01-01

    It is depicted an aggregation model (applied to nuclear multifragmentation) which I have elaborated and validated. This model contains an aggregation procedure, allowing one to determine the aggregation state of a given system. It takes into account spatial and kinetic nucleonic information, as well as in-medium effects. It is made of several energetic linkage criterions, all based on a single quantity: the energy of a system computed in its center of mass frame. This procedure has been applied to nuclear physics, assuming nucleus as a mix of two Fermi gas, interacting via the Yukawa potential (plus Coulomb in between protons) and obeying to a classical exclusion principle. The general trends of the model match with those of nuclear physics. Moreover, two comparisons between the model and nuclear multifragmentation experiments (ALADIN, then FOPI) exhibit nice agreements. The FOPI one, shows that fragments are bound to be formed at the beginning of the expansion phase (Au + Au at 150 MeV/nuc, for central collisions). This work ends with a study of the main ingredients included in the model. It reveals that in-medium effects, exclusion principle as well as the shape of the potential have a non negligible influence on the studied nuclear aggregation process. (author) [fr

  13. Aggregate Measures of Watershed Health from Reconstructed ...

    Science.gov (United States)

    Risk-based indices such as reliability, resilience, and vulnerability (R-R-V), have the potential to serve as watershed health assessment tools. Recent research has demonstrated the applicability of such indices for water quality (WQ) constituents such as total suspended solids and nutrients on an individual basis. However, the calculations can become tedious when time-series data for several WQ constituents have to be evaluated individually. Also, comparisons between locations with different sets of constituent data can prove difficult. In this study, data reconstruction using relevance vector machine algorithm was combined with dimensionality reduction via variational Bayesian noisy principal component analysis to reconstruct and condense sparse multidimensional WQ data sets into a single time series. The methodology allows incorporation of uncertainty in both the reconstruction and dimensionality-reduction steps. The R-R-V values were calculated using the aggregate time series at multiple locations within two Indiana watersheds. Results showed that uncertainty present in the reconstructed WQ data set propagates to the aggregate time series and subsequently to the aggregate R-R-V values as well. serving as motivating examples. Locations with different WQ constituents and different standards for impairment were successfully combined to provide aggregate measures of R-R-V values. Comparisons with individual constituent R-R-V values showed that v

  14. Determinants of Aggregate Agricultural Productivity among High ...

    African Journals Online (AJOL)

    Results showed that farm sizes, capital input, number of crops planted in a mixture in the farm, labour input, expenditure on planting materials, non farm income, distance to the nearest market, level of education and farming experience are the statistically significant determinants of aggregate agricultural productivity among ...

  15. Multiple wave scattering from fractal aggregates

    Energy Technology Data Exchange (ETDEWEB)

    Korvin, Gabor E-mail: gabor@kfupm.edu.sa; Oleschko, Klavdia

    2004-01-01

    Multiple scattered waves from fractal aggregates create spurious resonances in the high-frequency part of the wave-field's Fourier spectrum. It is shown by a probabilistic convolutional model that for extended fractal media with strong scattering cross-section, multiple scattering can affect the value of the fractal dimension estimated from the wave-field's Fourier power spectrum.

  16. Quasi-Species and Aggregate Dynamics

    DEFF Research Database (Denmark)

    Eriksson, Anders; Görnerup, Olof; Jacobi, Martin Nilsson

    2005-01-01

    At an early stage in pre-biotic evolution, groups of replicating molecules must coordinate their reproduction to form aggregated units of selection. Mechanisms that enable this to occur are currently not well understood. In this paper we introduce a deterministic model of primitive replicating ag...

  17. Characterization of Cross-Linked Lipase Aggregates

    DEFF Research Database (Denmark)

    Prabhavathi Devi, Bethala Lakshmi Anu; Guo, Zheng; Xu, Xuebing

    2009-01-01

    Commercially available microbial lipases from different sources were immobilized as cross-linked enzyme aggregates (CLEAs) using different precipitants and glutaraldehyde as cross-linkers. These CLEAs were assayed based on esterification between lauric acid and n-propanol in solvent-free systems...

  18. Globalization and Aggregate Employment Nexus: A Recent ...

    African Journals Online (AJOL)

    Since Nigeria is monotonically dependent on external trade for survival, globalization measured by the ratio of export plus import to GDP soared for the period. Coincidentally, aggregate employment in the industrial sector also rose, at least from liturgical observation. This paper therefore examined this relationship using ...

  19. Mechanical and thermal properties of prepacked aggregate ...

    Indian Academy of Sciences (India)

    It has been found that POFA significantly reduces the temperature rise in prepacked aggregate concrete and delay the transfer of heat to the concrete body. The compressive and tensile strengths, however, increased with replacement up to20% POFA. The results obtained and the observation made in this study suggest that ...

  20. Aggregating Google Trends: Multivariate Testing and Analysis

    OpenAIRE

    France, Stephen L.; Shi, Yuying

    2017-01-01

    Google Trends is a valuable source of econnomic information. Previous studies have utilized Google Trends data for economic forcasting. We expand this work by providing algorithms to combine and aggregate Trends data and show how time series clustering can be used to analyze competition.

  1. Utilitarian Aggregation of Beliefs and Tastes.

    Science.gov (United States)

    Gilboa, Itzhak; Samet, Dov; Schmeidler, David

    2004-01-01

    Harsanyi's utilitarianism is extended here to Savage's framework. We formulate a Pareto condition that implies that both society's utility function and its probability measure are linear combinations of those of the individuals. An indiscriminate Pareto condition has been shown to contradict linear aggregation of beliefs and tastes. We argue that…

  2. Comparative analysis of aggregate agricultural productivity between ...

    African Journals Online (AJOL)

    The study compared the aggregate agricultural productivity between the Low External Input Technology (LEIT) and High External Input Technology (HEIT) Farms in Imo State of Nigeria. The state is divided into three agricultural zones, out of which two were randomly selected for the study. Using a multistage sampling ...

  3. Colloidal Aggregate Structure under Shear by USANS

    Science.gov (United States)

    Chatterjee, Tirtha; van Dyk, Antony K.; Ginzburg, Valeriy V.; Nakatani, Alan I.

    2015-03-01

    Paints are complex formulations of polymeric binders, inorganic pigments, dispersants, surfactants, colorants, rheology modifiers, and other additives. A commercially successful paint exhibits a desired viscosity profile over a wide shear rate range from 10-5 s-1 for settling to >104 s-1 for rolling, and spray applications. Understanding paint formulation structure is critical as it governs the paint viscosity profile. However, probing paint formulation structure under shear is a challenging task due to the formulation complexity containing structures with different hierarchical length scales and their alterations under the influence of an external flow field. In this work mesoscale structures of paint formulations under shear are investigated using Ultra Small-Angle Neutron Scattering (rheo-USANS). Contrast match conditions were utilized to independently probe the structure of latex binder particle aggregates and the TiO2 pigment particle aggregates. Rheo-USANS data revealed that the aggregates are fractal in nature and their self-similarity dimensions and correlations lengths depend on the chemistry of the binder particles, the type of rheology modifier present and the shear stress imposed upon the formulation. These results can be explained in the framework of diffusion and reaction limited transient aggregates structure evolution under simple shear.

  4. Aggregate Unemployment Decreases Individual Returns to Education

    Science.gov (United States)

    Ammermueller, Andreas; Kuckulenz, Anja; Zwick, Thomas

    2009-01-01

    Aggregate unemployment may affect individual returns to education through qualification-specific responses in participation and wage bargaining. This paper shows that an increase in regional unemployment by 1% decreases returns to education by 0.005 percentage points. This implies that higher skilled employees are better sheltered from labour…

  5. Quasi-Species and Aggregate Dynamics

    DEFF Research Database (Denmark)

    Eriksson, Anders; Görnerup, Olof; Jacobi, Martin Nilsson

    2005-01-01

    aggregates, proto-organisms, that host populations of replicating information carrying molecules. Some of the molecules promote the reproduction of the proto-organism at the cost of their individual replication rate. A situation resembling that of group selection arises. We derive and analytically solve...

  6. Aggregation of log-linear risks

    DEFF Research Database (Denmark)

    Embrechts, Paul; Hashorva, Enkeleijd; Mikosch, Thomas Valentin

    2014-01-01

    In this paper we work in the framework of a k-dimensional vector of log-linear risks. Under weak conditions on the marginal tails and the dependence structure of a vector of positive risks, we derive the asymptotic tail behaviour of the aggregated risk {and present} an application concerning log......-normal risks with {stochastic volatility....

  7. EFFECT OF AGGREGATION ON VIBRIO CHOLERAE INACTIVATION

    Science.gov (United States)

    Extensive research has shown that microorganisms exhibit increased resistance due to clumping, aggregation, particle association, or modification of antecedent growth conditions. During the course of investigating a major water-borne Vibrio cholerae outbreak in Peru, U.S. EPA inv...

  8. Kinetics of fibrilar aggregation of food proteins

    NARCIS (Netherlands)

    Arnaudov, L.N.

    2005-01-01

    In this thesis we study the kinetics of fibrilar aggregation of two model proteins widely used in the food industry -b-lactoglobulin (b-lg) and hen

  9. Stay connected: Electrical conductivity of microbial aggregates.

    Science.gov (United States)

    Li, Cheng; Lesnik, Keaton Larson; Liu, Hong

    2017-11-01

    The discovery of direct extracellular electron transfer offers an alternative to the traditional understanding of diffusional electron exchange via small molecules. The establishment of electronic connections between electron donors and acceptors in microbial communities is critical to electron transfer via electrical currents. These connections are facilitated through conductivity associated with various microbial aggregates. However, examination of conductivity in microbial samples is still in its relative infancy and conceptual models in terms of conductive mechanisms are still being developed and debated. The present review summarizes the fundamental understanding of electrical conductivity in microbial aggregates (e.g. biofilms, granules, consortia, and multicellular filaments) highlighting recent findings and key discoveries. A greater understanding of electrical conductivity in microbial aggregates could facilitate the survey for additional microbial communities that rely on direct extracellular electron transfer for survival, inform rational design towards the aggregates-based production of bioenergy/bioproducts, and inspire the construction of new synthetic conductive polymers. Copyright © 2017 Elsevier Inc. All rights reserved.

  10. School Quality, Educational Attainment and Aggregation Bias

    OpenAIRE

    Fertig, Michael; Wright, Robert E.

    2003-01-01

    Data from 31 countries participating in the Programme for International Student Assessment (PISA) is used to estimate education production functions for reading literacy. The analysis suggests that the probability of finding statistically significant and correctly signed class size effects increases the higher the level of aggregation used to measure class size.

  11. An Aß concatemer with altered aggregation propensities

    DEFF Research Database (Denmark)

    Giehm, L; Dal Degan, F; Fraser, P

    2010-01-01

    We present an analysis of the conformational and aggregative properties of an A beta concatemer (Con-Alz) of interest for vaccine development against Alzheimer's disease. Con-Alz consists of 3 copies of the 43 residues of the A beta peptide separated by the P2 and P30 T-cell epitopes from...

  12. Does it Matter How to Measure Aggregates?

    DEFF Research Database (Denmark)

    Beyer, Andreas; Juselius, Katarina

    Beyer, Doornik and Hendry (2000, 2001) show analytically that three out of four aggregation methods yield problematic results when exchange rate shifts induce relative-price changes between individual countries and found the least problematic method to be the variable weight method of growth rates...

  13. Comparative evaluation of mineral trioxide aggregate and ...

    African Journals Online (AJOL)

    MTA) as an apical barrier material are limited, and no studies have so far examined the clinical performance of BioAggregate as apical barrier material in nonvital immature teeth. Aim: This study was aimed to provide a comparative evaluation of ...

  14. Surfactant effects on soil aggregate tensile strength

    Science.gov (United States)

    Little is known regarding a soil aggregate's tensile strength response to surfactants that may be applied to alleviate soil water repellency. Two laboratory investigations were performed to determine surfactant effects on the tensile strength of 1) Ap horizons of nine wettable, agricultural soils co...

  15. A kinetic equation for irreversible aggregation

    International Nuclear Information System (INIS)

    Zanette, D.H.

    1990-09-01

    We introduce a kinetic equation for describing irreversible aggregation in the ballistic regime, including velocity distributions. The associated evolution for the macroscopic quantities is studied, and the general solution for Maxwell interaction models is obtained in the Fourier representation. (author). 23 refs

  16. A vertically resolved model for phytoplankton aggregation

    Indian Academy of Sciences (India)

    for example presented in this work, due to aggregation of phytoplankton. This variation can be of importance for the orga- nisms living on the ocean floor, because it determines the amount and quality of food that supplies benthic organisms. It also determines how much, and how fast carbon, that has been fixed in the upper ...

  17. Decomposition and aggregation in queueing networks

    NARCIS (Netherlands)

    Huisman, Tijs; Boucherie, Richardus J.; van Dijk, Nico; van Dijk, Nico M.

    2011-01-01

    This chapter considers the decomposition and aggregation of multiclass queueing networks with state-dependent routing. Combining state-dependent generalisations of quasi-reversibility and biased local balance, sufficient conditions are obtained under which the stationary distribution of the network

  18. Assays for alpha-synuclein aggregation

    DEFF Research Database (Denmark)

    Giehm, Lise; Lorenzen, Nikolai; Otzen, Daniel

    2011-01-01

    Over the last few decades, protein aggregation gone from being an irritating side product in the test tube to becoming a subject of great interest. This has been stimulated by the realization that a large and growing number of diseases is associated with the formation and accumulation of proteins...

  19. Single particle detection and characterization of synuclein co-aggregation

    International Nuclear Information System (INIS)

    Giese, Armin; Bader, Benedikt; Bieschke, Jan; Schaffar, Gregor; Odoy, Sabine; Kahle, Philipp J.; Haass, Christian; Kretzschmar, Hans

    2005-01-01

    Protein aggregation is the key event in a number of human diseases such as Alzheimer's and Parkinson's disease. We present a general method to quantify and characterize protein aggregates by dual-colour scanning for intensely fluorescent targets (SIFT). In addition to high sensitivity, this approach offers a unique opportunity to study co-aggregation processes. As the ratio of two fluorescently labelled components can be analysed for each aggregate separately in a homogeneous assay, the molecular composition of aggregates can be studied even in samples containing a mixture of different types of aggregates. Using this method, we could show that wild-type α-synuclein forms co-aggregates with a mutant variant found in familial Parkinson's disease. Moreover, we found a striking increase in aggregate formation at non-equimolar mixing ratios, which may have important therapeutic implications, as lowering the relative amount of aberrant protein may cause an increase of protein aggregation leading to adverse effects

  20. Transportation and utilization of aggregates for road construction

    Science.gov (United States)

    Fladvad, Marit; Wigum, Børge Johannes; Aurstad, Joralf

    2017-04-01

    Road construction relies on non-renewable aggregate resources as the main construction material. Sources for high-quality aggregate resources are scattered, and requirements for aggregate quality can cause long transport distances between quarry and road construction site. In European countries, the average aggregate consumption per capita is 5 tonnes per year (European Aggregates Association, 2016), while the corresponding figure for Norway is 11 tonnes (Neeb, 2015). Half the Norwegian aggregate production (sand, gravel and crushed rock) is used for road construction. In Norway, aggregate resources have been considered abundant. However, stricter requirement for aggregate quality, and increased concern for sustainability and environmental issues have spurred focus on reduction of transport lengths through better utilization of local aggregate materials. In this research project, information about pavement design and aggregate quality requirements were gathered from a questionnaire sent to selected experts from the World Road Organization (PIARC), European Committee for Standardization (CEN), and Nordic Road Association (NVF). The gathered data was compared to identify differences and similarities for aggregate use in the participating countries. Further, the data was compared to known data from Norway regarding: - amount of aggregates required for a road structure - aggregate transport lengths and related costs A total of 18 countries participated in the survey, represented by either road authorities, research institutions, or contractors. There are large variations in practice for aggregate use among the represented countries, and the selection of countries is sufficient to illustrate a variety in pavement designs, aggregate sizes, and quality requirements for road construction. There are considerable differences in both pavement thickness and aggregate sizes used in the studied countries. Total thicknesses for pavement structures varies from 220 mm to 2400 mm

  1. Flow-induced aggregation of colloidal particles in viscoelastic fluids.

    Science.gov (United States)

    Xie, Donglin; Qiao, Greg G; Dunstan, Dave E

    2016-08-01

    The flow-induced aggregation of dilute colloidal polystyrene nanoparticles suspended in Newtonian and viscoelastic solutions is reported. A rheo-optical method has been used to detect real-time aggregation processes via measuring optical absorption or scattering in a quartz Couette cell. The observed absorbance decreases over time are attributed to the flow-induced coagulation. Numerical simulations show that the aggregation processes still follow the Smoluchowski coagulation equation in a revised version. Suspensions in a series of media are studied to evaluate the effect of the media rheological properties on the particle aggregation. The data shows that elasticity reduces the aggregation while the solution viscosity enhances the aggregation processes.

  2. Probabilistic Analysis of Structural Member from Recycled Aggregate Concrete

    Science.gov (United States)

    Broukalová, I.; Šeps, K.

    2017-09-01

    The paper aims at the topic of sustainable building concerning recycling of waste rubble concrete from demolition. Considering demands of maximising recycled aggregate use and minimising of cement consumption, composite from recycled concrete aggregate was proposed. The objective of the presented investigations was to verify feasibility of the recycled aggregate cement based fibre reinforced composite in a structural member. Reliability of wall from recycled aggregate fibre reinforced composite was assessed in a probabilistic analysis of a load-bearing capacity of the wall. The applicability of recycled aggregate fibre reinforced concrete in structural applications was demonstrated. The outcomes refer to issue of high scatter of material parameters of recycled aggregate concretes.

  3. Small file aggregation in a parallel computing system

    Science.gov (United States)

    Faibish, Sorin; Bent, John M.; Tzelnic, Percy; Grider, Gary; Zhang, Jingwang

    2014-09-02

    Techniques are provided for small file aggregation in a parallel computing system. An exemplary method for storing a plurality of files generated by a plurality of processes in a parallel computing system comprises aggregating the plurality of files into a single aggregated file; and generating metadata for the single aggregated file. The metadata comprises an offset and a length of each of the plurality of files in the single aggregated file. The metadata can be used to unpack one or more of the files from the single aggregated file.

  4. Molecular chaperones antagonize proteotoxicity by differentially modulating protein aggregation pathways.

    Science.gov (United States)

    Douglas, Peter M; Summers, Daniel W; Cyr, Douglas M

    2009-01-01

    The self-association of misfolded or damaged proteins into ordered amyloid-like aggregates characterizes numerous neurodegenerative disorders. Insoluble amyloid plaques are diagnostic of many disease states. Yet soluble, oligomeric intermediates in the aggregation pathway appear to represent the toxic culprit. Molecular chaperones regulate the fate of misfolded proteins and thereby influence their aggregation state. Chaperones conventionally antagonize aggregation of misfolded, disease proteins and assist in refolding or degradation pathways. Recent work suggests that chaperones may also suppress neurotoxicity by converting toxic, soluble oligomers into benign aggregates. Chaperones can therefore suppress or promote aggregation of disease proteins to ameliorate the proteotoxic accumulation of soluble, assembly intermediates.

  5. Influence of granitic aggregates from Northeast Brazil on the alkali-aggregate reaction

    Energy Technology Data Exchange (ETDEWEB)

    Gomes Neto, David de Paiva; Santana, Rodrigo Soares de; Barreto, Ledjane Silva, E-mail: pvgomes@uol.com.br [Universidade Federal de Sergipe (UFS), Sao Cristovao, SE (Brazil). Dept. de Ciencias dos Materiais e Engenharia; Conceicao, Herbert; Lisboa, Vinicios Anselmo Carvalho [Universidade Federal de Sergipe (UFS), Sao Cristovao, SE (Brazil). Dept. de Geologia

    2014-08-15

    The alkali-aggregate reaction (AAR) in concrete structures is a problem that has concerned engineers and researchers for decades. This reaction occurs when silicates in the aggregates react with the alkalis, forming an expanded gel that can cause cracks in the concrete and reduce its lifespan. The aim of this study was to characterize three coarse granitic aggregates employed in concrete production in northeastern Brazil, correlating petrographic analysis with the kinetics of silica dissolution and the evolution of expansions in mortar bars, assisted by SEM/EDS, XRD, and EDX. The presence of grains showing recrystallization into individual microcrystalline quartz subgrains was associated with faster dissolution of silica and greater expansion in mortar bars. Aggregates showing substantial deformation, such as stretched grains of quartz with strong undulatory extinction, experienced slower dissolution, with reaction and expansion occurring over longer periods that could not be detected using accelerated tests with mortar bars. (author)

  6. Mechanical properties of concrete containing recycled concrete aggregate (RCA) and ceramic waste as coarse aggregate replacement

    Science.gov (United States)

    Khalid, Faisal Sheikh; Azmi, Nurul Bazilah; Sumandi, Khairul Azwa Syafiq Mohd; Mazenan, Puteri Natasya

    2017-10-01

    Many construction and development activities today consume large amounts of concrete. The amount of construction waste is also increasing because of the demolition process. Much of this waste can be recycled to produce new products and increase the sustainability of construction projects. As recyclable construction wastes, concrete and ceramic can replace the natural aggregate in concrete because of their hard and strong physical properties. This research used 25%, 35%, and 45% recycled concrete aggregate (RCA) and ceramic waste as coarse aggregate in producing concrete. Several tests, such as concrete cube compression and splitting tensile tests, were also performed to determine and compare the mechanical properties of the recycled concrete with those of the normal concrete that contains 100% natural aggregate. The concrete containing 35% RCA and 35% ceramic waste showed the best properties compared with the normal concrete.

  7. Properties of Concrete with Tire Derived Aggregate Partially Replacing Coarse Aggregates

    Directory of Open Access Journals (Sweden)

    Gideon Siringi

    2015-01-01

    Full Text Available Tire derived aggregate (TDA has been proposed as a possible lightweight replacement for mineral aggregate in concrete. The role played by the amount of TDA replacing coarse aggregate as well as different treatment and additives in concrete on its properties is examined. Conventional concrete (without TDA and concrete containing TDA are compared by examining their compressive strength based on ASTM C39, workability based on ASTM C143, splitting tensile strength based on ASTM C496, modulus of rupture (flexural strength based on ASTM C78, and bond stress based on ASTM C234. Results indicate that while replacement of coarse aggregates with TDA results in reduction in strength, it may be mitigated with addition of silica fume to obtain the desired strength. The greatest benefit of using TDA is in the development of a higher ductile product while utilizing recycled TDA.

  8. Properties of Concrete with Tire Derived Aggregate Partially Replacing Coarse Aggregates.

    Science.gov (United States)

    Siringi, Gideon; Abolmaali, Ali; Aswath, Pranesh B

    2015-01-01

    Tire derived aggregate (TDA) has been proposed as a possible lightweight replacement for mineral aggregate in concrete. The role played by the amount of TDA replacing coarse aggregate as well as different treatment and additives in concrete on its properties is examined. Conventional concrete (without TDA) and concrete containing TDA are compared by examining their compressive strength based on ASTM C39, workability based on ASTM C143, splitting tensile strength based on ASTM C496, modulus of rupture (flexural strength) based on ASTM C78, and bond stress based on ASTM C234. Results indicate that while replacement of coarse aggregates with TDA results in reduction in strength, it may be mitigated with addition of silica fume to obtain the desired strength. The greatest benefit of using TDA is in the development of a higher ductile product while utilizing recycled TDA.

  9. Properties of Concrete with Tire Derived Aggregate Partially Replacing Coarse Aggregates

    Science.gov (United States)

    Siringi, Gideon; Abolmaali, Ali; Aswath, Pranesh B.

    2015-01-01

    Tire derived aggregate (TDA) has been proposed as a possible lightweight replacement for mineral aggregate in concrete. The role played by the amount of TDA replacing coarse aggregate as well as different treatment and additives in concrete on its properties is examined. Conventional concrete (without TDA) and concrete containing TDA are compared by examining their compressive strength based on ASTM C39, workability based on ASTM C143, splitting tensile strength based on ASTM C496, modulus of rupture (flexural strength) based on ASTM C78, and bond stress based on ASTM C234. Results indicate that while replacement of coarse aggregates with TDA results in reduction in strength, it may be mitigated with addition of silica fume to obtain the desired strength. The greatest benefit of using TDA is in the development of a higher ductile product while utilizing recycled TDA. PMID:26161440

  10. Phospholipid-nucleoside conjugates: the aggregational characteristics and morphological aspects of selected 1-. beta. -D-arabinofuranosylcytosine 5'-diphosphate-L-1,2-diacylglycerols

    Energy Technology Data Exchange (ETDEWEB)

    Maccoss, M. (Argonne National Lab., IL); Edwards, J.J.; Seed, T.M.; Spragg, S.P.

    1982-01-01

    1-..beta..-D-Arabinofuranosylcytosine 5'-diphosphate-1,2-diacylglycerols have previously been shown to be promising candidates as prodrugs of the clinically useful antileukemic agent 1-..beta..-D-arabinofuranosylcytosine. Because of the amphipathic nature of these liponucleotides and the potential that their morphological state may mediate their biological activity, it was necessary to undertake detailed studies of their aggregational and morphological characteristics. When samples of 1-..beta..-D-arabinofuranosylcytosine 5'-diphosphate-L-1,2-diacylglycerols (containing either dimyristoyl, dipalmitoyl or distearoyl fatty acid side chains) were prepared in buffered saline solutions using sonication methods, the morphological nature of the resulting aggregate was shown to be related to temperature and the length of the side chain. When sonicated at low temperatures all the above-mentioned derivatives gave turbid solutions containing large bilayer sheets. As the temperature was raised, a transition temperature was reached at which a stable three-dimensional cross-linked network of small interlocking bilayer stacks was formed. This turbidity transition temperature was directly related to the chain length of the fatty acid side chain. Sonication at temperatures close to this turbidity transition temperature produced small disc-shaped micellar structures. These micelles were shown to exist in another aggregational equilibrium consisting of a stacking-destacking process, the position within this equilibrium being dependent upon the concentration. In contrast, a sample of 1-..beta..-D-arabinofuranosylcytosine 5'-diphosphate-L-1,2-dioleoylglycerol (which contains an unsaturated carbon-carbon bond in each of the fatty acid side chains) was shown to give a multilamellar liposome structure when sonicated in buffered saline at temperatures above its turbidity transition temperature.

  11. Study of Bond Characteristics of Reinforced Waste Glass Aggregate Concrete

    Science.gov (United States)

    Rajagopalan, P.; Balaji, V.; Unnikrishnan, N.; Jainul Haq, T.; Bhuvaneshwari, P.

    2017-07-01

    The conformity of properties of waste glass aggregate with conventional aggregate was found out. Nine cubes (150mm x 150mm x 150mm) were cast out of which three were used for control concrete, three were fully replaced with waste glass as coarse aggregate, three were partially replaced(50%) with waste glass as fine aggregate. Six cylinders (150mm x 300mm) were cast out of which two for control concrete, two cylinders with coarse aggregate fully replaced with waste glass aggregate(WGA) and remaining two cylinders with partially replaced (50%) fine aggregate with waste glass aggregate. Cured specimens were subjected to compression and split-tensile test to ascertain the characteristic compressive strength and split tensile strength. Since the surface of the coarse aggregate plays a significant role in bonding of the rebar in reinforced concrete, pull-out test on both control and Waste Glass Aggregate (WGA) cube specimens (150mm x 150mm with 20mm diameter steel rods) were conducted. Scanning Electron Microscopy (SEM) analysis has been done for better understanding of bonding properties in waste glass fine aggregate(WGFA) and waste glass coarse aggregate(WGCA) concrete. Comparison of the results with that of control specimens showed that waste glass could be effectively used as aggregates in reinforced concrete construction.

  12. Effect of the Aggregate Size on Strength Properties of Recycled Aggregate Concrete

    Directory of Open Access Journals (Sweden)

    Ma Kang

    2018-01-01

    Full Text Available The study on preparation technology of recycled concrete with economical and technical feasibility has gained more serious attention in each country due to its involvement and effect on the environment protection and the sustainable development of human society. In this study, we conducted a control variable test to investigate and assess the influence of the aggregate size on the strength characteristics of concrete with different diameters of recycled aggregates. Concrete with recycled aggregates of 5∼15 mm (A, 15∼20 mm (B, 20∼30 mm (C, and their combinations were subjected to a series of unconfined pressure tests after curing for 28 days. Based on the results obtained from the tests, an effort was made to study the relationship between the mechanical characteristics of recycled aggregate concrete and aggregate particle size. Also, a regression model of recycled concrete was proposed to predict the elasticity modulus and to adjust the design of mixture proportion. It is believed that these experiment results would contribute to adjust the remediation mixture for recycling plants by considering the influence of recycled aggregate size.

  13. Impact of aggregate gradation on properties of portland cement concrete.

    Science.gov (United States)

    2013-10-01

    Increasingly, aggregates in South Carolina are failing to meet the standard requirements for gradation for use in portland cement concrete. The effect of such failed aggregate gradations on concrete properties and the consequent effect on short- and ...

  14. Cameras instead of sieves for aggregate characterization : research spotlight

    Science.gov (United States)

    2012-01-01

    Michigan researchers explored the use of cameras and software that may eventually replace the use of screen sieves in sizing and assessing crushed aggregate for pavement construction. This research explored approaches to imaging aggregate as a way to...

  15. Pore structure of natural and regenerated soil aggregates

    DEFF Research Database (Denmark)

    Naveed, Muhammad; Arthur, Emmanuel; de Jonge, Lis Wollesen

    2014-01-01

    Quantitative characterization of aggregate pore structure can reveal the evolution of aggregates under different land use and management practices and their effects on soil processes and functions. Advances in X-ray Computed Tomography (CT) provide powerful means to conduct such characterization....... This study examined aggregate pore structure of three differently managed same textured Danish soils (mixed forage cropping, MFC; mixed cash cropping, MCC; cereal cash cropping, CCC) for (i) natural aggregates, and (ii) aggregates regenerated after 20 months of incubation. In total, 27 aggregates (8-16 mm......) were sampled from nine different treatments; 3 natural soils and 3 repacked lysimeters without and 3 with organic matter (ground rape) amendment. Three dimensional X-ray CT images, tensile strength, and organic carbon were obtained for each aggregate. Aggregate-associated organic carbon differed...

  16. Evaluation of recycled concrete as aggregate in new concrete pavements.

    Science.gov (United States)

    2014-04-01

    This study evaluated the use of recycled concrete as coarse aggregate in new concrete pavements. : Recycled concrete aggregate (RCA) produced from demolished pavements in three geographically dispersed locations in Washington state were used to perfo...

  17. Indirect determination of particle shape of fine aggregate.

    Science.gov (United States)

    1973-01-01

    Three methods developed by various agencies for measuring indirectly the particle shapes of fine aggregates were used along with a visual classification procedure to study aggregates from eight commercial sources along with a reference sand. The meth...

  18. The framework for simulation of dynamics of mechanical aggregates

    OpenAIRE

    Ivankov, Petr R.; Ivankov, Nikolay P.

    2007-01-01

    A framework for simulation of dynamics of mechanical aggregates has been developed. This framework enables us to build model of aggregate from models of its parts. Framework is a part of universal framework for science and engineering.

  19. Important Features of Sustainable Aggregate Resource Management

    Directory of Open Access Journals (Sweden)

    Slavko V. Šolar

    2004-06-01

    Full Text Available Every society, whether developed, developing or in a phase of renewal following governmental change, requires stable, adequate and secure supplies of natural resources. In the latter case, there could be significant need for construction materials for rebuilding infrastructure, industrial capacity, and housing. It is essential that these large-volume materials be provided in a rational manner that maximizes their societal contribution and minimizes environmental impacts. We describe an approach to resource management based on the principles of sustainable development. Sustainable Aggregate Resource Management offers a way of addressing the conflicting needs and interests of environmental, economic, and social systems. Sustainability is an ethics based concept that utilizes science and democratic processes to reach acceptable agreements and tradeoffs among interests, while acknowledging the fundamental importance of the environment and social goods. We discuss the features of sustainable aggregate resource management.

  20. Aggregation Processes with Catalysis-Driven Decomposition

    International Nuclear Information System (INIS)

    Xiang Rong; Zhuang Youyi; Ke Jianhong; Lin Zhenquan

    2009-01-01

    We propose a three-species aggregation model with catalysis-driven decomposition. Based on the mean-field rate equations, we investigate the evolution behavior of the system with the size-dependent catalysis-driven decomposition rate J(i; j; k) = Jijk v and the constant aggregation rates. The results show that the cluster size distribution of the species without decomposition can always obey the conventional scaling law in the case of 0 ≤ v ≤ 1, while the kinetic evolution of the decomposed species depends crucially on the index v. Moreover, the total size of the species without decomposition can keep a nonzero value at large times, while the total size of the decomposed species decreases exponentially with time and vanishes finally. (general)

  1. Production of prone-to-aggregate proteins.

    Science.gov (United States)

    Lebendiker, Mario; Danieli, Tsafi

    2014-01-21

    Expression of recombinant proteins in Escherichia coli (E. coli) remains the most popular and cost-effective method for producing proteins in basic research and for pharmaceutical applications. Despite accumulating experience and methodologies developed over the years, production of recombinant proteins prone to aggregate in E. coli-based systems poses a major challenge in most research applications. The challenge of manufacturing these proteins for pharmaceutical applications is even greater. This review will discuss effective methods to reduce and even prevent the formation of aggregates in the course of recombinant protein production. We will focus on important steps along the production path, which include cloning, expression, purification, concentration, and storage. Copyright © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

  2. Modeling decisions information fusion and aggregation operators

    CERN Document Server

    Torra, Vicenc

    2007-01-01

    Information fusion techniques and aggregation operators produce the most comprehensive, specific datum about an entity using data supplied from different sources, thus enabling us to reduce noise, increase accuracy, summarize and extract information, and make decisions. These techniques are applied in fields such as economics, biology and education, while in computer science they are particularly used in fields such as knowledge-based systems, robotics, and data mining. This book covers the underlying science and application issues related to aggregation operators, focusing on tools used in practical applications that involve numerical information. Starting with detailed introductions to information fusion and integration, measurement and probability theory, fuzzy sets, and functional equations, the authors then cover the following topics in detail: synthesis of judgements, fuzzy measures, weighted means and fuzzy integrals, indices and evaluation methods, model selection, and parameter extraction. The method...

  3. Aggregated Control of Domestic Heat Pumps

    DEFF Research Database (Denmark)

    Nielsen, Kirsten M.; Andersen, Palle; Pedersen, Tom S.

    2013-01-01

    A challenge in Denmark in the near future is to balance the electrical grid due to a large increase in the renewable energy production mainly from wind turbines. In this work an aggregated control system using heat pumps in single family houses to help balancing the grid is investigated. The cont......A challenge in Denmark in the near future is to balance the electrical grid due to a large increase in the renewable energy production mainly from wind turbines. In this work an aggregated control system using heat pumps in single family houses to help balancing the grid is investigated....... The control system is able to adjust the consumptions of the heat pump without affecting the comfort in the houses and uses this ability to shift the total consumption to hours with high wind energy production....

  4. Mapuche herbal medicine inhibits blood platelet aggregation.

    Science.gov (United States)

    Falkenberg, Susan Skanderup; Tarnow, Inge; Guzman, Alfonso; Mølgaard, Per; Simonsen, Henrik Toft

    2012-01-01

    12 plant species traditionally used by the Mapuche people in Chile to treat wounds and inflammations have been evaluated for their direct blood platelet inhibition. Seven of the 12 tested plant species showed platelet inhibitory effect in sheep blood, and four of these were also able to inhibit the ADP- (5.0 μM) and collagen- (2.0 μg/mL) induced aggregations in human blood. These four species in respective extracts (in brackets) were Blechnum chilense (MeOH), Luma apiculata (H(2)O), Amomyrtus luma (DCM : MeOH 1 : 1) and Cestrum parqui (DCM : MeOH 1 : 1). The platelet aggregating inhibitory effects of A. luma (DCM : MeOH 1 : 1), and L. apiculata (H(2)O) were substantial and confirmed by inhibition of platelet surface activation markers.

  5. Important features of Sustainable Aggregate Resource Management

    Science.gov (United States)

    Solar, Slavko V.; Shields, Deborah J.; Langer, William H.

    2004-01-01

    Every society, whether developed, developing or in a phase of renewal following governmental change, requires stable, adequate and secure supplies of natural resources. In the latter case, there could be significant need for construction materials for rebuilding infrastructure, industrial capacity, and housing. It is essential that these large-volume materials be provided in a rational manner that maximizes their societal contribution and minimizes environmental impacts. We describe an approach to resource management based on the principles of sustainable developed. Sustainable Aggregate Resource Management offers a way of addressing the conflicting needs and interests of environmental, economic, and social systems. Sustainability is an ethics based concept that utilizes science and democratic processes to reach acceptable agreements and tradeoffs among interests, while acknowledging the fundamental importance of the environment and social goods. We discuss the features of sustainable aggregate resource management.

  6. Mechanochemical symmetry breaking in Hydra aggregates.

    Science.gov (United States)

    Mercker, Moritz; Köthe, Alexandra; Marciniak-Czochra, Anna

    2015-05-05

    Tissue morphogenesis comprises the self-organized creation of various patterns and shapes. Although detailed underlying mechanisms are still elusive in many cases, an increasing amount of experimental data suggests that chemical morphogen and mechanical processes are strongly coupled. Here, we develop and test a minimal model of the axis-defining step (i.e., symmetry breaking) in aggregates of the Hydra polyp. Based on previous findings, we combine osmotically driven shape oscillations with tissue mechanics and morphogen dynamics. We show that the model incorporating a simple feedback loop between morphogen patterning and tissue stretch reproduces a wide range of experimental data. Finally, we compare different hypothetical morphogen patterning mechanisms (Turing, tissue-curvature, and self-organized criticality). Our results suggest the experimental investigation of bigger (i.e., multiple head) aggregates as a key step for a deeper understanding of mechanochemical symmetry breaking in Hydra. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  7. Aggregation-induced emission of siloles

    Science.gov (United States)

    He, Bairong

    2015-01-01

    Aggregation-induced emission (AIE) is a unique and significant photophysical phenomenon that differs greatly from the commonly acknowledged aggregation-caused emission quenching observed for many π-conjugated planar chromophores. The mechanistic decipherment of the AIE phenomenon is of high importance for the advance of new AIE systems and exploitation of their potential applications. Propeller-like 2,3,4,5-tetraphenylsiloles are archetypal AIE-active luminogens, and have been adopted as a core part in the design of numerous luminescent materials with diverse functionalities. In this review article, we elucidate the impacts of substituents on the AIE activity and shed light on the structure–property relationship of siloles, with the aim of promoting the judicious design of AIE-active functional materials in the future. Recent representative advances of new silole-based functional materials and their potential applications are reviewed as well. PMID:28717442

  8. Evaluating aid effectiveness in the aggregate

    DEFF Research Database (Denmark)

    Dalgaard, Carl-Johan Lars; Hansen, Henrik

    The purpose of the present evaluation study is to discuss influential empirical studies that attempt to estimate the impact of foreign aid on economic growth. The study draws on a previous evaluation study, which introduces the general econometric methodology involved in making assessments about...... the aggregate impact of aid (Dalgaard and Hansen, 2009). With point of departure in this study the present report gives a critical assessment of the empirical literature on the topic....

  9. Material properties of frc with recycled aggregate

    Czech Academy of Sciences Publication Activity Database

    Trčková, Jiřina; Procházka, P.

    2011-01-01

    Roč. 8, č. 2 (2011), s. 105-113 ISSN 1214-9705 R&D Projects: GA ČR GA103/08/1197 Institutional research plan: CEZ:AV0Z30460519 Keywords : recycled aggregate * concrete composite * pullout test Subject RIV: JM - Building Engineering Impact factor: 0.530, year: 2011 http://www.irsm.cas.cz/abstracts/AGG/02_11/1_Trckova.pdf

  10. Bulgariana: A Bulgarian Aggregator to Europeana

    OpenAIRE

    Damova, Mariana

    2012-01-01

    Europeana is the European virtual museum which was established in 2008. Its ambition is to create a common space allowing to access the cultural heritage of Europe from a single portal, by creating a network in all European countries. To make the initiative technically possible, Europeana has built a technological infrastructure to aggregate metadata from the different Europeana countries and memory institutions, while keeping the original digitized content on their sites. T...

  11. An Aggregated Public Transit Accessibility Measure

    OpenAIRE

    Al Mamun, Md. Sha; Lownes, Nicholas E.

    2010-01-01

    Measuring the ease of access to the transit services is important in evaluating existing services, predicting travel demands, allocating transportation investments and making decisions on land use development. A new aggregated approach to assessing the accessibility of public transport is described to assist transit professionals in the planning and decision making process. It involves the use of readily available methods and represents a more holistic measure of transit accessibili-ty integr...

  12. Comparative evaluation of mineral trioxide aggregate and ...

    African Journals Online (AJOL)

    All treatment procedures were performed by the same .... teeth included in this study were evaluated for the 24‑month. Table 2: Demographic and baseline characteristics for each group. MTA (n=13). BioAggregate (n=13). Age (years). 8.69±0.41. 8.85±0.45. Sex .... any dental stem cells that might remain in the disinfected.

  13. Social Networks: Rational Learning and Information Aggregation

    Science.gov (United States)

    2009-09-01

    information spreads in social networks and whether the information is efficiently aggregated in large societies. The models developed in this thesis allow us...network). We characterize equilibria for arbitrary stochastic and deterministic social networks and characterize the conditions under which there will be...beliefs there will be asymptotic learning in almost all reasonable social networks . Furthermore we provide bounds on the speed of learning for some

  14. Bacterial Association with Particles: Aggregation to Dissolution

    Digital Repository Service at National Institute of Oceanography (India)

    DeSouza, M.J.B.D.

    an important role in the trophic dynamics of an ecosystem (Fig. 1) Bacterial role in aggregation formation and dissolution In aquatic systems particles are important components in the turnover, decomposition and sinking flux of both organic and inorganic... (Nicholas and Walling, 1998). Although bacteria are responsible for assimilating most of the DOC in aquatic ecosystem, yet the fluxes of DOC through bacteria include a wide variety of compounds derived from unknown sources and composition (Azam et al., 1993...

  15. Spatial and Temporal Aggregation in Racial Profiling

    OpenAIRE

    Dragan Ilić

    2013-01-01

    In the last decade, models of rational choice have chimed into the discussion on racial profiling, the use of race in stop and search decisions of the police. The models describe the behavior of motorists and the police and provide empirical tests to assess the question whether the police exhibit racial animus. However, existing studies have neglected the effect of spatial and temporal aggregation of the data on the application of the tests. Using data from the Florida Highway Patrol, this pa...

  16. Light Induced Aggregation of Specific Single Walled Carbon Nanotubes

    OpenAIRE

    Gopannagari, Madhusudana; Chaturvedi, Harsh

    2015-01-01

    We report optically induced aggregation and consequent separation of specific diameter of pristine single walled carbon nanotubes (SWNT) from stable solution. Well dispersed solution of pristine SWNTs, without any surfactant or functionalization, show rapid aggregation by uniform exposure to UV, visible and NIR illumination. Optically induced aggregation linearly increases with consequent increase in the intensity of light. Aggregated SWNTs were separated from the dispersed supernatant and ch...

  17. Kinetics of Thermal Denaturation and Aggregation of Bovine Serum Albumin.

    Directory of Open Access Journals (Sweden)

    Vera A Borzova

    Full Text Available Thermal aggregation of bovine serum albumin (BSA has been studied using dynamic light scattering, asymmetric flow field-flow fractionation and analytical ultracentrifugation. The studies were carried out at fixed temperatures (60°C, 65°C, 70°C and 80°C in 0.1 M phosphate buffer, pH 7.0, at BSA concentration of 1 mg/ml. Thermal denaturation of the protein was studied by differential scanning calorimetry. Analysis of the experimental data shows that at 65°C the stage of protein unfolding and individual stages of protein aggregation are markedly separated in time. This circumstance allowed us to propose the following mechanism of thermal aggregation of BSA. Protein unfolding results in the formation of two forms of the non-native protein with different propensity to aggregation. One of the forms (highly reactive unfolded form, Uhr is characterized by a high rate of aggregation. Aggregation of Uhr leads to the formation of primary aggregates with the hydrodynamic radius (Rh,1 of 10.3 nm. The second form (low reactive unfolded form, Ulr participates in the aggregation process by its attachment to the primary aggregates produced by the Uhr form and possesses ability for self-aggregation with formation of stable small-sized aggregates (Ast. At complete exhaustion of Ulr, secondary aggregates with the hydrodynamic radius (Rh,2 of 12.8 nm are formed. At 60°C the rates of unfolding and aggregation are commensurate, at 70°C the rates of formation of the primary and secondary aggregates are commensurate, at 80°C the registration of the initial stages of aggregation is complicated by formation of large-sized aggregates.

  18. Concrete manufacture with un-graded recycled aggregates

    OpenAIRE

    Richardson, Alan; Coventry, Kathryn; Graham, Sue

    2009-01-01

    Purpose – The purpose of this paper is to investigate whether concrete that includes un-graded recycled aggregates can be manufactured to a comparable strength to concrete manufactured from virgin aggregates. \\ud \\ud Design/methodology/approach – A paired comparison test was used to evaluate the difference between concrete made with virgin aggregates (plain control) and concrete including recycled waste. Un-graded construction demolition waste and un-graded ground glass were used as aggregate...

  19. Understanding sexual harassment using aggregate construct models.

    Science.gov (United States)

    Nye, Christopher D; Brummel, Bradley J; Drasgow, Fritz

    2014-11-01

    Sexual harassment has received a substantial amount of empirical attention over the past few decades, and this research has consistently shown that experiencing these behaviors has a detrimental effect on employees' well-being, job attitudes, and behaviors at work. However, these findings, and the conclusions that are drawn from them, make the implicit assumption that the empirical models used to examine sexual harassment are properly specified. This article presents evidence that properly specified aggregate construct models are more consistent with theoretical structures and definitions of sexual harassment and can result in different conclusions about the nomological network of harassment. Results from 3 large samples, 2 military and 1 from a civilian population, are used to illustrate the differences between aggregate construct and reflective indicator models of sexual harassment. These analyses suggested that the factor structure and the nomological network of sexual harassment differ when modeling harassment as an aggregate construct. The implications of these results for the continued study of sexual harassment are discussed. (PsycINFO Database Record (c) 2014 APA, all rights reserved).

  20. Role of Prion Protein Aggregation in Neurotoxicity

    Directory of Open Access Journals (Sweden)

    Tullio Florio

    2012-07-01

    Full Text Available In several neurodegenerative diseases, such as Parkinson, Alzheimer’s, Huntington, and prion diseases, the deposition of aggregated misfolded proteins is believed to be responsible for the neurotoxicity that characterizes these diseases. Prion protein (PrP, the protein responsible of prion diseases, has been deeply studied for the peculiar feature of its misfolded oligomers that are able to propagate within affected brains, inducing the conversion of the natively folded PrP into the pathological conformation. In this review, we summarize the available experimental evidence concerning the relationship between aggregation status of misfolded PrP and neuronal death in the course of prion diseases. In particular, we describe the main findings resulting from the use of different synthetic (mainly PrP106-126 and recombinant PrP-derived peptides, as far as mechanisms of aggregation and amyloid formation, and how these different spatial conformations can affect neuronal death. In particular, most data support the involvement of non-fibrillar oligomers rather than actual amyloid fibers as the determinant of neuronal death.

  1. Disaggregases, molecular chaperones that resolubilize protein aggregates

    Directory of Open Access Journals (Sweden)

    David Z. Mokry

    2015-08-01

    Full Text Available The process of folding is a seminal event in the life of a protein, as it is essential for proper protein function and therefore cell physiology. Inappropriate folding, or misfolding, can not only lead to loss of function, but also to the formation of protein aggregates, an insoluble association of polypeptides that harm cell physiology, either by themselves or in the process of formation. Several biological processes have evolved to prevent and eliminate the existence of non-functional and amyloidogenic aggregates, as they are associated with several human pathologies. Molecular chaperones and heat shock proteins are specialized in controlling the quality of the proteins in the cell, specifically by aiding proper folding, and dissolution and clearance of already formed protein aggregates. The latter is a function of disaggregases, mainly represented by the ClpB/Hsp104 subfamily of molecular chaperones, that are ubiquitous in all organisms but, surprisingly, have no orthologs in the cytosol of metazoan cells. This review aims to describe the characteristics of disaggregases and to discuss the function of yeast Hsp104, a disaggregase that is also involved in prion propagation and inheritance.

  2. Characterising risk - aggregated metrics: radiation and noise

    International Nuclear Information System (INIS)

    Passchier, W.

    1998-01-01

    The characterisation of risk is an important phase in the risk assessment - risk management process. From the multitude of risk attributes a few have to be selected to obtain a risk characteristic or profile that is useful for risk management decisions and implementation of protective measures. One way to reduce the number of attributes is aggregation. In the field of radiation protection such an aggregated metric is firmly established: effective dose. For protection against environmental noise the Health Council of the Netherlands recently proposed a set of aggregated metrics for noise annoyance and sleep disturbance. The presentation will discuss similarities and differences between these two metrics and practical limitations. The effective dose has proven its usefulness in designing radiation protection measures, which are related to the level of risk associated with the radiation practice in question, given that implicit judgements on radiation induced health effects are accepted. However, as the metric does not take into account the nature of radiation practice, it is less useful in policy discussions on the benefits and harm of radiation practices. With respect to the noise exposure metric, only one effect is targeted (annoyance), and the differences between sources are explicitly taken into account. This should make the metric useful in policy discussions with respect to physical planning and siting problems. The metric proposed has only significance on a population level, and can not be used as a predictor for individual risk. (author)

  3. Energy Efficient Payload Aggregation in WSNs

    Directory of Open Access Journals (Sweden)

    Ákos MILÁNKOVICH

    2015-06-01

    Full Text Available Creating wireless sensor networks requires a different approach than traditional communication networks because energy efficiency plays a key role in sensor networks, which consist of devices without external power. The amount of energy used determines the lifetime of these devices. In most cases data packets are less sensitive to delay, thus can be aggregated, making it possible to gather more useful information reducing the energy required to transmit information. This article discusses the energy efficiency of different Forward Error Correction algorithms and presents a method to calculate the optimal amount of aggregation of the data packets in terms of power consumption, while taking into account the Bit Error Rate characteristics of the wireless channel. The contribution of this paper is a general method to improve the energy efficiency of wireless sensor networks by using the optimal amount of aggregation in case of different Forward Error Correction codes and channel characteristics. The presented results can be applied to any packet-based wireless protocol.

  4. Creep and shrinkage behaviour of concrete with mixed recycled aggregates

    NARCIS (Netherlands)

    Hordijk, D.A.; Uijl, J. den

    1999-01-01

    For environmental reasons the interest in possibilities to use recycled aggregates in concrete is strongly increasing. World-wide, most attention with respect to recycled aggregates is paid to the quality of the aggregates. Still only limited information is available for the mechanica! properties of

  5. Environmental suitability of recycled concrete aggregate in highways : [research summary].

    Science.gov (United States)

    2015-01-01

    Natural highway aggregate is a finite resource that with continued use in construction : activities but some good quality aggregates used in existing concrete structures may be : re-used to replace with the natural aggregate. Due to the repair or rep...

  6. 5 CFR 581.401 - Aggregate disposable earnings.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Aggregate disposable earnings. 581.401 Section 581.401 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS... § 581.401 Aggregate disposable earnings. The “aggregate disposable earnings”, when used in reference to...

  7. Retiring the Short-Run Aggregate Supply Curve

    Science.gov (United States)

    Elwood, S. Kirk

    2010-01-01

    The author argues that the aggregate demand/aggregate supply (AD/AS) model is significantly improved--although certainly not perfected--by trimming it of the short-run aggregate supply (SRAS) curve. Problems with the SRAS curve are shown first for the AD/AS model that casts the AD curve as identifying the equilibrium level of output associated…

  8. 40 CFR 63.1408 - Aggregate batch vent stream provisions.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 11 2010-07-01 2010-07-01 true Aggregate batch vent stream provisions... § 63.1408 Aggregate batch vent stream provisions. (a) Emission standards. Owners or operators of aggregate batch vent streams at a new or existing affected source shall comply with either paragraph (a)(1...

  9. Cigarette smoking increases white blood cell aggregation in whole blood.

    OpenAIRE

    Bridges, A B; Hill, A; Belch, J J

    1993-01-01

    We studied the effect of chronic cigarette smoking on white blood cell aggregation, increased aggregation predisposes to microvascular occlusion and damage. Current smokers had significantly increased white blood cell aggregation when compared with non smokers. The presence of chronically activated white blood cells in current smokers may be relevant in the pathogenesis of ischaemic vascular disease.

  10. comparative cost and strength analysis of cement and aggregate

    African Journals Online (AJOL)

    2012-07-02

    Jul 2, 2012 ... 30% when palm kernel shell and quarry dust are used as partial replacement for aggregate. This study suggests that; the cost of construction and concrete production can be reduced if cement and aggregate replacement materials are used. Keywords: cement replacement material, aggregate replacement ...

  11. Vocal Fold Mucus Aggregation in Persons with Voice Disorders

    Science.gov (United States)

    Bonilha, Heather Shaw; White, Lisa; Kuckhahn, Kelsey; Gerlach, Terri Treman; Deliyski, Dimitar D.

    2012-01-01

    Mucus aggregation on the vocal folds is a common finding from laryngeal endoscopy. Patients with voice disorders report the presence of mucus aggregation. Patients also report that mucus aggregation causes them to clear their throat, a behavior believed to be harmful to vocal fold mucosa. Even though clinicians and patients report and discuss…

  12. Performance of Uplink Carrier Aggregation in LTE-Advanced Systems

    DEFF Research Database (Denmark)

    Wang, Hua; Rosa, Claudio; Pedersen, Klaus

    2010-01-01

    Carrier aggregation (CA) has been proposed to aggregate two or more component carriers (CCs) to support a much wider transmission bandwidth for LTE-Advanced systems. With carrier aggregation, it is possible to schedule a user equipment (UE) on multiple component carriers simultaneously. In this p...

  13. Efficient external memory structures for range-aggregate queries

    DEFF Research Database (Denmark)

    Agarwal, P.K.; Yang, J.; Arge, L.

    2013-01-01

    We present external memory data structures for efficiently answering range-aggregate queries. The range-aggregate problem is defined as follows: Given a set of weighted points in Rd, compute the aggregate of the weights of the points that lie inside a d-dimensional orthogonal query rectangle. The...

  14. Evaluation of Colemanite Waste as Aggregate Hot Mix Asphalt Concrete

    Directory of Open Access Journals (Sweden)

    Nihat MOROVA

    2015-09-01

    Full Text Available In this study usability of waste colemanite which is obtained after cutting block colemanite for giving proper shape to blocks as an aggregate in hot mix asphalt. For this aim asphalt concrete samples were prepared with four different aggregate groups and optimum bitumen content was determined. First of all only limestone was used as an aggregate. After that, only colemanite aggregate was used with same aggregate gradation. Then, the next step of the study, Marshall samples were produced by changing coarse and fine aggregate gradation as limestone and colemanite and Marshall test were conducted. When evaluated the results samples which produced with only limestone aggregate gave the maximum Marshall Stability value. When handled other mixture groups (Only colemanite, colemanite as coarse aggregate-limestone as fine aggregate, colemanite as fine aggregate-limestone as coarse aggregate all groups were verified specification limits. As a result, especially in areas where there is widespread colemanite waste, if transportation costs did not exceed the cost of limestone, colemanite stone waste could be used instead of limestone in asphalt concrete mixtures as fine aggregate

  15. Aggregate breakdown mechanisms as affected by soil texture and ...

    African Journals Online (AJOL)

    Soil aggregates breakdown mechanisms depend on soil properties such as texture, clay mineralogy and organic matter content. Little is known about the effect of soil properties on aggregate breakdown mechanisms in South African soils. The objective of this study was to establish the relationship between aggregate ...

  16. 21 CFR 1303.13 - Adjustments of aggregate production quotas.

    Science.gov (United States)

    2010-04-01

    ... affecting medical, scientific, research, and industrial needs in the United States and lawful export... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Adjustments of aggregate production quotas. 1303... Aggregate Production and Procurement Quotas § 1303.13 Adjustments of aggregate production quotas. (a) The...

  17. Sustainable normal and high strength recycled aggregate concretes using crushed tested cylinders as coarse aggregates

    Directory of Open Access Journals (Sweden)

    Bilal S. Hamad

    2017-12-01

    Full Text Available The paper reports on a research program that was designed at the American University of Beirut (AUB to investigate the fresh and hardened mechanical properties of a high performance concrete mix produced with partial or full substitution of crushed natural lime-stone aggregates with recycled aggregates from crushed tested cylinders in batching plants. Choosing crushed cylinders as source of recycling would result in reusing portion of the waste products of the concrete production industry. An extensive concrete batching and testing program was conducted to achieve two optimum normal and high strength concrete mixes. The variables were the nominal concrete strength (28 or 60 MPa and the percentage replacement of natural coarse aggregates with recycled aggregates from crushed tested cylinders (0, 20, 40, 60, 80, or 100%. Normal strength tested cylinders were used as source of the recycled aggregates for the normal strength concrete (NSC mix and high strength tested cylinders were used for the high strength concrete (HSC mix. Tests on the trial batches included plastic state slump and hardened state mechanical properties including cylinder compressive strength, cylinder splitting tensile strength, modulus of elasticity, and standard beams flexural strength. The results indicated no significant effect on the slump and around 10% average reduction in the hardened mechanical properties for both investigated levels of concrete compressive strength.

  18. Sand Cement Brick Containing Recycled Concrete Aggregate as Fine-Aggregate Replacement

    Directory of Open Access Journals (Sweden)

    Sheikh Khalid Faisal

    2017-01-01

    Full Text Available Nowadays, the usage amount of the concrete is increasing drastically. The construction industry is a huge consumer of natural consumer. It is also producing the huge wastage products. The usage of concrete has been charged to be not environmentally friendly due to depletion of reserve natural resources, high energy consumption and disposal issues. The conservation of natural resources and reduction of disposal site by reuse and recycling waste material was interest possibilites. The aim of this study is to determine the physical and mechanical properties of sand cement brick containing recycled concrete aggregate and to determine the optimum mix ratio containing recycled concrete aggregate. An experiment done by comparing the result of control specimen using 100% natural sand with recycled concrete aggregate replacement specimen by weight for 55%, 65%, and 75%. The sample was tested under density, compressive strength, flexural strength and water absorption to study the effect of using recycled concrete aggregate on the physical and mechanical properties of bricks. The result shows that the replacement of natural sand by recycled concrete aggregate at the level of 55% provide the highest compressive and flexural strength compared to other percentage and control specimen. However, if the replacement higher than 55%, the strength of brick was decreased for compressive and flexural strength, respectively. The relationship of compressive-flexural strength is determined from statistical analysis and the predicted result can be obtained by using equation ff,RCA = 0.5375 (fc0.3272.

  19. Two-component spin-coated Ag/CNT composite films based on a silver heterogeneous nucleation mechanism adhesion-enhanced by mechanical interlocking and chemical grafting

    Science.gov (United States)

    Zhang, Yang; Kang, Zhixin; Bessho, Takeshi

    2017-03-01

    In this paper, a new method for the synthesis of silver carbon nanotube (Ag/CNT) composite films as conductive connection units for flexible electronic devices is presented. This method is about a two-component solution process by spin coating with an after-treatment annealing process. In this method, multi-walled carbon nanotubes (MWCNTs) act as the core of silver heterogeneous nucleation, which can be observed and analyzed by a field-emission scanning electron microscope. With the effects of mechanical interlocking, chemical grafting, and annealing, the interfacial adhesive strength between films and PET sheets was enhanced to 12 N cm-1. The tensile strength of the Ag/CNT composite films was observed to increase by 38% by adding 5 g l-1 MWCNTs. In the four-probe method, the resistivity of Ag/CNT-5 declined by 78.2% compared with pristine Ag films. The anti-fatigue performance of the Ag/CNT composite films was monitored by cyclic bending deformation and the results revealed that the growth rate of electrical resistance during the deformation was obviously retarded. As for industrial application, this method provides an efficient low-cost way to prepare Ag/CNT composite films and can be further applied to other coating systems.

  20. Arthrodesis of the proximal interphalangeal joint of the 4th and 5th finger using an interlocking screw device to treat severe recurrence of Dupuytren's disease.

    Science.gov (United States)

    Novoa-Parra, C D; Montaner-Alonso, D; Pérez-Correa, J I; Morales-Rodríguez, J; Rodrigo-Pérez, J L; Morales-Suarez-Varela, M

    2017-12-04

    To assess the radiological and functional outcome of arthrodesis of the 4th and 5th finger using the APEX™ (Extremity Medical, Parsippany,NJ)intermedullary interlocking screw system in patients with severe recurrence of Dupuytren's disease. The DASH questionnaire and the VAS scale were used to assess the clinical outcomes. The angle of arthrodesis, fusion time and implant fixation were evaluated on x-rays. The patients were monitored for complications during surgery and the follow-up period. The sample comprised 6 patients. Mean follow up was 19.6 months. All of the patients presented clinical and radiological evidence of fusion at 8 weeks, with fusion angles of 30° (3) and 45° (3). There were no complications and none of the implants had to be removed. The functional outcomes in these patients were poor. The system offers a reliable method for IPJ arthrodesis at a precise angle. It promotes stable fixation that does not require prolonged immobilisation. It can be used together with other procedures on the hand with severe recurrence of DD. The functional outcomes for this group of patients using this device were poor. Copyright © 2017 SECOT. Publicado por Elsevier España, S.L.U. All rights reserved.